tbuckley/cabot-search huggingface dataset:
Low-Dose Iloprost Infusion Improves Insulin Action in Aged Healthy Subjects and NIDDM Patients
Authors: Giuseppe Paolisso, Giosue Di Maro, Anna D'Amore, Nicola Passariello, Antonio Gambardella, Michele Varricchio, Felice D'Onofrio
Journal: Diabetes Care (1995)

OBJECTIVE To investigate the effect of iloprost infusion on insulin action. RESEARCH DESIGN AND METHODS Thirteen healthy subjects and 13 non-insulin-dependent diabetes mellitus (NIDDM) patients matched for age (68.2 ± 0.5 vs. 67.9 ± 0.5 years, NS), gender ratio (7 men:6 women vs. 6 men:7 women), body weight, body fat distribution, arterial blood pressure, and plasma triglycéride levels (1.89 ± 0.09 vs. 1.87 ± 0.08 mmol/l, NS) were studied. In eight healthy subjects and eight NIDDM patients, we studied insulin action by euglycemic glucose clamp (insulin infusion rate 2 mU · kg−1 · min−1) along with saline and iloprost delivery (0.7 ng · kg−1 · min−1). In the other five subjects of each group, forearm blood flow and insulin-mediated glucose uptake during saline and iloprost infusion (0.7 ng · kg−1 · min1) were investigated. RESULTS Iloprost infusion improved insulin-stimulated whole-body glucose uptake and oxidative and nonoxidative glucose metabolism in both study groups. Forearm blood flow under basal conditions and with insulin infusion (2 mU · kg−1 · min−1) did not show any significant difference from that during saline and iloprost infusion (0.7 ng · kg−1 · min−1) in healthy subjects and diabetic patients. CONCLUSIONS Iloprost infusion improves insulin action in healthy subjects and NIDDM patients.
Physiological analysis to quantify training load in badminton.
Authors: P Majumdar, G L Khanna, V Malik, S Sachdeva, M Arif, M Mandal
Journal: British Journal of Sports Medicine (1997)

To estimate the training load of specific on court training regimens based on the magnitude of variation of heart rate-lactate response during specific training and to determine the magnitude of variation of biochemical parameters (urea, uric acid, and creatine phosphokinase (CPK)) 12 hours after the specific training programme so as to assess training stress.The study was conducted on six national male badminton players. Maximum oxygen consumption (VO2), ventilation (VE), heart rate, and respiratory quotient were measured by a protocol of graded treadmill exercise. Twelve training sessions and 35 singles matches were analysed. Heart rate and blood lactate were monitored during technical training routines and match play. Fasting blood samples collected on two occasions--that is, during off season and 12 hours after specific training--were analysed for serum urea, uric acid, and CPK.Analysis of the on court training regimens showed lactate values of 8-10.5 mmol/l in different phases. The percentage of maximum heart rate ranged from 82% to 100%. Urea, uric acid, and CPK activity showed significant changes from (mean (SD)) 4.93 (0.75) mmol/l to 5.49 (0.84) mmol/l, 0.23 (0.04) to 0.33 (0.06) mmol/l, and 312 (211.8) to 363 (216.4) IU/l respectively.Maximum lactate reported in the literature ranges from 3-6 mmol/l. Comparatively high lactate values and high percentage of maximum heart rate found in on court training show a considerable stress on muscular and cardiovascular system. The training load needs appropriate monitoring to avoid over-training. Workouts that are too intensive may interfere with coordination, a factor that is important in sports requiring highly technical skill such as badminton.
Psychopharmacology in the Practice of Medicine
Authors: John F. Greden
Journal: JAMA (1978)

Nonpsychiatric practitioners currently prescribe most of the 200 million psychotropics dispensed yearly in America. Neuroleptics, tranquilizers, sedatives, hypnotics, antidepressants, stimulants, and even antimanic medications such as lithium carbonate have become routine components of treatment programs for many medical practitioners. Unfortunately, objective assessments repeatedly suggest that prescriptions for psychotherapeutics are often not needed, contraindicated, stopped too soon, continued too long, given in dosages that are inadequate or excessive, prescribed in unnecessary combinations that confuse outcome evaluations, ordered simultaneously with other drugs producing undesirable interactions, not given in the most economical form or at times most likely to guarantee compliance, and on occasion not prescribed at all when they are the treatment of choice. For these reasons, any text that clarifies psychopharmacological principles for medical practitioners is a valuable addition. This text addresses this need. It succeeds commendably. <i>Psychopharmacology in the Practice of Medicine</i>is a collection of 35 chapters written by
Intrinsic radiation resistance of primary clonogenic blasts from children with newly diagnosed B-cell precursor acute lymphoblastic leukemia.
Authors: F M Uckun, W Jaszcz, M Chandan-Langlie, K G Waddick, K Gajl-Peczalska, C W Song
Journal: Journal of Clinical Investigation (1993)

The radiation sensitivity of primary clonogenic blasts from 44 children with newly diagnosed B-cell precursor acute lymphoblastic leukemia (ALL) was analyzed using leukemic progenitor cell (LPC) colony assays. The derived values for SF2 (surviving fraction at 200 cGy) and alpha (initial slope of radiation survival curves constructed according to the linear quadratic model) indicated a marked interpatient heterogeneity in intrinsic radiation sensitivity of LPC populations. The SF2 values ranged from 0.01 to 1.00 (median = 0.430; mean +/- SE = 0.47 +/- 0.04), and the alpha values ranged from 0.000 to 3.272 Gy-1 (median = 0.280 Gy-1; mean +/- SE = 0.430 +/- 0.093 Gy-1). When CD19+ CD34+ versus CD19+ CD34- immunophenotypes were compared, a trend toward higher SF2 and lower alpha values were observed in LPC from CD34+ patients, consistent with greater radiation resistance. When patients were divided into three approximately equal groups based on increasing levels of CD34 expression, a clear ordering effect was observed indicating that increased CD34 expression levels are associated with significantly higher radiation resistance at the level of B-lineage LPC. The highest CD34 expression group (> or = 75% positivity) had 1.4-fold higher SF2 (P = 0.05) and twofold lower alpha values (P = 0.06) than the lowest group (< 30% positivity). Furthermore, the CD34 positivity of radiation resistant (alpha < or = 0.2 and SF2 > or = 0.5) B-cell precursor ALL cases was greater than the CD34 positivity of radiation sensitive (alpha > 0.2 and/or SF2 < 0.5) cases (56 +/- 9% versus 34 +/- 9%, P = 0.09). Whereas only 6 of 16 (38%) of radiation sensitive cases were CD34+, 11 of 15 (73%) of radiation resistant cases expressed CD34 (P = 0.04). Our results offer new insights into the inherent and/or acquired radiation resistance of primary clonogenic blasts from B-cell precursor ALL patients.
STUDIES ON THE IMMUNE RESPONSE OF THE RHEUMATIC SUBJECT AND ITS RELATIONSHIP TO ACTIVITY OF THE RHEUMATIC PROCESS
Authors: Alvin F. Coburn, Ruth H. Pauli
Journal: The Journal of Experimental Medicine (1935)

This study of an isolated colony showed that of seven children who escaped the epidemic streptococcus infection none developed rheumatic symptoms; and that of seventeen children who contracted the epidemic streptococcus infection, fourteen developed acute rheumatism and three showed no recognizable rheumatic manifestations. The seven children who failed to contract infection with Streptococcus hemolyticus showed clearly that susceptible individuals may live in dose association with an epidemic of acute rheumatism, develop no rise in antistreptolysin titer and maintain excellent health. The patient with congenital heart disease demonstrated that a non-rheumatic subject may be infected with a highly effective strain of hemolytic streptococcus, and develop a typical antibody response, yet escape all rheumatic manifestations. The two patients who, although infected with the epidemic strain, failed to show any antibody response, also failed to develop rheumatic recrudescences. Environmental, dietary, age and the other factors investigated did not appear to be significant in this outbreak of acute rheumatism. Three factors appeared to determine the development of the fourteen recrudescences: (1) infection with a highly effective agent; (2) the disease pattern, peculiar to each rheumatic subject; (3) the intensity of the immune response of the patient as indicated by the rise in antistreptolysin titer.
Wavefront aberrations measured with Hartmann-Shack sensor in patients with keratoconus
Authors: Naoyuki Maeda, Takashi Fujikado, Teruhito Kuroda, Toshifumi Mihashi, Yoko Hirohara, Kohji Nishida, Hitoshi Watanabe, Yasuo Tano
Journal: Ophthalmology (2002)
Liver Orcein Stain and Viral DNA in Duck Hepatitis B Virus Infection in Chinese Ducks and Experimentally Infected Japanese Ducklings
Authors: Junko Mori, Masao Omata, Osamu Yokosuka, Fumio Imazeki, Yoshimi Ito, Katsuo Uchiumi, Yasuhisa Matsuyama, Ye Weifa, Kunio Okuda
Journal: Hepatology (1984)

Liver sections were stained with orcein, and duck hepatitis B virus was identified in sera and livers by the hybridization technique in 106 ducks (44 Chinese ducks, 15 Japanese ducks and 47 Japanese ducklings). Orcein-positive hepatocytes were found in 18 of 38 (47%) duck hepatitis B virus DNA seropositive ducks, and only in 3 of 68 (4%) seronegative ducks. The three ducks were all from a heavily infected flock in southern China. Serial analyses of viral DNA by Southern blot and spot hybridizations in experimentally infected Japanese ducklings revealed a dissociation or a time gap between the amount of viral DNA in serum and the emergence of orcein positive hepatocytes. Orcein-positive hepatocytes were generally associated with prolonged presence of viral infection for at least 4 to 6 months. These findings support the clinical hypothesis that the presence of orcein-positive hepatocytes indicates persistent rather than acute infection. Since orcein-positive hepatocytes have been seen in infection with hepatitis B, woodchuck hepatitis, ground squirrel and duck hepatitis B viruses, accumulation of orcein-positive material in liver cells may be one of the common properties these viruses share. This stain may be utilized for screening new hepatitis B virus-like viruses.
Effect of hyperlipidaemia on pulmonary diffusing capacity for carbon monoxide.
Authors: M R Partridge, J M Hughes, G R Thompson
Journal: Thorax (1979)

There is conflicting evidence on the effect of hyperlipidaemia on pulmonary diffusing capacity for carbon monoxide (DLCO or TLCO) in man. We have measured the carbon monoxide transfer factor per unit alveolar volume (TLCO/VA or KCO) by the single breath method in 25 patients with hyperlipidaemia, and in three normal subjects before and after infusions of an intravenous fat emulsion, Intralipid. Non-smokers with hyperlipidaemia had normal levels of TLCO/VA, whereas some of the smokers showed a slight reduction. In neither group was there any correlation of TLCO/VA with serum triglyceride or cholesterol concentrations. A reduction in triglyceride concentrations of up to five-fold produced by plasma exchange (three studies in two patients) or by dietary manipulation (one patient) had no significant effect on the levels of TLCO/VA. Intralipid infusion in three normal subjects caused a four- to five-fold increase in serum triglyceride concentration but had no effect on TLCO/VA. We conclude that moderate degrees of hyperlipidaemia have no effect on pulmonary diffusion.
A NEW ACUTE PHASE PROTEIN ELICITED IN MICE BY STREPTOLYSIN O AND OTHER TOXIC OR INFECTIOUS AGENTS
Authors: Robert Rowen, Myrtle A. Wiest
Journal: The Journal of Experimental Medicine (1965)

A new acute phase plasma component has been found in mice exposed to certain toxic materials and pathogenic bacteria. The abnormal component, detected by immunodiffusion employing absorbed antiserum, was chiefly studied in plasma of streptolysin O-treated mice where it appears within 24 hours after intravenous administration of a sublethal dose of the toxin. The new factor is a protein having the electrophoretic mobility of a slow α2-globulin. It is devoid of lipid and separate from the streptolysin O inhibitory lipoprotein that is also induced by administration of the streptococcal toxin. The factor, moreover, appears clearly distinct from haptoglobin or C-reactive protein and seems to be a unique type of acute phase protein. Its partial purification by starch block electrophoresis is described. A number of toxic materials other than streptolysin O, i.e. saponin, Cl. welchii phospholipase C (α-toxin), and endotoxins, were found to elicit the abnormal protein in mice. Phospholipase A (Crotalus adamanteus venom) and staphylococcal α-toxin failed to cause its appearance. Plasma samples of mice acutely infected with Group A streptococci, Staphylococcus aureus or pneumococcus uniformly contained the abnormal component. The significance of this acute phase protein has been considered in relation to the streptolysin O inhibitor and to the acute phase proteins of other animal species. It has been suggested that production of the new component and of the streptolysin O inhibitor may be manifestations of a single process constituting a physiological response to a variety of deleterious agents.
MAKING BLOOD TRANSFUSION SAFER
Authors: Tracy L. Fisk
Journal: JAMA (1924)

To the Editor:  —A recent editorial inThe Journal(Sept. 29, 1923, p. 1114) sets forth the present status of transfusion accurately. However, I should amend the sentence which says, There are other occasional systemic 'reactions,' varying from slight malaise to severe chills and febrile symptoms, that may give the operator considerable concern. In view of reports from hospitals and operators of high standing, I should make this read, There are other occasional systemic 'reactions,' varying from slight malaise to swift death.  Many lives are saved daily by blood transfusion. From this great total of saved lives we must subtract a number, relatively small, which represents the patients who die as a direct result of the transfusion. I feel that these deaths are preventable, and would suggest four safety measures; namely, divided dosage of blood; extreme accuracy in testing for compatibility; care in selection of method of transfusion; employment of
Effects of Statin Therapy on Arrhythmic Events and Survival in Patients With Nonischemic Dilated Cardiomyopathy
Authors: Jeffrey J. Goldberger, Haris Subacius, Andi Schaechter, Adam Howard, Ronald Berger, Alaa Shalaby, Joseph Levine, Alan H. Kadish
Journal: Journal of the American College of Cardiology (2006)
TCT-469 The Long-term Impact of Antiplatelet Therapy Interruption on Stent Thrombosis Following Percutaneous Coronary Intervention with the Resolute Zotarolimus-eluting Stent
Authors: Ajay J. Kirtane, Sigmund Silber, Sandeep Brar, Stephan Windecker
Journal: Journal of the American College of Cardiology (2013)
Fertility of Male Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study
Authors: Daniel M. Green, Toana Kawashima, Marilyn Stovall, Wendy Leisenring, Charles A. Sklar, Ann C. Mertens, Sarah S. Donaldson, Julianne Byrne, Leslie L. Robison
Journal: Journal of Clinical Oncology (2009)

This study was undertaken to determine the effect of treatment for childhood cancer on male fertility.We reviewed the fertility of male Childhood Cancer Survivor Study survivor and sibling cohorts who completed a questionnaire. We abstracted the chemotherapeutic agents administered, the cumulative dose of drug administered for selected drugs, and the doses and volumes of all radiation therapy from medical records. Risk factors for siring a pregnancy were evaluated using Cox proportional hazards models.The 6,224 survivors age 15 to 44 years who were not surgically sterile were less likely to sire a pregnancy than siblings (hazard ratio [HR], 0.56; 95% CI, -0.49 to 0.63). Among survivors, the HR of siring a pregnancy was decreased by radiation therapy of more than 7.5 Gy to the testes (HR, 0.12; 95% CI, -0.02 to 0.64), higher cumulative alkylating agent dose (AAD) score or treatment with cyclophosphamide (third tertile HR, 0.42; 95% CI, -0.31 to 0.57) or procarbazine (second tertile HR, 0.48; 95% CI, -0.26 to 0.87; third tertile HR, 0.17; 95% CI, -0.07 to 0.41). Compared with siblings, the HR for ever siring a pregnancy for survivors who had an AAD score = 0, a hypothalamic/pituitary radiation dose = 0 Gy, and a testes radiation dose = 0 Gy was 0.91 (95% CI, 0.73 to 1.14; P = .41).This large study identified risk factors for decreased fertility that may be used for counseling male cancer patients.
Correction: Author's Name Omitted
Authors: JAMES W. WILLIAMS
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 September 1986Correction: Author's Name OmittedJAMES W. WILLIAMS, M.D.JAMES W. WILLIAMS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-3-473 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In our article in the June issue, "Biliary Excretion of Aluminum in Aluminum Osteodystrophy with Liver Disease" (1), we inadvertently omitted the name of Genaro M. A. Palmieri, M.D., from the list of contributing authors....Reference1. WILLIAMS J, VERA S, PETERS T, LUTHER R, BHATTACHARYA S, SPEARS H, GRAHAM A, PITCOCK J, and CRAWFORD A [Palmieri GMA]. Biliary excretion of aluminum in aluminum osteodystrophy with liver disease. Ann Intern Med. 1986;104:782-5. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JAMES W. WILLIAMS, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1986Volume 105, Issue 3Page: 473-473KeywordsExcretionLiver diseases ePublished: 1 December 2008 Issue Published: 1 September 1986 PDF downloadLoading ...
Four-Year Follow-up of Palmaz-Schatz Stent Revascularization as Treatment for Atherosclerotic Renal Artery Stenosis
Authors: Gerald Dorros, Michael Jaff, Lynne Mathiak, Isa I. Dorros, Adam Lowe, Kelly Murphy, Thomas He
Journal: Circulation (1998)

Background —Stent revascularization is perceived as superior to balloon angioplasty and surgical revascularization, but the paucity of stent publications precludes even historical comparison with surgical data. Methods and Results —Palmaz-Schatz stent revascularization of renal artery stenosis was successfully performed on 163 consecutive patients for poorly controlled hypertension or preservation of renal function. Of these, 145 were eligible for ≥6-month clinical follow-up of the effect of the procedure on renal function, blood pressure control, number of antihypertensive medications, and survival. At 4 years, systolic and diastolic blood pressures significantly decreased (from 166±26 to 148±22 mm Hg and from 86±14 to 80±11 mm Hg, respectively; P &lt;0.05), and blood pressure control was more facile in approximately half of the patients. Creatinine decreased or remained stable in approximately two thirds of the patients. The cumulative probability of survival was 74±4% at 3 years, with few deaths related to end-stage renal disease. Survival was good in patients with normal (92±4%) baseline renal function, fair (74±7%) in those with mildly impaired renal function, and poor (52±7%) in patients with elevated baseline creatinine levels (≥2.0 mg/dL). The combination of impaired renal function and bilateral disease adversely affected survival. Conclusions —Renal artery stent revascularization in the presence of normal or mildly impaired renal function had a beneficial effect on blood pressure control and a nondeleterious effect on renal function. Survival was adversely affected by renal dysfunction despite adequate revascularization. Early diagnosis and adequate revascularization before the onset of renal dysfunction could beneficially affect blood pressure control, preserve or prevent deterioration of renal function, and improve patient survival.
Identification of HBsAg-specific antibodies from a mammalian cell displayed full-length human antibody library of healthy immunized donor
Authors: Chang-Zheng Li, Zhong-Kun Liang, Zhen-Rui Chen, Hai-Bo Lou, Ye Zhou, Zhe-Huan Zhang, Fei Yu, Shuwen Liu, Yuanping Zhou, Shuguang Wu, Wenling Zheng, Wanlong Tan, Shibo Jiang, Chen Zhou
Journal: Cellular and Molecular Immunology (2011)
Barium Enema with Subsequent Perforation of the Rectum Following Rectoscopic Biopsy
Authors: W. Matek, P. Frühmorgen, H. Fuchs
Journal: Endoscopy (1978)

Two case reports are presented in which a barium enema was carried out immediately following rectal biopsy. In both cases, perforation occurred. On the basis of these cases, the various possibilities of perforation are listed. The question of the time factor when both diagnostic procedures are to be carried out is discussed.
Estrogen Replacement and Risk of Alzheimer Disease
Authors: Mark A. Smith, George Perry, Craig S. Atwood, Richard L. Bowen
Journal: JAMA (2003)

effects of ERT may be related to hormones other than estrogen. In their accompanying Editorial, Drs Resnick and Henderson 4 suggesttheideaofa“criticalperiod”forthetimingofERT. Such a temporal effect might be better explained by changes in the concentrations of gonadotropins during the postmenopausal period. In the early postmenopausal years, serum gonadotropins are extremely elevated but subsequently decline, 2 andthereforeearlyestrogenreplacementmightbemore
Imaging of myocardial infarction in dogs and humans using monoclonal antibodies specific for human myosin heavy chains
Authors: Jocelyne Léger, Jeanine Chevalier, Catherine Larue, Patrick Gautier, Jacques Planchenault, Elisabeth Aumaître, Patrick Messner, Paul Puech, Jean-Claude Saccavini, Bernard Pau, Jean J. Léger
Journal: Journal of the American College of Cardiology (1991)
Researcher into chronic fatigue syndrome is released on bail
Authors: C. Dyer
Journal: BMJ (2011)

Judy Mikovits, the researcher who controversially linked chronic fatigue syndrome with a mouse retrovirus, has been released from jail in California on $100 000 (£64 400; €74 8000) bail after being charged over the disappearance of a laptop and notebooks from the laboratory where she worked.

Police in Reno, Nevada, where she was research director at the Whittemore-Peterson Institute for Neuro-Immune Disease (WPI), are seeking to extradite her on felony charges of “possession of stolen property” and “unlawful taking of computer data, equipment, supplies or other computer-related property.” She was arrested and jailed by police in Ventura County, California, …