tbuckley/cabot-search huggingface dataset:
Treatment of chronic plaque-stage psoriasis and psoriatic arthritis with mycophenolate mofetil
Authors: Marcella Grundmann-Kollmann, Georg Mooser, Peter Schraeder, Thomas Zollner, Peter Kaskel, Falk Ochsendorf, Wolf-Henning Boehncke, Martina Kerscher, Roland Kaufmann, Ralf Uwe Peter
Journal: Journal of the American Academy of Dermatology (2000)
Correlation of hematopoietic progenitor cell count determined by the SE‐9000™ automated hematology analyzer with CD34<sup>+</sup> cell count by flow cytometry in leukapheresis products
Authors: Keon Uk Park, Sang Hee Kim, Cheolwon Suh, Shin Kim, Sun Jong Lee, Jung Sun Park, Hwa Jung Cho, Kang Wook Kim, Keehyun Lee, Hyo Jung Kim, Jinny Park, Young Joo Min, Jeong Gyoon Kim, Taewon Kim, Je Hwan Lee, Sung Bae Kim, Sang We Kim, Kyoo Hyung Lee, Jung Shin Lee, Woo Kun Kim, Chan Jeong Park, Hyun Sook Chi
Journal: American Journal of Hematology (2001)

Abstract The yield of stem cell collection after mobilization is crucial for autologous peripheral blood stem cell (PBSC) transplantation. Quantitative determinations of CD34 + cells using flow cytometry or stem cell culture have been used, but these methods require much time, technical experience, and expensive reagents. The automated hematology analyzer (Sysmex SE‐9000™, TOA, Japan) equipped with the Immature Information (IMI) channel for immature myeloid cells can detect IMI + cells within 90 sec. Detection is made possible by the combination of a special reagent system and direct current/radiofrequency biosensors. We studied the relation of IMI + cells and variable cell counts with CD34 + cell yield in autologous stem cell harvest. In a series of 32 patients (median age, 44 years; M:F = 11:21), 184 leukaphereses were performed after mobilization regimens with chemotherapy and G‐CSF or G‐CSF alone. Full blood cell counts were enumerated on peripheral blood (PB) samples taken prior to each leukapheresis. Mononuclear cell (MNC) and IMI + cell counts by automated hematology analyzer and flow cytometry based CD34 + cell yield were measured on the harvested product. The relationship among PB white blood cells (WBC), PB monocytes, IMI + cells, MNC, and CD34 + cell yield in a single leukapheresis was estimated by Pearson correlation analysis. PB WBC count showed no correlation with CD34 + cell yield in a single leukapheresis ( r = 0.02, P = 0.81). PB monocyte count showed a weak correlation ( r = 0.21, P = 0.01) and MNC in harvest also showed a weak correlation ( r = 0.36, P = 0.0001) with CD34 + cell yield. In contrast, CD34 + cell yield correlated well with IMI + cell count ( r = 0.68, P = 0.0001), and data could be fitted by a linear regression equation, y = 0.330 + 0.974 x. IMI + cell assay by the automated hematology analyzer correlated well with the CD34 + cell yield in a mobilized autologous stem cell harvest. The IMI + cell count might be used as a simple and efficient indicator of blood stem cell mobilization and collection. Am. J. Hematol. 67:42–47, 2001. © 2001 Wiley‐Liss, Inc.
Health Services in Cuba
Authors: Vicente Navarro
Journal: New England Journal of Medicine (1972)

Abstract The development of the Cuban health services during the last decade reflects a commitment to minimize the striking inequalities in the availability and consumption of health resources that previously existed between social classes, between cities and rural areas, and between regions. This process of equalization has been characterized by a centralization of inpatient services, a decentralization of ambulatory services, and an increase in the use and production of paramedical and auxiliary personnel within the health-services system. The health services today are structured according to regional models aimed at providing integrated care to the whole population, with integration of preventive with curative services, social with medical services, and environmental with personal health services. The universal coverage of the population has been achieved by redistribution of old and new resources and a heavy investment in the health sector, with great priority given to the rural and poor areas and regions of the country, and to the production of personnel, primarily of physicians.
Food-derived peroxidized fatty acids may trigger hepatic inflammation: A novel hypothesis to explain steatohepatitis
Authors: Therese Böhm, Heidi Berger, Marzieh Nejabat, Teresa Riegler, Florian Kellner, Mario Kuttke, Sandra Sagmeister, Monika Bazanella, Klaus Stolze, Anahita Daryabeigi, Nora Bintner, Michael Murkovic, Karl-Heinz Wagner, Rolf Schulte-Hermann, Nataliya Rohr-Udilova, Wolfgang Huber, Bettina Grasl-Kraupp
Journal: Journal of Hepatology (2013)
Echocardiographic Assessment of Left Ventricular Function
Authors: MIGUEL A. QUINONES, WILLIAM H. GAASCH, JAMES K. ALEXANDER
Journal: Circulation (1974)

The concept of "normalized velocity" has been applied in this study to the echocardiographic (echo) assessment of left ventricular (LV) function in 87 patients. The following normalized velocities were calculated from the ultrasound recording of LV wall motion: 1) the mean circumferential fiber shortening rate (mean V CF ), 2) the mean normalized posterior wall velocity (V PW ), and 3) the mean normalized interventricular septal velocity (V IVS ). Systolic ejection fraction (SEF), and mean (non-normalized) posterior wall velocity (PWV) were also determined. There were 19 patients with normal LV function, 5 with atrial septal defect (mean V CF , V IVS and SEF were not calculated in these patients), 16 with LV volume overload, 29 with myocardial disease, 6 with hypertrophic cardiomyopathy and 12 with coronary artery disease (CAD). Single plane cineangiographic (angio) determinations of mean V CF and SEF were obtained in 50 of the 87 patients (including all 12 patients with CAD). Mean V CF and SEF done by echo correlated very well with mean V CF and SEF done by angio in the patients without CAD ( r = 0.94 and 0.91, respectively). Mean V CF (by echo or by angio) adequately separated normal from abnormal LV function. Although correlation between mean V CF and SEF was good, mean V CF was reduced while SEF was well preserved in several patients. In spite of LV asynergy, most of the patients with CAD had good correlation between echo and angio measurements of mean V CF and SEF. Although PWV correlated with echo and angio mean V CF in the patients without CAD, the overlap of normal and abnormal values made PWV an unreliable index of LV function. In contrast, V PW proved to be a reliable indicator of LV performance in patients without LV asynergy. Agreement between V PW and mean V CF (by echo or angio) was seen in 94% of the patients; in the presence of CAD, however, greater discrepancy was seen between these two measurements. Agreement between V IVS and V PW was present in 90% of the patients without CAD, but in only 58% of the patients with CAD. The analysis of LV wall motion by echocardiography utilizing the "normalized velocity" concept appears to be a rational and practical method for evaluation of LV performance. In the absence of asynergy, V PW provides a reliable index of LV performance which may be of particular value when abnormal septal motion precludes the determination of SEF and mean V CF . In the presence of asynergy, however, mean V CF , V PW and V IVS may reflect only the performance of the visualized segment of myocardium.
Development of periarticular osteophytes in experimentally induced osteoarthritis in the dog. A study using microradiographic, microangiographic, and fluorescent bone-labelling techniques.
Authors: E M Gilbertson
Journal: Annals of the Rheumatic Diseases (1975)

(1) The development of periarticular osteophytes in experimental osteoarthritis in the dog degins as early as 3 days after induction of the disease process. (2) Development of the osteophytes is still proceeding 48 weeks after induction. (3) The common site for development of the osteophyte is at the marginal zone where synovial membrane merges with fibrocartilage. (4) At this site the osteophyte begins as a deposition of outside the existing femoral bone cortex. (5) Further deposition of new bone and resorption lead to a remodelling which ultimately produces a mature osteophyte having a trabecular bone structure and free communication with the bone marrow spaces of the femur. (6) In some dogs there is also hyperplasia of bone with remodelling which takes place beneath the cartilage of the nonarticulating face of the trochlear ridge. This develops a mature trabecular structure later in the disease process and may become confluent with the osteophyte at the marginal zone. (7) The bone changes are not confined to development of the osteophyte. The whole distal end of the femur appears to have a marked increase in bone turnover, and there is also evidence of increased bone metabolism in the contralateral limb. (8) Dye injection techniques have shown that an increase in vascularity is associated with this development of new bone, and it is suggested that the results indicate the possible importance of a vascular component in the pathogenesis of osteoarthritis.
Nitric Oxide–Independent Relaxations to Acetylcholine and A23187 Involve Different Routes of Heterocellular Communication
Authors: Iain R. Hutcheson, Andrew T. Chaytor, W. Howard Evans, Tudor M. Griffith
Journal: Circulation Research (1999)

Abstract —NO- and prostanoid-independent relaxations are generally assumed to be mediated by an endothelium-derived hyperpolarizing factor (EDHF) that has been postulated to be an arachidonic acid metabolite. Recent evidence also suggests that direct heterocellular gap junctional communication (GJC) between endothelium and smooth muscle contributes to NO-independent relaxations. In the present study we have investigated the contribution of phospholipase A 2 (PLA 2 )-linked metabolites and GJC to EDHF-type relaxations in rabbit mesenteric artery. In isolated rings preconstricted with 10 μmol/L phenylephrine in the presence of N G -nitro- l -arginine methyl ester (L-NAME) and indomethacin, acetylcholine (ACh) and the Ca 2+ ionophore A23187 evoked relaxations that were markedly attenuated by the Ca 2+ -dependent PLA 2 inhibitors 2-( p -amylcinnamoyl)amino-4-chlorobenzoic acid (3 μmol/L) and arachidonyl trifluoromethyl ketone (3 μmol/L), but were potentiated by the sulfhydryl agent thimerosal (300 nmol/L). In intact rings, relaxations to ACh were attenuated synergistically by L-NAME and Gap 27 peptide, an inhibitor of GJC, whereas ACh-evoked relaxations of “sandwich” preparations were unaffected by the peptide but were abolished by L-NAME. In both ring and sandwich preparations A23187-induced relaxations were attenuated by inhibition of PLA 2 but were insensitive to L-NAME and Gap 27 peptide. We conclude that EDHF-type relaxations of rabbit mesenteric artery to ACh and A23187 depend on a common pathway that involves activation of PLA 2 . In the case of ACh, relaxation requires transfer of a factor or factors from the endothelium to smooth muscle via gap junctions, whereas A23187 permits release directly into the extracellular space.
CYP2C9 and CYP2C19 Polymorphic Forms Are Related to Increased Indisulam Exposure and Higher Risk of Severe Hematologic Toxicity
Authors: Anthe S. Zandvliet, Alwin D.R. Huitema, William Copalu, Yasuhide Yamada, Tomohide Tamura, Jos H. Beijnen, Jan H.M. Schellens
Journal: Clinical Cancer Research (2007)

Abstract Purpose: The anticancer agent indisulam is metabolized by the cytochrome P450 of enzymes CYP2C9 and CYP2C19. Polymorphisms of these enzymes may affect the elimination rate of indisulam. Consequently, variant genotypes may be clinically relevant predictors for the risk of developing severe hematologic toxicity. The purposes of this study were to evaluate the effect of genetic variants of CYP2C9 and CYP2C19 on the pharmacokinetics of indisulam and on clinical outcome and to assess the need for pharmacogenetically guided dose adaptation. Experimental Design: Pharmacogenetic screening of CYP2C polymorphisms was done in 67 patients treated with indisulam. Pharmacokinetic data were analyzed with a population pharmacokinetic model, in which drug elimination was described by a linear and a Michaelis-Menten pathway. The relationships between allelic variants and the elimination pharmacokinetic parameters (CL, Vmax, Km) were tested using nonlinear mixed-effects modeling. Polymorphisms causing a high risk of dose-limiting neutropenia were identified in a simulation study. Results: The Michaelis-Menten elimination rate (Vmax) was decreased by 27% (P &amp;lt; 0.0001) for heterozygous CYP2C9*3 mutants. Heterozygous CYP2C19*2 and CYP2C19*3 mutations reduced the linear elimination rate (CL) by 38% (P &amp;lt; 0.0001). The risk of severe neutropenia was significantly increased by these mutations and dose reductions of 50 to 100 mg/m2 per mutated allele may be required to normalize this risk. Conclusions: CYP2C9*3, CYP2C19*2, and CYP2C19*3 polymorphisms resulted in a reduced elimination rate of indisulam. Screening for these CYP2C polymorphisms and subsequent pharmacogenetically guided dose adaptation may assist in the selection of an optimized initial indisulam dosage.
A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte
Authors: Amélie Moreau, Christelle Téruel, Michel Beylot, Valérie Albalea, Viola Tamasi, Thierry Umbdenstock, Yannick Parmentier, Antonio Sa‐Cunha, Bertrand Suc, Jean‐Michel Fabre, Francis Navarro, Jeanne Ramos, Urs Meyer, Patrick Maurel, Marie‐José Vilarem, Jean‐Marc Pascussi
Journal: Hepatology (2009)

The pregnane X receptor (PXR) initially isolated as a nuclear receptor regulating xenobiotic and drug metabolism and elimination, seems to play an endobiotic role by affecting lipid homeostasis. In mice, PXR affects lipid homeostasis and increases hepatic deposit of triglycerides. In this study, we show that, in human hepatocyte, PXR activation induces an increase of de novo lipogenesis through the up-regulation of S14. S14 was first identified as a thyroid-responsive gene and is known to transduce hormone-related and nutrient-related signals to genes involved in lipogenesis through a molecular mechanism not yet elucidated. We demonstrate that S14 is a novel transcriptional target of PXR. In addition, we report an increase of fatty acid synthase (FASN) and adenosine triphosphate citrate lyase genes expression after PXR activation in human hepatocyte, leading to an increase of fatty acids accumulation and de novo lipogenesis. RNA interference of the expression of S14 proportionally decreases the FASN induction, whereas S14 overexpression in human hepatic cells provokes an increase of fatty acids accumulation and lipogenesis. These results demonstrate for the first time that xenobiotic or drug-activated PXR promote aberrant hepatic de novo lipogenesis via activation of the nonclassical S14 pathway. In addition, these data suggest that the up-regulation of S14 by PXR may promote aberrant hepatic lipogenesis and hepatic steatosis in human hepatocytes. (HEPATOLOGY 2009.)
Biology of Endotoxin
Authors: R J Elin, S M Wolff
Journal: Annual Review of Medicine (1976)

The incidence of and mortality from gram-negative bacterial sepsis is increasing (I). The morbidity and mortality associated with infections caused by gram-negative . bacteria are considered to be related to the endotoxins present in the cell walls of these bacteria. Endotoxin-like materials have been isolated from other organisms; however, this review is concerned only with endotoxins from gram-negative bac­ teria. The chemical and biological properties of bacterial endotoxins have been under investigation for more than a century. During the past two decades more refined chemical methods for the extraction and purification of bacterial endotoxins have been developed. With the production of relatively pure materials, the biological properties have been defined in animal and human experiments. Although endotox­ ins have a myriad of biological activities that affect all systems of the body, no clear-cut molecular-biological basis for these activities is known. This review focuses on the chemical composition, methods of detection, and some of the biological properties of bacterial endotoxins, with 'particular emphasis on the effects of these agents in human beings.
Benign Ureteral Polyp in the Newborn
Authors: Douglas W. Soderdahl
Journal: JAMA (1969)

A benign ureteral polyp occurred in a newborn girl. We believe it is the youngest occurrence of ureteral tumor reported in the English literature. The patient had a mass in the left upper quadrant of the abdomen. Obstruction in the proximal part of the left ureter was confirmed by a retrograde dye injection into the ureter. A 2.0 × 0.5-cm polyp at the ureteropelvic junction was resected, and a dismemberment pyeloplasty was performed. We believe there is a developmental rather than an acquired basis for this polyp.
First-line systemic treatment of advanced stage non-small-cell lung cancer in Asia: consensus statement from the Asian Oncology Summit 2009
Authors: Ross A Soo, Benjamin O Anderson, Byoung Chul Cho, Chih-Hsin Yang, Meilin Liao, Wan-Teck Lim, Peter Goldstraw, Tony S Mok
Journal: The Lancet Oncology (2009)
Antibiotics and Nasal Steroids for Acute Sinusitis
Authors: Richard M. Rosenfeld
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence of rheumatologist-diagnosed psoriatic arthritis in patients with psoriasis in European/North American dermatology clinics
Authors: Philip J. Mease, Dafna D. Gladman, Kim A. Papp, Majed M. Khraishi, Diamant Thaçi, Frank Behrens, Robert Northington, Joanne Fuiman, Eustratios Bananis, Robert Boggs, Daniel Alvarez
Journal: Journal of the American Academy of Dermatology (2013)
Differences in collateral myocardial blood flow following gradual vs abrupt coronary occlusion
Authors: R. E PATTERSON, B. A JONES-COLLINS, R. AAMODT, Y. M. RO
Journal: Cardiovascular Research (1983)

The purpose of the present study was to test the hypothesis that collateral myocardial blood flow is higher if coronary occlusion is preceded by a brief period (45 min) of progressive, gradual stenosis, rather than by abrupt, total occlusion. Seven dogs had three coronary occlusions by a hydraulic occluder, 3 min in duration, and separated by 45 min periods of reperfusion (Group I). Microsphere blood flow was measured 1.5 min after each total occlusion was achieved. To assess the potential effects of multiple occlusions, the first and third coronary occlusions were of the same type, ie, either both abrupt or both gradually progressive over 45 min. Group II included nine dogs with abrupt total occlusion followed by microsphere blood flow measurements 1.5, 10, 20 and 45 min after occlusion, to test the effect of a 45 min duration of total occlusion on collateral flow. The results indicate that the transmural mean collateral myocardial blood flow was 33% higher 1.5 min after total occlusion if the total occlusion was preceded by gradual, progressive coronary stenosis over 45 min (0.093 ± 0.085 ml·min−1·g−1) compared with the abrupt occlusion (0.070 ± 0.062 ml·min−1·g−1, P<0.05). The higher flow was not distributed preferentially to one transmural layer and was not explained by haemodynamic changes between occlusions. The change in collateral flow between abrupt and gradual occlusions (randomised sequence) was not the result of performing sequential occlusions because the transmural mean collateral blood flow did not differ between the first and third occlusions which were both of the same type. Further the difference between abrupt and gradual occlusions is not explained by the longer period of reduced coronary flow to stimulate collaterals during gradual stenosis because transmural mean collateral myocardial blood flow did not increase in Group II dogs between 1.5 and 45 min after abrupt, total occlusion (0.167±.039 to 0.161 ±0.041 ml·min−1·g−1). The mechanism of this higher collateral blood flow after gradual vs abrupt occlusion cannot be determined from these experiments, but these results should be considered in interpreting and designing experiments involving more than one coronary occlusion. The 33% higher collateral flow after gradual occlusion is small but might be expected to limit the severity of ischaemic injury and may have potential therapeutic implications for patients in whom dynamic processes of coronary occlusion are operative.
Mental Retardation: Diagnosis and Treatment
Authors: George Mora
Journal: JAMA (1970)

The editor of this volume, a neurologist, has gathered here 14 chapters on various aspects of mental deficiency. With few exceptions, the seventeen contributing authors are from the University of Missouri and academic institutions in Kansas. After an introductory chapter by the editor, the initial three chapters assess the retarded child from the neurological, psychological, and educational viewpoint. The succeeding section is devoted to treatment of pseudoretardation, of communication disorders, of metabolic and endocrine causes, of conditions requiring surgery, and of pseudoretardation associated with epilepsy, respectively. Of the final five chapters, three discuss various aspects of management, training, and institutionalization of the retarded, one discusses genetic counseling and one discusses degenerative diseases causing mental retardation. The presentation is not too technical and each chapter is divided into subsections. A number of tables are scattered throughout the text. An essential bibliography is given at the end of some of the chapters
Anaphylaxis in Australia
Authors: Rebecca Voelker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal