tbuckley/cabot-search huggingface dataset:
Two-dimensional echocardiographic features of atrial septal aneurysms.
Authors: B Gondi, N C Nanda
Journal: Circulation (1981)

Aneurysms of the interatrial septum are rare. They have been associated with complications such as embolic phenomena and atrioventricular orifice obstruction. We describe two patients, one adult and one child, with atrial septal aneurysms that were diagnosed by real-time, two-dimensional echocardiography. Atrial septal aneurysms appeared as thin, localized outpouchings of the atrial septum that protruded into the right atrium and showed marked variations in their contour and size during the cardiac cycle. They could be differentiated from other intra-atrial structures such as tumor mass, large eustachian valve and intra-atrial baffle by their relatively low reflectance, relationship to the atrial septum, considerable alterations in their outline during the cardiac cycle and characteristic patterns during peripheral venous contrast echocardiography.
Abstract LB-169: Dissecting signaling pathways regulating translation in human glioblastoma
Authors: Michal Grzmil, Brian Hemmings
Journal: Cancer Research (2011)

Abstract Glioblastoma multiform (GBM) is the most common and aggressive brain tumor entity, with a median survival of approximately one year. In the last decade, genetic profiling of brain tumors has improved our understanding of gliomagenesis and proposed many targeted therapies based on molecular interference with deregulated signaling networks. In a search for novel molecular targets, our kinome-focused microarray analysis identified overexpressed MAP kinase-interacting kinase 1 (MNK1) in primary GBM and its elevated protein level was confirmed in primary GBMs and in glioma cell lines. MNKs can bind to translation initiation factor eIF4G and phosphorylate the cap-binding protein eIF4E at Ser209 that is required for its oncogenic activity. Targeting MNK1 activity in GBM cells suppressed eIF4E phosphorylation, reduced proliferation and colony formation whereas, concomitant treatment with Mnk inhibitor CGP57380 and mTOR inhibitor rapamycin resulted in an additive effect on growth inhibition and cell cycle arrest. Analysis of polysomal profiles revealed inhibition of translation in CGP57380 and rapamycin treated cells. Microarray analysis of total and polysomal RNA from MNK1-depleted GBM cells identified mRNAs involved in regulation of TGF-β pathway. The translation of SMAD2 mRNA as well as TGF-β-induced cell motility was regulated by MNK1-signaling. TGF-β pathways regulate growth of glioma-initiating cells that are involved in tumorigenesis, resistance to cancer therapies and relapse. Our most recent analysis identified high activity of MNK1 pathway in human GBM-derived spheres. Furthermore, inhibition of MNK1 activity significantly reduced formation and growth of cancer spheres. Our model of gliomasphere growth regulation via MNK1-signaling pathways together with clinical implications will be presented and discussed. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-169. doi:10.1158/1538-7445.AM2011-LB-169
Book Review Cancer of the Ovary Edited by Maurie Markman and William J. Hoskins. 442 pp., illustrated. New York, Raven Press, 1993. $125. 0-88167-970-4 Ovarian Cancer Edited by Stephen C. Rubin and Gregory P. Sutton. 498 pp., illustrated. New York, McGraw-Hill, 1993. $89. 0-07-054204-X
Authors: John J. Mikuta
Journal: New England Journal of Medicine (1993)
The psychological and social effects of myocardial infarction on wives.
Authors: R Mayou, A Foster, B Williamson
Journal: BMJ (1978)

Eighty-two wives of men suffering a first myocardial infarction were interviewed while their husbands were in hospital, and again two months and a year after they went home. The wives had substantial and persistent psychological symptoms, and the husbands' illness had continuing effects on their work, leisure and social activities, and family life and marriage, their psychosocial disability being comparable to that of the patients. Measures of psychosocial adjustment before the illness and the quality of the marriage and of family life were good predictors of outcome for the wives. The women had a major role in the patients' readjustment during convalescence, and their attitudes and behaviour as well as the general quality of family life were important determinants of the rate and extent of the patients' recovery. The wives of patients with myocardial infarction should have more practical help and advice during the hospital period, and the whole family should be given advice and help throughout the convalescence.
The Biology and Medicine of Signal Transduction.
Authors: I. MacFadzean
Journal: Cardiovascular Research (1994)

Journal Article The Biology and Medicine of Signal Transduction. Get access Ian MacFadzean Ian MacFadzean London, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 28, Issue 4, April 1994, Page 579, https://doi.org/10.1093/cvr/28.4.579b Published: 01 April 1994
Effect of Percutaneous Closure of Patent Foramen Ovale on Post-Procedural Arrhythmias
Authors: Achille Gaspardone, Arianna Giardina, Maria Iamele, Gaetano Gioffrè, Mauro Polzoni, Filippo Lamberti, Romolo Remoli, Gregory A. Sgueglia, Marco Papa, Cesare Iani
Journal: Journal of the American College of Cardiology (2013)
Na–Caexchange in the regulation of cardiac excitation–contraction coupling
Authors: H REUTER, C POTT, J GOLDHABER, S HENDERSON, K PHILIPSON, R SCHWINGER
Journal: Cardiovascular Research (2005)

Cardiac sarcolemmal Na(+)--Ca(2+) exchange is a central component of Ca2+ signaling essential for Ca2+ extrusion and contributing to a variable degree to the development of the systolic Ca2+ transient. Reports on differential gene expression of Na(+)--Ca2+ exchange in cardiac disease and the regulation of its thermodynamic equilibrium depending on intracellular gradients of ion concentrations between subcellular compartments have recently put a new complexion on Na(+)--Ca2+ exchange and its implications for excitation-contraction (E-C) coupling. Heart failure models and genetic approaches to regulate expression of the Na(+)--Ca2+ exchanger have improved our knowledge of exchanger function. Modest overexpression of the Na(+)--Ca2+ exchanger in heterozygous transgenic mice had minimal effects on E-C coupling and cardiac function. However, higher levels of Na(+)--Ca2+ exchange expression in homozygotes led to pathological hypertrophy and failure with an increased interaction between the L-type Ca2+ current and Na(+)--Ca2+ exchange and reduced E-C coupling gain. These results suggested that the Na(+)--Ca2+ exchanger is capable of modulating sarcoplasmic Ca2+ handling and at high expression levels may interact with the gating kinetics of the L-type Ca2+ current by means of regulating subsarcolemmal Ca2+ levels. Despite being a central component in the regulation of cardiac E-C coupling, a newly generated mouse model with cardiac-specific conditional knock-out of the Na(+)--Ca2+ exchanger is viable with unchanged Ca2+ dynamics in adult ventricular myocytes. Cardiac myocytes adapt well to knock-out of the exchanger, apparently by reducing transsarcolemmal fluxes of Ca2+ and increasing E-C coupling gain possibly mediated by changes in submembrane Ca2+ levels. For E-C coupling in the murine model, which relies primarily on sarcoplasmic Ca2+ regulation, this led to the suggestion that the role of Na(+)--Ca2+ exchange should be thought of as a Ca2+ buffering function and not as a major Ca2+ transporter in competition with the sarcoplasmic reticulum.
Prediction of Progression or Regression of Type A Aortic Intramural Hematoma by Computed Tomography
Authors: S. Kaji, K. Nishigami, T. Akasaka, T. Hozumi, T. Takagi, T. Kawamoto, H. Okura, H. Shono, Y. Horibata, T. Honda, K. Yoshida
Journal: Circulation (1999)

It has been reported that early surgery should be required for patients with type A aortic intramural hematoma (IMH) because it tends to develop classic aortic dissection or rupture. However, the anatomic features of type A IMH that develops dissection or rupture are unknown. The purpose of this study was to investigate the predictors of progression or regression of type A IMH by computed tomography (CT).Twenty-two consecutive patients with type A IMH were studied by serial CT images. Aortic diameter and aortic wall thickness of the ascending aorta were estimated in CT images at 3 levels on admission and at follow-up (mean 37 days). We defined patients who showed increased maximum aortic wall thickness in the follow-up CT (n=9) or died of rupture (n=1) as the progression group (n=10). The other 12 patients, who all showed decreased maximum wall thickness, were categorized as the regression group. In the progression group, the maximum aortic diameter in the initial CT was significantly greater than that in the regression group (55+/-6 vs 47+/-3 mm, P=0.001). A Cox regression analysis revealed that the maximum aortic diameter was the strongest predictor for progression of type A IMH. We considered the optimal cutoff value to be 50 mm for the maximum aortic diameter to predict progression (positive predictive value 83%, negative predictive value 100%).Maximum aortic diameter estimated by the initial CT images is predictive for progression of type A IMH.
Triple Hemisection: A Simplified Procedure for Lengthening the Achilles Tendon
Authors: Rafe Nelson Hatt, Timothy A. Lamphier
Journal: New England Journal of Medicine (1947)

ABOUT twenty years ago, a new procedure for lengthening the Achilles tendon was first employed. It is known as triple hemisection. Dr. Michael Hoke, who is believed to have been the first to use this simplified technic, did not publish his results. And yet, according to White,† "lengthening the heel cord is the commonest single operative procedure in the repertoire of most orthopedic surgeons, and the reporting of any simplification of the technique seems justified...."Our purpose in describing this operation is to reemphasize its simplicity. Excellent results have been obtained without the necessity of using the so-called "open tenoplastic . . .
Research in Medical Education
Authors: Charlene Breedlove
Journal: JAMA (1995)

The surge in managed health care organizations has profound consequences for the future of academic medical centers and for physicians' clinical education. Traditionally, physicians trained in academic medical centers had been ensured access to large numbers of patients with a wide variety of illnesses, some of whom could be observed for extended periods. Newly evolving managed care arrangements threaten to decrease the number and alter the mix of patients referred to academic medical centers, thus necessitating new training models. What impact are the new organizational forms for delivering health care having on academic health centers, faculty, and educational programs for medical students and resident physicians? InThe Journal's 1996 medical education issue, we would like to see articles reporting research on and analysis of changes in the ways physicians are being trained at all stages of the education process. Related topics in urgent need of attention include how academic
REPORT OF A CASE OF ANAPHYLACTIC SHOCK, WITH FAILURE TO DESENSITIZE BY INTRASPINAL ADMINISTRATION OF SERUM
Authors: Lewis Fox Frissell
Journal: JAMA (1918)

This case of anaphylactic shock in cerebrospinal meningitis is reported in order to record the failure of serum administered intraspinally to desensitize the patient to its intravenous administration.  The patient, a woman, aged 40, first seen by me one week after the onset of her illness, had had severe headache, with moderate temperature, at first declining and then rising, on the day when first seen, April 13. No focal meningeal symptoms had been observed. On the date of admission, April 13, her temperature was 104, pulse 90, and respiration 20. Physical examination revealed only a moderately rigid neck, absent patellar reflexes, and positive Babinski and Oppenheim reflexes on the right side. Kernig's sign was present. Lumbar puncture at 5 p. m. on the same day revealed a spinal fluid under pressure, moderately turbid, containing 810 cells per cubic millimeter, a + + + butyric acid test, and the intracellular and extracellular presence of
The Cystic Duct Syndrome
Authors: H. Jay Cozzolino
Journal: JAMA (1963)

We have studied seven patients with noncalculous partial cystic duct obstruction, a syndrome which has not been widely recognized in this country. All seven patients complained of right upper quadrant abdominal pain after meals, but routine oral cholecystography demonstrated normally-filling gallbladders without stones. Using cholecystokinin as a gallbladder stimulant in biliary drainage and cholecystography, we were able to demonstrate impaired gallbladder evacuation due to partial cystic duct obstruction in each instance. Reproduction of the patients' spontaneous pain corroborated the diagnosis. Because of the mechanical nature of the obstruction, cholecystectomy was performed in all patients, followed by lasting symptomatic relief. The term, "cystic duct syndrome" is proposed to designate this condition.
Is hepatitis B virus smarter than the immune system?
Authors: Marion Peters
Journal: Hepatology (1995)

It has been suggested that mutations within immunodominant cytotoxic T-lymphocyte (CTL) epitopes may be exploited by viruses to evade protective immune responses critical for clearance. 1-4 Viral escape could originate from passive mechanisms, such as mutations within curcial CTL epitopes, either affecting major histocompatibility complex binding or T-cell antigen receptor (TCR) recognition. Additionally, it has recently been shown that substitutions of TCR contact sites can yield analogue peptides that can still interact with the T-cell receptor but be unable to deliver a full stimulatory signal, thus inducing anergy 5 or acting as an antagonist for the TCR. 6-8 We report here that hepatitis B virus isolates derived from two chronically infected patients display variant epitopes that act as natural TCR antagonists with the capacity to inhibit the CTL response to the wild-type epitope. During natural infection, TCR antagonist mutations of CTL epitopes could contribute to the development of viral persistence, especially if the antiviral CTL response is monospecific or the epitope is strongly immunodominant.
Splenic Rupture in Infectious Mononucleosis
Authors: Joseph J. Timmes, James H. Averill, James Metcalfe
Journal: New England Journal of Medicine (1948)

RUPTURE of the spleen in infectious mononucleosis is a rare complication of a rather common disease. King,1 in 1941, presented the first authenticated case. Since then 13 additional cases have been reported.2 3 4 5 6 7 8 It is the purpose of this paper to present 2 additional cases of infectious mononucleosis complicated by splenic rupture. In 1 of these the primary pathologic process was unsuspected preoperatively. In the other the diagnosis had been established before operation was undertaken. Subsequent to splenectomy both patients recovered full health, and microscopical changes consistent with those described as occurring in infectious mononucleosis were found in both the removed . . .
Care Management for Heart Failure
Authors: Ariel Linden, Thomas Wilson
Journal: Annals of Internal Medicine (2005)

Letters1 March 2005Care Management for Heart FailureAriel Linden, DrPH, MS and Thomas Wilson, DrPH, PhDAriel Linden, DrPH, MSFrom Linden Consulting Group, Hillsboro, OR 97124, and Wilson Research, Loveland, OH 45140. and Thomas Wilson, DrPH, PhDFrom Linden Consulting Group, Hillsboro, OR 97124, and Wilson Research, Loveland, OH 45140.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-142-5-200503010-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Contrary to popular belief, the randomized, controlled trial is not bias-free. The paper by DeBusk and colleagues (1) highlights a potential threat to validity, the Hawthorne effect, that the authors do not recognize. The medical staff at the 5 Kaiser Permanente hospitals were informed of the study protocol. Considering that Kaiser Permanente is a closed system of care, we do not know if physicians behaved differently because they were aware that they would be indirectly scrutinized for the care they provided. One assessment that could provide insight into this issue would be to indicate the population-wide change ...Reference1. DeBusk RF, Miller NH, Parker KM, Bandura A, Kraemer HC, Cher DJ, et al. Care management for low-risk patients with heart failure: a randomized, controlled trial. Ann Intern Med. 2004;141:606-13. [PMID: 15492340] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Linden Consulting Group, Hillsboro, OR 97124, and Wilson Research, Loveland, OH 45140. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCare Management for Low-Risk Patients with Heart Failure Robert Frank DeBusk , Nancy Houston Miller , Kathleen Marie Parker , Albert Bandura , Helena Chmura Kraemer , Daniel Joseph Cher , Jeffrey Alan West , Michael Bruce Fowler , and George Greenwald Care Management for Heart Failure Robert F. DeBusk , Daniel J. Cher , and Helena C. Kraemer Metrics Cited ByDetermining if disease management saves money: an introduction to meta-analysisComing Together to Achieve Quality Cardiovascular Care 1 March 2005Volume 142, Issue 5Page: 386KeywordsEvidence based medicineHeart diseasesHeart failureMedical staff ePublished: 1 March 2005 Issue Published: 1 March 2005 CopyrightCopyright © 2005 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Clinical Evaluation of Cryoprecipitated Factor VIII
Authors: Laurence R. Simson
Journal: JAMA (1967)

Although there is increasing reason to believe that the pathogenesis of classical hemophilia involves much more than deficiency of a plasma clotting factor,<sup>1</sup>treatment of bleeding episodes remains firmly based upon the infusion of factor VIII.<sup>2</sup>The rationale of plasma transfusion therapy has been well defined<sup>3</sup>and assay procedures<sup>4,5</sup>have been developed which permit an accurate diagnosis of hemophilia (hemophilia A), and, in addition, enable quantitative assessment of therapy. Nevertheless, treatment of this disorder still is beset with difficulties. Large and frequent transfusions of fresh, freshfrozen, or reconstituted freeze-dried plasma are required to achieve and maintain hemostatic levels of factor VIII. Daily transfusions approximating one third of the patient's circulating plasma volume are required over a period of weeks to control hemorrhage following surgical procedures. Such massive plasma transfusions present the concomitant risk of circulatory overload. Moreover, prolonged plasma therapy limits the mobility of the patient
ABSCESS OF THE SEPTUM NARIUM.
Authors: W. E. CASSELBERRY
Journal: JAMA (1897)

The condition which, for the sake of simplicity in nomenclature is designated "Abscess of the Septum," only occasionally presents the typical characteristics of acute circumscribed suppuration. When caused by traumatism the first stage may be an effusion of blood beneath the muco-perichondrium of the cartilaginous septum which is termed "Hematoma of the Septum." In time the blood degenerates, perhaps becomes infected by pyogenic microorganisms and changes to a brownish yellow fluid which when evacuated appears neither like blood nor typical pus. In this state it has been called "Cold Abscess," and again when it does originate without traumatism and runs an acute course with pain, fever and obstructive swelling terminating in ideal suppuration, it has been spoken of as "Acute Perichondritis." Jurasz<sup>1</sup>has described a form in which the contained fluid is at first serous, termed serous perichondritis. Some sort of abscess is the culminating stage of all these
Lymphoma cell adhesion-induced expression of B cell-activating factor of the TNF family in bone marrow stromal cells protects non-Hodgkin's B lymphoma cells from apoptosis
Authors: T Lwin, L A Crespo, A Wu, S Dessureault, H B Shu, L C Moscinski, E Sotomayor, W S Dalton, J Tao
Journal: Leukemia (2008)
CAUTION IN USING CALCIUM INTRAVENOUSLY
Authors: Jacob Alperin
Journal: JAMA (1960)

<h3>To the Editor:—</h3> In your editorial of July 2, 1960, page 1032, "Use of Air Pressure to Speed up Blood Transfusion," mention is made of the intravenous administration of calcium. I would like to offer a note of caution, since calcium given intravenously would be dangerous to a patient who has been digitalized. In many instances such patients are very ill, and, if they have been receiving digitalis, calcium should not be used. It is well known that calcium given intravenously depresses the cardiac pacemaker and increases the excitability of ventricular muscle. Some deaths have been reported when calcium was administered intravenously to patients who had been receiving digitalis.
Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance.
Authors: L C Groop, R C Bonadonna, S DelPrato, K Ratheiser, K Zyck, E Ferrannini, R A DeFronzo
Journal: Journal of Clinical Investigation (1989)

The effect of graded, physiologic hyperinsulinemia (+5, +15, +30, +70, +200 microU/ml) on oxidative and nonoxidative pathways of glucose and FFA metabolism was examined in nine lean non-insulin dependent diabetic patients (NIDDM) and in eight age- and weight-matched control subjects. Glucose and FFA metabolism were assessed using stepwise insulin clamp in combination with indirect calorimetry and infusion of [3H]3-glucose/[14C]palmitate. The basal rate of hepatic glucose production (HGP) was higher in NIDDM than in control subjects, and suppression of HGP by insulin was impaired at all but the highest insulin concentration. Glucose disposal was reduced in the NIDD patients at the three highest plasma insulin concentrations, and this was accounted for by defects in both glucose oxidation and nonoxidative glucose metabolism. In NIDDs, suppression of plasma FFA by insulin was impaired at all five insulin steps. This was associated with impaired suppression by insulin of plasma FFA turnover, FFA oxidation (measured by [14C]palmitate) and nonoxidative FFA disposal (an estimate of reesterification of FFA). FFA oxidation and net lipid oxidation (measured by indirect calorimetry) correlated positively with the rate of HGP in the basal state and during the insulin clamp. In conclusion, our findings demonstrate that insulin resistance is a general characteristic of glucose and FFA metabolism in NIDDM, and involves both oxidative and nonoxidative pathways. The data also demonstrate that FFA/lipid and glucose metabolism are interrelated in NIDDM, and suggest that an increased rate of FFA/lipid oxidation may contribute to the impaired suppression of HGP and diminished stimulation of glucose oxidation by insulin in these patients.