Hepatitis C Virus and Fulminant Hepatitis
Authors: James W. Mosley, Jorge Rakela
Journal: Annals of Internal Medicine (1991)

Letters15 December 1991Hepatitis C Virus and Fulminant HepatitisJames W. Mosley, MD, Jorge Rakela, MDJames W. Mosley, MDSearch for more papers by this author, Jorge Rakela, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-115-12-983_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors:The failure of Wright and coworkers (1) to find specific hepatitis C virus (HCV) sequences by reverse-transcription polymerase chain reaction in 15 patients with acute hepatic failure who were referred for liver transplantation is surprising. Unfortunately, the brevity of the report makes it difficult to evaluate the applicability of their results to other series. During the 1970s, the Acute Hepatic Failure Study Group (AHFSG) carried out two cooperative clinical trials of therapies for fulminant hepatitis at centers throughout the United States and Canada (2, 3). As new tests for etiologic agents have become available, we have repeatedly...References1. WrightHsuDoneganFeinstoneGreenbergRead THESHA. Hepatitis C virus not found in fulminant non-A, non-B hepatitis. Ann Intern Med. 1991;115:111-2. LinkGoogle Scholar2. . Failure of specific immunotherapy of fulminant type B hepatitis. Ann Intern Med. 1977;86:272-7. LinkGoogle Scholar3. Rakela J. A double-blinded, randomized trial of hydrocortisone in acute hepatic failure. Acute Hepatic Failure Study Group [Abstract]. Gastroenterology. 1979;76:1297. Google Scholar4. RakelaMosleyEdwardsGovindarajanAlpert JJVSE. A double-blinded, randomized trial of hydrocortisone in acute hepatic failure. The Acute Hepatic Failure Study Group. Dig Dis Sci. 1991;36:1223-8. CrossrefMedlineGoogle Scholar5. YanagiKanekoUnouraMurakamiKobayashiSugihara MSMSKJ. Hepatitis C virus in fulminant hepatic failure. N Engl J Med. 1991;324:1895-6. CrossrefMedlineGoogle Scholar1. O'GradyAlexanderHayllarWilliams JGKR. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology 1989;97:439-45. CrossrefMedlineGoogle Scholar2. YanagiKanekoUnouraMurakamaKobayashiSugihara MSMSKJ. Hepatitis C virus in fulminant hepatic failure. N Engl J Med. 1991;324:1895-6. CrossrefMedlineGoogle Scholar3. AlterPurcellShihMelpolderHoughtonChoo HRJJMQ. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. New Engl J Med. 1989;321:1494-500. CrossrefMedlineGoogle Scholar4. FerayGigouSamuelThiersBernauBismuth CMDVJH. Hepatitis C (HCV) RNA and hepatitis B (HBV) DNA in patients with fulminant hepatitis. Hepatology [Abstract]. 1991;14:330. Google Scholar1. WrightHsuDoneganFeinstoneGreenbergRead THESHA. Hepatitis C virus not found in fulminant non-A, non-B hepatitis. Ann Intern Med. 1991;115:111-2. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1991Volume 115, Issue 12Page: 983-985KeywordsAcute liver failureClinical trialsHepatitisHepatitis C virusLiver transplantationPolymerase chain reaction Issue Published: 15 December 1991 PDF downloadLoading ...