tbuckley/cabot-search huggingface dataset:
Dispersion and Attenuation of Small Artificial Pressure Waves in the Canine Aorta
Authors: MAX ANLIKER, MICHAEL B. HISTAND, ERIC OGDEN
Journal: Circulation Research (1968)

A method was developed to determine the elastic behavior of large blood vessels in terms of their transmission characteristics for small sinusoidal pressure signals. The method is new insofar as it utilizes transient signals of the form of finite trains of sine waves that are superimposed on the naturally occurring pressure fluctuations and are generated by an electrically driven impactor or by a pump. Its application to the thoracic aortas of 18 mature mongrel dogs anesthetized with pentobarbital has shown that dispersion and attenuation data for frequencies between 40 and 200 cps can be obtained without requiring either Fourier transform computations or resolution of reflection interference. For the frequency range considered, the descending aorta is only mildly dispersive but exhibits strong attenuation that must be attributed primarily to dissipative mechanisms in the vessel wall. At normal blood pressure levels, the wave speed during diastole can have a value between 4 and 6 m/sec. For all frequencies tested the amplitude ratio of the waves exhibits the same exponential decay pattern with distance measured in wavelengths. A marked increase in wave speed observed from diastole to systole can be associated with an increase in mean flow and with a stiffening of the aortic wall due to the rise in pressure. This phenomenon implies that the aortas of anesthetized dogs should exhibit nonlinear properties with respect to large amplitude pulse waves such as those generated by the heart.
Stress Echocardiography to Assess Stenosis Severity and Predict Outcome in Patients With Paradoxical Low-Flow, Low-Gradient Aortic Stenosis and Preserved LVEF
Authors: Marie-Annick Clavel, Pierre Vladimir Ennezat, Sylvestre Maréchaux, Jean G. Dumesnil, Romain Capoulade, Zeineb Hachicha, Patrick Mathieu, Annaïk Bellouin, Sébastien Bergeron, Patrick Meimoun, Marie Arsenault, Thierry Le Tourneau, Agnès Pasquet, Christian Couture, Philippe Pibarot
Journal: JACC. Cardiovascular imaging (2013)
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1
Authors: Marjolijn J L Ligtenberg, Roland P Kuiper, Tsun Leung Chan, Monique Goossens, Konnie M Hebeda, Marsha Voorendt, Tracy Y H Lee, Danielle Bodmer, Eveline Hoenselaar, Sandra J B Hendriks-Cornelissen, Wai Yin Tsui, Chi Kwan Kong, Han G Brunner, Ad Geurts van Kessel, Siu Tsan Yuen, J Han J M van Krieken, Suet Yi Leung, Nicoline Hoogerbrugge
Journal: Nature Genetics (2008)
Endoscopic diagnosis and treatment of gastric tumors
Authors: L. Aabakken
Journal: Endoscopy (2007)

The role of endoscopy in the handling of benign and malignant gastrointestinal tumors continues to expand, due to a combination of increasing sophistication of the equipment and ingenious improvements in the methods used. Traditional white-light surface imaging is increasingly being supplemented by other modalities, and the removal of lesions now carries a strong resemblance to minimally invasive surgery. Summarizing the abstracts from this year’s Digestive Disease Week on the endoscopic handling of gastrointestinal tumors is a vast task because this now comprises the bulk of endoscopic activity. The following summary will concentrate on methods and results related to the handling of gastric lesions.
The Cabalist: Carpy Regurgitations Concerning the Antepenultimate-Reply
Authors: Michael A. LaCombe
Journal: JAMA (1988)

In Reply.—  I sent  Anders' letter to Larry Tripe (the cabalist), who offered this reply:  Dr Anders is right on in every way. I wish I'd had more teachers with his interest in physical diagnosis. I didn't mean to imply that Quincke's pulse was pathognomonic for aortic regurgitation—only just a red flag, as the old-timers used to say. And I do think there might be more to Bozzolo's sign. I once spent five wonderful minutes at the bed-side with an ancient, elfin, white-haired doctor with a Fuller-brush mustache. The patient, who had syphilitic aortitis, addressed him as  White with a sort of reverence and teased him about riding his bike everywhere. Anyway, the doctor had me lean close to the patient and listen at the nostrils. 'Hear that whiff-whiff sound?' he said. 'That's air moving in and out of his sinuses because of the pulsating vessels in there.
Abstract 1055: Syntenin positively regulates TGF-β1- and oncogenic Ras-mediated EMT-like phenotypic changes in cancer cells
Authors: Okhwa Kim, Cheol Hwangbo, Nara Tae, Suhyun Lee, Jeong-Hyung Lee
Journal: Cancer Research (2014)

Abstract Epithelial to mesenchymal transition (EMT) is biological process in polarized epithelial cells, which occurs in various physiological and pathological conditions. In carcinoma progression, EMT has emerged as a critical player in regulating cancer cell invasive phenotype. Syntenin, a tandem PDZ-domain containing scaffold protein, functions as a positive regulator of cancer cell progression in several human cancers. In present study, we investigated a role of syntenin in transforming growth factor (TGF)-β1- and Ras-V12-mediated EMT-like phenotypic changes in cancer cells. Knockdown of syntenin suppressed TGF-β1- and Ras-V12-induced morphological and cell biological alterations in A549, Ep/Ras, and BEAS-2B cells that are consistent with EMT; however, overexpression of syntenin stimulated TGF-β1- and Ras-V12-induced EMT, implying that syntenin is necessary for TGF-β1- and Ras-V12- induced EMT. We found that syntenin is associated with RSK (p90 ribosomal S6 kinase) via PDZ binding motif and syntenin at Ser6 residue may directly be phosphorylated by RSK. Mutation of syntenin Ser6 to Ala suppresses TGF-β1- and oncogenic Ras-mediated EMT in a dominant negative manner by abolishing the interaction of endogenous syntenin with RSK. Strikingly, expression of syntenin-S6E, a phosphomimetic mutant of syntenin at Ser6, into A549, Ep/Ras, or BEAS-2B cells induced EMT-like phenotypic changes, characterized by down-regulation of E-cadherin and up-regulation of vimentin, Snail and Slug, suggesting that Ser6 phosphorylation of syntenin by RSK is necessary and sufficient for the induction of EMT mediated by TGF-β1. In addition, we sought to determine whether Ser6 phosphorylation of syntenin would modulate in vivo metastasis in a mouse model. A549 cells expressing syntenin-S6E dramatically increased lung metastases. Based on these data, we conclude that phosphorylation of syntenin at Ser6 by RSK is necessary and sufficient for the induction of EMT and metastasis in certain cancer cells. Citation Format: Okhwa Kim, Cheol Hwangbo, Nara Tae, Suhyun Lee, Jeong-Hyung Lee. Syntenin positively regulates TGF-β1- and oncogenic Ras-mediated EMT-like phenotypic changes in cancer cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1055. doi:10.1158/1538-7445.AM2014-1055
Tc-99m DISIDA Scan Findings in Two Large Choledochal Cysts in the Same Patient
Authors: Kyung-Hoon Hwang, Chan H. Park, Ok Hwa Kim, Jeong Hong
Journal: Clinical Nuclear Medicine (2001)

Hwang, Kyung-Hoon M.D.*; Park, Chan H. M.D.*; Hwa Kim, Ok M.D.†; Hong, Jeong M.D.‡ Author Information
Morphometric Analysis of Bronchial Cartilage in Chronic Obstructive Pulmonary Disease and Bronchial Asthma
Authors: MASAHIKO HARAGUCHI, SANAE SHIMURA, KUNIO SHIRATO
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

To clarify the changes in bronchial cartilage in diseased airways, we performed morphometric analysis of airways in autopsied lungs of 16 patients with chronic bronchitis (Group CB), pulmonary emphysema (Group PE), and bronchial asthma (Group BA), and in control patients without respiratory diseases (Group CN). Although degeneration of bronchial cartilage was clearly observed in airways from all groups except Group CN, the most extreme change was seen in Group CB. Increased perichondrial fibrosis was observed in both Groups CB and BA, and the more extreme change was seen in Group BA. Both the area proportions of degenerated cartilage (Deg%) and perichondrial fibrosis (Fib%) to total cartilage in bronchi (3 to 8 mm in diameter), cut vertically in the cross-section profile, were measured with a digitizing tablet coupled to a computer. No significant differences in the area proportion of cartilage to bronchial wall were observed among the four study groups. The Deg% values of Groups CB (mean: 15.4%), BA (mean: 12.9%), and PE (mean: 9.6%) were significantly higher than those of Group CN (mean: 1.0%) (p < 0.01 in each case). The Deg% values correlated significantly with the number of neutrophils in the bronchial walls (r = 0.63, p < 0. 01). Both Group CB (mean: 28.5%) and Group BA (mean: 33.6%) showed significantly higher values of Fib% than did Group CN (mean: 18.5%) (p < 0.01, each), and the value for Group PE (mean: 21.8%) was slightly increased (p < 0.05). The values of Fib% correlated significantly with the number of eosinophils in the bronchial walls (r = 0.51, p < 0.05), thickness of basement membrane (r = 0.77, p < 0.0002), bronchial gland area (r = 0.56, p < 0.02), and goblet-cell area (r = 0.55, p < 0.02). Further, the values of Deg% correlated significantly with those of Fib% (r = 0.64, p < 0.01). These findings indicate that airways in chronic obstructive pulmonary disease and bronchial asthma have both degenerative changes in the cartilage (chondrocytes) and increased perichondrial fibrosis, and that these alterations in bronchial cartilage may differ in chronic bronchitis and bronchial asthma.
A Comprehensive Primer on Medical Genetics
Authors: Reed E. Pyeritz
Journal: Annals of Internal Medicine (1999)

Medical Writings: Book Notes21 December 1999A Comprehensive Primer on Medical GeneticsReed E. Pyeritz, MD, PhD, MCPReed E. Pyeritz, MD, PhD, MCPHahnemann School of Medicine, Pittsburgh, Pennsylvania. (Pyeritz)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-12-199912210-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Thurmon TF. 483 pages. New York: Parthenon; 1999. $39.95. ISBN 1850700664. Order phone 800-735-4744.Field of medicine: Human and medical genetics.Format: Softcover book.Audience: Medical students, postgraduate trainees, and others interested in learning about medical genetics.Purpose: To provide a problem-based self-instruction text for health professionals who have not had a course in genetics and for patients with hereditary disorders.Content: Twenty chapters cover most aspects of human and medical genetics. Three appendices provide graphs of normal laboratory values, directions for record keeping, and guides to signs of syndromes that involve multiple congenital anomalies.Highlights: The attempt to create ... Author, Article, and Disclosure InformationAffiliations: Hahnemann School of Medicine, Pittsburgh, Pennsylvania. (Pyeritz) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 December 1999Volume 131, Issue 12Page: 981KeywordsCongenital disordersEnzymesGenetic diseasesHuman geneticsMedical geneticsResearch laboratoriesSoftware tools Issue Published: 21 December 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
CHANGES IN VAGINAL EPITHELIUM DURING PREGNANCY IN RELATION TO THE VAGINAL CYCLE
Authors: M. EDWARD DAVIS
Journal: JAMA (1935)

Since the investigations of Hitschmann and Adler<sup>1</sup>on the cyclic changes in the uterine mucosa, other portions of the mullerian tract have been studied in an attempt to show similar physiologic activity. Novak and Everett have demonstrated in the human female that there are secretory cells in the epithelium of the fallopian tubes which undergo cyclic secretory changes. Seckinger and Snyder<sup>2</sup>noted that the spontaneous contractions of the fallopian tube became more marked and rapid in the mid and late intervals following ovulation. This activity was greatly diminished during pregnancy. Dierks<sup>3</sup>in 1927 published the results of his study of the human vaginal cycle. He obtained pieces of vaginal mucosa from about thirty women from whom he was able to obtain accurate menstrual histories. In his description of the vaginal epithelium he states that it is composed of three layers—a basal layer, a functional layer and a
Handcrafted two-channel colonoscope for removing large lipomas
Authors: M. Matsushita, N. Danbara, M. Shimatani, T. Matsumoto, K. Uchida, M. Omiya, K. Okazaki
Journal: Endoscopy (2007)

We read with interest the article by Koo & Kaffes [1] on a novel endoscopic technique for removing large colonic lipomas in which an endoloop was used to reduce the potential risk of bleeding. The device allowed successful endoscopic removal of four lipomas in three symptomatic patients, resulting in resolution of their symptoms without major complications. They used a two-channel endoscope, and placed an endoloop around the tumor base with the assistance of a grasping forceps. The technique had already been reported for the endoscopic removal of large pedunculated polyps [2] and large lipomas [3]. The main drawback of this technique, however, is that two-channel endoscopes are not available in every hospital [4].
Laser-induced Shockwave Lithotripsy of Gallstones
Authors: Ch. Ell, F. Wondrazek, F. Frank, J. Hochberger, G. Lux, L. Demling
Journal: Endoscopy (1986)

With the aid of a Q-switched Nd:YAG laser with energy transmission via a flexible glass fiber, it proves possible under laboratory conditions, to destroy gallstones reliably and reproducibly. Lithotripsy is effected mechanically via a laser-induced local shockwave.
Abstract 3438: Expression of a novel tumor-derived axonal guidance molecule Sema7a in a breast cancer model
Authors: Ramon Garcia-Areas, Stephania Libreros, Vijaya L. Iragavarapu-Charyulu
Journal: Cancer Research (2010)

Abstract The purpose of this study is to explore the expression of axonal guidance molecule Sema7a by breast cancer cells and the possible hijacking of macrophages by Sema7a to promote tumor growth. We have recently identified the novel expression and secretion of axonal guidance molecule Sema7a by two different mouse mammary tumor cells both in vitro and in vivo. No studies have yet elucidated the implications of Sema7a expression in cancer. The over-expression of Sema7a in murine breast cancer cell lines may parallel the expression of this axonal guidance molecule in human breast cancer. Furthermore, we have evidence that Sema7a is expressed at higher levels in the macrophages and activated T lymphocytes of tumor bearers compared to the normal mice. To determine the role of the tumor on Sema7a expression, Sema7a expression was assessed in macrophages and T cells from normal mice cultured with tumor-derived factors. Sema7a, originally discovered for its chemotactic activity, is a known immune modulator through α1β1integrins. Sema7a mediates chemotaxis of human peripheral blood monocytes and induces them to produce proinflammatory cytokines, including IL-1β, IL-6, TNF-α, and IL-8. Murine macrophages treated with Sema7a significantly increased their expression of CXCL2/MIP-2 an angiogenic chemokine that is a homologue of human IL-8. This proinflammatory chemokine is known to promote leukocyte-mediated angiogenesis and tumor growth. Monocytes recruited to the tumor adopt a macrophage phenotype that is of M2. M2 macrophages secrete angiogenic factors including VEGF, IL-8, and TNF-α, as well as TNF-α-dependent MMP-9 that degrades extracellular matrix to promote metastasis. It is not clear which tumor-derived factors drive the switch to M2 phenotype in the macrophages and their subsequent production of angiogenic chemokines and matrix metalloproteinases. A putative relationship between tumor-derived Sema7a and monocytes could prove valuable in establishing new research avenues towards unraveling important tumor-host immune interactions in breast cancer patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3438.
Autoimmune Complement-fixation Reaction in 1,014 Patients
Authors: E. Hackett, M. Beech, I. J. Forbes
Journal: BMJ (1960)

Gajdusek (1957, 1958), and Mackay and Gajdusek (1958) reported that fixation of complement occurred when sera from certain hospital patients were incubated with simple saline extracts of various human organs.They called this the " autoimmune complement-fixation reaction" (A.I.C.F.).It had no strict organ specificity, and it occurred most often in cases of liver disease, diffuse " collagen " disease, and macroglobulinaemia.Gajdusek (1958) gave his reasons for regarding the reaction as one between antibody and antigen, and for adopting the view that it is an "autoimmune" phenomenon.We have looked for this A.I.C.F.reaction in the sera of 1,014 medical patients in the Royal Adelaide Hospital, and report the results, together with a discussion of some possible interpretations of the reaction other than on a basis of autoimmunity. Materials and Methods Source of SeraBlood was taken as a routine from patients admitted to the beds of the professorial unit of the Royal Adelaide Hospital.Other sera were obtained from time to time from large groups of patients in other medical clinics of the hospital.A few specimens were taken selectively from cases of syphilis, yaws, cirrhosis, diffuse " collagen " disease, or from cases known to have abnormal serum protein electrophoretic patterns.Usually only one test was made on each patient, and this was soon after admission or in an acute phase of the disease, when diagnosis or management was under active consideration.Every one of the 1,014 cases was later reviewed and a diagnosis assigned without reference to the A.I.C.F.results, which were recorded separately. Complement-fixation TestComplemenit.Pooled guinea-pig serum was stored in small amounts at -20°C.Antigens.-Freshorgans, obtained surgically or at necropsy, were homogenized to a 10%,' suspension in physiological saline in a Waring blender, then centri- fuged three times at 3,000 r.p.m. for 10 minutes at +4°C. and the sediments discarded.The supernatant solution was the antigen, and was stored in small con- tainers at -20°C.for up to three months.Antigens were prepared from normal liver, kidney, lung, adrenal, and thyroid gland.Diliuenit.Calciummagnesium saline was used throughout the test (Mayer et al., 1946).
The Huntington's disease candidate region exhibits many different haplotypes
Authors: Marcy E. MacDonald, Andrea Novelletto, Carol Lin, Dan Tagle, Glenn Barnes, Gillian Bates, Sherry Taylor, Bernice Allitto, Michael Altherr, Richard Myers, Hans Lehrach, Francis S. Collins, John J. Wasmuth, Marina Frontali, James F. Gusella
Journal: Nature Genetics (1992)
Dr. Grady's Cartoon
Authors: G. H. Friedell
Journal: JAMA (1965)

The cartoon which appeared as Figure 4 in "Microscopic Diagnosis" (Current Cancer Concepts) on page 116 of the July 19, 1965, issue ofThe Journal(Vol 193) was the creation of Dr. Hugh G. Grady, Professor of Pathology at the New Jersey College of Medicine. It was first published in the<i>American Journal of Obstetrics and Gynecology</i>after its use by Dr. Arthur T. Hertig during a debate with Dr. John L. McKelvey at the 75th Annual Meeting of the American Gynecological Society in 1962. Regrettably, the legend for Figure 4 in the article did not convey this information. I should therefore like to apologize to Dr. Grady for failing to identify the cartoon as his creation.
Improving the Outcomes of Coronary Artery Bypass Surgery in New York State
Authors: Edward L. Hannan
Journal: JAMA (1994)

To assess changes in outcomes of coronary artery bypass graft (CABG) surgery in New York since 1989, when the State Department of Health began collecting, analyzing, and disseminating information regarding risk factors, mortality, and complications of CABG surgery. These new data stimulated specific quality improvement activities at hospitals throughout the state.A clinical database was used to identify significant independent risk factors and to assess risk-adjusted provider mortality rates.All 30 hospitals performing CABG surgery in New York during the period 1989 through 1992.All 57,187 patients undergoing isolated CABG surgery who were discharged from New York State hospitals in 1989 through 1992.Actual, expected (from a logistic regression model), and risk-adjusted in-hospital mortality.Actual mortality decreased from 3.52% in 1989 to 2.78% in 1992. Because average patient severity of illness increased, risk-adjusted mortality decreased even more--a decrease of 41% from 4.17% in 1989 to 2.45% in 1992. The risk-adjustment model performed well; there were no clinically or statistically significant differences between actual and predicted numbers of deaths at any of 10 levels of patient severity.We believe that this quality improvement program, based on the collection and dissemination of risk-adjusted mortality data for CABG surgery, played a significant role in the observed decline in the death rate from this procedure. Quality improvement programs based on similar principles for other procedures and conditions should be undertaken.
859. Enhancing Neurotropism with Multiple Mutations in the AAV-2 Capsid
Authors: Jianfeng Xu, Caroline Bass, Chunyan Ma, Ernest F. Terwilliger
Journal: Molecular Therapy (2005)

There is keen interest in developing practical strategies for targeting gene delivery to specific neuron populations. Unfortunately, the distinctive features of neurons, and their complex interconnections, impose stringent requirements on any potential gene delivery system. For a number of reasons, recombinant gene vectors derived from Adeno Associated Virus offer a strong set of starting candidates for this type of application. Unfortunately, standard vectors derived from AAV-2 do not disperse well after injection in the brain or spinal cord and are limited in their capacity for retrograde transport.
The effect of indomethacin on anthralin inflammation
Authors: B. RAMSAY, N. RICE, C. LAWRENCE
Journal: British Journal of Dermatology (1992)

The effect of prostaglandin inhibition, using topical indomethacin, on anthralin inflammation was studied. Indomethacin gel and gel base were applied to opposite flexor forearm skin sites of 11 volunteers for 2 h and then washed off. Anthralin and UVB were then applied to the gel‐treated skin and the anthralin‐ and UVB‐induced erythema and oedema were measured at 2, 6, 24 and 48 h using Harpenden callipers and a reflectance erythrometer. Prostaglandin inhibition was demonstrated by a significant reduction of UVB erythema at the indomethacin‐treated sites compared to the gel‐base‐treated sites. There was a small but significant reduction in anthralin erythema, but not oedema, at the indomethacin‐treated sites compared to the gel‐base sites. This study demonstrates that prostaglandins, and other inflammatory mediators because the inhibitory effect was small, are involved in anthralin inflammation.
Mechanical aids to ventilation for use in the field.
Authors: R Greenbaum
Journal: BMJ (1979)

In February 1978 the patient went skiing with his school colleagues, and being afraid of taking drugs in the presence of his friends he stopped taking his immunosuppressive therapy for two weeks.Seen again at the end of March 1978 he was azotaemic, with a plasma creatinine of 884 ,umol/l (10-0 mg/100 ml).An open biopsy of the transplant showed the signs of an acute interstitial graft rejection.Under high-dose steroids administered in addition to his continuous immunosuppressive regimen the graft function improved again, and since June 1978 the plasma creatinine is stable at about 256 tmol/l (2 9 mg/100 ml).