OBSERVATIONS ON THE RESULTS OF SUBTOTAL ADRENALECTOMY IN THE TREATMENT OF SEVERE, OTHERWISE INTRACTABLE HYPERTENSION AND THEIR BEARING ON THE MECHANISM BY WHICH HYPERTENSION IS MAINTAINED
Authors: C C WOLFERTH, W A JEFFERS, F D W LUKENS, H A ZINTEL, J H HAFKENSCHIEL
Journal: Annals of Internal Medicine (1951)

Article1 July 1951OBSERVATIONS ON THE RESULTS OF SUBTOTAL ADRENALECTOMY IN THE TREATMENT OF SEVERE, OTHERWISE INTRACTABLE HYPERTENSION AND THEIR BEARING ON THE MECHANISM BY WHICH HYPERTENSION IS MAINTAINEDCHARLES C. WOLFERTH, M.D., F.A.C.P., WILLIAM A. JEFFERS, M.D., F.A.C.P., FRANCIS D. W. LUKENS, M.D., HAROLD A. ZINTEL, M.D., D.SC.(Med.), JOSEPH H. HAFKENSCHIEL, M.D.CHARLES C. WOLFERTH, M.D., F.A.C.P.Search for more papers by this author, WILLIAM A. JEFFERS, M.D., F.A.C.P.Search for more papers by this author, FRANCIS D. W. LUKENS, M.D.Search for more papers by this author, HAROLD A. ZINTEL, M.D., D.SC.(Med.)Search for more papers by this author, JOSEPH H. HAFKENSCHIEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-1-8 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe desirability of more effective measures for the treatment of patients with severe arterial hypertension than those now available is conceded by most students of this subject. Although hypertension has been produced in experimental animals in various ways and attempts have been made to lower the levels of arterial pressure produced in these ways, such efforts as yet have neither elucidated the etiology or pathogenesis of essential hypertension, nor have they thus far led to treatment satisfactory to most observers. Nevertheless valuable leads for study of the problem have resulted. Recently much interest has developed in the possible relationships of...Bibliography1. 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DeCourcy JL: Hypertension treated by subtotal bilateral adrenalectomy, J. Internat. Coll. Surg. 13: 619-622, 1950. MedlineGoogle Scholar9. Etienne-Martin P: Rate of adrenal cortex in permanent arterial hypertension, Presse méd. 58: 273-275, 1950. Google Scholar10. GreenNelsonDodds DMJNGA: Effects of adrenal resection on hypertension and diabetes, Fed. Proc. 8: 60-61, 1949. Google Scholar11. GreenNelsonDoddsSmalley DMJNGARE: Bilateral adrenalectomy in malignant hypertension and diabetes, J. A. M. A. 144: 439-443, 1950. CrossrefMedlineGoogle Scholar12. HafkenschielJeffersLukensZintelKefferWolferth JHWAFDHANJCC: Subtotal adrenalectomy in essential hypertension: postural blood pressure responses in relation to type of cortical replacement therapy, Am. J. Physiol. 163: 719, 1950. Google Scholar13. LukensWolferthJeffersZintelHafkenschiel FDCCWAHAJH: Observations on subtotal adrenalectomy in hypertension, Tr. Am. Clin, and Climatol. A., 1950 (in press). MedlineGoogle Scholar14. ZintelWolferthJeffersHafkenschielLukens HACCWAJHFD: Ninety-five per cent subtotal adrenalectomy for essential hypertension, Am. College Surg. "Surgical Forum," 1950, W. B. Saunders Co., Philadelphia. Google Scholar15. ClarkCrosleyBarker JKAPHG: To be published. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Presented in abstract, Thirty-Second Annual Session of the American College of Physicians, St. Louis, Mo., April 9, 1951.This investigation is being supported, in part, by research grants from the National Heart Institute, U. S. Public Health Service, Irwin, Neisler and Company, the Squibb Institute for Medical Research, Sandoz Pharmaceuticals and Eli Lilly and Co.From the Edward B. Robinette Foundation, Cardiac and Hypertension Sections, Medical Clinic, Hospital of the University of Pennsylvania, the Cox Institute and the Department of Surgery, School of Medicine, University of Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byResults of sympathectomy and adrenalectomyBehandlung der benignen und malignen HypertonieTransmembrane gationic gradient and blood pressure regulationRenin und Hypertensin, physiologische oder pathologische Wirkstoffe?The pituitary and adrenal glands of elderly mental hospital patients with and without hypertensionObservations of human adrenal cortical deficiencyDie AdrenalektomieThe Medical Treatment of Essential HypertensionManagement of Adrenocortical InsufficiencyFURTHER OBSERVATIONS ON PATIENTS WITH SEVERE HYPERTENSION SUBJECTED TO ADRENAL RESECTION AND SYMPATHECTOMY*WILLIAM A. JEFFERS, F.A.C.P., HAROLD A. ZINTEL, F.A.C.S., A. GORMAN HILLS, JOSEPH H. HAFKENSCHIEL, STEPHEN B. LANGFELD, ALFRED M. SELLERS, CHARLES C. WOLFERTH, F.A.C.P.Quantitative evaluation of primary adrenal cortical deficiency in manTHE CLINICAL COURSE, FOLLOWING ADRENAL RESECTION AND SYMPATHECTOMY, OF 82 PATIENTS WITH SEVERE HYPERTENSION*WILLIAM A. JEFFERS, F.A.C.P., HAROLD A. ZINTEL, JOSEPH H. HAFKENSCHIEL, A. GORMAN HILLS, ALFRED M. SELLERS, CHARLES C. WOLFERTH, F.A.C.P.EXPERIMENTAL HYPERTENSION*D. M. GREEN, M.D., F.A.C.P.The Management of Essential HypertensionDie koordinierte Rolle von Nerven, Hormonen und Elektrolyten in der Pathophysiologie des BlutdruckesPharmacologic Aspects of Adrenocortical Steroids and ACTH in ManTHE RÔLE OF THE ADRENAL IN HYPERTENSION*JOHN P. MERRILL, M.D.CLINICAL STUDIES ON BILATERAL COMPLETE ADRENALECTOMY IN PATIENTS WITH SEVERE HYPERTENSIVE VASCULAR DISEASE*GEORGE W. THORN, F.A.C.P., J. HARTWELL HARRISON, JOHN P. MERRILL, MODESTINO G. CRISCITIELLO, THOMAS F. FRAWLEY, JOHN T. FINKENSTAEDTWHAT IS THE MODE OF ACTION OF THIOCYANATE COMPOUNDS IN ESSENTIAL HYPERTENSION?*CAROLINE BEDELL THOMAS, M.D., F.A.C.P.Adrenocortical Function in Pernicious Anemia 1 July 1951Volume 35, Issue 1Page: 8-18KeywordsAdrenalectomyBlood pressureCardiac surgeryHospital medicineHypertensionMedical servicesPathogenesisPatientsResearch grantsThoracic surgery ePublished: 1 December 2008 Issue Published: 1 July 1951 PDF downloadLoading ...