PENICILLIN AND SULFADIAZINE, COMPARED WITH SULFADIAZINE ALONE, IN THE TREATMENT OF PNEUMOCOCCIC PNEUMONIA
Authors: H F DOWLING, H H HUSSEY
Journal: Annals of Internal Medicine (1946)

Article1 December 1946PENICILLIN AND SULFADIAZINE, COMPARED WITH SULFADIAZINE ALONE, IN THE TREATMENT OF PNEUMOCOCCIC PNEUMONIAHARRY F. DOWLING, M.D., F.A.C.P., HUGH H. HUSSEY, M.D., F.A.C.P., HAROLD L. HIRSH, M.D., FRIEDA WILHELM, M.D.HARRY F. DOWLING, M.D., F.A.C.P.Search for more papers by this author, HUGH H. HUSSEY, M.D., F.A.C.P.Search for more papers by this author, HAROLD L. HIRSH, M.D.Search for more papers by this author, FRIEDA WILHELM, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-6-950 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptUntil the discovery of penicillin, sulfadiazine and several of its analogues were recognized universally as the drugs of choice in the treatment of pneumococcic pneumonia. When penicillin was shown to be active against pneumococci in vitro, the question of its relationship to the sulfonamides in the treatment of pneumococcic pneumonia became important. At first, since only small quantities of penicillin were available, this drug was reserved for patients who did not make the expected response to sulfonamides, but as the supply increased the problem of whether to treat all patients with penicillin from the start became paramount. In an attempt...Bibliography1. HIRSHDOWLING HLHF: Observations on the continuous intramuscular method of administering penicillin, Am. Jr. Med. Sci., 1945, ccx, 435-443. CrossrefGoogle Scholar2. DOWLING HF: Unpublished data. Google Scholar3. TILLETTMCCORMACKCAMBIER WSJEMJ: The treatment of lobar pneumonia with penicillin, Jr. Clin. Invest., 1945, xxiv, 589-594. CrossrefGoogle Scholar4. BUNNMCDERMOTTHADLEYCARTER PAWSJAC: The treatment of pneumococcic pneumonia with orally administered penicillin, Jr. Am. Med. Assoc., 1945, cxxix, 320-327. CrossrefGoogle Scholar5. MEADSHARRISFINLAND MHWM: Treatment of pneumococcal pneumonia with penicillin, New England Jr. Med., 1945, ccxxxii, 747-755. CrossrefGoogle Scholar6. KINSMANDANIELSCOHENMCCRACKEND'ALONZOMARTINKIRBY JMWBSJPCASPWM: The treatment of pneumonia with sulfonamides and penicillin, Jr. Am. Med. Assoc., 1945, cxxviii, 1219-1224. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication March 16, 1946.From the Health Department of the District of Columbia, The Gallinger Municipal Hospital, and the Departments of Medicine, the George Washington and Georgetown Universities. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Combined Effect of Penicillin and of Sulphonamides in Infections with Gram-Negative Organisms. Parts III and IVChemotherapie und antibiotische Therapie der Gonorrhoe. Allgemeine GrundlagenDie AntibioticaDie PneumonienStatistical analysis of 242 cases of meningococcus meningitisEffect of Combined Therapy on Emergence of Drug Resistant Bacteria in Urinary Tract Infections: Observations on Origin of Resistant StrainsLIGHTENING THE N.H.S. DRUG BILLSUPPLIES OF CORTISONE AND THE NEW ANTIBIOTICSSYNERGISM AND ANTAGONISM OF ANTIBACTERIAL SUBSTANCESPneumococcal Pneumonia 1 December 1946Volume 25, Issue 6Page: 950-956KeywordsDrug discoveryDrugsHospital medicinePenicillinPneumoniaSulfonamide ePublished: 1 December 2008 Issue Published: 1 December 1946 PDF downloadLoading ...