tbuckley/cabot-search huggingface dataset:
Abstract LB-77: The Met receptor tyrosine kinase drives signaling through EGFR and ErbB3 in Met-amplified non-small-cell lung cancer
Authors: Yaakov E. Stern, Andrea Z. Lai, Morag Park
Journal: Cancer Research (2014)

Abstract Receptor tyrosine kinases are canonically activated by dimerization induced by the binding of a cognate ligand. This leads to autophosphorylation of the receptor molecules by their intrinsic kinase domains and the recruitment of intracellular protein complexes to initiate signaling. In many human cancers, receptor tyrosine kinases are aberrantly activated to promote proliferative signaling, thus driving tumor growth. The MET proto-oncogene is amplified in approximately 5% of non-small-cell lung cancers (NSCLC), a disease in which aberrant signaling through the epidermal growth factor receptor (EGFR) or the anaplastic lymphoma kinase is known to be oncogenic. The Met receptor tyrosine kinase is overexpressed and constitutively active in cell lines derived from MET-amplified tumors, and Met activity is required for proliferation. Furthermore, Met activity is sufficient to promote the phosphorylation of EGFR and its homologs ErbB2 and ErbB3 in the presence of inhibitors targeting EGFR, ErbB2, and Src family kinases. We show that Met utilizes the EGFR, ErbB2 and ErbB3 proteins as scaffolds to broaden downstream oncogenic signaling and promote cancer cell proliferation. The contribution of EGFR and its homologs to Met signaling in NSCLC will be presented with a focus on ErbB family kinases required for proliferation in MET-amplified NSCLC. Understanding the mechanisms by which Met drives proliferative signaling in NSCLC will become crucial as Met-targeted therapies become available in the clinic. Citation Format: Yaakov E. Stern, Andrea Z. Lai, Morag Park. The Met receptor tyrosine kinase drives signaling through EGFR and ErbB3 in Met-amplified non-small-cell lung cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-77. doi:10.1158/1538-7445.AM2014-LB-77
IMPACT REGISTRY: FIRST REVIEW OF COMMUNITY PRACTICE WITH RESPECT TO AORTIC AND PULMONARY VALVULOPLASTY
Authors: John W.M. Moore, Robert Vincent, Robert Beekman, Lisa Bergersen, Lee Benson, Ralf Holzer, Kathy Jenkins, Richard Ringel, Jonathan Rome, Kristina McCoy, Gerard Martin
Journal: Journal of the American College of Cardiology (2013)
Foundations Join to Help End Health Care Barriers
Authors: Marsha F. Goldsmith
Journal: JAMA (1993)

A NEW private-sector attempt to address the disparities that exist in the use and quality of health care services enjoyed by various groups in the United States is set to begin this week.  Opening Doors: A Program to Reduce Sociocultural Barriers to Health Care is a $5.5-million joint effort made by the Robert Wood Johnson Foundation, Princeton, NJ, and the Henry J. Kaiser Family Foundation, Menlo Park, Calif. The national program will provide grants for demonstration and research projects that are to explore ways of improving access to maternal, child, and reproductive health services.  The projects, whether conducted by community groups, health care organizations, or government agencies, will seek to comprehend and compensate for recognized but so far unremedied barriers to health care. Among the difficulties in providing medical and preventive health services to people across racial, ethnic, and socioeconomic lines are cultural differences between those who provide care and
Expression of the Endothelin Axis in Noninvasive and Superficially Invasive Bladder Cancer: Relation to Clinicopathologic and Molecular Prognostic Parameters
Authors: Elke Eltze, Peter J. Wild, Christian Wülfing, Ellen C. Zwarthoff, Maximilian Burger, Robert Stoehr, Eberhard Korsching, Arndt Hartmann
Journal: European Urology (2008)
Carbon Monoxide, Smoking In Automobiles, and in Haylofts
Authors: Horace E. Campbell
Journal: JAMA (1969)

<h3>To the Editor:—</h3> In his letter to the editor (<b>206</b>:1308, 1968), Dr. Bachman refers to everything that smoking might do to cause a traffic accident except the matter of carbon monoxide. This is presumably because the California study referred to states. "Drugs and carbon monoxide were not significant primary factors." Dr. Anne L. Davis states, "For example, the smoking of 30 cigarettes per day is estimated to provide a 20-25 fold greater exposure to carbon monoxide than would be experienced in the ambient air of Pasadena (Calif) by non-smokers." Fairly continuous smoking in an ill-ventilated closed car in the winter-time with a relatively minor leak in the motor exhaust system may be expected to be a serious<i>secondary</i>factor in fatal car crashes even though the carboxyhemoglobin determinations may not reveal a<i>primary</i>factor. lation than
Estrogen-Replacement Therapy — Help or Hazard?
Authors: Martin M. Quigley, Charles B. Hammond
Journal: New England Journal of Medicine (1979)

FEW controversies in the practice of medicine have generated as much discussion as has the role of estrogen-replacement therapy in the climacteric woman. The literature is replete with articles about the potentially beneficial effects of estrogen treatment and the potentially detrimental effects, such as adenocarcinoma of the endometrium. We shall attempt to place in perspective our current understanding of estrogen-replacement therapy and to make recommendations about its use.Although the term "menopause" refers to the specific biologic event of the last menstrual period, the term "climacteric" encompasses the years between the onset of premenopausal ovarian dysfunction and the end of . . .
Relationship Between the Plasma Level of Diphenylhydantoin Sodium and Its Cardiac Antiarrhythmic Effects
Authors: J. THOMAS BIGGER, DONALD H. SCHMIDT, HENN KUTT
Journal: Circulation (1968)

The effect of diphenylhydantoin sodium (DPH, Dilantin) on a variety of arrhythmias was studied in relation to its plasma levels. DPH was administered in one of three ways: (1) multiple intravenous doses, (2) single intravenous doses, and (3) oral doses. Ventricular arrhythmias occurring in many clinical conditions and atrial tachycardia, particularly if caused by digitalis excess, responded well to treatment with DPH. Three fourths of the responsive arrhythmias were abolished at plasma levels of DPH of 10 to 18 µg/ml. In most cases a critical, effective plasma level could be demonstrated; this level had to be exceeded in order to suppress the arrhythmia being treated. A method of rapidly effective oral therapy of arrhythmias with diphenylhydantoin is described, and a method of transition from intravenous to oral therapy is demonstrated. The antiarrhythmic action of diphenylhydantoin was accompanied by neither depression of sinoatrial nodal activity nor atrioventricular or intraventricular conduction disturbances, but was accompanied by a shortening of the Q-T interval. Hypotension accompanying the intravenous use of this drug was minimized by administration of the full dose in increments.
Analysis of Early-Phase Insulin Responses in Nonobese Subjects With Mild Glucose Intolerance
Authors: Hiroko Yoneda, Hiroshi Ikegami, Yoshihiro Yamamoto, Eiji Yamato, Tepyon Cha, Yoshihiko Kawaguchi, Yasuhiro Tahara, Toshio Ogihara
Journal: Diabetes Care (1992)

To study the possible contribution of a B-cell defect in the development of glucose intolerance in nonobese subjects.There were 41 normal, nondiabetic subjects; 18 subjects with IGT; and 21 patients with NIDDM. All subjects were nonobese (BMI < 27 kg/m2). Insulin secretory responses to an OGTT, IVGTT, and GST were studied.Early-phase insulin responses to OGTT and IVGTT were decreased in subjects with IGT to levels comparable with those in NIDDM patients, whereas the response to GST was preserved in the subjects with IGT compared with NIDDM patients. The insulinogenic index of OGTT correlated well (r = 0.78) with early-phase insulin response to IVGTT, suggesting that the insulinogenic index in OGTT is related to the early-phase insulin response to IVGTT in nonobese subjects.Impaired early-phase insulin response to glucose was associated with mild glucose intolerance, suggesting the importance of impaired insulin secretion in the development of glucose intolerance in nonobese subjects.
Clostridium difficile in association with sporadic diarrhoea.
Authors: R P Brettle, I R Poxton, J M Murdoch, R Brown, M D Byrne, J G Collee
Journal: BMJ (1982)

A total of 154 patients admitted to an infectious diseases unit were included in a year's prospective survey of sporadic diarrhoeal disease. Stools from 19 of them yielded Clostridium difficile, generally on more than one occasion. Twelve of these patients were assessed as having a severe or moderately severe gastrointestinal illness: Cl difficile was the only pathogen isolated from 10 of them, and two had an associated salmonella infection. Seven had had a recent course of antibiotics, but five had not taken antibiotics. Faeces from seven patients with moderate or mild gastrointestinal illness yielded Cl difficile, and two of these patients also had an associated salmonella infection. Two patients in this group had no antibiotic history. From these findings, the occurrence of C difficile in faeces could not be described as antibiotic-associated. Faecal Cl difficile cytotoxin was detected in only six patients, and generally at low levels. In such patients a more relevant pathogenic index might take account of the numbers of Cl difficile present and of their toxigenic potential.
Significance of tartrazine sensitivity in chronic urticaria of unknown etiology
Authors: Guy A. Settipane, Francis H. Chafee, I.Marshall Postman, Macy I. Levine, James H. Saker, Richard H. Barrick, S.Scott Nicholas, Howard J. Schwartz, Richard W. Honsinger, Donald E. Klein
Journal: Journal of Allergy and Clinical Immunology (1976)
Occupational asthma induced by cephalosporins
Authors: J. Sastre, S. Quirce, A Novalbos, M Lluch-Bernal, C Bombín, A Umpiérrez
Journal: European Respiratory Journal (1999)

A 20-yr-old pharmaceutical worker who developed attacks of shortness of breath and wheezing 9 months after beginning work on a process in which cefadroxil powder was bottled or encapsulated will be described. Skin test with cefaxodril was negative. Baseline spirometry and methacholine inhalation test were normal. A controlled bronchial challenge test was carried out in a closed-circuit system with assessment of respirable dust concentration. Exposure to cefadroxil powder at a mean concentration of 10 mg x m(-3) for 10 min elicited an isolated immediate asthmatic response, but no response was observed to control challenge with lactose. Single-blind oral challenge test with amoxicillin up to 500 mg was well tolerated, whereas the oral challenge with cephalexin (25 mg) elicited an immediate asthmatic response. This patient had developed occupational asthma caused by inhalation of cefadroxil as confirmed by specific inhalation test. Since she tolerated oral amoxicillin, a synthetic penicillin with the side-chain identical to that of cefadroxil, it seems that she may be sensitized to the dihydrothiazine ring of cephalosporins.
Aberrant Forms of Bacteria and Fungi in Human Disease.
Authors: Donald B. Louria
Journal: Annals of Internal Medicine (1969)

s1 May 1969Aberrant Forms of Bacteria and Fungi in Human Disease.Donald B. Louria, M.D., F.A.C.P., Theresa Kaminski, M.A.Donald B. Louria, M.D., F.A.C.P.Search for more papers by this author, Theresa Kaminski, M.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-5-1090_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIncreasing evidence points to the importance of transitional and L forms in the persistence of infections in patients whose routine cultures fail to demonstrate organisms in conventional form. We have observed six such cases: [1] A 44-year-old man developed fulminating abdominal-wall cellulitis and metastatic abscesses on his wrist. Cultures of blood and the lesion grew L forms of a corynebacterium. [2] A 30-year-old man had rheumatic heart disease and 9 months of intermittent fever. Routine cultures were negative, butStaphylococcus albusand transitional forms of alpha streptococci grew in hypertonic media. Antibiotic treatment was successful. [3] A 46-year-old man with... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Donald B. Louria, M.D., F.A.C.P.; Theresa Kaminski, M.A.Affiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1969Volume 70, Issue 5Page: 1090-1090KeywordsAbscessesAntibioticsBacteriaBloodCardiovascular therapyCellulitisFeversLesionsStaphylococcus ePublished: 1 December 2008 Issue Published: 1 May 1969 PDF downloadLoading ...
ANNULAR PANCREAS
Authors: Julius Brant
Journal: JAMA (1960)

The term annular  denotes a condition whereby a part of the pancreas forms a more or less complete ring around the second portion of the duodenum causing obstruction of varying degree. This entity was first described by Tiedeman in 1818. The condition is not common; about 88 1 cases are described in the literature in patients ranging in age from 2 days to 74 years. 2 The condition may be symptomless, if obstruction is incomplete, and may be found accidentally at autopsy or at surgery when other pathology was suspected. It is important to think of this condition when obstruction occurs high in the gastrointestinal tract in children or when vague epigastric symptoms present themselves in an adult.  Embryologically the pancreas develops from two sites, the ventral and dorsal anlagen, each with its duct arising from the primitive intestine which later forms the second portion of the duodenum. 3
Hospital-Based Influenza Vaccination Programs
Authors: Richard Snow
Journal: JAMA (1996)

<h3>To the Editor.</h3> —Vaccination against influenza has proven effective in reducing influenza-related hospitalizations and deaths among high-risk populations. A recent meta-analysis estimated that vaccine efficacy was 50% for reducing hospitalizations among vaccinated individuals during epidemic years.<sup>1</sup>Despite these findings, influenza vaccination is underused, with recent estimates suggesting that only 52% of high-risk individuals received vaccinations during the 1993 season.<sup>2</sup>In 1995, the Health Care Financing Administration provided the nation's professional review organizations with beneficiary-level data on influenza vaccination.<sup>3</sup>Professional review organizations are using this data to develop hospital-, community-, and physician-based projects that will enhance vaccination rates. To evaluate missed opportunities to vaccinate elderly patients, we determined influenza vaccination rates occurring in a cohort of individuals hospitalized during the 1994 vaccination season in Ohio. We used influenza vaccination billing data and information obtained from the dataset containing all Medicare hospitalizations in the state. From October 1 through
Increasing peripapillary atrophy is associated with progressive glaucoma
Authors: Hideya Uchida, Seyda Ugurlu, Joseph Caprioli
Journal: Ophthalmology (1998)

ObjectiveThis study aimed to determine the incidence and degree of progression of peripapillary atrophy in progressive and nonprogressive glaucoma.Study designA retrospective cohort study.ParticipantsA total of 75 eyes of 75 patients were examined.Main outcome measuresQualitative assessment of optic disc, peripapillary atrophy, and visual field change was performed by three experienced, masked, independent observers.MethodsRim-disc area ratio and peripapillary atrophy-disc area ratio were measured at baseline and follow-up with computer-aided planimetry.ResultsAmong 75 eyes studied with an average duration of follow-up of 8 years (range, 4–19 years), 33 (44%) showed progressive optic disc damage. Twenty-one (64%) of 33 eyes with progressive disc damage showed peripapillary atrophy progression, and 7 (17%) of 42 eyes without progressive disc damage showed peripapillary atrophy progression; this difference was significant (P < 0.01). In groups with and without peripapillary atrophy, no statistically significant differences were found for mean intraocular pressure, baseline rim-disc area ratio, or baseline peripapillary atrophy-disc area ratio. However, optic disc progression and visual field progression were statistically more frequent in the group with peripapillary atrophy progression (75% and 54%, respectively) than in the group without peripapillary atrophy progression (26% and 11%, respectively) (P < 0.01). There was a statistically significant correlation between measurements of peripapillary atrophy area increase and disc rim loss over time (r = −0.35, P = 0.002).ConclusionProgression of peripapillary atrophy is associated with progressive optic disc damage and progressive visual field loss in glaucoma and may be used as a marker for progressive glaucomatous damage.
Biliary stents: models and methods for endoscopic stenting
Authors: J.-M. Dumonceau, D. Heresbach, J. Devière, G. Costamagna, U. Beilenhoff, A. Riphaus
Journal: Endoscopy (2011)

Biliary stenting is widely used to palliate malignant obstruction or to treat benign biliary diseases. Recently, the most important changes have related to self-expandable metal stents (SEMSs), which are now available in a wide variety of designs, and to treatment techniques. This article is part of a combined publication that expresses the current view of the European Society of Gastrointestinal Endoscopy (ESGE) about endoscopic biliary stenting: a technology review describes the stent models and stenting techniques, and a separate clinical guideline states the evidence and recommendations regarding stenting.
Postponement of Death
Authors: Pang L. Man
Journal: JAMA (1990)

<h3>To the Editor.—</h3> I read the article "Postponement of Death Until Symbolically Meaningful Occasions"1 with great interest. I was born and raised in China, and I personally witnessed the postponement of death by family members and the sick alike. Family members may seek the postponement for certain occasions, eg, festivals or to avoid the unlucky dates of the lunar calendar. In the lunar calendar, some dates are considered to be black, or unlucky. The sick prefer not to die on those days, believing that they will suffer a worse life after death. The other cause of postponement of death is that the dying person wants to see the fulfillment of a wish; he or she may long eagerly for a special beloved one to come home to say goodbye and take care of the burial ceremony. As soon as the beloved one arrives and utters some kind words, the sick
Detection of Cyclin B1 Expression in G1-Phase Cancer Cell Lines and Cancer Tissues by Postsorting Western Blot Analysis
Authors: Manli Shen, Yongdong Feng, Chun Gao, Deding Tao, Junbo Hu, Eddie Reed, Qingdi Q. Li, Jianping Gong
Journal: Cancer Research (2004)

Abstract Protein complex of cyclin B1 and cyclin-dependent protein kinase 1 induces phosphorylation of key substrates that mediate cell cycle transition during the G2-M phase. It is believed that cyclin B1 accumulates in the S phase of the cell cycle and reaches the maximal level at mitosis but is absent in G1-phase cells. In the present study, we demonstrated that cyclin B1 was expressed in the arrested G1-phase MOLT-4 lymphocyte leukemia cells and in G1 phase T-7 transitional tumor cells, as determined by flow cytometry. In addition, we showed that cyclin B1 was detected in the G1 phase in breast cancer cells from patient tissues and in lymphocytes from patients with leukemia. These findings were confirmed for the first time by postsorting Western blot analysis and by confocal microscopy. Furthermore, by using postsorting Western blotting, we found that cyclin B1 was expressed in different time-window sections of the G1 phase under different conditions. For the asynchronously growing T-7 cells, cyclin B1 was detected in early G1 phase, whereas in MOLT-4 cells arrested in G1-S phase, cyclin B1 was mainly detected in late G1 phase. We propose that the cyclin B1 expressed in the G1 phase may differ from that expressed in the G2-M phase, and that this unscheduled type of cyclin B1 may play an important role in tumorigenesis and apoptosis.
Beyond a Dworkinean View on Autonomy and Advance Directives in Dementia. Response to Open Peer Commentaries on “Would We Rather Lose Our Life Than Lose Our Self? Lessons From the Dutch Debate on Euthanasia for Patients With Dementia”
Authors: Cees M. P. M. Hertogh, Marike E. de Boer, Rose-Marie Dröes, Jan A. Eefsting
Journal: The American Journal of Bioethics (2007)

But it must be said from the outset that a disease is never a mere loss or excess—that there is always a reaction, on the part of the affected organism or individual, to restore, to replace, to com...
Are serum bile salt concentrations raised in hyperlipidaemia?
Authors: G J Beckett, J G Douglas, N D Finlayson, I W Percy-Robb
Journal: Gut (1980)

We have studied serum fasting and postprandial primary bile salt concentrations in a group of 10 consecutive hyperlipidaemic subjects. The efficiency of hepatic bile salt clearance in the same subjects was aslo studied using an injected dose of sodium glycocholate. No increase in serum fasting or postprandial concentrations of the primary bile salts were observed and hepatic bile salt clearance was only marginally abnormal in one subject. The presence of hyperlipidaemia does not invalidate the use of serum conjugated bile salt analysis for the detection of liver diseases.
Three-dimensional analysis of regional myocardial function in response to nitroglycerin in patients with coronary artery disease
Authors: Shigetake Sasayama, Hiroshi Nonogi, Masatoshi Fujita, Tsunetaro Sakurai, Akira Wakabayashi, Chuichi Kawai, Shigeru Eiho, Michiyoshi Kuwahara
Journal: Journal of the American College of Cardiology (1984)
Renal replacement therapies in the aftermath of the catastrophic Marmara earthquake
Authors: Mehmet S. Sever, Ekrem Erek, Raymond Vanholder, Birsen Yurugen, Gulcin Kantarci, Mahmut Yavuz, Hulya Ergin, Semra Bozfakioglu, Serran Dalmak, M. Yasar Tulbek, Haluk Kiper, Norbert Lameire
Journal: Kidney International (2002)