Heparin Activity in Systemic Mastocytosis
Authors: EARL W. CAMPBELL
Journal: Annals of Internal Medicine (1979)

Brief Reports1 June 1979Heparin Activity in Systemic MastocytosisEARL W. CAMPBELL JR., M.D., DAVID HECTOR, M.D., VEENA GOSSAIN, M.D.EARL W. CAMPBELL JR., M.D., DAVID HECTOR, M.D., VEENA GOSSAIN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-90-6-940 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSystemic mastocytosis is characterized by mast-cell infiltration of various organs, particularly dermis and reticuloendothelial systems. The disorder is rare in blacks (1). In children the skin lesions most often disappear spontaneously. The pathognomonic skin lesions are multiple, irregular, reddish-brown macules and papules that urticate when stroked. Benign aspects of the disorder include flushing, itching, and urticaria. Less frequently vomiting, syncope, or shock may occur intermittently. Rare complications include respiratory distress and duodenal ulcer. Mast cells are known to contain histamine and heparin (2, 3). Most symptoms are presumed to be a result of histamine release from mast cells and often...References1. LANTISKOBLENZER JP: Solitary mast cell tumor. Arch Dermatol 99:60-63, 1969 CrossrefMedlineGoogle Scholar2. DEMIS J: Mast cell disease, in Clinical Dermatology, Section 4, Unit 4-11, Hagerstown, Maryland, Harper and Row, 1977, pp. 1-27 Google Scholar3. RILEY J: Functional significance of histamine and heparin in tissue mast cells. Ann NY Acad Sci 103:151-178, 1963 CrossrefMedlineGoogle Scholar4. PENNER J: Experience with a thrombin clotting time assay for measuring heparin activity. Am J Clin Pathol 61:645-653, 1974 CrossrefMedlineGoogle Scholar5. PENNER J: Blood Coagulation Manual (suppl). Ann Arbor, Michigan, University of Michigan Press, 1975 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Michigan State University School of Medicine East Lansing, Michigan PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySystemic Mastocytosis and Mast Cell TumorsSystemic Mastocytosis and Mast Cell TumorsUrinary 11β-PGF2α and N-methyl histamine correlate with bone marrow biopsy findings in mast cell disordersBleeding diathesis in patients with mast cell activation diseaseMastocytosis: a rare case of anaphylaxis in paediatric age and literature reviewMast Cell Mediators in Allergic Inflammation and MastocytosisSystemic Mastocytosis: Clinical Manifestations and Differential DiagnosisDiagnostic criteria and classification of mastocytosis: a consensus proposalClinical advances in mastocytosisThe mast cell and mast cell diseaseSystemic mastocytosis involving the mandibleDIFFUSE CUTANEOUS MASTOCYTOSIS: A RARE ENTITYSpleen findings in generalized mastocytosis. A clinicopathologic studyCalcium homeostasis in pregnancy during long-term heparin treatmentSystemic heparin-like activity in mastocytosisCase 7-1992Systemic mast cell disease associated with primary mediastinal germ cell tumorBiochemical Diagnosis of Systemic Mast Cell DisordersSystemic mast cell disease associated with primary mediastinal germ cell tumorThe osteoporosis of heparinotherapy and systemic mastocytosisLiver findings in generalized mastocytosis. A clinicopathologic studySystemic MastocytosisCarcinoid Syndrome and Disorders of Systemic Mast-Cell Activation Including Systemic MastocytosisMastocytosis: A ReviewHeparin-like Activity, Atopic Eczema, and Contact DermatitisC. BOINOT, J: MARTIN, M. LARREGUEBullous Mastocytosis: Diffuse Cutaneous Mastocytosis with Extensive Blisters Mimicking Scalded Skin Syndrome or Erythema MultiformeRecurrent syncope due to systemic mastocytosis.Mastocytosis and the mast cellSYSTEMIC MASTOCYTOSIS: A CASE REPORTOsteopeniaIdentification of Sulfated Mucopolysaccharides Including Heparin in the Lesional Skin of a Patient with Mastocytosis 1 June 1979Volume 90, Issue 6Page: 940-941KeywordsHeparinHistamineLesionsMast cellsPruritusShockSyncopeSystemic mastocytosisUrticariaVomiting Issue Published: 1 June 1979 PDF DownloadLoading ...