THE EARLY DIAGNOSIS AND NATURAL HISTORY OF CHRONIC LYMPHATIC LEUKEMIA
Authors: C HOUGIE
Journal: Annals of Internal Medicine (1956)

Article1 July 1956THE EARLY DIAGNOSIS AND NATURAL HISTORY OF CHRONIC LYMPHATIC LEUKEMIAC. HOUGIE, M.B., B.S., L.R.C.P., M.R.C.S. (Eng.)C. HOUGIE, M.B., B.S., L.R.C.P., M.R.C.S. (Eng.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-1-39 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is well known that chronic lymphatic leukemia may run a long and practically asymptomatic course. The classic picture of splenomegaly, lymphadenopathy, anemia and a very high leukocyte count is probably only a late phase in the natural history, but it is this stage of the disease that has received the most study. The pathologic processes at the inception of a disease are always the most interesting, yet there are few clinicopathologic data on chronic lymphatic leukemia in its early stages. This is probably because the opportunity to observe the course of leukemia before the disease has caused symptoms is...Bibliography1. Beresford OD: Chronic lymphatic leukaemia associated with malignant disease, Brit. J. Cancer 6: 339-344, 1952. CrossrefMedlineGoogle Scholar2. Dacie JV: Practical hematology, 1951, Chemical Publishing Co., Inc., Brooklyn, N. Y., pp. 78-80. Google Scholar3. Forkner CE: Leukemia and allied disorders, 1938, The Macmillan Company, New York, p. 139. Google Scholar4. Hynes M: Aleukemic leukemia, Quart. J. Med. 9 NS: 177-192, 1940. Google Scholar5. Kristenson A: A new method for direct counting of so-called blood platelets in man, Acta med. Scandinav. 57: 301-312, 1922. CrossrefGoogle Scholar6. Lempert H: A modified technique for the enumeration of blood platelets, Lancet 1: 151, 1935. CrossrefGoogle Scholar7. McGavran CW: Lymphatic leukemia of twenty-five years' duration, Ann. Int. Med. 12: 396-402, 1938. LinkGoogle Scholar8. MorrisonFeldmanSamwick MFAA: Carcinoma and leukemia: report of two cases with combined lesions: review of literature, Ann. Int. Med. 20: 75-84, 1944. LinkGoogle Scholar9. Richter MN: Leucemia, in Downey, H.: Handbook of hematology, 1938, Vol. 4, Paul B. Hoeber, Inc., New York, p. 2921. Google Scholar10. Scott RB: Place of radiotherapy in treatment of chronic lymphoid leukemia, J. Fac. Radiol., London 1: 61-66, 1949. CrossrefGoogle Scholar11. Wintrobe MM: Clinical hematology, 2nd Ed., 1951, Lea and Febiger, Philadelphia, p. 818. Google Scholar12. WintrobeHasenbush MMLL: Chronic leukemia, Arch. Int. Med. 64: 701-718, 1939. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chapel Hill, North Carolina*Received for publication February 3, 1956.From the Department of Pathology, University of North Carolina Medical School, Chapel Hill, North Carolina, and the West London Hospital Medical School.Requests for reprints should be addressed to C. Hougie, M.D., Dept. of Pathology, University of North Carolina School of Medicine, Chapel Hill, N. C.This work was supported in part by a grant from the Dan Mason Research Foundation, West London Hospital Medical School, England.†The author is Instructor in Pathology at the University of North Carolina Medical School. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMarked lymphocytosis suggesting chronic lymphocytic leukemia in three patients with hyposplenismCoexistence of chronic lymphocytic leukemia and Hodgkin's diseaseDie chronische lymphatische LeukämieGaucher's disease associated with chronic lymphocytic leukaemia, gout and carcinomaRegeneration, Hyperplasie und Onkogenese der lymphoretikulären OrganeBIBLIOGRAPHYLymphoma of lung masquerading as sarcoidosisLEUKÆMIA 1 July 1956Volume 45, Issue 1Page: 39-55KeywordsAnemiaNatural history of diseaseSplenomegaly ePublished: 1 December 2008 Issue Published: 1 July 1956 PDF downloadLoading ...