tbuckley/cabot-search huggingface dataset:
Publish and prosper
Authors: T. Albert
Journal: BMJ (1996)

A list of publications is still a good way to impress selection shortlisters and interviewers. Tim Albert, who runs training courses in effective writing, tells how it's done 

My starting point is unusual but clear. You are the professional doctor; I am the professional writer. In order to succeed in your profession you first have to succeed (albeit briefly) in mine and become a published author in a peer reviewed journal.

You will receive copious advice from your peers, most of whom will recently, and with great difficulty, have become published authors themselves. Whether they like it or not, their experience will colour their advice, and they will almost certainly leave you with the impression that the world you seek to enter is open only to those like themselves who are highly gifted.

This article is different. It comes from the perspective of writing and editing rather than competing in science, and aims to show that getting published is not as difficult as some people might wish you to believe. It does this by challenging a number of myths about writing scientific papers, in the hope that you will be able to complete this task as soon as possible, and get back to something worth while like healing the sick.

Myth 1: A “good” paper will automatically get published. This begs the splendid question-what is a good paper?-that can occupy endless hours of useless debate and postpone publication indefinitely. It can also encourage writers to believe that the system is fair and logical.

The best way to look on the world of medical publication is as an open market, like any other. Editors may surround themselves with layers of reviewers, but essentially their job is to select papers that will enable the journal to attract enough advertising and/or readers to …
Health‐related quality of life assessment in young adults with seasonal allergic rhinitis
Authors: G. Majani, I. Biardini, A. Giardini, G.E. Senna, P. Minale, S. D'Ulisse, G. Ciprandi, W. Canonica
Journal: Allergy (2001)

Background: In health‐related quality of life (HRQL) studies on allergic rhinitis, both disease‐specific and generic questionnaires have been extensively used. Seasonal allergic rhinitis (SAR) has been studied mainly by focusing on symptomatology. The present study aimed to evaluate the SAR‐HRQL by means of two questionnaires, the Medical Outcome Study Short Form Health Survey (SF‐36) and a new instrument examining satisfaction in 32 aspects of daily life: the Satisfaction Profile (SAT‐P). Methods: Thirty‐three patients with SAR (aged 33.5±8.5 years; 12 men, 21 women) were evaluated during and 2 months after the pollen season. Data were compared with reference samples by t ‐test, and baseline and follow‐up HRQL scores were compared by a matched‐pair test. Results: Patients' HRQL scores collected during the pollen season were significantly lower than reference sample data in many SF‐36 scores and in one SAT‐P item. No differences emerged between SF‐36 and SAT‐P scores collected outside the pollen season and reference sample scores. Compared to baseline, outside the pollen season, patients reported significantly higher scores in the following SF‐36 scales: physical functioning ( P =0.002), physical role ( P =0.00001), bodily pain ( P =0.01), and vitality ( P =0.008); and significantly higher scores in only two SAT‐P items (physical well‐being [ P =0.009] and resistance to stress [ P =0.01]). Conclusions: Our data confirm the utility of using symptomatologic and health‐status questionnaires in evaluating the HRQL of SAR patients. More general quality of life questionnaires may prevent the symptomatologic and functional problems from being adequately recognized and managed. SAT‐P can be a fruitful additional tool in HRQL evaluation.
A critical assessment of in vitro tissue models for ADME and drug delivery
Authors: Kati-Sisko Vellonen, Melina Malinen, Eliisa Mannermaa, Astrid Subrizi, Elisa Toropainen, Yan-Ru Lou, Heidi Kidron, Marjo Yliperttula, Arto Urtti
Journal: Journal of Controlled Release (2014)
The “New Normal”—Reply
Authors: Sanjay V. Desai, Leonard Feldman, Joseph Cofrancesco
Journal: JAMA Internal Medicine (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Selective loss of binding sites for the glutamate receptor ligands [3H]kainate and (S)-[3H]5-fluorowillardiine in the brains of rats with acute liver failure
Authors: A Michalak, R F Butterworth
Journal: Hepatology (1997)

There is increasing evidence that alterations of glutamatergic function are implicated in the pathogenesis of central nervous system consequences of acute liver failure. The aim of the study was to assess the integrity of glutamate receptors in the brain in experimental ischemic liver failure using quantitative receptor autoradiography and the selective ligands [3H]MK801 (for N–methyl–D–aspartate [NMDA] sites), [3H]5–fluorowillardiine (for non–NMDA, α–amino–3–hydroxy–5–methyl–4–isoxazole propionic acid [AMPA] subclass sites), and [3H]kainate (for non–NMDA, kainate subclass sites). At coma stages of encephalopathy, a selective loss of up to 60% of binding sites for the kainate– and AMPA–receptor ligands was observed in cerebral cortical and hippocampal structures as well as in the hypothalamus and cerebellum. The finding of a selective loss of AMPA sites at coma stages of encephalopathy in this model of acute liver failure is consistent with previous electrophysiological reports of inhibition of AMPA–mediated neuronal depolarization resulting from exposure of hippocampal neurons to millimolar concentrations of ammonia. On the other hand, the present study showed that binding sites for the NMDA–receptor ligand [3H]MK801 at coma stages of encephalopathy in acute liver failure were within normal limits in all brain structures examined. NMDA sites are uniquely neuronal, whereas kainate and AMPA sites are localized on both neurons and astrocytes. Therefore, the selective loss of non–NMDA sites in acute liver failure may also reflect astrocytic changes in this condition. Because astrocytic glutamate receptors are implicated in K+ and neurotransmitter reuptake, alterations in their density could result in altered neuronal excitability and thus be responsible for the neurological dysfunction characteristic of hepatic encephalopathy in acute liver failure.
Ganitumab with either exemestane or fulvestrant for postmenopausal women with advanced, hormone-receptor-positive breast cancer: a randomised, controlled, double-blind, phase 2 trial
Authors: John FR Robertson, Jean-Marc Ferrero, Hugues Bourgeois, Hagen Kennecke, Richard H de Boer, William Jacot, Jesse McGreivy, Samuel Suzuki, Min Zhu, Ian McCaffery, Elwyn Loh, Jennifer L Gansert, Peter A Kaufman
Journal: The Lancet Oncology (2013)
A Textbook of Human Embryology
Authors: J. David Deck
Journal: JAMA (1964)

This relatively brief textbook of embryology represents the publication of regular lectures by Dr. Harrison at Oxford and Liverpool Universities. The method of presentation assumes substantial familiarity with anatomic nomenclature, which would perhaps limit the ways in which the book might be used. Also, in an effort to be anatomically precise, the author occasionally selects particularly cumbersome terminology, which interferes with clarity. The author's purpose in the book is to present merely a superficial account of human embryology; for further exposure the reader is referred to more comprehensive accounts.  The relative balance of subject matter may be questioned. Some topics, like reproductive anatomy, histology, and physiology, are covered in great detail, whereas other subjects of closer relevance to bodily development itself, like gut or heart development, are treated in rather shallow fashion, and no mention is made at all of glandular derivatives of the pharynx.  The figures which accompany the
Individual differences and the adaptiveness of patriarchal ideology
Authors: Kevin MacDonald
Journal: Behavioral and Brain Sciences (1999)

Campbell's target article significantly advances the field but fails to give adequate weight to individual differences. Moreover, there is no convincing rationale why males gain by making females less aggressive than they would otherwise be. It is also as likely that patriarchal ideology serves women's interests by canalizing genetic influences on individual differences within a more adaptively circumscribed range as it is to counter their interests by preventing them from challenging male hegemony.
Downstaging of Non–Small-Cell Lung Cancer Through Identification of Reversible Drug Toxicity
Authors: Eiko Theodora Browning, Jason Michael Huckleberry, Willis Bon Barrow, Nicole Lynn Restauri, Douglas Jerome Kemme, Carlyne Debra Cool, Michael John Weyant, Wilbur A. Franklin, D. Ross Camidge
Journal: Journal of Clinical Oncology (2014)
A CASE OF POTASSIUM CHLORATE POISONING.
Authors: LESTER W. DAY
Journal: JAMA (1905)

<h3>Patient.</h3> —Mr. H. W., aged 30, suffering with a slight sore throat, and not wishing to consult a physician, went to a drug store and asked the boy at the soda fountain to prescribe for him. The boy handed him a bottle containing fifty 5 grain tablets of potassium chlorate. The directions printed on the bottle were to dissolve one tablet every hour or so in the mouth until relieved. Between March 19 and April 1, the entire bottle was consumed, the last tablet being taken the afternoon of April 1. During the night of April 2, the patient began to itch and thought that the pet dog had infected him with fleas. <h3>Examination.</h3> —I was called the afternoon of April 6, and found the following condition, and in addition a temperature of 101 F.: Over his thighs, legs, ankles, trunk, forearms and wrists there appeared slightly raised reddish macules,
MHC Class I–Associated Phosphopeptides Are the Targets of Memory-like Immunity in Leukemia
Authors: Mark Cobbold, Hugo De La Peña, Andrew Norris, Joy M. Polefrone, Jie Qian, Ann Michelle English, Kara L. Cummings, Sarah Penny, James E. Turner, Jennifer Cottine, Jennifer G. Abelin, Stacy A. Malaker, Angela L. Zarling, Hsing-Wen Huang, Oliver Goodyear, Sylvie D. Freeman, Jeffrey Shabanowitz, Guy Pratt, Charles Craddock, Michael E. Williams, Donald F. Hunt, Victor H. Engelhard
Journal: Science Translational Medicine (2013)

Immunity against phosphopeptide antigens lacking in leukemia patients can be restored with stem cell transplantation.
Public Health Service Study on Reye’s Syndrome and Medications
Authors: Eugene S. Hurwitz, Michael J. Barrett, Dennis Bregman, Walter J. Gunn, Lawrence B. Schonberger, William R. Fairweather, Joseph S. Drage, John R. LaMontagne, Richard A. Kaslow, D. Bruce Burlington, Gerald V. Quinnan, Robert A. Parker, Kem Phillips, Paul Pinsky, Delbert Dayton, Walter R. Dowdle
Journal: New England Journal of Medicine (1985)

Between February and May 1984, we conducted a pilot study to examine the methods for a larger study of a previously reported relation between Reye's syndrome and medications. Thirty patients with Reye's syndrome, whose diagnosis was confirmed by an expert panel, and 145 controls were matched for age, race (black or not black), and antecedent illness (respiratory infection, chickenpox, or diarrhea) and selected from the same hospital, emergency room, or school, or identified by random digit dialing. Significantly more cases (93 per cent, 28 of 30) than members of each of the four control groups or all controls combined (46 per cent, 66 of 145) had received salicylates during matched antecedent illnesses (odds ratio of all 30 cases vs. all controls = 16.1; lower 95 per cent confidence limit = 4.6). The prevalence and mean severity score of signs, symptoms, and selected events during the antecedent illness tended to be lower among cases than controls. Thus, differences in the severity of this illness between cases and controls did not explain differences in medication exposures. This pilot study suggests an association between Reye's syndrome and the use of salicylates during an antecedent illness.
DELAYED APPEARANCE OF DEFORMITY IN VERTEBRAL BODY FRACTURES
Authors: O. O. FEASTER
Journal: JAMA (1934)

Low back pain constitutes a rather important condition in medical practice, and it is one for which the physician has often been able to do very little. Frequently this is because a compression fracture of a vertebral body has been undiagnosed. There may never have been a roentgen study of the case to account for nonrecognition, or roentgenograms may have been made properly and promptly after the injury but no abnormality was discovered.  It is my purpose in this communication to call attention to a class of spinal injuries—compression fractures of the vertebral bodies—which show no evidence of fracture deformity when roentgenograms are made immediately after the injury but on subsequent study ten days or more later do show a recognizable deformity in the lateral silhouette.  Having observed this sequence in three cases, I have made it a routine procedure in reporting a normal spine, following trauma, however slight, to
Human health risk assessment in relation to environmental pollution of two artificial freshwater lakes in The Netherlands.
Authors: H J Albering, J P Rila, E J Moonen, J A Hoogewerff, J C Kleinjans
Journal: Environmental Health Perspectives (1999)

A human health risk assessment has been performed in relation to recreational activities on two artificial freshwater lakes along the river Meuse in The Netherlands. Although the discharges of contaminants into the river Meuse have been reduced in the last decades, which is reflected in decreasing concentrations of pollutants in surface water and suspended matter, the levels in sediments are more persistent. Sediments of the two freshwater lakes appear highly polluted and may pose a health risk in relation to recreational activities. To quantify health risks for carcinogenic (e.g., polycyclic aromatic hydrocarbons) as well as noncarcinogenic compounds (e.g., heavy metals), an exposure assessment model was used. First, we used a standard model that solely uses data on sediment pollution as the input parameter, which is the standard procedure in sediment quality assessments in The Netherlands. The highest intake appeared to be associated with the consumption of contaminated fish and resulted in a health risk for Pb and Zn (hazard index exceeded 1). For the other heavy metals and for benzo(a)pyrene, the total averaged exposure levels were below levels of concern. Secondly, input data for a more location-specific calculation procedure were provided via analyses of samples from sediment, surface water, and suspended matter. When these data (concentrations in surface water) were taken into account, the risk due to consumption of contaminated fish decreased by more than two orders of magnitude and appeared to be negligible. In both exposure assessments, many assumptions were made that contribute to a major degree to the uncertainty of this risk assessment. However, this health risk evaluation is useful as a screening methodology for assessing the urgency of sediment remediation actions.
P215Tissue expression of angiotensin 2 receptor type 1 in patients with significant atherosclerosis
Authors: I Mykhailichenko, A Gnylorybov, YU Rodin, P Topolov, L Kardashevska, O Koshyk, T Shatokhina, R Jojua, V Melokhina
Journal: Cardiovascular Research (2014)

Purpose: The current study was designed to examine local renin-angiotensin system (RAS) activity on the basis of estimation of expression level of angiotensin II receptor type 1 (AT1R) in smooth muscle cells (SMCs) in intact and affected with atherosclerosis arteries in patients with significant atherosclerosis. Methods: We investigated 31 resected medium caliber arteries. 17 arteries of patients with low extremity atherosclerosis collected during vascular reconstructive operations made the first study group. The second group consisted of 14 intact mammary arteries collected during coronary bypass in subjects with multivessel coronary disease. The groups did not differ significantly by age, gender, arterial hypertension severity, concomitant disorders. AT1R localized in SMCs were detected by immunohistochemistry with specific polyclonal antibodies to AT1R. Staining intensity of angiotensin II receptors in muscular layer of arteries was assessed semiquantitatively by percentage of positive cells according to 3-level scale: ≪-≫, negative; ≪+≫, focal or week expression; ≪++≫, diffuse or strong positive reaction. Results: Similar results were achieves in both groups. In 8 arteries of the first group (47.05%) the low expression (+) of AT1R was found, in other 8 arteries the AT1R expression (47.05%) was strong. There was no AT1R expression (-) in 1 case (5.9%). Thus, significant tissue expression was observed approximately in 50% of patients with atherosclerotic arteries, moreover it did not depend on the studied vascular bed (affected or intact). Conclusions: The study results suggest that the tissue RAS activity increases inhomogeneously among patients with artery atherosclerosis. AT1R expression levels in intact arteries does not differ of those in atherosclerotic arteries (p>0.05). AT1R expression in SMCs is negative in some patients with severe atherosclerosis that puts under the doubt the key role of RAS in pathogenesis of vascular remodeling in some cases. Further researches of mechanisms that influence the level of RAS tissue components expression are needed. The studies of low susceptibility cause of mammary arteries to atherosclerosis in high RAS activity in the presence of severe lesions of arteries at other sites are required. Probably the study of efficacy of RAS inhibitors in patients with various AT1R tissue expressions will allow to develop the prognostic methods of therapy efficiency and to individualize the treatment.
46 Prevalence of hepatitis B in France, 2003–2004
Authors: C. Meffre, Y. Le Strat, E. Delarocque-Astagneau, J.M. Lemasson, D. Coste, J. Steinmetz, D. Antona, F. Dubois, J. Warszawski, J.F. Meyer, S. Leiser, J.P. Giordanella, R. Gueguen, A. Landau, J.C. Desenclos
Journal: Journal of Hepatology (2006)
Reproductive and developmental toxicity of toluene: a review.
Authors: J M Donald, K Hooper, C Hopenhayn-Rich
Journal: Environmental Health Perspectives (1991)

Toluene is a widely used industrial solvent, and humans may also have high exposures to toluene from the deliberate inhalation ("sniffing") of paint reducer, paint thinner, or paint for their narcotic effects. A number of case reports describe neonatal effects that have been attributed to toluene abuse during pregnancy. These effects may include intrauterine growth retardation, premature delivery, congenital malformations, and postnatal developmental retardation. The possibility of exposures to other fetotoxic agents, either as impurities or admixtures in toluene-containing products, or by deliberate or accidental exposures to other chemicals or drugs, cannot be excluded in these cases. The fetotoxic effects of toluene have been demonstrated in controlled studies in animals and are comparable to those observed in humans who have abused toluene-containing products before or during pregnancy. Intrauterine developmental retardation is the most clearly established effect in animals, as evidenced by decreased late fetal weight and retarded skeletal development. There is also limited evidence in rodents for skeletal and kidney abnormalities, as well as some evidence for effects on postnatal physical and possibly neurobehavioral development. Estimated daily exposures from experimental studies in animals are compared to estimated human daily intakes at the occupational permissible exposure level and at the level reported to produce euphoria in humans. Acceptable human intakes under California's Proposition 65 and under U.S. Environmental Protection Agency procedures are discussed.
Impact of Body Mass Index on Cardiac Mortality in Patients With Known or Suspected Coronary Artery Disease Undergoing Myocardial Perfusion Single-Photon Emission Computed Tomography
Authors: Xingping Kang, Leslee J. Shaw, Sean W. Hayes, Rory Hachamovitch, Aiden Abidov, Ishac Cohen, John D. Friedman, Louise E.J. Thomson, Donna Polk, Guido Germano, Daniel S. Berman
Journal: Journal of the American College of Cardiology (2006)
Improvements in Cancer Survival Rates
Authors: Matthew H. Griswold, Sidney J. Cutler, Henry Eisenberg
Journal: New England Journal of Medicine (1956)

THE Cancer Control Program in Connecticut is a Cooperative venture conducted by four organizations: the Connecticut State Medical Society; the Association of Connecticut Tumor Clinics; the Connecticut Division of the American Cancer Society; and the Connecticut State Department of Health. The efforts of these four groups are sponsored by a cancer co-ordinating committee of nine members appointed by the Connecticut State Medical Society. There are three mandatory appointments to this committee: the president of the Connecticut Cancer Society; the chairman of the Association of Connecticut Tumor Clinics; and a representative of the Connecticut State Department of Health. The other six . . .
The first case of cutaneous mucormycosis caused by Rhizopus azygosporus
Authors: A. Fujimoto, K. Nagao, K. Tanaka, J. Yamagami, S-I. Udagawa, M. Sugiura
Journal: British Journal of Dermatology (2005)

A rapidly enlarging leg ulcer appeared in a 54-year-old woman with systemic lupus erythematosus receiving aggressive immunosuppressive therapy. Skin biopsy revealed proliferation of hyphae in the midst of a neutrophilic abscess. Culture yielded Rhizopus azygosporus. As no organ involvement was detected by thorough examination, the patient was diagnosed as having primary cutaneous mucormycosis. Although intravenous amphotericin B therapy seemed to be very effective, it had to be discontinued due to nephrotoxicity. She unfortunately died of subsequent disseminated fungal infection and cerebral infarction in which the primary cause could not be determined. Minimum inhibitory concentrations of several antifungal drugs to the isolate were examined and amphotericin B proved to be the only agent that may potentially reach the effective plasma concentration. This is the first case report of cutaneous mucormycosis caused by R. azygosporus.