tbuckley/cabot-search huggingface dataset:
Diagnosis of ventricular septal defect by pulsed Doppler echocardiography. Sensitivity, specificity and limitations.
Authors: J G Stevenson, I Kawabori, T Dooley, W G Guntheroth
Journal: Circulation (1978)

The M-mode echocardiographic findings of ventricular septal defect (VSD) are nonspecific. A specific pulsed Doppler echocardiographic (PDE) diagnosis of VSD can be made by following the turbulent VSD jet through the septum. To assess the sensitivity, specificity and limitations of PDE diagnosis of VSD, 105 children undergoing cardiac catheterization were examined by PDE. These children had a variety of cardiac defects, and a PDE diagnosis of VSD was made in 46/51 (90%) who had VSD proven at catheterization. There was one false positive PDE diagnosis of VSD, for a specificity of 98%. Factors influencing the ability to diagnose VSD by PDE include the location of the defect, level of pulmonary vascular resistance and direction of blood flow through the VSD. The presence of additional defects did not interfere with PDE diagnosis of VSD. The PDE detection of additional defects may identify situations where M-mode echocardiographic estimation of dimensions may not be indicative of the size of VSD shunt.
Hazards of central venous catheterization.
Authors: M J McMahon
Journal: BMJ (1973)

The abnormal lipid pattern is the first change to occur as hypothyroidism de- velops and the last to disappear on treat- ment, or remains the sole abnormal finding on inadequate therapy as shown in the data presented by Dr. Evered and his col- leagues.Although the lipid alteration is unexplained, it cannot therefore be dis- missed with the words, "the hepatic mechanisms for cholesterol excreion and catabolism are unlikely to be prescient of a future hormone deficiency."3The conclusions regarding T4 dosage, reached as a result of the excellent work by Dr. Evered and his colleagues, are in conflict with mine, based on simpler tests done on a great number of patients.Dr.Evered and his colleagues will warn that over-treated hypothyroid patients will suffer from fragile bones and I will con- tinue to warn that under-treated hypothyroid patients may die of coronary artery disease.-Iam, etc.,
Simvastatin‐Loaded β‐TCP Drug Delivery System Induces Bone Formation and Prevents Rhabdomyolysis in OVX Mice
Authors: Joshua Chou, Tomoko Ito, Makoto Otsuka, Besim Ben‐Nissan, Bruce Milthorpe
Journal: Advanced Healthcare Materials (2012)

Bone formation and regeneration is a prolonged process that requires a slow drug release system to assist in the long-term recovery. A drug-delivery system is developed that allows for the controlled release of simvastin, without exhibiting the side effects associated with high concentrations of simvastatin, and is still capable of inducing constant bone formation.
ADDISON'S DISEASE; TWO CASES IN ONE FAMILY.
Authors: L. W. SCHWAB
Journal: JAMA (1898)

My object in reporting this case is its rarity, difficulty of early recognition and the fact that two brothers died from this disease within thirteen months of each other. I will first give the younger brother's case. Mr. C., aged 55 years, married, Spanish descent, salesman in wholesale drygoods house. <h3>Family history.</h3> —Father is 82 years old and in good health, though he had a slight cerebral hemorrhage last winter, but entirely recovered. Mother died at 62 years of age, from fatty degeneration of heart and kidneys. The necroscopic report does not give any clue as to the cause. An elder brother died, at 57 years of age, from Addison's disease. One brother, still living, is 45 years old and in fair health. Two sisters died in childhood from scarlet fever. <h3>Patient's history.</h3> —Average weight 165 pounds, dark and sallow complexion and troubled with chronic constipation; moderate smoker and user
Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations
Authors: Nadia Jeremiah, Bénédicte Neven, Matteo Gentili, Isabelle Callebaut, Sophia Maschalidi, Marie-Claude Stolzenberg, Nicolas Goudin, Marie-Louis Frémond, Patrick Nitschke, Thierry J. Molina, Stéphane Blanche, Capucine Picard, Gillian I. Rice, Yanick J. Crow, Nicolas Manel, Alain Fischer, Brigitte Bader-Meunier, Frédéric Rieux-Laucat
Journal: Journal of Clinical Investigation (2014)

Innate immunity to viral infection involves induction of the type I IFN response; however, dysfunctional regulation of this pathway leads to inappropriate inflammation. Here, we evaluated a nonconsanguineous family of mixed European descent, with 4 members affected by systemic inflammatory and autoimmune conditions, including lupus, with variable clinical expression. We identified a germline dominant gain-of-function mutation in TMEM173, which encodes stimulator of type I IFN gene (STING), in the affected individuals. STING is a key signaling molecule in cytosolic DNA-sensing pathways, and STING activation normally requires dimerization, which is induced by 2'3' cyclic GMP-AMP (cGAMP) produced by the cGAMP synthase in response to cytosolic DNA. Structural modeling supported constitutive activation of the mutant STING protein based on stabilized dimerization. In agreement with the model predictions, we found that the STING mutant spontaneously localizes in the Golgi of patient fibroblasts and is constitutively active in the absence of exogenous 2'3'-cGAMP in vitro. Accordingly, we observed elevated serum IFN activity and a type I IFN signature in peripheral blood from affected family members. These findings highlight the key role of STING in activating both the innate and adaptive immune responses and implicate aberrant STING activation in features of human lupus.
Egg and milk exclusion diets in atopic eczema
Authors: V.S. NEILD, R.A. MARSDEN, J.A. BAILES, J.M. BLAND
Journal: British Journal of Dermatology (1986)

Journal Article Egg and milk exclusion diets in atopic eczema Get access V.S. NEILD, V.S. NEILD Skin Department, St. George's Hospital, London, U.K. Dr V.S.Neild, Department of Dermatology, St. George's Hospital, Blackshaw Road, London SW17, U.K. Search for other works by this author on: Oxford Academic Google Scholar R.A. MARSDEN, R.A. MARSDEN Skin Department, St. George's Hospital, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.A. BAILES, J.A. BAILES Skin Department, St. George's Hospital, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar J.M. BLAND J.M. BLAND Department of Clinical Epidemiology and Social Medicine, St George's Hospital Medical School, London, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 114, Issue 1, 1 January 1986, Pages 117–123, https://doi.org/10.1111/j.1365-2133.1986.tb02786.x Published: 01 January 1986 Article history Accepted: 09 July 1985 Published: 01 January 1986
Ultrasound Examination of the Gallbladder
Authors: Royal J. Bartrum
Journal: JAMA (1976)

THE LONG-APPRECIATED problem of poor gallbladder visualization following a single dose of an orally administered contrast agent continues to stimulate controversy. None of the various orally administered agents consistently gives satisfactory opacification with standard dosage. Nearly everyone agrees that the traditional remedy of a "double dose" (actually a repeat single dose) is costly in both physician and patient time, as well as in increased radiation exposure. Some physicians advocate using a "double dose" initially.<sup>1,2</sup>Others believe that this is wasteful, because it subjects the majority of patients to unnecessary overdosage, and prefer diet modifications, oral cholecystogogues, or bile salts.<sup>3</sup> We believe that ultrasonic examination of the initially nonvisualized gallbladder is superior to any of these suggestions. <h3>Materials and Methods</h3> Fifty patients with a nonvisualized gallbladder following a single 3-gm dose of tyropanoate sodium (Bilopaque) were examined with a commercially available bistable B-scanner and a 2.25-MHz transducer. The ultrasound
Teaching Human Reproduction
Authors: R. W. Taylor
Journal: BMJ (1967)

Background: We previously developed a mouse model of breast cancer that mimics human triple-negative breast cancer (TNBC) by inactivating the Retinoblastoma (Rb), Transformation related protein 53 (p53), and Breast cancer 1 (Brca1) pathways in the mammary gland. Despite inactivation of all three tumor suppressors throughout the epithelium, low tumor multiplicity indicated that malignant carcinoma progression requires additional oncogenic stimuli. Materials and Methods: In order to identify collaborating genetic events, we performed integrated analysis of 18 tumors (eight tumors with inactivation of pRbf/Brca1/p53 and ten tumors with inactivation of pRbf/p53) using comparative genomic hybridization and global gene expression. We then conducted flow cytometric analysis, immunostaining, tumorsphere, and cell viability assays. Results: Copy number aberrations were correlated with the transcript levels of 7.55% of genes spanned by the altered genomic regions. Recurrent genomic losses spanning large regions of chromosomes 4 and 10 included several cell death genes. Among the amplified genes were well-known drivers of tumorigenesis including Wingless-related MMTV integration site 2 (Wnt2), as well as potentially novel driver mutations including the Late cornified envelope (LCE) gene family. These tumors have a stem/luminal progenitor phenotype and active β-catenin signaling. Tumorsphere formation and cell survival are suppressed by Wnt pathway inhibitors. Conclusion: Our novel mouse model mimics human TNBC and provides a platform to triage the pathways that underlie malignant tumor progression.
De l’hôpital psychiatrique-donjon au fief-secteur
Authors: C. Bardet-Giraudon
Journal: Psychotherapy and Psychosomatics (1978)

Research Articles| February 16 2010 De l'hôpital psychiatrique-donjon au fief-secteur Subject Area: Psychiatry and Psychology C. Bardet-Giraudon C. Bardet-Giraudon Epinay-sur-Orge Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1978) 29 (1-4): 104–106. https://doi.org/10.1159/000287108 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation C. Bardet-Giraudon; De l'hôpital psychiatrique-donjon au fief-secteur. Psychother Psychosom 31 December 1978; 29 (1-4): 104–106. https://doi.org/10.1159/000287108 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search Article PDF first page preview Close Modal 1978Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Abstract 3440: Activation of hedgehog pathway in tumor vasculature is a late event of pancreatic tumorigenesis
Authors: JUNPEI SASAJIMA, Yusuke Mizukami, Kazumasa Nakamura, Yoshiaki Sugiyama, Toru Kawamoto, Kazuya Koizumi, Kazuya Sato, Satoshi Tanno, Mikihiro Fujiya, Norihiko Shimizu, Karasaki Hidenori, Toru Kono, Masaaki Ii, Daniel C. Chung, Nabeel Bardeesy, Yutaka Kohgo
Journal: Cancer Research (2010)

Abstract Bone marrow cells can be activated to function as instigators of tumor growth by systemic tumor-derived signals. We have identified subsets of BM cells that regulate neovascularization in pancreatic ductal adenocarcinoma (PDAC). Notably, blockade of Hedgehog (Hh) signaling markedly destabilized neovessels in PDAC xenografts by attenuating the homing and incorporation of the BM-derived cells into the neovasculature. We found IGF-1 production in the tumor stroma was regulated by the Hh ligand, Shh, and played a key role during this process. In vitro co-culture experiments demonstrated that human PDAC cell lines induced IGF-1 in c-Kit+ BM derived mononuclear cells utilized as pro-angiogenic cells, and that the induction was attenuated either by cyclopamine or expression of shRNA targeting Smo in the mononuclear cells. Shh secreted from PDAC cells induced tube formation by the mouse endothelial line MS-1, suggesting an important role for Shh in migration and capillary formation of the BM-derived pro-angiogenic cells; this induction of capillary morphogenesis was blocked by anti-IGF-1 neutralizing antibody. The “paracrine” effect of Hh seems to be a late event during pancreatic tumorigenesis, as full length Gli2 expression in neovasculatures was detected within PDAC lesions, but not in precursor PanIN lesions using a genetically engineered mouse models. We also observed upregulation of VE-cadherin, Id1, and Ptch1 mRNA in lineage-/c-Kit+ fraction of BM mononuclear cells from PDAC mice as compared to control mice or mice with PanIN, suggesting that pro-angiogenic conditions induced at the level of the BM in cancer-bearing hosts. The primitive progenitors derived from ‘activated BM’ are imported to the tumor microenvironment where they become fully activated. Overall, these studies provide insights into the cellular and molecular mechanisms by which BM-derived cells promote tumor growth and angiogenesis and have implications for the design of anti-angiogenesis therapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3440.
NON-STEROIDAL ANTI-INFLAMMATORY DRUG, LOXOPROFEN, PREVENTS ATRIAL FIBRILLATION RECURRENCE IMMEDIATELY AFTER PULMONARY VEIN ISOLATION ABLATION
Authors: Atsunobu Kasai, Shigetoshi Sakabe, Keishi Moriwaki, Kiyotaka Watanabe, Takeshi Takamura, Takashi Omura, Akihiro Kawamura, Tetsuya Seko
Journal: Journal of the American College of Cardiology (2011)
Pathology and Laboratory Medicine
Authors: Susan J. Maygarden, William W. McLendon
Journal: JAMA (1991)

Modern clinical treatment protocols demand precise diagnoses. While traditional hematoxylineosin slides continue to be the primary tool for histopathological diagnoses, these are no longer sufficient for the diagnosis and treatment of many patients. Pathologists are now using many supplemental approaches to provide more complete and valid information for patient care. While diagnoses are requiring increasing sophistication, the amount of tissue available for study by the pathologist is continually decreasing. In the past, most specimens were large, surgically resected masses or open biopsy specimens. Today, the mix of specimens has shifted toward small biopsy specimens, fine-needle aspirations, and other cytological preparations. Thus, the pathologist is faced with the challenge of using highly sophisticated techniques to obtain the maximum information from increasingly small samples from the patient. In this article, we will discuss some of the new knowledge and modern diagnostic techniques that aid the pathologist in meeting this challenge, especially molecular
The Impact of Health Maintenance Organizations on Geriatric Care
Authors: MURIEL R. GILLICK
Journal: Annals of Internal Medicine (1987)

Increasing numbers of health maintenance organizations (HMOs) are contracting with the federal government to permit enrollment of Medicare beneficiaries, and increasing numbers of the elderly are joining HMOs. A review of past HMO performance suggests that, although these organizations will try to effect a decrease in the rate and duration of hospitalization to control costs, a high rate of functional disability and acute illness in elderly patients will make it impossible to accomplish this significantly. Also, although HMOs will attempt to provide more comprehensive coverage, the demand for prescription drugs, eyeglasses, and medical devices will make such coverage very expensive. Attempts to ration the services of primary-care physicians will impede case management and continuity of care. If HMOs are to provide high-quality medical care at a reasonable cost, they will need to consider making use of geriatric assessment units, geriatric consultants, geriatric nurse practitioners, and special geriatric hospital wards.
Prostate&amp;ndash;Specific Antigen (PSA) Value Change after Antibacterial Therapy of Prostate Inflammation, as a Diagnostic Method for Prostate Cancer Screening in Cases of PSA Value within 4&amp;ndash;10 ng&amp;sol;ml and Nonsuspicious Results of Digital Rectal Examination
Authors: Guram Karazanashvili, Laurent Managadze
Journal: European Urology (2001)
Circulating Anticoagulant in the Acquired Immunodeficiency Syndrome
Authors: Jean Jacques Lefrère, Danielle Gozin, Jacques Modai, Daniel Vittecoq
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 September 1987Circulating Anticoagulant in the Acquired Immunodeficiency SyndromeJEAN JACQUES LEFRÈRE, M.D., DANIELLE GOZIN, Ph.D., JACQUES MODAI, M.D., DANIEL VITTECOQ, M.D.JEAN JACQUES LEFRÈRE, M.D.Search for more papers by this author, DANIELLE GOZIN, Ph.D.Search for more papers by this author, JACQUES MODAI, M.D.Search for more papers by this author, DANIEL VITTECOQ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-2-429_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The prevalence of circulating anticoagulants has previously been reported to be high in patients with the acquired immunodeficiency syndrome (AIDS), particularly in those with Pneumocystis carinii pneumonia (1, 2). We report the findings of a prospective study on this subject.During a 6-month period, 25 nonhemophiliac patients with AIDS (23 homosexual men, 1 drug addict, and 1 person who had received a blood transfusion) who fulfilled the Centers for Disease Control criteria, were included in the study. Ages ranged from 21 to 42 years (mean, 32). All had a markedly decreased T4/T8 ratio (mean, 0.12) and low...References1. COHENPHILIPSKESSLER ATC. Circulating coagulation inhibitors in the acquired immunodeficiency syndrome. Ann Intern Med. 1986;104:175-80. LinkGoogle Scholar2. GOLDHAUBENSTOCKZALUSKI JAR. Lupus anticoagulant and AIDS. N Engl J Med. 1986;314:1252-3. CrossrefMedlineGoogle Scholar3. BLOOMABRAMSRODGERS EDG. Lupus anticoagulant in the acquired immunodeficiency syndrome. JAMA. 1986;256:491-3. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByNanobioaerosols—reconsidering agricultural irrigation in a warming worldNoninfectious Manifestations of Human Immunodeficiency Virus InfectionAnticardiolipin antibodies (ACA) are most often not associated with lupus-like anticoagulant (LLAC) in human immunodeficiency virus (HIV) infectionHematologic Abnormalities in AIDSHemostatic Abnormalities in HIV DiseaseCirculating anticoagulant in patients seropositive for human immunodeficiency virusRheumatologic Manifestations of Infection with Human Immunodeficiency Virus (HIV)Brian R. Kaye, MDLUPUS ANTICOAGULANT ASSOCIATED WITH HIV INFECTIONAnticardiolipin antibody in the acquired immunodeficiency syndrome: a marker of Pneumocystis carinii infection?Hematologic aspects of human immunodeficiency virus infection: Laboratory and clinical considerations 1 September 1987Volume 107, Issue 3Page: 429-430KeywordsAIDSAddictsAnticoagulantsBlood transfusionHomosexualsPneumocystis carinii pneumoniaProspective studies Issue Published: 1 September 1987 PDF DownloadLoading ...
Alcohol vs. Ammonia in the Treatment of Pneumonia, with a Few Thoughts on the Physiologic Effects of Alcohol.
Authors: Daniel E. Keefe
Journal: JAMA (1902)

Springfield, Mass, August 2, 1902. <h3>To the Editor:</h3> —While the paper of Dr. N. S. Davis, Jr., in your issue of July 5, 1902, contains much that is both interesting and instructive, his treatment of the subject of "diffusible stimulants" not only leaves much to be desired, but also invites criticism. With those who totally eschew stimulants in the treatment of pneumonia, I make no contest, having myself adverted to their inutility in the<i>Philadelphia Medical Journal</i>of March 3, 1901, but with one preferring ammonia to alcohol in this disease and for the reasons given I am compelled not only to disapprove the choice but to deny the correctness of the premises upon which it is based. The reasons given may be succinctly stated about as follows: "Alcohol is not a food, isirritating to the stomach, disturbs metabolism, hastens muscular degeneration, is very ephemeral in its action, promotes cyanosis,
Long-term tri- and tetra-cyclic antidepressants, myocardial contractility, and cardiac rhythm.
Authors: E A Raeder, D Burckhardt, H Neubauer, R Walter, M Gastpar
Journal: BMJ (1978)

Thyrotoxic Graves's disease after primary hypothyroidismWe report a case of thyrotoxicosis following primary hypothyroidism in a 61-year-old man. Case report CommentThis survey shows that Dixarit may cause severe and lifethreatening symptoms, particularly in young children.Although no deaths occurred, obviously measures should be taken to prevent future incidents.The high incidence of poisoning by Dixarit, in contrast to Catapres, may lie in its attractiveness for the young, resulting from its on 16 August
Current Status of Therapy of the Menopause
Authors: Joseph Rogers
Journal: JAMA (1961)

THE RAPID increase in life expectancy of women and the increasing proportion of older persons in the population have stimulated increased attention to the proper management of the menopause. It seems appropriate to discuss not only the therapeutic problems arising at the time of cessation of the menses but also the management of the post-menopausal state.  The fundamental change at the menopause is a decreasing frequency of ovulation followed later by a decline in estrogen production by the ovary. These events are reflected clinically by a change in the menses which may consist of sudden cessation of normal periods, irregular and profuse menstruation, or scanty and infrequent periods. Eventually permanent amenorrhea ensues. The other classic symptom of the menopause is the hot flash, which is usually described as a sudden sensation of heat in the face, neck, and chest associated with diffuse or patchy flushing of the skin, and