tbuckley/cabot-search huggingface dataset:
Abstract 1008: Prevalence of FoxM1 expression in Middle Eastern epithelial ovarian carcinoma patients and its potential role as a therapeutic target
Authors: Maqbool Ahmed, Zeenath Jehan, Prashant Bavi, Azhar R. Hussain, Aisha Saad Olayan, Thangavel Saravanan, Fouad Al Dayel, Samir Ghourab, Shahab Uddin, Khawla S. Al Kuraya
Journal: Cancer Research (2011)

Abstract FoxM1 is a member of Forkhead transcription factors and its expression has been found to be altered in a variety of cancers. Several studies have indicated the importance of FoxM1 in cell proliferation, as it is a key cell-cycle regulator of both the transition from G1 to S phase and the progression to mitosis. In this study, we investigated the functional consequences of FoxM1 signaling pathway in a large cohort of epithelial ovarian cancer (EOC) tumor (patient) samples, panel of cell lines, and in nude mouse model. Using immunohistochemistry, FoxM1 was detected in 47.4% (64/135) of the ovarian tumor samples. EOC with FOX-M1 expression showed a significantly better disease free survival(p=0.0148) of 21.9 months as compared to the EOC with low FOX-M1 expression(14.4 months). Overexpression of FoxM1 was also significantly associated with activated p-AKT(p=0.0072), SKP2(p=0.0121), p-Rb(p=0.0357), UBE2C(p=0.0106), FAS-N(p=0.0179), PIK3CA p110αIHC(p=0.0362), XIAP(p=0.0033) and tumor proliferative marker Ki167 (p&amp;lt;0.0001). Treatment of a panel of EOC cell lines with thiostrepton, an inhibitor of FoxM1, inhibited cell proliferation and induced apoptosis. Thiostrepton treatment caused apoptosis by involving the mitochondrial pathway, through activation of caspases and down regulation of XIAP and survivin. FoxM1 inhibition in EOC cells by thiostrepton resulted in the down regulation of Skp2 and accumulation of p21, possibly causing G2/M arrest. Furthermore, FoxM1 inhibition also down regulated cell migration and cell invasion in EOC cells by inducing decreased secretion of VEGF and MMP2. In addition, pharmacological inhibition of FoxM1 or its gene silencing with siRNA causes downregulation of FoxM1, AKT and its associated downstream signaling molecules. Altogether, these results suggest that FoxM1 and its role in the deregulated survival pathway make this a potential target for therapeutic intervention of EOC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1008. doi:10.1158/1538-7445.AM2011-1008
Perfusion Scintigraphy in the Diagnosis of Pulmonary Embolism A Self-Assessment Quiz
Authors: P EGERMAYER, M D RUTLAND
Journal: Clinical Nuclear Medicine (1982)

The authors present ten case reports with lung scintigrams in a format suitable for a self-assessment quiz. The first seven cases include perfusion scintigrams and the final diagnosis was established by postmortem examination. The last three studies include ventilation images (using nebulized Tc-99m tin colloid) and the final diagnosis established by nonradionuclide studies. The authors believe this quiz demonstrates the necessity for ventilation studies when using lung scintigraphy for a positive diagnosis.
Helping families with a mentally handicapped member.
Authors: V Shennan
Journal: BMJ (1981)

.^--s^ The incidence of mental handicap has /J? \h ^een estimatec^5 using criteria based /!_ 9 ^JjjP IL ftA on an intelligence quotient of below / Hl %3r Jr  ^m cnudren of school age, as between I ^^.3?^y I 3 anc^ 4 per 1000 in most developed I . | 1 countries. It is reasonable to assume  Interna?onal learc? / the same incidence, worldwide, in  Disabled People / countries from which statistical data x. y/ are unobtainable. Down's syndrome accounts for almost one-third of these figures. Many parents will first be told of their child's handicap by the medical or nursing staff in the obstetric unit. In some cases, genetic screening may have identified a potentially handicapped infant before delivery, and the parents may have been offered termination; this is sometimes refused. Cases still occur where, in spite of screening, a handicapped baby has been born to parents who have previously been advised that the infant would be normal. Some infants suffer damage during birth or in the immediate postnatal period, which is considered by the parents to have been avoidable. Medical practitioners are likely, therefore, to be dealing from the start with a family under great stress and to find the distress and anger directed at them personally, though this may not be openly expressed. This calls for immense skill; compassion and the shared sense of acute disappointment on the part of the doctor must not be allowed to obscure the immediate practical help which alone will alleviate some of the suffering. Comfort is usually derived from positive information ?in other words, what can be done by the parents to make the most of their child in spite of the handicap?rather than an attitude of wait and see. The doctor who has information about the particular handicap should put his knowledge into simple unambiguous language that is not inherently hurtful; if he has no precise knowledge of the particular condition he should have the courage to say so and be willing to refer the parents to others who may be able to help. Of particular value is the specialist group of parents with a similar condition to cope with. Medicine has a part to play in the management of mental handicap, but best results are obtained from co-operation with a multidisciplinary team. It is not always realised that the mother of a handicapped baby experiences grief comparable with that of the mother of a stillborn child. In a real sense she has lost the healthy baby she awaited with joy and has now to come to terms with a tragedy?not finite as a stillbirth, but destined to continue for the whole life of the child. We can make a few practical points that may help practitioners, and list them in the order in which they most frequently arise. Antenatal counselling
Prevention: Where Do We Draw the Line?
Authors: Robert B. Brown, Adrian Dafcik, Michael Friedland
Journal: Annals of Internal Medicine (1991)

Letters15 April 1991Prevention: Where Do We Draw the Line?Robert B. Brown, MD, Adrian Dafcik, MD, Michael Friedland, MDRobert B. Brown, MDSearch for more papers by this author, Adrian Dafcik, MDSearch for more papers by this author, Michael Friedland, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-8-706_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editors: The articles by Schwartz and colleagues (1) and Lewis and coworkers (2) reporting survey results regarding internists' practice of disease prevention counseling were interesting and informative. Without disputing the potential benefit of such counseling, we question the necessity and appropriateness of physicians' assuming the responsibility for advising patients to use seat belts. To what degree is it appropriate to expect physicians to become involved in attempting to modify a patient's lifestyle and habits?No one would seriously disagree with counseling against alcohol, drug, or tobacco abuse, because these agents are clearly associated with potential adverse health consequences....References1. Schwartz J, Lewis C, Clancy C, Kinosian M, Radany M, and Koplan J. Internists' practices in health promotion and disease prevention. A survey. Ann Intern Med. 1991;114:46-53. LinkGoogle Scholar2. Lewis C, Clancy C, Leake B, and Schwartz J. The counseling practices of internists. Ann Intern Med. 1991;114:54-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Robert B. Brown, MD; Adrian Dafcik, MD; Michael Friedland, MDAffiliations: St. Vincent's Medical Center Bridgeport, CT 06606 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySafety belt nonuse by internal medicine patients: A missed opportunity in clinical preventive medicine 15 April 1991Volume 114, Issue 8Page: 706-707KeywordsAlcoholsDrug abuseDrugsHabits ePublished: 1 December 2008 Issue Published: 15 April 1991 PDF downloadLoading ...
Peptide immunotherapy in allergic asthma generates IL-10–dependent immunological tolerance associated with linked epitope suppression
Authors: John D. Campbell, Karen F. Buckland, Sarah J. McMillan, Jennifer Kearley, William L.G. Oldfield, Lawrence J. Stern, Hans Grönlund, Marianne van Hage, Catherine J. Reynolds, Rosemary J. Boyton, Stephen P. Cobbold, A. Barry Kay, Daniel M. Altmann, Clare M. Lloyd, Mark Larché
Journal: The Journal of Experimental Medicine (2009)

Treatment of patients with allergic asthma using low doses of peptides containing T cell epitopes from Fel d 1, the major cat allergen, reduces allergic sensitization and improves surrogate markers of disease. Here, we demonstrate a key immunological mechanism, linked epitope suppression, associated with this therapeutic effect. Treatment with selected epitopes from a single allergen resulted in suppression of responses to other (“linked”) epitopes within the same molecule. This phenomenon was induced after peptide immunotherapy in human asthmatic subjects and in a novel HLA-DR1 transgenic mouse model of asthma. Tracking of allergen-specific T cells using DR1 tetramers determined that suppression was associated with the induction of interleukin (IL)-10+ T cells that were more abundant than T cells specific for the single-treatment peptide and was reversed by anti–IL-10 receptor administration. Resolution of airway pathophysiology in this model was associated with reduced recruitment, proliferation, and effector function of allergen-specific Th2 cells. Our results provide, for the first time, in vivo evidence of linked epitope suppression and IL-10 induction in both human allergic disease and a mouse model designed to closely mimic peptide therapy in humans.
Bilateral Ovarian Metastases From Breast Carcinoma on FDG PET-CT
Authors: Linh Ho, Vicki Quan, Robert Henderson
Journal: Clinical Nuclear Medicine (2007)

We report the PET-CT appearance of bilateral ovarian metastases in a 51-year-old woman with a history of right breast carcinoma with osseous metastasis diagnosed 14 years earlier. The colon and stomach are the most common primary tumor sites in ovarian metastasis, followed by the breast, lung, and contralateral ovary. It is important to consider this form of neoplasm in the differential diagnosis because the treatment and prognosis will be different from a dyssynchronous primary tumor.
IDENTIFICATION OF VULNERABLE ELDERLY BEFORE CARDIAC SURGERY: A COMPARISON OF DIFFERENT SURVEY SCALES
Authors: Jonathan Afilalo, Salvatore Mottillo, Karen P. Alexander, Jean-Francois Morin, Nicolas Noiseux, Louis P. Perrault, Mark J. Eisenberg, Jean-Francois Boivin, Johanne Monette, Howard Bergman
Journal: Journal of the American College of Cardiology (2011)
Biopsy of Occult Breast Lesions and Professional Liability-Reply
Authors: Jack E. Meyer
Journal: JAMA (1990)

In Reply.—  Dr Darios questions the advisability of not performing a biopsy of innocuous-appearing occult mammographic abnormalities on the basis of a possible malpractice judgment. Despite published and broadly accepted standards, there is unquestionably a wide variation in the criteria used by individual radiologists to support biopsy of an occult breast abnormality. This recommendation is usually based on one or more of the following factors: (1) the degree of experience and confidence of the radiologist in separating benign from malignant abnormalities, (2) the proper utilization of magnification, compression spot films, ultrasound, and/or prior comparison mammograms, and (3) the level of concern over possible litigation when recommending a 6-month follow-up rather than biopsy. Equivocal official mammographic reports diminish the value of the interpretation and almost always result in excision being performed.  To orient one's practice strictly toward avoidance of litigation is unfair to our patients. We are certain that Dr Darios
Abstract 3769: Metabolic activation of batracylin and N-acetylbatracylin to reactive metabolites that bind protein and DNA: Possible role in toxicity
Authors: Sarah A. Buhrow, Mary Kuffel, Chad Walden, Joel M. Reid, Joseph Covey, Matthew M. Ames
Journal: Cancer Research (2012)

Abstract Batracylin (NSC 320846, BAT) is a heterocyclic arylamine and topoisomerase II inhibitor shown to be active in murine tumor models, but with demonstrated species differences in toxicity associated with metabolism to N-acetylbatracylin (NBAT) by N-acetyltransferase (NAT). BAT is a preferential substrate of human NAT2. Accordingly, production of NBAT should be subject to population variability as a function of NAT2 polymorphisms. A phase I clinical trial of BAT in patients with advanced cancer and slow acetylator NAT2 phenotypes to reduce the risk of NBAT-related toxicity found a dose-limiting toxicity (DLT) of cystitis/hemorrhagic cystitis. In subsequent in vitro and in vivo preclinical studies to elucidate metabolic pathways that might contribute to BAT toxicity, we found oxidative metabolites and thiol conjugates of BAT and NBAT (MM Ames et al, Cancer Res 2011;71(8 Suppl):Abstract nr 1303). Since these data are consistent with metabolic activation of BAT to potentially toxic metabolites, we assessed formation of reactive intermediates as measured by covalent binding (CB) to protein and DNA or by formation of glutathione conjugates. Radiolabeled BAT and NBAT were incubated with 3-MC-induced rat (r), human (h) and dog (d) liver microsomes (LM), as well as with recombinant human cytochromes P450 (CYPs) with or without added DNA. NADPH-dependent BAT protein and DNA CB were detected in all microsomal preparations (see table below). NADPH-dependent NBAT protein CB was detected in all microsomal preparations except hCYP1B1. NADPH-dependent NBAT DNA CB was detected in all microsomal preparations except 3MC-rLM. We also detected a glutathione conjugate of mono-hydroxy BAT by lc/ms/ms analysis when BAT was incubated with hLM in the presence of glutathione and NADPH. Thus, CYP-catalyzed oxidation of BAT yields reactive metabolites that that bind protein and DNA and may contribute to drug-related DLT. Supported in part by NCI Contract N01-CM-52206. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3769. doi:1538-7445.AM2012-3769
The Low Risk of Hepatitis B in Rural Hospitals
Authors: Jeffrey R. Harris
Journal: JAMA (1984)

To determine the risk of hepatitis B virus infection for rural hospital employees, we obtained serum and a completed questionnaire from each of 2,064 employees of 11 rural hospitals. Only 96 (4.7%) employees had hepatitis B virus markers. Increased marker prevalence was significantly associated with prior residence in a city with a population of greater than 100,000 (odds ratio, 2.9; 95% confidence interval, 1.6 to 5.2) and increasing blood contact (odds ratio, 1.6; confidence interval, 1.2 to 2.3); however, the association with blood contact was not significant when we limited analysis to the 836 employees who had never lived in a city. We conclude that the risk of hepatitis B virus infection for these rural hospital employees is low, probably because the incidence of hepatitis B in rural areas is low.
The Effects of Brief Hypnotherapy in a Series of Psychosomatic Problems
Authors: F.H. Frankel
Journal: Psychotherapy and Psychosomatics (1973)

The use of hypnosis on its own or in association with other treatment procedures produced improvement, subjectively and/or objectively, in 17 of a series of 50 patients suffering from a variety of psychosomatic problems. All 50 patients were tested for trance capacity. When this was present to any reasonable degree, the patients were immediately instructed in how to induce the trance themselves and, thereby, achieve muscular relaxation and altered perception in the various organ systems. They were told to exercise three or four times per day for a few minutes. The 17 successful patients were interviewed for a total of from one to six times. Patients able to experience and induce the trance state also gained in self-confidence and optimism.
The prognostic spectrum of left main stenosis.
Authors: M J Conley, R L Ely, J Kisslo, K L Lee, J F McNeer, R A Rosati
Journal: Circulation (1978)

Three-year survival for 163 consecutive medically treated patients with 50% or greater left main stenosis was 50%. Survival was significantly higher for patients with 50 to 70% left main stenosis (one and three-year survivals of 91% and 66%) than for patients with 70% or greater left main stenosis (one and three-year survivals of 72% and 41%). In fact, left main lesions of less than 70% were not associated with the increased risk usually attributed to patients with left main stenosis. A number of noninvasive and catheterization characteristics were significant predictors of survival for patients with 70% or greater left main stenosis. Noninvasive descriptors defined a low risk subgroup (one and three-year survivals of 97% and 74%) and a high risk subgroup (one- and three-year survivals of 59% and 25%). These observations have important implications both in assessing therapeutic interventions and in managing individual patients.
Osteoarthritis of the hip and Heberden's nodes.
Authors: F McGoldrick, T M O'Brien
Journal: Annals of the Rheumatic Diseases (1989)

One hundred consecutive patients with proved osteoarthritis were assessed for the presence of terminal interphalangeal joint disease. There was a significant association found between the presence of Heberden's nodes and primary (axillary) arthritis. Secondary osteoarthritis was relatively free of nodal involvement. It is suggested that Heberden's nodes are a helpful clinical marker in differentiating between the two major groups of osteoarthritis.
The effects of dietary polyphenols on reproductive health and early development†
Authors: Christina Ly, Julien Yockell-Lelièvre, Zachary M. Ferraro, John T. Arnason, Jonathan Ferrier, Andrée Gruslin
Journal: Human Reproduction Update (2014)

BACKGROUNDEmerging evidence from clinical and epidemiological studies suggests that dietary polyphenols play an important role in the prevention of chronic diseases, including cancer, cardiovascular disease, diabetes and neurodegenerative disorders. Although these beneficial health claims are supported by experimental data for many subpopulation groups, some studies purport that excessive polyphenol consumption may have negative health effects in other subpopulations. The ever-growing interest and public awareness surrounding the potential benefits of natural health products and polyphenols, in addition to their widespread availability and accessibility through nutritional supplements and fortified foods, has led to increased consumption throughout gestation. Therefore, understanding the implications of polyphenol intake on obstetrical health outcomes is of utmost importance with respect to safe consumption during pregnancy.
GMC finds paediatrician guilty of abusing his position
Authors: Owen Dyer
Journal: BMJ (2004)

The General Medical Council ruled this week that the evidence against paediatrician David Southall was “not insufficient” to support a finding of serious professional misconduct, which in lay parlance amounts to a finding of guilt.

The council's professional conduct committee adjourned until August, when it will hear pleas in mitigation and decide whether or not to strike him off the medical register.

The case against Professor Southall of North Staffordshire Hospital centred on allegations that he accused a father of murdering his child solely on the basis of having seen the father interviewed in a television documentary.

Professor Dennis McDevitt, chairman of the GMC's professional conduct committee, said that Professor Southall had abused his position. The committee ruled that Professor Southall's actions were …
ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles
Authors: Anthony Renwick, Deborah Thompson, Sheila Seal, Patrick Kelly, Tasnim Chagtai, Munaza Ahmed, Bernard North, Hiran Jayatilake, Rita Barfoot, Katarina Spanova, Lesley McGuffog, D Gareth Evans, Diana Eccles, Douglas F Easton, Michael R Stratton, Nazneen Rahman
Journal: Nature Genetics (2006)
Inappropriate ubiquitin conjugation: a proposed mechanism contributing to heart failure
Authors: M Field
Journal: Cardiovascular Research (1997)

Ubiquitin; there is no doubt that ubiquitin is a "lucky" protein. It is lucky in many ways: lucky for scientific progress, lucky for biomedical scientists and lucky for life! If you have not already done so, why don't you get lucky and look for a role for ubiquitin in your experimental system. As Avram Hershko has said "there is plently to go around"! (Previousy quoted by Mayer et al. [1].)
Bone Density Testing in Older Women
Authors: Margaret L. Gourlay, John S. Preisser, Kristine E. Ensrud
Journal: JAMA (2012)

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