PROBABLE INFECTIOUS MONONUCLEOSIS WITHOUT POSITIVE HETEROPHIL AGGLUTINATION TESTS
Authors: S LEIBOWITZ
Journal: Annals of Internal Medicine (1956)

Article1 April 1956PROBABLE INFECTIOUS MONONUCLEOSIS WITHOUT POSITIVE HETEROPHIL AGGLUTINATION TESTSSIDNEY LEIBOWITZ, M.D., F.A.C.P.SIDNEY LEIBOWITZ, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-4-717 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been the writer's opinion heretofore that all cases of infectious mononucleosis, if properly studied, would reveal positive heterophil agglutination tests. This statement requires some clarification: from the serologic viewpoint a proper study would mean testing for heterophil antibodies at frequent intervals (preferably weekly) for at least three months before the failure to observe a positive test was acceptable. Furthermore, the heterophil agglutination tests should include absorption with guinea pig kidney and beef cell antigens particularly for titers that are, unabsorbed, within the normal range of 1:56 or lower, or within slightly elevated ranges such as 1:112 or 1:224....Bibliography1. Leibowitz S: Infectious mononucleosis: the value of differential absorption tests in its serologic diagnosis, Am. J. Med. 13: 172-182, 1952. CrossrefMedlineGoogle Scholar2. BakstLeibowitz HS: Infectious mononucleosis: first appearance of significant numbers of heterophile antibodies and abnormal lymphocytes ("virocytes") in seventh week of illness. Report of case, Am. J. Med. 13: 235-241, 1952. CrossrefMedlineGoogle Scholar3. Leibowitz S: Infectious mononucleosis, 1953, Grune and Stratton, Inc., New York. Google Scholar4. Leibowitz S: Infectious mononucleosis. Report of a case presenting as acute anaphylactic shock treated with ACTH and cortisone, New York State J. Med. 54: 2711-2716, 1954. 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Miller for the opportunity to observe this patient and to incorporate the data concerning her in this report. 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