Genetic Diseases, Chromosome Rearrangements, and Malignancy
Authors: JEAN DE GROUCHY
Journal: Annals of Internal Medicine (1966)

Editorials1 September 1966Genetic Diseases, Chromosome Rearrangements, and MalignancyJEAN DE GROUCHY, M.D.JEAN DE GROUCHY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-3-603 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe first observations by German (1) and German, Archibald, and Bloom (2) on Bloom's syndrome and by Schroeder, Anschütz, and Knopp (3) on Fanconi's anemia suggested that two diseases, probably under simple genetic control, may induce an abnormal frequency of chromosome rearrangements in the somatic cells of affected individuals. Taken together with the strikingly increased prevalence of malignancy in the same patients, these observations prove highly significant in the general problem of the relation between chromosomal aberrations and malignancy.This issue of the ANNALSpresents two outstanding contributions to this subject. One paper, by Swift and Hirschhorn, reports on two...References1. GERMAN J: Cytological evidence for crossing-over in vitro in human lymphoid cells. Science 144: 298, 1964. CrossrefMedlineGoogle Scholar2. GERMANARCHIBALDBLOOM JRD: Chromosomal breakage in a rare and probably genetically determined syndrome of man. Science 148: 506, 1965. CrossrefMedlineGoogle Scholar3. SCHROEDERANSCHÜTZKNOPP TMFA: Spontane Chromosomenaberrationen bei familiärer Panmyelopathie. Humangenetik 1: 194, 1964. MedlineGoogle Scholar4. BLOOMWARNERGERALDDIAMOND GESPSK: Chromosome abnormalities in constitutional aplastic anemia. New Eng. J. Med. 274: 8, 1966. CrossrefMedlineGoogle Scholar5. BLOOM D: Congenital telangiectatic erythema resembling lupus erythematosus in dwarfs. Amer. J. Dis. Child. 88: 754, 1954. Google Scholar6. GROUCHYJOBROSSIER JDJCA: Cytogenetic studies on a case of Bloom's syndrome. Unpublished data. Google Scholar7. BLOOM D: The syndrome of congenital telangiectatic erythema and stunted growth. Observations and studies. J. Pediat. 68: 103, 1966. CrossrefMedlineGoogle Scholar8. SCHMIDSCHÄRERBAUMANNFANCONI WKTG: Chromosomenbrüchigkeit bei der familiären Panmyelopathie (Typus Fanconi). Schweiz. Med. Wschr. 95: 1461, 1965. MedlineGoogle Scholar9. KEMPSTAFFORDTANNER NHJLR: Chromosome studies during early and terminal chronic myeloid leukaemia. Brit. Med. J. 1: 1010, 1964. CrossrefMedlineGoogle Scholar10. LEJEUNE J: Leucémies et cancers, in Les Chromosomes Humains. TURPIN, R., LEJEUNE, J., Gauthier Villars Ed., Paris, 1965, pp. 181-215. Google Scholar11. ENGELFLEXNERENGEL DE MONTMOLLINFRANK ECMMLHE: Blood and skin chromosomal alterations of a clonal type in a leukemic man previously irradiated for a lung carcinoma. Cytogenetics (Basel) 3: 228, 1964. CrossrefMedlineGoogle Scholar12. GROUCHYNAVACANTUBILSKI-PASQUIERBOUSSER JDCDJMGJ: Models for clonal evolutions. A study of chronic myelogenous leukemia. Amer. J. Hum. Genet. In press, 1966. Google Scholar13. GROUCHYVALLEENAVALAMY JDGCDM: Analyse chromosomique de cellules cancéreuses et de cellules médullaires et sanguines irradiées in vitro. Ann. Genet. (Paris) 6: 9, 1963. MedlineGoogle Scholar14. ALLISONPATON ACGR: Chromosome damage in human diploid cells following activation of lysosomal enzymes. Nature (London) 207: 1170, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: CNRS Clinique de Génétique Médicale Hôpital des Enfants-Malades Paris France PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBloom's syndrome. V. Surveillance for cancer in affected familiesCytogenetic analysis of X-ray-induced chromosome aberrations in spontaneously leukaemic AKR miceDisorders of Bone Marrow ProductionNeigung zu Chromosomenbr�chen bei Russel-SyndromRecent advances in molecular pathology: A reviewGenetic Factors in CarcinomaAlterations in chromosomes and DNA content in gynecologic neoplasmsChromosomal peculiarities and ?in vitro? examinations in Fanconi's anaemiaCytogenetische, immunologische und cytologische Familienuntersuchungen bei Bloom-SyndromPerspectives in The Epidemiology Of LeukemiaINTRODUCTIONINTRODUCTIONA Chromosomal Theory of CarcinogenesisJEAN DE GROUCHY, M.D., CRISTINA DE NAVA, M.D.Human chromosomal breakageLysosomes in relation to cancer induction and treatmentThe possible role of genetic factors in carcinogenesisSingle Stranded DNA in Lymphocyte ChromosomesHistory of Cancer Genetics in ManHEPATIC CIRRHOSIS AND DIABETES MELLITUSCHROMOSOME BREAKAGE AND LEUKÆMIA 1 September 1966Volume 65, Issue 3Page: 603-607KeywordsAnemiaCellsChromosomal diseasesChromosomesGenetic diseases Issue Published: 1 September 1966 PDF DownloadLoading ...