tbuckley/cabot-search huggingface dataset:
732-3 Improved Results After Nonfenestrated Fontan Operation in Patients Less than 4 Years Old
Authors: Frank Cetta, Patrick W. O’Leary, Robert H. Feldt, Douglas D. Mair, Kenneth P. Offord, Francisco J. Puga, Hartzell V. Schaff, Gordon K. Danielson
Journal: Journal of the American College of Cardiology (1995)
Increasing prevalence of breast-feeding.
Authors: E C Coles, S Cotter, H B Valman
Journal: BMJ (1978)

Two studies were performed to gauge the prevalence of and attitudes towards breast-feeding. Mothers delivered in one month in 1975 and in one month in 1977 were sent a questionnaire one month later to determine whether they were breast-feeding their babies; those that were received a second questionnaire at three months. The prevalence of breast-feeding increased significantly between 1975 and 1977, and in both periods primiparas were more likely to breast-feed than multiparas. A survey of mothers9 intentions to breast-feed showed that there were no significant racial differences, but that 82% of women in social classes I and II intended to breast-feed compared with 54% in classes IV and V. These results show that, although the level of breast-feeding was high in 1975, a campaign directed at mothers, doctors, midwives, and health visitors did increase the prevalence of breast-feeding.
FAILURE OF PHYTOHAEMAGGLUTININ TO EFFECT EPIDERMAL DNA SYNTHESIS.
Authors: COURTNEY HODGSON, ELIZABETH HELL
Journal: British Journal of Dermatology (1966)

Journal Article FAILURE OF PHYTOHAEMAGGLUTININ TO EFFECT EPIDERMAL DNA SYNTHESIS. Get access COURTNEY HODGSON, COURTNEY HODGSON Department of Dermatology, the General Hospital, Birmingham, 4 and the Medical Research Council, Unit for Research on the Experimental Pathology of the Skin, Medical School, University, Birmingham, 15 Search for other works by this author on: Oxford Academic Google Scholar ELIZABETH HELL ELIZABETH HELL Department of Dermatology, the General Hospital, Birmingham, 4 and the Medical Research Council, Unit for Research on the Experimental Pathology of the Skin, Medical School, University, Birmingham, 15 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 78, Issue 10, 1 October 1966, Pages 525–527, https://doi.org/10.1111/j.1365-2133.1966.tb12140.x Published: 01 October 1966
Effect of resin hydrophilicity and temperature on water sorption of dental adhesive resins
Authors: Cynthia K.Y. Yiu, Nigel M. King, Marcela R.O. Carrilho, Salvatore Sauro, Frederick A. Rueggeberg, Carlo Prati, Ricardo M. Carvalho, David H. Pashley, Franklin R. Tay
Journal: Biomaterials (2005)
[222] RISK OF LIVER CIRRHOSIS ASSOCIATED WITH GENOTYPE AND MUTANTS OF HEPATITIS B VIRUS
Authors: Y.L. Chen, P.J. Chen, H.I. Yang, U.H. Iloeje, J. Su, CL. Jen, S.H. Yeh, S.N. Lu, S.L. You, C.J. Chen
Journal: Journal of Hepatology (2007)
The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes
Authors: Claudia Rohr, Jürgen Prestel, Laurence Heidet, Hiltraud Hosser, Wilhelm Kriz, Randy L. Johnson, Corinne Antignac, Ralph Witzgall
Journal: Journal of Clinical Investigation (2002)

Patients with nail-patella syndrome often suffer from a nephropathy, which ultimately results in chronic renal failure. The finding that this disease is caused by mutations in the transcription factor LMX1B, which in the kidney is expressed exclusively in podocytes, offers the opportunity for a better understanding of the renal pathogenesis. In our analysis of the nephropathy in nail-patella syndrome, we have made use of the Lmx1b knockout mouse. Transmission electron micrographs showed that glomerular development in general and the differentiation of podocytes in particular were severely impaired. The glomerular capillary network was poorly elaborated, fenestrae in the endothelial cells were largely missing, and the glomerular basement membrane was split. In addition podocytes retained a cuboidal shape and did not form foot processes and slit diaphragms. Expression of the α4 chain of collagen IV and of podocin was also severely reduced. Using gel shift assays, we demonstrated that LMX1B bound to two AT-rich sequences in the promoter region of NPHS2, the gene encoding podocin. Our results demonstrate that Lmx1b regulates important steps in glomerular development and establish a link between three hereditary kidney diseases: nail-patella syndrome (Lmx1b), steroid-resistant nephrotic syndrome (podocin), and Alport syndrome (collagen IV α4).
Analysis of p73 expression pattern in acute myeloid leukemias: lack of ΔN-p73 expression is a frequent feature of acute promyelocytic leukemia
Authors: M G Rizzo, E Giombini, D Diverio, M Vignetti, A Sacchi, U Testa, F Lo-Coco, G Blandino
Journal: Leukemia (2004)
Manual of Fracture Bracing
Authors: J B King
Journal: Annals of the Rheumatic Diseases (1985)

We investigated the effects of transforming growth factor α (TGF-α) on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes and examined the influence of α and β adrenoceptor agonists on the TGF-α-induced responses. TGF-α (1.0 ng/ml) produced a 4.1-fold elevation of DNA synthesis during 3 h of culture and a 1.2-fold increase in the nucleus number (proliferation) during 4 h of culture at a cell density of 3.3 × 10<sup>4</sup> cells/cm<sup>2</sup>. The TGF-α-induced hepatocyte DNA synthesis and proliferation were dose-dependent at EC<sub>50</sub> values of 0.36 ng/ml and 0.45 ng/ml, respectively. Hepatocyte DNA synthesis and proliferation induced by 1.0 ng/ml TGF-α did not reduce even at higher initial plating densities (5.0 × 10<sup>4</sup> and 1.0 × 10<sup>5</sup> cells/cm<sup>2</sup>). Increasing concentrations of the β<sub>2</sub> adrenoceptor agonist metaproterenol (10<sup>−7</sup>–10<sup>−6</sup> M) markedly reduced the proliferative effects of TGF-α, whereas those of the α<sub>2</sub> adrenoceptor agonist 5-bromo-6-[2-imidazolin-2-yl-amino]-quinoxaline (UK-14304; 10<sup>−6</sup>–10<sup>−5</sup> M) and the α<sub>1</sub>adrenoceptor agonist phenylephrine (10<sup>−7</sup>–10<sup>−6</sup> M) significantly potentiated the TGF-α action. The proliferative effects of TGF-α (1.0 ng/ml) were not affected significantly by a monoclonal antiepidermal growth factor receptor antibody (1–100 ng/ml) and were almost completely blocked by specific inhibitors of signal transducers such as genistein (10<sup>−5</sup> M), 1–6[[17β-3methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1<i>H-</i>pyrrol2,5-dione (U-73122; 0<sup>−5</sup> M), wortmannin (5 × 10<sup>−7</sup>M), sphingosine (5 × 10<sup>−6</sup> M), 2′-amino-3′-methoxyflavone (PD98059; 5 × 10<sup>−5</sup> M), and rapamycin (10 ng/ml). These results suggest that among the elements that link signals of cell surface receptor to the nucleus, the proliferative action of TGF-α is mediated, at least, by tyrosine kinase, phospholipase C, phosphatidylinositol 3-kinase, protein kinase C, mitogen-activated protein kinase kinase, and ribosomal protein p70 S6 kinase.
Imaging the Modulation of Adenoviral Kinetics and Biodistribution for Cancer Gene Therapy
Authors: Joseph D Mocanu, Kenneth W Yip, Nehad M Alajez, Wei Shi, Jian-Hua Li, Sarah J Lunt, Eduardo H Moriyama, Brian C Wilson, Michael Milosevic, Kwok-Wai Lo, Nico van van Rooijen, Pierre Busson, Carlo Bastianutto, Fei-Fei Liu
Journal: Molecular Therapy (2007)

See page 841 To explore systemic utilization of Epstein-Barr virus (EBV)-specific transcriptionally targeted adenoviruses, three vectors were constructed to examine kinetics, specificity, and biodistribution: adv.oriP.luc, expressing luciferase under EBV-specific control; adv.SV40luc, expressing luciferase constitutively; and adv.oriP.E1A.oriP.luc, a conditionally replicating adenovirus, expressing both luciferase and E1A. Bioluminescence imaging (BLI) was conducted on tumor-bearing severe combined immunodeficient (SCID) mice (C666-1, EBV-positive human nasopharyngeal cancer) treated intravenously (i.v.) with 3 × 108 infectious units (ifu) of the adenoviral vectors. At 72 hours, adv.oriPluc demonstrated an 8.4-fold higher tumor signal than adv.SV40luc; adv.oriP.E1A.oriP.luc was 26.7-fold higher; however, a significant liver signal was also observed, necessitating further action to improve biodistribution. Several compounds were examined to this end, including norepinephrine, serotonin, clodronate liposomes, and STI571, to determine whether any of these measures could improve adenoviral biodistribution. Each of these interventions was assessed using BLI in mice i.v. injected with adv.oriP.luc. STI571 achieved the highest increase in tumor-to-liver ratio (TLR; 6.6-fold), which was associated with a 59% reduction in tumor interstitial fluid pressure (IFP) along with a decrease in platelet-derived growth factor-β receptor (PDGFβR) activation. This study reports the favorable modulation by STI571 of the biodistribution of adenoviral vectors, providing a potential approach to improving therapeutic outcome.
Concentrations of organic contaminants in mollusks and sediments at NOAA National Status and Trend sites in the coastal and estuarine United States.
Authors: T P O'Connor
Journal: Environmental Health Perspectives (1991)

Mean concentrations of PAHs, PCBs, and DDT in mollusks and sediments at sites in the National Status and Trends Program (NST) are distributed in log-normal fashion. The dry weight-based chlorinated organic concentrations in mollusks generally exceed those in nearby sediments by an order of magnitude. PAHs are found at similar concentrations in sediments and mollusks. Highest concentrations of PCBs and DDT in mollusks are in the ranges of 1000 to 4000 ng/g (dry) and 400 to 1000 ng/g (dry), respectively. The highest PAH concentrations in sediments are in the 10,000 to 50,000 ng/g (dry) range. While higher concentrations of contaminants can be found by sampling localized hot spots, the NST data represent the distribution of concentrations over general areas of the coastal United States.
Regulation of Urokinase Receptor Expression: Interpreting Data in the Absence of Statistics
Authors: John W. Upham, Stephanie T. Yerkovich
Journal: American Journal of Respiratory and Critical Care Medicine (2009)

Dr. Bhandary and colleagues have published a study examining the post-transcriptional regulation of urokinase receptor expression in relation to acute lung injury (1). However, the apparent lack of any statistical analyses makes the detailed mechanistic experiments difficult to interpret. It is unusual to come across a research paper in the Journal that does not contain a single P value! The METHODS section of the article contains no description of the statistical approach, and aside from providing the means and standard deviations for the experiment, there is no indication that the authors have performed any comparative statistical analyses. Analysis of variance and a Student’s t test might be appropriate, assuming the data are normally distributed. Whereas cell lines and in-bred strains of mice typically provide reproducible data, this does not justify a lack of statistical analysis. Careful attention to these issues by authors is important for readers of the Journal so that the experimental observations can be properly interpreted.
SUPPRESSION OF ADJUVANT DISEASE IN THE RAT BY HETEROLOGOUS ANTILYMPHOCYTE GLOBULIN
Authors: H. L. F. Currey, Morris Ziff
Journal: The Journal of Experimental Medicine (1968)

The effect of antilymphocyte globulin (ALG) on adjuvant arthritis, an immunologically induced disease in the rat, was studied. ALG was prepared from the serum of rabbits immunized against rat lymphocytes. Adjuvant arthritis was induced in rats by a single intracutaneous injection of Freund's complete adjuvant; after 9 to 12 days, all control rats developed polyarthritis. Administration of antilymphocyte globulin about the time of adjuvant injection produced marked inhibition of clinical disease. Some suppression was apparent even when ALG was started after the onset of arthritis. Rats receiving ALG remained conspicuously healthy compared to controls. Urinary findings and renal histology showed no evidence of nephritis. The results of serum corticosterone determinations made it unlikely that adrenal stimulation contributed to the actions of ALG. Antilymphocyte preparations lowered peripheral lymphocyte counts and suppressed primary antibody responses to sheep erythrocytes, but had little effect on the skin reaction to PPD, even in rats protected from arthritis. All rats given ALG developed antibodies to rabbit globulin; there was no evidence that ALG inhibited the appearance of antibodies to itself, and prior hyperimmunization of rats with rabbit globulin did not interfere with the biological activity of ALG subsequently injected. Antisera produced separately against lymph node and thymus cells had identical properties with regard to agglutination of lymphocytes and thymus cells. Administered to rats, these preparations were equally potent in lowering lymphocyte counts and suppressing both adjuvant arthritis and the primary antibody response to sheep erythrocytes. It is concluded that ALG, as used in these experiments, is a potent immunosuppressive agent without obvious toxic effects.
I-131 Visualization of Thoracic Aortic Aneurysm After Radioiodine Administration for Thyroid Carcinoma
Authors: Luisa M. Mena Bares, Juan Antonio Vallejo Casas, Estefanía Moreno Ortega, Ramón del Real Nuñez, Francisco R. Maza Muret, José María Latre Romero
Journal: Clinical Nuclear Medicine (2008)

A 69-year-old woman diagnosed with papillary thyroid carcinoma was treated with total thyroidectomy and radioiodine ablation. At follow-up a whole body I-131 scan after injection of rhTSH was performed. This scan shows unexpected uptake in the superior mediastinum, initially misinterpreted as metastases (Tg level: 6.8 ng/mL). CT and digital subtraction angiography (DSA) confirmed that this finding was due to an aortic aneurysm. This vascular malformation was embolized and endoprosthesis was performed using a Seldinger's technique.
Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID, and IIE).
Authors: T S Zimmerman, J A Dent, Z M Ruggeri, L H Nannini
Journal: Journal of Clinical Investigation (1986)

We have evaluated the subunit composition of plasma von Willebrand factor (vWF) and found evidence that cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease (vWD), but decreased or absent in variants with aberrant structure of individual oligomers. vWF was rapidly purified from plasma on an analytical scale by monoclonal antibody immunoaffinity chromatography in the presence of protease inhibitors. After reduction and electrophoresis in 5% polyacrylamide gels containing sodium dodecyl sulfate, fragments of 189, 176, and 140 kD, as well as the predominant 225-kD subunit, were identified in plasma vWF from 25 normal individuals. The vWF polypeptides were detected by immunoblotting with a mixture of 55 anti-vWF monoclonal antibodies followed by 125I-rabbit anti-mouse antibody and autoradiography. In five individuals with type IIA and five individuals with type IIB vWD, the proportions of 176 and 140-kD fragments were increased relative to the intact 225-kD subunit, as determined by excising each band and quantitating incorporated radioactivity. In contrast, these fragments were either not detectable or were present in only trace amounts in variants with abnormal structure of individual oligomers (types IIC and IID, and a new variant, type IIE vWD). The results reported here provide evidence that absence of large vWF multimers in these two groups of variants results from different mechanisms. In addition, they demonstrate that partial cleavage of the plasma vWF subunit is a normal event.
Candida albicans Morphology and Dendritic Cell Subsets Determine T Helper Cell Differentiation
Authors: Sakeen W. Kashem, Botond Z. Igyártó, Maryam Gerami-Nejad, Yosuke Kumamoto, Javed Mohammed, Elizabeth Jarrett, Rebecca A. Drummond, Sandra M. Zurawski, Gerard Zurawski, Judith Berman, Akiko Iwasaki, Gordon D. Brown, Daniel H. Kaplan
Journal: Immunity (2015)
Guidelines of care for Mohs micrographic surgery
Authors: None Guidelines/Outcomes Committee, Lynn A Drake, Scott M Dinehart, Robert W Goltz, Gloria F Graham, Maria K Hordinsky, Charles W Lewis, David M Pariser, Stuart J Salasche, John W Skouge, Maria L Chanco Turner, Stephen B Webster, Duane C Whitaker, Barbara Butler, Barbara J Lowery
Journal: Journal of the American Academy of Dermatology (1995)
(43) Cicatricial pemphigoid in a D-penicillamine treated patient with rheumatoid arthritis
Authors: D. Shuttleworth, R.A.C. Graham-Brown
Journal: British Journal of Dermatology (1985)

Journal Article (43) Cicatricial pemphigoid in a D‐penicillamine treated patient with rheumatoid arthritis Get access D. Shuttleworth, D. Shuttleworth Leicester Royal Infirmary, Leicester Search for other works by this author on: Oxford Academic Google Scholar R.A.C. Graham‐Brown R.A.C. Graham‐Brown Leicester Royal Infirmary, Leicester Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 113, Issue s29, 1 July 1985, Pages 89–90, https://doi.org/10.1111/j.1365-2133.1985.tb13058.x Published: 01 July 1985
Nearly Two Millenia Later, 'Under the Volcano' Military Medicine Stresses Disaster Preparedness
Authors: Phil Gunby
Journal: JAMA (1994)

TOWERING NEARBY is Mount Vesuvius, the volcano that—1915 years ago today—became active after centuries of quiescence and buried the Roman communities of Pompeii, Herculaneum, and Stabiae under 20 m of heated mud and ash. And in a volcanic crater of its own, amid escaping jets of steam and a strong sulphuric odor, is the US Naval Hospital, Naples, Italy. Because of its location and for a variety of other reasons, the hospital's staff and US military medical personnel from elsewhere in Europe have just completed their fourth major disaster-preparedness exercise since 1987. It tested their ability to respond—successfully, as it turned out—"to a series of seismic events that render the hospital unusable and produce a number [224] of casualties and displaced persons." <h3>Difficult Decisions</h3> "In my opinion," says US Navy LT Joseph DaCorta, MSC, head of the hospital's Plans and Programs Department and the exercise's coordinator and planner, "the single
Improving Outcomes in Pregnant Women With Type 1 Diabetes
Authors: Moshe Hod, Lois Jovanovic
Journal: Diabetes Care (2007)

Despite the good intentions of the St. Vincent Declaration to reduce adverse outcomes down to that seen in nondiabetic pregnant women, maternal and perinatal adverse outcomes continue to be associated with type 1 diabetes. Optimized glycemia has been shown to be the best management for pregnant type 1 diabetic women (1). It is recognized that high A1C levels are associated with adverse outcomes. Indeed, glycemic control early in pregnancy appears to be critical in the prevention of congenital abnormalities in offspring of type 1 diabetic women (2). Therefore, strict targets of normal A1C are recommended for women planning pregnancy (3). Meeting this strict target A1C is undeniably challenging …
Change in moles linked to use of unlicensed "sun tan jab"
Authors: E. A Langan, D. Ramlogan, L. A Jamieson, L. E Rhodes
Journal: BMJ (2009)

We draw attention to a new factor complicating presentation and diagnosis of pigmented lesions1: unlicensed use of melanotropic peptides offered online as Melanotan I and II.

Two patients presented to our dermatology clinic with rapidly changing moles and a conspicuous tan, despite their sun reactive skin type I/II (sunburns easily, suntans poorly). They were both sunbed users. One, a woman of 42, reported two moles on her …
NECROPSY REPORTS ON PERSONS DYING SHORTLY AFTER THE EXTRACTION OF TEETH
Authors: RICHARD C. BUCKLEY
Journal: JAMA (1927)

From time to time attention has been called to the untoward results following the extraction of teeth. The clinical-pathologic reports of three deaths, occurring within a short time after the removal of teeth, are presented to emphasize again the dangers associated with the extraction of teeth. <h3>REPORT OF CASES</h3><h3>Case 1.</h3><h3>—History.</h3> —A white man, farmer, aged 44, had had diabetes existing over a period of three years. The patient failed to follow dietary regulations during this period and lost about 25 pounds (11 Kg.) and became weak. He had considerable trouble with all of his teeth, and on April 20, 1920, had two molars removed under gas anesthesia. Four days later the remaining teeth were extracted under gas anesthesia. Considerable hemorrhage followed the extractions. During the next five days the patient became seriously ill and on May 1 became comatose. The family physician recognized the condition as one of
Treatment of <i>Staphylococcus aureus</i> bacteraemia
Authors: Charis Marwick, William J Olver
Journal: BMJ (2006)

EDITOR—In his editorial on Staphylococcus aureus bacteraemia Paul says that some doubt remains about the optimal duration of antibiotic treatment.1 A prospective study of 278 cases of S aureus bacteraemia (mainly methicillin sensitive strains) looked at potential risk factors and outcome, using multiple regression analysis.2 Factors related to death …
Development of human fetal kidney in obstructive uropathy: Correlations with ultrasonography and urine biochemistry
Authors: Farida Daïkha-Dahmane, Marc Dommergues, Françoise Muller, Françoise Narcy, Mireille Lacoste, Agnes Beziau, Yves Dumez, Marie-Claire Gubler
Journal: Kidney International (1997)
Molecular Pathogenesis of Pseudohypoaldosteronism Type II: Generation and Analysis of a Wnk4 Knockin Mouse Model
Authors: Sung-Sen Yang, Tetsuji Morimoto, Tatemitsu Rai, Motoko Chiga, Eisei Sohara, Mayuko Ohno, Keiko Uchida, Shih-Hua Lin, Tetsuo Moriguchi, Hiroshi Shibuya, Yoshiaki Kondo, Sei Sasaki, Shinichi Uchida
Journal: Cell Metabolism (2007)
THE EFFECTS OF A 2-NAPHTHOL PEELING PASTE ON SEBACEOUS GLANDS REMOTE FROM ITS SITE OF APPLICATION
Authors: E. W. POWELL
Journal: British Journal of Dermatology (1970)

Summary— The sebum excretion rate and chemical composition of sebum from the foreheads of 4 young men with acne vulgaris were changed markedly when a 2-naphthol paste was applied to other skin sites. The excretion rate, free fatty acid content and wax ester content fell but the triglyceride content increased. Recurrence of acne on stopping treatment was associated with an increase in wax ester content and a decrease in triglyceride content but little change in excretion rate and free fatty acid content.
Behçet Society Formed
Authors: Rebecca Voelker
Journal: JAMA (2000)

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