BARBITURATE INTOXICATION: A CLINICAL ELECTROENCEPHALOGRAPHIC STUDY
Authors: Robert Cohn, Charles Savage, George N. Raines
Journal: Annals of Internal Medicine (1950)

Article1 June 1950BARBITURATE INTOXICATION: A CLINICAL ELECTROENCEPHALOGRAPHIC STUDYROBERT COHN, M.D., CHARLES SAVAGE, GEORGE N. RAINESROBERT COHN, M.D.Search for more papers by this author, CHARLES SAVAGESearch for more papers by this author, GEORGE N. RAINESSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-6-1049 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the process of recording from a large number of patients admitted to this hospital in comatose states, it has been observed that individuals rendered unconscious by barbiturate drugs present a remarkably homogeneous EEG pattern. This pattern can be clearly differentiated from the recordings obtained in comatose states induced by all other agents and pathophysiologic mechanisms that have come under our observation.The characteristic EEG pattern of barbiturate intoxication consists of a random frequency high voltage type. Slow waves occur in isolated and short sequences of sinusoidal 160 to 250 millisecond waves and in nonsinusoidal (or complex sinusoidal) slower discharges...Bibliography1. Hambouger WE: Promiscuous use of barbiturates, J. A. M. A. 112: 1340-1343, 1939; 114: 2015-2019, 1940. CrossrefGoogle Scholar2. GoodmanGilman LA: The pharmacological basis of therapeutics, 1940, New York. Google Scholar3. Hyman HT: An integrated practice of medicine, Vol. IV, 1947, W. B. Saunders, Philadelphia. Google Scholar4. KoppanyiMurphyKrop TWSS: Colorimetric detection of barbital and its applications, Proc. Soc. Exper. Biol. and Med. 30: 542-544, 1933. CrossrefGoogle Scholar5. KoppanyiMurphyKrop TWSS: Methods and results of barbital research Proc. Soc. Exper. Biol. and Med. 30: 1405-1407, 1933. CrossrefGoogle Scholar6. GreenVeitchKoppanyi MWFPT: Studies on barbiturate. XXVI. The use of Lloyd's reagent in the quantitative estimation of barbiturate in the urine, J. Am. Pharm. Ass. 32: 309-311, 1943. CrossrefGoogle Scholar7. Ozburn EF: Identification of barbiturates, Hosp. Corps Quart. 18: 49-52, 1945. Google Scholar8. KozelkaTatum FLHJ: Quantitative study of barbiturates in cerebrospinal fluid, J. Pharmacol. and Exper. Therap. 59: 63-67, 1937. Google Scholar9. Rovenstine EA: The incidence, diagnosis, and management of coma, Anesthesiology 6: 1-11, 1945. CrossrefGoogle Scholar10. SolomonAring PCD: The differential diagnosis in patients entering the hospital in coma, J. A. M. A. 105: 7-10, 1935. CrossrefGoogle Scholar11. CohnKatzenelbogen RS: Electroencephalographic changes induced by intravenous sodium amytal, Proc. Soc. Exper. Biol. and Med. 49: 560-563, 1942. CrossrefGoogle Scholar12. BrazierFinesinger MAJE: Action of barbiturates on cerebral cortex; EEG study, Arch. Neurol. and Psychiat. 53: 51-58, 1945. CrossrefGoogle Scholar13. JonescoSisestiSagerKreindler NOOA: Electroencephalogramme pendant le coma et apres la mort, Academia Romana Bukharest. Bulletin de la section scientifique, Tome XXII, eme, No. 9: 391, 1939-1940. Google Scholar14. FischgoldBounes HG: Exploration electroencephalographiques des etats comateux, Sem. Hop. Par. 22: 1245, 1946. MedlineGoogle Scholar15. DempseyMorrison EWRS: The problem of rhythmically recurrent cortical potentials after localized thalamic stimulation, Am. J. Physiol. 135: 293-300, 1942. CrossrefGoogle Scholar16. Cohn R: Analysis of the spike-dome complex by high-speed photography, 2nd Annual Meeting of the American Electroencephalographic Society, June, 1948. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, Maryland*Received for publication September 4, 1948.From the U. S. Naval Hospital, National Naval Medical Center, Bethesda, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE VALUE AND LIMITATIONS OF ELECTROENCEPHALOGRAPHYEEG in Fatal and Near-Fatal Poisoning with Soporific Drugs: II. Clinical SignificanceElectroencephalograms during comaElectroencephalograms during ComaSedatives and HypnoticsTHE VALUE AND LIMITATIONS OF ELECTROENCEPHALOGRAPHYEye Disturbances in Bromide Intoxication*Newer Methods of Evaluation of Patients with Altered States of ConsciousnessBARBITURATE ADDICTION SIMULATING SPONTANEOUS HYPERINSULINISMDas Hirnstrombild im Verlauf der Schlafmittelvergiftung und seine differentialdiagnostische BedeutungThe EEG in sedative withdrawal 1 June 1950Volume 32, Issue 6Page: 1049-1065KeywordsComaDrugsElectroencephalographyIntoxication ePublished: 1 December 2008 Issue Published: 1 June 1950 PDF downloadLoading ...