ELECTROCARDIOGRAPHIC CHANGES PRODUCED BY LOCALIZED HYPOTHALAMIC STIMULATIONS
Authors: S J WEINBERG, J M FUSTER
Journal: Annals of Internal Medicine (1960)

Article1 August 1960ELECTROCARDIOGRAPHIC CHANGES PRODUCED BY LOCALIZED HYPOTHALAMIC STIMULATIONSS. J. WEINBERG, M.D., F.A.C.P., JOAQUIN M. FUSTER, M.D.S. J. WEINBERG, M.D., F.A.C.P., JOAQUIN M. FUSTER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-2-332 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe background of our present knowledge of neurocardiac relationships has previously been summarized.1, 2, 3 The exact location of the diencephalic structures capable of influencing the electrocardiogram has heretofore not been determined. The investigation presented here was aimed at clarifying the possible role of the hypothalamus in the genesis of some electrocardiographic configurations of clinical interest.METHODSIn the present study the hypothalamus of the cat was explored throughout by means of the Horsley-Clarke apparatus. Three hundred seventy-five individual diencephalic points were electrically stimulated in 10 animals. The location of each point stimulated by the tip of the electrode was...Bibliography1. Weinberg SJ: Hypothalamic dysfunction. A review of experimental, and clinical observations of cardiac and renal aspects, California Med. 77: 253-268, 1952. MedlineGoogle Scholar2. Schütz E: Physiologie des Herzens, Chapter 16, 1958, Springer, Berlin. CrossrefGoogle Scholar3. WeinbergHaley SJTJ: Centrally mediated effects of cardiac drugs: strophanthin-K, quinidine, and procaine amide, Circul. Res. 3: 103-108 (Jan.) 1955. CrossrefMedlineGoogle Scholar4. Ranson SW, quoted in Boon, A. A.: Comparative anatomy and physio-pathology of the autonomic hypothalamic centres, Acta psychiat. et neurol. Suppl. 18: 53-129, 1938. Google Scholar5. Mitchell GA: Anatomy of the autonomic nervous system, 1953, E. and S. Livingstone, Ltd., Edinburgh and London, p. 111. Google Scholar6. 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Van Bogaert A: Hypothalamus et reactions cardio-vasculaires d'origine centrale, Arch. internat. de pharmacodyn. et de thérap. 52: 137-176, 1936. Google Scholar18. FusterWeinberg JMSJ: Bioelectrical changes of the heart cycle induced by stimulation of diencephalic regions, Exper. Neurol. 2: 26-39, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 4, 1960.Presented at the Forty-first Annual Session of The American College of Physicians, San Francisco, California, April 5, 1960.From the Departments of Medicine, Psychiatry and Anatomy, University of California at Los Angeles.†The work on which this paper is based was supported in part by private subscription of Mrs. Mary E. Osenbach.Requests for reprints should be addressed to S. J. Weinberg, M.D., 1015 Gayley Avenue, Los Angeles 24, California. 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