HEREDITARY HEMORRHAGIC TELANGIECTASIA: REPORT OF TWO CASES
Authors: Glenn Q. Voyles, James O. Ritchey
Journal: Annals of Internal Medicine (1945)

Case Reports1 May 1945HEREDITARY HEMORRHAGIC TELANGIECTASIA: REPORT OF TWO CASESGLENN Q. VOYLES, M.D., JAMES O. RITCHEY, M.D., F.A.C.P.GLENN Q. VOYLES, M.D.Search for more papers by this author, JAMES O. RITCHEY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-22-5-730 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHereditary hemorrhagic telangiectasia is a rare disease, first recognized by Osler,10 and is characterized by the triad of multiple telangiectases; hemorrhage, or anemia; and a history of familial occurrence. Some 500 cases occurring in over 100 families have been described.6The characteristic lesions consist of pin-point to pea-sized telangiectases occurring most commonly in the skin and mucous membranes, but have also been described in almost every organ-system in the body—gastrointestinal tract, genito-urinary system, respiratory system, and brain. These telangiectases represent dilatation of the blood vessel walls which consist of a single layer of endothelium covered with a much thinned layer...Bibliography1. BLUM V: Familiäre essentialle Hämaturia. Beitrag zur Frage der Oslerschen Krankhiet, Med. Klin., 1936, xxxii, 1254-1255. Google Scholar2. BOSTON LP: Gastric hemorrhage due to familial telangiectasis, Am. Jr. Med. Sci., 1930, clxxx, 798-802. CrossrefGoogle Scholar3. FITZHUGH T: The importance of atavism in the diagnosis of hereditary hemorrhagic telangiectasis, Am. Jr. Med. Sci., 1923, clxvi, 884-893. CrossrefGoogle Scholar4. FITZHUGH T: Splenomegaly and hepatic enlargement in hereditary hemorrhagic telangiectasis, Ibid., 1932, clxxxi, 261-268. Google Scholar5. FOGGIE WE: Hereditary hemorrhagic telangiectasis with recurring hematuria, Edinburgh Med. Jr., 1928, xxxv, 282-290. Google Scholar6. GOLDSTEIN HI: Hereditary multiple telangiectasis, Arch. Dermat. and Syph., 1932, xxvi, 282-308. CrossrefGoogle Scholar7. GOLDSTEIN HI: Unusual gastrorrhagia or hematemesis: hereditary hemorrhagic telangiectatic Dysplasia with stomachorrhagia or gastrorrhagia, Am. Jr. Digest. Dis., 1938, v, 115-116. CrossrefGoogle Scholar8. GRIGGSBAKER DEMQ: Hereditary hemorrhagic telangiectasis with gastrointestinal bleeding, Am. Jr. Digest Dis., 1941, viii, 344-347. CrossrefGoogle Scholar9. KELLER W: Zur Kasuistik der Hämaturie in Kindesalter, Monatsschr. f. Kinderh., 1939, lxxix, 376-381. Google Scholar10. OSLER W: Family form of recurring epistaxis, associated with multiple telangiectases of skin and mucous membrane, Bull. Johns Hopkins Hosp., 1901, xii, 333-337. Google Scholar11. RENSHAW JF: Multiple hemorrhagic telangiectasis with special reference to gastroscopic appearance (of stomach mucosa), Cleveland Clinic Quart., 1939, vii, 226-230. CrossrefGoogle Scholar12. STELLAR LI: Hereditary telangiectasis: Case, New England Jr. Med., 1942, ccxxvi, 336-338. CrossrefGoogle Scholar13. TEAHAN WW: Hereditary telangiectasis occurring in 6 generations, Ann. Int. Med., 1939, xiii, 535-543. Google Scholar14. WILLIAMSSNELL DHAM: Pulsating angioma (generalized telangiectasia) of skin associated with hepatic disease, Arch. Int. Med., 1938, lxii, 872-882. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Indianapolis, Indiana*Received for publication December 6, 1943.From the Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHereditary hemorrhagic telangiectasisSevere Hematuria With Associated Minute Papilloma of Renal Pelvis: Case ReportHEREDITARY HAEMORRHAGIC TELANGIECTASIA: A GENETIC AND BIBLIOGRAPHICAL STUDY.Blood dyscrasia in otolaryngology 1 May 1945Volume 22, Issue 5Page: 730-736KeywordsAnemiaBlood vesselsBrainEndotheliumGenetic diseasesHemorrhageLesionsMucous membranesRespiratory system ePublished: 1 December 2008 Issue Published: 1 May 1945 PDF downloadLoading ...