Subacute Yellow Atrophy of the Liver Following Ingestion of Cinchophen and Allied Compounds
Authors: Walter K. Grigg, Victor C. Jacobsen
Journal: Annals of Internal Medicine (1933)

Article1 April 1933Subacute Yellow Atrophy of the Liver Following Ingestion of Cinchophen and Allied CompoundsWALTER K. GRIGG, M.D., VICTOR C. JACOBSEN, M.D.WALTER K. GRIGG, M.D.Search for more papers by this author, VICTOR C. JACOBSEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-10-1280 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCinchophen was first introduced to therapeutics in 1908 by Nicolaier and Dohrn for the treatment of gout. Since then its use has been extended to arthritis in general and as an analgesic. Various closely allied chemical compounds and derivatives have been brought out from time to time until now there are many similar drugs on the market, and with the multiplicity of trade names it is doubtful whether persons using or prescribing them are fully acquainted with the toxicity which they possess. Rabinowitz1 has listed twenty in this group of remedies, and there are probably others.The toxicity of these...References1 RABINOWITZ MA: Toxic hepatitis and hepatolysis following use of atophan, Med. Clin. N. Am., 1928, xi, 1025-1041. Google Scholar2 EDITORIAL: Atrophy of the liver due to cinchophen preparations, Jr. Am. Med. Assoc., 1930, xcv, 345. Google Scholar3 SCHROEDER K: Cases of cinchophen poisoning, Ugesk. f. Laeger, Kobenh., 1922, lxxxiv, 1141-1152. Google Scholar4 REICHLE HS: Toxic cirrhosis of liver due to cinchophen, Arch. Int. Med., 1929, xliv, 281-288. CrossrefGoogle Scholar5 HITZENBERGER K: Verhandl. d. Gesellschaft der Aerzte in Wien., Wien. klin. Wchnschr., 1927, xl, 205-207. Google Scholar6 SINGER S: Discussion of paper by G. Schwarz, Schwerer Ikterus Nach Bilopten, Wien. klin. Wchnschr., 1927, xl, 238-239. Google Scholar7 LANGDON-BROWN W: Atophan derivatives in rheumatism, Brit. Med. Jr., 1926, ii, 37. CrossrefGoogle Scholar8 ANDERSONTETER SDDP: Acute yellow atrophy of liver following administration of oxyl iodide, Jr. Am. Med. Assoc., 1929, xciii, 93-95. CrossrefGoogle Scholar9 STACYVANZANT LJFR: Poisoning from cinchophen, Minn. Med., 1930, xiii, 327-328. Google Scholar10 RABINOWITZ MA: Atrophy of liver due to cinchophen preparations, Jr. Am. Med. Assoc., 1930, xcv, 1228-1233. CrossrefGoogle Scholar11 WELLSBASSOE HGP: Acute yellow atrophy of the liver, Jr. Am. Med. Assoc., 1905, xliv, 685-692. CrossrefGoogle Scholar12 WELLS HG: Delayed chloroform poisoning and allied conditions, Jr. Am. Med. Assoc., 1906, xlvi, 341-343. CrossrefGoogle Scholar13 SIMONDS JP: Mechanism of protective action of carbohydrate diet in phosphorus and chloroform poisoning, Arch. Int. Med., 1919, xxiii, 362-379. CrossrefGoogle Scholar14 ERVIN DM: Relation of glycogen to pathologic changes in pancreatic diabetes, Jr. Lab. and Clin. Med., 1919, v, 146-153. Google Scholar15 BODANSKY M: Effect of chloroform and phosphorus poisoning on carbohydrate tolerance, Jr. Biol. Chem., 1923, lviii, 515-522. CrossrefGoogle Scholar16 STEWARTVININGBIBBY MJCWJP: Subacute yellow atrophy of the liver in a case of syphilis following treatment with galyl, Proceedings of Path. Soc. of Great Britain and Ireland), Jr. Path. and Bact., 1919, xxiii, 120-122. Google Scholar17 Physician's Bulletin, Eli Lilly Co., 1929, lxviii, 17. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Albany, New York*Received for publication May 7, 1932.†From the Departments of Medicine and Pathology of Albany Medical College and Albany Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Advantages of Hepatic Injury and Jaundice in Certain Conditions, Notably the Rheumatic DiseasesA 1 April 1933Volume 6, Issue 10Page: 1280-1288KeywordsAdverse reactionsAnalgesicsArthritisAtrophyGoutHospital medicineIngestionLiverToxicity Issue Published: 1 April 1933 PDF downloadLoading ...