THE NEPHROTIC PHASE: ITS FREQUENCY OF OCCURRENCE AND ITS DIFFERENTIAL DIAGNOSTIC VALUE IN DETERMINING THE NATURE OF THE RENAL LESION IN 120 PATIENTS WHO DIED OF RENAL FAILURE
Authors: W L BLOOM, D SEEGAL
Journal: Annals of Internal Medicine (1946)

Article1 July 1946THE NEPHROTIC PHASE: ITS FREQUENCY OF OCCURRENCE AND ITS DIFFERENTIAL DIAGNOSTIC VALUE IN DETERMINING THE NATURE OF THE RENAL LESION IN 120 PATIENTS WHO DIED OF RENAL FAILUREWALTER L. BLOOM, DAVID SEEGALWALTER L. BLOOMSearch for more papers by this author, DAVID SEEGALSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-1-15 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe term "nephrotic phase" is used to describe a syndrome occurring during the course of chronic glomerulonephritis and characterized by albuminuria, hypoproteinemia, hypercholesterolemia and edema. In general, these features have served as the criteria for diagnosis.1, 2 The degrees of hypoproteinemia, proteinuria, edema and lipemia necessary for the diagnosis have not been clearly defined.There is agreement over the occurrence of the nephrotic phase in particular types of renal diseases which terminate in renal failure. Baehr3noted that "every case of glomerulonephritis has a nephrotic element." Christian4agrees with this opinion. The rarity of the nephrotic phase in arteriolarnephrosclerosis...Bibliography1. LEITER L: Nephrosis, Medicine, 1931, x, 221-225. Google Scholar2. ATCHLEY DW: The nephroses, Textbook of Medicine, Cecil, 1943, 6th edit, W. B. Saunders Co., Philadelphia, 924-925. Google Scholar3. BAEHR G: Discussion of "Nephrosis with glomerulonephritis," (case report) Margaret Worwick. Presented at Scientific Proceedings of the Twenty-Eighth annual meeting of the American Association of Pathologists and Bacteriologists, Am. Jr. Path., 1928, iv, 632. Google Scholar4. 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P.: The plasma proteins in relation to blood hydration. VIII. Serum proteins in heart disease, Jr. Clin. Invest., 1932, xi, 103-112. PETERS J. P. BRUCKMAN F. S. EISENMAN A. J. HALD P. M. WAKEMAN A. M.: The plasma proteins in relation to blood hydration. IX. Serum proteins in the terminal stages of renal disease, Jr. Clin. Invest., 1932, xi, 113-122. CrossrefGoogle Scholar11. VAN SLYKESTILLMANMÖLLEREHRICHMCINTOSHLEITERMACKAYHANNONMOOREJOHNSTON DDEEWJFLEMRRNSC: Observations on the courses of different types of Bright's disease, and on the resultant changes in renal anatomy, Medicine, 1930, ix, 257-386. CrossrefGoogle Scholar12. BLOOR WR: The distribution of the lipoids ("fats") in human blood, Jr. Biol. Chem., 1916, xxv, 577-599. CrossrefGoogle Scholar13. DENIS W: Cholesterol in human blood under pathological conditions, Jr. Biol. Chem., 1917, xxix, 93-110. CrossrefGoogle Scholar14. PAGEKIRKVAN SLYKE IHEDD: Plasma lipids in essential hypertension, Jr. Clin. Invest., 1936, xv, 109-113. CrossrefGoogle Scholar15. STEINERDOMANSKI AB: Serum cholesterol and atherosclerosis in chronic glomerulonephritis, Am. Jr. Med. Sci., 1942, cciv, 79-84. CrossrefGoogle Scholar16. MANSFIELDMALLORYELLIS JSGKLB: The differential diagnosis of chronic Bright's disease, New England Jr. Med., 1943, ccxxix, 387-395. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication October 30, 1945.From the Research Service, First (Columbia) Division, Goldwater Memorial Hospital, Department of Hospitals, and the College of Physicians and Surgeons, Columbia University, New York City. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMASSIVE PROTEINURIA ASSOCIATED WITH VESICO-URETERAL REFLUXHistopathologie des nephrotischen Syndroms beim KindeThe General Appearance (Habitus)Uropoietic SystemThe nephrotic syndromeVergleichende pathologisch-anatomische und klinische Untersuchungen an 100 F�llen von diffuser GlomerulonephritisSTUDIES OF POSTSTREPTOCOCCAL NEPHRITIS AND OTHER GLOMERULAR DISEASES*†DAVID P. EARLE, M.D., F.A.C.P., ROBERT B. JENNINGS, M.D.THE NEPHROTIC SYNDROME IN ADULTS: A COMMON DISORDER WITH MANY CAUSES*ROBERT M. KARK, F.A.C.P., F.R.C.P. (Lond.), CONRAD L. PIRANI, M.D., VICTOR E. POLLAK, M.B., M.R.C.P.E., ROBERT C. MUEHRCKE, M.D., JOHN D. BLAINEY, M.D., M.R.C.P.Polycyclic nephrotic syndromeNatural history of glomerulonephritisGlomerular nephritis and lipid nephrosis: Identities and mechanismsGlomerulonephritisThe nephrotic syndromeThe Nephrotic Syndrome in ChildrenThe Nephrotic Syndrome 1 July 1946Volume 25, Issue 1Page: 15-21KeywordsEdemaGlomerulonephritisHyperlipidemiaHypoproteinemiaLesionsProteinuriaRenal diseasesRenal failureSurgeons ePublished: 1 December 2008 Issue Published: 1 July 1946 PDF downloadLoading ...