HUMAN AUTONOMIC PHARMACOLOGY
Authors: JULIUS LOMAN
Journal: Annals of Internal Medicine (1939)

Article1 February 1939HUMAN AUTONOMIC PHARMACOLOGYXV. THE EFFECT OF ACETYL-BETA-METHYLCHOLINE CHLORIDE (MECHOLYL) BY IONTOPHORESIS ON ARTERIAL HYPERTENSION*JULIUS LOMAN, M.D., MARK FALCON LESSES, M.D., ABRAHAM MYERSON, M.D.JULIUS LOMAN, M.D.Search for more papers by this author, MARK FALCON LESSES, M.D.Search for more papers by this author, ABRAHAM MYERSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-12-8-1213 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn previous experiments1, 2 on the pharmacology of the autonomic nervous system, it was found that the blood pressure elevation produced by benzedrine sulfate (benzylmethyl carbinamine or beta-phenyl-isopropylamine) was quickly lowered by an injection of mecholyl (acetyl-beta-methylcholine chloride). This effect was of short duration, the blood pressure quickly resuming the high level produced by the benzedrine.In the present study, our aim was to compare the blood pressure lowering effect of mecholyl iontophoresis on benzedrine-induced hypertension and on senile hypertension.The technic of mecholyl iontophoresis has been described by many authors, including ourselves.3, 4, 5, 6, 7The drug is...References1. MYERSONLOMANDAMESHEK AJW: Physiologic effects of benzedrine and its relationship to other drugs affecting the autonomic nervous system, Am. Jr. Med. Sci., 1936, cxcii, 560-574. CrossrefGoogle Scholar2. MYERSONLOMANDAMESHEK AJW: Physiologic effects of acetyl-beta-methylcholine (mecholyl) and its relationship to other drugs affecting the autonomic nervous system, Am. Jr. Med. Sci., 1937, cxcii, 198. CrossrefGoogle Scholar3. LOMANRINKELMYERSON JMA: Human autonomic pharmacology. VIII. The effect of iontophoresis on the gastric juices with especial reference to acetyl-beta-methylcholine chloride (mecholyl), Am. Jr. Digest. Dis. and Nutr., 1937, iv, 386-390. CrossrefGoogle Scholar4. KOVACS J: Iontophoresis of acetyl-beta-methylcholine chloride in treatment of chronic arthritis and peripheral vascular disease, Am. Jr. Med. Sci., 1934, clxxxviii, 32. CrossrefGoogle Scholar5. KOVACSKOVACS RJ: Newer aspects of iontophoresis for arthritis and circulatory disturbances, Arch. Phys. Therap., 1934, xv, 593-598. Google Scholar6. KRAMER DW: The use of acetyl-beta-methylcholine chloride by iontophoresis in peripheral vascular diseases, Am. Jr. Med. Sci., 1937, cxciii, 405-413. CrossrefGoogle Scholar7. MATHAE GH: The treatment of arthritis with mecholyl iontophoresis; report of cases, Jr. Missouri Med. Assoc., 1936, xxxiii, 303-317. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Mattapan, Massachusetts*Received for publication November 13, 1937.From the Division of Psychiatric Research, Boston State Hospital, Mattapan, Mass., aided by grants from the Commonwealth of Massachusetts and the Rockefeller Foundation. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAllgemeine ÜbersichtenPharmakologie und vegetatives Nervensystem 1 February 1939Volume 12, Issue 8Page: 1213-1222KeywordsAutonomic nervous systemBlood pressureChloridesDrugsHypertensionPharmacologySulfates Issue Published: 1 February 1939 PDF DownloadLoading ...