WALDENSTRÖM'S MACROGLOBULINEMIA: CLINICAL PATHOLOGICAL CONFERENCE AT THE NATIONAL INSTITUTES OF HEALTH
Authors: C G ZUBROD, T F HILBISH, J L FAHEY, T F DUTCHER, F A FOX, E F OSSERMAN
Journal: Annals of Internal Medicine (1959)

Clinical Pathological Conference1 April 1959WALDENSTRÖM'S MACROGLOBULINEMIA: CLINICAL PATHOLOGICAL CONFERENCE AT THE NATIONAL INSTITUTES OF HEALTHCHARLES G. ZUBROD, M.D., T. F. HILBISH, M.D., JOHN L. FAHEY, M.D., THOMAS F. DUTCHER, M.D., FREDERICK A. FOX, M.D., ELLIOTT F. OSSERMAN, M.D.CHARLES G. ZUBROD, M.D.Search for more papers by this author, T. F. HILBISH, M.D.Search for more papers by this author, JOHN L. FAHEY, M.D.Search for more papers by this author, THOMAS F. DUTCHER, M.D.Search for more papers by this author, FREDERICK A. FOX, M.D.Search for more papers by this author, ELLIOTT F. OSSERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-4-1010 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Charles G. Zubrod: The clinical part of this Clinicopathologic Conference concerns a rather unusual situation of abnormal protein production. We have invited Dr. Elliott Osserman, one of the country's authorities on abnormal proteins, to help us with this problem. Dr. Osserman is on the staff of Francis Delafield Hospital, Columbia University, New York City.The presentation of this conference will not follow the usual pattern. Dr. Osserman will start with some comments about the protocol. After that, we shall present three additional bits of evidence which have been collected since this particular patient died. Then Dr. Osserman will attempt...Bibliography1. FaheyMcCoyGoulian JLPFM: Chromatography of serum proteins in normal and pathologic sera: the distribution of protein-bound carbohydrate and cholesterol, siderophilin, thyroxin-binding protein, B12-binding protein, alkaline and acid phosphatases, radio-iodinated albumin and myeloma proteins, J. Clin. Investigation 37: 272, 1958. MedlineGoogle Scholar2. Fahey JL: Unpublished observations. Google Scholar3. SoberPeterson HAEA: Protein chromatography on ion exchange cellulose, Federation Proc. 17: 1116, 1958. MedlineGoogle Scholar4. LaurellLaurellWaldenström CHJ: Glycoproteins in serum from patients with myeloma, macroglobulinemia and related conditions, Am. J. Med. 22: 24, 1957. CrossrefMedlineGoogle Scholar5. PernisWuhrmannWunderly BFC: Aminoacid composition of macroglobulins in four cases of macroglobulinemia, Acta haemat. 11: 309, 1954. CrossrefMedlineGoogle Scholar6. Mandemavan der SchaafHuisman EPCTH: Investigations on the amino acid composition of a macroglobulin and a cryoglobulin, J. Lab. and Clin. Med. 45: 261, 1955. MedlineGoogle Scholar7. McFarlaneDoveySlackPapastamatis ASAHGSC: An unusual case of hyperglobulinemia, J. Path. and Bact. 64: 335, 1952. CrossrefMedlineGoogle Scholar8. KorngoldVan Leeuwen LG: Macroglobulinemia. I. The antigenic relationship of pathological macroglobulins to normal gamma globulins, J. Exper. Med. 106: 467, 1957. CrossrefMedlineGoogle Scholar9. Fraenkel-ConratHarrisLevy HJIAL: Recent developments in techniques for terminal and sequence studies in peptides and proteins, Methods of Biochemical Analysis 2: 359, 1955. MedlineGoogle Scholar10. BichelBingHarboe JIN: Another case of hyperglobulinemia and affection of the central nervous system, Acta med. Scandinav. 138: 1, 1950. CrossrefMedlineGoogle Scholar11. TischendorfHartmann WF: Makroglobulinaemie (Waldenström) mit gleichzeitiger Hyperplasie der Gewebmastzellen, Acta haemat. 4: 374, 1950. CrossrefMedlineGoogle Scholar12. DeutschMorton HFJI: Dissociation of human serum macroglobulins, Science 125: 600, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 9, 1959.This is an edited transcription of a clinical pathological conference at the Clinical Center, Bethesda, Maryland, by the National Cancer Institute, National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare.Requests for reprints should be addressed to Charles G. Zubrod, M.D., National Institutes of Health, Bethesda 14, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMacroglobulinemia or Multiple MyelomaChromatographic Studies of Anomalous γ-, β2-, and Macroglobulins and Normal γ-Globulins in Myeloma and Macroglobulinemic SeraCase 18-1961Macroglobulinaemia Waldenström: A Case with Haemolytic Syndrome and Involvement of the Nervous SystemA CASE OF ANÆMIA ASSOCIATED WITH MACROGLOBULINÆMIA 1 April 1959Volume 50, Issue 4Page: 1010-1027KeywordsAnemiaMedical servicesMultiple myelomaPeriodic acid SchiffPrevention, policy, and public healthProteinsUltracentrifugation ePublished: 1 December 2008 Issue Published: 1 April 1959 PDF downloadLoading ...