A NEW CONCEPT OF FAMILIAL ADENOMATOSIS
Authors: J D CARBALLO, R C GUMPEL
Journal: Annals of Internal Medicine (1956)

Article1 December 1956A NEW CONCEPT OF FAMILIAL ADENOMATOSISROY C. GUMPEL, M.D., JOSE D. CARBALLO, M.D.ROY C. GUMPEL, M.D.Search for more papers by this author, JOSE D. CARBALLO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-6-1045 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe disease familial adenomatosis has long been recognized, the first description being variously accredited to Menzel1 in 1721 and Virchow2 in 1863. It is characterized by a diffuse adenomatous involvement of the colon, a heredofamilial incidence and a close relationship to cancer of the large bowel. It is a distinct disease entity and is to be differentiated from postinflammatory polyposis and nonfamilial discrete polyps of the colon.Multiple sessile or pedunculated proliferations of the mucous membrane of the entire colon are found. Often there is a predilection for the terminal bowel and, rarely, the involvement is segmental. The stomach and...Bibliography1. Menzel , cited by Hewitt, J. H., and Howard, W. T.: Chronic ulcerative colitis with polyps, Arch. Int. Med. 15: 714, 1925. Google Scholar2. Virchow R: Die Krankhaften Geschwülste, 1863, Hirschwald, Berlin, 243. Google Scholar3. PollackSwinton JLNW: Congenital polyposis of the colon with extension to the small intestine and stomach, Lahey Clin. Bull. 9: 174-179, 1955. MedlineGoogle Scholar4. Cripps WH: Two cases of disseminated polyposis of the rectum, Trans. Path. Soc. London 33: 165, 1881. Google Scholar5. Gardner EJ: Am. J. Human Genet. 2: 41-48, 1950. MedlineGoogle Scholar6. Gardner EJ: A genetic and clinical study of intestinal polyposis, a predisposing factor for carcinoma of the colon and rectum, Am. J. Human Genet. 3: 167-176, 1951. MedlineGoogle Scholar7. GardnerPlenk EJHP: Hereditary pattern for multiple osteomas in a family group, Am. J. Human Genet. 4: 31-36, 1952. MedlineGoogle Scholar8. GardnerRichard EJRC: Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis, Am. J. Human Genet. 5: 139-147, 1953. MedlineGoogle Scholar9. Oldfield MC: The association of familial polyposis of the colon with multiple sebaceous cysts, Brit. J. Surg. 41: 534-541, 1954. CrossrefMedlineGoogle Scholar10. O'BrienWels JPP: The synchronous occurrence of benign fibrous tissue neoplasia in hereditary adenosis of the colon and rectum, New York State J. Med. 55: 1877-1880, 1955. MedlineGoogle Scholar11. WeinerCooper RSP: Multiple polyposis of the colon, osteomatosis, and soft tissue tumors, New England J. Med. 253: 795-799, 1955. CrossrefMedlineGoogle Scholar12. MillerSweet RHRH: Multiple polyposis of the colon, Ann. Surg. 105: 511-515, 1937. CrossrefMedlineGoogle Scholar13. PughNesselrod HLJP: Multiple polypoid disease of the colon and rectum, Ann. Surg. 121: 88, 1945. CrossrefMedlineGoogle Scholar14. Guptill P: Familial polyposis of the colon, two families, five cases, Surgery 22: 286-304, 1947. MedlineGoogle Scholar15 ClarkParker FBJM: Familial polyposis of the colon, J. Maine M. A. 41: 331-335, 1950. MedlineGoogle Scholar16. ScarboroughKlein RARR: Polypoid disease of the colon and rectum, Am. J. Surg. 76: 723-727, 1948. CrossrefMedlineGoogle Scholar17. DixonBenson CFRE: Total and subtotal colectomy with review of 72 cases, S. Clinic North America 26: 949, 1946. MedlineGoogle Scholar18. McKenney DC: Multiple polyposis, J. A. M. A. 107: 1871, 1936. CrossrefGoogle Scholar19. LeFevreJacques HWTF: Multiple polyposis in an infant of four months, Am. J. Surg. 81: 90-91, 1951. CrossrefMedlineGoogle Scholar20. McKenney DC: Multiple polyposis, Am. J. Surg. 46: 204, 1939. CrossrefGoogle Scholar21. Strode JE: Polyposis of the colon, Am. J. Surg. 50: 353, 1940. CrossrefGoogle Scholar22. Lockhart-Mummery JP: The causation and treatment of multiple polyposis of the colon, Ann. Surg. 99: 178, 1934. CrossrefMedlineGoogle Scholar23. Annotations: Polyposis of the colon with additional features, Lancet 1: 196, 1956. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication May 21, 1956.From the Medical Service, Veterans Administration Hospital, Coral Gables, Florida.Requests for reprints should be addressed to Roy C. Gumpel, M. D., 335 Rushmore Avenue, Mamaroneck, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFamilial polyposis of the colon. 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