tbuckley/cabot-search huggingface dataset:
Disease Activity in Systemic Lupus Erythematosus Correlates With Expression of the Transcription Factor AT‐Rich–Interactive Domain 3A
Authors: Julie M. Ward, Kira Rose, Courtney Montgomery, Indra Adrianto, Judith A. James, Joan T. Merrill, Carol F. Webb
Journal: Arthritis & Rheumatology (2014)

Objective Systemic lupus erythematosus (SLE) is a complex and multifactorial autoimmune disease with striking clinical, immunologic, and genetic heterogeneity, despite nearly ubiquitous antinuclear antibody (ANA) production. Multiple gene polymorphisms have been associated with the disease, but these individually account for only a very small percentage of overall SLE risk. In earlier studies, constitutive expression of the DNA‐binding protein AT‐rich–interactive domain 3A (ARID3a) in transgenic mouse B lymphocyte lineage cells led to spontaneous ANA production and preferential development of B cells associated with production of polyreactive antibodies. Therefore, we undertook this study to determine whether ARID3a was overexpressed in B lymphocytes of SLE patients and whether ARID3a expression was associated with disease severity. Methods A cross‐section of SLE patients, rheumatoid arthritis patients, and age‐ and sex‐matched controls was analyzed longitudinally for lupus disease activity, numbers of ARID3a+ peripheral blood mononuclear B cells from multiple B cell subsets, and immunoglobulin and cytokine levels. Results Fifty of 115 SLE patients (43%) had dramatically increased numbers of ARID3a+ B cells compared to healthy controls. ARID3a was not expressed in naive B cells of healthy controls, but was abundant in these precursors of antibody‐secreting cells in SLE patients. Total numbers of ARID3a+ B cells correlated with increased disease activity as defined by SLE Disease Activity Index scores in individuals assessed at 3 time points. Conclusion These findings identify B cell anomalies in SLE that allow stratification of patient samples based on ARID3a expression and implicate ARID3a as a potential marker of CD19+ B lymphocytes correlated with disease activity.
Ginkgo and Memory
Authors: Pradeep J. Nathan, Ben J. Harrison, Cali Bartholomeusz
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NONREPLACEMENT OPERATIONS FOR MITRAL VALVE REGURGITATION
Authors: Chiwon Hahn, MD, Gus J. Vlahakes, MD
Journal: Annual Review of Medicine (1997)

▪ Abstract Mitral valve reconstruction offers patients an important alternative to the traditional method for treating severe mitral regurgitation—mitral valve replacement. Over the last 15 years, surgical techniques have evolved for treating mitral regurgitation occurring from various anatomic mechanisms—annular dilatation, abnormal leaflet motion due to a variety of causes, or leaflet perforation. Currently, over 90% of regurgitant mitral valves of varying etiologies are amenable to nonreplacement therapy by reconstruction, with good intermediate- and long-term results. Reconstruction obviates the need for long-term anticoagulation, and thus, there has evolved a trend toward reconstruction earlier in the course of this disease, before fixed atrial fibrillation and ventricular dilatation occur.
Inequality and women's mental health: an overview
Authors: Elaine H. Carmen, Nancy F. Russo, Jean B. Miller
Journal: American Journal of Psychiatry (1981)

Complex processes of sex bias and sex-role stereotyping continue to detract from the quality of mental health services to both sexes, but particularly to women because of their disadvantaged status. Understanding how such processes can simultaneously create barriers to service access and facilitate inappropriate treatment is essential to ensuring quality mental health services. Ameliorating the problems of women as providers and consumers in the mental health delivery system will require a sophisticated understanding of the nature of those problems and a firm commitment to creative solutions. The ethical mandate to address the institutional structures of inequality extends to all persons who are part of the mental health delivery system.
Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling
Authors: Wei-Ming Fu, Xiao Zhu, Wei-Mao Wang, Ying-Fei Lu, Bao-Guang Hu, Hua Wang, Wei-Cheng Liang, Shan-Shan Wang, Chun-Hay Ko, Mary Miu-Yee Waye, Hsiang-Fu Kung, Gang Li, Jin-Fang Zhang
Journal: Journal of Hepatology (2015)
Diagnostic yields of a combination use of multi-guided devices in the basis of the obtained data from virtual bronchoscopic navigation LungPoint system using thin video-bronchoscope for small (≤30 mm) peripheral pulmonary lesions
Authors: Masafumi Misawa, Motohisa Takai, Yu Munakata, Haruki Kobayashi, Kei Nakashima, Naoko Katsurada, Hideki Makino, Norihiro Kaneko, Masahiro Aoshima
Journal: European Respiratory Journal (2013)

Background:  Guided bronchoscopy has been gradually notable because of its contribution to increasing the diagnostic yields for small peripheral pulmonary lesions (PPLs). Virtual bronchoscopic navigation (VBN) has been fundamental equipment for that reason in Japan. We have been consistently used this navigation software LungPoint (Broncus Tech, USA) since it was gone on sale in Japan.  Objective:  We aimed to furthermore increase of diagnostic yields for small (≤30 mm) PPLs by diverse approach in the basis of the LungPoint data using thin-bronchoscope (Olympus, Japan)  Methods:  Between October 2010 and January 2013, a new diagnostic technique was performed for 132 patients (136 lesions) at our hospital. All of the patients had small PPLs suspected lung cancer with diameters of 30 mm or less as determined by chest CT scan. We used the obtained data from LungPoint such as VB-image, navigating pathway to determine how to approach to the target. The other guided-devices such as 20-MHz mechanical radial-type probe EBUS (RP-EBUS) and a guide sheath (GS) (Olympus, Japan) were used in combination case by case. Primary endpoint was overall diagnostic yields.  Results:  The variation of a combination procedure was VBN/VBN-EBUS/VBN-EBUS-GS. The number of each case was 35/45/56. The overall diagnostic yields of 132 cases (136 PPLs) were 79%.  Conclusions:  A new combination technique via thin-bronchoscope following the data from LungPoint was useful to determine what devices we should choice for approaching to the target and increase diagnostic yields for small PPLs.
Tumor-infiltrating CD163-positive macrophages, clinicopathological parameters, and prognosis in classical Hodgkin lymphoma
Authors: P. Kamper, K. Bendix, S. Hamilton-Dutoit, B. Honoré, F. d'Amore
Journal: Journal of Clinical Oncology (2009)

8528 Background: Classical Hodgkin lymphoma (cHL) is characterized by a minority of neoplastic cells surrounded by a heterogeneous background of non-neoplastic cells. A possible prognostic role of LAMs in cHL and follicular lymphomas has been suggested. CD163 is a haemoglobin scavenger receptor expressed by monocytes/macrophages. A high CD163 expression has been observed in macrophages belonging to the “alternative activation” pathway suggested to have pro-tumoral effect. The aim of the present study was to correlate the expression of the tumor-infiltrating CD163+ LAMs with clinico-pathological features and prognosis in a cohort of previously untreated HL patients (pts). Methods: A tissue microarray (TMA) was constructed with paraffin embedded tissue specimens from 286 cHL cases. CD163 expression was assessed immunohistochemically and the degree of intratumoral LAM infiltration was scored semi-quantitatively. Clinical data were obtained from the Danish population-based lymphoma registry and clinical records. All pts were homogeneously treated with either chemo-radiotherapy (localised disease) or ABVD chemotherapy (advanced disease). Results: The median age was 37 yrs (range: 6–86 yrs). The M:F ratio was 1.2. The histological subtypes were: nodular sclerosis (NS)-type I, 167 cases (59 %); NS-type II, 71 (25%); mixed cellularity (MC), 44 (15 %); lymphocyte-rich, lymphocyte-depleted and cHL-NOS, each one case. Of 253 pts with assessable International Prognostic Score (IPS), 204 had a low-risk (≤ 2) and 49 a high risk (&gt;2) profile. A high number of tumour-infiltrating CD163+ cells was associated with a significantly poorer overall and event-free survival (p=0.029 and p=0.018, respectively). Furthermore, a high expression of CD163 strongly correlated to stage IV disease (p=0.035), presence of B-symptoms (p=0.008), lymphocytopenia (p=0.003), hypersedimentation (p=0.009). In a multivariate analysis, IPS score &gt; 2 remained the strongest predictor. Conclusions: In cHL, a high number of intratumoral CD163+ monocytes/macrophages correlates with adverse outcome and with clinical parameters reflecting underlying aggressive disease biology. No significant financial relationships to disclose.
265 DEVELOPMENT OF A LIVER-SPECIFIC, TUMOUR-SELECTIVE RECOMBINANT ADENO-ASSOCIATED VIRUS VECTOR TO TARGET HEPATOCELLULAR CARCINOMA
Authors: M. Della Peruta, C. Binny, D. Nathwani, J. McIntosh, C. Rosales, A.M. Davidoff, R. Williams, S. Chokshi, A.C. Nathwani
Journal: Journal of Hepatology (2012)
Abstract 14000: ApoB-100 Related Peptide Vaccine Reduces Hypertension and Mortality in a Model of Angiotensin II-Induced Aortic Aneurysm in Apo E (-/-) Mice: A Novel Therapeutic Paradigm
Authors: Tomoyuki Honjo, Paul C Dimayuga, Kuang-Yuh Chyu, Xiaoning Zhao, Jianchang Zhou, Juliana Yano, Wai Man Lio, Portia Trinidad, Bojan Cercek, Prediman K Shah
Journal: Circulation (2011)

Background: Aortic aneurysms (AA) are characterized by increased oxidative stress with chronic immune-mediated inflammation of the aortic wall. We recently demonstrated that immunization with apoB-...
COPD exacerbation severity is associated with impaired macrophage phagocytosis of eosinophils
Authors: Osama Eltboli, Mona Bafadhel, Neeta Kulkarni, Christopher Brightling
Journal: European Respiratory Journal (2013)

Background: COPD is associated with a sputum eosinophilia in 10-20% of subjects. Cytoplasmic red hue of sputum macrophages is an indirect measure of macrophage phagocytosis of eosinophils. We sought to determine if there are clinical characteristics that differentiate COPD subgroups determined by their sputum eosinophil and macrophage red hue and whether the severity of exacerbations is different between these groups.

Methods: 100 subjects were recruited and categorised into 4 groups by sputum eosinophil count ( 3%) and sputum macrophage red hue median % area ( 6%).

Results: There were no differences in lung function or exacerbation frequency between the 4 groups A: high red hue, high sputum eosinophils (n=13); B: low red hue, low sputum eosinophils (n=19); C: low red hue, high sputum eosinophil (n=10); D: high red hue, low sputum eosinophils (n=58). Positive bacterial culture was lower in groups A and C (p=0.01). The change in FEV1 at exacerbation compared with stable state was greatest in group C ( the % change in FEV1 in C is 21.52% (95% confidence interval [7.2-35.8] p=0.01) compared to group A, B & D respectively (10.99, 8.9, 9.7%)).

![Figure][1] 



Conclusions: Bacterial colonisation and eosinophilic inflammation in COPD rarely co-exist. Those with eosinophilic inflammation and impaired macrophage phagocytosis determined by red hue had the most severe exacerbations.

 [1]: pending:yes
Rituximab plus CHOP (R-CHOP) in the treatment of elderly patients with diffuse large B-cell lymphoma. An update of the GELA study.
Authors: B. Coiffier, C Ferme, O. Hermine, C. Haioun, E Baumelou, P. Solal-Celigny, A. Delmer, C. Sebban, N. Mounier, G Tertian, A. Van Hoof, André Bosly
Journal: Blood (2001)
Abstract 1934: Predictors of Long-Term Success Following Balloon Angioplasty of Native Coarctation
Authors: Matthew A Studer, Mark A Law, Michael D Taylor, Henri Justino, Ronald G Grifka, Charles E Mullins, Michael R Nihill
Journal: Circulation (2006)

BACKGROUND: Balloon angioplasty (BA) of native coarctation (CoA) is an accepted therapy, however, long-term results and predictors of success are limited. OBJECTIVES: To examine the long-term outco...
Is operant selectionism coherent?
Authors: François Tonneau, Michel B. C. Sokolowski
Journal: Behavioral and Brain Sciences (2001)

Hull et al.'s analysis of operant behavior in terms of interaction and replication does not seem consistent with a genuine selection model. The putative replicators do not replicate, and the overall process is more reminiscent of directed mutation than of natural selection. General analogies between natural selection and operant reinforcement are too superficial to be of much scientific use.
Association of asthma exacerbation with objective and subjective assessments of occupational exposure
Authors: Paul Henneberger, Xiaoming Liang, Linnéa Lillienberg, Anna Dahlman-Höglund, Kjell Torén, Eva Andersson
Journal: European Respiratory Journal (2014)

Background: Researchers commonly use job-exposure matrices (JEMs) and self-reports to characterize occupational exposures in epidemiologic studies of respiratory diseases. JEMs provide more objective assessments than self-reports, but the latter are easy to collect and have performed well in some studies. We investigated whether one of these exposure estimates had a stronger association with severe exacerbation of asthma in a study of adults with asthma.  Methods: We used data from a telephone survey of 557 working adults with asthma in the eastern United States. Severe exacerbation was defined as having had at least 2 events with unplanned care or hospitalization for asthma in the 12 months before interview, and occupational exposure was determined for the same time period using both a recently-developed asthma-specific JEM and self-reports of being exposed to dust, smoke, gas, or chemical fumes at work. We used regression to model severe exacerbation and examine exposure-exacerbation relationships while controlling for potential confounders.  Results: Occupational exposure was assessed as present for 254 using the JEM and 334 by self-reports, and the two groups overlapped by 175. Twenty-seven percent (n=150) fulfilled the criteria for severe exacerbation. The contrast in frequency of severe exacerbation for exposed versus unexposed was greater with the JEM (31% vs 23%, p=0.05) than self-reports (28% vs 25%, p=0.57), and this difference persisted after controlling for sex and education.  Conclusion: Occupational exposures assessed using a JEM had a stronger association with severe exacerbation of asthma than self-reported exposures.
Glucocorticoids enhance CCL20 release in bronchial epithelial cells in a metalloprotease-dependent manner
Authors: Jan Zijlstra, Dennie Rozeveld, Nick ten Hacken, Antoon van Oosterhout, Irene Heijink
Journal: European Respiratory Journal (2011)

Glucocorticoid (GC) insensitivity is a major clinical problem in the management of asthma. Although a potential role for Th17 cells has been described in GC insensitive asthma, it is still unknown why GCs are unable to efficiently suppress Th17-mediated inflammation. CCL20 acts as a potent chemoattractant for Th17 cells. To determine the effect of GCs on CCL20 secretion and to unravel the underlying regulatory mechanisms, we examined the effect of budesonide and fluticasone (10-7-10-10M) on TNF-α-induced CCL20 and IL-8 production (ELISA and qPCR) in 16HBE human bronchial epithelial cells and primary bronchial asthma epithelium. We used specific inhibitors for the ERK, p38, STAT3 and PI3K pathways, the GC-receptor (GR), protein synthesis and a general metalloprotease inhibitor.

Surprisingly, we observed that GCs do not suppress, but enhance the release of CCL20 in by 16HBE cells, under conditions where IL-8 was efficiently suppressed. Importantly, GCs also induced a substantial increase in the TNF-α-induced release of CCL20 in asthma epithelium. Although the TNF-α-induced CCL20 release was dependent on the ERK, p38 and STAT3 pathways, the upregulation by GCs was not blocked by their inhibition. Furthermore, our data demonstrate that the effect of GC is mediated by GR activation, which is likely mediated at posttranslational level in a metalloprotease-dependent manner.

Thus, we show for the first time that GCs enhance metalloprotease-dependent release of CCL20, which may constitute a novel mechanism of Th17-mediated GC insensitive neutrophilic airway inflammation in asthma and provide new opportunities for therapeutic intervention.
Expression of mRNA for Gastrin-Releasing Peptide Receptor by Human Bronchial Epithelial Cells
Authors: JILL M. SIEGFRIED, MARY ANN A. DeMICHELE, JAY D. HUNT, AUTUMN GAITHER DAVIS, KUNWAR P. VOHRA, JOSEPH M. PILEWSKI
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

Bombesin-like peptides (BLPs) are important regulators of lung development and may also act as autocrine growth factors in lung tumors. We have previously demonstrated expression of mRNA for the three BLP receptor subtypes (neuromedin B [NMB] receptor, gastrin-releasing peptide [GRP] receptor, and bombesin receptor subtype 3 [BRS-3]) in human non-small cell lung carcinoma (NSCLC) cell lines and bronchial biopsies using the reverse transcription-polymerase chain reaction (RT-PCR; DeMichele, et al. Am. J. Respir. Cell Mol. Biol. 1994;11:66–74). We have also previously found that growth responses to BLPs could be elicited in some, but not all, cultures of human bronchial epithelial (HBE) cells (Siegfried, et al. Anat. Rec. 1993;236:241–247). In this report, we utilized RT-PCR to demonstrate mRNA expression of BLP receptor subtypes in cultured HBE cells and also assessed the response of these cultures to BLPs in proliferation assays. The pattern of mRNA expression was correlated with proliferative response, and the results were also analyzed in relation to smoking history and pulmonary function of the subjects studied. Our results suggest that expression of mRNA for the GRP receptor is associated with a long smoking history ( > 25 pack-years [PY], p = 0.02). This association was related to past tobacco exposure, regardless of whether the subjects were still active smokers at the time of tissue procurement. Responsiveness to GRP and NMB in proliferation assays was also found only in those HBE cultures with expression of mRNA for at least one of the known receptors for BLPs, and there was a significant association between expression of mRNA for the GRP receptor and proliferative response to both GRP and NMB (p = 0.048). HBE cultures from subjects with a greater than 25 PY smoking history were also more likely to respond to BLPs in the proliferation assays than cells from subjects with less than a 25 PY history (10 of 16 versus 1 of 7, p = 0.06). Cultures of HBE cells from four of the five subjects with severe obstructive lung disease gave a positive response to GRP and NMB in proliferation assays, compared to five of fifteen without severe obstructive lung disease, but this difference was not significant (p = 0.13). These results suggest there is an increased likelihood of expression of the GRP receptor mRNA in the respiratory epithelium of some individuals with a history of prolonged tobacco exposure, and that expression of the GRP receptor mRNA is accompanied by responsiveness to the mitogenic effects of BLPs. These effects appear to persist after smoking cessation.
Capsazepine inhibits NF-κB subunits in dsRNA-exposed human bronchial epithelial cells from asthmatic and COPD donors
Authors: Irma Mahmutovic Persson, Angelica Brandelius, Leif Bjermer, Jenny Calvén, Yuliana Yudina, Lena Uller
Journal: European Respiratory Journal (2011)

Background:  Novel drugs are needed to treat viral-induced exacerbations of asthma and COPD. We have shown that capsazepine (CPZ) inhibits viral-induced cytokine production (including thymic stromal lymphopoietin, TSLP) in human asthmatic bronchial epithelial cells (HBEC) more effectively than steroids.   Objective:  Investigate NF-κB mechanisms potentially involved in actions of CPZ in HBECs from patients with asthma and COPD.   Methods:  Primary HBEC were obtained by fibre optic bronchoscopy from individuals with asthma (n=6) and COPD (n=3), then grown in 12-well plates and stimulated with viral surrogate dsRNA (10 μg/ml) to induce pro-inflammatory cytokine (TSLP, TNF-α, IL-8, IFN-β) mRNA expression (RT-qPCR) and production (ELISA). CPZ (3-30 μM) was added 1 h prior to dsRNA. NF-κB-signaling was studied (western blot) using specific antibodies for NF-κB subunits p65, p105 and IκB-α. De novo gene synthesis of IκB-α was studied by RT-qPCR.   Results:  dsRNA induced marked expression and release of TSLP, TNF-α, IL-8, and IFN-β (p   Conclusion:  CPZ effectively reduced dsRNA-induced cytokine overproduction in HBECs from asthmatic and COPD donors. CPZ inhibited dsRNA-induced IκB-α degradation preventing dissociation and translocation of p65 and p105 to the nuclear NF-κB promoter. CPZ may stabilize IκB-α thus inhibiting NF-κB-dependent cytokine production.
Abstract 320: Increased Expression and Activity of Phosphodiesterase-1 Isoforms in Pulmonary Artery Smooth Muscle Cells from Patients with Pulmonary Hypertension and Role in Proliferation
Authors: Fiona Murray, Ryan Y Suda, Hemal H Patel, Shen Zhang, Patricia A Thistlethwaite, Jason X Yuan, Paul A Insel
Journal: Circulation (2006)

Pulmonary artery smooth muscle cells (PASMC) from patients with idiopathic pulmonary arterial hypertension (IPAH) or secondary pulmonary hypertension (SPH) have reduced agonist-induced cAMP and inc...
Mitoxantrone versus doxorubicin in combination chemotherapy for advanced carcinoma of the breast.
Authors: R C Leonard, M A Cornbleet, S B Kaye, M Soukop, G White, A W Hutcheon, S Robinson, M E Kerr, J F Smyth
Journal: Journal of Clinical Oncology (1987)

One hundred fifteen patients with metastatic carcinoma of the breast were treated in a randomized trial of mitoxantrone (Novantrone, Lederle Laboratories, Pearl River, NY) combined with vincristine and prednisolone (VMP) or doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH) combined with vincristine and prednisolone (VAP). In 100 evaluable patients, the objective response rates were 35% for VMP and 61% for VAP, the complete response rates being 6% and 13%, respectively. In responding patients, median time to progression was 6.2 months for VMP and 7.9 months for VAP. The median survival whether measured from primary diagnosis, first metastasis, or from the start of chemotherapy was similar for both regimens. Toxicity, particularly alopecia, was appreciably lower in the VMP treated patients, but subclinical cardiotoxicity was seen within the scheduled dosage for both combinations. We conclude that VAP is clearly more active, but clinically more toxic than VMP. There is no survival advantage conferred by the more toxic combination. Cardiac toxicity is a potential hazard with either drug combination.