tbuckley/cabot-search huggingface dataset:
Abstract 5171: An integrated analysis of copy number alteration and global gene expression reveals potential oncogenes underlying stomach cancer
Authors: Kyoung Song, Ryong Nam Kim, Sinyoung Jeon, Hae I. Kim, Yoon-La Choi, Young Kee Shin
Journal: Cancer Research (2014)

Abstract Although several studies had been carried out to elucidate causative copy number alteration (CNA) underlying stomach carcinogenesis, deeper understanding of CNA accumulations in stomach cancer genome in association with age and histo-pathological subtypes remains still mysterious. Here, we report an integrated analysis of genome-wide copy number alteration and global mRNA expression of 40 stomach cancer tissues from 19 old and 21 young patients using aCGH and microarray. We identified that stomach cancer genomes showed recurrent amplifications at 17q12 (ERBB2 amplicon) and 7q31.1-7q31.31 (MET amplicon), and homozygous deletions at 9p21.3 and 17p12 regions harboring tumor suppressor genes. The most frequent gained regions were 3q26.2 (45%), 7p21.1 (&amp;gt;50%), 7p12.2 (∼50%), 8q21.11-8q21.12 (45%), 8q22.3 (45%), 8q24.21 (45%), 8q24.22 (45%), 8q24.3 (45%), 20q12 (45%) and 20q13.2 (45%). The most frequent deleted regions were 21p11.1 (∼50%), 19p13.2 (45%), 19p13.3 (45%), 4q12 (40%), 3p21.31 (40%) and 1p35.3 (40%). Whereas young stomach cancer genomes showed more frequent gains at 7q21-7q31 than old cancer genomes, old stomach cancer genomes exhibited more recurrent gains at 8q12-8q24 and 1p12-1q42 than young cancer genomes, providing a clue about evolution of CNA accumulation in stomach cancer genome. Hierarchical expression clustering of 506 (in amplified regions) and 60 (in regions showing homozygous deletion) genes across the 40 stomach cancer samples reclassified pathological and histological subtypes based on expression pattern. Our integrated analysis of aCGH and microarray gene expression identified a pool of potential candidate stomach oncogenes and tumor suppressor genes. SiRNA-based interference of genes in MET amplicon and ERBB2 amplicon in stomach cancer cell lines significantly suppressed cell proliferation and migration, suggesting that they could be novel potential oncogenes in stomach cancer. Taken together, this study improves our understanding of stomach cancer genome evolution during CNA accumulation process and provides a new gene set of novel potential oncogenes and tumor suppressor genes that are essential for developing novel diagnostic biomarker and therapeutics for stomach cancer. Citation Format: Kyoung Song, Ryong Nam Kim, Sinyoung Jeon, Hae In Kim, Yoon-La Choi, Young Kee Shin. An integrated analysis of copy number alteration and global gene expression reveals potential oncogenes underlying stomach cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 5171. doi:10.1158/1538-7445.AM2014-5171
Measurement of Delayed Skin-Test Responses
Authors: Joseph E. Sokal
Journal: New England Journal of Medicine (1975)

Measurement of delayed skin-test responses is a basic clinical procedure, originally used for identification of infection with microbial agents. More recently, skin testing with a battery of antigens has had wide application in the evaluation of cellular immune reactivity of patients with malignant neoplasms. Such measurements may provide important prognostic information.1 , 2 It is generally assumed that every physician knows when and how to read a skin test, and this subject has received little investigative or teaching attention in recent years. Unfortunately, the utility of this simple and universally available method of immunologic examination is compromised by substantial variation in measurements . . .
Efficient Bayesian mixed-model analysis increases association power in large cohorts
Authors: Po-Ru Loh, George Tucker, Brendan K Bulik-Sullivan, Bjarni J Vilhjálmsson, Hilary K Finucane, Rany M Salem, Daniel I Chasman, Paul M Ridker, Benjamin M Neale, Bonnie Berger, Nick Patterson, Alkes L Price
Journal: Nature Genetics (2015)
The Pocked Erythrocyte
Authors: Christopher P. Holroyde, Frank A. Oski, Frank H. Gardner
Journal: New England Journal of Medicine (1969)

A study of red-cell surface morphology using interference-contrast microscopy showed striking morphologic differences in premature and term infants, children of various ages and normal adults. In normal adults 2.6 per cent of erythrocytes gave the appearance of having small (0.2 to 0.5 μ) pits or craters on their surface. By contrast, premature and term infants had a mean of 47.2 per cent and 24.3 per cent pitted cells respectively, reaching near adult values by two months of age in term infants and taking somewhat longer in premature infants. An inverse correlation was observed between birth weight and the number of pitted cells. The finding of increased numbers of pitted cells in the neonate may reflect reticuloendothelial or splenic hypofunction since this type of cell has so far been observed with such frequency only in patients without spleens.
A NEW TUBERCULIN
Authors: A. Lundie
Journal: BMJ (1925)

A NEW TUBERCULIN.[MEDICJOB 405 treated, the ma,jolrity withiout ol)erationi, and the total nmortality was 80.5 per cenit.Prior to the initroductioni of tlhe Raiiinmstedt operation in 1918, the operative miiortality at this hospital was 100 per cenit., nlot one sinigle case liaving.recovered after operation.In the following year, wlheni the Raminstedt operation was adopted, it fell to 41 per cenit.after surgical treatment, whilst in 1923 for 55 collected eases the operative mortality was 29 pei cent.Dutrinig the past twelve moniths -we lhave operated on 16 cases, witlh 5 deaths.This gives a death rate of approximately 30 per cent.Death occulrred in 2 cases witllin twenty-four hLours of operationi, anid was due to post- opelrative collapse in weakly and debilitated infants.In 3 cases it occurred four, seven, and twelvoe days later, anid apleared to be due to gastro-initestinal disturbances and iniability of the infanit to assimilate its niourislhmnenit.In cases with a lonig history it is not unusual to find the intestines smnall and slhrulnkeni when examined post mortem, anid it appears that death is duce to their atroplhy from disuse and their failure to recover their digestive functioni.The average age in these cases wras 7 wz-eeks, anid the dura- tioit of symiiptomis twenty-onie days.The conidition most
Association Among Individual Deprivation, Glycemic Control, and Diabetes Complications
Authors: Hélène Bihan, Silvana Laurent, Catherine Sass, Gérard Nguyen, Caroline Huot, Jean Jacques Moulin, René Guegen, Philippe Le Toumelin, Hervé Le Clésiau, Emilio La Rosa, Gérard Reach, Régis Cohen
Journal: Diabetes Care (2005)

OBJECTIVE—Previous studies have related poor glycemic control and/or some diabetes complications to low socioeconomic status. Some aspects of socioeconomic status have not been assessed in these studies. In the present study, we used an individual index of deprivation, the Evaluation de la Précarité et des Inégalités de santé dans les Centres d’Examens de Santé (Evaluation of Precarity and Inequalities in Health Examination Centers [EPICES]) score, to determine the relationship among glycemic control, diabetes complications, and individual conditions of deprivation. RESEARCH DESIGN AND METHODS—We conducted a cross-sectional prevalence study in 135 consecutive diabetic patients (age 59.41 ± 13.2 years [mean ± SD]) admitted in the hospitalization unit of a French endocrine department. Individual deprivation was assessed by the EPICES score, calculated from 11 socioeconomic questions. Glycemic control, lipid levels, blood pressure, retinopathy, neuropathy, and nephropathy were assessed. RESULTS—HbA1c level was significantly correlated with the EPICES score (r = 0.366, P &amp;lt; 0.001). The more deprived patients were more likely than the less deprived patients to have poor glycemic control (β = 1.984 [SE 0.477], P &amp;lt; 0.001), neuropathy (odds ratio 2.39 [95% CI 1.05–5.43], P = 0.037), retinopathy (3.66 [1.39–9.64], P = 0.009), and being less often admitted for 1-day hospitalization (0.32 [0.14–0.74], P = 0.008). No significant relationship was observed with either nephropathy or cardiovascular risk factors. CONCLUSIONS—Deprivation status is associated with poor metabolic control and more frequent microvascular complications, i.e., retinopathy and neuropathy. The medical and economic burden of deprived patients is high.
Morning Surge in Blood Pressure
Authors: Norman M. Kaplan
Journal: Circulation (2003)

ome days it just doesn't pay to get out of bed.As long recognized, there is an increased risk for heart attack, stroke, and sudden death in the first few hours of the morning. 1,2In this issue of Circulation, Kario and colleagues have shown that, as for strokes, this risk is associated with a morning surge in blood pressure. 3Among the 519 elderly hypertensives in this study, the risk of stroke identified by brain MRI was 2.7-fold greater among the 55 who were in the top decile of the degree of morning surge of systolic blood pressure compared with the remaining subjects.
The management of alcoholic liver disease
Authors: Stephen F Stewart, Christopher P Day
Journal: Journal of Hepatology (2003)

Alcoholic liver disease (ALD) is the commonest cause of cirrhosis in the Western world, currently one of the ten most common causes of death [1]. Deaths from cirrhosis rose with per capita alcohol consumption from the 1950s to the 1970s in many Western countries, but have since declined out of proportion to the minor decrease in intake [2]. While this may be partly explained by changes in the age and ethnic background of these populations, it also seems likely to reflect advances in the management of patients with both alcohol and non-alcohol-related advanced liver disease. Clearly, any improvement in the management of the general complications of liver disease will have a beneficial effect on the management of patients with advanced ALD. However, this review principally focuses on treatment strategies that have been specifically directed at mechanisms involved in the pathogenesis of alcohol-related liver injury and considers their current and future role in the management of patients with the various stages of ALD.
A Population-Based Study of the Clinical Expression of the Hemochromatosis Gene
Authors: John K. Olynyk, Digby J. Cullen, Sina Aquilia, Enrico Rossi, Lesa Summerville, Lawrie W. Powell
Journal: New England Journal of Medicine (1999)

Hereditary hemochromatosis is associated with homozygosity for the C282Y mutation in the hemochromatosis (HFE) gene on chromosome 6, elevated serum transferrin saturation, and excess iron deposits throughout the body. To assess the prevalence and clinical expression of the HFE gene, we conducted a population-based study in Busselton, Australia. In 1994, we obtained blood samples for the determination of serum transferrin saturation and ferritin levels and the presence or absence of the C282Y mutation and the H63D mutation (which may contribute to increased hepatic iron levels) in 3011 unrelated white adults. We evaluated all subjects who had persistently elevated transferrin-saturation values (45 percent or higher) or were homozygous for the C282Y mutation. We recommended liver biopsy for subjects with serum ferritin levels of 300 ng per milliliter or higher. The subjects were followed for up to four years.
Patterns of disease: diabetes mellitus and the rest
Authors: R. E LaPorte
Journal: BMJ (1995)

fees seem to have reduced attendance at rural health facilities in Ghana9 and treatment for sexually transmitted diseases in Kenya.'"The World Bank itself acknowledges a problem when user fees reach 1% of annual household income."The South pays back debt at enormous social cost, and this contributes to the dismantling of its health and educational systems.By 1990 over $50bn a year was pouring from indebted developing nations to their creditors.'2If the summit is serious in its desire to relieve poverty, says the Group of 77 nations, the collective voice of the South, then African debt must be cancelled and the debts of other poor countries reduced by a target date."3The draft declaration of the conference also calls for urgent consideration to be given to the relief of multilateral debt (owed to the World Bank and International Monetary Fund).UN conferences are often the lowest common denominator for international action.As doctors, how can we promote the summit's undoubted good intentions?Firstly, we can increase public awareness of the urgent need to reduce poverty, both nationally and internationally, emphasising its deleterious effect on health.Health issues will not receive sufficient attention at the conference and need to be high- lighted in future.Through universities and research insti- tutions, understanding of the causes of poverty and the effectiveness of antipoverty campaigns can be improved.Finally, integration of the results of social science and health research into economic decision making should be encouraged so that balancing budgets does not unbalance the lives of people.
A novel missense mutation (Gln306His) in exon 7 of the ED1 gene causing anhidrotic ectodermal dysplasia with prominent milia-like facial sebaceous papules
Authors: M.M.L. Hsu, S.C. Chao, A.C.H. Lu
Journal: British Journal of Dermatology (2003)

Journal Article A novel missense mutation (Gln306His) in exon 7 of the ED1 gene causing anhidrotic ectodermal dysplasia with prominent milia‐like facial sebaceous papules Get access M.M.L. Hsu, M.M.L. Hsu Department of Dermatology, College of Medicine, National Cheng‐Kung University Hospital, 138 Sheng‐Li Road, 704 Tainan, Taiwan E‐mail: a441224@mail.ncku.edu.tw Search for other works by this author on: Oxford Academic Google Scholar S.C. Chao, S.C. Chao Department of Dermatology, College of Medicine, National Cheng‐Kung University Hospital, 138 Sheng‐Li Road, 704 Tainan, Taiwan E‐mail: a441224@mail.ncku.edu.tw Search for other works by this author on: Oxford Academic Google Scholar A.C.H. Lu A.C.H. Lu Department of Dermatology, College of Medicine, National Cheng‐Kung University Hospital, 138 Sheng‐Li Road, 704 Tainan, Taiwan E‐mail: a441224@mail.ncku.edu.tw Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 149, Issue 2, 1 August 2003, Pages 443–445, https://doi.org/10.1046/j.1365-2133.2003.05480.x Published: 01 August 2003
Excessive β-Blockade With Timolol Eye Drops
Authors: Gary D. Novack
Journal: JAMA (1996)

To the Editor.  —The problem of cardiopulmonary β-blockade following glaucoma pharmacotherapy with ophthalmic administration of β-adrenoceptor antagonists is a major worry. Although the conclusions of Dr Edeki and colleagues 1 regarding P-450 CYP2D6 phenotype and susceptibility to this undesirable effect are intriguing, there are several concerns about their methods and extrapolation to the clinical situation.  It appears that drugs administered by the nasal route, used by the authors to minimize variability, may be more bioavailable to the systemic circulation than true ocular drug instillation as is used therapeutically. The mean plasma levels of timolol observed within the first hour in their study were approximately 2 to 4 ng/mL, and are higher than levels reported with ocular instillation, approximately 1 ng/mL. 2,3 The theoretical route of ophthalmic timolol into the systemic circulation is via the nasolacrimal duct, with absorption through the nasal mucosa. In turn, the venous system in the nasal
Investigation of an interleukin-6 receptor gene polymorphism (rs2228145) as a predictor of cardiovascular mortality in inflammatory polyarthritis: results from the Norfolk Arthritis Register: Table 1
Authors: Ibrahim Ibrahim, Kate McAllister, Darren Plant, Deborah Symmons, Tarnya Marshall, Anne Barton, Stephen Eyre
Journal: Annals of the Rheumatic Diseases (2013)

In patients with rheumatoid arthritis (RA), chronic inflammation on a background of established cardiovascular disease (CVD) risk factors is thought to contribute to atherosclerosis, resulting in the observed increased mortality from CVD.1 

Recent studies suggest a role for interleukin-6 receptor (IL6R) in both CVD2 ,3 and RA.4 A functional, non-synonymous genetic variant found within the IL6R gene (rs2228145) conferring an amino acid change (Asp358Ala) influential in determining levels of soluble IL6R5 has been convincingly associated with both CVD occurrence2 ,3 and RA.4 This amino acid change within the IL6R gene has a similar effect to the RA therapy, tocilizumab, which targets the IL6R pathway, leading to an increase in IL6R and soluble IL6 levels, as well as a decrease in C-reactive protein (CRP) levels. Although unlikely to be causal in disease,6 CRP levels …
Time to Act on Drug Safety
Authors: Thomas J. Moore, Bruce M. Psaty, Curt D. Furberg
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cigarette Smoking and Prevalence of Microangiopathy in Juvenile-Onset Insulin-dependent Diabetes Mellitus
Authors: Jens Sandahl Christiansen
Journal: Diabetes Care (1978)

In order to evaluate a possible relation between cigarette smoking and prevalence of diabetic microangiopathy, a series of 180 consecutive patients suffering from insulin-dependent juvenile-onset diabetes mellitus with different durations of disease (60 patients each with diabetes for 10 to 19 years, 20 to 29 years, and 30 to 39 years, respectively) were examined for clinical signs of retinopathy, nephropathy, and peripheral neuropathy. The results were compared with the patients' previous and actual smoking habits. Cigarette smoking was defined as daily smoking of at least ten cigarettes for one year or more. Smoking habits of the total diabetic sample were not significantly different from those of a nondiabetic control sample. However, a decline in the number of cigarette smokers and a rising number of ex-smokers were noted with increasing duration of diabetes. In comparing smokers and nonsmokers, no difference was found in the prevalence of peripheral neuropathy, background retinopathy, and proliferative retinopathy. However, the prevalence of nephropathy (persistent proteinuria) was significantly higher (p less than 0.05) among these patients who were or had been cigarette smokers. Thus, cigarette smoking might be considered a risk factor for the development of diabetic nephropathy.
APOLIPOPROTEIN A1 PREDICTS FUTURE DEATH AND MYOCARDIAL INFARCTION IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY
Authors: Heidi Thomas May, Krishnaji R. Kulkarni, Benjamin D. Horne, Jeffrey L. Anderson, Tami L. Bair, Chrissa P. Mower, John F. Carlquist, Joseph B. Muhlestein
Journal: Journal of the American College of Cardiology (2010)
An Experience in Teaching the Patient-Doctor Relationship to First-year Medical Students.
Authors: Seymour Pollack
Journal: Annals of Internal Medicine (1964)

s1 February 1964An Experience in Teaching the Patient-Doctor Relationship to First-year Medical Students.Seymour Pollack, M.D. (Associate)Seymour Pollack, M.D. (Associate)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-2-323_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years there has been renewed interest in the concept of the "patient as a person" both by the patient population emphasizing the breach of this concept in practice and by the medical profession stressing the need to develop and observe better doctor-patient relationships. This relationship, erroneously characterized as "the art of medicine" and "bedside manner," has largely been transmitted to the medical student by clinical preceptorship during his third and fourth years of medical school education.Questions can properly be raised as to whether the attitudes and the approach implicit in the doctor-patient relationship can be taught at... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Seymour Pollack, M.D. (Associate) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1964Volume 60, Issue 2_Part_1Page: 323-323KeywordsMedical education ePublished: 1 December 2008 Issue Published: 1 February 1964 PDF downloadLoading ...
Virological response and safety outcomes in therapy–naïve patients treated for chronic hepatitis C with taribavirin or ribavirin in combination with pegylated interferon alfa-2a: A randomized, phase 2 study
Authors: Robert G. Gish, Sanjeev Arora, K. Rajender Reddy, David R. Nelson, Christopher O’Brien, Yi Xu, Brian Murphy
Journal: Journal of Hepatology (2007)
Precautionary Note on the Use of the Intestinal-Biopsy Capsule in Infants and Emaciated Children
Authors: John C. Partin, William K. Schubert
Journal: New England Journal of Medicine (1966)

FURTHER experience at 2 institutions suggests that there is a distinct hazard of intestinal perforation from the use of the standard-model, pediatric-size Crosby-Kugler intestinal-biopsy capsule.1 , 2 Previous reports3 , 4 have emphasized the safety of this instrument but they have included few infants and children under three years of age and have not adequately defined the risk involved in that group. Although we have found the instrument eminently satisfactory for obtaining jejunal biopsies in children above the age and weight limits defined here, we have produced intestinal perforations in 6 patients whose ages were less than twenty-four months or whose weight was less . . .
What Is Adequate and Appropriate Pain Treatment?
Authors: Louis Jacobson
Journal: JAMA (1996)

To the Editor.  —We disagree with Dr Hill's 1 assertion that  of pain... must be the standard for success. Although appealing in its simplicity and apparent advocacy for patients, it does not apply to chronic nonmalignant pain.  Hill intimates that with opioid treatment, pain relief is a realistic goal. We agree with that goal for acute conditions and applaud efforts to better manage cancer pain, but disagree when he extrapolates from cancer to chronic pain. Chronic pain differs from acute and cancer pain as being a noncurable, lifelong condition. 2 The overriding mandate in medicine is to do no harm. Efforts to relieve chronic pain risk harm by fostering reliance on the health care system, eroding self-efficacy, and endowing the provider with the solutions. Many patients seek relief from a system that has exhausted its treatment options. Patient report of adequate pain relief as the sine qua non for
EVIDENCE FOR PROTECTION BY BREAST-FEEDING AGAINST INFANT DEATHS FROM INFECTIOUS DISEASES IN BRAZIL
Authors: CesarG. Victora, J.Patrick Vaughan, Cintia Lombardi, SandraM.C. Fuchs, LucianaP. Gigante, PeterG. Smith, LeticiaC. Nobre, AnaMariaB. Teixeira, LeilaB. Moreira, FernandoC. Barros
Journal: The Lancet (1987)