DEMEROL: A NEW SYNTHETIC ANALGETIC, SPASMOLYTIC AND SEDATIVE AGENT. I. PHARMACOLOGIC STUDIES
Authors: Fredrick F. Yonkman, Paul H. Noth, Hans H. Hecht
Journal: Annals of Internal Medicine (1944)

Article1 July 1944DEMEROL: A NEW SYNTHETIC ANALGETIC, SPASMOLYTIC AND SEDATIVE AGENT. I. PHARMACOLOGIC STUDIESFREDRICK F. YONKMAN, M.D., PAUL H. NOTH, M.D., M.S., HANS H. HECHT, M.D.FREDRICK F. YONKMAN, M.D.Search for more papers by this author, PAUL H. NOTH, M.D., M.S.Search for more papers by this author, HANS H. HECHT, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-1-7 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe disadvantages attending therapeutic use of morphine and other analgetics have impelled investigators in numerous fields of medical endeavor to seek an adequate substitute for the relief of pain. Codeine, dilaudid, snake venom and other agents recently introduced do not subscribe in every respect to the specification of 'adequate substitute' because of various side-effects or other disadvantages associated with each. However, a synthetic substance which in some respects equals or surpasses morphine is available in demerol. It appears in the literature under various names such as Dolantin, Dolantol, D-140, S-140, and more recently as Demerol, which is the most generally...Bibliography1. EISLEBSCHAUMANN OO: Dolantin, ein neuartiges Spasmolytikum und Analgetikum (chemisches und pharmakologisches), Deutsch. med. Wchnschr., 1939, lxv, 967. CrossrefGoogle Scholar2. SCHAUMANN O: Über eine neue Klasse von Verbindungen mit spasmolytischer und zentral analgetischer Wirksamkeit unter besonderer Berücksichtigung des 1-Methyl-4-phenyl-piperidin-4-carbonsäure-äthylesters (Dolantin), Arch. f. exper. Path. u. Pharmakol., 1940, cxcvi, 2. Heft, 109. Google Scholar3. GULLANDROBINSONGOODMANGILMAN JMRLA: The pharmacological basis of therapeutics, 1941, p. 187. Google Scholar4. DUGUIDHEATHCOTE AMRS: Pharmacological action of ethyl methylphenylpiperidinecarboxylate, Quart. Jr. Pharmacol., 1940, xiii, 318. Google Scholar5. KIESSIGORZECHOWSKY HJG: Ueber die analgetische Wirkung des 'Dolantins,' Schermz Narkose u. Anesthesia, 1940, xiii, 49. Google Scholar6. IZARLENZI GS: Studi sulla Dolantin, Rassegua internaz. di. clin. e. terap, 1941, xxii, 215. Google Scholar7. GRUBERHARTGRUBER CMERCM: Pharmacology and toxicology of ethyl ester of 1-methyl-4-phenyl-piperidine-4-carboxylic acid (demerol), Jr. Pharmacol. and Exper. Therap., 1941, lxxiii, 319. Google Scholar8. YONKMANNOTHHECHT FFPHH: Some pharmacologic features of demerol, Proc. Cent. Soc. Clin. Res., 1942, xv, 89. Google Scholar9. BARLOW OW: Studies on demerol (personal communication), 1942. Google Scholar10. CLIMENKO DR: Demerol: A pharmacologically active substance with atropine-like and morphine-like properties, Feder. Proc., 1942, i, 15. Google Scholar11. NOTHHECHTYONKMAN PHHHFF: Demerol: a new synthetic analgetic, spasmolytic and sedative agent. II. Clinical studies, ANN. INT. MED., 1944, xxi, 17-34. Google Scholar12. YONKMANHIEBERTSINGH FFJMH: Morphine and intestinal activity, New England Jr. Med., 1936, ccxiv, 507. CrossrefGoogle Scholar13. YONKMAN FF: Colon activation by intravenous hypertonic sodium chloride injection in unanesthetized, trained dogs, Proc. Soc. Exper. Biol. and Med., 1932, xxix, 1207. CrossrefGoogle Scholar14. HARDYWOLFFGOODELL JDHGH: Studies on pain. New method for measuring pain threshold: observations on spatial summation of pain, Jr. Clin. Invest., 1940, xix, 649. CrossrefGoogle Scholar15. MCGOWANBUTSCHWALTERS JMWLW: Pressure in the common bile duct of man, Jr. Am. Med. Assoc., 1936, cvi, 2227. CrossrefGoogle Scholar16. OCKERBLADCARLSONSIMON NFHEJF: Effect of morphine upon human ureter, Jr. Urol., 1935, xxxiii, 356. CrossrefGoogle Scholar17. BATTERMAN RC: The clinical effectiveness and safety of a new synthetic analgesic drug, Demerol, Arch. Int. Med., 1943, lxxi, 345. CrossrefGoogle Scholar18. BATTERMAN RC: Demerol—A new synthetic analgesic, Jr. Am. Med. Assoc., 1943, cxxii, 222. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Detroit, Michigan*Received for publication July 10, 1943.From the departments of Pharmacology and Therapeutics and of Medicine of Wayne University and from the department of Medicine of Receiving Hospital and the Medical Division of the William J. Seymour Hospital. This interdepartmental study of demerol hydrochloride received the support of Dr. J. Mark Hiebert of the Alba Pharmaceutical Division of the Winthrop Chemical Company, Inc. The project was aided by the A. Mendelson Memorial Fund of Detroit. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMeperidine: A Critical ReviewAsthma bronchialeCaution against the use of meperidine hydrochloride (isonipecaine, demerol) in patients with heart disease, particularly auricular flutterTHE USE OF DEMEROL IN PATIENTS WITH BRONCHIAL ASTHMA*J. A. HERSCHFUS, M.D., A. SALOMON, M.D., M. S. SEGAL, M.D., F.A.C.P.ANAESTHESIA FOR BRONCHOSCOPY*THE ACTION OF MORPHINE, PETHIDINE, AND AMIDONE UPON THE INTESTINAL MOTILITY OF CONSCIOUS DOGSMultiple-Balloon Kymographic Recording of the Comparative Action of Demerol, Morphine and Placebos on the Motility of the Upper Small Intestine in ManDelayed Gastric Empyting Time in Labor**Presented at a meeting of the Philadelphia Obstetrical Society, May 5, 1949.Some effects of meperidine (Demerol) on gastro-enteric, extra-hepatic biliary, and cardiovascular activity*, ††Supported in part by a grant from Winthrop-Stearns. Inc.PHARMACOLOGY OF DEMEROL AND ITS ANALOGUESThe role of delayed gastric emptying time in the etiology of aspiration pneumoniaStudies on the local anesthetic properties of isonipecaineRecent Advances in Pharmacology 1 July 1944Volume 21, Issue 1Page: 7-16KeywordsCodeineDrug therapyHospital medicineMorphinePharmacologySedativesVenoms ePublished: 1 December 2008 Issue Published: 1 July 1944 PDF downloadLoading ...