tbuckley/cabot-search huggingface dataset:
Abstract 7: Assessment of FSH receptor expression in the major molecular subtypes of breast cancer
Authors: François Planeix, Mohammad-Ahsan Siraj, François-Clément Bidard, Jean-Yves Pierga, Xavier Sastre, Martine Antoine, Nicolae Ghinea
Journal: Cancer Research (2014)

Abstract Recent data from our laboratory show that the follicle-stimulating hormone receptor (FSHR) is expressed on the endothelial surface of tumor peripheral blood vessels in different types of tumors including breast cancer. The main goal of the present study was to determine differences in the endothelial FSHR expression level among the breast cancer types, and within the same tumor type, among tumor stages. We have also compared the FSHR expression with the receptor status of three most important markers for breast cancer diagnosis and therapy (estrogen receptor, progesterone receptor, and HER-2/neu). By using a highly specific monoclonal antibody raised against the human FSHR, we determined the density of FSHR-positive vessels in a band with a width of 10 mm (centered on the demarcation line between the tumor and the normal breast tissue) on the tissue sections by standard peroxidase-immunohistochemistry and immunofluorescent confocal microscopy. We examined 35 patients of Luminal A, 13 patients of Luminal B, 19 patients of HER-2 positive, and 16 patients of Triple negative/basal breast cancer. All four groups expressed almost similar densities of FSHR stained blood vessels with 36.7 ± 4.0/mm2 in Luminal A, 31.4 ± 5.2/mm2 in Luminal B, 39.6 ± 6.0/mm2 in HER-2 positive tumors, and 38.4 ± 8.0/mm2 in triple negative/basal group. A positive correlation has been observed between the percentage of FSHR-positive vessels and total blood vessels in the tumor periphery (r = 0.551; p = 7e-08). We have also noticed a tendency (not reaching statistical significance) towards an overall decrease in the extent of the vascular bed in elder patients as compared to younger patients. No correlation was found between the percentage of FSHR-positive vessels and the expression of receptors for estrogen, progesterone, and HER-2/neu. In conclusion, our data show that: (i) FSHR is robustly expressed in breast cancer, and (ii) the main types of breast cancers and stages do not differ significantly in terms of vascular FSHR expression. These facts strongly increase FSHR potential relevance as a clinical target for breast cancer imaging and for therapy, especially for triple negative/basal breast cancers, a group with only chemotherapy options. Citation Format: François Planeix, Mohammad-Ahsan Siraj, François-Clément Bidard, Jean-Yves Pierga, Xavier Sastre, Martine Antoine, Nicolae Ghinea. Assessment of FSH receptor expression in the major molecular subtypes of breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 7. doi:10.1158/1538-7445.AM2014-7
MRSA in the ICU
Authors: Bridget M. Kuehn
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 18412: Long Non-coding RNA Meg3 Regulates Senescence-associated Genes and Controls Endothelial Cell Function
Authors: Reinier Boon, Patrick Hofmann, Katharina Michalik, Andrea Knau, Yuliya Ponomareva, Andreas Zeiher, Shizuka Uchida, Stefanie Dimmeler
Journal: Circulation (2014)

The majority of transcribed RNAs does not encode proteins, but function as regulatory RNAs. Non-protein-coding RNA are classified in short (&lt;200 nt) and long (&gt;200 nt) non-coding RNAs (lncRNAs). lncRNAs have been described to play an important role in many biological processes, including epigenetic regulation of gene expression. To determine the expression and functional role of lncRNAs in endothelial cells, we performed RNA deep sequencing of human umbilical venous endothelial cells (ECs). Among the highest expressed lncRNAs, we identified Maternally Expressed 3 (Meg3, 35.3±0.6 RPKM), which has been correlated to VEGF expression. In HUVECs, Meg3 localizes to the nucleus and is induced by hypoxia (4.08±0.78-fold, p&lt;0.05). Interestingly, Meg3 was also found to be induced in the intima of aged mice and correlates with age in human hearts (p=0.016). Meg3 levels are also induced in replicative senescent HUVECs in vitro (passage 16/17 vs 2/3, 2.9±0.99-fold).Conversely, silencing of Meg3 using LNA-GapmeRs induced angiogenic sprouting of endothelial cells in vitro (1.4±0.14-fold, P&lt;0.05) but did not affect caspase-3 activation. Mechanistically, RNA immunoprecipations showed that Meg3 associates specifically to H3K27me3, a silencing chromatin mark. Silencing of Meg3 in HUVECs induces a robust repression of global gene expression, as measured by exon array analysis, with a highly significant repression of the anti-senescent HMGA2. In summary these results demonstrate, that the lncRNA Meg3 is highly expressed in endothelial cells and is up-regulated by hypoxia and aging. Functionally, Meg3 inhibits sprouting angiogenesis in vitro. Meg3 depletion leads to a general repression of gene expression and the senescence marker HMGA2 likely by inducing the recruitment of silencing H3K27me3 marks to the promoters Therefore, modulating Meg3 may be a potential strategy to reduce endothelial senescence or increase regenerative angiogenesis.
Radiodontia (Dental Radiography and Diagnosis). Questions and Answers.
Authors: Howard Riley Raper
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 18960: Anti-PCSK9 VLP Immunization Reduces Cholesterol Levels in Mice and Non-human Primates
Authors: Marcelo Amar, Erin Crossey, John T Schiller, Bryce Chackerian, Alan T Remaley
Journal: Circulation (2014)

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory protease involved in cholesterol homeostasis by enhancing endosomal and lysosomal degradation of cell surface low-density lipoprotein receptors (LDL-R). While increased activity of PCSK9 has been associated with hypercholesterolemia and atherosclerosis, several healthy patients have also been identified with loss-of-function PCSK9 mutations and exhibit a hypocholesterolemia phenotype (and an extremely low incidence of coronary artery disease - CAD). These observations indicate that PCSK9 is an attractive target for the purpose of lowering circulating LDL-cholesterol, and therefore decreasing the potential for CAD and atherosclerosis. To date, several different strategies are being attempted to target and reduce plasma levels of PCSK9 but they are based on expensive therapies that may be utilized only by a limited number of patients. Phase 2 clinical studies utilizing monoclonal antibodies targeting PCSK9 demonstrated a reduction in LDL-c up to 70%. To reach a much broader population and design a low cost, long-term treatment, we developed a Virus-like Particle (VLP) based vaccine that targets the LDLR binding domain of PCSK9.

Immunized mice (n=20) developed high-titer anti-peptide IgG responses that cross-reacted with PCSK9. Total cholesterol, free cholesterol, phospholipid and triglyceride levels were measured after the final boost. Vaccination with PCSK9-VLPs significantly reduced all four of these measures, with total cholesterol decreasing by over 30% (relative to pre-vaccination levels). We also immunized small groups (n=3) of rhesus macaques. Vaccination resulted in changes in lipoprotein profile at week 2, and decreases in TC (14.2%), ApoB (13.4%) and LDL-p (28.4%) at week 6 were observed. The PCSK9-VLP vaccine was well tolerated with no signs of overt toxicity in both species. In conclusion, these findings suggest that VLP-PCSK9 immunization may be an accessible, low cost, and effective new therapy for hypercholesterolemia and CAD.
Abstract 5747: Outcomes of Individuals with Discordance Between the Framingham Risk Score and the Coronary Artery Calcification Score
Authors: Naser Ahmadi, David Choe, Sumit Khandhar, Gary P Foster
Journal: Circulation (2008)

Background: Traditional tools used to assign risk of future cardiovascular events, at times fail to accurately identify individuals with severe coronary artery disease. Outcomes of individuals with...
The Psychology of Responsibility
Authors: Johanna Shapiro, Deane H. Shapiro
Journal: New England Journal of Medicine (1979)

Humanism and holism have hit the medical profession with the searing force of righteous anger, and the health-care system will never be the same. As a powerful counterforce to the increasing technology and dehumanization of post-Flexnerian medicine,1 , 2 which posits an omnipotent technician-physician and a passive, helpless patient, humanism and holism emphasize consideration of the person rather than the disease,3 the interpersonal relations between physician and patient4 and the individual patient's responsibility as an initiating participant in his or her own health care.5 Responsibility is a key word in the humanistic rhetoric. People are encouraged to take responsibility for maintenance of . . .
Familial Susceptibility to Cancer
Authors: David E. Anderson
Journal: CA A Cancer Journal for Clinicians (1976)

1)oes a fain i/v Ii islorv of (/(â€˜I'('lO/)iil,t,' tiUlt (a1l('('i! of call('er i/ic rease an inthti(/ual â€˜¿ .sriskA number of retrospective studies conducted primarily during the first half of the century provided evidence indicating that a family history of a certain neoplasm could increase the risk for this cancer in first-degree relatives. Dr. Anderson
Suddenly, 64 Stem Cell Lines
Authors: B Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for Alcohol Problems
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Polarization of alveolar macrophages is regulated by the immunoproteasome
Authors: Shanze Chen, Ilona Keller, Oliver Vosyka, Anke-Gabriele Lenz, Oliver Eickelberg, Silke Meiners, Tobias Stoeger
Journal: European Respiratory Journal (2014)

Rationale: Alveolar macrophages (AMs) play an important role during inflammatory lung diseases. AM plasticity, a major requirement to adapt to the respective environment is i.a. archived by their polarization towards classically activated M1 or alternatively activated M2 phenotypes. The immunoproteasome (IP) is the specialized proteasome assemble that is particularly relevant in shaping immune responses. We therefore hypothesized that the IP contributes to M1/M2 polarization of alveolar macrophages.    Methods:   A murine AM cell line (MHS) and primary AMs purified from WT, or IP subunit LMP2-/- and LMP-/- mice, were stimulated with LPS (1μg/ml) and IFN-γ (20ng/ml) or IL-4 (20ng/ml) for 24h to induce M1 or M2 macrophage polarization, respectively. Expression of M1 and M2 marker genes was analyzed by q-PCR. Expression and IP activity was determined by western blot and the use of activity-based probes.    Results:   AMs could be polarized into M1 or M2 phenotypes confirmed by marker gene expression. Both at RNA and protein levels, M1 macrophages exhibited increased expression and activity of LMP2 and LMP7. Upon M2 polarization however, LMP2 and LMP7 mRNA levels revealed unchanged but protein levels were significantly induced. Further, M1 polarization was independent of LMP2/7 expression, but M2 polarization was clearly enhanced in LMP7 -/- , and diminished in LMP2 -/-  cells.    Conclusion:   Our study demonstrates that LMP7 activity enhances M2 polarization, while LMP2 ablation counteracts M2 polarization of AMs. For M1 polarization however LMP2 and LMP7 IP subunits are dispensable. These results might present a new avenue to modulate innate immunity in the lungs by inhibition of individual IP subunits.
Consultants reprimanded over false allegations
Authors: Clare Dyer
Journal: BMJ (2001)

Two consultant dermatologists were found guilty last week by the General Medical Council of serious professional misconduct for passing on false allegations that a member of an appointments committee might be biased.

Jeffrey Cream, a consultant at the Chelsea and Westminster, Charing Cross, and West Middlesex Hospitals and Pauline Dowd, a consultant at University College London Hospitals, were reprimanded by the GMC's professional conduct committee.

Dr Cream had had reservations about a proposed new consultant dermatologist post at …
Abstract P217: Coagulation Factor IX Levels and Risk of Stroke and Coronary Heart Disease: The REasons for Geographic And Racial Differences in Stroke Study (REGARDS)
Authors: Nels C Olson, Mary Cushman, Suzanne Judd, Brett Kissela, Monika M Safford, Frits R Rosendaal, George Howard, Neil A Zakai
Journal: Circulation (2014)

Introduction: The role of coagulation in coronary heart disease (CHD) and stroke remains controversial. We examined the association of levels of coagulation factor IX (FIX) with incident CHD and ischemic stroke in REGARDS. Methods: REGARDS recruited 30,239 participants in their homes across the contiguous U.S. between 2003-07; by design 41% were black, 55% female, and 56% lived in the southeast. Levels of FIX were measured in participants with incident CHD (n=654), incident stroke (n=646), and in a cohort random sample (n=1,104). Cox models were used to calculate the hazard ratio (HR) per standard deviation (SD) higher FIX level for incident CHD and stroke adjusting for traditional cardiovascular disease (CVD) risk factors, and testing a race by FIX interaction term. Participants with hemorrhagic stroke were excluded from the stroke analyses (n=73). Results: Levels of FIX were higher with increasing age, black race, female gender, diabetes, hypertension, dyslipidemia, and among those living in the southeastern U.S. (all p&lt;0.0001). As shown in the table, FIX levels (per 1 SD higher) were associated with CHD, but not stroke, after adjustment for CVD risk factors. When stratified by race, the association with CHD was stronger in blacks than whites (p-interaction = 0.08) with no association for stroke in either blacks or whites (p-interaction 0.71). Analyses of FIX by quintiles did not alter the results. Discussion: Levels of coagulation factor IX were significantly associated with incident CHD, but not stroke in blacks but not whites, after adjustment for CVD risk factors. These data suggest that higher levels of FIX are a risk factor for CHD in blacks but not whites, and may indicate different roles for hemostasis in vascular disease risk by race and by vascular disease type.
Transfusion of erythrocyte concentrates produces a variable increment on cerebral oxygenation in patients with severe traumatic brain injury
Authors: Santiago Ramón Leal-Noval, María Dolores Rincón-Ferrari, Ana Marin-Niebla, Aurelio Cayuela, Victoria Arellano-Orden, Antonio Marín-Caballos, Rosario Amaya-Villar, Carmen Ferrándiz-Millón, Francisco Murillo-Cabeza
Journal: Intensive Care Medicine (2006)
DIAGNOSIS AND TREATMENT OF CERTAIN TYPES OF CHRONIC DIARRHEA
Authors: Philip W. Brown
Journal: Annals of Internal Medicine (1934)

Article1 July 1934DIAGNOSIS AND TREATMENT OF CERTAIN TYPES OF CHRONIC DIARRHEAPHILIP W. BROWN, M.D., F.A.C.P.PHILIP W. BROWN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-1-93 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn fully two-thirds of the cases of chronic diarrhea encountered at The Mayo Clinic there are no definite findings to explain the trouble. These patients usually have drifted from one place to another, have followed dietary fads, and have had the colon flushed. They constitute a puzzling group for both diagnosis and treatment.There is a so-called harmless type of diarrhea which does not impair the patient's health; this may be present for years and the weight may be normal or even above normal; anemia is not present, and other laboratory studies give negative results. This type may be thought...Bibliography1. DORSTMORRIS SERS: Bacterial hypersensitivity of intestinal tract, Am. Jr. Med. Sci., 1930, clxxx, 650-656. CrossrefGoogle Scholar2. ROWE AH: Food allergy; its manifestations, diagnosis and treatment, Jr. Am. Med. Assoc., 1928, xci, 1623-1631. CrossrefGoogle Scholar3. VAUGHAN WT: Food allergens; trial diets in elimination of allergenic foods, Jr. Immunol., 1931, xx, 313-332. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Read before the American College of Physicians, Chicago, Illinois, April 17, 1934.From the Division of Medicine, The Mayo Clinic, Rochester, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1934Volume 8, Issue 1Page: 93-99KeywordsAnemiaChronic diarrheaColonDiarrheaResearch laboratories ePublished: 1 December 2008 Issue Published: 1 July 1934 PDF downloadLoading ...
Abstract 4070: Increased CRP and Long Term Risk for Cardiovascular Events in Middle Age Men and Women
Authors: Peter W Wilson, Ralph B D'Agostino, Lisa Sullivan, Christopher J O'Donnell
Journal: Circulation (2006)

The roles of high sensitivity C-reactive protein (CRP) and homocysteine (Hcys) levels on long-term risk for coronary heart disease (CHD) and other cardiovascular disease outcomes (CVD) were assesse...
Epidermolysis bullosa hereditaria letalis.
Authors: LAWRENCE SCHACHNER, GERALD S. LAZARUS, HERBERT DEMBITZER
Journal: British Journal of Dermatology (1977)

A patient with epidermolysis bullosa hereditaria letalis had the characteristic electron microscopic lesions not only in the skin, but also in the gastro‐intestinal, genito‐urinary and respiratory tracts. Administration of dexamethasone to this patient resulted in a significant decrease in the blistering. Although the patient died, long term survival in this disease is not rare. We report that staining tissue specimens from patients with epidermolysis bullosa with fluorescein‐labelled bullous pemphigoid antibody is a reliable method for differentiating between junctional and dystrophic disease.