THE CLINICAL COURSE, FOLLOWING ADRENAL RESECTION AND SYMPATHECTOMY, OF 82 PATIENTS WITH SEVERE HYPERTENSION
Authors: W A JEFFERS, H A ZINTEL, J H HAFKENSCHIEL, A G HILLS, A M SELLERS, C C WOLFERTH
Journal: Annals of Internal Medicine (1953)

Article1 August 1953THE CLINICAL COURSE, FOLLOWING ADRENAL RESECTION AND SYMPATHECTOMY, OF 82 PATIENTS WITH SEVERE HYPERTENSIONWILLIAM A. JEFFERS, F.A.C.P., HAROLD A. ZINTEL, JOSEPH H. HAFKENSCHIEL, A. GORMAN HILLS, ALFRED M. SELLERS, CHARLES C. WOLFERTH, F.A.C.P.WILLIAM A. JEFFERS, F.A.C.P.Search for more papers by this author, HAROLD A. ZINTELSearch for more papers by this author, JOSEPH H. HAFKENSCHIELSearch for more papers by this author, A. GORMAN HILLSSearch for more papers by this author, ALFRED M. SELLERSSearch for more papers by this author, CHARLES C. WOLFERTH, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-2-254 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONPrevious reports of our testing of operations for hypertension, combining adrenal resection with sympathectomy, have indicated encouraging results.1, 2, 3, 4 The number of patients so treated has increased steadily. We now feel it in order to present a progress report concerning 82 patients who were operated upon prior to December 31, 1952.It does not seem necessary to review again the experimental and clinical evidence indicating the rôle of various adrenal hormones in homeostasis of the circulation, or in the maintenance of blood pressure levels in clinical hypertension.2, 4, 5Following Green's experience6of observing amelioration of severe...Bibliography1. LukensWolferthJeffersZintelHafkenschiel FDCCWAHAJH: Observations on subtotal adrenalectomy in hypertension, Trans. Am. Clin. and Climatol. As. 62: 229, 1950. MedlineGoogle Scholar2. WolferthJeffersLukensZintelHafkenschiel CCWAFDHAJH: Observations on the results of subtotal adrenalectomy in the treatment of severe, otherwise intractable hypertension and their bearing on the mechanism by which hypertension is maintained, Ann. Int. Med. 35: 8, 1951. LinkGoogle Scholar3. ZintelWolferthJeffersHafkenschielLukens HACCWAJHFD: Ninety-five per cent subtotal adrenalectomy for essential hypertension, Surgical Forum (Proc. 36th Clin. Congress Am. Coll. Surg.) 1951, W. B. Saunders Company, Philadelphia, p. 556. Google Scholar4. WolferthJeffersZintelHafkenschielHills CCWAHAJHAG: Effects of subtotal adrenalectomy alone and combined with sympathectomy upon the blood pressure levels and complications of severe arterial hypertension, Bull. New York Acad. Med. 29: 115, 1953. MedlineGoogle Scholar5. Merrill JP: The role of the adrenal in hypertension, Ann. Int. Med. 37: 966, 1952. LinkGoogle Scholar6. GreenNelsonDoddsSmalley DMJNGARD: Bilateral adrenalectomy in malignant hypertension and diabetes, J. A. M. A. 144: 439, 1950. CrossrefMedlineGoogle Scholar7. ThornHarrisonMerrillCriscitielloFrawleyFinkenstaedt GWJHJPMGTFJT: Clinical studies in bilateral complete adrenalectomy in patients with severe hypertensive vascular disease, Ann. Int. Med. 37: 972, 1952. LinkGoogle Scholar8. JeffersSheimanO'Brasky WASCGH: Use of a simple postural test in neurocirculatory asthenia, Am. J. M. Sc. 210: 511, 1945. CrossrefGoogle Scholar9. Smithwick RH: The effect of sympathectomy upon the mortality and survival rates of patients with hypertensive cardiovascular disease, in Hypertension, edited by E. T. Bell, 1951, University of Minnesota Press, Minneapolis, p. 429. Google Scholar10. Wilkins RW: New drug therapies in arterial hypertension, Ann. Int. Med. 37: 1144, 1952. LinkGoogle Scholar11. Hafkenschiel JH: Recent advances in the treatment of severe hypertension, Pennsylvania M. J. 55: 120, 1952. MedlineGoogle Scholar12. WolferthJeffersZintelHafkenschielHillsSellers CCWAHAJHAGAM: Effects of subtotal adrenalectomy with or without sympathectomy upon the course of congestive heart failure, presented before the American Heart Association in Atlantic City, New Jersey, on April 11, 1953. Google Scholar13. HafkenschielFriedlandCrumpton JHCKCW: Subtotal adrenalectomy in essential hypertension; preliminary report of the effects on cerebral hemodynamics and oxygen metabolism (abstract), Am. J. Physiol. 167: 790, 1951. Google Scholar14. Hills AG: Unpublished observations. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Presented at the Thirty-Fourth Annual Session of the American College of Physicians, Atlantic City, New Jersey, April 14, 1953.From the Edward B. Robinette Foundation, Medical Clinic, and the Surgical Service, of the Hospital of the University of Pennsylvania.This investigation was supported in part by research grants from The National Heart Institute, the U. S. Public Health Service, the Squibb Institute of Medical Research, Sandoz Pharmaceuticals, Eli Lilly and Company, Ciba Pharmaceutical Products, Inc., Merck and Company, Inc., and the Publicker Industries Nutritional Fund.†Supplied generously by Merck and Company, Inc. 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REVELL JR., M.D., F.A.C.P., FRANCIS J. BORGES, M.D., GEORGE H. YEAGER, M.D., F.A.C.S., JAMES G. ARNOLD JR., M.D., RICHARD I. AHLQUIST JR., M.D.Quantitative evaluation of primary adrenal cortical deficiency in man 1 August 1953Volume 39, Issue 2Page: 254-266KeywordsBlood pressureHealth services researchHeartHormonesHospitalsHypertensionMedical servicesNutritionResearch grantsSympathectomy ePublished: 1 December 2008 Issue Published: 1 August 1953 PDF downloadLoading ...