tbuckley/cabot-search huggingface dataset:
The Roentgen Diagnosis of Diseases of the Alimentary Canal.
Authors: Russell D. Carman
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 19686: Cardioprotective Role of Paraoxonases in Heart Failure
Authors: David J Kennedy, Malory E Weber, Kristen M Westfall, Xi Wang, Diana Shih, Srinivasa T Reddy, Aldons J Lusis, Stanley L Hazen, W. H. Wilson Tang
Journal: Circulation (2014)

Paraoxonases isoforms 1, 2, and 3 (PON-1, -2, -3) constitute a family of calcium-dependent esterases which exhibit arylesterase, paraoxonase, and lactonase activities. Decreased serum PON activity is associated with increased oxidant stress and adverse clinical outcomes in the setting of heart failure (HF), yet whether decreased PON is mechanistically linked to HF is unclear. We tested the hypothesis that PON is cardioprotective in the following studies. First we measured PON expression in explanted human hearts. Both PON2 and PON3 protein and mRNA levels were significantly higher (>2 fold, p
Drug points: Thromboembolism associated with the new contraceptive Yasmin
Authors: Kees van Grootheest, Tom Vrieling
Journal: BMJ (2003)

Our centre, the Dutch spontaneous reporting system for adverse drug reactions, recently received five reports of thromboembolism as a suspected adverse drug reaction to the new oral contraceptive Yasmin (ethinylestradiol and drospirenone).

A 17 year old woman suddenly collapsed and died after taking the contraceptive for six months. Autopsy showed that she had had a massive pulmonary embolism. No obvious risk factors for thromboembolism, such as smoking, a period of long immobilisation, air flights, or concomitant medication, …
Abstract 11658: Riser Pattern is Associated With Mild Cognitive Impairment in Heart Failure Patients
Authors: Takahiro Komori, Kazuo Eguchi, Toshinobu Saito, Yoshioki Nishimura, Satoshi Hoshide, Kazuomi Kario
Journal: Circulation (2014)

Introduction: The riser pattern, an abnormal blood pressure (BP) pattern in which sleep BP exceeds awake BP, is a predictor of adverse cardiovascular outcomes. Although the riser pattern is associated with various factors, its significance in heart failure (HF) patients has not been established. HF patients often suffer from cognitive impairment (CI), but the relationship between the riser pattern and CI is not clearly understood. Hypothesis: We tested the hypothesis that the riser pattern is associated with mild CI, a form of brain damage that could develop to dementia. Methods: We performed the Mini-Mental State Examination (MMSE), ambulatory BP monitoring, echocardiography, and blood tests in 444 HF patients just before they left the hospital. Mild CI, a measure of cognitive function, was defined as a score &lt;26. Results: The mean age of the patients was 68±13 years; 61.5% were male; and 22.5% exhibited a riser pattern. The MMSE score was significantly lower in the Riser group than in the Non-riser group (23±5 vs 25±5, p&lt;0.01). In multivariable logistic regression analysis, a riser pattern was significantly associated with mild CI (odds ratio 2.07, 95% confidence intervals 1.19-3.61, p&lt;0.01) after adjusting for significant covariates. Conclusions: A riser pattern was associated with mild CI in HF patients. An abnormal circadian BP rhythm in HF patients is clinically significant as a potential indicator of subclinical brain damage.
Prognostic significance of the Ki-67-associated proliferative antigen in aggressive non-Hodgkin's lymphomas: a prospective Southwest Oncology Group trial
Authors: TP Miller, TM Grogan, S Dahlberg, CM Spier, RM Braziel, PM Banks, K Foucar, CR Kjeldsberg, N Levy, BN Nathwani
Journal: Blood (1994)
PROTECTIVE ACTION OF AUTOLOGOUS MARROW AGAINST NITROGEN MUSTARD TOXICITY
Authors: M M BLACK, F D SPEER, M L STONE
Journal: Annals of Internal Medicine (1959)

Article1 September 1959PROTECTIVE ACTION OF AUTOLOGOUS MARROW AGAINST NITROGEN MUSTARD TOXICITYMAURICE M. BLACK, M.D., FRANCIS D. SPEER, M.D., MARTIN L. STONE, M.D.MAURICE M. BLACK, M.D., FRANCIS D. SPEER, M.D., MARTIN L. STONE, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-3-517 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA principal limitation in the use of currently available cancer chemotherapy is bone marrow toxicity. The repeated use of drugs such as nitrogen mustard leads to progressive leukopenia, thrombocytopenia, anemia and, finally, marrow aplasia. This sequence of events is all too familiar to the clinician, who is often forced to choose between standing by helplessly and watching the cancer kill the patient, or repeating the use of drugs which may lead to a hemorrhagic diathesis and death.Various attempts have been made to minimize the exposure of the host tissues to nitrogen mustard by such manipulations as intra-arterial injections in...Bibliography1. BiermanShimkinMettierWeaverBerryWise HRMBSRJWCSP: Methyl-bis (beta-chlorethyl) amine in large doses in the treatment of neoplastic diseases, California Med. 71: 1-9, 1949. MedlineGoogle Scholar2. PortorMurray RAJE: Successful homotransplantation of rabbit bone marrow after preservation in glycerol at -72° C, Cancer Research 18: 117-119, 1958. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication January 19, 1959.From the Departments of Pathology and Obstetrics and Gynecology, New York Medical College, New York, N. Y.†Aided by grants from the Morris Morgenstern Foundation and the Schering Corporation.Requests for reprints should be addressed to Maurice M. Black, M.D., Professor of Experimental Pathology, New York Medical College, Flower and Fifth Avenue Hospitals, Fifth Avenue at 106th Street, New York 29, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNitrogen mustardsHigh-dose nitrogen mustard (HN2) with autologous nonfrozen bone marrow transplantation in advanced malignant melanomaHuman Tissue TransplantationNitrogen Mustards and Related Alkylating AgentsRadiation Chimeras 1 September 1959Volume 51, Issue 3Page: 517-525KeywordsAnemiaBone marrowCancer chemotherapyDrugsObstetrics and gynecologyToxicity ePublished: 1 December 2008 Issue Published: 1 September 1959 PDF downloadLoading ...
Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
Authors: Masao Mizuki, Regina Fenski, Hartmut Halfter, Itaru Matsumura, Rainer Schmidt, Carsten Müller, Wolfram Grüning, Karsten Kratz-Albers, Susanne Serve, Claudia Steur, Thomas Büchner, Joachim Kienast, Yuzuru Kanakura, Wolfgang E. Berdel, Hubert Serve
Journal: Blood (2000)
New Drug to Lower LDL Cholesterol
Authors: Rebecca Voelker
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis
Authors: Michio Onizawa, Shigeru Oshima, Ulf Schulze-Topphoff, Juan A Oses-Prieto, Timothy Lu, Rita Tavares, Thomas Prodhomme, Bao Duong, Michael I Whang, Rommel Advincula, Alex Agelidis, Julio Barrera, Hao Wu, Alma Burlingame, Barbara A Malynn, Scott S Zamvil, Averil Ma
Journal: Nature Immunology (2015)
Primary Care Geriatrics: A Case-Based Approach
Authors: Richard J. Ham, Philip D. Sloane, Gregg A. Warshaw
Journal: Annals of Internal Medicine (1992)

Principles & Practice: Primary Care. Demographics. Normal Aging. Illness & Aging. Assessment. The Health Care System. Minorities. Health Maintenance & Promotion. Nutrition. Pharmacotherapeutics. Rehabilitation. Ethics. Hospital Care. Institutional Care. Home Care. Terminal Care. The Major Syndromes. Confusion, Dementia and Delirium. Depression and Failure to Thrive. Dysmobility and Immobility. Dizziness. Falls and Falling. Incontinence. Clinical Problems: Perioperative Care. Elder Abuse. Alcoholism. Driving. Vision. Hearing. Sexuality. Sleep. The Mouth and Teeth. The Feet. The Skin. Pressure Sores. Diabetes Mellitus. Thyroid Disease. Osteoporosis. Estrogen Therapy. The Prostrate. Constipation. Hypertension. Congestive Heart Failure and Dysrhythmias. Myocardial Infarcation and Angina. Peripheral Vascular Disease. Stroke. Parkinson's Disease. Lower Respiratory Infections. Urinary Tract Infections. The Acute Abdomen. Polymyalgia Rheumatica. Hypothermia.
CARD15 mutations in Blau syndrome
Authors: Corinne Miceli-Richard, Suzanne Lesage, Michel Rybojad, Anne-Marie Prieur, Sylvie Manouvrier-Hanu, Renate Häfner, Mathias Chamaillard, Habib Zouali, Gilles Thomas, Jean-Pierre Hugot
Journal: Nature Genetics (2001)
Private company to sequence human genome
Authors: T. Rutter
Journal: BMJ (1998)

A private US company in partnership with a well known geneticist has announced that it can sequence the human genome much more rapidly and at considerably lower cost than the federal project that is now under way.

Dr J Craig Venter—a geneticist who in 1995 made headlines with the publication of the first full genome ever to be sequenced, the bacterium Haemophilus influenzae , and who is the president of the Institute for Genomic Sciences—has teamed up with Michael Hunkapiller, the president of the …
Abstract 19581: In-hospital Management and Outcomes in Patients with Myocardial Infarction and Non-obstructive Coronaries
Authors: Rosanna Tavella, Sivabaskari Pasupathy, Margaret Arstall, Derek Chew, Matthew Worthley, Christopher Zeitz, John Beltrame
Journal: Circulation (2014)

OBJECTIVE: To assess contemporary therapy and outcomes in patients with Myocardial Infarction and Non-Obstructive Coronary Arteries (MINOCA) compared to those who have myocardial infarction with obstructive CAD (MICAD). METHOD: The Coronary Angiogram Database of South Australia (CADOSA) Registry utilizes the CathPCI® Registry data elements and definitions, with data obtained by trained data collectors who capture all South Australian public hospital coronary angiograms. Results: In 2012, coronary angiography was performed in 1,176 myocardial infarct patients of whom 197 (11%) had MINOCA. Compared with MICAD patients, the MINOCA patients were significantly younger (64±13 vs. 59±15 years, p <0.01), more likely to be female (26% vs. 50%, p<0.01) and have depression (50% vs. 68%, p<0.01) but less likely to have diabetes (31% vs. 21%, p=0.2), dyslipidemia (60% vs. 49%, p<0.01) or smoke (37% vs. 27% p<0.01). Also in comparison to the MICAD patients, the MINOCA patients were less likely to receive secondary prev...
Abstract 13533: 1-Year Results of Paclitaxel-Coating Nitinol Stent Placement for Chronic Total Occlusion in the Femoropopliteal Artey
Authors: Naotaka Murata, Yoshimitu Soga, Yusuke Tomoi, Seiichi Hiramori, Yohei Kobayashi, Kei Ichihashi
Journal: Circulation (2014)

Introduction: The mid-term outcomes of paclitaxel-coating nitinol stent (Zilver PTx) placement for chronic total occlusion (CTO) in the femoropopliteal artery have not been assessed. Hypothesis: Zilver PTx placement for CTO in the femoropopliteal artey is reliable. Methods: All patients enrolled in this prospective, single center study underwent Zilver PTx placement for de novo or restenotic CTO and non-CTO in the superficial femoral and/or popliteal artery. Baseline and follow-up Rutherford classification and Ankle-brachial index (ABI) measurements were obtained. Follow-up was completed at 3, 6, 12 months. Results: There were 61 of CTO and 58 of non-CTO treated. Mean age was 74 ± 8 years and male was 82 % in overall. Patients characteristics and degree of lesion calcification was not different significantly between two groups. CTO group had a longer mean lesion length than non-CTO group (209 mm ± 93 mm vs 131 mm ± 87 mm, P &lt; .0001). Procedural success in both treatments was over 98 %. The operative complications were 3 cases in CTO group and 2 cases in non-CTO group. The primary patency of CTO group was significantly lower than non-CTO group in Kaplan-Meier estimate curves at 12 months (75 % vs 82 %, Log-rank P &lt; 0.05). There were no significant differences in event-free survival or freedom from target lesion revascularization in Kaplan-Meier estimate curves at 12 months (68 % vs 70 %; Log-rank P = 0.82, 63 % vs 65 %; Log-rank P = 0.47, respectively). Both groups experienced a significant improvement in Rutherford classification and ABI after treatment, and these improvements were sustained to 12-months follow-up. Based on multivariate analysis, CTO was the negative predictor for primary patency at 12 months (HR 2.37, 95 % CI 1.02 to 5.9, adjusted P &lt; 0.05). Conclusions: CTO influences negatively the primary patency of Zilver PTx placed in the femoropopliteal artery. However, Improvement of Rutherford classification and ABI at 12-months after CTO- intervention is sustained.
Methadone Regulations Overhauled
Authors: Brian Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P541: Natriuretic peptide inhibition of sarcolemmal atp-sensitive potassium channel in rat cardiomyocytes [Abstract]
Authors: D. S. Burley, C. D. Cox, K. T. Wann, Gary Francis Baxter
Journal: Cardiovascular Research (2012)

Purpose: Natriuretic peptides (NPs) administered during early reperfusion are protective in models of myocardial infarction. A previous study examining the endogenous components of B-type natriuretic peptide (BNP) protection of reperfused myocardium, implicated both sarcolemmal (s) KATP and mitochondrial (m) KATP channels. The indirect evidence characterising the relationship between BNP signalling and KATP was obtained using sulphonylurea receptor inhibitors in a rat isolated heart model of ischaemia-reperfusion injury. Here we seek to further examine the relationship between NPs and sKATP openings using single channel electrophysiology. Given our previous findings and the overarching consensus that cardioprotective autacoids open KATP channels, it was hypothesised that NPs elicit sKATP opening.

Methods: Cardiomyocyte isolation. Left ventricular cardiomyocytes were isolated from male Sprague-Dawley rat hearts subjected to enzymatic digestion with Liberase Blendzyme DL. Cardiomyocytes were cultured overnight in Medium 199, prior to patch clamp. Single channel patch clamp. Single channel recordings at room temperature (22°C) were made from cell attached patches bathed in Na+ Locke, pH 7.2. The recording pipette contained high KCl (140 mM), pH 7.2. Recordings (45 sec) were made over a range of patch potentials (0, -30, -60, -90, -120 mV), in the absence (control) and in the presence of bath applied BNP (10, 100 nM and 1 µM), pinacidil (200 µM) or pinacidil vehicle (DMSO, 0.25%). Recordings were also made with BNP and pinacidil applied concomitantly. Data are mean ± S.E.M.

Results: The current voltage relationship of sKATP under control conditions was linear at –ve patch potentials, the mean conductance being 52.9 ± 1.8 pS (n = 18 hearts, n = 35 cells). Pinacidil caused a four fold increase in sKATP open probability compared to control. Mean channel conductance in the presence of pinacidil was 59.9 ± 1.9 pS (n = 16 hearts, n = 44 cells). Interestingly BNP at all concentrations had negligible effects on sKATP open probability and unitary conductance. However, BNP at all concentrations and patch potentials inhibited pinacidil induced sKATP openings, restoring channel open probability to baseline.

Conclusion: These data illustrate the inhibitory effect of NP signalling on sKATP function in the cardiomyocyte under normoxia. They are concordant with the inhibitory effect of atrial NP on KATP in the pancreatic beta cell, but are in apparent conflict with the current cardioprotection paradigm. However, differential effects on sKATP and mKATP and the effects of hypoxia-reoxygenation require further exploration.
Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies
Authors: D Wormser, S Kaptoge, E Di Angelantonio, A M Wood, L Pennells, A Thompson, N Sarwar, Kizer, D A Lawlor, B G Nordestgaard, P Ridker, V Salomaa, J Stevens, M Woodward, N Sattar, R Collins, S G Thompson, G Whitlock, J Danesh
Journal: The Lancet (2011)
Reactions to the Events of September 11
Authors: Robert Rosenheck
Journal: New England Journal of Medicine (2002)

The author compared the average number of daily outpatient visits during the 19 working days before and after September 11 in different clinical subgroups and geographic locations (excluding weekends, holidays, and September 11 itself). Although the events of September 11 were profoundly traumatic for those directly involved and clearly distressing for others, they are not necessarily medically significant.
Abstract 17321: Race Differences in Hemodynamic Responses to Acute Mental Stress and the Role of Depressive Symptoms
Authors: Kobina A Wilmot, Ibhar Al Mheid, Ronnie Ramadan, Pratik M Pimple, Amit J Shah, Ayman Alkhoder, Malik Obideen, Michael Kutner, Qi Long, Tene` Lewis, Paolo Raggi, Douglas Bremner, Arshed A Quyyumi, Viola Vaccarino
Journal: Circulation (2014)

Introduction: Increased hemodynamic responses to psychological stress have been associated with adverse CAD events. African Americans (AA) have worse CAD outcomes than other groups. Heightened hemodynamic responses to stress may play a role. Our hypothesis was that AA would have higher hemodynamic reactivity to a standardized mental stress compared to Non-African Americans (NAA). Methods: We evaluated 574 patients (163 AA) with CAD, who underwent a standardized mental stress challenge. Hemodynamics were obtained at rest, during stress (speaking task), and during recovery. The rate-pressure product (RPP) was calculated as systolic blood pressure (SBP) x heart rate (HR). Hemodynamic reactivity was evaluated as the difference in RPP at rest and during stress. Depressive symptoms were measured with the Beck Depression Inventory-II (BDI). Results: As compared to NAA, AA patients were younger, had lower education and income, and higher prevalence of diabetes, obesity, hypertension, smoking, and depressive symptoms (BDI mean scores 9.8 vs. 7.6, p= 0.003). AA patients had higher blood pressure during all three periods (Table). However, hemodynamic reactivity with stress was significantly lower in AA than NAA (RPP reactivity 3114 vs 3620, p= 0.02). Adjusting for baseline RPP, age, gender and smoking did not substantially alter the association. However, after adjusting for depressive symptoms, the association was attenuated by 23% (p=0.16). BMI, diabetes and beta-blocker use had minimal additional explanatory role. In the final model, baseline RPP, depressive symptoms and BMI were significantly associated with a lower RPP reactivity (p&lt;0.01). Conclusion: AA patients with CAD, compared with NAA, have elevated blood pressure throughout mental stress, but tend to have blunted hemodynamic reactivity to stress. Depressive symptoms, which are more elevated among AA, play a role in this different response to stress and may be implicated in the higher CAD risk of this group.
Reduced Risk of Squamous Cell Carcinoma With Adequate Treatment of Vulvar Lichen Sclerosus
Authors: Susan M. Cooper, Nina Madnani, Lynnette Margesson
Journal: JAMA Dermatology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal