tbuckley/cabot-search huggingface dataset:
Abstract 2522: Angiotensin Converting Enzyme Inhibitor is the Only Drug that Slows the Progression of Aortic Stenosis among First-line Antihypertensive Agents
Authors: Kana Wakabayashi, Tsujino Takeshi, Goda Akiko, Shinji Nakao, Naito Yoshiro, Misato Otsuka, Mika Matsumoto, Chikako Yoshida, Masaaki Lee, Tsuyoshi Sakoda, Mitsumasa Ohyanagi, Yasushi Sakata, Kazuhiro Yanamoto, Thoru Masuyama
Journal: Circulation (2007)

Background: E pidemiological studies suggested that hypertension is one of the risk factors of non-rheumatic aortic stenosis (AS). However, the effect of antihypertensive agents on the progression of AS is unclear. Statin is only a drug whose effect on the progression of AS was examined in randomized controlled trials, but there are conflicting results. Objectives: To examine the effect of first-line antihypertensive agents such as angiotensin converting enzyme inhibitor (ACEI), angiotensin II type 1 receptor blocker (ARB), diuretics, beta-blocker, and calcium channel blocker (CCB) on the progression of AS. We also examined whether statin use affected the progression of AS. Methods: We studied 293 consecutive patients (from Feb 2005 to Mar 2007, aged 71±10 years, 153 females) with native valves with peak aortic flow velocity (AFV) ≥2.0 m/sec in whom 2 or more echocardiograms were done with an interval of at least 6 months in echo lab of Hyogo Collage of Medicine and Osaka University Hospital. We reviewed ...
MicroRNAs Regulating Signaling Pathways: Potential Biomarkers in Systemic Sclerosis
Authors: Yisha Li, Jing Huang, Muyao Guo, Xiaoxia Zuo
Journal: Genomics Proteomics & Bioinformatics (2015)

Abstract Systemic sclerosis (SSc) is a multisystem fibrotic and autoimmune disease. Both genetic and epigenetic elements mediate SSc pathophysiology. This review summarizes the role of one epigenetic element, known as microRNAs (miRNAs), involved in different signaling pathways of SSc pathogenesis. The expression of key components in transforming growth factor-β (TGF-β) signaling pathway has been found to be regulated by miRNAs both upstream and downstream of TGF-β. We are specifically interested in the pathway components upstream of TGF-β, while miRNAs in other signaling pathways have not been extensively studied. The emerging role of miRNAs in vasculopathy of SSc suggests a promising new direction for future investigation. Elucidation of the regulatory role of miRNAs in the expression of signaling factors may facilitate the discovery of novel biomarkers in SSc and improve the understanding and treatment of this disease.
Liver Tumors Induced by a New Beta-Adrenoreceptor Blocking Agent in Female Rats&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Authors: G Ragnotti, M Presta, L Riboni, T Zavanella
Journal: JNCI Journal of the National Cancer Institute (1982)

A newly synthesized beta-adrenoreceptor blocking agent, DL-1-(2-nitro-3-methyl-phenoxy)-3-tert-butylamino-propan-2-ol (ZAMI 1305), administered intragastrically for 6 months induced hepatocellular carcinomas in female outbred Wistar rats in a dose-dependent fashion but was harmless to the livers of male outbred Wistar rats. Experiments with castrated animals confirmed the dependence of the carcinogenic effect of ZAMI 1305 on the hormonal status of the rat. When an isomer of ZAMI 1305, DL-1-(2-nitro-5-methyl-phenoxy)-3-tert-butylamino-propan-2-ol (ZAMI 1327), and DL-practolol, which have pharmacologic activities similar to those of ZAMI 1305, were administered by the same experimental technique as used for ZAMI 1305, no liver tumors appeared either in male or female rats.
Novel Systemic Therapies for Small Cell Lung Cancer
Authors: Charles M. Rudin, Christine L. Hann, Craig D. Peacock, D. Neil Watkins
Journal: Journal of the National Comprehensive Cancer Network (2008)

A diagnosis of small cell lung cancer (SCLC) today confers essentially the same terrible prognosis that it did 25 years ago, when common use of cisplatin-based chemotherapy began for this disease. In contrast to past decades of research on many other solid tumors, studies of combination chemotherapy using later generation cytotoxics and targeted kinase inhibitors have not had a significant impact on standard care for SCLC. The past few years have seen suggestions of incrementally improved outcomes using standard cytotoxics, including cisplatin-based combination studies of irinotecan and amrubicin by Japanese research consortia. Confirmatory phase III studies of these agents are ongoing in the United States. Antiangiogenic strategies are also of primary interest and are in late-phase testing. Several novel therapeutics, including high-potency small molecule inhibitors of Bcl-2 and the Hedgehog signaling pathway, and a recently discovered replication-competent picornavirus, have shown remarkable activity against SCLC in preclinical models and are currently in simultaneous phase I clinical development. Novel therapeutic approaches based on advances in understanding of the biology of SCLC have the potential to radically change the outlook for patients with this disease.
Phase I trial of everolimus and gemcitabine for patients with solid tumors refractory to standard therapy and for a cohort of patients with cholangiocarcinoma/gallbladder cancer.
Authors: B. A. Costello, Y. Qi, M. J. Borad, G. P. Kim, D. W. Northfelt, C. Erlichman, S. R. Alberts
Journal: Journal of Clinical Oncology (2010)

TPS166 Background: Everolimus, an mTOR inhibitor, and gemcitabine, a novel pyrimidine antimetabolite, have activity in a variety of cancers as single agents. The combination of the two drugs may provide a meaningful new treatment option for patients with cancer. The goals of this study are to: (1) determine the maximally tolerated dose (MTD) of concurrently administered everolimus and gemcitabine in patients with advanced, refractory solid tumors; (2) describe the toxicity of the treatment combination; (3) describe any evidence of the antitumor activity of the treatment combination; (4) obtain pilot data on toxicity and efficacy outcomes in patients with cholangiocarcinoma or gallbladder carcinoma. Methods: Main eligibility criteria include (1) age ≥ 18 years old; (2) histologic proof of cancer that is now unresectable and refractory to or refused all standard treatment for the disease; (3) ECOG Performance Status (PS) 0, 1, or 2; (4) for the MTD cohort, histologic proof of metastatic cholangiocarcinoma or gallbladder carcinoma. This is a single-arm phase I study designed to determine the MTD of everolimus plus gemcitabine. Depending on dose-escalation level, everolimus is administered at 5 mg orally 3x/week, 5mg daily, or 10mg daily. Gemcitabine dosing ranges from 600 to 1,000 mg/m2 intravenously, given on days 1 and 8. Cycle length is 21 days. MTD is defined as the dose level below the lowest dose that induces dose-limiting toxicity in at least one-third of patients. We anticipate an accrual rate of 1 patient/week. The dose-escalation phase of this study may involve a maximum of 30 patients but will likely require only 18 patients. Therefore, the study duration will range from a minimum of 36 weeks to a maximum of 60 weeks. Then, 10 patients with cholangiocarcinoma or gallbladder carcinoma will be enrolled at the MTD. This cohort will accrue over a maximum of 20 weeks. The primary endpoint is to determine the MTD and toxicity profile of the combination. No correlative studies are planned. Thus far, six patients have been enrolled in the dose escalation phase. Two patients are off active treatment due to disease progression. Supported in part by Novartis. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Amgen, Bristol-Myers Squibb, Genentech, sanofi-aventis
Trends in Mortality From Cancer, With Special Reference to Gastric Cancer in Iceland&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Julius Sigurjonsson
Journal: JNCI Journal of the National Cancer Institute (1966)

Revised statistics on cancer mortality in Iceland, back to 1921, were obtained by examination of all individual death records, with the cancer deaths recoded according to the Seventh Revision of the International Classification of Diseases after cases of incomplete site specification were checked against annual lists of cancer patients. These lists were compiled by the district physicians, beginning with 1932. Further information was sought on all cases of cancer of the ventricle occurring from 1938-60. The records indicated that stomach cancer had not been overdiagnosed to any noteworthy extent. No real increase was found in the over-all mortality from cancer during the period under investigation, the increase in standardized rates being explainable by underreporting of old people in the earlier decades. The mortality from gastric cancer is still unusually high in Iceland, though a definite downward trend has been observed in recent years. While the standardized rates for gastric cancer in both sexes are appreciably lower than those in japan and Chile, the rate for males is higher than in any other country in Western Europe and the rate For Females is matched only by those rates for females in Finland and Austria.
A Transplantable Granular Cell Myoblastoma in Strain C3H Mice
Authors: Thelma B. Dunn, Arleigh W. Green
Journal: JNCI Journal of the National Cancer Institute (1965)

Neoplasms having the histologic features of granular cell myoblastomas in man were found in the uterine cervix of estrogen-treated mice. One of these was successfully transplanted and is now in the fourth generation. The transplants grow slowly, and only a small percentage were successfully transplanted in the early generations. In the second generation, 16 months after transfer, one mouse had a tumor 2 cm in diameter that was composed of both granular cell myoblastoma tissue and areas of malignant fibroblasts. Another mouse, 20 months after transfer from the same tumor, had a nodule in the right flank, with the gross features of a granular cell myoblastoma, and a second discrete nodule in the left flank, diagnosed as a fibrosarcoma. The possible relationship between the two types of malignant tissue is discussed, and the transplantation history and histologic descriptions of the tumors are given.
Dynamics of adaptive and innate immunity in patients treated during primary human immunodeficiency virus infection: results from Maraviroc in HIV Acute Infection (MAIN) randomized clinical trial
Authors: M Ripa, M Pogliaghi, S Chiappetta, L Galli, S Pensieroso, M Cavarelli, G Scarlatti, S De Biasi, A Cossarizza, D De Battista, M Malnati, A Lazzarin, S Nozza, G Tambussi
Journal: Clinical Microbiology and Infection (2015)
Characterization of two epithelial cell air-liquid interface (ALI) culture models for human healthy nasal mucosa and nasal polyps
Authors: Francisco de Borja Callejas, Asunción Martínez-Antón, Jordi Roca-Ferrer, Mireya Fuentes, Nuria Cortadellas, Julio Cortijo, Cesar Picado, Joaquim Mullol
Journal: European Respiratory Journal (2013)

Background: Primary human airway epithelial cells cultured in an air-liquid interface (ALI) develop a well-differentiated, polarized, and pseudostratified epithelium. Objective: To obtain and characterize human nasal mucosa and nasal polyp well-differentiated epithelia using an ALI culture system. Methods: Epithelial cells were obtained from 7 nasal mucosa (NM) and 9 nasal polyps (NP), and differentiated in ALI culture during 28 days. At different times (0, 7, 14, 21, and 28 days) were performed: ultrastructure study by electron microscopy (SEM, TEM); mucous and serous secretion by ELISA; cytokines and chemokines analysis by CBA (Cytometric Bead Array); and β-tubulin IV (cilia marker), MUC5AC (goblet cell marker) and p63 (basal cell marker) expression by immunocytochemistry. Results: In both NM and NP ALI cultures, pseudostratified epithelium with ciliated, mucus-secreting, and basal cells were observed by SEM and TEM at days 14 and 28. Displaying epithelial cell re-differentation, β-tubulin IV (ciliated cells) and MUC5AC (goblet cells) positive cells increased while p63 (basal cells) positive cells decreased overtime. In NP cultures MUC5AC secretion increased overtime compared to day 0 (100%), being significantly (p
Efficacy and Safety of Perioperative Chemotherapy with 5Fu-Cisplatin-Cetuximab in Gastric and Gastroesophageal Junction Adenocarcinomas (Ggoja): a Single Arm Multicentre Phase Ii Trial (Ffcd 0901)
Authors: C. Mariette, G. Piessen, C. Monterymard, D. Pezet, A. Ferru, M. Baconnier, X. Adhoute, D. Tavan, C. Lepage, O. Bouché
Journal: Annals of Oncology (2014)
Social Class Differences Among Patients With Large-Bowel Cancer in Cali, Colombia&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: W Haenszel, P Correa, C Cuello
Journal: JNCI Journal of the National Cancer Institute (1975)

The incidence of large-bowel cancer in Cali, Colombia, for 1962-71 shows the upper socioeconomic classes to be a higher risk. This is the first report of a socioeconomic gradient in risk for this site. The gradients were most marked for cancer of the ascending through rectosigmoid colon and were minimal for cancer of the cecum and rectum. The Cali experience presents several parallels with information derived from comparisons of developed and developing countries and also appears consistent with recent information on the possible role of dietary factors in bowel cancer.
Prevalence of Posttraumatic Stress Disorder in Vietnam-Era Women Veterans
Authors: Kathryn Magruder, Tracey Serpi, Rachel Kimerling, Amy M. Kilbourne, Joseph F. Collins, Yasmin Cypel, Susan M. Frayne, Joan Furey, Grant D. Huang, Theresa Gleason, Matthew J. Reinhard, Avron Spiro, Han Kang
Journal: JAMA Psychiatry (2015)

Many Vietnam-era women veterans served in or near war zones and may have experienced stressful or traumatic events during their service. Although posttraumatic stress disorder (PTSD) is well studied among men who served in Vietnam, no major epidemiologic investigation of PTSD among women has been performed.To assess (1) the onset and prevalence of lifetime and current PTSD for women who served during the Vietnam era, stratified by wartime location (Vietnam, near Vietnam, or the United States), and (2) the extent to which wartime location was associated with PTSD, with adjustment for demographics, service characteristics, and wartime exposures.Survey of 8742 women who were active-duty military personnel in the US Armed Forces at any time from July 4, 1965, through March 28, 1973, and alive as of survey receipt as part of Department of Veterans Affairs Cooperative Study 579, HealthVIEWS. Data were obtained from mailed and telephone surveys from May 16, 2011, through August 5, 2012, and analyzed from June 26, 2013, through July 30, 2015.Lifetime and current PTSD as measured by the PTSD module of the Composite International Diagnostic Interview, version 3.0; onset of PTSD; and wartime experiences as measured by the Women's Wartime Exposure Scale-Revised.Among the 4219 women (48.3%) who completed the survey and a telephone interview, the weighted prevalence (95% CI) of lifetime PTSD was 20.1% (18.3%-21.8%), 11.5% (9.1%-13.9%), and 14.1% (12.4%-15.8%) for the Vietnam, near-Vietnam, and US cohorts, respectively. The weighted prevalence (95% CI) of current PTSD was 15.9% (14.3%-17.5%), 8.1% (6.0%-10.2%), and 9.1% (7.7%-10.5%) for the 3 cohorts, respectively. Few cases of PTSD among the Vietnam or near-Vietnam cohorts were attributable to premilitary onset (weighted prevalence, 2.9% [95% CI, 2.2%-3.7%] and 2.9% [95% CI, 1.7%-4.2%], respectively). Unadjusted models for lifetime and current PTSD indicated that women who served in Vietnam were more likely to meet PTSD criteria than women who mainly served in the United States (odds ratio [OR] for lifetime PTSD, 1.53 [95% CI, 1.28-1.83]; OR for current PTSD, 1.89 [95% CI, 1.53-2.33]). When we adjusted for wartime exposures, serving in Vietnam or near Vietnam did not increase the odds of having current PTSD (adjusted ORs, 1.05 [95% CI, 0.75-1.46] and 0.77 [95% CI, 0.52-1.14], respectively).The prevalence of PTSD for the Vietnam cohort was higher than previously documented. Vietnam service significantly increased the odds of PTSD relative to US service; this effect appears to be associated with wartime exposures, especially sexual discrimination or harassment and job performance pressures. Results suggest long-lasting mental health effects of Vietnam-era service among women veterans.
Late-breaking abstract: Do emissions from animal farms affect the airways of neighboring residents?
Authors: Lidwien A.M. Smit, Annemieke W.J. Opstal-van Winden, Femke van der Sman-de Beer, Mariette Hooiveld, Johan Beekhuizen, Inge M. Wouters, Joris IJzermans, Dick Heederik
Journal: European Respiratory Journal (2011)

Concerns about public health risks of intensive animal production in The Netherlands continue to rise, in particular related to outbreaks of infectious diseases such as Q-fever. An increased risk of asthma among neighboring residents is a specific concern raised by general practitioners (GPs) in areas with high animal densities. The aim was to study respiratory health effects among individuals living in the vicinity of animal farms.  Electronic medical record data for the year 2009 of all patients of 27 GPs in a region with a high density of animal farms were used. Density of animal farms around the home address was calculated using a Geographic Information System. Associations between farm exposure variables and respiratory diseases were analyzed in 22.406 children (0-17 y) and 70.142 adults (18-70 y), adjusting for age, sex, and household income. During the study period, a Q-fever outbreak occurred in this region. “Possible Q-fever” was defined as a diagnosis of pneumonia or other infectious disease – the diagnosis code used by GPs for registration of suspected Q-fever.  Proximity to farms and modeled farm-related particulate matter (PM10) exposure were inversely associated with asthma, COPD, upper respiratory tract infections, and hay fever, whereas the same farm exposure variables were positively associated with possible Q-fever (all P  Both protective and adverse health effects among individuals living near animal farms were observed. These findings should be confirmed with diagnostic measures before firm conclusions can be drawn.
First-time treatment with steroids in bronchial asthma: comparison of the effects of inhaled beclomethasone and of oral prednisone on airway function, bronchial reactivity and hypothalamic-pituitary-adrenal axis
Authors: W Wilmsmeyer, D Ukena, TO Wagner, GW Sybrecht
Journal: European Respiratory Journal (1990)

In a double-blind cross-over study of 12 asthmatic patients the effects of 1,000 micrograms.day-1 beclomethasone dipropionate (BDP) on airway function, bronchial reactivity and hypothalamic-pituitary-adrenal (HPA) axis have been compared to those of 15 mg.day-1 oral prednisone (PRD). None of the patients had ever received corticosteroids before. Fourteen days treatment with either of both steroids improved airway function, both subjectively and objectively. Both steroids slightly reduced the responsiveness to histamine. PRD suppressed the corticotrophin-releasing factor (CRF) stimulated cortisol release more than BDP did, whereas there was no significant change in adrenocorticotrophic hormone (ACTH) release. The results indicate that short-term treatment with 1,000 micrograms.day-1 BDP reduces bronchial hyperreactivity (BHR) in asthmatic patients, whilst having subtle effects on HPA axis.
Abstract 2824: Circulating tumor cells (CTCs) can predict survival and response to treatment in non-metastatic colorectal cancer (CRC): Correlation between flowcytometry, quantitative real-time pcr (qPCR) and cytomorphology
Authors: Abeer Bahnassy, Abdel-Rahman N. Zekri, Salem E. Salem, Marwa Mohamad, Marwa Mohanad
Journal: Cancer Research (2014)

Abstract Background: Circulating tumor cells (CTCs) were detected in patients with metastatic epithelial malignancies using different methodologies. The number of CTCs before and during treatment of advanced CRC is an independent predictor of poor response to treatment, progression-free (PFS) and overall survival (OS). We investigated 1) whether CTC count can predict outcome in patients with CRC and 2) the utility of FCM supplemented with PCR and/or cyto-morphology (CM) in enumerating CTCs. Methodology: CTCs were enumerated in 56 CRC cases and 20 normal controls (NC) by flowcytometry (FCM), and quantitative real time PCR (qPCR) using CK19, MUC, CD44, CD133 and ALDH1after immune-magnetic separation. Results were correlated to cytomorphology, standard prognostic factors, overall and progression free survival (OS&amp;PFS). Results: CTCs &amp;lt; 3 were detected in 45% of the cases compared to 55% with ≥3 CTCs. CK19, MUC1, CD44, CD133 and ALDH1-RNA expression was detected in (55.4%, 44.6%, 53.6%, 43.6%, 46.4%; respectively). The concordance between FCM&amp; qPCR, FCM&amp;CM, qPCR&amp; CM ranged from 82% to 96%. Significant correlations were reported between CTCs and tumor stage and grade (p&amp;lt;0.01). OS was significantly associated with pathological tumor type, T stage, lymph nodes involvement, CTC, CK, MUC1, CD44 and CD133. PFS was significantly associated with pathological tumor type, disease stage, N stage, CTC, CK, MUC1, CD44 and CD133 (p=). Conclusions:1)enumeration of CTCs, pre- and after initial treatment, can predict outcome in CRC patients, 2)FCM is a sensitive, rapid and easy technique for enumeration of CTCs, especially if supplemented with qPCR for detection of CRC cells biomarkers (CK19), MUC, CD44, CD133 and ALDH1). Citation Format: Abeer Bahnassy, Abdel-Rahman N. Zekri, Salem E. Salem, Marwa Mohamad, Marwa Mohanad. Circulating tumor cells (CTCs) can predict survival and response to treatment in non-metastatic colorectal cancer (CRC): Correlation between flowcytometry, quantitative real-time pcr (qPCR) and cytomorphology. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2824. doi:10.1158/1538-7445.AM2014-2824
Fetal antigen 1, a member of the epidermal growth factor superfamily, in neurofibromas and serum from patients with neurofibromatosis type 1
Authors: None Jensen, None Schrøder, None Teisner, None Laursen, None Brandrup, None Rasmussen
Journal: British Journal of Dermatology (1999)

Fetal antigen 1 (FA1) is a 26-32 kDa glycoprotein containing six epidermal growth factor-like repeats closely related to the delta/notch/serrate proteins in Drosophila. FA1 has been shown to be involved in cell differentiation in a juxtacrine/paracrine manner. As neurofibromatosis type 1 (NF-1), also called von Recklinghausen disease, involves aberrant growth of tissues derived from the neural crest, the expression of FA1 was examined in neurofibroma skin biopsies and serum from patients with NF-1. FA1 was found in the spindle cells of all (n = 10) skin tumour specimens from adult NF-1 patients, whereas normal dermis was FA1 negative. In adults, the serum FA1 levels were significantly higher in NF-1 patients (n = 13) than in normal healthy controls (n = 177) (P = 0.037). In the group of children with NF-1 (n = 9), significantly higher serum FA1 levels were observed in those known to have complications with cerebral or spinal involvement (n = 4) (P = 0.014). The presence of FA1 in neurofibroma specimens and the elevated serum levels in patients with NF-1 suggests that FA1 may be involved in the pathogenesis of NF-1, perhaps acting as a growth promoting factor.
PI-RADS Prostate Imaging – Reporting and Data System: 2015, Version 2
Authors: Jeffrey C. Weinreb, Jelle O. Barentsz, Peter L. Choyke, Francois Cornud, Masoom A. Haider, Katarzyna J. Macura, Daniel Margolis, Mitchell D. Schnall, Faina Shtern, Clare M. Tempany, Harriet C. Thoeny, Sadna Verma
Journal: European Urology (2015)