tbuckley/cabot-search huggingface dataset:
Abstract 4226: B-thujaplicin suppressed estrogen dependent breast cancer via regulating estrogen receptor signaling
Authors: Jiwon Ko, Cheng Bao, Jaehoo Lee, Hyun-Chang Park, Hong Jin Lee
Journal: Cancer Research (2014)

Abstract B-thujaplicin (Hinokitiol), a natural monoterpenoid found in the family of Chamaecyparis obtusa, has been demonstrated to exert anti-fungal, anti-bacterial, and anti-oxidant properties. However, the role of β-thujaplicin in mammary carcinogenesis has not been extensively studied. Here, we investigated the effect of β-thujaplicin on cell proliferation and underlying mechanisms in estrogen-dependent MCF-7 breast cancer cells and N-nitroso methy urea (NMU)-induced animal model. We first found that β-thujaplicin inhibited cell proliferation in a dose dependent manner, where the IC50 was 7.5 μM. The protein and mRNA expression of estrogen receptor (ER)-α was suppressed by β-thujaplicin, without affecting the level of ER-β. One of the target genes of estrogen signaling, cyclin D1 was also significantly inhibited by β-thujaplicin treatment. In animal study of NMU-induced breast cancer model, β-thujaplicin at 7.5mg/kg body weight significantly suppressed tumor growth and tumor multiplicity from 3.1 g in the control to 1.8 g in the β-thujaplicin treatment group, and from 2.9 tumor/rat to 1.7 tumor/rat, respectively. The ER-α expression and cyclin D1 in tumor tissues were also reduced by β-thujaplicin treatment. Taken together, β-thujaplicin suppressed ER-positive breast carcinogenesis through suppressing the ER-α expression and its target gene cyclin D1, and it suggests that β-thujaplicin may be a potent phytochemical in inhibiting breast cancer development. Citation Format: Jiwon Ko, Cheng Bao, Jaehoo Lee, Hyun-Chang Park, Hong Jin Lee. B-thujaplicin suppressed estrogen dependent breast cancer via regulating estrogen receptor signaling. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4226. doi:10.1158/1538-7445.AM2014-4226
Guidelines on the Net
Authors: Rebecca Voelker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Döderlein-Krönig Operative Gynäkologie.
Authors: Albert Döderlein, B Krönig
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
<scp>EURObservational</scp> Research Programme: a worldwide registry on peripartum cardiomyopathy (<scp>PPCM</scp>) in conjunction with the Heart Failure Association of the European Society of Cardiology Working Group on <scp>PPCM</scp>
Authors: Karen Sliwa, Denise Hilfiker‐Kleiner, Alexandre Mebazaa, Mark C. Petrie, Aldo P. Maggioni, Vera Regitz‐Zagrosek, Maria Schaufelberger, Luigi Tavazzi, Dirk J. van Veldhuisen, Jolien W. Roos‐Hesslink, Ajay J. Shah, Petar M. Seferovic, Uri Elkayam, Karin van Spaendonck‐Zwarts, Katrin Bachelier‐Walenta, Frederic Mouquet, Elisabeth Kraigher‐Krainer, Roger Hall, Piotr Ponikowski, John J. V. McMurray, Burkert Pieske
Journal: European Journal of Heart Failure (2014)
Abstract 19013: Effect of Vildagliptin on the Improvement of Survival in Murine Pressure-Overload Heart Failure Model
Authors: Ayako Takahashi, Masanori Asakura, Min Kyung-Duk, Shin Ito, Tetsuo Minamino, Yin Yan, Satoru Yamazaki, Shoji Sanada, Hiroshi Asanuma, Yulin Liao, Seiji Takashima, Naoki Mochizuki, Masafumi Kitakaze
Journal: Circulation (2010)

Glucagon-like peptide-1 (GLP-1) is an incretin hormone, and its analogs have been reported effective in ischemic or non-ischemic heart diseases as well as diabetes mellitus. Dipeptidyl-peptidase IV (DPP-IV) inhibitors that reduce GLP-1 degradation are considered cardioprotective for such pathophysiological states. Since heart failure (HF) is linked to impaired glucose tolerance, we aimed to clarify the effects of DPP-IV inhibitors on HF using pressure-overload hypertrophy model mice (male C57BL6 at 8 weeks of age). Cardiac hypertrophy and HF were induced by transverse aortic constriction (TAC) in a group of mice that were randomised to 2 subgroups, one of which received oral drinking water containing vildagliptin (0.2mg/ml) (TV), and the other received water only (TC). We also made 2 sham operation subgroups, one of which had the same vildagliptin dissolution (SV) and the other was a control (SC). TV had better survival curve than TC (67% vs. 38%, respectively) 14 days after TAC operation. The ratio of heart weight to body weight (mg/g) (6.12 ± 0.69 (SEM) in all TAC vs. 4.99 ± 0.17 in SC, p
THE INFLUENCE OF A NEW BENZOIC ACID DERIVATIVE ON THE METABOLISM OF PARA-AMINOSALICYLIC ACID (PAS) AND PENICILLIN
Authors: W P BOGER, J O BEATTY, F W PITTS, H F FLIPPIN
Journal: Annals of Internal Medicine (1950)

Excerpt The term chemotherapy is defined by Dorland as being  treatment of disease by administering chemicals which affect the causative organism unfavorably but do not injure the patient. Thi...
Abstract 16392: Oxido-Reductive Regulation of Human Vascular Remodeling by the Orphan Receptor Tyrosine Kinase Ros1
Authors: Ziad A Ali, Vinicio de Jesus Perez, Ke Yuan, Mark Orcholski, Stephen Pan, Wei Qi, Gaurav Chopra, Christopher Adams, Yoko Kojima, Nicholas J Leeper, Kathia Zaleta-Rivera, Kimihiko Kato, Yoshiji Yamada, Mitsutoshi Oguri, Stanley L Hazen, J Wouter Jukema, Santhi K Ganesh, Elizabeth G Nabel, Keith Channon, Martin B Leon, Alain Charest, Thomas Quertermous, Euan A Ashley
Journal: Circulation (2014)

Atherosclerosis is responsible for more deaths worldwide than any other disease process. When medical therapy fail, ischemia can be reversed by balloon angioplasty and stenting (BAS). However, BAS continues to be limited by pathological remodeling, delayed re-endothelialization and thrombosis. To better understand these processes, we characterized gene expression topology in coronary atheroma from 89 patients with either de novo atherosclerosis or in-stent stenosis (ISS). Using a systems biology approach, we identified the network hub gene glutathione peroxidase-1 (GPX1) as a putative mediator of the response to vascular injury. Mice with constitutive deletion of GPX1 were crossed onto an atherosclerotic (ApoE-/-) background and underwent BAS, demonstrating a marked elevation of ISS associated with increased medial superoxide generation and reduced endothelialization. In an independent cohort of patients that developed ISS (n=107), gene variant pair analysis identified a strong interaction of GPX1 with th...
Q fever in humans and farm animals in four European countries, 1982 to 2010
Authors: M Georgiev, A Afonso, H Neubauer, Howard Needham, R Thiéry, A Rodolakis, H J Roest, K D Stärk, J A Stegeman, P Vellema, W van der Hoek, S J More
Journal: Eurosurveillance (2013)

Q fever is a disease of humans, caused by Coxiella burnetii, and a large range of animals can be infected. This paper presents a review of the epidemiology of Q fever in humans and farm animals between 1982 and 2010, using case studies from four European countries (Bulgaria, France, Germany and the Netherlands). The Netherlands had a large outbreak between 2007 and 2010, and the other countries a history of Q fever and Q fever research. Within all four countries, the serological prevalence of C. burnetii infection and reported incidence of Q fever varies broadly in both farm animals and humans. Proximity to farm animals and contact with infected animals or their birth products have been identified as the most important risk factors for human disease. Intrinsic farm factors, such as production systems and management, influence the number of outbreaks in an area. A number of disease control options have been used in these four countries, including measures to increase diagnostic accuracy and general awareness, and actions to reduce spillover (of infection from farm animals to humans) and human exposure. This study highlights gaps in knowledge, and future research needs.
Abstract 20445: Pras40 Prevents Development of Diabetic Cardiomyopathy
Authors: Mirko Volkers, Shirin Doroudgar, Christopher Glembotski, Mark Sussman
Journal: Circulation (2014)

Introduction: Diabetes is a multi organ disease and diabetic cardiomyopathy can result in heart failure, which is a leading cause of morbidity and mortality in diabetic patients. Defects in mTOR signaling are believed to contribute to metabolic dysfunctions in diabetic liver and hearts, but evidence is missing that mTOR activation is causal to the development of diabetic cardiomyopathy. PRAS40 (Proline Rich Akt Substrate of 40kDa) is a specific component of mTORC1 that interacts with RAPTOR to inhibit mTORC1 kinase activity Methods and Results: The db/db mouse exhibits key characteristics of T2DM, namely hyperinsulinemia, insulin resistance, hyperglycemia, and develops diabetic cardiomyopathy with decreased cardiac function. Selective mTORC1 inhibition in cardiomyocytes from db/db mice in vivo was achieved using PRAS40 delivered via recombinant cardiotropic adeno-associated vector serotype 9 (AAV9) driven by a cardiomyocyte-specific myosin light chain (MLC2v) promoter construct. Myocardial dysfunction was prevented in AAV-PRAS40 treated db/db mice compared to the AAV-Control group, as seen by significantly higher cardiac ejection fraction (EF%), fractional shortening (FS%) measured by serial echocardiography, despite similar increases in body weight, serum glucose levels, and fat deposition in the liver. The effects of PRAS40 were tested in a model of T2DM induced by high fat diet (HFD). AAV-PRAS40 or AAV-Control was injected at 7 weeks of age and mice were fed HFD chow of or standard for an additional 25 weeks. Decreased cardiac function was observed in the HFD control group measured by echocardiography. This preservation of function was associated with decreased left ventricular diastolic dimension (LVID) and improved diastolic function. This phenotype was associated with improved metabolic function, blunted hypertrophic growth, and preserved insulin sensitivity. Conclusions: mTORC1 inhibition with PRAS40 prevents diabetic cardiomyopathy and improves metabolic function in diabetic mice. These findings may open novel avenues for therapeutic strategies using PRAS40 directed against diabetic-related diseases.
Essential Medical Procedures, by Ed Peter J Toghill
Authors: S. Docherty
Journal: BMJ (1997)

Ed Peter J Toghill / Arnold, £19.99, pp 147 / ISBN 0 340 63187 2

There surely cannot be a single house officer anywhere in the country whose heart has not been filled with foreboding at some stage when sent to do an unfamiliar procedure. In an ideal world we would all have an amicable senior overseeing our every trembling move during our formative months, but realistically you never feel ready to do a procedure until after you have actually done it for the first time. My first ascitic tap …
The association between psoriasis and dyslipidaemia: a systematic review
Authors: C. Ma, C.T. Harskamp, E.J. Armstrong, A.W. Armstrong
Journal: British Journal of Dermatology (2012)

Psoriasis may be associated with dyslipidaemia, a known risk factor for cardiovascular disease. This systematic review aims to synthesize evidence for the association between psoriasis and dyslipidaemia. Through a systematic search using MEDLINE, Embase and the Cochrane Central Register, from 1 January 1980 to 1 January 2012, we identified 25 observational studies that met the inclusion criteria. These 25 studies included over 2·4 million participants, among whom 265 512 were patients with psoriasis. Twenty studies (80%) reported that psoriasis was significantly associated with dyslipidaemia, with odds ratios (ORs) for dyslipidaemia ranging from 1·04 to 5·55 in 238 385 patients with psoriasis, from a population of 2 340 605 participants. Specifically, four studies defining dyslipidaemia as triglyceride levels ≥ 150 mg dL−1 reported significantly increased ORs of 1·20–4·98 for hypertriglyceridaemia in psoriasis. Three studies found that patients with psoriasis presented with significantly increased ORs (1·36–1·77) for high-density lipoprotein cholesterol levels < 40 mg dL−1, and two studies found hyperlipoproteinaemia to be significantly elevated in patients with psoriasis (ORs 1·55 and 2·09). One cohort study found a significantly higher incidence of hyperlipidaemia among patients with psoriasis (hazard ratio 1·17; 95% confidence interval 1·11–1·23). Among studies that assessed the severity of psoriasis, in 2662 patients with mild psoriasis and 810 patients with severe psoriasis, higher odds of dyslipidaemia were seen in patients with severe psoriasis. Five of the 25 studies (20%) in our review did not show any significant relationship between psoriasis and dyslipidaemia. This systematic review found that psoriasis was significantly associated with greater odds and incidence of dyslipidaemia. Greater psoriasis severity appeared to be associated with higher prevalence of dyslipidaemia.
573. Immuno Gene Therapy of Feline Fibrosarcoma Using Intratumoral Magnetofection for Gene Delivery – Preliminary Results of a Veterinary Clinical Study
Authors: Ulrike Schillinger, Niels Kjaergaard, Kathrin Wiedmann, Anne Loecher, Stefanie Schlemmer, Bianca Schwarz, Tina Kempf, Johannes Hirschberger, Roberto Koestlin, Christian Plank, Bernd Gansbacher, Thomas Brill
Journal: Molecular Therapy (2004)

Feline fibrosarcoma is one of the most common feline tumors. It arises spontaneously, is rarely metastatic and relapses within 6 months after standard therapy (surgical resection) in 75% of the cases. This makes it an ideal model for evaluating immunostimulatory therapeutic strategies. Moreover, besides aggressive surgical excision no effective and versatile treatment is available.
National Health Service Corps Faces Reauthorization During a Risky Time
Authors: C Marwick
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Limiting operations to high volume teams has wide implications
Authors: Roger Dobson
Journal: BMJ (2001)

Four out of 10 consultant firms would no longer be able to carry out at least one of 12 common elective procedures if the NHS moved to a system where only firms that carried out a high volume of specific operations were allowed to perform that particular operation.

Because it is widely believed that a higher volume of work results in better quality, organisations representing clinical specialists have begun to set minimum volume thresholds for their members, and quality assurance organisations often stipulate that providers reach certain volume requirements.

But now researchers …
Missing doctors who worked in Sri Lanka conflict zone found in government detention
Authors: Nayanah Siva
Journal: BMJ (2009)

Three doctors who went missing after working in the no fire zone in northern Sri Lanka have been detained by the Sri Lankan government and are to be tried for collaborating with the Tamil Tigers.

Yolanda Foster, a Sri Lankan researcher at Amnesty Sri International, said, “Amnesty has concerns over the lack of due process followed in the arrests of the doctors. They first went missing and only later turned up officially in custody.” 

The Sri Lankan government placed several restrictions on media coverage of the situation in northern Sri Lanka, and journalists were not allowed at the front line during the past few …
Health IT Gets a Boost
Authors: Bridget M. Kuehn
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 15609: Plasma Fibrin Clot Properties Measured Ex-vivo Are Associated With Intracoronary Thrombus Ultrastructure
Authors: Jaroslaw Zalewski, Jan Bogaert, Marcin Sadowski, Olga Woznicka, Constantinos Doulaptsis, Maria Ntoumpanaki, Michal Zabczyk, Jadwiga Nessler, Anetta Undas
Journal: Circulation (2014)

Introduction: Fibrin is a major component of intracoronary thrombus obtained during ST-elevation myocardial infarction (STEMI). Apart of the time of ischemia determinants of intracoronary thrombus composition are largely unknown. Hypothesis: We sought to investigate whether ex-vivo measured plasma fibrin clot properties are associated with intracoronary thrombus ultrastructure. Methods: In the intracoronary thrombus aspirated from 80 of the 156 consecutive STEMI patients within 12 hours since symptom onset, we assessed the content of fibrin, erythrocytes and platelets and thrombus heterogeneity by scanning electron microscopy. On admission plasma fibrin clot permeability (Ks), which indicates pore size, clot lysis time (t50%), platelet reactivity index (PRI) and aggregation induced by 5 μM of adenosine diphosphate (ADP) were correlated with intracoronary thrombus composition. Results: All patients received 300 mg of aspirin and 45 (56.3%) 600 mg of clopidogrel, 70 (41-120) min prior to aspiration. PRI inversely correlated (r=-0.24, P=0.035) with the time elapsed since clopidogrel pretreatment. The median content of fibrin, erythrocytes and platelets in intracoronary thrombus was 49.1 (25.0-72.6)%, 29.0 (4.8-57.7)% and 6.8 (1.0-15.1)%, respectively. Fibrin content was correlated with baseline Ks (r=-0.45, P&lt;0.0001), t50% (r=0.32, P&lt;0.0001), fibrinogen (r=0.32, P&lt;0.0001), the time to opening of infarct-related artery (r=0.24, P&lt;0.001), reference lumen diameter of infarct-related artery (r=0.15, P&lt;0.001), but not with PRI and ADP-induced platelet aggregation. Fibrin content was higher in patients without pre-hospital loading with clopidogrel (58 vs. 43%, P&lt;0.0001), treated with aspirin prior to STEMI (62 vs. 47%, P&lt;0.0001) or with positive family history of coronary artery disease (62 vs. 46%, P=0.0004). Multiple regression analysis adjusted for age and fibrinogen showed that Ks, time of ischemia and clopidogrel pretreatment independently predicted fibrin content in intracoronary thrombus (R2=0.44, P&lt;0.0001). Conclusion: Formation of denser fibrin clots displaying resistance to lysis, and clopidogrel pretreatment contributed to fibrin content within the intracoronary thrombus during an acute phase of STEMI.