Erythrocythemia and Neoplastic Tumors
Authors: ROBERT M. DONATI
Journal: Annals of Internal Medicine (1963)

Article1 January 1963Erythrocythemia and Neoplastic TumorsROBERT M. DONATI, M.D., JOHN M. MCCARTHY, M.D., ROBERT D. LANGE, M.D., F.A.C.P., NEIL I. GALLAGHER, M.D.ROBERT M. DONATI, M.D.Search for more papers by this author, JOHN M. MCCARTHY, M.D.Search for more papers by this author, ROBERT D. LANGE, M.D., F.A.C.P.Search for more papers by this author, NEIL I. GALLAGHER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-1-47 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptErythrocythemia has been observed in patients with several types of malignant and non-malignant tumors (1-65). Hematologic remissions following extirpation of the tumor (1-8, 10-14, 29-39, 60, 61) have suggested a causal relationship apparently due to elaboration of an erythropoietic factor by the neoplastic tissue. This report details observations made in 4 patients with erythrocythemia in association with undifferentiated carcinoma of the lung, hepatic cell carcinoma, or renal cell carcinoma. Plasma obtained from 3 of these patients exhibited erythropoietic stimulating activity.MATERIALS AND METHODSClinical summaries are recorded below. Only pertinent historical data, physical findings, and diagnostic examinations are included. Results...References1. THOMSONMARSON APFG: Polycythaemia with fibroids. Lancet 2: 759, 1953. CrossrefGoogle Scholar2. HORWITZMCKELWAY AWP: Polycythemia associated with uterine myomas. JAMA 158: 1360, 1955. CrossrefMedlineGoogle Scholar3. ENGELSINGER HWK: Polycythemia with fibroids. JAMA 159: 190, 1955. CrossrefMedlineGoogle Scholar4. FLEMINGMARKLEY ARJC: Polycythemia associated with uterine myomas. Amer. J. Obstet. Gynec. 74: 677, 1957. CrossrefMedlineGoogle Scholar5. BABUNAGARDNERGREEN CGHRR: Erythrocytosis associated with a myomatous uterus. Amer. J. Obstet. 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GALLAGHER, M.D.Affiliations: St. Louis, MissouriFrom the Departments of Medicine, Schools of Medicine, St. Louis and Washington Universities, and the Radioisotope and Hematology Research Sections of the Veterans Administration Hospital, St. Louis, Missouri.Supported in part by United States Public Health Service grant H-2793.Requests for reprints should be addressed to Robert M. Donati, M.D., Veterans Administration Hospital, 915 North Grand Boulevard, St. Louis 6, Missouri. 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