Heparin Flushes and Thrombocytopenia
Authors: PETER S. HEEGER
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 July 1986Heparin Flushes and ThrombocytopeniaPETER S. HEEGER, M.D., JAY T. BACKSTROM, M.D.PETER S. HEEGER, M.D., JAY T. BACKSTROM, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-1-143_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Heparin-induced thrombocytopenia, with or without arterial thrombi, has been described as occurring with full-dose intravenous heparin treatment, as well as low-dose subcutaneous treatment (1, 2). We report a case of heparin-induced thrombocytopenia from heparin flushes (< 500 U/d).A 73-year-old man was admitted for evaluation of anuric renal failure. A diagnosis of antiglomerular basement membrane disease was eventually made by renal biopsy. During the evaluation the patient became thrombocytopenic, with the platelet count decreasing from 541000 to 50 000/mm3over 8 to 10 days. He had no evidence of sepsis, disseminated intravascular coagulation, or thrombotic thrombocytopenic purpura...References1. BABCOCKDUMPERSCHARFMAN RCW. Heparin-induced immune thrombocytopenia. N Engl J Med. 1976;295:237-41. CrossrefMedlineGoogle Scholar2. HRUSHESKY W. Thrombocytopenia induced by low-dose subcutaneous heparin. Lancet. 1977;2:1286. CrossrefMedlineGoogle Scholar3. KELTONSHERIDANBRAINPOWERSTURPIECARTER JDHPAC. Clinical usefulness of testing for a heparin-dependent platelet-aggregating factor in patients with suspected heparin-associated thrombocytopenia. J Lab Clin Med. 1984;103:606-12. MedlineGoogle Scholar4. CINESKAYWINBINATOMASKISCHREIGER DPMAA. Heparin-associated thrombocytopenia. N Engl J Med. 1980;303:788-95. CrossrefMedlineGoogle Scholar5. KINGKELTON DJ. Heparin-associated thrombocytopenia. Ann Intern Med. 1984;100:535-40. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Temple University Hospital Philadelphia, PA 19140 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug-induced cutaneous vasculitis and anticoagulant-related cutaneous adverse reactions: insights in pathogenesis, clinical presentation, and treatmentBleeding, Heparin-induced thrombocytopenia, and Other adverse reactionsHeparin-Induced ThrombocytopeniaChallenges of cardiac inflammation imaging with F-18 FDG positron emission tomographyComparison of heparinized saline and 0.9% sodium chloride for maintaining peripheral intravenous catheter patency in dogsGuidelines for Use of Anticoagulation in PregnancyHeparin-Induced ThrombocytopeniaWhy Is the Platelet Count Low: Should I Be Concerned About Heparin-Induced Thrombocytopenia?ASHP therapeutic position statement on the institutional use of 0.9% sodium chloride injection to maintain patency of peripheral indwelling intermittent infusion devicesHeparinised Saline versus Normal Saline in Maintaining Patency of Arterial and Central Venous CathetersDoes Low-Dose Heparin Maintain Central Venous Access Device Patency?Radial Artery Cannulation: A Comprehensive Review of Recent Anatomic and Physiologic InvestigationsIntraoperative Thrombosis From a Heparin-Containing Irrigation Solution in a Patient With Heparin-Induced ThrombocytopeniaTrombocitopenia inducida por heparinaFrequency of Heparin-Induced ThrombocytopeniaMolecular Immunopathogenesis of Heparin-­Induced?ThrombocytopeniaHeparin-Induced ThrombocytopeniaMinimizing the incidence of heparin-induced thrombocytopenia: to heparinize or not to heparinize vascular access?Thrombocytopenia Following Heparin FlushA Comparison of the Efficacy of Heparinized and Nonheparinized Solutions for Maintenance of Perioperative Radial Arterial Catheter Patency and Subsequent OcclusionHeparin-induced thrombocytopenia in the pediatric intensive care unit populationDiagnosis and management of heparin-induced thrombocytopeniaHeparina frente a cloruro sódico 0,9% para mantener permeables los catéteres venosos centrales. Una revisión sistemáticaNatural Saline-Flush Is Sufficient to Maintain Patency of Immobilized-Urokinase Double-Lumen Catheter Used to Provide Temporary Blood Access for HemodialysisCentral venous catheter occlusion and thrombosisAssociation of anti-heparin platelet factor 4 antibody levels and thrombosis in pediatric intensive care patients without thrombocytopeniaHeparin-induced thrombocytopenia: Molecular pathogenesisHeparin-induced thrombocytopeniaHeparin-induced thrombocytopenia (HIT) due to heparin flushes: a report of three casesThe role of heparin-associated antiplatelet antibodies in the outcome of arterial reconstructionHeparin-Induced ThrombocytopeniaHeparin-Induced ThrombocytopeniaNormal saline versus heparin flush for maintaining central venous catheter patency during apheresis collection of peripheral blood stem cells (PBSC)Prevalence of Heparin-Associated Antibodies Without Thrombosis in Patients Undergoing Cardiopulmonary Bypass SurgeryGuideline for Prevention of Intravascular-Device–Related InfectionsGuideline for Prevention of Intravascular-Device-Related InfectionsHeparin-induced thrombocytopeniaAcute pulmonary embolismPeripheral Intravenous Line Survival and Phlebitis Prevention in Patients Receiving Intravenous Antibiotics: Heparin/Hydrocortisone versus In-Line FiltersLow molecular weight heparin for hickman catheter-induced thrombosis in thrombocytopenic patients undergoing bone marrow transplantationHeparin: Mechanism of Action, Pharmacokinetics, Dosing Considerations, Monitoring, Efficacy, and SafetyHeparin-induced thrombocytopeniaSaline versus Heparin in Intermittent Infuser Patency MaintenanceDrug-Induced Blood DisordersIs Heparin Really Necessary in the Lock and, If So, How Much?Drug-induced Immune ThrombocytopeniaHeparin-induced thrombocytopenia.Heparin-induced thrombocytopeniaCase Report: The Heparin Flush Syndrome: A Cause of Iatrogenic HemorrhageDrugs affecting blood coagulation and hemostasis 1 July 1986Volume 105, Issue 1Page: 143-143KeywordsDisseminated intravascular coagulationHeparinHeparin-induced thrombocytopeniaPlateletsRenal diseasesRenal failureResearch laboratoriesSepsisSerotoninThrombotic thrombocytopenic purpura Issue Published: 1 July 1986 PDF DownloadLoading ...