Protease Inhibitors Do Not Interfere with Prohormone Processing
Authors: Ann Danoff, Wai Lam W. Ling
Journal: Annals of Internal Medicine (2000)

Letters15 February 2000Protease Inhibitors Do Not Interfere with Prohormone ProcessingAnn Danoff, MD and Wai Lam W. Ling, PhDAnn Danoff, MDAlbert Einstein College of Medicine; Bronx, NY 10457 (Danoff)Albert Einstein College of Medicine; Bronx, NY 10457 (Ling)Search for more papers by this author and Wai Lam W. Ling, PhDAlbert Einstein College of Medicine; Bronx, NY 10457 (Danoff)Albert Einstein College of Medicine; Bronx, NY 10457 (Ling)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-4-200002150-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Introduction of protease inhibitor therapy has resulted in dramatic improvement in the survival of HIV-infected patients. Coincident with this benefit, a variety of metabolic derangements have been described, including HAL (HIV/highly active antiretroviral-associated lipodystrophy), hyperlipidemia, and abnormalities of glucose metabolism.Several explanations for these metabolic abnormalities have been proposed. Although the Cushing syndrome has been excluded (1), direct activation of the glucocorticoid receptor might explain the apparent glucocorticoid excess occurring in the absence of measurable hypercortisolism. Gene products related to HIV (2) and cytokines are being investigated as possible candidates for such glucocorticoid receptor activation. An additional ...References1. Lo J, Mulligan K, Tai V, Algren H, Schambelan M. “Buffalo hump” in men with HIV-1 infection. Lancet. 1998;351:867-70. CrossrefMedlineGoogle Scholar2. Kino T, Gragerov A, Kopp JB, Stauber RH, Pavlakis GN, Chrousos GP. The HIV-1 virion-associated protein vpr is a coactivator of the human glucocorticoid receptor. J Exp Med. 1999;189:51-62. CrossrefMedlineGoogle Scholar3. Carr A, Samaras K, Chisholm DJ, Cooper DA. Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlididaemia, and insulin resistance. Lancet. 1998;351:1881-3. CrossrefMedlineGoogle Scholar4. Goldberg B, Strickler RB. HIV protease and the pathogenesis of AIDS. Res Virol. 1996;147:375-9. CrossrefMedlineGoogle Scholar5. Visnegarwala F, Krause KL, Musher DM. Severe diabetes associated with protease inhibitor therapy [Letter]. Ann Intern Med. 1997;127:947. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Albert Einstein College of Medicine; Bronx, NY 10457 (Danoff)Albert Einstein College of Medicine; Bronx, NY 10457 (Ling) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoProtease Inhibitors and Prohormone Processing Raphael B. Stricker and Billi Goldberg Protease Inhibitors and Prohormone Processing Ann Danoff and Wai Lam W. Ling HIV-1 Protease Inhibitors May Interfere with the Ubiquitous Intracellular Proteases Fehmida Visnegarwala , Daniel M. Musher , and A.C. White Jr. Metrics Cited ByHIV Infection and DiabetesHIV Infection and DiabetesAlteration in Pancreatic Islet Function in Human Immunodeficiency VirusHIV Infection and DiabetesImpaired proinsulin secretion before and during oral glucose stimulation in HIV-infected patients who display fat redistributionHyperproinsulinaemia in normoglycaemic lipodystrophic HIV-infected patientsOral Glucose Tolerance and Insulin Sensitivity Are Unaffected by HIV Infection or Antiretroviral Therapy in Overweight WomenMechanisms for the Deterioration in Glucose Tolerance Associated With HIV Protease Inhibitor RegimensLipodystrophy, Insulin Resistance, Diabetes Mellitus, Dyslipidemia, and Cardiovascular Disease in Human Immunodeficiency Virus InfectionHIV-1 Protease Inhibitors May Interfere with the Ubiquitous Intracellular ProteasesFehmida Visnegarwala, MD, Daniel M. Musher, MD, and A.C. White Jr., MDProtease Inhibitors and Prohormone ProcessingRaphael B. Stricker, MD and Billi Goldberg, MPALipodystrophy Syndrome in HIV Infection 15 February 2000Volume 132, Issue 4Page: 330KeywordsCellsEnzymesHyperglycemiaHyperlipidemiaLipodystrophyProhormonesProtease inhibitor therapyProtease inhibitorsProteinsSomatostatin Issue Published: 15 February 2000 CopyrightCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...