DRUG IDIOSYNCRASY, WITH SPECIAL REFERENCE TO AMIDOPYRINE, AS A CAUSE OF AGRANULOCYTIC ANGINA
Authors: Thomas Fitz-Hugh
Journal: Annals of Internal Medicine (1934)

Article1 August 1934DRUG IDIOSYNCRASY, WITH SPECIAL REFERENCE TO AMIDOPYRINE, AS A CAUSE OF AGRANULOCYTIC ANGINATHOMAS FITZ-HUGH JR., A.M., M.D., F.A.C.P.THOMAS FITZ-HUGH JR., A.M., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-2-148 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe designation, agranulocytic angina, although etymologically incorrect and scientifically inept, has become firmly entrenched—despite other preferable designations such as "pernicious leukopenia" or "primary granulocytopenia." It is here employed, in the now generally accepted sense, as designating the syndrome of Schultz. This disorder was at first viewed as a peculiar reaction to some unknown infection, analogous to the previously recognized leukopenia sometimes encountered in overwhelming sepsis. Soon, however, it became clear that the heterogeneous microorganismal invasion, seen in the majority of cases of agranulocytic angina, is merely a secondary or terminal event and is preceded by profound neutropenia. This led to...Bibliography1. BABBITTFITZ-HUGH JAT: Agranulocytic angina; report of a case with apparent recovery, Arch. Otolaryng., 1930, xii, 439-445. (Discussion by Dr. O. H. P. Pepper.) CrossrefGoogle Scholar2. PEPPER OH: Leukopenia: a review with special reference to agranulocytic angina, Calif. and West. Med., 1931, xxxv, 173. Google Scholar3. FITZ-HUGHCOMROE TBI: Agranulocytic angina (pernicious leukopenia), Am. Jr. Med. Sci., 1933, clxxxv, 552-561. (See footnote to table 4.) CrossrefGoogle Scholar4. MADISONSQUIER FWTL: The etiology of primary granulocytopenia (agranulocytic angina), Jr. Am. Med. Assoc., 1934, cii, 755-759. CrossrefGoogle Scholar5. WATKINS C: The possible rôle of barbiturates and amidopyrine in causation of leukopenic states, Proc. Staff Meet. 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Saunders Co., Philadelphia, p. 343-351. Google Scholar20. SHAYRAVDINFITZ-HUGH HIST: The use of sodium dehydrocholate (decholin-sodium) in the treatment of certain allergic diseases. (Read May 28, 1934, before the College of Physicians of Philadelphia.) Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication June 23, 1934.From the Department of Medicine, Hospital of the University of Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Role of Leukocyte-Generated Reactive Metabolites in the Pathogenesis of Ideosyncratic Drug ReactionsTierexperimentelle Untersuchungen zur medikamentös-allergischen Agranulocytose SchultzBlood Dyscrasias As Related to Periodontal Disease: With Special Reference to LeukemiaBlood dyscrasias from a dental point of viewDiscussion on AgranulocytosisAgranulocytosis: A Critical Review of Causes and Treatment, Historical and General**From the Department of Pharmacology, Stanford University School of Medicine. 1 August 1934Volume 8, Issue 2Page: 148-155KeywordsAnginaDrugsHospital medicineNeutropeniaSepsis ePublished: 1 December 2008 Issue Published: 1 August 1934 PDF downloadLoading ...