tbuckley/cabot-search huggingface dataset:
Psychiatric consultation in severe and profound mental retardation
Authors: B H King, C DeAntonio, J T McCracken, S R Forness, V Ackerland
Journal: American Journal of Psychiatry (1994)

This study was designed to examine the relationship between reason for referral and subsequent DSM-III-R diagnosis in institutionalized individuals with severe to profound mental retardation. A heavy emphasis was placed on articulating how diagnostic criteria are applied in this population.The study population consisted of 251 patients consecutively referred for initial psychiatric consultation from a large series of institutionalized patients with predominately severe to profound mental retardation. On the basis of the chief complaint, subjects could be grouped into six overlapping categories: self-injury, aggression, hyperactivity, agitation, medical questions, and miscellaneous behaviors. Psychiatric diagnoses were made according to DSM-III-R criteria on the basis of simultaneous clinical examination, staff interview, and medical review. Relevant medical conditions were noted.The authors demonstrate, as have others, that it is possible to make psychiatric diagnoses in this population and that psychiatric disorder is common. The most frequent diagnoses were impulse control disorders, anxiety disorders, and mood disorders. Comorbid medical conditions, particularly seizure disorders, are also common.These results are consistent with the reported experience of others and underscore the importance of psychiatric involvement in the multidisciplinary assessment and treatment of individuals with retardation.
Abstract 12657: PET Imaging of Fatty Acid Oxidation and Glucose Uptake in Heart and Skeletal Muscle of Rats: Effects of CPT-1 Inhibition
Authors: Mukesh K Pandey, Falguni Bhattacharyya, Anthony P Belanger, Shuyan Wang, Timothy R DeGrado
Journal: Circulation (2010)

Fatty acid oxidation (FAO) is a major energy-producing process in heart (H) and skeletal muscle (SM) that has critical importance in coronary heart disease, heart failure, cardiomyopathies, obesity...
Abstract 562: A New Method for Evaluating Renal Artery Stenosis and Coronary Artery Disease by Multislice Computed Tomography
Authors: Yoshihiro Takeda, Masaaki Hoshiga, Tomohiro Fujisaka, Junko Hotchi, Takahito Yuki, Fuminari Tatsugami, Tadashi Ishihara, Yoshifumi Narumi, Toshiaki Hanafusa
Journal: Circulation (2009)

(Background) Renal artery stenosis (RAS) is most frequently due to atherosclerosis and is associated with coronary artery disease (CAD) and aortic atheroma. Recently multislice computed tomography (MSCT) has remarkably progressed and it is recommended for noninvasive diagnosis of RAS. Variable pitch helical scanning (VPHS) method can scan cardiac (narrow pitch, ECG gated) and abdominal (wide pitch, non ECG gated) area within one scanning. Thus this method enables us to screen CAD and RAS noninvasively at a time. The aim of this study was to investigate the frequency of RAS using VPHS with MSCT and to find the predictors for RAS. (Methods) Consecutive 354 patients (male 57%, mean age 67 y.o.) who were suspected of CAD and planned for MSCT (Aquilion 64, Toshiba Medical Systems) were enrolled in this study. VPHS method was used in all patients. The patients with renal insufficiency (serum creatinine > 1.5mg/dl) were excluded. Traditional risk factors and estimated creatinine clearance (eCcr) calculated by th...
Abstract 4567: Functional Intraoperative Pulmonary Blood Flow Study is a Sensitive Predictor of Right Ventricular Pressure and Successful VSD Closure for Following Complete Uniforcalization in Patients with Pulmonary Atresia with Ventricular Septal Defect and Major Aortopulmonary Collaterals
Authors: Osami Honjo, Osman O Al-Radi, Cathy MacDonald, Lisa Davey, Christopher A Caldarone, Glen S Van Arsdell
Journal: Circulation (2008)

OBJECTIVE: We hypothesized mean pulmonary artery (PA) pressure obtained from an intraoperative pulmonary flow study would better predict the ability to close the ventricular septal defect (VSD) and better predict postoperative right ventricular systolic pressure (RSVP) than classic anatomical parameters after complete uniforcalization in patients with pulmonary atresia, VSD, and major aortopulmonary collaterals. METHODS: Sixteen consecutive patients (median, 11 mo, range 2 mo – 16 yrs) underwent one-stage (75%) or staged (25%) uniforcalization between 1/03 and 8/07. Intraoperative functional pulmonary blood flow study was achieved by inserting an arterial cannula in a reconstructed central PA. Flow was increased to 2.5 L/min/m2 while measuring PA pressure. RVSP and systemic systolic pressure (SBP) were recorded after VSD closure. Total neopulmonary artery index (TNPAI) (MAPCA + native PA index), total incorporated pulmonary vascular segments, and pulmonary segment artery ratio (PSAR) (ratio of incorporated segment to 18) were analyzed. Spearman rank correlation and area under the receiver operator characteristics curve (ROC-AUC) were used. RESULTS: The mean PA pressure on flow study was 21.8+/−6.2 mmHg (range, 11–31). Three patients had a pressure of &gt; 30 mmHg. The VSD was closed in 14 (87%). One patient with flow study mean PA pressure of 25 mmHg had suprasystemic RVSP and underwent intraoperative VSD fenestration. One with a flow study mean PA pressure of 30 mmHg had a prospective fenestrated VSD patch placed. There is a weak negative correlation between TNPAI and the flow study PA pressure (rho=−0.4, p=0.12). The flow study mean PA pressure was correlated with post-repair RVSP (rho=0.72, p=0.0027), and with RVSP/SBP ratio (rho=0.67, p=0.0063). TNPAI, total incorporated segments, and PSAR were not correlated with the postoperative RVSP or RVSP/SBP ratio. Flow study mean PA pressure had the highest sensitivity in predicting VSD closure: ROC-AUC (0.82) vs. TNPAI (0.46), pulmonary segment (0.64), and PSAR (0.64). CONCLUSIONS: Intraoperative pulmonary flow study predicted the ability of VSD closure better than total incorporated segments, TNPAI, and PSAR. Flow study mean PA pressure highly correlated with postoperative RVSP and RVSP/SBP ratio.
Development and Involution of the Notochord in the Human Spine
Authors: U E Pazzaglia, J R Salisbury, P D Byers
Journal: Journal of the Royal Society of Medicine (1989)

The availability of a collection of fetal and embryonic spines made possible a review of the involution of the notochord. Results of this histological, histochemical and immunohistochemical study are in accord with the dominant view in the literature that the notochord does not contribute materially to the adult nucleus pulposus. It is also consonant with the expectation that, normally, all chordal cells have disappeared during early childhood, but is not sufficiently detailed to assess the possibility of occasional survivors.
Abstract 11384: Evaluation of Left Ventricular Systolic Function by Magnetic Resonance Imaging in Patients with Multiple Myeloma and Cardiac Amyloidosis Receiving Autologous Bone Marrow Transplantation
Authors: Sameer Raina, Abhishek Deshmukh, Kedar Jambhekar, Jawahar L Mehta
Journal: Circulation (2011)

BACKGROUND/AIMS: Cardiac MRI has evolved as a sensitive imaging technique for detecting cardiac amyloidosis as well as left ventricular (LV) function. We assessed LV systolic function in patients w...
Pharmacist Care for Reactive Airway Disease
Authors: Ricky T. Guidry
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CPT-11-induced cholinergic effects in cancer patients.
Authors: D Gandia, D Abigerges, J P Armand, G Chabot, L Da Costa, M De Forni, A Mathieu-Boue, P Herait
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.1.196 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8418235 CPT-11-induced cholinergic effects in cancer patients. D GandiaxD GandiaSearch for articles by this author , D AbigergesxD AbigergesSearch for articles by this author , J P ArmandxJ P ArmandSearch for articles by this author , G ChabotxG ChabotSearch for articles by this author , L Da CostaxL Da CostaSearch for articles by this author , M De FornixM De ForniSearch for articles by this author , A Mathieu-BouexA Mathieu-BoueSearch for articles by this author , P HeraitxP HeraitSearch for articles by this author Show More https://doi.org/10.1200/JCO.1993.11.1.196 PDF "CPT-11-induced cholinergic effects in cancer patients.." Journal of Clinical Oncology, 11(1), pp. 196–197© 1993 by American Society of Clinical Oncology
Abstract 4234: Prognostic Implication of the Continuous Prognostic Spectrum of Coronary Flow Reserve in Patients with and without Angiographically Obstructive Coronary Artery Disease
Authors: Lauro Cortigiani, Fausto Rigo, Sonia Gherardi, Rosa Sicari, Maria Luisa Gianfaldoni, Maurizio Galderisi, Francesco Bovenzi, Eugenio Picano
Journal: Circulation (2008)

Dual imaging of wall motion and coronary flow reserve (CFR) on left anterior descending (LAD) artery is now the state-of-the art technique for vasodilator stress echo. The additive prognostic value of CFR over regional wall motion has been established, but there is more than a binary (normal-abnormal ) response in CFR, which can be continuously titrated. Objectives. To assess the prognostic value of Doppler echocardiographic derived CFR in patients with and without angiographically obstructive coronary artery disease (CAD). 1244 patients (785 men, age 64±11 yy) with known or suspected CAD underwent dipyridamole (up to 0.84 mg/kg over 6′) stress echo with CFR evaluation of left anterior descending artery by Doppler and coronary angiography. Patients were followed-up for a median of 17 months. Mean CFR in the entire population was 2.25±0.64. During follow-up, there were 227 events (26 deaths, 55 STEMI, and 146 NSTEMI). Patients (n=384) undergoing revascularization were censored. Using the Kaplan-Meier method, the lowest quartile of CFR (&lt;1.80) was associated with a significantly (p&lt;0.0001) worst event rate than other quartiles (Figure ), both considering the group with (83 vs 53%, p&lt;0.0001) and without (53 vs 12%, p&lt;0.0001) obstructive CAD at angiography. CFR is a strong and independent prognostic predictor in patients with known or suspected CAD, but the spectrum of prognostic stratification is expanded if the response is titrated according to a continuous scale rather than artificially dichotomized.
Author’s reply to ElSayed and colleagues, Obeidalla, and Hamad
Authors: Duncan Gardham
Journal: BMJ (2015)

The articles about the publicity campaign to attract doctors to the Islamic State of Iraq and Syria (ISIS) and their success in attracting two groups of British doctors studying in Sudan, did not mean to imply that similar problems are not faced elsewhere.1 2

Some respondents cited figures showing Sudan does not appear in analysis on foreign fighters in Syria.3 Such analysis has been based largely on official figures and because the regime in Sudan has not published such figures it is difficult to know where they fall on the scale. More relevant to this article, 23 doctors from …
Abstract 1946: Regulation OF Entpdase1 (CD39) Expression by Fluid-phase Shear Forces
Authors: Matthew C Hyman, Chih-Wen Ni, Scott H Visovatti, Douglas Nam, Mithun K Neral, Hanjoong Jo, David J Pinsky
Journal: Circulation (2008)

Sudden death due to thrombotic occlusion of a ruptured plaque is the leading cause of mortality in patients with atherosclerosis. Little is known about how the apyrase ENTPDase1 (CD39), a primary regulator of platelet activation in vivo , is affected at the plaque surface. By examining coronal sections of atherosclerotic plaques from apoE −/− mice, we determined that CD39 is lost specifically in endothelium overlying the plaque surface, but not in adjacent endothelium. This led to the hypothesis that CD39 expression in the vascular wall may be driven by laminar, fluid-phase shear forces. To distinguish the effects of hyperlipidemia from that of shear forces, coronal aortic arch sections from wild type mice were examined at the greater curvature (an area defined by laminar shear stresses) and the ostia of the left subclavian artery (an area defined by non-laminar blood flow). Fluorescent intensity quantification revealed a near 6-fold induction of CD39 staining in areas exposed to laminar shear stresses. This finding was confirmed by confocal microscopy of en face aorta preparations as well. In vitro studies with human umbilical vein endothelial cells in a cone plate viscometer showed a 10.8-fold induction of CD39 mRNA by laminar shear stress (~15 dyne/cm 2 ) when compared to fluid stasis (p&lt;0.001). By comparison oscillatory flow (0 ± 5 dyne/cm 2 , 1 Hz) did not induce a significant change in CD39 mRNA when compared to static control. Western blotting revealed that the CD39 mRNA induced by laminar shear manifested as a more than 4.3-fold induction of protein (p&lt;0.01). Flow cytometry confirmed the western blotting results showing a 3.8-fold induction of CD39 protein on the surface of cells exposed to laminar shear. These are the first data to show that CD39 is regulated by shear, and that it is lost from endothelium overlying atherosclerotic plaque in regions of turbulent flow. These results could be of great clinical relevance as they demonstrate that CD39, the enzyme that prevents aberrant platelet activation, is lost on the plaque surface. These data support the hypothesis that regional vascular zones are athero- and thrombo-resistant due to local ectonucleotidase expression modulated by dynamic/shear forces in flowing blood. This research has received full or partial funding support from the American Heart Association, AHA Midwest Affiliate (Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, South Dakota &amp; Wisconsin).
Cutaneous Manifestations Of Autoimmune Disease
Authors: J L Callaway
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antiplatelet therapy for thromboprophylaxis: the need for careful consideration of the evidence from randomised trials
Authors: R Collins, C Baignent, P Sandercock, R Peto
Journal: BMJ (1994)

cations must surely be discarded.Equally, an overview which clearly states that it has used data from studies in which comparison of bleeding was not possible and then makes recommendations for clinical practice must be viewed with great caution.In conclusion, we believe the following points should be made.Firstly, it is time to define the minimum criteria before including studies in a meta-analysis.Secondly, at present there is insufficient evidence to justify use of antiplatelet agents for thromboprophy- laxis.Thirdly, this meta-analysis has resulted in regressive recommendations which may lead to consideration of treatment with lesser efficacy and safety than currently available regimens with low dose heparins.Fourthly, in view of these serious reservations we suggest that the recommendations of the antiplatelet trialists are not put into practice.Finally, we agree that there is a need for well designed, large, blinded trials to compare antiplatelet and anticoagulant thromboprophylaxis.
Technical difficulties may have affected study's results
Authors: S. Barton, M. Cranney, T. Walley
Journal: BMJ (1996)

Table 1-Cost per life year gained with diuretic and 3 blocker treatment (thousands of Swedish crowns at 1992 prices; 10 Swedish crowns = £1).With permission3 Age (years) <45 45-69 ¢70 Diastolic blood pressure (mm Hg) Men Women Men Women
Abstract 19995: p22phox-Based Nox4 Regulates Cellular Survival by Modulating FOXO3A Activity and Sirt1 Expression
Authors: Lihong Cheng, Joshua D Lovelock, Atsuko Tanaka, Qianhong Qin, Calin Chiribau, George P Sorescu, David G Harrison, Dan Sorescu
Journal: Circulation (2010)

Fasting triggers a survival response coordinated by the transcription factor FOXO3A and histone deacetylase SIRT1 by controlling the expression of antioxidant enzymes. We hypothesized that the NADPH oxidase Nox4 regulates these responses via FOXO3A-SIRT1 activation. We first decreased Nox4 or FOXO3A levels in human cardiac fibroblasts (HCFB) and measured apoptotic response induced by serum deprivation. Transfection with siNox4 caused a □300% increase in cellular apoptosis in response to serum deprivation. This was associated with a corresponding 50% increase in cellular H2O2 production (n=7, p<0.05). We hypothesized that oxidative stress caused by depletion of Nox4 or FOXO3A is due to downregulation of the antioxidant enzymes. Quantitative PCR analysis showed that deletion of Nox4 leads to downregulation of antioxidant enzymes catalase, peroxiredoxin III (Prx III) and the anti-apoptotic bcl2 while it triggered the upregulation of the pro-apoptotic factor Bim and atrogin1 in HCFB. Furthermore, the apoptoti...
Abstract 17806: Sleep Quality and Duration are Associated with Higher Levels of Inflammatory Biomarkers: the META-Health Study
Authors: Alanna Morris, Dorothy Coverson, Lucy Fike, Yusuf Ahmed, Neli Stoyanova, W. Craig Hooper, Gary Gibbons, Donald Bliwise, Viola Vaccarino, Rebecca Din-Dzietham, Arshed Quyyumi
Journal: Circulation (2010)

Background: Growing evidence links sleep quality to CVD risk, and inflammation may be one mechanism by which sleep affects CVD outcomes. We sought to investigate the association of sleep quality an...
Abstract P21: Deletion of Caspase-2 Inhibits Ischemia/Reperfusion-induced Oxidant Burst and Apoptosis in Cardiomyocytes
Authors: Zuo-Hui Shao, Chang-Qing Li, Kim Wojcik, Lisa Hoffman, Yimin Qin, Terry Vanden Hoek, Kimm J Hamann
Journal: Circulation (2009)
Abstract 2880: Age Cutoff For The Loss Of Benefit From Bilateral Internal Thoracic Artery Grafting
Authors: Siamak Mohammadi, Francois Dagenais, Patrick Mathieu, Daniel Doyle, Richard Baillot, Jean Perron, Eric Charbonneau, Eric Dumont, Pierre Voisine
Journal: Circulation (2007)

Objectives : To identify the age-related benefit of single and bilateral internal thoracic artery (ITA) grafting on long-term cardiac-related survival in patients who survived from primary isolated coronary artery bypass grafting (CABG). Methods : A unicenter study was conducted on 12198 consecutive survivors from primary isolated CABG who received single (n=9533 patients) or bilateral (n=1388 patients) ITA grafts, or vein grafts only (n=1277 patients) between 1992 and 2005. Data was collected prospectively. The Cox regression model was used to estimate the hazard ratio of each independent variable on cardiac-specific survival over the entire length of follow-up. Age was a significant covariate into the statistical model. The mean follow-up was 5.7 ± 3.7 years and 100% complete as of December 2005. Results : After adjustments for different risk factors, the cardiac-related survival benefit in patients undergoing CABG with two ITAs was superior to that of single ITA grafting up to 60 years of age, displaying a constant decrease over time (Fig 1 ). The use of a single ITA was beneficial on cardiac-related survival in all age groups, including octogenarians, compared to patients receiving only vein grafts. Conclusions : The use of at least one ITA is associated with increased long-term cardiac-specific survival in all age groups compared to venous-only CABG. The additional cardiac-specific survival benefit of using a second ITA decreases gradually with age, and its statistical significance is lost after 60 years of age.
Abstract 195: Survival in Out-of-Hospital Cardiac Arrest Patients Without a Prehospital Return of Spontaneous Circulation
Authors: Ian Drennan, Steve Lin, Daniel Sidalak, Laurie J Morrison
Journal: Circulation (2012)

Background: Survival rates are low in out-of-hospital cardiac arrest (OHCA) patients transported without a prehospital return of spontaneous circulation (ROSC). Few studies have examined the patient characteristics and prehospital factors associated with improved survival in this unique cohort. Objective: This study aims to describe patient and prehospital factors associated with survival to hospital discharge when patients fail to achieve ROSC in the field. Methods: This was a retrospective observational study of consecutive adult (≥18 years) OHCA patients without a prehospital ROSC from December 1, 2005 to March 30, 2012 who were attended to and transported by emergency medical services (EMS) from urban and rural regions employing the current termination of resuscitation (TOR) guidelines. EMS witnessed cardiac arrests, and cardiac arrests of non-cardiac etiology were excluded. Bivariate analyses were used to determine associations of patient characteristics and prehospital variables with survival to hospital discharge. Results: There were 17,488 OHCA treated by EMS, with 4,892 (28.0%) transported to hospital without a prehospital ROSC. Of these patients, only 42 (0.86%) survived to hospital discharge. Survivors were often younger with initial shockable rhythms, had OHCA that were more often witnessed by bystanders and occurred in public locations, compared to non-survivors (table). No differences were noted in the proportion of male gender, bystander CPR rates, EMS response time, advanced airway, or ALS provider level. Three patients (0.06%) did not meet the criteria for transport in accordance with current TOR guidelines however were transported at the discretion of EMS and survived. Conclusion: Less than 1% (the threshold for futility) of OHCA patients without a prehospital ROSC survived to hospital discharge. Survival in this cohort was associated with younger age, shockable initial rhythms, bystander-witnessed arrests, and public location.