MASSIVE NECROSIS OF THE LIVER FOLLOWING IPRONIAZID
Authors: H SHAY, D C SUN
Journal: Annals of Internal Medicine (1958)

Case Reports1 November 1958MASSIVE NECROSIS OF THE LIVER FOLLOWING IPRONIAZIDHARRY SHAY, M.D., F.A.C.P., DAVID C. H. SUN, M.D., D.SC. (Med.)HARRY SHAY, M.D., F.A.C.P., DAVID C. H. SUN, M.D., D.SC. (Med.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-5-1246 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe hydrazine derivatives of isonicotinic acid (isoniazid and iproniazid) have been used effectively in the treatment of human tuberculosis. However, significant side-effects have occurred in patients under treatment with these compounds, particularly with iproniazid.1-4 These included euphoria, nervousness, restlessness, involuntary muscle twitching, hyperreflexia and mild clonus, peripheral neuritis, headache and vertigo. Occasionally, progressive hemolytic anemia and orthostatic hypotension with syncope have been reported from the use of iproniazid.5Iproniazid phosphate, 1-isonicotinyl-2-isopropyl-hydrazine phosphate, has recently been suggested as a "psychic energizer," to restore a feeling of well-being, to promote increase in appetite, weight and vitality, and for use in patients with...Bibliography1. RobitzekSelikoffOrnstein EHIJGG: Chemotherapy of human tuberculosis with hydrazine derivatives of isonicotinic acid, Quart. Bull., Sea View Hosp. 13: 27, 1952. Google Scholar2. SelikoffRobitzek IJEH: Tuberculosis chemotherapy with hydrazine derivatives of isonicotinic acid, Dis. of Chest 21: 385, 1952. CrossrefMedlineGoogle Scholar3. CoatesBrickmanMeade EOGLGM: Toxicity of isonicotinic acid hydrazides in pulmonary tuberculosis, Arch. Int. Med. 93: 541, 1954. CrossrefGoogle Scholar4. O'ConnorHowlettWagner JBKSRR: Side effects accompanying use of iproniazid, Am. Rev. Tuberc. 68: 270, 1953. MedlineGoogle Scholar5. SelikoffRobitzekOrnstein IJWHGG: Toxicity of hydrazine derivatives of isonicotinic acid in chemotherapy of human tuberculosis, Quart. Bull., Sea View Hosp. 13: 17, 1952. Google Scholar6. DeVerteuilLehmann RLHE: Therapeutic trial of iproniazid (Marsilid) in depressed and apathetic patients, Canad. M. A. J. 78: 131, 1958. MedlineGoogle Scholar7. Ayd FJ: A preliminary report on Marsilid, Am. J. Psychiat. 114: 459, 1957. CrossrefMedlineGoogle Scholar8. ZellerBarskyFoutsKirscheimerVan Orden EAJJRWFLS: Influence of isonicotinic acid hydrazide (INH) and 1-isonicotinyl-2-isopropylhydrazine (IIH) on bacterial and mammalian enzymes, Experientia 8: 349, 1952. CrossrefGoogle Scholar9. UdenfriendWeissbachBogdanski SHDF: Biochemical findings relating to the action of serotonin, Ann. New York Acad. Sc. 66: 602, 1957. CrossrefMedlineGoogle Scholar10. BralowShay PH: Serial biochemical and histological observations in a case of hepatitis following iproniazid, to be published. Google Scholar11. UmbreitKingsleySchoffertSiplet WWGRRRH: A colorimetric method for transaminase in serum or plasma, J. Lab. and Clin. Med. 49: 454-459, 1957. MedlineGoogle Scholar12. ShaySiplet HH: Study of chlorpromazine jaundice, its mechanism and prevention. Special reference to serum alkaline phosphatase and glutamic oxalacetic transaminase, Gastroenterology 32: 571, 1957. CrossrefMedlineGoogle Scholar13. Floody RJ: Personal communication. Google Scholar14. Popper H: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication June 18, 1958.From the Samuel S. Fels Research Institute, Temple University Medical Center, Philadelphia, Pennsylvania.Requests for reprints should be addressed to Harry Shay, M.D., Fels Research Institute, Temple University Medical Center, Philadelphia 40, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIproclozide fulminant hepatitisCytologic and Histologic Aspects of Toxically Induced Liver ReactionsOn Potential Carcinogenicity of Some Hydrazine Derivatives Used as DrugsTumour-inducing Effect of Hydrazine in MiceTHE HISTOPATHOLOGY OF DRUG-INDUCED LIVER DISEASEA Controlled Trial of Phenelzine ("Nardil") in the Treatment of Severe Depressive IllnessTreatment of Depression by Drugs and Other MeansMonoaminoxydase-HemmerDRUG-INDUCED HEPATIC INJURY*HANS POPPER, M.D., F.A.C.P., FENTON SCHAFFNER, M.D., F.A.C.P.Jaundice following iproniazid administration with recoveryLiver-function tests in patients receiving iproniazidLiver disease 1 November 1958Volume 49, Issue 5Page: 1246-1252KeywordsComaHypotensionIsoniazidLiverMusclesNecrosisPatientsPhosphatesSyncopeVertigo ePublished: 1 December 2008 Issue Published: 1 November 1958 PDF downloadLoading ...