tbuckley/cabot-search huggingface dataset:
Optimised function for determining time to peak creatine kinase and creatine kinase-MB as non-invasive reperfusion indicators after thrombolytic therapy in acute myocardial infarction
Authors: H. Schwerdt, C. Ozbek, G. Frohlig, H. Schieffer, L. Bette
Journal: Cardiovascular Research (1990)

The aim of the study was to investigate the use of an optimised function to approximate and interpolate the time course of serum creatine kinase and creatine kinase-MB values after thrombolytic therapy in acute myocardial infarction.A three parameter interpolating function was developed which approximates the time course of serum enzyme levels. In the proposed function, time to peak creatine kinase and maximum of creatine kinase determined from raw data were used as starting parameters of the non-linear interpolation routine, thus providing ideal starting conditions for the iteration. The efficacy of the function was compared with that of three other functions cited in published reports (log-normal distribution function, modified gamma density function, three compartment function).Serum enzyme data from 20 patients with acute myocardial infarction were used in the comparisons. The patients have all been treated with anisoylated plasminogen streptokinase activator complex.In comparison with the other models, deviations of the experimental model function from the raw data were minimal. The fit remained stable for time intervals between blood samples of up to 6 h. CONCLUSIONS - Due to its numerical stability, the function outlined in this study is suitable for large clinical reperfusion trials. In the case of uncomplicated infarctions without thrombolytic therapy, the area under the creatine kinase activity curve could be directly calculated in terms of maximum activity and time to peak.
First NHS walk-in health centres announced for England
Authors: L. Beecham
Journal: BMJ (1999)

By the end of this year there will be 19 NHS walk-in care centres in England, where people will be able to receive advice and treatment without an appointment. Many will be open from early morning to late evening, seven days a week.

Earlier this year, the health secretary, Mr Frank Dobson, announced that £280m ($448m) would be allocated over three years for walk-in centres and for expansion of NHS Direct, a nurse led, 24 hour telephone helpline (24 April, p 1097). The …
Physical Restraint Use in Nursing Homes
Authors: Florian Riese, Christoph Hock
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
European cross border healthcare moves a step closer
Authors: R. Watson
Journal: BMJ (2010)

Patients will enjoy stronger rights for reimbursable medical treatment in another European Union country under proposals approved by the European parliament’s environment and public health committee.

Amendments overwhelmingly endorsed by the committee on 27 October to draft legislation on cross border healthcare would limit the scope for national authorities in the patient’s home country to refuse to pay for the treatment. They would give special rights to people with rare diseases and ensure that anyone contemplating medical care abroad has access to all the relevant information, including the costs involved.

The legislation follows a series of rulings by the European Court of Justice in recent years confirming that the public has a right to refundable treatment in another EU …
Interdependence of Medical and Allied Health Education
Authors: Robert J. Atwell
Journal: JAMA (1970)

My first reaction, when asked to speak about the interdependence of medical and allied health education, was that this would be an easy topic. I could simply say that there is precious little. Probably this would be the most provocative approach to the problem. I have given much thought to the existing patterns of education for these two branches of health, and it is obvious that interrelationship could be greatly improved. But the question of how best to achieve this is not so simple. I don't pretend to understand all of the problems, let alone have the solutions. During the past two days, I have been meeting with the Student American Medical Association where the medical students have been addressing themselves to some of these very same problems. This has been a very interesting experience. Let's begin by looking briefly at existing educational processes in the allied health professions. If
Israel issues guidelines on prolonging life
Authors: J. Siegelitzkovich
Journal: BMJ (1996)

The Israeli health ministry and the Israel Medical Association have joined forces to issue guidelines for hospital staff faced with terminally ill patients who decline medical procedures to prolong their life temporarily.

The detailed recommendations, signed by the ministry's director general, Dr Meir Oren, were sent to all hospitals after a spate of recent court cases, in which patients asked to be allowed to die …
Gordon H D McNaught
Authors: E. McNaught, R. W. Thomson
Journal: BMJ (2012)

Background/Aim: Advanced prostate cancer is a recalcitrant disease with very limited treatment options. Our laboratory discovered methionine addiction, presumably a characteristic of all cancer types, including prostate cancer, which can be targeted by methionine restriction (MR), through treatment with oral recombinant methioninase (o-rMETase). Patients and Methods: o-rMETase was produced by fermentation of recombinant E. coli containing the Pseudomonas putida methioninase gene, and purified by column chromatography. An advanced prostate cancer patient received o-rMETase as a supplement, 500 units per day, divided into two oral doses of 250 units each. Results: Before treatment, the patient had a rapid rise in PSA levels, from 39 to 56 ng/ml, within 6 weeks. At the 15<sup>th</sup> week of o-rMETase administration, the PSA levels stabilized at 62 ng/ml. No overt side effects were observed. Conclusion: o-rMETase single treatment can be beneficial for advanced prostate cancer patients.
DRUG-ELUTING STENTS VERSUS BARE METAL STENTS IN PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION
Authors: Bilal Iqbal, Charles Ilsley, Tito Kabir, Robert Smith, Rebecca Lane, Mark Mason, Abtehale Al-Hussaini, Andrew Archbold, Tom Crake, Sam Firoozi, Sundeep Kalra, Charles Knight, Pitt Lim, Anthony Mathur, Iqbal Malik, Pascal Meier, Roby Rakhit, Simon Redwood, Mark Whitbread, Dan Bromage, Krishna Rathod, Andrew Wragg, Philip MacCarthy, Miles Dalby
Journal: Journal of the American College of Cardiology (2014)
Endoscopic Ultrasound-Assisted Rendezvous Maneuver to Achieve Pancreatic Duct Drainage in Obstructive Chronic Pancreatitis
Authors: U. Will, F. Meyer, T. Manger, I. Wanzar
Journal: Endoscopy (2005)

Patients with mechanical obstruction of the pancreatic duct, which can be caused by chronic pancreatitis, suffer from recurrent attacks of pain and inflammation of the pancreas. We report a novel approach using an endoscopic ultrasound- (EUS-) assisted rendezvous technique, which allows drainage of the pancreatic duct in patients in whom primary management by transpapillary drainage during an endoscopic retrograde cholangiopancreatography (ERCP) procedure has failed. Transgastric puncture of the pancreatic duct was performed using a 19-gauge needle under EUS guidance, and a 0.035-inch guide wire was introduced into the duct and advanced through the papilla. This wire was pulled into the duodenum using a side-viewing duodenoscope. A papillotomy was performed using the standard technique and a plastic prosthesis was introduced. The patient tolerated the intervention well and was discharged with no further complaints. EUS-assisted drainage of the pancreatic duct using a rendezvous technique is an elegant and feasible minimally invasive endoscopic treatment for symptomatic patients with chronic pancreatitis, in whom transpapillary introduction of a catheter is not possible.
GAO Finds Variations in Private Insurer Payments for Costly Procedures
Authors: Rita Rubin
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Disturbances in the tissue plasminogen activator/plasminogen activator inhibitor (TPA/PAI) system in systemic lupus erythematosus
Authors: Guillermo J. Ruiz‐Argüelles, Alejandro Ruiz‐Argüelles, Eduardo Lobato‐Mendizábal, Felipe Díaz‐Gomez, Elda Pacheco‐Pantoja, Cristina Drenkard, Donato Alarcón‐Segovia
Journal: American Journal of Hematology (1991)

Increased thrombogenesis observed in systemic lupus erythematosus (SLE) is derived from multiple mechanisms, including: Enhanced coagulation factor VIII:VWf activity, lupus anticoagulants, anti-phospholipid antibodies, acquired deficiencies of natural anti-thrombotic mechanisms (protein C, protein S, anti-thrombin III), and impaired fibrinolytic mechanisms. We studied the fibrinolytic mechanisms of 18 patients with systemic lupus erythematosus, selected carefully to avoid other possible causes of abnormalities in the fibrinolytic activity. Despite the fact that the euglobulin lysis time in steady state was normal in all instances, disturbances in the tissue plasminogen activator/plasminogen activator inhibitor (TPA/PAI) system were found in all SLE patients: TPA activity was undetectable in all cases, whereas it was above 0.4 IU/ml in a control group. In 72 percent of patients, the undetectable TPA activity was correlated with abnormally high PAI activity; PAI levels were normal in all members of the control group, their mean value being 0.74 versus 8.63 IU/ml for SLE patients (P less than .01). Coagulation protein C deficiency was found in 3 patients (17%). Even though within normal range, fibrinogen levels were significantly higher in SLE than in normal controls (219 versus 192 mg/dl, P less than .01) and plasminogen levels were significantly higher in SLE than in controls (117 versus 78.2%, P less than .01). Cross-linked fibrin derivatives (D-D dimers) were negative in all patients with SLE. Sixty-eight percent of SLE patients had high levels of antiphospholipid antibodies, but no correlation with the disturbances of the TPA/PAI system was found. It is concluded that most patients with SLE display severe abnormalities in the TPA/PAI anti-thrombotic system and that these abnormalities may be related to the lupus thrombophilia, apparently multifactorial in its origin.
The Children's Dermatology Life Quality Index: validation of the cartoon version
Authors: S.A. Holme, I. Man, J.L. Sharpe, P.J. Dykes, M.S. Lewis-Jones, A.Y. Finlay
Journal: British Journal of Dermatology (2003)

Summary Background In 1995 the Children's Dermatology Life Quality Index (CDLQI) was developed as a tool to allow quality of life assessment of children with skin conditions. This initial questionnaire was in a written format. Objectives Using the same validated questions, a full‐colour cartoon version has been developed. The aim of this study was to validate this against the initial written questionnaire in a three‐part study. Methods The first part of the study piloted the use of both versions in an outpatient setting. One hundred and one children completed both versions of the CDLQI in a random order. A further 66 children completed the cartoon CDLQI in outpatients, and subsequently completed the cartoon version on the same day at home, which was returned by post. The scores were compared. In the second part, in more controlled conditions to eliminate parental and investigator bias, 107 children with current dermatological problems were administered both versions of the CDLQI in a random order. The scores were analysed, and time to complete each version, and the child and parental preferences, were recorded. The third part assessed compliance by asking 546 children recently reviewed in dermatology clinics to return a single completed postal CDLQI. Half of the children were given the text, and half the cartoon version. Results The median age of participating children was 11 years. There was no significant difference in scores between the two versions in both parts 1 and 2, but the cartoon version was completed faster (median 90 s) than the written version (median 120 s) (P < 0·0001). Both children and their parents significantly preferred the cartoon version and found it easier to use. Forty‐six per cent of the postal CDLQI questionnaires were returned; there was no difference in compliance between the two versions. Conclusions The cartoon CDLQI is equivalent to the previously validated written CDLQI version, but is faster and easier for children to use, and is preferred by both children and parents.
Points from Letters: Sex of Human Offspring
Authors: W. H. James
Journal: BMJ (1972)

the dose we prescribed facilitate further rehabilitation of the patients.Our experience, however, does confinn the findings of other workers that very large doses of the drug do not produce any parallel increase in iatrogenic Parkinsonian symptoms.We felt reluctant to inject the drug more frequently than once a week.The advantage of a longacting parenteral phenothiazine drug lies in its infrequent administration.Daily injection at the dose suggested by Kline et al. negates any advantage that parenteral therapy may have over oral phenothiazines.-Weare, etc.,
Trial of steroids for treating head injury begins
Authors: Z. Kmietowicz
Journal: BMJ (1999)

<h3>Abstract</h3> <h3>Background</h3> In Ethiopia, the prevalence of exclusive breastfeeding (EBF) is 60.1%, which is lower than the national Health Sector Transformation Plan 2016-2020, National Nutrition Program 2016–2020 and WHO global target. This may be attributed to multidimensional factors. <h3>Objective</h3> The aim of this meta-analysis was to investigate the association between EBF and educational status, household income, marital status, media exposure, and parity in Ethiopia. <h3>Methods</h3> Databases used were PubMed, EMBASE, Web of Science, SCOPUS, CINAHL and WHO Global health library, and key terms were searched using interactive searching syntax. It was also supplemented by manual searching. Observational studies published between September 2000 and March 2019 were included. The methodological quality of studies was examined using the Newcastle-Ottawa Scale (NOS) for cross-sectional studies. Data were extracted using the Joanna Briggs Institute (JBI) data extraction tool. To obtain the pooled odds ratio (OR), extracted data were fitted in a random-effects meta-analysis model. Statistical heterogeneity was quantified using Cochran's Q test, τ<sup>2</sup>, and I<sup>2</sup> statistics. Additional analysis conducted includes Jackknife sensitivity analysis, cumulative meta-analysis, and meta-regression analysis. <h3>Results</h3> Out of 553 studies retrieved, 31 studies fulfilled our inclusion criteria. Almost all studies were conducted on mothers with newborn less than 23 months. Maternal educational status (OR = 1.39; p = 0.03; 95% CI = 1.03 - 1.89; I<sup>2</sup> = 86.11%), household income (OR = 1.27; p = 0.02; 95% CI = 1.05 - 1.55; I<sup>2</sup> = 60.9%) and marital status (OR = 1.39; p = 0.02; 95% CI = 1.05 - 1.83; I<sup>2</sup> = 76.96%) were found to be significantly associated with EBF. We also observed an inverse dose-response relationship of EBF with educational status and income. Significant association was not observed between EBF and parity, media exposure and paternal educational status. <h3>Conclusions</h3> In this meta-analysis, we depicted the relevant effect of maternal education, income, and marital status on EBF. Therefore, multifaceted, effective, and evidence-based efforts are needed to increase national breastfeeding rates in Ethiopia.
Research seems to be gaining upper hand on what's been called non-A, non-B hepatitis
Authors: C. Marwick
Journal: JAMA (1990)

TWO REPORTS on hepatitis virus type C (HCV) in this issue of<i>JAMA</i>, as well as recent articles elsewhere (<i>N Engl J Med</i>. 1989;321:1538-1539, 1494-1500, and 1501-1510), provide strong evidence that the long, frustrating search for the cause of most—if not all— of what has been called non-A, non-B (NANB) hepatitis may be over and that a better blood-screening assay to prevent tranfusion-associated NANB hepatitis may soon be available. This so-called NANB hepatitis has accounted for a substantial proportion of acute and chronic liver disease in the United States. According to Miriam J. Alter, PhD, chief of hepatitis surveillance, Centers for Disease Control (CDC), Atlanta, Ga, approximately 150 000 NANB hepatitis infections occur each year in this country, half of which produce biochemical evidence of chronic liver disease, with approximately 15 000 leading to chronic active hepatitis or cirrhosis. In addition, the virus may be causally associated with hepatocellular carcinoma.
The Effectiveness of Mobile-Health Technology-Based Health Behaviour Change or Disease Management Interventions for Health Care Consumers: A Systematic Review
Authors: Caroline Free, Gemma Phillips, Leandro Galli, Louise Watson, Lambert Felix, Phil Edwards, Vikram Patel, Andy Haines
Journal: PLoS Medicine (2013)

Mobile technologies could be a powerful media for providing individual level support to health care consumers. We conducted a systematic review to assess the effectiveness of mobile technology interventions delivered to health care consumers.We searched for all controlled trials of mobile technology-based health interventions delivered to health care consumers using MEDLINE, EMBASE, PsycINFO, Global Health, Web of Science, Cochrane Library, UK NHS HTA (Jan 1990-Sept 2010). Two authors extracted data on allocation concealment, allocation sequence, blinding, completeness of follow-up, and measures of effect. We calculated effect estimates and used random effects meta-analysis. We identified 75 trials. Fifty-nine trials investigated the use of mobile technologies to improve disease management and 26 trials investigated their use to change health behaviours. Nearly all trials were conducted in high-income countries. Four trials had a low risk of bias. Two trials of disease management had low risk of bias; in one, antiretroviral (ART) adherence, use of text messages reduced high viral load (>400 copies), with a relative risk (RR) of 0.85 (95% CI 0.72-0.99), but no statistically significant benefit on mortality (RR 0.79 [95% CI 0.47-1.32]). In a second, a PDA based intervention increased scores for perceived self care agency in lung transplant patients. Two trials of health behaviour management had low risk of bias. The pooled effect of text messaging smoking cessation support on biochemically verified smoking cessation was (RR 2.16 [95% CI 1.77-2.62]). Interventions for other conditions showed suggestive benefits in some cases, but the results were not consistent. No evidence of publication bias was demonstrated on visual or statistical examination of the funnel plots for either disease management or health behaviours. To address the limitation of the older search, we also reviewed more recent literature.Text messaging interventions increased adherence to ART and smoking cessation and should be considered for inclusion in services. Although there is suggestive evidence of benefit in some other areas, high quality adequately powered trials of optimised interventions are required to evaluate effects on objective outcomes.
Report suggests that NHS is unsustainable in present form
Authors: A. Ferriman
Journal: BMJ (1999)

A new report that questions the sustainability of the NHS in its present form was published last week by the Nuffield Trust and Cambridge University's Judge Institute of Management Studies.

The report, which is the distillation of 10 specially commissioned technical papers, predicts that the NHS will have to levy higher charges on users and increase the rationing of services in future.

Rationing could take two forms: certain treatments may be restricted to certain categories of patients (just as sildenafil is restricted to patients with specified conditions) and whole services may be excluded from …
Migration of Doctors — Dangers of Advertising — Facts about Sickness
Authors: John Lister
Journal: New England Journal of Medicine (1959)

FOR many years the great medical schools of Edinburgh and Glasgow have trained more students than can be absorbed into practice in Scotland, and the Scottish graduate has always been a familiar figure not only in other parts of Great Britain but also in more distant parts of the world. Recently, however, there has been a greater tendency for doctors from all over Britain to seek employment overseas. This tendency to emigrate affects not only the young, unestablished practitioner, because university workers and general practitioners have also been on the move; indeed, in a large sample of established general practitioners . . .