Inappropriate Antidiuresis During Carbamazepine Treatment
Authors: K.M. FLEGEL
Journal: Annals of Internal Medicine (1977)

Brief Reports1 December 1977Inappropriate Antidiuresis During Carbamazepine TreatmentK.M. FLEGEL, M.D., C.M., C.H. COLE, M.D.K.M. FLEGEL, M.D., C.M.Search for more papers by this author, C.H. COLE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-6-722 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA side effect of carbamazepine therapy that might be anticipated from its antidiuretic action in neurohypophyseal diabetes insipidus (1) is water intoxication with hyponatremia. Three such cases, including one patient who developed pulmonary edema on rechallenge, have been reported (2). Our patient developed pulmonary edema followed by inappropriate antidiuresis during treatment with carbamazepine. Asymptomatic hypothyroidism remained untreated during the time we observed water intoxication.A 76-year-old man first experienced in 1961 pain of trigeminal neuralgia in the distribution of the right first and second branches, triggered by biting, chewing, or shaving and associated with tearing in the right eye. Serum...References1. WALES J: Treatment of diabetes insipidus with carbamazepine. Lancet 2:948-951, 1975 CrossrefMedlineGoogle Scholar2. STEPHENSESPIRTATTERSALLQUINNGLADWELLGALBRAITHREYNOLDS WMRNSAE: Water intoxication due to carbamazepine. Br Med J 1:754-755, 1977 CrossrefMedlineGoogle Scholar3. DERUBERTISMICHELISBLOOMMINTZFIELDDAVIS FMMDJB: Impaired water excretion in myxedema. Am J Med 51:41-53, 1971 CrossrefMedlineGoogle Scholar4. KIMURAMATSUISATOYOSHINAGA TKTK: Mechanism of carbamazepine (Tegretol)-induced antidiuresis: evidence for release of antidiuretic hormone and impaired excretion of a water load. J Clin Endocrinol Metab 38:356-362, 1974 CrossrefMedlineGoogle Scholar5. MEINDERSCEJKAROBERTSON AVG: The antidiuretic action of carbamazepine in man. Clin Sci Mol Med 47:289-299, 1974 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nephrology Division Royal Victoria Hospital Montreal, PQ H3A 1A1, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByPolypharmacotherapy and blood products as risk factors for venous thromboembolism in postsurgical patients: a case–control studyPatient With Severe Hyponatremia Caused by Adrenal Insufficiency Due to Ectopic Posterior Pituitary Lobe and Miscommunication Between Hypothalamus and PituitaryDisorders of Sodium and Water BalanceHyponatremia Induced by DrugsA Review of Drug-Induced HyponatremiaThe age and dose-related hyponatremia during carbamazepine and oxcarbazepine therapy in epileptic childrenPsychogenic polydipsia review: Etiology, differential, and treatmentOral and Craniofacial Pain: Diagnosis, Pathophysiology, and TreatmentMedikamentöse Therapie von TumorschmerzenThe medical and surgical management of trigeminal neuralgiaReview of carbamazepine-induced hyponatremiaHyponatremia Associated with Carbamazepine and Oxcarbazepine Therapy: A ReviewImpaired Water Homeostasis following Mixed Carbamazepine and Phenobarbital OverdoseHypersensitivity to Carbamazepine Mimicking InfectionClinical Pharmacology of Drugs Used to Treat Head and Face PainTrigeminal Neuralgia and Related DisordersToxische NierenschädenSIADH: A Serious Side Effect of Psychotropic DrugsTag-Nacht-Rhythmen von Neurohormonen bei epileptischen Kindern vor und unter CarbamazepinmonotherapieIncrease in white blood cell count and serum sodium level following the addition of lithium to carbamazephine treatment among three chronically psychotic male patients with disturbed affective statesImipramine-Induced Syndrome of Inappropriate Antidiuretic Hormone SecretionCarbamazepine and Serum Sodium LevelsHyponatremia due to antidepressant medicationsGranulomatous hepatitis associated with carbamazepine therapyCongestive heart failure during carbamazepine therapyA Case Report and Review of the LiteratureDiagnosis of Hypotonic StatesPETER U. FEIG, M.D., RICHARD H. STERNS, M.D. 1 December 1977Volume 87, Issue 6Page: 722-723KeywordsEdemaHyponatremiaHypothyroidismIntoxication Issue Published: 1 December 1977 PDF DownloadLoading ...