EFFECTS OF NITROGEN MUSTARD ON THE BONE MARROW IN POLYCYTHEMIA VERA
Authors: C C SHULLENBERGER, C H WATKINS
Journal: Annals of Internal Medicine (1950)

Article1 October 1950EFFECTS OF NITROGEN MUSTARD ON THE BONE MARROW IN POLYCYTHEMIA VERAC. C. SHULLENBERGER, M.D., CHARLES H. WATKINS, M.D., F.A.C.P.C. C. SHULLENBERGER, M.D.Search for more papers by this author, CHARLES H. WATKINS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-33-4-841 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince there is as yet no knowledge of the cause of the increased rate of erythrocyte production in polycythemia vera, the most desirable therapeutic agent for this disease, from a theoretical standpoint, is one which can be given in dosage sufficient to depress the abnormal rate of mitosis in the erythropoietic tissue without seriously affecting the bone marrow cells which give rise to the granulocytes and platelets. At present, it is believed that the agent which most nearly fulfills these criteria is irradiation, by means either of roentgen-rays or of radioactive phosphorus. Recently, however, nitrogen mustard has received attention as...Bibliography1. Rhoads CP: Nitrogen mustards in the treatment of neoplastic disease, J. A. M. A. 131: 656-658, 1946. CrossrefMedlineGoogle Scholar2. JacobsonSpurrBarronSmithLushbaughDick LOCLESTCGF: Nitrogen mustard therapy; studies on the effect of methyl-bis (beta-chloroethyl) amine hydrochloride on neoplastic diseases and allied disorders of the hemopoietic system, J. A. M. A. 132: 263-271, 1946. CrossrefMedlineGoogle Scholar3. FriedenwaldBuschkeScholzMoses JSWROSG: Some effects of sulfur and nitrogen mustards on cell nuclei in mammalian cornea, In American Association for the Advancement of Science: Approaches to Tumor Chemotherapy, 1947, 358-378. Google Scholar4. CannanLevyBenagliaVislocky RKMAK: Quoted by Gilman, Alfred, and Philips, F. S.: The biological actions and therapeutic applications of the β-chloroethyl amines and sulfides, Science 103: 409-415, 436, 1946. CrossrefGoogle Scholar5. Schleicher EM: Staining aspirated human bone marrow with domestic Wright stain, Stain Technol. 17: 161-164, 1942. CrossrefGoogle Scholar6. TinneyHallGiffin WSBEHZ: The prognosis of polycythemia vera, Proc. Staff Meet., Mayo Clin. 20: 306-310, 1945. Google Scholar7. Wintrobe MM: Clinical hematology, Philadelphia, Lea & Febiger, 1946, p. 595. Google Scholar8. OsgoodSeaman EEAJ: The cellular composition of normal bone marrow as obtained by sternal puncture, Physiol. Rev. 24: 46-69, 1944. CrossrefGoogle Scholar9. Japa J: A study of the mitotic activity of normal human bone marrow, Brit. J. Exper. Path. 23: 272-276, 1942. Google Scholar10. KarnofskyBurchenalOrmsbeeCornmanRhoads DAJHRAICP: Experimental observations on the use of the nitrogen mustards in the treatment of neoplastic disease, In American Association for the Advancement of Science: Approaches to Tumor Chemotherapy, 1947, 293-305. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication October 23, 1948.†Fellow in Medicine, Mayo Foundation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPolycythemia vera: historical oversights, diagnostic details, and therapeutic viewsMyeloproliferative neoplasms: A decade of discoveries and treatment advancesThe history of myeloproliferative disorders: before and after DameshekPolycythemiaDer heutige Stand der Chemotherapie neoplastischer Erkrankungen beim MenschenBehandlung der Polycythaemia vera mit DaraprimTriethylenemelamine in polycythemia vera. A therapeutic trialChemical composition of bone marrow after exposure of rabbits to nitrogen mustard 1 October 1950Volume 33, Issue 4Page: 841-853KeywordsBone marrowBone marrow cellsGranulocytesPhosphorusPlateletsPolycythemia vera ePublished: 1 December 2008 Issue Published: 1 October 1950 PDF downloadLoading ...