Effects of Blood Pressure Reduction in Mild Hypertension
Authors: Johan Sundström, Bruce Neal
Journal: Annals of Internal Medicine (2015)

Letters7 July 2015Effects of Blood Pressure Reduction in Mild HypertensionJohan Sundström, MD, PhD and Bruce Neal, MBChB, PhDJohan Sundström, MD, PhDFrom The George Institute for Global Health, Sydney University, Sydney, Australia. and Bruce Neal, MBChB, PhDFrom The George Institute for Global Health, Sydney University, Sydney, Australia.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5103-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:In Dr. Martin's opinion, mixing apples and oranges serves neither fruit well. Although some share his taste, many like fruit salad. Our view, objectively supported (1), is that apples and oranges have far more commonalities than differences.As Dr. Martin points out, our review differs from a previous one (2) in that it includes many persons with diabetes. Whereas Dr. Martin sees the presence or absence of diabetes as a good reason not to estimate summary effects for all, we disagree.Our rationale for combining participants with and without diabetes is firmly evidence-based. Prior large overviews show quite ...References1. Barone JE. Comparing apples and oranges: a randomised prospective study. BMJ. 2000;321:1569-70. [PMID: 11124178] CrossrefMedlineGoogle Scholar2. Diao D, Wright JM, Cundiff DK, Gueyffier F. Pharmacotherapy for mild hypertension. Cochrane Database Syst Rev. 2012;8:CD006742. [PMID: 22895954] doi:10.1002/14651858.CD006742.pub2 CrossrefMedlineGoogle Scholar3. Turnbull F, Neal B, Algert C, Chalmers J, Chapman N, Cutler J, et al; Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of different blood pressure-lowering regimens on major cardiovascular events in individuals with and without diabetes mellitus: results of prospectively designed overviews of randomized trials. Arch Intern Med. 2005;165:1410-9. [PMID: 15983291] CrossrefMedlineGoogle Scholar4. Sundström J, Arima H, Woodward M, Jackson R, Karmali K, Lloyd-Jones D, et al; Blood Pressure Lowering Treatment Trialists' Collaboration. Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data. Lancet. 2014;384:591-8. [PMID: 25131978] doi:10.1016/S0140-6736(14)61212-5 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Johan Sundström, MD, PhD; Bruce Neal, MBChB, PhDAffiliations: From The George Institute for Global Health, Sydney University, Sydney, Australia.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-0773. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of Blood Pressure Reduction in Mild Hypertension Johan Sundström , Hisatomi Arima , Rod Jackson , Fiona Turnbull , Kazem Rahimi , John Chalmers , Mark Woodward , and Bruce Neal , on behalf of the Blood Pressure Lowering Treatment Trialists' Collaboration* Effects of Blood Pressure Reduction in Mild Hypertension Stephen A. Martin Metrics Cited by2018 Korean Society of Hypertension Guidelines for the management of hypertension: part II-diagnosis and treatment of hypertensionReduction in sympathetic tone in patients with obstructive sleep apnoea: is fixed CPAP more effective than APAP? A randomised, parallel trial protocolMortality reduction by post-dilution online-haemodiafiltration: a cause-specific analysis 7 July 2015Volume 163, Issue 1 Page: 67-68 Keywords Blood Blood pressure Cardiovascular diseases Disclosure Hypertension Primary hypertension Relative risk Taste ePublished: 7 July 2015 Issue Published: 7 July 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...