tbuckley/cabot-search huggingface dataset:
An Unusual Sequel to Blood Transfusion
Authors: G. Robinson
Journal: BMJ (1941)

Encephalomyelitis in a Case of Pink DiseaseAlthough the symptoms and signs of pink disease are well known the cause is not yet established.Rocaz, however (Pink Disease, 1933, p. 129, supports the idea of an encephalitis due to a neurotropic virus.When it is considered that outbreaks of the disease take the form of individual cases scattered through any one area, the disease certainly does resemble poliomyelitis and polio-encephalitis in some respects.There is, however, little evidence of direct transmission from one child to another, and it is not usual for two members of a family to be affected.Another curious point to note is that the outbreaks are often limited to industrial areas, and occur among the children of the artisan class, although there is no observable relation to poverty.It is notable, too, that the disease only affects young children.The following case is interesting in that the necropsy supports the idea that an encephalomyelitic lesion was the cause of the symptoms and signs. CASE REPORTA child aged 1 year, one of a family of seven children, came from an industial area; the father was a meter collector earning £2 18s. a week.The child had had infantile eczema for six months, and had been losing weight for the past fort- night.He had been breast-fed, but weaned on to cows' milk, gravy, potatoes, milk puddings, etc. Had been suffering from diarrhoea for two weeks, with green foul-smelling stools.Had a cough for a week; no vomiting.Also suffering from insomnia, and profuse sweating especially in the head region.Condition on A dnission.-Thechild was somewhat dehydrated, and showed great hypotonia of the muscles, with flaccidity and wasting.-Therewas a rash, typical of pink disease, on the trunk, face, and legs.The child was irritable, scratching and rubbing the affected areas continually.The hands and feet were cold, pink, and shining.There was some desquamation.The general appearance suggested a case of pink disease of considerable severity and duration.Chest: poor resonance at both bases, with fine rales.Tongue furred.Abdomen retracted.
Recovery from Sterility after Mumps Orchitis
Authors: B. Sandler
Journal: BMJ (1954)

Recovery from Sterility after Mumps OrchitisThe following cases would appear to be unique both in recovery from azoospermia after mumps orchitis and also in that conception occurred in the presence of severe oligospermia.CASE 1 The patient, aged 34, was married on December 8, 1945, his wife being aged 35, and a daughter was born on Sep- tember 18, 1946.He developed mumps in July, 1948, with bilateral orchitis, followed by azoospermia, which persisted for over a year, as recorded in four consecutive semen analyses.There was no loss of hair, change of voice, or alteration in weight or libido to indicate any other endo- crine dysfunction.On May 28, 1949, for the first time, 50,000 spermatozoa per ml.were present, but there was no motility.There were 27% abnormal types, but no pus cells were present.On October 23 hormone assay revealed urinary ketosteroids as
Man-Made Lakes and Human Health
Authors: Colin McCord
Journal: JAMA (1976)

Major technological change cannot take place without corresponding changes in the environment and in human health. In no situation is this more evident than in the massive ecological disturbances that follow construction of large dams, impounding enormous quantities of water. This has been particularly evident in the tropics, but temperate countries are not immune—there were epidemics of malaria in Tennessee in TVA days. <i>Man-Made Lakes and Human Health</i>is the most comprehensive review of this subject that has been produced to date. Included are articles on the diseases affected by new water systems (schistosomiasis, malaria, onchocerciasis, and arbovirus diseases are the most important); separate articles on ten specific dams or irrigation projects; a section on specific ecological factors (insect vectors, molluscs, eutrophication, etc); and a concluding series on the human response to ecological change. The 31 authors comprise a well-balanced selection of medical scientists, engineers, biologists, and others. This broad
RESPONSE: Re: Neoadjuvant Versus Adjuvant Systemic Treatment in Breast Cancer: A Meta-Analysis
Authors: Davide Mauri, Nicholas Pavlidis, John P. A. Ioannidis
Journal: JNCI Journal of the National Cancer Institute (2005)

The meta-analysis by Mauri et al. ( 1 ) from nine neoadjuvant trials is important given the confl icting evidence from published studies.However, we would like to make two points that arise from this analysis.First, to establish the benefi t of neoadjuvant therapy over adjuvant therapy, treatment regimens in the two arms should be identical in terms of drugs used and in terms of scheduling.Mauri et al. acknowledge that postoperative chemotherapy was administered to patients randomly assigned to the neoadjuvant arm in approximately half of studies ( 2 -5 ) , representing approximately a quarter of the dataset pooled (986 patients).This sizeable proportion may have biased results in favor of adjuvant therapy.Ideally, these studies should have been excluded from pooling, but this exclusion would have resulted in pooled data available on only 2960 patients, of which a few more than half (1523 patients) would have been from a single study ].Data from sensitivity analysis with and without the four studies ( 2 -5 ) in which patients received both adjuvant and neoadjuvant chemotherapy should be obtained to assess their potential impact on the primary outcomes assessed and the robustness of the authors' conclusions.Second, Mauri et al. focused on the inability of neoadjuvant chemotherapy to improve any of the primary outcomes assessed, compared with adjuvant therapy, but this analysis should be recognized as a success.Data presented show the clear superiority of neoadjuvant therapy in breastconserving surgery, an important issue for many patients.Furthermore, the ability to obtain tumor tissue by core biopsy before and during neoadjuvant therapy, in addition to the surgical specimen itself, offers a major opportunity for translational research.
Liver transplantation for acute-on-chronic liver failure from erythropoietic protoporphyria
Authors: Pyoung-Jae Park, Shin Hwang, Young-Il Choi, Young-Dong Yu, Gil-Chun Park, Sung-Won Jung, Sam-Youl Yoon, Gi-Won Song, Tae-Yong Ha, Sung-Gyu Lee
Journal: Clinical and Molecular Hepatology (2012)

Erythropoietic protoporphyria (EPP) is an inherited disorder of the heme metabolic pathway that is characterized by accumulation of protoporphyrin in the blood, erythrocytes, and tissues, and cutaneous manifestations of photosensitivity, all resulting from abnormalities in ferrochelatase (FECH) activity due to mutations in the FECH gene. Protoporphyrin is excreted by the liver, and excess protoporphyrin leads to cholelithiasis with obstructive episodes and chronic liver disease, finally progressing to liver cirrhosis. Patients with end-stage EPP-associated liver disease require liver transplantation. We describe here a 31-year-old male patient with EPP who experienced acute-on-chronic liver failure and underwent deceased-donor liver transplantation. Surgical and postoperative care included specific shielding from exposure to ultraviolet radiation to prevent photosensitivity-associated adverse effects. The patient recovered uneventfully and was doing well 24 months after transplantation. Future prevention and treatment of liver disease are discussed in detail.
Ketoconazole and the Yeast Connection
Authors: John P. Quinn
Journal: JAMA (1986)

<h3>To the Editor.—</h3> During the past 12 weeks we have seen in consultation four young women with an iatrogenic illness that we had not encountered previously. In conversations with other infectious disease specialists at other local institutions, we learned of five similar cases during the past six months (oral communication, March 1986). All four of our patients were young women with nonspecific complaints including chronic fatigue, anxiety, and depression. All had normal physical examination findings and screening laboratory study results, including blood cell counts, serum chemistry studies, and erythrocyte sedimentation rates. A unifying feature in all of these cases was that all four women believed that they had disseminated candidiasis and were taking ketoconazole or nystatin, which had been prescribed by their family physicians. None of these patients had any clinical presentations compatible with invasive fungal infection. All had recently read a book entitled<i>The Yeast Connection</i>.<sup>1</sup>In fact,
Aspirin and Reye's Syndrome
Authors: James P. Orlowski
Journal: JAMA (1983)

To the Editor.—  As one of the institutions that participated in the Ohio State study on Reye's syndrome and medication use, I am somewhat confused about the results of the study by Dr Thomas Halpin and co-workers in the Aug 13 issue of The Journal (1982;248:687).  During the study period of December 1978 through March 1980, we reported to the Ohio Department of Health five cases of patients with Reye's syndrome, two of whom had no history of aspirin ingestion. The article stated that during this study period, of the 97 patients with Reye's syndrome, only three had no history of aspirin ingestion. I find it somewhat difficult to believe that two of the three patients with Reye's syndrome who had no history of aspirin ingestion were from a single institution, namely, the Cleveland Clinic. Likewise, the article states that during the period of December 1978 through March 1980, all
Spontaneous Migration of Gallstones
Authors: P. Richards
Journal: New England Journal of Medicine (1962)

ONLY 7 documented cases of the spontaneous disappearance of gallstones are recorded.1 It is most unlikely that this is in fact such a rare phenomenon. It is of particular interest, however, to know whether gallstones can pass spontaneously without colic or jaundice, in the absence of a fistula.Case ReportA 59-year-old woman was admitted to St. George's Hospital in October, 1960, having had attacks of epigastric pain immediately after meals, associated with vomiting and loose stools for 3 weeks. The steady, severe pain radiated to the right shoulder and was relieved by vomiting. She had never been jaundiced, and . . .
P666Heart rate control protects against ischemia-reperfusion injury
Authors: V Delgado Betancourt, A Covihnes, P Mesirca, I Bidaud, J Nargeot, C Piot, J Striessnig, ME Mangoni, S Barrere-Lemaire
Journal: Cardiovascular Research (2014)

Acute myocardial infarction (AMI) is the major cause of cardiovascular mortality worldwide. Early reperfusion is the only treatment recommended to reduce infarct size (IS). However, reperfusion presents also deleterious effects such as ischemia-reperfusion (IR) injury due to irreversible apoptotic death of cardiomyocytes. Most ischemic episodes are triggered by an increase in heart rate (HR) that induces an imbalance between myocardial oxygen delivery and consumption. The BEAUTIFUL clinical trial has demonstrated that moderate HR reduction diminishes the frequency of AMI episodes in patients with stable coronary artery disease and increased HR at rest. The HCN-mediated If current and the Cav1.3-mediated L-type Ca2+ currents play important roles in the generation of automaticity and HR, therefore they are interesting targets for selective control of HR and cardioprotection during AMI.
EXFOLIATIVE DERMATITIS FOLLOWING INTRAVENOUS INJECTION OF COLLOIDAL SULPHUR, WITH RECOVERY
Authors: Norman Tobias
Journal: JAMA (1934)

Primary dermatitis exfoliativa (Hebra) is rare and recovery is unusual. The secondary exfoliative dermatoses (Brocq) usually occur during the treatment of such common skin disorders as psoriasis, seborrheic dermatitis, extensive eczema, lichen planus and lupus erythematosus. This complication may supervene in certain individuals, possibly as a form of allergic response during therapy, which may be local (mercury, chrysarobin, iodoform), internal (quinine) or parenteral (antitoxins, serums, arsenicals, heavy metals). Colloidal Sulphur (Doak) has been recently advocated for chronic arthritis, neuritis, sciatica, arsenical dermatitis and seborrheic eczema. Each 2 cc. ampule represents 5 mg. of sulphur and injection is made intravenously semiweekly. <h3>REPORT OF CASE</h3> Mrs. E. M., aged 26, seen in January 1933, had a chronic seborrheic dermatitis consisting of large subacutely inflamed patches on the back of the neck, left infraclavicular region, left gluteal region and right thigh. The lesions began to appear six years before and, although various ointments
Patient Mix and Utilization of Resources-Reply
Authors: Sheldon Greenfield
Journal: JAMA (1993)

<h3>In Reply.</h3> —Mr Louis and Dr Gonnella are right to be concerned about diagnostic accuracy. All measures of case mix are subject to error. We did extensive preliminary studies comparing physicians' reports, patients' reports, and independent clinical examinations for many tracer diagnoses, complications, and comorbidities. In general, we found that doctor-reported tracer diagnoses (eg, "the patient has diabetes") correlated better with relevant laboratory data (eg, glycosylated hemoglobin) than diagnostic information obtained from self-administered patient questionnaires or from face-to-face interviews conducted by a nurse-researcher. Using multiple reports from various sources to establish a gold standard, the specificity of physicians' tracer diagnosis reports was above 0.90 for diabetes and recent myocardial infarction, just under 0.90 for hypertension, and about 0.65 for congestive heart failure. The accuracy of physicians' reports was similarly good for complications. Physicians' reports of diabetic foot problems were the best predictor of impaired foot sensation by bioesthesiometry; doctor-reported diabetic
Prognostic impact of <i>RAS</i> mutations in patients with myelodysplastic syndrome
Authors: Aref Al‐Kali, Alfonso Quintás‐Cardama, Raja Luthra, Carlos Bueso‐Ramos, Sherry Pierce, Tapan Kadia, Gautam Borthakur, Zeev Estrov, Elias Jabbour, Stefan Faderl, Farhad Ravandi, Jorges Cortes, Ayalew Tefferi, Hagop Kantarjian, Guillermo Garcia‐Manero
Journal: American Journal of Hematology (2013)

RAS is an oncogene frequently mutated in human cancer. RAS mutations have been reported in 10–15% of cases of acute myeloid leukemia (AML) but they appear to be less frequent among patients with myelodysplastic syndrome (MDS). The impact of RAS mutations in patients with MDS is unclear. We conducted a retrospective study in 1,067 patients with newly diagnosed MDS for whom RAS mutational analysis was available. Overall, 4% of patients carried mutant RAS alleles. Notably, FLT3 mutations, which were found in 2% of patients, were mutually exclusive with RAS mutations. Patients with RAS mutations had a higher white blood cell count as well as bone marrow blasts compared with patients carrying wild‐type RAS . However, no differences were observed between both groups regarding the risk of AML transformation (9% vs. 7%) and overall survival (395 days vs. 500 days, P = 0.057). In summary, RAS mutations are infrequent in patients with MDS and do not appear to negatively impact their outcome. Am. J. Hematol. 88:365–369, 2013. © 2013 Wiley Periodicals, Inc.
Radiotherapy in Non-malignant Uterine Haemorrhage
Authors: B. Windeyer
Journal: BMJ (1938)

BRITISHthe two countries, but they were of comparable impor- tance, and no other country can claim any sLibstantial share in the credit.The recent advances in anaesthesia are, however, divided between Canada, the United States, and Germany.The change in our country's position is regrettable.I would suggest that what is needed is an organization of the methods of study of anaesLhetics that will permit the accurate estimation of the valie of new methods, which, even if they do not provide any sensa- tional advance, yet may be a significant improvement on established methods.
Vascular gene delivery of anticoagulants by transplantation of retrovirally-transduced endothelial progenitor cells
Authors: D Griese
Journal: Cardiovascular Research (2003)

Objective: Recent studies have documented the presence of bone marrow-derived endothelial progenitor cells (EPC) in the circulation of several species. This study was designed to evaluate the use of engineered EPC for vascular gene delivery into angioplasty-induced arterial lesions. Methods and Results: EPC could easily be isolated from whole bone marrow and peripheral blood of adult rats. Differentiation was induced by culture on fibronectin in the presence of endothelial specific growth factors. Rat EPC shared several phenotypic and functional properties with mature endothelial cells. Recombinant retroviruses were generated encoding for the anticoagulants tissue-type plasminogen activator (tPA) and hirudin. Efficient (>90%) ex vivo gene transfer could be achieved resulting in high levels of transgene production. Engineered EPC were locally infused into freshly balloon-injured carotid arteries. Analysis of day 7 vessels showed 73±10% luminal coverage of the lesioned arterial bed with transduced EPC. Sustained secretion of both anticoagulants could be detected in organ cultures of explanted arteries. EPC seeding inhibited dilation of the injured arterial segment and prevented reduction of media thickness. However, rapid repopulation with EPC failed to attenuate neointima formation in this model. Conclusions: Peripheral blood and bone marrow can be used as source for endothelial lineage cells. Cultured EPC can be genetically engineered by retroviral gene transfer and serve as cellular vehicles for vascular gene and drug delivery of anticoagulants. Local transplantation of EPC attenuates reendothelialization of angioplasty-injured arteries but fails to inhibit neointima proliferation.
Severe Reactions to Grape, As Part of a Lipid Transfer Protein-Associated Clinical Syndrome
Authors: E. Vassilopoulou, J. Akkerdaas, I. Tassios, N. Rigby, L. Zuidmeer, R. van Ree, C. Mills, P. Saxoni-Papageorgiou, N.G. Papadopoulos
Journal: Journal of Allergy and Clinical Immunology (2006)
Immunologically Privileged Brain Sites
Authors: Israel Penn
Journal: JAMA (1972)

To the Editor.—  In a letter (220:1130, 1972), Dr. J. W. Futrell commented on a previous report concerning the high incidence of brain involvement by lymphomas in renal transplant recipients. 1 He suggested that the reason for this was that the brain was  immunologically privileged site, by virtue of its lack of conventional lymphatic drainage. In all fairness, I should point out that this idea was originally suggested to us 2 in 1970 by Dr. Rupert Billingham of the University of Texas, Southwestern Medical School at Dallas. Later, the whole subject was discussed in detail in a report from our center, 3 and received a further airing in an editorial in The Lancet : 4   At the present time, we have collected data concerning 100 de novo neoplasms that were diagnosed at some time after transplantation in the recipients of two cardiac homografts and 96 renal homografts.  Thirty-three of the
POLIOMYELITIS IN THE CYNOMOLGUS MONKEY
Authors: Harold K. Faber, Rosalie J. Silverberg, Luther Dong
Journal: The Journal of Experimental Medicine (1943)

1. Cynomolgus monkeys were subjected to a series of non-traumatic exposures of the mucous membranes of the alimentary tract, designed to test the relative permeability to poliomyelitis virus of its upper and lower portions. 2. In the first stage, dried poliomyelitis virus of tested potency was administered in fat-covered capsules to 26 monkeys in such a way as to avoid contamination of the oropharynx but to permit thorough exposure of the gastro-intestinal mucosae. No clinical evidence of poliomyelitic infection appeared. 3. Subsequent application of small amounts of virus to the tongues of 18 of the same monkeys caused paralytic poliomyelitis in one of them. 4. Virus given subsequently by enema to 11 of the monkeys caused no clinical manifestations of poliomyelitis. 5. Of 7 monkeys later treated with virus by oronasal spraying, one developed typical preparalytic signs of infection, and the distribution of lesions indicated that entry had occurred through the afferent nerves of the oropharynx and, possibly, the esophagus. 6. The 6 surviving monkeys were exposed to virus by inhalation. One of them developed paralytic poliomyelitis by olfactory entry. The others appeared to have acquired some resistance to infection. 7. The 5 surviving monkeys were inoculated intracerebrally, as a test of immunity. One of them developed paralytic poliomyelitis. The other 4 showed no clinical signs of infection, but all had typical lesions of varying extent and intensity in the central nervous system. 8. A histological examination of the peripheral nervous ganglia in 12 of the exposed monkeys sacrificed at various stages of the experiments revealed lesions compatible with poliomyelitis in all. Ganglia connected with the head alone (Gasserian, cervical sympathetic) were more constantly and, on the average, more severely involved than the celiac, which is connected only with the intestine. 9. While the celiac ganglion was involved in 7 cases, no evidence was found of the spread of infection from it to the spinal cord.
Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain
Authors: Il-Doo Kim, Chae-Moon Lim, Jung-Bin Kim, Hye Yeong Nam, Kihoon Nam, Seung-Woo Kim, Jong-Sang Park, Ja-Kyeong Lee
Journal: Journal of Controlled Release (2009)
Retroperitoneal Sarcoma Mimicking Obstructed Kidney on Tc-99 DTPA Scintigraphy
Authors: Ekaterina Tiktinsky, Tifha Horne, Peter Pirogovsky, Sergey Domchic, Svetlana Agranovich, Sophie Lantsberg
Journal: Clinical Nuclear Medicine (2009)

A 59-year-old woman was referred to our department for Tc-99m DTPA renal scintigraphy, after being admitted to our hospital for surgery, because of a biopsy-proven right retroperitoneal sarcoma. A Tc-99m DTPA study showed a normal left kidney. Progressive tracer accumulation was noted in a well-defined area located in the normal site of the right kidney.
Academic Viability of General Internal Medicine
Authors: SEYMOUR M. GLICK
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 March 1986Academic Viability of General Internal MedicineSEYMOUR M. GLICK, M.D.SEYMOUR M. GLICK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-3-441_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The article by Friedman and Pozen (1) and the accompanying editorial (2) examine carefully the accomplishments and problems of sections of general internal medicine. Various reasons are cited for the relatively poor performance of these sections in research, and remedial programs are suggested.I suggest for consideration another possibility that may well be the fundamental issue and one that is dealt with tangentially, if at all, in the two papers. The nature of good research generally requires focusing on a relatively circumscribed subject. Such research is easier the more one narrows the area of interest and probes...References1. FRIEDMANPOZEN RJ. The academic viability of general internal medicine: the views of department of medicine chairmen. Ann Intern Med. 1985;103:839-44. LinkGoogle Scholar2. KARPFLEVEY MG. Divisions of general internal medicine: accomplishments and needs [Editorial]. Ann Intern Med. 1985;103:456-8. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: SEYMOUR M. GLICK, M.D.Affiliations: Ben-Gurion University of the Negev Beer Sheva 84 105 Israel PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 March 1986Volume 104, Issue 3Page: 441-441KeywordsAcademic medicine ePublished: 1 December 2008 Issue Published: 1 March 1986 PDF downloadLoading ...