tbuckley/cabot-search huggingface dataset:
153 Acute hepato-cellular failure with encephalopathy in French patients with autochthonous acute sporadic hepatitis E
Authors: J.M. Péron, H. Poirson, C. Bureau, J.M. Mansuy, J. Selves, L. Alric, S. Métivier, E. Dupuis, J. Izopet, J.P. Vinel
Journal: Journal of Hepatology (2006)
Abstract 1683: ALK F1174L kinase activity as driver of cell proliferation in neuroblastoma cell line models and neuroblastoma tumors
Authors: Riet Hilhorst, Liesbeth Hovestad, Rik de Wijn, Dirk Pijnenburg, Rob Ruijtenbeek, Alexander Schramm, Angelika Eggert, Johannes H. Schulte
Journal: Cancer Research (2012)

Abstract Background. Whereas ALK translocations play a role in tumor growth in selected NSCLC cases, mutated forms of ALK have been shown to drive development of neuroblastoma, the most common malignant extracranial tumor of childhood. The mutation F1147L in the oncogene ALK increases the kinase activity, causing deregulated proliferation of sympatho-adrenal progenitor cells. We explored the use of kinase activity measurements to identify ALK activity in cell lysates and patient derived tissue lysates with the aim of identifying biomarkers to trace the activity of ALK in tumors and the effect of ALK inhibitors on these marker signals. Methods. Protein kinase activities were measured on PamChip® peptide microarrays comprising 144 Tyr containing peptide sequences from known human phosphorylation sites. The activity profiling experiments involved recombinant ALK kinase, lysates of cell lines overexpressing ALK and neuroblastoma tumors with elevated ALK F1174L presence. Per microarray analysis 5 ug of total protein was used in the presence of 100 uM ATP. Experiments were performed in the presence and absence of ALK kinase inhibitors crizotinib and NVP-TAE684. Real time kinetics of 144 peptide phosphorylations were measured with a fluorescently labeled antibody. Results. Phosphorylation profiles for neuroblastoma tumors, ALK overexpressing cell lines and recALK were generated. For recALK 48 novel peptide substrates were identified that showed signals depending on both ATP and kinase concentration and inhibition by the ALK inhibitors. In ALK overexpressing cell lines, but not in control cell lysates, signals on many ALK substrate peptides were significantly elevated, and returned to baseline level in the presence of ALK inhibitors. Whereas neuroblastomas with low ALK expression gave similar kinase activity profiles, the tumors harboring the ALK F1174L mutation were different, suggesting a more complex regulation of phosphorylation activity in these tumors. All tumors showed on-chip responses with ALK inhibitor drugs, but to different extent, which could be a basis for response prediction biomarker discovery. Conclusion. ALK activity of recombinant kinases, cell lysates and tumor lysates can be detected on PamChip® peptide microarrays. Based on results with model systems, this method shows promise to identify tumors that express elevated ALK activity and to study response of this class to ALK inhibitors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1683. doi:1538-7445.AM2012-1683
Suppression of Central Sleep Apnea by Continuous Positive Airway Pressure and Transplant-Free Survival in Heart Failure
Authors: Michael Arzt, John S. Floras, Alexander G. Logan, R. John Kimoff, Frederic Series, Debra Morrison, Kathleen Ferguson, Israel Belenkie, Michael Pfeifer, John Fleetham, Patrick Hanly, Mark Smilovitch, Clodagh Ryan, George Tomlinson, T. Douglas Bradley
Journal: Circulation (2007)

In the main analysis of the Canadian Continuous Positive Airway Pressure (CPAP) for Patients with Central Sleep Apnea (CSA) and Heart Failure Trial (CANPAP), CPAP had no effect on heart transplant-free survival; however, CPAP only reduced the mean apnea-hypopnea index to 19 events per hour of sleep, which remained above the trial inclusion threshold of 15. This stratified analysis of CANPAP tested the hypothesis that suppression of CSA below this threshold by CPAP would improve left ventricular ejection fraction and heart transplant-free survival.Of the 258 heart failure patients with CSA in CANPAP, 110 of the 130 randomized to the control group and 100 of the 128 randomized to CPAP had sleep studies 3 months later. CPAP patients were divided post hoc into those whose apnea-hypopnea index was or was not reduced below 15 at this time (CPAP-CSA suppressed, n=57, and CPAP-CSA unsuppressed, n=43, respectively). Their changes in left ventricular ejection fraction and heart transplant-free survival were compared with those in the control group. Despite similar CPAP pressure and hours of use in the 2 groups, CPAP-CSA-suppressed subjects experienced a greater increase in left ventricular ejection fraction at 3 months (P=0.001) and significantly better transplant-free survival (hazard ratio [95% confidence interval] 0.371 [0.142 to 0.967], P=0.043) than control subjects, whereas the CPAP-CSA-unsuppressed group did not (for left ventricular ejection fraction, P=0.984, and for transplant-free survival, hazard ratio 1.463 [95% confidence interval 0.751 to 2.850], P=0.260).These results suggest that in heart failure patients, CPAP might improve both left ventricular ejection fraction and heart transplant-free survival if CSA is suppressed soon after its initiation.
Successful treatment of disseminated cutaneous cytomegalic inclusion disease associated with Hodgkin's disease
Authors: Hisashi Sugiura, Takayuki Sawai, Harumitsu Miyauchi, Masami Uehara, Shohei Watanabe, Hidetoshi Okabe, Yosbiyuki Ishizuka
Journal: Journal of the American Academy of Dermatology (1991)
Obliterative Pulmonary Hypertension and Thrombo-embolism
Authors: J. F. Goodwin, C. V. Harrison, D. E. L. Wilcken
Journal: BMJ (1963)

<h3>Abstract</h3> Structural variants (SV) have been linked to important bovine disease phenotypes, but due to the difficulty of their accurate detection with standard sequencing approaches, their role in shaping important traits across cattle breeds is largely unexplored. Optical mapping is an alternative approach for mapping SVs that has been shown to have higher sensitivity than DNA sequencing approaches. The aim of this project was to use optical mapping to develop a high-quality database of structural variation across cattle breeds from different geographical regions, to enable further study of SVs in cattle. To do this we generated 100X Bionano optical mapping data for 18 cattle of nine different ancestries, three continents and both cattle sub-species. In total we identified 13,457 SVs, of which 1,200 putatively overlap coding regions. This resource provides a high-quality set of optical mapping-based SV calls that can be used across studies, from validating DNA sequencing-based SV calls to prioritising candidate functional variants in genetic association studies and expanding our understanding of the role of SVs in cattle evolution.
Stability of blood pressure rank and urinary kallikrein concentration in childhood: an eight-year follow-up.
Authors: S H Zinner, H S Margolius, B Rosner, E H Kass
Journal: Circulation (1978)

Previous studies in a population of 721 children aged 2--14 years demonstrated the familial aggregation of blood pressure in children, and a significant regression coefficient (b = 0.25) of follow-up on initial blood pressures over a four-year period. Urinary kallikrein concentration (UKal) also aggregated in families, was lower in black than in white children and was inversely related to blood pressure. Further studies in the same cohort have been conducted. These variables were again measured in 484 children in 129 families seven to eight years after the initial blood pressure and three to four years after the original UKal measurements were made. Familial aggregation again was found for blood pressure and urinary kallikrein. Blood pressure tracking was demonstrated by the finding that blood pressure scores at the third survey were related significantly to those at both previous surveys. Kallikrein concentrations in casual urines at Survey 3 were related to those obtained at Survey 2 (r = 0.499), and were again significantly lower in black than in white children (log = 3.84 +/- 0.8 vs 4.37 +/- 0.7; P less than 0.001). These were significant inverse relations between UKal/creatinine concentration and blood pressure in both white and black children. Thus, familial aggregation of blood pressure, blood pressure rank and concentration of kallikrein in casual urine specimes are relatively stable in children over an eight-year period of observation. This study demonstrates in a free living population of normal children, a stable relation between blood pressure and an enzyme which is involved in the production of potent vasodilator peptides and is related to hypertension in adults.
Nail changes due to docetaxel
Authors: K. Pavithran, D.C. Doval
Journal: British Journal of Dermatology (2002)

British Journal of DermatologyVolume 146, Issue 4 p. 709-710 Nail changes due to docetaxel First published: 28 April 2002 https://doi.org/10.1046/j.1365-2133.2002.46824.xCitations: 26Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume146, Issue4April 2002Pages 709-710 RelatedInformation
Massive Surgical Emphysema, Pneumothorax, Pneumoperitoneum
Authors: R. Jones
Journal: BMJ (1945)

ratio of the difference to its standard error exceeds 2, and the decrease in the second period may therefore be regarded as a real one.Discussion The objective of the analysis was to ascertain whether or not the two series of patients were similar in all respects except as regards treatment and to make allowances for differ- ences which might be found.The results show similarity in regard to parity and type of operation, but dissimilarity in regard to age and indication.While the conclusion must be that the " paralytic ileus " rate was lowered after morphine therapy started, the statistical analysis can only be claimed to show that the decrease was greater than could easily be ascribed to chance and that it was not due to inherent differences in the two series as regards age, parity, and type. of operation or indication. ConclusionThe essential difference between the two series of cases from the clinical point of view is the introduction of a morphine routine in the second group, and we feel that the results (5% paralytic ileus as against 0.88%') are attributable to this factor, as the two series are as near parallel as can be expected in 500 consecutive Caesarean sections.
Effective detection of rare variants in pooled DNA samples using Cross-pool tailcurve analysis
Authors: Tejasvi S Niranjan, Abby Adamczyk, Héctor Corrada Bravo, Margaret A Taub, Sarah J Wheelan, Rafael Irizarry, Tao Wang
Journal: Genome biology (2011)

Abstract Sequencing targeted DNA regions in large samples is necessary to discover the full spectrum of rare variants. We report an effective Illumina sequencing strategy utilizing pooled samples with novel quality (Srfim) and filtering ( SERVIC 4 E ) algorithms. We sequenced 24 exons in two cohorts of 480 samples each, identifying 47 coding variants, including 30 present once per cohort. Validation by Sanger sequencing revealed an excellent combination of sensitivity and specificity for variant detection in pooled samples of both cohorts as compared to publicly available algorithms.
Dermatologie und Venereologie; einschliesslich Berufskrankheiten, dermatologischer Kosmetik und Andrologie. In fünf Bänden. Band V, Teil I.
Authors: Stephen Rothman
Journal: JAMA (1963)

Gottron and Schoenfeld, distinguished senior German dermatologists, have undertaken the difficult task of presenting all modern knowledge in dermatology and venereal diseases in the restricted space of five volumes. By now, four of the five volumes consist of two separate parts, each part being a good-sized volume in itself. The material in the present "half-volume" is arranged in a haphazard fashion. General chapters written by Schirren, Kimmig, and Wehrmann give excellent, short, concise descriptions of the chemistry and the physiological functions of vitamins, hormones, and enzyme systems. However, the discussion of how these normal metabolites can be used in dermatological therapy is loaded with an immense number of references without sufficient cautioning that many of the cited claims are based on uncontrolled observations and badly need confirmation. A virtue of the three chapters, however, is the emphasis on side effects and warnings against overdosage. It is regrettable that many important
Abstract 4072: Overexpression of FOXO1 increased sensitivity to Tamoxifen in MCF7 cells, and is associated with estrogen receptor α (ERα) expression
Authors: Xiying Shang, Yanyuan Wu, Marianna Sarkissyan, H Phillip Koeffler, Jaydutt V. Vadgama
Journal: Cancer Research (2010)

Abstract The transcription factor FOXO1, which belongs to the Forkhead family, plays an important role in promoting cellular apoptosis in cancer cells. Clinical data from our laboratory suggested that breast cancer subtypes vary in their FOXO1 expression, and this difference may contribute to differential response to drug therapy. Our goal is to investigate the mechanisms associated with FOXO1 expression and anti-estrogen therapy in ERα positive breast cancer cells (MCF7 cells). First, we examined the FOXO1 expression in different Akt transfected clones, and the results showed that FOXO1 expression decreased in MCF7/AA cells (active Akt), but significantly increased in MCF7/DN cells (dominant negative Akt). Next, we examined FOXO1 expression in the Tamoxifen resistant cells (MCF7/TAMR cells). FOXO1 expression decreased in MCF7/TAMR cells, compared to MCF7/wildtype cells. To further explore the association between FOXO1 expression and the response to Tamoxifen in MCF7 cells, we established FOXO1 overexpression clones (MCF7/FOXO1), and checked the cell growth rate under Tamoxifen treatment. The results showed that MCF7/FOXO1 cells had better response to Tamoxifen, when compared with the vector transfected cells (MCF7/pcDNA3). Since Tamoxifen is an antagonist of the ERα receptor, we examined the relationship between ERα and FOXO1. We used the ERα knockdown cells (MCF7/antisense hERα cells) as a model, and found the high Akt, but low FOXO1 expression in these cells. In summary, our study demonstrates that FOXO1 is inversely related to Akt and ERα and improves sensitivity of Tamoxifen treatment in MCF7 breast cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4072.
Philip Morris and National Archives Light-Up Bill of Rights
Authors: Karen Broder, Tim Hensley
Journal: JNCI Journal of the National Cancer Institute (1990)

Journal Article Philip Morris and National Archives Light-Up Bill of Rights Get access Karen Broder, Karen Broder Search for other works by this author on: Oxford Academic PubMed Google Scholar Tim Hensley Tim Hensley Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 82, Issue 1, 3 January 1990, Pages 8–9, https://doi.org/10.1093/jnci/82.1.8 Published: 03 January 1990
Conscious will in the absence of ghosts, hypnotists, and other people
Authors: Johannes Schultz, Natalie Sebanz, Chris Frith
Journal: Behavioral and Brain Sciences (2004)

We suggest that certain experiences reported by patients with schizophrenia show that priority, consistency, and exclusivity are not sufficient for the experience of willing an action. Furthermore, we argue that even if priority, consistency, and exclusivity cause the experience of being the author of an action, this does not mean that conscious will is an illusion.
Interleukin-18 Enhances Antigen-induced Eosinophil Recruitment into the Mouse Airways
Authors: KOTARO KUMANO, ATSUHITO NAKAO, HIROSHI NAKAJIMA, FUMIAKI HAYASHI, MASASHI KURIMOTO, HARUKI OKAMURA, YASUSHI SAITO, ITSUO IWAMOTO
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Interleukin-18 (IL-18) has recently been identified as an IFN- γ -inducing factor. Previous studies have shown that CD4+ T cells, IL-5, and TNF- α mediate, but IFN- γ and IL-12 (via IFN- γ production) inhibit antigen-induced eosinophil recruitment into the airways of sensitized mice. Here, we showed that the administration of recombinant murine IL-18 enhanced antigen-induced eosinophil recruitment into the trachea and bronchoalveolar lavage fluids (BALF) of sensitized mice in a dose-dependent manner. The administration of IL-18 enhanced antigen-induced IFN- γ and TNF- α production, but not IL-5 production, in the BALF and lungs of sensitized mice. Neutralizing antibody against TNF- α prevented antigen-induced eosinophil recruitment into the BALF of sensitized mice. Although IL-18 enhanced antigen-induced airway eosinophilia, IL-18 did not affect antigen-induced airway hyperresponsiveness in sensitized mice. These results indicate that IL-18, unlike IFN- γ and IL-12, enhances antigen-induced eosinophil recruitment into the airways in part by increasing antigen-induced TNF- α production of sensitized animals. These findings suggest that IL-18 may contribute to the development and exacerbation of airway inflammation in asthma.
Lifestyle change helped to halve number of Americans dying from heart disease
Authors: M. Day
Journal: BMJ (2010)

Americans have halved their risk of dying from coronary heart disease in just 20 years largely by smoking less, monitoring blood cholesterol, and treating high blood pressure, a major survey indicates.

While treating existing heart disease also helped reduce mortality, prevention played by far the biggest part, says new research in the American Journal of Preventive Medicine (doi:10.1016/j.amepre.2010.05.009).

The researchers gathered data on total cholesterol concentrations, systolic blood pressure, and smoking prevalence from the national health and nutrition examination survey, a yearly poll representing the entire US population, with data taken from 1980 through to 2000. They entered those statistics into a modelling system …
997 FULMINANT HEPATITIS LISTED FOR EMERGENCY LIVER TRANSPLANTATION IN FRANCE – EPIDEMIOLOGY AND OUTCOME
Authors: P. Ichai, J. Belghiti, K. Boudjema, O. Boillot, C. Ducerf, B. Suc, P. Wolf, F.-R. Pruvot, O. Soubrane, Y.-P. Le Treut, D. Cherqui, L. Hannoun, G.-P. Pageaux, J. Gugenheim, C. Letoublon, L. Chiche, J. Saric, G. Mantion, J. Chipponi, D. Castaing, C. Antoine, D. Samuel
Journal: Journal of Hepatology (2013)
Abstract LB-282: Loss of PTP-PEST promotes tumor invasion, apoptosis resistance and activation of STAT3 in metastatic colon cancer.
Authors: Rosario Espejo, Yowjiun Jeng, Camille Johnson, Russ Carmical, Allan Brasier, Celia Chao, Sarita K. Sastry
Journal: Cancer Research (2013)

Abstract The transcription factor STAT3 is hyperactivated by phosphorylation on Y705 in over 75% of metastatic colon cancers and is associated with EMT, cancer stem cells, survival and chemoresistance. However, the mechanisms of STAT3 inactivation are not well-defined. Here, we identified the protein tyrosine phosphatase, PTP-PEST, as a novel negative regulator of STAT3 in colon carcinoma cells. Using lentiviral-mediated shRNA silencing of PTP-PEST in HCT116 colon carcinoma cells, we show that PTP-PEST knockdown enhances activation of STAT3. Whereas STAT3 is activated by cell attachment to collagen in control cells expressing non-targeting shRNA, PTP-PEST knockdown leads to constitutive, anchorage-independent STAT3 activity. Silencing of PTP-PEST enhances anchorage-independent survival in soft agar, tumor sphere growth and matrigel invasion in vitro. Consistent with increased invasion and survival, PTP-PEST knockdown cells showed enhanced expression of STAT3 target genes, MMP2 and mcl-1. Significantly, PTP-PEST knockdown enhanced apoptosis resistance in three-dimensional matrigel cultures in response to the chemotherapy drug, 5-fluorouracil (5-FU). PTP-PEST knockdown cells treated with 5-FU in 3-D matrigel spheroid cultures showed increased cell viability, reduced caspase-3 activation and enhanced activation of STAT3 relative to non-targeting controls. Furthermore, in subcutaneous nude mouse xenografts, although overall tumor growth was not affected by PTP-PEST knockdown, immunohistochemistry showed reduced caspase-3 and elevated P-STAT3 levels in these tumors. Intrasplenic injection of PTP-PEST knockdown cells in athymic nude mice resulted in enhanced metastatic potential as assessed by quantitative PCR for human DNA content in mouse liver. Finally, reduced PTP-PEST expression correlates with metastasis in clinical specimens from colon cancer patients. Taken together, these findings suggest that down-regulation of PTP-PEST in colon cancer may promote metastasis through increased invasion and apoptosis resistance, mediated, in part, by enhanced activation of STAT3. Citation Format: Rosario Espejo, Yowjiun Jeng, Camille Johnson, Russ Carmical, Allan Brasier, Celia Chao, Sarita K. Sastry. Loss of PTP-PEST promotes tumor invasion, apoptosis resistance and activation of STAT3 in metastatic colon cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-282. doi:10.1158/1538-7445.AM2013-LB-282
HemoQuant, A New Quantitative Assay for Fecal Hemoglobin
Authors: D. A. AHLQUIST
Journal: Annals of Internal Medicine (1984)

HemoQuant, an assay based on heme-derived porphyrin, quantifies both total fecal hemoglobin and that fraction already converted to porphyrin by gut flora (the intestinal converted fraction). Recovery by HemoQuant of blood added to stools exceeded 99% and was not affected by ascorbic acid, iron, or other additives. HemoQuant was used to evaluate the performance of Hemoccult on 1018 stools. Hemoccult sensitivity differed widely, remaining negative with up to 42.5 mg hemoglobin per gram of stool (about 43 mL/d of blood) but positive with only 0.04 mg of hemoglobin per gram of stool. Driest stools tended to be Hemoccult-negative and the wettest Hemoccult-positive. Hemoccult-negative stools became positive after aqueous dilution independent of hemoglobin concentration. The intestinal converted fraction, not detected by guaiac tests, often constituted most of the fecal hemoglobin equivalents and was significantly higher in Hemoccult-negative than in Hemoccult-positive stools. Hemoccult lost reactivity during fecal storage due to progressive heme degradation. Frequent false-negative and false-positive reactions of Hemoccult were explained largely by variations in stool liquidity and heme degradation.
Arteriotomy for Catheterization of the Left Side of the Heart in Children
Authors: George S. Husson, Marie S. Blackman
Journal: New England Journal of Medicine (1963)

LESIONS of the left side of the heart, both congenital and acquired, demand precise physiologic and anatomic diagnosis for accurate surgical relief. This is especially true in infants and children. The development of technics for catheterization of the left side of the heart has made such a goal possible.1 Percutaneous intubation of a cardiac catheter in the adult preserves the integrity of the artery. In infants and children this is not always possible because of the small size of the arterial lumen. Cutdown and exposure of the brachial or superficial femoral artery is usually necessary. Direct transverse or longitudinal . . .