tbuckley/cabot-search huggingface dataset:
CAN THE PRACTICE OF INTERNAL MEDICINE BE EVALUATED?
Authors: C W EISELE, V N SLEE, R G HOFFMANN
Journal: Annals of Internal Medicine (1956)

Article1 January 1956CAN THE PRACTICE OF INTERNAL MEDICINE BE EVALUATED?C. WESLEY EISELE, M.D., F.A.C.P., VERGIL N. SLEE, M.D., ROBERT G. HOFFMANN, Ph.D.C. WESLEY EISELE, M.D., F.A.C.P.Search for more papers by this author, VERGIL N. SLEE, M.D.Search for more papers by this author, ROBERT G. HOFFMANN, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-1-144 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCan the practice of internal medicine be evaluated? The casual answer to this question is that it can't be done. But as a matter of fact, whether we recognize it or not, we all assume that it can. We even go further, and make the assumption that we know how to do it. Accredited hospitals are required to keep certain records attesting to the quality of care. For example, each clinical record is expected to carry the information that the patient was discharged as "RECOVERED," "IMPROVED," "UNIMPROVED" or "DEAD." It is reasoned that the hospital or the physician with the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Thirty-sixth Annual Session of the American College of Physicians, Philadelphia, Pennsylvania, April 28, 1955.From the Department of Medicine, University of Colorado School of Medicine, and the Professional Activity Study of the Southwestern Michigan Hospital Council. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEvaluating the Quality of Medical CareEvaluation in clinical practice: problems, precedents and principlesChanging clinical practice: Which interventions work?Measurement of actions of care-providers in long-term careTwenty Years of Research on the Quality of Medical CarePEER REVIEW IN THE U.S.A.: AN HISTORICAL PERSPECTIVEIntroductionPain in gynecologic practiceDoctors and Their Autonomy: Past Events and Future ProspectsThe Quality of Medical CareQuality of health care for the disadvantagedThe changing face of medicineThe quality of medical care: Techniques and investigation in the outpatient clinic“Psychogenic” pain and the pain-prone patient"Psychogenic" PainSTANDARDS OF PRACTICE OF INTERNAL MEDICINE AND METHODS OF ASSESSING THE QUALITY OF PRACTICE IN HOSPITALSMARION A. BLANKENHORN, M.D. 1 January 1956Volume 44, Issue 1Page: 144-161KeywordsAppendectomyAppendicitisBlood sugarHealth care qualityHospital medicinePneumoniaPopulation statisticsSurgeonsTest statisticsThorax ePublished: 1 December 2008 Issue Published: 1 January 1956 PDF downloadLoading ...
Abstract 19744: Protective Effect of Nrf2 on Ischemia-reperfusion Injury in Murine Heart Transplantation
Authors: Hiroyuki Kawajiri, Arash Ghashghai, Laura Tumiati, Julieta Lazarte, Liza Grossman-Rimon, Filio Billia, Ren-ke Li, Vivek Rao
Journal: Circulation (2014)

Background: Oxidative stress plays a critical role in mediating tissue injury and cellular apoptosis during ischemia-reperfusion injury (IRI). Nrf2 is a transcription factor regulating antioxidant defenses by inducing phase II enzymes, including superoxide dismutase (SOD). However, there are few studies investigating its role in heart transplantation (HTx). In this study, we examined the protective potential of Nrf2 and the Nrf2 inducer, Sulforaphane (SFN), against IRI using a murine neck HTx model.

Methods: (1) in vitro study: We treated human coronary artery smooth muscle cells (HCASMC) with 25uM SFN for 24 hours and evaluated Nrf2 expression as well as whole cell SOD activity. (2) in vivo study: We gave 25mg/kg SFN on C57BL/6J wild-type (WT) and Nrf2 knockout (KO) mice, and measured Nrf2 expression and mitochondrial SOD activity on their hearts. (3) HTx study: WT mice were used as recipients, and WT and KO mice were used as donors. 25mg/kg SFN or saline were injected 1 day prior to surgery and after surgery. Donor hearts were perfused with 25uM SFN or saline and stored in the solution for 2 hours to induce IRI. Echocardiography was done after 24 hours reperfusion.

Results: (1) SFN induced Nrf2 on HCASMC (1181.5±68.1 % control, p<0.01, n=4). SFN also increased whole cell SOD activity (112.5±2.93 vs 29.9±1.25 U/mg protein in control, p<0.01, n=4) (2) SFN induced Nrf2 in WT after 2 hours of injection (161.1±5.8 % control, p<0.01, n=4). SFN also increased mitochondrial SOD activity in WT after 24 hours of injection. However, this upregulation was absent in KO (Figure1). (3) The %FAC of donor hearts was significantly higher in WT-SFN than WT-Saline after 24 hours reperfusion. KO-Saline and KO-SFN showed similarly lower %FAC than WT (Figure2).

Conclusion: Our results suggested that Nrf2 protects against ischemia-reperfusion injury in heart transplantation. The Nrf2 inducer Sulforaphane may represent novel therapy to prevent ischemia-reperfusion injury in heart transplantation.

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Abstract B96: Non-viral gene therapy for pancreatic cancer, from preclinical models to phase II clinical trial
Authors: Louis Buscail, Barbara Bournet, Fabienne Vernejoul, Gilles Cambois, Hubert Lulka, Naima Hanoun, Aline Meulle, Alix Vignolle-Vidoni, Odile Barbey, Fabian Gross, Rosine Guimbaud, Philippe Ottal, Gérard Tiraby, Pierre Cordelier
Journal: Cancer Research (2015)

Abstract To date, pancreatic adenocarcinoma (PDAC) can’t be diagnosed early. Consequently, a majority of patient (80%) display an advanced disease that results in a low resection rate leading to a dismal overall median survival of less than 6 months. We extensively demonstrated that delivering SSTR2, DCK and UMK genes using non-viral vectors strongly inhibit tumor progression and dissemination in relevant experimental models of PDAC. Consequently, we designed a GMP-grade gene therapy product, namely CYL-02, encoding for the above mentioned therapeutic proteins, delivered by a non-viral vector for the management of 24 patients diagnosed with advanced PDAC. In this phase I clinical trial, gene therapy was administered in dose-escalation in the tumors using endoscopic ultrasound. Patients received gemcitabine during this protocol. We demonstrate that the intratumoral injection of the gene therapy product is feasible, well tolerated and safe, and results in the presence and the expression of CYL-02 in the tumors. Consequently, tumor progression is inhibited during the course of the protocol. In patients with locally advanced PDAC at the time of diagnosis, tumor size and serum levels of CA 19-9 significantly decreased following gene therapy regardless of the previous lines of treatment and median progression free survival and median overall survival reaches 6.4 and 11.4 months respectively. In addition, we carried out several advanced proteomic and circulating miRNAs analyses to identify diagnostic biomarkers predictive and/or indicative of treatment response and follow-up, to select clinical trial participants and/or to tailor therapy for individual patient. We already identified several biomarkers of clinical interest using either CE-MS (capillary electrophoresis coupled with mass spectrometry) or high throughput q(RT)PCR for peptide and miRNA identification, respectively, to create a clear prescription path for gene therapy in forthcoming clinical trials. Based on these preliminary yet very encouraging results, we propose that patients may clinically benefit from this approach. Accordingly, we are now entering phase II clinical trial using CYL-02 gene therapy product in patients diagnosed with locally advanced PDAC. Citation Format: Louis Buscail, Barbara Bournet, Fabienne Vernejoul, Gilles Cambois, Hubert Lulka, Naima Hanoun, Aline Meulle, Alix Vignolle-Vidoni, Odile Barbey, Fabian Gross, Rosine Guimbaud, Philippe Ottal, Gérard Tiraby, Pierre Cordelier. Non-viral gene therapy for pancreatic cancer, from preclinical models to phase II clinical trial. [abstract]. In: Proceedings of the AACR Special Conference on Pancreatic Cancer: Innovations in Research and Treatment; May 18-21, 2014; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2015;75(13 Suppl):Abstract nr B96.
EARLY SIGNS OF ORTHOPEDIC CONDITIONS
Authors: John Joseph Nutt
Journal: Annals of Internal Medicine (1940)

Article1 December 1940EARLY SIGNS OF ORTHOPEDIC CONDITIONSJOHN JOSEPH NUTT, M.D., F.A.C.S.JOHN JOSEPH NUTT, M.D., F.A.C.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-6-1050 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBelieving that few physicians other than orthopedic surgeons pay more than the slightest attention to the body mechanism, the writer deems it worth while to present a paper on the early signals of abnormalities in the framework of the body and their significance. If what is here offered to the profession serves to quicken the family physician's powers of observation, in the writer's opinion, at least, it will not have been written in vain.Many orthopedic conditions manifest their presence by sending out some faint signal long before subjective signs draw them to the attention of the patient, and if... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York City*Received for publication April 19, 1940. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1940Volume 14, Issue 6Page: 1050-1064KeywordsOrthopedicsSurgeons Issue Published: 1 December 1940 PDF DownloadLoading ...
Variant genotypes of FcγRIIIA influence the development of Kaposi's sarcoma in HIV-infected men
Authors: Thomas Lehr nbecher, Charles B. Foster, Shaoxian Zhu, David Venzon, Seth M. Steinberg, Kathleen Wyvill, Julia A. Metcalf, Sandra S. Cohen, Joseph Kovacs, Robert Yarchoan, Andrew Blauvelt, Stephen J. Chanock
Journal: Blood (2000)
Adverse prognostic impact of KIT mutations in childhood CBF-AML: the results of the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 trial
Authors: M Tokumasu, C Murata, A Shimada, K Ohki, Y Hayashi, A M Saito, J Fujimoto, K Horibe, M Nagao, H Itoh, Y Kamikubo, H Nakayama, A Kinoshita, D Tomizawa, T Taga, A Tawa, S Tanaka, T Heike, S Adachi
Journal: Leukemia (2015)
Updates from the British Association of Dermatologists 91st Annual Meeting, 5-7 July 2011, London, U.K.
Authors: P. De Mozzi, A.B. Alexandroff, G.A. Johnston
Journal: British Journal of Dermatology (2012)

This is a synopsis of the significant research and clinical papers presented at the British Association of Dermatologists (BAD) meeting held on the 5-7 July 2011 in London, U.K. The conference and satellite symposia highlighted the recent biological, epidemiological and therapeutic advances in dermatology. This report is not meant as a substitute for reading the conference proceedings and related references quoted in this article.
Abstract P138: Apolipoprotein CIII Is Associated With Risk Of Diabetes And Defines A High-density Lipoprotein Subtype That Isn’t Protective
Authors: Majken K Jensen, Junlong Li, Kenneth J Mukamal, Jeremy D Furtado, Anne Tjoenneland, Kim Overvad, Tianxi Cai
Journal: Circulation (2014)

Background: Apolipoprotein CIII (apoCIII) is a proinflammatory protein that may affect insulin sensitivity by promoting β-cell apoptosis. ApoCIII is present on some lipoproteins (HDL, LDL and VLDL). We hypothesized that the presence of apoCIII on HDL may modulate the inverse association of HDL with risk of diabetes. Aim: To investigate relations of concentrations of apoCIII in plasma, the concentration of apoCIII in HDL, and HDL subtypes defined according to presence and absence of apoCIII with risk of diabetes. Methods: Concentrations of total apoCIII, apoCIII in HDL, and HDL-cholesterol in plasma separated according to apoCIII (by immunoaffinity chromatography) were assessed in 3,459 initially healthy women and men from the prospective Danish Diet, Cancer and Health Study. Between 1994 and 2007, 439 incident diabetes events occurred. We used standard inverse probability weighted estimators to resample the original study population (n=57,053). Results: In multivariable Cox regression models, total apoCIII concentration was statistically significantly associated with risk of diabetes (Hazard Ratio [HR] was 3.5, 95% CI=1.9-6.5 comparing extreme quintiles). The concentration of apoCIII within HDL was not associated with risk of diabetes, but when HDL was separated according to presence and absence of apoCIII, only HDL without apoCIII was inversely associated with diabetes (HR= 0.5, 95% CI=0.3-0.9 comparing extreme quintiles), whereas HDL with apoCIII was not associated with diabetes (HR= 1.0, 95% CI= 0.5-2.0)(Figure). The associations of the two HDL fractions were significantly different (p for heterogeneity = 0.002) and added significant information above and beyond the measure of total HDL (p=0.01). Conclusion: ApoCIII is associated with risk of diabetes. Further, while the concentration of apoCIII in HDL is not associated with diabetes risk, the presence of apoCIII on HDL may mark a dysfunctional subtype of HDL that lacks a protective association with diabetes.
Abstract 16496: Circulating Systemic Factors from Young Mice Reverse Age-Related Cardiac Hypertrophy
Authors: Francesco S Loffredo, Matthew L Steinhauser, Jack Tian, Joseph Gannon, Jennifer Shadrach, Christine Miller, Christie L Pizzimenti, Amy J Wagers, Richard T Lee
Journal: Circulation (2011)

Francesco S Loffredo, 2011 Finalist and Presenting Author
Abstract 12732: Coronary Stent Fracture Promotes Neoatherosclerosis Formation in-Stent Restenotic Neointimal Tissue After Drug-Eluting Stent Implantation
Authors: Yasuhiro Uchida, Satoshi Ichimiya, Hideo Oishi, Toshijiro Aoki, Yusuke Miki, Toshiki Kawamiya, Hitoshi Ichimiya, Junji Watanabe, Masaaki Kanashiro, Shinji Hayano, Susumu Suzuki, Hideki Ishii, Tetsuya Amano, Tatsuaki Matsubara, Toyoaki Murohara
Journal: Circulation (2014)

Introduction:Drug-eluting stent (DES) reduced the rates of in-stent restenosis and subsequent target lesion revascularization. However, stent fracture (SF) after DES implantation has become an important concern because of its potential association with restenosis and stent thrombosis. In addition, the pathogenic impact of SF on in-stent restenotic neointimal tissue components after DES implantation remains unclear. Hypothesis:We assessed the hypothesis that SF after DES implantation might promote neoatherosclerosis formation in restenosis lesions. Methods:We enrolled 41 consecutive patients with in-stent restenosis requiring revascularization after DES implantation between January 2008 and March 2014. In advance, we excluded the patients with recurrent restenosis, thrombotic lesions, and total occlusion. For evaluation of in-stent tissue components, integrated backscatter intravascular ultrasound (IB-IVUS) was performed. SF was defined as complete or partial separation of stent segments observed by using ...
Abstract 3845: Symptoms burden in subjects with cervical cancer and supportive care:A view from a developing country
Authors: Andrew T. Olagunju, Olatunji F. Aina, Foluke O. Sarimiye, Tinuke O. Olagunju
Journal: Cancer Research (2014)

Abstract Objectives: Cervical cancer is not only a leading gynecologic cancer in the developing countries but disproportionately accounts for the burden due to cancer. In spite of the need for holistic care of cervical cancer, little is known about the experience of the affected populations beyond their cancer treatment. This study aims to investigate the pattern and distribution of symptoms burden in subjects with cervical cancer in a developing context. Methods: This cross sectional study was carried out among 122 consenting participants with cervical cancer using a designed questionnaire to elicit socio-demographic with clinical profile and symptoms burden. Subsequently, Centre for Epidemiological Studies Depression Scale Revised (CESD-R) was used to ascertain presence of depressive symptoms in participants. Data analyses were done using SPSS-15. Results: Majority of the subjects, 50(41.0%) and 68(55.7%) were in their fifth decade of life and unmarried respectively. Six (4.9%) participants presented with early stage cancer, while close to two-thirds of the participants made up of 76(62.3%) subjects had advanced stage cancer. The largest proportion, consisting of about 7 in every 10 participants had pain, 70(57.4%) participants reported sexual dysfunction, and common sexual problems that were reported include loss of libido, dyspareunia and anorganism among others. In addition, physical complications like ulcer, weight loss and multiple complaints were seen in 56(45.9%) participants. Significant depressive symptoms based on CESD-R cut-off score of 16 and above was elicited among close to half of the participants, 58(47.5%). Conclusions: Late presentation and significant burden of diverse symptoms including pain, sexual, physical and depressive were prevalent among individuals with cervical cancer. Health education with proactive health interventions to promote early presentation and supportive care to ensure qualitative overall care are implied. Citation Format: Andrew T. Olagunju, Olatunji F. Aina, Foluke O. Sarimiye, Tinuke O. Olagunju. Symptoms burden in subjects with cervical cancer and supportive care:A view from a developing country. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3845. doi:10.1158/1538-7445.AM2014-3845
ELECTROCARDIOGRAPHIC CHANGES WITH PERFORATED DUODENAL ULCER; A CASE REPORT
Authors: Lemuel C. Mcgee, Harold A. Conrad, Angus K. Wilson
Journal: Annals of Internal Medicine (1937)

Case Reports1 February 1937ELECTROCARDIOGRAPHIC CHANGES WITH PERFORATED DUODENAL ULCER; A CASE REPORTLEMUEL C. MCGEE, PH.D., M.D., HAROLD A. CONRAD, M.D., ANGUS K. WILSON, M.D.LEMUEL C. MCGEE, PH.D., M.D.Search for more papers by this author, HAROLD A. CONRAD, M.D.Search for more papers by this author, ANGUS K. WILSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-8-1222 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptC. M., male, coal-miner, aged 39 years, entered the hospital one Sunday morning in shock and semi-coma. The history, obtained from his family, was that he had been seized with severe upper-abdominal pain while walking from one room to another in his home 12 hours previously, and that he had collapsed immediately. There had been no radiation of the pain to the sternum. He had become quite short of breath following the onset of pain and could not sleep. The pain had diminished but did not disappear. The next morning, 10 hours after onset of symptoms, a physician was called...Bibliography1. BROWN TR: Cardiac symptoms in unsuspected gallbladder disease, Anniversary volumes in honor of Dr. Emanuel Libman, 1932, vol. 1, International Press, New York, 265-271. Google Scholar2. VEST WE: Anginoid symptoms of gall-bladder disease; a survey of the literature, South. Med. Jr., 1934, xxvii, 410-413. CrossrefGoogle Scholar3. CARMICHAEL JL: The relation of gall-bladder disease without jaundice to bradycardia and heart disease; case report, South. Med. Jr., 1934, xxvii, 407-410. CrossrefGoogle Scholar4. TENNANTZIMMERMAN RHM: Association between disease in the gall-bladder and in the heart, as evidenced at autopsy, Yale Jr. Biol. and Med., 1931, iii, 495-503. Google Scholar5. FITZ-HUGHWOLFERTH TCG: Cardiac improvement following gallbladder surgery, Ann. Surg., 1935, ci, 478-483. CrossrefGoogle Scholar6. WILLIUSFITZPATRICK FAJM: The relationship of chronic infection of the gallbladder to disease of the cardiovascular system, Jr. Iowa State Med. Soc., 1925, xv, 589-592. Google Scholar7. BARKERWILSONCOLLER PSFNFA: Abdominal disease simulating coronary occlusion, Am. Jr. Med. Sci., 1934, clxxxviii, 219-224. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Elkins, West Virginia*Received for publication June 20, 1936.From the Golden Clinic, Davis Memorial Hospital, Elkins, West Va. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1937Volume 10, Issue 8Page: 1222-1226KeywordsDuodenal ulcersElectrocardiographyHospitalsShockSleepSternumWalking ePublished: 1 December 2008 Issue Published: 1 February 1937 PDF downloadLoading ...
The Holy Society
Authors: Joel Stein
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cognitive functioning and posttraumatic stress disorder
Authors: D H Barrett, M L Green, R Morris, W H Giles, J B Croft
Journal: American Journal of Psychiatry (1996)

The authors examined the association of cognitive impairment with posttraumatic stress disorder (PTSD) and other psychiatric diagnoses known to affect cognitive functioning.The results of standardized neuropsychological tests were compared in four groups of Vietnam veterans: veterans with both a lifetime history of PTSD and a current diagnosis of depression, anxiety, or substance abuse; veterans with only a PTSD diagnosis; veterans with only a current diagnosis of depression, anxiety, or substance abuse; and veterans with none of these diagnoses.Veterans with both PTSD and concurrent diagnoses. exhibited more impairment in cognitive functioning than did veterans without these diagnoses.Cognitive deficits seen among persons diagnosed with PTSD may be associated with their concomitant diagnoses.
Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10
Authors: Laszlo Cervenak, Lucia Morbidelli, Daria Donati, Sandra Donnini, Taku Kambayashi, Julia L. Wilson, Håkan Axelson, Esmeralda Castaños-Velez, Hans-Gustaf Ljunggren, Rene De Waal Malefyt, Harris J. Granger, Marina Ziche, Maria Teresa Bejarano
Journal: Blood (2000)