Chronicity of Epstein-Barr Virus Infection
Authors: JAMES C. NIEDERMAN
Journal: Annals of Internal Medicine (1985)

Editorials1 January 1985Chronicity of Epstein-Barr Virus InfectionJAMES C. NIEDERMAN, M.D.JAMES C. NIEDERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-1-119 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMultiple lines of investigation using serologic, virologic, and immunologic techniques have solidly established that infectious mononucleosis results from a primary infection with Epstein-Barr virus (1-8). A fundamental property of this agent, a member of the herpesvirus group, is its tropism for B lymphocytes of the human host and its unique ability to induce continuous growth of lymphocytes in cell culture (immortalization) (9). In mononucleosis, a characteristic polyclonal B-cell proliferative response is induced.One striking manifestation of lymphoproliferation in infectious mononucleosis is the presence of large numbers of atypical lymphocytes in peripheral blood. Relatively few lymphocytes are actually infected by Epstein-Barr...References1. HENLE G, HENLE W, and DIEHL V. Relation of Burkitt's tumor-associated herpes-type virus to infectious mononucleosis. Proc Natl Acad Sci USA. 1968;59:94-101. CrossrefMedlineGoogle Scholar2. NIEDERMAN J, MCCOLLUM R, HENLE G, and HENLE W. Infectious mononucleosis: clinical manifestations in relation to EB virus antibodies. JAMA. 1968;203:205-9. CrossrefMedlineGoogle Scholar3. EVANS A, NIEDERMAN J, and MCCOLLUM R. Seroepidemiologic studies of infectious mononucleosis with EB virus. N Engl J Med. 1968;279:1121-7. CrossrefMedlineGoogle Scholar4. HAMPAR B, HSU K, MARTOS L, and WALKER J. 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NIEDERMAN, M.D.Affiliations: Yale University School of Medicine New Haven, Connecticut PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEpstein-Barr VirusChronic Fatigue Syndrome: A ConundrumEpstein-Barr VirusSyndrome infectieux inapparent à virus Epstein-Barr et sport de haut niveau. À propos de 15 observationsEpstein-Barr VirusOverview of immunopathology of chronic active herpesvirus infectionInfectious Mononucleosis: Recognition and Management in Athletes 1 January 1985Volume 102, Issue 1 Page: 119-121 Keywords B cells Blood Cell cultures Epstein-Barr virus Lymphocytes ePublished: 1 December 2008 Issue Published: 1 January 1985 PDF downloadLoading ...