The Carbohydrate Intolerance of Uremic Patients
Authors: FRED B. WESTERVELT
Journal: Annals of Internal Medicine (1962)

Article1 August 1962The Carbohydrate Intolerance of Uremic PatientsFRED B. WESTERVELT JR., M.D., GEORGE E. SCHREINER, M.D., F.A.C.P.FRED B. WESTERVELT JR., M.D.Search for more papers by this author, GEORGE E. SCHREINER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-57-2-266 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the past half century a substantial number of clinical investigators have observed hyperglycemia in patients with renal failure and azotemia (1-3).The present investigation of this biochemical aberration, termed "azotemic pseudodiabetes," was undertaken with 3 objectives:1. To reconfirm the existence of impaired glucose tolerance in azotemic subjects;2. To attempt to characterize the abnormality in a fashion which would be of clinical utility in differentiating true diabetes in an azotemic subject from azotemic pseudodiabetes; and3. To approach, if possible, a tenable biochemical explanation for its existence.CLINICAL MATERIALHospital staff and patients without metabolic disease served as...References1. MYERSBAILEY VCCV: The Lewis and Benedict method for the estimation of blood sugar, with some observations obtained in disease. J. Biol. Chem. 24: 147, 1916. CrossrefGoogle Scholar2. LINDERHILLERVAN SLYKE GCADD: Carbohydrate metabolism in nephritis. J. Clin. Invest. 1: 247, 1924. CrossrefGoogle Scholar3. PERKOFFTHOMASNEWTONSELLMANTYLER GTCCJDJCFH: Mechanism of impaired glucose tolerance in uremia and experimental hyperazotemia. Diabetes 7: 375, 1958. CrossrefMedlineGoogle Scholar4. PATTERSONLAZAROW JWH: Determination of glutathione by alloxan complexing. Meth. Biochem. Anal. 2: 256, 1955. Google Scholar5. 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COHENSPRITZRUBINSLUCKEY BDNALEH: Hyperguanidinemia and hypoglycemic unresponsiveness in renal disease. (Abstract) Ann. Intern. Med. 54: 1062, 1961. LinkGoogle Scholar32. BENESCHBENESCHROGERS RREWI: in Glutathione Symposium, Academic Press, Inc., New York, 1954, p. 31. CrossrefGoogle Scholar33. WILLIAMSHAYTJADEN RHJSMB: Degradation of insulin-I131 and glucagon-I131 and factors influencing it. Ann. N. Y. Acad. Sci. 74: (3), 513, 1959. CrossrefMedlineGoogle Scholar34. LAHMANNSCHLOSSMANN HHJ: The cation of cell-free muscle extract on insulin. J. Physiol. 95: 15P, 1939. Google Scholar35. NARAHARAWILLIAMS HTRH: Reduction of insulin by an extract of rat liver. Quoted in reference 33. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.From the Department of Medicine, Georgetown University School of Medicine, and the Renal and Electrolyte Division, Georgetown University Hospital, Washington, D. C.Dr. Westervelt is a research fellow in renal disease, supported in part by grant AT-446, National Institute of Arthritis and Metabolic Diseases.This work was facilitated by support of the John Hartford Foundation and Georgetown University Kidney Research Fund.Requests for reprints should be addressed to George E. Schreiner, M.D., Renal and Electrolyte Division, Georgetown University Hospital, 3800 Reservoir Road, N. W., Washington 7, D. C. 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ENGBRING, M.D.ROLE OF INSULIN IN GLUCOSE INTOLERANCE IN URÆMIAParenteral nutrition in renal failure.Diabetes and Renal DiseaseEtude de la glycor�gulation dans l'insuffisance r�nale chronique 1Abnormal carbohydrate metabolism in renal failureHazards and Complications of DialysisIsolation of N-methyl-2-pyridone-5-carboxamide from hemodialysis fluid obtained from uremic patientsElliptocytosis with Haemolytic AnaemiaInsulin inhibition and antagonismReports of SocietiesManagement of chronic renal failureConsiderations in the patient with diminished renal functionUntersuchungen zum Kohlenhydratstoffwechsel bei Niereninsuffizienz 1 August 1962Volume 57, Issue 2_Part_1Page: 266-276KeywordsGlucose intoleranceHospital medicineHyperglycemiaInsulinKidneysMetabolic disordersPatientsRenal diseasesRenal failureResearch funding Issue Published: 1 August 1962 PDF DownloadLoading ...