THE USE OF DICUMAROL AS AN ANTICOAGULANT: EXPERIENCE IN 2,307 CASES
Authors: E V ALLEN, E A HINES
Journal: Annals of Internal Medicine (1947)

Article1 September 1947THE USE OF DICUMAROL AS AN ANTICOAGULANT: EXPERIENCE IN 2,307 CASESEDGAR V. ALLEN, M.D., F.A.C.P., EDGAR A. HINES JR., M.D., F.A.C.P., WALTER F. KVALE, M.D., F.A.C.P., NELSON W. BARKER, M.D., F.A.C.P.EDGAR V. ALLEN, M.D., F.A.C.P., EDGAR A. HINES JR., M.D., F.A.C.P., WALTER F. KVALE, M.D., F.A.C.P., NELSON W. BARKER, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-3-371 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSix years have elapsed since the first report on the clinical use of dicumarol.1 Since that time there have been a number of clinical reports by ourselves and others. The literature has been reviewed previously.2, 3 It is the purpose of this presentation to consider this new therapeutic tool in the light of six years' experience.Dicumarol is a pure chemical compound which may be recovered from spoiled sweet clover and which has been prepared synthetically. The discovery that it is the agent which causes spoiled sweet clover disease of animals which is characterized by hemorrhage, the determination of its...Bibliography1. BUTTALLENBOLLMAN HREVJL: A preparation from spoiled sweet clover [3,3′-methylene-bis-(4-hydroxycoumarin)] which prolongs coagulation and prothrombin time of the blood: preliminary report of experimental and clinical studies, Proc. Staff Meet., Mayo Clin., 1941, xvi, 388-395. Google Scholar2. ALLEN EV: The clinical use of anticoagulants. Report of treatment with dicumarol in 1,686 postoperative cases, Jr. Am. Med. Assoc., 1947, cxxxiv, 323-329. CrossrefGoogle Scholar3. 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Staff Meet., Mayo Clin., 1941, xvi, 33-37. Google Scholar8. NICHOLPAGE ESSW: Dicumarol therapy in acute coronary thrombosis; results in fifty attacks, with review of data on embolic complications and immediate mortality in myocardial infarction, Jr. Florida Med. Assoc., 1946, xxxii, 365-370. Google Scholar9. PETERSGUYTHERBRAMBEL HRJRCE: Dicumarol in acute coronary thrombosis, Jr. Am. Med. Assoc., 1946, cxxx, 398-403. CrossrefGoogle Scholar10. WRIGHT IS: Experiences with dicumarol (3,3′methylene-bis-[4-hydroxycoumarin]), in the treatment of coronary thrombosis with myocardial infarction; preliminary report, Am. Heart Jr., 1946, xxxii, 20-31. CrossrefGoogle Scholar11. PARKERBARKER RLNW: The treatment of acute myocardial infarction with anticoagulants, Proc. Staff Meet., Mayo Clin., 1947, xxii, 185-192. Google Scholar12. NAYBARNES RMAR: Incidence of embolic or thrombotic processes during immediate convalescence from acute myocardial infarction, Am. Heart Jr., 1945, xxx, 65-76. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minnesota*Read at the Twenty-Eighth Annual Session of the American College of Physicians Chicago, Illinois, May 1, 1947.From the Division of Medicine, Mayo Clinic. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHeparin and a VKA — a winning combinationAntithrombotic prophylaxis in major orthopaedic surgery: an historical overview and update of current recommendationsPulmonary Embolism: What Have We Learned Since Virchow?Guideline-based Consultation To Prevent Anticoagulant-related Bleeding A Randomized, Controlled Trial in a Teaching HospitalC. Seth Landefeld, Philip A. Anderson, MDAcute and chronic pulmonary thromboembolism: current perspectives part viii: summaRy and referencesAnticoagulants and the elderly: A researh dilemmaValue of Anticoagulants in the Treatment of Pulmonary Embolism: A Discussion Paper 1Milestones in the use of interruption in venous thromboembolismHemarthrosis associated with sodium warfarin therapyPrevention of venous thromboembolismNatural history of pulmonary embolismPulmonary embolism and disseminated intravascular coagulationIntramural hematoma of the duodenumBleeding during oral anticoagulant therapyTreatment of Pulmonary Embolic DiseasePulmonary EmbolismAngiography in Pulmonary EmbolismIndications for Anticoagulant TherapyTreatment of Deep-vein ThrombosisPharmacological Considerations of Antithrombotic TherapyA Twenty-Year Survey of Thromboembolism at the Massachusetts General Hospital, 1939–1959Coumarin Anticoagulant Therapy of Patients with T-Tube Drainage of the Common Bile DuctFibrinolytic Therapy in Acute Deep ThrombophlebitisORAL AND INTRAVENOUS ESTROGENS IN THE TREATMENT AND PREVENTION OF BLEEDING ASSOCIATED WITH LONG-TERM ANTICOAGULANT THERAPYPOSTOPERATIVE PROPHYLACTIC ANTICOAGULANTSANTICOAGULANT DRUGS IN THE TREATMENT OF PULMONARY EMBOLISMUse of anticoagulant and fibrinolytic agentsFibrinolysin (Plasmin) Therapy in Acute Deep ThrombophlebitisKrankheiten der GefäßeUrticaria after administration of warfarin sodiumTheory and Practice in Acute Venous ThrombosisDeep Venous Thrombosis: A Single DiseaseTHE SIGNIFICANCE OF HAEMORRHAGE DURING THE TREATMENT OF PATIENTS WITH THE COUMARIN ANTICOAGULANTSTHE FAILURE OF ANTICOAGULANT THERAPY TO PREVENT MYOCARDIAL INFARCTION IN PATIENTS WITH PREMONITORY SYMPTOMS OF AN IMPENDING CORONARY OCCLUSION*MILTON SCHLACHMAN, M.D., F.A.C.P.THE CONTROL OF EXCESSIVE EFFECT BY ANTICOAGULANTS*†IVAN F. DUFF, M.D., JOHN R. GAMBLE, M.D., PARK W. WILLIS III, M.D., PAUL E. HODGSON, M.D., WILLIAM S. WILSON, M.D., JOSIAH A. POLHEMUS, M.D.Anticoagulant Therapy with Dicumarol Maintained during Major SurgeryVenous thrombosisLong Term Dicumarol Therapy in Thromboembolic Conditions, Especially Coronary Thrombosis.1CONTROL OF ANTICOAGULANT THERAPYTHE PREVENTION OF IMPENDING CARDIAC INFARCTION BY ANTICOAGULANT TREATMENTAnticoagulant Therapy in Peripheral Vascular DiseaseGross Hematuria Due to Dicumarol TherapyDie Behandlung der Thrombose mit gerinnungshemmenden MittelnThe Relationship between Prothrombin Time and Bleeding in the Clinical Use of Dicumarol after OperationTreatment of thrombophlebitisPulmonary EmbolismThromboembolismHypothyroidism Produced by Radioactive Iodine (I 131 ) in the Treatment of Euthyroid Patients with Angina Pectoris and Congestive Heart FailureAcute Venous Thrombosis and EmbolismProblems and Practices in a Community HospitalThrombophlebitisAnticoagulantsPeripheral Arterial EmbolismTOXICITY OF DICUMAROL: REVIEW OF THE LITERATURE AND REPORT OF TWO CASES*JOHN S. POWERS JR.Dicumarol in the treatment of antenatal thrombo-embolic diseaseDicumarol Therapy in Congestive Heart FailureA BOOK REVIEWANTICOAGULANT THERAPYParliamentAnticoagulant Therapy 1 September 1947Volume 27, Issue 3Page: 371-381KeywordsAnticoagulantsHemorrhage ePublished: 1 December 2008 Issue Published: 1 September 1947 PDF downloadLoading ...