tbuckley/cabot-search huggingface dataset:
Intraoral and respiratory allergy to Eruca sativa (Cruciferae family) in a subject with sensitization to pollen allergens
Authors: Gennaro Liccardi, Antonello Salzillo, Gianni Mistrello, Daniela Roncarolo, Maria D'Amato, Gennaro D'Amato
Journal: Journal of Allergy and Clinical Immunology (1998)
Role of proaggregatory and antiaggregatory prostaglandins in hemostasis. Studies with combined thromboxane synthase inhibition and thromboxane receptor antagonism.
Authors: P Gresele, J Arnout, H Deckmyn, E Huybrechts, G Pieters, J Vermylen
Journal: Journal of Clinical Investigation (1987)

Thromboxane synthase inhibition can lead to two opposing effects: accumulation of proaggregatory cyclic endoperoxides and increased formation of antiaggregatory PGI2 and PGD2. The elimination of the effects of the cyclic endoperoxides by an endoperoxide-thromboxane A2 receptor antagonist should enhance the inhibition of hemostasis by thromboxane synthase blockers. We have carried out a series of double-blind, placebo-controlled, crossover studies in healthy volunteers to check if this hypothesis may be operative in vivo in man. In a first study, in 10 healthy male volunteers, the combined administration of the thromboxane receptor antagonist BM 13.177 and the thromboxane synthase inhibitor dazoxiben gave stronger inhibition of platelet aggregation and prolonged the bleeding time more than either drug alone. In a second study, in 10 different healthy male volunteers, complete inhibition of cyclooxygenase with indomethacin reduced the prolongation of the bleeding time by the combination BM 13.177 plus dazoxiben. In a third study, in five volunteers, selective cumulative inhibition of platelet TXA2 synthesis by low-dose aspirin inhibited platelet aggregation and prolonged the bleeding time less than the combination BM 13.177 plus dazoxiben. In vitro, in human platelet-rich plasma stimulated with arachidonic acid, the combination of BM 13.177 and dazoxiben increased intraplatelet cAMP while the single drugs did not affect it. Our results indicate that prostaglandin endoperoxides can partly substitute for the activity of TXA2 in vivo in man and that an increased formation of endogenous antiaggregatory and vasodilatory prostaglandins, as obtained with selective thromboxane synthase inhibitors, may contribute to the impairment of hemostasis.
NF-κB-dependent increase in intrarenal angiotensin II induced by proteinuria
Authors: Osamu Takase, Takeshi Marumo, Naohiko Imai, Junichi Hirahashi, Atsushi Takayanagi, Keiichi Hishikawa, Matsuhiko Hayashi, Nobuyoshi Shimizu, Toshiro Fujita, Takao Saruta
Journal: Kidney International (2005)
The mitral valve orifice method for noninvasive two-dimensional echo Doppler determinations of cardiac output.
Authors: D C Fisher, D J Sahn, M J Friedman, D Larson, L M Valdes-Cruz, S Horowitz, S J Goldberg, H D Allen
Journal: Circulation (1983)

We developed and validated a mitral valve orifice method for Doppler cardiac output determination. In 15 open-chest dogs, cardiac output was controlled and measured by a roller pump interposed between the right atrium and pulmonary artery as a right-heart bypass. Left heart flows were measured in the open-chest dog model by Doppler measurements at the mitral valve orifice and compared not only to volume flow measured by the roller pump, but to electromagnetic flow meters as well. The maximum mitral valve orifice area was measured off short-axis two-dimensional echocardiographic views by planimetry. The maximal orifice was then adjusted for its diastolic variation in size by calculating a ratio of mean-to-maximal mitral valve separation on a derived M-mode echocardiogram. Flow was sampled parallel to mitral valve inflow in a four-chamber plane. The multiplication of mean flow throughout the cardiac cycle by the mean mitral valve area after correction for diastolic size variation yielded a cardiac output determination that could be compared to the roller pump measurement. Fifty-two cardiac output determinations over roller pump values of 1-5 l/min yielded a high correlation between roller pump flows and Doppler (r = 0.97 +/- 0.23 l/min). Our study shows that the mitral valve orifice provides an accurate site for Doppler cardiac output measurements.
A comparison of the WHO 2004 and 2010 classification systems in pancreatic neuroendocrine tumors (PNET).
Authors: Ashwin Reddy Sama, Aakanksha Asija, James Casey, Jocelyn Andrel-Sendecki, Nancy Lewis, Harish Lavu, Jordan Michael Winter, Jonathan Robert Brody, Edith P. Mitchell, Charles Yeo, Anthony Prestipino, Madhavan V. Pillai
Journal: Journal of Clinical Oncology (2015)

267 Background: PNETs are rare tumors with multiple classification systems. We compared the WHO 2004 and 2010 classification systems for predicting mortality and metastasis. Variables associated with mortality were explored. Methods: Descriptive statistics were calculated for characteristics of 50 PNET patients. The relationship between the WHO 2004 and 2010 system was investigated using an exact Chi squared test. WHO grade categorization was explored by vital status, by the exact method, in order to determine if there was a difference in survivorship and metastasis by grading system. Associations between death and categorical variables were tested using exact methods and between death and continuous variables by the Wilcoxon test. Survival was explored using Cox Proportional Hazards regression (COX). Results: 62 % of patients were female and the median age was 60 years. Both grading systems were strongly associated with predicting mortality (table 1); all cases of mortality were in the higher grades. The 2010 grades do slightly better in predicting metastasis as metastases occur only in high grades (G2 and G3). Patients with lymphovascular or perineural invasion had significantly higher mortality. Mitotic Index was significantly different with a median of 0 in live patients versus 15 in deceased, p &lt;0.001. This was similarly borne out in the survival analysis using COX, where for every one unit increase in Mitotic Index, there was about a one third increase in the hazard of death (p = 0.001). There was no significant difference in survival by tumor size, comorbidities, or margins. Conclusions: The WHO 2010 grading system is strongly associated with predicting mortality and performs better in predicting metastasis than the 2004 grading system. [Table: see text]
Infections on return from abroad-II.
Authors: E Walker, G Williams
Journal: BMJ (1983)

ABROAD-I I JaundiceThe two commonest infective causes of jaundice in the returning traveller are viral hepatitis and malaria.Haemolysis due to falciparum malaria must be excluded first because of the need for urgent treatment.Both hepatitis A and B are normally afebrile illnesses once jaundice has appeared and can therefore be distinguished clinically from malaria.The severity of an acute hepatitis A or B infection is related to age, with children usually getting milder illnesses.Despite the high carriage rates of i~-1~X >g<0; <; : :$.hepatitis B surface antigen in some tropical countries, hepatitis B usually affects only those travellers who abuse intravenous drugs, make casual EC .t..:W.:Nt+K | sexual contacts, get tattooed, or are occupationally exposed to blood.The 4 ta 0>0 'A g u | diagnosis of hepatitis is confirmed by raised liver enzyme levels, and the infecting agent is determined by the presence of hepatitis A IgM antibodies or hepatitis B surface antigen.Occasionally a non-B hepatitis occurs in a carrier of hepatitis B surface antigen, and other investigations will be | < 5.: .-"£ 's B.g1
A National Action Plan to Meet Health Care Quality Information Needs in the Age of Managed Care
Authors: Dale V. Shaller
Journal: JAMA (1998)

Concerted national action is needed to meet the growing demand for health care quality information among all health care stakeholders. We propose a coordinated national network of independent, public-private quality measurement alliances established through strong purchaser and consumer leadership at the state, regional, or local levels. These independent alliances could assume a variety of organizational forms, but all would undertake specific quality measurement and consumer information projects to meet local health care market needs by drawing on various combinations of the emerging national standardized quality measures. Local implementation of quality measures based on national standards will facilitate cross-market benchmarking and multistate comparisons useful not only to state and local market constituencies, but to national employers, health plans, provider organizations, and the federal government as well. Successful models of such alliances already exist that demonstrate the feasibility of this national strategy, but concerted national leadership and federal matching funding will be needed to meet the scope of implementation required in markets across the country.
Ventricular tachycardia due to cardiac ischaemia: assessment by exercise electrocardiography
Authors: S. Talbot, D. Kilpatrick, D. Krikler, C. M Oakley
Journal: BMJ (1978)

Although ventricular tachycardia is a well-known complication of myocardial ischaemia and may be provoked by exercise, many patients may appreciate only the angina and be unaware of the unduly rapid heart rate that precipitates it. Exercise testing is needed to show this arrhythmia and to enable treatment to be started. Twenty-three patients were found to have chronic ischaemic heart disease complicated by ventricular tachycardia. Six patients with old myocardial infarction had ventricular tachycardia at rest which required conversion to sinus rhythm; 17 patients developed ventricular tachycardia only when they exercised. In 12 of these 17 patients coronary angiography showed disease of the anterior descending branch of the left coronary artery; other vessels were usually also affected. Although beta-adrenergic blocking drugs increased exercise tolerance, ventricular tachycardia still occurred when the heart rate on exercise reached a level similar to that before treatment. In five patients coronary artery bypass surgery was performed because of angina and exercise-induced ventricular tachycardia. Exercise tolerance was increased in all three patients who underwent exercise tests after operation, and in two of these patients, both of whom were known to have patent grafts, ventricular tachycardia was abolished. If part of the beneficial effect of coronary bypass surgery is preventing life-threatening ventricular arrhythmias it is essential to detect these, and ambulatory monitoring and stress testing have a complementary role.
Unhealthy foods feature prominently on children's TV, study shows
Authors: J. Wise
Journal: BMJ (2014)

Unhealthy foods and sugary drinks are commonly shown on children’s television programmes in the United Kingdom and Ireland, often portrayed in a positive light, new research shows.1

The researchers assessed the frequency and type of food and drink portrayals in children’s television programmes between 6 am and 5 pm Monday to Friday on the BBC and RTE channels in 2010. Both channels are national broadcast …
A Technical Complication of Radiosynovectomy in the Ankle
Authors: Gokhan Koca, Bulent Alioglu, Hakan Ozsoy, Meliha Korkmaz, Hasan Ikbal Atilgan
Journal: Clinical Nuclear Medicine (2013)

Chronic hemophilic synovitis due to intra-articular bleeding in hemophilia A (a congenital coagulation defect) is a common manifestation. Radiosynovectomy is used for the ablation of chronic hemophilic synovitis. Complications due to radiosynovectomy may be seen, such as leakage of radioactivity to the lymph nodes, liver, and spleen via the lymphatic system. We report herein 2 cases that developed leakage to the distal tibiofibular syndesmosis, lymph nodes, liver, and spleen after radiosynovectomy to the ankles. In order to prevent leakage, low-volume injection is recommended.
CMV INFECTION IN THE ERA OF TACROLIMUS/MYCOPHENOLATE: IS THERE STILL AN IMPACT TO DEVELOP CARDIAC ALLOGRAFT VASCULOPATHY?
Authors: David Perkel, Jignesh Patel, Michelle Kittleson, David Chang, Lawrence Czer, Fardad Esmailian, Jon Kobashigawa
Journal: Journal of the American College of Cardiology (2012)
Radiology in the Doldrums
Authors: P. F. Harris
Journal: BMJ (1968)

<h3>Abstract</h3> Prematurity can result in widespread neurodevelopmental impairment, with the impact of premature extrauterine exposure on brain function detectable in infancy. A range of neurodynamic and haemodynamic functional brain measures have previously been employed to study the neurodevelopmental impact of prematurity, with methodological and analytical heterogeneity across studies obscuring how multiple sensory systems are affected. Here, we outline a standardised template analysis approach to measure the evoked response magnitudes for visual, tactile, and noxious stimulation within individual infants (n=15) using EEG. By studying a cohort of very preterm infants longitudinally (n=10), we observe that the evoked response template magnitudes are significantly associated with age-related maturation. In a subsequent cross-sectional study, we observe significant differences in visual and tactile response template magnitudes between infants born in the very preterm and late preterm periods (n=10 and 8), age-matched at study. These findings demonstrate the significant impact of premature extrauterine exposure on brain function and suggest that prematurity can accelerate maturation of the visual and tactile sensory system in infants born very prematurely. This study highlights the value of using a standardised multi-modal evoked-activity analysis approach to assess premature neurodevelopment, and will likely complement resting-state EEG and behavioural assessments in the study of the functional impact of developmental care interventions. <h3>Highlights</h3> Multi-modal sensory stimulation is used to assess premature infant brain function A template analysis approach is outlined for multi-modal stimulus-evoked EEG activity Stimulus-evoked template magnitudes change with age Prematurity results in accelerated maturation of visual and tactile sensory systems
Paediatric respiratory training in Europe: syllabus and centres: Fig. 1.—
Authors: M.S. Zach
Journal: European Respiratory Journal (2002)

⇓Paediatric respiratory medicine (PRM) is established as a board-certified paediatric subspeciality in several parts of the world. Training programmes have existed in Australia since the seventies and in the USA since 1986 1, 2. In contrast, PRM has grown inhomogeneously in Europe; a survey in 1990 showed large differences in the professional and scientific situation between nations, but also between different areas, hospitals, and medical schools in the same country 3.



Fig. 1.— 

From the institution of the European Respiratory Society (ERS) in 1990, its Paediatric Assembly has been a scientific and professional platform for European PRM. The Long Range Planning Committee of this assembly, founded from 1992, is concerned with long-term assembly projects including a standardisation of PRM training in Europe. As several European countries have started to establish national training programmes in PRM, standardisation at a European level, if done timely and competently, has the potential to harmonise these different national training concepts.

In 1994, the ERS Paediatric Assembly established first contacts with the Union of European Medical Specialists (UEMS) sections on Paediatrics and Pneumology. Subsequently, the ERS president (at this time a paediatrician) was invited to the 1995 meeting of the paediatric UEMS section (Confederation of European Specialists in Paediatrics (CESP)). CESP had then already set up a European Board of Paediatrics in order to standardise training in all aspects of Paediatrics at a European level. Negotiations were initially difficult but CESP finally agreed that it should develop a clearly defined position and programme for PRM as a model for tertiary care paediatrics. Subsequently, CESP has also invited other paediatric subspecialities to cooperate, and PRM can pride itself with having had a pioneering role in this development. The ERS Paediatric Assembly subsequently applied for a subsection status of PRM in the UEMS section on paediatrics. …
Can Patients with Obstructive Sleep Apnea Titrate Their Own Continuous Positive Airway Pressure?
Authors: Michael F. Fitzpatrick, Christi E. D. Alloway, Tracy M. Wakeford, Alistair W. MacLean, Peter W. Munt, Andrew G. Day
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

Manual continuous positive airway pressure (CPAP) titration in a sleep laboratory is costly and limits access for diagnostic studies. Many factors affect CPAP compliance, but education and support, rather than in-laboratory CPAP titration, appear to be pivotal. Self-adjustment of CPAP at home will provide equal or superior efficacy in the treatment of obstructive sleep apnea (OSA) as compared with in-laboratory titration. A randomized, single-blind, two-period crossover trial of CPAP treatment at the in-laboratory-determined optimal pressure versus at-home self-adjustment of CPAP (starting pressure based on prediction equation). Eighteen CPAP-naive patients (16 males, 50 +/- 15 years old, apnea hypopnea index 40 +/- 20) with a new diagnosis of OSA were tested. Testing was performed before and after CPAP treatment in each of two 5-week study limbs. CPAP, compliance with CPAP treatment, the Sleep Apnea Quality of Life Index, the Functional Outcomes of Sleep Questionnaire score, the Epworth sleepiness scale score, sleep architecture, sleep apnea severity, and maintenance of wakefulness tests were performed. Both modes of CPAP treatment significantly improved objective and subjective measures of OSA, but they did not differ in efficacy. Home self-titration of CPAP is as effective as in-laboratory manual titration in the management of patients with OSA.
NHS funding crisis provides opportunity to promote greater self care among patients
Authors: J. Carlowe
Journal: BMJ (2009)

The NHS is guilty of perpetuating a culture of dependency, health professionals decided this week at a conference on patients caring for themselves.

Some 85% of people who attended the event, run by the Royal College of General Practitioners and the Proprietary Association of Great Britain, subscribed to this view after learning that there are 57 million consultations for minor ailments in England every year.

They were told that conditions for the 12 most common minor ailments, including constipation, dermatitis, and back pain, account for 75% of all consultations and cost the English NHS £2bn (€2.3bn; $3.4bn) …
Editorial: Rodent rabies
Authors: C. F. Von Reyn
Journal: JAMA (1976)

The March 15 (vol 235) cover of<i>JAMA</i>refers to an article on rabies with a photograph of a red squirrel and a comment (p 1088) warning that the bite of a red squirrel "can leave one with rabies." In fact, there has never been a case of human rabies in this country attributed to the bite of a squirrel, nor any other rodent (chipmunk, mouse, rat, squirrel). Rabies is not endemic in rodents. A recent review summarizes the rodent rabies situation in the United States.<sup>1</sup>Although 25,000 rodents are examined for rabies annually by various laboratories, only four or five are found to have rabies. There is no evidence that these few confirmed-rabid rodents play any role in the spread of rabies in its major wildlife hosts, the carnivores. Finally, human rabies has never been traced to a rodent, despite the fact that at least 24,000 persons are
BLASTOMYCOSIS OF THE BLADDER
Authors: B. W. Rhamy
Journal: JAMA (1926)

One may find an occasional yeast cell in pus or in non-catheterized urine, but so far as I am able to ascertain there is no reported case of blastomycotic cystitis. This case occurred in a physician, aged about 47. In October, 1922, he had a cystitis, with<i>Streptococcus mucosus</i>, which lasted about a year, clearing up under autogenous vaccine and methenamine. During the night of May 5, 1925, he had a chill with rather marked malaise, weakness, a temperature of 101 F., and a moderate night sweat toward morning. During the next day, he had frequent urination with burning and tenesmus. This continued and, May 8, he submitted himself to me for examination, supposing the trouble to be a return of the former cystitis. Urine was passed in a sterile bottle after the meatus was washed with alcohol, and examined immediately, as the patient was from out of town
Differential effects of targeting Notch receptors in a mouse model of liver cancer
Authors: Erik G. Huntzicker, Kathy Hötzel, Lisa Choy, Li Che, Jed Ross, Gregoire Pau, Neeraj Sharma, Christian W. Siebel, Xin Chen, Dorothy M. French
Journal: Hepatology (2014)

Primary liver cancer encompasses both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). The Notch signaling pathway, known to be important for the proper development of liver architecture, is also a potential driver of primary liver cancer. However, with four known Notch receptors and several Notch ligands, it is not clear which Notch pathway members play the predominant role in liver cancer. To address this question, we utilized antibodies to specifically target Notch1, Notch2, Notch3, or jagged1 (Jag1) in a mouse model of primary liver cancer driven by v-akt murine thymoma viral oncogene homolog and neuroblastoma RAS viral oncogene homolog (NRas). We show that inhibition of Notch2 reduces tumor burden by eliminating highly malignant HCC- and CCA-like tumors. Inhibition of the Notch ligand, Jag1, had a similar effect, consistent with Jag1 acting in cooperation with Notch2. This effect was specific to Notch2, because Notch3 inhibition did not decrease tumor burden. Unexpectedly, Notch1 inhibition altered the relative proportion of tumor types, reducing HCC-like tumors but dramatically increasing CC-like tumors. Finally, we show that Notch2 and Jag1 are expressed in, and Notch2 signaling is activated in, a subset of human HCC samples.These findings underscore the distinct roles of different Notch receptors in the liver and suggest that inhibition of Notch2 signaling represents a novel therapeutic option in the treatment of liver cancer.
INCIDENCE AND CORRELATES TO DEVELOP IATROGENIC FEMORAL PSEUDOANEURYSM AFTER PCI
Authors: Salem Badr, Israel Barbash, Hironori Kitabata, Joshua Loh, Sa'ar Minha, Lakshmana Pendyala, Rebecca Torguson, William Suddath, Augusto Pichard, Ron Waksman, Nelson Bernardo
Journal: Journal of the American College of Cardiology (2013)
THE DEBT OF OTOLOGY TO HELMHOLTZ.
Authors: B. ALEX. RANDALL
Journal: JAMA (1902)

The influence of Helmholtz upon otology is almost incalculable, although signalized by no instrument like the ophthalmoscope with its epoch-making application and its huge clinical field. Reflectors of various kinds to illuminate the aural, nasal and pharyngeal cavities had been somewhat used before his day and received but moderate impulse directly through his ophthalmoscope, for it was really the perforated concave mirror of Hoffmann and Ruete which became the aurist's illuminator; but they did lead to marked gain in diagnosis and treatment through rivalry with the ophthalmic progress which he had inaugurated. His advance lay principally in his contribution to the underlying science of acoustics. This he found in almost the rudimentary and empyrical phase known to Pythagoras; and just as his disproof of spontaneous generation made a beginning of minute biological study, and his physical corollary of the conservation of energy became the basis of all modern material science,
Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine
Authors: Niels Hagenaars, Marta Mania, Pascal de Jong, Ivo Que, Rob Nieuwland, Bram Slütter, Harrie Glansbeek, Jacco Heldens, Han van den Bosch, Clemens Löwik
Journal: Journal of Controlled Release (2010)