tbuckley/cabot-search huggingface dataset:
Abstract P322: Soda Consumption is Associated With Carotid Intima-Media Thickness Among Middle-Aged Mexican Women
Authors: Mariel Arvizu, Adriana Monge, Martha Thamez, Eduardo Ortiz-Panozo, Elsa Yunes, Andres Catzín-Kuhlmann, Carlos Cantu-Brito, Ruy López-Ridaura, Martin Lajous
Journal: Circulation (2015)

Introduction: Soda intake is associated with cardiovascular disease. Other sweetened drinks often considered healthy alternatives to sodas could have a similar impact on cardiovascular risk. Hypothesis: Sugar-sweetened beverages commonly consumed by Hispanics have a negative influence on cardiovascular risk. Methods: We evaluated the cross-sectional relationship of sweetened beverages and common carotid intima-media thickness (CIMT) in 1,054 disease-free women without diabetes, high cholesterol, history of stroke and/or myocardial infarction, from the Mexican Teachers’ Cohort. Beverage intake was estimated from a validated food-frequency questionnaire in 2008 and 4 years later, CIMT measurements were performed by neurologists. We defined subclinical atherosclerosis as CIMT ≥0.8mm or presence of plaque and beverage intake was categorized in quartiles of servings/day. Results: Mean (±SD) soda intake was 0.5 ± 0.7 servings/day among 45.2 ± 4.7 year old women and atherosclerosis prevalence was 8.7%. After adjusting for age, smoking, secondhand smoke, physical activity, oral contraception, menopausal status, SES, and diet, % change of CIMT per 1 serving/day of soda was 1.3 (95% CI 0.2-2.3). Comparing extreme quartiles of soda intake, we observed a 3.5% (95% CI 1.1-5.8; p-trend=0.003) increase in CIMT (Figure). Intake of artificially-sweetened soda, fruit infused water, and juice was not associated to CIMT. None of the beverages were associated to subclinical atherosclerosis. Conclusions: In this cross-sectional study, soda intake was associated to increased CIMT while artificially-sweetened soda, fruit water, or juice intakes were not. Our results support prior results on the adverse consequences of soda intake in cardiovascular health. Keywords: sugar-sweetened beverages, cardiovascular risk, intima media thickness, cross-sectional
Global warming threatens reversal in fight against poverty, says report
Authors: Rhona MacDonald
Journal: BMJ (2004)

“Today, humanity faces the intertwined challenges of obscene levels of poverty and a rapidly warming global climate,” states a new report, Up in Smoke, a collaborative effort involving many leading international charities and published last week by the New Economics Foundation, an independent, UK based think tank.

The report warns: “Globally several environmental, economic and political trends are coinciding and contributing to rising instability that exposes people and biodiversity to greater risks and vulnerability than ever before.”

Most of the people at risk are in poor countries. The cumulative number of people affected by disasters rose to two billion in the 1990s, up from 740 million in the …
Küçük Hücreli Dışı Akciğer Kanserinde Primer Tümörde ve Metastaz Yerlerinde Epidermal Büyüme Faktörü Reseptör Geni
Authors: Lorenzo Daniele, Paola Cassoni, Elisa Bacillo, Susanna Cappia, Luisella Righi, Marco Volante, Fabrizio Tondat, Giorgio Inghirami, Anna Sapino, Giorgio V. Scagliotti, Mauro Papotti, Silvia Novello
Journal: Journal of Thoracic Oncology (2009)
α&lt;sub&gt;1&lt;/sub&gt;-Proteinase Inhibitor Production by Human Adenocarcinomas Xenotransplanted Into Nude Mice&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Authors: D Lee, D Shochat, D V Gold
Journal: JNCI Journal of the National Cancer Institute (1982)

Human colon adenocarcinomas xenotransplanted into BALB/c nude mice were examined for the ectopic synthesis of alpha 1-proteinase inhibitor(s) (alpha 1Pi). Tumor extracts were prepared by homogenization followed by molecular sieve chromatography on Sepharose 4B. Fractions with immunoreactive alpha 1Pi were concentrated and adsorbed onto a concanavalin A-Sepharose 4B affinity column, then eluted, concentrated, and analyzed. All 4 colon tumors examined produced alpha 1Pi with full antigenic identity to normal human plasma alpha 1Pi. Electrophoretic mobilities of 3 of the tumor-derived alpha 1Pi were different from the electrophoretic mobility of the normal human plasma alpha 1Pi. Activities of the inhibitors were determined by the reaction of each tumor extract with pancreatic elastase (PE) followed by immunoelectrophoresis of the reaction mixture against both anti-human alpha 1Pi and anti-PE antisera. Two of the tumor-derived alpha 1Pi examined were active in inhibiting PE.
The 2009-2010 H1N1 vaccination campaign for patients with egg allergy in a region of France
Authors: A. Siret-Alatrista, F. Bouali, M. Demoly, P. J. Bousquet, P. Demoly
Journal: Allergy (2010)

We describe our experience of the influenza H1N1 vaccination in patients with egg allergy. All patients tolerated the vaccination in a simple or double dose protocol without any significant allergic reaction in this series.
Abstract 14669: Predictive Value of Lesion-Associated Parameters from Coronary Computed Tomography Angiography for Hemodynamically Significant Stenoses Confirmed by Invasive Fractional Flow Reserve
Authors: Matthias Renker, Rui Wang, Felix G Meinel, Stefan Baumann, Jeremy D Rier, Richard R Bayer, Holger Nef, Christian W Hamm, Daniel H Steinberg, U J Schoepf
Journal: Circulation (2014)

Background: The ability of coronary computed tomography angiography (cCTA) to gauge lesion-specific ischemia is limited. Recent studies proposed several parameters, such as morphologic indices (lesion length/minimal lumen diameter4, LL/MLD4; aggregate plaque volume, %APV) and measures of intracoronary contrast gradients (transluminal attenuation gradient, TAG; corrected contrast opacification, CCO), to mitigate this limitation. We aimed at evaluating and comparing parameters derived from routine cCTA for gauging the hemodynamic significance of stenosis, using fractional flow reserve (FFR) as the reference standard.

Methods and Results: Forty-nine patients who had undergone cCTA and invasive angiography with FFR within 3 months were included. An experienced observer visually assessed all cCTA studies and derived LL/MLD4, %APV, TAG, CCO and other measures characterizing the lesion of interest, including LL, MLD, minimal lumen area (MLA), diameter stenosis (%DS), area stenosis (%AS), and remodeling index. Lesion-specific ischemia was considered with FFR <0.8. Among 56 lesions, 13 were significant by FFR. On univariate analysis, LL, MLD, %DS, LL/MLD4, TAG, and CCO showed discriminatory power regarding lesion-specific ischemia. The area under the receiver operating characteristics curve (AUC) was significantly greater for LL/MLD4 (0.91) compared with MLD (0.80, p=0.01), TAG (0.75, p=0.03), %DS (0.75, p=0.04), LL (0.74, p=0.04), and CCO (0.81), although the latter did not reach statistical significance (p=0.18). On multivariate regression, LL/MLD4 was the only independent predictor of lesion specific ischemia (odds ratio 2.02, p=0.01). Also, LL/MLD4 compared favorably to visual cCTA assessment (Figure 1).

Conclusions: Our data suggest that LL/MLD4 derived from routine cCTA can enhance the diagnostic performance for detecting lesion-specific ischemia and provides incremental value over other described parameters.

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Maternal Urinary Bisphenol A during Pregnancy and Maternal and Neonatal Thyroid Function in the CHAMACOS Study
Authors: Jonathan Chevrier, Robert B. Gunier, Asa Bradman, Nina T. Holland, Antonia M. Calafat, Brenda Eskenazi, Kim G. Harley
Journal: Environmental Health Perspectives (2012)

Background: Bisphenol A (BPA) is widely used in the manufacture of polycarbonate plastic bottles, food and beverage can linings, thermal receipts, and dental sealants. Animal and human studies suggest that BPA may disrupt thyroid function. Although thyroid hormones play a determinant role in human growth and brain development, no studies have investigated relations between BPA exposure and thyroid function in pregnant women or neonates.Objective: Our goal was to evaluate whether exposure to BPA during pregnancy is related to thyroid hormone levels in pregnant women and neonates.Methods: We measured BPA concentration in urine samples collected during the first and second half of pregnancy in 476 women participating in the CHAMACOS (Center for the Health Assessment of Mothers and Children of Salinas) study. We also measured free thyroxine (T4), total T4, and thyroid-stimulating hormone (TSH) in women during pregnancy, and TSH in neonates.Results: Associations between the average of the two BPA measurements and maternal thyroid hormone levels were not statistically significant. Of the two BPA measurements, only the one taken closest in time to the TH measurement was significantly associated with a reduction in total T4 (β = –0.13 µg/dL per log2 unit; 95% CI: –0.25, 0.00). The average of the maternal BPA concentrations was associated with reduced TSH in boys (–9.9% per log2 unit; 95% CI: –15.9%, –3.5%) but not in girls. Among boys, the relation was stronger when BPA was measured in the third trimester of pregnancy and decreased with time between BPA and TH measurements.Conclusion: Results suggest that exposure to BPA during pregnancy is related to reduced total T4 in pregnant women and decreased TSH in male neonates. Findings may have implications for fetal and neonatal development.
Third generation oral contraceptives
Authors: D. C G Skegg
Journal: BMJ (2000)

Oral contraception is effective, convenient, and reversible. For most women it is also remarkably safe. Some people involved in family planning go further and imply that the oral contraceptive pill is almost free of risk. This creates an illusion that is shattered whenever adverse effects—however rare—are brought to light. In October 1995 the Committee on Safety of Medicines in the United Kingdom warned that oral contraceptives containing desogestrel or gestodene carried a small increase in risk of venous thromboembolism compared with older preparations. The chaos that followed in Britain (and a few other countries) may have stemmed partly from an illusion of absolute safety, as well as from the publicity triggered by the warning.

The committee's announcement was followed by the publication of four well designed studies that gave a consistent picture: women using third generation oral contraceptives containing desogestrel or gestodene had about twice the risk of venous thromboembolism of women using preparations containing levonorgestrel.1 In the four years that have followed, a plethora of articles, reviews, and symposiums have implied that these reports were flawed and that reanalyses or new studies show no differences in the risk of …
Abstract 20019: Tumor Necrosis Factor Alpha Inducible Protein Like 1 Promotes Angiogenesis by Inhibition of Endothelial Cell Apoptosis
Authors: Dennie Tempel, Petra Burgisser, Caroline Cheng, Gerard Pasterkamp, Henricus Duckers
Journal: Circulation (2014)

During the initial phase of angiogenesis, proliferating endothelial cells (ECs) are highly susceptible to apoptosis and need rescuing by biological anti-apoptotic cues to ensure survival of the neovasculature. Although the molecular mechanisms that govern the formation of a vascular network have been studied intensively, specific angiogenic factors that regulate EC apoptosis still need to be further identified. Using a transcriptomics approach to identify new regulators of angiogenesis, we identified tumor necrosis factor alpha inducible protein like 1 (TNFaip8L1), a gene of hitherto unknown function that was highly expressed in ECs. During mouse and zebrafish development, TNFaip8L1 expression was predominantly restricted to angioblasts and adult ECs. In vitro, overexpression of TNFaip8L1 using a lentivirus enhanced the endothelial capacity to form tubes (P<0.05, n=6) in HUVECs. In vivo in the murine retina, TNFaip8L1 overexpression resulted in enhanced formation of the vascular network (P<0.05, n=10). Th...
A Short History of Some Common Diseases
Authors: W. R. Bett
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 12417: Left Ventricular Assist Device Reimplantation for Recurrent Heart Failure After Myocardial Recovery and Weaning
Authors: Tomohiro Saito, Michael Dandel, Yuguo Weng, Evgenij Potapov, Thomas Krabatsch, Roland Hetzer
Journal: Circulation (2014)

Object: In our experience, 5-10% of patients with dilative cardiomyopathy have presented myocardial recovery and could be weaned from long-term support with left ventricular assist device (LVAD). However, one third of them had a heart failure recurrence during follow-up. Subsequent treatment options are limited to heart transplantation or reimplantation of LVAD. We evaluated clinical outcome of the patients treated with LVAD reimplantation. Methods: Between 1995 and 2014, 64 patients implanted with LVAD for dilative cardiomyopathy (median age 43, range 16-71 years) were weaned from LVAD according to our institutional protocol. Among them, six patients required later reimplantation of LVAD due to recurrent heart failure. Hospital records were retrospectively reviewed. Results: LVAD reimplantation in the six patients was necessary at a median of 1638 (range, 393-5336) days after weaning from the first LVAD. Actual median duration of freedom from heart failure recurrence (from date of weaning from first LVAD...
Abstract 19258: Cytoprotective Effect of Growth Hormone Releasing Hormone Agonists in Cardiac Stem Cells
Authors: Victoria Florea, Sonia S Majid, Rosemeire M Kanashiro-Takeuchi, Norman L Block, Andrew V Schally, Joshua M Hare, Claudia O Rodrigues
Journal: Circulation (2014)

Introduction and hypothesis:  Our group has previously shown that agonists of growth hormone releasing hormone receptor (GHRHR) improve cardiac performance in heart failure models and reverse remodeling. This effect was associated with an increase in the number of c-kit+ cardiac stem cells (CSC), suggesting that this agonist might have an effect on these cells.   Methods and Results:  We investigated the expression of GHRHR in CSC of different species by flow cytometry analysis. GHRH-R is expressed in 96-98% of CSC isolated from mouse, rat and pig. Results were compared to GHRHR expression in HeLa (positive control) and MCF7 and T47D cell lines (negative control). To determine if GHRHR activation can improve CSC self-renewal, we tested the effect of GHRH agonists on porcine CSC proliferation. The rate of cell division was increased 2-fold with JI38 (GHRHR agonist) treatment (3.4 ± 0.7) vs. vehicle control (1.7 ± 0.2) (p   Conclusion:  These findings show for the first time the expression of GHRHR in CSC. GHRHR agonists promote CSC proliferation and enhance survival. GHRHR-A effects on CSC proliferation are mediated through activation of ERK, PI3K and AKT pathways. Activation of GHRHR signaling pathways represents a novel therapeutic approach to protect and stimulate endogenous CSC population thus promoting cardiac repair.
Mental health services for people with learning disabilities
Authors: A. Hassiotis
Journal: BMJ (2000)

Mental health services in the United Kingdom are set for dramatic restructuring in the light of recent government initiatives to improve quality of care and equity of provision. National standards for promoting mental health and treating mental illness are designed to reduce the risk of future tragedies and improve the quality of life of people with mental illness.1 But little thought has been given to the well documented mental health needs of people with learning disabilities.

In the age of institutional care the disturbed and challenging behaviour of people with learning disabilities was thought to be due to their living environment and their learning disability. Their care was greatly influenced by humanistic and philosophical ideas.2 The widespread closure of “long stay” hospitals for people with learning disabilities was accompanied by …
Non-caloric artificial sweeteners and the microbiome: findings and challenges
Authors: Jotham Suez, Tal Korem, Gili Zilberman-Schapira, Eran Segal, Eran Elinav
Journal: Gut Microbes (2015)

Non-caloric artificial sweeteners (NAS) are common food supplements consumed by millions worldwide as means of combating weight gain and diabetes, by retaining sweet taste without increasing caloric intake. While they are considered safe, there is increasing controversy regarding their potential ability to promote metabolic derangements in some humans. We recently demonstrated that NAS consumption could induce glucose intolerance in mice and distinct human subsets, by functionally altering the gut microbiome. In this commentary, we discuss these findings in the context of previous and recent works demonstrating the effects of NAS on host health and the microbiome, and the challenges and open questions that need to be addressed in understanding the effects of NAS consumption on human health.
EQUINE INFECTIOUS ANEMIA TRANSMITTED TO MAN
Authors: Johan T. Peters
Journal: Annals of Internal Medicine (1945)

Case Reports1 August 1945EQUINE INFECTIOUS ANEMIA TRANSMITTED TO MANJOHAN T. PETERS, M.D.JOHAN T. PETERS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-2-271 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn his recent book, titled "Diseases Transmitted from Animals to Man" (1941), Thomas Hull1writes: . . . "equine infectious anemia has never been known to infect man." The purpose of this report is to demonstrate that this statement is no longer valid. It is not difficult to recognize this virus disease if the possibility of its occurrence be remembered. It may be expected that other cases will soon be discovered among patients with aplastic anemia of unknown origin if the method of examination described in this article be applied. This expectation is based on the following facts:a. There...Bibliography1. HULL TG: Diseases transmitted from animals to man, 2d ed., 1941, Thomas. Google Scholar2. HAGAN WA: Infectious diseases of domestic animals with special reference to etiology, diagnosis and biologic therapy, 1943, Comstock. Google Scholar3. DOWNEY H: Handbook of hematology, 1938, Hoeber, vol. 3, p. 2171. Google Scholar4. VALLÉECARRÉ : Sur la nature infectieuse de l'anémie du cheval, Compt. rend. Acad. d. sci., 1904, cxxxix, 331-333. Google Scholar5. SCHALKRODERICK AFLM: The history of swamp fever virus carrier, South Dakota Agric. Exper. Station Bull. 168, Agric. College. North Dakota, 1923. Google Scholar6. RUNNELLS RA: Animal pathology, 2d ed. 1941, Iowa State College Press. Google Scholar7. STEINOSTEINMOLTSTAHAN CDOLLOMS: Action of chemical and physical agents on the virus of equine infectious anemia, Am. Jr. Vet. Res., 1944, v, 291. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Louisiana State University New Orleans, Louisiana*Received for publication January 10, 1944. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byApplication of Marrow Grafts in Human Disease: Its Problems and PotentialMenschliche Infektionen durch tierpathogene VirenDie Panmyelophthise und verwandte Zustände der KnochenmarksinsuffizienzViral Infections Contracted in the Laboratory 1 August 1945Volume 23, Issue 2Page: 271-274KeywordsAnemiaAplastic anemiaMotivation ePublished: 1 December 2008 Issue Published: 1 August 1945 PDF downloadLoading ...
Evaluation of the safety, recovery, half-life, and clinical efficacy of antithrombin III (human) in patients with hereditary antithrombin III deficiency. Cooperative Study Group [see comments]
Authors: D Menache, JP O'Malley, JB Schorr, B Wagner, C Williams, BM Alving, JO Ballard, SH Goodnight, WE Hathaway, MB Hultin
Journal: Blood (1990)
Erratum: Corrigendum: Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma
Authors: Lawrence N Kwong, James C Costello, Huiyun Liu, Shan Jiang, Timothy L Helms, Aliete E Langsdorf, David Jakubosky, Giannicola Genovese, Florian L Muller, Joseph H Jeong, Ryan P Bender, Gerald C Chu, Keith T Flaherty, Jennifer A Wargo, James J Collins, Lynda Chin
Journal: Nature Medicine (2012)
Abstract 1663: CD40 agonists drive the anti-tumor functions of macrophages and induce systemic immune activation survival the Pan02 orthotopic pancreatic model
Authors: Nadia Luheshi, James Harper, Jane Coates-Ulrichsen, Richard Sainson, Robert W. Wilkinson, Gareth Davies, James William Legg
Journal: Cancer Research (2014)

Abstract Pancreatic cancer represents an area of high unmet medical need. Antibodies agonising CD40 (αCD40) inhibit tumor growth in preclinical models, and are showing activity in early clinical trials in pancreatic cancer. αCD40 antibodies can directly drive apoptosis and promote antibody-dependent cell cytotoxicity of CD40 positive tumor cells, and may also drive antitumor effects through endothelial cells and B cells. However, data from preclinical models indicate that a major mechanism of action for αCD40 antibodies is through targeting of macrophages and dendritic cells, in some cases promoting long term CD8 T cell-dependent anti-tumor immunity. Pancreatic tumors often become highly infiltrated with immunosuppressive tumor macrophages. Our aim was therefore to test the hypothesis that αCD40 inhibits pancreatic tumor growth and spread by re-educating tumor macrophages to have anti-tumor functions, promoting a Th1 anti-tumor immune response, and gaining direct tumoricidal activity. We found that CD40 activation licenses human macrophage anti-tumor functions in vitro, and that this was dependent on the presence of T cell derived cytokines. In a syngeneic orthotopic model of pancreatic cancer (Pan02), we found that αCD40 significantly improved survival. This correlated with a significant enhancement in macrophage activation and in systemic immune activation (reduction in myeloid derived suppressor cells and increase in CD8 T cells) as determined by flow cytometry analysis. These data add support to the hypothesis that αCD40 inhibits pancreatic tumor growth through promoting anti-tumor functions of tumor macrophages. Citation Format: Nadia Luheshi, James Harper, Jane Coates-Ulrichsen, Richard Sainson, Robert W. Wilkinson, Gareth Davies, James William Legg. CD40 agonists drive the anti-tumor functions of macrophages and induce systemic immune activation survival the Pan02 orthotopic pancreatic model. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1663. doi:10.1158/1538-7445.AM2014-1663