tbuckley/cabot-search huggingface dataset:
DIFFERENT IN PATTERN OF LATE RESTENOSIS BETWEEN LESIONS WITH AND WITHOUT LATE LOSS AT 8-MONTH FOLLOW-UP ANGIOGRAPHY
Authors: Nehiro Kuriyama, Yoshio Kobayashi, Kensaku Nishihira, Yusuke Fukushima, Youhei Inoue, Tatsuya Nakama, Daigo Mine, Shuichirou Sagara, Katsumasa Nomura, Keiichi Ashikaga, Akihiko Matsuyama, Yoshisato Shibata
Journal: Journal of the American College of Cardiology (2011)
The use of biodegradable scaffold as an alternative to silicone implant arthroplasty for small joint reconstruction: An experimental study in minipigs
Authors: Eero Waris, Nureddin Ashammakhi, Mauri Lehtimäki, Riitta-Mari Tulamo, Minna Kellomäki, Pertti Törmälä, Yrjö T. Konttinen
Journal: Biomaterials (2007)
Diverse Biological Effect and Smad Signaling of Bone Morphogenetic Protein 7 in Prostate Tumor Cells
Authors: Shangxin Yang, Chen Zhong, Baruch Frenkel, A. Hari Reddi, Pradip Roy-Burman
Journal: Cancer Research (2005)

Abstract We found that bone morphogenetic protein (BMP) 7, a member of the BMP family, was strikingly up-regulated during the development of primary prostatic adenocarcinoma in the conditional Pten deletion mouse model. To determine the relevance of this finding to human prostate cancer, we examined the expression of BMPs and BMP receptors (BMPR) as well as the responsiveness to recombinant human BMP7 in a series of human prostate tumor cell lines. All prostatic cell lines tested expressed variable levels of BMP2, BMP4, and BMP7 and at least two of each type I and II BMPRs. In all cases, BMP7 induced Smad phosphorylation in a dose-dependent manner, with Smad5 activation clearly demonstrable. However, the biological responses to BMP7 were cell type specific. BPH-1, a cell line representing benign prostatic epithelial hyperplasia, was growth arrested at G1. In the bone metastasis-derived PC-3 prostate cancer cells, BMP7 induced epithelial-mesenchymal transdifferentiation with classic changes in morphology, motility, invasiveness, and molecular markers. Finally, BMP7 inhibited serum starvation–induced apoptosis in the LNCaP prostate cancer cell line and more remarkably in its bone metastatic variant C4-2B line. Each of the cell lines influenced by BMP7 was also responsive to BMP2 in a corresponding manner. The antiapoptotic activity of BMP7 in the LNCaP and C4-2B cell lines was not associated with a significant alteration in the levels of the proapoptotic protein Bax or the antiapoptotic proteins Bcl-2, Bcl-xl, and X-linked inhibitor of apoptosis. However, in C4-2B cells but not in LNCaP cells, a starvation-induced decrease in the level of survivin was counteracted by BMP7. Taken together, these findings suggest that BMPs are able to modulate the biological behavior of prostate tumor cells in diverse and cell type–specific manner and point to certain mechanisms by which these secreted signaling molecules may contribute to prostate cancer growth and metastasis.
The Medical Expert
Authors: Gene L. Usdin
Journal: New England Journal of Medicine (1957)

WHEREAS the medical profession has attained increasing respect among the laity in the last several decades, no such progress has occurred in the important area of legal medicine. In many cases, through myriad causes, some of which are discussed below, physician has been pitted against physician in courts of law. The results have not been particularly salutary for the medical profession. Physicians arraigned on opposite sides of a controversy frequently give the impression of medical disagreement when in reality the interpretations may reflect no more than the range of conservatism and liberality, indicating basic agreement rather than disagreement. Efforts are . . .
The Western Medical Tradition: 800 BC to AD 1800
Authors: P. Corsi
Journal: BMJ (1995)

Lawrence I Conrad, Michael Neve, Vivian Nutton, Roy Porter, Andrew Wear Cambridge University Press, pounds sterling24.95, pp 556 ISBN 0 521 47564 3

Covering 2600 years of Western medical history in less than 500 pages could be regarded as an accomplishment in itself—and the mere listing of the contents of The Western Medical Tradition would take up all of the space allotted to this review.

I will therefore merely state that the book provides a survey of medical doctrines and practices; of medical and professional institutions and patients; of professional rivalries, achievements, and failures; of the beliefs concerning health and disease of those who could write …
Reply to Maurizio Serati, Stefano Uccella and Stefano Salvatore's Letter to the Editor re: Annette Kuhn, Caroline Eggeman, Fiona Burkhard and Michael D. Mueller. Correction of Erosion after Suburethral Sling Insertion for Stress Incontinence: Results and Related Sexual Function. Eur Urol 2009;56:371–7
Authors: Annette Kuhn
Journal: European Urology (2008)
Clinical and radiological survey of the incidence of osteoarthrosis among obese patients.
Authors: R H Goldin, L McAdam, J S Louie, R Gold, R Bluestone
Journal: Annals of the Rheumatic Diseases (1976)

Twenty-five grossly obese males were investigated for evidence of osteoarthrosis. A roentgenological survey of multiple joints obtained from 22 of these patients showed few significant degenerative changes. 6 patients (20%) had previously incurred traumatic rents in their menisci necessitating meniscectomy. Our results refute previous claims that obesity is a factor in the genesis of osteoarthrosis but do indicate that obese individuals are more predisposed to traumatic injury of the knee.
Myocardial Involvement Is Very Frequent Among Patients Affected With Subclinical Becker's Muscular Dystrophy
Authors: P. Melacini, M. Fanin, G.A. Danieli, C. Villanova, F. Martinello, M. Miorin, M.P. Freda, M. Miorelli, M.L. Mostacciuolo, G. Fasoli, C. Angelini, S. Dalla Volta
Journal: Circulation (1996)

Several cases of Becker's muscular dystrophy (BMD) have been reported, which showed mild or subclinical skeletal muscle involvement with an overt dilated cardiomyopathy. Here, for the first time, a group of 28 patients with BMD who had a subclinical or benign myopathy have been studied through a thorough cardiological assessment.Each patient underwent ECG and echocardiographic examinations. Molecular analyses of the dystrophin gene and protein were performed. An unexpectedly high incidence of myocardial involvement was observed among patients affected with subclinical (72%) or benign (60%) BMD. The cardiac involvement appears to develop early from the right ventricle. Both the increase in left ventricular end-diastolic volume and the reduction in the ejection fraction appeared to be age related. Severe left ventricular dilation with reduced ejection fraction, which could be complicated by life-threatening arrhythmias, may occur. Contrary to previous reports, which indicated the involvement of 5'-end mutations in cardiomyopathies as a result of dystrophin gene alterations, this study shows that despite the apparent concentration of deletions in two regions (5'-end and exons 47 through 49), no general conclusions can be drawn regarding the involvement of specific gene mutations in the development of cardiomyopathy.Cardiomyopathy is the main clinical feature and complication in patients affected by subclinical or mild BMD. The cardiac manifestation is characterized by early right ventricular involvement and is later associated with left ventricular impairment. In mild BMD, myocardial damage may develop because the patients, who are unaware of a possible cardiac involvement, are still able to perform strenuous muscle exercise and, through pressure or volume overload, may induce mechanical stress, which is harmful for dystrophin-deficient myocardial cells.
Reply to Giuseppe Simone, Rocco Papalia and Michele Gallucci's Letter to the Editor re: Maurizio A. Brausi, Mirko Gavioli, Giuseppe De Luca et al. Retroperitoneal Lymph Node Dissection (RPLD) in Conjunction with Nephroureterectomy in the Treatment of Infiltrative Transitional Cell Carcinoma (TCC) of the Upper Urinary Tract: Impact on Survival. Eur Urol 2007;52:1414–20
Authors: Maurizio A. Brausi
Journal: European Urology (2008)
Lessons and legacies of war
Authors: F. Godlee
Journal: BMJ (2010)

Debate about the care of the UK’s veterans had for most of us been comfortably relegated to the week or two before poppy day. But it’s now back on the agenda as more and more young men and women return from Afghanistan after surviving what before would have been fatal injuries. What does a civilised society owe those who have risked life and limb in its service? Should they get priority over others for health and social care?

Julian Sheather says this is a political judgment (doi:10.1136/bmj.c642). And our politicians have already decided that veterans should have …
Senior doctor was present in 87% of anaesthesia cases in 2013
Authors: H. Mooney
Journal: BMJ (2014)

Anaesthesia is a predominantly consultant led service, with senior doctors present for 87% of all anaesthetics and 75% of the time when anaesthetic is given out of hours, a study has found.1

The findings of a survey by the Royal College of Anaesthetists and the Association of Anaesthetists of Great Britain and Ireland showed that anaesthetists were responsible for the care of more than 3.5 million patients a year—meaning that, in a given year, one person in 20 requires an anaesthetic.

The study also showed …
BMA Annual Representative Meeting: Tackle the government over job cuts, doctors tell BMA
Authors: Zosia Kmietowicz
Journal: BMJ (2006)

Doctors have called on the BMA to “vigorously” challenge the government over the thousands of jobs cuts being proposed in hospitals in England because of the financial crisis in the NHS.

Speaking at the BMA's annual representative meeting in Belfast, Anthea Mowat, an associate specialist anaesthetist at the Pilgrim Hospital in Boston, Lincolnshire, who put forward the motion, delivered a long list of proposed job cuts and redundancies in the NHS, some of which would be compulsory.

“In the east, Norfolk and Norwich [University …
Familial Behcet's syndrome
Authors: S.K. GOOLAMALI, J.S. COMAISH, F. HASSANYEH†, A. STEPHENS
Journal: British Journal of Dermatology (1976)

Behçet's syndrome is reported in a family of which four generations have so far been affected. The index patient also exhibited an unusual schizo-affective disorder. The histocompatibility antigen haplotype 1-17 was common to four with the disease. Genetic transmission may be responsible for the familial nature of the syndrome and the associated schizophrenia.
Chronic intestinal pseudo-obstruction due to lymphocytic leiomyositis: is there a place for immunomodulatory therapy?
Authors: E Oton
Journal: Gut (2005)

There is a rare cause of chronic intestinal pseudo-obstruction (CIPO) characterised by a lymphocytic infiltrate in the muscle of the intestine, which is called idiopathic lymphocytic leiomyositis. Few cases have been reported and prognosis is very poor. We present a case with a comparatively benign evolution, showing good response to immunosuppressive therapy.

The patient was a healthy 16 year old female who presented with a crisis of postprandial bloating followed by diarrhoea and vomiting. During the following months she lost 10 kg in weight and any attempt at oral feeding resulted in severe abdominal distension and vomiting. Therefore, total parenteral nutrition was finally prescribed. Plain abdominal film and small bowel follow through indicated huge dilatation of the small intestine with air fluid levels. Gastroscopy and colonoscopy were normal, as were mucosal biopsies.

Human immunodeficiency virus, hepatitis …
STALing B cell responses with CD22
Authors: Craig P. Chappell, Edward A. Clark
Journal: Journal of Clinical Investigation (2013)

Suppressing unwanted humoral immune responses without compromising the host’s ability to respond to foreign pathogens is a primary goal for therapies aimed at ameliorating harmful autoantibody production. Global suppression of the immune system via lymphocyte depletion and/or immunosuppressive drugs can have off-target effects, a limitation to conventional therapies. In this issue of the JCI, Macauley and colleagues utilize a novel platform to inhibit antigen-specific antibody production that preserves the immune system’s ability to respond to unrelated antigens.
Prothrombin Levels and Fatality Rates in Acute Myocardial Infarction
Authors: Lawrence E. Meltzer, Florentino Palmon, Madelyn Ferrigan, Jean Pekover, Herbert Sauer, J. Roderick Kitchell
Journal: JAMA (1964)

The records of 761 patients with acute myocardial infarction were reviewed to assess the value of optimum anticoagulant therapy and specifically to ascertain the relationship between levels of prothrombin control and fatalities. Results showed that oral anticoagulant therapy was associated with a significantly lower fatality rate than was no treatment; however, there was no relationship between levels of therapy and fatalities. Patients maintained at levels of 10% to 25% of normal prothrombin activity had the same incidence of thromboembolism and death as did those with poorer control and no advantage could be found for optimum therapy as it is now defined. Patients treated solely with heparin throughout hospitalization were considered separately. In this group the incidence of thromboembolism and death was high, resembling the rates obtained without anticoagulation and creating suspicion that heparin is not valuable in acute infarctions.
P-Consciousness presentation/A-Consciousness representation
Authors: Denise Gamble
Journal: Behavioral and Brain Sciences (1997)

P-Consciousness (P) is to be understood in terms of an immediate fluctuating continuum that is a presentation of raw experiential matter against which A-consciousness (A) acts to objectify, impose form or make determinate “thinkable” contents. A representationalises P but P is not itself representational, at least in terms of some concepts of “representation.” Block's arguments fall short of establishing that P is representational and, given the sort of cognitive science assumptions he is working with, he is unable to account for the aspect of phenomenal content that he thinks goes beyond “representational” content. BBS discussion reveals the need for greater analysis and justification for a representationalist thesis of P.
Modern worries, new technology, and medicine
Authors: K. J Petrie
Journal: BMJ (2002)

Over recent years there has been a steady and important change in the public's perception of the relation between aspects of modern life and health. Now, at the beginning of the 21st century, people's suspicion of modernity has increased to such an extent that it has undermined their view of their own health, increased their worries about environmental causes of poor health, and fostered a migration to complementary medicine. Concerns about the safety of mobile phones, environmental pollution, vaccines, bovine spongiform encephalopathy, genetically modified food, and food in general have led to a heightened awareness of the effect of environmental changes on health. We believe that these concerns about technological change, which have been largely unrecognised by researchers, have important implications for the way patients interact with health services.

This change in public concerns has obvious and more subtle effects. Despite considerable recent research and official inquiries into new technologies such as mobile phones and genetically modified food, public suspicion remains high. In clinical settings patients are reluctant to start medication or to continue it for an extended period for …
The significant of clinico-pathologic prognostic factors in malignant mixed mullerian uterine cancers
Authors: D. S. Kapp, D. Teoh, J. Y. Shin, K. Osann, C. B. Powell, L. Chen, J. K. Chan
Journal: Journal of Clinical Oncology (2008)

5584 Background: To evaluate the prognostic factors responsible for survival of women diagnosed with malignant mixed mullerian tumors (MMMT) of uterus. Methods: Demographic, pathologic, treatment, and survival information were obtained from the Surveillance, Epidemiology and End Results Program between 1988 and 2001. Data were analyzed using Kaplan-Meier and Cox proportional hazards regression methods. Results: Of 3,108 patients with MMMT, the median age was 70 years (range: 19–97). The majority (71.5%) were White, 17.0% African American, 6.3% Hispanic, and 4.5% were Asian. Stage I, II, III, and IV disease was diagnosed in 46.7%, 10.1%, 15.4%, and 27.8% of patients, respectively. Lymphadenectomy was performed in 55.9% of patients, and nodal metastases were found in 12.3%. Overall five-year disease-specific survival was 52.1%; including 68.2%, 51.6%, 40.7%, and 24.8% in stage I, II, III, and IV disease, respectively (p<0.001). Women with grade 1, 2, and 3 disease had survivals of 75.2%, 62.6%, and 47.0%, respectively (p<0.001). Nodal metastases portended for a worsened outcome (36% vs. 64.5%; p<0.001). Of the subgroup of women <50 years with stage I-II disease, oophorectomy did not influence survival (86.1% vs. 92.0%; p=0.691). In multivariate analysis, age, race, stage, lymphadenectomy, and radiation were independent prognostic factors for survival. Conclusions: Age, race, stage, grade, lymphadenectomy, and adjuvant radiation are important prognostic factors for survival. Ovarian-sparing procedures may be considered in younger patients with early-stage disease. No significant financial relationships to disclose.
ALLERGIC VASCULITIS CLINICAL AND HISTOLOGICAL FEATURES AND INCIDENCE OF RENAL INVOLVEMENT
Authors: COLIN RAMSAY, LIONEL FRY
Journal: British Journal of Dermatology (1969)

Journal Article ALLERGIC VASCULITIS CLINICAL AND HISTOLOGICAL FEATURES AND INCIDENCE OF RENAL INVOLVEMENT Get access COLIN RAMSAY, COLIN RAMSAY Skin Department. The London Hospital, E.1 Search for other works by this author on: Oxford Academic Google Scholar LIONEL FRY LIONEL FRY Skin Department. The London Hospital, E.1 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 81, Issue 2, 1 February 1969, Pages 96–102, https://doi.org/10.1111/j.1365-2133.1969.tb15987.x Published: 01 February 1969 Article history Accepted: 17 May 1968 Published: 01 February 1969
Broadening the Growth Hormone Insensitivity Syndrome
Authors: Ron G. Rosenfeld
Journal: New England Journal of Medicine (1995)

The development of recombinant-DNA–derived human growth hormone (GH) has made it much easier to treat patients with GH deficiency.1 Unfortunately, establishing a firm diagnosis of this deficiency is frequently difficult, even if detailed records of growth are available and many biochemical tests are performed.2 Although the difficulties can be attributed at least in part to the pulsatile secretion of GH and the vagaries of GH assays, they also reflect the complex relation between GH and the insulin-like growth factor (IGF) axis. To be biologically active, GH must bind to a transmembrane receptor, the receptor must form a dimer, and an . . .
The Lymphatic Spread of Osteosarcoma Shown by Tc-99m-MDP Scintigraphy
Authors: SYDNEY HEYMAN
Journal: Clinical Nuclear Medicine (1980)

Osteosarcoma usually spreads via the blood stream, resulting in pulmonary and skeletal metastases. The value of bone imaging in the management of these patients is widely accepted. Less commonly, the disease spreads via the lymphatics. Such a case is reported to show that bone imaging will detect progressive involvement of the lymph nodes.
The Effect of Cycle Length on the Time of Occurrence of the First Heart Sound and the Opening Snap in Mitral Stenosis
Authors: ADDISON L. MESSER, TIMOTHY B. COUNIHAN, MAURICE B. RAPPAPORT, HOWARD B. SPRAGUE
Journal: Circulation (1951)

Phonocardiography is often more valuable than electrocardiography in timing mechanical events in the cardiac cycle. This study shows that the opening and closing of the mitral valve are related to the length of the previous heart cycle as demonstrated by the variations occuring in auricular fibrillation. These variations in valve action are controlled by the pressure gradient between left auricle and ventricle.
Patients' understanding of risk
Authors: H. Thornton
Journal: BMJ (2003)

Who would disagree that understanding risks in order to trade them off against potential benefits is a prerequisite for citizens or patients who need to make health decisions? But rational consideration of risk, even if graphically explained1 and understood, is neither straightforward nor sufficient. Rationality is not the only component in decision making.

Apparently irrational influences and considerations exert strong pressures. Individuals' perceptions of risk, and attitudes to it, may lead them to choices that seem irrational to the health professional. Perceptions are built up over time, informed by personal experiences and social networks, and shaped by behavioural norms and media reporting. Fear of a disease, trust in technology, and the desire to take responsibility for health also contribute to decisions people make.2

Research shows that avoidance of regret (that an intervention was freely available but was not taken up), a perceived right to access, and pursuit of equitability are reasons given by men for accepting and recommending …
Signification psychologique de l’acte medical
Authors: C. Koupernik
Journal: Psychotherapy and Psychosomatics (1972)

The Word 'clinical examination' has a different meaning in psychiatry; this does not mean that a classical clinical examination is useless. Not only can it lead to an unexpected diagnosis of a physical illness presenting a psychiatric disturbance; it also gives clues to the phenomenology of the sick patient. Even the reaction of the examination of the deep reflexes provides information about the psychological attitude of the patient. Finally, less sophisticated patients would not understand why a doctor does not examine them.
Linear focal elastosis.
Authors: D. Ramlogan, B.B. Tan, M. Garrido
Journal: British Journal of Dermatology (2001)

Journal Article Linear focal elastosis Get access D. Ramlogan, D. Ramlogan Department of Dermatology, Central Out‐Patients, North Staffordshire Hospital, Stoke‐on‐Trent ST4 7PA, U.K. Search for other works by this author on: Oxford Academic Google Scholar B.B. Tan, B.B. Tan Department of Dermatology, Central Out‐Patients, North Staffordshire Hospital, Stoke‐on‐Trent ST4 7PA, U.K. Search for other works by this author on: Oxford Academic Google Scholar M. Garrido M. Garrido Department of Dermatology, Central Out‐Patients, North Staffordshire Hospital, Stoke‐on‐Trent ST4 7PA, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 145, Issue 1, 1 July 2001, Pages 188–190, https://doi.org/10.1046/j.1365-2133.2001.04319.x Published: 01 July 2001
Correction of mandibular deficiency by inverted-L osteotomy of ramus and iliac crest bone grafting
Authors: Song-Song Zhu, Ge Feng, Ji-Hua Li, En Luo, Jing Hu
Journal: International Journal of Oral Science (2012)

This study was to describe the use of inverted-L osteotomy of ramus and iliac bone graft for the management of mandibular deficiency in adult patients. From 2008 to 2010, 11 patients (aged 19 to 29 years) with mandibular deficiency underwent intraoral or extraoral inverted-L osteotomy of ramus and iliac crest bone grafting. Data were collected from the patients' records, photographs and radiographs. The height and width of the ramus were successfully expanded by inverted-L osteotomy and iliac crest bone grafting with minimal complications in all patients, resulting in significant improvement in occlusion and facial appearance. Our early results showed that the inverted-L osteotomy of ramus and iliac crest bone grafting is safe and effective, and should be considered as a good alternative for the patients with mandibular deficiency.