IMMUNOLOGIC MECHANISMS IN IDIOPATHIC AND NEONATAL THROMBOCYTOPENIC PURPURA
Authors: W J HARRINGTON, C C SPRAGUE, V MINNICH, C V MOORE, R C AULVIN, R DUBACH
Journal: Annals of Internal Medicine (1953)

Article1 March 1953IMMUNOLOGIC MECHANISMS IN IDIOPATHIC AND NEONATAL THROMBOCYTOPENIC PURPURAWILLIAM J. HARRINGTON, M.D., CHARLES C. SPRAGUE, M.D., VIRGINIA MINNICH, M.S., CARL V. MOORE, M.D., F.A.C.P., ROBERT C. AULVIN, B.S., REUBENIA DUBACH, Ph.D.WILLIAM J. HARRINGTON, M.D., CHARLES C. SPRAGUE, M.D., VIRGINIA MINNICH, M.S., CARL V. MOORE, M.D., F.A.C.P., ROBERT C. AULVIN, B.S., REUBENIA DUBACH, Ph.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-3-433 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe mechanisms responsible for the low platelet count in idiopathic thrombocytopenic purpura are not well understood despite the careful studies by many competent investigators. The thrombocytopenia has been attributed to:1. A decrease in the rate of platelet formation from megakaryocytes1, 2 because of splenic inhibition of these cells;3, 4, 5, 62. An increase in the rate of platelet destruction by the spleen,7, 8, 9, 10, 11, 12 and3. A combination of damage to both megakaryocytes and circulating platelets.13, 14Evidence to support the latter concept has been presented recently. A thrombocytopenic factor which damages circulating platelets and...Bibliography1. Frank E: Die essentielle Thrombopenie. (Konstitionelle Purpura Pseudo-Hämophilie) I. Klinisches Bild., Berl. klin. Wchnschr. 52: 454, 1915. II. Pathogenese, Ibid. 52: 490, 1915. Google Scholar2. Frank E: Die hämorrhagischen Diathesen, in Schittenhelm, A.: Handbuch der Krankheiten des Blutes und der Blutbildenden Organe, 1925, Julius Springer, Berlin, vol. 2, p. 289. CrossrefGoogle Scholar3. Seeliger S: Über Organbefunde und ihre Bedeutung für die Pathogenese bei essentieller Thrombopenie und Aleukie, Klin. Wchnschr. 3: 731, 1924. CrossrefGoogle Scholar4. 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CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented (in part) at the Thirty-third Annual Session of the American College of Physicians, Cleveland, Ohio, April 23, 1952.From the Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.This work was supported by Grant No. H-22 C (6) from the National Heart Council of the U. S. Public Health Service, Bethesda, Maryland.†On assignment from the National Institute of Arthritis and Metabolic Diseases, U. S. Public Health Service. 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A comparative study using flow cytometry, a whole platelet ELISA, and an antigen capture ELISAAutoimmune ThrombocytopeniasMANAGEMENT OF FETAL AND NEONATAL ALLOIMMUNE THROMBOCYTOPENIAMortality in immune thrombocytopenic purpura: Report of seven cases and consideration of prognostic indicatorsNeonatal thrombocytopenia and hidden maternal autoimmunityÜbersichtFetal and neonatal alloimmune thrombocytopenia: current trends in diagnosis and therapySurgical treatment of immune thrombocytopenic purpuraFetal and Neonatal ThrombocytopeniaHPA-5b (Br a ) neonatal alloimmune thrombocytopenia: clinical and immunological analysis of 39 casesBr b , a Platelet Alloantigen Involved in Neonatal Alloimmune ThrombocytopeniaAntigen-Specific Assays in Immune ThrombocytopeniaPlatelet aggregating IgG antibody to platelet surface glycoproteins associated with thrombosis and thrombocytopeniaClinical Uses of Intravenous ImmunoglobulinsSamuel A. Berkman, MD, Martin L. Lee, PhD, Robert Peter Gale, MD, PhDLong-Term Danazol Therapy in Autoimmune Thrombocytopenia: Unmaintained Remission and Age-Dependent Response in WomenYeon S. Ahn, MD, Rafael Rocha, MD, Ravindra Mylvaganam, PhD, Rolando Garcia, MD, Robert Duncan, PhD, William J. Harrington, MDNeonatal alloimmune thrombocytopeniaAutoantibodies in chronic ITPRelative importance of total versus external platelet-associated IgGThe comparison of gammaglobulin to steroids in treating adult immune thrombocytopeniaPlatelet survival and turnover: Important factors in predicting response to splenectomy in immune thrombocytopenic purpura348 CASES OF SUSPECTED NEONATAL ALLOIMMUNE THROMBOCYTOPENIASPLENECTOMY FOR IMMUNE THROMBOCYTOPENIC PURPURA: AUCKLAND EXPERIENCE 1979–87Maternal alloimmunization to HLA, platelet and granulocyte-specific antigens during pregnancy: its influence on cord blood granulocyte and platelet countsManagement of Alloimmune Neonatal and Antenatal ThrombocytopeniaAlloantigene von ThrombozytenIntravenous Immunoglobulin Therapy of Idiopathic Thrombocytopenic Purpura in Childhood and AdolescenceA new intravenous immunoglobulin in adult and childhood idiopathic thrombocytopenic purpura: a reviewImmunotherapy of Idiopathic Thrombocytopenic Purpura and Autoimmune NeutropeniaAre Platelet-Antibody Tests Worthwhile?Colloid and Surface Phenomena in Immunology[31] Use of platelets as drug carriers for the treatment of hematologic diseasesClinical significance of surface and internal pools of platelet-associated immunoglobulins in immune thrombocytopeniaImmunology of the Platelet SurfaceIdiopathic Thrombocytopenic PurpuraTreatment of refractory chronic idiopathic thrombocytopenic purpura with high dose intravenous immunoglobulinPLATELET AUTOANTIGENS IN CHRONIC ITPImmunosuppressant therapy of idiopathic thrombocytopenic purpuraINTERACTION OF PHAGOCYTES WITH OTHER BLOOD CELLS AND WITH PATHOGENIC AND NONPATHOGENIC MICROBESTreatment of Idiopathic Thrombocytopenic PurpuraNeonatal neutropenia due to maternal autoantibodies against neutrophils.Danazol for the Treatment of Idiopathic Thrombocytopenic PurpuraStudies by Enzyme-Linked Immunosorbent Assay (ELISA) of Antiplatelet Antibody and Transient Neonatal Thrombocytopenic Purpura*HLA antigens and maternal antibodies in allo-immune neonatal thrombocytopeniaPlatelet serology and transfusionThe prenatal prediction of thrombocytopenia in infants of mothers with clinically diagnosed immune thrombocytopeniaChronic Idiopathic Thrombocytopenic PurpuraUltrastructural Diagnosis of Histologically Atypical Idiopathic Thrombocytopenic PurpuraEffect of Heterologous Antibody on Human Platelet Prostaglandin SynthesisIdiopathic thrombocytopenic purpura occurring in Hodgkin disease after splenectomy: Report of two cases and review of the literatureAcute idiopathic thrombocytopenic purpura in childrenThe Treatment of Idiopathic Thrombocytopenia with Vinblastine-Loaded PlateletsHämatologie des NeugeborenenTurnover of Blood CellsThe Pathogenesis of Immune Thrombocytopenic PurpuraDifferent Antiplatelet Antibody Specificities in Immune Thrombocytopenic PurpuraMyasthenia gravis: übertragbarer "myasthenogener" Faktor im Serum von PatientenIn vitro production of platelet-binding IgG in childhood idiopathic thrombocytopenic purpuraIdiopathic thrombocytopenic purpura in childrenQuantitation of Platelet-Binding IgG Produced in Vitro by Spleens from Patients with Idiopathic Thrombocytopenic PurpuraPREGNANCY COMPLICATED BY ACUTE IDIOPATHIC THROMBOCYTOPENIC PURPURA. A REPORT OF TWO PATIENTS TREATED BY SIMULTANEOUS CAESAREAN SECTION AND SPLENECTOMYLate results of splenectomy in hematologic disordersSerological techniques for the detection of antibodies to porcine thrombocytes. 1. The agglutination, fluorescent antibody and immunodiffusion techniquesStimulation of Nonimmunized Lymphocytes by Platelet-Antibody Complexes in Idiopathic Thrombocytopenic PurpuraHyperaggregation effect in idiopathic thrombocytopenia and multiple transfused patientsImmunoglobulin Synthesis in Vitro by Splenic Tissue in Idiopathic Thrombocytopenic PurpuraIdiopathic Thrombocytopenic Purpura and the ITP SyndromeCELLULAR IMMUNITY TO AUTOLOGOUS PLATELETS AND SERUM-BLOCKING FACTORS IN IDIOPATHIC THROMBOCYTOPENIC PURPURAScleroderma associated with thrombocytopenia and Coombs-positive hemolytic anemiaIdiopathic thrombocytopenic purpura with normal platelet survival timeCLINICAL DISORDERS RELATED TO BLOOD PLATELETSTRANSFUSION AND PRESERVATIONIncidences transfusionnelles des antigènes leucocytaires et plaquettairesL'allo-immunisation fœto-maternelle contre les antigènes leucocytaires et plaquettairesTurnover in Cells and TissuesHereditary Thrombocytopenia with an Intrinsic Platelet DefectUse of Compatible Platelet Transfusions in Treatment of Congenital Isoimmune Thrombocytopenic PurpuraLITERATURVERZEICHNISAntigenicity of Blood PlateletsBIBLIOGRAPHYSites of Platelet Destruction in Idiopathic Thrombocytopenic PurpuraNEONATAL THROMBOCYTOPENIA: ASSESSMENT OF AETIOLOGY AND PROGNOSISPLATELET COUNTS AND PLASMA FIBRINOGEN LEVELS IN ERYTHROBLASTOSIS FOETALISIso-Immune Neonatal Purpura Caused by Anti-PlGrLyB1Hemopoietic SystemIrregular Blood CoagulationDie Thrombozytengruppen und ihre klinische BedeutungIdiopathic Thrombocytopenic PurpuraIdiopathic thrombocytopenic purpura in childhoodTHE EFFECT OF INCUBATION OF NORMAL PLATELETS WITH PLASMA FROM PATIENTS WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA ON THE PLATELET'S LIFE SPANDie hämorrhagischen DiathesenDie Entwicklung der Blutgruppenmerkmale und Hämagglutinine mit ontogenetischen und phylogenetischen BetrachtungenSpecific isoantibodies in cystic fibrosisPassage of Leukemic Cells across the PlacentaChronic Idiopathic GranulocytopeniaAutoimmunization and other types of indirect damage to host cells as factors in certain protozoan diseasesSTUDIES OF THE LIFE SPAN AND FATE OF PLATELETSRecurrent Acute Idiopathic Thrombocytopenic PurpuraThrombocytopenic Bleedings in Young Pigs due to Maternal IsoimmunizationIndikationen zur Splenektomie bei BlutkrankheitenMorbus haemolyticus neonatorum infolge AB0-Inkompatibilität und seltene foetogene SensibilisierungenEffect of Anti-Platelet Antibodies on the in Vitro Uptake of 5-Hydroxytryptamine by Blood PlateletsHemangioma associated with thrombocytopeniaIdiopathic Thrombocytopenic Purpura in ChildhoodMATERNAL AND NEONATAL PLATELET ANTIBODIES IN A CASE OF CONGENITAL THROMBOCYTOPENIAStudies on Platelet Antibodies in ManExperimental thyroiditis and the placental transfer of auto-antibodiesReclassification of the Thrombocytopenias by the Cr 51 -Labeling Method for Measuring Platelet Life SpanThe clinical manifestations of systemic lupus erythematosusVitamin K for the Newborn?Watching the Newborn for DiseaseCongenital Thrombocytopenic Purpura Treated by Exchange TransfusionDiaplacentare �bertragung von Autoantik�rpernThe effects of anti-leucocyte-platelet serum on young miceImmunothrombopenie�ber die thrombocyt�ren AutosensibilisierungenLIMITS TO FUNCTIONAL HYPERTROPHY IN HIGH-OUTPUT FAILURE*JOHN H. FRENSTER, M.D.Coating of "O" Platelets with A and B Group SubstancesResearch in the field of allergyNEONATAL PURPURA WITH PLATELET ISO-ANTIBODY IN MATERNAL SERUMImmune Platelet Iso-AntibodiesThrombocytopenia in Pregnancy following Splenectomy**Presented at the Twenty-first Annual Meeting of the South Atlantic Association of Obstetricians and Gynecologists, Roanoke, Va., Feb. 4-7, 1959.The Mixed Antiglobulin Reaction in the Detection of Human Iso-Antibodies against Leucocytes, Platelets and HeLa CellsCongenital and neonatal thrombocytopenic purpuraSerological and Genetical Studies on a Platelet Antigen (Zw)HEMOLYTIC DISORDERS: SOME HIGHLIGHTS OF TWENTY YEARS OF PROGRESS*†LAWRENCE E. YOUNG, M.D., F.A.C.P.Simultaneous placental transfer of factors responsible for L.E. cell formation and thrombocytopeniaNewer Laboratory Procedures: Their Application to the Investigation of Pædiatric DisordersCasesChronic idiopathic immunoneutropeniaPost-transfusion thrombocytopenic purpuraTherapy of the purpurasThe Management of Acute Episodes in Patients with Bleeding DiseasesPlatelet Antibodies in Hodgkin's DiseaseSome Studies on Leukocyte AgglutininsIdentification and Significance of Platelet AntibodiesA survey of Allergy's present positionVorkommen leukocytenagglutinierender und thrombocytärer Antikörper bei einem Fall von akutem Lupus erythematosus disseminatusA Serum Anti-Platelet-Thromboplastic Factor in Thrombocytopenia and the Effects of CortisoneEditorialBlutungs�bel bei NeugeborenenThrombocytopenic Purpura and ChickenpoxPathogenetic Mechanisms in Thrombocytopenic StatesImmunohämatologie der Thrombocyten und LeukocytenPlatelet groups and typesPhysiologische Beziehungen zwischen Milz und KnochenmarkDie Immunthrombocytopenien. Ein neues Gebiet der Immunh�matologieCoagulation, Hemorrhage and ThrombosisHorror ComicsIdiopathic Thrombocytopenic PurpuraAUTOANTIBODIES AND THE HYPER-REACTIVE STATE IN THE PATHOGENESIS OF DISEASEDie Differentialdiagnose der GerinnungsstörungenThe hematologic role of the lung in manCORTICOTROPHIN AND CORTISONE IN IDIOPATHIC THROMBOCYTOPENIC PURPURAHemocytopenic Reactions to Modern DrugsPlatelet Antibody Tests in the Diagnosis of Purpura 1 March 1953Volume 38, Issue 3Page: 433-469KeywordsArthritisHeartIdiopathic thrombocytopenic purpuraMedical servicesMegakaryocytesMetabolic disordersPlatelets ePublished: 1 December 2008 Issue Published: 1 March 1953 Copyright & PermissionsCopyright, 1953, by The American College of PhysiciansPDF downloadLoading ...