Lymphocytic Subsets in the Acquired Immunodeficiency Syndrome
Authors: SUDHIR GUPTA
Journal: Annals of Internal Medicine (1983)

Letters and Corrections1 October 1983Lymphocytic Subsets in the Acquired Immunodeficiency SyndromeSUDHIR GUPTA, M.D., KENRICK LICORISH, M.D., GARY GARTHFIELD, M.D.SUDHIR GUPTA, M.D.Search for more papers by this author, KENRICK LICORISH, M.D.Search for more papers by this author, GARY GARTHFIELD, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-4-566_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A number of immune defects, predominantly those associated with T-cell immunity leading to increased susceptibility to opportunistic infections and increased incidence of Kaposi's sarcoma have been found in the blood of homosexual men with the acquired immunodeficiency syndrome (1-2). We report a study of monoclonal antibody-defined subpopulations of T cells and natural killer cells, and the proliferative response to mitogens in the peripheral and lymph nodes of a 26-year-old homosexual man with the syndrome who died of pneumocystis pneumonia.Mononuclear cells from the heparinized peripheral blood were separated on Ficoll-Hypaque gradient. Lymph nodes were teased and cell...References1. GOTTLIEBSCHROFFSHANKER MRH. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new cellular acquired immunodeficiency. N Engl J Med. 1981;305:1425-30. CrossrefMedlineGoogle Scholar2. URMACHERMYSOKOWSKIPOHOA CCM. Outbreak of Kaposi's sarcoma with cytomegalovirus infection in young homosexual men. Am J Med. 1982;72:569-75. CrossrefMedlineGoogle Scholar3. ABOBALCH TC. A differentiation antigen on human NK and K cells identified by monoclonal antibody (HNK-1). J Immunol. 1981;127:1024-29. MedlineGoogle Scholar4. RODERPROSS RH. The biology of human natural killer cells. J Clin Immunol. 1982;2:249-63. CrossrefMedlineGoogle Scholar5. ANTONELLISTEWARTDUPONT PWB. Distribution of natural killer cell activity in peripheral blood, cord blood, thymus, lymph nodes and spleen and the effect of in vitro treatment with interferon preparation. Clin Immnol Immunopath. 1981;19:161-9. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SUDHIR GUPTA, M.D.; KENRICK LICORISH, M.D.; GARY GARTHFIELD, M.D.Affiliations: University of California Irvine, CA 92717 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLymphocyte subsets as surrogate markers in antiretroviral therapyExpansion of activated T lymphocytes (CD3+HLA/DR+) detectable in early stages of HIV-1 infectionAbnormality of Leu 2+7+ cells in acquired immune deficiency syndrome (AIDS), AIDS-related complex, and asymptomatic homosexuals 1 October 1983Volume 99, Issue 4Page: 566-567KeywordsAIDSCellsHomosexualsKaposi sarcomaLymph nodesNatural killer cellsOpportunistic infectionsPneumocystisPneumoniaT cells ePublished: 1 December 2008 Issue Published: 1 October 1983 PDF downloadLoading ...