tbuckley/cabot-search huggingface dataset:
The Rous Sarcoma Virus
Authors: Henry C. Pitot
Journal: JAMA (1983)

Francis Peyton Rous was a pathologist who received his clinical training as a medical student under William Osier at the Johns Hopkins Medical School and his training in pathology with Warthin at the University of Michigan and with Schmorl in Dresden, Germany. Like many physicians of that time, he contracted the occupational disease of pathologists, tuberculosis, first as a medical student during an autopsy; the resultant tuberculous axillary gland was later excised. Following his postgraduate training in pathology, pulmonary tuberculosis developed, which necessitated a period in the New York Adirondack Mountains for recovery. Rous had initially desired to be a botanist or a writer and, in fact, had given evidence of these inclinations during his early teens. After the death of his father, his mother rejected the idea of joining her family in Texas; instead, she chose to stay in Baltimore, where there were excellent educational opportunities for her two
Mudi-chood on the pinnae
Authors: P. SUGATHAN
Journal: British Journal of Dermatology (1976)

Journal Article Mudi‐chood on the pinnae Get access P. SUGATHAN P. SUGATHAN Department of Dermatology and Venereology, Medical College Hospital, Calicut—673008, India Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 95, Issue 2, 1 August 1976, Pages 197–198, https://doi.org/10.1111/j.1365-2133.1976.tb00827.x Published: 01 August 1976
Submandibular Gland Carcinoma With Unusual Widespread Bone Marrow Metastases Detected by Tc-99m MDP Bone Scan and FDG PET
Authors: Hui-Ling Ko, Yuk-Wah Tsang, Yen-Kung Chen, Kwan-Hwa Chi
Journal: Clinical Nuclear Medicine (2007)

We report a case of a 33-year-old woman with undifferentiated submandibular gland carcinoma, status post excision and external radiotherapy. Three years after radiotherapy, primary tumor control was considered to be satisfactory, but she complained of upper back pain. A Tc-99m MDP whole body bone scan was done and exhibited diffuse uptake in the axial skeleton and relatively decreased tracer uptake in the extremities. Positron emission tomography demonstrated increased F-18 FDG uptake over the whole spine and pelvis. Immunohistochemical staining of an iliac crest bone marrow biopsy corresponded to features of submandibular gland tumor cells.
Abnormal lymph drainage in patients with chronic venous leg ulcers
Authors: R.H. Bull, P.S. Mortimer, J. Gane, A.G.A. Joseph
Journal: British Journal of Dermatology (1990)

Journal Article Abnormal lymph drainage in patients with chronic venous leg ulcers Get access R.H. Bull, R.H. Bull Departments of Dermatology, St. George's Hospital, London SW17 Search for other works by this author on: Oxford Academic Google Scholar P.S. Mortimer, P.S. Mortimer Departments of Dermatology, St. George's Hospital, London SW17 Search for other works by this author on: Oxford Academic Google Scholar J. Gane, J. Gane Nuclear Medicine, St. George's Hospital, London SW17 Search for other works by this author on: Oxford Academic Google Scholar A.G.A. Joseph A.G.A. Joseph Nuclear Medicine, St. George's Hospital, London SW17 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 123, Issue s37, 1 July 1990, Page 33, https://doi.org/10.1111/j.1365-2133.1990.tb04435.x Published: 01 July 1990
Oesophageal dysfunction in patients with primary Sjogren's syndrome.
Authors: E B Tsianos, C D Chiras, A A Drosos, H M Moutsopoulos
Journal: Annals of the Rheumatic Diseases (1985)

Oesophageal motility was studied in 22 patients with primary Sjögren's syndrome and 20 normal volunteers. Oesophageal dysfunction was detected in eight of the 22 patients (36.4%) with primary Sjögren's syndrome. No abnormalities were detected in the normal subjects. Individual analysis of the oesophageal motility studies showed different patterns of oesophageal dysfunction; aperistalsis (three patients), triphasic tertiary contractions (two patients), frequent non-peristaltic contractions (two patients), and low contractions (one patient). These oesophageal abnormalities did not correlate with the parotid flow rate, the degree of inflammatory infiltrate of the minor salivary glands, the extraglandular manifestations, or the presence of autoantibodies.
Therapy With Immunoglobulin Suppresses Myocarditis in a Murine Coxsackievirus B3 Model
Authors: Hitoshi Takada, Chiharu Kishimoto, Yuji Hiraoka
Journal: Circulation (1995)

Background The treatment of some inflammatory diseases (eg, Kawasaki disease) with immunoglobulin has been demonstrated to be effective. Accordingly, to elucidate the mechanism underlying such actions of immunoglobulin, we examined its effects on murine coxsackievirus B3 (CB3) myocarditis. Methods and Results An in vitro study showed dose-dependent suppression of CB3 by immunoglobulin. Immunoglobulin 1 g · kg −1 · d −1 IP was administered to CB3-infected C3H/He mice daily for 2 weeks, beginning simultaneously with virus inoculation in experiment 1 and on day 14 after virus inoculation in experiment 2. In both experiments, survival was higher in treated than in control mice; at the time of death, inflammatory cell infiltration and the severity of necrosis and calcification also were reduced. Notably, in experiment 1, immunoglobulin administration completely suppressed the development of myocarditis. Serum-neutralizing antibody titers in the treated mice were significantly higher than those in untreated mice in experiment 1 but not in experiment 2. The circulating antibodies of the treated mice were primarily of exogenous origin in experiment 1 and of exogenous and endogenous origins in experiment 2. The analysis of splenic lymphocyte subsets revealed a marked decrease of the B cell population in the treated mice. Conclusions Immunoglobulin therapy completely suppressed acute CB3 myocarditis by transferring the neutralizing antibody into the host in the acute viremic stage and induced an anti-inflammatory effect in the subsequent aviremic stage; the reduction of the splenic B-cell population may be closely associated with an anti-inflammatory effect.
A Positive Ga-67-citrate Scan in a Patient with Unilateral Absence of Pulmonary Perfusion
Authors: DAVID A. CAUSEY, WILLIAM A. FAJMAN, CARTER DAVIS, PETER J. SONES, YAVUZ A. TARCAN
Journal: Clinical Nuclear Medicine (1980)

CAUSEY, DAVID A. M.D.; FAJMAN, WILLIAM A. M.D.; DAVIS, CARTER M.D.; SONES, PETER J. M.D.; TARCAN, YAVUZ A. M.D. Author Information
The PIQuA Study
Authors: PAUL J. SANAZARO
Journal: Annals of Internal Medicine (1980)

Letters1 February 1980The PIQuA StudyPAUL J. SANAZARO, M.D.PAUL J. SANAZARO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-92-2-267_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In his article "The Medical Record as a Basis for Assessing Physician Competence" (1), Beverly Payne adds new information to the meager store of knowledge on this important subject. He refers to Private Initiative in Quality Assurance(PIQuA), but the necessarily brief allusion does not adequately or correctly describe its major characteristics.PIQuA is sponsored by the American College of Physicians, the American Society of Internal Medicine, and the American Hospital Association. It is funded by the W. K. Kellogg Foundation of Battle Creek, Michigan. The purpose of PIQuA is to determine the feasibility of giving formal recognition...Reference1. PAYNE B. The medical record as a basis for assessing physician competence. Ann Intern Med. 1979;91:623-9. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Private Initiative in Quality Assurance 1221 Broadway, Suite 320, Oakland, CA 94612 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1980Volume 92, Issue 2_Part_1Page: 267-267KeywordsHospital medicine Issue Published: 1 February 1980 PDF downloadLoading ...
In-Shoe Foot Pressure Measurements in Diabetic Patients With At-Risk Feet and in Healthy Subjects
Authors: Marc R Sarnow, Aristidis Veves, John M Giurini, Barry I Rosenblum, James S Chrzan, Geoffrey M Habershaw
Journal: Diabetes Care (1994)

To measure in-shoe foot pressures in diabetic patients and healthy subjects and compare them with the foot pressures when they walked without their shoes.Forty-four diabetic patients at risk of foot ulceration and 65 healthy subjects were matched for age, sex, race, and weight. Neuropathy was evaluated clinically, and the F-Scan program was used to measure the foot pressures. Foot pressures were measured with the sensors placed in the shoes (S measurements), between the foot and the sock with shoes (H measurements) or with their socks alone (B measurements).In the control group, significant differences were found between S (4.77 +/- 1.87 kg/cm2) and H measurements (5.12 +/- 1.87 kg/cm2, P < 0.001), between S and B (7.23 +/- 2.95 kg/cm2, P < 0.0001), and between H and B (P < 0.0001). In the diabetic group, no difference was found between S and H measurements (5.28 +/- 2.22 vs. 5.27 +/- 2.39 kg/cm2, NS). In contrast, the B pressure was significantly higher when compared with both (8.77 +/- 4.67 kg/cm2, P < 0.02). When compared with the control group, the S and H pressures did not differ significantly, but the B pressure in the diabetic group was significantly higher (P < 0.02). The peak S pressure was above the normal limit in 24 (27%) diabetic and 21 (16%) control feet (P < 0.05), the H pressure in 17 (19%) diabetic feet and 22 (17%) control feet (NS), and the B pressure in 24 (27%) diabetic and 21 (16%) control feet (P < 0.05).In-shoe foot pressure measurements are significantly lower than the ones measured when walking with the socks only in both diabetic patients and healthy subjects. The shoes of diabetic patients provided a higher pressure reduction than did those of the control group, but the number of feet with abnormally high pressures did not change. The F-Scan system may be particularly helpful in designing footwear suitable for diabetic patients with at-risk feet.
657 ASSOCIATION WITH HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS X AND CORE PROMOTER MUTATIONS AMONG PATIENTS INFECTED WITH HBV/C2 IN KOREA: A CASE CONTROL STUDY
Authors: J.K. Kim, H.Y. Chang, S.H. Ahn, D.Y. Kim, Y.H. Paik, K.S. Lee, K.H. Han, C.Y. Chon, B.S. Moon, Y.M. Moon
Journal: Journal of Hepatology (2008)
The Harveian Oration on SOME EPOCHS IN MEDICAL RESEARCH
Authors: H. Dale
Journal: BMJ (1935)

Among his many and generous benefactions to the College, which long held a central place in his interest and his devotion, William Harvey, as you know, provided for the delivery of an annual Oration, to commemorate all the benefactors of the College, and " to Exhort the Fellows and Members of the College to search and study out the secrets of Nature by way of Experiment."Harvey thus formally bequeathed to us a great tradition, and took care that we should annually be reminded of its meaning and its claim..A Fellow of this College could receive no higher honour than
Latent Infection of Cells in HIV Disease
Authors: Spyros A. Kalams
Journal: JAMA (1998)

In evaluating current combination drug regimens for treatment of human immunodeficiency virus (HIV) disease, it is important to determine the existence of viral reservoirs. After depletion of CD8 cells from the peripheral blood mononuclear cells (PBMCs) of both patients and normal donors, activation of patient CD4 lymphocytes with immobilized antibodies to CD3 and CD28 enabled the isolation of virus from PBMCs of six patients despite the suppression of their plasma HIV RNA to fewer than 50 copies per milliliter for up to 2 years. Partial sequencing of HIV pol revealed no new drug resistance mutations or discernible evolution, providing evidence for viral latency rather than drug failure.
Preventive effect of long-term aldose reductase inhibition (ponalrestat) on nerve conduction and sural nerve structure in the spontaneously diabetic Bio-Breeding rat.
Authors: A A Sima, A Prashar, W X Zhang, S Chakrabarti, D A Greene
Journal: Journal of Clinical Investigation (1990)

To test the hypothesis that aldose reductase inhibition may prevent or delay the development of functional and structural neuropathy in the insulin-deficient diabetic Bio-Breeding rat (BB-rat), hyperglycemic rats were begun on the aldose reductase inhibitor (ARI) ponalrestat 25 mg/kg body wt soon after the onset of diabetes and followed for 4 or 6 mo. Ponalrestat treatment completely prevented the characteristic nerve conduction slowing and structural abnormalities of the node of Ranvier for 4 mo despite only partial preservation of axonal integrity. Ponalrestat treatment for 6 mo achieved a partial but significant prevention of nerve conduction slowing, axoglial dysjunction, and axonal degenerative changes. This incomplete but significant prevention of neuropathy by ponalrestat suggests that additional mechanisms besides polyol-pathway activation may be of importance in the pathogenesis of diabetic neuropathy. Alternatively, the dosage used in the present study may not have been sufficient to achieve a complete prevention. Despite the only partial protective effect of ARI treatment on degenerative peripheral nerve changes in hyperglycemic BB-rats, 6 mo of treatment resulted in a more than threefold increase in regenerating nerve fibers. These data suggest that prophylactic ARI treatment may be efficacious in delaying the development of diabetic neuropathy.
HIV: From Biology to Prevention and Treatment
Authors: Natasha Bagdasarian
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Rh-Hr syllabus; the types and their applications
Authors: I. Davidsohn
Journal: JAMA (1963)

In this present second edition of this syllabus, Dr. I. B. Wexler, long time associate of the senior author, became co-author. During the 9 years between the first edition and the second edition much that is new has been added to the subject, even more than the 25% increase in size would suggest, yet the topics treated in the eight chapters have remained the same. The points of view expressed are also unchanged; for example, referring to the damage in the brain and liver on page 58, Wiener believes that "the lesions encountered in the erythroblastic infant are due, at least in part, to intravascular conglutination of red cells with blocking of the circulation." This point of view will find few if any supporters. On the other hand, among the innovations there is at least one which could have been omitted profitably: icterus index has been added. Biochemists generally agree
<i>HNF1B</i> Abnormality (Mature-Onset Diabetes of the Young 5) in Children and Adolescents
Authors: Klemens Raile, Eva Klopocki, Theda Wessel, Dorothee Deiss, Denise Horn, Dominik Müller, Reinhard Ullmann, Annette Grüters
Journal: Diabetes Care (2008)

Mature-onset diabetes of the young 5 (MODY5) is characterized by a wide clinical spectrum, including diabetes and kidney disease (1–3). Associated gene defects are either mutations within HNF1B or a 1.4–1.5 Mb monoallelic deletion of chromosome 17q12 including HNF1B (4,5). Up to now, information on prevalence of MODY5 in children and adolescents with diabetes has been very limited (2). We now report prevalence of MODY5 and associated anomalies of HNF1B in a large cohort of children and adolescents with diabetes being followed at our diabetes center.

Analysis of the HNF1B gene was performed by DNA sequencing of all exons (including flanking introns), and samples with normal sequence variants were subsequently analyzed for deletions or duplications using …
Clarification of AIDS Mortality in Women
Authors: Ruth L. Berkelman
Journal: JAMA (1991)

<h3>To the Editor.—</h3> In our recently published study in<i>JAMA</i>,<sup>1</sup>we documented the rapidly increasing effect of human immunodeficiency virus (HIV) infection on mortality in young women. We also noted that 35% of death certificates in women 15 to 44 years of age that indicated HIV infection or the acquired immunodeficiency syndrome (AIDS) also listed specific AIDS-indicator illnesses. These data have been misinterpreted as evidence that only 35% of HIV-infected women who die have an AIDS-defining illness and that the surveillance case definition is less inclusive of women than men. In fact, the number of women who were reported to the Centers for Disease Control with AIDS-defining illness and who died in 1987 exceeds the number of deaths in 1987 in women that were attributed to HIV or AIDS on death certificates (Figure). The misinterpretation may reflect a confusion about the differences between the information available from vital statistics
Endocytosis, intracellular transport, and exocytosis of lanthanide-doped upconverting nanoparticles in single living cells
Authors: Yun Mi Bae, Yong Il Park, Sang Hwan Nam, Jeong Hyun Kim, Kyunghee Lee, Hyung Min Kim, Byeongjun Yoo, Joon Sig Choi, Kang Taek Lee, Taeghwan Hyeon, Yung Doug Suh
Journal: Biomaterials (2012)
FDA Expands Warning on Diet Products
Authors: Rebecca Voelker
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cancer Research — Controversy, Progress and Prospects
Authors: Emil Frei
Journal: New England Journal of Medicine (1975)

IN the March 27 issue of the Journal, Mr. Greenberg presents a sweeping indictment of the National Cancer Program.1 His most specific criticism is that there has been no progress during the past 20 years in treatment (as measured by survival) for types of cancer that represent 78 per cent of the incidence of the disease.Survival of patients with cancer is quantitatively and authoritatively presented elsewhere in this issue by Cutler and his associates of the End Results Section of the National Cancer Institute. To summarize their observations, slow but steady progress has been achieved in types of . . .
Transatrial resection of the obstructed right ventricular infundibulum.
Authors: L H Edmunds, N C Saxena, S Friedman, W J Rashkind, P F Dodd
Journal: Circulation (1976)

Obstructions of the right ventricular infundibulum were resected through the orifice of the tricuspid valve in 21 patients, 15 of whom had tetralogy of Fallot. At operation the systolic pressure difference between the right ventricle and pulmonary artery after repair averaged 18 mm Hg (range 0-40 mm Hg). In patients with tetralogy, cardiac index four hours after operation averaged 2.8 L/M2/min. One patient with tetralogy and severe pulmonary hypertension died. Twelve patients with tetralogy were recatheterized 10 to 186 days after operation. The mean systolic pressure difference between right ventricle and pulmonary artery was 23 mm Hg. Residual obstructions were in the pulmonary valvular annulus. Cineangiograms did not show paradoxical motion of the right ventricular wall. Transatrial resection of right ventricular infundibular obstructions carries with it none of the consequences that often follow right ventriculotomy and this surgical approach satisfactorily relieves infundibular obstructions.
Reasonable Extent of Lymph Node Dissection in Intentional Segmentectomy for Small-Sized Peripheral Non–Small-Cell Lung Cancer: From the Clinicopathological Findings of Patients Who Underwent Lobectomy with Systematic Lymph Node Dissection
Authors: Yuki Matsumura, Tomoyuki Hishida, Junji Yoshida, Keiju Aokage, Genichiro Ishii, Kanji Nagai
Journal: Journal of Thoracic Oncology (2012)
Congenital deficiency of two polypeptide subunits of the iron-protein fragment of mitochondrial complex I.
Authors: R W Moreadith, M W Cleeter, C I Ragan, M L Batshaw, A L Lehninger
Journal: Journal of Clinical Investigation (1987)

Recently, we described a patient with severe lactic acidosis due to congenital complex I (NADH-ubiquinone oxidoreductase) deficiency. We now report further enzymatic and immunological characterizations. Both NADH and ferricyanide titrations of complex I activity (measured as NADH-ferricyanide reductase) were distinctly altered in the mitochondria from the patient's tissues. In addition, antisera against complex I immunoprecipitated NADH-ferricyanide reductase from the control but not the patient's mitochondria. However, immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis of complex I polypeptides demonstrated that the majority of the 25 polypeptides comprising complex I were present in the affected mitochondria. A more detailed analysis using subunit selective antisera against the main polypeptides of the iron-protein fragments of complex I revealed a selective absence of the 75- and 13-kD polypeptides. These findings suggest that the underlying basis for this patient's disease was a congenital deficiency of at least two polypeptides comprising the iron-protein fragment of complex I, which resulted in the inability to correctly assemble a functional enzyme complex.
Differential Responses to Erlotinib in Epidermal Growth Factor Receptor (<i>EGFR</i>)-Mutated Lung Cancers With Acquired Resistance to Gefitinib Carrying the L747S or T790M Secondary Mutations
Authors: Daniel B. Costa, Susan T. Schumer, Daniel G. Tenen, Susumu Kobayashi
Journal: Journal of Clinical Oncology (2008)