tbuckley/cabot-search huggingface dataset:
Pilot Study of Accelerated Hyperfractionated Thoracic Radiation Therapy Plus Concomitant Etoposide and Cisplatin Chemotherapy in Patients With Unresectable Stage III Non-Small-Cell Carcinoma of the Lung
Authors: E. G. Shaw, W. L. McGinnis, J. R. Jett, J. Q. Su, A. R. Frank, J. A. Mailliard, R. E. Engel, M. Wiesenfeld, K. M. Rowland
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Pilot Study of Accelerated Hyperfractionated Thoracic Radiation Therapy Plus Concomitant Etoposide and Cisplatin Chemotherapy in Patients With Unresectable Stage III Non-Small-Cell Carcinoma of the Lung Get access Edward G. Shaw, Edward G. Shaw Division of Radiation Oncology, Mayo Clinic and Mayo FoundationRochester, Minn Correspondence to: Edward G. Shaw, M.D., Division of Radiation Oncology, Desk R, Charlton Bldg., Mayo Clinic, 200 First St., SW, Rochester, MN 55905. Search for other works by this author on: Oxford Academic PubMed Google Scholar William L. McGinnis, William L. McGinnis Methodist Medical PlazaDes Moines, Iowa Search for other works by this author on: Oxford Academic PubMed Google Scholar James R. Jett, James R. Jett Division of Medical Oncology, Mayo Clinic and Mayo FoundationRochester, Minn Search for other works by this author on: Oxford Academic PubMed Google Scholar John Q. Su, John Q. Su Cancer Statistics Unit), Mayo Clinic and Mayo FoundationRochester, Minn Search for other works by this author on: Oxford Academic PubMed Google Scholar Albert R. Frank, Albert R. Frank Nebraska Oncology Group—Creighton University, University of Nebraska Medical Center and AssociatesOmaha Search for other works by this author on: Oxford Academic PubMed Google Scholar James A. Mailliard, James A. Mailliard Nebraska Oncology Group—Creighton University, University of Nebraska Medical Center and AssociatesOmaha Search for other works by this author on: Oxford Academic PubMed Google Scholar Roland E. Engel, Roland E. Engel Radiation Oncology, The St. Cloud HospitalSt. Cloud, Minn Search for other works by this author on: Oxford Academic PubMed Google Scholar Martin Wiesenfeld, Martin Wiesenfeld Cedar Rapids Oncology Project, Community Clinical Oncology Program (CCOP)Cedar Rapids, Iowa Search for other works by this author on: Oxford Academic PubMed Google Scholar Kendrith M. Rowland, Jr. Kendrith M. Rowland, Jr. Carle Cancer CenterCCOP, Urbana, III Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 4, 17 February 1993, Pages 321–323, https://doi.org/10.1093/jnci/85.4.321 Published: 17 February 1993 Article history Received: 30 July 1992 Revision received: 08 December 1992 Accepted: 09 December 1992 Published: 17 February 1993
Retinal Rod Photoreceptor–Specific Gene Mutation Perturbs Cone Pathway Development
Authors: Eyal Banin, Artur V. Cideciyan, Tomás S. Alemán, Robert M. Petters, Fulton Wong, Ann H. Milam, Samuel G. Jacobson
Journal: Neuron (1999)

Rod-specific photoreceptor dystrophies are complicated by the delayed death of genetically normal neighboring cones. In transgenic (Tg) swine with a rod-specific (rhodopsin) gene mutation, cone photoreceptor physiology was normal for months but later declined, consistent with delayed cone cell death. Surprisingly, cone postreceptoral function was markedly abnormal when cone photoreceptor physiology was still normal. The defect was localized to hyperpolarizing cells postsynaptic to the middle wavelength-sensitive cones. Recordings throughout postnatal development indicated a failure of cone circuitry maturation, a novel mechanism of secondary cone abnormality in rod dystrophy. The results have implications for therapy for human retinal dystrophies and raise the possibility that rod afferent activity plays a role in the postnatal maturation of cone retinal circuitry.
THE PRODUCTION OF KIDNEY ANTIBODIES BY INJECTION OF HOMOLOGOUS KIDNEY PLUS BACTERIAL TOXINS
Authors: Francis F. Schwentker, Frank C. Comploier
Journal: The Journal of Experimental Medicine (1939)

Rabbits injected with emulsions of homologous kidney to which staphylcoccus or streptococcus toxins had been added produced complement fixing antibodies which reacted with both rabbit kidney and brain. By absorption tests it was demonstrated that the sera contained at least two antibodies, one specific for kidney, the other non-specific. Similar kidney antibodies were found in the blood of a majority of patients with scarlet fever but in only a few normal persons. The possibility that a similar or related antibody may be concerned in the etiology of scarlatinal nephritis is discussed.
Similar predictive value of bone turnover using first- and second-generation immunometric PTH assays in pediatric patients treated with peritoneal dialysis
Authors: Isidro B. Salusky, William G. Goodman, Beatriz D. Kuizon, Jeffrey R. Lavigne, Richard J. Zahranik, Barbara Gales, He-Jing Wang, Robert M. Elashoff, Harald Jüppner
Journal: Kidney International (2003)
Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus.
Authors: G W Cline, I Magnusson, D L Rothman, K F Petersen, D Laurent, G I Shulman
Journal: Journal of Clinical Investigation (1997)

To determine the mechanism of impaired insulin-stimulated muscle glycogen metabolism in patients with poorly controlled insulin-dependent diabetes mellitus (IDDM), we used 13C-NMR spectroscopy to monitor the peak intensity of the C1 resonance of the glucosyl units in muscle glycogen during a 6-h hyperglycemic-hyperinsulinemic clamp using [1-(13)C]glucose-enriched infusate followed by nonenriched glucose. Under similar steady state (t = 3-6 h) plasma glucose (approximately 9.0 mM) and insulin concentrations (approximately 400 pM), nonoxidative glucose metabolism was significantly less in the IDDM subjects compared with age-weight-matched control subjects (37+/-6 vs. 73+/-11 micromol/kg of body wt per minute, P < 0.05), which could be attributed to an approximately 45% reduction in the net rate of muscle glycogen synthesis in the IDDM subjects compared with the control subjects (108+/-16 vs. 195+/-6 micromol/liter of muscle per minute, P < 0.001). Muscle glycogen turnover in the IDDM subjects was significantly less than that of the controls (16+/-4 vs. 33+/-5%, P < 0.05), indicating that a marked reduction in flux through glycogen synthase was responsible for the reduced rate of net glycogen synthesis in the IDDM subjects. 31P-NMR spectroscopy was used to determine the intramuscular concentration of glucose-6-phosphate (G-6-P) under the same hyperglycemic-hyperinsulinemic conditions. Basal G-6-P concentration was similar between the two groups (approximately 0.10 mmol/kg of muscle) but the increment in G-6-P concentration in response to the glucose-insulin infusion was approximately 50% less in the IDDM subjects compared with the control subjects (0.07+/-0.02 vs. 0.13+/-0.02 mmol/kg of muscle, P < 0.05). When nonoxidative glucose metabolic rates in the control subjects were matched to the IDDM subjects, the increment in the G-6-P concentration (0.06+/-0.02 mmol/kg of muscle) was no different than that in the IDDM subjects. Together, these data indicate that defective glucose transport/phosphorylation is the major factor responsible for the lower rate of muscle glycogen synthesis in the poorly controlled insulin-dependent diabetic subjects.
SOME OBSERVATIONS ON USE OF ROENTGEN RAY IN DIAGNOSIS OF PERICARDITIS
Authors: GEORGE W. HOLMES
Journal: JAMA (1924)

In January, 1920, I1published the results of some experiments carried on during that year at the Massachusetts General Hospital to determine the character of the changes taking place in the heart shadow when fluid accumulates within the pericardial sac. I also discussed the roentgen-ray findings in pericarditis as described in the literature, and reported the results obtained in our clinic by the use of roentgen rays in this disease up to that date.  I shall review briefly the results of our previous studies with the technic used to obtain the data that we believe essential, before giving an opinion as to the presence or absence of pericarditis, and report the results obtained with this technic during the last four years.  The experimental work done consisted of studies made on fresh hearts suspended in mediums of varying specific gravity, the lightest being air and the heaviest being salt solution
SCINTIGRAPHY OF ACUTE INFLAMMATORY LESIONS WITH HUMAN CHEMOKINES
Authors: R. V. Hay, R. S. Skinner, O. C. Newman, S. L. Kunkel, L. R. Lyle, B. Shapiro, M. D. Gross
Journal: Clinical Nuclear Medicine (1994)

Hay, R. V.; Skinner, R. S.; Newman, O. C.; Kunkel, S. L.; Lyle, L. R.; Shapiro, B.; Gross, M. D. Author Information
Peripheral Neuropathy Caused by Arsenical Intoxication
Authors: Albert Heyman, John B. Pfeiffer, Robert W. Willett, Haywood M. Taylor
Journal: New England Journal of Medicine (1956)

EARLY in the present century lesions of the peripheral nerves caused by arsenical intoxication were a frequent occurrence. In most cases the neuropathy could be attributed to contact with the many household articles such as dyes, wallpaper and insecticides that contained large quantities of arsenic. In recent years, exposure to arsenic has been greatly reduced, and arsenical intoxication is no longer considered a common cause of peripheral neuropathy. Dusts and sprays containing arsenic, however, continue to be extensively employed as pesticides on farms in North Carolina, and their accidental ingestion or inhalation has produced numerous cases of poisoning. Our experience . . .
Resolution of Experimental Pulmonary Emboli with Heparin and Streptokinase in Different Dosage Regimens
Authors: J. F. Cade, J. Hirsh, E. Regoeczi, M. Gent, M. R. Buchanan, D. M. Hynes
Journal: Journal of Clinical Investigation (1974)

Thrombolytic agents may be useful in acute pulmonary embolism, but their optimal dosage remains uncertain. We have examined the relative efficacy of heparin and different doses of streptokinase, either alone or in combination, in acute experimental pulmonary embolism. A standardized massive embolus of autologous blood clot incorporating canine [125I]-fibrinogen was given to 40 dogs; the degree of resolution after 24 h was quantitated by measuring the radioactivity in the lungs and was compared with detailed postmortem observations.
An obstinate patient
Authors: Shyam Kothari
Journal: BMJ (2004)

Just as a runner passes on the baton to the next one in a relay race, so she gave birth to her daughter and died. In the antiseptic environment of an obstetric theatre, I witnessed this spectacle with the detachment of a duty conscious executioner. I had talked frankly with the patient in the weeks before, and had explained point blank the …
Direct cell entry of gold/iron-oxide magnetic nanoparticles in adenovirus mediated gene delivery
Authors: Kazumasa Kamei, Yohei Mukai, Hiroki Kojima, Tomoaki Yoshikawa, Mai Yoshikawa, George Kiyohara, Takao A. Yamamoto, Yasuo Yoshioka, Naoki Okada, Satoshi Seino, Shinsaku Nakagawa
Journal: Biomaterials (2009)
Insulin-Induced Stimulation of Gastric Acid Secretion
Authors: Michael A. Polacek, Edwin H. Ellison
Journal: JAMA (1963)

IT HAS BEEN WELL ESTABLISHED that parenteral insulin given in amounts sufficient to lower the blood sugar below 40 to 50 mg% stimulates gastric acid secretion within 1 to 2 hr in the vagally innervated stomach.<sup>1,2</sup>Since vagotomy eliminates this response, insulin-induced gastric secretion has been thought to result from hypoglycemic stimulation of a parasympathetic center in the brain. It is not the insulin in itself which affects the central nervous system center, but the critical level of hypoglycemia it produces. The reasons for this conclusion include the observation that the blood sugar must be below 50 mg% to obtain a secretory response. Also, diabetics with high fasting blood sugars (FBS) require a much greater dose of insulin, compared with nondiabetics, to obtain the same critical hypoglycemic level or again the gastric secretory response will not become manifest. Furthermore, regardless of the amount of insulin administered, if the induced
Alcohol consumption, cardiovascular risk factors, and mortality in two Chicago epidemiologic studies.
Authors: A R Dyer, J Stamler, O Paul, D M Berkson, M H Lepper, H McKean, R B Shekelle, H A Lindberg, D Garside
Journal: Circulation (1977)

Multivariate analysis of the association at baseline between problem drinking and cardiovascular risk factors among 1,233 white male employees of the Chicago Peoples Gas Company age 40-59 showed the 38 problem drinkers with significantly higher blood pressures and cigarette consumption and significantly lower relative weights than the others. Similar analysis among 1,899 white male employees of the Hawthorne Works of the Western Electric Company in Chicago age 40-55 showed the 117 men consuming 5 or more drinks per day with significantly higher blood pressures and cigarette use than the others. No significant differences were recorded between heavy drinkers and the others in serum cholesterol level. The gas company problem drinkers had significantly higher 15-year mortality rates from all causes, cardiovascular diseases, coronary heart disease, and sudden death. These differences could not be entirely explained by their blood pressure, smoking, and relative weight status. The Western Electric heavy drinkers had increased 10-year mortality rates both for all causes and noncardiovascular causes.
Factors associated with difference in prevalence of asthma in children from three cities in China: multicentre epidemiological survey
Authors: Gary W K Wong, Fanny W S Ko, David S C Hui, Tai F Fok, David Carr, Erika von Mutius, Nan S Zhong, Yu Z Chen, Christopher K W Lai
Journal: BMJ (2004)

<h3>Abstract</h3> <b>Objective</b> To determine the factors associated with difference in prevalence of asthma in children in different regions of China. <b>Design</b> Multicentre epidemiological survey. <b>Setting</b> Three cities in China. <b>Participants</b> 10 902 schoolchildren aged 10 years. <b>Main outcome measures</b> Asthma and atopic symptoms, atopic sensitisation, and early and current exposure to environmental factors. <b>Results</b> Children from Hong Kong had a significantly higher prevalence of wheeze in the past year than those from Guangzhou and Beijing (odds ratio 1.64, 95% confidence interval 1.35 to 1.99). Factors during the first year of life and currently that were significantly associated with wheeze were cooking with gas (odds ratio 2.04, 1.34 to 3.13), foam pillows (2.58, 1.66 to 3.99), and damp housing (1.89, 1.26 to 2.83). Factors protecting against wheeze were cotton quilts and the consumption of fruit and raw vegetables. <b>Conclusion</b> Environmental factors and diet may explain the differences in prevalence of asthma between children living in different regions of China.
Suppression of endogenous murine leukemia virus by maternal resistance factor.
Authors: M Melamedoff, F Lilly, M L Duran-Reynals
Journal: The Journal of Experimental Medicine (1983)

Females of the RF and SJL inbred mouse strains transmit to their progeny of both sexes a nonmendelian maternal resistance factor (MRF) able to suppress the expression of endogenous ecotropic murine leukemia virus (E-MuLV). This MRF is demonstrable in crosses with AKR mice by comparing E-MuLV expression in the spleens and thymuses of reciprocal F1 generations. DBA/2 and ST/b mice are MRF negative by these criteria. Neonatal inoculation of E-MuLV-containing spleen extracts gives rise to persistent expression of infectious virus in mice of the MRF- but not the MRF+ strains. However, inoculation of the virus in 30-d-old females of the MRF- strains no longer leads to a state of persistent infection; instead, these females become MRF+ and transmit protection against E-MuLV expression to their progeny by AKR and RF males. The MRF appears to be transmitted to the progeny mainly through the milk, since foster-nursing AKR neonates on RF (but not DBA/2) mothers greatly reduces E-MuLV expression in the progeny. These RF-fostered AKR mice also show a reduced and delayed lymphoma incidence, a finding consistent with the idea that maternally transmitted resistance to E-MuLV expression is the basis for the classic maternal resistance to lymphomagenesis seen in the progeny of RF mothers.
Comparison of the Nuclear Matrix Protein 22 with Voided Urine Cytology and BTA stat Test in the Diagnosis of Transitional Cell Carcinoma of the Bladder
Authors: Sinan S&ouml;zen, Hasan Biri, Zafer S&inodot;n&inodot;k, Bora K&uuml;peli, Turgut Alkibay, &Idot;brahim Bozk&inodot;rl&inodot;
Journal: European Urology (1999)
Tick Paralysis
Authors: F. W. Henderson
Journal: JAMA (1961)

SEVERAL reviews of tick paralysis have been written, two of which are oustanding for their completeness.<sup>1, 2</sup>I would refer you to them for historical data and statistics up to the time of their publication. This disease has been reported in North America, Australia, Africa, and Europe. In the United States it is endemic in the Northwest, yet it has been reported in 15 out of 50 states. To my knowledge only one case has been reported from Florida<sup>3</sup>prior to the present case, though no doubt others have been seen. Tick paralysis in dogs in Florida is quite common and is well known to the natives and veterinarians. <h3>Definition</h3> By definition, tick paralysis is a disease of animals and man manifested by an ascending motor paralysis and incoordination, with or without sensory changes, following the bite of either a wood tick (<i>Dermacentor andersoni Stiles</i>) or a dog
Heterogeneity of cholesterol homeostasis in man. Response to changes in dietary fat quality and cholesterol quantity.
Authors: D J McNamara, R Kolb, T S Parker, H Batwin, P Samuel, C D Brown, E H Ahrens
Journal: Journal of Clinical Investigation (1987)

Studies were carried out to examine the effects of dietary fat and cholesterol on cholesterol homeostasis in man. 75 12-wk studies were carried out during intake of 35% of calories as either saturated or polyunsaturated fat, first low and then high in dietary cholesterol. Dietary fat and cholesterol intakes, plasma lipid and lipoprotein levels, cholesterol absorption and sterol synthesis in isolated blood mononuclear leukocytes were measured during each diet period. In 69% of the studies the subjects compensated for the increased cholesterol intake by decreasing cholesterol fractional absorption and/or endogenous cholesterol synthesis. When an increase in plasma cholesterol levels was observed there was a failure to suppress endogenous cholesterol synthesis. Plasma cholesterol levels were more sensitive to dietary fat quality than to cholesterol quantity. The results demonstrate that the responses to dietary cholesterol and fat are highly individualized and that most individuals have effective feedback control mechanisms.
The p150Glued CAP-Gly Domain Regulates Initiation of Retrograde Transport at Synaptic Termini
Authors: Thomas E. Lloyd, James Machamer, Kathleen O'Hara, Ji Han Kim, Sarah E. Collins, Man Y. Wong, Brooke Sahin, Wendy Imlach, Yunpeng Yang, Edwin S. Levitan, Brian D. McCabe, Alex L. Kolodkin
Journal: Neuron (2012)
Superiority of sequential docetaxel over standard FE100C in patients with intermediate risk breast cancer: survival results of the randomized intergroup phase III trial EC-Doc.
Authors: U Nitz, J Huober, B Lisboa, N Harbeck, H Fischer, V Moebus, G Hoffmann, D Augustin, E Weiss, O Gluz, W Kuhn
Journal: Cancer Research (2009)

Abstract Abstract #78 Background: Taxane based adjuvant chemotherapy (CHT) is standard of care in node-positive breast cancer. Several pre-planned subgroup analyses detected the maximum benefit from taxanes in patients with 1-3 positive lymph nodes (LN).&amp;#x2028; According to the St. Gallen consensus CHT in endocrine responsive tumors is optional in these patients. Recently the ABCSG reported excellent survival data after endocrine therapy +/- bisphosphonates without CHT in low to intermediate risk breast cancer (Gnant et al., ASCO 2008). The EC-Doc trial compares a modern sequential taxane-based regimen with standard FE100C in patients with 1-3 positive LN.&amp;#x2028; Methods: Patients from 18 to 65 years with primary breast cancer and 1 to 3 positive LN were eligible if they had operable breast cancer with histologically confirmed free margins. M0 status was assessed by conventional staging. 2011 patients were randomized to a phase III trial comparing 4 cycles E90C600 q3w followed by 4 cycles of Docetaxel100 q3w (n=1008) (Arm A) versus 6 cycles of F500E100C500 q3w (n=828) or C600M40F600 d1, 8 q4w (n=175) (Arm B). The primary endpoint is EFS. Secondary endpoints are OS, toxicity and quality of life.&amp;#x2028; Results: Baseline characteristics were well balanced between both study arms. Arm A/B: mean age 51.5/51.5 years, median tumor size 2.0/2.0, HR positive 77.7% / 78.3%, G3 34.1% / 34.4%. Toxicity data from the EC-Doc trial were recently presented (Nitz et al. , ASCO 2008). After a median follow up of 41 months both estimated 5-year EFS (91% vs. 86%, p=0.005) and OS (95% vs. 90%, p=0.004) were significantly better in the EC-Doc arm.&amp;#x2028; For the comparison of EC-Doc vs. FE100C the respective values were: HR 0.58, p=0.004, estimated 5 year EFS 91% / 85% and 5 year estimated OS 95% / 91% (p =0.03). For the hormone receptor positive subpopulation the HR was 0.51 in favour of EC-Doc (p= 0.007).&amp;#x2028; Conclusions: Our study indicates a superiority of sequential taxane-based EC-Doc CHT in terms of EFS and OS over standard FE100C in an intermediate risk group. The addition of modern third generation taxane based CHT to conventional endocrine treatment is associated with excellent EFS and OS in patients with 1-3 positive LN.&amp;#x2028; As shown even for the subgroup of patients with HR positive disease the benefit from third generation taxane based CHT is substantial so that an endocrine only adjuvant strategy may result in undertreatment. With respect to the excellent survival rates prospective randomized trials testing the existing genetic tests are mandatory.&amp;#x2028; Updated survival and efficacy analysis in distinct molecular subtypes (Her-2/neu, triple-negative) will be presented. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 78.