tbuckley/cabot-search huggingface dataset:
Cholesteryl Ester Transfer Protein and Mortality in Patients Undergoing Coronary Angiography
Authors: Andreas Ritsch, Hubert Scharnagl, Philipp Eller, Ivan Tancevski, Kristina Duwensee, Egon Demetz, Anton Sandhofer, Bernhard O. Boehm, Bernhard R. Winkelmann, Josef R. Patsch, Winfried März
Journal: Circulation (2010)

The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still open to debate. In the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial, inhibition of CETP in patients with high cardiovascular risk was associated with increased high-density lipoprotein levels but increased risk of cardiovascular morbidity and mortality. In this report, we present a prospective observational study of patients referred to coronary angiography in which CETP was examined in relation to morbidity and mortality.CETP concentration was determined in 3256 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study who were referred to coronary angiography at baseline between 1997 and 2000. Median follow-up time was 7.75 years. Primary and secondary end points were cardiovascular and all-cause mortality, respectively. CETP levels were higher in women and lower in smokers, in diabetic patients, and in patients with unstable coronary artery disease, respectively. In addition, CETP levels were correlated negatively with high-sensitivity C-reactive protein and interleukin-6. After adjustment for age, sex, medication, coronary artery disease status, cardiovascular risk factors, and diabetes mellitus, the hazard ratio for death in the lowest CETP quartile was 1.33 (1.07 to 1.65; P=0.011) compared with patients in the highest CETP quartile. Corresponding hazard ratios for death in the second and third CETP quartiles were 1.17 (0.92 to 1.48; P=0.19) and 1.10 (0.86 to 1.39; P=0.46), respectively.We interpret our data to suggest that low endogenous CETP plasma levels per se are associated with increased cardiovascular and all-cause mortality, challenging the rationale of pharmacological CETP inhibition.
Immunotherapy in mantle cell lymphoma: Anti‐CD20‐based therapy and beyond
Authors: Yuhong Zhou, Liang Zhang, Jorge Romaguera, Kay Delasalle, Xiaohong Han, Xin Du, Larry Kwak, Qing Yi, Michael Wang
Journal: American Journal of Hematology (2007)

Abstract Mantle cell lymphoma (MCL), an aggressive non‐Hodgkin's lymphoma characterized by t(11; 14)(q13; q32) chromosomal translocation and overexpression of cyclin D1, has the worst prognosis among all lymphomas. Recent advances in biology, genetics, and immunology have supported the development of immunotherapy in MCL. Rituximab monotherapy in MCL has limited activity. It is more effective when used in combination with chemotherapy such as R‐CHOP, R‐hyperCVAD/MTX‐Ara‐C, or R‐FCM as front‐line or salvage therapy for mantle cell lymphoma. Maintenance with Rituximab was shown to prolong response duration. Although most results have suggested that combining autologous stem cell transplantation with Rituximab may lead to durable remission, the sample size was not sufficient to declare survival benefit. Anti‐CD20 radioimmunoconjugates (RICs) 90 Yttrium‐ibritumomab tiuxetan and 131 Iodine‐tositumomab have been used in mantle cell lymphoma even when patients are relatively resistant to Rituximab‐based therapy. Allogeneic stem cell transplantation is a treatment modality in advanced or relapsed MCL, particularly using reduced‐intensity conditioning. MCL may have high response rates and sustained remissions after donor lymphocyte infusion. Dendritic cells (DCs) fused with MCL cells for immunostimulation have preliminarily shown anti‐lymphoma effects as well. Idiotype vaccination in MCL patients following Rituximab‐containing chemotherapy induced tumor‐specific T‐cell immunity in the absence of B cells. Other immunotherapy, such as the combination of thalidomide with Rituximab, has shown substantial antitumor activity. A Phase I/II study is ongoing to determine the maximum tolerated dose (MTD) and the efficacy of lenalidomide in combination with Rituximab for relapsed/refractory MCL. This review summarizes the latest and exciting advances in MCL. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.
Synergistic effect of hypoxia and TNF-α on production of PAI-1 in human proximal renal tubular cells
Authors: Xuan Li, Hideki Kimura, Kiichi Hirota, Kenji Kasuno, Kunio Torii, Toshiharu Okada, Hisanori Kurooka, Yoshifumi Yokota, Haruyoshi Yoshida
Journal: Kidney International (2005)
Consultant contract fails to deliver expected benefits for patients
Authors: Lynn Eaton
Journal: BMJ (2006)

NHS consultants have done well out of their new contract, introduced in 2003, but there is little sign as yet of a positive outcome for patients, a report from the King's Fund has warned. The so called benefits realisation from the new deal—securing changes in working patterns that would improve services—remain to be seen, says the report.

The Department of Health has already admitted that the contract cost £90m (荤130m; $170m) more to implement than was planned, says the report. It shows how consultants' pay increased substantially in 2001-5, with starting salaries rising from £50 810 in 2001 to £69 298 in 2005.

The increased costs have put considerable …
Cysteamine therapy delays the progression of nephropathic cystinosis in late adolescents and adults
Authors: Albane Brodin-Sartorius, Marie-Josèphe Tête, Patrick Niaudet, Corinne Antignac, Geneviève Guest, Chris Ottolenghi, Marina Charbit, Dominique Moyse, Christophe Legendre, Philippe Lesavre, Pierre Cochat, Aude Servais
Journal: Kidney International (2011)
Effect of dexfenfluramine on fat mass distribution in a high-fat rat model
Authors: M. Rebuffé-Scrive, C. DePodesta
Journal: Metabolism (1995)

It has been shown that in contrast to peripheral fat, visceral fat is an important risk factor for cardiovascular diseases and diabetes. In this study, we investigated whether dexfenfluramine (dF), a compound known to decrease body fat, affects fat mass differentially in various regions of the body. We used a moderately obese rat model fed a high-fat diet (40% fat). After 35 days on the diet, rats were divided into three groups: a dF-treated group ([D]2.5 mg/kg intraperitoneally twice daily), a pair-fed group (Cp), and a control group (C) fed ad libitum. C and Cp rats were injected with saline. After 4 weeks of treatment, body fat, fat cell morphology, and metabolism were determined in subcutaneous (inguinal [ING]) and visceral (retroperitoneal [RET] and mesenteric [MES]) fat tissues. Food intake in D and Cp rats was similar, and was lower than in the C group. In comparison to Cp and C rats, D rats had lower body weight and body fat, smaller ING and RET fat pad weights, and smaller fat cell size in all depots. No significant differences were observed in fat mobilization between groups; however, fat accumulation tended to be lower in D rats. These data suggest that dF has an effect on adipose tissue independent of its effect on food intake. However, this effect seems to occur without regional specificity.
Borrelia burgdorferi-associated lymphocytoma cutis simulating a primary cutaneous large B-cell lymphoma
Authors: Florent Grange, Janine Wechsler, Jean-Claude Guillaume, Jacques Tortel, Marie-Claire Tortel, Bruno Audhuy, Benoit Jaulhac, Lorenzo Cerroni
Journal: Journal of the American Academy of Dermatology (2002)
Less hazardous cigarette debated
Authors: G. H. Miller
Journal: JAMA (1979)

<h3>In Reply.—</h3> Most of the issues raised by Drs Miller and Schumaker have been addressed in separate letters, three of which appeared inThe Journal(240:2005; 2142; 2143, 1978) and one that will appear in<i>Science</i>. We welcome the opportunity to summarize our responses here. Miller and Schumaker state that the assumptions for "critical values" have been criticized by a number of prominent statisticians. They support this statement by reference to a single letter by two statisticians, which Science declined to publish. However, a subsequent letter by these same statisticians is to be published in Science, with a rejoinder that refutes each criticism made. Basically, the rejoinder describes fundamental epidemiologic realities of which the critics may not have been aware. Since the rejoinder is to be published in its entirety, it is not repeated here. In any case, our article inThe Journaluses only one statistic from the
Improving the poor prognosis of oral squamous cell carcinoma
Authors: I L Hutchison
Journal: BMJ (1994)

In Britain, oral squamous cell carcinoma kills at least 1400 people each year; nearly two thirds of patients with this cancer will die of their disease.1 But this gloomy proportion does not convey the full picture. Early disease, where the tumour measures less than 2 cm (T1) and there is no metastatic disease, responds to simple, cheap, non- debilitating treatment and has an expected five year survival of 80%.2 The poor prognosis for oral cancer in Britain reflects the large proportion of patients who have advanced disease by the time they are referred for specialist treatment.3

Oral cancer commonly presents as an indolent ulcer.4 These malignant ulcers fail to heal, distinguishing them from the very common traumatic and aphthous ulcers that heal spontaneously within two weeks. The commonest sites of the disease, the mobile tongue, floor of the mouth, and inside of the cheek, are all readily visible. Most cases occur in people over 50 (and in men more frequently than women).1 Tobacco in all its forms is an important risk factor5; excess alcohol intake6, and chewing of betel quid7 have also been implicated.

The cancer is locally invasive and metastasises …
Bronchoscopy in the preoperative staging of oesophageal cancer below the tracheal bifurcation: a prospective study
Authors: M. Riedel *, H.J. Stein **, L. Mounyam **, R Lembeck *, J.r Siewert **
Journal: European Respiratory Journal (2000)

Oesophageal cancer located above the level of the tracheal bifurcation is frequently complicated by its spread into the airways and by the simultaneous occurrence of malignant bronchial tumours. Although bronchoscopy is an essential procedure in identifying malignant tumoral invasion of the airways and detection of primary airway tumours in patients with suprabifurcal oesophageal cancer, its role in patients with infrabifurcal oesophageal cancer is not clear. This study aimed to assess the value of fibreoptic bronchoscopy in the preoperative staging of oesophageal cancer located below the level of the tracheal bifurcation. In a prospective protocol, bronchoscopic findings were correlated with the results of other staging procedures, operative results and survival in 51 patients with oesophageal cancer located below the level of the tracheal bifurcation. One unsuspected primary bronchial cancer in a patient with squamous cell oesophageal cancer and one case of lower lobe invasion of an oesophageal adenocarcinoma were found. By excluding from surgery these two patients in whom curative resection was not possible bronchoscopy was the sole decisive staging investigation in 6.5% of potentially operable and 3.9% of all patients. Suspect macroscopic abnormalities were shown in 15.7% of the patients at bronchoscopy. Taking bronchoscopic biopsy as the gold standard the positive predictive value for all macroscopic abnormalities was only 25% (95% confidence interval (CI) 3.2-65.1%). The overall accuracy of bronchoscopy with biopsy and brush and washing cytology in proving or excluding airway invasion in otherwise potentially operable patients was 100% (95% CI 89.4-100%). Bronchoscopy is useful in the preoperative staging of oesophageal carcinoma located below the level of the tracheal bifurcation, particularly if the oesophageal cancer is of the squamous cell type.
Disinfectants and plastic mop heads
Authors: J. W. Gibson, M. Loxley, J. Ridge
Journal: BMJ (1967)

he reached 999 years, and that among others the local clergyman might claim the fees he would normally receive for the burial service.Pockrich was a most remarkable rather offbeat character who produced visionary schemes which caused him to be referred to at a recent meeting of the Section of History in the Royal Irish Academy of Medicine in Ireland as a poor man's Leonardo da Vinci.-
Skin disease and the gut.
Authors: E. J. Moynahan
Journal: BMJ (1970)

MEDICBUAAL 559were inserted into the fossa navicularis, approximately 10 mm. from the exterior.It may be significant that the swabs were transported in our mycoplasma transport medium, which contains yeast extract and 20% unheated horse serum,3 and were not frozen.We have frequently isolated H.S.V. from cervical swabs transported in nutrient broth, but it is possible that a higher number of isolations of H.S.V. might be achieved by using a transport medium enriched with serum.-Weare, etc.,
Free Circulating DNA: Good As a Diagnostic Marker in Lung Cancer?
Authors: Ozden Altundag, Kadri Altundag, Muzaffer Altundag
Journal: Journal of Clinical Oncology (2004)

demonstrate a mature survival benefit for an aromatase inhibitor over tamoxifen. 6Aromatase inhibitors are now under evaluation in the adjuvant setting, where a significantly higher proportion of the trial population treated with aromatase inhibitors will remain free of disease, and their true survival benefits over tamoxifen will become evident.
From persistent generalised lymphadenopathy to AIDS: who will progress?
Authors: C A Carne, I V Weller, C Loveday, M W Adler
Journal: BMJ (1987)

Adverse reactions to drugs in childrenMost studies of adverse reactions to drugs in children have observed those who received drugs in hospital or at home shortly before admission.I-3 As the use of drugs in hospital is considerably different from that outside2 45 the incidence and nature of adverse reactions might also be expected to vary.We aimed to discover the incidence and nature of adverse reactions to drugs in a large group ofchildren considered to be representative of the total child population. Subjects, methods, and resultsWe surveyed 1590 children over two periods of 13 weeks in the summer and winterof 1984-5.They were pupilsor siblings of pupils attending 19 infant care or educational establishments around Birmingham. Parents were asked to record on a weekly questionnaire the drugs being taken by their children, both prescribed and non-prescribed, and whether adverse reactions to the drugs had been seen.
Congenital poikiloderma: treatment with etretinate
Authors: D. Shuttleworth, R. Marks
Journal: British Journal of Dermatology (1988)

Journal Article Congenital poikiloderma: treatment with etretinate Get access D. Shuttleworth, D. Shuttleworth Department of Medicine (Dermatology), University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, U.K. Search for other works by this author on: Oxford Academic Google Scholar R. Marks R. Marks Department of Medicine (Dermatology), University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, U.K. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 118, Issue 5, 1 May 1988, Pages 729–730, https://doi.org/10.1111/j.1365-2133.1988.tb02581.x Published: 01 May 1988
Sama Vote in the AMA?
Authors: Everett R. Spencer
Journal: New England Journal of Medicine (1971)

Among the 104 resolutions considered by the House of Delegates of the American Medical Association, meeting in Atlantic City, June 20–24, 1971, was the following, introduced by William Y. Rial, M.D., of Pennsylvania:Whereas, the American Medical Association recognizes the importance of improved communication with medical students; andWhereas, the AMA should have the full benefit of such communication to the House of Delegates through the voices of the delegates from the Student American Medical Association; therefore be it Resolved, that the Constitution and Bylaws of the AMA be revised so that full rights and privileges of delegates be granted . . .
Cancer Therapy: Gold Nanoparticle‐Loaded Neural Stem Cells for Photothermal Ablation of Cancer (Adv. Healthcare Mater. 7/2013)
Authors: Kenna Schnarr, Rachael Mooney, Yiming Weng, Donghong Zhao, Elizabeth Garcia, Brian Armstrong, Alexander J. Annala, Seung U. Kim, Karen S. Aboody, Jacob M. Berlin
Journal: Advanced Healthcare Materials (2013)

Neural stem cells carrying internalized gold nanorods home in on cancer. Stimulating the nanorods with a near infrared laser causes them to heat up and kill surrounding cancer cells. The laser alone is non-harmful so cell killing only occurs where the stem cells have taken the nanorods. Further details can be found in the article by Jacob M. Berlin, Karen S. Aboody, and co-workers on page 976.
The Coronary Arteriogram
Authors: Herbert L. Abrams, Douglass F. Adams
Journal: New England Journal of Medicine (1969)

DURING the last 40 years the number of deaths from coronary disease has increased strikingly, in association with a marked prolongation of the average life-span. Since Herrick's1 original description of the clinical features of acute coronary occlusion in 1912, there has been relatively little progress toward better understanding or more rational management in spite of a virtual crash program of research. To be sure, we can now characterize the "typical" coronary patient: he is "a mesomorphic, obese, middle-aged male with high serum cholesterol, high blood pressure, low vital capacity and an abnormal electrocardiogram. He eats too much of too rich . . .
Comparison of the metabolic effects of recombinant human insulin-like growth factor-I and insulin. Dose-response relationships in healthy young and middle-aged adults.
Authors: S D Boulware, W V Tamborlane, N J Rennert, N Gesundheit, R S Sherwin
Journal: Journal of Clinical Investigation (1994)

The actions of recombinant human insulin-like growth factor-I (rhIGF-I) and insulin were compared in 21 healthy young (24 +/- 1 yr) and 14 healthy middle-aged (48 +/- 2 yr) subjects during 3-h paired euglycemic clamp studies using one of three doses (rhIGF-I 0.2, 0.4, and 0.8 micrograms/kg.min and insulin 0.2, 0.4, and 0.8 mU/kg.min, doses chosen to produce equivalent increases in glucose uptake). In younger subjects, rhIGF-I infusions suppressed insulin by 19-33%, C-peptide by 47-59% and glucagon by 33-47% (all, P < 0.02). The suppression of C-peptide was less pronounced with insulin than with rhIGF-I (P < 0.007). The metabolic responses to rhIGF-I and insulin were remarkably similar: not only did both hormones increase glucose uptake and oxidation in a nearly identical fashion, but they also produced similar suppression of glucose production, free fatty acid levels, and fat oxidation rates. In contrast, rhIGF-I had a more pronounced amino acid-lowering effect than did insulin (P < 0.004). In middle-aged subjects, basal IGF-I levels were 44% lower (P < 0.0001) whereas basal insulin and C-peptide were 20-25% higher than in younger subjects. Age did not alter the response to rhIGF-I. However, insulin-induced stimulation of glucose uptake was blunted in older subjects (P = 0.05). Our data suggest that absolute IGF-I and relative insulin deficiency contribute to adverse metabolic changes seen in middle age.
Efficient nuclear drug translocation and improved drug efficacy mediated by acidity-responsive boronate-linked dextran/cholesterol nanoassembly
Authors: Jing-Yi Zhu, Qi Lei, Bin Yang, Hui-Zhen Jia, Wen-Xiu Qiu, Xuli Wang, Xuan Zeng, Ren-Xi Zhuo, Jun Feng, Xian-Zheng Zhang
Journal: Biomaterials (2015)
Physician Retraining: A Follow-up Report
Authors: Alan S. Kaplan
Journal: JAMA (1972)

<h3>To the Editor.—</h3> In June of 1966, under a contract with the Public Health Service, a pilot project to retrain inactive physicians was instituted at the Pacific Medical Center in San Francisco. The project was completed in October 1968 after 19 physicians had been retrained. This is a follow-up report on those 19 physicians. The project, fully described in<i>California Medicine</i><sup>1</sup>was basically an individually tailored program designed to meet the students' needs from educational as well as career-oriented points of view. The initial group of eight was later followed by another group of 11. While the initial group did receive stipends, the latter group received only a token amount. As this project progressed, its potential for success was recognized and an attempt was made to define the available student body, as well as other possible centers. A study<sup>2</sup>was undertaken by the AMA's Department of Survey Research.
Allergy to cows' milk presenting as chronic constipation.
Authors: K C Chin, M J Tarlow, A J Allfree
Journal: BMJ (1983)

blurred vision, other anticholinergic effects, or headache.Nausea persisted for three days after the overdose but had not been mentioned during treatment.This case provides further evidence of the safety of zimeldine in overdose.[Sales of zimeldine in all countries were discontinued by Astra Pharma- ceuticals in September 1983 because of the company's concern about reports of serious neurological side effects including the Guillain Barre syndrome.]
Ramps and rails.
Authors: A F Travers
Journal: BMJ (1991)

About one in 100 members of the population of the United Kingdom uses a wheelchair' and many more have other disabilities.A quarter of the over 75s are housebound,2 in some cases for lack of a simple means of crossing their-own doorsteps.Others, though able to get out of the house, cannot travel easily or enter other buildings.Ramps empower disabled people by pro- viding access to their homes, other buildings, and vehicles.Rails are the simplest of housing adaptations and can also do much to ease mobility.
Junior doctors accept new pay deal
Authors: H. Morant
Journal: BMJ (2000)

Junior doctors in the United Kingdom have voted overwhelmingly to accept a pay deal that delivers the biggest increases to those working the longest and most antisocial hours. Jobs will fall into one of four bands of pay according to the amount and timing of the additional hours worked. Earnings will no longer be related to the specific number of hours worked.

About half of the 30000 junior doctors responded. Some 79% of the respondents voted to accept the deal negotiated by the BMA's Junior Doctors Committee and the Department of …