Ranitidine and Bradycardia
Authors: WALTER S. JOHNSON
Journal: Annals of Internal Medicine (1988)

Letters and Corrections1 March 1988Ranitidine and BradycardiaWALTER S. JOHNSON, M.D., DONALD R. MILLER, PHARM.D.WALTER S. JOHNSON, M.D.Search for more papers by this author, DONALD R. MILLER, PHARM.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-3-493 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The histamine-2 (H2) receptor antagonist drugs (Cimetidine, ranitidine, and famotidine) are generally well tolerated. However, several less common but serious side effects have been reported, including mental confusion, gynecomastia, neutropenia, hepatitis, and cardiac arrhythmias. We report the case of a patient who had two episodes of bradycardia possibly related to ranitidine treatment.A hypertensive, diabetic 73-year-old man with mild renal insufficiency was transferred to our hospital 2 days after emergency surgery for a colonic perforation and subsequent Klebsiella peritonitis, renal failure, and confusion. At admission he was hypovolemic, and intravenous fluid replacement and dopamine were started.Laboratory...References1. PAPP J and RESCH B. Histaminergic mechanisms in the developing human heart. Agents Actions. 1975;5:463. CrossrefMedlineGoogle Scholar2. CAMARRI E, CHIRONE E, FANTERIN G, and ZOCCHI M. Ranitidine induced bradycardia. Lancet. 1982;2:1108. Google Scholar3. SHAH R. Symptomatic bradycardia in association with H2-receptor antagonists. Lancet. 1982;2:1108. CrossrefMedlineGoogle Scholar4. MATTHEWS S, MICHELSON P, and CERSOSIMO R. Cimetidine-induced bradycardia. Clin Pharm. 1982;1:556-8. MedlineGoogle Scholar5. GARY D, BALTODANO N, and JALLAD N. Pharmacokinetics of ranitidine in patients with renal failure. J Clin Pharmacol. 1986;26:286-91. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WALTER S. JOHNSON, M.D.; DONALD R. MILLER, PHARM.D.Affiliations: Dakota Clinic, Limited Fargo, ND 58108 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBradycardia Associated with Intravenous Methadone Administered for Sedation in a Patient with Acute Respiratory Distress SyndromeCisapride-induced long QT interval: What is therole of ranitidine?Ranitidine-lnduced Bradycardia in a Patient With DextrocardiaRanitidine-Induced Bradycardia in a Patient With DextrocardiaClinical Aspects of Cardiovascular Effects of H 2 -Receptor AntagonistsRRanitidine-induced bradycardia in a neonate — a first reportPharmacological control of gastric acid secretion: Molecular and cellular aspectsCase Report of a Syncopal Episode Associated with FluoxetineHaemodynamic effects of H 2 -receptor antagonistsCardiovascular Effects of Omeprazole and FamotidineReplyBradycardia and H2 AntagonistsL. Ann Tanner, RPh, Janet B. Arrowsmith, MD 1 March 1988Volume 108, Issue 3Page: 493-493KeywordsBradycardiaDrugsFamotidineHepatitisKlebsiellaNeutropeniaPeritonitisRenal failureResearch laboratoriesSurgery ePublished: 1 December 2008 Issue Published: 1 March 1988 PDF downloadLoading ...