tbuckley/cabot-search huggingface dataset:
Light-responsive nanoparticle depot to control release of a small molecule angiogenesis inhibitor in the posterior segment of the eye
Authors: Viet Anh Nguyen Huu, Jing Luo, Jie Zhu, Jing Zhu, Sherrina Patel, Alexander Boone, Enas Mahmoud, Cathryn McFearin, Jason Olejniczak, Caroline de Gracia Lux, Jacques Lux, Nadezda Fomina, Michelle Huynh, Kang Zhang, Adah Almutairi
Journal: Journal of Controlled Release (2015)
Clinical, biochemical, serological, histological and ultrastructural features of liver disease in drug abusers.
Authors: I V Weller, D Cohn, A Sierralta, M Mitcheson, M G Ross, L Montano, P Scheuer, H C Thomas
Journal: Gut (1984)

Heroin abusers are frequently found to have abnormal liver function tests and hepatic histology. Hepatitis viruses A, B, and NANB, other drugs or drug contaminants and excessive alcohol consumption are factors thought to contribute. One hundred and sixteen heroin abusers attending a London treatment centre were studied. Sixty two (53%) had a raised aspartate transaminase. This was not explained by current infection with hepatitis A and B, cytomegalo or Epstein-Barr viruses, excessive alcohol consumption (greater than 80 g/day) or concomitant drug taking. Abnormal liver function tests were as frequent in those with markers of current or past HBV infection as those without and there was evidence that both HBV infection and the cause of the abnormal liver function tests were acquired in the first few years of intravenous drug abuse. Liver biopsies from eight patients showed chronic hepatitis with a mild lobular and portal inflammatory infiltrate, fatty change and prominent sinusoidal cells. Electron microscopy showed cytoplasmic trilaminar tubular structures and dense fused membranes in dilated endoplasmic reticulum. These clinical, biochemical, serological, and histological features would suggest a major role for NANB virus infection in the aetiology of hepatitis in heroin abusers.
Recurrent post-herpetic erythema multiforme mimicking polymorphic light and juvenile spring eruption: report of two cases in young boys
Authors: P. WOLF, H.P. SOYER, R. FINK-PUCHES, J.C. HUFF, H. KERL
Journal: British Journal of Dermatology (1994)

Journal Article Recurrent post‐herpetic erythema multiforme mimicking polymorphic light and juvenile spring eruption: report of two cases in young boys Get access P. WOLF, P. WOLF Department of Dermatology, University of Graz, Graz. Austria Dr P. Wolf. Department of Dermatology. University of Graz. Auenbruggerplatz 8. A‐8036 Graz. Austria. Search for other works by this author on: Oxford Academic Google Scholar H.P. SOYER, H.P. SOYER Department of Dermatology, University of Graz, Graz. Austria Search for other works by this author on: Oxford Academic Google Scholar R. FINK‐PUCHES, R. FINK‐PUCHES Department of Dermatology, University of Graz, Graz. Austria Search for other works by this author on: Oxford Academic Google Scholar J.C. HUFF, J.C. HUFF Department of Dermatology. University of Colorado Medical, School, Denver, CO. U.S.A. Search for other works by this author on: Oxford Academic Google Scholar H. KERL H. KERL Department of Dermatology, University of Graz, Graz. Austria Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 131, Issue 3, 1 September 1994, Pages 364–367, https://doi.org/10.1111/j.1365-2133.1994.tb08525.x Published: 01 September 1994 Article history Accepted: 11 March 1994 Published: 01 September 1994
Kill the QOF
Authors: D. Spence
Journal: BMJ (2013)

We are entering the 10th year of the world’s largest public health experiment in evidenced based medicine—the target driven QOF (Quality and Outcomes Framework). It has cost £10bn in direct payments to general practitioners,1 but this is just the tip of an expensive iceberg. Hidden are the appointments systems overloaded with arbitrary “reviews” and huge increases in investigations and prescribing. Once highly functional general practice computing systems are now clogged with constant pop-up reminders to enter data that are meaningless, useless, and frankly often erroneous. …
Quantitative Expression of the Mutated Lamin A/C Gene in Patients With Cardiolaminopathy
Authors: Nupoor Narula, Valentina Favalli, Paolo Tarantino, Maurizia Grasso, Andrea Pilotto, Riccardo Bellazzi, Alessandra Serio, Fabiana I. Gambarin, Philippe Charron, Benjamin Meder, Yigal Pinto, Perry M. Elliott, Jens Mogensen, Martino Bolognesi, Michela Bollati, Eloisa Arbustini
Journal: Journal of the American College of Cardiology (2012)
Human epidermal T cells predominantly belong to the lineage expressing alpha/beta T cell receptor.
Authors: C A Foster, H Yokozeki, K Rappersberger, F Koning, B Volc-Platzer, A Rieger, J E Coligan, K Wolff, G Stingl
Journal: The Journal of Experimental Medicine (1990)

The epidermis of clinically normal-appearing human skin harbors a phenotypically heterogeneous population of T lymphocytes (TCs), the majority of which are CD2+/CD3+/CD5+ "memory" cells, but in an unactivated state, and express the TCR-alpha/beta. In contrast to murine skin, only a very minor subpopulation of CD3+ cells in the human epidermis bears the TCR-gamma/delta. Epidermal TCs primarily are distributed along the rete ridges in the basal keratinocyte layer and are often in close apposition to Langerhans cells (LCs). These TCs were propagated from epidermal cell suspensions after stimulation with TC activating agents (Con A, rIL-1, rIL-2), then evaluated for phenotypic features and TCR diversity. Similar to the in situ situation, most were CD4-/CD8+/TCR-alpha/beta+. In addition, two cultures contained TCR-gamma/delta+ cells; one of these determined to be an adherent CD4-/CD8+ population. Epidermal TCs were significantly (p less than 0.0001) more abundant in the sole than in the other body regions examined (i.e., 40 vs. 7 CD3+ cells/linear centimeter of epidermis) and seemed to have a particular affinity for the acrosyringial epithelium of eccrine sweat ducts. Moreover, the sole usually contained a greater number of CD8+ relative to CD4+ TCs, whereas the epidermal CD4/CD8 ratio in the trunk and extremities was quite variable, although the trend also was towards a slightly larger percentage of CD8+ cells. Collectively, our data suggest that the volar epidermis has a unique microenvironment which is responsible for both the higher density of TCs, preferentially CD8+, and lower number of LCs. This study has not only provided evidence for significant regional variability in the human epidermal TC population of normal skin, but also strengthens the concept for skin-associated lymphoid tissues (SALT), whereby memory TCs recirculate back to the epidermis and interact with resident antigen-presenting cells (i.e., LC).
Dermatomyositis and myelodysplastic syndrome with myelofibrosis responding to methotrexate therapy
Authors: Goh Tsuji, Soichiro Maekawa, Katsuyasu Saigo, Yumiko Nobuhara, Tomoko Nakamura, Seiji Kawano, Masahiro Koshiba, Shunichiro Asahara, Tadanobu Chinzei, Shunichi Kumagai
Journal: American Journal of Hematology (2003)

Abstract Dermatomyositis (DM) has not yet been reported as a complication of myelodysplastic syndrome (MDS). A 50‐year‐old man was diagnosed as having MDS because of the presence of anemia, the appearance of immature cells in peripheral blood, and the abnormal cellular morphology. A few months later, high fever, myalgia and erythema developed. Although DM symptoms were resistant to high‐dose corticosteroid administration, methotrexate (MTX) therapy improved not only the symptoms of DM but also hematologic findings related to MDS. This indicates that immunosuppressive therapy including MTX administration can be useful for patients with MDS with autoimmune symptoms. Am. J. Hematol. 74:175–178, 2003. © 2003 Wiley‐Liss, Inc.
Emergency Treatment Service
Authors: A. R. Anderson
Journal: BMJ (1967)

may find it impossible to attend the necropsy, and so valuable teaching material is lost.Furthermore, coroners should normally be expected to meet or to discuss with medical staff before deciding whether to hold an inquest.The Scottish system of a procurator fiscal, or some modification of this procedure, has much to recommend it.Whatever changes are advised, a much closer liaison between the coroners and hospital medical staff would better serve the interests of truth, justice, and science.-Iam, etc.,
INDUCED PROTECTION OF ADRENAL CORTEX AGAINST 7,12-DIMETHYLBENZ[<i>a</i>]ANTHRACENE
Authors: Charles Huggins, Ryo Fukunishi
Journal: The Journal of Experimental Medicine (1964)

7,12-Dimethylbenz[a]anthracene (7,12-DMBA) exerts adrenocorticolytic effects which set it apart from all other polynuclear aromatic hydrocarbons and aromatic amines which have been investigated. Adrenal damage by this compound appears to be due to its steric and electronic properties together with its unusually high solubility in lipides. Many compounds given prior to 7,12-DMBA induced protection of adrenal. The most efficient inducers of protection are flat condensed aromatics possessing 4 or 5 rings; very small doses of these compounds were required to induce protection. Other compounds devoid of these properties induced protection but large or repeated doses were necessary. All inducers of protection had to be given prior to 7,12-DMBA to prevent adrenal necrosis; when given simultaneously with, or later than, this compound adrenal apoplexy resulted. Protective aromatics and 7,12-DMBA as well induced synthesis of menadione reductase in liver. 3-Methylcholanthrene (3-MC) induced this enzyme in many normal organs including liver, lung, adrenal, and in mammary cancer as well. dl-Ethionine under appropriate conditions of time and dosage eliminated the adrenal protection induced by aromatics and also delayed the induction of menadione reductase while depressing the amount of this enzyme which was synthesized. 7,12-DMBA caused a greatly reduced incorporation of tritium from thymidine-H3 into washed acid-insoluble residue of adrenal. 3-MC given in advance mitigated the drastic effect of 7,12-DMBA on DNA synthesis and increased considerably the amount of tritium which was incorporated. The specific damage to adrenal by 7,12-DMBA is a direct effect on cells. Protection of adrenal is a secondary effect which requires induction of protein synthesis and it results in improvement in synthesis of DNA.
Symmetric Bony Involvement of the Lower Extremities With Lymphoma Demonstrated on Gallium Scintigraphy
Authors: Choong L. Wong, Robert Mansberg, Malia Yosufzai
Journal: Clinical Nuclear Medicine (2005)

Primary or secondary lymphoma of the bone is uncommon. The sites of bony involvement include, in decreasing order of frequency, the spine, long bones, pelvis, ribs, and skull. A 66-year-old man with an atypical lineage of B-cell non-Hodgkin lymphoma is presented. The unusual initial presentation of the lymphoma included symmetric bony involvement of bilateral tibiae and the distal right femur, demonstrated on gallium-67 scintigraphy. The patient subsequently demonstrated resolution of the gallium-avid disease after treatment with fludarabine, cyclosporine, and ATG. This case also demonstrates the limitations of plain radiograph and the usefulness of MRI in the diagnosis of bony lymphoma.
Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma
Authors: Ryosuke Muroyama, Naoya Kato, Haruhiko Yoshida, Motoyuki Otsuka, Masaru Moriyama, Yue Wang, Run-Xuan Shao, Narayan Dharel, Yasuo Tanaka, Miki Ohta, Ryosuke Tateishi, Shuichiro Shiina, Masashi Tatsukawa, Kenichi Fukai, Fumio Imazeki, Osamu Yokosuka, Yasushi Shiratori, Masao Omata
Journal: Journal of Hepatology (2006)
18F-FDG PET/CT Appearance of Metastatic Brachial Plexopathy Involving Epidural Space From Breast Carcinoma
Authors: Linh Ho, Robert Henderson, Thang Luong, Silva Malkhassian, Heidi Wassef
Journal: Clinical Nuclear Medicine (2012)

Patient is a 74-year-old woman with a history of breast carcinoma and known metastatic brachial plexopathy and pulmonary and mediastinal nodal involvement. She had bilateral mastectomies 5 years ago and is currently on chemotherapy. A 6-month follow-up PET/CT study demonstrated no significant interval change in intensity of the previously evident hypermetabolic activity of the brachial plexopathy. However, this activity has extended superiorly and medially involving the right lateral aspect of the epidural space at the C5-6 level, consistent with epidural involvement. In addition, the hypermetabolic activity of the pulmonary and mediastinal metastases has also increased, consistent with interval progression of the disease.
Attitudes and Practices of U.S. Oncologists regarding Euthanasia and Physician-Assisted Suicide
Authors: Ezekiel J. Emanuel
Journal: Annals of Internal Medicine (2000)

The practices of euthanasia and physician-assisted suicide remain controversial.To achieve better understanding of attitudes and practices regarding euthanasia and physician-assisted suicide in the context of end-of-life care.Cohort study.United States.3299 oncologists who are members of the American Society of Clinical Oncology.Responses to survey questions on attitudes toward euthanasia and physician-assisted suicide for a terminally ill patient with prostate cancer who has unremitting pain, requests for and performance of euthanasia and physician-assisted suicide, and sociodemographic characteristics.Of U.S. oncologists surveyed, 22.5% supported the use of physician-assisted suicide for a terminally ill patient with unremitting pain and 6.5% supported euthanasia. Oncologists who were reluctant to increase the dose of intravenous morphine for terminally ill patients in excruciating pain (odds ratio [OR], 0.61 [95% CI, 0.48 to 0.77]) and had sufficient time to talk to dying patients about end-of-life care issues (OR, 0.79 [CI, 0.71 to 0.87]) were less likely to support euthanasia or physician-assisted suicide. During their career, 3.7% of surveyed oncologists had performed euthanasia and 10.8% had performed physician-assisted suicide. Oncologists who were reluctant to increase the morphine dose for patients in excruciating pain (OR, 0.58 [CI, 0.43 to 0.79]) and those who believed that they had received adequate training in end-of-life care (OR, 0.86 [CI, 0.79 to 0.95]) were less likely to have performed euthanasia or physician-assisted suicide. Oncologists who reported not being able to obtain all the care that a dying patient needed were more likely to have performed euthanasia (P = 0.001).Requests for euthanasia and physician-assisted suicide are likely to decrease as training in end-of-life care improves and the ability of physicians to provide this care to their patients is enhanced.
A pilot study of ribavirin therapy for chronic hepatitis C
Authors: Adrian M. di Bisceglie, Michiko Shindo, Tse-Ling Fong, Michael W. Fried, Mark G. Swain, Nora V. Bergasa, Constantine A. Axiotis, Jeanne G. Waggoner, Yoon Park, Jay H. Hoofnagle
Journal: Hepatology (1992)

Interferon-alpha therapy is of proven efficacy in chronic hepatitis C, but it is not universally effective and may be associated with intolerable side effects. Ribavirin is a nucleoside analog with a broad spectrum of antiviral action. We conducted an uncontrolled pilot study of ribavirin therapy in 13 patients with chronic hepatitis C. Ribavirin was given for 6 mo, in a dose that was increased, at 2-mo intervals, from 600 mg to 1,000 mg to 1,200 mg/day. Serum ALT levels gradually decreased in all 13 treated patients; the mean percentage of decrease was 67% (from 210 U/L [range = 109 to 593] to 63 U/L [range = 22 to 108 U/L]; p = 0.0006) after 6 mo of treatment. Serum aminotransferase levels fell to the normal range in four patients (31%). In the 3 to 6 mo after cessation of ribavirin therapy, serum aminotransferase activities gradually rose to near pretreatment levels in all but one patient. Therapy was associated with a significant decrease in the geometric mean titer of hepatitis C virus RNA in serum (1:1,981 vs. 1:199; p less than 0.02) although no patients lost hepatitis C virus RNA from serum during therapy. No significant improvement was seen in liver histological appearance. Ribavirin therapy resulted in mild, reversible hemolysis; no patient exhibited symptomatic anemia. These findings suggest that ribavirin has a beneficial effect in patients with chronic hepatitis C, although further studies are needed to determine how ribavirin is best used.
Dipyridamole enhancement of drug sensitivity in acute lymphoblastic leukemia cells
Authors: Manabu Sotomatsu, Shin‐Ichirou Yugami, Toshiji Shitara, Takayoshi Kuroume
Journal: American Journal of Hematology (1993)

The effect of dipyridamole (DPM) on cell sensitivity to anticancer drugs was examined in acute lymphoblastic leukemia (ALL) cell lines. We established two ALL cell lines (KMO-90 and KMO-R) from bone marrow samples of a 12-year-old girl with ALL. The drug concentrations needed to reduce optical density to 50% of that of control cells (IC50) showed that KMO-R was about twofold more resistant to doxorubicin (DOX), mitoxantrone (MIT), vincristine (VCR), and etoposide (VP-16) than was KMO-90. Considering that both KMO-90 and KMO-R were established from a patient with ALL at the time of presentation and relapse, respectively, these two cell lines might be novel and useful models for research into the acquisition of drug resistance in ALL cells. Although cytotoxicity of DPM in KMO-90 was about 6% at 1 microgram/ml, DPM enhanced cell sensitivity to DOX, MIT, VCR, and VP-16 at this concentration. Cytotoxicity of DPM in KMO-R was less than 5% at 1, 5, and 10 micrograms/ml. In KMO-R, DPM enhanced cell sensitivity to these four drugs in a dose-dependent manner. The plasma concentrations achieved by oral administration of DPM is about 1 microgram/ml. At clinically achievable concentrations, DPM enhanced cell sensitivity to DOX, MIT, VCR, and VP-16 in both KMO-90 and KMO-R, thus showing DPM to be a useful agent for potentiating anticancer chemotherapy of hematopoietic malignancy.
Beta-blocker treatment of dilated cardiomyopathy. Beneficial effect of carteolol in mice.
Authors: M Tominaga, A Matsumori, I Okada, T Yamada, C Kawai
Journal: Circulation (1991)

The effects of carteolol, a nonselective beta-adrenergic receptor blocker with intrinsic sympathomimetic activity, were compared with those of metoprolol in a murine model of viral myocarditis and dilated cardiomyopathy caused by encephalomyocarditis virus.In the acute experiment, BALB/c and DBA/2 mice were inoculated with encephalomyocarditis virus. BALB/c mice were then given carteolol at 1 (n = 10), 10 (n = 10), 30 (n = 11), or 100 mg/kg (n = 9) daily, and DBA/2 mice were given carteolol at 1 (n = 9) or 10 mg/kg (n = 9) daily starting the day of inoculation. Controls were given distilled water (n = 23 for BALB/c mice and n = 8 for DBA/2 mice). BALB/c mice were killed on day 7, and DBA/2 mice were killed on day 14. In the subacute experiment, DBA/2 mice were inoculated with the virus and then given carteolol at 1 (n = 12) or 10 mg/kg (n = 16), or distilled water (n = 27) daily, starting on day 14. Mice were killed on day 28. Virus replication, murine survival, heart weight to body weight ratio, and histopathological findings were similar in each group in the acute and subacute experiments. In the chronic experiment, DBA/2 mice were inoculated with the virus and were then given carteolol at 1 (n = 13) or 10 mg/kg (n = 9), metoprolol at 30 mg/kg (n = 9), or distilled water (n = 31) daily, starting on day 14. Mice were killed on day 104. Heart weight to body weight ratio and histopathological scores were significantly lower in mice given carteolol than in the infected control group. Furthermore, left ventricular cavity dimension, left ventricular wall thickness, and myocardial fiber diameter of the left ventricle were significantly reduced in mice given carteolol compared with the control group. Metoprolol did not cause any significant changes compared with the control group.This study suggests that carteolol prevents the development of myocardial lesions similar to those in dilated cardiomyopathy after myocarditis in the chronic stage.
Measurement and Data Collection in Medical Practice
Authors: Keshav Chander
Journal: Annals of Internal Medicine (1998)

Letters1 November 1998Measurement and Data Collection in Medical PracticeKeshav Chander, MDKeshav Chander, MDJefferson, LA 70121Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-129-9-199811010-00036 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The timing of Nelson and colleagues' article [1] could not have been better. We have recently been observing the bigger thrust toward evidence-based medicine. Although this is a healthy trend, the need to educate the users of the evidence is greater than ever before. The problem with numbers such as sensitivity, specificity, predictive value, and number needed to treat is that they may not bail us out when it comes to the patient sitting across the desk in our clinic. The problem with probabilities is that the final result depends on pretest probability. And pretest probability needs ...References1. Nelson EC, Splaine ME, Batalden PB, Plume SK. Building measurement and data collection into medical practice. Ann Intern Med. 1998; 128:460-6. Google Scholar Author, Article, and Disclosure InformationAuthors: Keshav Chander, MDAffiliations: Jefferson, LA 70121 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1998Volume 129, Issue 9Page: 754KeywordsAbsolute risk reductionEvidence based medicineHealth careMusclesSpecificity ePublished: 15 August 2000 Issue Published: 1 November 1998 Copyright & PermissionsCopyright © 1998 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Letter: Schistosomiasis and irrigation.
Authors: H L Russell
Journal: BMJ (1974)

la-ter pane S-T segmient depres-sion was stil evident (fig.ic)despite the prespence of normial myocardial lactate extraction (+ 13 mg/100 m) at this time.It could be con- sidered -that increased coronary arterial perfusion resul-ted fromn the trinitrin therapy and produced a wash-th-rough effect, thoereby' preventing proper evalutiaon of myocardial lactate extract-ion status.Howevetr, after a further five-minute period spontaneous angina recurred, with further plane S-T segment depression (fig Id) and zero myo- cardial lactate extraction.Five minutes after a second trinitrin tablet had been givens~nposwere relieved comipletely~andthi's was associated with norm-al myocardial lactate extraction (+11-nig/ 100 ml) despite the persistence of plane S-T segment de- pression (fig.le).It was only after a furth-er 20 minute-s had elapsed, during which the patient remained asymnptomatic w-ith normal myocardial lactate extraction (+ 1-2 rig/ 100 ml), that the S-T segment regained its pree vious-ly accepted normal J-,point position (figd I) I am, etc.,
Case 41-1964
Authors: John B. Stanbury, Richard B. Cohen
Journal: New England Journal of Medicine (1964)

Presentation of CaseA sixty-year-old man entered the hospital because of chills and vomiting.Fifteen years earlier the patient had a urinary-tract infection and after cystoscopic examination was told that he had "an ulcer" in the kidney. A sulfonamide was administered, and he was later informed that the medication had "crystalized" in the kidneys. Thereafter, he was well until two weeks before admission, when he began to experience episodes of postprandial malaise and nausea. One week later urinary frequency, dysuria and nocturia developed. On the evening of admission, shortly after a meal of corned beef and buttered potatoes, there was . . .