HMG-CoA Reductase Inhibitor Therapy and Peripheral Neuropathy
Authors: Michael B. Jacobs
Journal: Annals of Internal Medicine (1994)

Letters1 June 1994HMG-CoA Reductase Inhibitor Therapy and Peripheral NeuropathyMichael B. Jacobs, MDMichael B. Jacobs, MDStanford University Clinic; Palo Alto, CA 94304-2205Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-11-199406010-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Lovastatin and pravastatin are inhibitors of the rate-limiting agent in cholesterol synthesis, 3-hydroxy-3 methyl-glutaryl-coenzyme A (HMG-CoA) reductase. Effective in lowering both low-density lipoprotein and total cholesterol levels, they are generally well tolerated. Documented adverse effects include gastrointestinal disturbances, rash, headaches, myalgias, myopathy, and increases in aminotransferase values [1, 2].I report a case of reversible sensory neuropathy associated with lovastatin and pravastatin therapy. A 47-year-old woman was seen for a routine check-up in May 1991. Except for mild obesity, her complete examination was normal, including intact ankle reflexes and vibratory sensation. Laboratory findings showed normal values for ...References1. Choice of cholesterol lowering drugs. Med Lett Drugs Ther. 1993; 35:19-22. Google Scholar2. Lovastatin: 5 year safety and efficacy study. Lovastatin Study Groups I through IV. Arch Intern Med. 1993; 153:1079-87. Google Scholar Author, Article, and Disclosure InformationAffiliations: Stanford University Clinic; Palo Alto, CA 94304-2205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAtorvastatin-Induced Polyneuropathy Michael B. Jacobs Metrics Cited ByThe association between statins exposure and peripheral neuropathy risk: A meta‐analysisNeurological complications of cardiovascular drugsRelationship between Bell's Palsy and Previous Statin Use: A Case/Non-Case StudyStatin use and peripheral nerve function—A prospective follow‐up studyStatins and polyneuropathy revisited: case-control study in Denmark, 1999-2013Statins: Do They Aggravate or Ameliorate Neuropathic Pain?Drug-Induced Toxic NeuropathiesAssociation of statin use with peripheral neuropathy in the US population 40 years of age or older (美国40岁及以上人群的他汀使用情况与周围神经病变的关系)QSART for diagnosis of statin-associated polyneuropathyStatins and peripheral neuropathy: causation or coincidence?Atorvastatin-induced Guillain-Barre Syndrome - A Case Report -Update on medication-induced peripheral neuropathyNeurotoxic Effects of Pharmaceutical Agents V: Miscellaneous AgentsStatin Adverse EffectsTREATMENT WITH STATINS AND INVOLVEMENT OF THE PERIPHERAL NERVOUS SYSTEM: RESULTS OF A PROSPECTIVE CLINICAL AND NEUROPHYSIOLOGICAL FOLLOW-UPDixièmes Journées des Maladies du Système Nerveux Périphérique Neuropathies aux statines, mythe ou réalité?Statin Safety: An Overview and Assessment of the Data—2005Advances in Understanding Drug-Induced NeuropathiesStatins and polyneuropathy: Setting the record straightToxic neuropathyAdverse effects of statinsDo Statins Increase the Risk of Idiopathic Polyneuropathy?Disorder resembling Guillain-Barré syndrome on initiation of statin therapyStatin-Associated Peripheral Neuropathy: Review of the LiteratureAtorvastatin-Induced PolyneuropathyMichael B. Jacobs, MDSimvastatin-induced mononeuropathy multiplex: case reportAssociation of HMG-CoA Reductase Inhibitors with NeuropathyMedication-induced peripheral neuropathyHMG-CoA Reductase Inhibitors and MyotoxicityEncephalomyeloradiculoneuropathy following exposure to an industrial solventHMG-CoA Reductase Inhibitor-Induced ImpotenceLovastatin/pravastatinPeriphere Neuropathie 1 June 1994Volume 120, Issue 11Page: 970KeywordsAnklesCholesterolLow density lipoproteinPeripheral neuropathyRashesReflexesResearch laboratoriesSafety studiesSensory neuropathyTendons Issue Published: 1 June 1994 CopyrightCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...