tbuckley/cabot-search huggingface dataset:
Abstract 10288: Revealing the Full Meaning of Lead aVR ST Changes in ST Elevation Myocardial Infarction
Authors: Cheuk-Kit Wong, Harvey D White, Hero investigators
Journal: Circulation (2010)

Background: For acute ST elevation myocardial infarction (AMI), we previously found higher mortality with dichotomously defined aVR ST elevation. As aVR is neither an anterior nor an inferior lead,...
Abstract 241: Pre- and Postshock Electrogram Features in Human VF and the Occurrence of Refibrillation
Authors: Elnaz Afatmirni, Marjan Khusa, Karthikeyan Umapathy, Stephane Masse, Krishnakumar Nair, Talha Farid, Sridhar Krishnan, Paul Dorian, Kumaraswamy Nanthakumar
Journal: Circulation (2011)

Background: During cardiac resuscitation, recurrence of VF (or refibrillation) is a common problem that could affect the survival rates. Predicting the occurrence of refibrillation by analyzing the pre-shock/post-shock waveform would enable the EMS personnel to administer anti-arrhythmic drugs that could prevent refibrillation and could help in optimizing resuscitation outcomes. Objective: To evaluate wavelet based features extracted from pre-shock waveform and QT interval measurements from post-shock waveform in predicting refibrillation. Method: The human VF database used in this study consisted of 14 successful, 7 refibrillation, and 13 unsuccessful out-of-the-hospital VF tracings extracted from the Zoll defibrillators recorded by the Toronto area EMS personnel. For the wavelet analysis (continuous wavelet transform) we used the 10s pre-shock waveforms from all the 34 cases that were not corrupted by the CPR artifacts. Wavelet features that indirectly measure signal (i.e., electrogram) complexity were extracted as features. A two stage classification was performed, in the first stage the 34 cases were classified into two classes i.e., CLASS I: 14 succ. + 7 refib. cases and CLASS II: 13 unsuccessful cases, and in the second stage the correctly classified CLASS I was further classified into succ. and refib. categories. The QT interval analysis used the first 3 beats of the post-shock waveforms of the 7 refib. cases and verified if a decrease in QT interval was observed. Results: For the first stage CLASS I and CLASS II categories, we obtained a classification accuracy of 76.5 % and for the second stage succ. and refib. categories, we obtained a classification accuracy of 75%. However considering only the prediction of refib., we could correctly classify 4 out of the 7 refib. cases. An automated pattern classifier was used for the pattern classification. The QT interval analysis did not yield conclusive results for this study. Conclusions: The pre-shock electrogram features demonstrate potential in predicting refibrillation while the post-shock electrogram features were inconclusive.
Abstract 13928: Adropin is a Novel Regulator of Endothelial Function Through the VEGFR2- PI3K-Akt and VEGFR2- Erk1/2 Pathways
Authors: Fina Lovren, Yi Pan, Adrian Quan, Krishna K Singh, Praphulla C Shukla, Mohammed Al-Omran, Hwee Teoh, Subodh Verma
Journal: Circulation (2010)

Adropin is a recently identified protein that has been implicated in the maintenance of energy homeostasis and insulin resistance. Inasmuch as vascular function and insulin sensitivity are closely ...
Recognition of depression and anxiety in primary care
Authors: A. Herran, J. L. Vazquez-Barquero, G. Dunn, T. Johnston, P. Talbot
Journal: BMJ (1999)

Surgical techniques should be fully evaluatedEditor-The editorial by Nicholson and Bradley on renal transplantation from living donors rightly pointed out that the United Kingdom has a lower rate of transplantations which use kidneys from living donors than the United States or Norway. 1 The recent report by the Royal College of Surgeons on organ transplantation in the United Kingdom recommended that steps should be taken to increase the use of kidneys from living donors in the United Kingdom to offset the shortage of cadaveric kidneys as well as to improve outcome. 2 In the United Kingdom in 1998, 38% more transplantations were performed using organs from living donors than in 1997.However, there is still some way to go if a level similar to that of the United States or Scandinavia (25-30%) is to be achieved.Nicholson and Bradley identify the risks associated with donor nephrectomy and state that much of the morbidity that occurs after open nephrectomy is related to the wound.For this reason they believe that the use of laparoscopically assisted donor nephrectomy needs to be examined in the light of the experience of, for example, the Johns Hopkins Hospital in Baltimore, Maryland.However, there have been no randomised prospective trials of this procedure, which takes longer than open nephrectomy.Furthermore, all of the non-randomised comparisons have been of open nephrectomy performed through a loin incision, with or without removal of a rib.If an anterior
Abstract 436: Lentiviral Vector-Mediated SERCA2 Gene Transfer Improved the Heart Failure and Left Ventricular Remodeling Induced by Myocardial Infarction in Rats
Authors: Kazuo Niwano, Masashi Arai, Yasuhiro Ikeda, Hiroyuki Miyoshi, Norimichi Koitabashi, Atai Watanabe, Masahiko Kurabayashi
Journal: Circulation (2006)

Introduction Reduced expression of SERCA2 gene impairs calcium handling and contributes to contractile dysfunction of the heart. Unlike adenovirus- or adenoassociated vectors, lentivirus can stably...
Structural and Functional Studies Of The Intrinsically Disordered Protein AF9 In MLL-AF9 Leukemia
Authors: Aravinda Kuntimaddi, Alyson Lokken, Shubin Zhang, Jeremy Thorpe, Benjamin Leach, Bhavna Lumba, Charles S. Hemenway, Mazhar Adli, Nancy J. Zeleznik-Le, John H. Bushweller
Journal: Blood (2013)
Jefferson Medical College.
Authors: Samuel McClellen
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 15606: Left Ventricle Function and Sympathetic Innervation in Type 1 Diabetes
Authors: Scott Swanson, David Raffel, Gisela Mueller, Claire Duvernoy, Cynthia Plunkett, Martin Stevens, Rodica Pop-Busui
Journal: Circulation (2011)

Objective: In type 1 diabetes (T1DM) alterations in left ventricle (LV) function may occur without clinical evidence of other complications, possibly due to sympathetic activation and/or alteration...
The Pathogenesis of the Secondary Disease After Foreign Bone Marrow Transplantation in X-Irradiated Mice&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: D.W. van Bekkum, O. Vos, W.W.H. Weyzen
Journal: JNCI Journal of the National Cancer Institute (1959)

The available information on the pathogenesis of the secondary disease after foreign bone marrow transplantation in irradiated mice is reviewed. Additional experiments are reported. The incidence of secondary disease after foreign bone marrow transplantation in mice was studied in various host-donor combinations after irradiation at three dosage levels. A characteristic secondary mortality was observed in CBA mice that received isologous bone marrow after the larger doses of X rays. Secondary mortality did not occur in F1 hybrid mice that received isologous bone marrow, but severe diarrhea developed after the higher doses of X rays when followed by treatment with parental-strain bone marrow. In mice treated with rat bone marrow the development and persistance of symptoms of secondary disease was correlated with the presence of a functional rat bone marrow. Skin lesions and wasting, typical of secondary disease, as well as a high rate of mortality were observed in F1 mice after the establishment of a parabiotic junction with a parental strain mouse of the same sex and age. Evidence has been provided in support of the hypothesis that the secondary disease in mice treated with foreign bone marrow is due to the combined effects of late radiation damage, an immunological reaction of the graft against the host, and an impaired immunological defense against microorganisms.
Abstract 1936: Cornell Product Left Ventricular Hypertrophy In Electrocardiogram Is A Strong Predictor Of Stroke In Community-dwelling Japanese Normotensives
Authors: Joji Ishikawa, Shizukiyo Ishikawa, Kazunori Kayaba, Kazuyuki Shimada, Kazuomi Kario
Journal: Circulation (2007)

Background : Incidence of stroke is higher than ischemic heart disease in Japanese. Left ventricular hypertrophy (LVH) is associated with an increased risk for stroke among hypertensives. We evaluated the risk of LVH among normotensives (SBP/DBP&lt;120/80 mmHg) subjects. Methods: In a Japanese general population, 10755 subjects who were undertaken electrocardiogram and measured BP at baseline were evaluated Cornell product (CP) and Sokolow-Lyon (SL) voltage as markers of LVH (CP≥2440 mm ms and SL voltage&gt;35 mm). Follow-up was performed for 10 years and incidence of stroke was evaluated. Results: Prevalence of CP-LVH were 2.7% for normotensives, 5.2 % for prehypertensives, 11.0 % for hypertensives, and that of SL-LVH were 8.6%, 11.4%, and 22.5%, respectively. In overall subjects, CP-LVH and SL-LVH were independent predictors of stroke [CP-LVH: hazard risk (HR) 1.65, 95% confidence interval (CI) 1.22–2.25, SL-LVH: HR 1.30, 95%CI 1.02–1.65] after adjustment for confounding factors. In Cox regression analysis in each stage of hypertension, hazard ratios of stroke in subjects with CP-LVH were higher among normotensives (HR 8.28, 95%CI 3.72–18.41) than among prehypertensives (HR 1.56, 95%CI 0.67–3.63) and hypertensives (HR 1.48, 95%CI 1.02–2.13) (Figure ), although that in subjects with SL-LVH were not significant (normotensives: HR 1.54, 95%CI 0.70–3.40, prehypertensives: HR 1.29, 95%CI 0.72–2.32, hypertensives: HR 1.21, 95%CI 0.90–1.62). Conclusion: The ECG-LVH independently predicted future stroke in a Japanese general population. The specificity of the Cornell product-LVH is higher than that of Sokolow-Lyon-LVH especially among normotensive subjects &lt;120/80 mmHg.
Abstract 4409: Phenotypic Plasticity of LMNA Mutations in Cardiovascular System Includes Isolated Cardiac Progeria, Dilated and Hypertrophic Cardiomyopathies, Atrial Fibrillation, Conduction Defects and Degenerative Valvular Diseases
Authors: Gabriela Rodriguez, Grazyna Czernuszewicz, Yanli Tan, Neal Kleiman, Guillermo Torre-Amione, James T Willerson, Simon Sims, Ali J Marian
Journal: Circulation (2008)
Abstract 2843: Evaluation of Early Myocardium Damage in Patients with Chagas' Disease with Diastolic Function Analysis and Doppler Tissue Imaging
Authors: A Garcia-Alvarez, M Sitges, MJ Pinazo, S Poyatos, B Vidal, E Posada, JT Ortiz, M Heras, M Azqueta, J Gascon, G Sanz
Journal: Circulation (2008)

Chagas’ disease represents one of the main causes of mortality in Latin America and is becoming a relevant public health problem in EEUU and Europe because of the migratory movements. About one third of Chagas infected people develop a severe and potentially lethal cardiac dysfunction. Early identification of myocardium damage in asymptomatic patients (undetermined phase) would be very important for risk stratification and treatment. Our aim was to establish the usefulness of diastolic function measurement and the implementation of Doppler tissue imaging (DTI) techniques to identify patients with early myocardium damage. Thirty-one patients were studied; including 21 recent diagnosed asymptomatic chagasic patients and 10 non infected control individuals. All patients were assessed with a conventional 2D-echocardiography with diastolic function analysis and images acquisition for applying DTI. Comparisons of continuous variables between two groups were performed by T-test analysis or the Mann-Whitney U test according to normality. Conventional 2D-echocardiogram showed normality of left ventricular (LV) dimensions and LV ejection fraction for all 31 patients, without differences between both groups. However, chagasic patients presented a statistically significant lengthening of the deceleration time of early diastolic filling (DT), a higher left atrium volume (LAV) and a reduced early diastolic mitral annular velocity (Em) comparing to controls individuals. When evaluating the systolic velocity of longitudinal contractility, DTI showed a trend to lower systolic velocity at inferior and anterior walls (table). In patients with Chagas’ disease who are in the undetermined phase, LA volumes and diastolic dysfunction allowed to identify early cardiac abnormalities. Doppler tissue imaging might also be a potentially useful tool for detecting incipient myocardial alteration in this context.
Abstract 1930: The ARVD/C Variome of the Netherlands
Authors: Jan D Jongbloed, Zahir A Bhuyian, Paul A van der Zwaag, Ludolf G Boven, Jasper J van der Smagt, Monique G Cox, Ans C Wiesfeld, Luz M Rodriquez, Roselie Jongbloed, Isabelle C van Gelder, Maarten P van den Berg, Richard J Sinke, Robert M Hofstra, Richard N Hauer, Arthur A Wilde, Peter J van Tintelen
Journal: Circulation (2009)
Abstract 860: Phenotypic Characterization Of Murine And Human Cardiac-resident Progenitor Cells Isolated On Basis Of Aldehyde-dehydrogenase Activity
Authors: Albert Spicher, Andrea Meinhardt, Marc-Estienne Roehrich, Giuseppe Vassalli
Journal: Circulation (2007)

Identification of stem cells based on hematopoietic stem cell (HSC) surface markers, such as stem cell antigen-1 (Sca-1) and the c-kit receptor, has limited specificity. High aldehyde-dehydrogenase (ALDH) activity is a general cellular property of stem cells shared by HSC, neural, and intestinal stem cells. The presence of cells with high ALDH activity in the adult heart has not been investigated. Methods: Cells were isolated from adult mouse hearts, and from atrial appendage samples from humans with ischemic or valvular heart disease. Myocyte-depleted mouse Sca-1+, and lineage (Lin)-negative/c-kit+ human heart cells were purified with immunomagnetic beads. ALDH-high cells were identified using a specific fluorescent substrate, and sorted by FACS. Cell surface marker analysis was performed by flow cytometry. Results: Myocyte-depleted mouse heart cells contained 4.8+/−3.2% ALDH-high/SSC-low and 32.6+/−1.6% Sca-1+ cells. ALDH-high cells were Lin-negative, Sca-1+ CD34+ CD105+ CD106+, contained small CD44+ (27%) and CD45+ (15%) subpopulations, and were essentially negative for c-kit (2%), CD29, CD31, CD133 and Flk-1. After several passages in culture, ~20% of ALDH-high cells remained ALDH-high. Myocyte-depleted human atrial cells contained variable numbers of ALDH-high cells ranging from 0.5% to 11%, and 4% Lin-negative/c-kit+ cells. ALDH-high cells were CD29+ CD105+, contained a small c-kit+ subpopulation (5%), and were negative for CD31, CD45 and CD133. After 5 passages in culture, the majority of ALDH-high cells remained ALDH-high. Conclusions: Adult mouse and human hearts contain significant numbers of cells with high ALDH activity, a general cellular property that stem cells possess in different organs, and express stem cell markers (Sca-1 and CD34 in the mouse). The immunophenotype of cardiac-resident ALDH-high cells differs from that previously described for bone marrow ALDH-high HSC, and suggests that this cell population may be enriched in mesenchymal progenitors. Analysis of lineage differentiation potential of ALDH-high cells is in progress. ALDH activity provides a new, practical approach to purifying cardiac-resident progenitor cells.
Reduced morbidity after gradual discontinuation of lithium treatment for bipolar I and II disorders: a replication study
Authors: R J Baldessarini, L Tondo, G Floris, N Rudas
Journal: American Journal of Psychiatry (1997)

The aim of this study was to verify reduction of early affective morbidity by gradual, rather than rapid, discontinuation of lithium treatment.For 78 patients with bipolar disorders, lithium treatment was discontinued either rapidly (over 1-14 days) or gradually (over 15-30 days). The effects of the two schedules were compared by survival analysis of time to first recurrence.Median time to recurrence was 5.6 times as long for gradual discontinuation (14.0 months) as for rapid discontinuation (2.5 months). The ratios of the median survival times for gradual and rapid discontinuation were similar in I and II subtypes and in depression and mania (4-6:1). The polarities of the episodes at onset and at first recurrence after lithium discontinuation were 83.6% concordant.These results independently confirm a reduction in morbid risk from slow discontinuation of lithium treatment for bipolar disorders.
Abstract 3665: Changing Age Distribution of First Ever Acute Myocardial Infarction Among Men and Women in New Jersey Hospitals
Authors: Alan C Wilson, Yu-Hsuan Shao, Nora M Cosgrove, John S Pantazopolous, Abel E Moreyra, John B Kostis
Journal: Circulation (2007)

While the death rate from coronary heart disease has fallen, the occurrence of non-fatal acute myocardial infarction (AMI) has risen, especially among the elderly.   Methods:  To study the shift in age distribution of first-ever hospitalized (index) AMI we used two four-year periods, 1986–1989 and 2001–2004 from the New Jersey statewide myocardial infarction data acquisition system, MIDAS. The frequency and age-specific rates were compared for men and women.   Results:  There were 60,226 index AMI cases in the 1986–1989 period and 58,901 in 2001–2004. The age distribution curve show a marked shift towards older ages, with a noticeable drop in occurrence among those aged 55 to 70. The median age at which the index AMI occurred rose significantly (p   Conclusions:  The annual occurrence of index AMI has remained stable over the past fifteen years, while the first AMI event has been postponed by 2 and 5 years among men and women respectively. Before age 85 both the number and rate of first AMI events decreased, mostly among men. In contrast among the oldest the increase in events was seen more in women. Among persons younger than 60, however, there appears to have been little change in age at first AMI.
Abstract 5099: Extent and Severity of Coronary Stenosis at Autopsy Varies by Sex in Fatal Cases of Coronary Heart Disease
Authors: Nathaniel Smilowitz, Judith S Hochman, Barbara A Sampson, Sandeep Mangalmurti, Jonathan Siegfried, Harmony R Reynolds
Journal: Circulation (2009)

Background: Recently, the decline in mortality from coronary heart disease (CHD) has slowed in younger age groups, particularly young women. Young women with acute coronary syndromes (ACS) less often have obstructive CHD at angiography. This could reflect pre-hospital death of women with the most severe disease. Hypothesis: There is a sex difference in extent and severity of coronary stenosis on post-mortem evaluation of people who died of CHD. Methods: Reports of NYC medical examiner autopsies conducted on women 21–54 from1/1/06 –12/31/07 were reviewed if CHD was a cause of death (COD) and cocaine toxicology was negative. Women with CHD as immediate COD were matched by age and race to males with CHD as immediate COD. We analyzed severity of coronary stenosis based on the standard definition of “significant” CHD: ≥75% cross sectional area [CSA] stenosis in a major epicardial vessel, corresponding to 50% angiographic diameter stenosis, or ≥50% CSA stenosis in the left main. We assigned coronary jeopardy scores based on the number of obstructed segments. Statistical analysis was conducted by t-test and chi-square. Results: Among 112 women with CHD as the immediate or contributing COD, 24 had immediate COD that were not obviously related to CHD (pneumonia, intoxication, etc). 84 cases with CHD as immediate COD were matched to men. Women were less likely to have “significant” coronary stenosis than men (68% vs. 87%, p=0.006). Among decedents with single-vessel CHD, the RCA was affected more often in women and the LAD in men. Jeopardy scores were lower in women but there was no sex difference in frequency of gross myocardial findings consistent with scarring (21% vs. 32% of men, p=0.16). Conclusion: Young women determined at autopsy to have died of CHD exhibit significantly less extensive and severe coronary stenosis than men. These findings are consistent with angiographic findings in women with ACS. Mechanisms of death in these cases are unknown and may include spasm or arrhythmia.
Abstract 8748: D-dimer Levels in Combination with Clinical Risk Factors can Effectively Predict Subsequent Thromboembolic Events in Patients with Atrial Fibrillation during Oral Anticoagulation Therapy
Authors: Tsuneaki Sadanaga, Shun Kohsaka, Satoshi Ogawa
Journal: Circulation (2010)

Introduction: The aim of the study was to assess whether elevated D-dimer levels in combination with clinical risk factors can predict subsequent thromboembolic events in patients with atrial fibri...
Abstract 18402: Impact of the Use of Different Bleeding Scales on the Rate of 6-Month Bleeding After PCI: Results from the PARIS Registry
Authors: Georgios Vlachojannis, Giora Weisz, Bernhard Witzenbichler, Timothy D Henry, Annapoorna S Kini, Thomas Stuckey, David J Cohen, Peter B Berger, Antonio Colombo, Ioannis Iakovou, Philippe Gabriel Steg, David J Moliterno, David Atoniucci, Ron Waksman, Mitchell Krucoff, Raj Vadde, Elliot Elias, Jennifer Yu, Leila Khalili, Samantha Sartori, Usman Baber, Roxana Mehran
Journal: Circulation (2012)

Background: Multiple definitions have been used to classify bleeding, which is an important safety metric in cardiovascular clinical studies. We investigated the impact of different scales on apparent 6-month bleeding rates in a real-world registry of patients on dual antiplatelet therapy following percutaneous coronary intervention (PCI). Methods: PARIS is an ongoing multicenter, multinational, observational study of 5033 patients examining the modes and clinical correlates of medication non-adherence. All bleeding events were independently adjudicated according to the TIMI (Thrombolysis in Myocardial Infarction), BARC (Bleeding Academic Research Consortium) and ACUITY Acute Catheterization and Urgent Intervention Triage Strategy) bleeding classification schemes. In this analysis, we compared the bleeding rates using these bleeding scales. BARC &lt;3 bleeding was considered minor; BARC ≥3 bleeding was considered major. Results: The overall incidence of minor and major bleeding at 6 months using the ACUITY classification scheme was 4.71% (n=237).; overall bleeding rates defined by the TIMI, and BARC scales were 1.21% and 4.67%, respectively (Figure). Rates of minor bleeding were 0.5%, 3.28%, and 3.18% using the TMI, BARC and ACUITY definitions; rates of major bleeding were 0.74%, 1.49% and 1.65%, respectively. Agreement between the ACUITY and BARC definitions yielded a high level of correlation (kappa 0.86, p&lt; 0.001). TIMI bleeding, rates were excluded from this analysis do the low number of TIMI bleeds. Conclusions: In this real-world contemporary PCI registry, the overall incidence of any, major and minor bleeding at 6 months varied substantially between different classification schemes. These findings highlight the importance of bleeding definition selection and emphasize the problem of cross trial comparison when different definitions of bleeding are used.