tbuckley/cabot-search huggingface dataset:
Regression of left ventricular hypertrophy in hypertensive heart transplant recipients treated with enalapril, furosemide, and verapamil.
Authors: C E Angermann, C H Spes, S Willems, P Dominiak, B M Kemkes, K Theisen
Journal: Circulation (1991)

BACKGROUND This prospective study was designed to examine whether left ventricular (LV) hypertrophy of the denervated transplanted heart may be reversed by medical therapy and, if so, to investigate the time course of this process and its effect on exercise capacity, myocardial function, and cardiac hemodynamics. METHODS AND RESULTS Ten hypertensive heart transplant recipients with LV hypertrophy were evaluated before therapy with enalapril plus furosemide alone or combined with verapamil, at initial blood pressure (BP) control and after 3, 6, 9, and 12 months, using 24-hour noninvasive ambulatory BP monitoring, M-mode and two-dimensional echocardiography, and supine bicycle ergometry. Average 24-hour systolic and diastolic BP declined from 158 +/- 10 and 104 +/- 7 mm Hg to 129 +/- 9 and 84 +/- 10 mm Hg at initial BP control (p less than 0.005 and p less than 0.025, respectively) and total peripheral resistance from 1,687 +/- 177 to 1,376 +/- 122 dyne.sec.cm-5 (p less than 0.025), remaining normal thereafter. Exercise capacity remained unchanged during the study. LV mass, mass-to-volume ratio, and end-diastolic septal plus posterior wall thickness decreased progressively from 211 +/- 30 g, 2.49 +/- 0.62 g/ml, and 25.7 +/- 2.6 mm to 184 +/- 26 g, 2.22 +/- 0.46 g/ml, and 22.5 +/- 1.9 mm after 3 months (all p less than 0.025) and to 174 +/- 25 g, 2.07 +/- 0.38 g/ml, and 21.5 +/- 1.5 mm after 6 months (all p less than 0.005), remaining unaltered at 9 and 12 months. A correlation was found between the decrease in average 24-hour mean BP and LV mass after 3 months of antihypertensive therapy (r = 0.71, p less than 0.05). Systolic meridional wall stress, LV end-diastolic and stroke volume, ejection fraction, and cardiac output remained unchanged throughout the observation period. CONCLUSIONS The results indicate that regression of LV hypertrophy is induced by effective antihypertensive therapy in the denervated transplanted heart. The extent of decrease in average 24-hour BP appears to be the main determinant for the extent of reduction in LV mass. LV afterload as characterized by systolic meridional wall stress, LV size and pump function, and physical exercise capacity of the transplant patients are not influenced by the therapeutic regimen chosen in this study.
Genetic variants of complement component 3 (C3) in DR4 positive and DR4 negative rheumatoid arthritis.
Authors: W Thomson, P A Dyer, P A Sanders, D M Grennan
Journal: Annals of the Rheumatic Diseases (1986)

C3 allotypes were defined in 86 Caucasoid patients with rheumatoid arthritis living in the north west of England and in 80 local, healthy controls. C3 allotype and phenotype frequencies were similar in RA (whether DR4 positive or negative) and control groups.
The Crossroads of Oncogenesis and Metastasis
Authors: Isidro Sánchez-García
Journal: New England Journal of Medicine (2009)

The treatment of cancer is generally based on histologic grade, resectability, and the presence or absence of metastasis. Because interventions after the manifestation of metastasis are notoriously ineffective for most cancers, great effort has been invested in the development of targeted therapies to eradicate or suppress the growth of micrometastatic disease. In three recent studies,13 investigators implicate potential targets: proteins that mediate both transformation and metastasis. These studies also provide a potential clue to why some cancers have already metastasized at the time of diagnosis.The implicated proteins, twist homolog 1 (Twist-1) and two members of the zinc-finger-protein Snail . . .
Demonstration of Urinary Extravasation of a Renal Allotransplant With Tc-99m DTPA
Authors: Margaret M. LaMANNA, Simindokht Dadparvar, Luther W. Brady, Patricia Lyons, Robert Chvala, Simon Simonian
Journal: Clinical Nuclear Medicine (1983)

LAMANNA, MARGARET M. M.D.; DADPARVAR, SIMINDOKHT M.D.; BRADY, LUTHER W. M.D; LYONS, PATRICIA M.D.; CHVALA, ROBERT M.D.; SIMONIAN, SIMON M.D., Sc.D. Author Information
EASL Recognition Awardee 2012
Authors: Carlo Merkel
Journal: Journal of Hepatology (2012)

It is a privilege and an honour to introduce, on behalf of EASL, Professor Helmer Ring-Larsen, on the occasion of the EASL 2012 recognition award ceremony. Helmer Ring-Larsen is Professor of Pharmacotherapy at the Faculty of Pharmaceutical Sciences of the University of Copenhagen, and Emeritus Consultant at the Department of Medicine and Hepatology, Rigshospitalet in Copenhagen. He was born in Copenhagen in 1939, and studied at the University of Copenhagen, where he graduated in 1967. He then spent 2 years as an Intern at the University of Missouri in Kansas City. Upon his return to Denmark, he spent 1 year as Lieutenant Physician in the Danish Navy, on board a Rescue Ship based in the Faer Oer Islands, and then completed his education at the Department of Medicine of Rigshospitalet Copenhagen, under Professor Niels Tygstrup, who remained a reference throughout his scientific career. In 1983, he obtained a Ph.D. in Medical Sciences, with a thesis on ‘‘Hepatic Nephropathy, related to Hemodynamics’’, a topic which was to become key to his scientific interests. Over this period, his interest in the pathophysiology of renal and splanchnic circulation was clearly influenced by contact and relationship with a prominent Danish physiologist, Professor Kjeld Winkler. He soon became a member and then headed a study group dedicated to renal circulatory problems in advanced liver disease, including ascites and hepato-renal syndrome. At the beginning, his closest co-workers were Birger Hesse (a cardiologist) and Jens Henriksen (a clinical physiologist). Several eminent scientists started their careers within this group, including Flemming Bendtsen (who went on to become an expert in the endoscopic treatment of varices), Hendrik Vilstrup (currently secretary of the International Society of Hepatic Encephalopathy), Christian Gluud (the leader of the Cochrane Hepatobiliary Group), Soeren Moeller (who dedicated his research to the pathophysiology of ascites), Peter Ott (an expert in the evaluation of liver function), Axel Malchow-Moeller (who worked on jaundice), and Fin Stolze-Larsen (who went on to become a reference figure in the field of acute liver failure). Professor Ring-Larsen is the author of 132 papers published in international journals. His first scientific achievements, in the ‘70s, were related to surgical portal-systemic shunts and their
Maternal mortality in the former East Germany before and after reunification: changes in risk by marital status
Authors: O. Razum, A. Jahn, R. Snow
Journal: BMJ (1999)

This paper examines the impact of marital status on maternal mortality in the period before and the period after German reunification in the area covered by the former East Germany. Maternal mortality ratio prior to the reunification was stable and declined after reunification. This can be attributed to the adoption of a lenient reporting system from West Germany. Unmarried status, on the other hand, became a significant risk factor for maternal mortality after reunification due to changes in support program for pregnant women and mothers, and socioeconomic factors. Elimination of support measures like incentives for check-ups, follow-ups, and guaranteed jobs for single mothers in eastern Germany before the reunification explains the increased maternal mortality rate. In West Germany, unmarried women were associated with low socioeconomic status. Conditions of higher maternal risk and lower socioeconomic status among unmarried mothers from East Germany is now similar to the situation of unmarried mothers in West Germany.
Search for better inotropic drugs should continue
Authors: J. A Lee, D. G Allen
Journal: BMJ (1998)

EDITOR—In their editorial on drug treatment in heart failure, Steeds and Channer state that “all clinical trials of positively inotropic drugs have either failed to improve symptoms or have increased mortality in heart failure.”1 Even if this statement is allowed, it is a generalisation too far to conclude that “drugs that increase the force of contraction of the failing heart result in increased mortality and…there should be a halt on further …
The Mechanism of Interaction between Visual Flow and Eye Velocity Signals for Heading Perception
Authors: Albert V. van den Berg, Jaap A. Beintema
Journal: Neuron (2000)

A translating eye receives a radial pattern of motion that is centered on the direction of heading. If the eye is rotating and translating, visual and extraretinal signals help to cancel the rotation and to perceive heading correctly. This involves (1) an interaction between visual and eye movement signals and (2) a motion template stage that analyzes the pattern of visual motion. Early interaction leads to motion templates that integrate head-centered motion signals in the visual field. Integration of retinal motion signals leads to late interaction. Here, we show that retinal flow limits precision of heading. This result argues against an early, vector subtraction type of interaction, but is consistent with a late, gain field type of interaction with eye velocity signals and neurophysiological findings in area MST of the monkey.
Contraceptive steroids as a risk factor for hepatocellular carcinoma: A case/control study in south african black women
Authors: Michael C. Kew, Ernest Song, Abdullah Mohammed, John Hodkinson
Journal: Hepatology (1990)

The role of contraceptive steroids in the etiology or pathogenesis of hepatocellular carcinoma in urban South African black women was investigated in a hospital–based case and control study. Participating were 46 women, 19 to 54 yr old, with carcinoma, and 92 matched controls. South African blacks have a high incidence of hepatocellular carcinoma, and urban black women have used contraceptive steroids fairly widely for a number of years. Use of contraceptive steroids for longer than 6 mo (mean duration 46.7 mo) was not found to pose a risk for development of hepatocellular carcinoma in this population-relative risk 0.8 (95% confidence interval [C. I.] 0.4 to 1.7). This was also true of use for longer than 8 yr-relative risk 0.6 (95% C. I. 0.2 to 2.5), and if a combination of an estrogen and a progestogen or a progestogen alone was used (relative risk 1.7 [95% C. I. 0.7 to 4.2] and 0.4 [95% C. I. 0.1 to 1.2], respectively). Chronic hepatitis B virus infection was confirmed to have an etiological association with hepatocellular carcinoma, but there was no evidence that contraceptive steroids acted as a co–carcinogen with the virus or, conversely, that they played a causal role in patients negative for hepatitis B surface antigenemia. We cannot, however, exclude the possibility that contraceptive steroids may play a causal role in hepatocellular carcinoma in black women who have never been infected with the hepatitis B virus. Nor was there evidence that contraceptive steroids acted in concert with either cigarette smoking or chronic alcohol abuse in hepatocarcinogenesis. We conclude that contraceptive steroids cannot at present be incriminated as a risk factor for the development of hepatocellular carcinoma in South African black women.
A Syndrome Due to Transient or Changing Heart-block
Authors: P. B. S. Fowler
Journal: BMJ (1962)

EPIDURAL ANALGESIA BRrIISHevent 40 minutes or even longer after epidural injection of what might have seemed a not too excessiv_e dose in a patient of normal biological age. SummaryInjection of local anaesthetic solutions into the spinal extradural space results in a segmental type of analgesia.In normal subjects the number of analgesic dermatomos can be predicted with an accuracy of 15 to 30(,%b in terms of age and the concentration and volume of local anaes- thetic used.The amount of local anaesthetic required to block a given area declines steadily after the second decade, in a manner reminiscent of some other curves relating biological phenomena to age.Fifty-three patients with occlusive vascular disease reacted abnormally to epidural analgesia.They behaved as if they were 25 to 50 years older than their chrono- logical age, or as if the injected solution had been twice the concentration actually used.In these patients segmental analgesia spread one and a half to three times further than in normal subjects of the same age.This tendency to increased spread can be hazardous if the anaesthetist is not aware of the necessity for reduced dosage in arteriosclerotic patients.The timen taken for epidural analgesia to reach its farthest limits varies quite widely in normal subjects, and does not appear to be dependent on age.This time interval is prolonged in arteriosclerotic patients.The significance of these findings is discussed in relation to the effects of ageing processes, and to the site of action of epidural analgesia.I am grateful to my col!eagues in the Department of
Alan Edward Malone
Authors: Judy Malone
Journal: BMJ (2004)

Former general practitioner Southampton (b London 1922; q London 1946; FRCGP), died on 14 July from a massive stroke.​stroke.




Figure 1




He played hockey with distinction for the hospital, London University, United Hospitals, and English Universities. After two years' service in the Royal Air Force he settled in Southampton, where he was later appointed life honorary teacher in general practice to the medical school. He was the first GP tutor in Southampton responsible for postgraduate GP education. He was elected a fellow of the BMA. After retirement he settled in Bristol, thoroughly enjoying his life there, particularly the excellent music available in the city. He leaves three daughters and seven grandchildren.
Clinical Lecture on the Significance of Paralysis after Injuries to the Head
Authors: J. Hutchinson
Journal: BMJ (1868)

GENTLEMEN, -The case of the man whom you saw on Thursday in Richmond ward, and whose brain is now before us, has proved to be of unusual interest.At first sight, it appears to contradict some of the conclusions which I have ventured to state in previous lectures.The ma1, to whom I refer, was brought in on Tuesday evening at six c'clock.He had fallen into a ship's hold.He was bleeding from his left ear, and a small portion of brain-substance lay in the meatus.There was therefore no doubt as to his having sustained a fracture of the base of the skull, and that the fracture implicated his left petrous bone.He was carried to bed, and I did not see him till twenty hours later.At
Long‐Term Modification on Histamine‐Induced Bronchoconstriction by Disodium Cromoglycate and Ketotifen versus Placebo
Authors: F. Gozalo Reques, C. Colas Sanz, C. Senent Sanchez, M. Rubio Sotes, T. Herrero Lopez, M. de Barrio Fernandez
Journal: Allergy (1985)

In order to compare long‐term changes induced on a wide spectrum of bronchial hyperreactivity (BH) by the antiallergic drugs disodium cromyglycate (DSCG) and ketotifen, 56 asthmatic patients (age range 15–55 years) were studied. Patients were allocated to three groups with similar age and BH level. During 2 months, 15 individuals inhaled 20 mg DSCG four times a day, 14 took ketotifen 1 mg twice a day orally and 14 one placebo (lactose) capsule twice a day. After preliminary results, an additional group of 13 patients took clemastine 1 mg orally twice a day for 1 week. Only the ketotifen and clemastine groups differed significantly from the placebo group on shifting log doseresponse curves of inhaled histamine. In addition, no significant difference was seen between the ketotifen and clemastine groups. These results suggest that changes induced by ketotifen were mainly related to its powerful antihistamine action; similarly, nonspecific BH is not wholly dependent on mediator release.
CRITERIA FOR SUCCESS OF LEFT ATRIAL APPENDAGE LIGATION BY A NOVEL CATHETER-BASED SUTURE LIGATION PROCEDURE
Authors: Randall J. Lee, Krzysztof Bartus, Jacek Bednarek, Jacek Myc, Boguslaw Kapelak, Jacek Lelakowski, Jerzy Sadowski, Steven J. Yakubov
Journal: Journal of the American College of Cardiology (2011)
The hepatic circulation in health and disease: Report of a single-topic symposium
Authors: Vijay Shah, Guillermo García-Cardeña, William C. Sessa, Roberto J. Groszmann
Journal: Hepatology (1998)

Blood flow and vascular resistance in the hepatic vasculature are closely regulated through a balance of vasoactive molecules including nitric oxide (NO), carbon monoxide (CO), endothelin (ET), and prostanoids such as prostacyclin.These vasoregulatory agents interact with unique nonparenchymal cells in the hepatic sinusoid through autocrine and paracrine mechanisms.These cells, which include sinusoidal endothelial cells (SEC), hepatic stellate cells (HSC), and Kupffer cells (KC), each have the molecular machinery to synthesize and/or respond to these vasoactive molecules.This complex interaction of cells and molecules, although not well understood, appears to involve vasoregulatory mechanisms that are unique to the hepatic vascular bed.Alterations in the function of the cells lining the sinusoids and in the activity of vasoactive mediators in the hepatic circulation play a role in mediating vascular disturbances which may arise in the liver secondary to cirrhosis, sepsis, and liver transplantation.Thus, understanding the mechanisms which regulate blood flow in the hepatic circulation are of vital importance.On June 21-22, 1996, the American Association for the Study of Liver Diseases sponsored a symposium entitled ''Liver Microcirculation in Health and Diseases.''The purpose of this conference was to review current basic research endeavors pertaining to the hepatic circulation.The conference was organized into four sessions, with each session composed of several lectures.This article will summarize the salient aspects of each lecture based on summaries submitted by the speaker and modified based on dictations of the lecture.The first section, entitled ''Endothelial and Smooth Muscle Regulation of Vascular Function,'' chaired by William C. Sessa and Roberto J. Groszmann, examined basic mechanisms of vascular regulation, with particular emphasis on the physiology and biology of the endothelial cell and its modulation by other cell types, vasoactive mediators, and biomechanical forces.The second section, entitled ''The Liver Microcirculation,'' chaired by Robert S. McCuskey and Jurg Reichen, addressed anatomic and physiological studies in the hepatic circulation and novel characteristics of HSC.The third section, entitled ''Pathogenesis of Portal Hypertension,'' chaired by Jaime Bosch and Didier LeBrec, examined mechanisms that may account for the hemodynamic disturbances in the liver and other regional beds that are characteristic of chronic liver disease.The fourth section, entitled ''Sepsis and Transplantation,'' chaired by Ian R. Wanless and Andres T. Blei, discussed the mechanisms that mediate the microvascular injury often observed after liver transplantation and during sepsis.
Malarial Retinopathy in Adults
Authors: Richard Maude, Abdullah Abu Sayeed, Nicholas Beare, Prakaykaew Charunwatthana, M. Abul Faiz, Amir Hossain, Emran Bin Yunus, M. Gofranul Hoque, Mahtab Uddin Hasan, Nicholas White, Nicholas Day, Arjen Dondorp
Journal: Journal of Infection (2011)
Massive Blastic Infiltration of the Liver: A Cause of Fulminant Hepatic Failure
Authors: Elie S. Zafrani, Bernard Leclercq, Jean-Paul Vernant, Yvon Pinaudeau, Guy Chomette, Daniel Dhumeaux
Journal: Hepatology (1983)

The clinical and pathological findings in four cases of fulminant hepatic failure due to massive infiltration of the liver by acute leukemia or lymphoma are reported. Liver abnormalities were found simultaneously with or led to the discovery of hematologic malignancies, and consisted of marked hepatomegaly and severe hepatocellular insufficiency associated with hyperlactatemia. The blood malignancies were peculiar in their fast cellular growth and large tumor mass. Evolution was rapidly fatal in all these cases. In another patient, marked hepatomegaly and hyperlactatemia revealed the presence of a widespread lymphoma before the appearance of hepatocellular insufficiency. Immediate chemotherapy was instituted, and complete remission without hepatic complication was obtained. It is suggested that malignant hematological diseases with fast cellular growth may present as fulminant hepatic failure. In order to avoid a rapidly fatal outcome secondary to liver failure and metabolic disorders, early recognition of these malignancies is necessary so as to assure prompt administration of appropriate chemotherapy.
Humidifier fever in an operating theatre.
Authors: I A Campbell, A E Cockcroft, J H Edwards, M Jones
Journal: BMJ (1979)

The syndrome that this patient developed on sodium valproate was clinically indistinguishable from one shown by the same patient after treatment with the classical neuroleptic agent haloperidol and the dopamine antagonist metoclopramide, though it differed in its clinical response to antimuscarinic agents.These agents failed to affect the syndrome when it occurred after sodium valproate, although they effectively suppressed the identical extrapyramidal signs when they occurred after haloperidol and metoclopramide.The precise mechanisms underlying this differential responsiveness are not clear.Our observations may, however, be consistent with a report by Gerlach, who noted a clinical exacerbation of extrapyramidal symptoms after treatment with baclofen.3
Bortezomib inhibits STAT5-dependent degradation of LEF-1, inducing granulocytic differentiation in congenital neutropenia CD34+ cells
Authors: Kshama Gupta, Inna Kuznetsova, Olga Klimenkova, Maksim Klimiankou, Johann Meyer, Malcolm A. S. Moore, Cornelia Zeidler, Karl Welte, Julia Skokowa
Journal: Blood (2014)
BMJ's reply to DePuy's criticisms of article on safety of metal-on-metal hip implants
Authors: D. Cohen
Journal: BMJ (2012)

The response from DePuy representatives Graham Isaac and Simon Sinclair sidesteps the substantive concerns described in the BMJ feature on the safety of metal-on-metal hip implants.1 2 3

The main thrust of the article was the laxity of medical device regulation: a whole class of implant—in this case large diameter metal-on-metal total hip replacement—was allowed to enter the global market without any clinical studies to assess their safety and effectiveness.

The authors acknowledge that “constituents of cobalt and chromium …
Pulmonary Hypertension in Heart Disease
Authors: Craig W. Borden, Richard V. Ebert, Russell H. Wilson, Herbert S. Wells
Journal: New England Journal of Medicine (1950)

THE pulmonary circulation is of paramount importance in failure of the heart. The presence of dyspnea, orthopnea and hemoptysis and a diminution in vital capacity imply a profound change in the blood vessels of the lungs. Unfortunately, the pulmonary circulation, being effectively enclosed within the thorax, has proved inaccessible to quantitative measurements until recently.In spite of this lack of quantitative evidence, clinicians and pathologists have been able to deduce from indirect evidence the course of events in the pulmonary circulation in heart disease. The importance of hypertension of the pulmonary circulation in the natural history of mitral stenosis has . . .