Fixed and Reproducible Orthostatic Proteinuria
Authors: FRANK R. LECOCQ
Journal: Annals of Internal Medicine (1966)

Article1 March 1966Fixed and Reproducible Orthostatic ProteinuriaV. Results of a 5-Year Follow-up EvaluationFRANK R. LECOCQ, JOHN J. MCPHAUL, ROSCOE R. ROBINSON, M.D., F.A.C.P.FRANK R. LECOCQSearch for more papers by this author, JOHN J. MCPHAULSearch for more papers by this author, ROSCOE R. ROBINSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-3-557 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough orthostatic proteinuria has been traditionally regarded as a benign and transient condition of adolescence (1-6), recent observations have indicated that this long-standing clinical opinion may be incorrect (7-11). In particular, it has been suggested that the "fixed and reproducible" form of orthostatic proteinuria may reflect an early manifestation of underlying renal disease (7-10). This concept has largely arisen from the demonstration that this type of proteinuria is more apt to persist than disappear (7), that obvious signs of renal disease may appear in some patients within a few years (7), and that an underlying structural alteration of glomerular architecture...References1. FISHBERG AM: Hypertension and Nephritis, 5th ed. Lea & Febiger, Philadelphia, 1954, pp. 396-407. Google Scholar2. PARKIN TW: Postural proteinuria. Med. Clin. N. Amer. 35: 1017, 1951. CrossrefGoogle Scholar3. WATSON A: Orthostatic albuminuria; time-saving method of diagnosis. Lancet 1: 1196, 1951. CrossrefMedlineGoogle Scholar4. BULL GM: Postural proteinuria. Clin. Sci. 7: 77, 1948. MedlineGoogle Scholar5. PRINCE CL: Orthostatic albuminuria. J. Urol. 50: 608, 1943. CrossrefGoogle Scholar6. BASHFORD HH: Albuminuria in adolescence. Practitioner 135: 272, 1935. Google Scholar7. KING SE: Albuminuria (proteinuria) in renal diseases. II. Preliminary observations on the clinical course of patients with orthostatic albuminuria. New York J. Med. 59: 825, 1959. MedlineGoogle Scholar8. KING SE: Diastolic hypertension and chronic proteinuria. Amer. J. Cardiol. 9: 669, 1962. CrossrefMedlineGoogle Scholar9. ROBINSONGLOVERPHILLIPPILECOCQLANGELIER RRSNPJFRPR: Fixed and reproducible orthostatic proteinuria. I. Light microscopic studies of the kidney. Amer. J. Path. 39: 291, 1961. MedlineGoogle Scholar10. ROBINSONASHWORTHGLOVERPHILLIPPILECOCQLANGELIER RRCTSNPJFRPR: Fixed and reproducible orthostatic proteinuria. II. Electron microscopy of renal biopsy specimens from 5 cases. Ibid., p. 405. Google Scholar11. ROBINSONLECOCQPHILLIPPIGLENN RRFRPJWG: Fixed and reproducible orthostatic proteinuria. III. Effect of induced renal hemodynamic alterations upon urinary protein excretion. J. Clin. Invest. 42: 100, 1963. CrossrefMedlineGoogle Scholar12. ROBINSONGLENN RRWG: Fixed and reproducible orthostatic proteinuria. IV. Urinary albumin excretion by healthy human subjects in the recumbent and upright postures. J. Lab. Clin. Med. 64: 717, 1964. MedlineGoogle Scholar13. KING SE: Patterns of protein excretion by the kidneys. Ann. Intern. Med. 42: 296, 1955. LinkGoogle Scholar14. DEROW HA: The diagnostic value of serial measurements of albuminuria in ambulatory patients. New Eng. J. Med. 227: 827, 1942. CrossrefGoogle Scholar15. HARE RS: Endogenous creatinine in serum and urine. Proc. Soc. Exp. Biol. Med. 74: 148, 1950. CrossrefMedlineGoogle Scholar16. FOSTERRICKWOLFSON PJW: Extension of the standard biuret method to the estimation of total protein in urine. J. Lab. Clin. Med. 39: 618, 1952. MedlineGoogle Scholar17. SEARCYGOUGHKOROTZERBERGQUIST RLGSJGLM: Evaluation of a new technique for direct estimation of urea nitrogen in serum. Amer. J. Med. Techn. 27: 255, 1961. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Lackland Air Force Base, Texas, and Durham, North CarolinaFrom the Departments of Medicine, Wilford Hall USAF Hospital, Lackland Air Force Base, Tex., and the Duke University Medical Center, Durham, N. C.This study was supported by Air Force contract 41(609)-2283.Requests for reprints should be addressed to Roscoe R. Robinson, M.D., Box 3014, Duke University Medical CenterDurham, N. C. 27706. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByUrinary Parameters to Assess Renal FunctionThe prognostic significance of proteinuria: The Framingham studyProteinuria: Diagnostic Principles and ProceduresJ. GARY ABUELO, M.D.Fixed and Reproducible Orthostatic Proteinuria: Results of a 20-Year Follow-up StudyPETER D. SPRINGBERG, LELAND E. GARRETT Jr., ALFRED L. THOMPSON Jr., M.D., NANCY F. COLLINS, B.A., ROBERT E. LORDON, ROSCOE R. 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LEVITT, M.D.The interpretation of proteinuria and the urinary sediment 1 March 1966Volume 64, Issue 3Page: 557-569KeywordsAdolescentsHospital medicineHypertensionProteinuriaRenal diseases Issue Published: 1 March 1966 PDF DownloadLoading ...