COLD AUTOHEMOLYSIS ASSOCIATED WITH RAYNAUD'S SYNDROME: REPORT OF CASE
Authors: J P DAVIS, D ROSENBAUM
Journal: Annals of Internal Medicine (1949)

Case Reports1 March 1949COLD AUTOHEMOLYSIS ASSOCIATED WITH RAYNAUD'S SYNDROME: REPORT OF CASEJOHN P. DAVIS, M.D., F.A.C.P., DAVID ROSENBAUM, M.D.JOHN P. DAVIS, M.D., F.A.C.P.Search for more papers by this author, DAVID ROSENBAUM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-3-681 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCold autohemolysis denotes the presence in the blood of an immunologic reactor (autohemolysin), which at low temperatures unites with red cells to produce a hemolytic reaction. Hemoglobinemia and, if hemolysis is sufficiently marked, hemoglobinuria will result.Paroxysmal hemoglobinuria has been frequently recognized since its first description by Dressler1in 1854. It is known to occur following several conditions: exposure to cold, physical exercise (March hemoglobinuria), ingestion of the fava bean, and in chronic hemolytic anemia (syndrome of Marchia Fava-Michaeli). Gull1in 1866 first noted the relation of the exposure to cold to this syndrome, and in 1880 Rosenbach1demonstrated an...Bibliography1. Cited by MACKENZIE.4 Google Scholar2. Cited by DILL, DOUVROS and ISENHAUR.3 Google Scholar3. DILLDOUVROSISENHAUR LVIEE: Observations on the incidence of latent paroxysmal hemoglobinuria as evidenced by the Donath-Landsteiner phenomenon, Am. Jr. Syph., Gon., and Ven. Dis., 1939, xxiii, 220. Google Scholar4. MACKENZIE GM: Paroxysmal hemoglobinuria, a review, Medicine, 1929, viii, 69. Google Scholar5. HINES EA: Significance of vascular hyper-reaction as measured by cold-pressor test, Am. Heart. Jr., 1940, xix, 408-416. CrossrefGoogle Scholar6. WINTROBE MM: Clinical Hematology, 7th Ed., 1942, Lea and Febiger, Philadelphia, p. 382. Google Scholar7. STATSWASSERMANN DLR: Cold hemagglutination—an interpretative review, Medicine, 1943, xxii, 363. CrossrefGoogle Scholar8. COHN WE: The determination of hemoglobin in tissue extracts or other turbid solutions, Jr. Biol. Chem., 1943, cxlviii, 219. CrossrefGoogle Scholar9. ROTH G: Paroxysmal hemoglobinuria with vasomotor and agglutinative features, Proc. Staff Meet. Mayo Clin., 1925, x, 609. Google Scholar10. BENIANS TH: Vasospastic factor in serum of case of Raynaud's disease with cold agglutination, experiments on rabbits, Jr. Lab. and Clin. Med., 1944, xxix, 1074-1081. Google Scholar11. STATSBULLOWA DJG: Cold hemagglutination with symmetric gangrene of tips of extremities, report of case, Arch. Int. Med., 1943, lxxii, 506-517. CrossrefGoogle Scholar12. JONES CM: Study of the bile pigments by means of duodenal tube in case of paroxysmal hemoglobinuria, Med. Clin. N. Am., 1922, v, 1421. Google Scholar13. BESTTAYLOR CHNB: Physiological Basis of Medical Practice, 3rd Ed., 1943, Williams and Wilkins Co., Baltimore, p. 83. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 9, 1946.From the Station Hospital, Camp Gordon, Georgia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySerologie und Klinik der autoimmunhämolytischen Erkrankungen 1 March 1949Volume 30, Issue 3Page: 681-691KeywordsBlood cellsCellsCyclic adenosine monophosphateExerciseHemoglobinHemolytic anemiaIngestionRaynaud syndromeResearch laboratoriesTemperature ePublished: 1 December 2008 Issue Published: 1 March 1949 PDF downloadLoading ...