tbuckley/cabot-search huggingface dataset:
ln-111 Granulocyte Response to Intervening Surgery Evidence of Sustained in Vivo Viability
Authors: DONALD S. SCHAUWECKE, BRUCE H. MOCK, ROBERT W. BURT, HENRY N. WELLMAN
Journal: Clinical Nuclear Medicine (1984)

A patient with chronic osteomyelitis had surgery performed between the early and delayed images of an ln-111 granulocyte scan. The early images showed no uptake, while the delayed images demonstrated marked soft tissue uptake, which was felt to be secondary to the inflammation of the intervening surgery. It was concluded that granulocytes, when labeled with ln-111, remain viable and can respond to inflammation that occurs after their injection.
Management of Simple Nodular Goiter: Current Status and Future Perspectives
Authors: Laszlo Hegedüs, Steen J. Bonnema, Finn N. Bennedbæk
Journal: Endocrine Reviews (2003)

The simple nodular goiter, the etiology of which is multifactorial, encompasses the spectrum from the incidental asymptomatic small solitary nodule to the large intrathoracic goiter, causing pressure symptoms as well as cosmetic complaints. Its management is still the cause of considerable controversy. The mainstay in the diagnostic evaluation is related to functional and morphological characterization with serum TSH and (some kind of) imaging. Because malignancy is just as common in patients with a multinodular goiter as patients with a solitary nodule, we support the increasing use of fine-needle aspiration biopsy (cytology). Most patients need no treatment after malignancy is ruled out. In case of cosmetic or pressure symptoms, the choice in multinodular goiter stands between surgery, which is still the first choice, and radioiodine if uptake is adequate. In addition to surgery, the solitary nodule, whether hot or cold, can be treated with percutaneous ethanol injection therapy. If hot, radioiodine is the therapy of choice. Randomized studies are scarce, and the side effects of nonsurgical therapy are coming into focus. Therefore, the use of the optimum option in the individual patient cannot at present be based on evidence. However, we are of the view that levothyroxine, although widely used, should no longer be recommended routinely for this condition. Within a few years, the introduction of recombinant human TSH and laser therapy may profoundly alter the nonsurgical treatment of simple nodular goiter.
THE EXAMINATION OF REGISTRANTS
Authors: M. L. HARRIS
Journal: JAMA (1918)

When the first draft started, it was entirely a new experience to the people of this country. The rules and regulations were so drawn as to place the carrying out of the provisions of the act in the hands of the people; in fact, the act itself forbade any one connected with the military establishment to have anything to do with the execution of the draft. The personnel of the boards, local and district, was made up of civilians, both lay and professional, none of whom had had any experience in the selection of men for the Army. Practically all of the members of the boards labored under the disadvantage of having no opportunity to acquaint themselves with the work to be done until they were appointed to the positions and ordered to proceed at once with the draft. It is no wonder, then, that things did not go at
Impact of Early Intervention on Psychopathology, Crime, and Well-Being at Age 25
Authors: Kenneth A. Dodge, Karen L. Bierman, John D. Coie, Mark T. Greenberg, John E. Lochman, Robert J. McMahon, Ellen E. Pinderhughes
Journal: American Journal of Psychiatry (2014)

Objective: This randomized controlled trial tested the efficacy of early intervention to prevent adult psychopathology and improve well-being in early-starting conduct-problem children. Method: Kindergarteners (N=9,594) in three cohorts (1991–1993) at 55 schools in four communities were screened for conduct problems, yielding 979 early starters. A total of 891 (91%) consented (51% African American, 47% European American; 69% boys). Children were randomly assigned by school cluster to a 10-year intervention or control. The intervention goal was to develop social competencies in children that would carry them throughout life, through social skills training, parent behavior-management training with home visiting, peer coaching, reading tutoring, and classroom social-emotional curricula. Manualization and supervision ensured program fidelity. Ninety-eight percent participated during grade 1, and 80% continued through grade 10. At age 25, arrest records were reviewed (N=817, 92%), and condition-blinded adults psychiatrically interviewed participants (N=702; 81% of living participants) and a peer (N=535) knowledgeable about the participant. Results: Intent-to-treat logistic regression analyses indicated that 69% of participants in the control arm displayed at least one externalizing, internalizing, or substance abuse psychiatric problem (based on self- or peer interview) at age 25, in contrast with 59% of those assigned to intervention (odds ratio=0.59, CI=0.43–0.81; number needed to treat=8). This pattern also held for self-interviews, peer interviews, scores using an “and” rule for self- and peer reports, and separate tests for externalizing problems, internalizing problems, and substance abuse problems, as well as for each of three cohorts, four sites, male participants, female participants, African Americans, European Americans, moderate-risk, and high-risk subgroups. Intervention participants also received lower severity-weighted violent (standardized estimate=−0.37) and drug (standardized estimate=−0.43) crime conviction scores, lower risky sexual behavior scores (standardized estimate=−0.24), and higher well-being scores (standardized estimate=0.19). Conclusions: This study provides evidence for the efficacy of early intervention in preventing adult psychopathology among high-risk early-starting conduct-problem children.
Respiratory Physiology: People and Ideas
Authors: David W. Cugell
Journal: JAMA (1997)

The neophyte, at the onset of a lengthy training program in science and, more specifically, respiratory physiology, begins with attempts to grasp basic concepts—blood gas transport, liquid and solute exchange, the mechanical properties of the lung and the role of surface tension, pulmonary chemoreceptors and reflexes—to name just a few. There is little time and, usually, scant interest in how the concepts evolved or the personalities and circumstances of those responsible for the complex topics one is struggling to master. Although I am neither a novice nor an expert on education, it seems clear that one can acquire an understanding of current concepts a bit faster, and with considerably less pain, with a historical perspective in addition to the latest www.xxx.edu download. Therein is the true worth of this interesting book. As the title says, it presents the ideas of noteworthy individuals and the use of those ideas by others
IL-18-based combinatorial adjuvants promote the NK-DC-mediated production of the CCR7 ligand CCL19 in lymph nodes from cancer patients
Authors: Jeffrey L Wong, Ravikumar Muthuswamy, David L Bartlett, Pawel Kalinski
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Effective accumulation and interaction of mature dendritic cells (DCs) and naïve T cells within lymph nodes (LNs), driven by the CCR7-CCL19/CCL21 axis, are critical for the induction of adaptive T cell immunity. Human natural killer (NK) cells activated by IL-18 exhibit unique '
Human Granulocytic Ehrlichiosis: A Case Series from a Medical Center in New York State
Authors: Maria E. Aguero-Rosenfeld
Journal: Annals of Internal Medicine (1996)

Background: Human granulocytic ehrlichiosis (HGE) is a newly described illness with few reports in the literature. Objective: To describe the clinical and laboratory features of HGE. Design: Case series. Setting: Tertiary care facility in New York State. Patients: 18 adult patients with HGE. Measurements: Epidemiologic, clinical, and laboratory features; treatment; and outcome of patients with HGE. Results: Patients presented with such symptoms as fever (94%) and myalgia or arthralgia (78%). Thirteen patients (71%) recalled being bitten by a tick before onset of symptoms. Leukopenia or thrombocytopenia was seen in 82% of patients, and abnormal liver enzyme levels were seen in 81%. Results of polymerase chain reaction were positive in 9 of 12 patients (75%); morulae were seen in 3 of 12 patients (25%); and the agent that causes HGE was cultured from 2 patients. All but one patient (94%) developed antibodies to Ehrlichia equi. Five patients (28%) were briefly hospitalized, and none died. All patients were successfully treated with doxycycline. Conclusions: The illness associated with HGE in these patients from the northeastern United States was more mild than that originally described in reports of HGE in the midwestern United States.
Heart disease framework aims to cut deaths in England
Authors: S. Mayor
Journal: BMJ (2000)

A radical and far reaching programme designed to transform the prevention diagnosis, and treatment of coronary heart disease in England has been announced, with the launch earlier this week of the long awaited national service framework for coronary heart disease.

The framework sets out a 10 year programme designed to achieve the government target of cutting coronary heart disease and stroke by 40% by 2010. It sets 12 standards for the prevention, diagnosis, and treatment of coronary heart disease; describes service models; and explains how the standards can be delivered and how progress will be monitored, with milestones and goals.

These standards include general measures (such as the requirement that the NHS and partner agencies should develop, implement, and monitor policies that reduce the prevalence of coronary risk factors in the population) as well as specific measures (such as the recommendation that people with symptoms of a possible heart attack should receive help from an …
Excision beyond the “normal” arterial wall with directional coronary atherectomy — Acute and long-term outcome
Authors: Nicoletta B. de Cesare, Jeffrey J. Popma, Patrick L. Whitlow, Cass A. Pinkerton, Dean J. Kereiakes, Kirk N. Garratt, Stephen G. Ellis
Journal: Journal of the American College of Cardiology (1991)
Parenchymal FE and collagen gene expression: An iron-clad association?
Authors: Scott L. Friedman
Journal: Hepatology (1995)

Background/Aims: Liver fibrosis and cirrhosis represent common pathological findings in humans with iron overload. This study was undertaken to assess whether in vivo targeting of iron to liver parenchymal or nonparenchymal cells would differently affect collagen gene activity. Methods: Rats were treated with an iron diet or intramuscular injections of iron dextran, and in situhybridization analyses on liver samples were performed. Results: These iron treatments determined parenchymal or reticuloendothelial cell iron overload, respectively. The typical distribution of iron into different liver cells was documented by histochemistry and confirmed by in situ hybridization analysis with a ferritin L complementary RNA probe. In iron-fed rats, in situ hybridization analysis identified a signal for collagen type I messenger RNA into nonparenchymal cells in zones I and II. In rats with nonparenchymal cell iron overload, no activation of collagen gene expression was detected into or near iron-laden nonparenchymal cells. These findings were also confirmed by quantitative Northern blot analysis. Conclusions: The results of this study indicate that, regardless of the total hepatic iron burden, selective localization of iron into liver cells (i.e., parenchymal cells) is required for the activation of collagen gene during longterm iron overload in rodents.
Common variants at 6q22 and 17q21 are associated with intracranial volume
Authors: M Arfan Ikram, Myriam Fornage, Albert V Smith, Sudha Seshadri, Reinhold Schmidt, Stéphanie Debette, Henri A Vrooman, Sigurdur Sigurdsson, Stefan Ropele, H Rob Taal, Dennis O Mook-Kanamori, Laura H Coker, W T Longstreth, Wiro J Niessen, Anita L DeStefano, Alexa Beiser, Alex P Zijdenbos, Maksim Struchalin, Clifford R Jack, Fernando Rivadeneira, Andre G Uitterlinden, David S Knopman, Anna-Liisa Hartikainen, Craig E Pennell, Elisabeth Thiering, Eric A P Steegers, Hakon Hakonarson, Joachim Heinrich, Lyle J Palmer, Marjo-Riitta Jarvelin, Mark I McCarthy, Struan F A Grant, Beate St Pourcain, Nicholas J Timpson, George Davey Smith, Ulla Sovio, Mike A Nalls, Rhoda Au, Albert Hofman, Haukur Gudnason, Aad van der Lugt, Tamara B Harris, William M Meeks, Meike W Vernooij, Mark A van Buchem, Diane Catellier, Vincent W V Jaddoe, Vilmundur Gudnason, B Gwen Windham, Philip A Wolf, Cornelia M van Duijn, Thomas H Mosley, Helena Schmidt, Lenore J Launer, Monique M B Breteler, Charles DeCarli
Journal: Nature Genetics (2012)
397 LONG-TERM RESULTS OF RADIOFREQUENCY ABLATION (RFA) IN PATIENTS WITH CIRRHOSIS AND HCC ≤ 5 CM IN DIAMETER
Authors: G. Nkontchou, O. Seror, A. Mahamoudi, A. Mounir, N. Ganne Carrie, V. Grando Lemaire, E. Vicaut, J.C. Trinchet, M. Beaugrand
Journal: Journal of Hepatology (2008)
Benefits and Harms of Statin Therapy for Persons With Chronic Kidney Disease
Authors: Suetonia C. Palmer, Jonathan C. Craig, Sankar D. Navaneethan, Marcello Tonelli, Fabio Pellegrini, Giovanni F.M. Strippoli
Journal: Annals of Internal Medicine (2012)

Background: Statins have uncertain benefits in persons with chronic kidney disease (CKD) because individual trials may have insufficient power to determine whether treatment effects differ with severity of CKD. Purpose: To summarize the benefits and harms of statin therapy for adults with CKD and examine whether effects of statins vary by stage of kidney disease. Data Sources: Cochrane and EMBASE databases (inception to February 2012). Study Selection: Randomized trials comparing the effects of statins with placebo, no treatment, or another statin on mortality and cardiovascular outcomes. Data Extraction: Two independent reviewers extracted data and assessed risk of bias. Data Synthesis: Eighty trials comprising 51 099 participants compared statin with placebo or no treatment. Treatment effects varied with stage of CKD. Moderate- to high-quality evidence indicated that statins reduced all-cause mortality (relative risk [RR], 0.81 [95% CI, 0.74 to 0.88]), cardiovascular mortality (RR, 0.78 [CI, 0.68 to 0.89]), and cardiovascular events (RR, 0.76 [CI, 0.73 to 0.80]) in persons not receiving dialysis. Moderate- to high-quality evidence indicated that statins had little or no effect on all-cause mortality (RR, 0.96 [CI, 0.88 to 1.04]), cardiovascular mortality (RR, 0.94 [CI, 0.82 to 1.07]), or cardiovascular events (RR, 0.95 [CI, 0.87 to 1.03]) in persons receiving dialysis. Effects of statins in kidney transplant recipients were uncertain. Statins had little or no effect on cancer, myalgia, liver function, or withdrawal from treatment, although adverse events were evaluated systematically in fewer than half of the trials. Limitation: There was a reliance on post hoc subgroup data for earlier stages of CKD. Conclusion: Statins decrease mortality and cardiovascular events in persons with early stages of CKD, have little or no effect in persons receiving dialysis, and have uncertain effects in kidney transplant recipients. Primary Funding Source: None.
Surgery of the vertical muscles of the eye
Authors: William A. Mann
Journal: JAMA (1962)

When the first edition of this book, entitled<i>Surgery of the Oblique Muscles of the Eye</i>, appeared in 1951, it became generally regarded as the most authoritative text on a long-neglected aspect of ocular surgery. Prior to 20 years ago, operations on the lateral recti were commonly performed, but operative intervention for overaction or underaction of the vertical muscles, especially the obliques, was rare and many authorities regarded it as impractical. The author has played no small part in the recognition of the important place of the vertical muscles in satisfactory surgical correction of muscular anomalies of the eyes. In this new edition, greatly enlarged and extensively revised, he has added the superior and inferior rectus to his studies, hence the change in title to encompass all the vertical muscles. The typography is excellent, the text clearly written, and the 102 illustrations well done and understandable to both the experienced
Cryoglobulinaemic vasculitis as presenting manifestation of infective endocarditis
Authors: L La Civita
Journal: Annals of the Rheumatic Diseases (2002)

Seroimmunological alterations, including antibodies and/or cryoglobulins, are common in infective endocarditis (IE)1; however, specific autoimmune disorders, such as cryoglobulinaemic vasculitis (CV) associated with IE have seldom been described.2–5 CV is related to the vascular deposition of circulating immune complexes, mainly cryoglobulins, and complement5,6; in 70–90% of patients with CV a triggering role of hepatitis C virus (HCV) has been suggested.7,8 We report the case of two patients who showed a typical CV with severe neurological involvement as the presenting manifestation of underlying IE.

In November 1994 a 63 year old woman presented with fever, purpura, paraesthesias, and pseudoataxic gait. Her past clinical history was unremarkable except for a prosthetic implant of the left hip four years previously. Table 1 shows the main clinicoserological features. Repeated blood cultures were negative. Neurological examination showed abnormal tactile sensation in the arms and legs; mild ideomotor slowing down; shaky movements; and unsteady gait. An electrophysiological study recorded a moderate sensorimotor …
Mid-gastrointestinal Bleeding: Capsule Endoscopy and Push-and-pull Enteroscopy Give Rise to a New Medical Term
Authors: C. Ell, A. May
Journal: Endoscopy (2006)

Capsule endoscopy (CE) and push-and-pull enteroscopy (PPE) using the double-balloon technique have revolutionized imaging procedures in the field of small-bowel diagnosis. CE, which was introduced into clinical practice in 2001, made it possible for the first time to image intraluminal conditions in the entire small bowel with excellent quality [1] [2]. PPE, the prototype stage of which was first reported in 2001 by H. Yamamoto and by our own group in 2003, made it possible not only to inspect small-bowel diseases but also to carry out intraluminal treatment of them [3] [4].
Metastatic Calcification Difference of Uptake Between Tc-99m HMDP and Ga-67 Citrate
Authors: TSUNEO HIRANO, HIDENORI OTAKE, KAZUHIDE ICHIKAWA, YOSHIMICHI OHMORI, KAZUYOSHI KUNITOMO
Journal: Clinical Nuclear Medicine (1995)

Tc-99m HMDP bone scintigraphy clearly demonstrated metastatic calcification in a lung and stomach in a patient with renal failure and hypercalcemia. Ga-67 citrate scintigraphy showed increased lung activity, but failed to demonstrate the stomach. The difference in uptake between Ga-67 citrate and Tc-99m HMDP in the regions of metastatic calcification could suggest there is a different uptake mechanism at various sites of metastatic calcification.
A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma
Authors: J Adélaïde, C Pérot, V Gelsi-Boyer, C Pautas, A Murati, C Copie-Bergman, M Imbert, M Chaffanet, D Birnbaum, M-J Mozziconacci
Journal: Leukemia (2006)
Presentation is often pain free in elderly patients
Authors: O M P Jolobe
Journal: BMJ (1994)

<h3>Background</h3> The ability to maintain joint stability and motion control of the extremities is important in injury prevention and recovery. Quantitative measurement of proprioception, especially the upper extremity, is difficult and requires expensive equipment. <h3>Objective</h3> We investigated the reliability of a custom iPhone app to compile accelerometer data and calculate a path length of movement during 20 second trials. <h3>Design</h3> This study used a prospective test-retest design. Subjects completed three trials on each upper extremity (RA and LA) 48 hours apart (MWF). A convenience sample of subjects was used. <h3>Setting</h3> The study was conducted at a small liberal arts undergraduate institution. <h3>Patients (or Participants)</h3> Subjects were students associated with exercise science or athletic training programs. The activity level ranged from recreational athlete to NCAA Division II athletes. Twenty-three subjects started with 15 completing all upper extremity trials. Exclusion criterion was an upper extremity injury in the last month. <h3>Interventions (or Assessment of Risk Factors)</h3> An iPhone 6 app was developed to utilize accelerometer data in a Cartesian grid. Data was obtained at 20 Hz to calculate a path length of motion for each trial. Each subject stood, holding the iPhone in the palm of the hand directly in front of the shoulder with palm up, attempting to minimize motion for 20 seconds. <h3>Main Outcome Measurements</h3> Reliability measures were calculated between trials using the path length of motion in each trial. <h3>Results</h3> The mean path length for RA was 2669 with a standard error of 372, with LA being 2774 and 424. The intraclass correlation coefficient was 0.86 for the right arm and 0.74 for the left across three trials. <h3>Conclusions</h3> The accelerometer in an iPhone 6 is a moderately reliable instrument for assessing motion control stability in the upper extremity. We plan to add additional data filtering to the app.
Allergic alveolitis in a maltworker
Authors: H. F. V. Riddle, S. Channell, W. Blyth, D. M. Weir, M. Lloyd, W. M. G. Amos, I. W. B. Grant
Journal: Thorax (1968)

<h3>Introduction</h3> Post-stroke fatigue negatively influences short-term functional outcome in older stroke survivors. In young adults, in the midst of their active working and family life, this influence may even be more pronounced. However, there are only few studies on this topic in young patients with stroke. Therefore, we investigated the long-term prevalence of post-stroke fatigue in patients with a young transient ischaemic attack (TIA) or ischaemic stroke and its association with functional outcome. <h3>Methods</h3> This study is part of a large cohort study among 511 stroke survivors with a first-ever TIA or ischaemic stroke, aged 18–50 years. After a mean follow-up of 9.8 (SD 8.4) years, we assessed the presence of fatigue with the fatigue subscale of the Checklist Individual Strength questionnaire and functional outcome. Prevalence of fatigue between young patients with stroke and 147 stroke-free sex-matched and age-matched controls was compared. OR9s for poor functional outcome on modified Rankin Score (mRS&gt;2) and Instrumental Activities of Daily Living (IADL&lt;8) and cognitive performance were calculated using logistic regression analysis. <h3>Results</h3> Of the young patients with stroke, 41% experienced symptoms of fatigue, versus 18.4% in controls (p 0.0005). Fatigue was associated with a poor functional outcome, as assessed by the mRS (OR 4.0 (95% CI 1.6 to 9.6), IADL (OR 2.2 (95% CI 1.1 to 4.6), and impairment in speed of information processing (OR 2.2 (95% CI 1.3 to 3.9). <h3>Conclusions</h3> Fatigue was very common in young stroke survivors and was associated with a poor functional outcome, even after almost a decade of follow-up.
Bayer faces shake up after Lipobay withdrawn
Authors: A. Tuffs
Journal: BMJ (2001)

Two months after the withdrawal of cerivastatin (Lipobay) from the market because of associated deaths, the German manufacturer, Bayer, is still facing possible damaging consequences. In particular, it faces a collective legal claim by patients in the United States and is also having to restructure the firm.

In August Bayer decided to take cerivastatin off the market when several cases of deaths due to rhabdomyolysis came to light as a presumed consequence of high dose cerivastatin, especially in combination with another cholesterol lowering drug gemfibrozil (18 August, p 359).

There was a public …