ACUTE HEMOLYTIC ANEMIA, AUTOAGGLUTINATION, TOXIC HEPATITIS AND RENAL DAMAGE FOLLOWING SULFATHIAZOLE THERAPY; CASE REPORT
Authors: Isadore Rothstein, Sidney Cohn
Journal: Annals of Internal Medicine (1942)

Case Reports1 January 1942ACUTE HEMOLYTIC ANEMIA, AUTOAGGLUTINATION, TOXIC HEPATITIS AND RENAL DAMAGE FOLLOWING SULFATHIAZOLE THERAPY; CASE REPORTISADORE ROTHSTEIN, M.D., SIDNEY COHN, M.D.ISADORE ROTHSTEIN, M.D.Search for more papers by this author, SIDNEY COHN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-16-1-152 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSoon after the introduction of sulfanilamide into this country reports of various toxic manifestations following its use began to appear, among them reports of acute hemolytic anemia. Acute hemolytic anemia due to sulfanilamide administration was first described by Harvey and Janeway1in 1937 and since then has been noted by many other observers. In a large series of cases the incidence of this complication following sulfanilamide has been estimated as approximately 2.5 per cent of all adults and 8.5 per cent of all children receiving the drug.2Later studies have revealed an incidence of 1.8 per cent in all patients.3...Bibliography1. HARVEYJANEWAY AMCA: The development of acute hemolytic anemia during the administration of sulfanilamide, Jr. Am. Med. Assoc., 1937, cix, 12. CrossrefGoogle Scholar2. LONGBLISSFEINSTONE PHEAWH: Mode of action, clinical use and toxic manifestations of sulfanilamide: further observations, Jr. Am. Med. Assoc., 1939, cxii, 115. CrossrefGoogle Scholar3. LONGHAVILANDEDWARDSBLISS PHJWLBEA: The toxic manifestations of sulfanilamide and its derivatives, Jr. Am. Med. Assoc., 1940, cxv, 364. CrossrefGoogle Scholar4. BANNICKBROWNFOSTER EGAEFP: The therapeutic effectiveness and toxicity of sulfanilamide, Jr. Am. Med. Assoc., 1938, cxi, 770. CrossrefGoogle Scholar5. 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MOLITORROBINSON HH: Some pharmacological and toxicological properties of sulfanilamide and benzyl sulfanilamide, Jr. Pharm. and Exper. Therap., 1939, xlv, 405. Google Scholar18. PEPPERHORACK DSHM: Crystalline concretions in renal tubules following sulfathiazole therapy, Am. Jr. Med. Sci., 1940, cxcix, 674. CrossrefGoogle Scholar19. LONG PH: Thiazole derivatives of sulfanilamide, Jr. Am. Med. Assoc., 1940, cxiv, 870. Google Scholar20. REINHOLDFLIPPENSCHWARTZ JGHFL: Toxicology of sulfathiazole in man, Am. Jr. Med. Sci., 1940, cxcix, 393. CrossrefGoogle Scholar21. FLIPPENSCHWARTZROSE HFLSB: Comparative effectiveness and toxicity of sulfathiazole and sulfapyridine in pneumococcic pneumonia, ANN. INT. MED., 1940, xiii, 2038. Google Scholar22. BLAKE FG: The treatment of pneumococcal pneumonia, New England Jr. Med., 1940, ccxxiii, 661. CrossrefGoogle Scholar23. CUTTSBURGESSCHAFFE MAMFH: The treatment of lobar pneumonia with sulfathiazole and sulfapyridine, New England Jr. Med., 1940, ccxxiii, 762. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bronx, New York*Received for publication February 25, 1941.From the Departments of Pathology and Medicine, The Bronx Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrugs, Chemicals and HemolysisRenal Damage Following Intravascular HemolysisThe influence of phenolphthalein ingestion on red blood cell resistance to hemolysisPigment metabolism and renal failure in acute sulphonamide haemolysis resembling blackwater feverHÆMOLYTIC ANÆMIA DUE TO SULPHAPYRIDINE 1 January 1942Volume 16, Issue 1Page: 152-162KeywordsChildrenDrugsHemolytic anemiaHepatitisHospital medicineResearch laboratories ePublished: 1 December 2008 Issue Published: 1 January 1942 PDF downloadLoading ...