tbuckley/cabot-search huggingface dataset:
Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features
Authors: Davor Lessel, Bruno Vaz, Swagata Halder, Paul J Lockhart, Ivana Marinovic-Terzic, Jaime Lopez-Mosqueda, Melanie Philipp, Joe C H Sim, Katherine R Smith, Judith Oehler, Elisa Cabrera, Raimundo Freire, Kate Pope, Amsha Nahid, Fiona Norris, Richard J Leventer, Martin B Delatycki, Gotthold Barbi, Simon von Ameln, Josef Högel, Marina Degoricija, Regina Fertig, Martin D Burkhalter, Kay Hofmann, Holger Thiele, Janine Altmüller, Gudrun Nürnberg, Peter Nürnberg, Melanie Bahlo, George M Martin, Cora M Aalfs, Junko Oshima, Janos Terzic, David J Amor, Ivan Dikic, Kristijan Ramadan, Christian Kubisch
Journal: Nature Genetics (2014)
Mechanism of action of Escherichia coli heat stable enterotoxin in a human colonic cell line.
Authors: P A Huott, W Liu, J A McRoberts, R A Giannella, K Dharmsathaphorn
Journal: Journal of Clinical Investigation (1988)

Escherichia coli heat stable enterotoxin (STa) caused Cl- secretion across T84 cell monolayers in a dose-dependent manner only when applied to the apical membrane surface and not when applied to the basolateral surface. Measurement of cAMP, cGMP, and free cytosolic Ca2+ in response to STa suggested that cGMP alone mediated the Cl- secretory response. Studies utilizing blockers of the Na+,K+-ATPase pump, a Na+,K+,Cl- cotransport system, a K+ channel, and a Cl- channel suggest that all of them participate in the Cl- secretory process induced by STa. The results suggest that the Cl- secretory response induced by STa is mediated by cGMP after the enterotoxin binds to its receptor on the apical membrane. The enterotoxin, by increasing cGMP, opens a K+ channel on the basolateral membrane as well as a Cl- channel on the apical membrane. The activation of these ion exit mechanisms, together with activations of the Na+,K+,Cl- cotransporter and the Na+,K+-ATPase pump drives Cl- exit through the Cl- channel on the apical membrane.
Older patients are eligible for trial of lithium and valproate
Authors: J. M Rendell
Journal: BMJ (2003)

EDITOR—Shulman et al report an increase in the prescription of valproate for elderly patients with bipolar disorder in Canada (and corresponding decrease in prescription of lithium).1 A similar pattern has been observed in the United States over the past decade or so.2 As the authors note, this change has occurred despite the …
Bowenoid papulosis in three-year-old girl
Authors: Charles Halasz, David Silvers, Christopher P. Crum
Journal: Journal of the American Academy of Dermatology (1986)

A three-year-old girl presented with perianal bowenoid papulosis that was presumed to be induced by sexual contact. The lesion was treated by biopsy only and regressed over 8 months without further therapy. The importance of this case with respect to the viral cause, venereal transmission, and spontaneous regression is discussed. This case represents the youngest known patient with bowenoid papulosis reported to date. A three-year-old girl presented with perianal bowenoid papulosis that was presumed to be induced by sexual contact. The lesion was treated by biopsy only and regressed over 8 months without further therapy. The importance of this case with respect to the viral cause, venereal transmission, and spontaneous regression is discussed. This case represents the youngest known patient with bowenoid papulosis reported to date.
Cholecystectomy protects against extrahepatic bile duct cancer: Is this a result of the removal of gallstones?
Authors: David T. Walden, Roger D. Soloway, Roger S. Crowther
Journal: Hepatology (1994)

The aetiology of cancer of the extrahepatic bile duct is unknown. Gallstones have been proposed to be a risk factor on the basis of ecological and epidemiological evidence. As gallstones are formed in the gallbladder, the occurrence of extrahepatic bileduct cancer in patients after cholecystectomy is of interest. All patients (62 734) who had had a cholecystectomy during 1965-1983 within the Uppsala Health Care Region, Sweden, were followed up to the end of 1987. Excluding the first year of follow-up, 23 cancers of the extrahepatic bileduct occurred vs 26.3 expected for a standardised incidence ratio (SIR) of 0.88 (95% confidence interval [CI] 0.56-1.31). Ten years or more after operation there was a greater reduction of risk (SIR=0.27; 95% CI 0.06-0.80). Similar patterns were observed for men and women, and among patients who had undergone cholecystectomy only compared with those who had had their common bileducts explored. To assess surveillance bias the incidence of primary liver cancer was also analysed: SIR=1.15; 95% CI 0.91-1.44 overall, and 10 years or more after cholecystectomy SIR=0.98; 95% CI 0.66-1.40. This study shows a reduced risk of extrahepatic bileduct cancer 10 or more years after cholecystectomy, indicating that gallstones may be a cause of cancer.
Book Review Boundaries of Privacy: Dialectics of Disclosure (SUNY Series in Communication Studies.) By Sandra Petronio. 268 pp. Albany, State University of New York Press, 2002. $81.50 (cloth); $27.95 (paper). 0-7914-5515-7 (cloth); 0-7914-5516-5 (paper).
Authors: Paul S. Appelbaum
Journal: New England Journal of Medicine (2003)
Impaired Humoral Immunity in Treated Hodgkin's Disease
Authors: Sigmund A. Weitzman, Alan C. Aisenberg, George R. Siber, David H. Smith
Journal: New England Journal of Medicine (1977)

To define the contribution of aggressive lymphoma treatment to the risk of post-splenectomy septicemia, we investigated the humoral immunity of 44 patients with Hodgkin's disease. Specific antibody against Haemophilus influenzae Type b was significantly reduced (mean, 147 ng per milliliter, P less than 0.01) in patients receiving combined treatment (radiotherapy and chemotherapy), whereas single treatment reduced titers marginally (chemotherapy) or not at all (radiotherapy). Untreated patients had normal values (396 ng per milliliter), and splenectomy was without effect. In some patients who received combined treatment, titers were reduced to levels seen in infants. IgM levels were likewise normal in untreated patients. Chemotherapy, however, significantly reduced IgM levels (P less than 0.025), an effect potentiated by prior splenectomy. IgG, IgA, alternate-pathway activity, C3, C4 and CH50 were all normal or elevated. Aggressive treatment with chemotherapy and radiation impairs humoral defense against encapsulated micro-organisms, and thus magnifies the risk of post-splenectomy septicemia in patients with Hodgkin's disease.
Attempts to control clinical activities
Authors: A B Clymo, A G Jacobs
Journal: BMJ (1986)

women with testosterone values exceeding 3 nmol/l (0-87 ttg/ml), which is consistent with hyper- androgenism.Although, as the authors suggest, "hidradenitis suppurativa falls into the same category as acne vulgaris and idiopathic hirsutism as an example of primary cutaneous virilism," it is of interest that dehydroepiandrosterone sulphate values are not raised in patients with hidradenitis suppurativa, in contrast to patients with the other diseases.This suggests that hidradenitis suppurativa may have a distinct hormonal cause.
Abstract 2208: Optimal Dose of Clopidogrel for Platelet Inhibition in Children: Primary Results of the PICOLO Trial
Authors: Jennifer S Li, Katherine Y Berezny, Eric Yow, Paula M Bokesch, Matsato Takahashi, Thomas P Graham, Stephen P Sanders, Lisa K Jennings
Journal: Circulation (2006)

Background: Children with certain types of congenital heart disease (CHD) are at increased risk for thrombotic complications. Clopidogrel is an ADP platelet antagonist widely used in adults at a do...
Pheochromocytoma Associated with Cerebellar Hemangioblastoma
Authors: R. Cecil Chapman, Rodrigo Diaz-Perez
Journal: JAMA (1962)

It is well known that pheochromocytoma is much more likely to occur in persons having multiple neurofibromatosis than in otherwise normal persons. In addition, a number of cases of the simultaneous occurrence of pheochromocytoma and von Hippel-Lindau's disease have been described in recent years. The authors report 2 cases of the latter association of lesions in a mother and son, both of whom had cerebellar hemangioblastoma and bilateral pheochromocytomas. Von Hippel-Lindau's disease and multiple neurofibromatosis are commonly considered to be related dysplasias of those tissues which arise from the neurectoderm. Since the adrenal medulla is also of neurectodermal origin, it is not surprising that these disorders are associated with a high incidence of pheochromocytoma.
Web-based information on intraoperative neuromonitoring in thyroid surgery
Authors: Cesare Carlo Ferrari, Sebastiano Spampatti, Andrea Leotta, Stefano Rausei, Francesca Rovera, Luigi Boni, Davide Inversini, Giulio Carcano, Gianlorenzo Dionigi, Renzo Dionigi
Journal: International Journal of Surgery (2013)
THE LEFT SUBCLAVIAN ARTERY AS PRIMARY ACCESS SITE FOR TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Peter C. Kievit, Michel W. Verkroost, Helmut R. Gehlmann, Kees van der Wulp, Luc Noyez, Henri A. van Swieten, Harry Suryapranata, Menko–Jan de Boer
Journal: Journal of the American College of Cardiology (2013)
Academic Medical Centers and Nursing Home Affiliations
Authors: David Hamerman
Journal: Annals of Internal Medicine (1994)

Letters1 September 1994Academic Medical Centers and Nursing Home AffiliationsDavid Hamerman, MDDavid Hamerman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-5-199409010-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Besdine and colleagues [1] in their thoughtful editorial highlighted a need for physicians' services from the perspective of the nursing homes and their residents. I would like to emphasize the need for academic medical centers to affiliate with nursing homes, in addition to sites for “step-down” care mentioned by the authors. They have provided a unique site for collaboration programs for training, education, and research [2] through initiatives undertaken by the National Institute on Aging [3], the Robert Wood Johnson Foundation, and the Veterans Affairs Administration. A recent survey of 121 medical schools indicated that 90% had ...References1. Besdine RW, Rubenstein LZ, Cassel C. Nursing home residents need physicians' services (Editorial). Ann Intern Med. 1994; 120:616-8. Google Scholar2. Hamerman D. Evolution of affiliations between academic medical centers and nursing homes. Journal of Medical Direction. 1992; Jan:37-40. Google Scholar3. Butler RW. The teaching nursing home. JAMA. 1981; 245:1435-7. Google Scholar4. Schneider EL, Ory M, Aung ML. Teaching nursing homes revisited. Survey of affiliations between American medical schools and long term care facilities. JAMA. 1987; 257:2771-5. Google Scholar5. Aronson MK, Hamerman D, Wolfson L. Research with the old-old in the context of a teaching nursing home. Einstein Quarterly Journal of Biology and Medicine. 1988; 6:190-4. Google Scholar Author, Article, and Disclosure InformationAuthors: David Hamerman, MDAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1994Volume 121, Issue 5Page: 389KeywordsAgingHealth careMotivationNursing homes ePublished: 15 August 2000 Issue Published: 1 September 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cost of Treating Travelers' Diarrhea
Authors: Jorge Goldberg
Journal: Annals of Internal Medicine (1991)

Letters15 August 1991Cost of Treating Travelers' DiarrheaJorge Goldberg, MDJorge Goldberg, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-4-331_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:In their recent review of the treatment of travelers' diarrhea, Taylor and colleagues (1), did not address the issue of cost. The treatment of travelers to countries having a high prevalence of enterotoxigenicEscherichia coliis warranted. As mentioned in their article and previously reported (2), several effective regimens are available. Comparing the prices of the medications may be important when two regimens are similarly effective. The prices (in dollars) in Mexico City are: ciprofloxacin, 500 mg, $26; trimethoprim-sulfamethoxazole, $2; and loperamide (Imodium) and diphenoxylate (Lomotil), $1 to $2....References1. TaylorSanchezCandlerThorntonMcQueenEcheverria DJWSCP. Treatment of travelers' diarrhea:ciprofloxacin plus loperamide compared with ciprofloxacin alone. Ann Intern Med. 1991;114:731-4. LinkGoogle Scholar2. EricssonDuPontMathewsonWestJohnsonBitsura CHJMPJ. Treatment of traveler's diarrhea with sulfamethoxazole and trimethoprim and loperamide. JAMA. 1990;263:257-61. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: A.B.C. Hospital Mexico City Mexico PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 August 1991Volume 115, Issue 4Page: 331-331KeywordsDiarrheaEscherichia coli Issue Published: 15 August 1991 PDF downloadLoading ...
Abstract 2031: Effect of 2-Deoxyglucose on colorectal cancer cell lines
Authors: Pratik U. Muley, Alex Olinger, Hemachand Tummala
Journal: Cancer Research (2012)

Abstract Aerobic glycolysis (Warburg Effect) has long been regarded as a hallmark of many types of cancers. Colorectal cancer is known to exist in hypoxic conditions and hence, it is believed that most of the colorectal carcinoma tumors depend more on glycolysis than other tumors. A number of drugs have been developed in the past to target the up-regulated glycolytic pathway of the tumor cells, including 2-Deoxy-glucose (2DG). Being structurally similar to D-Glucose, it is utilized in the glycolytic pathway and is phosphorylated to 2DG-phosphate, which starts to accumulate in the cells. The accumulated 2DG-phosphate, inhibits key glycolysis enzymes - hexokinase and phospho-glucoisomerase leading to inhibition of glycolysis, and thus starving the cells of ATP. Although this has been regarded as the major mechanism of 2DG, various observations question this being the sole mechanism of action. To further investigate the molecular mechanism of 2DG, we studied its effect on colorectal carcinoma cell lines (GC3/Cl, SW620 and SW480) alone or in combination with 5-fluorouracil (5FU). We have observed that colorectal carcinoma cells are highly susceptible to 2DG compared to other cancer cells or non-cancerous cells and exert an additive effect in combination with 5FU. 2DG treatment arrested cell cycle at G1/G0 checkpoint and promoted apoptosis. The treatment of 2DG also resulted in a transient increase in the expression of p21. A reduced expression of other cell cycle proteins such as cyclin D1 and cyclin A was also observed following the 2DG treatment. Here, we provide evidence that in colorectal carcinoma cell lines, the 2DG causes a cell cycle arrest in addition to glycolysis inhibition and this additional activity may be responsible for an increased susceptibility of colorectal cancer cell lines to 2DG. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2031. doi:1538-7445.AM2012-2031
Hospitals Are Not Hotels
Authors: Stephanie Iantorno, Evan Fieldston
Journal: JAMA Pediatrics (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Atherosclerosis Reviews 23: Atherosclerosis: Its Pathogenesis and the Role of Cholesterol.
Authors: D. Leake
Journal: Cardiovascular Research (1992)

Journal Article Atherosclerosis Reviews 23: Atherosclerosis: Its Pathogenesis and the Role of Cholesterol. Get access David Leake David Leake Reading, United Kingdom Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 26, Issue 10, October 1992, Page 1007, https://doi.org/10.1093/cvr/26.10.1007a Published: 01 October 1992
Release of vasoactive intestinal peptide in the dumping syndrome.
Authors: G R Sagor, M G Bryant, M A Ghatei, R M Kirk, S R Bloom
Journal: BMJ (1981)

To determine the effect of gastric surgery on the plasma vasoactive intestinal peptide (VIP) concentration, 13 patients with gastrectomy and seven controls were given an oral hypertonic load (200 ml 50% glucose solution). Blood was taken at intervals during the test for measurement of VIP and blood glucose concentrations and packed cell volume. At the same time observations were made on the occurrence of dumping symptoms and a record kept of the pulse rate. VIP values in the patients with gastrectomy were significantly increased by glucose ingestion, while these did not alter in controls (p less than 0.001). There was a highly significant correlation between the rate of rise in plasma VIP concentration and the rates of rise in packed cell volume (r = 0.85; p less than 0.001) and blood glucose concentration (r = 0.76; p less than 0.01) in patients with gastrectomy. Changes in packed cell volume and blood glucose values and the occurrence of dumping symptoms during the test were significantly different when postoperative patients were compared with controls (p less than 0.001, p less than 0.005, and p less than 0.001 respectively). Furthermore, when the patients with gastrectomy were divided into those without symptoms and those with dumping after meals the latter group showed a significantly greater rise of VIP (p less than 0.05). Despite the increased plasma VIP concentrations observed during dumping, VIP cannot be taken as the sole factor in the pathogenesis of the dumping syndrome.
Gastric Polyps Followed 20 Years
Authors: Joseph T. Ferrucci
Journal: JAMA (1967)

Dr. Jack Wittenberg: This 82-year-old woman was admitted because of rectal bleeding. She had been seen intermittently in this hospital since 1946. At that time an upper gastrointestinal tract study was performed to evaluate epigastric pain (Fig 1). Her hematocrit reading at that time was normal. <h3>Discussion</h3> Dr. Laurence L. Robbins: Dr. Hanelin, do you have any comments? Dr. Joseph Hanelin: There appear to be multiple gastric polyps, especially in the lower half of the stomach. I think that these are benign. Malignancy is rather frequently associated with these lesions, although an entirely benign course is possible. Dr. Robbins: Do you think these patients should be kept under observation? Dr. Hanelin: In general, I think the initial approach is that of a local resection of the area of involvement, especially if there are symptoms or suspicious areas by x-ray or endoscopy. In any event, these patients should certainly be examined
GP88 Serum Level Is Increased in Breast Cancer Patients with Disease Progression.
Authors: G. Serrero, G. Serrero, K. Tkaczuk, B. Yue, S. Kamimura, N. Tait, M. Zhan, D. Ecklund
Journal: Cancer Research (2009)

Abstract GP88 (progranulin) is an 88-kDa glycoprotein autocrine growth factor that plays a critical role in breast tumorigenesis. GP88 is expressed in human BC tumors in a positive correlation with their tumorigenicity. In estrogen receptor positive (ER+) cells, GP88 expression is low and is stimulated by estradiol whereas in ER negative (ER-) cells, it is constitutively overexpressed. In ER+ cells, increased GP88 expression was found to be associated with resistance to anti-estrogen therapy. In Her-2 overexpressing breast tumors, increased GP88 expression was associated with Herceptin resistance. Inhibition of GP88 expression in human breast adenocarcinoma cells resulted in a drastic reduction of tumor incidence and tumor growth in nude mice. Immunohistochemical studies carried out with 206 paraffin-embedded human breast biopsies have shown that GP88 is expressed in invasive ductal carcinomas in correlation with expression of markers of poor prognosis whereas normal tissues and benign breast lesions were negative. Importantly, high GP88 expression in tissue biopsies was accompanied by decreased disease-free and overall survival. Since GP88 contains a signal peptide for secretion, we have shown that GP88 can be found in serum. An IRB approve blood sampling study of 189 patients (Race: Caucasian- 91, African American-92, Asian-6; median age- 51 with a range from 26 to 81) established at the University of Maryland demonstrated that GP88 was measurable in serum and that GP88 serum level was statistically elevated in breast cancer patients when compared to healthy individuals. Median level of GP88 was 40.7 ng/ml (range 6.4-80) in early stage (stage 1 –3) BC pts (p- value = 0.007) and 45.3 ng/ml (range 9.8 to 158.4) in stage 4 metastatic BC patients (p-value= 0.0007). Statistically significant increase in circulating GP88 level was found in early stages as well as in metastatic disease when compared to healthy individuals.Since we have shown that GP88 tissue expression was associated with increased disease recurrence, the present study was focused on examining whether GP88 serum level was also increased in disease progression and could be used to monitor disease recurrence. Our data show that patients with disease recurrence or progression presented a 5 to 10 fold increase in their GP88 serum levels.This study identifies GP88 as a measurable biomarker for recurrence or disease progression not only at the tissue but also at the serum level.This study is supported by grants from MIPS, the Avon Foundation and from the National Cancer Institute. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 6040.