tbuckley/cabot-search huggingface dataset:
Cardiac Metabolism in Cardiomyopathies.
Authors: V. E. Wendt
Journal: Annals of Internal Medicine (1962)

s1 April 1962Cardiac Metabolism in Cardiomyopathies.V. E. Wendt, M.D., S. Gudbjarnason, M.D., T. B. Stock, M.D., R. O. Hayden, M.D., F.A.C.P., M. Rothlin, M.D., R. J. Bing, M.D., F.A.C.P.V. E. Wendt, M.D.Search for more papers by this author, S. Gudbjarnason, M.D.Search for more papers by this author, T. B. Stock, M.D.Search for more papers by this author, R. O. Hayden, M.D., F.A.C.P.Search for more papers by this author, M. Rothlin, M.D.Search for more papers by this author, R. J. Bing, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-4-672_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMetabolism of the heart was studied in 31 patients with cardiac myopathy caused by progressive muscular dystrophy (PMD), thyrotoxicosis, and unknown causes. Arteriosclerotic, hypertensive, and rheumatic heart diseases were excluded. Several of the patients suffered from congestive heart failure. The coronary sinus was intubated and lactate, pyruvate, glucose, MDH, aldolase, and inorganic phosphate were determined in arterial and coronary vein blood. The oxidation-reduction potential (redox potential) differences between arterial and coronary vein blood were calculated from the ratio of lactate/pyruvate to determine the presence of myocardial anoxia. In PMD the cardiac output was elevated, and there was a rise in... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Mich. (CI) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1962Volume 56, Issue 4Page: 672-672KeywordsBloodCardiovascular therapyGlucoseHeartHeart failureLactatesMuscular dystrophiesPhosphatesPyruvateVeins Issue Published: 1 April 1962 PDF DownloadLoading ...
AI-10 * DISTINCT EGFR SIGNALING IN GLIOBLASTOMA: WILD-TYPE EGFR PROMOTES INVASION WHILE EGFRvIII DRIVES PROTOTYPICAL SFK c-SRC ACTIVATION TO FOSTER ANGIOGENESIS
Authors: E. Eskilsson, G. Rosland, K. Talasila, R. Jahedi, L. Leiss, H. Saed, O. Keunen, S. Foerster, P. Euskirchen, J. Hossain, T. Taxt, R. Jirik, M. Lund-Johansen, P. O. Enger, C. Ritter, S. Niclou, R. Bjerkvig, H. Miletic
Journal: Neuro-Oncology (2014)

EGFR gene amplification is observed in upwards of 40% of glioblastoma (GBM) biopsies, and genetic aberration to EGFR at large has been described to occur in excess of 50%. Our lab has developed a clinically relevant in vivo xenograft model derived from patient biopsies in which we are able to accurately study EGFR signaling in human GBM. We previously reported that wild-type EGFR amplification and activation promotes invasion and development of GBM independent of angiogenesis. Importantly, detected in half of GBMs harboring EGFR amplification, the most prominent EGFR mutation arises upon deletion of exons 2 through 7 to generate the constitutively active truncation mutant EGFRvIII. Here we report that while wild-type EGFR overexpression sustains invasion, EGFRvIII, in contrast, induces more aggressive and angiogenic tumor growth. We further performed signaling complex immunocapture mass spectrometry which revealed that EGFRvIII-mediated signaling is divergent from that of its wild-type counterpart. In particular the non-receptor tyrosine kinase c-SRC was highly upregulated and activated in EGFRvIII tumors as verified on western blots and by immunohistochemistry. Inhibition of c-SRC activity by shRNA and Src inhibitors decreased VEGF levels in EGFRvIII tumor cells. Furthermore, EGFRvIII+ xenograft tumors expressing c-SRC shRNA became less angiogenic and aggressive - indeed similar to control tumors lacking EGFRvIII. When overexpressing constitutively activated Src in control tumor cells, we could recapitulate the oncogenic phenotype of EGFRvIII as the tumor cells secreted higher levels of VEGF and became more aggressive and angiogenic in vivo. We hereby report evidence that the EGFRvIII-driven oncogenic activity and angiogenic tumor growth is mediated by c-SRC. In conclusion, our results suggest that the EGFRvIII-SRC-VEGF axis represents an important mechanism of tumor angiogenesis in GBM.
Methionine synthase A 2756 G/ methylenetetrahydrofolate reductase C 677 T combined polymorphisms: Either protective or risk factors of coronary artery disease
Authors: Jean-Louis P. Guéant, Rosa M. Guéant-Rodriguez, Charles E. Adjalla, Idrissia Abdelmouttaleb, Yves Juillière, Nicolas Danchin
Journal: Journal of the American College of Cardiology (2003)
Antibiotics or Placebo for Chronic Obstructive Pulmonary Disease
Authors: JOSEPH J. DUDEK
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 July 1987Antibiotics or Placebo for Chronic Obstructive Pulmonary DiseaseJOSEPH J. DUDEK, M.D., ROBERT M. HEANEY, M.D.JOSEPH J. DUDEK, M.D.Search for more papers by this author, ROBERT M. HEANEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-1-117 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the february issue, anthonisen and colleagues (1) described a randomized, double-blinded, crossover trial of antibiotics or placebo in the treatment of exacerbations of chronic obstructive pulmonary disease. We congratulate them on a well-designed and conducted study that addresses a common clinical problem. Although well reported, however, their article raised several specific questions.The authors discussed their criteria for the onset and resolution of exacerbations. We agree with their choice of patient symptoms and are encouraged by their kappa scores, which are consistently above 0.51 for the 3 key symptoms (increased dyspnea, increased sputum production, change in...References1. ANTHONISENMANFREDAWARRENHERSHFIELDHARDINGNELSON NJCEGN. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med. 1987; 106:196-204. LinkGoogle Scholar2. STUBBINGMATHEWROBERTSCAMPBELL DRRE. Some physical signs in patients with chronic airflow obstruction. Am Rev Respir Dis. 1982;125:549. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Louis University Medical Center St. Louis, MO 63110 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1987Volume 107, Issue 1Page: 117-118KeywordsAntibioticsChronic obstructive pulmonary diseaseDyspneaSputum Issue Published: 1 July 1987 PDF DownloadLoading ...
Anal Sphincter Defects in Fecal Incontinence: Correlation between Endosonography and Surgery
Authors: C. Meyenberger, P. Bertschinger, G. F. Zala, P. Buchmann
Journal: Endoscopy (1996)

Endoscopic ultrasound provides accurate information about the anatomy of the anal sphincter. The purposes of this study were to evaluate the use of flexible echo endoscopes to examine the anal sphincters, to validate the diagnosis of internal and external sphincter defects obtained using echo endoscopes by comparison with surgical findings, and to assess the outcome after surgical sphincter repair.Twenty-eight patients (13 women, 15 men, median age 50 years, range 30-83) with fecal incontinence--which was of traumatic origin in all but one (childbirth: n = 8; anorectal surgery: n = 17; biopsy of the prostate: n = 2; no trauma: n =1)--were prospectively investigated by endosonography using an echo colonoscope (n = 14) or an echo gastroscope (n = 14) (CF-UM20, GF-UM20, Olympus Optical). The location and extent of the defects of the internal or external sphincters, or both, were compared with the surgical findings in all patients. The surgical outcome was defined as excellent, improved, or unchanged.At surgery, 25 of the 28 patients had an isolated internal sphincter defect (n = 15) or combined sphincter defect (n = 10). Endoscopic ultrasound identified all of the external anal sphincter defects (n = 10), and correctly excluded a defect in 15 of 18 patients (sensitivity, specificity, and accuracy 100%, 83% and 89%, respectively). All of the internal sphincter defects (n = 25) were detected by endosonography. In three patients, a postulated intact internal sphincter was confirmed by surgery (accuracy 100%). In two patients, the extent of the sphincter defect was underestimated. Despite good visualization of the internal and external anal sphincters, as well as of the puborectal muscle in all patients, the shape, diameter, and full radial image sector (360 degrees) of the echo gastroscope made this instrument more practicable than the echo colonoscope. Nineteen of 25 patients who underwent surgery (76%) with proved sphincter defects experienced improvement, the figure reaching 87% (13 of 15) in patients who received isolated internal sphincter defect repair.Anal endosonography, even using flexible echo endoscopes, is an accurate method for identifying anal sphincter defects, and is the method of choice for preoperative sphincter mapping with special regard to internal sphincter repair, which can be carried out with excellent results.
P1299 PEARL-III: 12 WEEKS OF ABT-450/R/267 + ABT-333 ACHIEVED SVR IN &gt;99% OF 419 TREATMENT-NAIVE HCV GENOTYPE 1B-INFECTED ADULTS WITH OR WITHOUT RIBAVIRIN
Authors: P. Ferenci, A. Nyberg, P. Enayati, D. Bernstein, Y. Baruch, F.A. Caruntu, V. Chulanov, E. Janczewska, Z. Younes, R.T. Marinho, G. Rizzardini, J. Gervain, R. Planas, C. Moreno, W. Xie, D. Cohen, M. King, T. Podsadecki, K.R. Reddy
Journal: Journal of Hepatology (2014)
Sarcolemmal ATP-Sensitive K+ Channels Control Energy Expenditure Determining Body Weight
Authors: Alexey E. Alekseev, Santiago Reyes, Satsuki Yamada, Denice M. Hodgson-Zingman, Srinivasan Sattiraju, Zhiyong Zhu, Ana Sierra, Marina Gerbin, William A. Coetzee, David J. Goldhamer, Andre Terzic, Leonid V. Zingman
Journal: Cell Metabolism (2010)
Symptoms of oestrogen deficiency in women with oestradiol implants.
Authors: J. Studd, A. Henderson, T. Garnett, N. Watson, M. Savvas
Journal: BMJ (1989)

Triage labels: choosing the national standard SIR, -Drs K Mackway-Jones and B Ryan are quite correct in stating that the design of a national triage label presents a window of opportunity to improve disaster management a's a whole.'Those who have
Fluorine-18 fluorodeoxyglucose positron emission tomography in the preoperative staging of thoracic oesophageal and gastro-oesophageal junction cancer: A prospective study
Authors: I.E. Katsoulis, W.L. Wong, A.K. Mattheou, N. Damani, J. Chambers, J.I. Livingstone
Journal: International Journal of Surgery (2007)
Congenital Deficiency of a Factor in Normal Plasma That Reverses Microangiopathic Hemolysis and Thrombocytopenia
Authors: Jefferson D. Upshaw
Journal: New England Journal of Medicine (1978)

THE patient described below has been under observation for 11 years. Evidence to be presented suggests that she has the congenital deficiency of a factor in normal plasma that appears under some circumstances to be important in platelet and red-cell survival.Case ReportThe patient, now 29 years old, was noted at birth to have a rudimentary right radius and ulna, and a lobster-claw deformity of the right hand.From the age of six months to 12 years she had six to 10 episodes yearly characterized by the acute onset of high fever, generalized petechial rash, usually a clinically determinable . . .
“Pure Erythrocytosis”: Will Purism Prevail?
Authors: Harriet S. Gilbert
Journal: New England Journal of Medicine (1977)

Advances in medical knowledge tend to come in bursts or at least in great strides. A tiny nucleus of an idea gathers momentum and mass, like tumbleweed rolling through the desert. The sum total of what is gathered may be impure and imprecise, but subsequent honing pares away the excesses engendered by enthusiasm, leaving a useful concept with which we may operate and that we hold to be "truth." Formulation of the concept of myeloproliferative disease constituted such a sweeping advance, gathering up a multitude of clinical "entities" into a syndrome whose unifying lesion is localized at the level of . . .
Difficulties in diagnosing meningococcal meningitis.
Authors: T H Hughes-Davies
Journal: BMJ (1979)

incidence of allergic complications than those with no detected antigen in blood.3Furthermore, high concentrations of antigen in CSF at diagnosis with slow disappearance of antigen were associated with neurological damage.Thus, while I agree with the authors' two conclusions, which, I respectfully submit, are self-evident, there are well-known immuno- logical techniques which can improve diagnostic accuracy and which also have some prognostic and epidemiological value.
Nuffield council calls for ethical framework for developing world research
Authors: Eaton Lynn
Journal: BMJ (2005)

A sound ethical framework for research in developing countries is crucial for ensuring that participants are safe from exploitation, says a report from the Nuffield Council on Bioethics.But some of the measures introduced to try to offer such protection-such as arguing that participants should have access to the same standards of care made available in developed countries-are impractical and can undermine potential research opportunities, it says.The conclusions follow a discussion paper issued by the council in 2002 and a subsequent meeting in Cape Town, South Africa, in February 2004, attended by 58 participants from 28 countries, including India, China, Kenya, and Botswana.The discussion paper published by the council looks at the current laws governing research in developing countries, including the 1964 Declaration of Helsinki, which has since been amended five times by the World Medical Association and clarified by the Council for International Organizations of Medical Sciences.Research in developing countries is crucial, the paper says, for improving health care.But researchers in these countries often cannot conduct their own research, making partnership with more developed countries essential.
Unusual Ventilation-Perfusion Scans in the Follow-Up of Two Lung Transplant Patients
Authors: Mariana Andrade, Bruno Krug, Cécile Abraham, Anne-Sophie Pirson, Luc Delaunois, Thierry Vander Borght
Journal: Clinical Nuclear Medicine (2008)

Airway anastomotic stenosis after lung transplantation is a potential cause of early morbidity and mortality, especially after double lung transplantation. A 55-year-old woman and a 63-year-old man were referred for ventilation-perfusion scans [Kr-81 and Tc-99m macroaggregated albumin (MAA)] for routine assessment 3 months after having benefited from a bilateral lung transplantation The unilateral absence of ventilation in each case suggested main bronchial obstruction. In the former patient, the bronchoscopy was inconsistent with the lung scan findings, showing only an incomplete stenosis secondary to an aspergillosis fibrin lesion. A worsening of the obstruction in the supine position was thus suspected and confirmed by improved ventilation in the upright position. In the latter case, the before and after ventilation-perfusion scans showed the benefits of dilatation treatment of the stenotic bronchial anastomosis. These cases illustrate the benefit of ventilation-perfusion scans in the detection of airway anastomotic stenosis after lung transplantation, even in non-, or poorly symptomatic patients, and their usefulness in the evaluation of the response to treatment.
Detection of Allergy to Penicillin and Other Antigens by In-vitro Passive Sensitization and Histamine Release from Human and Monkey Lung
Authors: E. S. K. Assem, H. O. Schild
Journal: BMJ (1968)

Preparations of chopped human and monkey lung were used to estimate the reaginic activity of serum from allergic patients. The lung preparation was passively sensitized by incubation with serum taken from the patients, and then challenged with the antigen responsible for the allergy. Measurement of the histamine released from the lung gave a quantitative assessment of the level of reaginic activity in the patient9s serum. Tests were done on patients allergic to four natural antigens, including grass pollen, and to penicillin. Human lung proved more sensitive and possibly more specific than monkey lung in testing for natural allergies. The results of testing for penicillin allergies were less satisfactory, possibly because of the difficulty of reconstructing the appropriate antigen.
Epidemiology of Coccidioidomycosis
Authors: William Drips, Charles E. Smith
Journal: JAMA (1964)

COCCIDIOIDOMYCOSIS in the United States occurs with significant incidence only in certain endemic areas in the southwestern states. Most longtime residents of these endemic areas, usually having acquired their infections in mild or inapparent form, possess a high level of immunity.<sup>1-3</sup>However, newly arriving populations, best exemplified by military personnel and migrant agricultural workers, previously have been shown to be highly susceptible to coccidioidal infection.<sup>2,4</sup>Epidemiologic surveys conducted by Smith et al at four World War II San Joaquin Valley military airfields during 1941-1945 showed that high infection rates could be reduced markedly by vigorous measures to minimize dust exposure.<sup>4,5</sup>Although the mortality rate for coccidioidomycosis is very low, the morbidity associated with clinically apparent disease still is of considerable importance at modern day military bases. Coccidioidal respiratory illness at Williams Air Force Base<sup>6</sup>and Luke Air Force-Base<sup>7</sup>in Arizona and at Naval Air Station,
Reduced expression of epidermal growth factor receptor related protein in gastric cancer
Authors: W S Moon, A S Tarnawski, J Chai, J T Yang, A P N Majumdar
Journal: Gut (2005)

<b>Objectives:</b> The recently cloned epidermal growth factor receptor related protein (ERRP) has been proposed to be a negative regulator of the epidermal growth factor receptor (EGFR). Because of the causal involvement of EGFR and its ligands in gastric cancer growth, we investigated expression of ERRP and cell proliferation in human gastric cancer. <b>Methods:</b> We examined ERRP expression and localisation in surgical specimens of gastric cancers from 47 patients versus non-malignant gastric mucosa and determined their relationship to cell proliferation and differentiation. We also examined expression of ERRP by western blotting in three different gastric cancer cell lines. To further determine the functional properties of ERRP, we examined the effect of ERRP on epidermal growth factor (EGF) induced EGFR phosphorylation essential for its activation in MKN-28 gastric cancer cells. <b>Results:</b> ERRP expression was dramatically reduced in gastric cancers (34% of all specimens positive) compared with non-malignant gastric mucosa (66% of specimens positive). Expression of ERRP in cancer cells inversely correlated with cell proliferation and grade of malignancy. Cell lines derived from metastatic gastric cancers had reduced ERRP expression compared with cell lines derived from a non-metastatic cancer. Exogenous ERRP protein markedly inhibited EGF induced EGFR phosphorylation in gastric cancer cells providing a novel molecular mechanism of its action. <b>Conclusions:</b> Our data indicate that downregulation of ERRP could play an important role in gastric cancer differentiation and progression. ERRP is a negative regulator of tumour cell proliferation and may exert its inhibitory effect, in part, by attenuating EGFR activation.
HOX11L2/TLX3 is transcriptionally activated through T-cell regulatory elements downstream of BCL11B as a result of the t(5;14)(q35;q32)
Authors: X.-Y. Su, V. Della-Valle, I. Andre-Schmutz, C. Lemercier, I. Radford-Weiss, P. Ballerini, M. Lessard, M. Lafage-Pochitaloff, F. Mugneret, R. Berger, S. P. Romana, O. A. Bernard, V. Penard-Lacronique
Journal: Blood (2006)
Undertreatment of Mental Health Problems in Adults With Diagnosed Diabetes and Serious Psychological Distress
Authors: Chaoyang Li, Earl S. Ford, Guixiang Zhao, Lina S. Balluz, Joyce T. Berry, Ali H. Mokdad
Journal: Diabetes Care (2010)

OBJECTIVE To assess the prevalence and correlates of undertreatment for mental health problems among adults with diabetes and serious psychological distress (SPD). RESEARCH DESIGN AND METHODS We analyzed data of adults aged ≥18 years from the 2007 Behavioral Risk Factor Surveillance System. SPD was assessed with the Kessler-6 scale. RESULTS The prevalence of untreated SPD was estimated to be 2.1 ± 0.1% (mean ± SE), 3.4 ± 0.3%, and 2.0 ± 0.1% in the total population, diabetic population, and nondiabetic population, respectively. Among people with SPD, those with diagnosed diabetes had a lower rate of undertreatment for mental health problems (45.0%) than those without diabetes (54.9%) (P = 0.002). Nonwhite race/ethnicity, advanced age, lack of health insurance, and currently being employed were associated with increased likelihood of undertreatment for mental health problems (P &amp;lt; 0.05). CONCLUSIONS People with diagnosed diabetes may be screened for SPD and treated for specific mental health problems in routine health care.
648. Lentiviral Vector Expressing Retinoic Acid Receptor â2 Promotes Regeneration in a Rat Spinal Cord Injury Model
Authors: Liang-Fong Wong, Ping K. Yip, Anna Aurora Battaglia, John Grist, Martin Howard Jones, Malcolm Maden, S M Kingsman, A J Kingsman, Stephen Brendan McMahon, N.D. Mazarakis
Journal: Molecular Therapy (2005)

Top of pageAbstract
After spinal cord injury, axons in the central nervous system (CNS) fail to regenerate resulting in paralysis. The factors that contribute to this regenerative failure include the inihibitory environment at the injury site as well as the intrinsic growth potential of injured axons. Previously we have demonstrated that retinoic acid receptor |[beta]|2 (RAR|[beta]|2), a transcription factor activated by retinoic acid, can induce neurite outgrowth in adult spinal cord explants and promote functional regeneration in a rat model of cervical rhizotomy. Here we investigate the utility of a minimal equine infectious anaemia virus (EIAV)-based lentiviral vector expressing RAR|[beta]|2 in stimulating axonal outgrowth in a rat spinal cord injury model. EIAV-RAR|[beta]|2 was injected into the sensorimotor cortex prior to lesioning of dorsal columns in the cervical cord. At 4 weeks after lesion, RAR|[beta]|2-treated animals demonstrated regeneration of descending corticospinal axons up to, and beyond the lesion site, compared to control animals that received an EIAV vector expressing |[beta]|-galactosidase. These anatomical observations correlated to an improvement in task performance in locomotor and proprioceptive behavioural tests as well as an increase in post-synaptic activity below the lesion after electrical stimulation of corticospinal neurons. This suggests that lentiviral-mediated delivery of RAR|[beta]|2 promoted functional regeneration of CNS axons in the injured spinal cord and may thus be exploited as a novel approach to therapeutic applications in the treatment of spinal cord injuries.
Uncertainties in baseline risk estimates and confidence in treatment effects
Authors: F. A. Spencer, A. Iorio, J. You, M. H. Murad, H. J. Schunemann, P. O. Vandvik, M. A. Crowther, K. Pottie, E. S. Lang, J. J. Meerpohl, Y. Falck-Ytter, P. Alonso-Coello, G. H. Guyatt
Journal: BMJ (2012)

The GRADE system provides a framework for evaluating how risk of bias, publication bias, imprecision, inconsistency, and indirectness may reduce confidence in estimates of relative effects of interventions on outcomes. However, GRADE and all other systems for rating confidence in effect estimates do not fully address uncertainty in baseline risk and its impact on confidence in absolute estimates of treatment effect. In this article the authors examine factors that may reduce confidence in estimates of baseline risk and thus estimates of absolute treatment benefit