Thrombotic Thrombocytopenic Purpura and Hemolytic-Uremic Syndrome in HLA-Identical Siblings
Authors: Richard M. Hellman, Don V. Jackson, David H. Buss
Journal: Annals of Internal Medicine (1980)

Brief Reports1 August 1980Trifluoperazine Reversal of Secretory Diarrhea in Pancreatic CholeraMARK DONOWITZ, M. D., GRACE ELTA, M.D., STEPHEN ROBERT BLOOM, M.D., LARRY NATHANSON, M.D.MARK DONOWITZ, M. D.Search for more papers by this author, GRACE ELTA, M.D.Search for more papers by this author, STEPHEN ROBERT BLOOM, M.D.Search for more papers by this author, LARRY NATHANSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-93-2-284 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDiarrhea caused by excessive production of certain hormones by tumors is associated with conversion of the small intestine or colon from an absorbing into a secretory organ (1). Although treatment of diarrhea is most specifically aimed at the tumor, it is not always effective. Another approach is to stimulate intestinal absorption or inhibit the intestinal secretory processes by pharmacotherapy aimed directly at intestinal electrolyte transport processes. We report here a case of pancreatic cholera syndrome in a patient in whom diarrhea dramatically responded to pharmacotherapy with the phenothiazine trifluoperazine.A 53-year-old woman was originally diagnosed as having the pancreatic cholera...References1. BINDER H editor. Net fluid and electrolyte secretion: the pathophysiologic basis for diarrhea. In: Mechanisms of Intestinal Secretion. New York: Alan R. Liss, Inc.; 1979:1-16. Google Scholar2. GAGELCOSTANZADELELLIS RMR. Streptozocin-treated Verner-Morrison syndrome: plasma vasoactive intestinal peptide and tumor responses. Arch Intern Med. 1976;136:1429-35. CrossrefMedlineGoogle Scholar3. HOLMGRENLANGELONNROTH JSI. Reversal of cyclic AMP-mediated intestinal secretion in mice by chlorpromazine. Gastroenterology. 1978;75:1103-8. CrossrefMedlineGoogle Scholar4. RABBANIGREENOUGHHOLMGRENLONNROTH GWJI. Chlorpromazine reduces fluid-loss in cholera. Lancet. 1979;1:410-2. CrossrefMedlineGoogle Scholar5. ILUNDAINNAFTALIN AR. Role of Ca2+ -dependent regulator protein in intestinal secretion. Nature. 1979;279:446-8. CrossrefMedlineGoogle Scholar6. FIELD M. Intracellular mediators of secretion in the small intestine. See Reference 1, pp. 83-92. Google Scholar7. BOLTONFIELD JM. Ca ionophore-stimulated ion secretion in rabbit ileal mucosa: relation to actions of cyclic 3′, 5′-AMP and carbamylcholine. J Membr Biol. 1977;35:159-74. CrossrefMedlineGoogle Scholar8. FRIZZELL R. Active choloride secretion by rabbit colon: calcium-dependent stimulation by ionophore A23187. J Membr Biol. 1977;35:175-87. CrossrefMedlineGoogle Scholar9. DONOWITZASARKOFPIKE MNG. Calcium dependence of serotonin-induced changes in rabbit ileal electrolyte transport. J Clin Invest. In press. Google Scholar10. WOLFFBROSTROM DC. Properties and function of the calcium-dependent regulator protein. In: GREENGARD P, ROBISON GA, eds. Advances in Cyclic Nucleotide Research, vol. 11. New York: Raven Press; 1979:27-88. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Tufts-New England Medical Center Boston, Massachusetts Royal Postgraduate Medical School London England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDeficient activity of von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpuraAetiology and pathogenesis of thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome: the role of von Willebrand factor-cleaving proteaseClose relationship between systemic lupus erythematosus and thrombotic thrombocytopenic purpura in childhoodThrombotic MicroangiopathyRacial incidence of hemolytic-uremic syndromeHLA-DR53 protects against thrombotic thrombocytopenic purpura/adult hemolytic uremic syndromeInherited Hemolytic Uremic Syndrome in AdultsThrombotic microangiopathiesVasoactive Intestinal Peptide Secreting Tumors. Pathophysiological and Clinical CorrelationsThrombotic Thrombocytopenic PurpuraThrombotisch-thrombozytopenische PurpuraStudies of a patient with recurring thrombotic thrombocytopenic purpuraHemolytic-Uremic Syndrome: Current Concepts and ManagementThrombotic thrombocytopenic purpura in pregnancy 1 August 1980Volume 93, Issue 2Page: 284-285KeywordsCholeraColonDiarrheaDrug therapyHormonesPhenothiazineSmall intestine ePublished: 1 December 2008 Issue Published: 1 August 1980 PDF downloadLoading ...