FATAL MILIARY COCCIDIOIDOMYCOSIS COMPLICATING PROLONGED PREDNISONE THERAPY IN A PATIENT WITH MYELOFIBROSIS
Authors: John J. Castellot, Robert L. Creveling, Forrest W. Pitts
Journal: Annals of Internal Medicine (1960)

Case Reports1 January 1960FATAL MILIARY COCCIDIOIDOMYCOSIS COMPLICATING PROLONGED PREDNISONE THERAPY IN A PATIENT WITH MYELOFIBROSISJOHN J. CASTELLOT, ROBERT L. CREVELING, FORREST W. PITTSJOHN J. CASTELLOTSearch for more papers by this author, ROBERT L. CREVELINGSearch for more papers by this author, FORREST W. PITTSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-1-254 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptExperience with ACTH, hydrocortisone and similar compounds during the last decade has repeatedly shown the risk of using these agents in large doses over long periods.1, 2 This has been particularly true in tuberculosis and histoplasmosis, and in infections when its use is not accompanied with antimicrobial therapy.3, 4 The following case is believed to be the first to document the deleterious effects of adrenocortical steroid therapy on clinical coccidioidomycosis.CASE REPORTIn the third trimester of her first pregnancy, in 1950, this 37 year old white female was hospitalized for preeclampsia and found to have hepatosplenomegaly, anemia, neutrophilia with...Bibliography1. GoodVernierSmith RARLRT: Serious untoward reactions to therapy with cortisone and adrenocorticotropin in pediatric practice, Pediatrics 19: 95, 1957. MedlineGoogle Scholar2. Allenby KD: Deaths associated with steroid hormone therapy, Lancet 1: 1104, 1957. CrossrefGoogle Scholar3. Spink WW: ACTH and adrenocorticosteroids as therapeutic adjuncts in infectious diseases, New England J. Med. 257: 979, 1957. CrossrefMedlineGoogle Scholar4. MontgomeryBenedekPoske MMTGRM: Relation of ACTH and cortisone to infection, M. Clin. North America 39: 8, 1955. Google Scholar5. Levan NE: Occupational aspects of coccidioidomycosis, California Med. 80: 294, 1954. MedlineGoogle Scholar6. CavalleroSala CG: Cortisone and infection, Lancet 1: 175, 1951. CrossrefGoogle Scholar7. NewcomerWrightTarbetWinerSternberg VDETJELHTH: The effects of cortisone on experimental coccidioidomycosis, J. Invest. Dermat. 20: 315, 1953. CrossrefMedlineGoogle Scholar8. EnglemanKrupp EPMA: Clinical experiences with cortisone, Veterans Administration Conference on Cortisone Research, a symposium, August 15 and 16, 1950, pp. 28-36. Google Scholar9. LevanEinstein NEHE: Cortisone in coccidioidomycosis, California Med. 84: 193, 1956. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: San Francisco, California*Received for publication August 14, 1958.From the Department of Medicine and Pathology Service, Letterman Army Hospital, San Francisco, California.Requests for reprints should be addressed to Chief, Research and Development Service, Letterman Army Hospital, San Francisco, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEndemic Mycoses in a Cancer HospitalMiliary Coccidioidomycosis in the ImmunocompetentAcute pulmonary coccidioidomycosis mimicking bacterial pneumonia and septic shock: A report of two casesSurgery for coccidioidomycosis in 52 diabetic patients with special reference to related immunologic factorsAdrenal glucocorticoids after twenty yearsSteroid Induced Disseminated CoccidioidomycosisEXPERIENCES WITH AND DIAGNOSIS OF DISEASES DUE TO OPPORTUNISTIC FUNGI*Case 57-1961 1 January 1960Volume 52, Issue 1Page: 254-258KeywordsAdrenocorticotropic hormoneAntimicrobialsCoccidioidomycosisHistoplasmosisHospital medicinePrevention, policy, and public healthResearch laboratoriesSteroid therapyTachycardiaTuberculosis ePublished: 1 December 2008 Issue Published: 1 January 1960 PDF downloadLoading ...