Hepatotoxicity Complicating Flutamide Treatment of Hirsutism
Authors: Clarissa Wallace
Journal: Annals of Internal Medicine (1993)

Letters1 December 1993Hepatotoxicity Complicating Flutamide Treatment of HirsutismClarissa Wallace, MD, E. A. Lalor, MD, and Constance L. Chik, MDClarissa Wallace, MD, E. A. Lalor, MD, and Constance L. Chik, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-11-199312010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Hepatotoxicity, said to be an infrequent complication of treatment with the oral antiandrogen flutamide (Eulexin, Schering, Kenilworth, New Jersey) [1], was reported by Wysowski and colleagues in 19 patients treated with the drug for benign and malignant prostatic diseases [2]. We report the first association of flutamide with serious hepatotoxicity in a woman using the drug for the treatment of hirsutism [3].In January 1993, a 20-year-old East Indian woman presented with a history of menstrual irregularity and increasing hirsutism since her menarche at age 12. She had been receiving oral contraceptive pills since age 15 and ...References1. Gomez JL, Dupont A, Cusan L, Tremblay M, Suburu R, Lemay M, et al. Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients. Am J Med. 1992; 92:465-70. Google Scholar2. Wysowski DK, Frieman JP, Tourtelot JB, Horton ML. Fatal and nonfatal hepatotoxicity associated with flutamide. Ann Intern Med. 1993; 118:860-4. Google Scholar3. Cusan L, Dupont A, Belanger A, Tremblay RR, Manhes G, Labrie F. Treatment of hirsutism with the pure antiandrogen flutamide. J Am Acad Dermatol. 1990; 23:462-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEvaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society* Clinical Practice GuidelineEvaluation and treatment of hirsutismHepatotoxicity with low- and ultralow-dose flutamide: a surveillance study on 203 hyperandrogenic young femalesRetrospective, observational study on the effects and tolerability of flutamide in a large population of patients with acne and seborrhea over a 15-year periodProspective Cohort Study on the Effects and Tolerability of Flutamide in Patients with Female Pattern Hair LossHirsutism and virilizationDiagnosis and management of hirsutismManagement of Unwanted HairSynergy of Eflornithine Cream with Laser and Light-Based Systems for Hair ManagementFatal liver complications with flutamideLong-term, low-dose flutamide does not cause hepatotoxicity in hyperandrogenic womenAbsence of hepatotoxicity after long-term, low-dose flutamide in hyperandrogenic girls and young womenHepatitis tóxica tras tratamiento con flutamidaHepatotoxicity Induced by Antiandrogens: A Review of the LiteraturePolycystic Ovary SyndromeFulminant liver failure associated with flutamide therapy for hirsutismA Brief Review of Cancer ChemopreventionEffect of finasteride in idiopathic hirsutismHirsutes II: TreatmentThe Effect of a Pure Antiandrogen Receptor Blocker, Flutamide, on the Lipid Profile in the Polycystic Ovary SyndromeANTIANDROGEN THERAPY IN DERMATOLOGYANTIANDROGEN AND HORMONAL TREATMENT OF ACNEPolycystic ovary syndrome: Clinical aspectsFlutamide HepatotoxicityFlutamide HepatotoxicityTreatment of hyperandrogenism in womenComparison of flutamide and cyproterone acetate in the treatment of hirsutism: A randomized controlled trialHEPATOTOXICITY OF ANTICHOLESTEROL, CARDIOVASCULAR, AND ENDOCRINE DRUGS AND HORMONAL AGENTSAndrogenic disorders of women: Diagnostic and therapeutic decision makingSafety of Flutamide?**This letter expresses the views of the authors and not necessarily the official position of the Food and Drug Administration.Flutamide 1 December 1993Volume 119, Issue 11Page: 1150KeywordsBilirubinDrugsLiverOral contraceptive therapyProstate diseasesProthrombin timePruritusSubcutaneous injectionsUltrasound imagingUrine Issue Published: 1 December 1993 Copyright & PermissionsCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...