tbuckley/cabot-search huggingface dataset:
AIDS awareness campaign that used Hitler lookalike provokes anger and support
Authors: N. Stafford
Journal: BMJ (2009)

A video advertisement made in Germany depicting a naked and grinning Adolf Hitler having sex with a woman has been strongly criticised around the world by many—but not all—experts on HIV and AIDS as the wrong approach to increase awareness of the disease.

The video and accompanying print advertisements and posters, which also feature the dictators Saddam Hussein and Joseph Stalin, carry the slogan: “AIDS is a mass murderer.” The campaign was commissioned by Regenbogen, an AIDS awareness group that believes that public concern about HIV and AIDS is diminishing, even while the number of infections and deaths continues to rise. 

On the campaign website Regenbogen, whose name means rainbow, explains: “The campaign is designed to shake people up, to bring the topic of AIDS back to centre stage, and to reverse the trend of unprotected sexual intercourse.”

The 45 second video begins with an unidentifiable man and woman entering a dimly lit apartment and beginning to fondle each other. They …
Cardiac and Skeletal Muscle Myoglobin Release After Reperfusion of Injured Myocardium in Dogs With Systemic Hypotension
Authors: Edward J. Spangenthal, Avery K. Ellis
Journal: Circulation (1995)

Background Myoglobin (Mb) is an intramyocardial protein that is released into the systemic circulation and rapidly cleared via the kidneys after myocardial injury. Arterial Mb concentration–time curves have been studied in humans and dogs in the setting of acute coronary artery occlusion, and the rate of rise of Mb is both sensitive and specific as an indicator of successful coronary artery reperfusion. Systemic hypotension may alter Mb kinetics and impact on the utility of this method by causing Mb release from ischemic skeletal muscle and by decreasing renal Mb clearance. This study was undertaken to determine whether analysis of Mb kinetics remains accurate in identifying coronary reperfusion in the setting of systemic hypotension. Methods and Results Eighteen chronically instrumented dogs were made hypotensive by being bled via a large-bore femoral artery catheter into a reservoir adjusted to maintain a constant mean arterial pressure of 50 mm Hg for 8 hours. After the first hour of hypotension, each dog was studied under one of the following three protocols: group 1, 2 hours of mid–left anterior descending artery (LAD) occlusion followed by 5 hours of unlimited reperfusion; group 2, 7 hours of mid-LAD occlusion without reperfusion; or group 3, 7 additional hours of hypotension alone. Systemic lactate extractions demonstrated a shift to anaerobic metabolism in skeletal muscle and confirmed that shock was established in all animals. Regional arteriovenous Mb differences in group 1 animals demonstrated release of large amounts of Mb from reperfused myocardium; in contrast, smaller amounts of Mb were released both from skeletal muscle rendered ischemic by hypotension and from myocardium rendered ischemic by coronary occlusion without reperfusion. In group 1 dogs, arterial Mb rose rapidly immediately after reperfusion, with peak Mb occurring 108±24 minutes (mean±SEM) after vessel reopening. In group 2 and group 3 dogs, arterial Mb rose more slowly, such that peak Mb was not reached within 8 hours in 11 of 12 animals. The linear rate of rise of arterial Mb over the first hour of reperfusion in group 1 dogs was 51±16 ng · mL −1 · min −1 . This slope was significantly greater than slopes determined over the same time period in dogs occluded and not reperfused (group 2, 1.2±0.6 ng · mL −1 · min −1 ) and in those hypotensive alone (group 3, 0.8±0.5 ng · mL −1 · min −1 ). All the slopes of group 2 and group 3 dogs fell below the range of slopes of group 1 dogs. In contrast to slopes of the Mb concentration–time curves, linear creatine kinase slopes were significantly less sensitive in predicting reperfusion. Conclusions Analysis of plasma Mb kinetics allows early identification of coronary reperfusion after myocardial injury even in the presence of significant systemic hypotension.
Four Chamber FDG Uptake in the Heart
Authors: Ana M. Franceschi, Robert Matthews, Seth Mankes, Elham Safaie, Dinko Franceschi
Journal: Clinical Nuclear Medicine (2012)

A 57-year-old-male presented for whole-body PET with CT for restaging of lung cancer. Besides revealing postradiation changes, we noticed an unusual pattern of FDG uptake in the myocardium, with prominent metabolic uptake involving 4 chambers of the heart. Later that day, the patient was referred to the emergency department for increased heart rate, but otherwise asymptomatic. CT angiography was performed, which showed scattered filling defects in bilateral pulmonary arteries consistent with pulmonary embolism. The finding of prominent FDG uptake involving all cardiac chambers in this patient is likely related to heart strain caused by acute pulmonary embolism.
Split ileostomy and ileocolostomy for Crohn's disease of the colon and ulcerative colitis: a 20 year survey.
Authors: P H Harper, S C Truelove, E C Lee, M G Kettlewell, D P Jewell
Journal: Gut (1983)

The clinical course of 140 patients who have had a split ileostomy for ulcerative colitis or colonic Crohn9s disease over a 20 year period is reported. In 37 patients with ulcerative colitis there was no sustained improvement. In the 102 patients with Crohn9s disease there was an immediate clinical improvement in 95, which was sustained in 65. Thirty patients have subsequently required a proctocolectomy for persistent inflammation, and 28 are still defunctioned. Bowel continuity was restored after 61 split ileostomies and in 44 patients intestinal continuity remains intact at the present time (mean follow up since closure = 62.5 months, range 0-231 months). It is concluded that a split ileostomy is a safe conservative operation producing at least temporary improvement in severely ill and malnourished patients with Crohn9s colitis, and that if a subsequent resection becomes necessary it may be less extensive than was thought applicable at the initial operation. In 27 patients a resection has not been required.
Effects of fenofibrate on high-fat diet-induced body weight gain and adiposity in female C57BL/6J mice
Authors: Sunhyo Jeong, Miyoung Han, Hyunghee Lee, Mina Kim, Jaekwang Kim, Christopher J. Nicol, Bang Hyun Kim, Jae Hoon Choi, Ki-Hoan Nam, Goo Taeg Oh, Michung Yoon
Journal: Metabolism (2004)
SHOE-DYE POISONING: REPORT OF A CASE IN AN EIGHT MONTHS OLD INFANT
Authors: Samuel J. Levin
Journal: JAMA (1931)

Shoe-dye poisoning is relatively uncommon in children. Riviere 1 reported eleven cases of cyanosis in children 1½ to 10 years of age following the dyeing of shoes with a dye containing aniline. Muehlberger 2 reported two cases in children of 3½ and 6 years of age. Ullmann 3 has called attention to the fact that children are especially susceptible to shoe-dye poisoning. Recently I reported a case of shoe-dye poisoning in a child of 2 years, at that time the youngest patient in the American literature. 4 The following case in an 8 months old infant is, I believe, the youngest reported case of this interesting condition.  D. C., a girl, aged 8 months, white, was admitted to the Children's Hospital, Sept. 3, 1928, because of fainting and turning blue. She had had a full term, normal delivery, with no cyanosis or convulsions. She had been breast fed for six
More on copying letters to patients: Use of letters in the consulting process still seems Victorian
Authors: P. A West
Journal: BMJ (2003)

<h3>Abstract</h3> The spread of the COVID-19 pandemic, effected the imposition of personal protection measures in a large number of countries. The use of commercially available personal face masks was widely accepted as such a protective measure. Since the quality of the face masks scanned the spectrum from surgical to the home made fabric ones, it was considered appropriate to experimentally establish their effectiveness for stopping aerosol in entering the respiratory system of the bearer. Presently, only eight masks were tested with polydisperse indoor air. Their effectiveness was examined for aerosol of aerodynamic diameters of 0.006 μm to 10 μm. Of these masks, only two were effective for the whole range of aerosol. Cloth masks were found to be ineffective for the assigned task.
Glycemia and Immune Responses
Authors: V W ADAMKIEWICZ
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anger, Depression and Personality Dimensions in Patients with Migraine without Aura
Authors: Giovanni Abbate-Daga, Secondo Fassino, Rossana Lo Giudice, Innocenzo Rainero, Carla Gramaglia, Lucrezia Marech, Federico Amianto, Salvatore Gentile, Lorenzo Pinessi
Journal: Psychotherapy and Psychosomatics (2007)

Migraine without aura causes acute and chronic pain and partially compromises patients' social functioning and work performance. Over the past years, psychiatric comorbidities were frequently observed in these patients, together with coping difficulties and typical personality traits. The aim of this study was to identify whether migraine patients and controls share distinctive personality traits.105 consecutive patients suffering from migraine without aura referred to the Headache Center of Turin University were enrolled in the study and compared to a control group of 79 healthy subjects. Patients and controls completed several psychometric questionnaires, including the Temperament and Character Inventory, the Beck Depression Inventory and the State-Trait Anger Expression Inventory.Patients suffering from migraine show more depressive symptoms, difficult anger management with a tendency to hypercontrol, and a distinctive personality profile with high harm avoidance, high persistence and low self-directedness. When a logistic regression was performed, the only significant predictors of migraine were temperament variables.The results suggest that the personality traits and psychosomatic mechanisms of migraine patients may make them vulnerable to stress and less skilled in coping with pain. These traits correlate with dysregulated neurotransmitter systems which may also be part of the psychobiological components of personality, depressive disorders and migraine itself.
Discordant Manifestations of Hepatitis C in Monozygotic Twins
Authors: Sandro Vento, Lorenza Guella, Ercole Concia
Journal: New England Journal of Medicine (1995)

To the Editor: The clinical manifestations and evolution of hepatitis C virus (HCV) infection are thought to be influenced by the viral genotype and by the immunoreactivity of the infected person.1...
DPC4 gene mutation in colitis associated neoplasia.
Authors: A T Hoque, S A Hahn, M Schutte, S E Kern
Journal: Gut (1997)

BACKGROUND: Colitis associated dysplasia and cancer often have deletions involving the long arm of chromosome 18q, suggesting the location of a tumour suppressor gene critical for their tumorigenesis. The DPC4 gene, which is genetically inactivated in pancreatic and other cancers, has recently been described. AIM: Because DPC4 is located at 18q21.1, the hypothesis that it could be a mutated tumour suppressor gene in colitis associated neoplasms was tested. PATIENTS: Advanced neoplastic lesions from six patients having chronic colitis were analysed for DPC4. METHODS: Individual exons of DPC4 were amplified by the polymerase chain reaction (PCR) and sequenced from genomic DNA of tissue specimens dissected by cryostat. RESULTS: DPC4 was found to have biallelic inactivation in one of three neoplasms shown to have allelic loss of 18q. The mutation had been acquired somatically in a plaque of high grade dysplasia. The mutation created a non-sense codon, which would cause premature termination of protein translation. CONCLUSION: The DPC4 gene is a target of 18q LOH events in colitis associated neoplasia.
Phenotypic Improvement of Dystrophic Muscles by rAAV/Microdystrophin Vectors Is Augmented by Igf1 Codelivery
Authors: Simone Abmayr, Paul Gregorevic, James M. Allen, Jeffrey S. Chamberlain
Journal: Molecular Therapy (2005)

The absence of dystrophin in Duchenne muscular dystrophy (DMD) leads to sarcolemmal instability and enhances the susceptibility of muscle fibers to contraction-induced injury. Various viral vectors have been used to deliver mini- and microdystrophin expression cassettes to muscles of dystrophin-deficient mdx mice, significantly increasing both the morphological and the functional properties of the muscles. However, dystrophin delivery to adult mdx mice has not yielded a complete rescue of the dystrophic phenotype. Here we investigated a novel strategy involving dual gene transfer of recombinant adeno-associated viral vectors expressing either microdystrophin (rAAV-μDys) or a muscle-specific isoform of Igf-1 (rAAV-mIgf-1). Injection of mdx muscles with rAAV-μDys reduced myofiber degeneration and turnover and increased their resistance to mechanical injury, but did not increase muscle mass or force generation. Injection of mdx muscles with rAAV-mIgf-1 led to increased muscle mass, but did not provide protection against mechanical injury or halt myofiber degeneration, leading to loss of the vector over time. In contrast, co-injection of the rAAV-μDys and rAAV-mIgf-1 vectors resulted in increased muscle mass and strength, reduced myofiber degeneration, and increased protection against contraction-induced injury. These results suggest that a dual-gene, combinatorial strategy could enhance the efficacy of gene therapy of DMD.
Homozygosity for a HERG potassium channel mutation causes a severe form of long QT syndrome: identification of an apparent founder mutation in the Finns
Authors: Kirsi Piippo, Päivi Laitinen, Heikki Swan, Lauri Toivonen, Matti Viitasalo, Michael Pasternack, Kristian Paavonen, Hugh Chapman, Kenneth T. Wann, Eeva Hirvelä, Antti Sajantila, Kimmo Kontula
Journal: Journal of the American College of Cardiology (2000)
Is severe bradycardia in veteran athletes an indication for a permanent pacemaker?
Authors: R. J. Northcote, A. C. Rankin, R. Scullion, W. Logan
Journal: BMJ (1989)

morphologically and with the help of immunocyto- chemistry.There was no staining by antibodies CK 1 (Dako) or CAM 5.2 (Becton-Dickinson) to intra- cellular cytokeratin antigens.All the tumours stained positively for vimentin but not for desmin or leucocyte common antigen.The main differential diagnosis of spindle cell squamous carcinoma was excluded in each case.1
Mammon and Medicine: The Rewards of Clinical Trials-Reply
Authors: Steven Lipper
Journal: JAMA (1986)

<h3>In Reply.—</h3> We regret that our concern for what we believe to be truly informed consent and a patient's freedom to decide about participation in clinical trials has been misinterpreted by Dr Jaffe as a reflection of "over-whelming cynicism." Dr Jaffe does "not disagree... that patients should know if the physician is receiving a special bounty for enrolling them in clinical trials." He apparently believes, however, that "special bounties" are not of great size and are seldom paid. Our professional experiences are similar to those described by Dr Spiro, who is concerned in his important commentary with the "irresistible" opportunity to complete a study in which considerable or lesser sums are paid for each subject. Along with Dr Spiro, we "do not suggest that such payment for completion of... important studies is wrong, dishonest, or immoral. But letting the patient know that we are earning money on his body, that
The CDC and Abortion in HIV-Positive Women-Reply
Authors: David A. Grimes
Journal: JAMA (1988)

<h3>In Reply.</h3> —Dr Gunn's Letter diverts attention from the CDC's suppression of abortion information by raising two specious issues. First, he argues that no "committee" was assembled in 1985 to develop guidelines. While he is correct that the group of consultants assembled in Atlanta in October 1985 did not constitute a "committee" (a semantic nuance that is lost on those who are unfamiliar with the bureaucracy), a CDC committee was already at work by the time Dr Gunn became involved (memorandum, Richard M. Selick, MD, to James A. Curran, MD, Oct 3, 1985). Then a commissioned officer at the CDC, I was involved with both the committee and the consultants. Second, Dr Gunn alleges that there was vigorous objection to the mention of elective abortion. Louise B. Tyrer, MD, a representative from the Planned Parenthood Federation of America, recommended that HIV-infected pregnant women be counseled about the option of abortion.
Global patterns of cis variation in human cells revealed by high-density allelic expression analysis
Authors: Bing Ge, Dmitry K Pokholok, Tony Kwan, Elin Grundberg, Lisanne Morcos, Dominique J Verlaan, Jennie Le, Vonda Koka, Kevin C L Lam, Vincent Gagné, Joana Dias, Rose Hoberman, Alexandre Montpetit, Marie-Michele Joly, Edward J Harvey, Daniel Sinnett, Patrick Beaulieu, Robert Hamon, Alexandru Graziani, Ken Dewar, Eef Harmsen, Jacek Majewski, Harald H H Göring, Anna K Naumova, Mathieu Blanchette, Kevin L Gunderson, Tomi Pastinen
Journal: Nature Genetics (2009)
Dilated pupils caused by topical glycopyrrolate for hyperhidrosis
Authors: K.J. Panting, A.S. Alkali, W.D. Newman, G.R. Sharpe
Journal: British Journal of Dermatology (2007)

Journal Article Dilated pupils caused by topical glycopyrrolate for hyperhidrosis Get access K.J. Panting, K.J. Panting Departments of Dermatology and Paediatric Ophthalmology, Royal Liverpool Children's Hospital, Alder Hey, Eaton Road, Liverpool L12 2AP, U.K. E‐mail: kath.panting@rlbuht.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar A.S. Alkali, A.S. Alkali Departments of Dermatology and Paediatric Ophthalmology, Royal Liverpool Children's Hospital, Alder Hey, Eaton Road, Liverpool L12 2AP, U.K. E‐mail: kath.panting@rlbuht.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar W.D. Newman, W.D. Newman Departments of Dermatology and Paediatric Ophthalmology, Royal Liverpool Children's Hospital, Alder Hey, Eaton Road, Liverpool L12 2AP, U.K. E‐mail: kath.panting@rlbuht.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar G.R. Sharpe G.R. Sharpe Departments of Dermatology and Paediatric Ophthalmology, Royal Liverpool Children's Hospital, Alder Hey, Eaton Road, Liverpool L12 2AP, U.K. E‐mail: kath.panting@rlbuht.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 158, Issue 1, 1 January 2008, Pages 187–188, https://doi.org/10.1111/j.1365-2133.2007.08261.x Published: 01 January 2008
Human lymphocyte complement receptors. Quantitative requirements for C3 of normal and chronic lymphocyte leukemia lymphocytes.
Authors: G L Logue, H J Cohen
Journal: Journal of Clinical Investigation (1977)

Erythrocytes coated with varying amounts of human complement were used to detect lymphocytes with complement receptors from normal subjects and patients with chronic lymphocytic leukemia. The relationship between the percentage of lymphocytes rosetting and the quantity of C3 present on complement-coated erythrocytes were studied. Small quantities of C3 (less than 5 fg/erythrocyte) caused maximal rosetting of normal lymphocytes. Maximal rosetting with chronic lymphocytic leukemia lymphocytes was not reached until much greater amounts of C3 were used to coat the erythrocytes. This difference in sensitivity to erythrocyte-bound complement was not due to an increased fraction of complement receptor-bearing cells in the leukemic patients. This loss of sensitivity of the chronic lymphocytic leukemia lymphocyte for complement may play a role in the immune deficiency present in this disease.
Neurologic Complications of Cancer, 2nd ed.
Authors: Lisa R. Rogers
Journal: Neuro-Oncology (2009)

The second edition of Neurologic Complications of Cancer is an extensively updated and revised version of the 1995 text authored by Jerome B. Posner.The chapters detailing the pathophysiology and treatment of central nervous system (CNS) and peripheral nervous system (PNS) metastasis and the neurologic complications of cancer treatment are the most extensively revised.As in the original, there are three main sections, the first of which is an overview of the general principles of neuro-oncology, including a classification of neurooncologic disorders and an approach to the evaluation of the patient with a proven or suspected neuro-oncologic disorder.Chapter 2, Pathophysiology of Nervous System Metastases, is updated and revised to reflect the recent and ongoing exploration of the mechanisms of metastasis to the CNS and PNS.This detailed review of laboratory and clinical features of nervous system metastasis is important because of the increasing recognition that certain tumors have a high propensity to spread to the CNS, whether it be due to an inherent property of the cancer ("seed hypothesis") or of the nervous system tissue, which provides the substrate to attract and allow attachment and growth of the cancer ("soil hypothesis").In Chapter 3, the anatomy and physiology of the blood-brain and blood-cerebrospinal fluid barriers are outlined, with detailed information regarding drug delivery across the barriers.Disruption of the bloodbrain barrier, with resulting vasogenic edema, is a common complication of brain metastasis, and attention is focused on the variety of clinical symptoms and signs by which vasogenic edema presents and on the management of this consequence.The last chapter of this section provides useful information on symptom management, as well as valuable information on drug interactions, including antimicrobials and chemotherapy.Of particular value to the non-neurologist is a detailed approach to the management of seizures, including status epilepticus, in the cancer patient.The second section details the clinical aspects of metastasis to the CNS and PNS.Each subsection includes an overview of the frequency, pathophysiology, Neurologic Complications of Cancer, 2nd ed.Contemporary Neurology Series.
969 CHARACTERIZATION OF A SERIES OF HIGHLY POTENT PHOSPHORAMIDATE NUCLEOSIDE ANALOGUE INHIBITORS OF HEPATITIS C POLYMERASE
Authors: J. Vernachio, S. Chamberlain, C. Chang, B. Ganguly, E. Gorovits, A. Hall, G. Henson, J. Hutchins, A. Kolykhalov, Y. Liu, J. Muhammad, A. Gilles, S. Holl, K. Madela, C. Mc Guigan, J. Patti
Journal: Journal of Hepatology (2009)