Hypothalamic Control of Red Cell Production
Authors: ALLAN J. ERSLEV
Journal: Annals of Internal Medicine (1966)

Editorial Notes1 October 1966Hypothalamic Control of Red Cell ProductionALLAN J. ERSLEV, M.D.ALLAN J. ERSLEV, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-4-862 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is generally accepted that the control of red cell production is influenced by erythropoietin and by the tissue tension of oxygen. Clinical observations on patients in whom a reverse blood flow through a patent ductus arteriosus has caused a localized subdiaphragmatic hypoxia (1) and experimental observations on the kidneys (2) have led to the hypothesis that red cell production is regulated solely by the release of renal erythropoietin, which in turn is regulated by the renal tissue tension of oxygen. However, the persistence of red cell production in anephric man (3) and the fact that the kidney, because of...References1. STOHLMANROTHROSE FCEJC: Evidence for a humoral regulation of erythropoiesis. Blood 7: 721, 1954. CrossrefGoogle Scholar2. JACOBSONGOLDWASSERFRIEDPLZAK LOEWL: Role of the kidney in erythropoiesis. Nature (London) 179: 633, 1957. CrossrefMedlineGoogle Scholar3. NATHANSCHUPAKSTOHLMANMERRILL DGEFF: Erythropoiesis in anephric man. J. Clin. Invest. 43: 2158, 1964. CrossrefMedlineGoogle Scholar4. WALDMANNLEVINBALDWIN TAEHM: The association of polycythemia with a cerebellar hemangioblastoma. The production of an erythropoiesis stimulating factor by the tumor. Amer. J. Med. 31: 318, 1961. CrossrefMedlineGoogle Scholar5. SEIP M: Reticulocyte studies. Acta Med. Scand. 146 (suppl. 282): 1, 1953. Google Scholar6. SEIPHALVORSENANDERSENKAADA MSPBR: Effects of hypothalamic stimulation on erythropoiesis in rabbits. Scand. J. Clin. Lab. Invest. 13: 553, 1961. CrossrefMedlineGoogle Scholar7. HALVORSEN S: Effects of hypothalamic lesions on the erythropoietic response to hypoxia in rabbits. Acta Physiol. Scand. 61: 1, 1964. CrossrefMedlineGoogle Scholar8. HALVORSEN S: The central nervous system in regulation of erythropoiesis. Acta Haemat. (Basel) 35: 65, 1966. CrossrefMedlineGoogle Scholar9. MIRANDGRACEJOHNSTONMURPHY EAJTGSGP: Effect of hypothalamic stimulation on the erythropoietic response in the rhesus monkey. Nature (London) 204: 1163, 1964. CrossrefMedlineGoogle Scholar10. FELDMANRACHMILEWITZIZAK SEAG: The effect of central nervous system stimulation on erythropoiesis in rats with chronically implanted electrodes. J. Lab. Clin. Med. 67: 713, 1966. MedlineGoogle Scholar11. DENNYFLANIGANZUKOSKI WFWJCF: Serial erythropoietin studies in patients undergoing renal homotransplantation. Ibid., p. 386. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Cardeza Foundation for Hematologic Research Jefferson Medical College of Philadelphia Philadelphia, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRenal biogenesis of erythropoietinDie humorale und nervöse Regelung der Erythropoese 1 October 1966Volume 65, Issue 4Page: 862-863KeywordsBlood cellsBlood flowErythropoietinHypoxiaKidneysOxygenPatent ductus arteriosus Issue Published: 1 October 1966 PDF DownloadLoading ...