tbuckley/cabot-search huggingface dataset:
Essential fatty acid deficiency ameliorates acute renal dysfunction in the rat after the administration of the aminonucleoside of puromycin.
Authors: K P Harris, J B Lefkowith, S Klahr, G F Schreiner
Journal: Journal of Clinical Investigation (1990)

The administration of the aminonucleoside of puromycin (PAN) to rats causes the nephrotic syndrome that is associated with an acute decline in renal function, and an interstitial infiltrate. We examined whether essential fatty acid deficiency (EFAD), which inhibits macrophage infiltration in glomerulonephritis, affects PAN-induced renal dysfunction. Both control and EFAD rats developed proteinuria that resolved over 28 d. After PAN administration, there was a prominent infiltration of macrophages in rats fed a normal diet. The infiltrate was prevented by the EFAD diet. The absence of a macrophage interstitial infiltrate was associated with a significantly higher Cin in the EFAD rats than in controls at 7 d (5.21 +/- 1.19 versus 0.39 +/- 0.08, P less than 0.002 ml/min/kg BW). In addition, CPAH fell to less than 10 ml/min/kg BW by day 7 in controls, but remained the same as normal in the EFAD. After administration of PAN to control rats, there was no increase in urinary thromboxane excretion or an increase in glomerular thromboxane production. Furthermore, the effect of EFAD could not be mimicked by the administration of a thromboxane synthase inhibitor. Irradiation-induced leukopenia in rats on a normal diet markedly improved glomerular filtration and renal blood flow in acutely nephrotic rats. EFAD prevents the interstitial cellular infiltrate and the renal ischemia associated with experimental nephrosis. The recruitment of mononuclear cells into the kidney following PAN directly contributes to the decline in renal function.
736 EVIDENCE OF NEUROINFLAMMATION IN PATIENTS WITH CHRONIC HEPATITIS C: A CEREBRAL POSITRON EMISSION TOMOGRAPHY (PET) STUDY
Authors: V.P. Grover, N. Pavese, S.-B. Koh, M. Wylezinska, A. McGuinness, B.K. Saxby, A. Gerhard, D.M. Forton, H.C. Thomas, D.J. Brooks, S.D. Taylor-Robinson
Journal: Journal of Hepatology (2008)
Developmental Arrest Due to Corticosteroid Intoxication in an Infant with Adrenocortical Virilism
Authors: Alexander N. Drescher, Nathan B. Talbot
Journal: New England Journal of Medicine (1957)

THE production of classic Cushing syndrome is a well known side effect of vigorous adrenocortical steroid therapy. Marked retardation of statural growth and skeletal maturation are known to occur in Cushing's disease1 and have been observed in patients receiving large doses of cortisone.2 , 3 The presentation of the following case emphasizes this growth-suppressive action, as illustrated in the total developmental arrest of an infant receiving liberal doses of cortisone, desoxycorticosterone acetate (DCA) and sodium salt for the treatment of adrenocortical virilism.Case ReportC.C. (M.G.H. 939569), a full-term male infant, was delivered after an uncomplicated pregnancy and weighed 3.25 kg. On . . .
Human monocytes can produce tissue-type plasminogen activator.
Authors: P H Hart, G F Vitti, D R Burgess, D K Singleton, J A Hamilton
Journal: The Journal of Experimental Medicine (1989)

Evidence has previously been presented that monocytes and macrophages produce urokinase-type plasminogen activator. We have shown for the first time that human monocytes, when stimulated appropriately in vitro, can produce tissue type-plasminogen activator (t-PA) of 70 kD. Detection of t-PA mRNA was consistent with the biochemical and immunological characterization of t-PA produced by human monocytes.
An enteroglucagon tumour
Authors: S. R. Bloom
Journal: Gut (1972)

A hormone-secreting renal tumour that affected small bowel structure, motility, and function has been described by Gleeson et al (1971).The present studies show that the large amount of glucagon-like immunoreactivity which could be extracted from this tumour had the molecular weight, action on plasma insulin and glucose in vivo, and immunological reactions of the gut hormone enteroglucagon.This is the first enteroglucagonoma to be reported.
Adenine nucleotide depletion and contractile dysfunction in the "stunned" myocardium
Authors: R. Zucchi, U. Limbruno, A. D. Vincenzo, M. Mariani, G. Ronca
Journal: Cardiovascular Research (1990)

The aim of the study was to assess the contribution of adenine nucleotide depletion to postischaemic myocardial dysfunction ("stunned" myocardium).Isolated perfused hearts release purine catabolites even in the absence of ischaemia, and undergo spontaneous reduction of adenine nucleotide pool. A comparison was therefore made between mechanical function, purine release and tissue adenine nucleotides in working rat hearts reperfused after short term ischaemia or subjected to prolonged perfusion (up to 180 min).49 Sprague-Dawley rats of 250-300 g body weight were used. The animals were anaesthetised and the hearts quickly excised and perfused with the working heart technique.Reperfusion after 10 min ischaemia provided a good model of "stunned" myocardium: aortic flow and minute work decreased by 15(SEM 2)% and 20(3)%, no enzyme leakage was observed, and the adenine nucleotide pool decreased by 3.5(0.4) mumols.g-1. During prolonged perfusion no change was observed in any haemodynamic variable until the adenine nucleotide pool was depleted by over 8.5 mumols.g-1. Adenylate energy charge and the phosphocreatine-creatine pool were unchanged in all cases.Depletion of adenine nucleotides does not account for contractile dysfunction in our model of "stunned" myocardium.
A Case of Puerperal Tetanus
Authors: B. Maclean, P. Challen
Journal: BMJ (1941)

Cases of tetanus occurring in the mother following child- birth have been recorded in many parts of the world, but after careful study of the literature at our disposal we are unable to find any reference to such in the British Isles.Obstetrical textbooks discuss the possibility of its arising from imperfectly sterilized catgut used in suturing lacera- tions, and of tetanus neonatorum from infection of the umbilical cord.Because of the above facts we consider the following case should be recorded. References in the LiteratureWe find that post-partum tetanus hAs been described mainly in America, France, China, and Germany.Some interesting points might be cited from various articles.
Complications of Obesity
Authors: GEORGE A. BRAY
Journal: Annals of Internal Medicine (1985)

The major diseases associated with obesity are hypertension, atherosclerosis, and diabetes, as well as certain types of cancer. Less well-known complications include hepatic steatosis, gallbladder disease, pulmonary function impairment, endocrine abnormalities, obstetric complications, trauma to the weight-bearing joints, gout, cutaneous disease, proteinuria, increased hemoglobin concentration, and possibly immunologic impairment. A U- or J-shaped curve illustrates the relation between body mass index and the degree of these various complications. This relationship can be used to provide guidelines for assessing treatment of obesity.
Liver Trauma with Bile Leakage Detected by Hepatobiliary Scintigraphy
Authors: HISAO ITOH, REIKO SHIMONO, KEN HAMAMOTO
Journal: Clinical Nuclear Medicine (1987)

Hepatobiliary scintigraphy is useful in evaluating liver injury and biliary damage, caused by blunt trauma of the liver. A 42-year-old man who was involved in an accident was brought to the emergency room with abdominal pain and dyspnea. Plain chest x-ray film was normal, and computed tomography (CT) revealed the laceration of the liver. Hepatobiliary scintigraphy with Tc-99m-N-pyridoxyl-5-methyltryptophan (PMT) was performed to evaluate the possibility of bile leak seven days after admission. Serial images demonstrated marked retention of radioactivity in the intrahepatic duct and abnormal accumulation at subhepatic location. These findings were though to represent an obstructive change at the level of the left hepatic duct and a subcapsular bile leakage caused by the hepatic laceration.
NHS paid 95m to dismiss managers who were later re-employed
Authors: Z. Kmietowicz
Journal: BMJ (2013)

A fifth of the 10 000 managers made redundant between May 2010 and September 2012 as part of the coalition government’s reorganisation of the NHS were subsequently re-employed, the public spending watchdog has found. 

With average payouts of £43 095 (€50 000; $64 000) each, together these 2200 managers cost the NHS £95m to dismiss.

Redundancy payments were the single most expensive cost of implementing the Health and Social Care Act, accounting for 40% (£435m) of the £1.1bn cost of the changes up to 31 March 2013, the National Audit Office has said in a new report.1 

These costs included £12.2m for redundancy payments to 44 “very senior managers”—an average of around £280 000 per person and ranging from £33 771 to £578 470. Redundancy payments can be reclaimed only if the person rejoins the NHS within fours weeks of leaving.

A key aim of the NHS changes was to reduce management staff and the administration costs of running the NHS in England. However, the government aimed to keep redundancies to a minimum by transferring people working in primary care trusts and strategic health authorities to new posts in the national body NHS England, local clinical commissioning groups, Public Health England, and other agencies. …
Immunolocalization of matrix metalloproteinase 3 (stromelysin) in rheumatoid synovioblasts (B cells): correlation with rheumatoid arthritis.
Authors: Y Okada, N Takeuchi, K Tomita, I Nakanishi, H Nagase
Journal: Annals of the Rheumatic Diseases (1989)

Metalloproteinases produced by connective tissue cells may play a key part in the destruction of joints in rheumatoid arthritis. Matrix metalloproteinase 3 (MMP-3; stromelysin) capable of degrading cartilage proteoglycans and type IX collagen and of activating procollagenase was immunolocalised in hyperplastic synovial lining cells in rheumatoid synovium, but not in the cells of normal synovium. Cells responsible for synthesis of MMP-3 have the phenotype of synovioblasts (B cells) by immunoelectron microscopy, but not of phagocytic synovial macrophages (A cells). Cultured monolayer of rheumatoid synovial cells synthesises MMP-3 only under treatment with macrophage conditioned medium. Immunolocalisation of MMP-3 in rheumatoid synovium and cultured synovial cells was possible when the specimens were treated with a monovalent ionophore, monensin. These results suggest that MMP-3 is synthesised and secreted continuously without storage from hyperplastic synovioblasts stimulated by factor(s) derived from activated macrophages present in the synovium.
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia
Authors: Joni Van der Meulen, Viraj Sanghvi, Konstantinos Mavrakis, Kaat Durinck, Fang Fang, Filip Matthijssens, Pieter Rondou, Monica Rosen, Tim Pieters, Peter Vandenberghe, Eric Delabesse, Tim Lammens, Barbara De Moerloose, Björn Menten, Nadine Van Roy, Bruno Verhasselt, Bruce Poppe, Yves Benoit, Tom Taghon, Ari M. Melnick, Frank Speleman, Hans-Guido Wendel, Pieter Van Vlierberghe
Journal: Blood (2014)
Brazil and the Framework Convention on Tobacco Control: Global Health Diplomacy as Soft Power
Authors: Kelley Lee, Luiz Carlos Chagas, Thomas E. Novotny
Journal: PLoS Medicine (2010)

As part of the PLoS Medicine series on Global Health Diplomacy, Kelley Lee and colleagues provide a case study of Brazil's growing influence in international relations and global health, using as an example that country's role and use of "soft power" in the negotiation of the Framework Convention on Tobacco Control.
Abstract 3224: Targeted non-invasive therapy of prostate cancer using fusogenic liposomes
Authors: Rae Nesbitt, Desmond Pink, Roy Duncan, John Lewis
Journal: Cancer Research (2011)

Abstract Prostate cancer is the most common cancer in Canadian men. Most chemotherapeutic drugs do not preferentially target the tumour and therefore subject the patient's healthy cells to significant toxicity. There is therefore an urgent need for a novel strategy to deliver chemotherapeutic drugs specifically to the tumour. P14 is a fusion associated small transmembrane (FAST) protein which mediates efficient cell-cell interaction. When we incorporate this p14 FAST protein into liposomes we increase the fusion of the liposome to cell membranes. I hypothesize that targeted ablation of prostate cancer may be achieved by delivering chemotherapeutics encapsulated inside fusogenic liposomes targeted to the gastrin releasing peptide receptors. The objectives of the study are to i) validate the fusogenic properties of p14-containg liposomes ii) express and purify p14-bomesin fusion protein, iii) assemble targeted fusogenic lipsoomes iv) and assess the targeted ablation of human prostate cancer in a xenograft model. To validate the fusogenic properties of p14-containing liposomes in our cell lines, we encapsulated fluorescent dextran inside liposomes containing either no p14, mutant p14 (fusogenic incompetent) or an active p14. We incubated the liposomes on human fibrosarcoma cells (HT1080) and measured the uptake of fluorescent dextran using fluorescent microscopy. To construct a fusion protein, we used PCR amplification to fuse bombesin to the C-terminus of the p14 protein. Our analysis demonstrates that the incorporation of the p14 protein significantly increased the fluorescent dextran uptake in the cytoplasm of the HT1080 cells compared to the liposomes that contained no p14 and the mutant p14. Protein purification of the p14-bombesin fusion protein is still in progress. I propose to use these targeted fusogenic liposomes for future studies to evaluate the ability of bombesin-coated fusogenic liposomes to target prostate cells in vitro and deliver a toxic therapeutic payload to prostate tumours in vivo and assess tumour reduction. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3224. doi:10.1158/1538-7445.AM2011-3224
FEBRICULA AND INFLUENZA
Authors: A. I. Simey
Journal: BMJ (1922)

A 28, I9221 FEBRICULA AND INFLUTENZA. I -I I33tions may be raised to the removal of the lower incisor teeth.On the other hand, when affected by only a slight degree of pyorrhoea, the lower incisors may become the source of a virulent infective p gent, independent of the quantity of pus diseharged, in particular as the focus from which a streptococcal infection may arise.Granted this, it may be best to extract these teeth first, and after the oral sepsis has been reduced remove the more deeply rooted teetl.I lhave many times removed a number of teeth at one operation without noting shock -or inflammatory reaction, but rather an immediate relief of the oral sepsis.The cases have, however, been treated like others undergoing major operations, including prelinminary preparations, a general anaes- thetic, disinfection, and extraction of a tootlh at a time, and after-treatment in bed.
Hepatic Veno-occlusive Disease and Renal Transplantation
Authors: FERNANDO LIAÑO
Journal: Annals of Internal Medicine (1986)

Letters and Corrections1 October 1986Hepatic Veno-occlusive Disease and Renal TransplantationFERNANDO LIAÑO, ALBERTO MORENO, JOSé LUIS TERUEL, SANTIAGO LAMAS, RAFAEL MATESANZ, JOAQUÍN ORTUÑOFERNANDO LIAÑOSearch for more papers by this author, ALBERTO MORENOSearch for more papers by this author, JOSé LUIS TERUELSearch for more papers by this author, SANTIAGO LAMASSearch for more papers by this author, RAFAEL MATESANZSearch for more papers by this author, JOAQUÍN ORTUÑOSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-4-625 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Up to now, 15 cases of hepatic veno-occlusive disease have been reported in recipients of renal transplants treated with azathioprine (1-3). Read and colleagues (1) suggest a direct role of azathioprine in the pathogenesis of this disease. The small number of patients in which this clinicopathologic diagnosis has been established is surprising, however, considering the many thousand of transplant recipients treated with this drug all over the world. Nevertheless, we agree with Read and colleagues that a high index of suspicion is required, especially from the pathologic viewpoint.Azathioprine and veno-occlusive disease may be only casually related,...References1. READWIESNERLABRECQUE ARD. Hepatic veno-occlusive disease associated with renal transplantation and azathioprine therapy. Ann Intern Med. 1986;104:651-5. LinkGoogle Scholar2. KATZKASAULJORKASKYSIGALREYNOLDSSOLOWAY DSDHJR. Azathioprine and hepatic venoocclusive disease in renal transplant patients. Gastroenterology. 1986;90:446-54. CrossrefMedlineGoogle Scholar3. LIAÑOFERNÁNDEZMORENO FAA. Veno-occlusive disease of the liver. A problem in renal transplantation [Abstract]? Kidney Int. 1985;28:380. Google Scholar4. PAPPASMALONERABINHOOTNAGLEJONES SDLJE. Hepatic veno-occlusive disease in a patient with systemic lupus erythematosus. Arthritis Rheum. 1984;27:104-8. CrossrefMedlineGoogle Scholar5. MCDONALDSHARMAMATTHEWSSHULMANTHOMAS GPDHE. Veno-occlusive disease of the liver after bone marrow transplantation: diagnosis, incidence and predisposing factors. Hepatology. 1984;4:116-22. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FERNANDO LIAÑO; ALBERTO MORENO; JOSé LUIS TERUEL; SANTIAGO LAMAS; RAFAEL MATESANZ; JOAQUÍN ORTUÑOAffiliations: Hospital Ramón y Cajal 28034 Madrid Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLiver Sinusoidal Endothelial Cells and Liver Injury 1 October 1986Volume 105, Issue 4Page: 625-626KeywordsDrugsPathogenesisRenal diseasesRenal transplantation ePublished: 1 December 2008 Issue Published: 1 October 1986 PDF downloadLoading ...
Heterotopic Gastric Mucosa With Adenoma of The Gall Bladder
Authors: Frederick H. Summers
Journal: JAMA (1970)

<h3>To the Editor.—</h3> Five percent of all cholecystograms show evidence of adenomyomatosis. The finding of adenomyoma with heterotopic gastric mucosa is rare with only one other case found reported. This case is documented because of its interest to surgeons, gastroenterologists, internists, roentgenologists, and pathologists. <h3>Report of a Case.—</h3> The patient was a slender 38-year-old woman, who was seen Nov 27, 1967. because of upper abdominal discomfort of five days' duration, which she described as a "knot" in the stomach accompanied by nausea but no emesis. A similar episode had occurred twice previously lasting from one to five days. During the prior two years, similar discomfort when under stress was relieved by food and milk but not antacids. There had been no melena or hematemsis. Physical findings were essentially normal except for high epigastric tenderness with no mass. A belladonna alkaloids-phenobarbital mixture and an aluminum hydroxide gel and magnesium trisilicate preparation
How much longer will patients trust us?
Authors: Christopher N Jones
Journal: BMJ (2007)

We select the letters for these pages from the rapid responses posted on bmj.com favouring those received within five days of publication of the article to which they refer.Letters are thus an early selection of rapid responses on a particular topic.Readers should consult the website for the full list of responses and any authors' replies, which usually arrive after our selection. DaviD Mcarthy
Minoxidil Treatment of Malignant Hypertension
Authors: Friedrich C. Luft
Journal: JAMA (1978)

We treated eight severely hypertensive, long-term hemodialysis patients who failed to respond to ultrafiltration or conventional medication with minoxidil rather than with bilateral nephrectomy. Control of blood pressure and relief of symptoms was achieved in all eight. In addition, three of the patients, who were all severely oliguric, recovered sufficient renal function to allow the discontinuation of dialysis. Two are presently doing well, while one died of causes unrelated to uremia or minoxidil therapy. We presently reserve bilateral nephrectomy for those hypertensive dialysis patients who are awaiting transplantation.
HCV in hepatic failure: West and East do not meet
Authors: G. K K LAU, R. WILLIAMS
Journal: Gut (1999)

See article on page 613 

Despite the identification of hepatitis C virus (HCV) as an aetiological agent of blood borne non-A, non-B (NANB) hepatitis a decade ago, its role in fulminant NANB hepatitis is still uncertain.1 In the West, HCV is only infrequently associated with NANB fulminant hepatitis. Thus, in studies from the USA, positive serum HCV RNA was reported in none of 15 cases by Wright and colleagues2 and in only two (12%) of 17 cases by Liang et al .3 Similarly, none of the 23 and 30 NANB cases in the French and English series, respectively, was positive for HCV infection.4 5 In contrast, the prevalence of serological markers of HCV infection in NANB fulminant hepatitis is much higher in the Oriental countries. In an early study from Japan, Muto et al found that seven (58%) of 12 patients with NANB fulminant hepatitis were anti-HCV (anti-C100–3) positive6; findings which were later confirmed by Yangi et al who reported detectable serum HCV RNA in 43% (3/7) of cases of NANB fulminant hepatitis.7 In Taiwan—geographically close to Japan—HCV RNA was detected in 45–50% of patients with NANB fulminant hepatitis8 9 …
Semaphorin 3E, an exception to the rule
Authors: Michael Klagsbrun, Akio Shimizu
Journal: Journal of Clinical Investigation (2010)

Class 3 semaphorins (Sema3s) regulate axon guidance, angiogenesis, tumor growth, and tumor metastasis. Neuropilins (NRPs; NRP1 and NRP2) are the cell surface receptors for the Sema3s. However, to signal, interaction of Sema3s and NRPs with plexins is obligatory. In this issue of the JCI, Casazza and colleagues report data that challenge the conventional wisdom about the role of Sema3s in tumor metastasis. As a rule, Sema3B and Sema3F, for example, are inhibitors of tumor angiogenesis, progression, and metastasis. However, Casazza et al. found that Sema3E inhibited tumor growth but atypically promoted invasiveness and metastasis. This metastatic potential was dependent on Plexin D1 expression but was independent of NRP expression. Of clinical importance, Sema3E and Plexin D1 were found to be upregulated in human colon cancer, liver metastasis, and melanoma progression.