tbuckley/cabot-search huggingface dataset:
Abstract 2794: CD8+ natural regulatory T cells as antitumor immune effectors in carcinomas of breast and lung
Authors: Anandi Sawant, Carnella Lee, Cara Schafer, Jessy Deshane, Selvarangan Ponnazhagan
Journal: Cancer Research (2014)

Abstract CD8+ T cells are cytolytic effectors of adaptive immunity against invading pathogens, and under various pathological conditions including cancer. In syngeneic, immunocompetent murine models of epithelial cancers, including breast and lung cancer, we observed up-regulation in frequencies of a unique CD8+ T cell population, characterized as CD8+CD25-Foxp3+, referred here as CD8+ natural regulatory T cells. This regulatory cell population was present in very high numbers during initial stages of tumor growth. However, a drastic reduction in CD8+ natural regulatory T cells was observed as tumor burden increased, and also with the onset of metastasis to distant sites, including bone in the case of breast cancer. Upon further investigation of these cells, we observed that they are highly cytotoxic towards the cancer cells. Adoptive transfer of these CD8+ natural regulatory cells obtained from mice with minimal tumor burden resulted in significantly reduced tumor growth in the tumor-bearing recipients. There was also an inverse relationship between CD8+ natural regulatory T cells and plasmacytoid dendritic cells (pDC) as tumor burden increased. Additionally, depletion of pDC, either using depletion antibody or by using a transgenic mouse model lacking pDC, showed increased numbers of CD8+ natural regulatory T cells that resulted in decreased tumor burden. Analysis of a possible molecular mechanism on the role of CD8+ natural regulatory T cells as anti-tumor effectors demonstrated that these cells express PD-1. Furthermore, PD-L1, a ligand for PD-1, is expressed by both pDC and cancer cells in vivo. Ongoing experiments are focused on deciphering a possible role of PD-1 and PD-L1 interaction in determining the fate of CD8+ natural regulatory T cells in the presence of pDC and cancer cells through in vitro assays and using transgenic murine models and depletion antibodies for both PD-1 and PD-L1. Collectively, these data suggest a novel anti-tumor immune population that has a potential to be used as immunotherapy for cancer in conjunction with conventional treatments. Citation Format: Anandi Sawant, Carnella Lee, Cara Schafer, Jessy Deshane, Selvarangan Ponnazhagan. CD8+ natural regulatory T cells as antitumor immune effectors in carcinomas of breast and lung. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2794. doi:10.1158/1538-7445.AM2014-2794
Reproducibility of liver iron concentration measured on a biopsy sample: A validation study in vivo
Authors: Silvana Anna Maria Urru, Igor Tandurella, Mario Capasso, Emilio Usala, Donatella Baronciani, Claudio Giardini, Giuseppe Visani, Emanuele Angelucci
Journal: American Journal of Hematology (2014)

Determination of liver iron concentration is essential to predict iron related tissue damage and to guide chelation therapy. To assess the reliability of a single biopsy iron concentration determination in representing the whole liver iron concentration, we conducted a prospective study performing two immediately successive liver biopsies from 61 noncirrhotic, iron overloaded thalassemia patients, directing the needle to different direction from the same skin cut. The correlation among sample biopsies was determined by both regression analysis and the Bland-Altman method. The results showed that overall correlation between the two samples was high (Pearson's coefficient of correlation r = 0.970, P < 0.0001; 95% CI 0.951-0.981; R(2) = 0.941). To evaluate if sample dimension had an impact on the analysis we analyzed separately biopsy couples were both sample gross weight were ≥1 mg dry weight (n = 16) from the others [one or both had a specimen gross weight <1 mg dry weight (n = 45)]. In the first case, correlation coefficient r was equal to 0.998 (P < 0.0001; 95% CI: 0.995-0.999; R(2) = 0.996) while in the latter was 0.960 (P < 0.0001; 95% CI: 0.928-0.977; R(2) = 0.921). In no instance second specimen prediction interval was outside the interval implying different prognostic and therapeutic decision if both liver samples gross weight were ≥1 mg dry weight. The Bland-Altman plot analysis showed the same trend observed using Pearson's correlation coefficient in the analyzed sample categories. Hepatic iron concentration determined in "good quality" biopsy specimen (i.e. sample gross weight ≥1 mg dry weight) is a reliable indicator of whole liver iron concentration.
Original article: <i>Myrmecia pilosula</i> (Jack Jumper) ant venom: identification of allergens and revised nomenclature
Authors: M. D. Wiese, S. G. A. Brown, T. K. Chataway, N. W. Davies, R. W. Milne, S. J. Aulfrey, R. J. Heddle
Journal: Allergy (2007)

Background: The ‘Jack Jumper Ant’ (JJA; Myrmecia pilosula species complex) is the major cause of ant sting anaphylaxis in Australia. Our aims were to determine the allergenicity of previously described venom peptides in their native forms, identify additional allergens and if necessary, update nomenclature used to describe the allergens according to International Union of Immunological Societies criteria. Methods: Various polyacrylamide gel electrophoresis methods were used to separate JJA venom. Gel resolved venom was Western‐blotted and probed with individual sera taken from patients with a history of JJA sting anaphylaxis and immunoglobulin E radioallergosorbent test (IgE RAST) tracer uptakes of &gt;1% to whole venom. Results: Of 67 available sera, 54 had RAST uptakes &gt;1%. Thirteen IgE binding bands were identified using these sera. Pilosulin 3, [Ile 5 ]pilosulin 1, and pilosulin 4.1 were recognized by 42 (78%), 18 (33%) and nine (17%) of the 54 sera that were tested. Immunoglobulin E‐binding proteins with estimated molecular masses of 6.6, 22.8, 25.6, 30.4, 32.1, 34.4 and 89.8 kDa were each recognized by three or more individual sera. Two of these (25.6 and 89.8 kDa) were recognized by 46% and 37% of sera, respectively. Conclusion: Nomenclature used to describe JJA venom allergens has been revised. Pilosulin 3 (Myr p 2) is the only major allergen, whilst [Ile 5 ]pilosulin 1 (Myr p 1), and pilosulin 4.1 (Myr p 3) are minor allergens. There are an additional five IgE‐binding proteins that require further characterization before they can be named as allergens. These findings provide a framework for standardizing venom extracts for diagnosis and immunotherapy.
No demonstrable association between the Leningrad–Zagreb mumps vaccine strain and aseptic meningitis in a large clinical trial in Egypt
Authors: H.J. Sharma, S. Aly Oun, S.S. Abou Bakr, S.V. Kapre, S.S. Jadhav, R.M. Dhere, S. Bhardwaj
Journal: Clinical Microbiology and Infection (2010)
Concordance for Vienna Classification Characteristics in monozygotic twins with Crohn’s disease : a Danish-Swedish cohort study of IBD twins
Authors: Tine Jess, Jonas Halfvarson, L. Bodin, C. Tysk, G. Järnerot, V. Binder
Journal: Gut (2004)

Concordance for Vienna Classification Characteristics in monozygotic twins with Crohn’s disease : a Danish-Swedish cohort study of IBD twins
Tuberculosis in Incarcerated Youth in Texas
Authors: William Leigh Risser, Kim Connelly Smith
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chlorhexidine Gluconate, 4%, Showers and Surgical Site Infection Reduction
Authors: Zeinab M. Alawadi, Lillian S. Kao
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Health Education in Rural Schools and Communities
Authors: Nina B. Lamkin
Journal: JAMA (1946)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis
Authors: Peter Klivenyi, Robert J. Ferrante, Russell T. Matthews, Mikhail B. Bogdanov, Autumn M. Klein, Ole A. Andreassen, Gerald Mueller, Marieke Wermer, Rima Kaddurah-Daouk, M. Flint Beal
Journal: Nature Medicine (1999)
Characterization of Monoclonal Antibodies That Recognize Canine CD34
Authors: Peter A. McSweeney, Katherine A. Rouleau, Philip M. Wallace, Benedetto Bruno, Robert G. Andrews, Ljiljana Krizanac-Bengez, Brenda M. Sandmaier, Rainer Storb, Elizabeth Wayner, Richard A. Nash
Journal: Blood (1998)
The genetics of Alzheimer's disease
Authors: J. Edwardson, C. Morris
Journal: BMJ (1998)

The genetics of Alzheimer's disease is proving to be complex and controversial. Nature Genetics this month contains a paper from Tanzi's group in Boston suggesting that a common polymorphism of α2macroglobulin is associated with a major increase in the risk of developing late onset Alzheimer's disease.1 The data generated heated debate at the sixth international conference on Alzheimer's disease held in Amsterdam at the end of July. At least 70 other reports on the genetics of Alzheimer's disease were presented, implicating over a dozen other genes or genetic loci.2 So what is our current state of knowledge?

Missense mutations in three genes are known to cause autosomal dominant forms of early onset Alzheimer's disease: these are the amyloid precursor protein gene located on chromosome 213 and genes for presenilin 1 and presenilin 2 located on chromosomes 14 and 1, respectively. 4 5Studies on these missense mutations have given strong support to the “amyloid cascade hypothesis” of Alzheimer's disease.6 The amyloid precursor protein …
Fever: Basic Mechanisms and Management
Authors: Philip A. Mackowiak
Journal: Annals of Internal Medicine (1991)

History of clinical thermometry clinical thermoregulators thermoregulation the normal tempterature circadian rhythms pyrogenic cytokines and the febrile reponse hyperthermia fever - blessing or curse? fever therapy antipyresis fever patterns relationships between temperature and severity of illness fever in children fever in the elderly fever in HIV-infected patients fever in immunosuppressed patients fever of unknown origin.
Abstract ES1-2: Reconstruction for the high risk patient: challenges of chemotherapy, radiation therapy and patient selection
Authors: Mehra Golshan
Journal: Cancer Research (2015)

Abstract Breast surgical oncology and breast reconstruction are intimately integrated into the multi-disciplinary management of women with breast carcinoma. The primary goal of care for the breast surgical oncologist and reconstruction surgeon remains the optimal treatment of the breast cancer, while the reconstruction surgeon strives to achieve a soft, symmetric, sensate and scar free breast mound. Factors that must be accounted for include the unpredictable nature of radiated structures and the inability to reliably determine the need for radiation. Next the timing or sequencing of chemotherapy and targeted therapy must be adequately addressed in relation to healing before or after surgery. Patient factors such as age, body habitus, donor site availability and institutional expertise are integral in the decision making process. Finally, the patient's lifestyle and preferences must be counterbalanced with co-morbidities, donor site availability and limitations in implant size and shape. Citation Format: Mehra Golshan. Reconstruction for the high risk patient: challenges of chemotherapy, radiation therapy and patient selection [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr ES1-2.
Abstract 12611: Moderate to Severe Acute Kidney Injury Provides the Additional Long-Term Prognostic Information to the Blood Urea Nitrogen to Creatinine Ratio in Patients Admitted With Acute Decompensated Heart Failure
Authors: Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Shunsuke Tamaki, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Tsutomu Kawai, Satoshi Takahashi, Masashi Ishimi, Hideyuki Hakui, Tatsuhisa Ozaki, Yoshihiro Satoh, Masahiro Seo, Masatake Fukunami
Journal: Circulation (2014)

Backgrounds: Elevated blood urea nitrogen to creatinine ratio (BUN/Cr), a surrogate for renal neurohumoral activation, is a marker of mortality in patients with heart failure. Acute kidney injury (AKI) during heart failure treatment is also associated with poor outcome in patients admitted with acute decompensated heart failure (ADHF). However, there is little information available on the long-term prognostic significance of AKI, relating to BUN/Cr in ADHF patients. Methods and Results: We studied 305 consecutive ADHF patients discharged with survival. We defined high BUN/Cr as top tertile at the admission (&gt;24.0). AKI during ADHF treatment was defined according to AKI Network criteria (stage 1, ≥0.3mg/dl absolute or 1.5- to 2.0-fold relative increase in serum creatinine level (s-Cr); stage 2, &gt;2- to 3-fold increase in s-Cr; stage 3, &gt;3-fold increase in s-Cr or s-Cr≥4.0mg/dl with an acute rise of ≥0.5mg/dl). During a follow-up period of 4.2±3.2 yrs, 69 patients had cardiovascular death (CVD). At multivariate Cox analysis, BUN/Cr (p=0.01) and AKI (p=0.0005) were significantly associated with CVD, independently of age, systolic blood pressure, serum sodium and hemoglobin levels and estimated glomerular filtration rate. Irrespective of high or low BUN/Cr, patients with stage 2 or 3 AKI (adjusted hazard ratio(HR): 6.9 (95%CI 1.5 to 30.4) in high BUN/Cr group, 2.9 (95%CI 1.1 to 7.7) in low BUN/Cr group) had the significant increased CVD risk, compared to patients with no AKI. On the other hand, although patients with stage 1 AKI had the significant increased CVD risk (adjusted HR: 3.8 (95%CI 1.5 to 9.7) in high BUN/Cr group, there was no significant difference in CVD risk between patients with stage 1 AKI (adjusted HR: 0.6 (95%CI 0.3 to 1.2) and no AKI in low BUN/Cr group. Conclusion: Moderate to severe AKI during heart failure treatment would provide the additional long-term prognostic information to BUN/Cr in ADHF patients.
Cajal on the Cerebral Cortex: An Annotated Translation of the Complete Writings
Authors: Edward G. Jones, Neely Swanson, Larry W. Swanson, E. Horne Craigie, Juan Cano
Journal: Annals of Internal Medicine (1989)

Reviewsoverdue.Relying on highly selective published extracts from Haeckel's archive is unsatisfactory because of the biases of various editors.Use of Haeckel's extensive correspondence and other materials, such as newspaper clippings, would have given Sandmann
Cyclooxygenase-2 Is a Target of KRASD12, Which Facilitates the Outgrowth of Murine C26 Colorectal Liver Metastases
Authors: Niels Smakman, Onno Kranenburg, Jan M. Vogten, Alexander L.A. Bloemendaal, Paul van Diest, Inne H.M. Borel Rinkes
Journal: Clinical Cancer Research (2005)

Mutational activation of the KRAS oncogene and overexpression of cyclooxygenase-2 (COX-2) contribute to colorectal carcinoma (CRC) development, but the relationship between these two events is unclear. This study was designed to clarify that relationship and to assess the contribution of KRAS-dependent COX-2 to the seeding of CRC cells in the liver and to their outgrowth as liver metastases in an experimental mouse model.The effect of RNA interference-mediated KRAS knockdown on COX-2 expression and activity was tested in murine C26 CRC cells. The contribution of KRAS-dependent COX-2 to early metastatic tumor cell seeding (by intravital microscopy) and outgrowth of metastases in the liver (by bioluminescence imaging) was studied by using parecoxib, a novel and highly selective liver-activated COX-2 inhibitor. Intratumoral cell proliferation, apoptosis, and tumor-associated angiogenesis were assessed by immunohistochemistry on liver tissue sections.Stable knockdown of mutant KRAS(D12) in murine C26 CRC cells by RNA interference lead to a dramatic reduction of COX-2 synthesis and prostaglandin E2 production. Inhibition of host or tumor cell COX-2 activity had no effect on early metastatic cell seeding in the liver but greatly reduced intrahepatic tumor cell proliferation and the rate of liver metastasis outgrowth. COX-2 inhibition had no effect on early tumor vascularization or on tumor cell apoptosis.The high levels of COX-2 enzyme and prostaglandin production in C26 CRC cells are primarily caused by the presence of endogenous mutant KRAS(D12). Furthermore, COX-2 inhibition affects the tumoral rather than the vascular compartment during the early stages of C26 liver metastasis outgrowth.
Arterial hypertension (AH) and endothelial function (EF) in patients with COPD
Authors: Tetyana Pertseva, Natalia Yefimova, Kateryna Gashynova
Journal: European Respiratory Journal (2011)

Objective:  To investigate the influence of co-morbid AH at the EF in patients with COPD.   Materials and methods:  A total of 41 men with stable COPD stages I-was observed. Mean age – 61,41±1,41 years, mean disease duration – 6,15±0,58 years. Group I consisted of patients without concomitant AH – 21 patient, Group II - with AH – 20 patients. Pulmonary function was evaluated by spirograph MasterLab (Jeger, Germany), endotelin-1 plasma level (ET-1) – by reagents “Diameb ®” (DRG, USA), the concentration of exhaled NO (FeNO) – by Niox Mino (Aerocrine, Sweden), Sa O2 – by pulse oxymeter (NONIN, USA).   Results:  Both groups were comparable. In Group II the concentration of FeNO was significantly higher than in group I (14,81±1,59 ppb and 9,75±1,41 ppb, respectively (p   0,05)). In group II the level of ET-1 significantly correlated with Sa O2 (r = -0,38, p = 0.025). We didn9t found any significant correlation between EF and airflow obstruction.   Conclusions:  High concentration of FeNO in COPD patients indicates the presence of more pronounced endothelial dysfunction in patients with concomitant AH; plasma levels of ET-1 in patients with COPD does not depend on concomitant AH; plasma levels of ET-1 increases with an increase in hypoxia in patients with COPD only if there is concomitant AH;  NO concentration in exhaled air and plasma levels of ET-1 in patients with COPD, regardless of the presence of an accompanying AH, does not correlate with indices of airflow obstruction.
1036. Effective Acceleration of Wound Healing by Simultaneous Transfestion of Hepatocyte Growth Factor Gene and Prostacyclin Synthase Gene Using Shima Jet
Authors: Yasuo Kunugiza, Naruya Tomita, Tetsuya Tomita, Hideo Hashimoto, Keita Yamasaki, Hiromi Koike, Hideki Yoshikawa, Ryuichi Morishita
Journal: Molecular Therapy (2004)

Background: Gene delivery into skin may be useful for treating skin diseases. We tried to evaluate the effectiveness of intradermal injection of naked plasmid into the skin by spring powered jet injector, Shima Jet, that was originally developed as non-needle jet injector of insulin for diabetic patients. Recently, there have been a lot of interests in the role of Hepatocyte Growth Factor (HGF) for wound healing. Re-epithelialization and granulation formation induced by HGF would promote the wound closure. On the other hand, the role of Prostagrandin I2 (Prostacyclin) in the vasolidation of blood vessels has been focused on and the effctiveness of Prostagrandin I2 Synthetase (PGIS) gene therapy for promoting blood flow has been reported. In this study we evaluated the effectiveness of gene therapy for healing of impaired wound by transfecting these genes together to the skin by Shima Jet.