A Case of Sickle Cell Disease with an Abscess Arising in an Infarct of the Liver
Authors: HERVEY P. BRITTAIN
Journal: Annals of Internal Medicine (1966)

Case Studies1 September 1966A Case of Sickle Cell Disease with an Abscess Arising in an Infarct of the LiverHERVEY P. BRITTAIN, M.D., ANGEL DE LA TORRE, M.D., EDWARD N. WILLEY, M.D.HERVEY P. BRITTAIN, M.D.Search for more papers by this author, ANGEL DE LA TORRE, M.D.Search for more papers by this author, EDWARD N. WILLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-3-560 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAbnormalities of hepatic function are frequently observed in patients with sickle cell hemoglobinopathy (1-5). Such abnormalities include increased direct-acting serum bilirubin, bilirubinuria, urobilinogenuria, decreased Bromsulphalein® excretion, increased serum alkaline phosphatase, increased serum glutamic oxaloacetic transaminase, prolonged prothrombin time, hypoalbuminemia, hyperglobulinemia, and increased cephalin flocculation or thymol turbidity tests. These manifestations of hepatic dysfunction appear to be due to hepatic ischemia caused by obstruction of sinusoids by sickled red cells (1, 3, 6, 7). Both in biopsy and in autopsy material intralobular necrosis and scattered confluent lobular infarcts have been reported by various authors (1, 2, 3, 7). Extensive confluent lobular...References1. BOGOCHCASSELMANMARGOLIESBOCKUS AWGMPHL: Liver disease in sickle cell anemia. Amer. J. Med. 19: 583, 1955. CrossrefMedlineGoogle Scholar2. GREENCONLEYBERTHRONG TWCLM: Liver in sickle cell anemia. Bull. Hopkins Hosp. 92: 99, 1953. MedlineGoogle Scholar3. OWENALDRIDGETHOMPSON DMJERB: Unusual hepatic sequela of sickle cell anemia. Report of five cases. Amer. J. Med. Sci. 249: 175, 1965. CrossrefMedlineGoogle Scholar4. WADE FA: Sickle cell crisis resembling obstructive (cholangiolar type) jaundice. Report of a case and review of the literature. Virginia Med. Monthly 87: 474, 1960. MedlineGoogle Scholar5. DIGGS LW: Sickle cell crises. Amer. J. Clin. Path. 44: 1, 1965. CrossrefGoogle Scholar6. WALTERS JH: Vascular occlusion in sickle cell disease. Proc. Roy. Soc. Med. 51: 646, 1958. MedlineGoogle Scholar7. KIMMELSTIEL P: Vascular occlusion and ischemic infarction in sickle cell disease. Amer. J. Med. Sci. 216: 11, 1948. CrossrefMedlineGoogle Scholar8. HUGGINSPOST CJ: Experimental subtotal ligation of the arteries supplying the liver. Arch. Surg. (Chicago) 35: 878, 1937. CrossrefGoogle Scholar9. LICHTMAN SS: Disease of The Liver, Gallbladder and Bile Ducts, 3rd ed. Lea & Febiger, Philadelphia, 1953, p. 1007. Google Scholar10. PASS IJ: Infarction of the liver. Amer. J. Path. 11: 503, 1935. MedlineGoogle Scholar11. DIGGS LW: Pathology of sickle cell anemia. Southern Med. J. 27: 839, 1934. CrossrefGoogle Scholar12. HUGHESCARROLL JGDS: Salmonella osteomyelitis complicating sickle cell disease. Pediatrics 19: 184, 1957. MedlineGoogle Scholar13. RAHIMTOOLAGOODDAVIES SCJPD: Pulmonary infarction in disorders associated with the sickle cell trait. Thorax 15: 320, 1960. CrossrefMedlineGoogle Scholar14. RYWLINBENSON AMJ: Massive necrosis of the spleen with formation of a pseudocyst. Report of a case in a white man with sickle cell trait. Amer. J. Clin. Path. 36: 142, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HERVEY P. BRITTAIN, M.D.; ANGEL DE LA TORRE, M.D.; EDWARD N. WILLEY, M.D.Affiliations: Jacksonville, FloridaFrom Duval Medical Center, Jacksonville, Fla.Dr. de la Torre is a Research Fellow in Medicine, J. Hillis Miller Health Center, Gainesville, Fla., under graduate training grant 2TI-HE-5493 from the National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Edward N. Willey, M.D., Department of Pathology, Duval Medical Center, Jacksonville, Fla. 32206. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAn Hepatic Abscess in a Patient With Sickle Cell AnemiaLiver Abscesses in Children: A Single Center Experience in the Developed WorldPercutaneous drainage of hepatic abscessess in childrenHepatic Biloma Complicating Sickle Cell DiseaseCryptogenic hepatic abscess in two uncompromised childrenHepatic infarction in ulcerative colitis during pregnancyPyogenic liver abscess. 1 September 1966Volume 65, Issue 3Page: 560-563KeywordsHemoglobinopathiesHepatocytesHyperglobulinemiaIschemiaLiverNecrosisPhosphatasesProthrombin timeSerum glutamic oxaloacetic transaminaseSickle cell disease ePublished: 1 December 2008 Issue Published: 1 September 1966 PDF downloadLoading ...