THE IMMUNOLOGIC ASPECTS OF ALLERGIC CONDITIONS
Authors: W C SPAIN
Journal: Annals of Internal Medicine (1953)

Article1 February 1953THE IMMUNOLOGIC ASPECTS OF ALLERGIC CONDITIONSW. C. SPAIN, M.D., F.A.C.P.W. C. SPAIN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-2-188 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne of the prominent and important functions of the living cell, even in its most primitive forms, is its ability to cope with substances of foreign origin with which it has come into contact. Metchnikoff pointed out that unicellular organisms, such as the ameba, and many cells of complex structure, such as the metazoan bodies, employ this facility for nutritional purposes. Some cells of the higher forms of life may retain their ancestral trait of assimilating certain types of foods not ingested by first intention.1The majority of such cells, members of the reticuloendothelial system, aided by components of the...Bibliography1. Frances T: Response of the host to the parasite, in Dubos, R. J.: Bacterial and mycotic infections of man, 1948, J. B. Lippincott, Philadelphia, pp. 90-109. Google Scholar2. Cannon PR: Antibodies and the protein reserve, J. Immunol. 44: 107, 1942. Google Scholar3. CookeVanderVeer RAA: Human sensitization, J. Immunol. 1: 201, 1916. Google Scholar4. SpainCooke WCRA: Studies in specific hypersensitiveness. II. The familial occurrence of hay fever and bronchial asthma, J. Immunol. 9: 521, 1924. Google Scholar5. Adkinson J: The behavior of bronchial asthma as an inherited character, Genetics 5: 363, 1920. CrossrefMedlineGoogle Scholar6. Cooke RA: Immunology of allergy, Am. J. Med. 3: 523, 1947. CrossrefMedlineGoogle Scholar7. Mackenzie GM: In Cecil's Textbook of medicine, 7th Ed., 1947, W. B. Saunders Co., Philadelphia, p. 545. Google Scholar8. Spain WC: Studies in specific hypersensitiveness. VI. Dermatitis venenata, J. Immunol. 7: 179, 1922. Google Scholar9. BlockSteiner-Wourlisch BA: Die willkürliche Erzeugung die Primelüberempfindlichkeit beim Menschen und Ihre Bedeutung für das Idiosynkrasieproblem, Arch. f. Dermat. u. Syph. 152: 283, 1930; quoted by Chase, M.: The allergic state, in Dubos, R. J.: Bacterial and mycotic infections of man, 1948, J. B. Lippincott, Philadelphia, p. 146. CrossrefGoogle Scholar10. CookeSpain RAWC: Studies in specific hypersensitiveness. XXXVI. A comparative study of antibodies occurring in anaphylaxis, serum disease and in the naturally sensitive man, J. Immunol. 17: 295, 1929. Google Scholar11. PrausnitzKustner CH: Studien über die Uberempfindlichkeit, Centralbl. f. Bakt. 86: 160, 1921. Google Scholar12. KatzCohen GS: Experimental evidence for histamine release in man, J. A. M. A. 117: 782, 1941. CrossrefGoogle Scholar13. SpainStraussNeumann WCMBE: In vitro release of histamine by hypersensitive (allergic) serum in contrast to immune (treated) serum in antigen and normal rabbit blood mixtures, J. Allergy 21: 318, 1950. CrossrefMedlineGoogle Scholar14. Loveless MH: Immunologic studies of pollenosis. I. The presence of two antibodies related to the same pollen antigen in the serum of treated hay fever patients, J. Immunol. 38: 25, 1940. Google Scholar15. Sherman WB: Changes in serological reactions and tissue sensitivity in hay fever patients during the early months of treatment, J. Immunol. 40: 289, 1941. Google Scholar16. Sherman WB: Drug allergy, Am. J. Med. 3: 593, 1947. CrossrefGoogle Scholar17. Brunner M: Active sensitization in human beings, J. Allergy 5: 257, 1934. CrossrefGoogle Scholar18. Chase MW: Allergic inflammation, delayed response, in Dubos, R. J.: Bacterial and mycotic infection of man, 1948, J. B. Lippincott, Philadelphia, pp. 136-148. Google Scholar19. DuBoisSchlossAnderson ROOMHF: The development of cutaneous hypersensitiveness following the intestinal absorption of antigenic protein, Proc. Soc. Exper. Biol. and Med. 23: 176, 1925. CrossrefGoogle Scholar20. FitzgeraldSherman JDWB: The specificity of blocking antibody induced by grass pollen extracts, J. Allergy 20: 286, 1949. CrossrefMedlineGoogle Scholar21. Code CF: Histamine in blood, Physiol. Rev. 32: 47, 1952. CrossrefMedlineGoogle Scholar22. CookeBarnardHebaldStull RAJHSA: Serological evidence of immunity with coexisting sensitization in a type of human allergy, J. Exper. Med. 62: 733, 1935. CrossrefMedlineGoogle Scholar23. CookeLovelessStull RAMHA: Studies on immunity in a type of human allergy (hay fever): serologic response of non-sensitive individuals to pollen injections, J. Exper. Med. 66: 689, 1937. CrossrefMedlineGoogle Scholar24. Kern R: Asthma and allergic rhinitis due to sensitization to phthalic anhydride, J. Allergy 10: 164, 1939. CrossrefGoogle Scholar25. Leftwich WB: An intradermal test for the recognition of hypersensitivity to the sulfonamide drugs, Bull. Johns Hopkins Hosp. 74: 26, 1944. Google Scholar26. Gelfand ML: Hypersensitivity to Mercuhydrin with positive skin test to post-treated Mercuhydrin serum, J. Allergy 20: 404, 1949. CrossrefGoogle Scholar27. WeismanGelfand LHH: Mercaptomerin sensitivity, report of a case, J. A. M. A. 147: 1559, 1951. CrossrefMedlineGoogle Scholar28. ShermanCooke WBRA: Sulfadiazine sensitivity with demonstrable skinsensitizing antibody in the serum, Am. J. Med. 2: 588, 1947. CrossrefMedlineGoogle Scholar29. Whittemorede Gara ALPF: Sulfadiazine sensitivity: an unusual case with successful passive transfer, J. Allergy 18: 382, 1947. CrossrefMedlineGoogle Scholar30. Gottlieb PM: Sensitivity to mercurial diuretics: report of a case of urticaria due to Mercupurin, Ann. Allergy 6: 518, 1948. MedlineGoogle Scholar31. GoodmanLevy MHCS: Development of cutaneous eruption during administration of sulfanilamide, J. A. M. A. 109: 1009, 1937. CrossrefGoogle Scholar32. Cooke RA: Protein derivatives as factors in allergy, Ann. Int. Med. 16: 71, 1942. LinkGoogle Scholar33. CrepeaCooke SBRA: Study on the mechanism of dermatitis venenata in the guinea pig with a demonstration of skin sensitizing antibody by passive transfer, J. Allergy 19: 353, 1948. CrossrefMedlineGoogle Scholar34. Chase MW: The cellular transfer of cutaneous hypersensitivity to tuberculin, Proc. Soc. Exper. Biol. and Med. 59: 134, 1945. CrossrefGoogle Scholar35. Cooke RA: Infective asthma: indications of its allergic nature, Am. J. M. Sc. 133: 309, 1932. CrossrefGoogle Scholar36. Lawrence HS: The cellular transfer of cutaneous hypersensitivity to tuberculin in man, Proc. Soc. Exper. Biol. and Med. 71: 516, 1949. CrossrefMedlineGoogle Scholar37. Rich AR: The role of hypersensitivity in periarteritis nodosa as indicated by 7 cases developing during serum sickness and sulfonamide therapy, Bull. Johns Hopkins Hosp. 71: 123, 1942. Ibid.: Additional evidence of the role of hypersensitivity in the etiology of periarteritis, Bull. Johns Hopkins Hosp. 71: 375, 1942. Google Scholar38. GelfandAranoff MLS: Periarteritis nodosa—possible relation to the increased usage of the sulfonamides, Ann. Int. Med. 30: 919, 1949. LinkGoogle Scholar39. WilsonAlexander KSHL: The relation of periarteritis nodosa to bronchial asthma and other forms of hypersensitiveness, J. Lab. and Clin. Med. 30: 195, 1945. Google Scholar40. Rich AR: Hypersensitivity in disease with especial reference to periarteritis nodosa, rheumatic fever, disseminated lupus erythematosus and rheumatoid arthritis, Harvey Lectures, 1946-47, p. 106. Google Scholar41. Kampmeier RH: Vascular diseases due to hypersensitivity—so-called diffuse collagen disease, Am. Prac. and Digest. Treat. 1: 113, 1950. MedlineGoogle Scholar42. LangeWeinerGoldTchertkoffSimon KDMMVV: Autoantibodies in different phases of human glomerulonephritis, Bull. New York Acad. Med. 25: 447, 1949. MedlineGoogle Scholar43. SpainFontanaDe Sanctis WCVJA: To be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Read at the Symposium upon Allergic Conditions, University of Minnesota, Minneapolis, May 15, 1952. Received for publication August 11, 1952.From the Department of Medicine, New York University Post-Graduate Medical School, and the Division of Allergy of the Medical Service, University Hospital, New York.†Since the original observations of Metchnikoff and those of subsequent workers were made of necessity upon the fate of particulate matter, the phenomenon of phagocytosis is generally considered as occurring only with materials of easily discernible physical structure. Particulateness, arbitrarily defined, is a condition of matter with the characteristic of visible dimensions, microscopic or otherwise. Phagocytosis may conceivably be incited by substances of molecular size, too minute to be visible or to be accepted as "particulate." Most studies of the phenomenon have been made upon material parenterally injected, although it may well enter the organism through other portals, such as the bronchial and gastro-intestinal mucosa and the skin. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byImmunologic aspects of penicillin reactionsTRICHINOSIS: REPORT OF CASE MANIFESTING MYOCARDITIS, ENCEPHALITIS AND RADIAL NEURITIS; RESPONSE TO ACTH; REVIEW OF LITERATURE REGARDING THE ERYTHROCYTE SEDIMENTATION RATE*DAN C. ROEHM, M.D. 1 February 1953Volume 38, Issue 2Page: 188-198KeywordsAllergy and immunologyFoodGastroenterology and hepatologyHospital medicineMedical servicesMucous membranesNutritionParticulatesPhagocytosis ePublished: 1 December 2008 Issue Published: 1 February 1953 PDF downloadLoading ...