PENICILLIN THERAPY ALONE IN NEUROSYPHILIS: AN ANALYSIS OF CLINICAL RESULTS
Authors: George D. Gammon, John H. Stokes, Howard P. Steiger, Willard H. Steele, Herman Beerman, Norman R. Ingraham, Paul Gyorgy, Elizabeth Rose, John W. Lentz, Abraham Ornsteen, Donald Scott
Journal: Annals of Internal Medicine (1946)

Article1 September 1946PENICILLIN THERAPY ALONE IN NEUROSYPHILIS: AN ANALYSIS OF CLINICAL RESULTSGEORGE D. GAMMON, M.D., F.A.C.P., JOHN H. STOKES, M.D., HOWARD P. STEIGER, WILLARD H. STEELE, M.D., HERMAN BEERMAN, M.D., NORMAN R. INGRAHAM JR., M.D., PAUL GYORGY, M.D., ELIZABETH ROSE, M.D., JOHN W. LENTZ, M.D., ABRAHAM ORNSTEEN, M.D., F.A.C.P., DONALD SCOTT, M.D.GEORGE D. GAMMON, M.D., F.A.C.P.Search for more papers by this author, JOHN H. STOKES, M.D.Search for more papers by this author, HOWARD P. STEIGERSearch for more papers by this author, WILLARD H. STEELE, M.D.Search for more papers by this author, HERMAN BEERMAN, M.D.Search for more papers by this author, NORMAN R. INGRAHAM JR., M.D.Search for more papers by this author, PAUL GYORGY, M.D.Search for more papers by this author, ELIZABETH ROSE, M.D.Search for more papers by this author, JOHN W. LENTZ, M.D.Search for more papers by this author, ABRAHAM ORNSTEEN, M.D., F.A.C.P.Search for more papers by this author, DONALD SCOTT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-3-412 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhen we began the treatment of neurosyphilis with penicillin in November 1943, we determined to use penicillin alone without fever or arsenic or any other therapy which could influence the course of the disease. This seemed the obvious way to find out what the drug could accomplish, and we have followed this plan with a few exceptions which are noted. In substituting a new régime for the older routines of arsenicals and fever, we felt an urgent obligation to keep a close check on clinical effects as well as the results of blood and spinal fluid reactions. Furthermore, by carefully...Bibliography1. STOKESSTEIGERGAMMONSTEELEBEERMANINGRAHAMGYORGYROSELENTZSTEINSTANNARD JHHPGDWHHNRPEKJWVME: Penicillin alone in neurosyphilis, Jr. Am. Med. Assoc., 1946, cxxxi, 1-7. Google Scholar GAMMONSTOKESLENTZSTEELEROSESCOTTSCOTTORNSTEEN GDJHJWWHEKJDMAPrevious reports of this work have been made as follows: : Immediate and early effects of penicillin on syphilis of the central nervous system, Trans. Am. Neurol. Assoc., 1944, 65-69. Google Scholar GAMMONSTOKESBEERMANINGRAHAMLENTZMORGANSTEELEROSE GDJHHNRJWHGWEK, with the technical assistance of VERNA MAYER: Penicillin in neurosyphilis: effect on blood and spinal fluid, Jr. Am. Med. Assoc., 1945, cxxviii, 653-654. CrossrefGoogle Scholar STOKESGAMMONBEERMANINGRAHAMLENTZMORGANSTEELEROSEGYORGY JHGDHNRJWHWEKP: Penicillin in late syphilis, Am. Jr. Syph., Gon., and Ven. Dis., 1945, xxix, 313-333. Google Scholar STOKESSTERNBERGSCHWARTZMAHONEYMOOREWOOD JHTWHJFJEWB: The action of penicillin in late syphilis, Jr. Am. Med. Assoc., 1944, cxxvi, 73-79. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE D. GAMMON, M.D., F.A.C.P.; JOHN H. STOKES, M.D.; HOWARD P. STEIGER; WILLARD H. STEELE, M.D.; HERMAN BEERMAN, M.D.; NORMAN R. INGRAHAMJR., M.D.; PAUL GYORGY, M.D.; ELIZABETH ROSE, M.D.; JOHN W. LENTZ, M.D.; ABRAHAM ORNSTEEN, M.D., F.A.C.P.; DONALD SCOTT, M.D.Affiliations: Philadelphia, Pennsylvania*Read at the Twenty-Seventh Annual Session, American College of Physicians, Philadelphia, May 13-17, 1946.From the Institute for the Study of Venereal Disease, University of Pennsylvania and United States Public Health Service coöperating, and the Department of Neurology and the Penicillin-Syphilis Panel of the University Hospital. The Institute, the Departments of Neurology, Ophthalmology, Dermatology and Syphilology, and Pediatrics, and the Division of Venereal Disease Control, Philadelphia City Department of Public Health, and the Philadelphia General, Pennsylvania, and Children's Hospitals are represented in the authorship.The work described in this paper was done under a contract recommended by the Committee on Medical Research, between the Office of Scientific Research and Development and the University of Pennsylvania.The investigation was assisted by contributions from the Gar Wood Research Fund and the Kirby-McCarthy Fund. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie psychischen Störungen bei Infektions- und TropenkrankheitenRecent Developments in the Treatment of SyphilisSyphilisNeurosyphilis and the Latest Methods of TreatmentBarreira hemoencefálica 1 September 1946Volume 25, Issue 3Page: 412-432KeywordsFeversHyperthermiaMedical servicesNeurologyOphthalmologyPediatricsPenicillinPrevention, policy, and public healthResearch fundingSexually transmitted diseases ePublished: 1 December 2008 Issue Published: 1 September 1946 PDF downloadLoading ...