THE EFFECTIVENESS OF REPLACEMENT THERAPY IN ACHLORHYDRIA
Authors: Alfred E. Koehler, Emanuel Windsor
Journal: Annals of Internal Medicine (1943)

Article1 February 1943THE EFFECTIVENESS OF REPLACEMENT THERAPY IN ACHLORHYDRIAALFRED E. KOEHLER, M.D., PH.D., EMANUEL WINDSOR, M.S.ALFRED E. KOEHLER, M.D., PH.D.Search for more papers by this author, EMANUEL WINDSOR, M.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-18-2-182 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe diminution or absence of hydrochloric acid in the stomach is not an infrequent occurrence. Among representative studies are those of Bennett and Ryle,1who in 1921 observed that 4 per cent of 100 normal, healthy male medical students had achlorhydria, and those made by Vanzant, Alvarez and associates2who in 1932 found achlorhydria in patients without gastric disease in from 25 to 35 per cent between the ages of 60 to 70 years. More recently Ruffin and Dick3studied the gastric acidity of 2877 patients and found lack of acid in 10 per cent of the total and in...References1. BENNETTRYLE TIJA: Studies in gastric secretion. V. A study of normal gastric function based on the investigation of one hundred healthy men by means of the fractional method of gastric analysis, Guy's Hosp. Rep., Series 4, 1921, i, 286. Google Scholar2. VANZANTALVAREZEUSTERMANDUNNBERKSON FRWGGBHLJ: The normal range of gastric acidity from youth to old age: an analysis of 3746 records, Arch. Int. Med., 1932, xlix, 345. CrossrefGoogle Scholar3. RUFFINDICK JMM: The significance of gastric acidity after histamine stimulation: a statistical study of 2877 gastric analyses, ANN. INT. MED., 1939, xii, 1940. Google Scholar4. BUSSABARGERFREEMANIVY RASAC: The experimental production of severe homogenous osteoporosis by gastrectomy in puppies, Am. Jr. Physiol., 1938, cxxi, 137. Google Scholar5. 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SHOHLKING ATJH: Determination of the acidity of gastric contents. II. The colorimetric determination of free hydrochloric acid, Bull. Johns Hopkins Hosp., 1920, xxxi, 158-162. Google Scholar11. HAGGARDGREENBERG HWLA: The influence of certain fruit juices on gastric function, Am. Jr. Digest. Dis., 1941, viii, 163. CrossrefGoogle Scholar12. NORTHROP JH: The effect of various acids on the digestion of protein by pepsin, Jr. Gen. Physiol., 1919, i, 607. CrossrefGoogle Scholar13. LOEB J: Proteins and the theory of colloidal behavior, 1922, McGraw-Hill Book Company, New York, p. 78. Google Scholar14. VAN SLYKEBAKER LIJC: The preparation of pure casein, Jr. Biol. Chem., 1918, xxxv, 127. Google Scholar15. HOLTLA MERCHOWN LEVKHB: Studies in calcification. I. The solubility product of secondary and tertiary calcium phosphate under various conditions, Jr. Biol. Chem., 1925, lxiv, 509. CrossrefGoogle Scholar16. HOFFMAN WS: The micro determination of fixed bases, calcium and sulfates in urine, Jr. Biol. Chem., 1931, xciii, 787. CrossrefGoogle Scholar17. MELNICKROBINSONFIELD DWDH: Fate of thiamine in the digestive secretions, Jr. Biol. Chem., 1941, cxxxviii, 49. CrossrefGoogle Scholar18. SPENCERMEYERREHFUSSHAWK WHGPMEPB: Gastro-intestinal studies. XII. Direct evidence of duodenal regurgitation and its influence upon the chemistry and function of the normal human stomach, Am. Jr. Physiol., 1916, xxxix, 459-479. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Santa Barbara, California*Read at the St. Paul meeting of the American College of Physicians April 24, 1942.From the Santa Barbara Cottage Hospital and The Sansum Clinic, Santa Barbara, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byManagement of upper gastrointestinal symptoms in patients with autoimmune gastritisHow Often is There Value in the Giving of Hydrochloric Acid?Recent Advances in Pharmacology 1 February 1943Volume 18, Issue 2Page: 182-192KeywordsAchlorhydriaHospitalsHydrochloric acidPatient advocacyStomach ePublished: 1 December 2008 Issue Published: 1 February 1943 PDF downloadLoading ...