tbuckley/cabot-search huggingface dataset:
Phase I trial of recombinant immunotoxin CAT-8015 (HA22) in multiply relapsed hairy cell leukemia.
Authors: R. J. Kreitman, M. S. Tallman, S. E. Coutre, T. Robak, W. H. Wilson, M. Stetler-Stevenson, P. Noel, D. J. FitzGerald, J. T. McDevitt, I. Pastan
Journal: Journal of Clinical Oncology (2010)

6523 Background: CAT-8015 (HA22) contains the Fv domains of the anti-CD22 Mab RFB4 and truncated pseudomonas exotoxin, inducing cell death after binding, internalization, and ADP-ribosylation of elongation factor 2. CAT-8015 is a high-affinity mutant of BL22 (CAT-3888), with increased cytotoxicity toward chronic lymphocytic leukemia (CLL) and hairy cell leukemia (HCL) cells ex vivo. Methods: To determine the clinical activity of CAT-8015, separate phase I trials were initiated in CLL, HCL, and non-Hodgkin lymphoma, and the HCL trial completed accrual. Eligible patients had several prior therapies including purine analogs and needed treatment for cytopenias or symptoms. CAT-8015 was administered over 30 min iv days 1, 3 and 5 (QODx3) at 28-day intervals for up to 10 cycles. Results: 28 HCL patients received CAT-8015: 3 each at 5, 10, 20, and 30 ug/kg QODx3, 4 at 40 and 12 at 50 ug/kg QODx3. Patients had 2-7 (median 3) prior therapies. Patients received 1-9 (median 4) cycles of CAT-8015 each. Dose-limiting toxicity (DLT) was not observed. Two patients, with cycle 3 of 30 and cycle 5 of 50 ug/Kg QOD x3, had a grade 2 reversible hemolytic uremic syndrome (HUS) with peak creatinine of 1.53-1.66 mg/dL and platelet nadir of 111,000-120,000/mm3. Drug-related toxicities in 25-60% of the 28 patients included (in decreasing frequency) grade 1-2 hypoalbuminemia, edema, fever, ALT and AST elevations, headaches, and nausea. Of 25 evaluable patients, 44% made antibodies neutralizing > 75% of the cytotoxicity of 1,000 ng/mL of CAT-8015. Responses were achieved at all dose levels. The overall response rate was 79% including 12 (43%) of 28 HCL patients achieving complete remission (CR). Of the 12 CRs, 11 (92%) are ongoing 7-29 (median 21) months after enrollment. Conclusions: CAT-8015 is active in relapsed/refractory HCL and is without DLT after completion of expansion at the highest dose level (50 ug/Kg x3) to 12 patients. These results justify further treatment of patients at this dose level to further explore efficacy and safety. Dose-escalation will continue in a separate trial to determine if the increased cytotoxic activity of CAT-8015 compared to CAT-3888 will be associated with significant efficacy in CLL and non-Hodgkin lymphoma. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration MedImmune
Abstract 1732: Three-dimensional Left Atrial And Oesophagus Reconstruction Using Cardiac C-arm Computed Tomography For Ablation Of Atrial Fibrillation: Preliminary Experience
Authors: Georg Noelker, Harald Marschang, Klaus Gutleben, Guido Ritscher, Martin Schmidt, Anil M Sinha, Harald Rittger, Nassir F Marrouche, Johannes Brachmann
Journal: Circulation (2007)

Objectives: Threedimensional imaging has been widely adopted as a standard component of the AF ablation procedure. We tested the feasibility of the new 3D imaging system (DYNA-CT) using the C-arm to reconstruct the left atrium and the oesophagus and compared it to the established CT-scan imaging modality. Methods and results: We included 14 consecutive patients (7 female, mean age 54 +/− 12) presenting for PVAI in the study. Prior to the ablation procedure (&lt;24 hours) a 64 slice CT-scan was used to reconstruct the left atrium and oesophagus in all study patients. Immediately before performing the transseptal puncture a rotational angiography (RTA) was performed with a delay of 4.5 to 8.5 seconds after administration 84 ml of contrast media into the pulmonary artery via a standard 6F pigtail catheter with a flow rate of 15ml/s. The pigtail catheter was flushed immediately after contrast media (CM) administration in inspiration breath hold. In 12 patients 80 ml of barium based CM was administered orally immediately before RTA to contrast the ESO. The acquired CT and RTA left atrial and oesophagus reconstructed images were compared using the Leonardo software (Fig. 1 ). Table 1 demonstrates results of comparison between CT and RTA data. Conclusions: From our initial experience DYNA-CT seems to provide a feasible and reliable left atrial and oesophagus images to help mapping and navigation during the PVAI. Table 1: Anatomical structures demonstrated using the 2 imaging modalities
Sirolimus-Eluting Stents for Treatment of Infrapopliteal Arteries Reduce Clinical Event Rate Compared to Bare-Metal Stents
Authors: Aljoscha Rastan, Klaus Brechtel, Hans Krankenberg, Rainer Zahorsky, Gunnar Tepe, Elias Noory, Uwe Schwarzwälder, Roland Macharzina, Thomas Schwarz, Karlheinz Bürgelin, Sebastian Sixt, Thilo Tübler, Franz-Josef Neumann, Thomas Zeller
Journal: Journal of the American College of Cardiology (2012)
Overview: clinical and physiological comparison of meditation with other self-control strategies
Authors: Deane H. Shapiro
Journal: American Journal of Psychiatry (1982)

In 1977 the American Psychiatric Association called for a critical examination of the clinical effectiveness of meditation. The author provides a review of the literature bearing on clinical and physiological comparisons of meditation with other self-control strategies. He begins by providing a definition of mediation and then cites the literature comparing mediation with such self-regulation strategies as biofeedback, hypnosis, and progressive relaxation. He pays particular attention to the "uniqueness" of mediation as a clinical intervention strategy a well as the adverse effects of meditation. Finally, he offers suggestions and guidelines for future research.
Abstract 3028: Cardiac-Specific Overexpression of microRNA-494 Protects Against Ischemia/Reperfusion-Induced Injury by Targeting PTEN, ROCK1 and CaMKII{Delta}
Authors: Xiaohong Wang, Wenfeng Cai, Xiaoping Ren, Pengyuan Zhang, Evangelia G Kranias, Guo-Chang Fan
Journal: Circulation (2009)

We recently observed that microRNA-494 (miR-494) was downregulated in murine hearts upon ischemia/reperfusion (I/R) in vivo , consistent with other findings in human infarcted hearts. However, miR-494 was significantly upregulated in ex vivo I/R murine hearts. To further elucidate the functional role of miR-494 in both ex vivo and in vivo I/R-induced cardiac injury, we generated a mouse model with cardiac-specific overexpression of miR-494. All miR-494 transgenic (TG) mice were healthy and showed no apparent cardiac morphological or pathological abnormalities. TG hearts with 4-fold overexpression of miR-494 and wild-type hearts were then subjected to global no-flow I/R (40 min/120 min) using the Langendorff preparation. TG hearts exhibited improved recovery of contractile performance over the whole reperfusion period. This improvement was accompanied by a 2.5-fold decrease in lactate dehydrogenase released from the TG hearts. The extent of apoptotic cell death was also significantly decreased by ~70%, which was measured by TUNEL staining and DNA fragmentation. Furthermore, in vivo experiments of 30 min myocardial ischemia, via coronary artery occlusion, followed by 24 h reperfusion, showed that the infarct-to-risk region ratio was 6.1±1.4% in TG hearts (n=7) compared to 21.5±3.1% in WT hearts (n=9, p<0.001). Using Target-Scan software, we identified PTEN, ROCK1 and CaMKII Δ , three well-known proteins that are detrimental in I/R, as important candidate targets for miR-494. To test this prediction, we examined the expression levels of PTEN, ROCK1 and CaMKII Δ in TG and WT hearts. Indeed, the protein levels of PTEN, ROCK1 and CaMKII Δ were decreased by 60%, 55%, and 30%, respectively, in miR-494 hearts, relative to WT hearts. Furthermore, we analyzed the effect of miR-494 on 3′UTRs’ activities of PTEN, ROCK1 and CaMKII Δ utilizing a luciferase reporter assay. In agreement with the protein level data, the 3′UTRs’ activities of PTEN, ROCK1 and CaMKII Δ were strongly inhibited (up to 4-fold) by miR-494. Taken together, our findings demonstrate that increased miR-494 levels in the heart protect against I/R-induced injury via antithetical regulation of PTEN, ROCK1 and CaMKII Δ . Thus, miR-494 may constitute a new therapeutic target for ischemic heart diseases.
Simultaneous Determination of Aortic Valve Area by the Gorlin Formula and by Transesophageal Echocardiography Under Different Transvalvular Flow Conditions
Authors: Jean-Claude Tardif, Andressa Giestas Rodrigues, Jean-François Hardy, Yves Leclerc, Robert Petitclerc, Rosaire Mongrain, Lise-Andrée Mercier
Journal: Journal of the American College of Cardiology (1997)
Abstract 12826: Importance of Flexibility in Shock Polarity With Subcutaneous Only Implantable Cardioverter-Defibrillators
Authors: Warren M Smith, Margaret Hood, Andrew Grace, Gust Bardy
Journal: Circulation (2010)

Introduction: An entirely subcutaneous ICD (S-ICD) has recently been shown to be effective in treating patients with ventricular tachyarrhythmias. This study explored the clinical utility of incorp...
Impact of Initial Shunt Type on Cardiac Size and Function in Children With Single Right Ventricle Anomalies Before the Fontan Procedure
Authors: Peter C. Frommelt, Eric Gerstenberger, James F. Cnota, Meryl S. Cohen, Jessica Gorentz, Kevin D. Hill, J. Blaine John, Jami C. Levine, Jimmy Lu, William T. Mahle, Rachel T. McCandless, Luc Mertens, Gail D. Pearson, Carolyn Spencer, Deepika Thacker, Ismee A. Williams, Pierre C. Wong, Jane W. Newburger
Journal: Journal of the American College of Cardiology (2014)
Differential Oncogenic Effects of Methylnitrosourea2
Authors: James A. Swenberg, Adalbert Koestner, Wolfgang Wechsler, Marshall N. Brunden, Hiroshi Abe
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Differential Oncogenic Effects of Methylnitrosourea Get access James A. Swenberg, James A. Swenberg Search for other works by this author on: Oxford Academic PubMed Google Scholar Adalbert Koestner, Adalbert Koestner Search for other works by this author on: Oxford Academic PubMed Google Scholar Wolfgang Wechsler, Wolfgang Wechsler Search for other works by this author on: Oxford Academic PubMed Google Scholar Marshall N. Brunden, Marshall N. Brunden Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroshi Abe Hiroshi Abe Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 54, Issue 1, January 1975, Pages 89–96, https://doi.org/10.1093/jnci/54.1.89 Published: 01 January 1975 Article history Received: 03 May 1974 Accepted: 06 September 1974 Published: 01 January 1975
Abstract 59: The Incidence Of Pulmonary Aspiration With Laryngeal Mask Airway Use During Cardiopulmonary Resuscitation And Positive Pressure Ventilation In Swine.
Authors: Brian Suffoletto, James Menegazzi, Eric Logue, David Salcido
Journal: Circulation (2007)

Objective: Pulmonary aspiration of gastric contents occurs 20 –30% of the time during cardiopulmonary resuscitation (CPR) of cardiac arrest. This is due to loss of protective airway reflexes, pressure changes generated during CPR, and positive pressure ventilation (PPV). Even though the American Heart Association (AHA) has recommended the laryngeal mask airway (LMA) as an acceptable alternative airway for use by EMS personnel, concerns over the capacity of the device to protect from pulmonary aspiration remain. We sought to determine the incidence of aspiration after LMA placement, CPR and PPV. Methods: We conducted a prospective study on 16 consecutive post-experimental mixed-breed domestic swine of either sex (mean mass 25.7 ±1.4 kgs). A standard size-4 LMA was modified so that a vacuum catheter could be advanced into and past the LMA diaphragm. The LMA was placed into the hypopharynx and its position confirmed using End-tidal CO 2 and direct visualization of lung expansion. Fifteen milliliters of heparinized blood were instilled into the pharynx. After 5 PPVs with a mechanical ventilator, chest compressions were performed for 60s with asynchronous ventilations continuing at a rate of 12 per minute. After chest compressions, a suction catheter was inserted through the cuff and suction applied for approximately 1 minute. The catheter was removed and inspected for signs of blood. The LMA cuff was deflated and the LMA removed. The intima of the LMA diaphragm was inspected for signs of blood. In a validation cohort of 4 animals, the LMA was reinserted, a cricothyrotomy performed and 5 mL of blood instilled directly into the trachea. Results: There were 0/16 (95% CI=0 –17%) with a positive tests for the presence of blood in both the vacuum catheter and the intima of the LMA diaphragm. In the validation cohort, all four were positive for blood in both the vacuum catheter and the intima of the LMA diaphragm. Conclusions: In this simple model of regurgitation of after LMA placement, there was no sign of pulmonary aspiration, and no evidence that blood had passed beyond the seal created by the LMA cuff. Concerns over aspiration with LMA use may be unfounded. Future studies should determine the frequency of pulmonary aspiration after LMA placement in the clinical setting.
Radiofrequency thermal ablation (RFA) of liver tumors: percutaneous and open surgical approaches.
Authors: A Crucitti, F M Danza, A Antinori, Antonacci Vincenzo, P G V Pirulli, E Bock, P Magistrelli
Journal: Journal of experimental & clinical cancer research (2003)

Radiofrequency Thermal Ablation (RFA) of liver tumors is done by percutaneous, laparoscopic and open surgical approach. Selection criteria for percutaneous or open surgical ablation of 65 hepatic lesions are here evaluated in 45 patients treated in a two-years period. Twenty-five patients were males and 20 females, ages ranged from 35 to 80 years (mean 63 years). RFA was performed in 57 procedures, ablating 14 hepatomas and 51 liver metastases. In 10 cases the treatment was repeated twice. Tumor size ranged from 0.5 cm to 8 cm, with a mean of 2.4 cm. Open surgical approach was performed in 14 cases (24.6%), seven of which were simultaneously treated for associated diseases. Percutaneous treatment was adopted in 43 cases (75.4%). A laparoscopic approach was not tempted in any case. Morbidity was 8.8%, mostly in open surgery (4 cases or 28.6%) but in one patient (2.3%) with percutaneous approach. Difference in between the two groups was statistically significant (p=0.013). Overall mortality was 2.2%: one patients deceased for myocardial infarction. The mean length of hospital stay was of 4.1 days for the percutaneous treatment group and 7.6 days for the open surgery approach. Number of the lesions did not interfere with surgical approach. Postoperative CT control showed no differences, in terms of complete ablation of the tumor, between the two groups of patients. Advantages of percutaneous approach include less invasiveness, reduced postoperative pain, shorter hospitalization, reduced costs and lower discomfort in repeating the procedure. In addition, open surgical RFA allows better cancer staging, avoidance of adjacent organ injury, accessibility to all liver areas and gives the chance to performe simultaneous organ resection. These results are encouraging in making the percutaneous approach of RFA the method of choice in these patients.
Immunotherapy of B-Cell Lymphoma With CD3x19 Bispecific Antibodies: Costimulation via CD28 Prevents “Veto” Apoptosis of Antibody-Targeted Cytotoxic T Cells
Authors: Peter T. Daniel, Arne Kroidl, Joachim Kopp, Isrid Sturm, Gerhard Moldenhauer, Bernd Dörken, Antonio Pezzutto
Journal: Blood (1998)
Abstract 3722: Diet-induced Weight Loss Improves Myocardial Glycolysis and Glucose Oxidation Rates in Obese Humans
Authors: C H Lin, Pilar Herrero, Jasdeep Sidhu, Richard I Stein, Robert J Gropler, Samuel Klein, Deborah L Delano, Linda R Peterson
Journal: Circulation (2009)

Obesity contributes to the development of cardiac dysfunction in animal studies by excessively increasing myocardial fatty acid metabolism, which is at the expense of glucose metabolism. This dispr...
Application of RT-PCR for diagnosis of respiratory syncytial virus and human metapneumovirus infections in Bulgaria, 2006-7 and 2007-8
Authors: S Pavlova, T Hadzhiolova, P Abadjieva, R Kotseva
Journal: Eurosurveillance (2009)

We describe here the results of respiratory syncytial virus (RSV) detection by reverse transcription polymerase chain reaction (RT-PCR) during two consecutive seasons, from December 2006 to February 2007 and from October 2007 to March 2008, performed in the National Laboratory of Influenza and Acute Respiratory Diseases, Bulgaria. A total number of 278 nasopharyngeal samples obtained from hospitalised children up to the age of five years were investigated for these two seasons. During the first season, the aetiological role of RSV was confirmed in 56 of 148 samples (37.8%) compared to 11 of 130 samples (8.5%) during the second season. Since the beginning of January 2008, RT-PCR for the detection of the recently identified human metapneumovirus (HMPV) has also been introduced in Bulgaria. This virus has been demonstrated as the aetiological agent in 13 out of 81 samples (16%) from children of the same age group. The use of RT-PCR allows the detection of a broader spectrum of viruses causing respiratory diseases, as well as better discrimination of the aetiological agents in clinically similar cases.
Abstract P338: Age and Gender Differences in Response to Repeat Blood Pressure Measurement after Brief Patient Rest Period
Authors: Keerthana Karumbaiah, Bassam A Omar
Journal: Circulation (2013)

Background: Office-based blood pressure (BP) measurement is a snapshot of a patient’s ambulatory BP, and is subject to variations which may influence management. Objective: To assess the effect of age and gender on repeat BP measurement after a brief rest period in an outpatient cardiology clinic. Methods: Patient charts reviewed in University-based cardiology clinic identified 170 encounters which contained BP re-measurement data due to elevated initial BP of &gt; 130/80 mmHg. BP was measured initially by a nurse, with the patient in a sitting position and the arm resting at the level of the heart. If BP was &gt; 130/80 mmHg, it was repeated by physician after resting the patient for 15 minutes. There were 86 males (51%) and 84 females (49%); 113 (66%) elderly patients ≥ 60 years of age and 57 (34%) younger patients &lt; 60 years of age. Results: Among all encounters, after a brief rest period, initial systolic BP (SBP) of 153 ± 27 mmHg decreased to 145 ± 27 mmHg (decrease of 8 mmHg; P = 0.003), and initial diastolic BP (DBP) of 87 ± 16 mmHg decreased to 83 ± 15 mmHg (decrease of 4 mmHg; P = 0.04). SBP decreased by 8 mmHg in both males (from 156 ± 30 to 148 ± 27 mmHg) and females (from 151 ± 23 to 143 ± 14) (NS, males versus females). DBP decreased by 5 mmHg in males (from 91 ± 18 to 86 ± 18 mmHg) and by 2 mmHg in females (from 83 ± 12 to 81 ± 12 mmHg) (P = 0.04, males versus females). SBP decreased by 11 mmHg in elderly (from 154 ± 23 to 143 ± 15 mmHg) and 2 mmHg in the young (from 153 ± 33 to 151 ± 30 mmHg) (P=0.02, old versus young). DBP decreased by 3 mmHg in elderly (from 82 ± 12 to 79 ± 12 mmHg) and 4 mmHg in the young (from 97 ± 18 to 93 ± 17 mmHg) (NS, old versus young). Discussion: Hypertension is a challenging public health problem. JNC 7 guidelines recommend that prior to BP measurement, patient should be seated quietly for at least 5 minutes in a chair, with feet on the floor, and arm supported at heart level. This resulted in a significant decrease in BP in our patients. In this study we show that while males and females decrease their systolic BP to the same extent after a brief rest period, males have a greater drop in their diastolic BP than females. Moreover, after the rest period, patients ≥ 60 years of age drop their systolic BP greater than patients &lt; 60 years of age, while there was no significant difference in the drop of their diastolic BP. Given the high reported prevalence of White-coat hypertension in the elderly, between 15% and 25%, this is a clinically significant observation that reinforces that physicians should remeasure the blood pressure, especially the subset of males and the elderly, in whom a bigger decrement may be detected in blood pressure measurement after a brief rest period.
Abstract P187: Gender Equality and female-to-male Smoking Ratio: Trends in Spain Over the Last 50 Years (1960-2010)
Authors: Paula Beltran, Usama Bilal, Ana Navas-Acien, Esteve Fernández, Francisco Bolumar, Manuel Franco
Journal: Circulation (2013)

INTRODUCTION Gender empowerment has been associated with higher gender smoking ratio (GSR) and proved to be a strong predictor of the GSR. Our aim is to study how changes in gender equality may be associated with female-to-male smoking ratio trends in Spain over the last 50 years. HYPOTHESIS We hypothesize that greater gender equality will increase female-to-male gender smoking ratio. METHODS Values of the United Nations Development Programme’s Gender Inequality Index (GII) were calculated in 5-year intervals from 1960-2010, using data from the National Institute of Statistics. The GII ranges from 0-1 (1 meaning highest inequality) and contemplates 3 dimensions: reproductive health (measured by maternal mortality ratio and adolescent fertility rate), empowerment (share of parliamentary seats and % of each gender with at least secondary education), and female and male labor force participation rates. Female and male smoking prevalence and female-to-male smoking ratio were measured by retrospective reconstruction of National Health Surveys conducted in 2001, 2003, 2006, 2009 (n=20.426, n=21.358, n=29.478, n=22.188), attending to smoking initiation and cessation dates and birth cohorts. In order to test the association between the GII and GSR over the 5 decades we performed Pearson’s correlation. FINDINGS The GII decreased from 0.65 to 0.09 in Spain in the last 50 years. Higher women’s empowerment (parliamentary representation: from 0% to 36%; attainment of secondary education: from 5% to 63%), higher women’s participation in the labor force (from 19% to 68%), and lower maternal mortality ratio (from 45.36 to 4.11 deaths/100.000 live births), can account for most of the reduction in the GII. The smoking prevalence reconstruction reproduced the model of the epidemic in developed countries. Women born after 1951 had a smoking prevalence pattern similar to men’s, as opposed to women born prior to this date. GSR increased from 0.05 to 0.66, indicating that smoking prevalence of both genders converged in time. A gradient of the GSR by level of education was observed and women with higher education had equal smoking prevalence compared to men since 1990. The relation between the GII and GSR over time resulted inversely proportional (r=-0.99) with decreases in gender inequality relating to higher female-to-male smoking ratio. CONCLUSIONS We found a strong negative correlation between gender inequality and female-to-male smoking ratio. Gender equality has significantly improved in Spain over the last 50 years and this process has been accompanied of differential smoking prevalence patterns by genders, which eventually result in analogous female and male smoking prevalence. Gender sensitive tobacco control measures specifically targeted to women are necessary to prevent female smoking prevalence from rising, especially in the context of social transitions involving women’s development.