tbuckley/cabot-search huggingface dataset:
Politicians must stop exploiting patients
Authors: L. Eaton
Journal: BMJ (2002)

Politicians and the media should stop using patients to score party political points. That was the message from the BMA chairman, Dr Ian Bogle, in his opening speech to this year's annual representative meeting, held in Harrogate this week, in which he described the NHS as having become “the Punch and Judy show of British politics.”

He cited the case of Rose Addis, the 94 year …
Hypertriglyceridemia Associated with Thrombocytopenia and Lipoprotein Lipase Deficiency
Authors: L. ROMICS
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 November 1981Hypertriglyceridemia Associated with Thrombocytopenia and Lipoprotein Lipase DeficiencyL. ROMICS, M.D.L. ROMICS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-5-660_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with great interest the brief report of Durrington and associates (1) on the joint occurrence of severe hypertriglyceridemia and pancytopenia.A 34-year-old woman followed by us for 9 years has thrombocytopenia, leukopenia, and, occasionally, anemia. Her mother has type V hyperlipoproteinemia. Of her father we know only that he took Clofibrate at one time, was obese, and died at age 56 from myocardial infarction; we had not examined him.The abdominal pains of the patient started at the age of 15 and have persisted with variable intensity since then. A low-fat diet considerably reduces her...References1. DURRINGTONMACIVERHOLDSWORTHGALTON PJGD. Severe hypertriglyceridemia associated with pancytopenia and lipoprotein lipase deficiency. Ann Intern Med. 1981;94:211-2. LinkGoogle Scholar2. BEAUMONTCARLSONCOOPERFEJFARFREDERICKSONSTRAUSS JLGZDT. Classification of hyperlipidemias and hyperlipoproteinemias. Bull WHO. 1970;43:891-915. MedlineGoogle Scholar3. BOBERG J. Quantitative determination of heparin released lipoprotein lipase activity in human plasma. Lipids. 1970;5:452-5. CrossrefMedlineGoogle Scholar4. BRECKENRIDGELITTLESTEINERCHOWPOAPST WJGAM. Hypertriglyceridemia associated with deficiency of apolipoprotein C-II. N Engl J Med. 1978;298:1265-73. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByLipoprotein lipase deficiency/type I hyperlipoproteinemia 1 November 1981Volume 95, Issue 5Page: 660-661KeywordsAbdominal painAnemiaDietLipasesLipoproteinsMyocardial infarctionOverweight Issue Published: 1 November 1981 PDF DownloadLoading ...
Topic: Committee Consultation to Prolong or Stop Extreme Care Measures
Authors: Ned H. Cassem
Journal: Psychotherapy and Psychosomatics (1975)

In response to increased public fear that life-saving efforts of the hospital might be pursued to the detriment rather than help of the patients, a committee was formed to study and advise about treatment of irreversibly ill patients. In a small number of cases uncertainty about prognosis and treatment generated considerable conflict, which was displaced or expressed as distorted facts, poor clinical judgments, irrational hostility toward treatment, and inadequate treatment. Methods for decreasing conflict in decisions to prolong or limit treatment include maximizing knowledge about treatment, increasing communication about treatment (even using in the ICU a treatment-classification system), and providing specialized committee consultation for the primary physician. The most intensive care is required by patient and family after reaching a decision to limit therapeutic measures.
Abstract 21298: Phospholemman Palmitoylation: a Novel Means of Sodium Pump Regulation
Authors: Lindsay B Tulloch, Michael J Shattock, William Fuller
Journal: Circulation (2010)

Phospholemman (PLM), the principal sarcolemmal substrate for protein kinases A and C (PKA and PKC) in the heart, is a key regulator of the cardiac sodium pump. We investigated post-translational mo...
Intensive Insulin Therapy in Critically Ill Patients
Authors: Greet Van den Berghe, Pieter Wouters, Frank Weekers, Charles Verwaest, Frans Bruyninckx, Miet Schetz, Dirk Vlasselaers, Patrick Ferdinande, Peter Lauwers, Roger Bouillon
Journal: New England Journal of Medicine (2001)

Hyperglycemia and insulin resistance are common in critically ill patients, even if they have not previously had diabetes. Whether the normalization of blood glucose levels with insulin therapy improves the prognosis for such patients is not known.
Measles Virus-Specific IgG in Cerebrospinal Fluid in Multiple Sclerosis
Authors: M. Haire, J. H. D. Millar, J. D. Merrett
Journal: BMJ (1974)

The prevalence of measles virus-specific IgG in cerebrospinal fluid (C.S.F.) of patients with multiple sclerosis (M.S.) has been compared with that in fluids from patients with other neurological diseases and from normal control subjects. The prevalence in the three groups was 58.1%, 24.1%, and 0% respectively. Fivefold concentration of the specimens increased the prevalence in the first two groups to 80.6% and 34.5% respectively, while measles IgG was not detected in any fluids of the normal control group, even after concentration.
Clearance Studies of Angiotensin II and [35S] Phenylthiocarbamyl-angiotensin II in the Sheep and Dog
Authors: E. C. Osborn, S. G. Hughes, A. T. Pirie, P. R. Willicombe, R. F. Mahler
Journal: Cardiovascular Research (1969)

Studies in the sheep and dog with angiotensin II, radioactive phenylthiocarbamy, and fluorescein-labelled angiotensin II suggest that saturation of the metabolic processes of uptake and destruction at "receptor sites" plays an unimportant role in the development of tachyphylaxis to angiotensin, and that it is independent of plasma angiotensinase activity.
How Justifiable Is Public Support of Sexually Transmitted Disease Clinical Services?
Authors: Willard Cates
Journal: JAMA (1986)

Recent concern about increasing budget deficits has led some policymakers, health planners, and clinicians to reconsider the issue of public support of sexually transmitted disease (STD) clinical services. Moreover, the expanded spectrum of sexually transmitted organisms—especially the specter of human T-cell lymphotropic virus type III—has placed heightened demands on already-limited resources. Arguments to limit public resources have generally contained five overlapping themes<sup>1</sup>: Disincentive to Prevention.—"Free" clinics encourage disease-prone behavior (such as nonuse of condoms) by removing the cost incentive. Promotion of Irresponsible Behavior.—"Free" clinics "foster" sexual irresponsibility; it is unfair to expect taxpayers to underwrite the sequelae of "irresponsible sex." Better Use of Funds.—"Free" STD clinics compete for limited public health resources, which would be better applied to more cost-effective preventive interventions. No Public Health Threat.—Sexually transmitted diseases pose no general threat to the public at large; the "truly innocent victims" are few in number and
Discussion, Ideas Abound in Migraine Research; Consensus Remains Elusive
Authors: Tim Kirn
Journal: JAMA (1987)

WHEN LEONARD LOVSHIN, MD, asked a fellow conferee at the 28th Annual Scientific Meeting of the American Association for the Study of Headache to support a point he was making about migraine, his friend quipped: "That's twice in 30 years we've agreed." The friend may have been only half joking. And Lovshin, director emeritus of the Department of Internal Medicine at the Cleveland Clinic Foundation, was lucky at that. Had he asked anyone else, that person very well might have disagreed. When it comes to migraine, there never has been much consensus among headache specialists. But recent research suggests that migraine, and headache in general, is even more of a mystery than had been thought, and many headache specialists are beginning to question even the basic tenets of migraine theory. In fact, disagreement over the whats, whys, and hows of migraine are so common that Donald Dalessio, MD, chair of
Lifeblood responds to criticisms in Welfare's personal view article
Authors: A. Stephens-Boal, S. Webster, K. Carter, I. M. Franklin, B. Gardner, S. Hart, B. J. Hunt, S. Noble, R. Offord
Journal: BMJ (2012)

Any belief that the charity Lifeblood is controlled by big pharma is a misconception.1 Lifeblood has always striven to be independent; around 58% of our income is from public donations. All funding from drug companies is ring fenced for educational or awareness projects.

In 2008 an article suggested that Lifeblood endorsed a new oral anticoagulant without Lifeblood’s knowledge and consent. Lifeblood reported Boehringer Ingelheim for breaching the …
Combined Insulin-Sulfonylurea Therapy in Treatment of NIDDM
Authors: Leif C Groop, Per-Henrik Groop, Svante Stenman
Journal: Diabetes Care (1990)

For the past few years, interest has focused on the combination of insulin and sulfonylurea in the search for effective treatments for non-insulin-dependent diabetes mellitus (NIDDM) patients who fail on oral hypoglycemic agents. Although several studies have demonstrated beneficial effects of such therapy in NIDDM patients, the average effect is small and is observed in only about half of the patients. However, there are several problems with most previous studies, including small sample size, selection of patients, and simultaneous use of several end points. First, residual β-cell function has been considered to be a prerequisite for a beneficial effect of combination therapy. Therefore, most studies have failed to demonstrate improved glycemic control after adding sulfonylurea to insulin therapy in patients with insulin-dependent diabetes mellitus. Inclusion of patients with impaired β-cell function will therefore attenuate the effect of combination therapy. Second, most studies have used glycemic control as an end point. Nevertheless, the insulin dose has been reduced by 20–30% to avoid hypoglycemia after adding sulfonylurea to insulin. Thus, the comparison has been made between treatments with a smaller insulin dose with sulfonylurea and a larger insulin dose without sulfonylurea. The patient most likely to benefit from combination therapy is slightly obese, has had NIDDM for a relatively short period, and has preserved β-cell function. In such a patient, combined insulin-sulfonylurea therapy predominantly stimulates basal insulin secretion, resulting in more effective suppression of hepatic glucose production and lower fasting plasma glucose. The side effects are few, most notably more frequent but mild hypoglycemic reactions.
Benzalkonium Chloride as a Source of Infection
Authors: Walter F. Malizia, Eugene J. Gangarosa, Alex F. Goley
Journal: New England Journal of Medicine (1960)

BENZALKONIUM chloride is widely used as a germicide in clinical medicine. When used correctly it is an agent of proved effectiveness, but its misuse can result in severe and even fatal infections.1 This study records 2 separate incidents at Walter Reed Army Hospital occurring approximately a year apart in which benzalkonium chloride¶ was incriminated as the source of contamination. In the first incident, 11 patients from the gastrointestinal and hematologic wards apparently acquired infections from solutions of benzalkonium chloride that were used for skin disinfection. The second incident occurred in the delivery room, but no known infections were recorded, mainly . . .
Rapid irreversible encephalopathy associated with anti‐D immune globulin treatment for idiopathic thrombocytopenic purpura
Authors: Kenneth Christopher, Clare Horkan, Ilie T. Barb, Christian Arbelaez, Travis A. Hodgdon, Paul C. Yodice
Journal: American Journal of Hematology (2004)

Abstract Intravenous Rho (D) immune globulin (IV RhIG, WinRho SDF) has been shown to be a safe treatment for idiopathic thrombocytopenic purpura (ITP). Common side effects of IV RhIG include mild hemolysis, febrile reaction, and headache. Significant hemolysis with renal impairment following IV RhIG has been reported. We report a case of irreversible encephalopathy 48 hr following an infusion of IV RhIG for treatment of ITP. Am. J. Hematol. 77:299–302, 2004. © 2004 Wiley‐Liss, Inc.
COCILLANA—THE BARK OF AN UNDETERMINED SPECIES OF GUAREA.NATURAL ORDER—MELIACEÆ; HABITAT, BOLIVIA. Read in the Section on Materia Medica and Pharmacy, at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: F. G. RYAN
Journal: JAMA (1894)

This remedy,which was first brought to the attention of the medical profession by Dr. H. H. Rusby of the New York College of Pharmacy, seems to be gaining much favor. The results of many clinical investigations indicate that this drug is destined to become one of great usefulness in the treatment of diseases of the respiratory organs. The following botanical description is taken from the "Pharmacology of Newer Materia Medica:" "This species was first described by Dr. N. L. Britton of Columbia College, under the name of<i>Sycocarpus Rusbyi</i>, on the supposition that it was a new genus belonging to the natural order<i>Anacardiaceæ</i>. On the subsequent acquisition of complete specimens, Dr. Britton at once recognized the true affinities of the plant as being with the genus<i>Guarea</i>, natural order<i>Meliaceæ</i>, and referred it with some doubt to the species<i>Guarea trichlioides</i>, (Linn.) While it is certainly a<i>Guarea</i>, there
There Is More to Life Than Death
Authors: Pamela Hartzband, Jerome Groopman
Journal: New England Journal of Medicine (2012)

Interview with Dr. Pamela Hartzband and Dr. Jerome Groopman on shared decision making and patient-centered care. (00:00)Download In classic medical decision analysis, when outcomes are uncertain and risk is involved, the "best" choice is the one with the "highest expected utility." The outcome usually measured is death, which is readily determined and quantified. But what of other key outcomes?
Patient Preference and Contraindications in Measuring Quality of Care: What Do Administrative Data Miss?
Authors: Joan J. Ryoo, Diana L. Ordin, Anna Liza M. Antonio, Sabine M. Oishi, Michael K. Gould, Steven M. Asch, Jennifer L. Malin
Journal: Journal of Clinical Oncology (2013)

Prior studies report that half of patients with lung cancer do not receive guideline-concordant care. With data from a national Veterans Health Administration (VHA) study on quality of care, we sought to determine what proportion of patients refused or had a contraindication to recommended lung cancer therapy.Through medical record abstraction, we evaluated adherence to six quality indicators addressing lung cancer-directed therapy for patients diagnosed within the VHA during 2007 and calculated the proportion of patients receiving, refusing, or having contraindications to recommended treatment.Mean age of the predominantly male population was 67.7 years (standard deviation, 9.4 years), and 15% were black. Adherence to quality indicators ranged from 81% for adjuvant chemotherapy to 98% for curative resection; however, many patients met quality indicator criteria without actually receiving recommended therapy by having a refusal (0% to 14%) or contraindication (1% to 30%) documented. Less than 1% of patients refused palliative chemotherapy. Black patients were more likely to refuse or bear a contraindication to surgery even when controlling for comorbidity; race was not associated with refusals or contraindications to other treatments.Refusals and contraindications are common and may account for previously demonstrated low rates of recommended lung cancer therapy performance at the VHA. Racial disparities in treatment may be explained, in part, by such factors. These results sound a cautionary note for quality measurement that depends on data that do not reflect patient preference or contraindications in conditions where such considerations are important.
The Protective Property of Equipotent Bronchodilating Doses of Inhaled KWD 2131 and Terbutaline against Allergen-Induced Bronchospasm
Authors: B. Hegardt, O. Löwhagen, N. Svedmyr, G. Granerus
Journal: Allergy (1982)

The anti-allergic capacity of nebulized KWD 2131 in inhibiting allergen-induced bronchospasm was compared with that of terbutaline in equipotent bronchodilating doses. It was a double-blind cross-over and randomized study also including placebo. Twelve symptom-free extrinsic asthmatics participated in the trial. Equipotent bronchodilating doses of the two β-receptor-agonists were established in a histamine challenge procedure before the start of the study. Allergen challenge was performed with double concentration steps every 10 min until a ≥20% decrease in FEV1 was achieved. Significanty (P<0.001) more allergen dose steps could be used after pretreatment with KWD 2131 and terbutaline than with placebo. No difference could be observed between the active compounds. The same allergen log dose gave a 20% decrease in FEV1 after pretreatment with KWD 2131 and terbutaline. The active compounds' protective properties did not differ at a lower degree of allergen challenge. The plasma histamine level was not significantly changed at any point of allergen challenge after pretreatment with either placebo or the active compounds. Therefore, plasma histamine determination was of no value for evaluating the inhibition of mediator release by these drugs. It is concluded that the anti-allergic property of KWD 2131 at allergen challenge does not give any further clinical value besides the brochodilating property.
Risk factors of acute renal failure after liver transplantation
Authors: J.B. Cabezuelo, P. Ramírez, A. Ríos, F. Acosta, D. Torres, T. Sansano, J.A. Pons, M. Bru, M. Montoya, F.S. Bueno, R. Robles, P. Parrilla
Journal: Kidney International (2006)
Parasympathetic control of cycle length dependence of endocardial ventricular repolarisation in the intact feline heart during steady state conditions
Authors: G. Malfatto, A. Zaza, P. J Schwartz
Journal: Cardiovascular Research (1993)

Journal Article Parasympathetic control of cycle length dependence of endocardial ventricular repolarisation in the intact feline heart during steady state conditions Get access Gabriella Malfatto, Gabriella Malfatto Universitá degli Studi di Milano, Via Francesco Sforza 35, 20122 Milan, Italy - Istituto di Clinica Medica II: G Malfatto; Dipartimento di Fisiologia e Biochimica Generali: A Zaza; Dipartimento di Medicina, Universitá degli Studi di Pavia, Italy: P J Schwartz. Correspondence to Dr Malfatto. Search for other works by this author on: Oxford Academic PubMed Google Scholar Antonio Zaza, Antonio Zaza Universitá degli Studi di Milano, Via Francesco Sforza 35, 20122 Milan, Italy - Istituto di Clinica Medica II: G Malfatto; Dipartimento di Fisiologia e Biochimica Generali: A Zaza; Dipartimento di Medicina, Universitá degli Studi di Pavia, Italy: P J Schwartz. Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter J Schwartz Peter J Schwartz Universitá degli Studi di Milano, Via Francesco Sforza 35, 20122 Milan, Italy - Istituto di Clinica Medica II: G Malfatto; Dipartimento di Fisiologia e Biochimica Generali: A Zaza; Dipartimento di Medicina, Universitá degli Studi di Pavia, Italy: P J Schwartz. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 5, May 1993, Pages 823–827, https://doi.org/10.1093/cvr/27.5.823 Published: 01 May 1993 Article history Received: 01 June 1992 Accepted: 22 October 1992 Published: 01 May 1993
Significance of Polypectomy in the Large Bowel - Endoscopy
Authors: P. Frühmorgen, W. Matek
Journal: Endoscopy (1983)

The precancerous and early stages of colorectal carcinoma are, in the vast majority of cases, known and pathologically unequivocally defined. The precancerous and early stages of colorectal carcinoma can be detected by routine diagnostic measures (colonoscopy) with an adequate degree of reliability. A curative treatment of precursor and early stages of colorectal carcinoma is possible. As a rule, the procedure used is endoscopic polypectomy. A lowering of the incidence rates and mortality figures of large-bowel carcinoma through the routine detection and thoroughgoing endoscopic treatment of precursors of colorectal carcinoma would appear possible. The conclusion follows logically from the established points 1 to 3. The significance of polypectomy in the large bowel, which today is carried out routinely using a standardized technique, is to be seen in the prevention and early detection of colorectal carcinomas.
Genetic alterations in carcinogenesis and chemoprevention.
Authors: M P Rosin
Journal: Environmental Health Perspectives (1993)

Laboratory and clinical studies suggest that genetic change is intrinsically involved in the development of cancer and that this change occurs in humans throughout carcinogenesis, in both early and late stages. Therefore, the quantification of the level of genetic change in human epithelial tissues may serve as a marker for cancer risk. The micronucleus test has been used to quantify the level of site-specific chromosomal breakage occurring in epithelial tissues of individuals at elevated risk for cancer. These studies include individuals exposed to carcinogens, patients who have chromosome-breakage syndromes, and individuals with premalignant lesions. As a counterpart to this approach, the assay has been used to study the suppression of this breakage with chemopreventive agents, some of which occur naturally in the diet. These agents include beta-carotene, retinyl palmitate, 13-cis-retinoic acid, riboflavin, canthaxanthin, and folic acid. Not all of these agents were effective. The success of the treatment depended on both the agent being used and the population being studied. The results of these studies suggest that successful intervention with chemopreventive agents will depend on tailoring treatment regimens to specific populations. The micronucleus test can be used along with other biological end points to obtain an early indication of the efficacy of chemopreventive agents in altering biological changes associated with carcinogenesis in tissues of high-risk individuals.