tbuckley/cabot-search huggingface dataset:
Cephalopod‐Inspired Miniaturized Suction Cups for Smart Medical Skin
Authors: Moon Kee Choi, Ok Kyu Park, Changsoon Choi, Shutao Qiao, Roozbeh Ghaffari, Jaemin Kim, Dong Jun Lee, Myungbin Kim, Wonji Hyun, Seok Joo Kim, Hye Jin Hwang, Seung‐Hae Kwon, Taeghwan Hyeon, Nanshu Lu, Dae‐Hyeong Kim
Journal: Advanced Healthcare Materials (2015)

Biomimetic miniaturized suction cups (mSCs) are designed for the patient friendly, dry adhesives of smart medical skin. Both strong van der Waals force and induced negative pressure by the ultrasoft mSCs facilitate tight skin coupling without discomfort or irritations, improve sensitivities of the embedded stretchable electronics for continuous vital sign monitoring, and enable multiple drug reloading without loss of the adhesion. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Safety and immunogenicity of double-dose versus standard-dose hepatitis B revaccination in non-responding adults with HIV-1 (ANRS HB04 B-BOOST): a multicentre, open-label, randomised controlled trial
Authors: David Rey, Lionel Piroth, Marie-Josée Wendling, Patrick Miailhes, Marie-Louise Michel, Cécilie Dufour, Georges Haour, Philippe Sogni, Alexandra Rohel, Faiza Ajana, Eric Billaud, Jean-Michel Molina, Odile Launay, Fabrice Carrat
Journal: The Lancet Infectious Diseases (2015)
Abstract 18205: Changing Characteristics and Outcomes of Patients with Chronic Heart Failure due to Left Ventricular Systolic Dysfunction: a Study Across Therapeutic Eras
Authors: Richard M Cubbon, Christopher P Gale, Lorraine C Kearney, Paul Brooksby, James Nolan, Keith A Fox, Adil Rajwani, Wazir Baig, Phillip D Batin, Matthew B Kahn, Azfar G Zaman, Ajay Shah, Steven Lindsay, Robert J Sapsford, Stephen B Wheatcroft, Klaus K Witte, Mark T Kearney
Journal: Circulation (2010)
Comparison of nedocromil sodium and sodium cromoglycate administered by pressurized aerosol, with and without a spacer device in exercise-induced asthma in children
Authors: A Comis, EA Valletta, L Sette, A Andreoli, AL Boner
Journal: European Respiratory Journal (1993)

To compare the effectiveness of nedocromil sodium (NS) and sodium cromoglycate (SCG) administered by metered dose inhaler (MDI) in preventing exercise-induced asthma (EIA), 12 asthmatic children with EIA were studied in a randomized, double-blind, cross-over, placebo-controlled study. NS and SCG were given by MDI alone, and by MDI with a 700 ml spacer device (Fisonair, Fisons, UK), in order to assess the benefit of using such a device. Following a baseline exercise challenge, the protective effect of NS, SCG or placebo was evaluated in each subject. The percentage fall in forced expiratory volume in one second, and percentage protection were measured. NS and SCG provided a significant and comparable protection from EIA, and both were better than placebo. No further improvement was observed after drug administration via the spacer. Both NS and SCG are effective in preventing EIA in children, when administered at the recommended clinical dose, and the use of a spacer for administering the drug provides no advantage if the technique of inhalation is good.
Breast cancer protein expression as a prognostic marker in sporadic epithelial ovarian cancer (EOC): An NCIC CTG OV.16 correlative study.
Authors: J. I. Weberpals, D. Tu, J. Squire, S. Islam, S. Amin, L. Pelletier, A. O'Brien, P. Hoskins, E. A. Eisenhauer
Journal: Journal of Clinical Oncology (2010)

5018 Background: There are no validated molecular biomarkers in EOC which correlate with prognosis or chemosensitivity. Breast cancer 1 (BRCA1) protein inactivation in sporadic EOC is common and reduced BRCA1 expression has been linked with platinum sensitivity. However, BRCA1 has not been clinically validated as a prognostic or predictive marker in EOC. Methods: The NCIC CTG-led Gynecologic Cancer Intergroup phase III trial, OV.16, compared topotecan/cisplatin followed by carboplatin/paclitaxel to standard carboplatin/paclitaxel in advanced EOC patients. With a median follow-up of 62 months (mo), there was no improvement in progression free survival (PFS) in the topotecan arm (Hoskins P, ASCO 2008). BRCA1 protein expression was determined by immunohistochemistry (IHC) on tissue microarrays of tumour samples from 251 Canadian patients (pts). IHC score was correlated with response rate (RR) and PFS using Cox proportional modeling adjusting for three independent prognostic factors identified in the main study (FIGO stage, residual disease (RD), and ECOG performance status). Preplanned subgroup analysis was performed for pts with minimal RD (microscopic or < 1 cm after debulking). Results: For the whole study group, BRCA1 score analyzed as a continuous variable showed no significant correlation between BRCA1 protein expression and PFS (adjusted HR = 1.15 [0.96, 1.37]; p = 0.12) or RR (HR = 0.89 [0.70, 1.12]; p = 0.32). In 116 pts with minimal RD, higher BRCA1 expression analyzed as a continuous variable was significantly associated with shorter PFS (HR = 1.40 [1.04, 1.89]; p = 0.03), but no significant correlation was found with RR. Exploratory analysis suggested that patients with minimal RD could be divided into low (BRCA1 ≤ 2.5) and high (BRCA1 > 2.5) expression groups. Pts with low BRCA1 expression had a longer PFS compared to those with high expression (median 24.7 and 16.6 mo, respectively; HR = 0.56 [0.35, 0.89]; p = 0.01). Conclusions: This study suggests that BRCA1 protein is a prognostic marker in sporadic EOC patients with minimal RD. Further research is needed to evaluate BRCA1 as a predictive biomarker and to target BRCA1 expression to enhance chemotherapeutic sensitivity. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration GlaxoSmithKline
UNIDIRECTIONAL ELECTROSTIMULATED CONVULSIVE THERAPY
Authors: EMERICK FRIEDMAN
Journal: American Journal of Psychiatry (1942)

1. Unidirectional electrostimulation was therapeutically applied in convulsive doses to 176 hospitalized psychiatric patients. The present report covers 2,746 convulsive reactions induced through left temple (negative), vertex-of-skull (positive) electrode placements. 2. The threshold convulsive dose, expressed in milliampere-seconds (product of intensity and duration of stimulation), was determined for four different types of unidirectional electrostimulation. The technique for obtaining threshold convulsive doses was described. 3. Type A. 1. stimulation consisting of rectified waves at 60/sec., each wave lasting 1/120 sec. with intervals of 1/120 sec. was tried in 154 instances. Practically 68 per cent of the trials gave convulsive thresholds at 50 mA.-sec. or less, with 45 per cent requiring intensity level of 46-60 mA. 4. Type A. 2. stimulation, designated as type A. 1. waves interrupted by a make commutator at 10/sec. giving rise to impulse bursts of 1/20 sec., was tried in 1,735 instances. In 83 per cent of the trials the convulsive dose was 50 mA.-sec. or less with 52 per cent in the 26-50 mA. sec. group and 31 per cent requiring 1-25 mA. sec. The intensity level was in the 16-30 mA. group in over 70 per cent of the trials. 5. Type C. 2. stimulation is described as 10/sec. commutator interrupted type C. 1. wave form. Type C. 1. is a 60/sec., slightly smoothed (filtered) rectified wave form, each wave lasting 1/6o sec. with no interval. of the 270 convulsive doses by type C. 2. stimulation, 66 per cent occurred at 50 mA.-sec. or less, with the intensity level in the 16-30 mA. group in 72 per cent of the trials. 6. Type C. 3. stimulation, described as the type C. 2. form further interrupted by rapid manipulation of the hand switch, was given 587 trials. Of these, practically all occurred at doses of 50 mA. sec. or less, with 80 per cent at 1-25 mA. sec. This markedly low convulsive dose more than offset the higher intensities required (46-90 mA. in 82 per cent of the trials). 7. Unidirectional electrostimulation seemed to offer convulsive doses markedly less than required by techniques utilizing the alternating current.
Diagnostic utility of cell block method combined with conventional smear cytology in the diagnosis of exudative pleural effusions accompanying lung cancer
Authors: Deniz Koksal, Funda Demirag, Hulya Bayiz, Adem Koyuncu, Neslihan Mutluay, Bahadir Berktas, Mine Berkoglu
Journal: European Respiratory Journal (2013)

Aim: Thoracenthesis is the first investigation to be done in a lung cancer patient with pleural effusion. We routinely use conventional smear studies (CSS) for diagnosis. We aimed to investigate the diagnostic utility of cell block (CB) method combined with CSS in the first thoracentesis.  Method: Forty lung cancer patients with exudative pleural effusions were included in this study. 10 ml of fresh pleural fluid sample was received from all patients in the initial evaluation. Pleural fluid sample was divided into two equal parts. One part was subjected to CSS and the other to CB method. Conventional smears were stained with Giemsa stain and Hematoxylin-Eosin (HE). CB sections were stained with HE and mucicarmine. CSS findings were grouped as “benign cytology” or “malignant cytology”. The “suspicion of malignancy” was grouped in the “benign cytology” group. The CB sections were evaluated for the presence of single tumor cell, acinary, papillary pattern, solid islands and staining with mucicarmine.  Results: There were 20 patients each in benign and malignant CSS group. In benign CSS group, adding CB method to CSS provided a diagnosis of malignancy in 4 more patients and the diagnosis of malignant effusion was increased by a ratio of (4/40) 10%. In malignant CSS group, adding CB technique provided the subtyping of lung cancer as adenocarcinoma in 7 patients (7/20, 35%).  Conclusion: Our study confirms the diagnostic utility of CB method combined with CSS. Therefore we recommend routine performing CB method combined with CSS in the first thoracentesis in a lung cancer patient with pleural effusion.
Serum immunoglobulin level is a useful marker for the risk of opportunistic infection in steroid dependent patients with chronic inflammatory airway diseases
Authors: Makiko Akahane, Nobuyuki Horita, Tomoko Takezawa, Takahiko Arai, Masako To, Yasuo To
Journal: European Respiratory Journal (2011)

Aim:  Patients with chronic inflammatory airway diseases such as severe asthma, pulmonary fibrosis often need to have long-term oral corticosteroids (O-CS). Patients who are administered O-CS, even a small amount, are susceptive for opportunistic infection (OI) such as pneumocystis pneumonia, fungal infection, herpes-zoster infection. The aim of this study is to clarify the usefulness of serum IgG as a marker for risk of OI in patients with long-term O-CS therapy.   Methods:  Seventeen patients with respiratory diseases (severe asthma 11, pulmonary fibrosis 5, Churg-Strauss syndrome 1) taking regular-use of O-CS were enrolled to this study. We retrospectively reviewed the medical records and collect the data about incidence of OI and serum IgG levels of the patients.   Results:  Seven out of 17 patients suffered from OI. The average IgG level in patients with OI (623±154 mg/dl, n=7) was significantly lower than patients without OI (879±188 mg/dl, p-value   Conclusion:  Serum IgG need to be monitored when patients were given O-CS. It is crucial to keep serum IgG levels more than 725 mg/dl to prevent OI.
Neutrophil elastase degraded elastin is elevated in serum of idiopathic pulmonary fibrosis
Authors: Jacob Hull Kristensen, Bidisha Dasgupta, Jannie Marie Sand, Carrie Brodmerkel, Mark Curran, Morten Asser Karsdal, Diana Julie Leeming
Journal: European Respiratory Journal (2014)

Introduction: Elastin is a signature protein of the lungs and loss of elasticity is a pathological feature of Idiopathic pulmonary fibrosis (IPF). The pathogenesis involves tissue turnover mediated by proteases upregulated during disease, especially neutrophil elastase (NE).  Aim: We developed an ELISA for the assessment of elastin degradation mediated by NE (EL-NE). The objective was to investigate the ability of this marker to non-invasively diagnose IPF.  Methods: A NE generated elastin neoepitope was chosen for monoclonal antibody generation for development of the EL-NE marker for the assessment of elastin NE degradation in serological samples. Elastin purified from lung was degraded  in vitro  cleaved by NE and a number of other proteinases and measured by EL-NE. The technical robustness of EL-NE was also tested. Furthermore, EL-NE was assessed in baseline serum samples of 124 IPF patients from a prior phase 2 study (CTgov reg. NCT00786201) and in 19 healthy controls.  Results: EL-NE was specific towards NE degraded lung elastin with three orders of magnitude compared to elastin degraded by other proteinases and intact elastin. The assay was found to be technical robust. EL-NE was significantly increased in IPF serum samples (p=0.010)) compared to healthy controls. Stratified for severity EL-NE could differentiate between mild (FVC≥ 80%) and moderate IPF (FVC 50-80%) with borderline significance (p=0.06).  Conclusion: We developed a technical robust marker that is specific for NE degraded elastin. Serum NE-derived elastin fragments were significantly elevated in IPF patients thus EL-NE may be a potential marker of diagnosis and possibly progression in IPF patients.
Recent life events and panic disorder
Authors: C Faravelli, S Pallanti
Journal: American Journal of Psychiatry (1989)

The authors assessed life events during the 12 months before the onset of panic disorder in 64 patients. Compared with a control group of 78 healthy subjects, patients with panic disorder had higher scores however life events were assessed, i.e., number of events, weighted normative scores, contextual scores, and number of subjects with major events. Independent life events (those beyond the subject's control) were also more numerous and more severe among the patients. The larger number of events experienced by the patients was due to the more frequent occurrence of life stress in the month before the onset of panic disorder. Loss events had the strongest relationship to panic disorder.
Non-invasive ventilatory (NIV) support for percutaneous endoscopic gastrostomy (PEG) tube insertion in patients with degenerative neuromuscular disease
Authors: Stephanie Hobbins, Heidi Jew, Caroline Davies, Nicola Wootton, Alban Tanajura, Karen Morrison, Hardev Pall, Rachel Cooney, Nazim Nathani
Journal: European Respiratory Journal (2014)

Introduction  Degenerative neuromuscular disease with or without bulbar involvement results in respiratory muscle weakness and poor nutrition. Placing PEG tubes can compromise ventilation due to supine positioning, sedation, procedure anxiety and pooling of secretions. We provide a regional PEG placement with NIV support service and here review its outcomes.  Method  A retrospective case review of 35 patients referred between 2011-13.  A dual-limb non-invasive ventilator with inbuilt oxygen sensor was used. Mask adaptation allowed use of a tracheal mount with entrailed endoscope thus ensuring full face mask interface. Patients had a 30minute NIV introduction pre-procedure.  Results  26 patients successfully underwent PEG insertion with NIV whilst 6 did not require NIV. 27 patients were given sedation. 2 had laryngeal spasm preventing completion in one and another settled with positioning and increased NIV. 1 procedure was abandoned due to anatomical abnormality.  Pre procedure SNIP ranged from 9-56, pO2 88-97% on room air and oxygen desaturation index from l1 to 37. Desaturation during the procedure (pO2 l85% on NIV and oxygen) was not related to measures of respiratory weakness or use of sedation.  Conclusion  NIV supported PEG placement remains a safe and effective service in patients with degenerative neuromuscular disease and respiratory muscle weakness.  Full face interface during the procedure is possible with mask adaptation. Although air leak is unavoidable, successful ventilation can be achieved using higher pressures and tidal volumes and entrailed oxygen. A robust multidisciplinary pathway is mandatory along with a skilled endoscopist.
Relationship between a functional IL-17 single nucleotide polymorphism and susceptibility to pulmonary tuberculosis
Authors: Juan Jose Ruiz, Elena Puente, María Ángeles Hoz, José Luis Arroyo, Ramón Agüero, Fernando Ausin, Maria Carmen Fariñas, Javier Gonzalo Ocejo-Vinyals
Journal: European Respiratory Journal (2013)

Background: Interleukin 17 (IL-17) plays an important role in immune response. Although low IL-17 levels have been associated with susceptibility to pulmonary tuberculosis (PTB), no study has evaluated if functional single nucleotide polymorphisms (SNPs) in IL-17A gene could influence risk of pulmonary tuberculosis.  Objectives: To assess if rs2275913 (G-152A) SNP, a functional SNP located in the promoter region of the IL-17 gene, could be associated with susceptibility or resistance to pulmonary tuberculosis (PTB) in a genetically homogeneous population (Cantabria, Northern Spain).  Methods: Through a case-control study, we studied the frequency of the different alleles and genotypes of the rs2275913 (G-152A) SNP. DNA obtained from one hundred and ninety-two patients with active PTB and 266 blood healthy donors was analysed by polimerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP).  Results: The frequency of the GG versus GA + AA genotype was significantly more frequent in patients with PTB than in control subjects assuming a dominant model (50.52% vs.39.10% respectively, OR = 1.59, 95% CI = 1.09-2.31, p = 0.015). Despite patients with PTB had higher serum IL-17 levels, we did not find an association of this SNP with IL-17 ex vivo production after stimulation with Mycobacterium tuberculosis (Mtb) antigens or phytohemagglutinin (PHA).  Conclusions: Our results would suggest an association between IL-17A rs2275913 G allele and GG genotype with susceptibility to PTB for the first time.
Diaphragm fatigue in self-paced running exercise of different durations
Authors: Thomas U. Wüthrich, Elisabeth C. Eberle, Christina M. Spengler
Journal: European Respiratory Journal (2011)

Introduction:  Diaphragm fatigue (DF) was shown to develop during high intensity constant-load exercise (CLE) above 85% of maximal oxygen consumption (VO 2max ). CLE does, however, not appropriately reflect field trial conditions where exercise intensity is regulated by complex feedforward and feedback mechanisms, possibly aiming to reduce/prevent DF. Therefore, the development of DF was assessed in 11 well-trained athletes (age=31±4 yrs, VO 2max =66.7±4.6 mlmin -1 kg -1 ) in 15 and 30min running time trials (TT). We hypothesized that DF would be larger in the 30TT where more time is spent above 85%VO 2max .   Methods:  Before and 4min after completion of the TTs, esophageal and gastric pressures were assessed to calculate transdiaphragmatic twitch pressures (P di,tw ) during cervical magnetic stimulation.   Results:  All subjects developed DF (P di,tw  reduction, ΔP di,tw  ≥10%) in the 15TT and 7/11 subjects in the 30TT. On average, ΔP di,tw  was 23.0±6.5 (15TT) and 18.5±12.1% (30TT; p=0.13). Mean exercise intensities were 89.4±3.5 (15TT) and 86.0±3.7%VO 2max  (30TT; p=0.07) with similar mean durations above 85%VO 2max  (11.9±2.0min; range: 7-14min; 15TT) and (16.2±9.7min; 1-28min; 30TT; p=0.19). The individual between-TT difference in ΔP di,tw  did not correlate with the difference in time spent above 85%VO 2max  (R 2 =0.20) but correlated with the difference in the average exercise intensity above 85%VO 2max  (R 2 =0.49; p=0.02).   Conclusion:  In TT-conditions, the degree of DF is not related to the duration spent above 85%VO 2max  but it is related to the exercise intensity when exercising above the 85%VO 2max -threshold.
Comorbidity profiles among patients with bullous pemphigoid: a nationwide population-based study
Authors: Y.J. Chen, C.Y. Wu, M.W. Lin, T.J. Chen, K.K. Liao, Y.C. Chen, C.Y. Hwang, S.Y. Chu, C.C. Chen, D.D. Lee, Y.T. Chang, W.J. Wang, H.N. Liu
Journal: British Journal of Dermatology (2011)

Journal Article Comorbidity profiles among patients with bullous pemphigoid: a nationwide population‐based study Get access Y.J. Chen, Y.J. Chen DermatologyDermatology Search for other works by this author on: Oxford Academic Google Scholar C.Y. Wu, C.Y. Wu Internal Medicine, Taichung Veterans General Hospital, Taichung, TaiwanInternal Medicine Search for other works by this author on: Oxford Academic Google Scholar M.W. Lin, M.W. Lin Institute of Public Health, National Yang‐Ming University, Taipei, Taiwan Search for other works by this author on: Oxford Academic Google Scholar T.J. Chen, T.J. Chen Family Medicine Search for other works by this author on: Oxford Academic Google Scholar K.K. Liao, K.K. Liao Neurology Search for other works by this author on: Oxford Academic Google Scholar Y.C. Chen, Y.C. Chen Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany Search for other works by this author on: Oxford Academic Google Scholar C.Y. Hwang, C.Y. Hwang DermatologyDermatology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei 112, Taiwan Search for other works by this author on: Oxford Academic Google Scholar S.Y. Chu, S.Y. Chu DermatologyDermatology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei 112, Taiwan Search for other works by this author on: Oxford Academic Google Scholar C.C. Chen, C.C. Chen DermatologyDermatology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei 112, Taiwan Search for other works by this author on: Oxford Academic Google Scholar D.D. Lee, D.D. Lee DermatologyDermatology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei 112, Taiwan Search for other works by this author on: Oxford Academic Google Scholar ... Show more Y.T. Chang, Y.T. Chang DermatologyDermatology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei 112, Taiwan Yun‐Ting Chang. E‐mail: ytchang@vghtpe.gov.tw Search for other works by this author on: Oxford Academic Google Scholar W.J. Wang, W.J. Wang DermatologyDermatology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei 112, Taiwan Search for other works by this author on: Oxford Academic Google Scholar H.N. Liu H.N. Liu DermatologyDermatology, Taipei Veterans General Hospital, No. 201, Sec. 2, Shipai Road, Beitou District, Taipei 112, TaiwanDepartment of Dermatology, National Defence Medical Centre, Taipei, Taiwan Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 165, Issue 3, 1 September 2011, Pages 593–599, https://doi.org/10.1111/j.1365-2133.2011.10386.x Published: 01 September 2011