tbuckley/cabot-search huggingface dataset:
Abstract 134: CCN5 down regulates HER2/ neu expression in HER2 positive breast cancer cells
Authors: Sandipto Sarkar, Gargi Maity, Amlan Das, Monami Majumder, Snigdha Banerjee, Sushanta Banerjee
Journal: Cancer Research (2015)

Abstract Breast cancers are broadly classified into four different subtypes which are Luminal A, Luminal B, Basal type and Her2 positive cancers. The cells in Her2 positive tumor lesions overexpress the tyrosine kinase receptor ErbB2 or Her2 which serve as the major oncoprotein and drives the unrestrained proliferation of the cells which is one of the major hallmarks of cancer. About 25% of the breast cancer overexpress Her2 (ErbB2) proto-oncogene resulting in aggressive tumor phenotype and is associated in poor prognosis in patients. Though Her2 targeted therapies are being used hugely in clinical practice, a significant fraction of the Her2 positive tumors develop mechanisms to evade the targeted therapies of Her2 inhibition. CCN5 or Wisp2 is a matricellular protein which is now considered as an ‘anti-invasive gene’. It has been already that established from multiple evidences that CCN5 protein inhibits progression of triple negative breast cancer. The goal of the study is to investigate if CCN5 can regulate Her2 in Her2 positive breast cancer. We have found that CCN5 treatment also negatively regulates expression and activity of Her2 receptor in Her2 overexpressed breast cancer cells. It has been indicated from Her2 promoter assays that Wisp2/CCN5 negatively regulates the expression of Her2 in a transcriptional level. Wisp2 /CCN5 treatment of Her2 overexpressed breast cancer cell lines, SKBR3 and Bt474, exerts a negative impact on the migration and proliferative properties of the cancer cells. Thus it can be concluded that our initial studies on effect of CCN5 on Her2 positive cells can pave the way for a novel approach of therapy to control Her2 overexpressed tumor cell growth. Citation Format: Sandipto Sarkar, Gargi Maity, Amlan Das, Monami Majumder, Snigdha Banerjee, Sushanta Banerjee. CCN5 down regulates HER2/ neu expression in HER2 positive breast cancer cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 134. doi:10.1158/1538-7445.AM2015-134
Abstract 3863: The stemness of gastric cancer stem cells is sustained by TGFβ produced from cancer-associated fibroblasts
Authors: Masakazu Yashiro, Tsuyoshi Hasegawa, Tatsunari Fukuoka, Haruhito Kinoshita, Tamami Morisaki, Hiroaki Kasashima, Go Masuda, Naoshi Kubo, Kosei Hirakawa
Journal: Cancer Research (2014)

Abstract Purpose: Cancer-associated fibroblasts (CAFs) have recently been implicated in tumor growth and metastasis in gastric cancer. Cancer stem cells. (CSCs) have been proposed to have an important role in cancer progression. CSCs are known to display stem cell properties, “stemness”, the ability to sustain self-renewal. Because CAFs are abundant in the stroma of gastric cancer, CAFs are supposed to affect CSC characteristics of gastric cancer. However, the effects of CAFs on the characteristics of gastric cancer CSCs have not been clarified. The aim of this study was to clarify the effect of CAFs on CSCs characteristics in gastric tumor microenvironment. Experimental Design: Four gastric cancer cell lines, OCUM-12, OCUM-2MD3, MKN-45, and MKN-74, were used. Side population (SP) cells were sorted by flow cytometry as CSC-rich cells from each parent cell line. CaF-37 was established from the tumoral gastric specimens as CAFs. Flow cytometric analysis of SP fraction, spheroid colony assay, and RT-PCR analysis of CSC markers, ABCG2, ALDH1, CD44, CD133, NANOG, and OCT3/4, were performed to identify CSCs properties. Effect of CAFs on the tumorigenicity by OCUM-12/SP cells was examined using nude mice. Results: CaF-37 significantly increased the percentages of the SP fraction of scirrhous-type of gastric cancer cells, OCUM-12/SP and OCUM-2MD3/SP cells, but not that of non-scirrhous-type of gastric cancer cells, MKN-45/SP and MKN-74/SP cells. Taken together, CaF-37 significantly increased the number of spheroid colonies and the expression level of CSC markers of scirrhous-type of gastric cancer cells. These stimulating-activities by CaF-37 were significantly decreased by TGFβ inhibitors, but not FGFR and cMet inhibitor. Also, SP fractions of scirrhous-type of gastric cancer cells were significantly increased by TGFβ, but not by FGF2 and HGF. Tumorigenicity by subcutaneous co-inoculation of OCUM-12/SP cells with CaF-37 was significantly high in comparison with that by OCUM-12/SP cells alone. Phospho-Smad2 expression level was significantly increased by co-inoculation with CaF-37. Conclusions: TGFβ from CAFs in the tumor microenvironment might sustain the stemness of CSCs of gastric cancer cells, especially in scirrhous-type of gastric cancer. Citation Format: Masakazu Yashiro, Tsuyoshi Hasegawa, Tatsunari Fukuoka, Haruhito Kinoshita, Tamami Morisaki, Hiroaki Kasashima, Go Masuda, Naoshi Kubo, Kosei Hirakawa. The stemness of gastric cancer stem cells is sustained by TGFβ produced from cancer-associated fibroblasts. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3863. doi:10.1158/1538-7445.AM2014-3863
ACUTE DISSEMINATED LUPUS ERYTHEMATOSUS IN THE NEGRO MALE: REPORT OF CASE WITH AUTOPSY FINDINGS
Authors: R IRBY, G R HENNIGAR, J KIRK
Journal: Annals of Internal Medicine (1952)

Case Reports1 December 1952ACUTE DISSEMINATED LUPUS ERYTHEMATOSUS IN THE NEGRO MALE: REPORT OF CASE WITH AUTOPSY FINDINGSROBERT IRBY, G. R. HENNIGAR, JACQUELINE KIRKROBERT IRBY, G. R. HENNIGAR, JACQUELINE KIRKAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-6-1274 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptReports of the acute form of disseminated lupus erythematosus in the Negro race are few. Vessey and Nelson1reported the case of a 23 year old colored male with necropsy findings. This was the first report of the acute form of the disease in a colored male recorded in the North American literature. Kirby-Smith2recorded two cases of discoid lupus in Negro male youths. His photographs of the typical "butterfly" appearance of the facial skin lesions were classic. Pastor, Sloane and Goldburgh3reported necropsy findings in five male patients with acute disseminated lupus erythematosus, two of whom were colored males,...Bibliography1. VesseyNelson JMHG: Acute disseminated lupus erythematosus: report of the disease in a Negro male, Ann. Int. Med. 32: 565-571, 1950. LinkGoogle Scholar2. Kirby-Smith JL: Erythematosus lupus in Negro youth, J. Florida M. A. 26: 141-143, 1939. Google Scholar3. PastorSloaneGoldburgh BHNGHL: Disseminated lupus erythematosus in the male: report of five cases, New England J. Med. 244: 81-84, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Richmond, Virginia*Received for publication January 30, 1952.From the Departments of Medicine and Pathology, Medical College of Virginia, Richmond, Virginia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPericardial Effusion, a Manifestation of Systemic Lupus ErythematosusKrankheiten der GefäßeCollagen Diseases 1 December 1952Volume 37, Issue 6Page: 1274-1280KeywordsAdolescentsAutopsyLesionsLupus erythematosusRacial and ethnic issues ePublished: 1 December 2008 Issue Published: 1 December 1952 PDF downloadLoading ...
Abstract 3737: Assessment of Aortic Stenosis by Three-dimensional Echocardiography: Comparison with Standard Echocardiographic Techniques and Cardiac Catheterization
Authors: Sorel Goland, Alfredo Trento, Kiyoshi Iida, Lawrence S Czer, Kirsten Tolstrup, Michele De Robertis, Takashi Akima, Huai Luo, Robert J Siegel
Journal: Circulation (2006)
Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506
Authors: David Peters, Masahiro Tsuchida, Eric R. Manthei, Tausif Alam, Clifford S. Cho, Stuart J. Knechtle, Majed M. Hamawy
Journal: Blood (2000)
Premutation Alleles and Fragile X–Associated Tremor/Ataxia Syndrome
Authors: Mathias Toft, Matthew Farrer
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FcαRI-positive liver Kupffer cells: Reappraisal of the function of immunoglobulin A in immunity
Authors: Marjolein van Egmond, Evert van Garderen, Annemiek B. van Spriel, Cora A. Damen, Edwin S. van Amersfoort, Ger van Zandbergen, Jan van Hattum, Johan Kuiper, Jan G.J. van de Winkel
Journal: Nature Medicine (2000)
Basic Nutrition and Diet Therapy.
Authors: Sue Rodwell Williams
Journal: Annals of Internal Medicine (1991)

INTRODUCTION TO BASIC PRINCIPLES OF NUTRITIONAL SCIENCE Food, Nutrition, and Health Carbohydrates Fats Proteins Energy Balance Vitamins Minerals Water Balance Digestion and Absorption NUTRITION THROUGHOUT THE LIFE CYCLE Nutrition During Pregnancy and Lactation Nutrition in Infancy, Childhood, and Adolescence Nutrition For Adults: The Early, Middle, and Later Years COMMUNITY NUTRITION AND HEALTH CARE Community Food Supply and Health Food Habits and Cultural Patterns Weight Management Nutrition and Physical Fitness CLINICAL NUTRITION Nutritional Care Gastrointestinal Problems Coronary Heart Disease and Hypertension Diabetes Mellitus Renal Disease Surgery and Nutritional Support Nutritional Support in Cancer and AIDS
Abstract MP63: Cardiovascular Health and Cumulative Burden of Disease in a Rural Adult Population
Authors: Stephanie J Frisbee, Sheldon Steiner, Courtney Pilkerton, Sarah Singh, Adam Christian, Thomas K Bias
Journal: Circulation (2015)

BACKGROUND: Cardiovascular disease, the leading cause of death in the U.S, is associated with significant socioeconomic and geographic disparities. These disparities may create challenges with individual- or population-based strategies aimed at improving cardiovascular health, particularly if poor cardiovascular health is only one health challenge facing a community. OBJECTIVE: The objective of the current study was to assess the extent to which cardiovascular health, or the absence there of, was accompanied by one or several other health challenges, and the socioeconomic factors associated with disparities in these associations, in a cohort of rural adults. METHODS: We used the comprehensive cardiovascular health index (CVHI) developed by the American Heart Association, which incorporates behavioral and biological factors. We used data from the C8 Health Project to perform a secondary data analysis consisting of a final sample of 51,652 adults (≥20 years old) after exclusions and incomplete data. The CVH...
Abstract 16133: High Density Lipoprotein Cholesterol is an Alternative Marker to Troponin for Acute Coronary Syndrome in High Risk Patients
Authors: Anke Nguyen, Heath Adams, Natalie Yap, Julian Gin, Andrew M Wilson
Journal: Circulation (2014)

Introduction: It is well known that high density lipoprotein cholesterol is inversely correlated with the risk of coronary artery disease. However, data is limited regarding the relationship of high density lipoprotein cholesterol in the acute setting of coronary artery disease and particularly how it compares to the most well-known biomarker, cardiac troponin I. Hypothesis: We assessed the hypothesis that high density lipoprotein cholesterol could be used as an alternative marker to troponin for acute coronary syndrome (ACS) in high risk patients. Methods: We analysed 740 patients of the BRAVEHEART cohort presenting for coronary angiography at our institution between October 2009 and March 2014. Of these, 153 patients presented with ACS, including 44 with ST elevation myocardial infarction and 109 with non-ST elevation myocardial infarction, and 587 patients presented without ACS. Binary logistic regression was used to compare high density lipoprotein cholesterol and cardiac troponin I levels as predictors of ACS, independent of age, sex, cardiac risk factors and statin use. Results: Patients presenting with ACS had higher median cardiac troponin I levels (0.34 vs. 0.02 μg/L; p&lt;0.001), higher median serum triglyceride levels (1.5 vs. 1.3 mmol/L, p&lt;0.001) and lower median high density lipoprotein cholesterol levels (0.97 vs. 1.09 mmol/L, p&lt;0.001) than patients without ACS. There was no difference in total cholesterol and low density lipoprotein cholesterol between the two groups. After adjusting for differences in patient variables, the strongest independent predictors of ACS were cardiac troponin I (odds ratio (OR), 1.50; 95% confidence interval (CI), 1.24-1.82; p&lt;0.001) and high density lipoprotein cholesterol (OR, 0.12; 95% CI, 0.04-0.36; p&lt;0.001). Conclusion: In conclusion, high density lipoprotein cholesterol was found to be an independent marker of ACS in high risk patients at our institution. Further studies on high density lipoprotein cholesterol could determine its clinical use in conjunction with troponin levels in patients presenting with ACS.
Large Area of the False Lumen Favors Secondary Dilatation of the Aorta After Acute Type A Aortic Dissection
Authors: Franz F. Immer, Eva Krähenbühl, Urs Hagen, Mario Stalder, Pascal A. Berdat, Friedrich S. Eckstein, Jürg Schmidli, Thierry P. Carrel
Journal: Circulation (2005)

Background— Since 1994 patients with acute aortic dissection type A (AADA) are followed-up in our outpatient clinic. Early diagnosis of secondary dilatation of the diseased aorta is crucial to reduce late mortality in these patients. Aim of the present study is to asses the impact of a large volume in the false lumen of the diseased downstream aorta on secondary dilatation. Methods and Results— 134 patients of 264 patients who underwent surgery for AADA (between January 1994 and June 2003) are followed-up at our outpatient clinic since 1994. 84 patients (62.7%) fulfilled the inclusion criteria. Areas of the true and the false lumens of the aorta were analyzed and a logistic regression was calculated at 5 levels of the aorta for each patient. Patients were divided in 3 groups: group 1 included 34 patients (40.5%) without progression, group 2 had 34 patients (40.5%) with slight progression, and group 3 had 16 patients (19.0%) with important progression, requiring surgery in all patients. In 87.5% of the patients the area of the original lumen was &lt;0% in group 3, compared with 11.8% in group 2 and 8.8% in group 1 in relation to the total area of the aorta 6 months after surgery ( P &lt;0.001). Conclusion— A large false lumen, with an area of the true lumen &lt;30% 6 months after surgery, is the strongest predictor for secondary dilatation of the diseased downstream aorta.
The treatment of vitiligo with topical corticosteroids.
Authors: STANLEY S. BLEEHEN
Journal: British Journal of Dermatology (1976)

Twenty patients with lesions of vitiligo were treated either with 0.1% betamethasone valerate (BV) or with 0.05% clobetasol propionate (CP) creams and similar control areas with placebo preparations. After 3 months of treatment three of the ten patients treated with BV showed a significant amount of repigmentation only in the steroid-treated areas. Only one of the ten patients treated with CP showed partial repigmentation. Using both light and electron microscopy, histological studies of biopsies taken from control- and steroid-treated areas showed a marked repopulation with functional melanocytes in the repigmenting vitiliginous skin. The melanocytes in these steroid-treated repigmented areas were more dendritic and dopa-positive and, unlike melanocytes in the pigmented margins of untreated areas of vitiligo, contained many melanosomes of normal size, shape and melanization. It appears that both topical corticosteroids are of use for the treatment of selected patients with vitiligo and can induce repigmentation of the skin.
Translation gene expression profiling into the identification of high frequency of methylation markers in cervical neoplasia: novel panel of 3 genes of the CpG island methylator phenotype(CIMP) for high-grade squamous intraepithelial (HSIL) or worse.
Authors: Sungwhan An, TaeJeong Oh, SungKyong Son, Young Tae Kim, Heung Tae Noh, ChangJin Kim, YoungMi Won, JinGu Lee, YoungHo Moon, Chi-Wang Yoong, Hyun Cheol Chung
Journal: Clinical Cancer Research (2006)

A101   We have developed a systematic and stepwise genome-scale screening system to discover a new panel of genes enable to represent the high frequency of promoter methylation in the cervical cancer and its precursor lesions including carcinoma in situ (CIS) and high-grade squamous intraepithelial(HSIL). Considering that aberrant promoter methylation-mediated silencing of tumor suppressor genes has significant tissue specificity, we firstly investigated a subset of genes relatively decreased in gene expression in cervical cancer(CC) and biopsy specimens of precursor lesions (CC in 8, CIS in 2, and HSIL in 5) compared with normal-appearing biopsies in 7 using 35K microarray. We secondly analyzed expression profiles to identify genes epigenetically reactivated in four CC derived cell lines after treatment with methylation inhibiting agent, 5-aza-29-deoxycytidine. We obtained 53 genes by cross-comparison two gene lists and reduced to 28 through two additional steps,  in silico  search for whether CpG islands exist or not and following examination for methylation status of each gene by PCR after digestion with restriction-enzymes,  Hpa II and  Msp I, in 4 CC cell lines. To determine the degree of methylation frequency of 28 filtered genes in CC or its precursor cells present at exfoliated cell samples, each gene was examined with DNA of smears from patients with CC in 1, CIS in 2, HSIL in 3, LSIL in 3, and normal in 3. We selected a panel of 10 genes for further clinical validations because they showed the high frequency of methylation in HSIL or worse while very low in LSIL or less. We then evaluated the panel as a CpG islands methylator phenotype (CIMP) with 134 cytological smears diagnosed as normal in 70, atypical squamous cell of undetermined significance (ASCUS) in 5, LSIL in 26, HSIL in 11, CIS in 10 and CC in 12. The frequency of methylation was overall increased with increasing grade of histological abnormality. Five out of ten showed a statistical significance ( p
Brazilian spotted fever: two faces of a same disease? A comparative study of clinical aspects between an old and a new endemic area in Brazil
Authors: R.N. Angerami, A.M.R. da Silva, E.M.M. Nascimento, S. Colombo, M.Y. Wada, F.C.P. dos Santos, D.M. Mancini, R.C. de Oliveira, G. Katz, E.C. Martins, L.J. da Silva
Journal: Clinical Microbiology and Infection (2009)
Abstract 260: The Effect of Time to Bystander Cardiopulmonary Resuscitation on Survival From Out-of-hospital Cardiac Arrest From All-Japan Utstein Registry Data: A Validation of 3-Phase Sensitive Model
Authors: Naohiro Yonemoto, Hiroyuki Yokoyama, Ken Nagao, Takeshi Kimura, Nonogi Hiroshi
Journal: Circulation (2010)
Chimmitecan, a novel 9-substituted camptothecin, is a promising anticancer drug candidate.
Authors: Min Huang, Hong Zhu, Heyong Gao, Yi Chen, Yujun Cai, Xiongwen Zhang, Zehong Miao, Hongwu Shen, Liping Lin, Wei Lu, Jian Ding
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

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Recently, lipophilic analogs of camptothecin are found to overcome the drawbacks of water soluble ones. 7-substituted lipophilic derivatives have been confirmed to exhibit potent anti-tumor activity and improved pharmaceutical profiles. We made structural modifications of camptothecin at 9-position and synthesized a series of novel 9-substituted lipophilic analogues. Among them chimmitecan (9-allyl-10-hydroxycamptothecin), characterized by some features of both lipophilic and water soluble analogs, was selected for pre-clinical development. It showed special affinity to many conventional solvents and such favourable property made it easier for administration than other lipophilic ones. Cytotoxity of chimmitecan against 20 human tumor cell lines was more potent than that of lipophilic SN38, the active metabolite of irinotecan (CPT-11) and water-soluble topotecan (TPT). No cross-resistance to chimmitecan was found in multi-drug resistance (MDR) cells overexpressing P-glycoprotein. Moreover, the potent cytotoxity of chimmitecan was not influenced by human serum albumin (HSA). The superiority in cytotoxity of chimmitecan compared with TPT and SN38 was possibly due to its outstanding action on topoisomerase I (Topo I), including inhibiting Topo I catalytic activity, trapping Topo I-DNA covalent cleavable complex and especially, stabilizing the persistence of Topo I-DNA complex. Such strong action with specific target of camptothecins consequently led to downstream effects, inducing DNA damage and subsequently resulting in G2/M and S phase arrest and apoptosis in human leukemia HL60 cells at submicromolar levels. In vivo , chimmitecan was effective in all five human tumor xenografts nude mice models including the non-small cell lung carcinoma A549, breast carcinoma MDA-MB-435, hepatic carcinoma BEL-7402, SMMC-7721 and colon carcinoma HCT-116 models. Difference was found between sensitivity of xenografts models to CPT-11 and chimmitecan, with the latter superior to CPT-11 in A549 and BEL-7402 tumor xenografts. In addition, chimmitecan exhibited antitumor efficiency with oral administration in tumor bearing mice. Taken together, our results demonstrated chimmitecan was endowed with advantages as: (a) potent cytotoxity (b) persistence of the drug-target complex (c) anti-MDR activity (d) better solubility (e) oral administration efficiency and (f) individual tumor sensitivity compared with reference drugs. Above mentioned research results indicate chimmitecan is a promising anticancer drug candidate deserving of further development.