THE RELATIONSHIP BETWEEN PERIARTERITIS NODOSA AND SARCOIDOSIS
Authors: A JACKSON, I KASS
Journal: Annals of Internal Medicine (1953)

Article1 February 1953THE RELATIONSHIP BETWEEN PERIARTERITIS NODOSA AND SARCOIDOSISALBERT JACKSON, M.D., IRVING KASS, M.D.ALBERT JACKSON, M.D.Search for more papers by this author, IRVING KASS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-2-288 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn their recent article, Churg and Strauss14 again called attention to the fact that they have found, in additional chronic cases of periarteritis nodosa, not only the typical vascular lesions but also extravascular granulomas.The purpose of this study is to review five autopsied cases of periarteritis nodosa and one case of sarcoidosis proved by biopsy. We would also like to consider the etiologic, clinical and histologic similarities between these two conditions, hitherto considered as distinctly separate entities.CASE REPORTSCase 1. This 21 year old white male was perfectly well until two days prior to admission, when he developed...Bibliography1. Adelson L: Periarteritis nodosa in infancy, J. Pediat. 39: 346, 1951. CrossrefMedlineGoogle Scholar2. Arkin A: Clinical and pathological study of periarteritis nodosa, Am. J. Path. 6: 401, 1930. MedlineGoogle Scholar3. BaggenstossShickPolley AHRMHF: Effect of cortisone on lesions of periarteritis nodosa, Am. J. Path. 27: 537, 1951. MedlineGoogle Scholar4. Baker LA: Periarteritis nodosa with report of two cases, Ann. Int. Med. 17: 223, 1942. LinkGoogle Scholar5. Banks BM: Is there a common denominator in scleroderma, dermatomyositis, disseminated lupus erythematosus, Libman-Sacks syndrome and polyarteritis nodosa? New England J. Med. 225: 433, 1941. CrossrefGoogle Scholar6. Barnumde TakatsDelkart DRGRE: Periarteritis nodosa following thiouracil therapy of hyperthyroidism, Angiology 2: 256, 1951. CrossrefMedlineGoogle Scholar7. Bergstrand H: Morphological equivalents in polyarthritis rheumatics, periarteritis nodosa, etc., J. Path. and Bact. 58: 399, 1946. CrossrefMedlineGoogle Scholar8. Berne RM: An unusual sensitivity reaction to penicillin: report of a case with autopsy findings, New England J. Med. 242: 814, 1950. CrossrefMedlineGoogle Scholar9. Boyd LJ: Periarteritis nodosa, abdominal manifestations, Bull. New York M. Coll., Flower and Fifth Ave. Hosps. 4: 27, 1941. Google Scholar10. Boyd LJ: Pulmonary manifestations of periarteritis nodosa, Bull. New York M. Coll., Flower and Fifth Ave. Hosps. 7: 94, 1944. Google Scholar11. Brudno JC: Chronic relapsing febrile nodular nonsuppurative panniculitis (Weber-Christian disease), New England J. Med. 243: 513, 1950. CrossrefMedlineGoogle Scholar12. Case records of the Massachusetts General Hospital (Case 36381), New England J. Med. 243: 454, 1950. CrossrefMedlineGoogle Scholar13. Case records of the Massachusetts General Hospital (Case 37511), New England J. Med. 245: 978, 1951. CrossrefMedlineGoogle Scholar14. ChurgStrauss JL: Allergic granulomatosis, allergic angiitis and periarteritis nodosa, Am. J. Path. 27: 277, 1951. MedlineGoogle Scholar15. Contratto AW: Periarteritis nodosa: a report of two cases, one with special reference to sensitivity factors, Arch. Int. Med. 80: 567, 1947. CrossrefGoogle Scholar16. Current Comment: Saranac symposium on the beryllium problem, J. A. M. A. 137: 648, 1948. Google Scholar17. CurtisGrekin ACRH: Sarcoidosis. III. A review, M. Clin. North America 33: 31, 1949. CrossrefMedlineGoogle Scholar18. Curtis GH: Cutaneous hypersensitivity due to beryllium: a study of 13 cases, Arch. Dermat. and Syph. 64: 470, 1951. CrossrefGoogle Scholar19. Diaz-RiveraMiller RSAJ: Periarteritis nodosa, a clinicopathologic analysis, Ann. Int. Med. 24: 420, 1946. LinkGoogle Scholar20. Downing JG: The use of ACTH and cortisone in dermatology, New England J. Med. 246: 56, 1952. CrossrefMedlineGoogle Scholar21. Dupont A: Un cas de bouton d'orient a structure de sarcoide de Boeck, Ann. de dermat. et syph. 1: 453, 1930. Google Scholar22. EasonCarpenter JG: Treatment of acute rheumatic polyarthritis with concentrated antiscarlatinal serum, Quart. J. Med. 30: 93, 1937. Google Scholar23. Ehrich WE: Nature of collagen diseases, Am. Heart J. 43: 121, 1952. CrossrefMedlineGoogle Scholar24. FinkelsteinBrewnan WPJ: Periarteritis nodosa, brief review and case report, Connecticut M. J. 7: 104, 1943. Google Scholar25. Forsham PH: Present status of ACTH and cortisone in therapy, M. Clin. North America 35: 1229, 1951. CrossrefMedlineGoogle Scholar26. FrazierHu CNCK: Isolation of Treponema pallidum from subcutaneous sarcoid, Proc. Soc. Exper. Biol. and Med. 30: 898, 1933. CrossrefGoogle Scholar27. Freiman DG: Sarcoidosis, New England J. Med. 239: 664-671, 709-716, 743-749, 1948. CrossrefMedlineGoogle Scholar28. FriedbergGross CKL: Periarteritis nodosa (necrotizing arteritis) associated with rheumatic heart disease, Arch. Int. Med. 54: 170, 1934. CrossrefGoogle Scholar29. Gartside IB: Granulomatous arteritis in lesions resembling sarcoidosis, J. Path. and Bact. 56: 61, 1944. CrossrefGoogle Scholar30. GelfandAronoff MLS: Periarteritis nodosa; possible relation to the increased usage of sulfonamides, Ann. Int. Med. 30: 919, 1949. LinkGoogle Scholar31. German WM: Lupoid-sarcoid induced by foreign body (silica), Am. J. Clin. Path. 10: 254, 1940. CrossrefGoogle Scholar32. Goodman MJ: Periarteritis nodosa with recovery: report of an unusual case apparently due to sensitivity to sulfadiazine, Ann. Int. Med. 28: 181, 1948. LinkGoogle Scholar33. Gruber GB: Zur Frage der Periarteritis nodosa, mit besonder Berucksichtigung der Gallenblasen und Nieren-Beteiligung, Virchows Arch. f. path. Anat. 247: 294, 1923. Google Scholar34. Gruber GB: Zur Frage der Periarteritis nodosa, Virchows Arch. f. path. Anat. 258: 441, 1925. CrossrefGoogle Scholar35. Harkavy J: Vascular allergy, III, J. Allergy 14: 507, 1942-43. CrossrefGoogle Scholar36. HarrisLynchO'Hare WAGWJP: Periarteritis nodosa, Arch. Int. Med. 63: 1163, 1939. CrossrefGoogle Scholar37. Harris WH: Etiology and pathology of periarteritis nodosa, South. M. J. 19: 426, 1926. CrossrefGoogle Scholar38. HarrellHorne GTSF: The reaction to Lepromin of patients with sarcoid or tuberculosis compared with that of patients in general hospital with a discussion of the mechanism of the reaction, Am. J. Trop. Med. 25: 523, 1945. CrossrefMedlineGoogle Scholar39. HelperinTrubek MM: Necrotizing arteritis and subacute glomerulonephritis in gonococcus endocarditis. Toxic origin of periarteritis nodosa, Arch. Path. 15: 35, 1933. Google Scholar40. Hermann W: Pulmonary changes in a case of periarteritis nodosa, Am. J. Roentgenol. 29: 607, 1933. Google Scholar41. HoppsWissler HCRW: The experimental demonstration of generalized arteritis and periarteritis (periarteritis nodosa), J. Lab. and Clin. Med. 31: 939, 1946. MedlineGoogle Scholar42. JohnsonHansonGood CCNOCA: Erythema nodosum: the possible significance of associated pulmonary hilar adenopathy, Ann. Int. Med. 34: 983, 1951. LinkGoogle Scholar43. Jones GM: Periarteritis nodosa with case reports, Ann. Int. Med. 16: 920, 1942. LinkGoogle Scholar44. KetronBernstein LWJC: Cutaneous manifestations of periarteritis nodosa, Arch. Dermat. and Syph. 40: 929, 1939. CrossrefGoogle Scholar45. King BG: The clinical diagnosis of periarteritis nodosa: report of 4 cases, Ann. Int. Med. 32: 466, 1950. LinkGoogle Scholar46. King CO: Post traumatic sarcoid-like lesions, South. M. J. 39: 122, 1946. CrossrefMedlineGoogle Scholar47. Kipkie GF: Possible role of infection in the production of periarteritis nodosa in hypertensive rabbits, Arch. Path. 50: 98, 1950. Google Scholar48. KipkieJohnson GFDS: Possible pathogenic mechanisms responsible for human periarteritis nodosa: as suggested by the occurrence of two instances of this disease in association with glomerulonephritis, Arch. Path. 51: 387, 1951. Google Scholar49. Kissmeyer A: La maladie de Boeck: Sarcoides cutanées benignes multiples, 1932, Masson et Cie, Paris, p. 147. Google Scholar50. Klein SP: Periarteritis nodosa, Arch. Int. Med. 54: 983, 1949. CrossrefGoogle Scholar51. KlempererPollockBaehr PADG: Diffuse collagen disease, J. A. M. A. 119: 331, 1942. CrossrefGoogle Scholar52. KlinefelterSalley HFSM: Sarcoidosis simulating glomerulonephritis, Bull. Johns Hopkins Hosp. 79: 333, 1946. MedlineGoogle Scholar53. KussmaulMeier AR: Ueber eine bisher nicht beschriebene eigenthumliche Arterienerkrankung (Periarteritis nodosa), die mit Morbus Brightii und rapid fortschreitender allgemeiner Muskellahmung einhergeht, Deutsch. Arch. f. klin. Med. 1: 484, 1866. Google Scholar54. LevinAdamsBeck MHWSWS: Prolonged treatment of cases of periarteritis nodosa with ACTH: effective dose as measured by metabolic balances, J. Clin. Endocrinol. 11: 343, 1951. CrossrefGoogle Scholar55. LichensteinFox LLJ: Necrotizing arterial lesions resembling those of periarteritis nodosa and focal visceral necrosis following administration of sulfathiazole: report of a case, Am. J. Path. 22: 665, 1946. Google Scholar56. LogueMullins RBF: Polyarteritis nodosa. Report of 11 cases with review of recent literature, Ann. Int. Med. 24: 11, 1946. LinkGoogle Scholar57. McCormick RV: Periarteritis occurring during propylthiouracil therapy, J. A. M. A. 144: 1453, 1950. CrossrefMedlineGoogle Scholar58. MatsugiSato MY: Über die allergisch Gewebsreaktion der Niere. Zugleich ein experimenteller Beitrag zur pathogenese der diffusen Glomerulonephritis und der Periarteritis nodosa, Virchows Arch. f. path. Anat. 293: 615, 1934. Google Scholar59. MiddletonMcCarter WSJS: The diagnosis of periarteritis nodosa, Am. J. M. Sc. 190: 291, 1945. CrossrefGoogle Scholar60. Motley L: Periarteritis nodosa with report of case showing unusual features and apparent recovery, J. A. M. A. 106: 898, 1936. CrossrefGoogle Scholar61. MundyWalkerRickermanBeck WLWGHAGJ: Periarteritis nodosa, report of a case treated with ACTH and cortisone, Am. J. Med. 11: 630, 1951. CrossrefMedlineGoogle Scholar62. OldRussell JWWD: Necrotizing pulmonary arteritis occurring with congenital heart disease (Eisenmenger complex): report of a case with necropsy, Am. J. Path. 26: 789, 1950. MedlineGoogle Scholar63. Ophuls W: Periarteritis acute nodosa, Arch. Int. Med. 32: 870, 1923. CrossrefGoogle Scholar64. Otani S: Zur Frage nach dem Wesen der sog. Periarteritis nodosa, Frankfurt. Ztschr. f. Path. 30: 208, 1924. Google Scholar65. Pagel W: Polyarteritis nodosa and "rheumatic" disease, J. Clin. Path. 4: 137, 1951. CrossrefMedlineGoogle Scholar66. ParkerWeiss FS: The nature and significance of the structural changes in the lungs in mitral stenosis, Am. J. Path. 12: 573, 1936. MedlineGoogle Scholar67. Pinner M: On etiology of sarcoidosis, Am. Rev. Tuberc. 54: 582, 1946. MedlineGoogle Scholar68. ProutyShafer MEL: Periarteritis nodosa associated with ratbite fever due to Streptobacillus moniliformis , J. Pediat. 36: 605, 1950. CrossrefMedlineGoogle Scholar69. ReimanPriceHubut HAAHPA: Trichinosis and periarteritis nodosa, differential diagnosis, possible relationship, J. A. M. A. 122: 274, 1943. CrossrefGoogle Scholar70. RichGregory AJE: Experimental demonstration that periarteritis nodosa is a manifestation of hypersensitivity, Bull. Johns Hopkins Hosp. 72: 65, 1943. Google Scholar71. Rich AR: The role of hypersensitivity in periarteritis nodosa, Bull. Johns Hopkins Hosp. 71: 123, 1942. Google Scholar72. Rich AR: Additional evidence of role of hypersensitivity in etiology of periarteritis nodosa, Bull. Johns Hopkins Hosp. 71: 375, 1942. Google Scholar73. Rich AR: Hypersensitivity to iodine as a cause of periarteritis nodosa, Bull. Johns Hopkins Hosp. 77: 43, 1945. Google Scholar74. Rich AR: Hypersensitivity in disease with especial reference to periarteritis nodosa, rheumatic fever, disseminated lupus erythematosus and rheumatoid arthritis in Harvey Lectures, 1946-1947, The Science Press Printing Co., Lancaster, Pa., p. 106. Google Scholar75. Riley EA: Boeck's sarcoid: a review based upon a clinical study of 52 cases, Am. Rev. Tuberc. 62: 231, 1950. MedlineGoogle Scholar76. RoseLitmannHoughton MHDJ: Polyarteritis nodosa, a clinical and pathological study and report of 6 cases, Ann. Int. Med. 32: 1114, 1950. LinkGoogle Scholar77. Rosenberg A: Etiologic and immunologic concepts regarding sarcoidosis, Arch. Dermat. and Syph. 64: 385, 1951. CrossrefGoogle Scholar78. Rosenthal SR: Pathological and experimental studies of Boeck's sarcoid, Am. Rev. Tuberc. 60: 236, 1949. MedlineGoogle Scholar79. RotenbergGuggenheim LA: Boeck's sarcoid: report of a case with renal involvement, Dis. of Chest. 8: 392, 1946. Google Scholar80. RubinPinner EHM: Sarcoidosis, Am. Rev. Tuberc. 49: 146, 1944. Google Scholar81. Rubin EH: Diseases of the chest, 1947, W. B. Saunders Co., Philadelphia, p. 310. Google Scholar82. SandlerMatthewsBornstein BPJHS: Pulmonary cavitation due to polyarteritis, J. A. M. A. 144: 754, 1950. CrossrefMedlineGoogle Scholar83. Selye H: Hormonal production of arthritis, J. A. M. A. 114: 201, 1944. CrossrefGoogle Scholar84. SelyePentz HEI: Pathological correlation between periarteritis nodosa, renal hypertension and rheumatic lesion, Canad. M. A. J. 49: 264, 1943. MedlineGoogle Scholar85. Selye H: General adaptations syndrome and disease of adaptation, J. Allergy 17: 358, 1946. CrossrefGoogle Scholar86. Selye H: Role of somatotrophic hormone in production of malignant nephrosclerosis, periarteritis nodosa, and hypertensive disease, Brit. M. J. 1: 263, 1951. CrossrefMedlineGoogle Scholar87. Selye H: The general adaptation syndrome and the disease of adaptation, J. Clin. Endocrinol. 6: 117, 1946. CrossrefGoogle Scholar88. ShickBaggenstossFullerPolley RMAHBFHF: Effects of cortisone and ACTH on periarteritis nodosa and cranial arteritis, Proc. Staff Meet., Mayo Clin. 25: 135, 1950. Google Scholar89. SilvermanWorthen JJJF: Agranulocytosis in a patient treated with mercurial diuretics, J. A. M. A. 148: 200, 1952. CrossrefMedlineGoogle Scholar90. SlingerStarck WNV: Cutaneous form of polyarteritis nodosa, Arch. Dermat. and Syph. 63: 641, 1951. Google Scholar91. SolomonKasichKiven SMN: Periarteritis nodosa with report of three cases diagnosed during life, Ann. Int. Med. 21: 638, 1944. LinkGoogle Scholar92. Staehelin HR: Zur Frage der Besnier-Boeck'schen Krankheit und der Periarteritis nodosa, Virchows Arch. f. path. Anat. 309: 235, 1942. CrossrefGoogle Scholar93. SweeneyBaggenstoss ARAH: Pulmonary lesions of periarteritis nodosa, Proc. Staff Meet., Mayo Clin. 24: 35, 1949. MedlineGoogle Scholar94. SymmersGillett WSR: Polyarteritis nodosa associated with malignant hypertension, disseminated platelet thrombosis, "wire loop" glomeruli, pulmonary silicotuberculosis and sarcoidosis-like lymphadenopathy, Arch. Path. 52: 489, 1951. Google Scholar95. Teilum G: Allergic hyperglobulinosis and hyalinosis (paramyloidosis) in reticulo-endothelial system in Boeck's sarcoid and other conditions: morphologic immunity reaction, Am. J. Path. 24: 389, 1948. MedlineGoogle Scholar96. Teilum G: Pathogenetic studies on lupus erythematosus disseminatus and related diseases, Acta med. Scandinav. 123: 126-142, 1946. CrossrefMedlineGoogle Scholar97. ThornRenoldWilsonFrawleyJenkinsGracia-HeyesForsham GWAEDTFDJPH: Clinical studies on the activity of orally administered cortisone, New England J. Med. 245: 549, 1951. CrossrefMedlineGoogle Scholar98. UrelesKalmansohn ALRB: Oral administration of cortisone in a case of erythema nodosum, New England J. Med. 245: 139, 1951. CrossrefMedlineGoogle Scholar99. VanceGraham BMJE: Periarteritis nodosa complicated by fatal intrapericardial hemorrhage, Arch. Path. 12: 521, 1931. Google Scholar100. Van Ordstrand HS: Current concepts of beryllium poisoning, Ann. Int. Med. 35: 1203, 1951. LinkGoogle Scholar101. Van WykHoffman JJCR: Periarteritis nodosa, a case of fatal exfoliative dermatitis resulting from "dilantin sodium" sensitization, Arch. Int. Med. 81: 605, 1948. CrossrefGoogle Scholar102. Vining CW: A case of periarteritis nodosa with subcutaneous lesions and recovery, Arch. Dis. Childhood 13: 31, 1938. CrossrefMedlineGoogle Scholar103. WechslerBender QSMD: Neurologic manifestations of periarteritis nodosa, J. Mt. Sinai Hosp. 8: 1071, 1942. Google Scholar104. Wegener F: Über generalisierte septische Gefasserkrankungen, Verhandl. d. deutsch. path. Gesellsch. 29: 202, 1936. Google Scholar105. Weiss S: Disease associated with inflammatory lesions of the peripheral arteries, New England J. Med. 225: 579, 1941. CrossrefGoogle Scholar106. Weinberg T: Granulomata of unknown etiology associated with periarteritis nodosa, Am. J. Path. 22: 645, 1946. MedlineGoogle Scholar107. WilensGlynn SLJ: Hypertensive and non-hypertensive periarteritis nodosa, Arch. Int. Med. 88: 51, 1951. CrossrefGoogle Scholar108. WilsonAlexander KSHL: Relation of periarteritis nodosa to bronchial asthma and other forms of human sensitiveness, J. Lab. and Clin. Med. 30: 195, 1945. Google Scholar109. WoldBaggenstoss LEAH: Gastro-intestinal lesions of periarteritis nodosa, Proc. Staff Meet., Mayo Clin. 24: 28, 1949. MedlineGoogle Scholar110. ZeekSmithWeeter PMCCJC: Studies on periarteritis nodosa. III. The differentiation between vascular lesions of periarteritis nodosa and of hypersensitivity, Am. J. Path. 24: 889, 1948. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Wadsworth, Kansas*Received for publication June 14, 1952.From the Veterans Administration Hospital, Wadsworth, Kansas. Reviewed in the Veterans Administration and published with the approval of the Chief Medical Director. The statements and conclusions published by the authors are the results of their own study and do not necessarily reflect the opinion or policy of the Veterans Administration. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPanarteriitis nodosaRadiological manifestations of neurosarcoidosis: Report of three cases and review of literatureIntramedullary spinal cord sarcoidosisHyperthermia, Fever and Infectious DiseasesThe Sarcoid Tissue Reaction: The Origin and Significance of Inclusion Bodies. Differential Diagnosis with Particular Delineation from Tuberculosis.SARCOIDOSIS WITH ERYTHRODERMIA AND ULCERATION.RETINOPATHY IN SARCOIDOSISMyokarditis und weitere MyokardiopathienKrankheiten der GefäßeGranulomatous Liver Disease, Functional Hepatic Insufficiency, and Disseminated Lupus ErythematosusPeriarteriitis nodosaRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (ELEVENTH RHEUMATISM REVIEW)* Part IIWILLIAM D. ROBINSON, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., WILLIAM S. CLARK, M.D., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D., F.A.C.P.Morbus BoeckMorbus BoeckEvidence for serologic hyper-reactivity in sarcoidosisDie pathologische Anatomie des Morbus BoeckIntracranial Boeck's Sarcoid Tumor Resembling MeningiomaPERIARTERITIS NODOSA: REPORT OF A CASE WITH BRAIN INVOLVEMENT*ZACHARY SAGAL, M.D., F.A.C.P.Sarcoidosis: A hypersensitivity diseaseTHE CLINICAL MANIFESTATIONS OF ESSENTIAL POLYANGIITIS (PERIARTERITIS NODOSA), WITH EMPHASIS ON THE HEPATIC MANIFESTATIONS*FRED H. MOWREY, F.A.C.P., EDWARD A. LUNDBERG, M.D. 1 February 1953Volume 38, Issue 2Page: 288-311KeywordsBiopsyGranulomasLesionsPathologistsSarcoidosis ePublished: 1 December 2008 Issue Published: 1 February 1953 PDF downloadLoading ...