Classification of Polycythemic Disorders
Authors: JOHN F. MURRAY
Journal: Annals of Internal Medicine (1966)

Review1 April 1966Classification of Polycythemic DisordersWith Comments on the Diagnostic Value of Arterial Blood Oxygen AnalysisJOHN F. MURRAY, M.D.JOHN F. MURRAY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-4-892 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptStudies on the mechanisms that control erythropoiesis have revealed that inadequate oxygenation is a potent stimulus that increases erythrocyte production. Although recent investigations indicate that other factors are also important (1), the common denominator for a variety of experimental and clinical conditions that affect red cell formation is the relationship between the metabolic needs of an organism and the oxygen available to meet these requirements; these observations have led to the oxygen supply and demand theory for the regulation of erythropoiesis (2). 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CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN F. MURRAY, M.D.Affiliations: Los Angeles, CaliforniaFrom the Departments of Medicine and Physiology, University of California Medical Center, Los Angeles, Calif.This study was supported in part by grant H-08807-01 from the U. S. Public Health Service, Washington, D. C.Requests for reprints should be addressed to John F. Murray, M.D., Department of Medicine, University of California Medical Center, Los Angeles, Calif. 90024. 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