NEW DRUGS FOR THE TREATMENT OF HYPERTENSION
Authors: R W WILKINS
Journal: Annals of Internal Medicine (1959)

Article1 January 1959NEW DRUGS FOR THE TREATMENT OF HYPERTENSIONROBERT W. WILKINS, M.D., F.A.C.P.ROBERT W. WILKINS, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONSince 1950 a number of new antihypertensive drugs have come into use and have helped to change not only our clinical management but also our basic concepts of essential hypertension. These drugs have in common only their antihypertensive property, and even this is mediated differently by each of them. Thus the ganglionic blocking drugs reduce the activity of the sympathetic nervous system, the veratrum products stimulate the depressor activity of the parasympathetic nervous system, theRauwolfiaderivatives lessen the pressor effects of central nervous agitation, hydralazine dilates the arteriolar system, particularly in the kidney, and chlorothiazide augments natruresis, and... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Presented at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 29, 1958.From the Robert Dawson Evans Memorial, Massachusetts Memorial Hospitals, and the Department of Medicine, Boston University School of Medicine, Boston, Massachusetts.Requests for reprints should be addressed to Robert W. Wilkins, M.D., Professor of Medicine, Boston University School of Medicine, Boston, Massachusetts. 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A second report from the European Working Party on high blood pressure in the elderly (EWPHE)Adverse Effects of Antihypertensive Drug Therapy on Glucose IntolerancePrevention of the Glucose Intolerance of Thiazide Diuretics by Maintenance of Body-PotassiumEffects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: Studies in vitroDie Anwendung von Diuretika bei der akuten und chronischen HerzinsuffizienzHypokalemia and diabetes mellitusThiazide-induced disturbances in carbohydrate, lipid, and potassium metabolismSide Effects of DiureticsDiuretics as Antihypertensive AgentsImpairment of glucose tolerance produced by diuretics and other drugsHaemodynamic and electrocardiographic effects of frusemide during supine exercise in patients with angina pectoris.Symptomatic Diabetes Mellitus Cured by Potassium and Withdrawal of Polythiazide in a Hypokalemic Hypertensive WomanIMPAIRMENT OF GLUCOSE METABOLISM DURING TREATMENT WITH ANTIHYPERTENSIVE DRUGSGLUCOSE INTOLERANCE DURING DIURETIC THERAPYChanges in the Fasting Blood Sugar After Hydrochlorothiazide and Potassium SupplementationChemically and Hormonally Induced DiabetesDETERIORATION OF GLUCOSE TOLERANCE IN HYPERTENSIVE PATIENTS ON PROLONGED DIURETIC TREATMENTDer experimentelle DiabetesDie Sekretion des Insulins. 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