Factor VIII and Renal Disease
Authors: DANIEL R. AMBRUSO
Journal: Annals of Internal Medicine (1977)

Letters and Corrections1 November 1977Factor VIII and Renal DiseaseDANIEL R. AMBRUSO, M.D., DENNIS P. DURANTE, M.D., RAWLE M. MCINTOSH, M.D., WILLIAM E. HATHAWAY, M.D.DANIEL R. AMBRUSO, M.D.Search for more papers by this author, DENNIS P. DURANTE, M.D.Search for more papers by this author, RAWLE M. MCINTOSH, M.D.Search for more papers by this author, WILLIAM E. HATHAWAY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-5-636 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recent studies (1-3) have indicated that levels of factor VIII are increased in chronic renal disease. One study (3) in which patients were seen over a period of 4 years showed that increased factor VIII levels at the time of diagnosis were associated with deteriorating renal functions, progressive renal disease, and poor prognosis. To explore these prognostic implications, we measured factor VIII levels in 32 patients (mostly children) who underwent percutaneous renal biopsies for nephrosis, disseminated lupus erythematosus with renal involvement, and vasculitis (anaphylactoid purpura) with renal involvement. The investigation of each child included factor VIII procoagulant...References1. THOMSONFORBESPRENTICEKENNEDY CCCA: Changes in blood coagulation and fibrinolysis in the nephrotic syndrome. Q J Med 63(171):399-407, 1974 Google Scholar2. EKBERGNILSSON MI: Factor VIII and glomerulonephritis. Lancet 1:1111-1113, 1975 CrossrefMedlineGoogle Scholar3. EKBERGNILSSONLINELL MIF: Significance of increased factor VIII in early glomerulonephritis. Ann Intern Med 83:337-341, 1975 LinkGoogle Scholar4. RUBINBARATT MT: Prognosis, in Pediatric Nephrology, edited by RUBIN MI. Baltimore, Williams & Wilkins Co., 1975, pp. 468-470 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Pediatrics University of Colorado Medical Center Denver, CO 80262 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByMarkers of Endothelial DamageEndothelial cell dysfunction correlates differentially with survival in primary and secondary pulmonary hypertensionCirculating von Willebrand Factor Antigen as a Predictor of Short-term Prognosis in Pulmonary HypertensionIncreased plasma von Willebrand factor in the systemic inflammatory response syndrome is derived from generalized endothelial cell activationVon Willebrand factor and factor XIII in children with Henoch-Schonlein purpuraImmunoquantitation of Von Willebrand factor (factor VIII-related antigen) in vinyl chloride exposed workersThe effect of radiation therapy on von Willebrand factor in patients with angiosarcomaLiteraturRENAL INVOLVEMENT IN MYELOMAFACTOR-VIII-RELATED ANTIGEN AND VASCULITISFactor VIII related antigen in the assessment of vasculitis.Hemostatic Abnormalities in Renal DiseaseIncreased Factor VIII related antigen in cerebral thrombosisFactor VIII Complex in chronic renal failure: Influence of protein C, fibrinolysis and diabetes mellitusIncreased factor VIII/von Willebrand factor antigen and von Willebrand factor activity in renal failureThe Biosynthesis of Factor VIII 1 November 1977Volume 87, Issue 5Page: 636-637KeywordsBiopsyChildrenLupus erythematosusRenal diseasesVasculitis Issue Published: 1 November 1977 PDF DownloadLoading ...