tbuckley/cabot-search huggingface dataset:
Night: A Fragment
Authors: Randall Mann
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 11313: Expression of Mitochondrial Fusion Proteins is Increased Within Hibernating Myocardium Following CABG
Authors: Eric K Long, Christopher T Holley, Cayla M Duffy, Tammy A Butterick, Herbert B Ward, Edward O McFalls, Rosemary F Kelly
Journal: Circulation (2014)

Background: We have shown that expression of mitochondrial electron transport proteins is reduced 4 weeks following bypass surgery (CABG). In this study, we tested whether the expression of mitochondrial fusion proteins (Opa1) and mitofusins (Mfn 1&2), as an indicator of early recovery of the mitochondrial proteome, is increased post-CABG. Methods: Nine pigs underwent placement of a constrictor on the LAD artery and had reduced function at 12 weeks. Four pigs underwent off-pump revascularization with a left internal mammary artery graft beyond the LAD stenosis (+CABG). Patent grafts were confirmed by CTA post-CABG. Five hibernating pigs without CABG served as comparisons (-CABG). Data were compared to 5 SHAM-operated controls (Con) without LAD constrictor. Prior to sacrifice, blood flows by μspheres were determined during dobutamine (40 μg/kg/min). Post-sacrifice, the content of mitochondrial fusion proteins and nuclear-bound PGC1α was determined by westerns. Results: In the +CABG Group, blood flows durin...
Screening for Coronary Calcification—Reply
Authors: Hidekatsu Yanai, Mie Morimoto
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 833: MicroRNA-206 Controls Cardiac Myosin Heavy Chain Gene Expression By Targeting RXR-{alpha}
Authors: Hitoo Nishi, Koh Ono, Yoshitaka Iwanaga, Takahiro Horie, Minako Kinoshita, Kazuya Nagao, Rieko Mori, Koji Hasegawa, Toru Kita
Journal: Circulation (2007)
RATIONAL TREATMENT OF THE ANEMIC PATIENT
Authors: William P. Murphy
Journal: Annals of Internal Medicine (1934)

Article1 February 1934RATIONAL TREATMENT OF THE ANEMIC PATIENTWILLIAM P. MURPHY, M.D.WILLIAM P. MURPHY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-8-939 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAdequate treatment for anemia is that which produces and maintains the best state of health possible for the individual patient. The best treatment is that which is adequate and is available at a minimum of inconvenience and expense. Rational treatment is the best treatment expedient for the patient whose particular problem is under consideration.The treatment which may be considered rational for improving the condition of the blood may not be so for its maintenance in a satisfactory condition, or for maintenance of the patient in a proper state of health thereafter. An example of this situation is the following:...Bibliography1. MURPHY WP: Parenteral use of liver extract in pernicious anemia, Jr. Am. Med. Assoc., 1932, xcviii, 1051-1060. CrossrefGoogle Scholar2. MURPHY WP: Reticulocyte, erythrocyte and hemoglobin production in anemia and the effect upon them of certain types of therapy, Arch. Int. Med., 1933, lii, 829-838. CrossrefGoogle Scholar3. MINOT GR: The importance of treatment of pernicious anemia on a quantitative basis, Jr. Am. Med. Assoc., 1932, xcix, 1906-1908. CrossrefGoogle Scholar4. MURPHYHOWARD WPIM: Dietary considerations in the treatment of anemia, Trained Nurse and Hosp. Rev., 1933, xc, 55. Google Scholar5. MURPHY WP: Treatment of secondary anemia, with special reference to use of liver extract intramuscularly, Arch. Int. Med., 1933, li, 656-678. CrossrefGoogle Scholar6. Report of committee on costs of medical care; reviewed in The Diplomate, 1933, v, 13. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Read before the American Therapeutic Society, June 10, 1933, at Milwaukee, Wisconsin. Received for publication August 23, 1933.From the Medical Clinic of the Peter Bent Brigham Hospital, Boston. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Erkrankungen des erythrocytären SystemsFluorescenzphänomen und Porphyringehalt der ErythrocytenErkennung und Behandlung der AnämienFunikuläre Spinalerkrankungen 1 February 1934Volume 7, Issue 8Page: 939-947KeywordsAnemiaBloodHospitals ePublished: 1 December 2008 Issue Published: 1 February 1934 PDF downloadLoading ...
Abstract 2723: Breast cancer type 1 susceptibility protein mimetics induce specific estrogen receptor confirmations and inhibit MCF7 breast cancer cell proliferation
Authors: Bethany Kristen Asare, Christ Ange Katche, Rajendram V. Rajnarayanan
Journal: Cancer Research (2014)

Abstract The human Estrogen Receptor (hER) is present in 70% of breast cancers, and dysregulation of hER signaling can lead to aberrant cell growth and proliferation. Known anti-estrogens used in treatments of breast cancer today, tamoxifen and raloxifene cause hER to undergo conformational changes and inhibit normal hER signaling by directly binding to the ligand binding pocket. However, often breast cancer cells become resistant to tamoxifen, and prolonged tamoxifen treatment can lead to endometrial cancers. Breast Cancer Type 1 Susceptibility protein (BRCA1) is a well characterized inhibitor of breast cancer cell growth. BRCA1 plays an important role in maintaining genomic stability through various DNA repair mechanisms. It is mutated in approximately 50% of breast cancer cases that are associated with heredity. While the majority of breast cancer cases are “sporadic” or unassociated with heredity, BRCA1 is expressed 30 to 40 % less in sporadic breast cancers. BRCA1 has also been shown to associate directly with hER, and inhibit transactivation of hER. This association and inhibition of hER transcriptional activity is reversed by cyclin D1. This, in conjunction with studies that have shown that cyclin D1 gene and protein levels are amplified and overexpressed respectively in breast cancers suggest that the normal regulation of hER by BRCA1 and cyclin D1 may be shifted in breast cancers to primarily regulation (activation) by cyclin D1 and other coactivators. A decrease in BRCA1 is associated with acquired tamoxifen resistance, suggesting that BRCA1 may play a critical role in maintaining breast cancer cells sensitivity to tamoxifen. The hER binding region of BRCA1 contains the known corepressor binding motif LXXIIXXXL (amino acids 78-95). Here we present a study of several small molecules identified based on pharmacophoric features of previously found conformation sensing BRCA1 peptides. BRCA1 mimetics induce unique ER conformations and inhibit breast cancer cell growth (MCF7). Further development of these compounds could lead to viable alternative breast cancer treatments as well as supplemental treatments in the anti-estrogen resistant cases. Acknowledgements: This research was supported via funds from the New York State, National Institutes of Health (5P20MD002725), through the NCMHD -RIMI program (RVR) and NSF LSAMP Bridge to Doctorate grant (BKA). Citation Format: Bethany Kristen Asare, Christ Ange Katche, Rajendram V. Rajnarayanan. Breast cancer type 1 susceptibility protein mimetics induce specific estrogen receptor confirmations and inhibit MCF7 breast cancer cell proliferation. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2723. doi:10.1158/1538-7445.AM2014-2723
Abstract P240: Increased Aerobic Fitness is associated with Cardiometabolic Risk Reduction in a High Cardiovascular Disease Risk Occupational Cohort Independent of Significant Weight Loss
Authors: Ehimen C Aneni, Ebenezer Oni, Lara Roberson, Maribeth Rouseff, Henry Guzman, Thinh H Tran, Sankalp Das, Doris Brown, Joann Santiago-Charles, Teresa C Ochoa, Joseph Mora, Cynthia Gilliam, Virginia Lehn, Josette Bou-Khalil, Beatriz Castillo, Emir Veledar, Theodore Feldman, Arthur S Agatston, Janisse Post, Khurram Nasir
Journal: Circulation (2014)

Background: Studies have demonstrated that improving physical fitness is associated with weight loss and improvement in cardio-metabolic risk profile. However, the effect of improvement in aerobic fitness on metabolic risk in the absence of significant weight loss in a high risk working population is poorly understood. We examined efficacy of both weight reduction and increased aerobic fitness on metabolic syndrome in an ongoing multicomponent lifestyle intervention improvement program (My Unlimited Potential (myUP)), among employees of Baptist Health South Florida (BHSF). Methods: The study population included 158 participants who had at least 2 metabolic risk factors at baseline. An advanced nurse practitioner, registered dietician, exercise physiologist, certified diabetic educator, and registered nurse met with participants to provide one-on-one counseling and fitness training. During the first 12 weeks the multidisciplinary team rigorously supervised participants. Results: Over the 12 week period, there was a significant increase in METS (median difference 2.7; IQR 1.4 to 3.4 p&lt;0.001). Over the same period the prevalence of metabolic syndrome reduced from 48% to 25% (p &lt;0.001). The increase in METS was greater among those with significant weight loss defined as weight loss at least 5% of baseline body weight (median difference = 1.30, P&lt;0.001). In a fully adjusted logistic regression model, there was markedly significant reduction in the risk of metabolic syndrome at 3 months among those who had shown improvements in fitness alone (OR 0.15, p=0.025) and among those who had both improvements in fitness and significant weight loss (OR 0.14, p=0.030). Conclusion: Improvements in respiratory fitness as can be seen with exercise, even in the absence of significant weight loss, is associated with significant reduction in cardiometabolic risk. In an intensive lifestyle modification interventional program aimed at CVD risk reduction, emphasis should be placed at increasing physical fitness, not only on weight loss.
Olfactory loss
Authors: E Ofo, B O'Reilly, A O'Doherty
Journal: BMJ (2007)

A 65 year old man presents with loss of smell and altered taste, affecting his appetite and food intake. He had an upper respiratory tract infection before the onset of symptoms nine months ago. Initially, normal odours were distorted, followed by a constant foul smell for three months, and then complete loss of smell.
The three paradoxes of private medicine: The golden dustman cometh
Authors: James F R Love
Journal: BMJ (2004)

Incompetent patients may pose a problemEditor-The BMJ ethics committee's revised policy on consent to the publication of patient information is laudable, 1 but an important matter remains overlooked: publishing cases involving incompetent patients.Much can be learnt from these cases; be it highlighting clinical difficulties or drawing attention to neglected moral issues.But the guidelines as written may make it impossible to publish them.Imagine I wished to publish a case involving a traceable adult with learning disability who had requested genetic counselling.Turning to the guidelines, I would be required to obtain her consent before publication.However, obtaining written informed consent from adults with questionable competence could be difficult or exploitative, as they may lack the capacity to understand the implications of consent to publication.Furthermore, the exceptions listed under point 3 do not apply.Merely anonymising her information would be ethically problematic, as could drafting a fictional case "inspired" by the clinical encounter.Until the mental capacity bill becomes law, no one can provide consent on her behalf.How should we balance the value gained from publishing these cases with respecting the interests of the people involved?Rogers and Draper have already addressed this issue in the context of medical ethics research and teaching. 2They argue that using cases with practical obstacles to obtaining consent can often be justified by an appeal to public interest arguments, such as the public's right to know what clinical and ethical dilemmas doctors face.Although more discussion is required, the BMJ ethics committee also needs to develop practical recommendations for the use of case studies where the subject cannot provide full informed consent.
Abstract 19623: Validation of the Pittsburgh Cardiac Arrest Category Illness Severity Score
Authors: Patrick J Coppler, Jonathan Elmer, Luis Caldaron, Alexa Sabedra, Ankur Doshi, Clifton W Callaway, Jonathan C Rittenberger, Cameron Dezfulian
Journal: Circulation (2014)

Introduction:  The purpose of the current study was to both prospectively and retrospectively validate an early post-cardiac arrest illness severity classification ability to predict the likelihood of survival to hospital discharge and good functional outcome.   Hypothesis:  We hypothesized that the Pittsburgh Cardiac Arrest Category (PCAC) would be predictive of post-arrest survival and good functional outcome after adjusting for other determinants of outcome.   Methods:  The PCAC is a 4-level illness severity score that was found to be strongly predictive of patient outcomes in the initial derivation study. We assigned PCAC scores to consecutive in-hospital and out-of-hospital cardiac arrest subjects treated at two tertiary care centers between January 2011 and September 2013. We made these assignments prospectively at Site 1 and retrospectively at Site 2. Our primary outcome of interest was survival to hospital discharge. Secondary outcomes were favorable discharge disposition (home or acute rehabilitation), Cerebral Performance Category (CPC) and modified Rankin Scale (mRS) at hospital discharge. We tested the association of PCAC with each outcome using unadjusted and multivariable logistic regression.   Results:  We included 607 patients admitted with cardiac arrest during the study period (393 at Site 1 and 214 at Site 2). The populations at the two sites differed in age, arrest location, presenting rhythm, use of induced hypothermia and distribution of PCAC. PCAC was associated with survival (unadjusted odds ratio (OR) Site 1: 0.33 (95% confidence interval (CI) 0.27-0.41)) Site 2: 0.32 (95%CI 0.24-0.43)) even after adjustment for other clinical variables (adjusted OR Site 1: 0.32 (95%CI 0.25-0.41)) Site 2: 0.31 (95%CI 0.22-0.44)). PCAC was similarly predictive of secondary outcomes.   Conclusions:  Our results confirm that PCAC is strongly predictive of survival and good functional outcome after cardiac arrest.
435. Adeno-Associated Virus Vectors Are Able To Restore FALDH Deficiency in Cells of Sjoegren-Larsson Syndrome
Authors: Markus Braun-Falco, Stefanie Haug, Hildegard Buning
Journal: Molecular Therapy (2004)

Sjoegren-Larsson syndrome (SLS) is caused by an autosomal recessive defect in the gene coding for fatty aldehyde dehydrogenase (FALDH), an enzyme necessary for the oxidation of long-chain aliphatic aldehydes to fatty acids as part of the fatty alcohol:nicotinamide-adenine dinucleotide (NAD+)-oxidoreductase complex (FAO). The impaired activity of FALDH leads to the clinical triad of generalized ichthyosis, mental retardation, and spastic diplegia or tetraplegia. In order to develop a gene therapy approach for the treatment of SLS, we constructed a recombinant adeno-associated virus vector containing the human cDNA of functional FALDH (rAAV/C-FALDH) and evaluated its capability to restore the enzyme deficiency. First, we transduced a FALDH-deficient Chinese hamster ovary (CHO) mutant resembling the gene defect of SLS. Transduction with rAAV/C-FALDH of FALDH-deficient CHO cells, usually exhibiting less than 10% of normal FALDH activity, resulted in an increase of FALDH activity of up to 80% and more of the activity of unaffected cells. Next, we isolated keratinocytes from SLS-patients and measured their FALDH activity in comparison to keratinocytes of unaffected individuals. The diagnosis of SLS-keratinocytes could be approved by a reduction of FALDH activity below 15% of normal. The SLS-keratinocytes were transduced with rAAV/C-FALDH and rAAV/C-GFP particles as a negative control. FALDH activity of FALDH transduced SLS-keratinocytes was markedly increased in comparison to GFP-transduced SLS-keratinocytes. The level of activity was above 50% of normal and reached the level of heterozygous phenotypically normal carriers. These results indicated that rAAV vectors are able to restore FALDH deficiency in vitro, supporting the concept that gene therapy might be a possible approach for the treatment of SLS.
Work stress and risk of cardiovascular mortality: prospective cohort study of industrial employees
Authors: M. Kivimaki
Journal: BMJ (2002)

<h3>Abstract</h3> <b>Objective:</b> To examine the association between work stress, according to the job strain model and the effort-reward imbalance model, and the risk of death from cardiovascular disease. <b>Design:</b> Prospective cohort study. Baseline examination in 1973 determined cases of cardiovascular disease, behavioural and biological risks, and stressful characteristics of work. Biological risks were measured at 5 year and 10 year follow up. <b>Setting:</b> Staff of a company in the metal industry in Finland. <b>Participants:</b> 812 employees (545 men, 267 women) who were free from cardiovascular diseases at baseline. <b>Main outcome measure:</b> Cardiovascular mortality 1973-2001 from the national mortality register. <b>Results:</b> Mean length of follow up was 25.6 years. After adjustment for age and sex, employees with high job strain, a combination of high demands at work and low job control, had a 2.2-fold (95% confidence interval 1.2 to 4.2) cardiovascular mortality risk compared with their colleagues with low job strain. The corresponding risk ratio for employees with effort-reward imbalance (low salary, lack of social approval, and few career opportunities relative to efforts required at work) was 2.4 (1.3 to 4.4). These ratios remained significant after additional adjustment for occupational group and biological and behavioural risks at baseline. High job strain was associated with increased serum total cholesterol at the 5 year follow up. Effort-reward imbalance predicted increased body mass index at the 10 year follow up. <b>Conclusions:</b> High job strain and effort-reward imbalance seem to increase the risk of cardiovascular mortality. The evidence from industrial employees suggests that attention should be paid to the prevention of work stress.
Emmanuel Andrew Danino Alexander Stuart Douglas Patrick Thomas Doyle Ajay Gautama Graham Douglas Alexander Gordon Frank James Robert Johnson Leslie Ely ("Peter") Lucas Archibald ("Archie") Adam Martin George May Cecil Ashby Mays Robert ("Bob") Richard Weir Mirrey
Authors: C. Danino, C. Forbes, A. Mowat, G R Park, A. Wheatley, F. Murdoch, J. James, J. R Loudon, L. Klenerman, J. Oldroyd, J. R Theobalds, M. May, J. May, C F H Vickers, G. Taylor, R. M L Weir
Journal: BMJ (1999)
Abstract 10269: Urinary 8-hydroxy-2′-deoxyguanosine as a Novel Biomarker of Inflammatory Activity in Patients with Cardiac Sarcoidosis: Insight From Immunohistochemical Technique and 18F-FDG PET/CT
Authors: Seiko Fukuta, Shigeki Kobayashi, Takeo Tanaka, Takehisa Susa, Wakako Murakami, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Tomoko Nao, Jutaro Yamada, Takeshi Ueyama, Takayuki Okamura, Shuji Kawamura, Masafumi Yano, Masunori Matsuzaki
Journal: Circulation (2011)

Background:  Enhanced production of reactive oxygen species, capable of reducing endogenous defense levels and enhancing inflammation, is suggested to play a crucial role in the pathogenesis of cardiac sarcoidosis (SAR). We investigated whether urinary(U) 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, correlates with inflammatory activity in SAR.   Methods and Results:  Immunohistochemical examination of 8-OHdG in the biopsy sample, which was selectively taken from the focus with accumulation of  18 F-FDG by PET/CT, revealed positive staining for 8-OHdG in the nuclei around sarcoidosis granuloma. Serum 8-OHdG (ng/ml) was found to be significantly higher in coronary sinus(CS) than in aorta(A) only in patients with active SAR (active SAR, n=10: 0.70 ±0.11 in CS; 0.35 ± 0.10 in A; non-active SAR, n=8: 0.40±0.13 in CS; 0.35± 0.11 in A). Moreover, we measured U-8-OHdG in 30 control subjects, 30 patients with DCM (LVEF: 27±15%) and 38 patients with SAR (LVEF: 33.8±15%). All patients with SAR underwent  18 F-FDG PET/CT to evaluate the inflammation status for dividing active SAR (n=20) and non-active SAR (n=18). In all patients with active SAR, U-8-OHdG were re-examined in comparison with  18 F-FDG PET/CT to assess response to corticosteroids. U-8-OHdG (ng/ml creatinine) in SAR was higher than that of control subjects (Control vs. all SAR: 8.5±1.9 vs. 17.6±5.3, p 18 F-FDG.   Conclusion:  These findings suggest that U-8-OHdG is a clinically useful biomarker for evaluating inflammatory activity and effectiveness to corticosteroid therapy in SAR patients.