THE DEVELOPMENT OF BASOPHILIC INCLUSION BODIES IN MYELOMA CELLS AFTER STILBAMIDINE TREATMENT
Authors: I SNAPPER, B SCHNEID
Journal: Annals of Internal Medicine (1947)

Article1 October 1947THE DEVELOPMENT OF BASOPHILIC INCLUSION BODIES IN MYELOMA CELLS AFTER STILBAMIDINE TREATMENTI. SNAPPER, M.D., B. SCHNEID, M.D.I. SNAPPER, M.D.Search for more papers by this author, B. SCHNEID, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-4-541 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been reported previously that in many cases of multiple myeloma injections of stilbamidine—occasionally of pentamidine—exert a favorable influence upon the excruciating pains from which the patients so frequently suffer.1, 2, 3, 4From the beginning it has been emphasized that the disease is not cured by stilbamidine. Even in patients who are markedly relieved, the characteristic myeloma cells still abound in the bone marrow, and Bence Jones proteinuria and hyperglobulinemia continue unabated. At the very best the disease may be halted temporarily. In some patients the relief of pains has persisted for many months. In many cases the...Bibliography1. SNAPPER I: Influence of stilbamidine on multiple myeloma, Jr. Mt. Sinai Hosp., 1946, xiii, 119-127. Google Scholar2. SNAPPER I: Influence of stilbamidine and pentamidine on the course of multiple myeloma, Jr. Am. Med. Assoc., 1947, cxxxiii, 157-161. CrossrefGoogle Scholar3. BAUERJACOBSON WB: Cases from the Medical Grand Rounds of the Massachusetts General Hospital, Am. Pract., 1947, i, 379. Google Scholar4. REICHBRODSKY CA: Coexisting multiple myeloma and Paget's disease of bone treated with stilbamidine, Jr. Bone and Joint Surg. (in press). Google Scholar5. SNAPPERSCHNEID IB: The influence of stilbamidine on myeloma cells, Blood, 1946, i, 534-536. CrossrefGoogle Scholar6. SNAPPERMIRSKYRISSCHNEIDROSENTHAL IAHBM: Development of inclusion bodies containing ribosenucleic acid in myeloma cells after injections of stilbamidine. Determination of stilbamidine in myeloma tissue, Blood (in press). Google Scholar7. SNAPPER I: Unpublished results. Google Scholar8. KOPAC M: Cellular mechanisms in chemotherapy, Trans. New York Acad. Sci., 1945, viii, 5-10. KOPAC, M.: Dissociation of protamine nucleates by aromatic diamidines, Cancer Res. (Proc.), 1946, vi, 491. CrossrefGoogle Scholar9. DAVIDSON JN: Nucleoproteins in growth and development, Edinb. Med. Jr., 1945, lii, 344-356. Google Scholar10. BJORNEBOEGORMSEN MH: Experimental studies on the rôle of plasma cells as antibody producers, Acta path. Scand., 1943, xx, 649. THORELL, B., and WISING, P.: Om äggvitebildningen i myelomcellen, Nordisk Medicin, 1944, xxiv, 1842-1846. BING, J., FAGRAEUS, A., and THORELL, B.: Studies on nucleic acid metabolism in plasma cells, Acta physiol. Scand., 1945, x, 282-294. Google Scholar11. DEMPSEYWISLOCKI EWGB: Histochemical contributions to physiology, Physiol. Rev., 1946, xxvi, 1-27. CrossrefGoogle Scholar12. SNAPPER I: Chinese Lessons to Western Medicine, 1941, Interscience Publishers, Inc., New York, p. 106. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Presented at the Twenty-Eighth Annual Session, The American College of Physicians, Chicago, May 1, 1947.From the Second Medical Service of the Mount Sinai Hospital, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byStudies on the structure—activity relationship among aliphatic and aromatic bisguanylhydrazones and some related compoundsChemotherapy of Neoplastic Disease 1 October 1947Volume 27, Issue 4Page: 541-547KeywordsBone marrowCellsHyperglobulinemiaMedical servicesMultiple myelomaMyelomaProteinuria ePublished: 1 December 2008 Issue Published: 1 October 1947 PDF downloadLoading ...