Griseofulvin and Dysgeusia: Implications?
Authors: LANCE FOGAN
Journal: Annals of Internal Medicine (1971)

Letters and Comments1 May 1971Griseofulvin and Dysgeusia: Implications?LANCE FOGAN, M.D., MPHLANCE FOGAN, M.D., MPHSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-74-5-795 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A 31-year-old man was begun on griseofulvin (Grifulvin V®, produced by McNeil Laboratories, Inc.), 250 mg twice daily, for treatment of a chronic trichophyton infection on his feet. After 25 days of treatment the drug therapy was discontinued. Scrapings remained positive for hyphae, however, and 1 week later griseofulvin was reinstituted at 250 mg in the morning and 500 mg in the evening. Three weeks after beginning the second round of griseofulvin ingestion, dysgeusia developed. This disturbance in taste perception was characterized by the gradual awareness of a monotonous, singular taste or, better, tastelessness to all foods...References1. HENKINKEISERJAFFE RHI: Decreased taste sensitivity after D-penicillamine reversed by copper administration Lancet 2:1268-1271, 1967 CrossrefMedlineGoogle Scholar2. KEISERHENKINBARTTER HRF: Loss of taste during therapy with penicillamine. JAMA 203:381-383, 1968 CrossrefMedlineGoogle Scholar3. MCNEIL LABORATORIES, INC., Fort Washington, Pa., Clinical Research and Services Department: Personal communication, 1971 Google Scholar1. SCHECHTERHENKIN PR: Unpublished observations Google Scholar2. HENKINKEISERJAFFE RHI: Decreased taste sensitivity after D-penicillamine reversed by copper administration. Lancet 2:1268-1271, 1967 CrossrefMedlineGoogle Scholar3. HENKINBRADLEY RD: Regulation of taste acuity by thiols and metal ions. Proc Nat Acad Sci USA 62:30-37, 1969 CrossrefMedlineGoogle Scholar4. SCOTT P: Glossitis with complete loss of taste sensation during Dindevon treatment. Report of a case. New Zeal Med J 59:296, 1960 MedlineGoogle Scholar5. RABE F: Isolierte Ageusie. Ein neues Symptom als Nebenwirkung von Medikamenten. Nervenarzt 41:23, 1970 MedlineGoogle Scholar6. BOURLIERECENDRONRAPAPORT FHA: Action de l'acide acetylsalicylique sur la sensibilite au gout amer chez l'homme. Rev Franc Etude Clin Biol 4:380-382, 1959 MedlineGoogle Scholar7. HENKINHOYEKETCHAM RRA: Hyposmia following laryngectomy. Lancet 2:479-481, 1968 CrossrefMedlineGoogle Scholar8. HENKINSCHECHTERHOYE RPR: Idiopathic hypogeusia with dysgeusia, hyposmia and dysosmia: a new syndrome. J Amer Med Ass 1971, in press CrossrefGoogle Scholar9. HENKIN R: The metabolic regulation of taste acuity, in Olfaction and Taste, vol. III, edited by PFAFFMAN C. New York, Rockefeller University Press, 1970 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Resident in Neurology University Hospitals of Cleveland Cleveland, Ohio 44106 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByTreatments for smell and taste disorders: A critical reviewTaste and Appetite Loss in the AgedDrug-Induced Taste DisordersLoss of Taste, Smell, and Other Senses with AgeTaste and smell perception in the elderly: Effect of medications and diseaseMedication‐Induced Taste DisturbancesAntifungal agents: An overview. Part IDrug-Induced Taste DisordersThe initial evaluation of dysosmiaTaste and Smell in DiseaseMetal-binding characteristics of the parotid salivary protein gustinDrugs and NutritionDefects of taste and smell in patients with hypothyroidismFunktionspr�fungen und St�rungen des Geschmackssinnes 1 May 1971Volume 74, Issue 5Page: 795-796KeywordsDrug therapyFoodIngestionPerceptionTaste Issue Published: 1 May 1971 PDF DownloadLoading ...