tbuckley/cabot-search huggingface dataset:
The absence of H-2 antigens from mouse pancreatic beta-cells demonstrated by immunoferritin labeling.
Authors: E L Parr
Journal: The Journal of Experimental Medicine (1979)

Islets of Langerhans were isolated from mouse pancreases and fixed in periodatelysine-paraformaldehyde. The fixed islets were then dissociated with trypsin and EDTA to yield cell suspensions that contained mainly four cell types; beta-cells, capillary endothelial cells, acinar cells, and pancreatic duct epithelial cells. The nonislet cells were probably associated wtih the surface of the isolated islets. The H-2 antigens of the dissociated pancreatic cells were labeled with an immunoferritin technique. Pancreatic duct epithelial cells showed specific ferritin labeling on their lateral cell membranes but not on apical microvillus membranes. Acinar cells were also labeled on lateral membranes, and the capillary endothelial cells were labeled on both the luminal and albuminal aspects of their surface membranes. In contrast, pancreatic beta-cells were unlabeled. The number of ferritin molecules per unit length of beta-cell membrane was essentially the same on cells from the antigenic strain and the congeneic control strain, and was about 200-fold less than on the labeled pancreatic duct epithelial cell lateral membranes. Pancreatic beta-cells are therefore one of six known epithelial cell types on which H-2 antigens can not be detected by immunoferritin labeling. The apparent absence of H-2 antigens from these cells suggests a study of the viability of beta-cells in allografts of dissociated islet cells, in which the beta-cell would not be in contact with antigenic cells. Such studies might lead to a new approach to the control of diabetes mellitus by transplantation.
Mismatch between Radionuclide and Contrast Angiography in the Assessment of the Perfusion of a Transplanted Kidney
Authors: T HERRMANN, D GRANJON, M DECOUSUS, C SOLER, P RUSH
Journal: Clinical Nuclear Medicine (1991)

When early complications occur after a kidney transplant, radionuclide angiography may be useful in determining a possible vascular origin. The authors describe the case of a patient with anuria continuing 24 hours after transplantation. Radionuclide angiography showed a defect at the site of the renal graft, suggestive of arterial or venous thrombosis. Contrast angiography was performed immediately but showed no vascular abnormality; neither did radionuclide angiography performed the next day. The authors concluded that a spasm at the site of the renal artery anastomosis, overcome by contrast angiography, could explain this phenomenon.
Dissecting Aneurysm of the Aorta The Clinical Features of Thirty Autopsied Cases
Authors: BLAIR D. ERB, I. FRANK TULLIS
Journal: Circulation (1960)

The clinical diagnosis of dissecting aneurysm of the aorta depends on awareness of the entity, keen clinical suspicion, and an understanding of the varied manifestations. Clinical suspicion is sharpened by association of certain preexisting conditions found to be related to an increased incidence of aortic dissection. Recognition of the Marfan's syndrome, pregnancy, or preexisting hypertension in a patient presenting as an acute catastrophe may lead to the diagnosis. A family history of aortic dissection is similarly helpful. The variable manifestations call for careful reasoning. Multiple system involvement in many cases is the initial lead in establishing the diagnosis. The many systems frequently involved in the symptomatology of aortic dissection have in common the origin of the blood supply. When the aorta is damaged, branches to various organs may be affected so that the symptoms depend on the branches involved. Because any portion of the aorta may be involved in the dissecting process, no single clinical picture suffices for its recognition. Aortic valvular findings often are seen with involvement of the ascending aorta, central neurologic findings may result from occlusion of the carotid arteries, spinal cord manifestations may result from occlusion of the intercostal arteries, renal manifestations may be seen with renal artery involvement, and so on down the aorta. However, the pattern of a catastrophic episode—whether cardiovascular, neurologic, or abdominal—calls for consideration of aortic dissection. All of the finesse of the most careful physical examination may be required to make the diagnosis but the coexistence of chest pain, aortic murmurs, and peripheral artery occlusion is practically diagnostic. Laboratory adjuncts including roentgenographic evidence of mediastinal widening, evidence of hematuria, and the absence of electrocardiographic evidence of myocardial infarction may be helpful. Electrocardiographic evidence suggestive of myocardial infarction does not, however, exclude aortic dissection. Dissecting aneurysm of the aorta now is a surgical emergency that requires early accurate diagnosis and early surgical treatment, if the natural survival rate of 10 per cent is to be improved.
GENETIC POLYMORPHISMS OF ANGIOTENSIN II TYPE 1 RECEPTOR AND THE DEGREE OF LEFT ATRIAL REMODELING IN PATIENTS WITH NON-VALVULAR ATRIAL FIBRILLATION
Authors: Sook Kyoung Kim, Boyoung Joung, Dong Jik Shin, Jae Hyung Park, Jeung Min Kim, Moon Hyung Lee, Yang Soo Jang, Hui-Nam Pak
Journal: Journal of the American College of Cardiology (2011)
The Editor, 'The British Journal of Dermatology'. Scrotal dermatitis due to hexachlorophene baths.
Authors: Harvey Baker, Mary J. Lloyd
Journal: British Journal of Dermatology (1967)

Journal Article The Editor, ‘The British Journal of Dermatology’. Scrotal dermatitis due to hexachlorophene baths. Get access Harvey Baker, Harvey Baker St. John's Hospital for Diseases of the Skin, Homerton Grove, London, E.9 Search for other works by this author on: Oxford Academic Google Scholar Mary J. Lloyd Mary J. Lloyd St. John's Hospital for Diseases of the Skin, Homerton Grove, London, E.9 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 79, Issue 12, 1 December 1967, Pages 727–728, https://doi.org/10.1111/j.1365-2133.1967.tb11453.x Published: 01 December 1967
Role of intracellular calcium ([Ca2+]i ) and tyrosine phosphorylation in adhesion of cultured vascular smooth muscle cells to fibrinogen
Authors: L Xie
Journal: Cardiovascular Research (1998)

Objective: Fibrinogen is an independent risk factor for cardiovascular disease. This study has investigated the role of intracellular Ca2+ ([Ca2+]i) and tyrosine phosphorylation in the attachment of human and rat-derived cultured vascular smooth muscle cells to fibrinogen. Methods: Cells were cultured from human saphenous vein segments (HVSMC) and from an established rat aortic cell line (A7r5). [Ca2+]i was measured using fura-2 and adhesion was studied using pre-coated 96 well polystyrene plates. Results: Fibrinogen increased [Ca2+]i in both cell types. In A7r5 cells fibrinogen-induced increases in [Ca2+]i were partially inhibited by a peptide containing the amino acid sequence Arg-Gly-Asp (RGD) which interferes with binding to integrins. In contrast RGD increased [Ca2+]i in HVSMC, but did not inhibit responses to fibrinogen. Ni2+, an inorganic calcium channel blocker largely abolished the rise in [Ca2+]i, but blockers of voltage-operated calcium channels failed to affect [Ca2+]i responses to fibrinogen in either cell type. Genistein, an inhibitor of tyrosine kinase inhibited fibrinogen-induced rises in [Ca2+]I, while daidzein, an inactive analogue, was without effect. Adhesion of cells to fibrinogen was concentration- and time-dependent. Cell adhesion to fibrinogen was partially inhibited by RGD peptide in both cell types. Adhesion of cell to fibrinogen was inhibited by chelation of [Ca2+]i with BAPTA-AM, inhibition of Ca2+ entry by Ni2+, and inhibition of tyrosine kinases by genistein, but heparin had no effect on adhesion. Conclusions: Vascular smooth muscle cells attach to fibrinogen in part through RGD-type interactions. Activation of tyrosine kinase(s) and a subsequent rise in [Ca2+]i appear to be important signals mediating the response to fibrinogen.
Use of Exhaled Nitric Oxide Measurements to Guide Treatment in Chronic Asthma
Authors: Andrew D. Smith, Jan O. Cowan, Karen P. Brassett, G. Peter Herbison, D. Robin Taylor
Journal: New England Journal of Medicine (2005)

International guidelines for the treatment of asthma recommend adjusting the dose of inhaled corticosteroids on the basis of symptoms, bronchodilator requirements, and the results of pulmonary-function tests. Measurements of the fraction of exhaled nitric oxide (FE(NO)) constitute a noninvasive marker that may be a useful alternative for the adjustment of inhaled-corticosteroid treatment.In a single-blind, placebo-controlled trial, we randomly assigned 97 patients with asthma who had been regularly receiving treatment with inhaled corticosteroids to have their corticosteroid dose adjusted, in a stepwise fashion, on the basis of either FE(NO) measurements or an algorithm based on conventional guidelines. After the optimal dose was determined (phase 1), patients were followed up for 12 months (phase 2). The primary outcome was the frequency of exacerbations of asthma; the secondary outcome was the mean daily dose of inhaled corticosteroid.Forty-six patients in the FE(NO) group and 48 in the group whose asthma was treated according to conventional guidelines (the control group) completed the study. The final mean daily doses of fluticasone, the inhaled corticosteroid that was used, were 370 microg per day for the FE(NO) group (95 percent confidence interval, 263 to 477) and 641 microg per day for the control group (95 percent confidence interval, 526 to 756; P=0.003), a difference of 270 microg per day (95 percent confidence interval, 112 to 430). The rates of exacerbation were 0.49 episode per patient per year in the FE(NO) group (95 percent confidence interval, 0.20 to 0.78) and 0.90 in the control group (95 percent confidence interval, 0.31 to 1.49), representing a nonsignificant reduction of 45.6 percent (95 percent confidence interval for mean difference, -78.6 percent to 54.5 percent) in the FE(NO) group. There were no significant differences in other markers of asthma control, use of oral prednisone, pulmonary function, or levels of airway inflammation (sputum eosinophils).With the use of FE(NO) measurements, maintenance doses of inhaled corticosteroids may be significantly reduced without compromising asthma control.
Chloroprocaine and Pseudocholinesterase Deficiency
Authors: Mary Wheeler
Journal: JAMA (1975)

<h3>To the Editor.—</h3> The recent article by Freeman and Arnold (231:56,1975) suggests that chloroprocaine may be safer for paracervical block because it is rapidly degraded by fetal plasma cholinesterase. A potential hazard arises in the case of an infant with inherited pseudocholinesterase deficiency. Since this condition is inherited as an autosomal recessive trait, the parents might not have shown previous sensitivity to local anesthetics or succinylcholine but will have impaired ability to degrade these drugs. Therefore, the dose to the fetus will be increased because of sustained high levels in the mother's circulation. Although rare, this disorder should be kept in mind by physicians using these drugs.
Echo phonology: Signs of a link between gesture and speech
Authors: Bencie Woll, Jechil S. Sieratzki
Journal: Behavioral and Brain Sciences (1998)

This commentary supports MacNeilage's dismissal of an evolutionary development from sign language to spoken language but presents evidence of a feature in sign language (echo phonology) that links iconic signs to abstract vocal syllables. These data provide an insight into possible mechanism by which iconic manual gestures accompanied by vocalisation could have provided a route for the evolution of spoken language with its characteristically arbitrary form–meaning relationship.
Update on FDA Regulation of In Vitro Diagnostic Devices
Authors: Steven Gutman
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The common cold: Current therapy and natural history
Authors: S SPECTOR
Journal: Journal of Allergy and Clinical Immunology (1995)

Despite its prevalence, the common cold is complicated and can be difficult to treat, even symptomatically. There is still no cure for the myriad of viruses that cause the common cold. Many of the most popular remedies are either ineffective or counterproductive. This paper reviews the causes and course of upper respiratory infections, and discusses treatment options, including a new anticholinergic aqueous formulation for controlling rhinorrhea. (J ALLERGY CLIN IMMUNOL 1995;95:1133-8.)
Potential psychological benefits from early treatment of port-wine stains in children
Authors: None Troilius, None WrangsjO, None Ljunggren
Journal: British Journal of Dermatology (1998)

Journal Article Potential psychological benefits from early treatment of port‐wine stains in children Get access A. Troilius, A. Troilius Department of Dermatology, University Hospital, 205 02 Malmö, Sweden, Search for other works by this author on: Oxford Academic Google Scholar B. WrangsjÖ, B. WrangsjÖ Institute of Training in Child and Adolescent Psychiatry, Finsenhuset, St Göran's Hospital, 112 81 Stockholm, Sweden Search for other works by this author on: Oxford Academic Google Scholar B. Ljunggren B. Ljunggren Department of Dermatology, University Hospital, 205 02 Malmö, Sweden, Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 139, Issue 1, 1 July 1998, Pages 59–65, https://doi.org/10.1046/j.1365-2133.1998.02314.x Published: 01 July 1998
HELP Network Says Firearms Data Gap Makes Reducing Gun Injuries More Difficult
Authors: Charles Marwick
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Direct Measurement of Human Immunodeficiency Virus Seroconversions in a Serially Tested Population of Young Adults in the United States Army, October 1985 to October 1987
Authors: John G. McNeil, John F. Brundage, Z. Frank Wann, Donald S. Burke, Richard N. Miller
Journal: New England Journal of Medicine (1989)

Direct measurement of the incidence of infection with the human immunodeficiency virus (HIV)--the rate of new HIV infection--is vital if we are to understand better the dynamics of the current epidemic of HIV infection. Because soldiers are periodically and routinely screened for antibody to HIV, it is possible to measure the incidence of HIV infection directly in this large, demographically well-characterized population of young adults. To determine the incidence of HIV infection in this population, we examined test results reported by the U.S. Army's routine antibody-screening programs. During the first two years of the screening programs, the observed incidence of HIV infection was approximately 0.77 per 1000 persons per year. This rate was higher than expected on the basis of previously published estimates of seroprevalence in the Army (approximately 1.50 per 1000). On the basis of this annual incidence, and assuming it to be stable, we estimate that approximately 600 soldiers will become infected with HIV each year. The observed rate in the Army may be lower than the incidence of HIV infection in the corresponding demographic groups within the general U.S. population.
Morphine Prophylaxis of Paralytic Ileus
Authors: J. T. Chesterman, W. J. Sheehan
Journal: BMJ (1945)

MEDICAL JOIRNAL ache and nausea, so, although apyrexial, 0.6 g. of sulphostab was given intravenously on 13/9/42.Had no recurrence of pyrexia, and was discharged fit on 19/9/42.Clinical features : Sulphostab was withheld, as it was hoped he would develop pyrexia.However, temperature did not surpass 99.6' at this time, but patient looked ill and complained of headache and nausea.Eventually, after having sulphostab, his general condition and appetite improved and head- aches disappeared; he was discharged fit six days later.Eye examination on 18/9/42: Edges of both disks hazy; disks slightly swollen about 2D.No haemorrhage in retina, but not good colour.Conclusion: Bilateral papillitis.Laboratory findings :-Thick blood films, 10/8/42, no spironema seen; 12/8/42, spironema seen.Cerebrospinal fluid, 7/9/42: Clear-not under pressure; cells less than 5 per c.mm.; protein not increased; chlorides (as NaCI), 700 mg. per 100 c.cm. Venous blood, 12/8/42: Kahn-negative.Urine, 12/8/42: Much urobilin present-much urobilinogen.Case 9.-Unit D; has worked in vicinity of Caves A and D. Slept in the open on several occasions while on maneuvres.No history of being bitten while sleeping in open.Admitted to hospital 10/8/42; temperature normal.No lice in clothing and no marks of insect-bites on body.Temperature rose to 102' on day of admission.Spironema seen in thick blood film; 0.6 g. of sulphostab given intravenously while pyrexial.Next evening the temperature was normal and remained normal until 19/8/42, when it suddenly rose to 102.4'.Thick blood film: No spironema seen; 0.6 g. of sulphostab given intravenously while pyrexial.Temperature normal next day and until 10/9/42, when he was discharged fit for duty.Clinical findings :-Pain in lumbar region, attacks of dizziness.Aching behind eyes and unable to focus clearly on print even when apyrexial.Eye examination on 5/10/42: Slight papillitis left disk.Laboratory findings :-Thick blood films, 10/8/42, spironema seen; 19/8/42, no spironema seen.Cerebrospinal fluid not examined.Venous blood, 10/8/42: Kahn-negative.Urine, 10/8/42: no urobilin.Case 10.-Unit E; dug trench near Cave E. Admitted to hospital 10/8/42 complaining of headache and shivering.Temperature 103.8'.No lice on clothing or evidence of insect-bites on body.Spironema founc in thick blood film on 10/8/42; 0.6 g. of sulpho- * This appears to be a general occurrence in relapsing fever, and is being described elsewhere.
Blood eosinophils and serum IgE as predictors for prognosis of interferongamma therapy in atopic dermatitis
Authors: G.W. Noh, K.Y. Lee
Journal: Allergy (1998)

Background Interferon‐gamma (IFN‐γ) therapy has been reported to be effective in atopic dermatitis. However, IFN‐γ therapy in atopic dermatitis has not yet been well established, ln this study, immunologic variables were evaluated as predictors for the prognosis of IFN‐γ therapy in atopic dermatitis Methods Sixty‐eight atopic dermatitis patients were each treated 18 times with 2 X 10 6 units/m 2 IFN‐γ. Blood IgE level, eosinophil percentage, eosinophil count, and levels of IFN‐γ, interIeukin‐4 (IL‐4), IL‐5, and IL‐10 were investigated. According to clinical responses, patients were classified into three groups: patients with improved clinical severity scores of over 20% were included in group A; those with improved scores of 20% or less in group B; and those with no improvement in group C. Results Serum IgE levels and blood eosinophil percentages were the lowest n group A. Most atopic dermatitis patients with an eosinophil percentage over 9% and IgE level over 1500 lU/ml did not respond to IFN‐γ therapy. Initial IL‐10 levels were the highest in group A. IL‐4 levels in group A, and IL‐5 and IL‐10 levels in all groups were significantly decreased by IFN‐γ therapy. Conciusions WN‐y therapy may be recommended for atopic dermatitis patients with blood eosinophil percentages less than 9% and serum IgE levels less than 1500 lU/ml.
Multicentric Meningioma Evaluation With Tc-99m MIBI SPECT, CT, and MRI
Authors: FERNANDO CESANI, RANDY ERNST, GAYLE STOREY, JAVIER VILLANUEVA-MEYER
Journal: Clinical Nuclear Medicine (1995)

Meningiomas comprise 15% of adult intracranial tumors. They are often found in middle-aged adults and are more likely to occur in women. They are frequently located in the lateral hemisphere convexity, the parasagittal region, and the falx cerebri. They originate from meningoendothelial cells within the arachnoid villi, but may arise from other meningeal constituents, such as fibroblasts and blood vessels. Multicentric meningiomas present at an earlier age, often associated with neurofibromatosis type 2. The authors report a case of a woman with multicentric meningiomas which were identified with Tc-99m MIBI SPECT, MRI, and CT. Tc-99m MIBI uptake is related to 1) tissue perfusion, and 2) normal cell membrane and mitochondrial activity. In malignant tumors the uptake of Tc-99m MIBI also has been associated with the presence of P-glycoprotein in the cell membrane which is related to the multidrug resistant gene. The uptake of Tc-99m MIBI is not limited to malignant brain tumors, but also can be seen in benign and hypervascular meningiomas, as illustrated in this patient.
A PSYCHIATRIC STUDY OF PATIENTS MANIFESTING DYSTROPHIA MYOTONICA
Authors: EDWARD G. BILLINGS, ABE RAVIN
Journal: American Journal of Psychiatry (1941)

1. Nine affected and two unaffected members of five families in which dystrophia myotonica has occurred were studied psychiatrically in conjunction with other detailed clinical and research investigations at the University of Colorado School of Medicine. 2. The literature dealing with the personality reactions associated with the disorder is reviewed, and 3. The results of the study, which included a history of personality development and activity, mental status, physical and neurological examinations, intelligence testing, tests for thinking disabilities and the Rorschach experiment, are reported and an attempt at interpreting them is made.
An innovative, safe and sterile sigmoid access (ISSA) for NOTES
Authors: D. Wilhelm, A. Meining, S. Delius, A. Fiolka, S. Can, C. Hann von Weyhern, A. Schneider, H. Feussner
Journal: Endoscopy (2007)

See also: Commentaire de travail de D. Wilhelm et al., pp. 401Endoscopy 2007; 39(05): 483-483DOI: 10.1055/s-0032-1306962