COMPARISON OF CLINICAL AND LABORATORY FINDINGS IN ALLEGED AND TRUE HYPOTHYROIDISM
Authors: John A. Sheedy, Wendell F. Lienhard
Journal: Annals of Internal Medicine (1957)

Article1 December 1957COMPARISON OF CLINICAL AND LABORATORY FINDINGS IN ALLEGED AND TRUE HYPOTHYROIDISMJOHN A. SHEEDY, WENDELL F. LIENHARDJOHN A. SHEEDYSearch for more papers by this author, WENDELL F. LIENHARDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-6-1184 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAmong the various endocrine deficiency states, hypothyroidism has been one of the most frequently diagnosed entities. The striking signs and symptoms of myxedema are generally quite well known to physicians, and diagnosis has been regarded as relatively easy, even without laboratory studies. The possibility that there might be patients with only a few of the classic signs and symptoms of myxedema prompted much speculation and study. Plummer1has been credited with the recognition in 1917 of a group termed "euthyroid hypo-metabolism." It was noted that these patients often complained of lethargy, easy fatigability, nervousness, irritability, emotional instability, sensitivity to cold,...Bibliography1. Plummer , cited by Higgins, W. H.4 Google Scholar2. BenedictCollins FGWE: Clinical apparatus for measuring basal metabolism, Boston M. and S. J. 183: 449, 1920. CrossrefGoogle Scholar3. BoothbySandiford WMI: Basal metabolic rate determination, 1920, W. B. Saunders Co., Philadelphia. Google Scholar4. Higgins WH: Incipient hypothyroidism, J. A. M. A. 85: 1015, 1925. CrossrefGoogle Scholar5. ThompsonThompson WOPK: Low basal metabolism following thyrotoxicosis, J. Clin. Investigation 5: 471, 1928. CrossrefMedlineGoogle Scholar6. SalterBassettSappington WTAMTS: Protein bound iodine in blood; its relation to thyroid function in 100 clinical cases, Am. J. M. Sc. 202: 527, 1941. CrossrefGoogle Scholar7. WinklerLavietesRobbinsMan AWTACLEB: Tolerance to oral thyroid and reaction to intravenous thyroxin in subjects without myxedema, J. Clin. Investigation 22: 535, 1943. CrossrefMedlineGoogle Scholar8. WinklerRiggsThompsonMan AWDSKWEB: Serum iodine in hyperthyroidism, with particular reference to the effects of subtotal thyroidectomy, J. Clin. Investigation 25: 404, 1946. CrossrefGoogle Scholar9. PerlmutterRiggs MDS: Thyroid collection of radioactive iodine and serum protein bound iodine concentration in senescence, in hypothyroidism and in hypopituitarism, J. Clin. Endocrinol. 9: 430, 1949. CrossrefGoogle Scholar10. WernerHamiltonLeiferGoodwin SCHBELD: An appraisal of the radioiodine tracer technic as a clinical procedure in the diagnosis of thyroid disorders, J. Clin. Endocrinol. 10: 1054, 1950. CrossrefGoogle Scholar11. KurlandHamoulskyFreedberg GSMWAS: Studies in nonmyxedematous hypometabolism, J. Endocrinol. and Metabolism 15: 1354, 1955. CrossrefGoogle Scholar12. StarrSnipesLiebhold-Schueck PGR: Biologic effects of tri-iodothyronine in human subjects, J. Clin. Endocrinol. and Metabolism 15: 98, 1955. CrossrefGoogle Scholar13. BoothbySandiford WI: Normal values of basal or standard metabolism. A modification of the DuBois standard, Am. J. Physiol. 90: 290, 1929. Google Scholar14. SobelMayer AEAM: Improvements in the Schoenheimer-Sperry method for the determination of free cholesterol, J. Biol. Chem. 157: 255, 1945. CrossrefGoogle Scholar15. BakerHumphreySoley SBMMMH: The clinical determination of protein bound iodine, J. Clin. Investigation 30: 55, 1951. CrossrefMedlineGoogle Scholar16. ThurmanThompson FMWO: Low basal metabolism without myxedema, Arch. Int. Med. 46: 879, 1930. CrossrefGoogle Scholar17. HainesMussey SFRD: Certain menstrual disturbances associated with low basal metabolic rates without myxedema, J. A. M. A. 105: 557, 1935. CrossrefGoogle Scholar18. LowensteinBrugerHinton BEMJW: The protein bound plasma iodine in patients with thyroid disease, J. Clin. Endocrinol. 4: 268, 1944. CrossrefGoogle Scholar19. Watson BA: The hypothyroid state; a clinical entity, New York State J. Med. 54: 2045, 1954. MedlineGoogle Scholar20. RosenmanFriedmanByers RHMSO: Observations concerning metabolism of cholesterol on the hypo- and hyperthyroid, Circulation 5: 589, 1952. CrossrefMedlineGoogle Scholar21. McGee LC: Blood cholesterol in disturbances of the basal metabolic rate, Ann. Int. Med. 9: 728, 1935-36. LinkGoogle Scholar22. DuffyWheelerNovakEdwards BJTEPJHN: Comparison of thyroid function tests, Armed Forces M. J. 5: 995, 1954. MedlineGoogle Scholar23. FreedbergChalmovitzKurland ASBLGS: Thyroid function in normal and pathological states as revealed by radioactive iodine studies, Metabolism 1: 26, 1952. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 19, 1957.From the General Medical Service and Radioisotope Section, Radiology Service, Fitzsimons Army Hospital, Denver, Colorado.Requests for reprints should be addressed to John A. Sheedy, Lt. Colonel (MC), 437 West Elsmere Place, San Antonio 12, Texas. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1957Volume 47, Issue 6Page: 1184-1201KeywordsCholesterolClinical laboratoriesDiagnostic radiologyEmotionsHypothyroidismMedical servicesProteinsResearch laboratoriesSigns and symptomsThyroid ePublished: 1 December 2008 Issue Published: 1 December 1957 PDF downloadLoading ...