STUDIES OF URINARY PIGMENTS IN PELLAGRA AND OTHER PATHOLOGICAL STATES. II. THE EXCRETION OF PORPHYRIN AND THE UROROSEIN REACTION IN DOGS WITH EXPERIMENTAL BLACKTONGUE
Authors: John A. Layne, Cecil James Watson
Journal: Annals of Internal Medicine (1943)

Article1 August 1943STUDIES OF URINARY PIGMENTS IN PELLAGRA AND OTHER PATHOLOGICAL STATES. II. THE EXCRETION OF PORPHYRIN AND THE UROROSEIN REACTION IN DOGS WITH EXPERIMENTAL BLACKTONGUEJOHN A. LAYNE, M.D., CECIL JAMES WATSON, M.D., F.A.C.P.JOHN A. LAYNE, M.D.Search for more papers by this author, CECIL JAMES WATSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-2-200 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the preceding paper1and in previous communications2, 3it has been shown that the Beckh-Ellinger-Spies (B.E.S.) test4is due to urorosein and that positive reactions are correlated in all instances with positive Nencki-Sieber (N.S.) tests for urorosein. Distinct increases of coproporphyrin were noted in alcoholic,2but not in endemic pellagra.1, 3Even in the former, the amounts of porphyrin were insufficient to be productive of color in the B.E.S. test. In order to study the effect of nicotinic acid in the absence of complicating factors such as alcoholism or other coexisting disease, the following studies were carried out in...Bibliography1. WATSONLAYNE CJJA: Studies of urinary pigments in pellagra and other pathological states. I. Clinical observations, ANN. INT. MED., 1943, xviii, 183-199. Google Scholar2. WATSON CJ: The urinary pigments in four cases of alcoholic pellagra, Proc. Soc. Exper. Biol. and Med., 1938, xxxix, 514-518. CrossrefGoogle Scholar3. WATSON CJ: Further observations on the red pigments of pellagra urines, Proc. Soc. Exper. Biol. and Med., 1939, xii, 591-595. CrossrefGoogle Scholar4. BECKHELLINGERSPIES WPTD: Porphyrinuria in pellagra, Quart Jr. Med., 1937, vi, 305-319. Google Scholar5. GOLDBERGERWHEELERLILLIEROGERS JGARDLM: A further study of experimental blacktongue with special reference to the blacktongue preventive in yeast, Pub. Health Rep., 1928, xliii, 657-694. CrossrefGoogle Scholar6. SPIESARINGGELPERINBEAN TDCDJWB: The mental symptoms of pellagra. Their relief with nicotinic acid, Am. Jr. Med. Sci., 1938, cxcvi, 461-475. CrossrefGoogle Scholar7. SPIESVILTERASHE TDRWWF: Pellagra, beriberi and riboflavin deficiency in human subjects, Jr. Am. Med. Assoc., 1938, cxiii, 483-486. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, Minnesota*Received for publication August 13, 1942.From the Division of Internal Medicine, University of Minnesota Hospital, Minneapolis, Minnesota. Aided by grants from the John and Mary R. Markle Foundation, and the Research Fund of the Graduate School, University of Minnesota.†The nicotinic acid was supplied in a sterile solution combined with monoethanolamine ("Nicamin") through the courtesy of Abbott Laboratories, North Chicago, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byXVIII Hairy or Black TongueURINARY EXCRETION OF COPROPORPHYRIN IN NON-ALCOHOLIC PELLAGRA 1 August 1943Volume 19, Issue 2Page: 200-205KeywordsAlcoholismAlcoholsExcretionGraduate medical educationHospital medicineNiacinPorphyrinsResearch funding Issue Published: 1 August 1943 PDF downloadLoading ...