THE USE OF DEMEROL IN PATIENTS WITH BRONCHIAL ASTHMA
Authors: J A HERSCHFUS, A SALOMON, M S SEGAL
Journal: Annals of Internal Medicine (1954)

Article1 March 1954THE USE OF DEMEROL IN PATIENTS WITH BRONCHIAL ASTHMAJ. A. HERSCHFUS, M.D., A. SALOMON, M.D., M. S. SEGAL, M.D., F.A.C.P.J. A. HERSCHFUS, M.D.Search for more papers by this author, A. SALOMON, M.D.Search for more papers by this author, M. S. SEGAL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-3-506 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSoon after the discovery of a new group of analgesic compounds in 1939,1 one of these, 1-methyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester hydrochloride, was intensively investigated. This drug is generally known under the name of Demerol, meperidine, Dolantin, Pethidine or Isonipecaine, and its chemical structure is shown in figure 1.Pharmacologic investigations showed that Demerol has a weak atropine-like and a stronger papaverine-like action on smooth muscle2; these actions were demonstrable on spastic or stimulated smooth muscle. Schaumann1, 3also demonstrated spasmolytic action on intestinal or bronchial smooth muscle whether contraction was caused by a cholinergic drug, by nerve stimulation or by...Bibliography1. EislebSchaumann OO: Dolantin, ein neuartiges Spasmolytikum und Analgetikum, Deutsch. med. Wchnschr. 65: 967, 1939. CrossrefGoogle Scholar2. YonkmanNothHecht FFPHHH: Demerol: a new synthetic analgetic spasmolytic and sedative agent. I. Pharmacologic studies, Ann. Int. Med. 21: 7, 1944. LinkGoogle Scholar3. 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PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGENERAL ANESTHETICS AND ADJUVANTSPATHOGENESIS OF PULMONARY HYPERTENSION; BRONCHIAL ASTHMA AND BRONCHIECTASISThe Asthmatic Narcotic AddictThe Role of Chlorpromazine in the Treatment of Bronchial Asthma and Chronic Pulmonary EmphysemaCare of the Patient With Chronic Pulmonary DiseaseRELAXANTS AND THE HUMAN CARDIO-VASCULAR SYSTEM 1 March 1954Volume 40, Issue 3Page: 506-515KeywordsAnalgesicsAsthmaCholinergicsDrugsHospital medicineNervesSmooth muscles Issue Published: 1 March 1954 PDF downloadLoading ...