STUDIES ON EXPERIMENTAL PHOSGENE POISONING V. INFUSIONS IN THE TREATMENT OF EXPERIMENTAL PHOSGENE POISONING
Authors: H D BRUNER, M H GIBBON
Journal: Annals of Internal Medicine (1948)

Article1 June 1948STUDIES ON EXPERIMENTAL PHOSGENE POISONING V. INFUSIONS IN THE TREATMENT OF EXPERIMENTAL PHOSGENE POISONINGH. D. BRUNER, M.D., PH.D., MARY H. GIBBON, MILES D. MCCARTHY, PH.D., ROBERT D. BOCHE, PH.D., TIMOTHY R. TALBOT JR., M.D., JOHN S. LOCKWOOD, M.D., GEORGE B. SANDERS, M.D.H. D. BRUNER, M.D., PH.D.Search for more papers by this author, MARY H. GIBBONSearch for more papers by this author, MILES D. MCCARTHY, PH.D.Search for more papers by this author, ROBERT D. BOCHE, PH.D.Search for more papers by this author, TIMOTHY R. TALBOT JR., M.D.Search for more papers by this author, JOHN S. LOCKWOOD, M.D.Search for more papers by this author, GEORGE B. SANDERS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-6-1125 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFollowing exposure to phosgene, the transudation ofplasmainto the pulmonary alveoli leads to two functional derangements, either of which is potentially lethal.1, 2, 3One is the obstruction to pulmonary gaseous exchange due to the physical presence of this fluid in the alveoli and eventually in the bronchioles; the development and magnitude of this lesion can be evaluated by observing the arterial oxygen saturation. The second is loss of circulating plasma volume which results in a hemodynamic state very similar to secondary or surgical shock. The accompanying hemoconcentration may be so extreme that the raised blood viscosity seriously impedes...Bibliography1. 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Oxygen therapy in phosgene-poisoned dogs and rats, Jr. Clin. Invest., 1947, xxvi, 936. CrossrefGoogle Scholar7. BOCHEBRUNERTALBOTMCCARTHYGIBBON RDHDTRMDMH: Studies on experimental phosgene poisoning: IV. The effect of "pressure breathing" on the pulmonary edema of phosgene poisoning, Am. Jr. Med. Sci., 1947, ccxiv, 612. CrossrefGoogle Scholar8. COURTICEFOSS FCGL: Acute phosgene poisoning: effects of plasma replacement, Lancet, 1946, ii, 670. CrossrefGoogle Scholar9. POWERSBEELER JLEC: A tentative national formulary monograph of pectin, Bull. Nat. Formulary Comm., 1940, ix, 24. Google Scholar10. KOOPFLETCHERRIEGELLOCKWOOD CEAGCJS: Gelatin as a plasma substitute, Surgery, 1944, xv, 839. Google Scholar11. MYLINWINTERNITZDE SÜTÖ-NAGY EMCGJ: Studies on therapy in traumatic shock, Am. Jr. Physiol., 1943, cxxxix, 313. CrossrefGoogle Scholar12. ONCLEYBROWN JLA: Personal communication, 1944. Google Scholar13. ETTINGERBERTRAMSAWYER GHAWMC: Personal communication, 1943. Google Scholar14. 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SANDERS, M.D.*Received for publication May 16, 1947.From the Harrison Department of Surgical Research, Schools of Medicine, University of Pennsylvania, Philadelphia.The work described in this paper was done under a contract recommended by the Committee on Medical Research Between the Office of Scientific Research and Development and the University of Pennsylvania.†Formerly Lieut. (MC), U.S.N.R. The Bureau of Medicine and Surgery, U. S. Navy, does not necessarily endorse the views or opinions which are expressed in this paper. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhosgene-Induced acute lung injury: Approaches for mechanism-based treatment strategiesPhosgene inhalation toxicity: Update on mechanisms and mechanism-based treatment strategiesPhosgene-induced lung edema: Comparison of clinical criteria for increased extravascular lung water content with postmortem lung gravimetry and lavage-protein in rats and dogsEffect of PEEP on phosgene-induced lung edema: Pilot study on dogs using protective ventilation strategiesSingle high-dose dexamethasone and sodium salicylate failed to attenuate phosgene-induced acute lung injury in ratsNovel Insights Into Phosgene-Induced Acute Lung Injury in Rats: Role of Dysregulated Cardiopulmonary Reflexes and Nitric Oxide in Lung Edema PathogenesisACUTE INJURIES TO THE LUNG 1 June 1948Volume 28, Issue 6 Page: 1125-1131 Keywords Alveoli Blood Blood plasma Bronchioles Hemodynamics Lesions Oxygen Plasma volume Shock Surgery ePublished: 1 December 2008 Issue Published: 1 June 1948 PDF downloadLoading ...