Efficacy of Nitroglycerin Patches: Fact or Fancy?
Authors: JOHN O. PARKER
Journal: Annals of Internal Medicine (1985)

Editorials1 April 1985Efficacy of Nitroglycerin Patches: Fact or Fancy?JOHN O. PARKER, M.D.JOHN O. PARKER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-4-548 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe organic nitrates have been the most commonly used agents in the management of patients with angina pectoris. Although various beta-adrenoreceptor blocking agents and calcium-entry blocking drugs are now available, the nitrates remain important in the prophylaxis of angina and are the drugs of choice in the treatment of spontaneous or exercise-induced angina pectoris. When administered orally, the organic nitrates are considered to provide protection for periods of several hours and are usually taken four times daily. Recent studies, however, have shown the development of tolerance to the antianginal effects of the orally administered organic nitrates (1-3). 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Author, Article, and Disclosure InformationAffiliations: Queen's University Kingston, Ontario Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByToxicological Profile for Otto Fuels IITransdermal glyceryl trinitrate (nitroglycerin) in healthy persons: acute effects on skin temperature and hemodynamic orthostatic responseLong-term efficacy of continuous and intermittent use of transdermal nitroglycerin in stable angina pectorisNitrate: Warum und wie sie heute eingesetzt werden solltenNitrates: Why and how should they be used today?Effect of cutaneous nitroglycerin patches on coronary artery diameter: Issues concerning development of toleranceReplyPharmacologic Treatment of Angina: Nitrate ToleranceSustained hemodynamic effects with therapeutic doses of intravenous nitroglycerin in congestive heart failureInterdependence of pharmacologically-induced and endothelium-mediated coronary vasodilation in antianginal therapyAcute and sustained antianginal effects of nitroglycerin patches: Objective evaluation with training-effect-eliminated exercise performance indexEfficacy of a new transdermal nitroglycerin patch (deponit 10) for stable angina pectorisNitratesNitrate Therapy in Stable Angina PectorisEffect of Intervals between Doses on the Development of Tolerance to Isosorbide DinitrateLong-term nitroglycerin treatment: effect on direct and endothelium-mediated large coronary artery dilation in conscious dogs.Clinical Experience With a Transdermal Nitroglycerin SystemThe controversy over transdermal nitroglycerin: An updateA multicenter trial of transdermal nitroglycerin in exercise-induced angina: Individual antianginal response after repeated administrationInfluence of Transdermal Nitrates on Exercise Capacity in Patients with Stable AnginaTransdermal Nitroglycerin and Nitrate ToleranceJONATHAN ABRAMS, M.D.Update on transdermal nitroglycerin: An overview 1 April 1985Volume 102, Issue 4Page: 548-550KeywordsAnginaDrugsNitratesProphylaxis Issue Published: 1 April 1985 PDF DownloadLoading ...