Ascorbic Acid Effects on Erythrocytes
Authors: CHARLES E. MENGEL
Journal: Annals of Internal Medicine (1976)

Comments and Corrections1 April 1976Ascorbic Acid Effects on ErythrocytesCHARLES E. MENGEL, M.D., HARRY L. GREENE JR., M.D.CHARLES E. MENGEL, M.D.Search for more papers by this author, HARRY L. GREENE JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-84-4-490_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A recent communication in this journal (1) concerning a patient with G-6-PD deficiency who apparently suffered an episode of hemolysis after the administration of intravenous doses of ascorbic acid prompted us to review the results of a study done in our laboratory a few years ago, but not previously reported.We had been concerned by the use of large quantities of ascorbic acid in some persons. Our studies in mice showed an untoward in-vivo effect of ascorbic acid, or aspirin, or both, on erythrocytes (2). Subsequently, we studied the effect of ingestion of ascorbic acid on erythrocytes...References1. CAMPBELL G, STEINBERG M, and BOWER J: Ascorbic acid-induced hemolysis in G-6-PD deficiency. Ann Intern Med 82:810, 1975 LinkGoogle Scholar2. SERRILL S, JEFFERSON D, and QUICK J: Effect of acetylsalicylic acid and ascorbic acid on oxygen toxicity. Aerosp Med 42:436-438, 1971 MedlineGoogle Scholar3. MENGEL C, KANN H, and MERIWETHER W: Studies of paroxysmal nocturnal hemoglobinuria erythrocytes: increased lysis and lipid peroxide formation by hydrogen peroxide. J Clin Invest 46:1715-1723, 1967 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: CHARLES E. MENGEL, M.D.; HARRY L. GREENEJR., M.D.Affiliations: Department of Medicine University of Missouri School of Medicine Columbia, Missouri 65201 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAscorbic acid (vitamin C)Ascorbic acid (vitamin C)Hazards of Nonprescription MedicationsReduced plasma ascorbic acid and red cell glutathione contents in sickle cell disease—A preliminary reportEffect of iron on polymorphonuclear granulocyte phagocytic capacity: role of oxidation state and effect of ascorbic acidVitamin C-induced erythrocyte damage in premature infantsClinical and Legal Aspects of Nonphysician Prescription of Vitamins, Amino Acids, and Other Nutritional SupplementsVitamin use in clinical medicinePlasma ascorbic acid in adult males: effects of depletion and supplementationVitamin C: The nontoxic, nonrate-limited, antioxidant free radical scavengerReduced levels of plasma ascorbic acid (vitamin C) in sickle cell disease patients: its possible role in the oxidant damage to sickle cells in vivoEffects of dietary vitamin E and high supplementation of vitamin C on plasma glucose and cholesterol levelsAn increase in glutathione peroxidase activity induced by high supplementation of vitamin C in ratsSafety of Megavitamin TherapyDoes consumption of mega-doses of ascorbic acid pose a hemolytic risk to persons with sickle cell trait and sickle cell anemia?High neonatal plasma ascorbic acid levels as a contributing cause of hyperbilirubinemia amongst G-6-PD deficient infantsEvolutionary loss of ascorbic acid synthesis: How it may have enhanced the survival interests of manVitamin Excess and ToxicityAn increase in vitamin E requirement induced by high supplementation of vitamin C in ratsSerum enzyme activities in mice fed a high level of ascorbic acidDrug-Induced Oxidative HaemolysisVitaminsVITAMIN C TOXICITY 1 April 1976Volume 84, Issue 4Page: 490-490KeywordsAspirinIngestionResearch laboratories ePublished: 1 December 2008 Issue Published: 1 April 1976 PDF downloadLoading ...