THE EFFECT OF DORYL (CARBAMINOYLCHOLINE) IN THE TREATMENT OF PERIPHERAL VASCULAR DISEASE
Authors: Gamliel Saland, Randolph Rosenthal, Charles Klein, Herman Zurrow
Journal: Annals of Internal Medicine (1945)

Article1 July 1945THE EFFECT OF DORYL (CARBAMINOYLCHOLINE) IN THE TREATMENT OF PERIPHERAL VASCULAR DISEASEGAMLIEL SALAND, M.D., F.A.C.P., RANDOLPH ROSENTHAL, M.D., CHARLES KLEIN, M.D., HERMAN ZURROW, M.D.GAMLIEL SALAND, M.D., F.A.C.P.Search for more papers by this author, RANDOLPH ROSENTHAL, M.D.Search for more papers by this author, CHARLES KLEIN, M.D.Search for more papers by this author, HERMAN ZURROW, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-1-48 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCarbaminoylcholine, known popularly as Doryl, is one of the most powerful parasympathomimetic drugs known. As a choline derivative, its properties causing general vasodilatation suggested its use in peripheral vascular disease. The literature is sparse with reference to its use in this connection. Starr,1 in 1937, reported striking relief of rest pain except in the presence of gangrene or undrained purulent infection.Chemistry and Pharmacology.1, 2Carbaminoylcholine chloride (NH2COOCH2CH2N(CH3)3Cl) was first synthesized in 1932 by Kreitmair. Its actions parallel the effects produced by stimulation of the parasympathetic nerves such as general vasodilatation, drop in blood pressure, increased salivation, gastrointestinal peristalsis, uterine...Bibliography1. STARR I: Carbaminoylcholine (Doryl or Lentin). Its action on normal persons in peripheral vascular disease, and in certain other clinical conditions, Am. Jr. Med. Sci., 1937, cxciii, 393. CrossrefGoogle Scholar2. GOODMANGILMAN LA: The pharmacological basis of therapeutics, 1943, Macmillan Company, New York, p. 367. Google Scholar3. ZURROWSALANDKLEINGOLDMAN HGCS: The effect of testosterone propionate in the treatment of arteriosclerosis obliterans, Jr. Lab. and Clin. Med., 1942, xxviii, 269. Google Scholar4. KLEINSALANDZURROW CGH: Pancreatic tissue extract (insulin-free) in the treatment of peripheral vascular disease, Ann. Int. Med., 1943, xviii, 214. Google Scholar5. SALANDKLEINZURROWGOOTNICKKATZ GCHAA: Criteria for the classification and diagnosis of peripheral vascular diseases, Arch. Int. Med., 1940, lxv, 1035. CrossrefGoogle Scholar6. SALANDKLEINZURROW GCH: The thermal reflex vasodilatation test in peripheral vascular disease, Am. Heart Jr., 1939, xvii, 581. CrossrefGoogle Scholar7. GOOTNICKSALANDKLEINZURROW AGCH: Studies on vasodilatation tests in peripheral vascular disease, Jr. Lab. and Clin. Med., 1942, xxvii, 878. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication October 5, 1944.From the Peripheral Vascular Disease Department, The Bronx Hospital, Bronx, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1945Volume 23, Issue 1Page: 48-52KeywordsBlood pressureChloridesDrugsNervesPeripheral vascular diseaseSalivationVasodilation ePublished: 1 December 2008 Issue Published: 1 July 1945 PDF downloadLoading ...