HEPATIC DAMAGE ASSOCIATED WITH SULFONAMIDE THERAPY IN INFANTS AND CHILDREN. II. CHANGES IN LIVER FUNCTION TEST DURING SULFONAMIDE THERAPY
Authors: Marie A. Andersch
Journal: Annals of Internal Medicine (1943)

Article1 October 1943HEPATIC DAMAGE ASSOCIATED WITH SULFONAMIDE THERAPY IN INFANTS AND CHILDREN. II. CHANGES IN LIVER FUNCTION TEST DURING SULFONAMIDE THERAPYMARIE A. ANDERSCH, PH.D.MARIE A. ANDERSCH, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-4-622 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSulfonamides have proved effective in the treatment of many infections, and in only a few instances have there been reports of clinical signs of liver dysfunction. This, however, may occasionally occur. The evidence offered in the previous paper of liver disease at times associated with sulfonamide therapy in children led to an investigation of the possibility of the early detection of hepatic damage during treatment. Liver function tests based on alteration of plasma globulin appear to be exceedingly sensitive, and with the use of one of these tests it has been possible to detect changes in liver which occurred during...Bibliography1. DEBONIS G: Toxicity of sulfanilamide for liver, Athena, 1940, ix, 225; Abstr. Jr. Am. Med. Assoc., 1940, cxv, 1928. Google Scholar2. WATSONSPINK CJWW: Effect of sulfanilamide and sulfapyridine on hemoglobin, Arch. Int. Med., 1940, lxv, 825-846. CrossrefGoogle Scholar3. COLEHARNED VVBK: The effects of a diet deficient in vitamin B on the toxicity of sulfapyridine, Federation Proc., 1942, i, 147. Google Scholar4. GRAY SJ: The colloidal gold reaction of blood serum in diseases of the liver, Arch. Int. Med., 1940, lxv, 524-544. CrossrefGoogle Scholar5. MATEERBALTZMARIONHOLLAND JGJJDFRA: A comparative evaluation of the newer liver function tests, Am. Jr. Digest. Dis., 1942, ix, 13-29. CrossrefGoogle Scholar6. BRATTENMARSHALL ACEK: A coupling component for sulfanilamide determination, Jr. Biol. Chem., 1939, cxxviii, 537-550. CrossrefGoogle Scholar7. STILES MH: Hypersensitivity to small doses of sulfathiazole, Jr. Pennsylvania Med. Assoc., 1941, xxxxiv, 823-824. Google Scholar8. RAVDIN IS: The protection of the liver from injury, Surg., 1940, viii, 204-211. Google Scholar9. MESSINGERHAWKINS WJWB: Arsphenamine liver injury modified by diet, Am. Jr. Med. Sci., 1940, cic, 216-225. CrossrefGoogle Scholar10. DAVISWHIPPLE NCGH: The influence of fasting and various diets on the liver injury effected by chloroform anesthesia, Arch. Int. Med, 1919, xxiii, 612-635. CrossrefGoogle Scholar11. MILLERWHIPPLE LLGH: Chloroform injury increases as protein stores decrease, Am. Jr. Med. Sci., 1940, cic, 204-216. CrossrefGoogle Scholar12. TALLERMANN KH: Ketosis accompanying infections in children, Am. Jr. Dis. Child., 1925, xxx, 476-482. Google Scholar13. KAPNICKLYONSSTEWART ICJD: Influence of diet on sulfanilamide toxicity, Jr. Pharmacol. and Exper. Therap., 1942, lxxiv, 284-289. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Pittsburgh, Pennsylvania*Received for publication June 29, 1942. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySTREPTOMYCIN AND PROMIZOLE IN MILIARY TUBERCULOSIS AND TUBERCULOUS MENINGITIS IN CHILDREN 1 October 1943Volume 19, Issue 4Page: 622-628KeywordsBlood plasmaChildrenGlobulinsInfantsLiverLiver diseasesLiver function testsSulfonamide ePublished: 1 December 2008 Issue Published: 1 October 1943 PDF downloadLoading ...