tbuckley/cabot-search huggingface dataset:
Modernising the NHS: Practical partnerships for health and local authorities
Authors: D. Plamping
Journal: BMJ (2000)

This is the last in a series of seven articles 

Partnership has become a legal, almost moral, imperative in the health and social care world in recent years. In policy document after policy document the analysis is consistent and welcome. We need to find new ways of working: “The strategic agenda is to work across boundaries … underpinned by a duty of partnership … past efforts to tackle these problems have shown that concentrating on single elements of the way services work together … without looking at the system as a whole does not work.” 1

The result has been an explosion of partnership boards and partnership meetings throughout Britain—and now there is talk of partnership fatigue. This fatigue is mostly due to a proliferation of structures and plans. Yet frustration with talking about partnership should not be mistaken for rejection of the underlying principle. But now is the time to ask some hard questions. When is partnership effective? What sorts of partnerships are fit for what circumstances?

#### Summary points

A sense of fatigue and frustration with partnerships shouldn't obscure the fact that they are necessary and can be powerful ways of changing whole services for patients and clients

Some partnerships depend on identifying a shared goal: focusing on the needs of patients helps to do this

Organisations may achieve much with less demanding forms of cooperation—and also help to build the trust necessary for proper partnerships

Different organisations need to find a shared “currency” for successful partnership: beds and money often aren't appropriate currencies

The first need therefore is to understand that there are different sorts of partnerships. Studies of public sector partnerships have shown various sorts of partnerships, each effective in different conditions.2 3 This research describes a range of behaviours that organisations may usefully employ when working together …
THE VALUE OF CERTAIN DIAGNOSTIC PROCEDURES IN BRONCHOPNEUMONIA: A CLINICAL STUDY
Authors: John V. Fopeano
Journal: Annals of Internal Medicine (1936)

Article1 September 1936THE VALUE OF CERTAIN DIAGNOSTIC PROCEDURES IN BRONCHOPNEUMONIA: A CLINICAL STUDYJOHN V. FOPEANO, A.B., M.D.JOHN V. FOPEANO, A.B., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-3-379 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn a day when clinicians depend much upon the clinical laboratory for guidance in diagnosis and prognosis, there is a need for data showing the limitations of the objective methods of the laboratory. Even the reliable clinical thermometer may sometimes lead one astray.In a study of the cases of pneumonia which have occurred during the past two years among students at the University of Michigan, three things have stood out clearly:1. Absence of leukocytosis in uncomplicated bronchopneumonia indicates neither a good nor a bad prognosis.2. It is possible and not uncommon to have bronchopneumonia without any detected... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication December 14, 1935.University of Michigan Health Service. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1936Volume 10, Issue 3Page: 379-385KeywordsClinical laboratoriesLeukocytosisMedical servicesPneumoniaResearch laboratoriesThermometers ePublished: 1 December 2008 Issue Published: 1 September 1936 PDF downloadLoading ...
MENIERE'S DISEASE: OTOLOGIC CONCEPT AND DIAGNOSIS
Authors: W H SAUNDERS
Journal: Annals of Internal Medicine (1957)

Article1 July 1957MENIERE'S DISEASE: OTOLOGIC CONCEPT AND DIAGNOSISWILLIAM H. SAUNDERS, M.D.WILLIAM H. SAUNDERS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-47-1-92 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1861 Prosper Meniere1 described a triad of symptoms consisting of recurrent attacks of severe vertigo, persistent tinnitus, and deafness in one ear. He attempted to distinguish between the disease causing this triad and other disorders causing somewhat similar symptoms. Meniere died one year after the publication of his paper. His original clear description was misquoted and erroneously translated. The result is that most physicians after him have understood the disease he described less well than Meniere did.In recent years, interest in Meniere's disease has heightened. The diagnosis has been clarified by study of pathologic material and the development...Bibliography1. Meniere P: Memoire sur des lesions de l'oreille interne donnant lieu a des symptomes de congestion cerebrale apoplectiforme, Gaz. méd. de Paris 16: 597-601, 1861. Google Scholar2. Williams HL: The medical treatment of Meniere's disease, Arch. Otolaryng. 62: 573-578, 1955. CrossrefGoogle Scholar3. Williams HL: Meniere's disease, 1952, Charles C. Thomas, Springfield, Illinois. Google Scholar4. HallpikeCaims CSH: Observations on the pathology of Meniere's syndrome, J. Laryng. and Otol. 53: 625-654, 1938. CrossrefGoogle Scholar5. WeverBrayLawrence ECCWM: The nature of cochlear activity after death, Ann. Otol., Rhin. and Laryng. 50: 317-329, 1941. CrossrefGoogle Scholar6. Furstenberg AC: Anatomical considerations of Meniere's disease, Ann. Otol., Rhin. and Laryng. 61: 692-698, 1952. CrossrefGoogle Scholar7. Hoople GD: Practical aspects of labyrinthine tests, Laryngoscope 59: 12-21, 1949. CrossrefMedlineGoogle Scholar8. Cawthorne T: Positional nystagmus, Ann. Otol., Rhin. and Laryng. 63: 481-490, 1954. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbus, Ohio*Received for publication December 10, 1956.Requests for reprints should be addressed to William H. Saunders, M.D., Associate Professor of Otolaryngology, The Ohio State University Medical Center, Columbus 10, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1957Volume 47, Issue 1Page: 92-107KeywordsDeafnessHypertensionNauseaTinnitusVertigo ePublished: 1 December 2008 Issue Published: 1 July 1957 PDF downloadLoading ...
A Randomized, Multicenter, Single-Blinded Trial Comparing Paclitaxel-Coated Balloon Angioplasty With Plain Balloon Angioplasty in Drug-Eluting Stent Restenosis
Authors: Harald Rittger, Johannes Brachmann, Anil-M. Sinha, Matthias Waliszewski, Marc Ohlow, Andreas Brugger, Holger Thiele, Ralf Birkemeyer, Volkhard Kurowski, Ole-A. Breithardt, Martin Schmidt, Stefan Zimmermann, Sandra Lonke, Moritz von Cranach, The-Vinh Nguyen, Werner G. Daniel, Jochen Wöhrle
Journal: Journal of the American College of Cardiology (2012)
Towards an ethos of interdisciplinary practice
Authors: M. Nolan
Journal: BMJ (1995)

Anyone browsing through the nursing journals over the past few months will have noticed that the profession seems to be undergoing sustained and quite unprecedented change. While change characterises the health care environment in general, several factors seem to have impinged on nursing and exacerbated an already fraught situation.

On the one hand there are dire warnings of the potential impact of “multiskilling,” whereby unqualified and minimally trained personnel are undertaking activities previously deemed to be the province of nurses. Indeed in the United States such workers seem to be already moving into quasi-medical territory and are suturing wounds, injecting intravenous drugs, and inserting catheters.1 Paradoxically, in Britain there are concurrent accounts of the potential benefits, particularly for junior doctors, of nurse practitioners completing a similar range of tasks.2

Although some experts feel that the development of the nurse practitioner will also benefit nursing, there are those who argue that such an initiative is of questionable value and does little but reinforce the traditional “handmaiden” relationship, with the nurse now cast in the role of “technical functionary.”3 In considering alternatives, others assert that nursing's future lies outside acute care, in such domains as health promotion, which is seen to offer “truly infinite scope” for professional growth and development.4

Against this backcloth Castledine suggested that nursing is currently in the throes of an identity crisis, initiated and sustained by the scale and pace of technological, economic, and scientific change in the NHS.5 To consider the likely impact of such factors on the delivery of health and social care and the role of the nurse in …
European guidelines for quality assurance in colorectal cancer screening and diagnosis: Overview and introduction to the full Supplement publication
Authors: L. Von Karsa, J. Patnick, N. Segnan, W. Atkin, S. Halloran, I. Lansdorp-Vogelaar, N. Malila, S. Minozzi, S. Moss, P. Quirke, R. J. Steele, M. Vieth, L. Aabakken, L. Altenhofen, R. Ancelle-Park, N. Antoljak, A. Anttila, P. Armaroli, S. Arrossi, J. Austoker, R. Banzi, C. Bellisario, J. Blom, H. Brenner, M. Bretthauer, M. Camargo Cancela, G. Costamagna, J. Cuzick, M. Dai, J. Daniel, E. Dekker, N. Delicata, S. Ducarroz, H. Erfkamp, J. A. Espinàs, J. Faivre, L. Faulds Wood, A. Flugelman, S. Frkovic-Grazio, B. Geller, L. Giordano, G. Grazzini, J. Green, C. Hamashima, C. Herrmann, P. Hewitson, G. Hoff, I. Holten, R. Jover, M. F. Kaminski, E. J. Kuipers, J. Kurtinaitis, R. Lambert, G. Launoy, W. Lee, R. Leicester, M. Leja, D. Lieberman, T. Lignini, E. Lucas, E. Lynge, S. Mádai, J. Marinho, J. Maučec Zakotnik, G. Minoli, C. Monk, A. Morais, R. Muwonge, M. Nadel, L. Neamtiu, M. Peris Tuser, Michael P Pignone, C. Pox, M. Primic-Zakelj, J. Psaila, L. Rabeneck, David F Ransohoff, M. Rasmussen, J. Regula, J. Ren, G. Rennert, J. Rey, R. H. Riddell, M. Risio, V. Rodrigues, H. Saito, C. Sauvaget, A. Scharpantgen, W. Schmiegel, C. Senore, M. Siddiqi, D. Sighoko, R. Smith, S. Smith, S. Suchanek, E. Suonio, W. Tong, S. Törnberg, E. Van Cutsem, L. Vignatelli, P. Villain, L. Voti, H. Watanabe, J. Watson, S. Winawer, G. Young, V. Zaksas, M. Zappa, R. Valori
Journal: Endoscopy (2012)

Population-based screening for early detection and treatment of colorectal cancer (CRC) and precursor lesions, using evidence-based methods, can be effective in populations with a significant burden of the disease provided the services are of high quality. Multidisciplinary, evidence-based guidelines for quality assurance in CRC screening and diagnosis have been developed by experts in a project co-financed by the European Union. The 450-page guidelines were published in book format by the European Commission in 2010. They include 10 chapters and over 250 recommendations, individually graded according to the strength of the recommendation and the supporting evidence. Adoption of the recommendations can improve and maintain the quality and effectiveness of an entire screening process, including identification and invitation of the target population, diagnosis and management of the disease and appropriate surveillance in people with detected lesions. To make the principles, recommendations and standards in the guidelines known to a wider professional and scientific community and to facilitate their use in the scientific literature, the original content is presented in journal format in an open-access Supplement of <i>Endoscopy.</i> The editors have prepared the present overview to inform readers of the comprehensive scope and content of the guidelines.
Pediatricians Alerted to Five New Vaccines
Authors: T Jefferson
Journal: JAMA (1999)

CHICAGO—Five diseases and the vaccines designed to protect children against them underwent scrutiny at the spring meeting of the American Academy of Pediatrics (AAP) here. Michael A. Gerber, MD, of the National Institute of Allergy and InfectiousDiseases, and JonS.Abramson,MD, of Wake Forest University School of Medicine, presented updates on vaccines against varicella, Lyme disease, influenza, rotavirus, and group A streptococcus.Theefficacyandcost-effectiveness of the first four vaccines varies greatly; the fifth is still in development.
Abstract 16873: Circulating Multimarker Profile of Patients with Symptomatic Heart Failure Demonstrates Enhanced Fibrotic Degradation and Reduced Extracellular Matrix Remodeling
Authors: Kevin J Morine, Vikram Paruchuri, Xiaoying Qiao, Najwa N Mohammad, Adam McGraw, Adil Yunis, Iris Z Jaffe, Navin K Kapur
Journal: Circulation (2014)

Introduction:  Maladaptive cardiac remodeling involves dysregulated angiogenesis and progressive myocardial fibrosis. Recent evidence suggests potential crosstalk between angiogenic and fibrotic signaling pathways in heart failure. Few studies have simultaneously examined circulating markers of angiogenesis and fibrosis in patients with cardiomyopathy.   Hypothesis:  Our hypothesis was that biomarkers of angiogenesis and fibrosis correlate with heart failure severity.   Methods:  Blood samples were collected prospectively from 52 consecutive patients with cardiomyopathy (CM); 17 ischemic (iCM) and 35 non-ischemic (niCM); referred for diagnostic cardiac catheterization. 19 patients without cardiovascular risk factors served as controls. We measured serum levels of markers of collagen synthesis [procollagen type I C-peptide (PIP), procollagen type III C-peptide (P3NP)], collagen degradation [carboxyterminal telopeptide of type I collagen (ICTP)], pro-angiogenesis [placental growth factor (PIGF), vascular endothelial growth factor (VEGF)], anti-angiogenesis [soluble Fms-Like Tyrosine Kinase 1 (sFlt1)], extracellular matrix remodeling [matrix metalloprotease-2 (MMP2), matrix metalloprotease-9 (MMP9), tissue inhibitor of matrix metalloprotease-1 (TIMP-1)], aldosterone and transforming growth factor beta 1 (TGFB). Group means were compared by unpaired student’s T test and correlations between markers were assessed by unweighted Spearman coefficients.   Results:  Among all 52 CM patients compared to controls, P3NP, ICTP, MMP2, TIMP-1, PIGF and sFlt1 were elevated. The PIP/ICTP, PIGF/sFlt1, and VEGF/sFlt1 ratios were reduced among all CM patients consistent with fibrotic degradation and anti-angiogenesis. Compared to iCM, patients with niCM had lower levels of ICTP, MMP2, MMP9, and PIGF. The PIP/ICTP, MMP-9/TIMP-1 and VEGF/sFlt1 ratios were lower in patients with NYHA class III/IV HF compared to class I/II HF.   Conclusions:  In patients with symptomatic heart failure, the circulating biomarker profile is consistent with fibrotic degradation and minimal angiogenesis. Further validation of a multimarker approach in a larger patient cohort may guide patient selection for therapies targeted at fibrosis and angiogenesis.
Social policy and devolution
Authors: A. M Pollock
Journal: BMJ (2001)

The Scottish Executive's dramatic decision last month not to charge elderly people for personal and social care,1 in contrast to the decision of the United Kingdom's Westminster government, has created policy inconsistencies within the UK. Having gained cross party support for its motion to recognise the “'benefits in providing free personal care for the elderly” and “do report by August 2001 its proposals for doing so,”2 the Scottish parliament has now convened the Scottish care development group “po consider the inter-relationship with UK matters, notably the tax and social security benefits system and cross border movement.”3 This decision, together with the plan to abolish student fees at Scottish universities, will test the meaning of devolution, but also raises wider questions about government spending in the UK.

Sutherland has estimated the extra cost in Scotland of implementing free personal care at around £25m ($37.5m).4 But the UK government's rejection of the recommendations of the Royal Commission on Long Term Care5 that personal care should be paid for …
INFLUENTIAL FACTORS IN RECOVERY FROM RHEUMATOID ARTHRITIS
Authors: Russell L. Cecil
Journal: Annals of Internal Medicine (1934)

Article1 September 1934INFLUENTIAL FACTORS IN RECOVERY FROM RHEUMATOID ARTHRITISRUSSELL L. CECIL, M.D., F.A.C.P.RUSSELL L. CECIL, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-8-3-315 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEvery physician knows that there is more than one factor which enters into recovery from an infectious disease. These various factors are constitutional or environmental. It occurred to me that it might be interesting to consider at this time the more important factors which influence recovery in one of our commoner infections, namely rheumatoid arthritis. At the outset some may object to the assumption that rheumatoid arthritis is a chronic infection. It must be admitted that the evidence for its infectious nature is not complete, but the fact remains that the majority of investigators in this field now consider it...References1. MARINESCOALLENDE GG: Sur une forme nouvelle de rhumatisme chronique fibreux, rhumatisme chronique, familial et infantile, Presse méd., 1932, xl, 646-649. Google Scholar2. CECILARCHER RLBH: Chronic infectious arthritis; analysis of 200 cases, Am. Jr. Med. Sci., 1927, clxxiii, 258-270. Google Scholar3. PEMBERTON R: Arthritis and rheumatoid conditions, 1929, Lea and Febiger, Philadelphia. Google Scholar4. DAWSON MH: Comparative study of subcutaneous nodules in rheumatic fever and rheumatoid arthritis, Jr. Exper. Med., 1933, lvii, 845-858. CrossrefGoogle Scholar5. MINOT G: By personal communication. Google Scholar6. BAUERVOGL JA: Psoriasis und Gelenkleiden, Klin. Wchnschr., 1931, x, 1700-1705. CrossrefGoogle Scholar7. PEMBERTONFOSTER RGL: Studies on arthritis in Army, based on 400 cases, Arch. Int. Med., 1920, xxv, 243. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Read at the Chicago meeting of the American College of Physicians, April 19, 1934. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGouty arthritis masquerading as rheumatoid arthritis or vice versaInhibition of adjuvant-induced arthritis in the hyperuricemic ratAnkylosing Spondylitis, Hyperuricemia, and Anomalies of the Lumbosacral Junction A Family StudyGEORGE R. THOMPSON, M.D., WILLIAM MARTEL, M.D., MILOVAN T. RAKIC, M.D., JOHN T. HAYES, M.D.The Course of Rheumatoid Arthritis in Patients Receiving Simple Medical and Orthopedic MeasuresThe Advantages of Hepatic Injury and Jaundice in Certain Conditions, Notably the Rheumatic Diseases 1 September 1934Volume 8, Issue 3Page: 315-326KeywordsInfectious diseasesRheumatoid arthritis ePublished: 1 December 2008 Issue Published: 1 September 1934 PDF downloadLoading ...
Longer-lasting Osteoporosis Drugs Sought
Authors: Bridget M Kuehn
Journal: JAMA (2005)

carbonated beverages can reduce bone mass later in life. Recent studies have suggested that in older patients, vitamin D3 supplements are more effective than vitamin D2 supplements, and that 700 to 800 IU/d of D3 is optimal, noted Bess Dawson-Hughes, MD, chief of the calcium and bone metabolism laboratory at Tufts University. Scientists are also starting to tease out the types of exercise that are most beneficial to bone health. Weight-bearing exercise is key to maintaining bone mass and high-impact exercise such as jumping is necessary to increase bone mass, said Kathy Shipp, PT, PhD, an osteoporosis specialist and assistant professor at Duke University Medical Center in Durham, NC. There also may be certain types of bone stressors that are important to bone health that have not yet been identified. Some scientists are examining the effectiveness of vibration in maintaining bone health. Two recent studies suggest that vibration may have potential for maintaining bone health in children with low mobility and in older women (Ward et al. J Bone Miner Res. 2004;19:360-369 and Verschueren et al. J Bone Miner Res. 2004;19:352-359). The explosion of information about osteoporosis is expected to continue. As with any burgeoning field, however, translating the latest information into a standard of care provided by the key players—internists, family physicians, and gynecologists—will take time, Siris said.
Abstract 2712: ISC-4, a novel inhibitor of hedgehog-Gli signaling, inhibits growth of CSC and CTC of melanoma patients
Authors: Arun K. Sharma, Jitesh Jani, Cristian Sharma, Patrick Cleary, Michael Sharma, Shruthi Satish, Esteban Gomez, Michael Prez, Natalee Amezcua, Mariam Navel, Deepkamal N. Karelia, Dhimant Desai, Shantu Amin, Jay Sharma
Journal: Cancer Research (2014)

Abstract Melanoma is one of the most aggressive cancers, and its incidence and mortality rate are on rise since no treatment options are available for metastatic disease. Recent evidences from in vitro and in vivo studies have demonstrated that aberrant reactivation of the Sonic Hedgehog (SHH) signaling pathway regulates genes that promote cellular proliferation in various human cancer stem cells (CSC) 36118-45. In melanoma cells, RAS-MEK and AKT signaling has also been shown to regulate the nuclear localization and transcriptional activity of Gli-1. Therefore, the agents that inhibit activation of Gli transcription factors have emerged as promising novel therapeutic drugs for pancreatic cancer. Through extensive structure-activity studies in our laboratory, based on naturally occurring isothiocyanates (ITCs) and their isosteric selenium analogs, we have recently identified phenylbutyl isoselecynate (ISC-4) as a promising agent that significantly retarded melanoma tumor growth without any systemic toxicity. We demonstrate here the effect of ISC-4 on the proliferation of CSC and 36118-45CTC (circulating tumor cell) cells isolated from a melanoma patient. ISC-4 treatments resulted in a dose-dependent inhibition of SHH signaling (SMO, PTCH-1, Gli1, Gli2, and Gli3) and induced significant growth inhibition of CSC and CTC cells. The data demonstrate that Hh signaling regulates proliferation of CSC and CTC of human melanoma and treatment with agents like ISC-4 might be a novel approach to prevent growth and metastasis of human melanoma. Citation Format: Arun K. Sharma, Jitesh Jani, Cristian Sharma, Patrick Cleary, Michael Sharma, Shruthi Satish, Esteban Gomez, Michael Prez, Natalee Amezcua, Mariam Navel, Deepkamal N. Karelia, Dhimant Desai, Shantu Amin, Jay Sharma. ISC-4, a novel inhibitor of hedgehog-Gli signaling, inhibits growth of CSC and CTC of melanoma patients. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2712. doi:10.1158/1538-7445.AM2014-2712