ALDOSTERONE: OBSERVATIONS ON THE REGULATION OF SODIUM AND POTASSIUM BALANCE
Authors: J A LUETSCHER, R H CURTIS
Journal: Annals of Internal Medicine (1955)

Article1 October 1955ALDOSTERONE: OBSERVATIONS ON THE REGULATION OF SODIUM AND POTASSIUM BALANCEJOHN A. LUETSCHER JR., ROBERT H. CURTISJOHN A. LUETSCHER JR., ROBERT H. CURTISAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-43-4-658 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAccumulation of edema and serous effusions occurs in different clinical patterns, depending on the basic pathology. Changes in capillary pressure or colloid osmotic pressure lead to increase of interstitial fluid at the expense of plasma volume. This process alone would lead to vascular collapse rather than to edema. Retention of ingested sodium and water provides the bulk of edema and may be a useful compensation against falling plasma volume. Sodium retention may be associated with impaired renal blood flow or glomerular filtration, but in most patients the renal tubule appears to exert final control of sodium excretion. The work presented...Bibliography1. DemingLuetscher QBJA: Bioassay of desoxycorticosterone-like material in urine, Proc. Soc. Exper. Biol. and Med. 73: 171, 1950. CrossrefGoogle Scholar2. LuetscherDemingJohnson JAQBBB: The sodium-retaining activity of the corticoid fraction of urine of oedematous patients, Ciba Foundation Colloquia on Endocrinology, Vol. IV, G. E. W. Wolstenholme, Editor, 1952, J. and A. Churchill, London, p. 530. Google Scholar3. TaitSimpsonGrundy JFSAHM: The effect of adrenal extract on mineral metabolism, Lancet 1: 122, 1952. CrossrefMedlineGoogle Scholar4. SimpsonTaitWettsteinNeherv. EuwSchindlerReichstein SAJFARJOT: Die Konstitution des Aldosterons, Helv. chim. Acta 37: 1163, 1954. CrossrefGoogle Scholar5. 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Google Scholar23. SingerStack-Dunne BMP: Secretion of aldosterone and corticosterone by the rat adrenal, Nature, London 174: 790, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Presented at the Thirty-sixth Annual Session of The American College of Physicians, Philadelphia, Pennsylvania, April 25, 1955.From the Department of Medicine, Stanford University School of Medicine, San Francisco, California.†This work was supported by a research grant (A-630) from the National Institute of Arthritis and Metabolic Diseases, Public Health Service.‡Trainee of the National Institute of Arthritis and Metabolic Diseases, Public Health Service. 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