Myocardial Infarction during Cocaine Withdrawal
Authors: Cesar Del Aguila
Journal: Annals of Internal Medicine (1990)

Letters and Corrections1 May 1990Myocardial Infarction during Cocaine WithdrawalCesar Del Aguila, MD, Howard Rosman, MDCesar Del Aguila, MDSearch for more papers by this author, Howard Rosman, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-9-712_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor: Nademanee and colleagues (1) demonstrated ST segment changes of silent ischemia during Holter monitoring in 8 of 21 chronic cocaine abusers who had stopped taking the drug an average of 8.5 days before testing. These patients had normal exercise treadmill tests and were presumed free of significant coronary atherosclerosis. The authors of this interesting study proposed the dopamine depletion hypothesis to explain the coronary vasoconstriction (spasm) observed in these subjects. We report a case of myocardial infarction during cocaine withdrawal and postulate an alternative hypothesis to explain this phenomenon.A 42-year-old male chronic cocaine (crack) smoker was...References1. NademaneeGorelickJosephson KDM. Myocardial ischemia during cocaine withdrawal. Ann Intern Med. 1989;111:876-80. LinkGoogle Scholar2. FrishmanKarpenosMolloy WAT. Cocaine-induced coronary artery disease: recognition and treatment. Med Clin North Am. 1989; 73:475-86. CrossrefMedlineGoogle Scholar3. DackisGold CM. New concepts in cocaine addiction: the dopamine depletion hypothesis. Neurosci Biobehav Rev. 1985;9:1-9. CrossrefGoogle Scholar4. Langer S. Presynaptic regulation of the release of catecholamines. Pharmacol Rev. 1980;32:337-62. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Cesar Del Aguila, MD; Howard Rosman, MDAffiliations: Henry Ford Hospital Detroit, MI 48202-2689 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCocaineCocaineSpectrum of electrocardiographic and angiographic coronary artery disease findings in patients with cocaine-associated myocardial infarctionCocaïneEvaluation and Management of the Patient Who Has Cocaine-associated Chest PainCocaineIncreased TIMI frame counts in cocaine users: A case for increased microvascular resistance in the absence of epicardial coronary disease or spasmCOCAINE USE AND ACUTE MYOCARDIAL INFARCTIONThe disposition of benzoylecgonine in maternal and fetal ratsEVALUATION OF PATIENTS WITH CHEST PAIN AFTER COCAINE USEEphedrine-Induced Coronary Artery Vasospasm in a Patient with Prior Cocaine UseEphedrine-Induced Coronary Artery Vasospasm in a Patient with Prior Cocaine UsePredictors of Coronary Artery Disease in Patients With Cocaine-associated Myocardial InfarctionClinical Policy for the Initial Approach to Adults Presenting With a Chief Complaint of Chest Pain, With No History of TraumaProspective Multicenter Evaluation of Cocaine-associated Chest PainCocaine Metabolites in the Neonate: Potential for Toxicity“Abnormal” electrocardiograms in patients with cocaine-associated chest pain are due to “normal” variantsCocaine-induced myocardial infarction: An analysis and review of the literatureCardiovascular Complications of Cocaine AbuseThe cardiovascular effects of cocaine 1 May 1990Volume 112, Issue 9Page: 712-712KeywordsAddictsCocaineDopamineExerciseIschemiaMyocardial infarctionPatientsStable coronary artery diseaseTherapeutic drug monitoringVasoconstriction ePublished: 1 December 2008 Issue Published: 1 May 1990 PDF downloadLoading ...