Postmenopausal Hormones and Glycemic Effects
Authors: John P. Girod, Daniel J. Brotman
Journal: Annals of Internal Medicine (2003)

Letters16 December 2003Postmenopausal Hormones and Glycemic EffectsJohn P. Girod, DO and Daniel J. Brotman, MDJohn P. Girod, DOFrom Cleveland Clinic Foundation, Cleveland, OH 44195.Search for more papers by this author and Daniel J. Brotman, MDFrom Cleveland Clinic Foundation, Cleveland, OH 44195.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-139-12-200312160-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Kanaya and colleagues (1) reported that HRT protected against the development of diabetes in postmenopausal women with coronary artery disease. The authors noted that women treated with HRT had small decreases in BMI, waist circumference, and waist-to-hip ratio compared with those assigned to placebo. These differences were all statistically significant, but the authors' statistical analysis suggested that the morphologic changes did not mediate the differences in glucose homeostasis (data not shown). However, we think that changes in body composition could still be related to the changes in glucose tolerance, especially since the authors did not directly measure ...References1. Kanaya AM, Herrington D, Vittinghoff E, Lin F, Grady D, Bittner V, . Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2003;138:1-9. [PMID: 12513038] LinkGoogle Scholar2. Dobs AS, Nguyen T, Pace C, Roberts CP. Differential effects of oral estrogen versus oral estrogen-androgen replacement therapy on body composition in postmenopausal women. J Clin Endocrinol Metab. 2002;87:1509-16. [PMID: 11932273] CrossrefMedlineGoogle Scholar3. Sorensen MB, Rosenfalck AM, Hojgaard L, Ottesen B. Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy. Obes Res. 2001;9:622-6. [PMID: 11595778] CrossrefMedlineGoogle Scholar4. Munoz J, Derstine A, Gower BA. Fat distribution and insulin sensitivity in postmenopausal women: influence of hormone replacement. Obes Res. 2002;10:424-31. [PMID: 12055317] CrossrefMedlineGoogle Scholar5. Mooy JM, Grootenhuis PA, de Vries H, Kostense PJ, Popp-Snijders C, Bouter LM, . Intra-individual variation of glucose, specific insulin and proinsulin concentrations measured by two oral glucose tolerance tests in a general Caucasian population: the Hoorn Study. Diabetologia. 1996;39:298-305. [PMID: 8721775] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Cleveland Clinic Foundation, Cleveland, OH 44195. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoGlycemic Effects of Postmenopausal Hormone Therapy: The Heart and Estrogen/progestin Replacement Study: A Randomized, Double-Blind, Placebo-Controlled Trial Alka M. Kanaya , David Herrington , Eric Vittinghoff , Feng Lin , Deborah Grady , Vera Bittner , Jane A. Cauley , and Elizabeth Barrett-Connor Postmenopausal Hormones and Glycemic Effects Aidan McElduff Postmenopausal Hormones and Glycemic Effects Alka M. Kanaya , David Herrington , and Elizabeth Barrett-Connor Postmenopausal Hormones and Glycemic Effects John V.L. Sheffield and Eric B. Larson Metrics 16 December 2003Volume 139, Issue 12Page: 1043KeywordsAdipose tissueBody mass indexFatsGlucoseGlucose toleranceHormonesInsulin resistanceObesityStable coronary artery diseaseStatistical data ePublished: 16 December 2003 Issue Published: 16 December 2003 Copyright & PermissionsCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...