tbuckley/cabot-search huggingface dataset:
German experts cause controversy after calling for atomoxetine to be withdrawn
Authors: N. Stafford
Journal: BMJ (2008)

The German subsidiary of Eli Lilly has strongly defended the firm’s drug atomoxetine, which is used to treat children with attention-deficit/hyperactivity disorder, after experts were quoted on a German television news report as urging the drug’s withdrawal from the market

The German controversy comes shortly after Lilly changed the drug’s warning label in Europe to conform to the label already used in the United States. A spokesperson for the United Kingdom’s Medicines and Healthcare Products Regulatory Agency told the BMJ that changes to the UK label “include the addition of information regarding the risk of onset or exacerbation of serious psychiatric disorders including psychotic reactions, hallucinations, mania, and agitation.”

The change is not the first major European-wide regulatory action taken on atomoxetine, which has been marketed by Lilly under the brand name Strattera in the US since 2002 and the UK since 2004, the agency spokesperson …
Randomized, double-blind comparison of 1 mg/L versus 5 mg/L methoxsalen bath-PUVA therapy for chronic plaque-type psoriasis
Authors: Rujirat Vongthongsri, Reinhard Konschitzky, Arno Seeber, Christina Treitl, Herbert Hönigsmann, Adrian Tanew
Journal: Journal of the American Academy of Dermatology (2006)
Single photon emission computed tomography with thallium-201 during adenosine-induced coronary hyperemia: Correlation with coronary arteriography, exercise thallium imaging and two-dimensional echocardiography
Authors: Thach Nguyen, Jaekyeong Heo, J.David Ogilby, Abdulmassih S. Iskandrian
Journal: Journal of the American College of Cardiology (1990)
The Management of Patients with Colorectal Adenomas
Authors: R. Lambert, L. H. Sobin, J. D. Waye, G. A. Stalder
Journal: CA A Cancer Journal for Clinicians (1984)

The management of a patient with a colorectal adenoma aims at removal of adenomas that are missed initially or develop subsequently. Classification of adenomas permits the separation of patients into those at minimal and high risk of developing recurrent or new adenomas. Follow-up schedules for these two groups are based on currently available clinical and pathologic data.
Sexual Dimorphism in the Electrocardiographic Dynamics of Human Ventricular Repolarization
Authors: Michael H. Lehmann, Hua Yang
Journal: Circulation (2001)

Background —Previous characterizations of sex differences in ST-T waveform voltages have largely focused on amplitudes at selected time points during repolarization, subject to potential distortions from variations in heart rate (HR) or reliance on a JT-normalized time scale. Methods and Results —Using digitized 12-lead ECGs from 553 normal adults (426 males) with HRs confined to 60±1, 70±1, or 80±1 bpm, we derived X, Y, and Z lead voltages and then generated, for each HR category by sex, summary (population mean) resultant spatial vector amplitudes (ST-T XYZ ) and instantaneous slopes (dV/dt XYZ ) at successive 4-ms intervals following the J point. Within each HR category, there was an early intersex divergence of ST-T XYZ trajectories (95% CIs nonoverlapping), with men exhibiting 2- to 3-fold greater dV/dt XYZ values during the ST segment and achieving greater maximum T XYZ and dV/dt XYZ values than women; descending T XYZ limbs were relatively more concordant between sexes but still steeper in men. The early sex differences in repolarization dynamics persisted in multiple regression analyses that took into account age and a morphometric index of left ventricular mass. In men, absolute values of extrema of T XYZ and dV/dt XYZ varied inversely with HR. Conclusions —At physiological resting HRs, the spatial ST-T vector voltage time trajectory is steeper in men than in women, beginning virtually from the J point. In addition to its mechanistic implications, the demonstration of marked sensitivity of ST-T XYZ and especially dV/dt XYZ to sex raises the possibility that these time-based, ECG-derived parameters might be informative in pathophysiological studies of ventricular repolarization.
John Bryan McFarland
Authors: J. Temple
Journal: BMJ (2014)

John Bryan McFarland, a well known and much respected Liverpool surgeon, has died aged 83 in Majorca, where he retired some 22 years ago. He went to school at Trearddur House, in Anglesey, and then Shrewsbury. Like his father Bryan, a professor of orthopaedics in Liverpool, he spent his professional life working as a surgeon in the city of his birth. He had two younger brothers, one of whom died tragically early and this left deep scar on John throughout his life.

After preregistration appointments in Liverpool and Edinburgh, he did his national service in the Royal Army Medical Corps, serving principally in Kenya at the time of the “troubles,” where, perhaps interestingly, he worked mainly as an anaesthetist.

After his early training as a surgeon in Liverpool, he then spent some time as a research fellow in America, this endeavour culminating in the award of an …
Use of Thoracic-Duct Cannulation in the Diagnosis of Tuberculous Enteritis
Authors: Marlys Hearst Witte, Lawrence Horowitz, Allan E. Dumont
Journal: New England Journal of Medicine (1963)

IN the absence of active pulmonary tuberculosis the diagnosis of tuberculous enteritis is usually definitively established only after exploratory laparotomy. This report concerns a patient with tuberculous enteritis in whom the clinical diagnosis was confirmed by isolation of tubercle bacilli from thoracic-duct lymph.Case ReportB.S., a 26-year-old Negro, was admitted to Bellevue Hospital on June 27, 1962, because of postprandial bloating and epigastric and mid-abdominal soreness of 5 months' duration. These symptoms were initially accompanied by 4 or 5 nonfloating, watery stools each day and moderate tenesmus. Without treatment the abdominal pain subsided, and the diarrhea disappeared. Three months . . .
Instruments for Fen Cho Fu Hospital.
Authors: Mary A. Atwood
Journal: JAMA (1898)

Sioux City, Iowa, Sept. 19, 1898. <h3>To the Editor:</h3> —Thanks are due to theJournalas well as Dr. Webster of Chicago and Dr. Green of Dubuque, Iowa, for so soon as their gift of surgical instruments arrives at Fen Cho Fu Hospital, Dr. Atwood will no longer have to amputate limbs with a saw made of a piece of band iron. The appeal through theJournaland the response by the doctors sends the instruments. Very respectfully,
Government rejects independent verification of all death certificates
Authors: Michael Day
Journal: BMJ (2006)

Plans for a radical overhaul of the system of coroner's courts in England and Wales have been announced by the government.Harriet Harman, minister for constitutional affairs, said the Coroner Reform Bill would do away with the "postcode lottery" of the current system, in which many bereaved people were left feeling "like spectators."Campaigners and doctors' leaders welcomed the draft bill's commitment to national standards, greater court powers, and dedicated medical advice for coroners.They warned, however, that the plans might not be enough to protect the public from a repeat of cases such as the Harold Shipman killings.The draft bill rejects some recommendations from Janet Smith's official inquiry into the Shipman killings, including her call for all death certificates to be independently verified.As a
Hammering psychiatric practice: ECT gets a bad press
Authors: B. Pitt
Journal: BMJ (1993)

standard that centres could embellish as they wished.This advanced life support course was piloted in 1992 and is now available to centres that conform with the requirements.Advertisements often state that courses conform to the guide- lines of the European and British Resuscitation Councils.However, some centres fail to satisfy the standards laid down for the new advanced life support course.The Resuscitation Council (UK) has therefore agreed to approve on request every course that satisfies the advanced life support requirements.These courses will be given a number that can be checked with the coordinator at our London office and successful participants on the courses will be entitled to receive a certificate from the Resuscitation Council.A H SWAIN ANTHONYJ HANDLEY Resuscitation Council (UK), London WIP 5AHAlcohol not a predictor of peripheral oedema in chronic bronchitis EDrroR,-Ronald Jalleh and colleagues conclude that alcohol consumption is an important independent predictor of peripheral oedema in patients with chronic bronchitis and emphysema by an unknown pathological mechanism.'I wish to suggest two possible explanations, which I believe are inadequately touched on by the authors.The patients with the higher alcohol intake in the study are more likely to develop cirrhosis and cardiomyopathy, both of which are associated with the development of oedema.The investigators state that patients had no evidence of liver or ischaemic heart disease.Confident exclusion of the presence of both conditions, however, relies on the correct choice of investigation performed.Classical clinical signs associated with cirrhosis may be absent with little disturbance in biochemical tests of liver function despite established histological changes on biopsy.2Similarly, the absence of evidence of ischaemic heart disease is less important than a measure of the degree of left ventricular dysfunction present in both study groups.Clarification by the authors of the type of assessment of liver and cardiac status is required before any conclusions can be made about the effect of alcohol on hypoxia.
P253 Obstructive sleep apnoea syndrome: Patients’ experience of the driver and vehicle licensing agency: Abstract P253 Table 1.
Authors: M Mason, N Oscroft, M Davies, T Quinnell, I Smith
Journal: Thorax (2013)

<h3>Introduction</h3> Driver’s licence holders have a legal obligation to inform the Driver and Vehicle Licensing Authority (DVLA) if diagnosed with Obstructive Sleep Apnoea Syndrome (OSAS). This requirement may cause considerable anxiety but few data are available to advise patients on the likely outcomes following such notification. <h3>Methods</h3> Patients diagnosed with OSAS and offered CPAP between 1<sup>st</sup> October 2009 and 31<sup>st</sup> March 2010 were surveyed anonymously and asked to report on: a) symptoms of sleepiness whilst driving before and after treatment; b) if they recalled being given advice about contacting the DVLA by healthcare professionals; c) whether they contacted the DVLA; d) the response of the DVLA if notified. The survey was performed between 1<sup>st</sup> June and 31<sup>st</sup> August 2010. To provide a description of the population surveyed 67 (10%) case notes were chosen at random from the population surveyed, reviewed and descriptive data extracted. <h3>Results</h3> Six hundred and seventy three patients were surveyed and 297 (44%) responded. 92% were category B licence holders. The data outlining the surveyed population are in Table 1. Sixty percent and 16% respectively reported no and moderate to severe sleepiness whilst driving, prior to treatment. Two hundred and six patients (69%) recalled being given advice about driving by a health care professional and of those 161 patients (78%) had informed the DVLA of their diagnosis. In total 197 patients (66%) had informed the DVLA of their OSAS. The DVLA asked 8% (16/197) to stop driving temporarily of which 80/197 contacted the DVLA prior to starting treatment. Five patients (2.5%) were deemed not fit to drive by the DVLA in the long term. The mean (SD) time for the DVLA to reach a decision was 29 (33) days. <h3>Conclusion</h3> In summary, recognising its limits, in particular the risk of responder bias, this survey shows most OSAS patients offered CPAP do not experience problems with driving licence retention if they contact the DVLA. The DVLA infrequently ask patients to stop driving. Approximately one third of patients had not informed the DVLA of their OSAS during the timeframe of this survey.
Common gene expression strategies revealed by genome-wide analysis in yeast
Authors: José García-Martínez, Fernando González-Candelas, José E Pérez-Ortín
Journal: Genome biology (2007)

Gene expression is a two-step synthesis process that ends with the necessary amount of each protein required to perform its function. Since the protein is the final product, the main focus of gene regulation should be centered on it. However, because mRNA is an intermediate step and the amounts of both mRNA and protein are controlled by their synthesis and degradation rates, the desired amount of protein can be achieved following different strategies. In this paper we present the first comprehensive analysis of the relationships among the six variables that characterize gene expression in a living organism: transcription and translation rates, mRNA and protein amounts, and mRNA and protein stabilities. We have used previously published data from exponentially growing Saccharomyces cerevisiae cells. We show that there is a general tendency to harmonize the levels of mRNA and protein by coordinating their synthesis rates and that functionally related genes tend to have similar values for the six variables. We propose that yeast cells use common expression strategies for genes acting in the same physiological pathways. This trend is more evident for genes coding for large and stable protein complexes, such as ribosomes or the proteasome. Hence, each functional group can be defined by a 'six variable profile' that illustrates the common strategy followed by the genes included in it. Genes encoding subunits of protein complexes show a tendency to have relatively unstable mRNAs and a less balanced profile for mRNA than for protein, suggesting a stronger regulation at the transcriptional level.
Towards Complete and Accurate Reporting of Studies of Diagnostic Accuracy: The STARD Initiative
Authors: Patrick M. Bossuyt, Johannes B. Reitsma, David E. Bruns, Constantine A. Gatsonis, Paul P. Glasziou, Les M. Irwig, Jeroen G. Lijmer, David Moher, Drummond Rennie, Henrica C.W. de Vet
Journal: Annals of Internal Medicine (2003)

Background: To comprehend the results of diagnostic accuracy studies, readers must understand the design, conduct, analysis, and results of such studies. That goal can be achieved only through complete transparency from authors. Objective: To improve the accuracy and completeness of reporting of studies of diagnostic accuracy in order to allow readers to assess the potential for bias in the study and to evaluate its generalizability. Methods: The Standards for Reporting of Diagnostic Accuracy (STARD) steering committee searched the literature to identify publications on the appropriate conduct and reporting of diagnostic studies and extracted potential items into an extensive list. Researchers, editors, methodologists and statisticians, and members of professional organizations shortened this list during a 2-day consensus meeting with the goal of developing a checklist and a generic flow diagram for studies of diagnostic accuracy. Results: The search for published guidelines on diagnostic research yielded 33 previously published checklists, from which we extracted a list of 75 potential items. The consensus meeting shortened the list to 25 items, using evidence on bias whenever available. A prototypical flow diagram provides information about the method of patient recruitment, the order of test execution, and the numbers of patients undergoing the test under evaluation, the reference standard, or both. Conclusions: Evaluation of research depends on complete and accurate reporting. If medical journals adopt the checklist and the flow diagram, the quality of reporting of studies of diagnostic accuracy should improve to the advantage of the clinicians, researchers, reviewers, journals, and the public. *For members of the STARD Group, see Appendix.
Ileocolonoscopic Diagnosis of Coeliac Disease
Authors: N. Sundar, A. Mukhtar, I. A. Finnie
Journal: Endoscopy (2003)

Routine examination of the terminal ileum during colonoscopy can provide useful information [1], but remains optional depending upon various factors including the discretion of the endoscopist and difficulty with other aspects of examination. We encountered a case where ileoscopy and biopsy resulted in a prompt diagnosis of coeliac disease.
From the Cave of Blood
Authors: Jackie Bartley
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ON THE MURMURS IN DILATED HEARTS AND THEIR EXPLANATIONS
Authors: S. West
Journal: BMJ (1914)

DILATATION of the heart is a common condition, easily ,recognized by physical signs.Murmurs are frequently associated with dilatation and are due to it, for they come and go with it.They mav be therefore very properly described as dilatation murmurs."How thev are produced is a problem upon which opinions differ, and it is to some points connected with this problem that I propose to address myself.I. Itnay simplify the question if we consider first the conditions under wllich murmnurs occur in dilated vessels, arteries, and veins.Murmurs are audible eddies."The most marked mnurmurs are often said to be due to a jet," but the jet only causes violent eddies.It is very extraordinary that the blood circulates tlhrouglh the normual vessels and heart without prodtucing mlurmiiurs.Eddies represent loss of power.The absence of murmurs shows the woniderful physiological adjustmiient of the vessels to the blood which .passes through tllem, so that, in spite of all the twists and turns the blood has to make, no eddies are produced.It is no wonder that alterations in the vessels should cause eddies and murmurs.The wonder is that they are not more common.The conditions under which eddies form fall into two groups according as the blood is passing: (A) Into or out of a dilatation of the vessel, or (B) through a constriction in it.For the eddies to be audible they must be sufficiently forcible, so that they will depend upon the force ofthe circulation.This explains why these murmurs vary in intensity at different times, wlhy they come and go, and sometimes even disappear.A. (a) Of the forms in which dilatation is the prominent change the simplest is that known as mimic aneurysm.
Hepatocyte transplantation activates hepatic stellate cells with beneficial modulation of cell engraftment in the rat
Authors: Daniel Benten, Vinay Kumaran, Brigid Joseph, Jörn Schattenberg, Yury Popov, Detlef Schuppan, Sanjeev Gupta
Journal: Hepatology (2005)

We investigated whether transplanted hepatocytes interact with hepatic stellate cells, as cell-cell interactions could modulate their engraftment in the liver. We transplanted Fischer 344 rat hepatocytes into syngeneic dipeptidyl peptidase IV-deficient rats. Activation of hepatic stellate cells was analyzed by changes in gene expression, including desmin and alpha-smooth muscle actin, matrix proteases and their inhibitors, growth factors, and other stellate cell-associated genes with histological methods or polymerase chain reaction. Furthermore, the potential role of hepatic ischemia, Kupffer cells, and cytokine release in hepatic stellate cell activation was investigated. Hepatocyte transplantation activated desmin-positive hepatic stellate cells, as well as Kupffer cells, including in proximity with transplanted cells. Inhibition of Kupffer cells by gadolinium chloride, blockade of tumor necrosis factor alpha (TNF-alpha) activity with etanercept or attenuation of liver ischemia with nitroglycerin did not decrease this hepatic stellate cell perturbation. After cell transplantation, soluble signals capable of activating hepatic stellate cells were rapidly induced, along with early upregulated expression of matrix metalloproteinases-2, -3, -9, -13, -14, and their inhibitors. Moreover, prior depletion of activated hepatic stellate cells with gliotoxin decreased transplanted cell engraftment. In conclusion, cell transplantation activated hepatic stellate cells, which, in turn, contributed to transplanted cell engraftment in the liver. Manipulation of hepatic stellate cells might provide new strategies to improve liver repopulation after enhanced transplanted cell engraftment.
Abstract 3252: Potent Aurora kinase inhibitors based on a pyrimidine scaffold: Synthesis, SAR and X-ray crystallography studies
Authors: Yunting Luo, Mathew Martin, Robert Kendig, Roberta Pireddu, Hua Yang, Stephane Betzi, Wesley Books, Huidong Yu, Ernst Schonbrunn, Nicholas Lawrence, Jin Cheng, Said Sebti, Harshani Lawrence
Journal: Cancer Research (2011)

Abstract Aurora kinases belong to the serine/threonine subclass of kinases involved in the regulation of mitosis. Out of the three isoforms of Aurora kinases; Aurora A, B and C, studies have shown Aurora A and B are up-regulated in many cancers including breast and colorectal cancers. Deregulated Aurora kinase activity has been linked to genetic instability, defects in centrosome function, spindle assembly, chromosome alignment and cytokinesis, all of which can lead to tumorigenesis. Inhibition of Aurora kinase A and B is emerging as target-based therapy in cancer treatment. HLM-8598 was identified from our in-house chemical library as a potent and highly selective inhibitor for Aurora A (IC50 value of 0.073 ± 0.002 μM) over Aurora B (IC50 = 5.4 ± 1.8 μM). HLM-8598 with pyrimidine scaffold represents 3-4 points of diversity for focused library synthesis. X-ray crystallography studies of HLM-8598 bound to Aurora A confirmed HLM-8598 is a type-1 kinase inhibitor that interacts with the ATP binding site of the enzyme. Synthetic modifications around HLM-8598 and focused library synthesis was carried out to explore structure activity relationship studies. The HLM-8598-Aurora A structure assisted the generation of new analogs with improved affinity (IC50 = 40 nM). The synthesis of HLM-8598 analogs, structure activity relationship studies along with X-ray crystallography will be discussed as a part of our efforts to identify Aurora kinase inhibitors. We will discuss the use of kinase structural elements to rationally guide compound synthesis and improve design strategy. The activity of this class of compounds in cells and animal models will be discussed as Aurora inhibitors as potential anti-cancer agents. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3252. doi:10.1158/1538-7445.AM2011-3252