METABOLISM STUDIES IN MYASTHENIA GRAVIS BEFORE AND DURING THE ADMINISTRATION OF GLYCINE
Authors: Mildred Adams, Marschelle H. Power, Walter M. Boothby
Journal: Annals of Internal Medicine (1936)

Article1 April 1936METABOLISM STUDIES IN MYASTHENIA GRAVIS BEFORE AND DURING THE ADMINISTRATION OF GLYCINEMILDRED ADAMS, Ph.D., MARSCHELLE H. POWER, Ph.D., WALTER M. BOOTHBY, M.D., F.A.C.P.MILDRED ADAMS, Ph.D.Search for more papers by this author, MARSCHELLE H. POWER, Ph.D.Search for more papers by this author, WALTER M. BOOTHBY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-10-1330 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSeveral attempts have been made to discover specific metabolic abnormalities in subjects with myasthenia gravis. The results in general have been contradictory and therefore inconclusive. The therapeutic value of glycine in this disease has caused a renewed interest in such studies, although the majority of the more recent investigations have dealt chiefly with the effect of glycine on the excretion of creatinine and creatine.This investigation was undertaken, accordingly, to gain more complete information concerning the metabolism of patients with myasthenia gravis both before and during the administration of glycine. Complete studies in which the food, urine, and feces have...Bibliography1. ADAMSPOWERBOOTHBY MMHWM: Chemical studies in myasthenia gravis, ANN. INT. MED., 1936, ix, 823-833. Google Scholar2. ADAMSPOWERBOOTHBY MMHWM: Influence of glycine on excretion of creatine and creatinine, Am. Jr. Physiol., 1935, cxi, 596-610. CrossrefGoogle Scholar3. BARBERKOLTHOFF HHIM: A specific reagent for the rapid gravimetric determination of sodium, Jr. Am. Chem. Soc., 1928, l, 1625-1631. CrossrefGoogle Scholar4. BUTLERTUTHILL AME: An application of the uranyl zinc acetate method for determination of sodium in biological material, Jr. Biol. Chem., 1931, xciii, 171-180. CrossrefGoogle Scholar5. FISKESUBBAROW CHY: Colorimetric determination of phosphorus, Jr. Biol. Chem., 1925, lxvi, 375-400. CrossrefGoogle Scholar6. FOLIN O: On the determination of creatinine and creatine in urine, Jr. Biol. Chem., 1914, xvii, 469-473. CrossrefGoogle Scholar7. FOLIN O: Colorimetric determination of amino-acid nitrogen in normal urine, Jr. Biol. Chem., 1922, li, 393-394. CrossrefGoogle Scholar8. FOLINWU OH: Revised colorimetric method for determination of uric acid in urine, Jr. Biol. Chem., 1919, xxxviii, 459-460. CrossrefGoogle Scholar9. FOLINMARENZI OAD: The preparation of uric acid reagent completely free from phenol reagent, Jr. Biol. Chem., 1929, lxxxiii, 109-113. CrossrefGoogle Scholar10. HUBBARD RS: Determination of inorganic sulfate in serum, Jr. Biol. Chem., 1930, lxxxviii, 663-668. CrossrefGoogle Scholar11. KOCH FC: Modified Van Slyke amino nitrogen apparatus, Jr. Biol. Chem., 1929, lxxxiv, 601-603. CrossrefGoogle Scholar12. LAURENTWALTHER LPWW: Influence of large doses of potassium chloride on myasthenia gravis, Lancet, 1935, i, 1434-1435. CrossrefGoogle Scholar13. ROSSENBECK H: Zur Frage der Veraschung von biologischem Material, Biochem. Ztschr., 1929, ccviii, 428-442. Google Scholar14. SHERMAN HC: Methods of organic analysis, 1920, Macmillan Company, New York, pp. 301-303. Google Scholar15. TISDALLKRAMER FFB: Methods for direct quantitative determination of sodium, potassium, calcium and magnesium in urine and stools, Jr. Biol. Chem., 1921, xlviii, 1-12. Google Scholar16. VAN SLYKE DD: Improved methods in the gasometric determination of free and conjugated amino-acid nitrogen in the urine, Jr. Biol. Chem., 1913, xvi, 125-134. CrossrefGoogle Scholar17. VAN SLYKE DD: Determination of urea by gasometric measurement of carbon dioxide formed by the action of urease, Jr. Biol. Chem., 1927, lxxiii, 695-723. CrossrefGoogle Scholar18. VAN SLYKECULLEN DDGE: A permanent preparation of urease, and its use in the determination of urea, Jr. Biol. Chem., 1914, xix, 211-228. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Submitted for publication December 9, 1936. From the Mayo Clinic, Rochester, Minn.†The significance of these symbols is evident in the table. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Acetylcholin-Theorie der MyasthenieCreatinuria in Patients with palpable muscle affections (Myosis) 1 April 1936Volume 9, Issue 10Page: 1330-1337KeywordsCreatineCreatinineExcretionFoodGlycineMyasthenia gravisUrine ePublished: 1 December 2008 Issue Published: 1 April 1936 PDF downloadLoading ...