PERFORATION AND HEMORRHAGE FROM DUODENAL ULCER DURING THE ADMINISTRATION OF RAUWOLFIA SERPENTINA: REPORT OF FIVE CASES
Authors: W O WEST
Journal: Annals of Internal Medicine (1958)

Article1 May 1958PERFORATION AND HEMORRHAGE FROM DUODENAL ULCER DURING THE ADMINISTRATION OF RAUWOLFIA SERPENTINA: REPORT OF FIVE CASESWILK O. WEST, M.D.WILK O. WEST, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-5-1033 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONRauwolfia serpentina, or snakeroot, is a drug which has been used in Indian medicine for the past 30 centuries for a host of human maladies, including anxiety, snakebite, psychoses, epilepsy and insomnia. It was named after the German physician, Leonhard Rauwolf.This agent has but recently (within the last three years) come into its own in this country, and has been a valuable adjunct in the treatment of hypertension1-3and emotional disorders.4, 5Most of the effects1and side-effects6of serpentina are well recognized, but probably are not appreciated to the fullest extent. Several disturbing reports have appeared in...Bibliography1. Moyer JH: Drug therapy (rauwolfia) of hypertension. 1. Pharmacodynamics of rauwolfia, Arch. Int. Med. 96: 518, 1955. CrossrefGoogle Scholar2. AllenBarkerHinesKvaleSchickGiffordEstes EVNWEAWFRMRWJE: Medical treatment of hypertension, Proc. Staff Meet., Mayo Clin. 29: 459, 1954. MedlineGoogle Scholar3. Moyer JH: The treatment of hypertensive emergencies, GP 15: 104, 1957. Google Scholar4. Altschule MD: Use of chlorpromazine and reserpine in mental disorders, New England J. Med. 254: 515, 1956. CrossrefMedlineGoogle Scholar5. NoceWilliams RHDB: Reserpine (Serpasil) in the management of the mentally ill and mentally retarded, J. A. M. A. 156: 21, 1954. MedlineGoogle Scholar6. KlineBarsaGosline NSJE: Management of the side effects of reserpine and combined reserpine-chlorpromazine treatment, Dis. Nerv. System 17: 352, 1956. MedlineGoogle Scholar7. WoffordCummins JDAJ: Hemorrhage from duodenal ulcer during the administration of reserpine, New England J. Med. 255: 1193, 1956. CrossrefMedlineGoogle Scholar8. HussarBruno AEE: Acute duodenal ulcer associated with reserpine therapy, Gastroenterology 31: 515, 1956. CrossrefGoogle Scholar9. Hollister LE: Hematemesis and melena complicating treatment with rauwolfia alkaloids, Arch. Int. Med. 99: 218, 1957. CrossrefGoogle Scholar10. DillonSwain DJM: Gastrointestinal hemorrhage as a result of reserpine administration, Am. J. Psychiat. 113: 462, 1956. CrossrefMedlineGoogle Scholar11. ClarkSchneider MLEM: Effects of intravenous reserpine on gastric acidity in man, Gastroenterology 29: 877, 1955. CrossrefMedlineGoogle Scholar12. SchneiderClark EMML: Hyperchlorhydria induced by intravenous reserpine: response to various therapeutic agents, Am. J. Digest. Dis. 1: 22, 1956. CrossrefMedlineGoogle Scholar13. HaverbackStevensonSjoerdsmaTerry BJTDALL: Effects of reserpine and chlorpromazine on gastric secretions, Am. J. M. Sc. 230: 601, 1955. CrossrefMedlineGoogle Scholar14. Drenick EJ: Reserpine in peptic ulcer, Am. J. Digest. Dis. 1: 521, 1956. CrossrefMedlineGoogle Scholar15. HaverbackDutcherShoreTomichTerryBrodie BJTFPAEGLLBB: Serotonin changes in platelets and brain induced by small daily doses of reserpine. Lack of effect of depletion of platelet serotonin on hemostatic mechanisms, New England J. Med. 256: 343, 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Charleston, West Virginia*Received for publication April 9, 1957.From the Department of Internal Medicine, Charleston Memorial Hospital, Charleston, West Virginia.Requests for reprints should be addressed to Wilk O. West, M.D., Chief Medical Resident, Charleston Memorial Hospital, Box 3189, Charleston, West Virginia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEssential HypertensionMarginal Ulcer: A Guide to ManagementRecurrent Peptic UlcerEffects of oral administration of PGE2 on gastric secretion and experimental peptic ulcerationsMultiple Reactions to Antihypertensive Agents during Treatment of Malignant HypertensionH. MITCHELL PERRY JR., M.D.Ulcerogenic drugs and technicsNeuroleptica und AntihistaminicaUlcerogenic drugs 1 May 1958Volume 48, Issue 5Page: 1033-1039KeywordsDuodenal ulcersGastric ulcersHemorrhageHospital medicineHypertensionIngestionInsomniaOral administrationPeptic ulcersPsychoses ePublished: 1 December 2008 Issue Published: 1 May 1958 PDF downloadLoading ...