Epinephrine and Outcome after Cardiac Arrest
Authors: Fritz Sterz
Journal: Annals of Internal Medicine (1999)

Letters1 June 1999Epinephrine and Outcome after Cardiac ArrestFritz Sterz, MD, Wilhelm Behringer, MD, and Harald Kittler, MDFritz Sterz, MDVienna General Hospital; 1090 Vienna, Austria (Sterz)Vienna General Hospital; 1090 Vienna, Austria (Behringer)Vienna General Hospital; 1090 Vienna, Austria (Kittler)Search for more papers by this author, Wilhelm Behringer, MDVienna General Hospital; 1090 Vienna, Austria (Sterz)Vienna General Hospital; 1090 Vienna, Austria (Behringer)Vienna General Hospital; 1090 Vienna, Austria (Kittler)Search for more papers by this author, and Harald Kittler, MDVienna General Hospital; 1090 Vienna, Austria (Sterz)Vienna General Hospital; 1090 Vienna, Austria (Behringer)Vienna General Hospital; 1090 Vienna, Austria (Kittler)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-130-11-199906010-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank the correspondents for their valuable comments about our concerns that an increasing cumulative epinephrine dose during resuscitation is independently associated with unfavorable neurologic outcome after ventricular fibrillation cardiac arrest.Although caution must be exercised in generalizing our results, they are important because they are the first to call into question the limit of subsequent epinephrine doses (1). Resuscitation researchers are well aware of the limitations in their study designs and the many other difficulties involved in conducting clinical studies. However, no better methods to overcome these handicaps, other than using an internationally recognized protocol (1), have ...References1. Cummins RO, Hazinski MF. The next chapter in the high-dose epinephrine story: unfavorable neurologic outcomes? [Editorial]. Ann Intern Med. 1998;129:501-2. LinkGoogle Scholar2. Gueugniaud PY, Mols P, Goldstein P, Pham E, Dubien PY, Deweerat C, et al . A comparison of repeated high doses and repeated standard doses of epinephrine for cardiac arrest outside the hospital. European Epinephrine Study Group. N Engl J Med. 1998;339:1595-601. CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Vienna General Hospital; 1090 Vienna, Austria (Sterz)Vienna General Hospital; 1090 Vienna, Austria (Behringer)Vienna General Hospital; 1090 Vienna, Austria (Kittler) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCumulative Epinephrine Dose during Cardiopulmonary Resuscitation and Neurologic Outcome Wilhelm Behringer , Harald Kittler , Fritz Sterz , Hans Domanovits , Waltraud Schoerkhuber , Michael Holzer , Marcus Mullner , and Anton N. Laggner Electronic Patient–Physician Communication Kenneth D. Mandl and Isaac S. Kohane Venlaxafine-Associated Hepatitis Yves Horsmans , Michel De Clercq , and Christine Sempoux Metrics 1 June 1999Volume 130, Issue 11Page: 942-943KeywordsAmbulancesCohort studiesEpinephrineHeartInterquartile rangeResuscitationVentricular fibrillation Issue Published: 1 June 1999 CopyrightCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...