IDIOSYNCRATIC FEBRILE REACTIONS TO THIOURACIL: CLINICAL CHARACTERISTICS AND POSSIBLE PHARMACOLOGIC SIGNIFICANCE
Authors: J W McARTHUR, R W RAWSON, J H MEANS
Journal: Annals of Internal Medicine (1945)

Article1 December 1945IDIOSYNCRATIC FEBRILE REACTIONS TO THIOURACIL: CLINICAL CHARACTERISTICS AND POSSIBLE PHARMACOLOGIC SIGNIFICANCEJANET W. MCARTHUR, M.D., RULON W. RAWSON, M.D., J. H. MEANS, M.D., F.A.C.P.JANET W. MCARTHUR, M.D., RULON W. RAWSON, M.D., J. H. MEANS, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-6-915 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThiouracil has been employed in the preoperative preparation of 104 patients suffering from thyrotoxicosis at the Massachusetts General Hospital between April 1943 and April 1945. Toxic reactions (applying the term in the most inclusive sense) have occurred in 15 instances. In five cases, fever has been the most conspicuous feature of the reaction. Case reports of three† of these patients are presented, together with speculations as to the fundamental significance of the idiosyncratic response.CASE REPORTSCase 1. E. H., a 40-year-old white married housewife, was admitted on April 8, 1944, complaining of weakness, easy fatigability, nervousness and a sense...Bibliography1. ASTWOOD EB: Medical treatment of hyperthyroidism, Bull. New England Med. Center, 1944, vi, 1. Google Scholar2. WILLIAMSCLUTE RHHM: Thiouracil for thyrotoxicosis, Jr. Am. Med. Assoc., 1945, cxxviii, 65. CrossrefGoogle Scholar3. GABRILOVEKERT JLMF: Sensitivity to thiouracil, Jr. Am. Med. Assoc., 1944, cxxiv, 504. CrossrefGoogle Scholar4. GARGILLLESSES SLMF: Toxic reactions to thiouracil, Jr. Am. Med. Assoc., 1945, cxxvii, 890. CrossrefGoogle Scholar5. BARTELS EC: Use of thiouracil in the preoperative preparation of patients with severe hyperthyroidism, Ann. Int. Med., 1945, xxii, 365. Google Scholar6. 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Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFATAL THYROID CRISIS COMPLICATING TOXIC GRANULOPENIA DURING THIOURACIL THERAPYClinical Use of Thiouracil 1 December 1945Volume 23, Issue 6Page: 915-923KeywordsAnxietyDrugsFeversHospitalsInflammationThyroid ePublished: 1 December 2008 Issue Published: 1 December 1945 Copyright & PermissionsCopyright, 1945, by The American College of PhysiciansPDF downloadLoading ...