THE CLINICAL IMPLICATIONS OF HYPOGAMMAGLOBULINEMIA IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AND LYMPHOCYTIC LYMPHOSARCOMA
Authors: J E ULTMANN, W FISH, E OSSERMAN, A GELLHORN
Journal: Annals of Internal Medicine (1959)

Article1 September 1959THE CLINICAL IMPLICATIONS OF HYPOGAMMAGLOBULINEMIA IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA AND LYMPHOCYTIC LYMPHOSARCOMAJOHN E. ULTMANN, WINTHROP FISH, ELLIOTT OSSERMAN, ALFRED GELLHORN, F.A.C.P.JOHN E. ULTMANNSearch for more papers by this author, WINTHROP FISHSearch for more papers by this author, ELLIOTT OSSERMANSearch for more papers by this author, ALFRED GELLHORN, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-3-501 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough many patients with agammaglobulinemia have been reported since 1952, there are few reports and surveys of serum gamma globulin depressions in association with chronic lymphocytic leukemia (CLL) and lymphocytic lymphosarcoma (LyLysa). The clinical implications of this complication are rarely mentioned. Jim and Reinhard reported one patient with agammaglobulinemia and chronic lymphocytic leukemia in 1956,1and then reviewed 49 additional patients a year later.2He noted that in his 50 unselected patients with chronic lymphocytic leukemia there was significant hypogammaglobulinemia (HGG) in about a third. Wall et al.3performed filter paper electrophoretic analyses of the sera of 495 patients with...Bibliography1. JimReinhard RTEH: Agammaglobulinemia and chronic lymphocytic leukemia, Ann. Int. Med. 44: 790, 1956. LinkGoogle Scholar2. Jim RT: Serum gamma globulin levels in chronic lymphocytic leukemia, Am. J. M. Sc. 234: 44, 1957. CrossrefMedlineGoogle Scholar3. WallSunPicklow RLLFE: Serum proteins in diseases of the reticuloendothelial system: the significance of hypogammaglobulinemia, Res. Bull. 2: 50, 1956. Google Scholar4. CreysselMorelVieuxPichatCroizatRevol RPRAPL: L'électrophorese du sérum au cours des hémopathies malignes, Sang 28: 34, 1957. MedlineGoogle Scholar5. HudsonWilson RPSJ: Hypogammaglobulinemia and chronic lymphatic leukemia, J. Lab. and Clin. Med. 50: 829, 1957. Google Scholar6. OssermanLawlor EFDP: Abnormal serum and urine proteins in thirty-five cases of multiple myeloma, as studied by filter paper electrophoresis, Am. J. Med. 18: 462, 1955. CrossrefMedlineGoogle Scholar7. LarsonTomlinson DLLJ: Quantitative antibody studies in man. III. Antibody response in leukemia and other malignant lymphomata, J. Clin. Investigation 32: 317, 1953. CrossrefMedlineGoogle Scholar8. GoodVarco RARL: A clinical and experimental study of agammaglobulinemia, Journal Lancet 75: 245, 1955. Google Scholar9. GitlinHitzigJaneway DWHCA: Multiple serum protein deficiencies in congenital and acquired agammaglobulinemia, J. Clin. Investigation 35: 1199, 1956. CrossrefMedlineGoogle Scholar10. MartinGordonMcCullough CMRSNB: Acquired hypogammaglobulinemia in an adult, New England J. Med. 254: 449, 1956. CrossrefMedlineGoogle Scholar11. BarrettVolwiler BW: Agammaglobulinemia and hypogammaglobulinemia—the first five years, J. A. M. A. 164: 866, 1957. CrossrefMedlineGoogle Scholar12. Matras A: Zoster generalisatus bei chronischer lymphatischer Leukämie, Wien. klin. Wchnschr. 66: 733, 1954. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication January 16, 1959.From the Department of Medicine, Columbia University College of Physicians and Surgeons, and the Medical Service of the Francis Delafield Hospital, New York, N. Y.†The work on which this paper is based was supported in part by a grant from the National Cancer Institute, U. S. Public Health Service, and by the Anne Winton Memorial Fund. The American Red Cross furnished the Gamma Globulin used in this study.‡A. Moon (deceased) and S. Kurland gave technical assistance in this study.Requests for reprints should be addressed to John E. Ultmann, M.D., Institute of Cancer Research, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York 32, N. Y. 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ULTMANN, M.D., PHILIP FEIGELSON, Ph.D. 1 September 1959Volume 51, Issue 3Page: 501-516KeywordsChronic lymphocytic leukemiaGlobulinsHospital medicineMedical servicesSarcomaStaphylococcal infectionStaphylococcus aureusSurgeons ePublished: 1 December 2008 Issue Published: 1 September 1959 PDF downloadLoading ...