ALARMING NEUROMUSCULAR REACTIONS DUE TO PROCHLORPERAZINE
Authors: J GAILITIS, R R KNOWLES, A LONGOBARDI
Journal: Annals of Internal Medicine (1960)

Article1 March 1960ALARMING NEUROMUSCULAR REACTIONS DUE TO PROCHLORPERAZINEJANIS GAILITIS, M.D., RICHARD R. KNOWLES, M.D., ARTURO LONGOBARDI, M.D.JANIS GAILITIS, M.D.Search for more papers by this author, RICHARD R. KNOWLES, M.D.Search for more papers by this author, ARTURO LONGOBARDI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-3-538 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPeculiar aneuromuscular reactions of the dystonic type have been reported as infrequent side-effects of prochlorperazine therapy.1 This so-called extrapyramidal syndrome presents a frightening experience to the patient and a diagnostic challenge for the physician. Four such episodes were observed in Newport Hospital in the years 1958-1959.CASE REPORTSCase 1. A 25 year old white female was admitted on April 19, 1958, with low abdominal pain, fever and vomiting. She had been discharged 12 days previously after a dilatation and curettage for diagnostic purposes. A tentative diagnosis of pelvic inflammatory disease was made, and treatment with parenteral penicillin and streptomycin...Bibliography1. EnglandSchwabb ACRS: The management of Parkinson's disease, Arch. Int. Med. 104: 439-468, 1959. CrossrefMedlineGoogle Scholar2. DelayDenikerGreenMordret JPAM: Le syndrome excitomoteur provoqué par les medicaments neuroleptiques, Presse méd. 65: 1771-1774, 1957. MedlineGoogle Scholar3. O'Hara VS: Extrapyramidal reactions in patients receiving prochlorperazine, New England J. Med. 259: 826-828, 1958. CrossrefMedlineGoogle Scholar4. ChristianPaulson CDG: Severe motility disturbance after small dose of prochlorperazine, New England J. Med. 259: 826-830, 1958. CrossrefMedlineGoogle Scholar5. GraffPhillipsGentry TDOCWD: Clonic convulsions after the oral use of perphenazine (Trilafon), J. A. M. A. 169: 834-835, 1959. CrossrefMedlineGoogle Scholar6. Graham GK: Severe side reaction to therapeutic dosage of perphenazine, New England J. Med. 260: 1133, 1959. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JANIS GAILITIS, M.D.; RICHARD R. KNOWLES, M.D.; ARTURO LONGOBARDI, M.D.*Received for publication November 6, 1959.From Newport Hospital, Newport, Rhode Island.†Available as Compazine from Smith, Kline and French Laboratories, Philadelphia.Requests for reprints should be addressed to Richard R. Knowles, M.D., 230 Bellevue Avenue, Newport, Rhode Island. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAcute dystonic reactions from “Street valium”Extended therapy for acute dystonic reactionsAntiparkinsonian and antidyskinetic drugsSerious reactions to phenothiazinesA Comparison of Chlorpromazine-Induced Extrapyramidal Syndrome in Male and Female RatsHYSTERIA AND DRUG-INDUCED DYSTONIAPhenothiazinesPhenothiazine BibliographiesUnusual Manifestations Associated with a Phenothiazine-Induced Dystonic ReactionPhenothiazine und Azaphenothiazine als Heilmittel 1 March 1960Volume 52, Issue 3Page: 538-543KeywordsAbdominal painFeversPathogenesisPelvic inflammatory diseasePenicillinSchizophreniaSedationStreptomycinVomiting ePublished: 1 December 2008 Issue Published: 1 March 1960 PDF downloadLoading ...