OWREN'S CAPILLARY BLOOD THROMBOTEST FOR OFFICE OR BEDSIDE CONTROL OF ANTICOAGULANT THERAPY: AN EVALUATION
Authors: A J SEAMAN
Journal: Annals of Internal Medicine (1960)

Article1 November 1960OWREN'S CAPILLARY BLOOD THROMBOTEST FOR OFFICE OR BEDSIDE CONTROL OF ANTICOAGULANT THERAPY: AN EVALUATIONARTHUR J. SEAMAN, M.D., F.A.C.P.ARTHUR J. SEAMAN, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-5-914 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe coagulation proteins in the peripheral blood are in a state of dynamic equilibrium. All of those synthesized in the liver have a life span ranging from a few hours to a maximum of 14 days. The plasma values at any one moment, then, are the resultant of the rate of synthesis and the rate of degradation in both intra- and extravascular locations of these coagulation factors. The indirect anticoagulants act by inhibiting the rate of synthesis in the liver of the following coagulation proteins: prothrombin (II),‡proconvertin (VII), plasma thromboplastin component (IX), and Stuart factor (X). After the administration...Bibliography1. Wright IS: Concerning the functions and nomenclature of blood clotting factors, with a preliminary report of the profile of blood clotting factors in young males, Ann. Int. Med. 51: 841, 1959. LinkGoogle Scholar2. Quick AJ: The prothrombin in hemophilia and in obstructive jaundice, J. Biol. Chem. 109: lxxiii, 1935. Google Scholar3. Waaler B: Simultaneous contribution to the formation of thrombin by the intrinsic and extrinsic blood clotting systems, Scandinav. J. Clin. and Lab. Invest. 9: 322, 1957. CrossrefMedlineGoogle Scholar4. Owren PA: Thrombotest: a new method for controlling anticoagulant therapy, Lancet 2: 754, 1959. CrossrefMedlineGoogle Scholar5. Owren PA: The laboratory control of anticoagulant therapy in large groups of patients, Farmakoterapi 4: 92, 1959. Google Scholar6. OwrenAas PAK: The control of Dicumarol therapy and the quantitation determination of prothrombin and proconvertin, Scandinav. J. Clin. and Lab. Invest. 3: 201, 1951. CrossrefMedlineGoogle Scholar7. RodmanBarrowGraham NFEMJB: Diagnosis and control of the hemophilioid states with the partial thromboplastin (PTT) test, Am. J. Clin. Path. 29: 525, 1958. CrossrefMedlineGoogle Scholar8. Milstone SH: The problem of the lipid thromboplastins, Yale J. Biol. and Med. 22: 675, 1950. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, Oregon*Received for publication April 29, 1960.Presented at the Forty-first Annual Session of The American College of Physicians, San Francisco, California, April 7, 1960.†This work was supported in part by grants from the American Heart Association and the Oregon Heart Association‡Roman numerals in parentheses refer to the designations assigned by the International Committee on Coagulation Factor Nomenclature, Irving Wright, M.D., F.A.C.P., Chairman.1Requests for reprints should be addressed to Arthur J. Seaman, M.D., Associate Professor of Medicine, University of Oregon Medical School, Portland, Oregon. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProblems in the management of long-term anticoagulant therapy in coronary heart diseaseMethaemoglobin formation induced by thiolsComparison of the Thrombotest with the Modified Quick TestThe Control of Phenylindanedione TreatmentAn overview of anticoagulant therapy for coronary artery disease 1 November 1960Volume 53, Issue 5Page: 914-923KeywordsAnticoagulantsBlood plasmaCoagulation factorsFibrinogenHeartHemorrhageLiverPlasma proteinsProtein synthesisProteins ePublished: 1 December 2008 Issue Published: 1 November 1960 PDF downloadLoading ...