tbuckley/cabot-search huggingface dataset:
Unwitting Heparin Abuse in a Drug Addict
Authors: Zeba Maqbool, H. Heisler Billett
Journal: Annals of Internal Medicine (1982)

Letters and Corrections1 June 1982Unwitting Heparin Abuse in a Drug AddictZEBA MAQBOOL, M.D., H. HEISLER BILLETT, M.D.ZEBA MAQBOOL, M.D.Search for more papers by this author, H. HEISLER BILLETT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-6-790_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: There have been frequent reports on oral anticoagulant abuse. Less common is the surreptitious use of heparin by patients (1, 2). We report here a case of unwitting heparin abuse.A 23-year-old woman was hospitalized because of fever and progressive swelling and tenderness of the right foot after attempts to inject heroin through a pedal vein. She was a thin woman and did not appear acutely ill. Physical examination was normal except she had a temperature of 38.3 °C and her right foot was swollen and erythematous. No ecchymoses were present.Laboratory data included a hemoglobin of...References1. MARTINENGSTROMBARRETT CPO. Surreptitious self-administration of heparin. JAMA. 1970;212:475-6. CrossrefMedlineGoogle Scholar2. SCHAMIERCARABELLODAYBARRY AJHW. Factitious heparin administration. Ann Intern Med. 1981;95:592-3. LinkGoogle Scholar3. GENTON E. Guidelines for heparin therapy. Ann Intern Med. 1974;80: 77-82. LinkGoogle Scholar4. JOHNSONWHITEWOOLFWILLIAMS PYIR. Reptilase time in cirrhosis and hepatocellular carcinoma. Br Med J. 1977;2:869-70. CrossrefMedlineGoogle Scholar5. GREENTHOMSONDYMOCKPOLLER GJIL. Abnormal fibrin polymerization in liver disease. Br J Haematol. 1976;34:427-39. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Queens Hospital Center Affiliation Long Island Jewish-Hillside Medical Center Jamaica, NY 11432 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHIV Infection and Stroke: the Changing Face of a Rising ProblemRefractory hyperkalemia related to heparin abuseLes opioïdesStroke and Substance AbuseOpioidsDrugs 1 June 1982Volume 96, Issue 6_Part_1Page: 790-791KeywordsAnticoagulantsDrug abuseFeversHemoglobinHeparinHeroinInflammationResearch laboratoriesTemperatureVeins Issue Published: 1 June 1982 PDF DownloadLoading ...
Clinical Outcomes According to Baseline Blood Pressure in Patients With a Low Ejection Fraction in the CHARM (Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity) Program
Authors: Peter A. Meredith, Jan Östergren, Inder Anand, Margareta Puu, Scott D. Solomon, Eric L. Michelson, Bertil Olofsson, Christopher B. Granger, Salim Yusuf, Karl Swedberg, Marc A. Pfeffer, John J.V. McMurray
Journal: Journal of the American College of Cardiology (2008)
Consumption of Saturated Fat Impairs the Anti-Inflammatory Properties of High-Density Lipoproteins and Endothelial Function
Authors: Stephen J. Nicholls, Pia Lundman, Jason A. Harmer, Belinda Cutri, Kaye A. Griffiths, Kerry-Anne Rye, Philip J. Barter, David S. Celermajer
Journal: Journal of the American College of Cardiology (2006)
Cardiovascular reflexes mediated by capsaicin sensitive cardiac afferent neurones in the dog
Authors: Janina Staszewska-Woolley, Denise E Luk, Peter N Nolan
Journal: Cardiovascular Research (1986)

Reflex circulatory changes mediated by capsaicin sensitive cardiac afferent neurones were studied in anaesthetised, open chest dogs. Application of capsaicin to the epicardium of the left ventricle, either in single doses (0.01-100 μg) or by supervision (20 μg·min−1), consistently resulted in dose related increases in blood pressure and heart rate. These responses were not affected by bilateral vagotomy but were abolished or reversed by bilateral sectioning of the upper thoracic (T1-T4) white rami communicantes and stellectomy. Injection of capsaicin (0.3-1 μg·kg−1) into the left circumflex coronary artery caused either systemic hypotension and bradycardia (70.3% of experiments), a pressor response associated with tachycardia (13.5%), or a biphasic effect with an initial rise and then fall in blood pressure and heart rate (16.2%). With intravenous injections of capsaicin (3-5 μg·kg−1) the response was invariably cardioinhibitory and depressor. The reflex bradycardia and hypotension evoked with either intracoronary or intravenous injections of capsaicin were reversed after bilateral vagotomy to increases in cardiac rate and blood pressure. The post-vagotomy tachycardia occurring with intracoronary capsaicin could be abolished by beta adrenoceptor blockade with propranolol (0.5 mg·kg−1 iv), whereas ganglionic transmission blockade with pentolinium (0.5 mg·kg−1 iv) eliminated both the tachycardia and pressor effects. The results indicate that in the dog's heart capsaicin sensitive afferent neurones capable of affecting the circulatory system have both vagal and spinal sympathetic origin. It is suggested that capsaicin induced excitatory cardiogenic reflex is nociceptive in nature and may involve activation of substance P containing afferent fibres incorporated in cardiac sympathetic nerves.
Flu vaccine investigator is suspended for four months for research fraud
Authors: C. Dyer
Journal: BMJ (2012)

A researcher on flu vaccines who forged colleagues’ signatures, asked a nurse to sign a false declaration, and recruited himself into a study under a disguised name has been suspended from practice for four months for research fraud.

Iain Stephenson, honorary consultant physician at the University Hospital of Leicester NHS Trust and a clinical senior lecturer at Leicester University, was the principal investigator in one study, an open label study, and a co-investigator in a second, known as the “prime boost study.”

Dr Stephenson’s actions, which also included destroying an original log sheet and replacing it …
SUBCUTANEOUS RUPTURE OF LARGE ARTERIES FROM CONTUSED WOUNDS.
Authors: J. A. CROOK
Journal: JAMA (1899)

In the treatment of this subject I shall not discuss injuries to the arteries as they usually occur, complicated with grave lacerations of the skin and soft parts, but will limit the scope of this paper to those cases where the force of the injury is so directed against the artery as to rupture its walls, while the skin and soft parts remain practically intact. As an introduction to the subject, I present the following case: James W, colored, age 23 years, brakeman, while coupling cars at Grand Junction, Tenn., 1A.M., May 21, 1898, had his right arm caught between the bumpers, the soft parts contused below and above the elbow, the neck of the radius fractured, the vessels ruptured, the skin remaining intact with the exception of slight abrasions of the cuticle in a few places. He was at once attended by a physician, who stated that he
Such stuff as NREM dreams are made on?
Authors: PierCarla Cicogna, Miranda Occhionero
Journal: Behavioral and Brain Sciences (2013)

Abstract The question that we deal with in this commentary is the need to clarify the synergistic role of different non–rapid eye movement (NREM) sleep stages (stages 2 and 3–4) with REM and while awake in elaborative encoding of episodic memory. If the assumption is that there is isomorphism between neuronal and cognitive networks, then more detailed analysis of NREM sleep and dreams is absolutely necessary.
TREATMENT OF FRACTURES OF NECK OF FEMUR
Authors: John J. Moorhead
Journal: JAMA (1931)

<h3>To the Editor:</h3> —Dr. Royal Whitman's comment and criticism of my recent article have been read with much interest and profit. Despite Dr. Whitman's valued opinion, there is no question that<i>any</i>form of treatment of intracapsular fractures of the neck of the femur continues to give most of us unfavorable results. In my article, it was distinctly stated that I had my share of good and poor results by the abduction method. My belief is that this clinical fact is amply substantiated by the figures quoted by Dr. Whitman. The major points I tried to stress were: Inherently this fracture repairs indifferently irrespective of treatment, because of the anatomic structural conditions and the physique of the patients. Plaster-of-paris immobilization often adds to the hazards of the situation. Traction methods applicable to certain joint fractures are equally applicable to certain hip fractures. Dr. Whitman is partisan to complete immobilization for
Danger of Saline Emetics in First-aid for Poisoning
Authors: C. A. K. Bird
Journal: BMJ (1974)

different (t = 163, P = 0 20) and breast and bottle feeding were equally distributed between the two groups x2 = 0 054; N.S.).Though the mean duration of infusion of oxytocin in group 1 (10-8 ± 8-7 hr) was greater than in group 2 (8 0 ± 7-1 hr) the difference was not statistically significant (t = 1 49, P = 0-14).We agree with Dr. B. Alderman and Professor J. M. Beazley (7 September, p. 624) that the first and sixth days are not ideal times to detect peak neonatal bilirubin levels.However, as we pointed out in our paper, the sixth day was a time at which blood was already being taken routinely for amino-acid screening and this timing of samples avoided exposing the infants to additional blood-letting.Though the re- corded peak values in our data may be lower for this reason, any increase in neonatal hyperbilirubinaemia should still be reflected in a higher mean value on the sixth day.-We are, etc.,
Anaphylaxis From Chymopapain-Reply
Authors: I. Leonard Bernstein
Journal: JAMA (1984)

In Reply.—  It is reassuring to learn that commercial postmarketing surveillance of the chemonucleolysis procedure by company officials of Smith Laboratories, up to Aug 29, 1983, did not reveal additional mortality in 18,323 patients. Presumably, the anaphylactic death cited by these respondents occurred some time after August. However, their updated information also indicates that the current incidence (0.7%) of chymopapain-induced significant allergic reactions has not decreased as dramatically as the mortality experience. It would, therefore, be appropriate to assess how many of these significant allergic reactions were near misses with respect to fatal outcome and how therapeutic rescue was accomplished in the potentially lethal cases. Such information would be particularly germane inasmuch as their letter implies that anaphylaxis can be prevented or attenuated by preoperative use of H 1 - and H 2 -receptor blockers, 100% oxygen, and a test dose of 0.2 to 0.3 mL before the therapeutic intradiskal injection.
Travel Medicine to Be Discussed
Authors: Phil Gunby
Journal: JAMA (1990)

AS NATIONS seemingly grow more collegial, opportunities for international travel are growing. So is medical interest in the globe-trotting traveler, and next year a major international conference on the subject will be held in Atlanta, Ga, with the CDC as one of the sponsors. This will be the second Conference on International Travel Medicine. It is scheduled for May 9 through 12, 1991, and cosponsors will include the World Health Organization, a Switzerland-based autonomous unit within the United Nations system with which the CDC works closely; the World Tourism Organization, headquartered in Madrid, Spain; the London School of Hygiene and Tropical Medicine; and Emory University's School of Medicine and Crawford Long Hospital, both in Atlanta. A sampling of topics to be discussed includes jet lag, motion sickness, high-altitude environments, traveler's diarrhea, acquired immunodeficiency syndrome, sexually transmitted diseases, malaria, vector-borne disorders, problems associated with marine life, psychological aspects of travel and
The Bipolar Child: The Definitive and Reassuring Guide to Childhood’s Most Misunderstood Disorder
Authors: Kiki D. Chang, Deval Shah
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Falling through the ICE
Authors: D. Spence
Journal: BMJ (2009)

I don’t like unsolicited advice, and I don’t much believe in the value of lessons or tutors. Advice is mere opinion, and life is about forming our own opinions. Medicine is full of advice, much out of date and the rest impossibly complicated, concealing the fact that it is just plain wrong. But humanity is sustained by being told what to do, so don’t ask intelligent people to actually think—this they are not trained to do. Learning concepts by rote is seen as the concrete foundation …
Number of overweight women in developing countries is increasing
Authors: Roger Dobson
Journal: BMJ (2005)

Most developing countries now have more overweight than underweight women. Numbers of overweight women are increasing at an alarming rate, a new report based on data for women younger than 50 in 36 developing countries has found ( American Journal of Clinical Nutrition 2005;81: 714-21).

In 10 countries, more than half of the women living in urban areas are overweight (body mass index of 25 or more), according to the report. In 18 of the …
Test Your Knowledge: Ten Questions about Dementia
Authors: Gavin Yamey
Journal: PLoS Medicine (2005)

Question 1.What is the median life expectancy after diagnosis of Alzheimer disease?1-2 years 5-6 years 8-9 years 10-11 years Question 2. Roughly what proportion of people in Europe aged over 65 years has some form of dementia?1% 3% 6% 10% 15% Question 3. Which of the following best refl ects the evidence on the effects of estrogen on cognition in postmenopausal women with Alzheimer disease?Randomized, controlled trials found no effects of the drug on Mini Mental State Examination (MMSE)Randomized, controlled trials found an improvement in the MMSE that is sustained for at least one year Randomized, controlled trials found clear evidence of clinical benefi t as measured by clinical rating scales (these assess attributes such as self care, memory, and orientation) Randomized, controlled trials found some short-term improvements in the MMSE, but the effects were small and did not translate into any clinical benefi t Question 4. Which of the following best refl ects the evidence on the side effects in the fi rst year of giving donepezil to patients with Alzheimer disease?In randomized, controlled trials with up to one year of follow-up, donepezil caused severe nausea, vomiting, and diarrhea, and a large proportion of patients withdrew from the drug because of these side effectsThe side effects in randomized, controlled trials were severe and persistent, but only a small proportion of patients withdrew from the drug The side effects in randomized, controlled trials were generally mild and transient, and a systematic review found no difference between donepezil and placebo in the proportion of people who withdrew for any cause
SIGNIFICANT PULMONARY VEIN REMODELING AFTER DUTY-CYCLED BIPOLAR AND UNIPOLAR RADIOFREQUENCY ABLATION FOR SYMPTOMATIC ATRIAL FIBRILLATION
Authors: Marieke Compier, Darryl Leong, Nina Ajmone Marsan, Victoria Delgado, Katja Zeppenfeld, Martin Schalij
Journal: Journal of the American College of Cardiology (2012)
Neurobiology of cytokines. (Methods in Neurosciences, Part A Vol. 16 and Part B Vol. 17)B. De Souza, Academic Press, 1993. Part A £61.00 (xv + 352 pages) ISBN 0 12 185281 4 Part B £58.00 (xiii + 295 pages) ISBN 0 12 185283 0
Authors: L GARCIASEGURA
Journal: Trends in Neurosciences (1994)
Molecular subtype and response to dasatinib, an Src/Abl small molecule kinase inhibitor, in hepatocellular carcinoma cell lines<i>in vitro</i>
Authors: Richard S. Finn, Alexey Aleshin, Judy Dering, Peter Yang, Charles Ginther, Amrita Desai, Danyun Zhao, Erika von Euw, Ronald W. Busuttil, Dennis J. Slamon
Journal: Hepatology (2013)

Hepatocellular carcinoma (HCC) is the fifth most common malignancy and is the third leading cause of cancer death worldwide. Recently, the multitargeted kinase inhibitor sorafenib was shown to be the first systemic agent to improve survival in advanced HCC. Unlike other malignancies such as breast cancer, in which molecular subtypes have been clearly defined (i.e., luminal, HER2 amplified, basal, etc.) and tied to effective molecular therapeutics (hormone blockade and trastuzumab, respectively), in HCC this translational link does not exist. Molecular profiling studies of human HCC have identified unique molecular subtypes of the disease. We hypothesized that a panel of human HCC cell lines would maintain molecular characteristics of the clinical disease and could then be used as a model for novel therapeutics. Twenty human HCC cell lines were collected and RNA was analyzed using the Agilent microarray platform. Profiles from the cell lines in vitro recapitulate previously described subgroups from clinical material. Next, we evaluated whether molecular subgroup would have predictive value for response to the Src/Abl inhibitor dasatinib. The results demonstrate that sensitivity to dasatinib was associated with a progenitor subtype. Dasatinib was effective at inducing cell cycle arrest and apoptosis in "progenitor-like" cell lines but not in resistant lines.These findings suggest that cell line models maintain the molecular background of HCC and that subtype may be important for selecting patients for response to novel therapies. In addition, it highlights a potential role for Src family signaling in this progenitor subtype of HCC.
Unilateral Renal Agenesis and Other Causes of the Solitary Photopenic Renal Fossa
Authors: WILLIAM H. HOWARD, STEPHEN R. BUNKER, ROBERT D. KARL, THOMAS RALSTON, MICHAEL F. HARTSHORNE, MICHAEL A. CAWTHON, JOHN M. BAUMAN
Journal: Clinical Nuclear Medicine (1985)

The differential diagnosis of a solitary photopenic defect in the renal fossa observed at renal scintigraphy is extensive. A case of one of the most unusual causes for this finding, renal agenesis, is presented. Additional cases that illustrate the similarity in the radionuclide appearance of other pathologic entities are also presented. Correlation with clinical findings and other imaging modalities is required to accurately distinguish these conditions.
Value of 131I-"Hippuran" Renography in Urological Investigation
Authors: J. R. Lawrence, A. Doig, I. C. S. Knight
Journal: BMJ (1963)

13'I-" HIPPURAN" RENOGRAPHY BMEIH MmICk JoWU presence of unilateral renal disease or bilateral renal disease predominantly affecting one side.Intravenous pyelograms and 1311-hippuran renograms were assessed in a selected group of 107 patients together with other investigations, including aortograms in 38 cases.Comparison of the pyelogram and renogram findings showed good agreement in 77% of cases.Discrepancies occurred most often in renal artery stenosis; seven cases with unilateral arterial lesions were found, of which six showed abnormalities in the renogram indicating disparity in function between the two kidneys; however, in only three instances did the pyelogram suggest the possibility of this diagnosis.In a few cases a unilateral abnormality in the renogram could not be explained by other methods of investigation.13 1-hippuran renography used in conjunction with intravenous pyelography is of considerable value in the selection of hypertensive patients for aortography and divided renal-function tests.We are indebted to the physicians who referred patients for investigation, and to Dr. R. W. D. Turner for permission to study patients under his care at the Western General Hospital, Edinburgh.We wish to acknowledge the assistance of Dr.
Book Review Alloimmune Disorders of Pregnancy: Anaemia, Thrombocytopenia and Neutropenia in the Fetus and Newborn Edited by Andrew Hadley and Peter Soothill. 282 pp. Cambridge, United Kingdom, Cambridge University Press, 2002. $80. 0-521-78120-5
Authors: Lori J. West
Journal: New England Journal of Medicine (2003)
Desmocollin-specific antibodies in a patient with Hailey-Hailey disease
Authors: D. Ueo, N. Ishii, T. Hamada, K. Teye, T. Hashimoto, Y. Hatano, S. Fujiwara
Journal: British Journal of Dermatology (2015)

Journal Article Desmocollin‐specific antibodies in a patient with Hailey–Hailey disease Get access D. Ueo, D. Ueo Ueo Dermatology Clinic Saiki Oita 876‐0831 Japan Search for other works by this author on: Oxford Academic Google Scholar N. Ishii, N. Ishii Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Kurume Fukuoka 830‐0011 Japan Search for other works by this author on: Oxford Academic Google Scholar T. Hamada, T. Hamada Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Kurume Fukuoka 830‐0011 Japan Search for other works by this author on: Oxford Academic Google Scholar K. Teye, K. Teye Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Kurume Fukuoka 830‐0011 Japan Search for other works by this author on: Oxford Academic Google Scholar T. Hashimoto, T. Hashimoto Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Kurume Fukuoka 830‐0011 Japan Search for other works by this author on: Oxford Academic Google Scholar Y. Hatano, Y. Hatano Department of Dermatology Faculty of Medicine Oita University Hasama Yufu Oita 879‐5593 Japan Search for other works by this author on: Oxford Academic Google Scholar S. Fujiwara S. Fujiwara Department of Dermatology Faculty of Medicine Oita University Hasama Yufu Oita 879‐5593 Japan Correspondence: Sakuhei Fujiwara. E‐mail: fujiwara@oita-u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 173, Issue 1, 1 July 2015, Pages 307–309, https://doi.org/10.1111/bjd.13661 Published: 01 July 2015
Day Care for Children of Hospital Employees
Authors: Jackie Pollock
Journal: JAMA (1983)

<h3>To the Editor.—</h3> Ditto! (1983;249:2090) Capitol Hill Hospital, a 250-bed community hospital, realized the importance of employer-sponsored day care and proudly opened our child care center in October 1982. The center is located within the hospital and serves approximately 36 children from ages 3 months to 4 years. The hospital was able to create a bright and stimulating environment for a minimal start-up cost. Additionally, by establishing a contractual relationship with the Capitol East Children's Center, a local child care center, we have minimized our personnel expenses. Capitol Hill Hospital presently subsidizes more than 50% of the tuition. The result: improved employee morale and more qualified nurses, at a very inexpensive cost. Our biggest problem to date—"When can we expand?"