tbuckley/cabot-search huggingface dataset:
Abstract 3929: ADA3, a component of ATAC complex regulates DNA damage response
Authors: Sameer Mirza, Shakur Mohibi, Channabasavaiah B. Gurumurthy, Bryan J J. Katafiasz, Xiangshan Zhao, Aditya Bele, Hamid Band, Vimla Band
Journal: Cancer Research (2011)

Abstract Our long term research goal is to understand the biochemical mechanism of immortalization of human epithelial cells that represents early step in cancer progression. Over the years, we have generated several epithelial cell immortalization models, using viral oncogenes, mutated cancer genes, as well as radiation treatment of cells. In one of such immortalization model, we identified alteration/deficiency in activation (ADA3) protein as a novel human papilloma virus E6 oncoprotein binding protein, and as a regulator of p53 function. We and others have shown that human ADA3 protein is an essential component of various Histone acetyl transferase complexes (HATs) and thus controls transactivation of various transcriptional factors. To gain insight into the physiological importance of ADA3, we established a conditional knockout mouse model and showed that loss of ADA3 led to embryonic lethality at an early stage of development. Using ADA3lox/lox mouse embryonic fibroblast (MEF) cell lines, we further showed that ADA3 plays an important role in DNA damage and repair pathway. Adenovirus cre-mediated deletion of ADA3 led to a global reduction of histone acetylation, severe G2/M cell cycle arrest, various aberration in nuclear structures, and massive chromosome aberration. Significantly, cells lacking ADA3 showed defects in recruitment of DNA repair associated proteins, BRCA1 and 53BP1 to the DNA damage foci. These results implicate ADA3 as a major cell cycle and DNA repair response regulating protein. These findings in the context of oncogenesis and chemotherapy will be discussed. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3929. doi:10.1158/1538-7445.AM2011-3929
Nerve-Sparing Radical Retropubic Prostatectomy in Patients Previously Submitted to Holmium Laser Enucleation of the Prostate for Bladder Outlet Obstruction Due to Benign Prostatic Enlargement
Authors: Nazareno Suardi, Vincenzo Scattoni, Alberto Briganti, Andrea Salonia, Richard Naspro, Andrea Gallina, Andrea Cestari, Renzo Colombo, Pierre I. Karakiewicz, Giorgio Guazzoni, Patrizio Rigatti, Francesco Montorsi
Journal: European Urology (2007)
An Address on the Treatment of Some Common Female Ailments
Authors: F. J. McCann
Journal: BMJ (1918)

IT must be witlh feelings akin to despair that tlle practi- tioner turns for guidance to the modern textbooks on the diseases of womnen.Thje plendulum has swung so far in the opposite direction that one arises from the perusal of the recent textbooks tlhinking tljat surgical treatmtient is tlle one and only remedy for suffering womjlen.Yet it is by tle judicious comnbination of medical and surgical treatmlent that the practitioner becomes a safe guide to his patient in her struggle against disease.All commlMonl ailmnents are imn,portant because tlhey are common, and for this reason, if for lno otlher, require special consideration.My puLrpose, tlhen, is to direct attention to tlhose r'emiledial agents whlichl I have found useful in the treatmiient of wlhat may be termed " commnon female ailments."MENSTRUAL DISORDERS.Amongst common female ailments mnenstrtual disorders are frequently encountered.Thje recent workh on the duct-
Nitration of Proteins in Bronchoalveolar Lavage Fluid from Patients with Acute Respiratory Distress Syndrome Receiving Inhaled Nitric Oxide
Authors: NICHOLAS J. LAMB, GREGORY J. QUINLAN, SARAH T. WESTERMAN, JOHN M. C. GUTTERIDGE, TIMOTHY W. EVANS
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Inhaled nitric oxide ( · NO) is used to improve gas exchange and reduce pulmonary vascular resistance (PVR) in patients with the acute respiratory distress syndrome (ARDS). Although controlled studies have shown no survival benefit, some investigators have suggested that inhaled · NO may have antiinflammatory properties under these circumstances. In contrast, others have speculated that · NO given by inhalation could be cytotoxic, as it combines with superoxide at near diffusion-limited rates to produce the highly reactive oxidant peroxynitrite (ONOO−). We therefore quantified levels of 3-nitrotyrosine, a marker for ONOO− formation, in bronchoalveolar lavage fluid (BAL) from patients with ARDS receiving inhaled · NO, and from patients with comparable lung injury who were not so treated. We also measured levels of 3-chlorotyrosine as an index of neutrophil activation to assess indirectly the effects of inhaled · NO on lung inflammation. Patients receiving · NO had increased levels of 3-nitrotyrosine (6.76 ± 2.79 versus 0.4 ± 0.15 nmol/mg of protein, p < 0.05) and 3-chlorotyrosine (7.97 ± 2.74 versus 1.53 ± 1.09 nmol / mg of protein, p < 0.05) in BAL protein compared with controls. In patients with ARDS, inhaled · NO increases the formation of 3-nitrotyrosine and is accompanied by an increase in levels of 3-chlorotyrosine (a marker of neutrophil activation). The possible long-term consequences of these observations remain to be evaluated.
The Difficult Issue of Second-Trimester Abortion
Authors: Allan Rosenfield
Journal: New England Journal of Medicine (1994)

Over the past several decades, no issue has engendered more controversy, hostility, and even violence than abortion1,2. And there is probably no single issue for which a resolution is less likely. For those who believe that life begins at fertilization or implantation, abortion at any stage of pregnancy constitutes murder, and for this group there is no likelihood that there will be any acceptable compromise. Similarly, for those who believe that women must be able to make the final decisions about their bodies where reproduction is concerned, there is also no compromise. The views of the majority of . . .
Evaluation of single-dose hypnotic treatment before elective operation.
Authors: M R Keighley, M Gannon, J Warlow, C R Jenkins, R J Gammon
Journal: BMJ (1980)

A prospective randomised double-blind controlled trial was carried out to evaluate the place of a single dose of triazolam, flurazepam, and placebo on the evening before an elective operation in 96 patients. Features of sleep were recorded by patients and nurses on questionnaires. Onset of sleep was delayed and duration of sleep reduced in two-thirds of patients allocated placebo compared with their normal sleep pattern. Two-thirds of these patients also complained of waking more than twice during the night. Both hypnotics significantly improved the duration and time of onset of sleep and reduced the frequency of wakening when compared with the placebo. Patients who took triazolam, however, fell asleep faster and woke less often than those who took flurazepam. Furthermore, triazolam appeared to have advantages over flurazepam before surgery. Thus giving a single dose of a hypnotic on the night before an elective operation improves the patient9s sleep, and greater benefit was derived from triazolam than flurazepam.
Absorption of Free Acid, Potassium, and Benzathine Phenoxymethylpenicillin after Oral Administration
Authors: J. Colquhoun, E. C. Scorer, G. Sandler, G. M. Wilson
Journal: BMJ (1957)

<h3>Objectives</h3> To determine the impact on clinicians and any consequent influence on patient care of taking part in the bespoke interface-focused educational intervention. <h3>Design</h3> Qualitative design. <h3>Setting</h3> Primary and secondary care centres in NHS Highland health board area, Scotland. <h3>Participants</h3> 33 urban-based clinicians (18 general practitioners and 15 hospital specialists) in NHS Highland, Scotland. <h3>Intervention</h3> An interface-focused educational intervention was carried out in primary and secondary care centres in NHS Highland health board area, Scotland. Eligible clinicians were invited to take part in the intervention which involved facilitated small group work, and use of a bespoke educational module. Subsequent one-to-one interviews explored the impact of the intervention. A standard thematic analysis was used, comprising an iterative process based on grounded theory. <h3>Results</h3> Key themes that emerged included fresh insights (in relation to those individuals and processes across the interface), adoption of new behaviours (eg, being more empowered to directly contact a colleague, taking steps to reduce the others workload and changes in professional approach) and changes in terms of communication (including a desire to communicate more effectively, with use of different modes and methods). <h3>Conclusion</h3> The study highlighted key areas that may serve as useful outcomes for a large-scale randomised trial. Addressing issues identified in the study may help to improve interface relationships and benefit patient care.
Effects of changes in the aortic input impedance on systolic pressure-ejected volume relationships in the isolated supported canine left ventricle
Authors: N. ISHIDE, Y. SHIMIZU, Y. MARUYAMA, Y. KOIWA, T. NUNOKAWA, S. ISOYAMA, S. KITAOKA, K. TAMAKI, E. INO-OKA, T. TAKISHIMA
Journal: Cardiovascular Research (1980)

We examined the effects of aortic input impedance alteration on left ventricular pressure, aortic flow and ejected volume (integral value of aortic flow), in an isolated blood perfused ejecting canine heart, with special reference to end-systolic values. A hydraulic model which stimulates an aortic input impedance was attached to the aortic root of an excised heart. Left ventricular end-diastolic pressure was kept constant by electrical pacing. Three coronary arteries were perfused with arterial blood from support dogs. When the peripheral resistance in the hydraulic model was changed, there were inverse linear relationships between stroke volume and mean left ventricular systolic pressure and between ejected volume and pressure at end-systole. Time interval from the onset of contraction to end-systole did not change. Thus the relation between stroke volume and mean left ventricular pressure obtained by changes in peripheral resistance is governed by a source resistance, which can be considered as the contractile state of the ventricle. When the capacitance (arterial compliance) was changed, there was no inverse linear relation between stroke volume and mean systolic pressure. In many cases, there was an inverse linear relationship between ejected volume and pressure at end-systole. However, an increase in capacitance prolonged the time interval from the onset of contraction to end-systole. We conclude that the end-systolic pressure-ejected volume relationship in the ejecting heart is governed not only by contractility but also by arterial capacitance.
Blood levels of cyclosporin
Authors: W. Cunliffe
Journal: British Journal of Dermatology (1988)

Journal Article Blood levels of cyclosporin Get access W. Cunliffe W. Cunliffe Dermatology Department, Leeds General Infirmary, Leeds LS1 3EX U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 119, Issue 2, 1 August 1988, Page 272, https://doi.org/10.1111/j.1365-2133.1988.tb03216.x Published: 01 August 1988
Unusual Abdominal Involvement in Rickettsial Diseases
Authors: S. Mansueto
Journal: JAMA (1983)

To the Editor.—  Abdominal involvement is unusual not only in Rocky Mountain Spotted Fever (RMSF), as pointed out by Davis and Bradford inThe Journal(1982;247:2811), but also in another milder rickettsiosis, which, surprisingly, has an increased incidence in our country. Boutonneuse fever (BF), caused by Rickettsia conorii , is related to RMSF for several reasons, including a history of tick contact and/or eschar, summer incidence, fever, or characteristic rash.  Report of Cases.—Case 1.—  We have observed 1 a case of pancreatic involvement in a 41-year-old man seen in an emergency room for abdominal pain and fever. During the next 24 hours, a characteristic maculopapular rash appeared. In addition, other data provided evidence for the diagnosis as follows: (1) positive serologic test findings (ELISA, positive for specific R conorii antigen and a positive Weil-Felix reaction for Proteus 0X2 antigen), (2) progressive increase of amylasemia (up to 1,000 units/L; reference
Relation between bed use, social deprivation, and overall bed availability in acute adult psychiatric units, and alternative residential options: a cross sectional survey, one day census data, and staff interviews
Authors: G Shepherd, A Beadsmoore, C Moore, P Hardy, M Muijen
Journal: BMJ (1997)

<h3>Abstract</h3> <b>Objectives:</b> To examine the relation between bed use, social deprivation, and overall bed availability in acute adult psychiatric units and to explore the range of alternative residential options. <b>Design:</b> Cross sectional survey, combined with one day census data; ratings by and interviews with staff; examination of routine data sources. <b>Settings:</b> Nationally representative sample of acute psychiatric units. <b>Subjects:</b> 2236 patients who were inpatients on census day. <b>Main outcome measures:</b> Bed occupancy levels, judged need for continuing inpatient care, reasons preventing discharge, scores on the Health of the Nation outcome scales. <b>Results:</b> Bed occupancy was related to social deprivation and total availability of acute beds (<i>r</i> =0.66, 95% confidence interval 0.19 to 0.88, F=8.72, df=2, 23; P=0.002). However, 27% (603/2215) of current inpatients (61% (90/148) of those with stays of &gt;6 months) were judged not to need continuing admission. The major reasons preventing discharge were lack of suitable accommodation (37% (176/482) of patients in hospital &lt;6 months <i>v</i> 36% (31/86) of those in hospital &gt;6 months); inadequate domiciliary based community support (23% (113) <i>v</i> 9% (8)); and lack of long term rehabilitation places (21% (100) <i>v</i> 47% (40)). Scores on the Health of the Nation outcome scale were generally consistent with these staff judgments. <b>Conclusions:</b> The shortage of beds in acute psychiatric units is related to both social deprivation and the overall availability of acute beds. Patients currently inappropriately placed on acute admission wards should be relocated into more suitable accommodation, either in hospital or in the community. A range of provisions is required; simply providing more acute beds is not the answer. <h3>Key messages</h3> This study shows that there is a shortage of acute psychiatric beds and that this is related to both social deprivation and the overall availability of beds Over a quarter of inpatients were considered to be inappropriately placed on admission wards–for those with lengths of stay of more than six months this figure increased to 61% Lack of suitable accommodation, home based support, and rehabilitation places was identified as the major reason preventing discharge A range of hospital and community facilities is therefore required to address these problems of over-occupancy and shortages of acute beds
Absence of chromosome damage in human lymphocytes exposed to allopurinol and oxipurinol.
Authors: A.C Stevenson, S.R Silcock, J.T Scott
Journal: Annals of the Rheumatic Diseases (1976)

The biochemical evidence against incorporation of the purine analogues, allopurinol and oxipurinol, into nucleic acids is reviewed. Cytological experiments have been carried out to investigate the possibility that chromosomal damage might result from exposure of human lymphocytes to these drugs. Lymphocytes from 19 patients receiving allopurinol and one receiving oxipurinol were examined for the presence of chromatid aberrations during metaphase, and lymphocytes from untreated subjects were similarly studied during in vitro exposure to the drugs. The low frequency of aberrations observed was well within normal limits, and it is concluded that allopurinol and oxipurinol have no deleterious effects on chromosome structure.
Deletion of the p110β isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo
Authors: Valérie Martin, Julie Guillermet-Guibert, Gaétan Chicanne, Cendrine Cabou, Martine Jandrot-Perrus, Monique Plantavid, Bart Vanhaesebroeck, Bernard Payrastre, Marie-Pierre Gratacap
Journal: Blood (2010)
Abstract 5421: Stage specific inhibitory effect and associated mechanisms of insositol hexaphosphate on tumor progression and angiogenesis in TRAMP model
Authors: Komal Raina, Kameswaran Ravichandran, Anil Jain, Mallikarjuna Gu, Yogesh Sharma, Ritambhara Wadhwa, Rajesh Agarwal
Journal: Cancer Research (2012)

Abstract Prostate cancer (PCa) is the leading cause of cancer-related deaths in elderly men in US; ACS’ statistical estimates for 2011 report ∼240,890 new PCa cases and 33,720 associated deaths. In recent years, transgenic adenocarcinoma of the mouse prostate (TRAMP) has been the most frequently employed PCa model to evaluate chemopreventive efficacy of various agents. This model closely mimics human form of the disease, wherein prostate carcinogenesis progresses in a step-wise manner with the age of the mouse. The well defined stages of prostate tumor growth, progression and angiogenesis in TRAMP model provide unique opportunity to assess ‘stage specific’ preventive efficacy of an agent. Accordingly, employing TRAMP model, here we assessed stage-specific efficacy of inositol hexaphosphate (IP6) feeding on PCa initiation and growth, progression and angiogenesis, and elucidated the molecular events involved in IP6 effects during these stages. Different groups of male TRAMP mice starting at 4, 12, 20 and 30 weeks of age were fed with regular drinking water or 2% IP6 in regular drinking water for 8-10 weeks. At the end of the study, histopathological analysis of prostate showed that all the mice fed with IP6 at different time-points display less severe prostatic lesions compared to non-IP6 fed positive control mice. During early stages of prostate tumor development, IP6 mediated its chemopreventive effect mostly via anti-proliferative and pro-apoptotic mechanisms. Feeding of IP6 to animals burdened with higher stages of prostate tumor significantly decreased tumor grade via anti-proliferative effect and inhibition of angiogenesis as evidenced by decreased expression of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD-31), vascular endothelial growth factor (VEGF) hypoxia-inducible factor-1a (HIF-1a) and inducible nitric oxide synthase (iNOS). These effects of IP6 also correlated with an alteration of epithelial-mesenchymal transition (EMT) as was evidenced by a decreased expression of mesenchymal markers Snail-1 in the prostatic tissue and retention of epithelial characteristics determined by localization of E-cadherin. Together, the findings in the present study are both novel and highly significant in establishing the dual efficacy of IP6, where it inhibits initiation and progression of primary prostatic tumor and also exerts protective efficacy against angiogenesis. These effects of IP6 should have potential implications to control PCa growth and improve the morbidity and survival time in PCa patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5421. doi:1538-7445.AM2012-5421
Assessment and prognostic value of the European LeukemiaNet criteria for clinicohematologic response, resistance, and intolerance to hydroxyurea in polycythemia vera
Authors: Alberto Alvarez-Larrán, Arturo Pereira, Francisco Cervantes, Eduardo Arellano-Rodrigo, Juan-Carlos Hernández-Boluda, Francisca Ferrer-Marín, Anna Angona, Montse Gómez, Begoña Muiña, Helga Guillén, Anabel Teruel, Beatriz Bellosillo, Carmen Burgaleta, Vicente Vicente, Carles Besses
Journal: Blood (2011)
Propranolol and Threatened Myocardial Infarction
Authors: Burton E. Sobel
Journal: New England Journal of Medicine (1979)

Norris and his colleagues recently described protective effects of propranolol among patients with threatened myocardial infarction.1 Their report highlights the remarkably rapid evolution of recent thinking concerning protection of ischemic myocardium with beta-adrenergic blockade.Initial efforts to protect ischemic myocardium were stimulated by the hypotheses that prognosis after acute myocardial infarction depended in part on infarct size and that infarct size could be modified favorably by a reduction in oxygen requirements or augmentation of oxygen supply to jeopardized ischemic tissue.2 Results in laboratory animals and patients demonstrated protection under defined conditions as well as a relation between the extent of . . .
Pitfalls in the diagnosis of phaeochromocytoma
Authors: L Zendron, J Fehrenbach, C Taverna, M Krause
Journal: BMJ (2004)

Phaeochromocytoma, a rare endocrine disorder causing arterial hypertension, is found in less than 0.1% of patients with hypertension.1 The diagnosis is excluded by the repeated finding of normal catecholamine (for example, dopamine) concentrations in urine or blood. If catecholamine concentrations are increased in combination with an adrenal mass, phaeochromocytoma is usually confirmed by an increased uptake of a radiolabelled catecholamine precursor in the region of the adrenal tumour. We present a case in which the clinical presentation and the results of laboratory, radiological, and nuclear investigations led to an incorrect diagnosis of phaeochromocytoma.

A 73 year old woman presented with severe headache, tinnitus, and a blood pressure of 240/140 mm Hg. She had been treated for arterial hypertension and diabetes mellitus for over 10 years. During a search for secondary hypertension, abdominal ultrasonography showed an enlargement of the right adrenal gland of 3.5 cm. The dopamine level in a 24 hour urine was 25 252 nmol …
Suppression of secondary hyperparathyroidism in uraemia: acute and chronic studies.
Authors: N Muirhead, G R Catto, N Edward, S Adami, R M Manning, J L O'Riordan
Journal: BMJ (1984)

A study was conducted evaluating the response of serum parathyroid hormone to acute hypercalcaemia and long term administration of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in patients receiving maintenance haemodialysis. During infusion of elemental calcium 4 mg/kg/h over four hours in 12 patients not receiving vitamin D the concentration of serum amino terminal parathyroid hormone fell by 31-96% (mean 74.8 (SD 17.6)%) while that of carboxy terminal parathyroid hormone changed little. There was a strong inverse correlation between baseline serum calcium concentration and percentage fall in amino terminal parathyroid hormone during infusion (r = 0.88; p less than 0.001). In seven patients who received prolonged treatment with 1,25(OH)2D3 after calcium infusion there was a positive correlation between maximum percentage fall in amino terminal parathyroid hormone during infusion and the percentage fall in amino terminal parathyroid hormone after 1,25(OH)2D3 treatment (r = 0.79; p less than 0.05). The responsiveness of the parathyroid glands to changes in calcium in acute studies may be used to predict the efficacy of long term treatment with 1,25(OH)2D3. Patients in whom calcium infusion does not suppress parathyroid hormone may have true parathyroid autonomy and require early parathyroidectomy.