tbuckley/cabot-search huggingface dataset:
Thrombotic and necrotizing panniculitis associated with recombinant human granulocyte colony-stimulating factor treatment
Authors: O. Dereure, D. Bessis, T. Lavabre-Bertrand, C. Exbrayat, N. Fegueux, C. Biron, J-J. Guilhou
Journal: British Journal of Dermatology (2000)

Journal Article Thrombotic and necrotizing panniculitis associated with recombinant human granulocyte colony‐stimulating factor treatment Get access O. Dereure, O. Dereure Departments of Dermatology and Phlebology and *Haematological Diseases, and †Laboratory of Haematology, CHRU Montpellier, Hôpital Saint‐Eloi, 2 avenue Bertin Sens, 34265 Montpellier Cedex 5, France E‐mail: ofdereure@wanadoo.fr Search for other works by this author on: Oxford Academic Google Scholar D. Bessis, D. Bessis Departments of Dermatology and Phlebology and *Haematological Diseases, and †Laboratory of Haematology, CHRU Montpellier, Hôpital Saint‐Eloi, 2 avenue Bertin Sens, 34265 Montpellier Cedex 5, France E‐mail: ofdereure@wanadoo.fr Search for other works by this author on: Oxford Academic Google Scholar T. Lavabre‐Bertrand, T. Lavabre‐Bertrand Departments of Dermatology and Phlebology and *Haematological Diseases, and †Laboratory of Haematology, CHRU Montpellier, Hôpital Saint‐Eloi, 2 avenue Bertin Sens, 34265 Montpellier Cedex 5, France E‐mail: ofdereure@wanadoo.fr Search for other works by this author on: Oxford Academic Google Scholar C. Exbrayat, C. Exbrayat Departments of Dermatology and Phlebology and *Haematological Diseases, and †Laboratory of Haematology, CHRU Montpellier, Hôpital Saint‐Eloi, 2 avenue Bertin Sens, 34265 Montpellier Cedex 5, France E‐mail: ofdereure@wanadoo.fr Search for other works by this author on: Oxford Academic Google Scholar N. Fegueux, N. Fegueux Departments of Dermatology and Phlebology and *Haematological Diseases, and †Laboratory of Haematology, CHRU Montpellier, Hôpital Saint‐Eloi, 2 avenue Bertin Sens, 34265 Montpellier Cedex 5, France E‐mail: ofdereure@wanadoo.fr Search for other works by this author on: Oxford Academic Google Scholar C. Biron, C. Biron Departments of Dermatology and Phlebology and *Haematological Diseases, and †Laboratory of Haematology, CHRU Montpellier, Hôpital Saint‐Eloi, 2 avenue Bertin Sens, 34265 Montpellier Cedex 5, France E‐mail: ofdereure@wanadoo.fr Search for other works by this author on: Oxford Academic Google Scholar J‐J. Guilhou J‐J. Guilhou Departments of Dermatology and Phlebology and *Haematological Diseases, and †Laboratory of Haematology, CHRU Montpellier, Hôpital Saint‐Eloi, 2 avenue Bertin Sens, 34265 Montpellier Cedex 5, France E‐mail: ofdereure@wanadoo.fr Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 142, Issue 4, 1 April 2000, Pages 834–836, https://doi.org/10.1046/j.1365-2133.2000.03449.x Published: 01 April 2000
Pain, Opioids, and Addiction
Authors: Mitchel L. Galishoff
Journal: Annals of Internal Medicine (2015)

Letters6 October 2015Pain, Opioids, and AddictionMitchel L. Galishoff, MDMitchel L. Galishoff, MDFrom Valley Medical & Surgical Clinic, Valley, Alabama.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5142 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I applaud Gregg (1) for her frank analysis of the problem of pain and addiction. However, I am concerned that the neurobiological explanation for chemical dependence and abuse has led to an errant conclusion about the patient's moral agency. I have attended 3 conferences last year wherein speakers instructed us to inform patients that their addiction "is not their fault."It is not logically necessary that a scientific explanation and moral responsibility be mutually exclusive. Both may be true and not violate the law of noncontradiction. Indeed, the diagnostic criteria for these disorders include behaviors that are ...Reference1. Gregg J. A startling injustice: pain, opioids, and addiction. Ann Intern Med. 2015;162:651-2. [PMID: 25938994] doi:10.7326/M14-1396 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Valley Medical & Surgical Clinic, Valley, Alabama.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L15-0356. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Startling Injustice: Pain, Opioids, and Addiction Jessica Gregg Pain, Opioids, and Addiction Jessica Gregg Pain, Opioids, and Addiction Jessica Gregg Metrics Cited byA Two-Year Prospective Multicenter Study of Opioid Therapy for Chronic Noncancer Pain: Prescription Trends and Predictors 6 October 2015Volume 163, Issue 7Page: 565KeywordsBehaviorConflicts of interestDisclosureForecastingOpioid addictionOpioids ePublished: 6 October 2015 Issue Published: 6 October 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Dysfunction of external respiration in patients with spinal tuberculosis
Authors: Zulfiya Nazirova, Alimardon Kuziev
Journal: European Respiratory Journal (2011)

Aim of the study was to determine the peculiarities of respiratory system dysfunctions and their effect on spinal tuberculosis clinical course.  We studied FER in 95 patients with spinal tuberculosis aged from 20 to 60 yr old to determine the peculiarities of dysfunctions.  Gravity of pulmonary breathing capacity dysfunctions was identified by abatement degree of VCL and MPBC: I degree – decrease in 16-35%; II degree - decrease in 36-55%; III degree – decrease more than 55%;  In 72 patients were revealed disturbances of FER indices. Of them, 19,5% patients had moderate embarrassment of ventilation, 45,8% -considerable, and 34,7% - full-blown. Thus, in 58 patients LVC was decreased in considerable and strong embarrassment of ventilation in 1,5-2 times as compared with normal one and only in 14 patients was followed moderate decline.  Study results established direct relation of LVC index decline from the size of spinal deformation. Therefore, LVC sharp decline was followed in patients with the maximum size of kyphosis (102,0±4,0), considerable - in moderate size of kyphosis (118,0±3,0). Normal indices and LVC moderate decline were noted in patients with minimum size of kyphosis (154,0±5,0). In 47 patients restrictive type of embarrassment of ventilation was observed. Combined type occurred in 14 patients, obstructive - in 11. Should be noted that despite LVC considerable and sharp decrease in most of examined patients, MPBC was rather in a lesser degree: in 17 patients outsized MPBC indices were determined, in 32 their moderate decline was noted.  Consequently, the presence of cerebrospinal dysfunctions depending on their depth and localization embarrass significantly the ventilation indices in patients with tuberculous spondylitis.
The evolution of modern psychiatric care in Nigeria
Authors: O A Erinosho
Journal: American Journal of Psychiatry (1979)

The author discussed the development of modern psychiatric care in Nigeria. There are two primary conceptual orientations among mental health workers in the country--the "non-culture bound" and the "culture-bound" approaches to mental health care. The effectiveness of modern psychiatric care in this society might well depend on the extent to which commonly accepted notions of mental illness are accommodated by professional care agents.
Forms of epithelial differentiation of draining sinus in acne inversa (hidradenitis suppurativa)
Authors: None Kurzen, None Jung, None Hartschuh, None Moll, None Franke, None Moll
Journal: British Journal of Dermatology (1999)

The draining sinus is a late complication of several forms of severe acne, leading to extensive, periodically inflamed lesions that are undermined by a system of fistulas, supposed to be of follicular origin. We investigated the expression of various cytokeratins (CKs) and desmosomal proteins in the draining sinus of acne inversa (hidradenitis suppurativa) using monoclonal antibodies in immunohistochemistry on paraffin‐embedded sections. We were able to define three different phenotypes of stratified squamous epithelia covering the sinus tracts. Type I epithelium was cornifying and characterized by the presence of CK 10, desmogleins 1–3 and desmocollins 1–3 in an epidermis‐like pattern. Type II epithelium was non‐cornifying, negative for CK 10 and positive for CK 13. It was negative for desmocollin 1 but strongly immunopositive for desmoglein 1 suprabasally and for desmoglein 2 in the basal cells. Type III epithelium was non‐cornifying and strongly inflamed. It was marked by the presence of CK 7, CK 19 and desmoglein 2 and the absence of CK 10, desmoglein 1 and desmocollin 1. In both type II and III epithelium, desmoglein 3, desmocollin 2 and desmocollin 3 showed an inverted staining pattern as compared with normal epidermis and type I epithelium. Desmoglein 2 and CK 5/14 always remained restricted to the basal cell layer. Antibodies against CK 6 and CK 13/15/16 were immunopositive in all three phenotypes and CK 17 was predominantly immunolocalized to suprabasal layers of type II and III epithelium. The three phenotypes are characterized as pathological stratified squamous epithelia reflecting the dynamic process of inflammation, proliferation and stratification taking place in acne inversa.
Adverse reactions during treatment of multidrug-resistant and extensively drug-resistant tuberculosis
Authors: Susana Boavida, Inês Sanches, Ana Antunes, Sérgio Campainha, Ana Horta, Ana Maria Correia, Anabela Silva, Raquel Duarte
Journal: European Respiratory Journal (2012)

Introduction  Treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively resistant tuberculosis (XDR-TB) is often complicated by adverse reactions.   Objectives:  To describe the adverse reactions, time of occurrence, attitudes and risk factors among MDR/XDR-TB patients.   Methods:  Retrospective cohort of all patients with MDR/XDR-TB evaluated at the Regional Referral Center for MDR/XDR-TB in northern Portugal from July 2009 until January 2012.   Results  We analyzed 29 patients, 19 (65.5%) men, mean age 48 years. Eighteen (62.1%) had co-morbidities of which HIV infection was the most frequent (8 patients). Twenty-two patients (75.9 %) had adverse reactions and 17 (77.3%) had to suspend the drug involved. Median time to occurrence of adverse reactions was 94 days (min=2, max=619). Toxicity related to the injectable drug was the most frequent - 9 (31%) with ototoxicity, and 7 (24.1%) with renal insufficiency. Hypothyroidism was present in 6 (20.7%) of the patients. Psychiatric disorders, associated to cicloserine occurred in 6 (20.7%) patients. Multivariate analysis could not identify independent risk factors in relation to adverse reactions. The occurrence of adverse reactions was not associated with a higher risk of dead or a worse outcome.   Conclusions  The occurrence of adverse reactions more often correlated with the injectable drug and occurred around the third month. We could not identify independent risk factors for adverse reactions and they did not affect the outcome.
Outcome study of patient (pts) with localized prostate cancer (PC) staged by reverse transcription quantitative real-time-PCR (QRT-PCR) analysis of prostate specific antigen (PSA) mRNA levels in pathologically normal (NO) pelvic lymph nodes (PLN)
Authors: A. C. Ferrari, N. Stone, R. Kurek, E. Mulligan, R. Stock, P. D. Unger, S. Hall, A. V. Kaisary, R. E. Gallagher, J. P. Mandeli
Journal: Journal of Clinical Oncology (2004)

4583 Background: PC recurs in 1/3 of pts after local treatment indicating micrometastases are frequently undetected. Based on established risk factors (RF) for recurrence - tumor stage (T), serum PSA (sPSA) and biopsy Gleason score (GL), pts are stratified in low (T≤2A + PSA<10 ng/ml + GL<7); intermediate (T2B or PSA10–20 or GL=7) or high (T≥2C or PSA>20 or GL>7) risk. Although helpful, quantification of PSA mRNA in high-risk N0 PLN pts might identify those with prognostically-relevant tumor loads of metastases whose potential benefit from early systemic therapy would override its morbidity. Methods: Bilateral N0 PLN of 341 PC pts undergoing radical prostatectomy (RP) or radiation (XRT) were prospectively collected with baseline data and sPSA follow-up (f/u). In 318 cases, PSA mRNA copies were quantified by QRT-PCR. Duplicate test samples were adjusted to a fixed housekeeping gene transcript level that minimized false positives. We assessed whether a threshold PSA copy number (tPSA) was associated with progression free survival (PFS), as well as with RF. PSA failure was defined as a rise ≥0.2 after RP or by the first of three rises after XRT. Results: 70 (21%) pts had 0 PSA copies, 175 (51%) >0–50, 20 (6%) >50–100, 53 (16%) >100; 23 (7%) were inadequate. At 4 years median f/u, a significant correlation emerged for tPSA copies ≥100 vs <100 and PFS, plus interactions with sPSA >10, GL >7 and high-risk group (Table). By Cox regression analysis relative risk for PSA ≥100 copies (95% CI) was 2.18 (1.18–4.01) after adjusting for categorical RF and 1.98 (1.06–3.69) for continuous RF. Conclusions: PSA QRT-PCR ≥100 defined an occult tumor burden level in N0 PLN of independent prognostic value overall and is especially predictive of recurrence at 4 years in high-risk pts. No significant financial relationships to disclose.
Risk factors for 30-day mortality in patients with pneumonia who receive appropriate initial antibiotics: an observational cohort study
Authors: Yuichiro Shindo, Ryota Ito, Daisuke Kobayashi, Masahiko Ando, Motoshi Ichikawa, Yasuhiro Goto, Yasutaka Fukui, Mai Iwaki, Junya Okumura, Ikuo Yamaguchi, Tetsuya Yagi, Yoshimasa Tanikawa, Yasuteru Sugino, Joe Shindoh, Tomohiko Ogasawara, Fumio Nomura, Hideo Saka, Masashi Yamamoto, Hiroyuki Taniguchi, Ryujiro Suzuki, Hiroshi Saito, Takashi Kawamura, Yoshinori Hasegawa
Journal: The Lancet Infectious Diseases (2015)
CXCR4-targeted lipid-coated PLGA nanoparticles deliver sorafenib and overcome acquired drug resistance in liver cancer
Authors: Dong-Yu Gao, Ts-Ting Lin, Yun-Chieh Sung, Ya Chi Liu, Wen-Hsuan Chiang, Chih-Chun Chang, Jia-Yu Liu, Yunching Chen
Journal: Biomaterials (2015)
Epidermal growth factor receptor mutation status in advanced non-small cell lung cancer: A single institution experience
Authors: Neringa Vaguliene, Marius Zemaitis, Valdas Sarauskas, Astra Vitkauskiene, Skaidrius Miliauskas, Raimundas Sakalauskas
Journal: European Respiratory Journal (2012)

Background: Epidermal Growth Factor Receptor (EGFR) mutations are found in 10-20% of non-small cell lung cancer (NSCLC) and are associated with response to EGFR tyrosine kinase inhibitors (TKIs). The aim of this study is to examine the prevalence of EGFR mutations among patients with advanced non-squamous NSCLC treated in our institution and evaluate the associations of EGFR mutations with clinicopathological characteristics.  Methods: We examined the EGFR mutations in exons 19 and 21 using sequence analysis of 133 patients with NSCLC from April 2010 till February 2012. Patients harboring EGFR mutations were treated with EGFR-TKIs, patients EGFR negative - with standart chemotherapy. 54 patients with advanced NSCLC who were not tested for EGFR mutations treated with standart chemotherapy were considered as the control group.  Results: EGFR mutations were found in 18 patients (13.5%): female 30.3% (10/33), male 8.0% (8/100) (P 0.05). Overall response rate was 85.7% in EGFR mutation positive, 32.9% in EGFR mutation negative and 31.5% in control groups (P  Conclusions: The frequency of EGFR mutations is similar that presented in Europe. Screening of patients with NSCLC for EGFR mutations have a role in treatment decisions.
Longitudinal study of pulmonary function tests in students of Shalamar Medical and Dental College Lahore Pakistan
Authors: Rais Nawaz, Saghir Ahmed, Farida Munawar, Saleem Uz Zaman
Journal: European Respiratory Journal (2013)

Background : A research was conducted on students of 1 st  year, Shalamar Medical and Dental college in 2010 using Students’ Wet Spirometer, aimed at observing the difference in predicted and recorded vital capacity in young Pakistani adults. In December 2012, the study was done to identify some factors that affect the growth and development of lung functions in young medical students of same batch belonging to age group 19-25 years, using Spirolab III version 3.4. Vital capacity and forced expiratory Spirograms were obtained in a cohort of young males (n=30) and females (n=46) at intervals of approximately 2 years. Factors that affected the normal pattern of lung function development in this group were smoking, obesity and exercise.FEV1/VC and FEV1/FVC ratios were calculated and found altered in both groups, i.e those who were smoking and those who smoked and were exercising.  Results:  There was significant difference in FEV1/VC and FEV1/FVC ratio at (p CONCLUSION:  It is concluded that in relatively healthy group of young adults most measures of respiratory function reach optimum values at 19 or 20 years of age and change little if healthy living habits are continuously adopted.It was advised to students to quit smoking, do regular exercise and avoid obesity.
Endotracheal pressure during nasal high flow in patients after long-term mechanical ventilation
Authors: Karl-Josef Franke, Karl-Heinz Ruhle, Ulrike Domanski, Maik Schroeder, Sheng Feng, Stanislav Tatkov, Georg Nilius
Journal: European Respiratory Journal (2014)

Rationale Nasal high flow (NHF) is a novel form of respiratory support in patients with respiratory failure. A possible mechanism is that of heightening the positive end-expiratory pressure (PEEP) and thereby improving alveolar ventilation. Methods In 10 tracheotomised and decannulated patients the tracheostomy retainer was capped and warm airflow was delivered at the nose (AIRVO2, Fisher & Paykel, NZ) at flow rates of 0, 15, 30 and 45 L/min. The tracheal cap was custom-built allowing to measure endotracheal pressure. Tidal volume (VT) was monitored via respiratory inductance plethysmography. The main outcome parameter was the endotracheal PEEP in response to NHF at defined flow rates. Results At flow rates of 0, 15, 30 and 45 L/min, the endotracheal PEEP increased nearly linear from 0.41±0.47 to 0.90±0.68, 1.52±1.14 and 2.28±2.05 cmH2O. The peak expiratory pressure (PEP) increased in a similar way, probably as a result of counter-moving flows (patients expiratory flow and NHF), while the peak inspiratory flow (PIP) only increased at a flow rate of 45 L/min (figure1). VT remained constant at a flow rate of 15 L/min compared to baseline (0.39±0.19 vs. 0.39±0.19 L), and increased at flow rates of 30 and 45 L/min (0.43±0.25; 0.46±0.22 L).

![Figure][1] 



Conclusions NHF creates an endotracheal PEEP, which amounts to 2.28±2.05 cmH2O at a flow rate of 45 L/min. The clinical benefit of creating low PEEPs should further be investigated.

 [1]: pending:yes
Neurasthenia and chronic fatigue syndrome: the role of culture in the making of a diagnosis
Authors: S E Abbey, P E Garfinkel
Journal: American Journal of Psychiatry (1991)

Chronic fatigue syndrome is an increasingly popular diagnosis consisting of multiple psychiatric and somatic symptoms. It bears a striking resemblance to the nineteenth-century diagnosis of neurasthenia. Both disorders arose during periods characterized by a preoccupation with commerce and material success and major changes in the role of women. They illustrate the role of culture in the development of a new diagnosis that emphasizes a "medical" rather than "psychiatric" etiology. The authors argue that chronic fatigue syndrome will meet the same fate as neurasthenia--a decline in social value as it is demonstrated that the majority of its sufferers are experiencing primary psychiatric disorders or psychophysiological reactions and that the disorder is often a culturally sanctioned form of illness behavior.
Stresses on women doctors may cause higher suicide risk
Authors: Roger Dobson
Journal: BMJ (2001)

Suicide rates among women NHS doctors in the United Kingdom are twice that of the general female population, new research has found. It also found differences in suicide rates between medical specialties, with anaesthetists, community health doctors, GPs, and psychiatrists of both sexes having significantly higher rates than doctors in general hospital medicine.

Researchers say that the high risk in women …
Abstract 17055: A New Cohort Confirms the High Prevalence and Severity of Endothelial and Microvascular Dysfunction Among Women with Symptoms of Ischemia and No Obstructive Coronary Artery Disease: the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE)
Authors: R. David Anderson, John W Petersen, Puja K Mehta, Janet Wei, B. Delia Johnson, Eileen M Handberg, Saibal Kar, Bruce Samuels, Babak Azarbal, Kamlesh Kothawade, Sheryl F Kelsey, Barry Sharaf, Leslee J Shaw, C. Noel Bairey-Merz, Carl J Pepine
Journal: Circulation (2011)

Background: Previous evaluations in women studied in 1997-2001 with symptoms/signs of ischemia without obstructive coronary artery disease demonstrated a relatively high prevalence of both endothelial and microvascular dysfunction: these abnormalities were then shown to predict adverse events in follow-up. Coronary reactivity testing (CRT) with flow reserve (CFR &lt;2.5), vasoconstriction to acetycholine (ACH), or &lt;20% vasodilation to nitroglycerin (NTG) were taken as abnormal responses. To our knowledge, the prevalence of these disorders has not been reassessed in a more contemporary population of women. Methods: Accordingly, we studied a contemporary (2009-2011) WISE cohort with symptoms/signs of ischemia but without obstructive CAD undergoing CRT and compared their findings to those from the original WISE cohort. Following demonstration of no obstructive CAD, defined as &lt;50% epicardial stenosis in any coronary artery, patients underwent CRT. Using a Doppler transducer-tipped guide wire (Volcano ®FloWire 300cm) in a left coronary artery, CFR was measured after intracoronary (IC) adenosine, followed by sequentially IC ACH and IC NTG with quantitative angiography and Doppler flow measurement evaluated by core labs. Results: Among the 94 women who underwent CRT, the mean age was 53 (23-73 years), 37% were non-Caucasian. Of these 33% had hypertension, 41% hyperlipidemia, 6% diabetes, 18% used hormone replacement, and 49% had a history of smoking. Coronary reactivity data for the two cohorts is shown in the Table. Conclusion: Compared with our prior WISE cohort of women with signs and symptoms of ischemia but without obstructive CAD, both endothelial and microvascular dysfunction remain highly prevalent and similar in degree in a contemporary cohort. Because these abnormalities have been linked to prediction of major adverse cardiac events, clinical trials targeting these pathways appear to be indicated.
Call for a review of services for people with neurological disorders
Authors: Geraint Fuller, Phil Smith, Mary Reilly, Ralph Gregory
Journal: BMJ (2015)

Morrish highlights that the UK has too few neurologists, an inadequate provision of neurology services,1 and the enormous variations in access to acute neurological services we identified in our recent survey2—a far cry from our aspiration of a seven day service across the country. This limited and patchy access …