tbuckley/cabot-search huggingface dataset:
Abstract 150: Regulation of TGFB receptor by miR21 in Sezary syndrome
Authors: Maria Grazia Narducci, Diego Arcelli, Cristina Lazzeri, Elena Pagani, Maria Cristina Picchio, Cristina Cristofoletti, Valeria Tocco, Manuela Ferracin, Francesca Sampogna, Marina Frontani, Giuseppe Alfonso Lombardo, Enrico Scala, Massimo Negrini, Elisabetta Caprini, Giandomenico Russo
Journal: Cancer Research (2011)

Abstract Sezary syndrome (SS) represents a very aggressive form of Cutaneous T Cell Lymphomas with a median overall survival of 5.1 years (range, 0.4-18.6 years). As it appears evident there are in this disease either short survivors than long survivors. Previous studies of prognostic indicators in SS showed that circulating Sézary cell count, high CD4/CD8 ratio, advanced age, high lactate dehydrogenase serum level and a high white blood cell count were associated with an unfavorable outcome. Up to now, few data have been provided concerning possible associations between immunological and genetic markers, who might provide also clues on tumor progression in this disease. In the last 10 years we have observed more than 50 Sezary Syndromes in our Institute and phenotyped them with new immunologic markers. We have also performed genetic analysis with Single Nucleotide polymorphysms (SNPs) for evaluation of genomic imbalances, mRNA expression and lately microRNA(miRNA) expression profiling. In this study we have analyzed the expression profile of 470 miRNAs using Agilent platform array in 22 SS patients. We investigated the relationship between the expression level of miRNAs and the clinical outcome of SS patients by Kaplan-Meier method and risk assessment by multivariate analysis. We also functionally investigated the role of miR-21, mapping in one of the region more frequently amplified in SS and some of its targets. We identified 45 miRNAs differentially expressed between SS and healthy controls. Using predictive analysis, a list of 19 miRNAs, including miR-21 and miR-18a, miR-342, miR-31 and let-7 members were also found. Moreover, we defined a signature of 14 miRNAs able to discriminate patients with unfavorable and favorable outcome. We show that miR-21 knockdown increases apoptosis and modulates TGF beta receptor 2 expression in vitro. The antipoptotic effect appears to be regulated through PTEN. Conversely, we were not able to observe a direct miR-21 regulation on PDCD4 gene mapping to chromosome 10q24, a frequently imbalanced region in SS. In conclusion we have identified a new prognostic miRNAs signature in SS and characterized the role of miR-21, one of the most involved in cancer, recognized as a disease and prognostic classifier in this disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 150. doi:10.1158/1538-7445.AM2011-150
Intracranial Aneurysm and Recessive Polycystic Kidney Disease
Authors: Viviane Chalhoub, Lise Abi-Rafeh, Kamal Hachem, Eliane Ayoub, Patricia Yazbeck
Journal: JAMA Neurology (2013)

Objective:To highlight the possible association of intracranial aneurysm with autosomal recessive polycystic kidney disease.Design, Setting, and Patient: To our knowledge, this association has been reported only twice in the medical literature.We herein report the case of a 21-year-old man with autosomal recessive polycystic kidney disease, presenting with subarachnoid hemorrhage secondary to a ruptured intracranial aneurysm, at our institution. Results:In the presence of only 3 cases in the medical literature, one might conclude they are a simple coincidence.However, should this association exist, such as with the dominant form, then the neurologic prognosis and even the life of young patients may be at stake. Conclusions:Given the devastating consequences of intracranial bleeding in young patients, early neurologic screening may be warranted.
466 HCV core Ag as a predictor of non-response in genotype 1 chronic hepatitis C patients treated with peginterferon alfa-2B plus ribavirin
Authors: M. Buti, A. Valdes, C. Mendez, M. Schaper, S. Sauleda, F. Rodriguez-Frias, R. Jardi, R. Esteban, J. Guardia
Journal: Journal of Hepatology (2004)
Diagnosis of Splenomegaly
Authors: Mark Walsh
Journal: JAMA (1982)

<h3>To the Editor.—</h3> In their article "Splenomegaly: An Algorithmic Approach to Diagnosis" (1981;246:2858), Edward R. Eichner, MD, and C. L. Whitfield, MD, recommend bone marrow aspiration, biopsy, and culture for patients with asymptomatic splenomegaly and normal peripheral blood smears and counts. Following normal bone marrow examination they suggest a splenic computed tomographic (CT) scan, arteriography, and finally "consideration" of diagnostic splenectomy and laparotomy. However, they note that 3% of healthy college freshmen have been reported to have asymptomatic splenomegaly<sup>1</sup>and, therefore, it is a rather common finding. A ten-year follow-up study of those same students<sup>2</sup>failed to reveal any major disease when compared with a similar control group. Conspicuously absent from the group were the lymphoproliferative diseases. In light of this study it would seem excessively invasive and costly to submit 3% of the freshmen college population to bone marrow aspirations, splenic CT scans, arteriograms, and "considerations" of
Italian authorities deny that climate change has brought malaria back to its shores
Authors: Fabio Turone
Journal: BMJ (2007)

Italian health authorities have denied claims that malaria is once again endemic in their country, calling the recent press reports that have suggested a return “baseless and irrational.” 

A report on global warming published by the Italian environmental organisation Legambiente has sparked fears of a re-emergence of malaria in Italy, receiving coverage in newspapers ( Guardian , http://environment.guardian.co.uk/climatechange/story/0,,1983892,00.html; Times , www.timesonline.co.uk/article/0,,2087-2534982,00.html) and on the internet. 

Giancarlo Majori, head of the unit on vectorborne diseases and international health at the Higher Institute of Health (Istituto Superiore di Sanita) in …
The effects of long term administration of prazosin on the microcirculation in skeletal muscles
Authors: J. M DAWSON, O. HUDLICKA
Journal: Cardiovascular Research (1989)

The effect on the microcirculaton of long term administration of the α1 blocker prazosin, which increases peripheral blood flow, was studied in skeletal muscles with differing metabolic profiles. Prazosin (50 mg·litre−1), given ad libitum for 5 weeks in the drinking water, resulted in an increase in capillarity in both fast glycolytic tibialis anterior cortex and slow oxidative soleus muscles of the rat. In tibialis anterior, the velocity of red blood cells through capillaries was increased, a smaller proportion of capillaries had intermittent flow, less time was spent stationary by red blood cells, and hence the calculated volume flow per capillary was increased. In soleus, capillary diameters were larger, but velocity, intermittency and calculated volume flow were unchanged. Therefore, suggested mechanisms for capillary growth induced by prazosin are different for the two muscles studied: increased shear stress and blood/endothelial cell interaction in the case of tibialis anterior, and increased capillary wall tension in the soleus.
Protein kinase G reverses all isoproterenol induced changes of cardiac single L-type calcium channel gating
Authors: G Klein
Journal: Cardiovascular Research (2000)

cGMP reduces the effect of beta-adrenoceptor agonists on cardiac L-type calcium current by protein kinase G activation. Stimulation of beta-adrenoceptors increases protein kinase A dependent phosphorylation of L-type calcium channels via cAMP. At the single channel level, protein kinase A dependent phosphorylation increases both availability and open probability. The present study investigates how cGMP antagonises protein kinase A induced changes of single L-type calcium channel gating.Single L-type calcium channels were recorded in the cell attached configuration of the patch clamp technique in isolated mouse ventricular myocytes.The beta-adrenoceptor agonist isoproterenol (10(-6) M) enhanced single channel peak average current by increasing availability and open probability and decreasing the time constant of long close times. 8-Br-cGMP (10(-3) M) completely reversed these effects. The phosphatase inhibitor okadaic acid (10(-6) M) did not influence the effect of 8-Br-cGMP. The protein kinase G inhibitor Rp-8Br-PET-cGMPS (10(-7) M) abated the effect of 8-Br-cGMP. Activation of protein kinase A by the hydrolysis-resistant cAMP derivative 8-Br-cAMP (10(-3) M) enhanced L-type calcium channel activity like isoproterenol and its effect was also reversed by 8-Br-cGMP.8-Br cGMP diminishes beta-adrenoceptor activation of L-type calcium channels via protein kinase G. It interacts with the beta-adrenoceptor signaling pathway distal of adenylyl cyclase. Our observations suggest that protein kinase G interacts either with protein kinase A or directly with the L-type calcium channel.
Atopy in Norwegian and Russian adults: a population‐based study from the common border area
Authors: T. Smith‐Sivertsen, V. Tchachtchine, E. Lund
Journal: Allergy (2003)

Background: Several studies have concluded that atopy is more common in Western than in Eastern Europe. We aimed to study whether a similar difference exists between Norwegian and Russian adults living in geographically adjacent areas. Methods: A cross‐sectional population‐based study was performed in Sør‐ Varanger municipality (Norway) and in the cities of Nikel and Zapolyarny (Russia). The Russian cities are heavily polluted by sulfur dioxide from local nickel industry. In addition to questionnaire information, results on IgE sensitization (S‐Phadiatop, Pharmacia &amp; Upjohn, Uppsala, Sweden) were obtained from 3134 Norwegian and 709 Russian participants. Results: A positive Phadiatop was found in 20.7% of the Norwegians (men 21.9%, women 19.7%) and in 27.5% of the Russians (men 35.7%, women 23.0%); the sex‐ and age‐adjusted relative risk of testing positive in Russia being 1.49 (95% CI 1.23–1.81). The Norwegian participants reported more atopic dermatitis and hay fever, although this difference was statistically significant only for atopic dermatitis in women. Conclusion: IgE sensitization was more common in Russia than in Norway, unlike findings from other east–west European studies. The Russians did not, however, report more atopic diseases. This discrepancy might reflect different awareness of allergies in the two countries and demonstrates the need for objective markers of atopy when comparing prevalence in different populations.
Mite Infestations of Man Contracted from Dogs and Cats
Authors: L. R. Thomsett
Journal: BMJ (1968)

Acarine infestations of the dog and cat are transmissible to man. The relation between age incidence in the host, duration of disease, and circumstances under which the animal is kept are stated. Fifty out of 65 human contacts at risk to 42 infected dogs and cats showed lesions of mite infestation; 48% of these lesions were confined to the arms and torso.It is important to consider animal mite infestation in the differential diagnosis of human pruritic and papular skin disease.
The role of overexpression and gene amplification of cyclin D1 in intrahepatic cholangiocarcinoma
Authors: Keishi Sugimachi, Shin-ichi Aishima, Ken-ichi Taguchi, Shinji Tanaka, Mitsuo Shimada, Kiyoshi Kajiyama, Keizo Sugimachi, Masazumi Tsuneyoshi
Journal: Journal of Hepatology (2001)
Anorectal Sensorimotor Dysfunction in Fecal Incontinence and Diabetes Mellitus
Authors: Arnold Wald, A. Kishore Tunuguntla
Journal: New England Journal of Medicine (1984)

We studied anorectal sensory and motor function in 14 diabetics with fecal incontinence and compared the results with those in 13 continent diabetics, 31 nondiabetics with fecal incontinence, and 11 continent nondiabetics. The threshold volume at which diabetic patients with fecal incontinence experienced rectal sensation was higher (25.0 +/- 3.4 ml [mean +/- S.E.M.]) than that in continent diabetics (13.0 +/- 2.4 ml) or nondiabetics with or without incontinence (14.5 +/- 1.5 and 12.5 +/- 1.8 ml, respectively; P less than 0.02). Biofeedback conditioning in 11 incontinent diabetics led to normal sensory thresholds in six of seven patients with pretreatment thresholds above 20 ml; five of these six became continent. Biofeedback also improved external-sphincter function in nine diabetics, eight of whom became continent. Overall, 8 of 11 diabetics had a reduction in fecal soiling after biofeedback therapy. We conclude that fecal incontinence in diabetics may be caused by decreased rectal sensation or impaired function of the external sphincter or both, and that these abnormalities can often be improved by biofeedback therapy with resultant reestablishment of bowel control.
Nuclear Angiocardiogram to Demonstrate Right Atrial Myxoma
Authors: THOMAS P. DRESSER, B RAMA RAO, JAMES W. WINEBRIGHT
Journal: Clinical Nuclear Medicine (1979)

DRESSER, THOMAS P. Ph.D., M.D., LCDR., M.C., U.S.N.R.; RAO, B RAMA M.D., CDR., M.C., U.S.N.; WINEBRIGHT, JAMES W. M.D., CDR., M.C., U.S.N. Author Information
NHSnet---learning from academia
Authors: T J Roscoe, M Wells
Journal: BMJ (1999)

The government white paper The New NHS has suggested that all general practices will be connected to NHSnet, the NHS computer network, by the year 2002. 1 NHSnet is a secure private network based on internet technologies.It will be the largest public sector project to connect computers in this country since the early 1980s, when the Joint Academic Network (JANET) was created by the universities and research councils.The policy decisions relating to security, networking products, and funding that were taken when JANET was created are pertinent to NHSnet and require deeper consideration and wider discussion.
Long-Term Nasogastric Feeding Tube
Authors: Lee R. Sataline
Journal: JAMA (1969)

<h3>To the Editor:—</h3> The only major problem of which I am aware has occurred when the ligatures holding the mercury have disrupted. The unweighted tube may then ascend into the larynx where it can produce airway obstruction somewhat akin to that reported with the esophageal balloon portion of the Sengstaken-Blakemore tube (<i>New Eng J Med</i><b>259</b>:701, 1958). I was taught the use of the Penrose tube for nasogastric feeding when an intern (1956) so it apparently is not a new idea. However, it is useful, and I continue to recommend it.
Immunosuppressive factor(s) specific for L-glutamic acid(50)-L- tyrosine(50) (GT). II. Presence of I-J determinants on the GT-suppressive factor
Authors: J Theze, C Waltenbaugh, ME Dorf, B Benacerraf
Journal: The Journal of Experimental Medicine (1977)

The responses to the synthetic antigens, L-glutamic acid(60)-L- alanine(30)-L-tyrosine(10) (GAT) and L-glutamic acid(50)-L-tyrosine(50) (GT) are controlled by genes in the I region of the mouse H-2 complex (1-3). Preimmunization of the mice bearing the H-2(p,q,s) nonresponder haplotypes with GAT stimulates the development of suppressor T cells that inhibit in vivo or in vitro antibody responses to GAT complexed to the immunogenic carrier, methylated bovine serum albumin (GAT-MBSA) (4). The copolymer GT is not immunogenic in any inbred mouse strain tested, and has a suppressive effect on the antibody responses to GT-MBSA in mouse strains bearing the H-2(d,f,k,s) haplotypes; suppressor T cells have been demonstrated to be responsible for specific GT suppression (3). We have obtained specific suppressive extracts from thymus and spleen cells of GAT-or GT-primed suppressor strains (5,6). The specific suppressive T-cell factors in the active extracts have been characterized (6,7) and appear similar to the carrier-specific suppressor factor described by Tada and Taniguchi (8). These products belong to a family of newly identified molecules coded for by the I region of the H-2 complex with affinity for antigen and helper (9,10) or suppressive (5-8) regulatory activity on the immune response. Recently, Tada et al. have reported that the keyhole limpet hemocyanin (KLH)-specific suppressor factor is coded for by the I-J subregion of the H-2 complex (11). We now demonstrate also that a GT-specific suppressor factor extracted from the spleens and thymuses of B10.BR (H-2(k)) mice bears determinants controlled by the I-J subregion of the H-2 complex.
CDC Investigators Explore New Territory in Aftermath of Unrest in Los Angeles
Authors: Paul Cotton
Journal: JAMA (1992)

GOING WHERE apparently no epidemiologists have ever gone before, a team from the Centers for Disease Control (CDC) in Atlanta, Ga, has taken the public health approach to the most extreme outbreak in the ongoing epidemic of urban violence. Seven investigators descended on Los Angeles, Calif, as the riots there ebbed. "Our mission," says Mark Rosenberg, MD, "was first to assess the injuries that occurred as a result of the disturbance and second to work with the community to help them develop ways of starting and supporting long-term approaches to youth violence prevention." Violence, says Rosenberg, who is director of the Injury Control Division at the CDC, should be susceptible to the same public health approach used to eradicate smallpox and reduce the incidence of heart disease—epidemiologic research to better define risk factors, followed by the development, implementation, and evaluation of interventions. <h3>Need to Act Quickly</h3> As with acquired immunodeficiency
Changing the Culture of Academic Medicine: Perspectives of Women Faculty
Authors: Helen Anne D’Alessandro
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical societies react against public access to findings
Authors: Jeanne Lenzer
Journal: BMJ (2005)

An initiative of the US National Institutes of Health (NIH) to make the results of publicly funded research freely accessible to the public has triggered a backlash.

The policy, announced two weeks ago by the director of the NIH, Elias Zerhouni, encourages researchers funded by the NIH to submit their manuscripts to the free access, full text archive of PubMed Central within 12 months of their manuscripts being accepted for publication (bmj.com, 30 Apr 2005, News Extra).

The American Society of Hematology and the American Association for Cancer Research sent statements to members emphasising, “The NIH policy is a request; it is NOT a requirement.” In an editorial in Blood James George, president of the American …
Dr Uton Muchtar Rafei was born in Bandung, Indonesia, and has been the regional director of the WHO's South East Asia region since 1994
Authors: F. Godlee
Journal: BMJ (1998)

There are of course the ongoing challenges of tackling the disease burden, and ensuring health care for all. In addition, it is imperative that, on the one hand, health is placed at the centre of development by all nations, and, on the other, we are able to reduce disparities in people's access to health. This is specially so for the poor, women, and other vulnerable groups. Conditions have to be created that promote health and also increase the capacity of people to deal with their own problems. All this must be attained while upholding and enforcing health ethics, particularly in relation to technology development to enable it to serve better the needs of both the poor and the developed countries.

These challenges can be addressed only if health is backed by political will and if there is a national and global consensus for action. Now is also the time to project women as leaders, particularly in health promotion and development, so that they are empowered to take decisions on key issues such as reproductive health and nutrition.

The WHO ignores the impact on health of socioeconomic …
Airway Smooth Muscle as a Target for Asthma Therapy
Authors: Julian Solway, Charles G. Irvin
Journal: New England Journal of Medicine (2007)

The precise role of airway smooth muscle in the pathogenesis of asthma remains uncertain. The contraction of airway smooth muscle certainly causes acute narrowing of the airway and airflow obstruction in asthma, and smooth-muscle mass is increased in asthmatic airways. However, whether airway smooth muscle generates sufficient force in vivo to account for the excessive airway obstruction that characterizes asthma is unknown. Abnormalities in the dynamics of contraction,1 in the capacity of smooth muscle to maintain shortening in the face of load fluctuations imposed by tidal breathing,2 or in the capacity to relax3 represent other important mechanisms by which airway . . .
Hartnup Disorder in a New England Family
Authors: Joanne Pomeroy, Mary L. Efron, Jacqueline Dayman, Dick Hoefnagel
Journal: New England Journal of Medicine (1968)

IN 1956 Baron et al.1 described an autosomal recessive syndrome characterized by episodes of cerebellar ataxia, intermittent photosensitive pellagra-like rash and mental retardation; it was accompanied by a renal aminoaciduria of tryptophan and other neutral amino acids and an excess of urinary indoles. Further reports have shown that the clinical features lack uniformity and the biochemical abnormality can be associated with normal physical and mental health.2 The basic error is a defect of amino acid transport into the cells of the small intestine and the proximal renal tubules. It has been surprising that to date no cases have been reported . . .