tbuckley/cabot-search huggingface dataset:
Interstitial lung disease in a child heterozygous for the 1549C→GAA (121ins2) mutation of surfactant protein B: Figure 1–
Authors: F.P. Rossi, T. Salerno, D. Peca, O. Danhaive, R. Boldrini, L. Menchini, R. Cutrera
Journal: European Respiratory Journal (2011)

the development of malakoplakia are an unusual strain of bacteria, an altered immune response, an altered histiocytic response or intrinsically abnormal macrophages [5].The most common site of infection in females is the urinary tract and it is associated with infection with Gram-negative organisms, mainly Escherichia coli and Klebsiella sp.The extragenitourinary sites that are involved are the skin and the pulmonary, renal and gastrointestinal tract.Other microorganisms associated with malakoplakia are Rhodococci equi, Mycobacteria sp., Pasteurella multocida, Proteus mirabilis, Pseudomonas aeruginosa, Yersinia sp., Staphylococcus aurues and fungal infection [6][7][8][9].Thus, in cases such as ours where no positive microbiology is obtained, antibiotics covering Gram-positive and -negative organisms should perhaps be used for at least 2 weeks.So far, less than 40 cases of pulmonary malakoplakia have been reported and there is therefore little evidence for definite treatment.Pulmonary malakoplakia can present as a lung mass with radiological findings consistent with malignancy or infection.Signs and symptoms are nonspecific and clinical presentation depends on the organ system involved.Conservative treatment with antibiotics results in the regression of the disease in most cases.In this case, the patient was immunocompetent and no positive microbiology was obtained on bronchoalveolar lavage.Diagnosis was confirmed on core biopsy under CT guidance of the lesion extending from the left lower lobe of the lung, through the left hemidiaphragm to the upper pole of the left kidney.Although the PET scan was positive, a biopsy was performed to establish and confirm diagnosis.In this instance, this was of immense importance as the diagnosis changed from a radiological diagnosis of stage IV lung cancer to a potentially curable inflammatory condition.PET results must be interpreted within the clinical context and, where possible, a tissue diagnosis is desirable to confirm diagnosis.Our patient was empirically treated with antibiotics for 4 weeks and a subsequent CT scan showed a decrease in the size of the lesion.In 1996, OZKU ¨RKc ¸U ¨GIL et al.[10] reported a case of renal malakoplakia with pulmonary involvement.Diagnosis of malakoplakia was confirmed at nephrectomy.Treatment with antibiotics led to regression of the lung lesion.At present, no case of malakoplakia extending from the kidney to the lung with possible involvement of the spleen has been reported.
The Occurrence of Cytomegalovirus Infections in Childhood Leukemia
Authors: Ayten Cangir
Journal: JAMA (1966)

Cytomegalic inclusion disease (CMID) presented the following clinical findings in three children with acute leukemia: persistent high temperature, cough, vomiting, diarrhea, hepatosplenomegaly, rales, and terminal icterus. Pancytopenia was present in all including two children in leukemic remission. Roentgenographic evidence of pneumonia did not appear until the third week after the onset of symptoms. Abnormalities in liver function tests were late findings. Intranuclear inclusions were seen in urine sediments of two patients. In neither of these patients were intranuclear inclusions demonstrable in the sputa. Virus culture from urine was done in one of these patients and cytopathogenic changes characteristic of cytomegalovirus (CMV) were demonstrated. CMID was the cause of death in these three children, all of whom had received chemotherapy with agents known to have immunosuppressive properties.
MGUARD MESH-COVERED STENT FOR TREATMENT OF ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION WITH HIGH THROMBUS BURDEN DESPITE MECHANICAL ASPIRATION
Authors: Rafael Romaguera, Guillermo S&aacute;nchez-Elvira, Joan Antoni Gomez-Hospital, Josep Gomez-Lara, Jose Luis Ferreiro, Gerard Roura, Silvia Homs, Francesc Jara, Luis M. Teruel, Angel Cequier
Journal: Journal of the American College of Cardiology (2012)
Postheparin Lipoprotein Lipases
Authors: C.J. Glueck
Journal: New England Journal of Medicine (1975)

A heterogeneous group of enzymes, including hepatic and extrahepatic lipases, monoglyceride hydrolase, and phospholipase, are released into plasma after heparin injection, and may function in clearance of plasma triglycerides, which are transported by chylomicrons and very-low-density lipoproteins.1 Hydrolysis of plasma triglycerides by lipoprotein lipase probably occurs in capillary endothelial cells and in the subendothelial spaces of adipose tissue.2 The relations of adipose-tissue lipoprotein lipase and hypertriglyceridemia in human beings have been assessed, with observation of a negative correlation between lipase activity and serum triglyceride levels.3 In postheparin plasma total lipolytic activity is composed of at least two triglyceride lipases, one . . .
Potential role for peroxisome proliferator activated receptor (PPAR) in preventing colon cancer
Authors: L Jackson
Journal: Gut (2003)

Peroxisome proliferator activated receptors (PPARs) are nuclear hormone receptors involved in genetic control of many cellular processes. PPAR and PPAR have been implicated in colonic malignancy. Here we provide three lines of evidence suggesting an inhibitory role for PPAR in colorectal cancer development.Levels of PPAR mRNA and protein in human colorectal cancers were compared with matched non-malignant mucosa using RNAse protection and western blotting. APC(Min)/+ mice were randomised to receive the PPAR activator methylclofenapate 25 mg/kg or vehicle for up to 16 weeks, and small and large intestinal polyps were quantified by image analysis. The effect of methylclofenapate on serum stimulated mitogenesis (thymidine incorporation), linear cell growth, and annexin V and propidium iodide staining were assessed in human colonic epithelial cells.PPAR (mRNA and protein) expression levels were significantly depressed in colorectal cancer compared with matched non-malignant tissue. Methylclofenapate reduced polyp area in the small intestine from 18.7 mm(2) (median (interquartile range 11.1, 26.8)) to 9.90 (4.88, 13.21) mm(2) (p=0.003) and in the colon from 9.15 (6.31, 10.5) mm(2) to 3.71 (2.71, 5.99) mm(2) (p=0.009). Methylclofenapate significantly reduced thymidine incorporation and linear cell growth with no effect on annexin V or propidium iodide staining.PPAR may inhibit colorectal tumour progression, possibly via inhibition of proliferation, and may be an important therapeutic target.
AB0052 Tnfa influences rasgrp1 and rasgrp3 expression levels in pbmc, b and t cells.
Authors: M.-L. Golinski, M. Hiron, C. Guillou, C. Derambure, O. Boyer, X. Le Loët, O. Vittecoq, T. Lequerré
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid arthritis (RA) is the most common inflammatory arthritis. B and T lymphocytes play a central role in the pathophysiology of RA. RasGRP is a member of the CDC25 family of Ras guanyl nucleotide exchange factors. RasGRP1 is expressed in T and B cells whereas RasGRP3 is only expressed in B cells. In previous studies, we have shown that RasGRP3 expression level significantly decreased in Peripheral blood mononuclear cells (PBMC) from RA patients responders to adalimumab after 3 months, leading to the question of TNFα involvement in pathways including RasGRP1 and RasGRP3. <h3>Objectives</h3> To study TNFα effects on RasGRP1 and RasGRP3 expression levels in vitro. <h3>Methods</h3> We measured by qRT-PCR, RasGRP1 and RasGRP3 expression levels, i) in PBMC from 3 healthy controls (HC), ii) in negative selected B and T cells from PBMC isolated from 3 buffy coat. In each condition, cells were cultured with or without BCR or TCR stimulation for 4 days and TNFα was added for 24 or 48 hours. Immunofluorescence staining was performed to check the cell purity and B and T cells stimulation by flow cytometry. To test the functionals effects of RasGRP1 and RasGRP3 overexpression in T and B cells respectively, IL-2 production was measured by ELISA in T-cells, and Elk-1 expression level was measured by qRT-PCR in B cells before and after TNFα stimulation. In addition, TNFα effects on cell proliferation were evaluated by [3H] thymidine incorporation by the B and T cells. <h3>Results</h3> In B cells, TNFα induced an increase of RasGRP1 (p&lt;0.001) and RasGRP3 (p&lt;0.001) expression levels in absence of BCR stimulation. In the same way, in T cells, TNFα induced an increase of RasGRP1 (p&lt;0.001) and RasGRP3 (p&lt;0.001) expression levels in absence of TCR stimulation. Furthermore, TNFα induced a significantly increase of IL-2 production (p&lt;0.05) in unstimulated T cells and of Elk-1 expression level (p&lt;0.01) in unstimulated B cells. However, TNFα have no effects on B and T cells proliferation. <h3>Conclusions</h3> This study suggests the RasGRP1 and RasGRP3 regulation by TNFα, independently of B and T cells stimulation. The increasing of RasGRP3 and RasGRP1 in B and T cells specifically via TNFα binding on its receptors could promote the activation and proliferation of B and T cells by an independent antigen pathway. This second pathway could explain the maintenance of B and T cells activation. <h3>Disclosure of Interest</h3> None Declared
GW25-e4230 Post-ischemic myocardial insulin resistance induced by TNF-α overproduction precipitates the development of heart failure after myocardial infarction
Authors: Fu Feng, Jia Li, Jie Xu, Yuan Zhang, Chao Gao, Jun Li, Haifeng Zhang, Feng Gao
Journal: Journal of the American College of Cardiology (2014)
Ampac Campaign Contributions to Congress — A Correction
Authors: Joshua Sharfstein, Steven Sharfstein
Journal: New England Journal of Medicine (1995)

To the Editor: We have become aware of two minor errors in the data we used in our article on contributions from the American Medical Political Action Committee (AMPAC) to members of Congress (Jan. 6, 1994, issue).1 The first error occurred when we counted a contribution to a Republican named Jones as a contribution to his Democratic opponent, also named Jones. The second was an error in which we counted a small contribution to a representative when no such contribution was made. In our Table 1, 91.1 percent of House members supporting tobacco-export promotion received AMPAC funds in 1989 and . . .
754. Different Regulation of Myocardial Atrial and Ventricular Calcium Pump Activity (Ca-ATP-ase) during Cardiac Arrest
Authors: Ernoe Remsey-Semmelweis, John G. Kral, Richard B. Wait, M.A.Q. Siddiqui
Journal: Molecular Therapy (2005)

Ca++-ATP-ase activity is a sensitive marker of myocardial metabolic integrity and ischemia. We hypothetized that changes occur in atria (A) and ventricle (V) Ca++ATP-ase mRNA expression of this gene during cardiac arrest protected by continuous warm blood cardioplegia (CWBCP).
Rheumatic Heart Disease in Scarlet-Fever Patients Treated with Penicillin
Authors: Louis Weinstein, Norman H. Boyer, Martin Goldfield
Journal: New England Journal of Medicine (1955)

IN 1948 Massell, Dow and Jones1 reported that the administration of penicillin to rheumatic subjects with established streptococcal infections prevented the recurrence of rheumatic fever. Two years later, Denny and his co-workers2 recorded a marked reduction in the frequency of this disease after penicillin therapy of streptococcal pharyngitis in normal adults. In this study, and in a subsequent one carried out by Wannamaker et al.,3 978 men with this type of sore throat were given penicillin whereas 996 control patients, selected only on the basis of the Air Force serial numbers, received no specific treatment. On the basis of the . . .
Statistical design and evaluation of a propranolol HCl gastric floating tablet
Authors: Meka Venkata Srikanth, Nali Sreenivasa Rao, Songa Ambedkar Sunil, Battu Janaki Ram, Venkata Ramana Murthy Kolapalli
Journal: Acta Pharmaceutica Sinica B (2012)

The purpose of this research was to apply statistical design for the preparation of a gastric floating tablet (GFT) of propranolol HCl and to investigate the effect of formulation variables on drug release and the buoyancy properties of the delivery system. The contents of polyethylene oxide (PEO) WSR coagulant and sodium bicarbonate were used as independent variables in central composite design of the best formulation. Main effects and interaction terms of the formulation variables were evaluated quantitatively using a mathematical model approach showing that both independent variables have significant effects on floating lag time, % drug release at 1 h (D1 h) and time required to release 90% of the drug (t90). The desired function was used to optimize the response variables, each with a different target, and the observed responses were in good agreement with the experimental values. FTIR and DSC studies of the statistically optimized formulation revealed there was no chemical interaction between drug and polymer. The statistically optimized formulation released drug according to first order kinetics with a non-Fickian diffusion mechanism. Evaluation of the optimized formulation in vivo in human volunteers showed that the GFT was buoyant in gastric fluid and that its gastric residence time was enhanced in the fed but not the fasted state.
Basic Medical Education
Authors: Norman B. Roberg
Journal: JAMA (1973)

This small, excellent book covers all aspects of medical education—clinical and preclinical years; the scope, content, and goals of curricula; acquisition of information, skills, and attitudes; the diverse natures of students and teachers; and methods of teaching and assessment. It offers a clear distillate of experience, seasoned by judgment. Sinclair assumes that the quality of education depends on the quality of teachers and students, and that the curriculum, a framework, is of secondary importance. He criticizes curricular reforms and momentous decisions based on "dubious assumptions, scrappy data and mere hunch." Although teaching is an art that can be learned, the number of good teachers remains limited, and curricular reforms should be judged by their economy of the teachers' energies. The lecture remains, thus, the best method for good teachers to reach the most students. The value of integrated or correlated curricula, or interdisciplinary conferences, seminars, tutorials and small-group teaching should
Meningitis and pneumonia due to novel multiply resistant pneumococci.
Authors: K P Klugman, H J Koornhof, V Kuhnle, S D Miller, P J Ginsburg, A C Mauff
Journal: BMJ (1986)

circulating immune complexes seems the most likely explanation.We believe that this is the first case of pyoderma gangrenosum to occur after elective surgery.It highlights the importance of early clinical diagnosis in a condition that is usually highly amenable to treatment.1 Powell FC, Schroeter AL, Su WPD, Perry HO.Pyoderma gangrenosum: a review of 86 patients.
Isolated acral Darier's disease with haemorrhagic lesions in a kindred
Authors: R. Regazzini, G. Zambruno, C. Defilippi, R. Rosso, A. Donadini
Journal: British Journal of Dermatology (1996)

Journal Article Isolated acral Darier's disease with haemorrhagic lesions in a kindred Get access R. Regazzini, R. Regazzini Department of Dermatology, IRCCS Policlinico S. Matteo, Pavia Search for other works by this author on: Oxford Academic Google Scholar G. Zambruno, G. Zambruno Laboratory of Skin Molecular and Cellular Biology, IRCCS Istituto Dermopatico dell'Immacolata, Roma Search for other works by this author on: Oxford Academic Google Scholar C. Defilippi, C. Defilippi Department of Dermatology, IRCCS Policlinico S. Matteo, Pavia Search for other works by this author on: Oxford Academic Google Scholar R. Rosso, R. Rosso Department of Pathology, IRCCS Policlinico San Matteo, Pavia Search for other works by this author on: Oxford Academic Google Scholar A. Donadini A. Donadini Department of Dermatology, IRCCS Policlinico S. Matteo, Pavia Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 135, Issue 3, 1 September 1996, Pages 495–496, https://doi.org/10.1111/j.1365-2133.1996.tb01531.x Published: 01 September 1996
Techniques for Measuring Body Composition: Proceedings of a Conference, Quartermaster Research and Engineering Center, Natick, Mass., January 22-23, 1959
Authors: M. I. Grossman
Journal: JAMA (1962)

The proceedings of a conference held at the Quartermaster Research and Engineering Center, Natick, Mass., January 22-23, 1959 compresses into 300 pages a comprehensive and critical survey of all the methods that have been used to measure the composition of the human body. There are sections of somatometric, volumetric, and biochemical approaches to the problem of body composition. The unique value of this book is that it brings together the findings and opinions of the leaders in the various disciplines whose interests converge in the subject of body composition. A section on interrelations and comparisons is valuable in showing how the various approaches differ and how they may be put to practical use in measuring adiposity, muscularity, and in applying the concept of lean body mass as a metabolic reference standard. The last section is an epilogue by Josef Brožek in which the literature from the time of the conference
Infectious Mononucleosis and Chloroquine Phosphate
Authors: Willard Dalrymple
Journal: JAMA (1961)

<h3>To the Editor:—</h3> Following the publication inThe Journalof Gothberg's report on the rapid response of 4 cases of infectious mononucleosis to chloroquine phosphate (<b>173</b>:53-57 [May 7] 1960), the late Dr. Andrew W. Contratto and I treated 6 successive febrile patients ill with infectious mononucleosis by means of chloroquine in comparable doses. Only 1 of the 6 became afebrile within 48 hours, and his pharyngitis took a longer period to subside; all of Gothberg's cases had become afebrile in 36 hours and the associated pharyngitis in one had also subsided. We had planned these cases as a small pilot study, to be followed by a double-blind evaluation. These negative results have not justified the double-blind evaluation, in our minds, for it seems unlikely that the response of Gothberg's patients was anything more than coincidental. The other possibility is that, since infectious mononucleosis is a syndrome rather than a
Metabolism and the leukemic stem cell
Authors: Omar Abdel-Wahab, Ross L. Levine
Journal: The Journal of Experimental Medicine (2010)

Acute leukemias are clonal disorders of hematopoiesis wherein a leukemic stem cell (LSC) acquires mutations that confer the capacity for unlimited self-renewal, impaired hematopoietic differentiation, and enhanced proliferation to the leukemic clone. Many recent advances in understanding the biology of leukemia have come from studies defining specific genetic and epigenetic abnormalities in leukemic cells. Three recent articles, however, further our understanding of leukemia biology by elucidating specific abnormalities in metabolic pathways in leukemic hematopoiesis. These studies potentially converge on the concept that modulation of reactive oxygen species (ROS) abundance may influence the pathogenesis and treatment of acute myeloid leukemia (AML).
The Epidemiology of Prescriptions Abandoned at the Pharmacy
Authors: Michael Van Ornum
Journal: Annals of Internal Medicine (2011)

Letters17 May 2011The Epidemiology of Prescriptions Abandoned at the PharmacyMichael Van Ornum, RPh, RN, BCPSMichael Van Ornum, RPh, RN, BCPSFrom Healthcare Information and Management Systems Society, Chicago, IL 60611-3270.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-154-10-201105170-00018 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read Shrank and colleagues' article (1) with great interest. A comparison of electronically prescribed medications with paper-prescribed medications generated from a medical office is the Holy Grail of electronic-prescribing research. The problem in realizing this comparison is the extreme difficulty of capturing all non–electronically prescribed medications. Providers have not only paper but also fax machines, telephones, and surrogates to deliver orders to the pharmacy.Shrank and colleagues imply that a solution to this problem of assessing non–electronically prescribed medications exists without disclosing any supporting evidence when they state, “Prescriptions delivered electronically to the pharmacy were almost ...Reference1. Shrank WH, Choudhry NK, Fischer MA, Avorn J, Powell M, Schneeweiss S, et al. The epidemiology of prescriptions abandoned at the pharmacy. Ann Intern Med. 2010;153:633-40. [PMID: 21079218] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Healthcare Information and Management Systems Society, Chicago, IL 60611-3270.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Epidemiology of Prescriptions Abandoned at the Pharmacy William H. Shrank , Niteesh K. Choudhry , Michael A. Fischer , Jerry Avorn , Mark Powell , Sebastian Schneeweiss , Joshua N. Liberman , Timothy Dollear , Troyen A. Brennan , and M. Alan Brookhart The Epidemiology of Prescriptions Abandoned at the Pharmacy Jeanette L. Altavela The Epidemiology of Prescriptions Abandoned at the Pharmacy William H. Shrank , Niteesh K. Choudhry , and M. Alan Brookhart Metrics 17 May 2011Volume 154, Issue 10Page: 705-706KeywordsConflicts of interestEpidemiology ePublished: 17 May 2011 Issue Published: 17 May 2011 CopyrightCopyright © 2011 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Physicians and Patient Spirituality: Professional Boundaries, Competency, and Ethics
Authors: Stephen G. Post, Christina M. Puchalski, David B. Larson
Journal: Annals of Internal Medicine (2000)

Clinical studies are beginning to clarify how spirituality and religion can contribute to the coping strategies of many patients with severe, chronic, and terminal conditions. The ethical aspects of physician attention to the spiritual and religious dimensions of patients' experiences of illness require review and discussion. Should the physician discuss spiritual issues with his or her patients? What are the boundaries between the physician and patient regarding these issues? What are the professional boundaries between the physician and the chaplain? This article examines the physician–patient relationship and medical ethics at a time when researchers are beginning to appreciate the spiritual aspects of coping with illness.
STIFF LEFT ATRIAL SYNDROME FOLLOWING CATHETER ABLATION FOR ATRIAL FIBRILLATION: CLINICAL CHARACTERIZATION, PREVALENCE AND PREDICTORS
Authors: Doug N. Gibson, Luigi Di Biase, Prasant Mohanty, Rong Bai, Javier Sanchez, David Burkhardt, Thomas Heywood, Allen D. Johnson, David S. Rubenson, Rodney Horton, Joseph G. Gallinghouse, Shane M. Bailey, Sanghamitra Mohanty, Salwa Beheiry, Guy P. Curtis, Jigar D. Patel, David N. Cohen, Mark Y. Lee, Michael R. Smith, Devi Gopinath, William R. Lewis, Andrea Natale
Journal: Journal of the American College of Cardiology (2011)
The role of nonselective beta-blockers in the prevention of gastric variceal rebleeding
Authors: S. Evrard, O. Le Moine, J. Devière
Journal: Endoscopy (2008)

We read with great interest the study of Lo et al. [1] comparing the transjugular intrahepatic portosystemic shunt with cyanoacrylate injection in the prevention of gastric variceal rebleeding. No mention is made in the article about medical treatment using beta-blockers, which remains part of the secondary prophylaxis of variceal bleeding. This certainly deserves further study before any statement that the transjugular intrahepatic portosystemic shunt might be the treatment of choice for prevention of gastric variceal rebleeding. We agree that controlled studies concerning the management of gastric variceal rebleeding are very poor, but currently beta-blockers cannot be ruled out.