tbuckley/cabot-search huggingface dataset:
Imaging of Takotsubo Cardiomyopathy
Authors: Dorthe Skovgaard, Lene Holmvang, Lia E. Bang, Jacob Lønborg, Philip Hasbak
Journal: Clinical Nuclear Medicine (2010)

Takotsubo cardiomyopathy is an increasingly recognized syndrome with symptoms similar to acute myocardial infarction including chest pain and ST-segment elevation, but without significant coronary stenosis. The syndrome is characterized by reversible wall-motion abnormalities involving apical and midportion of the left ventricle. A series of images, including repeated transthoracal echocardiography, cardiac single photon emission computed tomography, magnetic resonance imaging, 123I-meta-iodobenzylguanidine cardiac scintigraphy, and F-18 FDG PET are presented, investigating the clinical course of a 72-year-old woman with a typical presentation of takotsubo cardiomyopathy. The most striking features are normalization of the ventricular wall-motion, complete reversement of the extended perfusion defect, and an initial increased lung 123I-meta-iodobenzylguanidine uptake possibly explained by endothelial dysfunction due to acute heart failure.
Cardiac Care Units
Authors: Robert Oseasohn
Journal: JAMA (1976)

<h3>To the Editor.—</h3> Frieden and Cooper (235:816,1976) stated that "recent experiences with monitored cardiac care units have demonstrated that mortality can be reduced in the first few days after an acute myocardial infarction." However, critical review of articles on coronary care units fails to confirm a properly designed trial that supports that statement. Adler et al (<i>Br Med Bull</i>30:242, 1974), in a review dealing with research on medical care, point out: Mortality within most coronary care units has declined over the years, but there has also been a parallel reduction in mortality in patients suffering from myocardial infarction, who are nursed in conventional wards (MacMillan &amp; Brown, 1971). There is no evidence that hospitals play any part in altering the total picture of the disease. In fact, the first randomized controlled trial comparing home care vs that in cardiac care units (Mather et al cited by Adler et al
Expression of multiple Na+,K+-adenosine triphosphatase isoform genes in human hematopoietic cells. Behavior of the novel A3 isoform during induced maturation of HL60 cells.
Authors: M Gilmore-Hebert, J W Schneider, A L Greene, N Berliner, C A Stolle, K Lomax, R W Mercer, E J Benz
Journal: Journal of Clinical Investigation (1989)

Multiple isoenzymes of the Na+,K+-ATPase (alpha, alpha+, and alpha 3) have been identified by molecular cloning (Shull, G. E., J. Greeb, and J. B. Lingrel. 1986. Biochemistry. 25:8125-8132; and Schneider, J. W., R. W. Mercer, and E. J. Benz, Jr. 1987. Clin. Res. 35:585A. [Abstr.]). At least one of these, the alpha 3 chain, represents a novel form for which protein products and enzymatic activities are just beginning to be defined in rodents. We have recently demonstrated that expression of alpha 3 is largely confined to neuromuscular tissues of fetal and adult rats (Schneider, J. W., R. W. Mercer, M. Gilmore-Hebert, M. F. Utset, C. Lai, A. Greene, and E. J. Benz, Jr. 1988. Proc. Natl. Acad. Sci. USA. 85:284-288). We now report that certain human leukemia cell lines including HL60, HEL, and Molt 4 express mRNA for both alpha and alpha 3 isoforms of Na+,K+-ATPase; mRNA was not detected in several other cell lines, including K562 and U937; no cell lines expressed alpha+ mRNA. In uninduced HL60 cells, alpha 3 mRNA comprised 20-30% of total Na+,K+-ATPase mRNA. Furthermore, in HL60 and HEL cells, both alpha and alpha 3 mRNA declined after induction of maturation by DMSO, retinoic acid, or hemin. However, the reduction in alpha 3 mRNA was far more dramatic. alpha 3 mRNA virtually disappeared, but alpha mRNA declined by only approximately 50%. In contrast, when maturation of HL60 cells along the monocyte/macrophage lineage was induced by exposure to phorbol esters, alpha 3 mRNA remained abundant. Moreover, mRNA for the beta subunit of the Na+,K+-ATPase increased dramatically. Our results demonstrate that the alpha 3 isoform, formerly thought to be confined to neuromuscular tissues, is expressed in restricted lineages of hematopoietic origin. These leukemia cell lines should provide a useful model for analyzing regulation of the alpha 3 isoform gene and characterization of alpha 3 isoform activities.
Mammography Screening in Women Under Age 50 Years
Authors: Henry T. Lynch, Patrice Watson, Judith Schreiman, Mary Lee Fitzsimmons, Theres Conway, Jane Lynch
Journal: JAMA (1988)

To the Editor.—  The article by Eddy et al 1 provides evidence that healthy asymptomatic women between the ages of 40 and 49 years do not show sufficient health or economic benefit from mammography to offset the costs and risks. They contend that the costs for screening this cohort are high and that relatively few lives would be saved. Their data indicate that mammography screening in that decade would carry a risk of radiation-induced cancer of the breast of about 1 in 25 000. They conclude that a more prudent approach is to initiate mammography at age 50 years.  The matter of hereditary breast cancer (HBC) was totally ignored in these reports. This is surprising since HBC accounts for approximately 9% of the total breast cancer burden 2 and its average age of onset is approximately 44 years. 3,4 Indeed, we recently described a subset of HBC that is characterized
Abstract 3038: Delineating the role of Arid3B in normal and malignant differentiation of esophageal and cervical stratified squamous epithelia
Authors: Lynn Roy, Serene Samyesudhas, Karen Cowden Dahl
Journal: Cancer Research (2012)

Abstract ARID3B is DNA binding protein overexpressed in neuroblastoma and ovarian cancer. We have determined that ARID3B expression is also upregulated during squamous epithelial differentiation (cervix, skin, and esophagus). Therefore, we wanted to assess the role of ARID3B in development of squamous cell carcinomas of the esophagus and cervix. In addition to examining the expression of ARID3B, we also wanted to determine the mechanism for ARID3B regulation in cancer and normal squamous cell epithelia. Recent evidence suggests that p63, specifically the ΔNp63α isoform, transcriptionally regulates Arid3B. p63 is a member of the p53 transcription factor family and is essential for the proliferative potential of stem cells in stratified squamous epithelia. p63 is also involved in various cancers including skin cancer and esophageal cancer. In esophageal squamous cell carcinoma, p63 is ubiquitously expressed and low levels are associated with a poor prognosis. We hypothesize that p63 regulates Arid3B in normal and malignant differentiation of stratified squamous epithelium. To evaluate ARID3B expression in cancer we performed immunohistochemistry on tissue microarrays using two independent Arid3B antibodies. Loss of nuclear Arid3B appears to be common in squamous cell carcinoma of cervix and esophagus. We also examined expression of ARID3B in a normal and a squamous cell carcinoma esophageal cell line. We are also examining the coordinate expression of p63 and Arid3B in serial sections of normal and malignant tissue sections of esophagus, cervix, and skin. We are also investigating the regulation of ARID3B in 3D cell culture models of esophagus differentiation. Our data suggests that misregulation of ARID3B may contribute to the development of cancer in stratified epithelia specifically of the cervix and esophagus. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3038. doi:1538-7445.AM2012-3038
Noncirrhotic portal hypertension and nodular regenerative hyperplasia of the liver in dogs with mucopolysaccharidosis type I
Authors: Michael F. McEntee, Kathy N. Wright, Ian Wanless, Robert DeNovo, John F. Schneider, Robert Shull
Journal: Hepatology (1998)

Nodular regenerative hyperplasia (NRH) is an uncommon hepatic lesion often associated with noncirrhotic portal hypertension (PHT). We have noted that NRH and PHT are frequent occurrences in a colony of dogs with the genetic storage disease, mucopolysaccharidosis I (MPS-I). This observation provides the opportunity to study the histology and pathogenesis of NRH and noncirrhotic PHT in a new animal model. Thirteen of 32 dogs (41%) with MPS-I developed multiple portocaval shunts between 4 and 48 months of age that were grossly visible at necropsy. Seven of the 13 developed marked ascites, whereas all those without shunts and littermates (n = 24) heterozygous for the mutated alpha-L-iduronidase allele (carriers unaffected by the storage disease) did not. The large and medium-sized portal veins were widely patent without thrombosis or vascular malformations. Hepatic parenchymal fibrosis was absent or mild and did not correlate with shunt formation. All 32 livers had varying degrees of diffuse periportal hepatocellular hyperplasia with multifocal atrophy and compression of centrolobular cords (NRH) most prominent in dogs with shunts. Many small portal veins were reduced in diameter or absent, especially in animals with shunts. Noncirrhotic PHT and NRH appear to be related to the obliteration of small portal veins in these dogs, but the pathogenesis of this vascular change remains unknown.
Extensive myocardial fiber disarray in aortic and pulmonary atresia. Relevance to hypertrophic cardiomyopathy.
Authors: B H Bulkley, B D'Amico, A L Taylor
Journal: Circulation (1983)

Myocardial fiber disarray is a distinctive histopathologic finding seen in asymmetric hypertrophic cardiomyopathy. We studied 14 hearts with aortic atresia and intact interventricular septum, six hearts with pulmonic atresia and intact interventricular septum, eight normal infant hearts matched for age of the study hearts, and one nonadult heart with hypertrophic cardiomyopathy and asymmetric hypertrophy and quantitatively analyzed tissue sections through both ventricles and the septum. Normal hearts had an average overall fiber disarray of 8.7% (range 3.8-17%) of the left ventricle including septum. Hearts with pulmonary atresia had an overall disarray of 70.4% (range 13-97%) of the entire right ventricle, and those with aortic atresia 62.1% (range 26-97%) of the left ventricle. The one infant heart with hypertrophic cardiomyopathy showed 15.5% disorder of the left ventricular free wall, 75% disorder of the septum and 47% overall myocardial fiber disarray. Thus, while quantitative criterion distinguished normal from abnormal hearts, they did not distinguish among the various pathologic states. Although extensive myocardial fiber disarray is not exclusive to, or pathognomonic of, hypertrophic cardiomyopathy, it is a useful finding taken in the context of the overall disease. The sensitivity and specificity of this isolated morphologic observation as an indication of hypertrophic cardiomyopathy may be misleading.
Croup — The Bark Is Worse Than the Bite
Authors: Perri Klass
Journal: New England Journal of Medicine (2004)

It is a cliché of primary care pediatrics: on call in the winter, you find yourself on the telephone with a worried parent who is anxiously trying to describe a baby's symptoms — and then, in the background, you hear the barking. I regularly joke with other pediatricians about the things we're asked to diagnose over the phone (“Could you just hold the receiver right up to the rash?”), but croup is an easy long-distance diagnosis. Parents call at night because croup gets worse at night. The barking cough can be terrifying to a parent who hasn't heard it before, . . .
Accidental Intra-Arterial Injection of Ether
Authors: Harold King
Journal: JAMA (1963)

MEASUREMENT of the venous circulation time is frequently performed as a part of a thorough evaluation of a patient's cardiac status. It is generally considered a simple, routine test and is often done in the physician's office. Ether is one of the many substances which has been recommended for this measurement. Its use has been considered innocuous, and toxic effects are not mentioned in standard textbooks of medicine and cardiology. The purpose of this report is to point out that ether may be hazardous if it is accidentally introduced into an artery.  Report of a Case  The patient was a 64-yr-old male. The day prior to hospitalization an attempt was made to measure venous circulation time using 1/2 ml of ether in 1/2 ml of saline administered into what was thought to be the antecubital vein. Immediately following the injection, the patient experienced severe burning pain in his arm and
Democratization in the Mental Hospital as a Therapeutic Vehicle
Authors: P. Bierenbroodspot
Journal: Psychotherapy and Psychosomatics (1972)

Psychotherapy as such has two aspects, a reality (here-and-now) aspect and a transference (distortion-of-reality) aspect, which, in the clinical setting, should be distinguished even more clearly than is done in individual therapy. The reality aspect, crystallized in the process of decision-making, is made more explicit when democratization (a process of delegation of power and responsibility) is introduced into the mental hospital. Problems concerning various types of resistance to democratization (descended from patients, staff or the clinical setting <i>per se</i>) are further discussed.
Public Hospitals: Doing What Everyone Wants Done but Few Others Wish to Do
Authors: Emily Friedman
Journal: JAMA (1987)

AMERICAN PUBLIC HOSPITALS —that is, institutions owned by federal, state, or local governments in the United States—today present a series of contradictions. Among urban public hospitals are several of the oldest health care institutions on the continent, yet that heritage often earns them little respect. Public hospitals in many cities are filled to capacity and suffering severe financial and clinical problems as a result; but in rural areas, lack of business threatens many government health care institutions. Residencies in public teaching hospitals are often eagerly sought; yet many physicians who trained in such residencies hesitate to refer their patients to these hospitals. Several public hospitals —Cook County Hospital, Chicago; Bellevue Hospital Center, New York City; Boston City Hospital—are legendary in medical history; but the physical plants of the Boston and Chicago hospitals (among others) are sadly deteriorated. The demise of the public hospital was widely predicted after the passage of
Risk Factors for Recurrence and Unfavorable Prognosis in Patients with Stage I Non-small Cell Lung Cancer and a Tumor Diameter of 20 mm or Less
Authors: Naruyuki Kobayashi, Shinichi Toyooka, Junichi Soh, Kouichi Ichimura, Hiroyuki Yanai, Hiroshi Suehisa, Shuji Ichihara, Masaomi Yamane, Motoi Aoe, Yoshifumi Sano, Hiroshi Date
Journal: Journal of Thoracic Oncology (2007)
Public Access to Death Certificates
Authors: Donald A. Redelmeier
Journal: Annals of Internal Medicine (1989)

Letters and Corrections1 July 1989Public Access to Death CertificatesDonald A. Redelmeier, MDDonald A. Redelmeier, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-111-1-92_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: The article by Burnum (1) provides a valuable cautionary note for those using the medical record as a source of information. However, the recommendation to restore the integrity of the chart by regulations restricting public view may conflict with the current attitudes of physicians. Does improving accuracy dominate other issues? To study this question, I surveyed two groups of internists working in private practice to assess their preferences regarding sensitive medical information.The first questionnaire asked whether public access to death certificates should be restricted in order to protect confidentiality. The second questionnaire asked what should be...Reference1. Burnum J. The misinformation era: the fall of the medical record. Ann Intern Med. 1989;110:482-4. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Stanford University Medical School Stanford, CA 94305-5091 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDeath and aids: A review of the medico-legal literature 1 July 1989Volume 111, Issue 1Page: 92-92KeywordsChartsQuestionnaires Issue Published: 1 July 1989 PDF DownloadLoading ...
Herpes Encephalitis and Pregnancy
Authors: Edward J. Lynn
Journal: JAMA (1978)

<h3>To the Editor.—</h3> There is a dearth of follow-up data about women who have suffered the loss of an infant stricken with herpes encephalitis. Nahmias and Visintine<sup>1</sup>state, "Although theoretically possible, according to present knowledge, no instance has been reported in which HSV [herpes simplex virus] infection occurred in more than one offspring of successive pregnancies in the same mother." A review of the literature failed to show any documentation of normal offspring in successive pregnancies. Correspondence with a number of neonatologists engaged in research in the field, obstetricians, and infectious disease experts has been essentially nonproductive. Four personal leads have hinted at some of the difficulties: sterilization procedure, two divorces, and decision not to get pregnant again. Exploration by a colleague unearthed a case of a woman who lost a child in 1958, had two subsequent cesarean section deliveries, but was lost to follow-up. The loss of an
Motor Vehicles or Firearms: Which Takes a Heavier Toll?
Authors: Garen Wintemute
Journal: JAMA (1993)

To the Editor.  —The leading causes of traumatic death in the United States are motor vehicles and firearms. In the former case, a major national effort to reduce the incidence and severity of injuries has had impressive results. From a high of 27.7 per 100 000 persons in 1969, the annual rate of motor vehicle-related deaths has declined 36% to an estimated 17.8 per 100 000 persons in 1991 (provisional data, National Center for Health Statistics)—lower than at any time since the early 1940s. 1 No such injury prevention program has addressed firearm injuries, and the incidence of these has remained relatively stable at historically high levels. 2   For some years I have been suggesting that we may see firearms displace motor vehicles as the nation's leading cause of traumatic death. The news that this has already occurred in Texas and Louisiana 3 prompted this attempt to predict when the
Factors Influencing Return to Work
Authors: R. Sanders
Journal: BMJ (1971)

the fact that they are hospital-based in decid- ing which arrangement is the better.But I am certain of one thing: that there is need for experiment and that in this most important work policy based purely on depart- mental decree is not good enough.If, in the broadest sense, we are to get value for money this airing of the resettlement of the disabled should be followed by a planned comparative study.-I am, etc.,
Tobacco Use by American Indian Youth
Authors: Michael S. Moncher, Steven P. Schinke, Gary W. Holden, Shirley Aragon
Journal: JAMA (1989)

<h3>To the Editor.—</h3> Earlier we reported data detailing the health effects of smokeless tobacco use by adolescents.<sup>1</sup>In the course of our current research, we studied tobacco use rates among Indian youths from Colorado, North and South Dakota, Idaho, Montana, and Oklahoma. We believe that the disquieting results bear reporting. <h3>Study. —</h3> Our cross-tribal sample included 1150 youths (93% Indian; 48.1% female; mean age, 10.3 years). Informed consent was obtained prior to assessment of this school-based sample of preadolescents. Responding to 126 items on a confidential questionnaire, children reported their lifetime prevalence of smoked and smokeless tobacco and their use during the prior 7 days and 24 hours. The privately completed questionnaires were sealed and deposited into a collection box. Analysis of self-reported tobacco use, by sex, focused on rates of lifetime prevalence, recent incidence, and peer use (Table). High rates of tobacco use are evident in the sample
Oxidative metabolism in guinea pig ventricular myocytes protected from proteolytic enzyme activity
Authors: L. E BAILEY, H. CARLOS, A. AMIAN, K. E T MOON
Journal: Cardiovascular Research (1987)

Journal Article Oxidative metabolism in guinea pig ventricular myocytes protected from proteolytic enzyme activity Get access LESLIE E BAILEY, LESLIE E BAILEY From the Department of Pharmacology, School of Medicine, University of Hawaii, Honolulu, Hawaii, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar HELEN CARLOS, HELEN CARLOS From the Department of Pharmacology, School of Medicine, University of Hawaii, Honolulu, Hawaii, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar ARNIE AMIAN, ARNIE AMIAN From the Department of Pharmacology, School of Medicine, University of Hawaii, Honolulu, Hawaii, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar KARL E T MOON KARL E T MOON From the Department of Pharmacology, School of Medicine, University of Hawaii, Honolulu, Hawaii, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 21, Issue 7, July 1987, Pages 481–488, https://doi.org/10.1093/cvr/21.7.481 Published: 01 July 1987 Article history Received: 21 August 1986 Accepted: 16 December 1986 Published: 01 July 1987
Surgical ablation of atrial fibrillation: Clinical results and predictors of success
Authors: Mauricio Garrido, Mathew R. Williams, Deon W. Vigilance, Jennifer Casher, Ann Zeidner, Aftab R. Kherani, Jeffrey A. Morgan, Hadar Hermoni, Yoshifumi Naka, Craig R. Smith, Mehmet C. Oz, Michael Argenziano
Journal: Journal of the American College of Cardiology (2003)
Reduction of nitric oxide displacing albumin bound toxins by extracorporeal liver support — new therapy for hyperdynamic circulation?
Authors: J. Stange, S. Mitzner, S. Klammt, P. Peszynski, J. Freytag, J. Hentschel, M. Schulz, J. Loock, R. Schmidt
Journal: Journal of Hepatology (2000)
Correction: Ciba's Rifampin
Authors: DANIEL R. SHIELDS
Journal: Annals of Internal Medicine (1971)

Letters, Comments, and Corrections1 December 1971Correction: Ciba's RifampinDANIEL R. SHIELDS, M.D.DANIEL R. SHIELDS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-6-977 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the article "Rifampin: Characteristics and Role in the Chemotherapy of Tuberculosis" by Drs. Arthur Vall-Spinosa and T. William Lester in the May 1971 issue, the authors mentioned that both Dow and Ciba are distributing rifampin under the tradename Rifadin.Dow's tradename is Rifadin, but Ciba's tradename is Rimactane.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Research Department Medical Division Ciba Pharmaceutical Co. Summit, N.J. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPreparation of a new 1,2,3-trithiolane, trans-9,10,11-trithiabicyclo[6.3.0]undecane, and its oxidation reactions 1 December 1971Volume 75, Issue 6Page: 977-977KeywordsChemotherapy Issue Published: 1 December 1971 PDF DownloadLoading ...