tbuckley/cabot-search huggingface dataset:
Granulocytes and Three-Phase Bone Scintigraphy for Differentiation of Diabetic Gangrene with and Without Osteomyelitis
Authors: Michael M Ritter, Werner O Richter, Gerda Leinsinger, Carl Martin Kirsch, Peter Schwandt
Journal: Diabetes Care (1992)

In diabetic gangrene, concomitant osteopathy and soft-tissue infection often render laboratory and roentgenographic signs unreliable as indicators of osteomyelitis. In this situation, scintigraphic methods can be helpful.Relying on the long-term clinical course as the final indicator of presence or absence of osteomyelitis, we prospectively compared in 31 patients three-phase bone scintigraphy with either indium-labeled autologous granulocytes (n = 20) or 123I-labeled antibodies against granulocytes (n = 11).Three-phase bone scintigraphy and imaging with indium-labeled autologous granulocytes yielded sensitivities and specificities of 95 and 70% for bone scintigraphy and 77 and 100% for granulocyte scintigraphy, respectively. One patient with severe angiopathy and proved osteomyelitis had a negative bone scintigraphy but a positive scintigraphy with labeled antibodies against granulocytes. One patient with aseptic bone necrosis presented with a formally false positive result with both methods.In contrast to former retrospective studies, three-phase bone scintigraphy compares very well with granulocyte scintigraphy. The care of most patients can be managed with clinical data and this widely available scintigraphic method.
HEMORRHAGE AFTER CONFINEMENT AND ITS TREATMENT.
Authors: HERMAN E. HAYD
Journal: JAMA (1900)

Hemorrhages at all times and under all conditions are matters of serious import; they signify responsibilities more or less grave, according to the organs involved and the amount of blood actually lost. Mere loss of blood, however, as measured and interpreted by ounces, does not necessarily indicate serious involvement of structure or function; and if not sudden and overwhelming in amount, this loss is in many individuals without apparent effect upon the economy, so quickly is the lost amount replaced by a new supply. At the same time, it is often surprising to see what inroads are made upon the system by small and repeated losses of blood continued only for a short period of time. Hemorrhage after confinement presents itself in many interesting and important forms; and often demands the greatest skill and the best resources of the most accomplished medical man. Indeed, I can imagine no condition more
Augmentation of renal blood flow and sodium excretion in hypertensive patients during blood pressure reduction by intravenous administration of the dopamine1 agonist fenoldopam.
Authors: M B Murphy, C E McCoy, R R Weber, E D Frederickson, F L Douglas, L I Goldberg
Journal: Circulation (1987)

Activation of dopamine1 (DA1) receptors relaxes vascular smooth muscle, especially in the renal vascular bed. Fenoldopam, the first selective DA1-receptor agonist that can be administered to man, was infused intravenously in 17 patients with essential hypertension (mean blood pressure 152/101 mm Hg). It reduced blood pressure in a dose-dependent fashion at doses between 0.025 and 0.5 microgram/kg/min and the antihypertensive effect was sustained during 2 hr infusions. In 10 patients studied during free-water diuresis, fenoldopam increased renal plasma flow by 42%, glomerular filtration rate by 6%, and sodium excretion by 202%, while lowering mean arterial pressure by 12% (all p less than .05). Similar promotion of sodium excretion was observed during blood pressure reduction in six additional patients studied without water loading. Pronounced enhancement of renal function in spite of blood pressure reduction suggests that fenoldopam might have a special role in the treatment of patients with hypertension and renal impairment.
687 SERUM IP-10 LEVEL ASSOCIATED WITH HEPATOCELLULAR CARCINOMA DEVELOPMENT IN PATIENTS WITH CHRONIC HEPATITIS B
Authors: H.-I. Yang, Y.-C. Chien, M.-H. Lee, J. Liu, H.-Y. Chen, C.-J. Liu, C.-L. Jen, D. Tsai, R. Batrla-Utermann, U. Iloeje, P.-J. Chen, C.-J. Chen
Journal: Journal of Hepatology (2013)
Gene Conversion Mutation in Crystallin, β-B2 (CRYBB2) in a Chilean Family with Autosomal Dominant Cataract
Authors: J. Bronwyn Bateman, Fernando R. Barria von-Bischhoffshaunsen, Leslie Richter, Pamela Flodman, Douglas Burch, M. Anne Spence
Journal: Ophthalmology (2007)
THE PHYSICIANS' HOME ASSOCIATION
Authors: Wolff Freudenthal
Journal: JAMA (1923)

<h3>To the Editor:</h3> —While traveling this summer I met a number of physicians, with whom I discussed the necessity or desirability of one or more homes for physicians who are without any financial means and too old or disabled to help themselves. Most physicians are not aware that such an institution already exists in the state of New York, and that four physicians are being cared for. As a member of auxiliary committees of various medical societies, I had occasion for many years to come in contact with men who, for some reason or other, had lost everything and were without finances and without a home. Some, but very few, were not deserving of any support. Others were men of high character of whose integrity there was no doubt. Often I was at a loss how to help and what to do, when the small allotted pecuniary help that medical
QOL benefits observed as early as week 2 with peginterferon alfa-2a (40KD) (PEGASYS) in combination with ribavirin (RBV) versus interferon alfa-2b plus RBV
Authors: T.I. Hassanien, W.G.E. Cooksley, M. Sulkowski, C. Smith, G. Marinos, M.-Y. Lai, G. Pastore, R. Trejo-Estrada, A. Horta, E. Vale, N.S. Winfield, M. Neary, J. Green
Journal: Journal of Hepatology (2002)
Pancreatic islet cell surface glycoproteins containing Gal beta 1-4GlcNAc-R identified by a cytotoxic monoclonal autoantibody.
Authors: Y Uchigata, S L Spitalnik, O Tachiwaki, K F Salata, A L Notkins
Journal: The Journal of Experimental Medicine (1987)

To investigate the autoimmune pathogenesis of spontaneously occurring diabetes mellitus in BB rats, spleen cells of newly diagnosed diabetic BB rats were fused with mouse myeloma cells. Hybridoma supernatants were screened for antibodies by indirect immunofluorescence and by 51Cr-release assays using the RINm5F rat insulinoma cell line. One clone, E5C2, produced an IgM kappa antibody that was cytotoxic for RINm5F cells, but not for other rat cell lines nor for primary rat islet cells. However, treatment of primary rat islet cells with neuraminidase exposed surface antigens and rendered the cells susceptible to complement-mediated lysis by antibody E5C2. Using immunostaining of glycolipids separated by thin-layer chromatography, hapten inhibition assays with defined carbohydrates, and Western blots, the antigens recognized by E5C2 on RINm5F cells were identified as glycoproteins with molecular weights of 60,000 and 68,000. The antibody recognizes a carbohydrate antigen containing the sequence Gal beta 1-4GlcNAc-R, which on RINm5F cells is predominantly hidden by covalently bound sialic acid. These studies raise the possibility that hidden antigenic determinants on islet cells exposed by a variety of means may be the target of autoimmune attack.
The Challenge of Deadopting Low-Value Care
Authors: Frederic H. Schwartz
Journal: Annals of Internal Medicine (2014)

Letters2 December 2014The Challenge of Deadopting Low-Value CareFrederic H. Schwartz, MDFrederic H. Schwartz, MDFrom University of Massachusetts School of Medicine, Worcester, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read Drs. Roman and Asch's essay (1) with great interest and wish to share my perspective on runaway health care costs and their sources within the internal medicine community. Although psychological forces may be at play in the deadoption of chemotherapeutic agents, procedures, and technologies, I do not believe they are an important factor in causing runaway costs. Rather, the major cause is the pervading culture that emanates from what Dr. Arnold Relman described as the “medical–industrial complex” (2). The American College of Physicians has taken a bold and important initiative with their new emphasis on ...References1. Roman BR, Asch DA. Faded promises: the challenge of deadopting low-value care. Ann Intern Med. 2014;161:149-50. [PMID: 24781317] doi:10.7326/M14-0212 LinkGoogle Scholar2. Relman AS. The new medical-industrial complex. N Engl J Med. 1980;303:963-70. [PMID: 7412851] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Massachusetts School of Medicine, Worcester, Massachusetts.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L14-0414. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFaded Promises: The Challenge of Deadopting Low-Value Care Benjamin R. Roman and David A. Asch Faded Promises: The Challenge of Deadopting Low-Value Care Benjamin R. Roman and David A. Asch The Challenge of Deadopting Low-Value Care Benjamin R. Roman and David A. Asch The Challenge of Deadopting Low-Value Care Benjamin R. Roman and David A. Asch Metrics Cited byThe complex interface between economy and healthcare: An introductory overview for clinicians 2 December 2014Volume 161, Issue 11Page: 842-843KeywordsGraduate medical educationHIVHealth careLyme diseaseMagnetic resonance imagingMedical educationNursesPatients ePublished: 2 December 2014 Issue Published: 2 December 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
P142 Pedometer and activity monitor step count reliability compared to visual during walking in patients with chronic respiratory disease
Authors: L. J. Turner, L. Houchen, S. Singh
Journal: Thorax (2011)

<h3>Introduction</h3> Chronic respiratory disease (CRD) is associated with reduced physical activity (PA), which pulmonary rehabilitation (PR) can improve. There are a variety of devices which monitor PA. Activity monitors (AM) are relatively small devices which utilise several accelerometers, temperature sensors and the galvanic skin response to provide data regarding energy expenditure, metabolic equivalents and step counts. However, AM9s are expensive compared to pedometers and do not provide instant feedback. Our aim was to assess the reliability of step counting by pedometers and AM9s compared to visual counts at varying walking speeds in patients with CRD. <h3>Methods</h3> 48 patients with CRD wore a Yamax pedometer and a Sensewear Pro<sup>3</sup> AM during an ESWT as part of their PR discharge assessment. Speeds were calculated from ISWT and patients had performed the ESWT at baseline, in line with standardised guidelines. Patients requiring walking aids were excluded. Step counts were measured by the pedometer, AM and visually by a separate assessor. Visual step counts were considered “gold-standard” for comparison. For analysis, average step counts for 1 min were calculated at slow, medium and fast speeds. A Friedman9s ANOVA test with post-hoc Wilcoxon signed rank was used to compare visual step counts to the pedometer and AM, as the data were not normally distributed. <h3>Results</h3> The Friedman9s ANOVA demonstrated there was a significant difference between the pedometer, AM and visual step counts at slow (p=0.0001) and medium (p=0.009) speeds but not at fast speeds (p=0.174). Abstract P142 table 1 demonstrates where the differences are between the pedometer, AM and visual step counts from the Wilcoxon signed rank test. <h3>Conclusions</h3> At slow and medium walking speeds, there was a significant difference between visual counts and the pedometer and AM. There was also a significant difference between the AM and pedometer at slow speeds. At fast walking speeds there was no significant difference between the visual, pedometer and AM step counts. Overall, both the pedometer and AM underestimated steps at slow and medium walking speeds and are therefore not be suitable for use in patients with CRD who often walk slowly.
I've Been over into the Future
Authors: Frank Davidoff
Journal: Annals of Internal Medicine (1995)

Editorials15 October 1995I've Been over into the FutureFrank Davidoff, MDFrank Davidoff, MDEditorSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-8-199510150-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Editorials several months ago heralded the arrival of a new publication [1, 2]. Now it's here.Evidence-Based Medicine will look familiar to readers of ACP Journal Club, upon which it is modeled. According to its statement of purpose, Evidence-Based Medicine is designed to “alert clinicians to important advances in internal medicine, general and family practice, surgery, psychiatry, paediatrics, and obstetrics and gynaecology by selecting from the biomedical literature those original and review articles whose results are most likely to be both true and useful.” Selection according to tough, explicit criteria for quality of the evidence is the key to this ...References1. Davidoff F, Haynes B, Sackett D, Smith R. Evidence-based medicine. A new journal to help doctors identify the information they need. BMJ. 1995; 310:1085-6. Google Scholar2. Davidoff F, Case K, Fried PW. Evidence-based medicine: why all the fuss? Ann Intern Med. 1995; 122:727. Google Scholar3. “Purpose and procedure. Evidence-Based Medicine. 1995 Nov-Dec; 1:2.” Google Scholar4. “Specialist inpatient stroke unit care reduces mortality and institution-alisation compared with general medical ward care [abstract]. Evidence-Based Medicine. 1995 Nov-Dec; 1:11. Abstract of: Stroke Unit Trialists' Collaboration. A systematic review of specialist multidisciplinary team (stroke unit) care for stroke inpatients. The Cochrane Database of Systematic Reviews. 1995, issue 1.” Google Scholar5. Fullerton-Smith I. How members of the Cochrane Collaboration prepare and maintain systematic reviews of the effects of health care. Evidence-Based Medicine. 1995 Nov-Dec; 1:7-8. Google Scholar Author, Article, and Disclosure InformationAffiliations: Editor PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1995Volume 123, Issue 8Page: 629KeywordsElectronic medical recordsEvidence based medicineForecastingHealth information technologyInpatientsStrokeSurgerySystematic reviews Issue Published: 15 October 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Choosing the right outcomes
Authors: M. Silverman
Journal: Allergy (1999)

Outcome measures are used to monitor the effects of interventions in clinical practice or in formal clinical trials. They may also be used to assess changes within populations either spontaneously or as a result of public-health measures. They are used to monitor the course of illness as part of a management plan or, for larger groups, to identify changes brought about, for instance, by migration or immunization. The choice of outcome measure depends on the age of the child, the complexity of the outcome (for instance, whether its application is to individuals or populations), and the time scale over which it is necessary to detect changes in outcome. The most commonly used outcome measures are clinical symptoms, which are often compiled into scoring systems. Surprisingly, these are often the least well-validated measures of outcome. Physiologic measures, although well validated, are difficult to apply to infants and pre-school children. The role of inflammatory markers is currently limited to research rather than clinical practice. Other outcome measures such as quality of life, impact-of-asthma instruments, and measures to determine the health-economic aspects of asthma are poorly developed in childhood. The right outcome depends on the question being asked, the age of the subjects, and the time scale and complexity over which measurement is required.
WMA protests at claim that it planned to expel Israeli doctors
Authors: L. Eaton
Journal: BMJ (2002)

An international row has broken out after reports in the Jerusalem Post last month said that the World Medical Association (WMA) might be considering expulsion of the Israel Medical Association—a rumour vehemently denied by the WMA.

The WMA and other health organisations around the world have received thousands of protesting email messages from Jewish doctors worldwide after the press report. The emails even crashed the WMA's computer system.

But the WMA, which held its council …
Aquagenic syringeal acrokeratoderma: unusual prominence on the dorsal aspect of fingers?
Authors: T.Y. Yoon, K.R. Kim, J.Y. Lee, M.K. Kim
Journal: British Journal of Dermatology (2008)

Journal Article Aquagenic syringeal acrokeratoderma: unusual prominence on the dorsal aspect of fingers? Get access T.Y. Yoon, T.Y. Yoon Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar K.R. Kim, K.R. Kim Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar J.Y. Lee, J.Y. Lee Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar M.K. Kim M.K. Kim Internal Medicine, School of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Chungbuk 361‐763, Korea E‐mail: tyyoon@chungbuk.ac.kr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 159, Issue 2, 1 August 2008, Pages 486–488, https://doi.org/10.1111/j.1365-2133.2008.08633.x Published: 01 August 2008
Patients Affected by Changes to Hypertension Guideline
Authors: Karen L. Margolis
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein
Authors: Gao Huile, Pan Shuaiqi, Yang Zhi, Cao Shijie, Chen Chen, Jiang Xinguo, Shen Shun, Pang Zhiqing, Hu Yu
Journal: Biomaterials (2011)
Postischemic injury, delayed function and Na+/K+-ATPase distribution in the transplanted kidney
Authors: Veludina S.J. Alejandro, W. James Nelson, Phil Huie, Richard K. Sibley, Donald Dafoe, Paul Kuo, John D. Scandling, Bryan D. Myers
Journal: Kidney International (1995)

We are pleased to announce the publication of the ISN World Congress of Nephrology 2020 Meeting Abstracts. The abstracts are freely accessible to all.
Papillary necrosis in a transplanted kidney.
Authors: C Leroux-Robert, A Meyrier, L Morel-Maroger, J D Sraer
Journal: BMJ (1972)

IL-1β is an important proinflammatory cytokine with a major role in several inflammatory diseases. Expression of IL-1β is tightly regulated at the level of transcription, mRNA stability, and proteolytic processing. In this study, we report that IL-1β expression in response to LPS is also regulated at the translational level. LPS-induced IL-1β protein levels in macrophages derived from murine bone marrow are markedly increased in the absence of tyrosine kinase 2 (Tyk2). Increased IL-1β is found intra- and extracellularly, irrespective of the efficiency of IL-1β processing. We show that the absence of Tyk2 results both in higher translational rates and in enhanced association of IL-1β mRNA with polysomes. Induction and stability of IL-1β mRNA are not affected by the lack of Tyk2. We show further that the Tyk2-dependent translational inhibition is mediated by autocrine/paracrine type I IFN signaling and requires signal transducer and activator of transcription 1. Enhanced IL-1β production in Tyk2- and IFN receptor 1-deficient macrophages is also observed following <i>Listeria monocytogenes</i> infection. Taken together, the data describe a novel mechanism for the control of IL-1β synthesis.
ABLATION OF PERI-MITRAL FLUTTER AFTER ABLATION OF LONG STANDING PERSISTENT AF: RESULTS FROM THE PROPOSE MULTICENTER STUDY
Authors: Luigi Di Biase, Rong Bai, Prasant Mohanty, Antonio Dello Russo, Michela Casella, Gemma Pelargonio, Sakis Themistoclakis, Sanghamitra Mohanty, Claude S. Elayi, Javier E. Sanchez, David J. Burkhardt, Rodney Horton, G. Joseph Gallinghouse, Shane Bailey, Aldo Bonso, Salwa Beheiry, Richard Hongo, Antonio Raviele, Claudio Tondo, Andrea Natale
Journal: Journal of the American College of Cardiology (2011)
Reliability of Subjective Circulation Time Determinations
Authors: MURRAY M. MAHL, KURT LANGE
Journal: Circulation (1958)

When the fully objective dermofluorographic method of measurement of circulation time was compared with the subjective Decholin and saccharin methods, it was found that the values obtained with the subjective methods were often unreliable. The error was unpredictable in magnitude and occurrence, and was maximal in patients with failure.
Smoking Cessation: The Side Effects of Clonidine
Authors: Philip Tønnesen
Journal: JAMA (1989)

<h3>To the Editor. —</h3> In a recently published double-blind, placebo-controlled trial<sup>1</sup>of smoking cessation, 38 heavy smokers received clonidine and 42 received a placebo. There was a significantly better effect with clonidine compared with the placebo on the outcome after 6 months of treatment, with a success rate of 27% in the clonidine group compared with 5% in the placebo group. Clonidine treatment was stopped in 3 (8%) of the 38 subjects owing to sedative effects and treatment was discontinued in 2 (5%) of the 42 placebo-treated subjects (difference not significant). The dose of clonidine was 150 to 300 μg/d. When this study was published, we had almost finished an open clinical trial with clonidine in smoking cessation. This study comprised 47 subjects (37 women and 10 men) with a median age of 45 years (range, 21 to 70 years). Their cigarette consumption was 20 cigarettes daily (range, 10