tbuckley/cabot-search huggingface dataset:
Abstract 18479: Cohort Under-Ascertainment of Prevalent Atrial Fibrillation Using the Baseline 12-Lead ECG: Implications for Atrial Fibrillation “Prediction”
Authors: Jonathan W Dukes, Mary A Whooley, Gregory M Marcus
Journal: Circulation (2014)

Introduction: Many major cohort studies base their ascertainment of prevalent AF on the enrollment electrocardiogram (ECG). The sensitivity of this approach remains unknown. It is critical to exclude all incident AF analyses because AF itself can have important anatomic and physiologic effects. Hypothesis: The sensitivity of AF ascertainment by baseline ECG alone is poor. Methods: The Heart and Soul Study (H&amp;S) enrolled 1024 ambulatory men and women with established coronary artery disease between September 2000 and December 2002 from four sites within the San Francisco Bay Area. We identified all H&amp;S participants receiving care at the Veterans Administration (VA) (n=425), a single payer system with comprehensive electronic medical records. A baseline study ECG was performed on all subjects. A thorough review of electronic medical records was performed by an electronic key word query. All available ECGs were directly reviewed and overread by a board certified electrophysiologist. Paper charts for all non-VA hospital admissions after study enrollment were also directly reviewed. Results: The 425 participants were followed for a median 10.5 years (interquartile rage [IQR] 5.7 [[Unable to Display Character: &amp;#8211;]] 11.8). Prevalent AF was identified in 23 participants (5.4%) by baseline study ECG, and 77 participants (18%) by thorough chart review (p&lt;0.001). Compared to chart review, ascertainment of prevalent AF by baseline ECG had a sensitivity of 30% and a specificity of 100% (ROC area 0.649). If only participants with prevalent AF on baseline ECG were excluded (hence misclassifying 54, or 13% of all participants, as having no history of AF), 139 (35%) of participants would have been classified as developing incident AF. In contrast, after excluding all participants with prevalent AF determined by chart review, 84 (24%) are categorized as developing incident AF. Conclusion: Despite common practices in major cohort studies, the sensitivity of the baseline ECG for prevalent AF is poor. This may lead to common misclassification of prevalent AF participants as developing incident AF, resulting in the false identification of “predictors” of AF that are in fact due to extant AF.
Abstract 13481: Early Effect of Bezafibrate on Fibrinogen Levels, Inflammatory Response and Clinical Impact, in Patients With St Elevation Acute Myocardial Infarction
Authors: Alejandra Madrid Miller, Luis A Moreno Ruiz, Francisco Solis Nuñez, Luis Chávez Sánchez, Gabriela Borrayo Sánchez, Eduardo Almeida Gutiérrez, Karina Chávez Rueda, Francisco Blanco Favela
Journal: Circulation (2014)

Introduction:  Plasma fibrinogen levels have been identified as an important risk factor for cardiovascular diseases and could have a prognostic value. Bezafibrate decreases fibrinogen levels and also the incidence of major cardiovascular events in primary prevention, but its effects in acute coronary syndrome is unknown   Hypothesis:  Bezafibrate effect over statin therapy reduces fibrinogen concentrations, inflammatory response and clinical events, in patients with ST segment elevation ACS and hyperfibrinogenemia.   Methods:  In a randomized clinical trial, controlled with conventional therapy. We included patients with ST elevation acute myocardial infarction (STEAMI) and with fibrinogen concentration >500 mg/dl at 72 h of evolution, were randomly assigned to bezafibrate 400 mg/day (group I n=50) or just conventional therapy (group II n=50). Serum fibrinogen, c reactive protein and cytokines were measured. Clinical end points were recurrence of angina or infarction, left ventricular failure, cardiovascular mortality and combined end points during hospitalization.   Results:  Levels of Fibrinogen (462 Vs 658 mg/dl), C reactive protein (2.78 Vs 6.0mg/dl), IL-6 (median 2.83 Vs 9.57pg/ml) were significantly lower at hospital discharge in Group I (figure 1). Clinical end points were more frequent in Group II than in Group I (angina 18% Vs 2% p   Conclusions:  The additive effect of bezafibrate over statin, significantly reduced fibrinogen levels and the inflammatory response in patients with STEAMI and hyperfibrinogenemia. In the short term, this reduction was associated with a lower incidence of major cardiovascular events
Abstract 3902: Liver cancer stem cells initiate extracellular matrix remodeling
Authors: Zhiqian Zhang, Wei Zhao, Xueying Yang, Haibo Han
Journal: Cancer Research (2014)

Abstract Extracellular matrix is one of the major components of cancer cell's niche. It is well appreciated that extracelluar matrix undergoes remodeling during the process of tumor progression,but the causal factors that initiate extracellular matrix remodeling are poorly understood. Hepatocellular carcinoma, like many other solid tumors, is thought to be hierarchically organized heterogeneous populations of cells with the cancer stem cell compartment sitting on top. We have identified a population of hepatocellular carcinoma cells, which were defined as α2δ1+ cells, exhibiting stem cell-like properties, such as increased invasiveness, expression of stem cell associated genes (OCT4, SOX2, NANOG, and BMI1), increased self-renewal, and the ability of giving rise to both α2δ1+ and α2δ1- cells with a novel monoclonal antibody, 1B50-1, using a whole-cell subtractive immunization approach that recognizes the isoform 5 of the cell surface voltage-gated calcium channel α2δ1 subunit. In order to understand the role of extracellular matrix in the regulation of α2δ1+ hepatocellular carcinoma stem cell properties, we first compared the expression of extracellular matrix components between α2δ1+ and α2δ1- cells. Comparing with α2δ1- cells, the expression of collagen isoforms such as COL6A3, COL1A2, and COL21A1 was up-regulated, while COL1A1, COL2A1, COL6A2 were down-regulated in α2δ1+ hepatocellular carcinoma cells. Interestingly, the collagen cross-linking enzyme-lysyl oxidase (LOX) was also upregulated in α2δ1+ liver cancer stem cells. Furthermore, as a direct target of microRNA-200b which was down-regulated in α2δ1+ liver cancer stem cells, LOX is sufficient to enable α2δ1− liver cancer cells to acquire cancer stem cell-like properties such as self-renewal and tumorigenicity. Knock-down of LOX in α2δ1+ liver cancer stem cells has resulted in decrease of self-renewal and tumorigenic properties. This data suggest that hepatocellular carcinoma stem cells may initiate their niche remodeling to maintain their cancer stem cell properties. Citation Format: Zhiqian Zhang, Wei Zhao, Xueying Yang, Haibo Han. Liver cancer stem cells initiate extracellular matrix remodeling. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3902. doi:10.1158/1538-7445.AM2014-3902
Abstract 12852: The Incremental Value of Three-Dimensional Transesophageal Echocardiography for the Diagnostic Assessment of Infective Endocarditis
Authors: Fabio Chirillo, Marta Possamai, Matteo Rugolotto, Paola Martire, Giuseppe Minniti, Sara Giacomelli, Piergiorgio Scotton, Elvio Polesel, Zoran Olivari
Journal: Circulation (2014)

Two-dimensional transesophageal echocardiography (2D TEE) may fail to detect signs of infective endocarditis (IE) or to delineate complex anatomic lesions due to suboptimal visualization of the infected area. Three-dimensional (3D) TEE may have additional value; however, data are scarce. In 124 consecutive patients (85 M; Mean age 63 ± 14 years) with definite IE involving the aortic (36), mitral (35), tricuspid (5), ≤ 1 valve (6), and prosthetic valves (30),or pace-maker/ICD leads (12) the comparative analysis between 2D and 3D imaging focused on: 1) Presence and maximal dimension of vegetations; 2) Prediction of embolic events; 3) Location and dimension of valve perforation; 3) Prediction of successful mitral valve repair; 4) Identification and morphologic assessment of perivalvular complications.3D TEE detected more vegetations per patient (1.9 ± 2.1 vs 1.7± 1.6; p= 0.06), but this difference was significant only for vegetations on prosthetic valves and PM/ICD leads (2.2 ± 1.7 vs 1.1 ± 1.5; p=0.03). TomTec Software was used to crop the 3D volume to obtain the largest value for vegetations and perforation area. The 3D TEE maximal vegetation dimension was larger with a mean difference of 2.9 mm (95% CI, 1.9-4.52 mm) vs 2DTEE. The best cut-off value for prediction of embolic events was ≥18 mm with 3D TEE and ≥14 mm with 2D TEE. The positive predictive value for 3D TEE was not statistically higher (58% vs 52%). Valve perforation was identified in 10/19 patients with 2D TEE and in 18/19 patients with 3D TEE (p&lt; 0.007) with subsequent surgical confirmation. Successful mitral valve repair was associated with a distance of the perforation &gt; 3 mm from the leaflet tip and from commisures. This information was provided only by 3D TEE. Finally, 2D TEE missed 2/20 peri-annular extensions. After addition of 3D TEE all peri-annular extensions (20/20) were detected, without adding false positives.In 5 patients contrast 3D TEE provided visualization of the full extent of the defect and its precise anatomical location, prior to successful surgical resection. In conclusion 3D TEE is a feasible technique for the analysis of vegetation size and complex cardiac lesions caused by IE that may overcome the limitations of 2D TEE, providing incremental information useful for surgery
Abstract 658: A bispecific HER2 targeting FynomAb with superior anti-tumor activity and novel mode of action
Authors: Babette Schade, Simon Brack, Isabella Attinger-Toller, Kristina Klupsch, Richard Woods, Helen Hachemi, Ulrike von der Bey, Susann Koönig-Friedrich, Julian Bertschinger, Dragan Grabulovski
Journal: Cancer Research (2014)

Abstract Upregulation of HER2 is a hallmark of 20% to 30% of invasive breast cancers, rendering this receptor an attractive target for cancer therapy. Although HER2 targeting agents have provided substantial clinical benefit as cancer therapeutics, there is a need for the development of new agents aiming at circumventing anti-HER2 resistance. Fynomers are small 7 kDa globular proteins derived from the SH3 domain of the human Fyn kinase (Fyn SH3) that can be engineered to bind with antibody-like affinity and specificity to virtually any target of choice. Fynomers can be fused to N-terminal and/or C-terminal ends of antibodies to generate multispecific therapeutics (FynomAbs) with tailored architectures. FynomAbs can be produced using standard antibody technology (GMP production yield of 3.3 g/L at 1000 L scale achieved), and show IgG-like biophysical properties and pharmacokinetic profiles. Based on the approved antibody pertuzumab we have created a panel of bispecific FynomAbs which target two epitopes on HER2. The activity of the HER2 targeting FynomAbs was found to depend on the FynomAb architecture, i.e. the spatial arrangement of the binding sites of antibody and the Fynomer. The most potent of these FynomAbs, termed COVA208, demonstrated superior tumor cell growth inhibition in vitro compared to pertuzumab and trastuzumab. COVA208 was characterized in detail and showed an increased ability to induce rapid HER2-internalization and apoptosis in vitro. Moreover, it elicited a stronger inhibition of downstream HER2 signaling which was accompanied by a reduction of HER2, HER3 and EGFR levels in vitro and in vivo. The therapeutic potential of COVA208 has been demonstrated in vivo in four different HER2 mouse models, where COVA208 exhibited excellent anti-tumor activity. Importantly, COVA208 demonstrated superior activity in vivo compared to trastuzumab and pertuzumab. The bispecific FynomAb COVA208 has the potential to enhance the clinical efficacy and expand the scope of HER2-directed therapies, and delineates a paradigm for designing a new class of antibody-based therapeutics for other receptor targets. Citation Format: Babette Schade, Simon Brack, Isabella Attinger-Toller, Kristina Klupsch, Richard Woods, Helen Hachemi, Ulrike von der Bey, Susann Koönig-Friedrich, Julian Bertschinger, Dragan Grabulovski. A bispecific HER2 targeting FynomAb with superior anti-tumor activity and novel mode of action. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 658. doi:10.1158/1538-7445.AM2014-658
INITIAL MANAGEMENT OF TUBERCULOSIS WITH SPECIAL REFERENCE TO THE PSYCHOLOGY OF THE PATIENT
Authors: Lewis J. Moorman
Journal: Annals of Internal Medicine (1939)

Article1 November 1939INITIAL MANAGEMENT OF TUBERCULOSIS WITH SPECIAL REFERENCE TO THE PSYCHOLOGY OF THE PATIENTLEWIS J. MOORMAN, M.D., F.A.C.P.LEWIS J. MOORMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-13-5-849 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe initial management of pulmonary tuberculosis would be relatively simple were it not for the patient. Modern methods of diagnosis make it possible to observe, record, and evaluate the symptoms and signs of the disease. The nature and extent of anatomic changes may be accurately estimated and, by means of the roentgen-ray, visualized. With all the data available through the application of the usual diagnostic methods, the well informed physician should experience little difficulty in planning the most logical form of management. But, the effective execution of any program based upon symptoms and the purely physical and pathological conditions, must... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Oklahoma City, Oklahoma*Received for publication April 28, 1938. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1939Volume 13, Issue 5Page: 849-855KeywordsPsychologySigns and symptoms ePublished: 1 December 2008 Issue Published: 1 November 1939 PDF downloadLoading ...
Carbon Monoxide Poisoning
Authors: Malcolm Lader, Robin Morris
Journal: Journal of the Royal Society of Medicine (2001)

As Dr Blumenthal indicates (June 2001 JRSM, pp. 270-272), much is known about the acute effects of carbon monoxide poisoning and quite a lot about the long-term sequels of such poisoning. However, much less has been published about the effects of chronic low-grade exposure to carbon monoxide poisoning. This is often extremely insidious and is usually not detected during the exposure but only later after realization that a gas-fired appliance is defective.

During the exposure the common symptoms are headache, nausea and weakness; vomiting and dizziness may also be complained of. Lethargy can be a particularly severe symptom and may result in a misdiagnosis of chronic fatigue syndrome.

Our experience encompasses over 30 such cases. The psychiatric effects of chronic exposure include irritability, depression and lability of mood. Neurological signs are usually absent. The neuropsychological pattern on detailed testing is impairment of attention, short-term memory and executive functioning.

We wish to draw doctors' attention to this syndrome as it is easily overlooked.
Abstract 14099: Prognostic Values of C-Reactive Protein Levels on Clinical Outcome After Endovascular Therapy in Hemodialysis Patients with Peripheral Artery Disease
Authors: Hideki Ishii, Hiroshi Takahashi, Toru Aoyama, Takanobu Toriyama, Miho Tanaka, Yoshihiro Kawamura, Tetsuya Amano, Tatsuaki Matsubara, Toyoaki Murohara
Journal: Circulation (2010)

Background: Endovascular therapy (EVT) has been widely performed for peripheral artery disease. However, the high restenosis rate after EVT remains a major problem in patients on hemodialysis. Rece...
Early diet in preterm babies and later intelligence quotient
Authors: D. Behrman, M. Broadfoot, P. Buchanan, C. Lamont, M. Sachs, A. Lucas, T. Cole, R. Morley
Journal: BMJ (1999)

Is there a rationale for rationing chronic dialysis? Two points need clarificationEditor-I agree with Chandna et al that late referral is an important factor in the survival of patients receiving dialysis. 1I am unaware, however, of the source of their information that an NHS consensus statement recommends that nephrology referrals be made at a serum creatinine concentration > 135 mol/l in women and > 180 mol/l in men.The workload generated by this practice would be so enormous that British renal units under present conditions would be unable to cope.I am also concerned that of the authors' 292 patients receiving dialysis, 26 (admittedly high risk) patients spent 44% of their lives in hospital.The costs of inpatient treatment for these high risk patients would be substantially higher than the average cost of £250 a day that the authors quote.
Abstract 71: Is the new Basic Life Support protocol (2005) easier to learn?
Authors: Jozsef Betlehem, Gabor Nagy, Jozsef Marton, Zsigmond Gondocs
Journal: Circulation (2007)

Objectives: The effective learning of basic life support (BLS) skills in the process of training is always an important expectation during the course. Each assessment of BLS training is a complex, continuous action where the evaluation should not be subjective by using the examiner’s experiences only. In order to reach the reliable standard of pedagogical assessment, our department developed a score to ensure more objectivity on BLS examination. Methods: The developed scoring tool which is consistent with the steps of 2000 and 2005 ERC BLS protocols was introduced at the faculty. After a trial period we assessed in a cross sectional study design 156 students in 2005/2006 first semester based on 2000 ERC BLS, and 207 students in 2006/2007 first semester based on 2005 ERC BLS protocol. The volunteers are between the age 18 and 25 years, and all students studied the same BLS protocol in 28 hours/semester. The data were analyzed by Chi Square test and cross tabulation with SPSS 11.00. Results: The positive results in all steps of 2005 BLS protocol were correlating with successful of BLS exams significantly. Comparing the five steps of 2005 BLS protocol to 2000 BLS protocol, the checking for responsiveness (p=0,001), shouting for help (p=0,013), checking for breathing (p=0,000; Phi 0,068 vs 0,459), chest compression (p=0,000; Phi: 0,443 vs 0,472), breathing (p=0,000 Phi: 0,360 vs 0,764), seemed to be influencing the successful exams in the 2005 ERC BLS protocol significantly, which made it easier to learn the new protocol, too. There was not significant correlation between the genders in case of 2000 or 2005 BLS protocol. Conclusions: Our earlier developed score is useful in evaluating the 2005 BLS protocol and the new protocol can be learned more successfully.
Abstract 3285: Attenuation of Doxorubicin-Induced Cardiomyopathy in Endothelin Converting Enzyme-1 Heterozygous Knockout Mice Through Preventing the Impairment of Cardiac Mitochondrial Biogenesis
Authors: Kazuya Miyagawa, Noriaki Emoto, Nur Arfian, Dyah Samti Mayasari, VIta Yanti Anggraeni, Hirowati Ali, Bambang Widyantro, Kazuhiko Nakayama, Ken-ichi Hirata
Journal: Circulation (2009)
The Effects of Aerobic Exercise on Glucose and Counterregulatory Hormone Concentrations in Children With Type 1 Diabetes
Authors: Michael J Tansey, Eva Tsalikian, Roy W Beck, Nelly Mauras, Bruce A Buckingham, Stuart A Weinzimer, Kathleen F Janz, Craig Kollman, Dongyuan Xing, Katrina J Ruedy, Michael W Steffes, Timothy M Borland, Ravinder J Singh, William V Tamborlane
Journal: Diabetes Care (2006)

OBJECTIVE—To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes.
P0412 : Netrin-1 protects against hepatocytic cell death upon UPR through sustained translation in an UNC5A/C-dependent fashion
Authors: T. Lahlali, M.-L. Plissonnier, M. Michelet, C. Romero-Lopez, B. Ducarouge, F. Zoulim, P. Mehlen, R. Parent
Journal: Journal of Hepatology (2015)
A case of follicular mucinosis treated successfully with minocycline
Authors: S. Yotsumoto, H. Uchimiya, T. Kanzaki
Journal: British Journal of Dermatology (2000)

Journal Article A case of follicular mucinosis treated successfully with minocycline Get access S. Yotsumoto, S. Yotsumoto Department of Dermatology, Faculty of Medicine, Kagoshima University, 8‐35‐1 Sakuragaoka, Kagoshima 890‐0025, Japan E‐mail: syotsumo@med5.kufm.kagoshima‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar H. Uchimiya, H. Uchimiya Department of Dermatology, Faculty of Medicine, Kagoshima University, 8‐35‐1 Sakuragaoka, Kagoshima 890‐0025, Japan E‐mail: syotsumo@med5.kufm.kagoshima‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Kanzaki T. Kanzaki Department of Dermatology, Faculty of Medicine, Kagoshima University, 8‐35‐1 Sakuragaoka, Kagoshima 890‐0025, Japan E‐mail: syotsumo@med5.kufm.kagoshima‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 142, Issue 4, 1 April 2000, Pages 841–842, https://doi.org/10.1046/j.1365-2133.2000.03454.x Published: 01 April 2000
The perils of free speech
Authors: R. Smith
Journal: BMJ (2003)

adrenaline auto-injectors, but only a few patients know how and when to use them. Health service research has to improveHealth service research is still not making its full contribution to health service improvement.In the Education and Debate section, Dash and collaborators (p 1339) analyse the status of health research in the United Kingdom and in parts of the United States and Canada.Researchers and managers are unhappy with the limited applicability of some research, and policy makers feel research findings are not available when decisions are being taken.The experiences from North America suggest that independent organisations can help bring together users, funders, and researchers.
The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data
Authors: Jane Achan, Ishag Adam, Emmanuel Arinaitwe, Elizabeth A. Ashley, Ghulam Rahim Awab, Mamadou S. Ba, Karen I. Barnes, Quique Bassat, Steffen Borrmann, Teun Bousema, Prabin Dahal, Umberto D'Alessandro, Timothy M.E. Davis, Arjen M. Dondorp, Grant Dorsey, Chris J. Drakeley, Caterina I. Fanello, Babacar Faye, Jennifer A. Flegg, Oumar Gaye, Peter W. Gething, Raquel González, Philippe J. Guerin, Simon I. Hay, Tran T. Hien, Bart Janssens, Moses R. Kamya, Corine Karema, Harin A. Karunajeewa, Moussa Koné, Bertrand Lell, Kevin Marsh, Mayfong Mayxay, Clara Menéndez, Petra F. Mens, Martin Meremikwu, Clarissa Moreira, Ivo Mueller, Carolyn Nabasumba, Michael Nambozi, Jean Louis Ndiaye, Paul N. Newton, Thuy Nhien Nguyen, Francois Nosten, Christian Nsanzabana, Sabah A. Omar, Jean Bosco Ouédraogo, Louis K. Penali, Mbaye Pene, Aung Pyae Phyo, Patrice Piola, Ric N. Price, P. Sasithon, Philip J. Rosenthal, Albert Same-Ekobo, Patrick Sawa, Henk D.F.H. Schallig, Seif A. Shekalaghe, Carol Hopkins Sibley, Jeff Smith, Frank Smithuis, Anyirékun Fabrice Somé, Kasia Stepniewska, Ambrose O. Talisuna, Joel Tarning, Emiliana Tjitra, Roger C.K. Tine, Halidou Tinto, Neena Valecha, Michel Van Herp, Michele Van Vugt, Nicholas J. White, Charles J. Woodrow, William Yavo, Adoke Yeka, Issaka Zongo
Journal: PLoS Medicine (2013)

Ric Price and colleagues pool individual patient data from efficacy trials of dihydroartemisinin-piperaquine shared with WWARN (Worldwide Antimalarial Resistance Network) to examine the potential for underdosing in young children. Please see later in the article for the Editors' Summary