tbuckley/cabot-search huggingface dataset:
Prevention of Falls and Injuries in Residential Care
Authors: Javier Damián
Journal: Annals of Internal Medicine (2002)

Letters19 November 2002Prevention of Falls and Injuries in Residential CareJavier Damián, MDJavier Damián, MDNational Center for Epidemiology; Carlos III Institute of Health; 28029 Madrid, Spain (Damián)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-10-200211190-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Some issues arise when trying to interpret the results of Jensen and colleagues' study on prevention of falls and injuries in residential care (1). Although the study had some limitations (effective randomization was not performed, and the “Hawthorne effect” played a role), it is not difficult to assume that the overall intervention worked; most of the measures used were sensible and supported by evidence. However, researchers might want to know which of the strategies or combinations of strategies were efficacious, or at least which were more heavily weighted. Given the study design, it is not possible to ...Reference1. Jensen J, Lundin-Olsson L, Nyberg L, Gustafson Y. Fall and injury prevention in older people living in residential care facilities. A cluster randomized trial. Ann Intern Med. 2002;136:733-41. [PMID: 12020141] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: National Center for Epidemiology; Carlos III Institute of Health; 28029 Madrid, Spain (Damián) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoFall and Injury Prevention in Older People Living in Residential Care Facilities: A Cluster Randomized Trial Jane Jensen , Lillemor Lundin-Olsson , Lars Nyberg , and Yngve Gustafson Prevention of Falls and Injuries in Residential Care Jane Jensen , RPT Lillemor Lundin-Olsson , and RPT Yngve Gustafson Metrics 19 November 2002Volume 137, Issue 10Page: 856-857KeywordsFalls ePublished: 19 November 2002 Issue Published: 19 November 2002 CopyrightCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Cytosine Arabinoside versus Virus or Man?
Authors: Adolf W. Karchmer, Martin S. Hirsch
Journal: New England Journal of Medicine (1973)

The development of pyrimidine and purine nucleoside derivatives and the demonstration of their in vitro and in vivo antiviral effects have been among the major achievements of viral chemotherapy during the past decade. Nevertheless, despite increasing use of such agents to treat disseminated varicella–zoster, herpes-simplex encephalitis, herpes-simplex neonatorum and cytomegalic inclusion disease there is no convincing evidence of their clinical efficacy.The possibilities and limitations in the development of antiviral agents become clearer if several features of virus–cell interaction are understood. In the first place, viruses are unique parcels of genetic material that as obligate intracellular parasites are dependent on . . .
Warfarin Treatment After Bioprosthetic Aortic Valve Replacement
Authors: Hadi Daood Toeg, Lise M. Bjerre, Marc Ruel
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thromboxane synthesis is increased by upregulation of cytosolic phospholipase A<sub>2</sub> and cyclooxygenase‐2 in peripheral polymorphonuclear leukocytes during bacterial infection in childhood
Authors: Masafumi Zaitsu, Yuhei Hamasaki, Shinji Nishimura, Muneaki Matsuo, Ichiro Fujita, Eiichi Ishii
Journal: American Journal of Hematology (2003)

Abstract Prostaglandins (PGs) and thromboxane (TX) are important mediators of inflammation. Recent studies revealed that PG and TX synthesis is controlled by the regulation of PG‐ and TX‐synthesizing enzymes. In this study, we examined the TX synthesis and the expression of TX‐synthesizing enzymes in activated peripheral polymorphonuclear leukocytes (PMNs) obtained from children with bacterial infection. Blood samples were obtained from controls and patients with bacterial infection. A23187‐stimulated production of TXB 2 , a stable metabolite of TXA 2 in PMNs, was measured by a specific radioimmunoassay. The mRNA expression of cytosolic phospholipase A 2 (cPLA 2 ), cyclooxygenase (COX)‐1, COX‐2, and TXA 2 synthase was determined by RT‐PCR. The synthesis of TXB 2 in PMNs was significantly increased in the patients [925.0 (550.0–1100.0) pg/10 6 cells], compared with the controls [550.0 (450.0–775.0) pg/10 6 cells]. The mRNA expression for cPLA 2 and COX‐2 in PMNs was also enhanced in the patients. The results indicate that TX production in PMNs is significantly increased through possible transcriptional mechanisms of cPLA 2 and COX‐2 during bacterial infection in children. The upregulation of TXA 2 synthesis may contribute to the process of acute inflammatory reaction caused by bacterial infection. Am. J. Hematol. 72:115–120, 2003. © 2003 Wiley‐Liss, Inc.
Is the magnetic resonance imaging proton spin-lattice relaxation time a reliable noninvasive parameter of developing liver fibrosis?
Authors: Robert A. F. M. Chamuleau, Joris H. N. Creyghton Ineke De Nie, Marinus A. Moerland, Otto R. Van der Lende, Jaap Smidt
Journal: Hepatology (1988)

During the development of liver fibrosis in rats by an individual dose-titrated CCl 4 administration, hepatic proton spin-lattice relaxation time (T 1 ) has been measured in vivo every 2 weeks for 8 weeks. Liver content of collagen, triglycerides and water has been measured biochemically in biopsy material. After 4 weeks of CCl 4 treatment, T 1 increased signifcantly and remained at the same level, whereas liver collagen reached its maximum at 8 weeks. It is concluded that, under our experimental conditions, increased hepatic T 1 represents drug-induced edema and that hepatic T 1 is not a reliable noninvasive parameter for developing liver fibrosis in vivo .
Thrombocytopenia and Iron Deficiency
Authors: DAVID SONNEBORN
Journal: Annals of Internal Medicine (1974)

Letters1 January 1974Thrombocytopenia and Iron DeficiencyDAVID SONNEBORN, PH.D.DAVID SONNEBORN, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-1-111 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The platelet count in iron-deficiency anemia is typically elevated. Severe iron deficiency may cause thrombocytopenia (1, 3); this has been shown in children (4). We have been unable to discover any report of low platelets associated with iron-deficiency anemia in an adult. The response to iron in an adult with a severe iron-deficiency anemia and thrombocytopenia but with normal serum folate and vitamin B12 levels is described below; an apparent case of iron-deficiency thrombocytopenia.A 31-year-old black women presented to the emergency room with flank pain and hematuria of 1 month's duration. For the previous year she...References1. RICHARDSON F: Effect of severe hemorrhage on the number of blood platelets in blood from the peripheral circulation of rabbits. J Med Res 13:99-103, 1904 MedlineGoogle Scholar2. SCHLOESSERKIPPWENZEL LMF: Thrombocytosis in iron deficiency anemia (abstract). Clin Res 11:295, 1965 Google Scholar3. HEATHPATEK CA: The anemia of iron deficiency. Medicine (Baltimore) 16:267-350, 1937 CrossrefGoogle Scholar4. GROSSKEEFERNEWMAN SVA: The platelets in iron deficiency anemia. I. The response to oral and parenteral iron. Pediatrics 34:315-323, 1964 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Health Sciences Center Medical College of Virginia Virginia Commonwealth University Richmond, Virginia PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPlatelet-to-Lymphocyte Ratio Predicts Contrast-Induced Acute Kidney Injury in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary InterventionSerum ferritin in plateletpheresis and whole blood donorsAn analysis of the relationship between severe iron deficiency anemia and thrombocytopeniaAn Unusual Case of ThrombocytopeniaThrombopénie ferriprive : un diagnostic différentiel rare du purpura thrombopénique auto-immunPlatelet counts in adults with iron deficiency anemiaThrombocytopenia in Children With Severe Iron DeficiencyThrombocytopenia Associated with Repletion of Lron in Lron-Deficiency AnemiaSevere thrombocytopenia in iron deficiency anemiaPlatelet aggregation in iron deficiency anemiaIron Responsive ThrombocytopeniaHOWARD SCHER, M.D., ROBERT SILBER, M.D. 1 January 1974Volume 80, Issue 1Page: 111-111KeywordsChildrenEmergency departmentFolic acidIron deficiencyIron deficiency anemiaPlatelets Issue Published: 1 January 1974 PDF downloadLoading ...
Hypogonadism Due to Pituicytoma in an Identical Twin
Authors: Harvey H Newnham, Livia M Rivera-Woll
Journal: New England Journal of Medicine (2008)

A 43-year-old man, who is an identical twin, presented with a 2-year history of lethargy, weakness, and headaches and a several-year history of gradual loss of body hair and declining libido. He had undergone left orchidopexy at 6 years of age. A physical examination revealed features of hypopituitarism and hypogonadism, including central adiposity, nipple pallor, proximal muscle wasting, preservation of scalp hair, loss of body hair, gynecomastia, and right and left testicular volumes of 12 ml and 5 ml, respectively (normal volume, >15). A remarkable feature was the contrast in appearance between the hypogonadal patient (Panel A, right side) and . . .
CONTAMINATED ULTRASONIC NEBULIZERS
Authors: EVERETT R. RHOADES
Journal: Annals of Internal Medicine (1969)

Letters and Comments1 April 1969CONTAMINATED ULTRASONIC NEBULIZERSEVERETT R. RHOADES, M.D.EVERETT R. RHOADES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-4-871 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:The paper entitled "A Hospital Outbreak ofSerratia marcescensAssociated with Ultrasonic Nebulizers" by Ringrose and associates (Ann. Intern. Med. 69: 719, 1968.) suggests that prior publications dealing with contamination of ultrasonic nebulizers had not appeared. We carefully searched the standard indexes and unfortunately did not encounter the series of three papers by Hugh L. Moffet and co-workers published in the July 1967 volume ofAmerican Journal of Diseases of Childhooddealing with contaminated mists, distilled water, and inhalation therapy equipment. This letter is to call attention to the prior publications. The authors of these papers studied... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: EVERETT R. RHOADES, M.D.Affiliations: Department of Medicine University of Oklahoma Medical Center Oklahoma City, Okla. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1969Volume 70, Issue 4Page: 871-871KeywordsInhalationSerratia marcescens ePublished: 1 December 2008 Issue Published: 1 April 1969 PDF downloadLoading ...
Washington University School of Medicine
Authors: William A. Peck
Journal: JAMA (1991)

Great medical schools of the 20th century nurture the creative energies of incredibly gifted students, teachers, investigators, practitioners, and community servants. Their development attests to the diligence of wise thinkers and planners-true visionaries who made bold, imaginative choices. In 1891, however, not even the most daring visionary would have predicted greatness for the newly created Medical Department of Washington University, then one of nearly a dozen medical colleges in St Louis alone. It was during the first decade of this century that the leadership of Washington University resolved to build an outstanding medical school. Although many contributed, much credit can be assigned to three men: Robert Summers Brookings, chairman of the Washington University Corp; David F. Houston, chancellor of the university; and Abraham Flexner, pioneer reformer of American medical education as representative of the Carne
Alteration of Gene Expression in Human Hepatocellular Carcinoma with Integrated Hepatitis B Virus DNA
Authors: Akihiro Tamori, Yoshihiro Yamanishi, Shuichi Kawashima, Minoru Kanehisa, Masaru Enomoto, Hiromu Tanaka, Shoji Kubo, Susumu Shiomi, Shuhei Nishiguchi
Journal: Clinical Cancer Research (2005)

Abstract Purpose: Integration of hepatitis B virus (HBV) DNA into the human genome is one of the most important steps in HBV-related carcinogenesis. This study attempted to find the link between HBV DNA, the adjoining cellular sequence, and altered gene expression in hepatocellular carcinoma (HCC) with integrated HBV DNA. Experimental Design: We examined 15 cases of HCC infected with HBV by cassette ligation–mediated PCR. The human DNA adjacent to the integrated HBV DNA was sequenced. Protein coding sequences were searched for in the human sequence. In five cases with HBV DNA integration, from which good quality RNA was extracted, gene expression was examined by cDNA microarray analysis. Results: The human DNA sequence successive to integrated HBV DNA was determined in the 15 HCCs. Eight protein-coding regions were involved: ras-responsive element binding protein 1, calmodulin 1, mixed lineage leukemia 2 (MLL2), FLJ333655, LOC220272, LOC255345, LOC220220, and LOC168991. The MLL2 gene was expressed in three cases with HBV DNA integrated into exon 3 of MLL2 and in one case with HBV DNA integrated into intron 3 of MLL2. Gene expression analysis suggested that two HCCs with HBV integrated into MLL2 had similar patterns of gene expression compared with three HCCs with HBV integrated into other loci of human chromosomes. Conclusions: HBV DNA was integrated at random sites of human DNA, and the MLL2 gene was one of the targets for integration. Our results suggest that HBV DNA might modulate human genes near integration sites, followed by integration site–specific expression of such genes during hepatocarcinogenesis.
What is a good death?: Pathologists could provide new spaces to say goodbye to the dead
Authors: M. Drlicek
Journal: BMJ (2003)

Editor—A good death includes the way we say goodbye to the dead person.1 However, an appropriate environment for such goodbyes is missing in most hospitals.2,3 This important act has to happen in bathrooms, cold storage chambers, or necropsy rooms. Guidelines for establishing an appropriate environment and the necessary equipment are lacking.

We suggest that such a room must fit different cultures and religious persuasions. The challenge for artists, in collaboration with pathologists, is to create a room that is fitting for a religious ceremony as well as a silent atheistic ritual, without obstructing either.4

The room where relatives wait before encountering a familiar person as a dead body requires thought. We decided against gentle music, favouring visual diversions such as pictures and aphorisms  the wall to give relatives an opportunity to look, read, and become absorbed without embarrassment. Relatives should also be informed about the possibility of a death mask.

The room for the ceremony should seem warm, perhaps from light falling through a stained glass window. A crucifix, prayer rugs, the Bible, Koran, or Torah should be provided as required. An opportunity for ritual ablution should be given, and there should also be a hidden sign pointing to Mecca.

The corpse is laid out  an altar-like square stone in the centre of the room. Its orientation is psychologically important. It faces the light rather than the entrance signifying that there is no way back:

O pleasant light, my confidence and hope, conduct us thou, he cried, on this new way.5
Unraveling Severe Sepsis
Authors: Derek C. Angus, Mark A. Crowther
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2429: Airway necrosis after salvage esophagectomy.
Authors: Norimitsu Tanaka, Nobukazu Hokamura, Yuji Tachimori
Journal: Cancer Research (2013)

Abstract Background: Recently definitive chemoradiotherapy (CRT) without surgery has been accepted as an alternative treatment for esophageal cancer. However, unfortunately, the tumors of 5-33% patients were resistant to CRT and persistent disease was detected soon after treatment, and 16-54% patients initially showed a response but locoregional disease was discovered later. Salvage esophagectomy is the sole curative intent treatment for patients with persistent or recurrent locoregional disease after definitive CRT for esophageal carcinoma. However, salvage esophagectomy is a very high-risk operation, and airway necrosis is a fatal complication. Methods: Between 1997 and 2007, 49 patients with thoracic esophageal squamous cell carcinoma underwent salvage esophagectomy after definitive CRT. All patients received more than 50 Gy of radiation plus concurrent chemotherapy for curative intent. We retrospectively compared patients with and without airway necrosis. Additionally, airway necrosis was categorized primary necrosis and secondary necrosis according to the cause of necrosis, and operative procedures related to airway necrosis were investigated. Result: Overall 23of 49 patients had at least one complication (morbidity: 46.9%), and 5 died during their hospitalization (mortality: 10.2%). Airway necrosis occurred in five patients (10.2%), of four patients (80%) died during their hospitalization. Airway necrosis seemed to be closely related to operative procedures, such as resection of bronchial artery (BA), cervical and subcarinal lymph node dissection (LND) and reconstruction route. Primary necrosis occurred in 3 patients with resection of BA, cervical LND, or subcarinal LND. And bronchogastric fistula following necrosis of gastric conduit occured in 2 patients reconstructed through posterior mediastinal route. Conclusions: Airway necrosis is a highly lethal complication after salvage esophagectomy. It is important in salvage esophagectomy to take airway blood supply into consideration sufficiently and to reconstruct through retrosternal route to prevent bronchogastric fistula. Citation Format: Norimitsu Tanaka, Nobukazu Hokamura, Yuji Tachimori. Airway necrosis after salvage esophagectomy. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2429. doi:10.1158/1538-7445.AM2013-2429
Charting a Path From Comparative Effectiveness Funding to Improved Patient-Centered Health Care
Authors: Patrick H. Conway
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Renal Function During Long-Term Treatment of Hypertension with Minoxidil
Authors: HELEN C. MITCHELL
Journal: Annals of Internal Medicine (1980)

We examined the effect of long-term blood pressure control on renal function in 41 patients with refractory hypertension by using minoxidil, sympathetic suppressants, and diuretics continuously for 6 months to 7½ years. In 15 of 32 patients with benign hypertension, the serum creatinine concentration increased by more than 1 mg/dL, with nine of 15 requiring hemodialysis. Analysis of 1/serum creatinine versus time plots indicated that use of minoxidil delayed the onset of end-stage renal failure in some patients for up to 6 years. In the remaining 17 patients with benign hypertension, renal function remained stable with no decreases greater than 2 mg/dL. Four of nine patients presenting with malignant hypertension had marked and sustained improvement in renal function, although three initially required hemodialysis. The mean serum creatinine concentration in these four patients fell from 9.7 to 2.9 mg/dL. Thus, impressive renal functional improvement may occur with minoxidil use in some patients with malignant hypertension.