PROBLEMS IN THE CORTICOSTEROID THERAPY OF RHEUMATIC DISEASE
Authors: W BLECHMAN, J H VAUGHAN
Journal: Annals of Internal Medicine (1959)

Article1 March 1959PROBLEMS IN THE CORTICOSTEROID THERAPY OF RHEUMATIC DISEASEWILBUR BLECHMAN, M.D., JOHN H. VAUGHAN, M.D.WILBUR BLECHMAN, M.D.Search for more papers by this author, JOHN H. VAUGHAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-3-571 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHench and his co-workers1 introduced cortisone as a therapeutic agent for the treatment of rheumatic diseases in 1949. Since then this hormone and related derivatives have been extensively used, and their clinical values and limitations have been more fully described.Although the mechanism of corticosteroid antiphlogistic effect has not been well defined, several observations give us hints as to possible pathways for this action. A general depressant effect of corticosteroids upon nitrogen metabolism can often be demonstrated as a negative nitrogen balance. Instances of suppressed cell function, such as the impaired ability of phagocytes to dispose of ingested particles,2suppressed...Bibliography1. HenchKendallSlocumbPolley PSECCHHF: The effect of a hormone of the adrenal cortex, (17-hydroxy-11-dehydro-corticosterone; Compound E) and of pituitary adreno-corticotrophic hormone on rheumatoid arthritis, Proc. Staff Meet., Mayo Clin. 24: 181, 1949. MedlineGoogle Scholar2. LurieZappasodiDannenbergCardona-Lynch MBPAME: The effect of cortisone and ACTH on the pathogenesis of tuberculosis, Ann. New York Acad. Sc. 56: 779, 1953. CrossrefMedlineGoogle Scholar3. Fischel EE: Hypersensitivity and the hyperadrenal state, in Conference on the connective tissue, edited by C. Ragan, 1952, Josiah Macy, Jr. Foundation, New York. Google Scholar4. 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TalbottFerrandis JHRM: Collagen diseases, 1956, Grune and Stratton, New York. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication May 21, 1958.From the Connective Tissue Study Group of the Department of Medicine, Medical College of Virginia, Richmond, Virginia.Supported in part by Research Grant U. S. Public Health Service A-700 of the National Institutes of Health, and by a grant from the Virginia Chapter, Arthritis and Rheumatism Foundation, and the A. D. Williams Fund, Medical College of Virginia, Richmond, Virginia.Requests for reprints should be addressed to John H. Vaughan, M.D., Associate Professor of Medicine, The University of Rochester School of Medicine and Dentistry, 260 Crittenden Boulevard, Rochester 20, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byProphylaxis in patients receiving adrenal steroid therapyRheumatism and Arthritis Review of American and English Literature of Recent Years (Fourteenth Rheumatism Review)CHARLEY J. SMYTH, M.D., F.A.C.P., ROGER L. BLACK, M.D., CHARLES L. CHRISTIAN, M.D., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., EDWARD C. FRANKLIN, M.D., DONALD F. HILL, M.D., F.A.C.P., JOSEPH L. HOLLANDER, M.D., F.A.C.P., HOWARD L. HOLLEY, M.D., F.A.C.P., JOHN G. MAYNE, M.D., WILLIAM M. MIKKELSEN, M.D., CHARLES L. SHORT, M.D., F.A.C.P., HUGH A. SMYTHE, M.D., F.R.C.P.(C), OTTO STEINBROCKER, M.D., HOWARD J. WEINBERGER, M.D.The Use and Abuse of the Corticosteroid Hormones in Connective Tissue Diseases 1 March 1959Volume 50, Issue 3Page: 571-585KeywordsCorticosteroid therapyHemorrhageHormonesMedical servicesNeutrophilsNitrogen metabolismOsteoporosisPhagocytesPsychosesResearch grants ePublished: 1 December 2008 Issue Published: 1 March 1959 PDF downloadLoading ...