UNCONTROLLABLE HEMORRHAGE AFTER DICOUMAROL THERAPY WITH AUTOPSY FINDINGS
Authors: Edmund L. Shlevin, Max Lederer
Journal: Annals of Internal Medicine (1944)

Case Reports1 August 1944UNCONTROLLABLE HEMORRHAGE AFTER DICOUMAROL THERAPY WITH AUTOPSY FINDINGSEDMUND L. SHLEVIN, M.D., MAX LEDERER, M.D.EDMUND L. SHLEVIN, M.D., MAX LEDERER, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-2-332 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInterest in anti-coagulants as therapeutic agents has encouraged the trial of various substances in conditions characterized by intravascular clotting with resultant thrombosis and embolism. During the past few years heparin has occupied a leading rôle in this respect, until the discovery of the part played by spoiled sweet clover in the production of hemorrhagic disease of cattle.1 The recognition of the active principal, dicoumarin (3,3′ Methylenebis [4-Hydroxycoumarin]), its isolation and synthesis by Link and his coworkers,2 have paved the way for its therapeutic employment in man.Most reports thus far in the literature have described the beneficial results from its...Bibliography1. SCHOFIELD FW: Damaged sweet clover: The cause of a new disease in cattle simulating hemorrhagic septicemia and blackleg, Jr. Am. Vet. Med. Assoc., 1924, lxiv, 553-575. Google Scholar2. CAMPBELLROBERTSSMITHLINK HAWLWKKP: Studies on the hemorrhagic sweet clover disease I, Jr. Biol. Chem., 1940, cxxxvi, 47-55. CrossrefGoogle Scholar3. CAMPBELLLINK HAKP: Studies on the hemorrhagic sweet clover disease IV, Jr. Biol. Chem., 1941, cxxxviii, 21-33. CrossrefGoogle Scholar4. CAMPBELLSMITHROBERTSLINK HAWKWLKP: Studies on the hemorrhagic sweet clover disease II, Jr. Biol. Chem., 1941, cxxxviii, 1-20. Google Scholar5. HUEBNERLINK CFKP: Studies on the hemorrhagic sweet clover disease VI, Jr. Biol. Chem., 1941, cxxxviii, 529-534. CrossrefGoogle Scholar6. OVERMANSTAHMANSULLIVANHUEBNERCAMPBELLLINK RSMAWRCFHAKP: Studies on the hemorrhagic sweet clover disease VII, Jr. Biol. Chem., 1942, cxlii, 941-954. CrossrefGoogle Scholar7. STAHMANHUEBNERLINK MACFKP: Studies on the hemorrhagic sweet clover disease V, Jr. Biol. Chem., 1941, cxxxviii, 513-527. CrossrefGoogle Scholar8. BUTTALLENBOLLMAN HREVJL: A preparation from spoiled clover which prolongs coagulation and prothrombin time of the blood—preliminary report of experimental and clinical studies, Proc. Staff Meet. Mayo Clin., 1941, xvi, 388-395. Google Scholar9. LEFEVRE FA: The effect of 3,3′ Methylene-Bis(4-Hydroxycoumarin) Dicoumarol on the prothrombin and coagulation time of the blood, Cleveland Clin. Quart., 1942, ix, 147-152. CrossrefGoogle Scholar10. TOWNSENDMILLS SRES: The effect of the synthetic hemorrhagic agent 3,3′ Methylene-bis(4-Hydroxycoumarin) in prolonging the coagulation and prothrombin time in the human subject, Jr. Canad. Med. Assoc., 1942, xlvi, 214-218. Google Scholar11. PRANDONIWRIGHT AIS: The anti-coagulants heparin and the dicoumarin 3,3′ Methylene-Bis(4-Hydroxycoumarin), Bull. New York Acad. Med., 1942, xviii, 433-455. Google Scholar12. DAVIDSONMACDONALD CSH: Critical study of action of 3,3′ Methylenebis (4-Hydroxycoumarin) dicoumarin, Am. Jr. Med. Sci., 1943, ccv, 24-33. CrossrefGoogle Scholar13. BINGHAMMEYERHOWARD JBOOB: Studies on the hemorrhagic agent 3,3′ Methylenebis(4-Hydroxycoumarin) III, Am. Jr. Med. Sci., 1943, ccv, 587-594. CrossrefGoogle Scholar14. BINGHAMMEYERPOHLE JBOOFJ: Studies on the hemorrhagic agent 3,3′ Methylenebis (4-Hydroxycoumarin) I, Am. Jr. Med. Sci., 1941, ccii, 563-578. CrossrefGoogle Scholar15. MEYERBINGHAMAXELROD OOJBVH: Studies on the hemorrhagic agent 3,3′ Methylenebis (4-Hydroxycoumarin) II, Am. Jr. Med. Sci., 1942, cciv, 11-21. CrossrefGoogle Scholar16. BARKERALLENWAUGH NWEVJM: The use of dicoumarol (3,3′ Methyllenebis) 4-Hydroxycoumarin in the prevention of postoperative thrombophlebitis and pulmonary embolism, Proc. Staff Meet. Mayo Clin., 1943, xviii, 102-107. Google Scholar17. LALICHLALICHCOPLEY JJMHAL: Bleeding time in mice following oral administration of 3,3′ Methylene-bis (4-Hydroxycoumarin), Surgery, 1943, xiii, 316-321. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, New York*Received for publication August 7, 1943.From Departments of Medicine and Laboratories, Jewish Hospital of Brooklyn. 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