tbuckley/cabot-search huggingface dataset:
Abstract 13000: Trends in Incidence, Invasive Management and Outcomes of Cardiogenic Shock Complicating Non ST-Segment Elevation Myocardial Infarction
Authors: Navdeep Gupta, Saurabh Aggarwal, Yu Guo, Sripal Bangalore
Journal: Circulation (2014)

Background: Cardiogenic shock complicating Acute Myocardial Infarction (AMI) is usually described in the setting of a ST-segment elevation MI (STEMI). However, the trend in incidence, invasive management and outcomes of cardiogenic shock complicating NSTEMI, are not well defined. Methods: We analyzed patients in the Nationwide Inpatient Sample (NIS) between 2002-2011 with primary discharge diagnosis of Acute Myocardial Infarction (AMI) and secondary diagnosis of cardiogenic shock. Primary outcome was trend in cardiogenic shock complicating NSTEMI. Secondary outcome was trends in in-hospital mortality. Results: We identified 6,667,087 patients with AMI among which 4,032,193(60.5% of AMI) had NSTEMI and 2,634,894(39.5%) had STEMI. Cardiogenic shock complicated , 92,654(2.3%) patients with NSTEMI and 204,389(7.8%) patients with STEMI. Among patients with cardiogenic shock, there was a steady increase in proportion of patients with NSTEMI (vs. STEMI) (23.6% to 38.0% from 2002 to 2011, p&lt;0.001). While an increasing percentage of NSTEMI shock patients underwent invasive management (55.1% to 67.3% from 2002 to 2011, p&lt;0.001) this was significant lower when compared with STEMI shock (68.0% to 84.0% from 2002 to 2011, p&lt;0.001) patients. Mortality in NSTEMI and STEMI shock patients were similar and continued to account for high in-hospital mortality (36.6% vs. 38.9%, P&lt;0.001). Conclusions: Among patients with cardiogenic shock complicating AMI, there are an increasing proportion of patients with shock complicating NSTEMI. While the percentage of patients with NSTEMI shock undergoing invasive management has increased it continues to be lower as compared to STEMI shock despite similarly high in-hospital mortality.
Abstract 4483: IO125, a novel Pt-based supramolecular therapeutic exhibits increased anti-cancer efficacy compared with oxaliplatin
Authors: Monideepa Roy, Sk Samad Hossain, Arindam Sarkar, Aniruddha Sengupta, Nimish Gupta, Sajid Hussain, Aasif Ansari, Sanghamitra Mylavarapu, Shiladitya Sengupta
Journal: Cancer Research (2014)

Abstract Despite the widespread use of platinum chemotherapy, only few drugs have been approved in this class of molecules. Here, we describe a novel supramolecular chemistry-based platform technology to engineer more potent oxaliplatin analogues. In IO125, a unique platinum (II) is tethered to a cholesterol backbone via a monocarboxylato bond and an N→Pt coordination environment, releasing diaminocyclohexane (DACH)-platinum in a sustained pH-dependent manner. The molecule facilitates assembly into defined nanoscale supramolecular structures of uniform size distribution as measured using dynamic light scatter and electron microscopy. Such a supramolecular therapeutic demonstrates enhanced activity compared with oxaliplatin in 4T1 and MDA-MB-231 triple negative breast cancer lines. The uptake of IO125-based supramolecular therapeutic was 10-20 fold greater than free oxaliplatin in these cells. In addition, the nanoparticles exhibited significantly lower IC50 values in comparison to oxaliplatin in primary colorectal carcinoma lines generated from patient tumor sample. Nanostructures have been shown to exhibit superior pharmacokinetics profile and biodistribution to tumors due to an enhanced permeability and retention (EPR) effect. Based on these observations, we anticipate an IO125-based supramolecular therapeutic may emerge as a novel next-generation platinum-based potent anti-cancer agent. Citation Format: Monideepa Roy, Sk Samad Hossain, Arindam Sarkar, Aniruddha Sengupta, Nimish Gupta, Sajid Hussain, Aasif Ansari, Sanghamitra Mylavarapu, Shiladitya Sengupta. IO125, a novel Pt-based supramolecular therapeutic exhibits increased anti-cancer efficacy compared with oxaliplatin. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4483. doi:10.1158/1538-7445.AM2014-4483
“Lollipop” Provides Vision Assist
Authors: Rebecca Voelker
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SOME ASPECTS OF THE PSYCHONEUROSES
Authors: Annette C. Washburne
Journal: Annals of Internal Medicine (1940)

Article1 February 1940SOME ASPECTS OF THE PSYCHONEUROSESANNETTE C. WASHBURNE, M.D., F.A.C.P.ANNETTE C. WASHBURNE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-8-1388 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor practical purposes the psychoneuroses may be viewed as "exhibitions of maladjustment" of the individual to his environment. The term maladjustment has been subject to considerable criticism and discussion. Some have interpreted it as applying only to the reactions of the individual to situational factors, others have used it as a yardstick in the differentiation of the psychoses and the psychoneuroses, while to many the term is merely an unsatisfactory ambiguity.In its broadest sense it would appear that maladjustments may involvephysiologicalas well aspsychologicalconsiderations—reactions of the total organism to environmental changes interpreted as hostile or threatening...Bibliography1. KAHN E: Psychopathic personalities, 1931, Yale University Press, New Haven. Page 69. Google Scholar2. YEAGERBALDES CLEJ: Proc. Staff Meet., Mayo Clinic, 1937, xii, 705. Google Scholar3. BRAINESS S: Analysis of mitogenitic blood radiation in mental disease as basis for therapy, Jr. Nerv. and Ment. Dis., 1937, lxxxvi, 24. CrossrefGoogle Scholar4. MORGANGREGORY LCHS: Pathological changes in the tuber cinereum in groups of psychoses, Jr. Nerv. and Ment. Dis., 1935, lxxxii, 286. DAVIDSON, G. M.: Concerning the cause of death in certain psychoses, Am. Jr. Psych., 1934, xci, 41. CrossrefGoogle Scholar5. PAPEZ JW: A proposed mechanism of emotions, Arch. Neur. and Psych., 1937, xxxviii, 725. CrossrefGoogle Scholar6. MUNCIE W: Depressions with tension, Arch. Neur. and Psych., 1934, xxxii, 328. CrossrefGoogle Scholar7. FREUDBREUER SJ: Studies in hysteria, 1936, Nervous & Mental Diseases Publishing Company, Page 7. Google Scholar8. ADLER A: Problems of neurosis, 1930, Cosmopolitan Book Corporation, New York. Google Scholar9. KEMPF EJ: Psychopathology, 1921, C. V. Mosby Co., St. Louis. Google Scholar10. WASHBURNE AC: Bromism, a review of the more recent literature and analysis of sixteen new cases, Wisconsin Med. Jr., Oct., 1934. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ANNETTE C. WASHBURNE, M.D., F.A.C.P.Affiliations: Madison, Wisconsin*Received for publication December 8, 1938.From the Dept. of Student Health, University of Wisconsin.From material presented before the Green and Waushara County Medical Societies, October 17, 1938. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1940Volume 13, Issue 8 Page: 1388-1398 Keywords Psychoses ePublished: 1 December 2008 Issue Published: 1 February 1940 PDF downloadLoading ...
Rapid Proliferation of Sublines of NCTC Clone 929 (Strain L) Mouse Cells in a Simple Chemically Defined Medium (MB 752/1)2
Authors: Charity Waymouth
Journal: JNCI Journal of the National Cancer Institute (1959)

Journal Article Rapid Proliferation of Sublines of NCTC Clone 929 (Strain L) Mouse Cells in a Simple Chemically Defined Medium (MB 752/1) Get access Charity Waymouth Charity Waymouth Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 22, Issue 5, May 1959, Pages 1003–1017, https://doi.org/10.1093/jnci/22.5.1003 Published: 01 May 1959 Article history Received: 09 January 1959 Published: 01 May 1959
Regulation of Cholesterol Metabolism in the Dog
Authors: Demetrius Pertsemlidis, Ernest H. Kirchman, E. H. Ahrens
Journal: Journal of Clinical Investigation (1973)

Six adult pedigreed dogs were studied as long as 3 yr in order to determine the effects of cholesterol feeding and of bile diversion on absorption, synthesis, and storage of cholesterol. These measurements were based on cholesterol balance and isotope kinetic studies. In the six dogs fed a "cholesterol-free" diet with their enterohepatic circulations undisturbed, the rate of cholesterol synthesis ranged from 225 to 508 mg/day (mean 325 mg/day or 12.4 mg/kg/day). In two dogs studied subsequently on cholesterol-containing diets, absorption of cholesterol averaged 81% (range 71-94%) on a dietary intake of 0.5 g/day; on high cholesterol intakes (2.7-3.0 g/day) the rate of absorption dropped to 43-51% of daily intake, but the absolute amounts absorbed were increased. Feeding of cholesterol resulted in acceleration of bile acid formation and excretion, as well as nearly total inhibition of cholesterol synthesis. These two compensatory mechanisms were sufficient to maintain zero balance of cholesterol in the face of a high cholesterol intake. Plasma cholesterol concentrations in the two dogs increased by 37 and 44%. In two other dogs bile was completely diverted into the urinary system for nearly 2 yr. When these dogs were studied on a cholesterol-free diet, the sum of acidic steroids excreted daily in urine plus neutral steroids excreted in feces was seven times as high as before the operation. Since these massive excretory losses could not have been sustained by mobilization from tissue cholesterol pools, and since the rate of disappearance of [4-(14)C]cholesterol from the plasma after single intravenous injection was greatly increased after complete biliary diversion, total daily synthesis of cholesterol must have been greatly accelerated, for synthesis was totally unsuppressed. The increased output of fecal neutral steroids could be the result of transfer of plasma cholesterol across the gut wall or due to increased synthesis in the gut. Plasma cholesterol levels were reduced in these two dogs by 20 and 27%, and triglycerides decreased by 36 and 43%. Accumulation of cholesterol in body pools in the cholesterol-fed dogs appeared to have been prevented, according to antemortem measurements: increased absorption of dietary cholesterol was exactly balanced by suppression of cholesterol synthesis and enhanced bile acid excretion. In the bile-shunted animals, depletion of tissue stores of cholesterol could not be predicted by antemortem measurements.
Resistance training improves metainflammation and body composition in obese adolescents
Authors: Rachana Dayiha, Sarah P. Schultz, John Cardinal, Nuala Byrne, Andrew P. Hills, Kristen Gibbons, Louise S. Conwell, Mark Harris, Gary M. Leong
Journal: Endocrine Reviews (2014)

Background: Adolescent obesity is associated with inflammation, insulin resistance and prediabetes. Resistance training (RT) may have anti-inflammatory effects and decrease the risk of Type 2 diabetes. Objective: To investigate whether resistance training (RT) improves the adipokine profile, body composition and insulin sensitivity of obese adolescents. Methodology: Fourteen obese adolescents (16.1+1.6 y; M:F 6:8; body mass index (BMI) SDS 2.01 + 0.31) were recruited for a 16-week RT intervention. Thirty-one lean youth (15.6+1.3 y; M:F 19:12; BMI SDS -0.03+0.07) had baseline anthropometric measurements and blood tests for comparison. Participants completed 3 RT sessions per week with training load progressively increased from 60% to 85% of one repetition maximum (1-RM). The following parameters were examined pre- and post-intervention: 1) Height, weight, BMI; 2) High sensitivity C-reactive protein (hs-CRP) and adipokines including interleukin (IL)-1b, IL-6, tumor necrosis factor-alpha (TNF-a), adiponectin, soluble intercellular adhesion molecule (sICAM)-1, leptin and resistin; 3) Body composition by dual energy x-ray absorptiometry (DXA), and 4) Insulin sensitivity by homeostatic model assessment (HOMA-IR). Results: Obese youth had significantly higher IL-1b, leptin and resistin (all p<0.0001) and lower adiponectin and sICAM-1 (both p<0.0001) at baseline compared with lean youth. Post-intervention, a reduction in IL-6 (p<0.01), IL-1b (p<0.01) and resistin (p <0.001) was observed whereas adiponectin and sICAM-1 increased (p<0.05, p<0.001 respectively) in obese adolescents. HOMA and hs-CRP remained unchanged. IL-1b and sICAM-1 levels in obese youth normalised to levels comparable to lean youth post-intervention (p = 0.1 and p=0.2), whereas TNF- a and resistin were significantly lower (p<0.05, p<0.01 respectively) post-intervention in the obese youth. Percent fat for the trunk, arm and total body (p<0.05) were reduced, while fat free mass (p<0.01) was increased after the intervention. Conclusions: RT is a feasible intervention to improve the adipokine profile and body composition of obese adolescents suggesting it may be a feasible intervention for improving metabolic health in obese youth at high risk of type 2 diabetes.
Abstract 250: Sulindac delayed and suppressed the tumor progression, was not effective on inhibition of tumor initiation in a human colorectal cancer mouse model (CPC;Apc mouse)
Authors: Tomohiro Adachi, Takao Hinoi, Yuu Sasaki, Manabu Shimomura, Yasufumi Saito, Masashi Miguchi, Hiroaki Niitsu, Yuusuke Sotomaru, Naohide Oue, Wataru Yasui, Hideki Ohdan
Journal: Cancer Research (2014)

Abstract Purpose Non-steroidal anti-inflammatory drugs (NSAIDs) have shown potential as chemopreventive agents against cancer formation, especially colorectal cancers. However, the mechanisms by which these drugs act are not fully understood. In this study, CPC;Apc mice, a human colorectal cancer mouse model treated with sulindac, were evaluated according to tumor initiation and prognosis and gene expression profile of the tumors were analyzed. Methods CPC;Apc mice, originating from ApcFlox/wt mice harbor a Cdx2-Cre transgene in which colorectal tumorigenesis was driven by Apc allelic loss and represent a genetic model of human colorectal cancer (CRC) were treated with control (n=20) or sulindac (160ppm, n=22) for 12 weeks and their colorectal tumors were evaluated. Gene expression analysis was performed to identify genes differentially expressed in tumor cells from sulindac-treated mice. The gene expression was validated through quantitative real-time polymerase chain reaction in vivo. Results Body weight of mice with control or sulindac was no significantly difference ( P = 0.801). However, we observed that sulindac significantly suppressed the tumor progression relative to untreated controls (the colon tumors size per mouse: median of 4.2mm, range 2.3-5.9 versus 5.0mm, range 3.1-8.7, respectively ; P = 0.007 ), but not the initiation (the colon tumor numbers per mouse: median of 1.5, range 0-5 versus 1.0 tumors, range 0-8 respectively ; P = 0.979) in CPC;Apc mice. We identified some upregulated (n = 6, &amp;gt;1.4 fold ) and downregulated (n = 5, &amp;gt;1.4 fold) target genes by microarray assay. We validated expression of these candidate genes in human colorectal cancer. Conclusion We have identified for the first time that sulindac affected tumor progression by delayed and suppressing it, but had no effect on the initiation of tumor in CRC mice model. Citation Format: Tomohiro Adachi, Takao Hinoi, Yuu Sasaki, Manabu Shimomura, Yasufumi Saito, Masashi Miguchi, Hiroaki Niitsu, Yuusuke Sotomaru, Naohide Oue, Wataru Yasui, Hideki Ohdan. Sulindac delayed and suppressed the tumor progression, was not effective on inhibition of tumor initiation in a human colorectal cancer mouse model (CPC;Apc mouse). [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 250. doi:10.1158/1538-7445.AM2014-250
Abstract 3766: The response of cervical cancer cells to chemotherapeutic agents depends on endogenous ROS levels as well as the drug-induced ROS profile
Authors: Maria Filippova
Journal: Cancer Research (2014)

Abstract Worldwide, cervical cancer is the second most common cancer in women; approximately 400,000 new cases of this disease are diagnosed each year, of which approximately half will lead to death. Treatment of advanced and relapsed cervical cancer is frequently ineffective, due in large part to chemoresistance. To examine the pathways responsible, we employed the cervical carcinoma-derived SiHa and CaSki cells as cellular models of resistance and sensitivity, respectively, to treatment with chemotherapeutic agents. In particular, CaSki cells are much more sensitive than are SiHa cells to cell death induced by doxorubicin and cisplatin. In this study, we compared the proteomic profiles of SiHa and CaSki cells, and identified pathways with the potential to contribute to the differential response. Based on the results from this proteomic analysis, we hypothesized that pathways involved in the regulation of reactive oxygen species (ROS) levels might contribute in to the observed difference in how these two cell lines respondse to chemotherapy. We then extended these findings by analyzing and comparing the expression level of genes involved in reactive oxygen species (ROS) metabolism through the use of an RT PCR array, and. We found outdiscovered that cells resistant and sensitive cells to drug treatment had displayed different expression levels of expression of pro- and anti-oxidant enzymes. Decreasing or increasing oxidative stress led to protection or sensitization, respectively, to drug-induced cell death, supporting the idea that cellular levels of oxidative stress affect responsiveness to treatment. Interestingly, the two agents tested, doxorubicin and cisplatin, induced different profiles of ROS, and these differences appear to contribute to the differential sensitivity displayed by cervical cancer cells to treatment. Overall, our findings demonstrate that cervical cancer cells display variable profiles with respect to their redox-generating and -adaptive systems, and that these different profiles have the potential to contribute to their differential responses to treatments with chemotherapeutic agents. Citation Format: Maria Filippova. The response of cervical cancer cells to chemotherapeutic agents depends on endogenous ROS levels as well as the drug-induced ROS profile. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3766. doi:10.1158/1538-7445.AM2014-3766
Ferritin trends do not predict changes in total body iron in patients with transfusional iron overload
Authors: Mammen Puliyel, Richard Sposto, Vasilios A. Berdoukas, Thomas C. Hofstra, Anne Nord, Susan Carson, John Wood, Thomas D. Coates
Journal: American Journal of Hematology (2013)

Ferritin levels and trends are widely used to manage iron overload and assess the efficacy of prescribed iron chelation in patients with transfusional iron loading. A retrospective cohort study was conducted in 134 patients with transfusion-dependent anemia, over a period of up to 9 years. To determine whether the trends in ferritin adequately reflect the changes in total body iron, changes in ferritin between consecutive liver iron measurements by magnetic resonance imaging (MRI) were compared to changes in liver iron concentrations (LIC), a measure of total body iron. The time period between two consecutive LIC measurements was defined as a segment. Trends in ferritin were considered to predict the change in LIC within a segment if the change in one parameter was less than twofold that of the other, and was in the same direction. Using the exclusion criteria detailed in methods, the trends in ferritin were compared to changes in LIC in 358 segments. An agreement between ferritin trends and LIC changes was found in only 38% of the 358 segments examined. Furthermore, the change in ferritin was in opposite direction to that of LIC in 26% of the segments. Trends in ferritin were a worse predictor of changes in LIC in sickle cell disease than in thalassemia (P < 0.01). While ferritin is a convenient measure of iron status; ferritin trends were unable to predict changes in LIC in individual patients. Ferritin trends need to be interpreted with caution and confirmed by direct measurement of LIC.
Requesting necropsies
Authors: J. Turner, B. Raphael
Journal: BMJ (1997)

As medicine increasingly acknowledges and even welcomes the active participation of patients and their families in medical care, it is timely to investigate the attitudes of relatives towards necropsies. Any request for a necropsy is necessarily conducted at a time of greatest grief, distress, and uncertainty; and those deaths where a necropsy is required are often those where the bereavement is sudden or otherwise traumatic, and thus likely to be associated with shock, denial, and dissociation. The relatives' mental state is likely to make the request more difficult to deal with and the ultimate outcome of the loss more problematic.1 Thus, requests may be countered with anger, resentment, or rejection.

Attitudes towards necropsy are shaped by personal and cultural …