tbuckley/cabot-search huggingface dataset:
Papuloverrucous colloid milium: an occupational variant
Authors: L.M. Muscardin, M. Bellocci, L. Balus
Journal: British Journal of Dermatology (2000)

Journal Article Papuloverrucous colloid milium: an occupational variant Get access L.M. Muscardin, L.M. Muscardin Istituto San Gallicano and Luca M.Muscardin. E‐mail: Lucamusca@mclink.it Search for other works by this author on: Oxford Academic Google Scholar M. Bellocci, M. Bellocci Laboratory of Ultramicroscopy, Istituto San Gallicano, IRCCS, Via San Gallicano 25/a, Rome, Italy Search for other works by this author on: Oxford Academic Google Scholar L. Balus L. Balus Istituto San Gallicano and Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 143, Issue 4, 1 October 2000, Pages 884–887, https://doi.org/10.1046/j.1365-2133.2000.03798.x Published: 01 October 2000
Prostaglandin E2‐mediated immunosuppression and the role of albumin as its modulator
Authors: Won Hyeok Choe, Soon Koo Baik
Journal: Hepatology (2014)

1Department of Internal MedicineKonkuk University School of MedicineSeoulKorea 2Department of Internal MedicineYonsei University Wonju College of MedicineWonjuKorea
Increase of multi-sensitization to airborne allergens among adults from 1994 to 2009
Authors: Katja Warm, Helena Backman, Sigrid Sundberg, Anne Lindberg, Bo Lundbäck, Eva Rönmark
Journal: European Respiratory Journal (2011)

Aim:  To compare the prevalence of positive skin prick test (SPT) among adults in 1994 and 2009.   Methods:  In 1994 and 2009, random samples of participants from two cross-sectional postal questionnaire surveys were invited to clinical examinations including skin prick test (SPT) and structured interviews. Of invited in ages 20-60 years, 500 (68%) participated in 1994 and 463 (69%) in 2009. The SPT were performed with the same method with ten common airborne allergens. A wheal size of ≥ 3mm was considered as a positive reaction.   Results:  The prevalence of at least one positive SPT was 35% in 1994 and 39% in 2008 (p=0.13). The prevalence of positive SPT to the most common allergens increased significantly; birch (14% to 18%, p=0.03), timothy (12% to 21%, p   Conclusion:  The prevalence of sensitization to at least one allergen was similar in 1994 and 2009. However, the burden of allergic sensitization has increased as the proportion of subjects with multi sensitization increased. The clinical effect of this change needs to be analyzed.
Abstract 3625: Targeted Ultra-Small Iron Oxide Particles for In Vivo MR Detection of Atherosclerotic Lesions Using Antibodies against Oxidized Low Density Lipoprotein
Authors: Karen Briley-Saebo, Peter X Shaw, Claudia Calcagno, Seung-Hyuk Choi, Valentin Fuster, Sotirios Tsimikas, Zahi A Fayad
Journal: Circulation (2008)

Background: Oxidized low-density lipoprotein (OxLDL) plays a key role in the progression and destabilization of atherosclerotic plaque. Preliminary studies indicate that gadolinium (Gd) micelles labeled with oxidation-specific antibodies allow for specific targeting of vulnerable plaque. Due to issues associated with Gd toxicity (caused by retention and bio-transformation of the micelles), clinical translation of this platform may be limited. Iron oxides are recognized as safe and effective contrast agents for MRI. As a result, it was hypothesized that lipid coated ultra-small iron oxide particles (LUSPIOs) containing murine antibodies that bind malondialde-hyde lysine (MDA2) or oxidized phospholipids (EO6) associated with oxLDL may allow for the development of a safe platform for in vivo detection of vulnerable plaque. Materials and Results: Untargeted, MDA2, and EO6 labeled LUSPIOs were prepared and characterized with respect to efficacy, pharmacokinetics, and biodistribution in Apolipoprotein deficient mice (ApoE−/−). MRI was performed at 9.4T prior to and 24 hrs after LUSPIO administration (4 mg Fe/kg) using both gradient echo and positive contrast GRASP sequences. MDA2 and EO6 increased the particle size, blood half-life, and MR efficacy of the LUSPIOs, relative to untargeted particles. Only limited signal attenuation was observed following administration of untargeted LUSPIO. MRI and microscopy revealed that MDA2 and EO6 LUSPIOs accumulate within oxLDL rich foam cells (Fig.1 ). Conclusions: This study suggests that biocompatible LUSPIOs may provide a clinically translatable platform for the MR detection of oxLDL rich foam cells in humans. This research has received full or partial funding support from the American Heart Association, AHA National Center.
Lymphocytic interstitial pneumonia – Two cases of unusual presentation
Authors: Jorge Vale, Eloísa Silva, Vítor Melo, Jessica Jones, Rui Nunes, Antόnio Simões Torres
Journal: European Respiratory Journal (2011)

Background: The diagnosis of Lymphocytic Interstitial Pneumonia (LIP) is established by the demonstration of an exuberant lymphoid infiltration. The ATS/ERS statement includes it in the group of idiopathic interstitial pneumonias on the basis that rare cases of histopathological LIP pattern are truly idiopathic.  Case 1: 56-year old male admitted with hemoptysis. Thoracic imaging showed a 1,8 cm solitary nodule in the right upper lobe. Bronchoscopy was negative for malignancy. PET-CT Scan revealed increased uptake. Thoracic surgery and histology revealed dense lymphocytic infiltrate in alveolar septa. Further testing ruled out subjacent causes of LIP.  Case 2: 71-year old female admitted for progressive dyspnoea. Chest CT revealed lung fibrosis and honeycombing mainly in the upper lobes. There was decreased diffusing capacity. Bronchoalveolar lavage revealed lymphocitosis. The histological pattern obtained by surgical biopsy was consistent with LIP with areas of interstitial fibrosis. Secondary causes of LIP were excluded. Treatment with prednisolone was started with clinical and functional improvement.  Comment: LIP represents a benign polyclonal proliferation that can diffusely involve the lung or be a focal process. The combined presence of nodules, cysts and ground glass are suggestive of LIP. Presentation as a solitary pulmonary nodule is rare; it may represent focal involvement of the lymph proliferative disorder. Demonstration of the polyclonality of the usual B cell infiltrates distinguishes LIP from pulmonary lymphoma. Fibrosis is unusual in idiopathic LIP and could be due to long standing disease.The authors emphasize the unusual radiologic presentation of these two cases of idiopathic LIP.
Hair shaft abnormalities after chemotherapy and tamoxifen therapy in patients with breast cancer evaluated by optical coherence tomography
Authors: J. Lindner, K. Hillmann, U. Blume‐Peytavi, J. Lademann, A. Lux, A. Stroux, A. Schneider, N. Garcia Bartels
Journal: British Journal of Dermatology (2012)

Antineoplastic treatment for breast cancer is frequently associated with alopecia. Increasingly, changes in the texture and shape of regrowing hair after chemotherapy have been reported, without evaluation on a scientific basis. Optical coherence tomography (OCT) provides highly reproducible measurements of hair shaft parameters.This study aims to evaluate hair shaft alterations using OCT in chemotherapy-induced alopecia and in patients taking tamoxifen.The measurements of this prospective case series were performed on women aged 29-68 years, receiving either tamoxifen (n = 17) or chemotherapy (n = 17) prior to (T1) and after (T2) treatment. Each time, 20 hairs from two different sites of the scalp (frontal, occipital) were examined by OCT. The hair parameters were characterized by cross section (CS) and form factor (FF). The ratio of maximal to minimal hair diameters determined the FF.After chemotherapy, the CS of hairs was significantly lower compared with hairs taken at T1. The FF did not vary between T1 and T2 for the frontal area, but it did for the occipital area. In patients treated with tamoxifen, changes were observed neither in CS nor in FF. However, comparing both therapeutic groups, there were significant differences in CS and FF for T2, but not for T1.Reported changes in hair structure after chemotherapy may be due to reduction of hair shaft calibre and increase of FF in regrowing hair. The OCT technique is a promising method to gain more insight into chemotherapy-induced changes of hair morphology.
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt
Authors: Justin E Wilson, Alex S Petrucelli, Liang Chen, A Alicia Koblansky, Agnieszka D Truax, Yoshitaka Oyama, Arlin B Rogers, W June Brickey, Yuli Wang, Monika Schneider, Marcus Mühlbauer, Wei-Chun Chou, Brianne R Barker, Christian Jobin, Nancy L Allbritton, Dale A Ramsden, Beckley K Davis, Jenny P Y Ting
Journal: Nature Medicine (2015)
Comorbidities associated with sarcoidosis – Results from long-term observational study
Authors: Adam Nowinski, Elzbieta Puscinska, Anna Goljan-Geremek, Michal Bednarek, Dariusz Kaminski, Dorota Gorecka
Journal: European Respiratory Journal (2014)

Rationale: Sarcoidosis is a multisystem inflammatory disease of unknown etiology. Sarcoidosis may affect many tissues by the presence of noncaseating granulomas, but the inflammatory process can potentially trigger other comorbidities in sarcoid patients.  Aim: The aim of this study was to identify the prevalence of comorbidities in sarcoid patients.  Materials and methods: A cohort of 557 patients with histologically confirmed sarcoidosis diagnosed between 2007 and 2011 was observed. All patients were carefully examined for comorbidities.  Results: 291 males (52,2%) and 266 females (47,8%) with mean age 48,4 ±12,0 yrs were observed. Majority of studied patients had radiological stage II (62,1%) and stage III (20,8%) of the disease. Stage I was diagnosed in 14,1% patients and extrapulmonary involvement in 32,3% patients.  Most frequent of comorbidities were: hyperlipidemia N=121 (21,7%), obesity N=79 (14,2%), thyroid disease N=73 (13,1%), diabetes N=41 (7,4%), bronchiectases N=35 (6,3%), neoplasm N=33 (5,9%), osteoporosis N=32 (5,7%), anaemia N=26 (4,7%), coronary heart disease N=25 (4,5%), asthma N=21 (3,8%), gastric/duodenal ulcer N=16 (2,9%), allergy N=14 (2,5%), sleep apnea N=12 (2,2%), hypertension N=9 (1,6%), chronic renal disease N=6 (1,1%).  Conclusion: We have found significant number of comorbidities in patients with sarcoidosis. Screening for these conditions, especially thyroid and neoplastic disorders, should be considered in these patients.
Stevens-Johnson syndrome and toxic epidermal necrolysis in patients with malignancies
Authors: J. Wu, Y.Y. Lee, S.C. Su, T.S. Wu, K.C. Kao, C.C. Huang, W.C. Chang, C.H. Yang, W.H. Chung
Journal: British Journal of Dermatology (2015)

Malignancy is known to be associated with an increased mortality rate in patients with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). However, risk factors contributing to the poor prognosis of patients with SJS/TEN with malignancies remain undefined.To explore the potential involvement of malignancy and its related factors contributing to the poor outcome of SJS/TEN, in a retrospective study.In total 517 patients with SJS/TEN were enrolled. Forty-seven who sustained various types of malignancies were analysed for numerous malignancy-related factors, including cancer types, clinical stages and chemotherapies given or not before the onset of SJS/TEN.We found that the mortality rate of patients with SJS/TEN with malignancies was higher than that of patients without malignancies (32%, 15/47 vs. 8·5%, 40/470, respectively) (P < 0·001). The use of phenytoin was significantly higher in the malignancy group. The presence of hepatocellular carcinoma (80%, four of five; P < 0·001; odds ratio 43) and colorectal cancer (67%, two of three; P = 0·022; odds ratio 21·5) significantly increased the death rate of patients with SJS/TEN, whereas lung cancer and urothelial carcinoma did not. Patients who had received ongoing or recent chemotherapy showed higher mortality than those without chemotherapy (P = 0·022; odds ratio 4·95). Furthermore, among the 47 patients with SJS/TEN with malignancies, lower serum albumin, haemoglobin and platelet count were detected in the deceased patients than in the surviving patients before the onset of SJS/TEN.Our results suggest that several factors related to malignancies, such as specific cancer types, chemotherapy and malnutrition, may contribute to poor prognosis in patients with malignancies developing SJS/TEN.
Efficacy and Safety of a Novel Oral Inducer of Apolipoprotein A-I Synthesis in Statin-Treated Patients With Stable Coronary Artery Disease
Authors: Stephen J. Nicholls, Allan Gordon, Jan Johansson, Kathy Wolski, Christie M. Ballantyne, John J.P. Kastelein, Allen Taylor, Marilyn Borgman, Steven E. Nissen
Journal: Journal of the American College of Cardiology (2011)
Development of a simplified single-apheresis approach for peripheral-blood progenitor-cell transplantation in previously treated patients with lymphoma.
Authors: H M Jones, S A Jones, M J Watts, A Khwaja, W Mills, A Fielding, A H Goldstone, D C Linch
Journal: Journal of Clinical Oncology (1994)

PURPOSE The aims of this study were to develop a simplified, safe, and cost-effective peripheral-blood progenitor-cell (PBPC) mobilization protocol. PATIENTS AND METHODS Twenty-six patients with relapsed or resistant lymphomas were entered onto a sequential cohort study in which schedules of various granulocyte colony-stimulating factor (G-CSF) were administered after cyclophosphamide 1.5 g/m2. Hematologic recovery after high-dose carmustine (BCNU) etoposide, cytarabine, and melphalan (BEAM) chemotherapy was compared with that of 46 patients who received autologous bone marrow transplantation (ABMT) without growth factors and 28 patients who received ABMT followed by G-CSF. RESULTS When G-CSF (10 micrograms/kg/d) was administered from the day after the cyclophosphamide, neutropenia developed on day 8 followed by an abrupt increase in the WBC count. The optimal time for PBPC harvesting was the day on which the postnadir WBC count was greater than 8.0 x 10(9)/L, as shown by CD34+ cell counts and granulocytic-macrophage colony-forming cell (GM-CFC) assays. The reproducibility of the response was such that routine monitoring of CD34+ cell counts and GM-CFC was not necessary. A single leukapheresis on this day was adequate for prompt hematologic engraftment, and posttransplant G-CSF made little further impact on the rapid recovery. Compared with both control groups, the use of PBPC led to more rapid neutrophil recovery, markedly accelerated platelet recovery, less use of antimicrobial agents and parenteral nutrition, and more than 10 days earlier discharge from hospital. All of these differences were highly significant (P &lt; .01). CONCLUSION A simplified mobilization protocol is described that requires only one apheresis to achieve rapid hematologic engraftment.
LCI as an endpoint in COPD: Comparison with healthy controls, using SF6 and nitrogen washout
Authors: Alan Bell, James Dean, Dave Singh, Alex Horsley
Journal: European Respiratory Journal (2014)

Background   Lung Clearance Index (LCI) is well established in cystic fibrosis (CF), but has not been widely applied in other diseases. Commercial systems are available for SF 6  & nitrogen (N 2 ) multiple breath washout (MBW).   Objectives   LCI, FRC and test time were evaluated in COPD patients & healthy controls (HC) using 2 different validated washout devices to assess suitability as an outcome measure in COPD.   Methods   MBW was performed on the same day in triplicate using an indirect N 2  MBW system (Exhalyzer D) & a modified Innocor TM  SF 6  analyser, in random order. Results are expressed as mean (SD).   Results   11 COPD patients (age 62 (7.4) yrs, FEV 1  80 (4.9) %predicted), and 10 HC (26.9 (6.7)yrs, 101 (13.2) %predicted) were enrolled. 1 COPD subject was unable to perform N 2  MBW due to repeated leakage, and was excluded from comparison. In patients with COPD, LCI was greater than HC values in both systems. FRC-SF 6 =3.6 (0.9)L in COPD vs 3.3 (0.9)L in HC, p=ns. FRC-N 2 =3.9 (1.1)L in COPD vs 3.3 (2.3)L in HC, p=ns. LCI-SF 6 =10.2 (1.5) in COPD vs 6.3 (0.2) in HC, p 2 =11.9 (1.7) in COPD vs 7.0 (0.7) in HC, p 2  was significantly greater than LCI-SF 6  in COPD (limits of agreement -0.9 to 4.2, p=0.003) & HC (-0.4 to 1.6, p=0.006). Average total COPD test time was 41.2mins for triple N 2  MBW vs 40.9mins for SF 6  (p=ns).   Conclusions   Similar to observations in CF, LCI measured indirectly using N 2  washout was higher than SF 6  in COPD & controls. Both systems differentiated COPD from healthy subjects but success rates were higher for SF 6  MBW. Long test times were a feature of both systems. Reducing time taken to wash tracer in is a potential method of improving SF 6  MBW.
Comparative in vitro activity of oral antimicrobial agents against Enterobacteriaceae from patients with community-acquired urinary tract infections in three European countries
Authors: M. Kresken, B. Körber-Irrgang, D.J. Biedenbach, N. Batista, V. Besard, R. Cantón, M. García-Castillo, W. Kalka-Moll, A. Pascual, R. Schwarz, B. Van Meensel, H. Wisplinghoff, H. Seifert
Journal: Clinical Microbiology and Infection (2015)
ciliaFA: A free research tool for accurate, automated, high-throughput measurement of ciliary beat frequency (CBF)
Authors: Claire Smith, Jana Djakow, Petr Djakow, Alexandra Patel, Robert Hirst, Peter Andrew, Christopher O'Callaghan
Journal: European Respiratory Journal (2011)

Aim:  To develop a program that allows batch processing of multiple movie (.AVI) files for measurement of CBF.   Introduction:  A program was developed that converts average pixel intensities within a region of interest to a waveform. The waveform is analysed by fast fourier transformation (FFT) to extract the dominant frequency. The code runs on freeware (ImageJ) coupled to Microsoft Excel. It can be used with.AVI from any source, and has been developed for research use with cilia from the respiratory, fallopian or brain epithelia.   Methods:  Image files of 115 ciliated epithelial cell cultures were captured using a digital high-speed video recorder. In order to capture a range of CBF measurements, the bacterial toxin, pneumolysin, was used to inhibit CBF. Mean CBF measurements made by conventional frame by frame counting of ciliary beat cycles by slow motion playback were compared with those obtained using the automated ciliaFA system.   Results:  The mean (sd) difference between the ciliaFA and conventional methods was -0.4 (1.6) Hz, the correlation coefficient was shown to be 0.8 and the Bland-Altman limits of agreement were -3.5 to 2.7 Hz.   Conclusion:  The data showed that the ciliaFA software calculated consistent CBF measurements. The advantages of this system include automated, high throughput CBF analysis; whole field and individual region of interest measurements, and elimination of selection bias.
Evaluation of intensive postremission chemotherapy for adults with acute nonlymphocytic leukemia using high-dose cytosine arabinoside with L-asparaginase and amsacrine with etoposide.
Authors: M S Tallman, F R Appelbaum, D Amos, R S Goldberg, R B Livingston, J Mortimer, P L Weiden, E D Thomas
Journal: Journal of Clinical Oncology (1987)

In order to test the toxicity and efficacy of intensive postremission therapy with high-dose cytosine arabinoside with L-asparaginase and amsacrine with etoposide in adults with acute nonlymphocytic leukemia (ANL), 100 adults (ages 19 to 75) with previously untreated ANL were entered into a study using six sequential cycles of chemotherapy. Cycles 1 (induction), 3, and 5 included conventional doses of daunomycin, cytosine arabinoside, 6-thioguanine, vincristine (VCR), and prednisone. Cycle 2 was cytosine arabinoside 3 g/m2 intravenously (IV) every 12 hours for four doses, followed by L-asparaginase 10,000 U intramuscularly (IM) at hour 42; this combination was repeated 1 week later. Cycle 4 included amsacrine 120 mg/m2/d and etoposide 100 mg/m2/d, both IV for five days, and cycle 6 was three monthly courses of VCR on day 1, and prednisone, mercaptopurine, and methotrexate each for five days. Seventy-four patients (74%) achieved complete remission (CR) (51 with cycle 1 and 23 after cycle 2). The overall disease-free survival (DFS) for patients achieving CR is 27% at 3 years by Kaplan-Meier analysis, while for patients achieving CR with cycle 1 it is 34%. The actuarial probability of being free from relapse at 3 years for patients achieving CR is 34%. Sixteen of the 74 CR patients (22%) died in CR while continuing to receive intensive chemotherapy, including 12 (18%) who succumbed to infection (nine bacterial, three fungal). After a median follow-up of 20 months, 36 patients have relapsed and 21 remain alive in CR. Intensive consolidation with high-dose cytosine arabinoside, amsacrine, and etoposide can modestly prolong DFS compared with historical controls. However, relapse continued to be a major problem and, in addition, with more aggressive consolidation therapy, infection during marrow aplasia resulted in a significant number of deaths.
Telemetric right ventricular pressure measurements and serial echocardiography in experimental pulmonary arterial hypertension
Authors: Michiel Alexander de Raaf, Ingrid Schalij, Anton Vonk-Noordegraaf, Frances de Man, Harm Jan Bogaard
Journal: European Respiratory Journal (2012)

This study characterized hemodynamic changes in the Sugen-Hypoxia (SuHx) model by telemetric acquisition and echocardiography. The SuHx rat model is based on the combined exposure to the VEGF-receptor inhibitor SU5416 and hypoxia and is used in Pulmonary Arterial Hypertension (PAH) research due its histological features resembling the plexogenic pulmonary vascular remodeling seen in human PAH.  SU5416 (25 mg/kg s.c.) was administered and animals were housed at 10% oxygen for 4 weeks, followed by re-exposure to normoxic conditions. Telemetric right ventricular pressure acquisition was continuous from surgery onwards. Serial echocardiography was performed weekly under anesthetic conditions. Spearman correlations were calculated between echocardiographic parameters and telemetric RVSP.  Telemetric RVSP increased immediately after administration of SU5416 and exposure to hypoxia. In the consecutive re-exposure to normoxic conditions, a considerable interindividual variability was observed. Echocardiographic parameters as Tricuspid Annular Plane Systolic Excursion (TAPSE), Right Ventricular End Diastolic Diameter (RVEDD) and Pulmonary Artery Acceleration Time divided by cardiac cycle length (PAAT/cl) showed hypoxic adaptation, but post-hypoxic differences were less pronounced. RVEDD, but not PAAT/cl and TAPSE was significantly correlated to RVSP.  Telemetry and echocardiography both show a progressive response in the hypoxic period. Individual variability among animals resulted in different RVSP-responses upon re-exposure to normoxic conditions. RVEDD correlated significantly with RVSP, whereas TAPSE and PAAT/cl seemed not suitable as surrogate markers for RVSP.