tbuckley/cabot-search huggingface dataset:
Screening for melanoma
Authors: P. Little, M. Keefe, J. White
Journal: BMJ (1995)

striking and highly significant improvement in the clinical outcome at three months was observed in the nimodipine limb.Among all 554 patients, 235 of whom underwent operation, a bleeding event led to nimodipine being stopped in only one patient.This patient suffered a colonic bleed of moderate severity, which the investigator reported as possibly being associated with nimodipine.The patient required a blood transfusion but recovered uneventfully."Bleeding" events were reported as an adverse event in two further patients, both of whom had received nimodipine.The first patient was reported to have a rash and haematoma on the back, which the investigator stated was almost certainly related to the use of ceftazidine.The second patient was reported as having thrombocytopenia and anaemia.This was observed 15 days after the treatment with nimodipine was completed, and the investigator reported that these adverse events were possibly related to atenolol, which the patient was receiving at the time.Thus the data from the British aneurysm nimodipine trial give little support to the findings reported by Wagenknecht and colleagues, which are possibly artefacts, reflecting the authors' post hoc analyses.
Notes on Health Resorts: Llandrindod Wells
Authors: R. Saundby
Journal: BMJ (1900)

of febrile patients, and finally, prognosis and signs of im- provement are also reviewed.Though perhaps most suitable for medical practitioners and nurses who have cases under their care, the book may also be useful as a guide to the intelligent patient.In La Peste et son Microbe (Paris: Georges Carr6 et C. Naud.I900.Crown 8vo, pp.124.Fr. 4), Professor NETTER gives an excellent summary of the recent discoveries on plague, com- mencing with the places which have been invaded with plague since I874, and the discovery of the East African and Trans- Balkalian endemic centres.He then passes on to a descrip- tion of the plague bacillus, treating of its morphological and cultural characters, action on animals, and its behaviour out- side the body in the corpse, soil, dust, and water.The section on the symptoms, course, and diagnosis of plague is as important as is that on the etiology and prophylaxis of the disease.The last chapter is devoted to the subjects of serumtherapy and vaccination.The volume is concisely put together, and will form a very useful guide to the practitioner.
Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes
Authors: Joseph P. Tiano, Viviane Delghingaro-Augusto, Cedric Le May, Suhuan Liu, Meenakshi K. Kaw, Saja S. Khuder, Martin G. Latour, Surabhi A. Bhatt, Kenneth S. Korach, Sonia M. Najjar, Marc Prentki, Franck Mauvais-Jarvis
Journal: Journal of Clinical Investigation (2011)

The failure of pancreatic β cells to adapt to an increasing demand for insulin is the major mechanism by which patients progress from insulin resistance to type 2 diabetes (T2D) and is thought to be related to dysfunctional lipid homeostasis within those cells. In multiple animal models of diabetes, females demonstrate relative protection from β cell failure. We previously found that the hormone 17β-estradiol (E2) in part mediates this benefit. Here, we show that treating male Zucker diabetic fatty (ZDF) rats with E2 suppressed synthesis and accumulation of fatty acids and glycerolipids in islets and protected against β cell failure. The antilipogenic actions of E2 were recapitulated by pharmacological activation of estrogen receptor α (ERα) or ERβ in a rat β cell line and in cultured ZDF rat, mouse, and human islets. Pancreas-specific null deletion of ERα in mice (PERα–/–) prevented reduction of lipid synthesis by E2 via a direct action in islets, and PERα–/– mice were predisposed to islet lipid accumulation and β cell dysfunction in response to feeding with a high-fat diet. ER activation inhibited β cell lipid synthesis by suppressing the expression (and activity) of fatty acid synthase via a nonclassical pathway dependent on activated Stat3. Accordingly, pancreas-specific deletion of Stat3 in mice curtailed ER-mediated suppression of lipid synthesis. These data suggest that extranuclear ERs may be promising therapeutic targets to prevent β cell failure in T2D.
Abstract 217: Vitamin E forms induce apoptosis, necrosis, and autophagy and caused accumulation of sphingolipid intermediates in human colon cancer cells
Authors: Xiayu Rao, Qing Jiang
Journal: Cancer Research (2010)

Abstract Emerging evidence by us and others suggests that certain forms of vitamin E may be promising chemoprevention agents. Here we systemically investigated the effect and mechanism of different forms of vitamin E on the growth and death of human colon cancer HT29 and HCT116 cells. γ-tocopherol (γT), δ-tocopherol (δT), and γ-tocotrienol (γTE) inhibited the proliferation of HT29 and HCT116 cells in a time- and dose-dependent manner, with the potency of γTE &amp;gt; δT &amp;gt; γT. HCT116 cells appeared to be more sensitive to the treatment than HT29 cells. Studies using annexin V and propidium iodide staining revealed that γT (50 µM) and γTE (20 µM) induced externalization of phosphatidylserine and enhanced permeability of the plasma membrane, indicating apoptosis and necrosis. On the other hand, none of the treatments activate caspase-3 and PARP except in HCT116 by γTE at 20 µM. Interestingly, γT, δT and γTE enhanced expression of microtubule-associated protein light chain-3 II (LC3 II) in both HT29 and HCT116 cells, suggesting that these vitamin E forms may induce autophagy. Consistently, electromicroscopic results showed that after 14-h treatment, γTE (20 µM) induced extensive formation of autophagic vacuoles with intact cytoplasmic membrane and little induction of chromatin condensation in HCT116. Myriocin, a specific inhibitor of serine palmitoyltransferase, a key enzyme in de novo synthesis of sphingolipids, partially protected HT29 and HCT116 cells from γTE-induced cell death. Importantly, γTE caused marked accumulation of dihydrosphingosine and dihydroceramide but not ceramide or sphingosine as early as after 8-hour incubation. Because dihydrosphingosine is shown to be a potent inducer of cell death, these findings demonstrated that vitamin E may induce apoptosis, autophagy and necrosis in colon cancer cells by modulation of sphingolipid synthesis pathway. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 217.
Nuclear Factor of Activated T Cells (NFAT)-dependent Transactivation Regulated by the Coactivators p300/CREB-binding Protein (CBP)
Authors: Carmen García-Rodríguez, Anjana Rao
Journal: The Journal of Experimental Medicine (1998)

p300 and cAMP response element–binding protein (CREB)–binding protein (CBP) are members of a family of coactivators involved in the regulation of transcription and chromatin. We show that transcription factors of the nuclear factor of activated T cells (NFAT) family bind p300/CBP and recruit histone acetyltransferase activity from T cell nuclear extracts. The NH2-terminal transactivation domain of NFAT1 and the phospho-CREB- and E1A-binding sites of p300/CBP are involved in the interaction. The viral oncoprotein E1A inhibits NFAT-dependent transactivation in a p300-dependent manner. Recruitment of the coactivators p300/CBP by the transactivation domains of NFAT proteins is likely to play a critical role in NFAT-dependent gene expression during the immune response.
Practicing Medicine in Difficult Times: Protecting Physicians From Malpractice Litigation
Authors: Alan G. Williams
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostic Indicators in Metastatic Prostate Cancer
Authors: William E. Powers
Journal: JAMA (1991)

<h3>To the Editor. —</h3> In reading the article by Chodak et al,<sup>1</sup>I was surprised to find that neither the differentiation nor the Gleason score of the tumors was considered in the analysis. Many physicians have the impression from clinical experience that patients with a high Gleason score or a poorly differentiated adenocarcinoma will have a poorer response to hormone manipulation than patients with more well-differentiated tumors. Since I expect that the data are available for each patient, I wonder if such an analysis has been or could be performed by this group.
Potential use of fucose-appended dendrimer/α-cyclodextrin conjugates as NF-κB decoy carriers for the treatment of lipopolysaccharide-induced fulminant hepatitis in mice
Authors: Chiho Akao, Takahiro Tanaka, Risako Onodera, Ayumu Ohyama, Nana Sato, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima
Journal: Journal of Controlled Release (2014)
A JURY OF TWELVE MEDICAL MEN.
Authors: EPHRAIM CUTTER
Journal: JAMA (1894)

In the March 17, 1894, number of thisJOURNAL, John A. Sterling, Esq., ably treats "The Medical Expert Witness," On page 378, column 2, line 46, he writes: "If it were possible to have a jury of twelve medical men in all cases where medical evidence is required, then the medical expert would be unnecessary." I think not, but that he would be needed more than under our present American system of medical jurisprudence, which for more than a generation has been an<i>opprobrium medicoram</i>. This opprobrium can not be changed because the bar does not want it. Well do I remember the efforts made some thirty years ago to change this system, which were led by my late honored and honorable teacher, Prof. R. E. Rogers of the University of Pennsylvania. Probably there never was a more eloquent lecturer in a medical college. He made the dry subject of
Intracardiac Pacing of Electrographs Via CVP Line
Authors: Donald J. Weber
Journal: JAMA (1973)

To the Editor.—  Postoperatively, the patient who has had open-heart surgery is prone to arrhythmias, intraventricular conduction defects, and heart block. A precise evaluation of certain arrhythmias can be difficult or impossible. Recordings from epicardial ventricular pacing wires are not helpful in analyzing the atrial mechanism, and the use of esophageal leads is unpleasant and subject to artifact. Veins are often at a premium, but central venous pressure lines are generally in place in or near the superior vena cava. A 240-gauge polyethylene catheter (internal diameter 0.066 inches) will easily admit a 4F semifloating pacemaking catheter. Using sterile precautions and a doubleended wire connector to the V lead of a properly grounded electrocardiographic machine, an intra-atrial and usually an intraventricular electrograph can be obtained within a minute or two.  Atrial flutter was readily diagnosed in a patient postoperatively, with a ventricular rate of 140 beats per minute showing a left
Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development
Authors: Steven W. Lane, Serena De Vita, Kylie A. Alexander, Ruchan Karaman, Michael D. Milsom, Adrienne M. Dorrance, Amy Purdon, Leeann Louis, Mary L. Bouxsein, David A. Williams
Journal: Blood (2011)
Amino acids and amines stimulate gastrin release from canine antral G-cells via different pathways.
Authors: J DelValle, T Yamada
Journal: Journal of Clinical Investigation (1990)

The major determinant of meal-stimulated gastric acid secretion is the antral hormone gastrin. Decarboxylated amine derivatives of amino acids have been proposed as the final common mediators of gastrin secretion stimulated by a meal. We explored the cellular basis for this hypothesis using a recently developed isolated canine G-cell model. Both amino acids and, more potently, their corresponding amines, directly stimulated gastrin release. Amino acid-stimulated gastrin secretion was unaffected by decarboxylase inhibitors (alpha methyldopa, aminooxyacetic acid, and 4-deoxypyridoxine) but enhanced by bombesin, isobutylmethylxanthine, and dibutyryl cAMP. Somatostatin inhibited amino acid-stimulated gastrin release via a pertussis toxin-sensitive GTP-binding protein. In contrast, gastrin secretion induced by amines was unaltered by any of the various treatments. Our data indicate that amino acids and amines, either as primary constituents of an ingested meal or as metabolites of dietary proteins, act directly via separate mechanisms to stimulate gastrin secretion from G-cells.
OPTIMIZING CROSSOVER FROM TICAGRELOR TO CLOPIDOGREL IN PATIENTS WITH ACUTE CORONARY SYNDROME: THE CAPITAL OPTI-CROSS RANDOMIZED TRIAL
Authors: Ali Pourdjabbar, Benjamin Hibbert, Trevor Simard, F Daniel Ramirez, Peter Lugomirski, Ronnen Maze, Marino Labinaz, Aun-Yeong Chong, Alexander Dick, Chris Glover, Michael Froeschl, Jean-Francois Marquis, George Wells, Michel Le May, Derek So
Journal: Journal of the American College of Cardiology (2015)
Increased Airway Vascularity in Newly Diagnosed Asthma Using a High-magnification Bronchovideoscope
Authors: Hiroshi Tanaka, Gen Yamada, Toyohiro Saikai, Midori Hashimoto, Shintaro Tanaka, Kazuhiko Suzuki, Masaru Fujii, Hiroki Takahashi, Shosaku Abe
Journal: American Journal of Respiratory and Critical Care Medicine (2003)

Hypervascularity in the bronchial wall is part of airway remodeling, but has remained an ill-defined process in asthma pathogenesis. Previous morphologic assessment has been limited to biopsy specimens, and therefore a high-magnification bronchovideoscope (side-viewing type) was developed for less invasive examination of subepithelial vessels. We evaluated vascularity in the lower trachea, using this novel scope in 12 normal control subjects, 13 patients with chronic obstructive pulmonary disease, and 24 subjects with stable asthma; 8 were steroid naive with newly diagnosed asthma (Group A) and 16 had been treated with inhaled corticosteroids for more than 5 years (Group B). The redness of bronchial mucosa in patients with asthma observed by conventional fiberoptic bronchoscopy proved to be due to a fine vascular network. Morphometric measurements of subepithelial vessels showed that both vessel area density and vessel length density were significantly (p<0.0001) increased in subjects with asthma as compared with control subjects and patients with chronic obstructive pulmonary disease. The degree of increase in vessels did not differ between Group A and Group B. The increase in subepithelial vessels of the airway is present even in newly diagnosed asthma. This novel bronchovideoscope is useful for assessment of vessel network in the surface of the airway lumen in vivo.
An Inhibitory Spinal Cord Neuron
Authors: Elaine A. Neale
Journal: JAMA (1980)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Results of treating primary tumours of the trachea by irradiation.
Authors: A Y Rostom, R L Morgan
Journal: Thorax (1978)

Forty-four patients presented with primary tumours of the trachea over a 25-year period. Thirty-nine of them were treated by irradiation. Of these, 24 (61.5%) died as a result of their disease while 30% are either alive and well (4.4-11 years) or have died of intercurrent disease (average four years). Recurrences or metastases when they occurred were in the first two years after diagnosis in all but one patient, who developed local recurrence 3.25 years later. Three patients died of unknown cause (average 5.6 years) after irradiation. Two factors seem to determine the prognosis: the histology and the extent of disease on presentation. Dysphagia without oesophageal involvement carried a grave prognosis.
Relief of Neurological Symptoms and Signs by Reconstruction of a Stenosed Internal Carotid Artery
Authors: C. Edwards, C. Rob
Journal: BMJ (1956)

PERINATAL MORTALITYBpo=H 1265 cranial birth trauma have been used, and the value of distinguishing such cases from the intra-partum asphyxia group is stressed.A diagnosis of prematurity or previability is considered undesirable, and was made in only 2 % of the present series.The clinical associations of each category are enumerated, and the aetiology is discussed.In most cases there was a specific association between a given patho- logical group or groups and at least one feature of pregnancy or labour.Thus, the classification is not merely academic, but should also be of practical value to the obstetrician and paediatrician.It is felt that the general adoption of such a system throughout the country would assist the collation of valid statistics on the causes of perinatal mortality.In addition to the classification of death, certain factors in pregnancy and labour have been re-examined in order to determine in what way and at which stage they cause foetal and neonatal loss.Finally, a study has been made of some clinical aspects of babies dying in the first week of life.The pulmonary syndrome of the newborn, birth trauma, pneumonia, and intraventricular haemorrhage, which together caused two-thirds of the neonatal deaths, could not usually be distinguished during life.Successful prophylaxis of pneumonia during the latter part of the period covered by this study is described.
Emotional aspects of mental time travel
Authors: Arnaud D'Argembeau, Martial Van der Linden
Journal: Behavioral and Brain Sciences (2007)

Abstract We consider three possible reasons why humans might accord a privileged status to emotional information when mentally traveling backward or forward in time. First, mental simulation of emotional situations helps one to make adaptive decisions. Second, it can serve an emotion regulation function. Third, it helps people to construct and maintain a positive view of the self.
8. Potent Inhibition of HIV-1 Replication by Lentiviral Vectors Carrying Anti-Vif siRNA
Authors: S. Li, G. Wang, K. Meinking, M. J. Li, J. Ji, J. A. Zaia, J. J. Rossi
Journal: Molecular Therapy (2005)

Small inhibitory RNAs (siRNAs) inhibit HIV replication by promoting sequence-specific degradation of genomic and sub-genomic HIV-1 RNA. Lentiviral vectors are able to transduce a wide array of quiescent cell types with sustained long-term expression of the transgenes. RNA polymerase III (pol III) provides an ideal means of expressing small RNA in human cells.
TCT-296 Comparison of Zotarolimus-Eluting stents versus Everolimus –Eluting stents versus Sirolimus-Eluting and in Patients with Long Coronary Artery Lesions Assessed by Volumetric Intravascular Ultrasound Analysis
Authors: Young-Rak Cho, Jung-Min Ahn, Soo-Jin Kang, Young-Hak Kim, Won-Jang Kim, Jong-Young Lee, Woo Seok Lee, Gyung-Min Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2012)
Circumcision programme to prevent AIDS in Africa is starting to slow down
Authors: A. Gulland
Journal: BMJ (2014)

Six million men have had medical circumcisions to prevent the transmission of HIV in 14 countries in sub-Saharan Africa, but the programme is beginning to slow down, according to a collection of papers published in PLOS One and PLOS Medicine. 1

The papers look at the success and challenges of the programme and find that while 5.8 million to 6 million medical circumcisions had been done between 2008 and the end of 2013, progress in countries varies widely and the year on year rate of growth in the number of procedures performed is beginning to decline. The number of procedures increased by 109% compared with the previous year in 2011, by 93% in …
Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice.
Authors: Y Kawabe, A Ochi
Journal: The Journal of Experimental Medicine (1990)

The cellular basis of the in vitro and in vivo T cell responses to Staphylococcus enterotoxin B (SEB) has been investigated. The proliferation and cytotoxicity of V beta 8.1,2+,CD4+ and CD8+ T cells were observed in in vitro response to SEB. In primary cytotoxicity assays, CD4+ T cells from control spleens were more active than their CD8+ counterparts, however, in cells derived from SEB-primed mice, CD8+ T cells were dominant in SEB-specific cytotoxicity. In vivo priming with SEB abrogated the response of V beta 8.1,2+,CD4+ T cells despite the fact that these cells exist in significant number. This SEB-specific anergy occurred only in V beta 8.1,2+,CD4+ T cells but not in CD8+ T cells. These findings indicate that the requirement for the induction of antigen-specific anergy is different between CD4+ and CD8+ T cells in post-thymic tolerance, and the existence of coanergic signals for the induction of T cell anergy is suggested.
Disassociation of intrinsic and haemodynamic responses in stenotic arteries
Authors: W. P Santamore, K. S Li
Journal: Cardiovascular Research (1993)

Journal Article Disassociation of intrinsic and haemodynamic responses in stenotic arteries Get access William P Santamore, William P Santamore Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Louisville, Louisville, KY 40202, USA: W P Santamore; Philadelphia Heart Institute, Presbyterian Medical Center, Philadelphia, Pennsylvania, USA: K S Li. Correspondence to Dr Santamore. Search for other works by this author on: Oxford Academic PubMed Google Scholar Kun S Li Kun S Li Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Louisville, Louisville, KY 40202, USA: W P Santamore; Philadelphia Heart Institute, Presbyterian Medical Center, Philadelphia, Pennsylvania, USA: K S Li. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 11, November 1993, Pages 2058–2064, https://doi.org/10.1093/cvr/27.11.2058 Published: 01 November 1993 Article history Received: 12 May 1993 Accepted: 13 July 1993 Published: 01 November 1993