tbuckley/cabot-search huggingface dataset:
PARASTERNAL CHONDRODYNIA (TIETZE'S SYNDROME)
Authors: N BARNES, J GRAHAM
Journal: Annals of Internal Medicine (1959)

Article1 July 1959PARASTERNAL CHONDRODYNIA (TIETZE'S SYNDROME)NEALE BARNES, M.D., JAMES GRAHAM, M.D.NEALE BARNES, M.D.Search for more papers by this author, JAMES GRAHAM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-1-57 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAs more reports of a particular clinical state are recorded, it becomes necessary to review the available pertinent data and to make appropriate changes in concept. This is the situation with the clinical entity which has been called Tietze's syndrome.1This syndrome was described originally in the German literature and later reported throughout Europe. However, to date only nine cases have been recorded in the American literature, and it is our belief that this small number does not reflect the true incidence of this curious syndrome. Moreover, certain features of the illness appear consistently and justify the adoption of a...Bibliography1. MotulskyRohn AGRR: Tietze's syndrome: cause of chest pain and chest wall swelling, J. A. M. A. 152: 504-506, 1953. CrossrefMedlineGoogle Scholar2. Wehrmacher WH: Significance of Tietze's syndrome in differential diagnosis of chest pain, J. A. M. A. 157: 505-507, 1955. CrossrefMedlineGoogle Scholar3. Bernreiter M: Tietze's syndrome, Ann. Int. Med. 45: 132-134, 1956. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Springfield, Illinois*Received for publication January 29, 1958.Requests for reprints should be addressed to Neale Barnes, M.D., 1025 South Seventh Street, Springfield, Illinois. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySternocostal Joint Swelling–Clinical Tietze's SyndromeRadiographic findings in patients with clinical Tietze syndromeReliability of computed tomography in the initial diagnosis and follow-up evaluation of Tietze's syndrome: Case report with review of the literatureRheumatism and Arthritis Review of American and English Literature of Recent Years (Fourteenth Rheumatism Review)CHARLEY J. SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., CHARLES L. CHRISTIAN, M.D., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., EDWARD C. FRANKLIN, M.D., DONALD F. HILL, M.D., F.A.C.P., JOSEPH L. HOLLANDER, M.D., F.A.C.P., HOWARD L. HOLLEY, M.D., F.A.C.P., JOHN G. MAYNE, M.D., WILLIAM M. MIKKELSEN, M.D., CHARLES L. SHORT, M.D., F.A.C.P., HUGH A. SMYTHE, M.D., F.R.C.P.(C), OTTO STEINBROCKER, M.D., HOWARD J. WEINBERGER, M.D. 1 July 1959Volume 51, Issue 1Page: 57-59 Issue Published: 1 July 1959 PDF downloadLoading ...
Aspirin, Ibuprofen, and the Risk of Colorectal Cancer in Lynch Syndrome
Authors: Driss Ait Ouakrim, Seyedeh Ghazaleh Dashti, Rowena Chau, Daniel D. Buchanan, Mark Clendenning, Christophe Rosty, Ingrid M. Winship, Joanne P. Young, Graham G. Giles, Barbara Leggett, Finlay A. Macrae, Dennis J. Ahnen, Graham Casey, Steven Gallinger, Robert W. Haile, Loïc Le Marchand, Stephen N. Thibodeau, Noralane M. Lindor, Polly A. Newcomb, John D. Potter, John A. Baron, John L. Hopper, Mark A. Jenkins, Aung Ko Win
Journal: JNCI Journal of the National Cancer Institute (2015)

Inheritance of a germline mutation in one of the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 causes a high risk of colorectal and other cancers (Lynch Syndrome). Use of aspirin has been shown to be associated with a reduced risk of colorectal cancer for the general population as well as for MMR gene mutation carriers. The aim of this study was to determine whether use of aspirin and ibuprofen in a nontrial setting is associated with the risk of colorectal cancer risk for MMR gene mutation carriers. We included 1858 participants in the Colon Cancer Family Registry who had been found to have a pathogenic germline mutation in a MMR gene (carriers). We used weighted Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). All statistical tests were two-sided. A total of 714 carriers (38%) were diagnosed with colorectal cancer at a mean age of 42.4 (standard deviation 10.6) years. A reduced risk of colorectal cancer was associated with aspirin use (for 1 month to 4.9 years: HR = 0.49, 95% CI = 0.27 to 0.90, P = .02; for ≥5 years: HR = 0.25, 95% CI = 0.10 to 0.62, P = .003) and ibuprofen use (for 1 month to 4.9 years: HR = 0.38, 95% CI = 0.18 to 0.79, P = .009; for ≥5 years: HR = 0.26, 95% CI = 0.10 to 0.69, P = .007), compared with less than one month of use. Our results provide additional evidence that, for MMR gene mutation carriers, use of aspirin and ibuprofen might be effective in reducing their high risk of colorectal cancer.
Neuromuscular training injury prevention strategies in youth sport: a systematic review and meta-analysis
Authors: Carolyn A Emery, Thierry-Olivier Roy, Jackie L Whittaker, Alberto Nettel-Aguirre, Willem van Mechelen
Journal: British Journal of Sports Medicine (2015)

Youth have very high participation and injury rates in sport. Sport is the leading cause of injury in youth. Sport injury reduces future participation in physical activity which adversely affects future health. Sport injury may lead to overweight/obesity and post-traumatic osteoarthritis. The objective of the systematic review and meta-analysis was to evaluate the efficacy of injury prevention neuromuscular training strategies in youth sport. Three electronic databases were systematically searched up to September 2014. Studies selected met the following criteria: original data; analytic prospective design; investigated a neuromuscular training prevention strategy intervention(s) and included outcomes for injury sustained during sport participation. Two authors assessed the quality of evidence using Downs and Black (DB) criteria. Meta-analyses including randomised controlled trials only (RCTs) to ensure study design homogeneity were completed for lower extremity and knee injury outcomes. Of 2504 potentially relevant studies, 25 were included. Meta-analysis revealed a combined preventative effect of neuromuscular training in reducing the risk of lower extremity injury (incidence rate ratio: IRR=0.64 (95% CI 0.49 to 0.84)). Though not statistically significant, the point estimate suggests a protective effect of such programmes in reducing the risk of knee injury (IRR=0.74 (95% CI 0.51 to 1.07)). There is evidence for the effectiveness of neuromuscular training strategies in the reduction of injury in numerous team sports. Lack of uptake and ongoing maintenance of such programmes is an ongoing concern. A focus on implementation is critical to influence knowledge, behaviour change and sustainability of evidence informed injury prevention practice.
Phase II trial of gefitinib in patients with incurable salivary gland cancer
Authors: B. S. Glisson, G. Blumenschein, M. Francisco, J. Erasmus, R. Zinner, M. Kies
Journal: Journal of Clinical Oncology (2005)

5532 Background: Conventional chemotherapy agents offer little efficacy for patients with incurable salivary gland cancer. EGFR (her1) overexpression has been identifed in > 90% of salivary gland cancers in recent series. Thus, EGFR-targeted therapy with gefitinib offers promise in treatment of this disease. Methods: From 6/04 to 12/04 28 patients with incurable salivary gland cancer were accrued to a phase II trial of gefitinib (250 mg po daily). Eligibility: ECOG PS 0–2, measurable disease, no prior EGFR inhiibitors. Patients were accrued in two cohorts: (1) adenoid cystic and (2) other histologies. Primary endpoint was response rate based on RECIST criteria and imaging every 2 months. Analysis of EGFR and her2 expression (IHC) on archival tumor was a secondary endpoint. Results: Patient characteristics, number(%): PS 1 26(93), M 19(68), prior chemotherapy 6(21), adenoid cystic 19(68), adenocarcinoma 3(11), salivary duct 3(11), mucoepidermoid 2(7), and undifferentiated 1(3). Twenty-six patients received 71 courses. Two are in their first course. Toxicity (26 pts), number (%): grade 1 diarrhea 20(77), grade 1/2 rash 14(54), grade 1/2 anorexia 8(31), grade 1/2 fatigue 14(54), grade 1 nausea 4(15), grade 1 mucositis 4(15), grade 1 nail change 2(8). No grade 3–4 effects observed. Three patients discontinued therapy due to grade1–2 effects that were felt treatment-related in only 1/3. Response (21 pts), number(%): CR/PR 0(0), SD 14 (67), PD 7(33). 13/14 pts with SD have adenoid cystic cancer. Median duration of SD: 13 wks (4–19). One pt is dead of disease, two have died from other causes. Accrual to the adenoid cystic cohort is complete unless a reponse is observed. Accrual to the other cohort is ongoing. Conclusions: Gefitinib was well-tolerated and led to a high rate of SD in adenoid cystic cancer. Given the frequent indolent nature of salivary gland cancer, interpretation of the value of SD requires further f/u. This will be updated and expression of EGFR and her2 will be presented. No significant financial relationships to disclose.
Effectiveness of combined pulsed dye and Q-switched ruby laser treatment for large to giant congenital melanocytic naevi
Authors: E. Funayama, S. Sasaki, H. Furukawa, T. Hayashi, T. Yamao, K. Takahashi, Y. Yamamoto, A. Oyama
Journal: British Journal of Dermatology (2012)

There is no consensus on the most appropriate treatment for patients with large to giant congenital melanocytic naevi (CMN) because of the risk of melanoma development. Surgical excision followed by skin grafting or expanded skin coverage may cause unfavourable scarring. There is a balance to be achieved between minimizing the disfiguring appearance and the risk of malignant change. The pulsed dye laser (PDL) is commonly used for vascular lesions and is highly absorbed by melanin and haemoglobin. Its pulse duration is longer than that of Q-switched ruby lasers (QsRL), which can have nonspecific photothermolytic effects on surrounding nonpigmented naevus cells.To investigate the effectiveness of combined treatment with the PDL and QsRL for large to giant CMN.Six patients with large to giant CMN were enrolled in this study. Treatment consisted of one pass of PDL treatment followed by one pass of QsRL treatment. Multiple rounds of treatment were applied to all patients.All patients responded to this combined regimen, and the lesional colour was effectively reduced. The mean number of rounds of laser treatment required to achieve skin lightening was 7·7. No patients suffered severe hypertrophic scarring. No cases of recurrence or malignant transformation were observed. The histological results from the patient who underwent the most laser therapy in this study showed a remarkable reduction in the number of melanocytic naevus cells after treatment.This technique may enable the removal of most of the pigmented lesion and melanocytic naevus cells with minimal scarring.
Induction chemotherapy and concomitant chemoradiotherapy (CRT) in patients with unresectable, locally advanced pancreatic carcinoma
Authors: M. Kurt, E. Kurt, S. K. Cetintas, T. Evrensel, O. Manavoglu, K. Engin
Journal: Journal of Clinical Oncology (2004)

4164 Background: The aim of our study was to evaluate the efficacy of chemoradiotherapy (CRT) in patients with unresectable locally advanced pancreatic cancer.Methods: Patients with unresectable, locally advanced pancreatic carcinoma were administered with induction chemotherapy consisted of 5-FU (500 mg/m2, iv bolus, days 1+8+15) and gemcitabine (1000 mg/m2, iv, days 1+8+15). A second course of the regimen was started on the 28th day. The patients who did not have any metastasis after the second course of induction chemotherapy were entered in the CRT phase which was consisted of gemcitabine (350 mg/m2, weekly, during radiotherapy) plus radiotherapy (5400 cGy, 30 fractions, 5 days a week). Patients who achieved response or stabilization with induction chemotherapy were administered 2 additional cycles of the same combined chemotherapy regimen after CRT. Response was evaluated by radiological examinations.Results: Fourteen patients were enrolled in the study. After the completion of the treatments, response was observed in 2 patients (1 CR, 1 PR; ORR %14.28) and stabile disease was observed in 3 patients (%21.42). Grade 3 myelosupression was observed in 3 patients (%21.42). No other Grade ¾ toxicities were observed. The median survival of the patients was 17 (4–40) months.Conclusions: Induction chemotherapy and concomitant CRT according to the current schedule is well tolerated and active treatment of unresectable, locally advanced pancreatic cancer. No significant financial relationships to disclose.
Clinical cardiotoxicity following anthracycline treatment for childhood cancer: the Pediatric Oncology Group experience.
Authors: J P Krischer, S Epstein, D D Cuthbertson, A M Goorin, M L Epstein, S E Lipshultz
Journal: Journal of Clinical Oncology (1997)

PURPOSE To determine the incidence of clinical cardiotoxicity from anthracycline chemotherapy in children with cancer and to identify associated risk factors. PATIENTS AND METHODS The study population consisted of 6,493 children with cancer who had received anthracycline chemotherapy on Pediatric Oncology Group (POG) protocols from 1974 to 1990. Cardiotoxicity, defined as congestive heart failure not due to other causes, abnormal measurements of cardiac function that prompted discontinuation of therapy, or sudden death from presumed cardiac causes, was determined by a review of protocol records. RESULTS Cardiotoxicity was confirmed in 106 patients (1.6%): 58 had congestive heart failure, 43 had changes in measures of cardiac function that prompted the discontinuation of therapy, and five died suddenly from presumed cardiac causes. In a multivariate analysis, factors that contributed to the relative risk (RR) of toxicity were a cumulative anthracycline dose &gt; or = 550 mg/m2 of body-surface area (RR = 5.2), maximal dose &gt; or = 50 mg/m2 (RR = 2.8), female sex (RR = 1.9), black race (RR = 1.7), presence of trisomy 21 (RR = 3.4), and exposure to amsacrine (RR = 2.6). Cardiotoxicity within 1 year after the completion of anthracycline treatment (early cardiotoxicity) represented 89.5% of all cases. CONCLUSION Early clinical cardiotoxicity in children treated with anthracycline is rare. A high maximal dose, or cumulative dose of anthracycline, female sex, black race, presence of trisomy 21, and treatment with amsacrine increase the risk for anthracycline-associated cardiotoxicity.
Left and right ventricular function in obstructive sleep apnea patients: Echocardiographic speckle tracking strain analysis of CPAP therapy effects
Authors: Bouchra Lamia, Stéphanie Gelinotte, Florence Portier, Luis-Carlos Molano, Catherine Tardif, Antoine Cuvelier, Jean-François Muir
Journal: European Respiratory Journal (2012)

Introduction  Obstructive sleep apnea is associated with right ventricular dysfunction including preload and afterload abnormalities. Right ventricular contractility remains difficult to assess due to the complex RV geometry. Echocardiographic speckle tracking strain provides a better understanding of regional contractility. We tested the hypothesis that RV dyssynchrony exists in OSA patients and can be reversed by CPAP therapy.  Methods  Prospective study including patients with a confirmed OSA diagnosis. Echocardiographic (TTE) measurements were obtained at baseline and after one month of CPAP therapy. We measured usual TTE parameters: left ventricular ejection fraction (LVEF), transmitral pulsed Doppler including E and A waves velocities, mitral Doppler tissue imaging. The speckle tracking analysis was used to generate 6 segmental RV strain curves. Time to peak strain was determined with dyssynchrony defined as the difference between earliest and latest segments. Global radial strain was calculated.  Results  36 patients (M: 69%,mean (SD) age 56(11) yrs, body mass index 35.11(7.38) kg/m-2, respiratory disturbance index 46(18)/h) were included. At baseline, 56% had high blood pressure, 22% had a chronic heart disease, with a normal LVEF: 61(8) %. Speckle tracking strain analysis showed RV dysfunction with a decreased RV global strain: 13.8(5.8) % and RV dyssynchrony: 174 (89) ms. After one month of CPAP, RV function was significantly improved and dyssynchrony was reversed: 125 (82) ms, p=0.03.  Conclusion  We observed RV dyssynchrony at baseline in OSA patients. RV dyssynchrony was improved after one month of CPAP therapy.
Effects of Aflatoxin B1 on Pregnant Inbred Sprague-Dawley Rats and Their F1 Generation. A Contribution to Transplacental Carcinogenesis23
Authors: Klaus Goerttler, Heinz Löhrke, Hans-Jürgen Schweizer, Brigitte Hesse
Journal: JNCI Journal of the National Cancer Institute (1980)

Journal Article Effects of Aflatoxin B1 on Pregnant Inbred Sprague-Dawley Rats and Their F1 Generation. A Contribution to Transplacental Carcinogenesis Get access Klaus Goerttler, Klaus Goerttler Search for other works by this author on: Oxford Academic PubMed Google Scholar Heinz Löhrke, Heinz Löhrke Search for other works by this author on: Oxford Academic PubMed Google Scholar Hans-Jürgen Schweizer, Hans-Jürgen Schweizer Search for other works by this author on: Oxford Academic PubMed Google Scholar Brigitte Hesse Brigitte Hesse Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 64, Issue 6, June 1980, Pages 1349–1354, https://doi.org/10.1093/jnci/64.6.1349 Published: 01 June 1980 Article history Received: 27 November 1978 Revision received: 17 September 1979 Accepted: 22 September 1979 Published: 01 June 1980
Ellipticine-Induced changes in Cell Growth and Nuclear Morphology<xref ref-type="fn" rid="fn2">2</xref>
Authors: F Traganos, D P Evenson, L Staiano-Coico, Z Darzynkiewicz, M R Melamed
Journal: JNCI Journal of the National Cancer Institute (1980)

Twenty-four-hour exposure of Friend leukemia (FL) and L1210 cells to 1.0 micrograms ellipticine/ml resulted in a slowdown in cell proliferation, accumulation of cells in G2 phase, an increase in cellular RNA content, and an increase in the proportion of cells with greater than 4C (tetraploid) content of DNA in both cell lines. Removal of the drug and subsequent cell culturing in fresh medium for 24 hours led to a further increase in the proportion of cells having more than a 4C content of DNA, with no change in cell number, in FL cell cultures. Distinct micronucleation and an increase in cell size without any sign of cell division were seen in FL cells so treated. In contrast, L1210 cells after transfer to fresh medium reentered the normal cell cycle, continued to proliferate, and demonstrated only a slight increase in cells with greater than a 4C content of DNA within 24 hours of removal of the drug.
Phylogenetic relationships of amphibian families inferred from DNA sequences of mitochondrial 12S and 16S ribosomal RNA genes.
Authors: J M Hay, I Ruvinsky, S B Hedges, L R Maxson
Journal: Molecular Biology and Evolution (1995)

Nucleotide sequence comparisons were used to investigate ordinal and familial relationships within the class Amphibia. Approximately 850 base pairs of the mitochondrial 16S ribosomal RNA (rRNA) gene from representatives of 28 of the 40 families of extant amphibians were sequenced. Phylogenetic analyses of these data together with published data of the 12S rRNA gene for the same families and both genes for three more taxa (approximately 1,300 base pairs total for 35 taxa) support the monophyly of each of the three amphibian orders: Anura (confidence value with the interior-branch test: P(c) = 99%), Caudata (P(c) = 100%), and Gymnophiona (P(c) = 99%). An analysis using the four-cluster method cannot discriminate significantly between all three possible unrooted trees involving the three orders of amphibians and an outgroup. Within the Anura, there is support for the monophyly of the two suborders: Neobatrachia (P(c) = 100%) and Archaeobatrachia (P(c) = 97%); the latter was believed to be paraphyletic on the basis of morphology. Within the Archaeobatrachia, the following pairs of taxa cluster: Pelobatidae + Pelodytidae (P(c) = 99%), Pipidae + Rhinophrynidae (P(c) = 99%), Ascaphus + Leiopelmatidae (P(c) = 89%), and Bombina + Discoglossidae (P(c) = 99%). The latter six taxa cluster (P(c) = 94%) such that Pelobatidae + Pelodytidae forms a basal lineage within the Archaeobatrachia. Three major lineages are distinguished within the Neobatrachia: the superfamily Bufonoidea sensu Duellman (P(c) = 86%), the superfamily Ranoidea sensu Lynch (P(c) = 99%), and the Sooglossidae. Basal within the Bufonoidea, Myobatrachidae + Heleophrynidae cluster at P(c) = 96%. The enigmatic Dendrobatidae clusters with the bufonoid families (P(c) = 92%) and is excluded from the ranoid families (P(c) = 99%). (ABSTRACT TRUNCATED AT 250 WORDS)
Fortnightly Review: Fungal nail disease: a guide to good practice (report of a Working Group of the British Society for Medical Mycology)
Authors: D W Denning, E G V Evans, C C Kibbler, M D Richardson, M M Roberts, T R Rogers, D W Warnock, R E Warren
Journal: BMJ (1995)

points * Onychomycosis is usually caused by dermatophytes (85-90%), but several fungi that are difficult to treat affect toenails * Paronychia is caused by many Candida species, some resistant to azole drugs * Samples for mycology should be taken as proximally as possible in the nail * Demonstration of hyphae in a nail specimen by microscopy is sufficient to start treatment * Choice of treatment depends on many factors including patient's age and preference, infecting fungus, number of nails affected, degree of nail involvement, whether toenails or fingernails are infected, and other drugs being taken
A randomised, concentration-controlled, comparison of standard (5-day) vs. prolonged (15-day) infusions of etoposide phosphate in small-cell lung cancer
Authors: S. Joel, K. O’Byrne, R. Penson, D. Papamichael, A. Higgins, H. Robertshaw, R. Rudd, D. Talbot, M. Slevin
Journal: Annals of Oncology (1998)
Medially constrained deformable modeling for segmentation of branching medial structures: Application to aortic valve segmentation and morphometry
Authors: Alison M. Pouch, Sijie Tian, Manabu Takebe, Jiefu Yuan, Robert Gorman, Albert T. Cheung, Hongzhi Wang, Benjamin M. Jackson, Joseph H. Gorman, Robert C. Gorman, Paul A. Yushkevich
Journal: Medical Image Analysis (2015)
Can subjects with a positive allergen skin test be selected by a short questionnaire?
Authors: N. H. Nielsen, A. Dirksen, F. Madsen
Journal: Allergy (1993)

The objective was to evaluate a postal questionnaire screening procedure for selection of subjects with positive reactions to skin prick tests with common allergens. The project consisted of a screening, with subsequent skin prick test of two selected groups. The setting was the Glostrup Population Studies institute in Copenhagen, Denmark. Participants in the screening included 8000 subjects, aged 15–69 years. The subjects were randomly selected from the population of western Copenhagen County, Denmark. From the 6998 respondents (87.5%), 793 subjects were randomly selected (Random Group), and 788 subjects were chosen on the basis of their answers to the questionnaire (Symptom Group). Both groups were invited to take skin prick tests. Attendance rates were 75.5% (Random Group) and 80.6% (Symptom Group). The main outcome measures were responses (yes or no) to the specific questions and the subjects' skin reaction (positive or negative). The association between symptoms and skin reactivity, adjusted for the effects of sex and age, was summarized by odds ratios. Symptoms on exposure to allergens were highly associated with positive skin reactivity. In the Symptom Group the percentage of subjects with at least one positive skin reaction was 57.7%, which was twice as much (28.4%) as in the Random Group. The results show that it was possible to select a group with high skin reactivity on the basis of the symptoms reported in the screening. Questions about exposure to allergens were the most appropriate for selection of this group.