THE USE OF ACTH AND CORTISONE IN IDIOPATHIC THROMBOCYTOPENIC PURPURA AND IDIOPATHIC ACQUIRED HEMOLYTIC ANEMIA
Authors: M C MEYERS, S MILLER, J W LINMAN, F H BETHELL
Journal: Annals of Internal Medicine (1952)

Article1 August 1952THE USE OF ACTH AND CORTISONE IN IDIOPATHIC THROMBOCYTOPENIC PURPURA AND IDIOPATHIC ACQUIRED HEMOLYTIC ANEMIAMURIEL C. MEYERS, STANLEY MILLER, JAMES W. LINMAN, FRANK H. BETHELL, F.A.C.P.MURIEL C. MEYERSSearch for more papers by this author, STANLEY MILLERSearch for more papers by this author, JAMES W. LINMANSearch for more papers by this author, FRANK H. BETHELL, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-37-2-352 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptACTH and cortisone have been put to trial in the treatment of a variety of hematologic disorders, to emerge as agents of therapeutic importance in thrombocytopenic purpura and acquired hemolytic anemia. In discussing these conditions it is implied that reference is made to the so-called idiopathic forms of the disease.Thrombocytopenic purpura assumes a variety of clinical forms, varying widely in severity but having in common hemorrhagic manifestations associated with thrombocytopenia, increased capillary fragility, prolonged bleeding time and defective clot retraction. The marrow is active and essentially normal. The clinical course may be acute and fulminating, active but stationary, or...Bibliography1. Doan CA: The etiology and management of the hemorrhagic diatheses, Ann. Int. Med. 31: 967, 1949. LinkGoogle Scholar2. DameshekMiller WEB: The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism, Blood 1: 27, 1946. CrossrefMedlineGoogle Scholar3. HarringtonMinnichHollingsworthMoore WJVJWCV: Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura, J. Lab. and Clin. Med. 38: 1, 1951. MedlineGoogle Scholar4. 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DameshekRosenthalSchwartz WMCLI: The treatment of acquired hemolytic anemia with adrenocorticotrophic hormone (ACTH), New England J. Med. 244: 117, 1951. CrossrefGoogle Scholar10. MeyersMillerBethell MCSFH: Administration of ACTH in hypersplenic syndromes (Abstract), J. Lab. and Clin. Med. 36: 965, 1950. MedlineGoogle Scholar11. BethellMillerMeyers FHSMC: Administration of ACTH and cortisone in hypersplenic syndromes, Proceedings of the Second Clinical ACTH Conference, New York, The Blakiston Co., Philadelphia, 1951, Vol. II, p. 173. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Thirty-third Annual Session of the American College of Physicians, Cleveland, Ohio, April 24, 1952.From the Department of Internal Medicine and The Thomas Henry Simpson Memorial Institute for Medical Research, University of Michigan, Ann Arbor, Michigan. 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BIGNALLAUTOANTIBODIES AND THE HYPER-REACTIVE STATE IN THE PATHOGENESIS OF DISEASEZur Therapie erworbener hämolytischer AnämienThe Use of Corticotropin, Cortisone and Hydrocortisone in General SurgeryCORTICOTROPHIN AND CORTISONE IN IDIOPATHIC THROMBOCYTOPENIC PURPURAPharmacologic Aspects of Adrenocortical Steroids and ACTH in ManDifferential diagnosis, pathogenesis and treatment of the thrombocytopenic purpurasIMMUNOLOGIC MECHANISMS IN IDIOPATHIC AND NEONATAL THROMBOCYTOPENIC PURPURA*WILLIAM J. HARRINGTON, M.D., CHARLES C. SPRAGUE, M.D., VIRGINIA MINNICH, M.S., CARL V. MOORE, M.D., F.A.C.P., ROBERT C. AULVIN, B.S., REUBENIA DUBACH, Ph.D.ACTH and Cortisone in the Treatment of Acquired Hemolytic AnemiaCurrent pediatric references 1 August 1952Volume 37, Issue 2Page: 352-361KeywordsAdrenocorticotropic hormoneBone marrowCapillariesHemolytic anemiaHemorrhageIdiopathic thrombocytopenic purpura ePublished: 1 December 2008 Issue Published: 1 August 1952 PDF downloadLoading ...