tbuckley/cabot-search huggingface dataset:
Abstract 28: Resequence-analysis of 166kb KITLG region in eamilial testicular germ cell tumors
Authors: Charles C. Chung, Meredith Yeager, Joseph Boland, Mark Greene, Stephen Chanock, Christian Kratz
Journal: Cancer Research (2011)

Abstract Recent genome-wide association studies (GWAS) have identified multiple loci associated with testicular germ cell tumor (TGCT) risk, particularly in KITLG on chromosome 12q22, which has the strongest per-allele odds ratio in cancer GWAS to date. KITLG, also known as stem cell factor or Steel, encodes the ligand for the membrane receptor tyrosine kinase, c-KIT. It is notable that mutations in the KIT/KITLG system have been implicated in both testicular cancer development and infertility, both of which are established TGCT risk factors. Therefore, a comprehensive cataloguing of variants around the region is essential for further functional studies. We defined a 166kbps region (chromosome 12: 87371132-87537273) around KITLG, based on linkage disequilibrium patterns and tag analysis using HapMap III CEU and the 1000 genome CEU low-coverage pilot data (July 2010 release). No obvious recombination hotspot was observed within a 1Mb region centered on KITLG. Our study sample set included 10 parent-son trios, of which 6 trios contained 2 familial TGCT cases, 51 familial TGCT cases and 36 sporadic bilateral cases, totaling 117 individuals, all from the National Cancer Institute's Familial Testicular Cancer Study (FTCS). We have catalogued common and rare KITLG variants using deep coverage in next-generation sequencing and also identified haplotypes possibly enriched in familial cases in contrast to normal controls. These study results will facilitate further functional elucidation of TGCT susceptibility loci within this genomic region. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 28. doi:10.1158/1538-7445.AM2011-28
A nanostructured carbon-reinforced polyisobutylene-based thermoplastic elastomer
Authors: Judit E. Puskas, Elizabeth A. Foreman-Orlowski, Goy Teck Lim, Sara E. Porosky, Michelle M. Evancho-Chapman, Steven P. Schmidt, Mirosława El Fray, Marta Piątek, Piotr Prowans, Krystal Lovejoy
Journal: Biomaterials (2009)
Non-specific Suppurative Pneumonia
Authors: A. Logan, H. Nicholson
Journal: Thorax (1949)

In 1938 Scadding described a condition which he called chronic suppurative pneumonia, charac- terized by "irregular consolidation, with inciden- tal breaking down of a small area into an abscess cavity, and the tendency to spread in the form of fresh areas of consolidation which may or may not break down into abscesses."He pointed out that those who have studied large groups of cases of pulmonary abscess find that many abscesses arise without evidence either of aspiration or of embolism, and suggested that some of these should be regarded as chronic suppurative pneumonia.Touroff and Neuhof (1938Neuhof ( , 1941) ) described, under the title of " non-putrid pulmonary abscess," a condition similar to that described by Scadding.They regarded it as being " initiated by aerobic organisms," whereas anaerobic organisms were responsible for the production of acute putrid lung abscess.This separation of abscesses into putrid and non-putrid varieties was accepted by Barrett (1944), but Sellors and others (1946) did not consider it correct.In a series of 27 cases, which they described under the name of spreading suppura- tive pneumonitis, at some time during the illness the sputum was foetid in all but six.The cases in this series showed spreading pulmonary consoli- dation with cavitation, and a cough with purulent
Letter: Postsurgical ulnar neuropathy
Authors: J. S. Barr
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Drs. Murphy and Devers (227:1123, 1974) are correct in emphasizing that one must be alert to avoid the problem of ulnar neuropathy during the time a patient is anesthetized and defenseless. However, in my experience, it is much more common to see this complication occur several days or more postoperatively. The seriously ill patient or the orthopedic patient in traction cannot move much in bed, and often lies with the hands on the abdomen and the elbows flexed. This puts direct pressure on the ulnar groove and the ulnar nerve. Many hospital mattresses are covered with a firm layer of plastic; this adds to the pressure on the ulnar nerve. The condition is diagnosed easily by the location of the symptoms (fourth and fifth fingers) and by tenderness over the ulnar nerve behind the medial epicondyle. It is helpful to place a pillow at the patient's side
The Use of Acetic Acid in Magnification Chromocolonoscopy for Pit Pattern Analysis of Small Polyps
Authors: K. Togashi, D. Hewett, D. Whitaker, G. Hume, L. Francis, M. Appleyard
Journal: Endoscopy (2006)

Background and Study Aims: The role of acetic acid spray during magnification chromocolonoscopy has not previously been evaluated. We aimed to compare the accuracy of predicting polyp histology at magnification colonoscopy, using acetic acid and indigo carmine, either alone or in combination. Patients and Methods: A total of 46 consecutive patients with polyps detected during colonoscopy which measured 10 mm or less were alternately divided into two groups. In group A patients, 1.5 % acetic acid was applied to the mucosa first, followed by indigo carmine spray; in group B patients, the order was reversed. The pit pattern was assessed after application, in real time. All the lesions were resected and examined histologically. Results: Altogether, 37 adenomas and 36 hyperplastic polyps were evaluated. In group A, the diagnostic accuracy after spraying with acetic acid was 95 %, which increased to 98 % after application of indigo carmine. In group B, the accuracy after indigo carmine application was 83 %. After subsequent spraying with acetic acid, images were enhanced in 70 % of patients, with an increase in accuracy to 97 %. The mean time required to obtain an initial clear image with the first dye was 14 seconds for both groups. Conclusions: This is the first description of the use of acetic acid for pit pattern analysis of colonic polyps. Its ease of use, low cost, and safety, together with its excellent accuracy in the assessment of polyp pit patterns suggest that this method could easily be applied to routine magnification colonoscopy.
Sustained improvement in peripheral immune response by biventricular pacing and its association with exercise tolerance and quality of life
Authors: George N. Theodoakis, Panagiota Flevari, Fotis Kolokathis, Efthimios G. Livanis, Stamatis Adamopoulos, Christos Kroupis, Dionyssios Leftheriotis, Aikaterini Koniavitou, Dimitrios T. Kremastinos
Journal: Journal of the American College of Cardiology (2003)
Positive Human Health Effects of Dust Suppression with Canola Oil in Swine Barns
Authors: A. SENTHILSELVAN, Y. ZHANG, J. A. DOSMAN, E. M. BARBER, L. E. HOLFELD, S. P. KIRYCHUK, Y. CORMIER, T. S. HURST, C. S. RHODES
Journal: American Journal of Respiratory and Critical Care Medicine (1997)

A crossover trial was conducted to evaluate the acute human health effects of a dust control technology in a swine confinement facility. Twenty lifetime nonsmoking male subjects, with no evidence of allergy or asthma and no previous swine barn exposure, participated in the study, which included a laboratory session (baseline), 5-h exposure in a swine room sprinkled with canola oil (treatment) and 5-h exposure in a traditional swine room (control). Mean values of inhalable dust concentrations and endotoxin levels in the control room were significantly greater than those observed in the treatment room. Mean shift changes in FEV1 from preexposure to end of exposure were 1.1% (standard error, 0.63%) on baseline day, − 1.9% (0.63%) on treatment day, and − 9.9% (1.12%) on control day; the differences in the shift changes were statistically significant. Mean value of methacholine concentration that reduced the FEV1 by 20% (PC20) in bronchoprovocation tests on baseline day was significantly different from that on treatment day (p = 0.04) and that on control day (p < 0.001). Significant increases were also observed in white blood cell counts and nasal lavage cell counts on the control day in comparison with the other two days. Blood neutrophil counts after control room exposure were twice those observed on baseline and after exposure to the treatment room. Significant differences were also observed in IL-1 β , IL-6, and IL-8 nasal lavage cytokines and in IL-6 serum cytokine. These results suggest that the canola oil dust control method is effective in improving indoor air quality in swine barns and reducing acute health effects in naive healthy subjects.
Parasite impairment by targeting Plasmodium-infected RBCs using glyceryl-dilaurate nanostructured lipid carriers
Authors: Soniya A. Jain, Himanish Basu, Priyanka S. Prabhu, Umangi Soni, Medha D. Joshi, Deepak Mathur, Vandana B. Patravale, Sulabha Pathak, Shobhona Sharma
Journal: Biomaterials (2014)
Patient position during ERCP: prone versus supine. What about left lateral throughout?
Authors: F. Froehlich
Journal: Endoscopy (2006)

I read with interest the article by Terruzzi et al. [1] investigating the safety and effectiveness of patient positioning during endoscopic retrograde cholangiopancreatography (ERCP). Although the study is small, the authors have addressed an important clinical issue. They show that ERCP is more difficult and less often successful when it is conducted with the patient in the supine position in comparison with the prone position.
Pneumonia associated with contact with cyanobacteria.
Authors: P C Turner, A J Gammie, K Hollinrake, G A Codd
Journal: BMJ (1990)

aplastic anaemia is characterised by anaemia, leuco- penia, and thrombocytopenia.The defect is cellular with an increased tendency to infection and bleeding.4Although prejudicial to the success of skin grafting, it is not a contraindication provided deficiencies are corrected perioperatively, haemostasis is achieved before grafting, and the formation of haematoma is avoided afterwards.Each of these children had a chronic cutaneous manifestation ofa haematological or immunodeficiency disease.Healing was assumed to be abnormal because of a defect in either humoral or cellular defence mechanisms.This assumption delayed referral for surgery by some months in each case, but debridement followed by split skin grafting produced rapid healing.
Werner Syndrome in a Korean Man
Authors: Shu Meguro, Yoshihito Atsumi, Kempei Matsuoka, Yuichi Ishikawa, Masanobu Sugimoto, Makoto Goto
Journal: Diabetes Care (2002)

A 34-year-old Korean man living in Tokyo was referred to us in January 1999 for control of his diabetes during cataract surgery. He told us that both disorders had first appeared when he was 22, along with hyperlipidemia. He had acute pancreatitis at 24, and acute appendicitis with peritonitis at 27. He was admitted to a hospital in 1998 for ileus. He has three siblings, the youngest of whom, a sister, had cataracts at 22, and her hair was streaked with gray. His father was diabetic and died at 52 from liver cancer. His mother has …
The Medical Bank Account: Another Look at Health System Reform
Authors: Joel L. Bass
Journal: JAMA (1994)

<h3>To the Editor.</h3> —I present the following proposal for restructuring health insurance that could allow for decreased costs, increased choice, and minimal increase in government bureaucracy and builds on documented effective programs.<sup>1,2</sup> A package of mandated health care benefits is decided on, including both preventive and catastrophic care, to be provided by private insurance companies. Every American would be required to purchase such insurance, either directly or through their employer. There would be no exclusion for preexisting conditions, with community rating based on the national sample. Each policy would have an optional deductible. Each individual adult (or family) would have a medical bank account to which they and/or their employers could make tax-free contributions. This medical bank account would accumulate interest tax free and, prior to Medicare eligibility, could be used only to pay for health care expenses for the adult and his or her dependent children up to
Distensibility Characteristics of the Human Pulmonary Vascular Bed
Authors: PAUL N. YU, GERALD W. MURPHY, BERNARD F. SCHREINER, DOUGLAS H. JAMES
Journal: Circulation (1967)

The changes in pulmonary blood flow, pressure, and volume during supine exercise are studied in seven patients without cardiovascular abnormality, 12 patients with aortic valve disease, 13 patients with mitral valve disease, and five patients with primary myocardial or pericardial disease. The degree of distensibility of the pulmonary vascular bed is assessed by the simultaneous changes in the magnitude of the pulmonary distending pressure (average of pulmonary artery and left atrial pressure) and of the pulmonary blood volume.
Glycemic Control Continues to Deteriorate After Sulfonylureas Are Added to Metformin Among Patients With Type 2 Diabetes
Authors: Michael N. Cook, Cynthia J. Girman, Peter P. Stein, Charles M. Alexander, Rury R. Holman
Journal: Diabetes Care (2005)

OBJECTIVE—To describe the course and predictors of glycemic control among patients with type 2 diabetes after sulfonylureas (SUs) are added to metformin (MF). RESEARCH DESIGN AND METHODS—Patients (n = 2,220) treated with MF monotherapy for &amp;gt;90 days before initiating MF plus SU combination therapy between January 1998 and March 2004 were studied in a retrospective analysis of electronic medical records from U.K. primary care practices using the General Practice Research Database. Median glycoslyated hemoglobin A1c (A1C) before and after SU initiation was described, and patient characteristics were evaluated as predictors of time until A1C ≥8.0% or glucose-lowering therapy was intensified (by starting insulin or adding a third oral agent). RESULTS—At 6 months post-SU initiation, median A1C resumed deteriorating at a somewhat comparable rate to that observed on MF monotherapy. Higher pre-SU A1C, younger age, female sex, shorter diabetes duration, higher serum creatinine, and being an ex-smoker predicted time until A1C ≥8.0% or glucose-lowering therapy was intensified in various analyses. Median A1C was 9.5% when therapy was intensified. A1C ≥8.0% was estimated to occur in 85% of patients 4 years after SU initiation and in 68% 4 years after initially achieving A1C &amp;lt;7% on MF plus SU therapy. CONCLUSIONS—In this population, glycemic control is improved following the addition of SUs to MF, but deterioration resumes as early as 6 months. The high proportion of patients remaining on MF plus SU therapy despite having A1C ≥8.0% suggests that there are significant barriers to starting insulin or adding a third agent when treatment goals are not achieved with this combination.
Evidence implicating nonmuscle myosin in restenosis. Use of in situ hybridization to analyze human vascular lesions obtained by directional atherectomy.
Authors: G Leclerc, J M Isner, M Kearney, M Simons, R D Safian, D S Baim, L Weir
Journal: Circulation (1992)

BACKGROUND Identification of genes that are specifically activated in restenosis lesions after percutaneous transluminal angioplasty represents a necessary step toward molecular manipulation designed to inhibit cellular proliferation responsible for such lesions. Whereas quiescent smooth muscle cells (contractile phenotype) preferentially express smooth muscle myosin, proliferating smooth muscle cells (synthetic phenotype) have been shown to preferentially express nonmuscle myosin in vitro. Accordingly, we analyzed the expression of a recently cloned isoform of human nonmuscle myosin heavy chain (MHC-B) in fresh human restenotic lesions. METHODS AND RESULTS A total of 10 lesions, including four restenosis (three superficial femoral arterial lesions and one saphenous vein bypass lesion) and six primary (four superficial femoral arterial lesions and two coronary arterial lesions) obtained percutaneously by directional atherectomy, were processed for examination by in situ hybridization. In total, 150 tissue sections of restenotic lesions (66 sections), primary lesions (78 sections), and normal internal mammary artery (six sections) were hybridized with the nonmuscle MHC-B probe. Restenotic lesions showed intense hybridization to the nonmuscle MHC-B cRNA probe, as demonstrated by a clustering of more than 20 grains per cell nucleus in 80% of the cells examined within a high-power field (x250); in contrast, an equivalent degree of hybridization was observed in only 7% of cells within primary lesions (p less than 0.001). Results of immunocytochemistry using monoclonal antibody to smooth muscle actin indicated that cells demonstrating strong hybridization were smooth muscle in origin. CONCLUSIONS These findings demonstrate that 1) human vascular tissue obtained by percutaneous directional atherectomy constitutes appropriate biopsy material for gene expression studies at the mRNA level, and 2) nonmuscle MHC-B mRNA is present in greater abundance among restenotic versus primary vascular stenoses. These observations thus provide a rational basis to explore restenotic lesions on a larger scale to identify genes that are activated in these lesions and establish potential targets for future gene therapy.
Transposition of the great arteries: A review of 37 cases after Mustard's operation
Authors: H. N. C. Ihenacho, R. G. Patel, S. P. Singh, R. Astley, C. G. Parsons
Journal: Thorax (1973)

<b>Ihenacho, H. N. C., Patel, R. G., Singh, S. P., Astley, R., and Parsons, C. G. (1973).</b><i>Thorax</i>, <b>28</b>, 448-452. <b>Transposition of the great arteries. A review of 37 cases after Mustard9s operation.</b> Thirty-seven children with transposition of the great arteries have undergone Mustard9s operation in Birmingham Children9s Hospital from May 1968 to December 1971. Thirtythree of these had simple transposition of the great arteries and four were complicated. All but two had some previous palliative procedures. Ten patients died before discharge from hospital and there were two late deaths, one after three months and the other after eight months. Bleeding, dysrhythmia, and hypotension were common immediate postoperative complications, while recurrent heart failure and persistent atrioventricular block occurred in five and four patients respectively.
Amputation and Mortality in New-Onset Diabetic Foot Ulcers Stratified by Etiology
Authors: Probal Moulik, G.V. Gill
Journal: Diabetes Care (2003)

Thyroid DiseaseT ype 1 diabetes is associated with other autoimmune diseases.Many diabetes centers routinely screen patients with type 1 diabetes for autoimmune thyroid disease (ATD).The presence of two autoimmune diseases raises the possibility of polyendocrine autoimmune disease.The association of autoimmune adrenal insufficiency, or Addison's disease, with type 1 diabetes is described in case reports dating back more than a century (1,2).Studies have i l l u s t r a t e d s h a r e d H L A a l l e l e s (DQA1*0501, for example) among patients with type 1 diabetes, ATD, and Addison's disease (3,4).Pancreatic islet cell antibodies have been detected in 6.2% of patients with Addison's disease ( 5).Yet, it is unclear whether patients with type 1 diabetes should be routinely screened for Addison's disease.Our study's objective was to determine whether routine screening for Addison's disease is warranted in children with both type 1 diabetes and ATD.Children were diagnosed with thyroid disease if they had thyroid peroxidase antibodies (TPOs Ͼ50 Ku/l) and/or were receiving thyroid hormone replacement for primary hypothyroidism.A population of children with type 1 diabetes but without thyroid disease was also screened.The study population consisted of 114 children with type 1 diabetes, 35 (25 girls and 10 boys) with thyroid disease (28 on L- thyroxine) and 79 (42 girls and 37 boys) without thyroid disease (normal thyroidstimulating hormone and TPO Ͻ50 Ku/ l).Adrenal antibodies were measured by standard immunofluorescent technique (Nova Century Scientific-Immco antiadrenal slides), and TPOs were measured by an automated electrochemiluminescence immunoassay (Roche Elecsys 2010).
A Randomized Trial of Genotype-Guided Dosing of Acenocoumarol and Phenprocoumon
Authors: Talitha I. Verhoef, Georgia Ragia, Anthonius de Boer, Rita Barallon, Genovefa Kolovou, Vana Kolovou, Stavros Konstantinides, Saskia Le Cessie, Efstratios Maltezos, Felix J.M. van der Meer, William K. Redekop, Mary Remkes, Frits R. Rosendaal, Rianne M.F. van Schie, Anna Tavridou, Dimitrios Tziakas, Mia Wadelius, Vangelis G. Manolopoulos, Anke H. Maitland-van der Zee
Journal: New England Journal of Medicine (2013)

Observational evidence suggests that the use of a genotype-guided dosing algorithm may increase the effectiveness and safety of acenocoumarol and phenprocoumon therapy.We conducted two single-blind, randomized trials comparing a genotype-guided dosing algorithm that included clinical variables and genotyping for CYP2C9 and VKORC1 with a dosing algorithm that included only clinical variables, for the initiation of acenocoumarol or phenprocoumon treatment in patients with atrial fibrillation or venous thromboembolism. The primary outcome was the percentage of time in the target range for the international normalized ratio (INR; target range, 2.0 to 3.0) in the 12-week period after the initiation of therapy. Owing to low enrollment, the two trials were combined for analysis. The primary outcome was assessed in patients who remained in the trial for at least 10 weeks.A total of 548 patients were enrolled (273 patients in the genotype-guided group and 275 in the control group). The follow-up was at least 10 weeks for 239 patients in the genotype-guided group and 245 in the control group. The percentage of time in the therapeutic INR range was 61.6% for patients receiving genotype-guided dosing and 60.2% for those receiving clinically guided dosing (P=0.52). There were no significant differences between the two groups for several secondary outcomes. The percentage of time in the therapeutic range during the first 4 weeks after the initiation of treatment in the two groups was 52.8% and 47.5% (P=0.02), respectively. There were no significant differences with respect to the incidence of bleeding or thromboembolic events.Genotype-guided dosing of acenocoumarol or phenprocoumon did not improve the percentage of time in the therapeutic INR range during the 12 weeks after the initiation of therapy. (Funded by the European Commission Seventh Framework Programme and others; EU-PACT ClinicalTrials.gov numbers, NCT01119261 and NCT01119274.).