tbuckley/cabot-search huggingface dataset:
The 1997 Balanced Budget Act and Home Services Among Medicare Patients
Authors: Beth Han, Robin E Remsburg
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Plasma Endothelin-1, Cytokine, and Prostaglandin E2Levels in Sickle Cell Disease and Acute Vaso-Occlusive Sickle Crisis
Authors: Evangeline Graido-Gonzalez, James C. Doherty, Eric W. Bergreen, Gregory Organ, Margaret Telfer, Marvin A. McMillen
Journal: Blood (1998)
Abstract P2-13-23: The oncologic safety of nipple-areolar complex skin sparing mastectomy compared with skin sparing mastectomy: 8 years follow up results
Authors: Kyung Jun Yeu, Jeong Yeong Park, Jung Eun Choi, Su Hwan Kang, Young Kyung Bae, Soo Jung Lee
Journal: Cancer Research (2015)

Abstract Background: Skin sparing mastectomy (SSM) has been conducted in breast cancer patient because of both oncologic safety and cosmetic satisfaction. Preservation of nipple-areolar complex (NAC) is helpful to keep more natural breast shape, but, can cause anxiety about local recurrence. This study reviewed long term follow-up result of SSM and nipple-areolar skin sparing mastectomy (NASSM), retrospectively. Patients and methods: This study included 272 primary breast cancer patients who received SSM (94 patients) or NASSM (178 patients) except bilateral breast cancer from September 1996 to December 2008. Frozen section was conducted for analysis of NAC resection margin status. In case of positive resection margin, NAC was sacrificed. Local recurrence and overall survival of SSM and NASSM group was analyzed. Results: The mean follow-up was 94.9 months. 81 NAC resection margins (29.8%) were invaded by tumor cells. The positive resection margin of NAC was associated with presence of ductal carcinoma in situ (p=0.005), especially extensive intraductal component (p=0.005) and invasive carcinoma with multiplicity (p=0.048). The patients in NASSM group tended to have more worse disease free survival than those in SSM group (75.3% vs 86.2%, P=0.087). But, in analysis of only local recurrence including NAC, there were 25 cases (14.0%, 7 in skin flap and 18 in NAC) of local recurrence in NASSM group and 8 (8.5%) in SSM group. Local recurrence free survival of the NASSM group was 86.0% and that of the SSM group was 91.5% (P=0.278). Distant recurrence after surgical treatment for local relapse occurred in only one SSM case. There was no significant difference for the overall survival between NASSM and SSM group (97.8% vs 96.8%, p=0.556). Conclusion: In this study, result of long term follow up showed that patients in NASSM group tend to have more local recurrence than patients in SSM group, even if there is no statistically significance. However, surgically well-controlled local recurrence of skin flap and/or NAC did not affect on overall survival. NASSM is alternative method for SSM with oncological safety and better cosmetic outcome. Citation Format: Kyung Jun Yeu, Jeong Yeong Park, Jung Eun Choi, Su Hwan Kang, Young Kyung Bae, Soo Jung Lee. The oncologic safety of nipple-areolar complex skin sparing mastectomy compared with skin sparing mastectomy: 8 years follow up results [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P2-13-23.
Patients will consult doctors through a TV screen in 2020
Authors: Rhona MacDonald
Journal: BMJ (2000)

Patients might have their own “health biography” held in an encrypted form on the internet by the year 2020, a new report from the healthcare panel of the Foresight programme says.

The programme, which was set up by the UK Department of Trade and Industry to look at and prepare for the future, has 13 independent panels and brings together business, science, the voluntary sector, and the government.

The healthcare panel has suggested in a new report that, by 2020, patients may be able to consult a “virtual cyber physician” who can be accessed through …
Krusen's Handbook of Physical Medicine and Rehabilitation.
Authors: [edited by] Frederic J. Kottke, Justus F. Lehmann.
Journal: Annals of Internal Medicine (1991)

Evaluation of the Patient: Measurement of Musculoskeletal Function: Electrodiagnosis: Gait Analysis. Diagnosis and Management : Speech and Language Disorders: Psychological Assessment and Management: Psychosocial Diagnosis and Social Services: Vocational Assessment and Management: Prevocation Evaluation: The Epidemiology of Disability as Related to Rehabilitation Medicine: The Neurophysiology of Motor Function: Health Accounting: Functional Assessment of the Long-Term Patient: Diathermy and Superficial Heat, Laser and Cold Therapy: Ultraviolet Therapy: Electrotherapy: Acupuncture in Physiatry: Massage: Therapeutic Exerciseto Maintain Mobility: Therapeutic Exercise to Develop Neuromuscular Coordination: Therapeutic Exercise to Develop Strength and Endurance: Bed Positioning: Transfers: Method, Equipment and Preparation: Wheelchair Prescription: Training for Functional Independence: Training in Homemaking Activities: Upper Extremity Orthotics: Spinal Orthoses: Lower Extremity Orthotics: Prescription Writing in Physical Medicine and Rehabilitation: Rehabilitation of Patients with Complete Stroke: Rehabilitation in Arthritis and Allied Conditions: Traumatic and Congenital Lesions of the Spinal Cord: Aftercare of Fractures: Rehabilitation Management of Diseases of the Motor Unit: Rehabilitation for Swallowing Impairment: Degenerative Diseases of the Central Nervous System: Spine. Disorders and Deformities: Management of Neurogenic Dysfunction of the Bladder and Bowel: Rehabilitation of Children with Brain Damage: Rehabilitation of Respiratory Dysfunction: Rehabilitationof the Patient with Heart Disease: Management of Vascular Disease: Reconstructive Surgery of the Extremities: Diagnosis An
Abstract 1755: Metabolic Changes in Plasma Revealed by Planned Heart Attacks
Authors: Gregory D Lewis, Ru Wei, Marc S Sabatine, Aarti Asnani, Maryann E Martinovic, Laurie A Farrell, Emerson Liu, Igor F Palacios, Steven A Carr, Vamsi K Mootha, Michael A Fifer, Robert E Gerszten
Journal: Circulation (2007)

Background: An emerging set of metabolic profiling tools enable the monitoring of hundreds of analytes in biological samples, and have raised the possibility of establishing metabolic signatures of...
Abstract P451: Correlates of Prehospital Delay in ACS Patients in a Medically Underserved Appalachian Community
Authors: Masroor A Abro, Wissam Gharib, Bradford Warden, Abnash Jain, Kristen Bell, Jeremy Waters, Christopher Arena, Dustin Long, Walker S Poston, Stanley B Schmidt
Journal: Circulation (2014)

Introduction: We evaluated correlates of seeking treatment among ACS patients in a rural, medically underserved community. This study is unique because patient data came from medical records and physician-administered structured interviews and it is the first to evaluate correlates of treatment delay in a rural and medically underserved patients. Methods: A physician-administered structured interview was administered to 170 consecutive ACS patients. Patients were recruited from June 2010-December 2012. Inclusion criteria were: 1) chest pain or discomfort with onset outside hospital; and 2) fulfilling the criteria for ACS (i.e., chest pain or discomfort, changes on the ECG and/or an increase in at least one biochemical marker. The structured interview was composed of standardized questions with pre-defined answer categories covering 10 domains: 1) Patient demographics; 2) Presenting symptoms (e.g., first symptoms and type of symptom; symptom intensity/progression, symptom description and knowledge, etc.); 3) Responses to symptoms (e.g., informed someone, summoned help); 4) Symptom context (e.g., activity at time of AMI, place it occurred); 5) factors associated with decision to seek help (e.g., distance to hospital, transportation available, how transported, money, etc.); 6) Psychological/Personality factors (e.g., current depression, anxiety, denial patterns, personality types A or B); 8) Technology use (e.g., time spent watching TV or using smart devices/internet, etc.); 9) Prior cardiac history and risk factors (e.g., history of hypertension, diabetes, obesity, hyperlipidemia, medications, ER laboratory data); and 11) Post admission clinical course (e.g., ECG, arrhythmias, lytic therapy, CCU days, PCI, CABG, TIMI score , complications). Late presentation was defined as greater than 90 minutes for STEMI patients and greater than 180 minutes for NSTEMI patients. Results: Among STEMI patients (n=98), only marital status (currently married vs. not married; OR=0.3; CI=0.1-0.9) and concerns about money (OR =26.3; CI = 1.2-500.0) were significantly associated with late presentation for treatment. For NSTEMI patients (n=73), several presenting symptom variables were associated with seeking treatment early including whether they experienced pain radiating to the arms (OR=0.1; CI=0.0-0.59), describing their chest pain as heavy (OR=0.04; CI=0.0-0.4), and reporting that nitroglycerin relieved chest pain (OR=0.2; CI = 0.1-0.9). One post-admission variable (whether they had Acute PCI post-MI; OR=0.1; CI=0.0-0.7) also was associated with late treatment. Conclusions: Being unmarried or having concerns about money were associated with delays in treatment for STEMI patients, while mostly symptom-related variables were associated with treatment delays among NSTEMI patients in this cohort of low-income, medically underserved patients.
Sharing Patient Health Data
Authors: Tracy Hampton
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
657. Immune Responses to Transgene Expression Targeted to Keratinocytes
Authors: Soosan Ghazizadeh, Lorne B. Taichman, Richard S. Kalish
Journal: Molecular Therapy (2004)

Transgene-specific immune responses impose a major hurdle to effective implementation of clinical gene therapy, especially in situations where neoantigen is expressed. Previously, in our studies of cutaneous gene therapy, we showed that neoantigen expression leads to a potent immune response and rejection of the retroviral-transduced epidermal cells in normal mice. As cutaneous gene therapy will often require prolonged transgene expression, we seek a strategy to avoid this host response. One such strategy utilizes the fact that antigen presentation by non-professional antigen presenting cells (APCs), including keratinocytes, may result in T cell unresponsiveness. To explore this concept, the dorsal skin of immunocompetent mice was transduced in vivo with 2 × 107 transducing units of either standard retroviral vector encoding GFP or retroviral vectors in which GFP expression is targeted to the suprabasal layers of epidermis. Initial GFP expression in both groups of animals was confirmed at 1-week post transduction by fluorescent stereo microscopy. Examination at 3 weeks however, indicated loss of GFP expression in both groups of transduced mice coinciding with the generation of significant levels of anti-GFP antibody. Although expression was directed to epidermal keratinocytes, the acute loss of transduced cells may have resulted from uptake of GFP entrapped in the viral particle by professional APCs, which are abundant in skin. This possibility is currently being examined with an ex vivo model of cutaneous gene transfer in which transgene expression will be confined solely to keratinocytes and transplanted to immunocompetent mice.
Abstract P388: Novel Metabolic Markers for the Risk of Carotid Plaque Progression in American Indians
Authors: Yun Zhu, An Qiang, Lyle G Best, Elisa T Lee, Barbara V Howard, Richard B Devereux, Mary J Roman, Jinying Zhao
Journal: Circulation (2015)

Background: Carotid atherosclerotic plaque and its progression significantly predict cardiovascular events. Traditional clinical factors have limited value in early risk prediction. Metabolomics is an emerging technology that can accurately quantify hundreds to thousands of small metabolites in biofluids, thus providing a powerful tool for early biomarker discovery. Previous studies were largely cross-sectional with a focus on the European population, results of which may not be generalized to other ethnic groups. In addition, causality cannot be resolved in cross-sectional analysis. Objective: To prospectively identify novel metabolic markers predictive of carotid plaque onset and progression in American Indians in the Strong Heart Study (SHS). Methods: This study includes 396 apparently healthy American Indians attending both clinical exams in 2001-2003 and 2006-2009 (average 5.5 years of follow-up). All participants had normal fasting glucose and were free of overt CVD at baseline. Plaque progression was defined as having a higher plaque score at the end of follow-up compared to baseline. Fasting plasma metabolites were detected using untargeted LC-MS. A total of 1,364 matching metabolites that passed stringent QC were included in the current analysis. The prospective association of plaque progression with each metabolite was examined using Cox proportional hazards model, adjusting for sex, site, age, BMI, eGFR, lipids, blood pressure, smoking and alcohol drinking at baseline. The combined metabolic effect was examined using a weighted multi-marker metabolites score comprising of all significant metabolites. Incremental value of novel metabolites over traditional risk factors for risk prediction was tested using the net reclassification improvement index (NRI). Multiple testing was corrected using the q-value method (q&lt; 0.05 was considered statistical significance). Results: Of all 396 participants, 100 developed new plaque or progressed to a high order of atherosclerosis during follow-up. Five metabolites including PC (6:2/14:2) (HR 1.56[1.23-1.96]), proscillaridin A (HR 1.68 [1.27-2.21]), 8e-heptadecenedioic acid (HR 1.56 [1.22-1.98]), flavone (HR 1.69 [1.27-2.26]), and n-palmitoyl methionine (HR 1.72 [1.28-2.32]), significantly increase, whereas one metabolite, PC (18:0/18:1) (HR 0.62 [0.52-0.73]), significantly decreases the risk of plaque progression. A multi-marker score comprising of all six metabolites significantly improves risk prediction beyond traditional risk factors (NRI=0.22, P=1.23x10-5). Conclusions: Altered levels of fasting plasma metabolites significantly predict the risk of plaque onset and progression over and above conventional risk factors. The newly detected metabolites may unravel novel metabolic pathways underlying CVD pathogenesis and could be used as new markers for risk prediction and stratification.
62. Ras Signaling as a Marker for Application of Oncolytic Herpes Mutant Against Lymphoma
Authors: Kenji Nakano, Ryutaro Asano, Kohei Tsumoto, William F. Goin, Izumi Kumagai, Justus B. Cohen, Joseph C. Glorioso
Journal: Molecular Therapy (2004)

Herpes simplex virus (HSV) enters cells via initial binding of envelope glycoproteins C and B to cell-surface glycosaminoglycans (GAGs) and subsequent membrane fusion involving gD, gB and gH/gL. Current insights suggest that the fusion process is initiated by interaction of gD with a cognate cellular receptor, such as the widely-distributed cell adhesion molecule nectin-1/CD115. To re-direct the tropism of HSV-1, we have generated a soluble adapter protein comprising the gD-binding variable (V) domain of nectin-1 fused to a single-chain antibody (V528LH) recognizing the EGF receptor. The adapter molecule enabled HSV-1 entry into naturally non-permissive CHO cells expressing the EGF receptor, but not into CHO cells lacking the receptor. Furthermore, entry was not observed when the antibody portion of the adapter was replaced with an antibody of different specificity. The degree of P-V528LH-adapter-mediated entry increased with the viral dose, reaching approximately 65% infected cells at a multiplicity of 3. Entry depended on viral gD and the availability of cellular GAGs. Although the adapter molecule did not block nectin-1-mediated cellular susceptibility to HSV-1, preconditioning of nectin-1-bearing cells with competitive inhibitors of the normal nectin-1/gD interaction reduced nectin-1-mediated entry without limiting adapter-mediated entry via the EGF receptor. These results indicate that an adapter molecule along with nectin-1 blocking agents can re-direct HSV infection.
SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling
Authors: Juan L. García-Rodríguez, Lucía Barbier-Torres, Sara Fernández-Álvarez, Virginia Gutiérrez-de Juan, María J. Monte, Emina Halilbasic, Daniel Herranz, Luis Álvarez, Patricia Aspichueta, Jose J.G. Marín, Michael Trauner, Jose M. Mato, Manuel Serrano, Naiara Beraza, María Luz Martínez-Chantar
Journal: Hepatology (2013)

Sirtuin1 (SIRT1) regulates central metabolic functions such as lipogenesis, protein synthesis, gluconeogenesis, and bile acid (BA) homeostasis through deacetylation. Here we describe that SIRT1 tightly controls the regenerative response of the liver. We performed partial hepatectomy (PH) to transgenic mice that overexpress SIRT1 (SIRT). SIRT mice showed increased mortality, impaired hepatocyte proliferation, BA accumulation, and profuse liver injury after surgery. The damaging phenotype in SIRT mice correlated with impaired farnesoid X receptor (FXR) activity due to persistent deacetylation and lower protein expression that led to decreased FXR-target gene expression; small heterodimer partner (SHP), bile salt export pump (BSEP), and increased Cyp7A1. Next, we show that 24-norUrsodeoxycholic acid (NorUDCA) attenuates SIRT protein expression, increases the acetylation of FXR and neighboring histones, restores trimethylation of H3K4 and H3K9, and increases miR34a expression, thus reestablishing BA homeostasis. Consequently, NorUDCA restored liver regeneration in SIRT mice, which showed increased survival and hepatocyte proliferation. Furthermore, a leucine-enriched diet restored mammalian target of rapamycin (mTOR) activation, acetylation of FXR and histones, leading to an overall lower BA production through SHP-inhibition of Cyp7A1 and higher transport (BSEP) and detoxification (Sult2a1) leading to an improved liver regeneration. Finally, we found that human hepatocellular carcinoma (HCC) samples have increased presence of SIRT1, which correlated with the absence of FXR, suggesting its oncogenic potential. Conclusion : We define SIRT1 as a key regulator of the regenerative response in the liver through posttranscriptional modifications that regulate the activity of FXR, histones, and mTOR. Moreover, our data suggest that SIRT1 contributes to liver tumorigenesis through dysregulation of BA homeostasis by persistent FXR deacetylation. (Hepatology 2014;59:1972–1983)
Subclonal diversification of primary breast cancer revealed by multiregion sequencing
Authors: Lucy R Yates, Moritz Gerstung, Stian Knappskog, Christine Desmedt, Gunes Gundem, Peter Van Loo, Turid Aas, Ludmil B Alexandrov, Denis Larsimont, Helen Davies, Yilong Li, Young Seok Ju, Manasa Ramakrishna, Hans Kristian Haugland, Peer Kaare Lilleng, Serena Nik-Zainal, Stuart McLaren, Adam Butler, Sancha Martin, Dominic Glodzik, Andrew Menzies, Keiran Raine, Jonathan Hinton, David Jones, Laura J Mudie, Bing Jiang, Delphine Vincent, April Greene-Colozzi, Pierre-Yves Adnet, Aquila Fatima, Marion Maetens, Michail Ignatiadis, Michael R Stratton, Christos Sotiriou, Andrea L Richardson, Per Eystein Lønning, David C Wedge, Peter J Campbell
Journal: Nature Medicine (2015)
Ambient ozone pollution as a risk factor for skin disorders
Authors: F. Xu, S. Yan, M. Wu, F. Li, X. Xu, W. Song, J. Zhao, J. Xu, H. Kan
Journal: British Journal of Dermatology (2011)

Journal Article Ambient ozone pollution as a risk factor for skin disorders Get access F. Xu, F. Xu Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China Search for other works by this author on: Oxford Academic Google Scholar S. Yan, S. Yan Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China Search for other works by this author on: Oxford Academic Google Scholar M. Wu, M. Wu School of Public Health, Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China Search for other works by this author on: Oxford Academic Google Scholar F. Li, F. Li Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China Search for other works by this author on: Oxford Academic Google Scholar X. Xu, X. Xu College of Public Health and Health Professions, University of Florida, Gainesville, FL, U.S.A. E‐mail: haidongkan@gmail.com Search for other works by this author on: Oxford Academic Google Scholar W. Song, W. Song School of Public Health, Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China Search for other works by this author on: Oxford Academic Google Scholar J. Zhao, J. Zhao School of Public Health, Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China Search for other works by this author on: Oxford Academic Google Scholar J. Xu, J. Xu Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China Haidong Kan or J. Xu. E‐mail: j.frank@mumc.nl or xjhhs@medmail.com.cn Search for other works by this author on: Oxford Academic Google Scholar H. Kan H. Kan School of Public Health, Key Laboratory of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China Haidong Kan or J. Xu. E‐mail: j.frank@mumc.nl or xjhhs@medmail.com.cn Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 165, Issue 1, 1 July 2011, Pages 224–225, https://doi.org/10.1111/j.1365-2133.2011.10349.x Published: 01 July 2011