tbuckley/cabot-search huggingface dataset:
Genes contributing to etoposide-induced cytotoxicity
Authors: Rong S. Huang, Shiwei Duan, Wasim K. Bleibel, Wei Zhang, M. Eileen Dolan
Journal: Clinical Cancer Research (2006)

PR-3   Etoposide is an important chemotherapeutic agent that is used to treat a wide spectrum of human cancers. The degree to which genetic factors contribute to susceptibility to etoposide is not fully understood. We present a comprehensive genetic method that incorporates whole genome association analysis and bioinformatics to uncover genetic variants contributing to susceptibility to etoposide-induced cytotoxicity. EBV-transformed lymphoblastoid cell lines representing 30 trios of European descent and 30 trios of Yoruban descent from the International HapMap consortium were assayed for cell growth inhibition following incubation with increasing concentrations of etoposide for 72 h. Whole genome association with one-way ANOVA test was independently performed on the 60 unrelated CEPH and Yoruban cell lines. Several pathways emerged in each population with the most significant being calcium signaling pathway in both. Two genes within the calcium signaling pathway had single nucleotide polymorphisms (SNPs) significantly associated with etoposide cytotoxicity in both populations; CACNA1C a subunit of a voltage-dependent calcium channel and HDAC9, a histone deacetylase. A total of 5 SNPs and 33 SNPs were significant after additive model linear regression analysis for CACNA1C in the CEPH and Yoruban population; 14 SNPs were significant for HDAC9 in the Yoruban population. This novel method can be used to elucidate variants contributing to chemotherapeutic response.
EU advisory committee members declare their interests
Authors: Rory Watson
Journal: BMJ (2000)

The European Commission has started to implement a new policy of openness by making available to the public any declarations of interest of members of the influential independent committees, which provide the commission with scientific advice.

The move follows a lengthy campaign by the British pressure group Baby Milk Action with support from UK Labour members of the European parliament and was immediately welcomed by the organisation's policy director, Patti Rundall.

“This decision is extremely important, and we warmly welcome it,” she said. She continued: “For consumers to …
Using Collaborative Improvement and Innovation Networks to Tackle Complex Population Health Problems
Authors: Marianne E. McPherson, Peter A. Gloor, Lauren A. Smith
Journal: JAMA Pediatrics (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
MILITARY PSYCHIATRY TODAY
Authors: F J BRACELAND
Journal: Annals of Internal Medicine (1951)

Article1 August 1951MILITARY PSYCHIATRY TODAYFRANCIS J. BRACELAND, M.D., F.A.C.P.FRANCIS J. BRACELAND, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-2-432 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe thing that hath been, it is that which shall be; and that which is done is that which shall be done: and there is no new thing under the sun.Ecclesiastes 1:9.Five years ago, in a report issued at the close of World War II, the present writer stated "Each successive war brings with it new problems, but the old ones crop up repeatedly and as we encounter them again and again we wonder why man is so slow to profit by experience and history. Perhaps the cynic expressed it best of all when he said 'Men learn... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Read at the 32nd Annual Session of the American College of Physicians, St. Louis, Missouri, April 10, 1951. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 August 1951Volume 35, Issue 2Page: 432-436KeywordsArmed forces ePublished: 1 December 2008 Issue Published: 1 August 1951 PDF downloadLoading ...
GMC wins support for revalidation proposals
Authors: Clare Dyer
Journal: BMJ (2000)

The General Medical Council's proposal that doctors should undergo regular revalidation to confirm their fitness to practise has won overwhelming support from both lay and medical consultees, the GMC announced this week.

A report on responses to the consultation exercise, published this week, showed few objections to the idea of revalidation. The report will be debated by the GMC's council next week.

Concerns centred on the way that …
A Revised Quality Measure for Surgical Care
Authors: David R. Urbach, Chaim M. Bell
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arg89Cys Substitution Results in Very Low Membrane Expression of the Duffy Antigen/Receptor for Chemokines in Fyx Individuals
Authors: Christophe Tournamille, Caroline Le Van Kim, Pierre Gane, Pierre Yves Le Pennec, Francis Roubinet, Jérôme Babinet, Jean Pierre Cartron, Yves Colin
Journal: Blood (1998)
231. Supplementation of Peripherin/rds Rescues Mutation-Associated Rod and Cone Photoreceptor Defects in Transgenic Mice
Authors: May Nour, Muna I. Naash, Steven J. Fliesler
Journal: Molecular Therapy (2004)

Top of pageAbstract
Blindness due to genetic abnormalities in photoreceptor-specific proteins represents a significant and largely intractable health problem worldwide. In the present study, we generated transgenic mice carrying point mutations in the photoreceptor-specific protein, peripherin/rds (P/rds), to model human hereditary diseases that involve either rod- or cone-dominant retinal degeneration. We tested the ability of supplemental expression of normal mouse P/rds (NMP) to over-ride the retinal degenerative phenotype and to promote normal visual function in these transgenic lines. Electroretinography, histology at the light and electron microscopy levels, immuno-gold cytochemistry (using anti-rod and -cone opsin antibodies), Western blot analysis, and limited tryptic digestion were used to assess rescue of the retinal disease phenotypes. Herein, we provide the first evidence for P/rds supplementation-mediated rescue of both rod and cone-dominant disease-causing mutations. This efficacious strategy may have broader implications for clinical intervention in P/rds-associated retinal diseases as well as for the treatment of other hereditary blinding disorders.
The lipophilic hapten parthenolide induces IFN-g and IL-13 production by peripheral blood-derived CD8+ T cells from contact allergic subjects in vitro
Authors: Helen Wahlkvist, Khosro Masjedi, Birgitta Gruvberg, Bartek Zuber, Ann-Therese Karlberg, Magnus Bruze, Niklas Ahlborg
Journal: British Journal of Dermatology (2008)

The lipophilic hapten parthenolide induces IFN-g and IL-13 production by peripheral blood-derived CD8+ T cells from contact allergic subjects in vitro
Molecular Defect of Spectrin in Hereditary Pyropoikilocytosis
Authors: Jack Lawler, Shih-Chun Liu, Jiri Palek, Josef Prchal
Journal: Journal of Clinical Investigation (1982)

In hereditary pyropoikilocytosis (HPP) the erythrocyte membrane skeleton exhibits mechanical instability that can be correlated to defective self-association of spectrin heterodimers. To detect structural changes in the functional domains of HPP spectrin we have examined the peptide pattern produced by limited tryptic digestion of spectrin extracts from two families that contain three HPP patients. Limited tryptic digestion of all three HPP patients revealed a similar and reproducible decrease in the staining intensity of an 80,000-, and 22,000-, and an 88,000-dalton polypeptide with a concomitant increase in a 74,000- and a 90,000-dalton polypeptide as compared with controls. Only changes in the 80,000-, and 74,000-, and 22,000-dalton polypeptides could be correlated to defective spectrin self-association and the amount of spectrin dimers in 0 degrees C extracts of the HPP patients and their affected kindred. Similar results were obtained when the tryptic digests were analyzed by two-dimensional isoelectric focusing/sodium dodecyl sulfate-polyacrylamide gel electrophoresis with the affected 74,000- and 80,000-dalton polypeptides focusing into multiple spots ranging in isoelectric point from 5.3-5.4. When HPP spectrin dimers and tetramers were separated and subjected to trypsin digestion, changes in the 80,000-, 74,000-, and 22,000-dalton polypeptides were found predominantly in the spectrin dimer pool. Similar results were obtained for spectrin from two of the probands' mother, whom we have identified as an HPP carrier. We conclude that these HPP patients contain a population of normal, (principally tetrameric) and mutant (principally dimeric) spectrin. The latter is characterized by a defective spectrin dimer self-association due to conformational changes that affect the 80,000-dalton domain.
Postmenopausal Patients with Node-Positive Resectable Breast Cancer
Authors: J.P. Gérard, M. Héry, D. Gedouin, A. Monnier, M.J. Goudier, J.Ph. Jacquin, F. Plat, E. Cabarrot, D. Serin, M. Namer, P. Fumoleau, P. Hurteloup
Journal: Drugs (1993)
NEWER CONCEPTS OF MEDICAL CARE
Authors: R P McCOMBS
Journal: Annals of Internal Medicine (1949)

Article1 July 1949NEWER CONCEPTS OF MEDICAL CAREROBERT P. MCCOMBS, M.D., F.A.C.P.ROBERT P. MCCOMBS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-31-1-125 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPhysicians are confronted with the possibility of drastic changes in methods of medical practice if Congress enacts certain legislation that to some is a measure for health insurance and to others represents an attempt to socialize medicine. Such legislation has been proposed because a sizable segment of the population of this country cannot enjoy the full benefits of medical care of the high caliber available today in only the relatively few teaching centers. The reasons usually given for the maldistribution of medical care are those related to social and economic factors. The cures proposed are likewise chiefly social and economic....Bibliography1. PRATT JH: Better rural medicine, Bull. Am. Med. Assoc., 1932, xxvii, 122-123. Google Scholar2. PROGER SH: The Tufts postgraduate medical program, New England Jr. Med., 1941, ccxxv, 351-358. PROGER, S. H.: Distribution of medical care: a postgraduate program to fit a pattern of medical practice, Jr. Am. Med. Assoc., 1944, cxxiv, 823-826. PROGER, S. H.: Regional organization in Maine. The place of the medical school in the regionalization of hospitals, Modern Hospital, 1944, lxiii, 45-48. PROGER, S. H.: Medical education and medical care, Hospital, 1946, xx, 48-54. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT P. MCCOMBS, M.D., F.A.C.P.Affiliations: Boston, Massachusetts*Received for publication March 13, 1948.From the Department of Medicine, Tufts College Medical School and the New England Center Hospital (Pratt Diagnostic Hospital). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRegulation and the Quality of Medical Care 1 July 1949Volume 31, Issue 1Page: 125-138KeywordsDiagnostic medicineHealth insuranceHospital medicineLegislation ePublished: 1 December 2008 Issue Published: 1 July 1949 PDF downloadLoading ...
The future of specific immunotherapy: strategies and challenges for the next generation of allergy vaccines
Authors: P. Sørensen
Journal: Allergy (2011)

: The use of specific immunotherapy (SIT) for allergic disorders has recently been extended by introduction of a convenient, tablet-based, disease-modifying vaccine against grass pollen allergy. Allergy immunotherapy tablet (AIT) programmes targeting house dust mite and other allergies are currently in late-phase development. Next-generation allergy vaccines can have optimised potency and onset of action without compromising safety or convenience. Key to achieving these objectives is a combination of evidence-based mode-of-action studies and biomarker-centric translational research approaches. This will rely on using biobank and bioinformatics resources for multi-omic characterisations of the 'immunome' of allergic disease. Other important areas are ongoing paediatric trials and long-term studies in adults for further defining the potential role of SIT in allergic disease and primary prevention of asthma. Finally, combining cellular- and serological-based assays, and developments in targeted delivery platforms and component-resolved diagnostics will lead to increased ability to stratify patients, with more personalised diagnosis and treatment.
TREATMENT OF PERIPHERAL VASCULAR DISEASE BY MEANS OF SUCTION AND PRESSURE
Authors: E. M. Landis, L. H. Hitzrot
Journal: Annals of Internal Medicine (1935)

Article1 September 1935TREATMENT OF PERIPHERAL VASCULAR DISEASE BY MEANS OF SUCTION AND PRESSUREE. M. LANDIS, F.A.C.P., L. H. HITZROTE. M. LANDIS, F.A.C.P.Search for more papers by this author, L. H. HITZROTSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-3-264 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAt the meeting of the College in 1934, one of us presented certain observations1indicating that blood flow to the extremities could be increased at least temporarily by applying alternate negative and positive pressure. In patients with peripheral vascular disease and advanced organic arterial occlusion this procedure elevated skin temperature conspicuously, often relieved cyanosis, usually diminished rest pain and favored the healing of indolent ulcers. While symptoms were quite generally relieved it was then felt impossible to do more than speculate upon the permanence of that improvement. To quote the statement then made, "The practical importance of suction and pressure...References1. LANDIS EM: Observations on the diagnosis and treatment of peripheral vascular disease, ANN. INT. MED., 1934, viii, 282-295. Google Scholar2. LANDISGIBBON EMJH: Effects of alternate suction and pressure on circulation in the lower extremities, Proc. Soc. Exper. Biol. and Med., 1933, xxx, 593-595. CrossrefGoogle Scholar3. LANDISGIBBON EMJH: Effects of alternate suction and pressure on blood flow to the lower extremities, Jr. Clin. Invest., 1933, xii, 925-961. CrossrefGoogle Scholar4. LANDISHITZROT EMLH: The clinical value of alternate suction and pressure in the treatment of advanced peripheral vascular disease, Am. Jr. Med. Sci., 1935, clxxix, 305-326. Google Scholar5. LANDISGIBBON EMJH: A simple method of producing vasodilatation in the lower extremities, Arch. Int. Med., 1933, lii, 785-808. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Read at the Philadelphia meeting of the American College of Physicians, May 3, 1935.From the Robinette Foundation, University of Pennsylvania Hospital, and the Metabolic Division of the Philadelphia General Hospital.Aided by grants from the Philadelphia Heart Association and from the Committee on Scientific Research of the American Medical Association. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byKrankheiten der GefäßePeriphere GefäßkrankheitenPeriphere GefäßkrankheitenZur Erkennung und Behandlung peripherer arterieller Durchblutungsstörungen, unter besonderer Berücksichtigung der Arteriographie 1 September 1935Volume 9, Issue 3Page: 264-273KeywordsBlood flowHeartPeripheral vascular diseaseTemperatureUlcers ePublished: 1 December 2008 Issue Published: 1 September 1935 PDF downloadLoading ...
Subendocardial ischemia may explain ST-segment depression during negative stress echocardiograms: a study of endo- and epicardial strain with velocity vector imaging
Authors: Brian Haluska, James L. Hare, David J. Holland, Barakath B. Kareem, Thomas H. Marwick, Tony Stanton
Journal: Circulation (2008)

PurposeST depression (STD) is common during dobutamine stress echocardiography (DSE) and poorly predictive of coronary disease (CAD). We hypothesized that STD may be related to subendocardial ischaemia in individuals without inducible regional wall motion abnormalities (RWMA). We investigated this hypothesis using velocity vector imaging (VVI) to measure myocardial tissue deformation as an index of subendocardial ischemia.Methods Of a total study group of 50 patients without inducible RWMA (age 65 ± 12 years, 54% male), we studied 25 consecutive patients with a minimum of 1mm STD during DSE and compared them to 25 randomly selected controls without ST-depression. Mean Bethesda scores indicated a low 10-year risk of CAD (men 5.0±2.6%, women 6.1±3.0%). Longitudinal endocardial and epicardial peak strain (PS) and peak end-systolic strain (PESS) were measured (blinded) from 3 apical views using VVI. A total of 12 basal and mid-cavity segments at rest and peak stress were measured and averaged. 20 randomly selected patients were used to assess the inter-observer variability of the technique.ResultsThere were no significant differences between groups in terms of baseline demographics, LV volumes, LV mass, EF, resting heart rate (HR) and peak systolic BP (SBP). The STD group had significantly higher resting SBP and lower peak HR. At rest, there were no significant differences in endocardial or epicardial PS or PESS. Intra-observer variability was low (mean ICC 0.55). At peak stress, the STD group had significantly lower endocardial PS (–16.8 ± 2.6% vs –14.6 ± 3.5%, p<0.05) and PESS (p<0.05, see table) than the normal response group. There was no significant difference between groups in epicardial PS (p=NS) and PESS (p=NS, see table).ConclusionST-segment depression during DSE is associated with a significant reduction in endocardial but not epicardial strain when compared to those without ST segment change. This may reflect the influence of subendocardial ischemia.
Neural correlates of self-induced dysphoria
Authors: J V Pardo, P J Pardo, M E Raichle
Journal: American Journal of Psychiatry (1993)

The authors explored the question of whether acute, transient changes in mood are reflected in activation of discrete neuronal systems in the human brain.Using positron emission tomography, they measured the regional cerebral blood flow (CBF) of seven psychiatrically healthy subjects under two conditions. During the control condition the subjects were resting with their eyes closed. During the active condition, with their eyes still closed, they were asked to imagine or recall a situation that would make them feel very sad. They were explicitly asked to experience sadness and to avoid any feelings of anger or anxiety.There were significant differences in regional CBF measured during the control condition and during the active condition, particularly in the inferior and orbitofrontal cortices. Women showed bilateral inferior and orbitofrontal activation, but men displayed predominantly left-sided activation in these areas.The authors conclude that the inferior and orbitofrontal cortices play an important role in normal emotional cognitive processes.
Abstract 18285: Discordant Impact of Baroreflex Activation on Cardiac Output Between the Normal Heart and Failing Heart
Authors: Takafumi Sakamoto, Takamori Kakino, Keita Saku, Kazuo Sakamoto, Kazuya Hosokawa, Kenji Sunagawa
Journal: Circulation (2014)

Introduction:  Baroreflex stabilizes arterial pressure (AP) through modulating sympathetic nervous activity (SNA). We previously reported that arterial changes in resistance and stressed blood volume predominantly contribute to the baroreflex control of AP (AHA 2013). It has been well established that cardiac output (CO) of the normal heart increases greatly with increases in preload, while hardly decreases with increases in afterload. The CO dependence of preload and afterload are opposite in the failing heart. Therefore it is conceivable that the impact of baroreflex activation on CO is discordant between the normal heart and failing heart.   Hypothesis:  We hypothesized that baroreflex activation increases CO in the normal heart, while decreases CO in the failing heart.   Methods:  We used 5 normal and 5 pacing induced heart failure dogs (ejection fraction of 20-30%). Under general anesthesia, we isolated both carotid sinuses and connected them to a servo-controlled piston pump to control intra-sinus pressure (CSP). We set CSP at 80mmHg to allow hemodynamics to reach steadystate. We then increased CSP to 160 mmHg to activate baroreflex and suppress SNA in both group. We measured right atrial pressure (RAP), left atrial pressure (LAP), mean AP and CO.   Results:  In the normal heart, activation of baroreflex did not change LAP (5 ± 1 mmHg vs. 4 ± 1 mmHg, p=ns) or RAP (3 ± 1 mmHg vs. 3 ± 1 mmHg, p=ns) but markedly decreased AP (166 ± 21 mmHg vs. 89 ± 20 mmHg, p   Conclusions:  Activation of baroreflex strikingly reduces LAP and increases CO in dogs with failing heart. The beneficial impacts result from the preload insensitivity and afterload sensitivity of CO in the failing heart. This mechanism may serve as a novel therapeutic strategy for decompensated heart failure.