tbuckley/cabot-search huggingface dataset:
Conscription of children in armed conflict
Authors: D G H de Silva
Journal: BMJ (2001)

The history of childhood abuse includes accounts of child murder, abandonment, prostitution, and child labour. Abuse of children in war is a modern issue brought to our attention in Sri Lanka, where civil war has lasted for about 20 years. One of the more distressing aspects has been the conscription of children. Globally, Amnesty International estimates that over 300 000 children under 18 are fighting in armed conflicts, with many under the age of 15.

> They became bored and restless, and developed obsessions about blood, killing, and torture 

Our experience is likely to mirror experience elsewhere. We found evidence in these child soldiers of psychological maltreatment, trauma, and neglect of human rights. Children were often recruited from poorer families already suffering from the war. All underwent indoctrination, aimed to encourage hatred of the enemy.

The children were involved in manual labour, guard duty, frontline fighting, and use …
Some Important Deficiencies in the Development, Validation, and Reporting of a Prediction Model
Authors: Jonathan Alistair Cook, Gary S. Collins
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Aspergillosis in critically ill patients: Results from a large multicenter cohort
Authors: Fabio Taccone, Pierre Bulpa, Anne-Marie Van den Abeele, George Dimopoulos, Jordi Rello, Benoit Misset, José A Paiva, K Vandewoude, Dirk Vogelaers, Stijn Blot
Journal: Intensive Care Medicine (2013)
Prognostic significance of SC101, a monoclonal Antibody against Lewisy/b in breast tumors
Authors: Zahra Madjd, Ian Spendlove, Ian Ellis, Tina Parsons, Lindy G. Durrant
Journal: Cancer Research (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

1538 

Background: Lewisy and Lewisb antigens are complex carbohydrates and over-expressed by breast, lung, colon and ovarian cancers. The SC101 mAb is a unique Lewis y/b binding antibody which binds to native and extended Lewisy and Lewisb haptens and there is no cross reactivity with H type 1 or H type 2, Lewis x or normal blood group antigens. Material and methods: The immunohistochemical detection of Lewisy/b was performed on 660 formalin-fixed, paraffin embedded breast tumours sections using a routine streptavidin-biotin peroxidase technique.Tissue from these patients had previously been included in tissue microarrays. The present specimen comprises a well characterized series of patients with primary operable breast cancer diagnosed between 1987 and 1992 obtained from the Nottingham Tenovus Primary Breast Carcinoma Series. This includes patients 70 years of age or less (mean: 54) with a long term follow up (mean:7 years). Results: 370 out of 660 (56%) of breast carcinomas were considered negative for Lewis y/b expression,17% (110) 0f cases showed a low level of expression ( 75% of positive cells).We found a positive association between histological grade (p<0.001), Nottingham Prognostic Index (p=0.016) and tumour type (p=0.007) and the level of expression of Lewis y/b. Conclusion: The unique epitope recognised by SC101 mAb on Lewis y/b hapten is over-expressed on breast tissue than normal breast. Moreover, our results lead us to conclude that in this large series of invasive breast cancers, low expression of Lewis y/b was more often found in low grade, good prognosis tumours compared to bad prognosis cancers.
The β‐adrenoceptor agonist isoproterenol rescues acetaminophen‐injured livers: Is it really safe?
Authors: Zhuolin Zou, Zhonghai Shen, Yijing Cai, Yi Chen, Si Chen, Yongping Chen
Journal: Hepatology (2014)

Potential conflict of interest: Nothing to report. To the Editor: We read with great interest the article by Soeda et al.,1 who reported that the sympathetic nervous system (SNS) agonist, isoproterenol, can result in expansion of the hepatic progenitor cell (HPC) population and can ameliorate acetaminophen (APAP)‐induced acute liver injury through the Wnt pathway, thus implicating isoproterenol as a putative novel therapeutic approach for APAP‐induced hepatotoxicity. However, there are alternative explanations based on published findings. First, in dopamine β‐hydroxylase‐deficient (Dbh−/−) mice, there were more ß‐adrenergic receptors in the state of high affinity than in the wild‐type mice.2 After treatment with isoproterenol, the SNS could exert greater effects that could lead to myocardial injury3 and hyperglycemia.4 Evidence indicates that myocardial injury could also result in liver injury,5 and hepatic oxidative stress induced by acute hyperglycemia could aggravate liver damage to some extent.6 These could be factors in an increase in HPC numbers. Hence, the expansion of HPCs in Dbh−/− mice in this experiment may be a result of the indirect effects of isoproterenol‐induced liver injury. Do the researchers have any data concerning the isoproterenol‐induced liver injury in Dbh−/− mice? Second, isoproterenol could lead to cardiotoxicity, dyslipidemia,7 and vascular oxidative stress and endothelial dysfunction,8 which could be a second mechanism by which the liver is damaged. Is it really safe to consider administration of isoproterenol? Do the researchers have any data about the long‐term consequences of isoproterenol therapy?
Chondrocyte β‐Catenin Signaling Regulates Postnatal Bone Remodeling Through Modulation of Osteoclast Formation in a Murine Model
Authors: Baoli Wang, Hongting Jin, Mei Zhu, Jia Li, Lan Zhao, Yejia Zhang, Dezhi Tang, Guozhi Xiao, Lianping Xing, Brendan F. Boyce, Di Chen
Journal: Arthritis & Rheumatology (2013)

Objective To investigate whether β‐catenin signaling in chondrocytes regulates osteoclastogenesis, thereby contributing to postnatal bone growth and bone remodeling. Methods Mice with conditional knockout (cKO) or conditional activation (cAct) of chondrocyte‐specific β‐ catenin were generated. Changes in bone mass, osteoclast numbers, and osteoblast activity were examined. The mechanisms by which β‐catenin signaling in chondrocytes regulates osteoclast formation were determined. Results The β‐ catenin cKO mice developed localized bone loss, whereas cAct mice developed a high bone mass phenotype. Histologic findings suggested that these phenotypes were caused primarily by impaired osteoclast formation, rather than impaired bone formation. Further molecular signaling analyses revealed that β‐catenin signaling controlled this process by regulating the expression of the RANKL and osteoprotegerin (OPG) genes in chondrocytes. Activation of β‐catenin signaling in chondrocytes suppressed Rankl gene transcription through a glucocorticoid receptor–dependent mechanism. The severe bone loss phenotype observed in β‐ catenin cKO mice was largely restored by treatment with human recombinant OPG or transgenic overexpression of Opg in chondrocytes. Conclusion β‐catenin signaling in chondrocytes plays a key role in postnatal bone growth and bone remodeling through its regulation of osteoclast formation.
Syllabus of Human Neoplasms
Authors: R. M. Mulligan
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association between smoking and pulmonary tuberculosis
Authors: Eya Tangour, Jihen Ben Amar, Besma Dhahri, Haifa Zaibi, Mohamed Ali Baccar, Saloua Azzabi, Hichem Aouina, Leila El Gharbi, Hend Bouacha
Journal: European Respiratory Journal (2012)

Background:  Tobacco smoking and tuberculosis (TB) are two major public health problems. It has long been suggested that tobacco smoking may affect rates of TB morbidity and mortality.   Methods:  To assess the clinical features of tuberculosis in smoker9s patients, we report a comparative study between two groups of 41 patients each with active pulmonary tuberculosis. Mean age in smokers group was 40, 4 ± 15, 7 years vs 40, 19 ±13, 6 years in non smoker9s group. 39 of smokers were men with tobacco intoxication about 33, 7 ± 27, 62 Package per year. In no smoker9s group, there were 21 men and 20 women. Symptoms were no specific in both groups and dominated by cough (80% vs 66%), hemoptysis (19, 5% vs 6%) and chest pain (15% vs 20%). Radiological investigations showed bilateral lesions in 21 cases (51, 2%) versus 10 cases (24%). Nodular infiltration was showed in 22 versus 14 cases, consolidation in 10 versus 3 cases, a mass lesion in 1 case in smoker9s group and cavitary lesions in 8 versus 13 cases. The confirmation of tuberculosis was bacteriogical in 37 cases and histological in the others in smoker9s group. It was bacteriological in all patients in non smoker9s group. Smoking patients presented severe adverse event with antituberculosis treatment. This was not reported in controls. A delay of recovery (time between symptoms and recovery) was longer in smokers than in non smokers patients. Pulmonary sequels such as dyspnea and fibrosis were most frequent in smokers.   Conclusion:  Tobacco may delay the recovery of pulmonary tuberculosis and may induce pulmonary sequels in spite of correctly antituberculosis treatment. Therefore smoking prevention and cessation should be a priority in TB prevention program.
740. Replicating Retroviral Vector-Mediated Gene Transfer of the Chemokine, Interferon-Inducible Protein 10 (IP-10) Suppresses Angiogenesis and Tumor Growth in Mice
Authors: Yuansheng Sun, Carsten Finger, Luis Alvarez-Vallina, Klaus Cichutek, Christian J. Buchholz
Journal: Molecular Therapy (2004)

The chemokine interferon-inducible protein 10 (IP-10) is proposed to have antitumor activity in vivo on the basis of its immunomodulatory and antiangiogenic effects. However, the utility of this angiostatic molecule in cancer therapy is hampered by difficulties in manufacturing large quantities of recombinant proteins and the cumbersome administration schedules. This study is aimed to explore IP-10 gene-based anticancer therapy using replicating murine leukemia virus (MLV) vectors, the latter used in order to achieve sustained and efficient delivery of this protein in tumors.
The Spastic Colon
Authors: Harry Gauss
Journal: Annals of Internal Medicine (1930)

Article1 May 1930The Spastic ColonHARRY GAUSS, M.D.HARRY GAUSS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-3-11-1128 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSpastic colon is a functional disturbance of the colon, characterized by hypertonicity or spasticity of the colon, clinically by a variety of symptoms including abdominal consciousness, abdominal pain, constipation, flatulence, and a tendency toward introspection; while inflammatory changes may or may not be present.The term spastic colitis has sometimes been applied to this entity, but objection has been raised to employing a term that signifies an inflammatory state, since the condition is primarily a disturbance in function, while the inflammatory reaction may occur in the course of the disease.The essential mechanism of spastic colon is the hypertonicity. Several...References ALVAREZ WC: Ways in which Emotions can Affect the Digestive System, J. A. M. A., 1922, 92, 1231. CrossrefGoogle Scholar BAYLISSSTARLING WMEH: The Innervation of the Small Intestine, Proc. Physiol. Soc. London, 1898, p. 7. Google Scholar BETTMEN HW: Chronic Appendicitis from the Viewpoint of an Internist, Annals of Internal Medicine, 1928, 2, 509. LinkGoogle Scholar CANNON WB: The Importance of Tonus for the Movements of the Alimentary Canal. Arch. Int. Med., 1911, 8, 417. CrossrefGoogle Scholar DAWSON L: The Colon and Colitis. British Med. Jour. 1921, 2, 31. CrossrefMedlineGoogle Scholar EGGLESTON EL: Colitis, The Spastic Type. J. A. M. A. 1928, 91, 2049. CrossrefGoogle Scholar GASKELL WH: The Involuntary Nervous System. Longmans, Green, and Co., London, 1920. Google Scholar GAUSS H,: The Redundant Colon. Arch. Surg. 1927, 15, 560. CrossrefGoogle Scholar JACOBSON E: Reduction of Nervous Irritability and Excitement by Progressive Relaxation. Trans. Sect. Nerv. and Mental Dis., Am. Med. Assn. 1920. CrossrefGoogle Scholar JORDONKIEFER SMED: The Irritable Colon, J. A. M. A. 1929, 93, 592. CrossrefGoogle Scholar KUNTZ A: The Autonomic Nervous System, Lea and Febiger, Phila. 1929. Google Scholar LEBENSOHN JE: Oculovisceral Reflexes. Am. Jour. Ophthal. 1929, 12, 562. CrossrefGoogle Scholar RANSON SW: Afferent Paths for Visceral Reflexes. Physiol. Reviews, 1921, 1, 477. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine University of Colorado Denver*Read before the Medical Society of the City and County of Denver Feb. 18, 1930. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Krankheiten des DarmesPresent trends in mucous colitisDie Krankheiten des DarmesDie Krankheiten des Darmes 1 May 1930Volume 3, Issue 11Page: 1128-1139KeywordsAbdominal painColitisColonConsciousnessConstipationHypertonicity Issue Published: 1 May 1930 PDF downloadLoading ...
Abstract #LB-264: Prognosis-driven drug discovery in NSCLC adenocarcinoma: High throughput screening for compounds that inhibit the epithelial-to-mesenchymal inducer Zeb1 or the metastases-inducer AGR2
Authors: Michael Mitas, Danielle Timmons, David Rimm, Lynn Tanoue, Arun Gopinath, Andras Khoor, Gerard Silvestri, Carolyn Reed, Elizabeth Garrett-Mayer, Michael Wallace, Harry Drabkin, Robert Gemmill
Journal: Cancer Research (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

Twenty-five to fifty per cent of early stage NSCLC patients who are treated by surgery alone will not survive beyond five years, suggesting a need for better prognostic factors. Using a novel bioinformatics approach, we identified 13 potentially prognostic NSCLC genes in which the expression levels of nine (69%) were highly inversely correlated in the NCI60 CGAP database with the epithelial-to-mesenchymal (EMT) inducers Zeb1 or Zeb2 (R values = 0.57-0.78; p-values  30K). To search for small molecules that might inhibit Zeb1, we constructed a CDH1 luciferase reporter containing a putative Zeb1 high-affinity binding site. Using transfected HEK293 cells, we screened 12,000 compounds from the ChemBridge library. One candidate stimulated endogenous Map7 expression 2.2-fold in HEK293 cells and 49-fold in lung cancer A549 cells. We are also screening the library for compounds that preferentially inhibit AGR2 expression with the goal of identifying novel agents for the treatment of lung cancer.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr LB-264.
Reduction of Mortality From Respiratory Distress Syndrome of Prematurity With Early Administration of Intravenous Glucose and Sodium Bicarbonate
Authors: R USHER
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mirror, mirror on the wall…how photodamaged am I?
Authors: C. Harland
Journal: British Journal of Dermatology (2011)

Journal Article Mirror, mirror on the wall…how photodamaged am I? Get access C. Harland C. Harland Department of Dermatology, Epsom and St Helier University Hospitals, Carshalton SM5 1AA, U.K. E‐mail: christopher.harland@esth.nhs.uk Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 165, Issue 4, 1 October 2011, Page 707, https://doi.org/10.1111/j.1365-2133.2011.10548.x Published: 01 October 2011
Schizophrenia and the Chinese Famine of 1959-1961—Reply
Authors: Richard Neugebauer
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Airline Drinking Water Tainted
Authors: Tracy Hampton
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
My Tomography Report
Authors: John L. Wright
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal