tbuckley/cabot-search huggingface dataset:
Abstract 16163: Foxc2 is Required for Neovascularization During Ischemic Tissue Repair After Myocardial Infarction
Authors: Hyun-Young Koo, Kyoo S Shim, Ting Liu, Sol Misener, Chistine Kamide, Meredith Millay, Douglas Losordo, Tsutomu Kume
Journal: Circulation (2011)

Rationale: The Foxc2 transcription factor has been implicated in vascular development. We have recently demonstrated that Foxc2 is an important regulator of tumor angiogenesis; however, the role of...
Abstract 16209: Performance of Multislice CT and Added Value of 18FDG-PET/ CT Image Fusion in Detecting Prosthetic Valve Dysfunction and Infection: Comparative Study With Echocardiography and Surgery
Authors: Gudrun Feuchtner, Silvana Muller, Fabian Plank, Thomas Schachner, Thomas Bartel, Christian Uprimny, Nikolaos Bonaros, Ricardo Cury, Guy Friedrich, Andre Plass
Journal: Circulation (2010)
High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial
Authors: Fin Stolze Larsen, Lars Ebbe Schmidt, Christine Bernsmeier, Allan Rasmussen, Helena Isoniemi, Vishal C. Patel, Evangelos Triantafyllou, William Bernal, Georg Auzinger, Debbie Shawcross, Martin Eefsen, Peter Nissen Bjerring, Jens Otto Clemmesen, Krister Hockerstedt, Hans-Jørgen Frederiksen, Bent Adel Hansen, Charalambos G. Antoniades, Julia Wendon
Journal: Journal of Hepatology (2015)
Neurotoxic effects of occupational exposure to organotins
Authors: W D Ross, E A Emmett, J Steiner, R Tureen
Journal: American Journal of Psychiatry (1981)

The authors gave 22 chemical workers neurological, psychiatric, and neuropsychological examinations and placed them in one of two groups according to their degree of exposure to trimethyltin chloride spillage during January 1978. Other chemicals to which they had been exposed were dimethyltin dichloride and methyl chloride. Specific and nonspecific symptoms of intoxication of the CNS showed a significantly greater frequency in the highly exposed group, including cycles of depression and destructive rage, each lasting a few hours. These observations should alert diagnosticians to this type of occupational exposure.
纳差-腰背痛-少尿
Authors: 叶秋月, 吴东, 郭毅, 杜薇, 周道斌
Journal: BMJ (2008)

患者男,61岁,入院前3个月无明显诱因出现纳差,无发热、恶心、呕吐、乏力,无腹痛、腹泻,无尿量减少、体重下降等.2个月前于外院查血ALT 18 U/L,尿素氮6.36 mmol/L,肌酐116μmol/L,血糖4.9 mmol/L.对症处理症状改善不明显。
Abstract 17712: Similar Survival but Higher Incidence of Hardware-Related Complications in Female Implantable Cardioverter Defibrillator Recipients
Authors: Gabor Z Duray, Joern Schmitt, Agnes Fink, Joachim R Ehrlich, Stefan H Hohnloser
Journal: Circulation (2010)

Methods: We analyzed all consecutive ICD recipients implanted at our institution between 1/2000 and 12/2006. The all cause mortality, the annual and cumulative incidence of Re-Sx for ICD system com...
The Intestinal Brush Border Membrane in Diabetes
Authors: Ward A. Olsen, Helen Korsmo
Journal: Journal of Clinical Investigation (1977)

Diabetes stimulates the functional activity of the intestinal brush border membrane with enhancement of both hydrolytic enzyme activity and membrane transport systems. To determine the mechanism of this effect, we studied the effects of streptozotocin diabetes on the metabolism of one membrane protein, sucrase-isomaltase, which increases its activity in diabetes. The protein was purified and an antiserum prepared. Sucrase-isomaltase from control and diabetic rats was immunologically identical as shown by Ouchterlony double-diffusion analysis of papain-solubilized mucosal proteins. The increase in sucrase enzyme activity in diabetic animals (31.0±1.4 U SEM 5 days after streptozotocin vs. 13.1±1.0 in controls) was the consequence of increased enzyme protein and not an alteration in catalytic efficiency as demonstrated by quantitative immunoprecipitin reactions.
Abstract A52: Myc is required for maintenance of KRasG12D-driven pancreatic cancer and its associated microenvironment
Authors: Nicole M. Sodir, Laura Soucek, Trevor D. Littlewood, Mark J. Arends, Gerard I. Evan
Journal: Cancer Research (2015)

Abstract The frequent occurrence of Myc deregulation in human cancers makes Myc an intriguing potential therapeutic target. This is supported by recent studies demonstrating that Myc inhibition (via expression of a dominant negative Myc mutant) triggers regression of SV40-driven pancreatic islet tumors and KRasG12D-driven lung tumors in mice. In the case of insulinoma, regression is presaged by collapse of the tumor microenvironment and involution of the tumor vasculature. One feature of human pancreatic ductal adenocarcinoma (PDAC) is its extensive stromal component (desmoplasia) that is thought to contribute to the resistance of PDAC to current therapies. We show that systemic Myc inhibition in the well-established KRasG12D-driven PDAC mouse model triggers regression of both tumor and its associated desmoplastic stroma, indicating that endogenous Myc function in the tumor cells is required for maintenance of the desmoplastic reaction. Consistent with this, ectopic expression of physiological levels of deregulated Myc enhances pancreatic tumor progression and drives stromal desmoplasia, and this reverses upon cessation of deregulated Myc. That systemic Myc inhibition causes regression of both tumor and its associated stroma, while ectopic activation of Myc in tumor cells drives both tumor progression and desmoplasia, confirm that Myc serves an essential and non-redundant role, coupling diverse intracellular oncogenic pathways to the tumor microenvironment, and underscoring its credentials as a pharmacological target in cancers driven by different oncogenes and arising in different tissues. Citation Format: Nicole M. Sodir, Laura Soucek, Trevor D. Littlewood, Mark J. Arends, Gerard I. Evan. Myc is required for maintenance of KRasG12D-driven pancreatic cancer and its associated microenvironment. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Innovations in Research and Treatment; May 18-21, 2014; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2015;75(13 Suppl):Abstract nr A52.
Significant increase of listeriosis in Germany - Epidemiological patterns 2001-2005
Authors: J Koch, K Stark
Journal: Eurosurveillance (2006)

Listeriosis has been a mandatorily notifiable disease in Germany since January 2001. Clinical cases with isolation of Listeria monocytogenes from sterile specimens or neonates are reported to the Robert Koch-Institut. Listeriosis incidence significantly increased from 0.26 per 100 000 inhabitants (217 cases) in 2001 to 0.62 per 100 000 (519 cases) in 2005.
Modified leukotomy in the treatment of intractable obessional neurosis
Authors: J Tippin, F A Henn
Journal: American Journal of Psychiatry (1982)

Modified leukotomies were performed on 5 patients with severe, incapacitating obsessional neurosis. Symptoms had been present for 6 or more years in all patients, and 3 had been ill for more than 20 years. All had received adequate trials of more conventional treatments before the leukotomy but had shown little response. At the time of follow-up, which range from as early as 1 year to as late as nearly 7 years after surgery, each patient's condition had improved. One was considered to be in "full remission," there were "much improved," and one was still symptomatic but "improved."
Abstract 3383: MicroRNA Let-7f Augments Angiogenic Properties of Endothelial Progenitor Cells through AMPK Activation and MnSOD Induction in Type 1 Diabetes
Authors: Xiao-Rong Wang, Yun Zhang, Alex F Chen
Journal: Circulation (2008)

Introduction: Endothelial progenitor cells (EPCs) play an essential role in angiogenesis, but are dysfunctional in diabetes featuring excessive oxidative stress. Activation of AMP-activated protein...
Diagnosis and management of chronic sinusitis
Authors: A. C Maclennan, G. W McGarry
Journal: BMJ (1995)

Dying for palliatve care General practitioners have a crucial role EDrTOR,-The anonymous diary of a surgeon's death arouses compassion but also suggests that the general practitioner, who has a crucial role in palliative care, played a small part.'The general practitioner made a referral to hospital in August 1993 but seems to have had no part in the first two admissions, the decision to go to South Africa, or the subsequent hospital based treatment in March 1994 after the diagnosis of leukaemia.Serious difficulties in communication and considerable distress are described, but all we are told is that, three days after discharge from hospital, on 12 July, "Our GP called: asked for the third time
Clinical and Translational Results of a Phase II, Randomized Trial of an Anti–IGF-1R (Cixutumumab) in Women with Breast Cancer That Progressed on Endocrine Therapy
Authors: William J. Gradishar, Denise A. Yardley, Rachel Layman, Joseph A. Sparano, Ellen Chuang, Donald W. Northfelt, Gary N. Schwartz, Hagop Youssoufian, Shande Tang, Ruslan Novosiadly, Amelie Forest, Tuan S. Nguyen, Jan Cosaert, Dmitri Grebennik, Paul Haluska
Journal: Clinical Cancer Research (2015)

Abstract Purpose: This phase II trial evaluated the efficacy and safety of cixutumumab, a human anti–insulin-like growth factor receptor 1 (IGF-1R) monoclonal IgG1 antibody, and explored potential biomarkers in postmenopausal women with hormone receptor–positive breast cancer. Experimental Design: Patients with hormone receptor–positive breast cancer that progressed on antiestrogen therapy received (2:1 randomization) cixutumumab 10 mg/kg and the same antiestrogen (arm A) or cixutumumab alone (arm B) every 2 weeks (q2w). Primary endpoint was progression-free survival (PFS); secondary endpoints included overall survival (OS) and safety. Correlative analyses of IGF-1R, total insulin receptor (IR), and IR isoforms A (IR-A) and B (IR-B) expression in tumor tissue were explored. Results: Ninety-three patients were randomized (arm A, n = 62; arm B, n = 31). Median PFS was 2.0 and 3.1 months for arm A and arm B, respectively. Secondary efficacy measures were similar between the arms. Overall, cixutumumab was well tolerated. IGF-1R expression was not associated with clinical outcomes. Regardless of the treatment, lower IR-A, IR-B, and total IR mRNA expression in tumor tissue was significantly associated with longer PFS [IR-A: HR, 2.62 (P = 0.0062); IR-B: HR, 2.21 (P = 0.0202); and total IR: HR, 2.18 (P = 0.0230)] and OS [IR-A: HR, 2.94 (P = 0.0156); IR-B: HR, 2.69 (P = 0.0245); and total IR: HR, 2.72 (P = 0.0231)]. Conclusions: Cixutumumab (10 mg/kg) with or without antiestrogen q2w had an acceptable safety profile, but no significant clinical efficacy. Patients with low total IR, IR-A, and IR-B mRNA expression levels had significantly longer PFS and OS, independent of the treatment. The prognostic or predictive value of IR as a biomarker for IGF-1R–targeted therapies requires further validation. Clin Cancer Res; 22(2); 301–9. ©2015 AACR.
Abstract 8171: Invasive Assessment of Atrioventricular Conduction Changes Following Transcatheter Aortic Valve Implantation with Self-expandable or Balloon-Expandable Prosthesis
Authors: Anne Rollin, Nicolas Dumonteil, Pierre Mondoly, Bertrand Marcheix, Alexandre Duparc, Nicolas Boudou, Thibault Lhermusier, Mathieu Gautier, D Tchétché, Marc Delay, Philippe Maury, Didier Carrié
Journal: Circulation (2011)

Background: Atrio-ventricular block (AVB) is one of the complications after transcatheter aortic valve implantation (TAVI), and is more frequent after implantation of a Medtronic CoreValve (MCV) than after implantation of an Edwards Sapien prosthesis (ES). The aim of this prospective study was to quantify and compare by invasive measurement the exact influence of TAVI with MCV or ES valve on atrioventricular conduction. Methods: between February 2010 and March 2011, consecutive patients who underwent TAVI with a MCV or an ES valve were included in this prospective, single center study. The His-Ventricle (HV) interval was measured during an electrophysiology study (EPS) before and at least 4 days after the procedure. Patients with pre-existent permanent PM implanted for AVB were excluded Results: 60 patients were included. 25 (42%) were treated with a MCV, and 35 (58%) with an ES valve. Mean age was 83±6 years, 62% men with no significant difference of baseline clinical, ECG, echocardiographic data, Logistic EuroScore and STS Score between MCV and ES groups. There was no peri-procedural death. HV interval measurement was feasible in all patients. 19 patients (32%) needed implantation of a permanent PM. Indication was persistent complete AVB in 12 patients (20%) and transient high grade AVB in 4 patients (7%). PM implantation was required in 6 patients (17%) with ES valve and 13 patients (52%) with MCV (Odds Ratio: 6.8, [95% CI 1.9-24.8] p&lt;0.01). HV interval remained stable (increased duration ≤5ms) in 10 patients (30%) with ES valve and in 5 patients (20%) with MCV (p: 0. 15). HV interval was prolonged by 10ms or more after procedure in 12 patients (35%) with ES valve and in 17 patients (68%) with MCV (Odds Ratio: 5. [95% CI 1. 5-16.9] p&lt;0.01). Conclusion: This study supports the fact that atrioventricular and particularly infrahisian conductive tissue is frequently impaired after TAVI. This damage is more frequent and more severe with MCV compared with ES valve.
Abstract 5326: S100A1 Prevents Arrhythmogenic Diastolic Sarcoplasmic Reticulum Calcium Leak In Ventricular Cardiomyocytes
Authors: Mirko Voelkers, Christian Weidenhammer, Nicole Herzog, Oliver Friedrich, Rainer H Fink, Walter J Koch, Hugo A Katus, Steven S Soltys, Joseph Rabinowitz, Patrick Most
Journal: Circulation (2008)

Background: S100A1 is an inotropic calcium (Ca) sensor protein in cardiomyocytes interacting with the cardiac ryanodine receptor (RyR2). Previous studies of our group have shown that S100A1 protein can decrease Ca spark frequency in permeabilized ventricular cardiomyocytes (CMs). We therefore hypothesized that S100A1 might prevent arrhythmogenic sarcoplasmic reticulum (SR) Ca leak in CMs. Methods and Results: Ventricular rat cardiomyocytes were enzymatically isolated and transfected either with 10 MOI of a CMV-GFP control or CMV-S100A1/CMV-GFP adenovirus resulting in GFP fluorescence in &gt;99% of cultured GFP-CMs and S100A1-CMs as assessed by epifluorescent microscopy after 24-hours. Expression analysis revealed a 3-fold increase in S100A1 protein in S100A1-CM levels compared to GFP-CM. Confocal line-scan microscopy yielded a 50% reduction in Ca spark frequency in rhodamin2-AM loaded quiescent S100A1-CMs and epifluorescent imaging showed a 20% and 50% increase in the SR Ca content and systolic Ca transient amplitude, respectively, in FURA2-AM loaded 2Hz-stimulated S100A1-CM (37°C, 1.8 mM Ca) compared with GFP-CMs. Pathophysiological diastolic SR Ca leak was induced subjecting 2Hz-stimulated FURA2-AM loaded CMs to 0.5 mM caffeine and 10–7 M isoproterenol (caff/iso) as previously published by Isner and co-workers. As expected, this protocol resulted in permanent diastolic Ca waves in 100% (n=60/60) of 2Hz-stimulated iso/caff-treated GFP-CMs and was accompanied by significantly increased diastolic Ca levels and reduced systolic Ca transient amplitudes compared with iso-treated GFP-CMs. However, S100A1 efficiently protected more than 80% of iso/caff treated S100A1-CMs (n=49/60 cells, P&lt;0.05 vs. iso/caff GFP-CMs) from diastolic Ca waves and further alterations of CM Ca handling. Importantly, similar results were obtained in caff/iso-treated failing rat GFP- and S100A1-CMs (data not shown). Conclusions: Here we show for the first time that S100A1 can both diminish the physiological SR Ca leak and protect from arrhythmogenic Ca waves in CMs. Given its beneficial effects in the context of experimental HF animal models, S100A1 therapeutic inotropic actions might be complemented by an antiarrhythmic effect targeting dysfunctional RyR2.
Abstract P043: Does The Severity of Coronary Artery Disease Explain The Increased Risk of Death and Myocardial Infarction From Ambient Air Pollution Exposure?
Authors: Somjot S Brar, Denise Le, Sumit Khandhar, Dong Chang, Lindsay Short, Albert Shen, Prakash Mansukhani, Vicken Aharonian, Naing Moore, Steven Khan, Michael B Jorgensen
Journal: Circulation (2012)

BACKGROUND: Ambient air pollution from traffic increases cardiovascular morbidity and mortality and is associated with coronary artery calcification. Whether this increased risk is mediated by severity of coronary artery disease (CAD) remains unknown. METHODS: In this pilot study, the relationship between living near a major roadway and multivessel CAD confirmed by invasive coronary angiographic was explored. Subjects undergoing coronary angiography in the Los Angeles metropolitan area in 2009-10 were randomly selected. Investigators blinded to the exposure status reviewed coronary angiograms. Subjects were categorized as having: absence of or non-obstructive CAD, 1-vessel, 2-vessel, or 3-vessel CAD based upon the number of major epicardial vessels with &gt; 70% stenoses. The distance from each subject's residence to the nearest major road was calculated in meters. Multivariate logistic regression was used to explore the relationship between severity of CAD and distance to major roadway. RESULTS: There were 642 subjects undergoing coronary angiography. The mean age (SD) was 64 years (12) and 36% were female. In multivariate analysis log-road distance was a predictor of multivessel CAD, odds ratio (OR) = 0.85 (95%CI, 0.75-0.98; p=0. 02) after adjusting for age, gender, hypertension, and diabetes, and smoking status. Other predictors of multivessel CAD included from the multivariate logist model were: male gender (OR, 3.00, 95% CI, 2.06-4.39; p&lt;0.001), diabetes (OR, 2.49; 95% CI, 1.75-3.54; p&lt;0.001), and hypertension 2.58; 95%CI, 1.28-5.21; p=0.008). The most severe form of CAD, &gt;50% stenosis of the left main artery, was observed in 6.6% of the cohort. In a multivariate model, age (P = 0.002) and diabetes (P = 0.002) were significant predictors of severe left main disease; there was a trend for log-road distance (OR, 0.83; 95% CI, 0.67-1.02; P = 0.079) with left main disease. CONCLUSIONS: Multivessel CAD was strongly associated with traditional risk factors. After adjusting for these factors, living near a major roadway was also a predictor. This study demonstrates the feasibility of exploring the association between angiographic CAD and traffic pollution. Additional studies are needed to better understand the mechanisms underlying the increase in adverse cardiovascular events from air pollution.
New beginning for care for elderly people?
Authors: I. Philp, S. Ebrahim, P. Connelly, D. Jenkinson, G. Ford, R. J McManus, L. Lumley, M. Gough, L. Jhass, K. Deacon, R. C Tallis, J G. Evans
Journal: BMJ (2001)

New beginning for care for elderly people? National framework could transform care for older people in EnglandEditor-Grimley Evans and Tallis criticise the national service framework for older people. 1 I agree with them that the policy to reduce emergency admissions
Screening for Coronary Heart Disease: Recommendation Statement
Journal: Annals of Internal Medicine (2004)

This statement summarizes the current U.S. Preventive Services Task Force (USPSTF) recommendations on screening for coronary heart disease and the supporting scientific evidence and updates the 1996 recommendations on this topic. The complete information on which this statement is based, including evidence tables and references, is available in the background article and the systematic evidence review, available through the USPSTF Web site (www.preventiveservices.ahrq.gov) and through the National Guideline Clearinghouse (www.guideline.gov). The article and the recommendation statement are also available in print through the Agency for Healthcare Research and Quality Publications Clearinghouse (telephone, 800-358-9295; e-mail, ahrqpubs@ahrq.gov). *For a list of the members of the U.S. Preventive Services Task Force, see the Appendix.
Abstract 17622: Combination of Early Brain Natriuretic Peptide/Creatine Kinase-MB Ratio and QTc Prolongation Significantly Improves Differentiation of Takotsubo Cardiomyopathy from Acute Myocardial Infarction
Authors: Mandeep S Randhawa, Ashwat Dhillon, Milind Y Desai
Journal: Circulation (2012)

Background: Takotsubo Cardiomyopathy (TC) is a transient myocardial dysfunction that mimics acute myocardial infarction (AMI). Currently, these are differentiated by ruling out obstructive coronary...
Abstract 1828: Dyxin/Lmcd1 Mediates Cardiac Hypertrophy Both <i>In Vitro</i> And <i>In Vivo</i>
Authors: Derk Frank, Robert Frauen, Christiane Hanselmann, Christian Kuhn, Rainer Will, Hugo A Katus, Norbert Frey
Journal: Circulation (2008)

In order to identify new molecular mediators of cardiomyocyte hypertrophy, we performed a genome wide mRNA microarray screen of biomechanically stretched neonatal rat cardiomyocytes (NRCM). We found the novel sarcomeric LIM protein Dyxin/Lmcd1 being significantly upregulated (5.6x, p&lt;0.001). Moreover, Dyxin was also significantly induced in several mouse models of myocardial hypertrophy including aortic banding, calcineurin overexpression and angiotensin stimulation, suggesting a potential role as a mediator of cardiac hypertrophy. To further test this hypothesis, we adenovirally overexpressed Dyxin in NRCM which potently induced cellular hypertrophy (150%, p&lt;0.001) and the hypertrophic gene program (ANF, BNP). Consistent with an induction of calcineurin signalling, the calcineurin-responsive gene Rcan1– 4 (MCIP1.4) was found significantly upregulated (3.2x, p&lt;0.001). Conversely, knockdown of Dyxin (−75% on protein level) via miRNA completely blunted the hypertrophic response to hypertrophic stimuli, including stretch and PE (both p&lt;0.001). Furthermore, PE-mediated activation of calcineurin signaling (Upregulation of Rcan1– 4 by 7.3x, p&lt;0.001) was completely blocked by knockdown of Dyxin. To confirm these results in vivo, we next generated transgenic mice with cardiac-restricted overexpression of Dyxin using the α -MHC promoter. Despite normal cardiac function as assessed by echocardiography, adult transgenic mice displayed significant cardiac hypertrophy in morphometrical analyses (3.9 vs. 3.5 mg/g LV/heart weight, n=8–11, p&lt;0.05). This finding was supplemented by a robust induction of the hypertrophic gene program including ANF (3.7-fold, n=6, p=0.01) and α -skeletal actin (2.8-fold, n=6, p&lt;0.05). Likewise, Rcan1– 4 was found upregulated (+112%, n=5, p&lt;0.05), Taken together, we show that the novel sarcomeric z-disc protein Dyxin/Lmcd1 is significantly upregulated in several models of cardiac hypertrophy and potently induces cardiomyocyte hypertrophy both in vitro and in vivo. Mechanistically, Lmcd1/Dyxin appears to signal through the calcineurin pathway.