tbuckley/cabot-search huggingface dataset:
Renal Transplant between Identical Twins.
Authors: R. S. Brittain
Journal: Annals of Internal Medicine (1963)

s1 April 1963Renal Transplant between Identical Twins.R. S. Brittain, M.D.R. S. Brittain, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-734_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhile renal transplantation between identical twins presents none of the problems of the rejection phenomenon, nonetheless certain considerations are imperative for success. The diagnosis and rate of progression of the renal disease need to be determined precisely so that the transplant may be performed at an essential time. The identical nature of the twins is frequently known, but erroneous information on this point could make the difference between acceptance and rejection. Preoperative evaluation of the twins includes studies of the donor renal function and renal vascularity in addition to the considerations of recipient dialysis, isolation, and renal complications.During operation,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Denver, Colo. (ML) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 734-734KeywordsMedical dialysisMonozygotic twinsRenal diseasesRenal transplantationTwins Issue Published: 1 April 1963 PDF DownloadLoading ...
Hazards of Mercury Thermometers
Authors: Howard C. Mofenson
Journal: JAMA (1973)

<h3>To the Editor.—</h3> In their LETTER TO THE EDITOR, Kern et al (222:88, 1972) report that "several cases of mercury poisoning have been described as a result of broken thermometers." They do not specify whether these episodes were from oral ingestion of mercury from broken thermometers or if the mercury from the thermometer was imbedded in tissue. , Each year, our Poison Control Center receives 20 to 25 calls from anxious parents whose children have bitten and broken thermometers and ingested the mercury. In regard to mercury orally ingested, we would like to make a few points of significance. Thermometers contain metallic mercury, which oxidizes too slowly in the intestinal tract to yield the mercury ion for absorption and is, therefore, not a hazard. In the past ten years, we have encountered no toxicity from this source of mercury. A small danger may exist from the broken glass. Parents
Families win support for vaccine compensation claim
Authors: C Dyer
Journal: BMJ (1994)

More than 100 families who blame their children's deaths or serious injuries on the measles, mumps, and rubella vaccine have won legal aid to investigate a possible multimillion pound claim for compensation. At least eight British children who were given the vaccine since it was introduced in 1988 have died within days or months of being vaccinated. In one case, that of 3 year old Hannah Buxton, the official tribunal dealing with vaccine damage has held that the vaccine was to blame and awarded the parents pounds sterling 20 000 compensation.

Other children who were given the vaccine have been diagnosed as having a range of disorders, including brain damage, deafness, epilepsy, speech and communication problems, arthritis, and immunodeficiency …
Do pigmented naevi in albinism provide evidence of tyrosinase positivity?
Authors: M. AKIYAMA, H. SHIMIZU, M. SUGIURA, T. NISHIKAWA
Journal: British Journal of Dermatology (1992)

We investigated a 4-year-old Japanese boy with oculocutaneous albinism who had a solitary pigmented mole measuring 5 mm in diameter on his back. An electron microscopic tyrosine incubation test and a DOPA reaction test clearly demonstrated the presence of tyrosinase activity in the patient's hypopigmented skin. The presence of tyrosinase activity was confirmed by tests on hair bulb samples. Histopathological evidence showed that the mole was a typical compound cellular naevus with melanin pigmentation. Although no reports to date have focused on the relationship between pigmented naevi in albinism and tyrosinase activity, our findings suggest that the occurrence of pigmented naevi in an albino may indicate the presence of tyrosinase activity.
THE IMPORTANCE OF EARLY EFFECTIVE ELIMINATION IN THE ZYMOTIC DISEASES OF CHILDREN.Read in the Section on Diseases of Children at the Forty-fourth Annual Meeting of the American Medical Association.
Authors: J. A. WORK
Journal: JAMA (1893)

The physician who has the ambition to keep pace with the advance of his chosen profession, and learns with delightful anticipations the most approved and modern remedy for the special disease in question— with its therapeutical application in detail—will in a great measure fail of the desired end, if he loses sight of the very important fact, that he has a system—a body of many members—to treat, as well as a disease to combat. A system already in a pathologic condition, and was so, as, in a majority of cases, even prior to the inception of the specific zymotic poison. When we are interrogated, why all children equally exposed to a certain contagion, do not contract the same? we answer that those who are not affected are in good habit of system; their blood is pure; they are in a healthy condition; by which expressions we mean to say, that
Lipoprotein(a) concentrations in non-insulin-dependent diabetes mellitus and borderline hyperglycemia: A population-based study
Authors: Giuseppina Imperatore, Angela Rivellese, Rocco Galasso, Egidio Celentano, Ciro Iovine, Assiamira Ferrara, Gabriele Riccardi, Olga Vaccaro
Journal: Metabolism (1995)
Cord blood mononuclear cells and milk-specific T-cell clones are tools to evaluate the residual immunogenicity of hydrolyzed milk formulas
Authors: Zsolt Szépfalusi, Ivo Nentwich, Eva Josta, Marianne Gerstmayra, Christof Ebner, Thomas Frischer, Radvan Urbanek
Journal: Journal of Allergy and Clinical Immunology (1998)
Woman who was refused an abortion died as result of "medical misadventure," inquest finds
Authors: C. Dyer
Journal: BMJ (2013)

An Indian dentist who died from sepsis in an Irish hospital after being refused a termination under Ireland’s strict abortion law was a victim of “medical misadventure,” the inquest into her death has found.

An inquest jury in Galway delivered the unanimous verdict in the case of Savita Halappanavar, 31, who was 17 weeks pregnant when she died of sepsis at Galway University Hospital on 28 October last year, three and a half days after a miscarriage.

After the verdict the …
Protein Kinase Cα Determines HER2 Fate in Breast Carcinoma Cells with HER2 Protein Overexpression without Gene Amplification
Authors: Alessandra Magnifico, Luisa Albano, Stefano Campaner, Manuela Campiglio, Silvana Pilotti, Sylvie Ménard, Elda Tagliabue
Journal: Cancer Research (2007)

Abstract In some HER2-positive breast tumors, cell surface overexpression of HER2 is not associated with gene amplification but may instead rest in altered gene transcription, half-life, or recycling of the oncoprotein. Here, we show that HER2 overexpression in HER2 2+ carcinomas is associated with neither an increase in gene transcription nor a deregulation in the ubiquitin-dependent pathways, but instead seems to be regulated by protein kinase Cα (PKCα) activity. The stimulation of PKCα up-regulated HER2 expression, whereas PKCα inhibition by pharmacologic treatments and PKCα-specific small interfering RNA led to a dramatic down-regulation of HER2 levels only in breast cancer cells HER2 2+. Consistent with the in vitro data, our biochemical analysis of HER2 2+ human primary breast specimens revealed significantly higher levels of phosphorylated PKCα compared with HER2-negative tumors. Inhibition of HER2 activation by the tyrosine kinase inhibitor lapatinib led to decreased levels of PKCα phosphorylation, clearly indicating a cross-talk between PKCα and HER2 molecules. These data suggest that HER2 overexpression in HER2 2+ carcinomas is due to an accumulation of the recycled oncoprotein to the cell surface induced by activated PKCα. [Cancer Res 2007;67(11):5308–17]
Doctors of Public Health
Authors: Allen J. Smith
Journal: JAMA (1910)

To the Editor:—  Apropos of the editorial inThe Journal, August 20 on this subject, may I not ask your attention to the course which since 1906 has been offered by the University of Pennsylvania, and which is outlined in the special advertisement of this school in the same number ofThe Journal? Dr. Harold Wood, who graduated this spring in this course, has very recently been placed in charge of the Mississippi State Laboratory by the Board of Health of Mississippi.
Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals
Authors: Xue Ying, He Wen, Wan-Liang Lu, Ju Du, Jia Guo, Wei Tian, Ying Men, Yan Zhang, Ruo-Jing Li, Ting-Yuan Yang, De-Wei Shang, Jin-Ning Lou, Liang-Ren Zhang, Qiang Zhang
Journal: Journal of Controlled Release (2009)
Long-term L-Thyroxine Therapy Is Associated With Decreased Hip Bone Density in Premenopausal Women
Authors: Terri L. Paul
Journal: JAMA (1988)

The effect of long-term L-thyroxine (L-T4) therapy on axial skeleton bone density was studied in 31 premenopausal women; the bone densities of these women were compared with the bone densities of 31 age- and weight-matched women without thyroid or bone abnormalities. The women receiving L-T4 therapy had been receiving the medication for a minimum of five years. There was no difference in calcium intake or excretion between the L-T4-treated women and the controls. Women receiving L-T4 had increased serum thyroxine concentrations (134 +/- 5 vs 95 +/- 3 nmol/L [10.4 +/- 0.4 vs 7.4 +/- 0.2 micrograms/dL]), an increased free thyroxine index (9.4 +/- 0.4 vs 6.8 +/- 0.2), and decreased serum thyroid-stimulating hormone concentrations (0.9 +/- 0.2 mU/L vs 2.1 +/- 0.3 mU/L [0.9 +/- 0.2 vs 2.1 +/- 0.3 microU/mL]). Serum triiodothyronine concentrations were normal and were similar in both groups. Women treated with L-T4 had a 12.8% lower bone density at the femoral neck and a 10.1% lower bone density at the femoral trochanter compared with matched controls. In contrast, lumbar spine bone density was similar in the two groups. The data suggest that long-term L-T4 therapy, which is often given at supraphysiologic dosages, may predispose patients to decreased bone density in the hip and may increase the risk of age-related bone loss. It is advisable, therefore, to employ a dosage of L-T4 that is carefully monitored to avoid the long-term use of dosages that are excessive for the thyroid condition being treated.
Defective in vitro production of gamma-interferon and tumor necrosis factor-alpha by circulating T cells from patients with the hyper-immunoglobulin E syndrome.
Authors: G Del Prete, A Tiri, E Maggi, M De Carli, D Macchia, P Parronchi, M E Rossi, M C Pietrogrande, M Ricci, S Romagnani
Journal: Journal of Clinical Investigation (1989)

Circulating T cells from four patients with the hyper-IgE syndrome were found to produce significantly lower concentrations of interferon-gamma (IFN-gamma) in response to stimulation with phytohemagglutinin (PHA) than did T cells from eight age-matched healthy controls, three patients with atopic dermatitis and one patient with chronic granulomatous disease. A clonal analysis revealed that patients with hyper-IgE syndrome had markedly lower proportions of circulating T cells able to produce IFN-gamma and tumor necrosis factor-alpha (TNF-alpha) in comparison with controls. In contrast, the proportions of peripheral blood T cells able to produce IL-4 or IL-2 were not significantly different in patients and controls. All the four patients with hyper-IgE syndrome showed high proportions of circulating CD4+ helper T cells able to induce IgE synthesis in allogeneic B cells, as well. Such an activity for IgE synthesis appeared to be positively correlated with IL-4 production by T cells and inversely related to the ability of the same T cells to produce IFN-gamma. Since IFN-gamma exerts an inhibitory effect on the synthesis of IgE and both IFN-gamma and TNF-alpha play an important role in inflammatory reactions, we suggest that the defective production of IFN-gamma may be responsible for hyperproduction of IgE and the combined defect of IFN-gamma and TNF-alpha may contribute to the undue susceptibility to infections seen in patients with hyper-IgE syndrome.
Mitochondrial Uncoupling Protein 1 Expressed in the Heart of Transgenic Mice Protects Against Ischemic-Reperfusion Damage
Authors: Jacqueline Hoerter, Maria-del-Mar Gonzalez-Barroso, Elodie Couplan, Philippe Mateo, Chantal Gelly, Anne-Marie Cassard-Doulcier, Philippe Diolez, Frederic Bouillaud
Journal: Circulation (2004)

Mitochondrial respiration is the main source of energy in aerobic animal cells and is adapted to the energy demand by respiratory coupling. Uncoupling proteins (UCPs) perturb respiratory coupling by inducing a proton leak through the mitochondrial inner membrane. Although this could lead to deleterious energy waste, it may prevent the production of oxygen radicals when the rate of phosphorylation of ADP into ATP is low, whereas oxygen and substrate availability to mitochondria is high. The latter conditions are encountered during cardiac reperfusion after ischemia and are highly relevant to heart infarction.Heart function of 6 transgenic mice expressing high amounts of UCP1 and of 6 littermate controls was compared in isolated perfused hearts in normoxia, after 40-minute global ischemia, and on reperfusion. In normoxia, oxygen consumption, contractility (quantified as the rate-pressure product), and their relationship (energetic yield) were similar in controls and transgenic mice. Although UCP1 expression did not alter the sensitivity to ischemia, it significantly improved functional recovery on reperfusion. After 60 minutes of reperfusion, contractility was 2-fold higher in transgenic mice than in controls. Oxygen consumption remained significantly depressed in controls (53+/-27% of control), whereas it recovered strikingly to preischemic values in transgenic mice, showing uncoupling of respiration by UCP1 activity. Glutathione and aconitase, markers of oxidative damage, indicated lower oxidative stress in transgenic mice.UCP1 activity is low under normoxia but is induced during ischemia-reperfusion. The presence of UCP1 mitigates reperfusion-induced damage, probably because it lowers mitochondrial hyperpolarization at reperfusion.
Effect of cimetidine on portal hypertension in cirrhotic patients.
Authors: A K Burroughs, R Walt, A Dunk, W Jenkins, S Sherlock, S Mackie, R Dick
Journal: BMJ (1982)

Acute right heart failure complicated by hypovolaemiaThe dangers of inducing diuresis in patients with pulmonary oedema and normal pulmonary wedge pressures have recently been described."We report a complementary case of acute right heart failure due to right ventricular infarction complicated by hypovolaemia.In this, right ventricular output may provide an insufficient preload for the left ventricle, and there is the apparent paradox of an overloaded right ventricle and an inadequately primed "hypovolaemic" left ventricle.Failure to recognise this may lead to inappropriate diuretic or inotropic treatment and potentially irreversible hypovolaemic shock. Case reportA 66-year-old tailor presented with inferior myocardial infarction.He was normotensive and well perfused, with raised jugular venous pressure.Auscultation of the heart was normal and he had no signs of left ventricular failure.Because of the raised jugular venous pressure he underwent diuresis.Over three days he became hypotensive and oliguric.Jugular venous pressure remained raised in the absence of pulmonary congestion, and he developed ankle oedema.Inotropic drugs and diuretics produced no improvement.A Swan-Ganz catheter was inserted (figure).Right atrial pressure was W0 ...... ... ... .. xFe < .' ~~~~~~~~~.{ ...8.< Left ventricular hypovolaemia due to right ventricular infarction.Top: Pressures on insertion of catheter.Bottom: Pressures after 250 mil colloid given immedi9tely.PAP=Pulmonary artery pressure.PCWP =Pulmonary capillary wedge pressure.Insp= Inspiration.Exp = Expiration.raised with a mean systolic pressure of 12 mm Hg from the mid-axilla (normal range 12-20) and a mean pulmonary capillary wedge pressure of on 13 July
Frequency of HLA antigen in asbestos workers with and without pulmonary fibrosis.
Authors: C C Evans, H C Lewinsohn, J M Evans
Journal: BMJ (1977)

HLA antigens were determined in 37 patients with asbestosis and 37 matched controls with equivalent asbestos exposure but no pulmonary fibrosis. All had worked in the same textile factory. No significant differences in the prevalence of antigens were found between the two groups or between either group and controls who had not been exposed to asbestos. When the data were combined with findings from other pilot studies the previously suggested association between asbestosis and HLA-B27 was not confirmed. Subjects who were positive for HLA-B12 tended also to have advanced radiographic fibrosis. Asbestos workers without pulmonary fibrosis had an unexpectedly high frequency of HLA-BW5, which might indicate that this antigen protects against the development of pulmonary fibrosis.
The Evolution of National Nutrition Policy
Authors: David A. Kessler
Journal: Annual Review of Nutrition (1995)

Domestic regulatory efforts in the area of nutrition historically have focused on achieving and sustaining the highest possible level of food safety and availability. More recently, the linkages between certain dietary practices and the risk of chronic, degenerative diseases have also become a significant focus of public policy. In order to promote good nutrition practices, the Food and Drug Administration (FDA) now requires a detailed and informative Nutrition Facts food label on virtually all food packages. Other public policies promoted by the FDA and others include increasing public knowledge of the relationship between diet and health; promoting unified food and nutrition policies among all government agencies; educating the American consumer about sound dietary practices; and encouraging the development of technologies that may result in more healthful, more abundant, and more affordable foods.
An Aid for Caregivers of Patients with Dementia
Authors: James A. Levine
Journal: Annals of Internal Medicine (1994)

Letters1 June 1994An Aid for Caregivers of Patients with DementiaJames A. Levine, MD, PhDJames A. Levine, MD, PhDMayo Clinic; Rochester, MN 55905Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-11-199406010-00024 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The potential psychiatric and physical symptoms experienced by caregivers of patients with dementia are highlighted by Baumgarten and colleagues [1]. Many personal interactions outside the home environment can result in anxiety and embarrassment to both the caregiver and the patient [2]. The caregiver of one of my patients provided a novel solution.A 67-year-old woman, accompanied by her husband, came to the Urgent Care Center with abdominal pain. No past medical records were available. It became increasingly difficult to document the patient's presenting problem until her husband took from his shirt pocket a card that he had ...References1. Baumgarten M, Hanley JA, Infante-Rivard C, Battista RN, Becker R, Gauthier S. Health of family members caring for elderly patients: a longitudinal study. Ann Intern Med. 1994; 120:126-32. Google Scholar2. O'Connor DW, Pollitt PA, Roth M, Brook CP, Reiss BB. Problems reported by relatives in a community study of dementia. Br J Psychiatry. 1990; 156:835-41. Google Scholar Author, Article, and Disclosure InformationAuthors: James A. Levine, MD, PhDAffiliations: Mayo Clinic; Rochester, MN 55905 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1994Volume 120, Issue 11Page: 974KeywordsAbdominal painAlzheimer diseaseAnxietyCaregiversDementia ePublished: 15 August 2000 Issue Published: 1 June 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Aluminum in Alzheimer's disease
Authors: R. P. Mason
Journal: JAMA (1993)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pandemic Influenza Preparedness and Community Resiliency
Authors: John P. Middaugh
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acanthosis nigricans, insulin resistance and cutaneous virilism
Authors: J.H. EARTH, L.L. NG, F. WOJNAROWSKA, R.P.R. DAWBER
Journal: British Journal of Dermatology (1988)

Thirteen patients with the syndrome of acanthosis nigricans and insulin resistance are described. They all had a combination of dermatoses related to hyperandrogenism (cutaneous virilism): hirsuties (II), acne vulgaris (6), hidradenitis suppurativa (5) and androgenic alopecia (4). In addition, 9 out of 13 had keratosis pilaris. The patients had raised fasting plasma insulin levels compared with matched normal controls (P less than 0.01) and increased insulin resistance (P less than 0.02). Insulin resistance correlated with total serum testosterone (rs = 0.65; P less than 0.02).