FATAL AGRANULOCYTOSIS FOLLOWING THE INTRAPERITONEAL IMPLANTATION OF SULFANILAMIDE CRYSTALS
Authors: William R. Arrowsmith, Barbara Binkley, Carl V. Moore
Journal: Annals of Internal Medicine (1944)

Case Reports1 August 1944FATAL AGRANULOCYTOSIS FOLLOWING THE INTRAPERITONEAL IMPLANTATION OF SULFANILAMIDE CRYSTALSWILLIAM R. ARROWSMITH, M.D., BARBARA BINKLEY, M.D., CARL V. MOORE, M.D., F.A.C.P.WILLIAM R. ARROWSMITH, M.D.Search for more papers by this author, BARBARA BINKLEY, M.D.Search for more papers by this author, CARL V. MOORE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-2-323 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptComparatively few severe toxic reactions have resulted from the local use of sulfonamide drugs, presumably because relatively small amounts are placed in the tissues and because excretion is prompt.1It has been demonstrated that with the dosages used in local application there is only temporary appearance of the drug in the blood.2, 3The few severe reactions which have been described relate chiefly to the production of hepatic damage. Watson and Spink4reported fatal hepatitis in two individuals who had received sulfanilamide by intra-peritoneal implantation, and Jackson and Coller3observed nine instances of jaundice in a group of 62 patients...Bibliography1. 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WEINER AL: Cutaneous hypersensitivity to topical application of sulfathiazole, Jr. Am. Med. Assoc., 1943, cxxi, 411-413. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Louis, Missouri*Received for publication May 2, 1943.From the Department of Internal Medicine and the Department of Pathology, Washington University Medical School, and from Barnes Hospital, St. Louis, Missouri.†Research Fellow of the American College of Physicians at the time these observations were made; now 1st Lt. MC, AUS. This article was completed before the author entered military service.‡We are indebted to Dr. Glover H. Copher for permission to report this case. 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