MYELOID HYPERPLASIA AND METAPLASIA INDUCED BY EXTRACTS OF URINE FROM PATIENTS WITH MYELOGENOUS LEUKEMIA
Authors: Robert W. Heinle, Joseph T. Wearn, David R. Weir, Frederick A. Rose
Journal: Annals of Internal Medicine (1942)

Article1 December 1942MYELOID HYPERPLASIA AND METAPLASIA INDUCED BY EXTRACTS OF URINE FROM PATIENTS WITH MYELOGENOUS LEUKEMIAROBERT W. HEINLE, JOSEPH T. WEARN, F.A.C.P., DAVID R. WEIR, FREDERICK A. ROSEROBERT W. HEINLESearch for more papers by this author, JOSEPH T. WEARN, F.A.C.P.Search for more papers by this author, DAVID R. WEIRSearch for more papers by this author, FREDERICK A. ROSESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-6-902 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn previous brief reports,1, 2 the effect in guinea pigs of injection of extracts of urine from patients with leukemia has been described. The results indicated that extracts of urine from patients with chronic myeloid leukemia produced myeloid hyperplasia and metaplasia in the organs of guinea pigs with considerably greater frequency than did extracts of urine from patients with other diseases and from normal people.Four different methods of extraction were effective in recovering the active material from the urine of patients with chronic myeloid leukemia. These included the original kaolin adsorption, a benzoic acid adsorption, and a chloroform extraction....Bibliography1. WEARNMILLERHEINLE JTFRRW: Proliferation of the reticulo-endothelial system induced by extracts of urine from patients with leukemia, Trans. Assoc. Am. Phys., 1939, liv, 278. Google Scholar2. MILLERWEARNHEINLE FRJTRW: Proliferation of myeloid and lymphoid cells induced by extracts of urine from leucemie patients, Proc. Soc. Exper. Biol. and Med., 1939, xli, 479. CrossrefGoogle Scholar3. HOUSSAYBIASOTTI BAA: Hypophyse et diabète pancréatique chez les batraciens et les reptiles, Compt.-rend. Soc. de biol., 1933, cxxxiii, 469. Google Scholar4. KATZMANDOISY PAEA: Preparation of extracts of the anterior pituitary-like substance of urine of pregnancy, Jr. Biol. Chem., 1932, xcviii, 739. CrossrefGoogle Scholar5. MILLERHAUSE FRWA: Specific substances in the urine of leukemia patients, Proc. Soc. Exper. Biol. and Med., 1940, xlv, 387. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland, Ohio*Read at the St. Paul meeting of the American College of Physicians April 20, 1942.From the Department of Medicine of Lakeside Hospital and Western Reserve University.The work reported in this paper was made possible by grant from the Commonwealth Fund.†Williams Memorial Fellow in Medicine, financed by a grant from the Edward Mason Williams Fund. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCONJUGATED FORMS OF MYELOKENTRIC AND LYMPHOKENTRIC ACIDSHÆMOPOIETIC STIMULATORS AND LEUKÆMIAThe Leukemias 1 December 1942Volume 17, Issue 6Page: 902-919KeywordsChronic myeloid leukemiaGuinea pigsHospital medicineUrine ePublished: 1 December 2008 Issue Published: 1 December 1942 PDF downloadLoading ...