tbuckley/cabot-search huggingface dataset:
Gift of the Gods
Authors: Frances L. Drew
Journal: JAMA (1983)

Hollywood never devised an image as grotesque as nature achieved in Dorothy, her name the ultimate irony—Doro-thea, gift of the gods. Her pituitary gland had run amok before adolescence, leaving her a giant nearly 7 ft tall. It had continued to pump after her long bones were fused, spurring the softer bones in her jaw, her hands, and her feet to even greater size. Obesity added insult to her height. Her face with its jutting lower jaw oozed pus from its acne; her dark-brown hair sagged under its weight of oil. Only her eyes were beautiful: large brown-black velvet circles lost in the distortions of her face. And her mind was as keen as a winter's day. I met her when she came to the Student Health Service as a new patient. The folder contained only her name and the school in which she was enrolled as a graduate student.
Is full colonoscopic examination necessary in young patients with fresh bleeding per rectum?
Authors: A. Khalid, S. Majid, M. Salih, F. Hashmat, W. Jafri
Journal: Endoscopy (2011)

Background and study aims: Guidelines and practices differ regarding evaluation of young patients with fresh bleeding per rectum (FBPR). The aim of this study was to determine the frequency and site of endoscopic lesions in young patients with FBPR, and to thereby determine whether full colonoscopic examination is necessary in these patients.
The self-sustained sequence replication amplification system-move over, PCR Gingeras TR, Prodanovich P, Latimer T, Guatelli JC, Richman DD, Barringer KJ. Detection of human immunodeficiency virus type I in AIDS patients using amplification-mediated hybridization analyses: Reproducibility and quantitative limitations. J Infect Dis 1991;164:1066–1074
Authors: K Lown
Journal: Hepatology (1993)
A piece of my mind. First encounter
Authors: D. J. McCullough
Journal: JAMA (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ultrasound-aided microbubbles facilitate the delivery of drugs to the inner ear via the round window membrane
Authors: Cheng-Ping Shih, Hsin-Chien Chen, Hang-Kang Chen, Min-Chang Chiang, Huey-Kang Sytwu, Yi-Chun Lin, Shiue-Li Li, Yu-Fan Shih, Ai-Ho Liao, Chih-Hung Wang
Journal: Journal of Controlled Release (2013)
Modification of sinus node function by epicardial laser irradiation in dogs.
Authors: L Littmann, R H Svenson, J J Gallagher, S Bharati, M Lev, K D Linder, G P Tatsis, C Nichelson
Journal: Circulation (1990)

This study tested the feasibility of neodymium:YAG laser photocoagulation of selected sinus node areas to depress sinus rate responsiveness. In 14 open-chest dogs, origin of the sinus impulse (O point) was electrically mapped from the epicardium before and during isoproterenol infusion. Epicardial laser photocoagulation was applied to the O point observed during isoproterenol infusion and stepwise to remapped new O points until a 30 +/- 5% decrease in heart rate occurred. Long-term effects were assessed by Holter monitoring and electropharmacologic testing preoperatively and up to 10 weeks or 6 months. Mean (+/- SEM) percent decreases were observed at 10 weeks in the following parameters: average 24-hour heart rate, 17.4 +/- 5.0%; maximum heart rate on Holter, 30.5 +/- 3.5%; heart rate during pharmacologic autonomic blockade, 32.7 +/- 3.5%; and maximum heart rate on isoproterenol, 23.1 +/- 4.6% (all p less than 0.01). Curves with pacemaker recovery time plotted against control cycle length remained unchanged. Holter monitoring did not show excessive bradycardic episodes even after administration of propranolol. In three control dogs (sham operation), sinus node function remained unchanged. Histologic study of the irradiated area showed replacement by inflammatory cells, fibrosis, and cartilage formation with surrounding normal cells and occasional cells resembling pacemaker-like cells at the caudal end of the sinoatrial node. This study suggests that 1) map-guided graded laser photocoagulation of sinus node regions showing earliest activation during catecholamine stimulation successfully limits maximum heart rates without causing significant bradycardia, 2) the effects are long lasting, and 3) the remaining pacemaker behaves like the sinus node. Laser modification of sinus node function could become a form of nonpharmacologic heart rate control in patients with coronary artery disease undergoing surgery and in the syndrome of inappropriate sinus tachycardia.
Polypoid lesions following surgical correction of bladder exstrophy
Authors: E. Kaufman, M. Fried
Journal: Endoscopy (2009)

A 28-year-old man with chronic diarrhea was referred for colonoscopy. He had been diagnosed as having urinary bladder exstrophy at birth, which was surgically repaired with bilateral ureterosigmoidostomy to divert the flow of urine. He had no fecal or urinary incontinence. Both abdominal and testicular ultrasound scans were normal.
BONE MARROW TRANSFUSIONS
Authors: Maurice Morrison
Journal: JAMA (1941)

<h3>To the Editor:—</h3> In reply to many inquiries concerning the article "Bone Marrow Transfusion," published in the November 16 issue ofThe Journal, it would not be amiss to point out that a new method of therapy was presented. Since publication, more than sixty bone marrow transfusions have been done in cases of leukemia, myelogenous and lymphatic, and aplastic anemias. Since the series of cases is so small, conclusions cannot be drawn. However, the results are encouraging in that one noted a definite trend toward improved maturation and delivery of the bone marrow cells with the production of clinical and hematologic remissions. For this reason we are continuing bone marrow transfusions in the treatment of the deficiency blood dyscrasias. The present status of the case reported (the first of our series and not a selected one) is as follows: The patient was seen again on June 10, 1940. He had
Bronchodilator Effects on Gastric Acid Secretion
Authors: Larry J. Foster
Journal: JAMA (1979)

Nine patients with chronic obstructive pulmonary disease were given oral aminophylline, intravenous aminophylline, and various inhaled and oral adrenergic bronchodilators to determine the effect of these agents on gastric acid secretion and gastrin release. Inhaled epinephrine hydrochloride resulted in an increase in basal acid output of borderline significance (.05 less than P less than .10). Oral aminophylline caused a significant increase in basal acid output from 2.43 to 4.06 mEq (P less than .05). Intravenous aminophylline also caused a significant increase in basal acid output from 0.66 to 2.19 mEq (P less than .01). There were no statistically significant changes in serum gastrin levels after administration of any of the bronchodilators. Aminophylline should be used with caution, if at all, in patients with peptic ulcer disease. In these patients, a beta agonist should be used for initial therapy. If the addition of aminophylline is necessary, antacids should be given.
Prior chemotherapy and allograft CD34+ dose impact donor engraftment following nonmyeloablative allogeneic stem cell transplantation in patients with solid tumors
Authors: Cristian Carvallo, Nancy Geller, Roger Kurlander, Ramaprasad Srinivasan, Othon Mena, Takehito Igarashi, Linda M. Griffith, W. Marston Linehan, Richard W. Childs
Journal: Blood (2003)
Utility of the Fluorescent Antinuclear Antibody Test in a Single Patient
Authors: Bruce Richardson, Wallace V. Epstein
Journal: Annals of Internal Medicine (1981)

The literature on the fluorescent antinuclear antibody (FANA) test, commonly used in diagnosing systemic lupus erythematosus, was analyzed. The specificity of the test reported in early descriptive studies is much greater than the value obtained when the test is used in clinical practice. The probability of systemic lupus erythematosus in a specific patient was determined when different numbers of the classification criteria developed by the American Rheumatism Association are present. The predictive value of a positive or negative FANA test result was calculated using different pretest probabilities based on clinical criteria. The marginal benefit of the FANA test was determined as minimal at points of very large and very small pretest probability of systemic lupus erythematosus, and as maximal when five clinical criteria are present.
The effect of changes in hepatocyte membrane potential on immediate-early proto-oncogene expression following partial hepatectomy in rats
Authors: G Y Minuk, B T Kren, R Xu, X Zhang, F Burczynski, N P Mulrooney, G Fan, Y Gong, C J Steer
Journal: Hepatology (1997)

The stimulus responsible for inducing hepatocytes to enter the cell cycle following partial hepatectomy (PHx) remains to be identified. One suggested candidate is the change in hepatocyte membrane potential (PD) that occurs immediately following PHx. To test this possibility, we monitored changes in hepatocyte PD and immediate-early proto-oncogene expression in rats pretreated with saline or gamma aminobutyric acid (GABA), an amino-acid neurotransmitter that hyperpolarizes isolated hepatocytes. Intraperitoneal injections of saline or GABA (500 μg/g body weight) were administered to adult, male Sprague-Dawley rats 1 hour prior to 70% PHx. Rats were sacrificed and the livers excised at various times until 180 minutes post-PHx for messenger RNA (mRNA) and protein analyses. In additional groups of saline- and GABA-treated rats, PD changes were recorded continuously from −260 to 180 minutes post-PHx. Serum GABA concentrations were determined by ion-exchange chromatography with orthopthaldehyde fluorescence detection. Hepatocyte PD's were recorded in situ by intracellular microelectrodes with an Axoprobe-1A amplifier. Steady-state levels of c- fos , c- jun , jun -B, and c- myc transcripts and proteins were documented by Northern blots of poly(A)-enriched RNA derived from resected livers and Western blots of total nuclear protein, respectively. Serum GABA concentrations remained unchanged in saline-treated controls but increased 10- to 20-fold above baseline values in GABA-treated rats. In saline-treated controls, hepatocyte depolarization occurred immediately and was maintained throughout the 180 minutes post-PHx period (PD pre-PHx, −36.8 ± 5.1; 15 minutes post-PHx, −27.5 ± 5.7; and 180 minutes post-PHx, −28.3 ± 4.4 mV, mean ± SD); whereas in GABA-treated rats, hepatocyte PD remained unchanged (-37.0 ± 1.1; −36.4 ± 3.1 and −39.2 ± 2.7 mV, respectively). Despite abrogation of hepatocyte PD changes, proto-oncogene mRNA and protein levels in saline- and GABA-treated rats were either similar or, in the case of c- fos and c- jun , increased five- to sevenfold in GABA-treated rats. The results of this study indicate the following: 1) hepatocytes depolarize immediately post-PHx and remain depolarized throughout the priming phase of the cell cycle; 2) elevated serum GABA concentrations prevent PHx-induced hepatocyte depolarization; and 3) depolarization is not the stimulus responsible for priming hepatocytes into replicative competence.
IgG4-Related Neuropathy
Authors: Ken Ohyama, Haruki Koike, Masahiro Iijima, Rina Hashimoto, Minoru Tomita, Yuichi Kawagashira, Akira Satou, Shigeo Nakamura, Gen Sobue
Journal: JAMA Neurology (2013)

Importance:The newly recognized entity IgG4related disease (IgG4-RD) is characterized by an elevated IgG4 serum concentration and tissue infiltration by IgG4-positive plasma cells.We describe, for the first time, the clinical features and nerve biopsy findings of a patient with IgG4-RD who presented with neuropathy in the extremities.Observations: A 55-year-old man had histopathologically defined IgG4-RD that manifested as sensorymotor neuropathy.The neuropathic features were multiple mononeuropathies with electrophysiological findings suggestive of axonal neuropathy.Marked thickening with abundant collagen fibers and infiltration of IgG4-positive plasma cells were observed in the epineurium of the biopsied sural nerve.A moderate degree of myelinated fiber loss without evidence of segmental demyelination was present, whereas necrotizing vasculitis was not found.Oral prednisolone therapy ameliorated the neuropathic symptoms.Conclusions and Relevance: This case of IgG4-RD presented as sensory-motor neuropathy with pain and sclerosis of the skin in the extremities.The differential diagnosis of neuropathy should include IgG4-RD.
TOTAL EXCHANGEABLE POTASSIUM AND CHLORIDE AND TOTAL BODY WATER IN HEALTHY MEN OF VARYING FAT CONTENT
Authors: E. A. Boling, W. L. Taylor, C. Entenman, A. R. Behnke
Journal: Journal of Clinical Investigation (1962)

During the past few years various attempts have been made to develop an improved standard of reference for comparison of those parameters of body composition which refer largely to lean body mass.Weir measured carcass chloride in dogs and found poor correlation between carcass chlo- ride and body weight (1).He found, however, better correlation between carcass chloride and fat- free carcass weight (2).Corsa and co-workers (3) pointed out the theoretical desirability of re- lating total exchangeable potassium (Ke) to lean body mass or to a parameter closely related to lean body mass.Cheek and West (4) found that Ke, carcass potassium, Cle, and carcass chloride in rats were closely related to both fat-free carcass weight and to total body water (TBW).Mul- downey, Crooks, and Bluhm (5, 6) measured Ke, Cle, antipyrine space, plasma volume, and red cell mass in adult human beings and compared all these except antipyrine space with lean body mass, derived from antipyrine space, and with creatinine excretion.They found that the correlation of each parameter with the derived lean body mass was significantly better than its correlation with body weight.McMurrey and co-workers (7) meas- ured total exchangeable chloride, potassium, and sodium (Cle, Ke, and Nae), red cell mass, plasma volume, and TBW in a group of ten healthy men and ten healthy women.Their data show much better correlation of these parameters with TBW than with body weight.Recently, O'Meara, Birkenfeld, Gotch, and Edel- man (8) have found that the mixing of adminis- tered K42 is prolonged in subjects who have edema.It was concluded by these authors that equilibration times should be extended to 40 hours when measuring Ke in sick patients.Because of the short half-life of K42, this makes the measurement
A novel evidence-based detection of undiagnosed spondyloarthritis in patients presenting with acute anterior uveitis: the DUET (Dublin Uveitis Evaluation Tool)
Authors: Muhammad Haroon, Michael O'Rourke, Pathma Ramasamy, Conor C Murphy, Oliver FitzGerald
Journal: Annals of the Rheumatic Diseases (2014)

To date, there are no formal guidelines or referral pathways for acute anterior uveitis (AAU) patients developed or endorsed by any international or national societies. The objective of our study was to develop and validate an assessment algorithm for referral from ophthalmologists of appropriate AAU patients to rheumatology that will aid the early diagnosis of the spondyloarthropathy (SpA).All consecutive patients attending the emergency department of local ophthalmology hospital with AAU, but who did not have a known diagnosis of SpA, were eligible to participate in this study. Patients with any other known cause of AAU were excluded. Two independent cohorts were enrolled. Test algorithm and Dublin Uveitis Evaluation Tool (DUET) algorithm (revised form of test algorithm) were used in these cohorts to identify patients as SpA suspects and non-SpA controls, respectively.STUDY PHASE-1. ALGORITHM DEVELOPMENT COHORT (n=101): After rheumatologic evaluation of the entire cohort, 41.6% (n=42) had undiagnosed SpA. Our test algorithm was noted to have: sensitivity 100% and specificity 53.5%. Further regression analysis resulted in the development of the DUET algorithm which made the following improvements: sensitivity 95%, specificity 98%, positive likelihood ratio (LR) 56.19, and negative LR 0.04. STUDY PHASE-2. DUET ALGORITHM VALIDATION COHORT (n=72): After rheumatologic evaluation of the cohort, 40% (n=29) were diagnosed with SpA, with the following performance of DUET algorithm-sensitivity 96%, specificity 97%, positive LR 41.5 and negative LR 0.03.Approximately 40% of patients presenting with idiopathic AAU have undiagnosed SpA. A simple to apply algorithm is described with excellent sensitivity and specificity.
CASES OF CONGENITAL MALFORMATION OF THE RECTUM AND VAGINA
Authors: G. Mallett
Journal: BMJ (1853)

OPERATION SUCCESSFULLY PERFORMED.Mary I-n, aged two years and a half, apparently a healthy and well-formed girl, was brought to me, her parents being desirous to ascertain if anything could be done to relieve a disgusting defect, which had existed from birth.They stated that there was no anus, and that she had passed all her fices through the vagina.An examination disclosed neither aperture nor depression where the anus should have been.Upon making further inquiry, I found that every second or third day she became restless and uneasy, and that she en- deavoured to make them understand that she suffered pain
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy
Authors: Sandeep Uppal, Christine P Diggle, Ian M Carr, Colin W G Fishwick, Mushtaq Ahmed, Gamal H Ibrahim, Philip S Helliwell, Anna Latos-Bieleńska, Simon E V Phillips, Alexander F Markham, Christopher P Bennett, David T Bonthron
Journal: Nature Genetics (2008)
THE TOCOPHEROLS (VITAMIN E) IN THE TREATMENT OF PRIMARY FIBROSITIS
Authors: CHARLES LEROY STEINBERG
Journal: Annals of Internal Medicine (1943)

Article1 July 1943THE TOCOPHEROLS (VITAMIN E) IN THE TREATMENT OF PRIMARY FIBROSITISCHARLES LEROY STEINBERG, M.D.CHARLES LEROY STEINBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-1-136 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe therapy of primary fibrositis has been most unsatisfactory, and there is no unanimity of opinion regarding it. Previous communications have called attention to the similarity in the pathologic lesions between so-called nutritional muscular dystrophy and primary fibrositis. Mackenzie and McCollum have shown that the development of nutritional muscular dystrophy is accompanied by an increase in urinary creatine excretion, and improvement by decrease in urinary creatine.Creatine excretion studies were done on 15 cases of primary fibrositis by the Folin microchemical method. After tocopherol therapy these studies were repeated on 13 cases. The creatine excretion was increased in all cases... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySymptomatologie und Therapie der E-AvitaminoseTHE USE OF TOCOPHEROLS IN THE TREATMENT OF PEYRONIE'S DISEASETOCOPHEROL THERAPY OF URETHRAL STRICTURES?A PRELIMINARY REPORTTHE USE OF TOCOPHEROLS IN THE TREATMENT OF PEYRONIE'S DISEASETOCOPHEROL THERAPY OF URETHRAL STRICTURES-A PRELIMINARY REPORTRHEUMATISM AND ARTHRITIS REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (Ninth Rheumatism Review)* Part IIPHILIP S. HENCH, M.D., F.A.C.P., WALTER BAUER, M.D., F.A.C.P., EDWARD W. BOLAND, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., RICHARD H. FREYBERG, M.D., F.A.C.P., WALLACE GRAHAM, M.D., F.R.C.P.(C), W. PAUL HOLBROOK, M.D., F.A.C.P., L. MAXWELL LOCKIE, M.D., F.A.C.P., CURRIER MCEWEN, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., ROBERT M. STECHER, M.D., F.A.C.P.The Use of Vitamins in the Treatment of Chronic ArthritisA New Method of Treatment of Dupuytren's Contracture, A Form of Fibrositis 1 July 1943Volume 19, Issue 1Page: 136-139KeywordsCreatineExcretionFibromyalgiaLesionsMuscular dystrophiesNutritionVitamin E ePublished: 1 December 2008 Issue Published: 1 July 1943 PDF downloadLoading ...
Let the Punishment Fit the Crime: Sensible Consent in the Management of Human Subjects Research and Standard-of-Care Interventions
Authors: Ross E. McKinney
Journal: The American Journal of Bioethics (2013)

Click to increase image sizeClick to decrease image size Acknowledgments The author appreciates the critique and suggestions regarding this commentary by Gopal Sreenivasan, PhD. Dr. McKinney is funded in part by the NIH Healthcare Systems Research Collaboratory (Robert Califf, MD, Principal Investigator) (5 U54 AT007748 02).
Usefulness of Magnifying Endoscopy in the Diagnosis of Early Gastric Cancer
Authors: Y. Otsuka, Y. Niwa, N. Ohmiya, N. Ando, A. Ohashi, Y. Hirooka, H. Goto
Journal: Endoscopy (2004)

We investigated the characteristic findings of early gastric cancer revealed by magnifying endoscopy, and clarified their relationship with histopathological features.A total of 74 patients with early gastric cancer underwent magnifying endoscopy ( x 80) between March 2000 and December 2001. The endoscopic findings demonstrated 11 elevated-type carcinomas and 63 depressed-type, and histological examination showed 56 differentiated carcinomas and 18 undifferentiated carcinomas. The histopathological results were compared with findings from magnifying endoscopy regarding minute surface structure and microvessels.We were able to roughly classify the minute surface structure of early gastric cancer as shown by magnifying endoscopy into three patterns, as follows: (i). a small regular pattern of sulci and ridges; (ii). an irregular pattern of sulci and ridges; and (iii). a lack of visible structure. Abnormal microvessels observed in cancerous lesions were classified according to two patterns: irregular minute vessels and variation of vessel caliber. The small regular pattern of sulci and ridges was significantly more frequently observed in differentiated carcinoma (30/56, 53.6 %) than in undifferentiated carcinoma (2/18, 11.1 %). Lack of visible structure and irregular minute vessels were significantly more frequently observed in undifferentiated carcinoma (44.4 % and 77.7 %) than in differentiated carcinomas (5.4 % and 51.8 %).The minute surface structure and microvessels observed by magnifying endoscopy were related to histopathological findings. Magnifying endoscopy is valuable for predicting the histological nature in the diagnosis of early gastric cancer.
Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis
Authors: Yi-Ching Lee, Ho-Chang Kuo, Jeng-Sheng Chang, Luan-Yin Chang, Li-Min Huang, Ming-Ren Chen, Chi-Di Liang, Hsin Chi, Fu-Yuan Huang, Meng-Luen Lee, Yhu-Chering Huang, Betau Hwang, Nan-Chang Chiu, Kao-Pin Hwang, Pi-Chang Lee, Li-Ching Chang, Yi-Min Liu, Ying-Ju Chen, Chien-Hsiun Chen, Yuan-Tsong Chen, Fuu-Jen Tsai, Jer-Yuarn Wu
Journal: Nature Genetics (2012)