Hairy-Cell Leukemia Presenting as Aplastic Anemia
Authors: ROBERT L. BREARLEY
Journal: Annals of Internal Medicine (1979)

Brief Reports1 August 1979Hairy-Cell Leukemia Presenting as Aplastic AnemiaROBERT L. BREARLEY, M.B., RAMONA M. CHAPMAN, M.D., BRANCO BROZOVIC, Ph.D.ROBERT L. BREARLEY, M.B., RAMONA M. CHAPMAN, M.D., BRANCO BROZOVIC, Ph.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-91-2-228 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHairy-cell leukemia typically presents with a reduction in normal peripheral blood cells and variable numbers of circulating mononuclear cells with prominent cytoplasmic projections. The blood changes are usually associated with effacement of bone-marrow architecture by a diffuse mononuclear cell infiltrate and a characteristic pattern of increased delicate fibrosis seen on marrowbiopsy (1-3). During the past 3 years, four patients with hairy-cell leukemia have been referred to our departments with peripheral blood cytopenias but bone-marrow hypoplasia of such degree that they were originally diagnosed as having aplastic anemia. This presentation has not been described previously.Three patients presented with anemia...References1. BOURONCLE B, WISEMAN B, and DOAN C. Leukemic reticuloendotheliosis. Blood. 1958;13:609-30. CrossrefMedlineGoogle Scholar2. GOLOMB H, CATOVSKY D, and GOLDE D. Hairy cell leukemia: a clinical review based on 71 cases. Ann Intern Med. 1978;89:677-83. LinkGoogle Scholar3. BURKE J, BYRNE S, and RAPPAPORT H. Hairy cell leukemia (leukemic reticuloendotheliosis): I. A clinical pathologic study of 21 cases. Cancer. 1974;33:1399-410. CrossrefMedlineGoogle Scholar4. YAM L, LI C, and FINKEL H. Leukemic reticuloendotheliosis: the role of tartrate-resistant acid phosphatase in diagnosis and splenectomy in treatment. Arch Intern Med. 1972;130:248-56. CrossrefMedlineGoogle Scholar5. YAM L, CHAUDHRY A, and JANCKILA A. Impaired marrow granulocyte reserve and leukocyte mobilization in leukemic reticuloendotheliosis. Ann Intern Med. 1977;87:444-6. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT L. BREARLEY, M.B.; RAMONA M. CHAPMAN, M.D.; BRANCO BROZOVIC, Ph.D.Affiliations: St. Bartholomew's Hospital London England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySuccessful Treatment of Aplastic Variant of Hairy-cell Leukaemia with DeoxycoformycinA 43-year-old woman with severe pancytopenia and a splenic hematomaBone Marrow in Hairy Cell LeukemiaHairy cell leukemiaUse of a panel of monoclonal antibodies for the diagnosis of hairy cell leukaemia. An immunocytochemical study of 36 casesHairy cell leukemia. Disease pattern and prognosisAplastic anemia terminating in hairy cell leukemia. A report of two casesHairy Cell Leukaemia Presenting as Aplastic AnaemiaHairy cell leukemia with bone marrow hypoplasiaGranulomatous infections complicating hairy cell leukemiaErythropoiesis in Hairy Cell Leukaemia: A True Erythroid FailureKlinik der malignen LymphomeHairy-Cell Leukemia and Aplastic AnemiaCHARLES F. WINKLER, M.D., CLIFFORD V. JENNINGS, M.D. 1 August 1979Volume 91, Issue 2Page: 228-228KeywordsAnemiaAplastic anemiaBiopsyBloodBlood cellsBone marrowCellsFibrosis ePublished: 1 December 2008 Issue Published: 1 August 1979 Copyright & Permissions© 1979 American College of PhysiciansPDF downloadLoading ...