AORTIC SURGERY IN MARFAN'S SYNDROME. HEMODYNAMIC AND HISTOLOGIC RESPONSE
Authors: T KILLIP, N D HOLMQUIST
Journal: Annals of Internal Medicine (1961)

Article1 March 1961AORTIC SURGERY IN MARFAN'S SYNDROME. HEMODYNAMIC AND HISTOLOGIC RESPONSETHOMAS KILLIP III, M.D., NELSON D. HOLMQUIST, M.D.THOMAS KILLIP III, M.D.Search for more papers by this author, NELSON D. HOLMQUIST, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-3-431 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAneurysmal dilatation of the ascending aorta and aortic sinuses with cystic degeneration in the media are well recognized manifestations of Marfan's syndrome.1The relentless progression of the aortic insufficiency which accompanies and, indeed, aggravates the medial change, and the frequent occurrence of acute aortic dissection have stimulated several surgical attempts at correction. Insertion of a prosthetic (Hufnagel) valve, ligation of the aortic annulus, partial excision of the aneurysm, and wrapping of the aorta with plastic, have been reported.1-3Despite these surgical attempts, there has been little histologic information about the response of the aorta burdened with medial cystic necrosis to...Bibliography1. McKusick VA: The Marfan syndrome, in Heritable disorders of connective tissue. 2nd Ed. The C. V. Mosby Co., St. Louis, 1960. Google Scholar2. ConklinGrismerAalpoel WSJTJA: Hufnagel valve surgery for aortic insufficiency. J. Thor. Surg. 36: 238, 1958. CrossrefMedlineGoogle Scholar3. DimondLarsenJohnsonKittle EGWEWBCF: Post-traumatic aortic insufficiency occurring in Marfan's syndrome with attempted repair with a plastic valve. New Engl. J. Med. 256: 8, 1957. CrossrefMedlineGoogle Scholar4. Hemodynamic methods—heart and lungs, Vol. 7, 1958. The Year Book Publishers, Inc., Chicago. Google Scholar5. 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CrossrefMedlineGoogle Scholar24. LiebowHarrisonHales AAWMR: Experimental pulmonic stenosis. J. Tech. Methods 31: 1, 1950. Google Scholar25. Ibid., reference 1, case B. J. P., p. 100. Google Scholar26. AndersonPratt-Thomas MHR: Marfan's syndrome. Amer. Heart J. 46: 911, 1953. CrossrefMedlineGoogle Scholar27. TungLiebow HLAA: Marfan's syndrome. Observations at necropsy: with special reference to medionecrosis of the great vessels. Lab. Invest. 1: 382, 1952. MedlineGoogle Scholar28. Editorial: Marfan's syndrome. New Engl. J. Med. 256: 38, 1957. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 22, 1960.From the Departments of Medicine and Pathology, The New York Hospital-Cornell Medical Center, New York, N. Y.†Assistant Professor of Medicine, Cornell University Medical College; Assistant Attending Physician, The New York Hospital; Markle Scholar in Medical Science.‡Now Assistant Professor of Pathology, Louisiana State University School of Medicine, New Orleans, La.; formerly Instructor in Pathology, Cornell University Medical College.Requests for reprints should be addressed to Thomas Killip, III, M.D., The New York Hospital-Cornell Medical Center, 525 E. 68th Street, New York, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySurgical Treatment of Aneurysms of the Ascending Aorta in the Marfan SyndromeSurgical experience in patients with Marfan's syndrome, ascending aortic aneurysm and aortic regurgitationMarfan's syndrome: A reviewMarfan's syndrome with aneurysm of ascending aorta and aortic regurgitationMultiple aortic aneurysms (thoracic and abdominal) in twins with Marfan's syndrome: Fatal rupture during pregnancyHereditary disorders of connective tissueFamily studies of the Marfan syndromeRuptured aortic cusp associated with an heritable disorder of connective tissueAORTIC DISEASE IN ANKYLOSING SPONDYLITISAUTOIMMUNE RESPONSE IN MYASTHENIA GRAVISMedical genetics 1961 1 March 1961Volume 54, Issue 3Page: 431-442KeywordsAneurysmsAortaHemodynamicsHospital medicineLigation assayMarfan syndromeNecrosisSurgery Issue Published: 1 March 1961 PDF downloadLoading ...