tbuckley/cabot-search huggingface dataset:
Abstract 1246: ELK-1 regulates interferon-alpha8 expression via a polymorphic region in the interferon-alpha8 promoter associated with outcome of glioma patients
Authors: Gary Kohanbash, Eiichi Ishikawa, Mitsugu Fujita, Kayla Mckaveney, Masashi Sakaki, Michael Scheurer, Melissa Bondy, Saumendra Narayan Sarkar, Hideho Okada
Journal: Cancer Research (2012)

Abstract Several studies have demonstrated a significant immunological impact of single nucleotide polymorphisms in Interferon (IFN)-related genes, such as Toll-Like Receptor (TLR)3 and TLR4. We recently reported that patients with the AA-genotype of a SNP in the IFN-alpha8 (IFNA8) promoter region was associated with better overall survival of patients with WHO grade 2 and 3 gliomas compared to patients with the AC-genotype. Based on these observations we hypothesized that the A-allele in the promoter of IFNA8 allows for enhanced transcription factor binding and expression levels of IFNA8 compared with the C-allele. Analyses of THP-1 cells transfected with a luciferase gene downstream of a short sequence containing the SNP in the IFNA8 promoter demonstrated that the A-allele results in enhanced promoter activity. In silico analysis suggested c-Krox and ELK-1 as likely transcription factors that bind to the IFNA8 polymorphic region. Co-transfection of plasmids encoding the c-Krox or ELK-1 and the luciferase constructs revealed that ELK-1 negatively regulated promoter activity with the A but not C-allele, while c-Krox could not affect activity regardless of allele. Consistently, transfection of ELK-1 siRNA into THP-1 cells resulted in increased promoter activity. To further identify factors that contribute to the enhanced A-allele promoter activity we assessed the effect drugs that inhibit intracellular signaling pathways: PD98059 for inhibiting MEK/ERK, SB203580 a p38 inhibitor, and PPase-2B for de-phosphorylating small molecules. Use of any of the inhibitor resulted in decreased activity of the A-allele promoter activity indicating that multiple proteins or a protein common to multiple pathways seems to be involved. Taken together our data demonstrates that the A-allele in the IFNA8 promoter, which is associated with better glioma patient survival, allows for enhances promoter activation which is negatively regulated by ELK-1 and further regulate by multiple signaling pathways. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1246. doi:1538-7445.AM2012-1246
Sensorimotor EEG rhythms and their connection to local/global neocortical dynamic theory
Authors: Colin Andrew
Journal: Behavioral and Brain Sciences (2000)

The EEG activity recorded from the human sensorimotor cortical area exhibits rhythmic activity covering a broad range of frequencies, including alpha, mu, beta, and gamma (40-Hz) rhythms. This commentary elaborates on connections between these sensorimotor rhythms and Nunez's neocortical dynamic theory.
Picture Reports: Influenza virus, Santa Claus, or a mouse playing tennis?
Authors: B. Getty
Journal: BMJ (1984)

Influenza virus, Santa Claus, or a mouse playing tennis?We have all lain on our backs, looked up at the clouds, and imagined all sorts of creatures there.Sometimes the same may happen with electron microscopy, and I recently produced this electron micrograph of an influenza virus.My colleagues and I have seen it variously as a caveman wielding a club, John
Role of microRNAs in cardiac hypertrophy, myocardial fibrosis and heart failure
Authors: De-li Dong, Bao-feng Yang
Journal: Acta Pharmaceutica Sinica B (2011)

MicroRNAs (miRNAs) are endogenous small non-coding RNA molecules that post-transcriptionally regulate gene expression. MiRNA expression and function in heart disease remain to be determined but modulation of miRNA expression in vivo has revealed that miRNAs play an important role in controlling heart function and structure. In fact, abnormal expression of miRNAs may initiate and contribute to the progress of heart disease. Here, we summarize the literature relating to the involvement of miRNAs in cardiac hypertrophy, myocardial fibrosis and heart failure.
Trades Unionism Among Asylum Employes.
Authors: V. H. PODSTATA
Journal: JAMA (1904)

Dunning, Ill., Dec. 23, 1903. <h3>To the Editor:</h3> —I presume it is well known, from the notices that have appeared in the daily press of Chicago, that there is established at Dunning a union of attendants and nurses, organized on the same basis as regular labor organizations and affiliated with the Chicago Federation of Labor. It is also a well-known fact that the attendants and nurses, as well as other employes at Dunning, are under the protection of civil service, the protection being so strong as to absolutely prevent me from either hiring or discharging an employe. The attendants have made a demand for a uniform scale of wages, much higher than the present one, and in spite of the fact that the average pay allowed to attendants and nurses at Dunning is now somewhat higher than the average in the state institutions in Illinois, and in fact higher than
211 Synergic action of insulin-like growth factor I (IGF-I) and interferon-α (IFNα) co-administration in experimental cirrhosis
Authors: I. Castilla-Cortáza, E. Tutau, J.E. Puche, M. García-Fernández, E. Mirpur, A. Castilla, J. Quiroga, S. González-Barón, J. Prieto
Journal: Journal of Hepatology (2006)
Louse-borne Relapsing Fever in Persia
Authors: R. I. Bodman, I. S. Stewart
Journal: BMJ (1948)

Case 16.-A man aged 42 had had a dragging left leg and slightly ataxic gait for six years.He was found to haxe left ankle clonus, brisk reflexes, and bilateral extensor responses.tfubarine in doses of 20 mg. and 30 mg. produced severe side- effects, blurring of vision, and drunkenness, great ataxia, but no objective improvement in gait.The drug was discontinued at patient's own request.Case 17.-A woman aged 44 had had disseminated sclerosis for 10 years.Brisk tendon reflexes, bilateral extensor plantar responses, and spastic paraplegia were present.She was able to walk a few steps, but had not been out of her house for three "Years.Tubarine in 30-mg.doses did not give any relief but made the patient giddy and more ataxic.Our thanks are due to Dr. H. S. Pemberton and Dr. Leslie Cunninglham for help in
Poliomyelitis in developing countries
Authors: D. Morley
Journal: BMJ (1978)

parison we recorded our results in the same way as Drs Lunn and Johnson.Forty-four of the 60 persons with positive Mantoux tests had a positive and 10 a doubtful tine test.We even found 9",, positive tine tests in Mantoux-negative patients, a fact we explain by the difficulty of strictly intracutane- ous application of the Mantoux test in older persons with very thin skin.In our practice the tine test is an accurate and easily performed screening test for tuberculosis.
DIFFERENCES OF OPTICAL COHERENCE TOMOGRAPHIC FINDINGS BETWEEN EXCIMER LASER AND CUTTING BALLOON ANGIOPLASTY FOR IN-STENT RESTENOSIS LESION
Authors: Masami Nishino, Takeshi Masaki, Naoki Mori, Takahiro Yoshimura, Daisuke Nakamura, Yasuharu Lee, Masahiko Hara, Shinpei Nakatani, Masayuki Taniike, Nobuhiko Makino, Hiroyasu Kato, Yasuyuki Egami, Ryu Shutta, Hitoshi Yamaguchi, Jun Tanouchi, Yoshio Yamada
Journal: Journal of the American College of Cardiology (2010)
Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness
Authors: Tobias Wollersheim, Janine Woehlecke, Martin Krebs, Jida Hamati, Doerte Lodka, Anja Luther-Schroeder, Claudia Langhans, Kurt Haas, Theresa Radtke, Christian Kleber, Claudia Spies, Siegfried Labeit, Markus Schuelke, Simone Spuler, Joachim Spranger, Steffen Weber-Carstens, Jens Fielitz
Journal: Intensive Care Medicine (2014)
Increased Prevalence of Diabetes and Obesity in Patients With Salivary Gland Tumors
Authors: Zsuzsanna Suba, József Barabás, György Szabó, Daniel Takács, Márta Ujpál
Journal: Diabetes Care (2005)

It has been recently revealed that type 2 diabetes is a risk factor for tumorous proliferation at different sites (1). Breast and colon cancers were the first tumors for which an epidemiological correlation was demonstrated between this glucose metabolism disorder and tumor incidence (2). The “western lifestyle,” first of all obesity, increases the risk of not only type 2 diabetes but also of overall cancer promotion (3).

Swelling of the parotids and a decreased salivary flow rate caused by degenerative alterations in the acinar cells are common concomitants of diabetes and dyslipidemias (4,5). However, no data …
Australia's free trade deal with US hangs in balance on drugs
Authors: Bob Burton
Journal: BMJ (2004)

Junior hospital doctors throughout Europe were supposed to start a new, shorter, 58 hour week from this month.Aimed at improving their working livesand their patients' safety-the European directive aims to reduce the limit further to just 48 hours by 2009.But despite the new rules, many doctors will continue to work long hours.United Kingdom: A recent survey of 100 NHS chief executives by the NHS Confederation, which represents NHS management, showed that 16% did not expect their trusts to have complied with the European Working Time Directive by 1 August.Junior doctors could take their employers to employment tribunals, and hospitals will be liable to fines of up to £5000 ($9200; €7600) from the Health and Safety Executive each time they break the directive.The BMA said that it will support UK doctors who take legal action against employers that do not limit their working hours to those set out in the directive.The NHS has been struggling to meet the requirements of the new directive, but it is not alone in failing to do so fully.Austria: Compliance with
Selective elimination of anti-DNA antibody-producing cells by antiidiotypic antibody conjugated with neocarzinostatin.
Authors: T Sasaki, T Muryoi, O Takai, E Tamate, Y Ono, Y Koide, N Ishida, K Yoshinaga
Journal: Journal of Clinical Investigation (1986)

A new strategy was shown for the manipulation of autoantibody production in humans. Antiidiotypic antibody to human anti-DNA autoantibody was conjugated with neocarzinostatin (NCS), a cytotoxic agent, by using N-succimidyl 3-(2-pyridyldithio) propionate as a coupling agent. Human B cell clones, which produce anti-DNA autoantibodies, were killed by in vitro treatment with antiidiotype (Id)-NCS conjugates, while clones expressing an Id with irrelevant specificity were unaffected. These results indicate that treatment with anti-Id-NCS conjugates can act as a potent and specific means of generating immunosuppression of autoantibody production. This approach will have a significant advantage in aborting clones that are not effectively suppressed for the autoantibodies by anti-Id antibodies alone, and will result in a potential therapeutic treatment for systemic lupus erythematosus.
Translational research: are we on the right track?
Authors: Charles L. Sawyers
Journal: Journal of Clinical Investigation (2008)

It is a great honor and privilege to stand before you today to deliver the 2008 American Society of Clinical Investigation Presidential Address. I have chosen a controversial topic — and one that I know intimately — that challenges the standard operating procedures of our profession at many levels. While no one will object to the goal of applying basic biomedical research insights to clinical medicine, we can certainly debate the methods by which we encourage this process. Translational medicine has rapidly emerged as the rallying cry for many stakeholders in biomedical research, most notably the Congress and the public, who rightfully want to hold us accountable for their investment of taxpayer dollars into our enterprise. Major funding sources have channeled significant portions of their budgets into new translational research programs, many of which prescribe specific projects and even link delivery of resources to completion of defined milestones. Is this the best way to ensure bench-to-bedside science? Can translational research be directed from headquarters?
Adaptation of Houses for Home Dialysis
Authors: V. Parsons, A. T. Mellowship
Journal: BMJ (1971)

Maliciously minded persons might suspect that the orthopaedic consultant, by remain- ing "in charge" and having four experts to do the work for him, was motivated by the pecuniary considerations arising from the lucrative fringe benefit of medicolegal re- porting, but you and I, Sir, know that such mundane considerations would never moti- vate the members of a learned profession.-Iam, etc.,
Cardiac Effects of Tyramine
Authors: John C. Holmes, Noble O. Fowler
Journal: Circulation Research (1962)

The cardiac effects of tyramine ( p -hydroxyphenylethylamine) were studied in 22 dog heart-lung preparations. In six uncontrolled rate preparations, tyramine 250 to 500 µg. increased the heart rate an average of 21 per cent. In controlled rate preparations, tyramine 100 to 250 µg. consistently increased ventricular contractile force, cardiac output, and blood pressure; there was a consistent decrease of right and left atrial pressures. Comparable hemodynamic effects were produced by 1 to 2.5 µg. of levarterenol, except that the effects of tyramine tended to be of longer duration and were less likely to be followed by cardiac depression. It is concluded that tyramine has significant positive inotropic and chronotropic effects in the dog heart-lung preparation. In three animals pretreated with reserpine, tyramine had little effect. Its action appears to depend to a large extent upon the presence of myocardial catecholamines.
The Morbidity of Cardiac Nondisease in Schoolchildren
Authors: Abraham B. Bergman, Stanley J. Stamm
Journal: New England Journal of Medicine (1967)

CLINICAL medicine concerns itself mainly with the diagnosis and treatment of disease. Most physicians would agree, however, that their job properly entails promotion of positive health. The distinction is more than a semantic one. Too many people exist in an unnecessary limbo where they either perceive themselves or are perceived by others to have a nonexistent disease. Such a person may be as disabled or "unhealthy" as if he actually had the disease. In a classic satiric article, Meador1 proposed an organized "science of nondisease" to deal with this sadly neglected problem.Prevalence data on nondisease are lacking; appropriate epidemiologic . . .
Fine Structure of Developing and Adult Intercalated Discs in Rat Heart
Authors: H. Melax, T. S. Leeson
Journal: Cardiovascular Research (1969)

Journal Article Fine Structure of Developing and Adult Intercalated Discs in Rat Heart Get access Haukur Melax, Haukur Melax From the Department of Anatomy, University of Alberta, Edmonton, Alberta, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas S. Leeson Thomas S. Leeson From the Department of Anatomy, University of Alberta, Edmonton, Alberta, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 3, Issue 3, July 1969, Pages 261–267, https://doi.org/10.1093/cvr/3.3.261 Published: 01 July 1969 Article history Received: 23 January 1969 Published: 01 July 1969
Deciphering Harm Measurement
Authors: Gareth Parry, Amelia Cline, Don Goldmann
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 777: GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance
Authors: Kamlesh S. Sodani, Amit K. Tiwari, Satyakam Singh, Atish Patel, Zhijie Xiao, Junjiang Chen, Yueli Sun, Tanaji T. Talele, Zhe-Sheng Chen
Journal: Cancer Research (2012)

Abstract The overexpression of ATP-binding cassette (ABC) transporters often lead to the development of multidrug resistance (MDR), resulting in chemotherapy failure. Previously, we reported that lapatinib (GW572016), a human epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinase inhibitor (TKI), modulates ABC subfamily B member 1 (ABCB1)- and ABC subfamily G member 2 (ABCG2)-mediated MDR in cancer cells. In the present study, we conducted experiments to determine if GW583340 and GW2974; structural analogues of lapatinib; could reverse ABCB1- and ABCG2-mediated MDR. Our results showed that both GW583340 and GW2974 significantly sensitized MDR cells overexpressing ABCB1 to their anticancer substrates as well as ABCG2 overexpressing cells to its substrates. Subsequently, both GW583340 and GW2974 significantly increased intracellular accumulation of [3H]-paclitaxel in ABCB1 overexpressing cells. Similarly, both GW583340 and GW2974 significantly increased accumulation of [3H]-mitoxantrone in ABCG2 overexpressing cells. In addition, GW583340 and GW2974 significantly inhibited ABCG2-mediated transport of methotrexate in ABCG2 overexpressing membrane vesicles. Moreover, there was no significant change in the expression levels of ABCB1 and ABCG2 in the cell lines exposed to 5 μM of either GW583340 or GW2974 for 3 days. In addition, docking model predicted the binding conformation of GW583340 and GW2974 within the large cavity of the transmembrane region of homology modeled human ABCB1. We conclude that GW583340 and GW2974, at clinically achievable concentrations reverse ABCB1- and ABCG2-mediated MDR by directly blocking the drug efflux function of these transporters. These findings may be useful in developing cancer combinational therapy with EGFR TKIs in the future. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 777. doi:1538-7445.AM2012-777
Control Programs for Heroin Addiction
Authors: J. T. Nix
Journal: JAMA (1970)

To the Editor.—  I want to congratulate the editorial staff and the officers ofThe Journalfor publishing under letters Control Programs for Heroin Addiction, ( 210: 2094, 1969). Dr. Neumann has shown great courage in what I know to be correct exposure of the enormous funds wasted in treating addicts. The exposure of disposition of funds dedicated by the taxpayer for the control of heroin addiction and crime on the street will be exposed in news media within a matter of weeks. The actions of some men of medicine in this area in the past has not been that of men of integrity. Hundreds of millions of dollars have been used to finance programs for control of narcotic addiction known to be worthless, while the methadone program of Dole and Nyswander has received little or no federal funding. As a matter of fact, it would seem that the addict is
Studies on the Microsomal Metabolism and Binding of Polybrominated Biphenyls (PBBs)
Authors: Ghazi A. Dannan, Robert W. Moore, Steven D. Aust
Journal: Environmental Health Perspectives (1978)

The metabolism of polybrominated biphenyls (PBBs) was studied in vitro by using rat liver microsomes in the presence of NADPH and atmospheric 02.Quantitative recoveries of all PBBs were obtained after incubations with control or 3-methylcholanthrene (MC) induced microsomes.Of the twelve major com- ponents, losses of only peaks I (2,4,5,2',5'-pentabromobiphenyl) and 3 (a hexabromobiphenyl) were observed following incubations with microsomes from phenobarbital (PB)-or PBBs-pretreated rats.Of seven structurally identified PBB components, only peak 1 has a bromine-free para position.Peaks 1, 2, and 5 all have two adjacent unsubstituted carbons, yet only peak I is metabolized.Of two di- bromobiphenyl model compounds studied, the 2,2'-congener was very rapidly metabolized by PB-induced microsomes whereas its 4,4'-isomer was not.These results suggest that the presence of a free para position is required for the metabolism of brominated biphenyls.Of lesser importance appears to be the number of bromines or the availability of two adjacent unsubstituted carbons.In vivo evidence for the metabolism of peaks 1 and 3 was also provided by their drastically diminished levels in liver and milk extracts.When a '4C-PBB mixture consisting almost exclusively of peaks 4 (2,4,5,2',4',5'-hexa- bromobiphenyl) and 8 (2,3,4,5,2'4',5'-heptabromobiphenyl) was incubated with PB-or PBBs-induced microsomes and NADPH, only traces of radioactivity remained with the microsomes after extensive extraction.However, less radioactivity was bound to microsomes from MC pretreated or especially control rats.No radioactivity was bound to exogenous DNA included in similar microsomal incubations, regardless of the type of microsomes used.Under the same conditions, [3H]-benzo[a]pyrene metabolites were bound to DNA, and PBB-induced microsomes enhanced this binding more than six-fold.
675 THE RELATIONSHIP OF SERUM IP-10 LEVELS TO HISTOLOGICAL ACTIVITY, SERUM ALT, HCVRNA TITERS AND HCV GENOTYPE IN CHRONIC HCV INFECTION
Authors: S.K. Yoon, C.R. You, J.D. Kim, J.H. Kwon, S.W. Jeong, S.W. Choi, N.I. Han, C.D. Lee, Y.S. Lee
Journal: Journal of Hepatology (2008)
Clofarabine, idarubicin, and cytarabine (CIA) as frontline therapy for patients ≤60 years with newly diagnosed acute myeloid leukemia
Authors: Aziz Nazha, Hagop Kantarjian, Farhad Ravandi, Xuelin Huang, Sangbum Choi, Guillermo Garcia‐Manero, Elias Jabbour, Gautam Borthakur, Tapan Kadia, Marina Konopleva, Jorge Cortes, Alessandra Ferrajoli, Steve Kornblau, Naval Daver, Naveen Pemmaraju, Michael Andreeff, Zeev Estrov, Min Du, Mark Brandt, Stefan Faderl
Journal: American Journal of Hematology (2013)

Clofarabine is a second generation nucleoside analogue with activity in adults with acute myeloid leukemia (AML). A phase I trial of clofarabine, idarubicin, and cytarabine (CIA) in relapsed and refractory AML had shown an overall response rate (ORR) of 48%. To explore this combination further, we conducted a phase II study of (CIA) in patients with newly diagnosed AML ≤60 years. Patients ≥18-60 years with AML and adequate organ function were enrolled. Induction therapy consisted of clofarabine (C) 20 mg m⁻² IV daily (days 1-5), idarubicin (I) 10 mg m⁻² IV daily (days 1-3), and cytarabine (A) 1 g m⁻² IV daily (days 1-5). Patients in remission received up to six consolidation cycles (C 15 mg m⁻² × 3, I 8 mg m⁻² × 2, and A 0.75 g m⁻² × 3). Fifty-seven patients were evaluable. ORR was 79%. With a median follow up of 10.9 months, the median overall survival (OS) was not reached, the median event-free survival (EFS) was 13.5 months. Most toxicities were ≤grade 2. Four week mortality was 2%. In subgroup analysis, patients ≤40 years had better OS (P = 0.04) and EFS (P = 0.04) compared to patients >40 years. Compared to historical patients treated with idarubicin and cyarabine (IA), the OS and EFS were significantly longer for CIA treated patients. In multivariate analysis, CIA retained its favorable impact on OS compared to IA. Thus, CIA is an effective and safe therapy for patients ≤60 years with newly diagnosed AML.