IRON THERAPY IN CHRONICALLY FATIGUED, NONANEMIC WOMEN: A DOUBLE-BLIND STUDY
Authors: E BEUTLER, S E LARSH, C W GURNEY
Journal: Annals of Internal Medicine (1960)

Article1 February 1960IRON THERAPY IN CHRONICALLY FATIGUED, NONANEMIC WOMEN: A DOUBLE-BLIND STUDYE. BEUTLER, M.D., S. E. LARSH, M.D., C. W. GURNEY, M.D.E. BEUTLER, M.D., S. E. LARSH, M.D., C. W. GURNEY, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-2-378 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe chronically fatigued patient represents one of the most common and most challenging clinical problems faced by the physician today. Sometimes, clear-cut abnormalities revealed by the physical or laboratory examination point to an explanation of the patient's symptoms. More often, however, no clue to the nature of the patient's disorder is found. Consequently, the origin of the complaint is frequently relegated to the vague area of the psychoneuroses, sometimes unfortunately, in the absence of any positive evidence of emotional disturbance.Recent observations of Jasinski and co-workers1-5have drawn our attention to the possibility that some chronically fatigued women may be...Bibliography1. Jasinski B: Über Pathogenesis and Therapie der nicht-anämischen und leicht anämischen Eisenmangelzustande, Schweiz. med. Wchnschr. 79: 1255-1258, 1949. MedlineGoogle Scholar2. Jasinski B: Die Bedeutung der Eisenresorptionsversuche für die Diagnose und Differentialdiagnose der Eisenmangelanämien insbesondere für die Erkennung der Eisenmangelzustande ohne Anämie, Schweiz. med. Wchnschr. 79: 291-293, 1949. MedlineGoogle Scholar3. Jasinski B: Zur Frage der nicht- und der leicht anämischen Eisenmangelkrankheit, Praxis 38: 811-816, 1950. Google Scholar4. JasinskiDiener BE: Zur Frage der Häufigkeit des larvierten Eisenmangels bei Frauen, insbesondere bei graviden und bei wochnerinnen, Gynaecologia 133: 293-304, 1952. MedlineGoogle Scholar5. JasinskiRoth BO: Larvierte Eisenmangelkrankheit, 1954, Benno Schwabe and Co., Basel. Google Scholar6. BecquerelRodier LA: Gaz. med. Paris 12: 751, 1844, cited by Berde, B., Hollander, L., Undritz, E., and Zehnder, K.: Serumeisenstudien bei Blutspendern, Schweiz. med. Wchnschr. 85: Nr. 38/39, 936, (Sept. 20) 1955, by Undritz, E., in discussion. Google Scholar7. Laache S: Die Anämie, 1883, Malling, Christiania, Norway. Google Scholar8. Sahli H: Lehrbuch der klinischen Untersuchungsmethoden, 1908, Franz Deuticke, Leipzig and Vienna, p. 933. Google Scholar9. Dubnikoff D: Klinische Untersuchungen über Eisenwirkung und "larvierte Chlorose." Ein Beitrag zur Lehre von der Chlorose, Inaugural Dissertation, 1908, Stampfli et Cie., Bern, Switzerland. Google Scholar10. Naegeli O: Blutkrankheiten und Blutdiagnostik (Lehrbuch der morphologischen Hämatologie), 1908, Verlag Von Veit and Company, Leipzig, p. 237. CrossrefGoogle Scholar11. Morawitz P: Untersuchungen über Chlorose, München. med. Wchnschr. 57: 1425-1430, 1910. Google Scholar12. Beifeld AF: Chlorosis, M. Clin. Chicago 2: 963-989, 1916-1917. Google Scholar13. Waldenström J: Iron and epithelium. Some clinical observations, Acta med. Scandinav. Suppl. 90: 380-397, 1938. Google Scholar14. Rustung E: Studies on serum iron, Acta dermat.-venereol. Suppl. 21 (Oslo) 29: 1-140, 1949. Google Scholar15. Thedering F: Diagnose und Behandlung des larvierten Eisenmangels, Med. Klin. 50: 1463-1467, 1950. Über die Steuerung der Eisenresorption, Medizinische 38: 1224-1228 (Sept. 19), 1953. Google Scholar16. GoldeckRemyLabhard HDH: Eisenmangel und Schwangerschaft, Deutsche med. Wchnschr. 79: 211-212, 1954. CrossrefMedlineGoogle Scholar17. Undritz E: Die larvierte Chlorose von Sahli, Schweiz. Naturforsch. Gesells. Verhandl. 136: 169-170, 1956. Google Scholar18. VerloopMeeuwissenBlokhuis MCJEEW: Comparison of the "iron absorption test" with the determination of the iron-binding capacity of serum in the diagnosis of iron deficiency, Brit. J. Haemat. 4: 70-81, 1958. CrossrefMedlineGoogle Scholar19. Beutler E: The clinical evaluation of iron stores, New England J. Med. 256: 692-697, 1957. CrossrefMedlineGoogle Scholar20. BeutlerRobsonButtenwieser EME: A comparison of the plasma iron, iron-binding capacity, sternal marrow iron and other methods in the clinical evaluation of iron stores, Ann. Int. Med. 48: 60-82, 1958. LinkGoogle Scholar21. Beutler E: Iron enzymes in iron deficiency. I. Cytochrome C, Am. J. M. Sc. 234: 517-527, 1957. CrossrefMedlineGoogle Scholar22. BeutlerBlaisdell ERK: Iron enzymes in iron deficiency. III. Catalase in rat red cells and liver with some further observations on cytochrome C, J. Lab. and Clin. Med. 52: 694-699, 1958. MedlineGoogle Scholar23. Beutler E: Iron enzymes in iron deficiency. IV. Cytochrome oxidase in rat kidney and heart, Acta haemat. 21: 371-377, 1959. CrossrefMedlineGoogle Scholar24. Beutler E: Iron enzymes in iron deficiency. V. Succinic dehydrogenase in rat liver, kidney and heart, Blood, in press. Google Scholar25. Beutler E: Iron enzymes in iron deficiency. VI. Aconitase activity and citrate metabolism, J. Clin. Investigation 38: 1605-1616, 1959. CrossrefMedlineGoogle Scholar26. GublerCartwrightWintrobe CJGEMM: Studies on copper metabolism. XX. Enzyme activities and iron metabolism in copper and iron deficiencies, J. Biol. Chem. 224: 533-546, 1957. CrossrefMedlineGoogle Scholar27. KampschmidtAdamsGoodwin RFMEWL: Cytochrome C concentration in the tissues of normal and tumor-bearing rats, Arch. Biochem. and Biophys. 82: 42-49, 1959. CrossrefMedlineGoogle Scholar28. BeutlerBlaisdell ERK: Iron enzymes in iron deficiency. II. Catalase in human erythrocytes, J. Clin. Investigation 37: 833-835, 1958. CrossrefMedlineGoogle Scholar29. Boddington MM: Changes in buccal cells in the anaemias, J. Clin. Path. 12: 222-227, 1959. CrossrefMedlineGoogle Scholar30. Jacobs A: Oral cornification in anaemic patients, J. Clin. Path. 12: 234-237, 1959. CrossrefGoogle Scholar31. HussainPatwardban RVN: Iron content of thermal-sweat in iron-deficiency anemia, Lancet 1: 1073-1074 (May 23) 1959. CrossrefMedlineGoogle Scholar32. BarkanWalker GBS: Determination of serum iron and pseudohemoglobin iron with O-phenanthroline, J. Biol. Chem. 135: 37-42, 1940. CrossrefGoogle Scholar33. RathFinch CGCA: Chemical, clinical, and immunological studies on the products of human plasma fractionation. XXXVIII. Serum iron transport. Measurement of iron-binding capacity of serum in man, J. Clin. Investigation 28: 79-85, 1949. CrossrefGoogle Scholar34. KaplanZuelzerMouriquand EWWC: Sideroblasts. A study of stainable nonhemoglobin iron in marrow normoblasts, Blood 9: 203-213, 1954. CrossrefMedlineGoogle Scholar35. Fisher RA: The exact treatment of 2 X 2 tables, in Statistical methods for research workers, 12th Ed., 1954, Hafner Publishing Co., Inc., New York, pp. 96-97. Google Scholar36. Heilmeyer L: Zur Frage der Reizwirkung des Eisens, Deutsche med. Wchnschr. 75: 1086, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication August 7, 1959.From the Argonne Cancer Research Hospital, operated by The University of Chicago for the United States Atomic Energy Commission, and the Department of Medicine, The University of Chicago, Chicago, Illinois.Requests for reprints should be addressed to Ernest Beutler, M. D., Chairman, Department of Medicine, City of Hope Medical Center, Duarte, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byInfluence of iron supplementation on fatigue, mood states and sweating profiles of healthy non-anemic athletes during a training exercise: A double-blind, randomized, placebo-controlled, parallel-group studyIron, neuro‐bioavailability and depressionIron status and self‐reported fatigue in blood donorsThe effects of intravenous iron supplementation on fatigue and general health in non-anemic blood donors with iron deficiency: a randomized placebo-controlled superiority trialThe benefits of iron supplementation following blood donation vary with baseline iron statusEndurance Anemia, Relevance to TriathlonDiagnosis, treatment, and work impact of iron deficiency anemia in a Portuguese urban communityImpact of body iron store on sexual function: a comprehensive review and pilot cohort study in midlife womenAssociation of blood donation with iron deficiency among adolescent and adult females in the United States: a nationally representative studyDysregulated iron metabolism in polycythemia vera: etiology and consequencesIron deficiency without anaemia is a potential cause of fatigue: meta-analyses of randomised controlled trials and cross-sectional studiesPutting donor health first in strategies to mitigate donor iron deficiencyTo Fe, or not to FeEvidence of relative iron deficiency in platelet- and plasma-pheresis donors correlates with donation frequencyEisenmangel, Müdigkeit und Restless-Legs-SyndromNon-anaemic iron deficiency - a disease looking for recognition of diagnosis: a systematic reviewA randomized, blinded, placebo-controlled trial of education and iron supplementation for mitigation of iron deficiency in regular blood donorsRecent Advances in Iron MetabolismThe strategies to reduce iron deficiency in blood donors randomized trial: design, enrolment and early retentionCarence en fer et troubles digestifsConcerning iron balance in blood donorsIron Deficiency Without Anemia Is Associated with Anger and Fatigue in Young Japanese WomenEvaluation of a Single Dose of Ferric Carboxymaltose in Fatigued, Iron-Deficient Women – PREFER a Randomized, Placebo-Controlled StudyInvestigation to Study the Efficacy of Ferrum Phos 3x Alone and Along with Homeopathic Constitutional Medicines on Hemoglobin Level in Adolescence GirlsLow hemoglobin deferral in blood donorsLower hemoglobin with lower ferritin: It is not just a question of anemiaIron and transfusion medicineIs Iron Deficiency in the Absence of Anemia Associated With Fatigue in Inflammatory Bowel Disease?Low iron storage and mild anemia in postural tachycardia syndrome in adolescentsOne iron pill a day keeps fatigue away?Iron Nutrition and Premenopausal Women: Effects of Poor Iron Status on Physical and Neuropsychological PerformanceLow iron storage in children with tilt positive neurally mediated syncopeIron deficiency without anaemia: Do not wait for the haemoglobin to drop?Supplémentation en fer : indications, limites et modalitésClinical evaluation of iron treatment efficiency among non-anemic but iron-deficient female blood donors: a randomized controlled trialIntravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentrationIroning out fatigueIron Status and Neuropsychological Consequences in Women of Reproductive Age: What Do We Know and Where Are We Headed?,Editorial: the role of intravenous iron in heart failure - beyond anemia correctionDemographic correlates of low hemoglobin deferral among prospective whole blood donorsANAEMIA MANAGEMENT IN CARDIO RENAL DISEASEThe impact of iron supplementation efficiency in female blood donors with a decreased ferritin level and no anaemia. Rationale and design of a randomised controlled trial: a study protocolCognitive and Behavioral Consequences of Iron Deficiency in Women of Reproductive AgeAn increased prevalence of fibromyalgia in iron deficiency anemia and thalassemia minor and associated factorsLow Iron Storage in Children and Adolescents with Neurally Mediated SyncopeNutritional iron deficiency: an evolutionary perspectiveIron depletion by whole-blood donation harms menstruating females: The current whole-blood-collection paradigm needs to be changedHaematological effects of the C282Y HFE mutation in homozygous and heterozygous states among subjects of northern and southern European ancestryIron Deficiency and OverloadHistory of Iron in MedicineSerum concentrations of some metals and steroids in patients with chronic fatigue syndrome with reference to neurological and cognitive abnormalitiesIron Status and Depression in Premenopausal Women: An MMPI StudyIron Status and Non-Specific Symptoms of Female StudentsPredicted Mean Corpuscular Volume as an Indicator of Bone Marrow Iron in Anemic DogsDiagnosis of iron deficiency in dialysis patientsDIAGNOSIS OF IRON DEFICIENCYEFFECT OF IRON SUPPLEMENTATION TO WOMEN WITH IRON DEFICIENCYIron deficiency and iron overloadIron supplementation for menstruating female blood donorsPerspectives in Iron MetabolismIronANÆMIA AFTER PARTIAL GASTRECTOMY: A NEGLECTED CURABLE CONDITIONBIOCHEMICAL AND BEHAVIOURAL ASPECTS OF SIDEROPENIAChapter I: Prevention of iron deficiency with hemoglobin-iron. A review of studies of the absorption of heme and non-heme iron.Iron Deficiency: Behavior and Brain BiochemistryEFFECTS OF IRON DEFICIENCY EXCLUSIVE OF ANAEMIABehavioral and biochemical correlates of iron deficiency. A reviewAnemia in AdolescenceNutrition; Iron Undernutrition in InfancyEvaluation of the clinical importance of anemiaIron Deficiency in Patients with Chronic Obstructive Airways DiseaseIron Deficiency in ChildrenReview: Relationships of copper and molybdenum to iron metabolismIron supplementation of the diet in full-terminfants: A controlled studyDiagnostische Kriterien des prälatenten, latenten und manifesten EisenmangelsCurrent Concepts of Iron Metabolism and the Iron Deficiency AnemiasIron deficiency without anaemia — The M.C.H.C. in screeningANAEMIA IN PREGNANCY IN WESTERN AUSTRALIAAssessing the Functional Significance of AnæmiaSymptoms and circulating haemoglobin levelCytochrome oxidase activity in the gastric mucosa of patients with iron deficiencyTired CellsIron Nutriture of Girls and Women—A Review . II. Iron StoresPETHIDINE IN ACUTE MYOCARDIAL INFARCTIONIRON DEFICIENCY WITHOUT ANÆMIAIron Deficiency without AnæmiaANOTHER AMITRIPTYLINE SIDE-EFFECT?IRON DEFICIENCY WITHOUT ANÆMIASome epidemiological problems of iron deficiency anaemiaA Controlled Trial of Iron Therapy in SideropeniaSideropeniaIncidence of Iron Deficiency, with and without Anaemia, in Women in General PracticeNormalityThe Presymptomatic Diagnosis of AnæmiaThrombocytopenia Associated with Iron Deficiency AnemiaValue of Erythrocyte Protoporphyrin in the Diagnosis of Latent Iron Deficiency (Sideropenia)Cytochrome Oxidase in Latent Iron Deficiency (Sideropenia)IRON AND THE HAEMOGLOBIN LEVEL IN PREGNANCYAnnotationsVARIATIONS IN SERUM-IRON IN HEALTHY WOMENDynamics of iron metabolism in pregnancyIron Deficiency and Iron OverloadIRON DEFICIENCY WITHOUT ANÆMIAPOLYCYTHÆMIA AND IRON DEFICIENCY IN PULMONARY "EMPHYSEMA"Serum Iron and Iron-Binding Capacity in AdolescentsSerum Iron and Iron-Binding Capacity in AdolescentsIntriguing Types of Hypochromic AnemiaUse of the Prussian Blue Reaction in the Differential Diagnosis of AnemiasWARREN D. BOWMAN JR., M.D.Studies in iron metabolismRefractory anemias of pregnancy 1 February 1960Volume 52, Issue 2Page: 378-394KeywordsAnemiaAttentionBlood plasmaEmotionsHemoglobinHospital medicineResearch laboratories ePublished: 1 December 2008 Issue Published: 1 February 1960 PDF downloadLoading ...