tbuckley/cabot-search huggingface dataset:
Libido disorders in patients with obstructive sleep apnea
Authors: Bogna Kozlowska, Karolina Wydrych, Paulina Wydrych, Lukasz Minarowski, Sylwia Chwiesko-Minarowska, Anna Kuryliszyn-Moskal, Elzbieta Chyczewska
Journal: European Respiratory Journal (2014)

Introduction:  Obstructive Sleep Apnea (OSA) is characterized by a repeated episodes of complete or partial obstruction of the upper airways during sleep, which make the affected wake up. Very often, OSA patients report decreased libido.   Aim of the study:  The assessment of the prevalence of weakened sex drive and correlation with specific OSA symptoms associated with loss of libido in studied patients.   Materials and methods:  The survey was conducted among 401 people 335 males (aged 49,5±11,7 yrs) and 65 females (aged 55,4±10,92 yrs), who were to undergo a scheduled PSG. The survey included STOP-BANG questionnaire, ESS, the quality and length of sleep, sleep breathing disorders and the presence of sexual drive impairment. PSG examination of 298 subjects (65 F, 298 M).   Results:  Mean BMI of the studied group was 31,24 kg/m 2  (min. 20,0 max. 59,1). Mean daytime sleepiness was 11,6±5,22 pts in Epworth scale. 296 subjects (40F, 256M) responded to the question regarding the disturbance of libido in relation to sleep disordered breathing. Weakened sex drive was reported by 178 patients (44,4%): 145 men (56,6%) and 33 women (82,5%), this differences were significant in U-Mann-Whitney test. Age of patients affected negatively the sex drive in men (r=0,4, pl0,05), but not in women (r=0,2, pg0,05). There was a positive correlation between AHI and BMI, ESS, age but not with weakened sex drive.   Conclusions:  Obstructive sleep apnea negatively influence the sex drive in both men and women. More women were affected by the negative influence of sleep apnea on sex drive, moreover the age of studied women did not influence the lowered libido.
Pilot study of natural human interleukin-2 in patients with chronic hepatitis B
Authors: Herbert Tilg, Wolfgang Vogel, Jeanie Tratkiewicz, Walter Ernst Aulitzky, Manfred Herold, Michael Gruber, Dietmar Geissler, Florian Umlauft, Gert Judmaier, Ulrich Schwulera, Alexander Thrun, Christian Huber
Journal: Journal of Hepatology (1993)
Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis
Authors: Kim M. O’Sullivan, Camden Y. Lo, Shaun A. Summers, Kirstin D. Elgass, Paul J. McMillan, Anthony Longano, Sharon L. Ford, Poh-Yi Gan, Peter G. Kerr, A. Richard Kitching, Stephen R. Holdsworth
Journal: Kidney International (2015)

Myeloperoxidase (MPO) is an important neutrophil lysosomal enzyme, a major autoantigen, and a potential mediator of tissue injury in MPO-ANCA-associated vasculitis (MPO-AAV) and glomerulonephritis. Here we examined MPO deposition in kidney biopsies from 47 patients with MPO-AAV. Leukocyte accumulation and fibrin deposition consistent with cell-mediated immunity was a major feature. Tubulointerstitial macrophage, CD4+ and CD8+ T-cell, and neutrophil numbers correlated with low presenting eGFR. MPO was not detected in kidneys from patients with minimal change or thin basement membrane disease, but was prominent in glomerular, periglomerular, and tubulointerstitial regions in MPO-AAV. Extracellular MPO released from leukocytes was pronounced in all MPO-AAV patients. Similar numbers of neutrophils and macrophages expressed MPO in the kidneys, but colocalization studies identified neutrophils as the major source of extracellular MPO. Extraleukocyte MPO was prominent in neutrophil extracellular traps in the majority of patients; most of which had traps in half or more glomeruli. These traps were associated with more neutrophils and more MPO within glomeruli. Glomerular MPO-containing macrophages generated extracellular trap-like structures. MPO also localized to endothelial cells and podocytes. The presence of the most active glomerular lesions (both segmental necrosis and cellular crescents) correlated with intraglomerular CD4+ cells and MPO+ macrophages. Thus, cellular and extracellular MPO may cause glomerular and interstitial injury.
Abstract 16335: Importance of Chest Compression Release and Its Interaction With Depth for Improving Blood Flows and Pressures During CPR
Authors: Joshua W Lampe, Tai Yin, George Bratinov, Theodore Weiland, Christopher L Kaufman, Lance B Becker
Journal: Circulation (2014)

Introduction: During cardiac arrest, chest compression (CC) release has been associated with improved survival. A detailed investigation of the effect of CC release on hemodynamics and its interaction with CC depth has not been performed. Methods: CPR was studied in 17 domestic swine (~30 Kg) using standard physiological monitoring. Flow was measured in the abdominal aorta, the inferior vena cava (IVC), the right renal artery and vein, the right common carotid artery and external jugular vein. Ventricular fibrillation (VF) was electrically induced. Mechanical CC were started after ten minutes of untreated VF. CC waveforms varied so that sternal release occurred over 100 ms, 200 ms, or 300 ms. CC were delivered at a rate of 100 per minute and at a depth of 1.25”(n=9) or at a depth of 1.9” (n=8) for a total of 18 minutes. Transitions between waveforms occurred every 2 min and were randomized. Results: Aortic and coronary perfusion pressures (CPP) were highest with a 200 ms release and CPP was highest at 1.9...
Care of the Chronic Sick
Authors: T. McKeown, C. R. Lowe
Journal: BMJ (1950)

The transfer of responsibility for the care of the chronic sick in hospital from Local Authorities to Regional Hospital Boards has raised two important questions. First, Regional Hospital Boards have to decide on the location and number of beds to be provided for this class of patient. Their waiting lists indicate that more accommodation is needed, but more accommodation of the existing type would aggravate staffing difficulties which are already serious. The alternative possibility of catering for these patients in general hospitals has much to recommend it, but raises the objection that the apparent number of patients would prohibit the general application of such a policy. Second, Local Authorities have to agree on the interpretation of those sections of Part III of the National Health Services Act* (1946) and of Part III of the National Assistance Actf (1948), which refer to their responsibility for complementary facilities. The intention of the acts is evidently to leave to Local Authorities domiciliary and institutional care of persons who need not be admitted to hospitals, but the wording of the acts reflects the lack of informa tion about the numbers and types of patients for whom Local Authorities will be expected to cater. The fact that social as well as medical needs have in the past determined the admission and retention of patients in hospitals for the chronic sick suggested that the number of patients now in hospital is unreliable as a guide to future develop ments. Consideration of the medical, nursing, and social requirements of 1,005 patients in one hospital indicated that about three-fifths were not in need of hospital services and could have been cared for in their own homes or in institutions other than hospitals (Lowe and McKeown, 1949). One-fifth of the patients required institutional supervision because of their abnormal mental state, and only the remaining one-fifth were in need of services which could properly be considered the concern of general hospital authorities. Reduced to these dimensions, the problem of the chronic sick in hospital can be reconsidered in relation to the general hospitals. In this paper we examine other data which have a bearing on the commitments of Regional Hospital Boards and Local Authorities.
Biomolecular regulation of the IgE immune response
Authors: L. K. Poulsen, L. Baron, J.H. Heinig, P. Stahl Skov, K. Bendtzen
Journal: Allergy (1992)

Several cell types, including mast cells, basophils, macrophages/monocytes, lymphocytes, platelets and eosinophils, may bind or contain IgE. To investigate the source of cell‐associated IgE and its relation to spontaneous IgE synthesis, peripheral blood mononuclear cells from allergic and non‐allergic donors were examined. Using a combination of different cell fractionation techniques and varying methods for extraction of cell‐associated IgE, data were obtained indicating that monocytes constitute a major source of cell‐associated IgE in human blood. The amount of cell‐associated IgE in peripheral blood mononuclear cells from allergic and non‐allergic donors varied more than 100‐fold but correlated closely to the level of serum IgE (r = 0.84, p &lt; 0.001, n = 38). Spontaneous and mitogen‐induced in vitro syntheses of IgA, IgE and IgG were compared for allergic and non‐allergic donors. Only one donor with very high serum IgE demonstrated spontaneous or mitogen‐induced in vitro IgE synthesis despite synthesis of IgA and IgG.
Osteopontin and periostin in bronchial tissue associate with a 20-year decline of pulmonary function in asthmatics
Authors: Yoshihiro Kanemitsu, Isao Ito, Akio Niimi, Kenji Izuhara, Shoichiro Ohta, Junya Ono, Toshiyuki Iwata, Tsuyoshi Oguma, Tomoko Tajiri, Tadao Nagasaki, Yumi Izuhara, Hisako Matsumoto, Michiaki Mishima
Journal: European Respiratory Journal (2014)

Rationale:  Osteopontin and periostin are independently increased in asthmatic airways in response to Th2-driven inflammation and contribute to subepithelial fibrosis.   Objectives:  To determine whether the expression levels of osteopontin, periostin, or other factors are involved in the decline of long-standing pulmonary function by examining their expression in bronchial biopsy specimens collected at the time of initial evaluation in patients with asthma.   Methods:  Twenty asthmatics who underwent bronchoscopy between 1990 and 1995 participated in this study. Final evaluation follow-up was done in 2012. Using biopsy samples, immunohistochemistry including osteopontin-expressing cells and deposition of periostin were evaluated. Associations of annual change in forced expiratory volume in one second (ΔFEV 1 ) with histological or clinical indices were analyzed.   Measurements and Results:  Median follow-up period was 20.3 (SD 1.3) years after bronchial biopsy, and the average ΔFEV 1  was -19.1 (SD 30.8) mL/year. The numbers of osteopontin-positive cells (p = 0.004), CD8 T-lymphocytes (p = 0.01), and eosinophils (p = 0.04), and the amount of periostin deposition (p = 0.001) in bronchial subepithelium were associated with ΔFEV 1 . Multivariate stepwise analysis revealed that both osteopontin (p = 0.04) and periostin (p = 0.0497) independently affected ΔFEV 1 . Expression levels of osteopontin and periostin were related to the number of eosinophils (p = 0.04 and p = 0.047) and the expression of α smooth muscle actin (p = 0.01 and p = 0.0002).   Conclusion:  Increased expression levels of these proteins in asthmatic airways was related to an accelerated decline in FEV 1  over a long-term period.
PENICILLIN IN THE TREATMENT OF NEUROSYPHILIS. IV. CEREBROSPINAL FLUID CHANGES IN CASES OF SYMPTOMATIC NEUROSYPHILIS
Authors: F W REYNOLDS
Journal: Annals of Internal Medicine (1947)

Article1 March 1947PENICILLIN IN THE TREATMENT OF NEUROSYPHILIS. IV. CEREBROSPINAL FLUID CHANGES IN CASES OF SYMPTOMATIC NEUROSYPHILISFRANK W. REYNOLDS, M.D.FRANK W. REYNOLDS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-3-393 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA study of the effect of penicillin in various forms of neurosyphilis was begun at the Johns Hopkins Hospital in October 1943. The results of the first two years' experience are being reported in a series of papers. The first of these1 dealt with the treatment of asymptomatic neurosyphilis, the second2 with general paresis, and the third3 with Erb's spastic paraplegia. The present paper, the fourth of the series, is concerned with the changes in the cerebrospinal fluid abnormalities in various types of symptomatic neurosyphilis considered as an admittedly conglomerate whole.Although there are disadvantages in grouping together such widely...Bibliography1. MOHRMOORE CFJE: Penicillin in the treatment of neurosyphilis. I. Asymptomatic neurosyphilis, Am. Jr. Syph., Gonor. and Ven. Dis., 1946, xxx, 405. Google Scholar2. REYNOLDSMOHRMOORE FWCFJE: Penicillin in the treatment of neurosyphilis. II. Dementia paralytica, Jr. Am. Med. Assoc., 1946, cxxxi, 1255. CrossrefGoogle Scholar3. TUCKER HA: Penicillin treatment of Erb's syphilitic spinal spastic paraplegia, Bull. Johns Hopkins Hosp., 1946, lxxviii, 161. Google Scholar4. DATTNERTHOMASWEXLER BEWG: The management of neurosyphilis, 1944, Grune & Stratton, New York. CrossrefGoogle Scholar5. MOORE JE: The modern treatment of syphilis, ed. 2, 1943, Charles C. Thomas, Springfield, Ill., p. 346. Google Scholar6. : The changing character of commercial penicillin with suggestions as to the use of penicillin in syphilis, Jr. Am. Med. Assoc., 1946, cxxxi, 271. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Baltimore, Maryland*Received for publication August 1, 1946.From the United States Public Health Service and The Johns Hopkins University Venereal Disease Research and Post-Graduate Training Center, Baltimore, Md.This study was made under a contract recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and The Johns Hopkins University. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Lues des NervensystemsResultados terapêuticos em 50 casos de neurossífilisSyphilisNeurology 1 March 1947Volume 26, Issue 3Page: 393-404KeywordsCerebrospinal fluidHealth services researchMedical servicesParaplegiaPenicillinSexually transmitted diseases Issue Published: 1 March 1947 PDF downloadLoading ...
DIABETES REFRACTORY TO INSULIN, WITH REPORT OF A CASE
Authors: Samuel S. Altshuler, S. E. Gould
Journal: Annals of Internal Medicine (1936)

Case Reports1 May 1936DIABETES REFRACTORY TO INSULIN, WITH REPORT OF A CASESAMUEL S. ALTSHULER, M.D., F.A.C.P., S. E. GOULD, M.D.SAMUEL S. ALTSHULER, M.D., F.A.C.P.Search for more papers by this author, S. E. GOULD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-11-1595 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn reviewing the literature on this subject one is struck by the fact that many cases are spoken of as "insulin refractory" which might better be termed "insulin resistant," that is, cases in which an unusually large amount of insulin must be administered in order to control the glycosuria. The case which we are reporting is truly insulin refractory; no relationship is demonstrable between the amounts of insulin given and the subsequent glycosuria.In most instances the physiological responses to insulin are predictable, but the mechanism of its action is still problematical. The proper understanding of this mechanism is reserved...Bibliography1. VON MERINGMINKOWSKI : Arch. f. exper. Path. u. Pharmakol., 1889, xxvi, 371. Google Scholar2. BANTINGBEST FGCH: Internal secretion of pancreas, Jr. Lab. and Clin. Med., 1922, vii, 251-266. Google Scholar3. HOUSSAYLEWIS ABJT: Suprarenals and pancreatic diabetes, Rev. Asoc. méd. argent., 1921, xxxiv, 1099-1103. Google Scholar4. COLWELL AR: Relation of hypophysis to diabetes mellitus, Medicine, 1927, vi, 1-39. CrossrefGoogle Scholar5. COLLIP JB: Diabetogenic, thyrotropic, adrenetropic and parathyrotropic factors of the pituitary, Jr. Am. Med. Assoc., 1935, civ, 827. CrossrefGoogle Scholar6. POLLACK H: Insulin resistance, Proc. Staff. Meet. Mayo Clinic, 1933, viii, 453. Google Scholar7. MAHLERPASTERNY PK: Klinische Beobachtungen über Insulin Wirkung beim Diabetes mellitus, Med. Klin., 1924, xx, 337. Google Scholar8. ULRICH H: Antagonism between insulin and pituitary extract, Arch. Int. Med., 1928, xli, 855. Google Scholar9. CHARLTON FH: Diabetes refractory to insulin relieved by antiluetic treatment, Endocrinology, 1924, viii, 235. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Eloise, Michigan*Received for publication August 26, 1935.From the Departments of Medicine and Pathology of the William J. Seymour Hospital, Eloise, Michigan, and the Department of Pathology of Wayne University, College of Medicine, Detroit. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPituitary apoplexy: its incidence and clinical significanceDie Behandlung der sackförmigen intrakraniellen AneurysmenAcute Hemorrhage into Pituitary Adenomas 1 May 1936Volume 9, Issue 11Page: 1595-1603KeywordsHospital medicineInsulin ePublished: 1 December 2008 Issue Published: 1 May 1936 PDF downloadLoading ...
Host stroma determines the tumor response to radio-inducible TNF-alpha based gene therapy
Authors: Helena J. Mauceri, Michael A. Beckett, Samuel Luka, Thomas E. Darga, Ralph R. Weichselbaum
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4027 

Combination treatment with the radio-inducible adenoviral vector Ad.Egr-TNF (TNFerade™) and ionizing radiation (IR) produces synergistic anti-tumor effects in pre-clinical tumor models. Safety and efficacy have been demonstrated in phase I and phase 2 clinical trials. To test the hypothesis that host stroma determines the tumor response to Ad.Egr-TNF+IR we compared the effects of treatment on B16-F1 melanoma tumors growing in wild-type C57BL/6 and TNF receptor 1, receptor 2 deficient (TNFR−/−) mice. C57BL/6 or TNFR−/− mice were injected in the hind limb subcutaneously with 1× 106 B16-F1 melanoma cells. 7-10 days later tumors reached a mean volume of 368.4 ± 33.6 mm3 (C57BL/6) and 355.4 ± 45.9 mm3 (TNFR−/−) respectively. Treatment began at day 0 at which time tumors were divided in 4 treatment groups: control (viral buffer, days 0, 1), IR (20 Gy, day 1, viral buffer, days 0, 1), vector alone (2×109 p.u. Ad.Egr-TNF, days 0, 1), vector + IR (Ad.Egr-TNF, 2×109 p.u., days 0, 1, and 20 Gy, day 1). 10μl of viral buffer or Ad.Egr-TNF were injected intratumorally (IT) using a Hamilton syringe. Untreated tumors in C57BL/6 hosts exhibited a 10-fold increase in tumor volume by day 8. Equivalent growth was observed in vector treated tumors (10.2-fold increase, day 8) at which time animals in both groups were sacrificed due to tumor burden. Tumors treated with Ad.Egr-TNF+IR were significantly smaller compared with IR alone (4.3 vs 10.8, day 11, p=0.04) In TNFR−/−mice, untreated and vector treated tumors exhibited equivalent growth similar to that observed in wild-type C57BL/6 hosts. However, no significant anti-tumor effects were detected following combined treatment with Ad.Egr-TNF+IR (10.4-fold increase) compared with IR alone (9.6-fold increase, day 11) in TNFR−/− hosts. These results demonstrate that TNF-α protein induced by IR requires intact host TNF receptors to achieve anti-tumor effects and suggest that the tumor stroma is a target for radio-inducible gene therapy. Supported by NIH Grant CA-111423 (RRW)
Hospitalization for Pneumonia and Risk of Cardiovascular Disease—Reply
Authors: Vicente F. Corrales-Medina, Karina N. Alvarez, Sachin Yende
Journal: JAMA (2015)

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Mammary Tumor Virus in Strain GR Mice in Relation to Age and Tissue Type 2
Authors: John M. Shannon, Bruce D. Aidells, C. W. Daniel
Journal: JNCI Journal of the National Cancer Institute (1974)

Normal and neoplastic mammary tissues of GR/Crgl mice were examined for the presence of mammary tumor virions. Detection of both B and cytoplasmic A particles in normal glands from mice 2 weeks of age and older was the earliest reported occurrence of such particles. Virus particles were not found in normal tissues from mice 24 hours or 1 week old. All neoplastic tissues examined had moderate or abundant virus particles. The possible relationship of these results to the mode of viral transmission was discussed.
Abstract 4478: Local Determinants and Clinical Significance of Thrombus Formation Following Sirolimus-Eluting Stent Implantation: Insights from Optical Coherence Tomography Analysis
Authors: Hiromasa Otake, Junya Shite, Junya Ako, Toshiro Shinke, Takahiro Sawada, Koo Bon-Kwon, Paul G Yock, Yasuhiro Honda, Peter J Fitzgerald, Ken-ichi Hirata
Journal: Circulation (2008)

Angioscopic analyses have shown the presence of subclinical thrombus in sirolimus-eluting stents (SES) is more common than the clinical incidence of stent thrombosis. However, the determinants and long term significance of subclinical thrombus remain unknown. Thirty five patients (44 stents) who received SES underwent 6 months follow-up optical coherence tomography (OCT). Patients were divided into 2 groups according to the presence of thrombus by OCT. Cross-sectional images were analyzed every 1mm. Stent eccentricity index (SEI; minimum stent diameter divided by maximum stent diameter) was determined in each cross section (CS). To assess the unevenness of neointimal thickness (NIT), a neointimal unevenness score (NUS) was calculated for each CS as maximum NIT in the CS divided by the average NIT of the same CS. Average SEI and NUS were also calculated for each stent. Major adverse cardiac event (MACE) was defined as a composite of death, myocardial infarction, and target vessel revascularization. Eight cases of thrombus were detected by OCT (18%). The thrombus cases were associated with longer stent length, larger numbers of uncovered struts, smaller average SEI, and greater average NUS (Table ). A significant relationship existed between the average SEI and average NUS ( P &lt;0.0001, R=0.66), as well as between average SEI and the number of uncovered struts ( P =0.005, R=0.47). There was no significant difference in MACE during follow-up (median: 655days) (Thrombus: 0%, Non-thrombus: 7.4%, P=0.43). Based on OCT, longer stents, a larger number of uncovered stent struts, asymmetric stent expansion, and unevenness of NIT may be important determinants of thrombus formation in patients treated with SES. Asymmetric stent expansion may interfere with even neointimal coverage after SES deployment, perhaps a key mechanism for thrombus formation. In this small cohort, the presence of thrombus did not seem to increase the risk of MACE.