tbuckley/cabot-search huggingface dataset:
Abstract 16291: Impact of Left Ventricular Hypertrophy Regression on Cardiovascular Outcomes. A Meta-Analysis
Authors: Pierluigi Costanzo, Stefania Paolillo, Gianluigi Savarese, Fabio Marsico, Paolo Cesarano, Antonio Marzano, Enrico Vassallo, Pasquale Perrone-Filardi
Journal: Circulation (2010)

Introduction:  Several clinical studies showed that left ventricular hypertrophy (LVH) regression is associated with a reduced risk of cardiovascular events. However, to date there is no meta-analysis putting in direct relationship the extent of LVH changes and cardiovascular outcomes. We performed a metaregression analysis assessing and quantifying the relationship between LVH regression and a composite cardiovascular outcome.   Methods:  MEDLINE and the Cochrane Database were searched for articles published until May 2010. All randomized trials assessing LVH at baseline, at end of follow-up and reporting clinical end points were included. Two reviewers independently retrieved, reviewed and extracted data. Discrepancies were resolved by consensus. A weighted random-effect meta-regression analysis was performed to test the relationship between LVH changes and outcomes. Odds Ratios (OR) and 95% Confidence Intervals (CI) were calculated with a fixed-effects or random effects model. The influence of baseline patients9 characteristics, LVH at baseline, follow up was also explored.   Results:  Six trials were included for a total of 2144 patients. By pooling all trials included in the meta-analysis, the risk for the composite outcome was significantly reduced by treatment vs control (OR 0.59; 95% CI 0.44 to 0.78; comparison p   Conclusion:  As also demonstrated by single randomized clinical trials, in a pooled analysis LVH regression predict CV risk reduction. Therefore, our results suggest that its role in tracking cardiovascular risk modification is valid.
UK government changes yellow card scheme
Authors: Jenny Blythe
Journal: BMJ (2000)

The UK Medicines Control Agency has announced changes to the yellow card scheme, through which doctors report suspected adverse drug reactions.

The yellow cards will no longer require a patient's personal details, such as name and address and date of birth. Instead, only the patient's initials and age at time of reaction will be requested, along with a local reference code. This reference code can be either a hospital …
Value of adding treatment with lyophilized bacterial lysates in reducing COPD exacerbations in COPD patients risk group C and D
Authors: Anita-Maria Genda, Lavinia Davidescu, Ruxandra Ulmeanu, Monica Ilisie
Journal: European Respiratory Journal (2014)

Background: An increased frequency of exacerbations in COPD is associated with rapid decline of lung function, while the mechanism of exacerbations are not clear yet. By including in the treatment immunostimulant agents like lyophilized bacterial lysates, we can reduce exacerbations, especially in COPD patients risk groups C and D.

Aim:To evaluate the value of adding in the treatment lyophilized bacterial lysates in reducing exacerbations in COPD patients risk groups C and D.

Methods: From January to December 2013 were studied 41 patients with COPD groups C and D, admitted in the Municipal Clinic Hospital Oradea,for severe exacerbations.We compared COPD patients at risk groups C and D who had added lyophilized bacterial lysates to their standard medication, to patients with COPD group C and D without immunostimulant treatment added on. We analysed the following data: age, gender, smoking history (PackYear), number of exacerbations/year, number of days of hospitalization, spirometry parameters (FEV1, FEV1/FVC).

Results:Of all 41 studied patients, 43,9 % (lot nr I.) were treated with lyophilized bacterial extract and 56,1 % (lot nr. II) had no immunostimulant treatment.The first lot of patients had 2.11 exacerbation/year,while the second category had 2,8 exacerbations/year. Moreover, patients from first lot had less days of hospitalization (11.07 days) as compared to patients from second lot (17.1 days), hence a lowering of 35,3% in the number of days of hospitalization.

Conclusions:The treatment with lyophilized bacterial lyzates decreased significantly the number of exacerbations/year and days of hospitalization in patients with COPD risk groups C and D.
Abstract 20536: ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration (ALLSTAR): the One Year Phase I Results
Authors: Raj Makkar, Richard Schatz, Jay Traverse, Andrew Hamer, Katherine Beattie, Rachel R Smith, Francie Kivel, Linda Marbán, Eduardo Marbán, Timothy D Henry
Journal: Circulation (2014)

Introduction: In CADUCEUS, autologous cardiosphere-derived cells decreased infarct size and increased viable tissue in post-myocardial infarction (MI) subject s. Hypothesis: The first-in-human Phase I ALLSTAR trial was designed to test the safety and feasibility of intracoronary infusion of allogeneic cardiosphere-derived cells (CAP-1002) in patients with an anterior MI, within the prior 12 months with a scar size &gt;15% by Magnetic Resonance Imaging (MRI). Methods: A total of 14 adult subjects (mean age = 55.6 yr; range 40-66 years) with a recent (28 - 90 days; n=9) or chronic (91-365 days; n=5) anterior MI (mean infarct size 25.4%; range 15.3% - 32.7%) and LV dysfunction (mean LVEF 42%; range 26.7% - 55.1%) were prospectively enrolled and infused with CAP-1002 (n=4 at 12.5M dose; n=10 at 25M dose) via stop-flow intracoronary infusion. Primary safety endpoints were: MACE events (recurrent MI, hospitalization or ER treatment for heart failure, Left Ventricular Assist Device placement or heart transplantation), acute myocarditis, death due to arrhythmias or unwitnessed death. Humoral and cellular immunologic responses were assessed via single antigen bead and ELISpot assays. Results: No pre-specified safety endpoint occurred. Only two adverse events were treatment-related, both transient hypotension related to nitroglycerin. There were no clinically significant rises in peri-procedural cardiac enzymes. Donor specific antibodies (DSAs) were present in four subjects prior to infusion; one resolved and three presistent at 6 months of follow up. De novo DSA’s developed in four subjects, three resolved during follow up and one persisted at 6 months of follow up. All DSA levels were low (MFI&lt;5000). ELISpot revealed no de novo cellular immune responses. One year follow-up safety data as well as full 6 month and available 12 month MRI results on scar size and LVEF will be presented. Conclusions: Intracoronary infusion of allogeneic cardiosphere-derived cells (CAP-1002) appears to be safe and feasible. On the basis of the Phase 1 findings, the ALLSTAR trial has proceeded to a Phase II randomized, double-blind trial, powered to assess reduction of scar size by MRI.
Association of Severe Disc Degeneration With All‐Cause Mortality and Abdominal Aortic Calcification Assessed Prospectively in Older Men: Findings of a Single‐Center Prospective Study of Osteoporosis in Men
Authors: Charline Estublier, Roland Chapurlat, Pawel Szulc
Journal: Arthritis & Rheumatology (2015)

To assess the association of disc degeneration with all-cause mortality and with the severity and rate of progression of abdominal aortic calcification (AAC) in older men.Men >50 years of age (n = 766) underwent lateral spine radiography and blood collection and were monitored prospectively. We assessed the association of disc degeneration with all-cause mortality (at 10 years), AAC severity (at baseline), and AAC progression (at 7.5 years).After adjustment for confounders, including AAC, the total overall grade score for AAC predicted all-cause mortality (hazard ratio [HR] 1.20 per SD increase [95% confidence interval (95% CI) 1.01-1.43]). The highest tertile of the total overall grade score was associated with higher mortality rates (39.3/1,000 person-years for a score of >8 versus 20.9/1,000 person-years for a score of 0-8; adjusted HR 1.47 [95% CI 1.05-2.06]). The odds of severe AAC (score of >5) increased with the total disc space narrowing score (adjusted HR 1.44 per SD [95% CI 1.11-1.87]). The highest tertile of the total disc space narrowing score was associated with higher odds of severe AAC (adjusted HR 2.42 versus the lowest tertile [95% CI 1.24-4.73]). The probability of long-term AAC stability decreased with an increasing total osteophyte score (adjusted HR 0.66 per SD [95% CI 0.49-0.88]). The highest tertile of the total osteophyte score was associated with a lower probability of AAC stability (adjusted HR 0.35 versus the lowest tertile [95% CI 0.18-0.71]).Older men with severe disc degeneration have greater AAC severity, faster AAC progression, and higher all-cause mortality rates.
Comparison of the impact of environmental stress on male and female skin
Authors: J.E. Oblong
Journal: British Journal of Dermatology (2012)

Past research on understanding gender differences of skin biology and its response to environmental insults has focused on morphological and gross physiological comparisons. In general it has been found that male skin has a greater susceptibility to being negatively impacted by environmental stressors, in particular ultraviolet radiation. These noted differences in response to environmental insults are probably due to a combination of underlying biologically based differences and variable sun‐protection and skin‐care product usage between genders. Overall, published data support the hypothesis that male facial skin undergoes significant challenges from environmental insults that lead to a more damaged condition compared with female skin. These changes occur both from acute insults and from the impact of cumulative chronic exposure. Appropriate sun protection should be viewed as an important step in male skin care and grooming habits.
719. E1-Deleted Adenoviral Vectors Persist in Activated Lymphocytes and Cause Continued Transgene Expression and Stimulation of CD8+ Effector T Cells
Authors: J Fitzgerald, A Reyes-Sandoval, N Tatsis, S E Hensley, Ertl Hcj.
Journal: Molecular Therapy (2004)

Top of pageAbstract
As initial attempts to develop a vaccine that induces broadly cross-reactive neutralizing antibodies to the human immunodeficiency virus (HIV)-1 have failed, current vaccine approaches are focused on induction of cell-mediated immune responses, especially CD8+ T cells, against more conserved internal proteins of HIV-1. The differentiation pathway of antigen-induced memory CD8+ T cells has raised doubts about the usefulness of vaccines that target their induction, a concern substantiated by an experiment of nature, which showed in African prostitutes a link between resistance to infection and constant exposure to antigen. This in turn predicts that HIV-1 vaccines that aim to induce memory CD8+ T cells may have limited efficacy in humans. We tested a new vaccine platform based on E1-deleted adenoviral vectors derived from chimpanzee serotypes expressing gag of HIV-1 for induction of gag-specific CD8+ T cells in mice. A single administration of the vaccines resulted in exceptionally transgene product-specific CD8+ T cell frequencies, which initially declined after 2–3 weeks and then resurged suggestive of an internal booster effect due to continued or renewed production of gag. Indeed gag transcripts could be detected in lymphatic tissues for over a year after a single administration of the replication-defective adenoviral vectors. Interestingly, transcripts were preferentially expressed by activated gag-specific T cells. These results put forward a novel vaccine concept based on constructs that achieve persistent transgene product expression and thus maintain high frequencies of specific CD8+ T cells which may be superior in providing an immediate line of defense against an invading pathogen compared to resting memory CD8+ T cells.
THE FORMOL-GEL REACTION IN BLOOD OF PATIENTS WITH CHRONIC RHEUMATOID DISEASES
Authors: C. Wesler Scull, Ralph Pemberton
Journal: Annals of Internal Medicine (1940)

Article1 December 1940THE FORMOL-GEL REACTION IN BLOOD OF PATIENTS WITH CHRONIC RHEUMATOID DISEASESC. WESLER SCULL, PH.D., RALPH PEMBERTON, M.D., F.A.C.P.C. WESLER SCULL, PH.D.Search for more papers by this author, RALPH PEMBERTON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-6-993 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONStudies conducted in this laboratory on the protein fractions in the sera of arthritics clearly show that moderate and sometimes marked hyperglobulinemia is a significant feature among certain classes of arthritic subjects.6Associated with the increase in serum globulin there is an elevation in the fibrinogen of the corresponding plasma. These results are in substantial agreement with observations made by Aldred-Brown and Monroe1and by Davis.3Recognition of the presence of these features in a given case is of practical importance, inasmuch as an elevation in the level of the globulin or fibrinogen in the blood shows the presence...Bibliography1. ALDRED-BROWNMONROE GRJM: The plasma protein and non-protein nitrogen and sedimentation rate in chronic rheumatic disorders, Quart. Jr. Med., 1935, iv, 269-277. Google Scholar2. BING J: The formol-gel reaction and other globulin reactions, Acta med. Scand., 1937, xci, 336-356. Google Scholar3. DAVIS JS: Protein studies in atrophic (rheumatoid) and hypertrophic arthritis, Jr. Lab. and Clin. Med., 1936, xxi, 478-490. Google Scholar4. GIBSONKERSLEY HJGD: Gout, Med. Press and Circ., 1934, cxcvi, 5164. Google Scholar5. GIBSONRICHARDSON HJEW: The formol-gel test (aldehyde reaction) in chronic rheumatism, Acta Rheumatol., 1938, x, 30-33. Google Scholar6. SCULLBACHPEMBERTON CWTFR: The serum proteins in arthritis, ANN. INT. MED., 1939, xii, 1463-1472. Google Scholar7. WISEGUTMAN CRAB: The formol-gel reaction: a convenient preliminary test for hyperglobulinemia, Am. Jr. Med. Sci., 1937, cxciv, 263-270. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication June 18, 1940.From the Abington Memorial Hospital, Abington, Pa.The expenses of this investigation were defrayed in part by a grant in memory of Alexander B. Coxe. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Formol-Gel Test on Plasma and Serum in Rheumatic Cases: Correlation Studies and a Suggestion that Non-Rouleaux-Forming Pathological Globulins may be of Significance in Rheumatism 1 December 1940Volume 14, Issue 6Page: 993-1000KeywordsBloodBlood plasmaFibrinogenGlobulinsHyperglobulinemiaMemoryPlasma proteinsResearch laboratoriesSerum proteins ePublished: 1 December 2008 Issue Published: 1 December 1940 PDF downloadLoading ...
Abstract 4084: NKG2D receptor activation of mTOR and NFκB enhances antitumor immunity in effector CD8+ T cells
Authors: Emily Whitman, Amorette E. Barber
Journal: Cancer Research (2014)

Abstract To induce strong anti-tumor immune responses, naïve CD8+ T cells require stimulation through the TCR and costimulatory receptors. Each costimulatory molecule can have a unique effect on the function of T cells due to differential activation of downstream signaling pathways and gene expression. However, the effect of stimulating costimulatory receptors on activated T cells is still unclear. One costimulation receptor that is likely to be engaged in the tumor microenvironment is NKG2D since the ligands for this receptor are expressed on over 80% of tumors. In order to determine how activation of costimulatory receptors in the tumor microenvironment affects CD8+ T cell functions, this study investigated the differential activation of signaling pathways by two costimulatory receptors, CD28 and NKG2D. Specifically, this study focused on the activation of mTORC1 and mTORC2 along with NFκB, all of which have been shown to have important roles in anti-tumor functions of CD8+ T cells. Stimulation through the CD3 and NKG2D receptors differentially activated the mTOR and NFκB pathways compared to the other receptors in our study. Activation of CD8+ T cells through CD3 and NKG2D lead to increased phosphorylation of signal transduction pathway members upstream of mTOR, including AKT, p70 S6K, and GSK3β. Also, expression of genes upstream and downstream of mTORC1 and mTORC2 were differentially activated after stimulation through NKG2D, indicating that activation of mTOR pathways are altered after CD3/NKG2D stimulation as compared to stimulation through CD3 or CD3/CD28. In addition, IKKα, IκBα, and NFκB phosphorylation and IκBα degradation was increased after CD3/NKG2D stimulation. This increased activation of the NFκB pathway also lead to increased gene expression and secretion of pro-inflammatory cytokines, including IFN-alpha and IFN-gamma, and decreased gene expression and secretion of anti-inflammatory cytokines, including IL-10 and VEGF-alpha. Together, these data show that stimulation through NKG2D leads to the differential activation of signaling pathways and alters the anti-tumor functions of effector CD8+ T cells. Citation Format: Emily Whitman, Amorette E. Barber. NKG2D receptor activation of mTOR and NFκB enhances antitumor immunity in effector CD8+ T cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4084. doi:10.1158/1538-7445.AM2014-4084
Epidemiology of Pneumocystis carinii pneumonia in southern Spain
Authors: E.J. Calderón, J.M. Varela, F.J. Medrano, V. Nieto, C. González-Becerra, N. Respaldiza, C. De la Horra, M.A. Montes-Cano, E. Vigil, M.A. González de la Puente, J.A. Cuello
Journal: Clinical Microbiology and Infection (2004)
Electronic fetal monitoring
Authors: R. Goddard
Journal: BMJ (2001)

Papers p 1457 

Electronic fetal monitoring with the cardiotocograph is standard practice during labour in most obstetric units in the United Kingdom. The technique was introduced as a screening test in the 1970s in the belief that it would improve the detection of fetal hypoxaemia and reduce cerebral palsy and perinatal mortality, particularly in high risk pregnancies. Early retrospective observational studies supported the view that it was superior to intermittent auscultation using either a Pinard stethoscope or a hand held doppler ultrasound device.1 Its use spread rapidly from high risk to low risk pregnancies where the fetus is at least risk from hypoxic events in labour. Was this spread necessary or wise?

By the 1990s systematic reviews of randomised controlled trials of electronic fetal monitoring versus intermittent auscultation during labour had shown no effect on neonatal outcomes such as metabolic acidosis at birth, low Apgar scores or admissions to neonatal intensive care.2–4 An increase in neonatal seizures was seen in the group with intermittent auscultation but no long term increase in neurological problems.5

Electronic fetal monitoring did, however, …
Quality of Care and Satisfaction Among Patients Isolated for Infection Control
Authors: Stephen G. Weber, Trish M. Perl, Sara E. Cosgrove
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FDA Approves Ultrasound Fibroid Therapy
Authors: Sarah Ringold
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The serological prevalence of Coxiella burnetii antibodies in sheep and goats in northern Greece
Authors: M. Pape, E.G. Bouzalas, G.S. Koptopoulos, K. Mandraveli, M. Arvanitidou-Vagiona, P. Nikolaidis, St. Alexiou-Daniel
Journal: Clinical Microbiology and Infection (2009)
Abstract 17691: Inhibition of Na/K-ATPase Signaling Regulates Cardiac C-Kit Cell Expression in Mice with Chronic Kidney Dysfunction
Authors: Christopher A Drummond, Huilin Shi, Steven T Haller, Jiang Liu, Zijian Xie, Christopher J Cooper, Joseph I Shapiro, Jiang Tian
Journal: Circulation (2014)

Introduction: Na/K-ATPase (NKA) has been shown to regulate cell survival and causes cardiac remodeling through its signaling pathway. Our previous publications have shown that genetic reduction of NKA attenuates cell survival signaling, potentiates myocyte apoptosis, and increases c-kit cell number in mice receiving 5/6th partial nephrectomy (PNx) surgery. Hypothesis: To test if inhibition of NKA signaling increases cardiac cell death and triggers activation of c-kit cells, we subjected heterozygous mice with genetic reduction of the NKA α1 subunit (α1+/-) and their wild type (WT) litter mates to the PNx surgical model of chronic kidney disease (CKD). Methods: Twelve weeks after PNx surgery, these mice were injected biweekly with pNaKtide, a peptide that specifically inhibits NKA related Src signaling, at a dose of 25mg/kg. Mice injected with same volume of saline were used as controls. Mice were then sacrificed 16 weeks post PNx surgery. Results: The experimental results showed that PNx induces significa...