THE SIGNIFICANCE OF URINARY pH: CRITICAL OBSERVATIONS
Authors: Milton A. Bridges, Marjorie R. Mattice
Journal: Annals of Internal Medicine (1941)

Article1 January 1941THE SIGNIFICANCE OF URINARY pH: CRITICAL OBSERVATIONSMILTON A. BRIDGES, M.D., F.A.C.P., MARJORIE R. MATTICE, M.S.MILTON A. BRIDGES, M.D., F.A.C.P., MARJORIE R. MATTICE, M.S.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-7-1123 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt would appear to be unnecessary to discuss so simple a matter as urinary reaction but the average clinician not infrequently is puzzled by apparent inconsistencies and opinions which are expressed as fact. Although reaction can be interpreted as titratable acidity with or without additional data, present comments will be restricted almost entirely to reaction as measured by pH.NORMAL URINARY REACTIONHenderson and Palmer1reported a normal range of urinary pH of 4.82 to 7.45 with a mean of 6.03. Later2a value of 8.7 was achieved after administration of excessive amounts of sodium bicarbonate and pH 4.7 was...Bibliography1. HENDERSONPALMER LJWW: Intensity of urinary acidity, Jr. Biol. Chem., 1913, xiii, 393. CrossrefGoogle Scholar2. HENDERSONPALMER LJWW: On the extremes of variation of the concentration of ionized hydrogen in human urine, Jr. Biol. Chem., 1913, xiv, 81. CrossrefGoogle Scholar3. NEWBURGHPALMERHENDERSON LHWWLJ: Hydrogen-ion concentration of the urine in heart disease, Arch. Int. Med., 1913, xii, 146. CrossrefGoogle Scholar4. HENDERSONPALMER LJWW: On the several factors of acid excretion, Jr. Biol. Chem., 1914, xvii, 305. CrossrefGoogle Scholar5. MASLOW LA: Urinary pH and crystallography, Jr. Urol., 1936, xxxv, 674. CrossrefGoogle Scholar6. FISCHER MH: Edema and nephritis, 2d edition, 1915, John Wiley and Sons, New York. Google Scholar7. BOWMANPITTS RDHC: Calcium and phosphatase studies in cancer of female sex with consideration of basal metabolic rate and urine pH, Am. Jr. Obst. and Gynec., 1936, xxxii, 957. CrossrefGoogle Scholar8. LLOYD-WILLIAMs IH: Musings on urinary pH values, Jr. Roy. Army Med. Corps, 1939, lxxii, 123. Google Scholar9. MARSHALL EK: The effect of loss of carbon dioxide on the hydrogen-ion concentration of urine, Jr. Biol. Chem., 1922, li, 3. CrossrefGoogle Scholar10. DAVIESHALDANEKENNAWAY HWJBEL: Experiments on regulation of the blood's alkalinity, Jr. Physiol., 1920, liv, 32. CrossrefGoogle Scholar11. BRIDGESMATTICE MAMR: Control of urine reaction, Am. Jr. Med. Sci., 1940, cc, 84. CrossrefGoogle Scholar12. ZIEGLERBRICE EEAT: Reaction and specific gravity of the urine in relation to nephritis (a study of ten thousand urinalyses), ANN. INT. MED., 1937, xi, 768. Google Scholar13. BRIDGESMATTICE MAMR: Over two thousand estimations of the pH of representative foods, Am. Jr. Digest. Dis., 1939, vi, 440. CrossrefGoogle Scholar14. BRIDGESMATTICE MAMR: Unpublished observations. Google Scholar15. SCHRADER JC: Alkalosis, Jr. Iowa State Med. Soc., 1929, xix, 179. Google Scholar16. NICOL BM: Renal changes in alkalosis, Quart. Jr. Med., 1940, ix, 91. Google Scholar17. WAYMUNTWYLER CTE: Alkalosis, a clinical problem, ANN. INT. MED., 1935, viii, 818. Google Scholar18. MYERSBOOHER VCLE: Observations on the excretion of an acid urine in alkalosis, Proc. Soc. Exper. Biol. and Med., 1925, xxii, 512. CrossrefGoogle Scholar19. PALMERSALVESENJACKSON WWHH: Relationship between the plasma bicarbonate and urinary acidity following the administration of sodium bicarbonate, Jr. Biol. Chem., 1920, xlv, 101. CrossrefGoogle Scholar20. STIEGLITZ EJ: Histologic hydrogen-ion studies of the kidneys, Arch. Int. Med., 1924, xxxiii, 483. CrossrefGoogle Scholar21. CRANCEMALONEY AMTW: A new acid medication in the treatment of bacilluria, Jr. Urol., 1935, xxxiii, 657. CrossrefGoogle Scholar22. SHOHLBUTLER ATAM: Citrates in the treatment of infantile rickets, New England Jr. Med., 1939, ccxx, 515. CrossrefGoogle Scholar23. MCCLELLANGOLDSTEIN WSR: The pH of the urine as influenced by the ingestion of alkaline mineral waters, Jr. Clin. Invest. (Proc.), 1938, xvii, 516. Google Scholar24. BESTTAYLOR CHNB: The physiological basis of medical practice, 1937, Wm. Wood and Co., Baltimore. Google Scholar25. MASONHELLBAUM ECAA: Acid-base water balance, ANN. INT. MED., 1938, xi, 2206. Google Scholar26. BERGERBINGER EHMW: The status of the kidneys in alkalosis, Jr. Am. Med. Assoc., 1935, civ, 1383. CrossrefGoogle Scholar27. STEELE JM: Renal insufficiency developing during prolonged use of alkalies, Jr. Am. Med. Assoc., 1936, cvi, 2049. CrossrefGoogle Scholar28. LASHMET FH: The treatment of nephritic edema by acid, Jr. Am. Med. Assoc., 1931, xcvii, 918. CrossrefGoogle Scholar29. HARDTRIVERS LLAB: Toxic manifestations following the alkaline treatment of peptic ulcer, Arch. Int. Med., 1923, xxxi, 171. CrossrefGoogle Scholar30. SHATTUCKROHDENBURGBOOHER HFELLE: Antacids in medical management of peptic ulcer, Jr. Am. Med. Assoc., 1924, lxxxii, 200. CrossrefGoogle Scholar31. MCGEEMARTINLEVYPURDUM LCJEFRB: The influence of alkalis on renal function, Am. Jr. Digest. Dis., 1939, vi, 186. CrossrefGoogle Scholar32. STIEGLITZ EJ: Alkalis and renal injury, Arch. Int. Med., 1928, xli, 10. CrossrefGoogle Scholar33. MCGOWINOSTERHAGENANDERSCH ELHFM: Effect upon renal insufficiency from transfusion, Arch. Int. Med., 1937, lix, 432. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication May 20, 1940.From the Department of Medicine, N. Y. Post-Graduate Medical School and Hospital, Columbia University, New York, N. Y.†Deceased. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTwo–Dimensional Disposable Graphene Sensor to Detect Na+ IonsAcid/alkaline ash diets: Time for assessment and changeUrinary pHThe Effect of Urine on Entamoeba Histolytica 1 January 1941Volume 14, Issue 7Page: 1123-1136KeywordsBicarbonatesHospital medicineSodium ePublished: 1 December 2008 Issue Published: 1 January 1941 Copyright & PermissionsCopyright, 1941, by The American College of PhysiciansPDF downloadLoading ...