Osteoporosis: A Review of Pathogenesis and Treatment
Authors: JACOB BASSAN
Journal: Annals of Internal Medicine (1963)

Review1 March 1963Osteoporosis: A Review of Pathogenesis and TreatmentJACOB BASSAN, M.D., BOY FRAME, M.D., F.A.C.P., HAROLD FROST, M.D.JACOB BASSAN, M.D.Search for more papers by this author, BOY FRAME, M.D., F.A.C.P.Search for more papers by this author, HAROLD FROST, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-3-539 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOsteoporosis is a generic term used to designate a metabolic bone disorder characterized by a decrease in bone mass with normal mineral content. It occurs as a result of varied pathogenic mechanisms and is associated with a number of different disease processes.Osteoporosis was first described by Pommer in 1885 (1). Though little was then known about its incidence and etiology, Pommer thought that the condition was the result of decreased bone formation, while bone resorption remained normal (2). Dietary deficiency of calcium was initially considered the major etiological factor, thus most patients were treated with calcium supplements and vitamin...References1. POMMER G: Rachitis and Osteomalacie, F. C. W. Vogel, Leipzig, 1885. Google Scholar2. POMMER G: Über Osteoporose, ihren Urspung und ihre Diffential Diagnostiche Redeutung. Arch. Klin. Chir. 136: 1, 1925. Google Scholar3. ADAMSBOOTHBYSNELL MWMAM: Metabolic studies in osteoporosis. J. Clin. Invest. 7: 75, 1929. MedlineGoogle Scholar4. BAUERMARBLE WA: Studies on the mode of action of irradiated ergosterol. J. Clin. Invest. 11: 21, 1932. CrossrefMedlineGoogle Scholar5. MEULENGRACHT E: Osteomalacia of the spinal column from deficient diet or from disease of the digestive tract. Acta Med. Scand. 101: 138, 1939. CrossrefGoogle Scholar6. 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THOMSON, M.D., BOY FRAME, M.D., F.A.C.P.Allgemeine Radiologie und Morphologie der KnochenkrankheitenComparative Physiology of BoneOsteoporotic bone loss in two prehistoric Indian populationsThe Antiquity of Age-Associated Bone Demineralization in ManTHE ONSET OF POSTMENOPAUSAL OSTEOPOROSIS AS STUDIED BY A NEW TECHNIQUEEffects of androgens, estrogens and high calcium intakes on bone formation and resorption in osteoporosis 1 March 1963Volume 58, Issue 3Page: 539-550KeywordsBone densityCalciumEtiologyHormonal therapyHormonesMalnutritionOsteoporosisPathogenesisPathogensProteins Issue Published: 1 March 1963 PDF downloadLoading ...