tbuckley/cabot-search huggingface dataset:
Abstract 2799: Noninvasive Quantification of the Atherosclerotic Aorta Component with Flat-Panel Computed Tomography in Rabbits
Authors: Ibrahim Aboshady, Dianna D Cody, MacArthur A Elayda, Deborah Vela, Herbert L DuPont, James T Willerson, L. Maximilian Buja, Gregory W Gladish
Journal: Circulation (2008)

PURPOSE : Flat-panel computed tomography (FpCT) improves spatial resolution and allows better visualization of atherosclerotic lesions than does clinical 64-channel CT scanning (64-CT). In this rabbit study, we demonstrated that noninvasive in vivo FpCT imaging can quantify the different components within atherosclerotic plaque. METHODS: Six anesthetized Watanabe homozygous hyperlipidemic rabbits were scanned with 64-CT (image thickness, 0.625 mm) and FpCT (image thickness, 0.150 mm). Iohexol (2 ml/kg) was administered via an ear vein for each scan. Scanning was performed during full inspiration at 30, 60, and 90 seconds after injection (64-CT) or immediately after injection (FpCT). Small field-of-view images (16-mm) were generated perpendicular to the center line of the aorta at 1-mm intervals; including minimum-thickness images and 2-mm–thick volumetric images using average-, maximum-, and minimum-intensity projection. Vessel wall thickness and area, lipid pools, and calcific deposits were measured on the 2-mm–thick, average-intensity images. The aortas were serially sectioned (~2.0 to 2.5 mm in thickness) in proximal-to-distal fashion for histologic correlation with CT. RESULTS: ANOVA showed a significant correlation - FpCT vs 64-CT, P =0.017; 64-CT vs histology (HS), P =0.012; FpCT vs HS, P &lt;0.001 - in mean wall thickness and vessel wall area as measured by both scanning techniques and by HS (n=192 sections). Plaque with a large necrotic lipid core was observed in 98 FpCT images, 7 64-CT images, and 87 histologic sections. Both FpCT and HS (gold standard) allowed the detection of lipid pools as small as 0.3 mm diameter; 64-CT allowed detection of lipid pools of 1.5 mm diameter or more. In both FpCT and HS images, but not 64-CT images, we identified lesions composed of &lt;5% lipid. Calcific deposits of &lt;1 mm diameter were recognized only in FpCT and HS images. The histopathologic data for plaque eccentricity and circumference, number of lipid pools, and minimal distance of each component from the vascular lumen was better correlated with the FpCT data than the 64-CT data. CONCLUSION: FpCT provides better quantification of plaque components than does 64-CT and is a promising tool for characterizing plaque composition.
Abstract 1841: Left Atrial Volume From 3-dimensional CT Correlates With Atrial Fibrillation Recurrence Following Ablation
Authors: Adam Helms, J. M Mangrum, J. P Mounsey, John P DiMarco, Srijoy Mahapatra, Douglas E Lake, Randall Moorman, John D Ferguson
Journal: Circulation (2007)

Objective: Recurrence of atrial fibrillation (AF) following ablation is common, and further delineation of prognostic markers is needed. We investigated whether LA volume, which can be accurately obtained from 3-dimensional CT, correlates with AF recurrence. Methods: 73 consecutive patients (52 paroxysmal, 21 persistent) undergoing AF ablation were studied. Follow-up was for a minimum of 9 months, and success was determined by 12-lead EKG and lack of symptoms (unless symptoms proven not AF by Holter). LA volume was calculated by summation of axial CT slices. The left atrial appendage was measured separately. Results: Overall procedure success was 66% including 11 (15%) who had repeat ablations and 9 (12%) who were on antiarrhythmics. Pulmonary vein isolation was performed in all, with additional linear ablation in 44 (60%). The mean (95% CI) LA volume for those with recurrent AF was 119 cc (104, 135) versus 98 cc (90, 106) for no recurrence (p=0.01, rank sum). Wide variation in LA volume was noted in both groups (see box plot). For those patients with a volume &gt;135cc (n=11), 9 (82%) had recurrent AF. No correlation existed between recurrence and type of AF or ablation strategy. Patients who had received a linear ablation had a larger mean LA volume than those who had not (111 cc vs. 97 cc, p=0.03, rank sum). LA appendage volume was not associated with recurrence. Conclusion: LA volume variation is large in both those with and without successful AF ablations. Mean LA volume is significantly larger in those with recurrent AF. Patients with LA volumes &gt;135 cc are very likely to experience recurrent AF. More aggressive ablation strategies may be required in patients with large LA volumes.
Abstract 15: Baicalein Protects Cardiomyocytes Against H2O2-induced Mitochondrial Injury
Authors: Hsien-Hao Huang, Jing Li, Willard W Sharp, Chang-Quing Li, Mei Han, Juan Li, Zuo-Hui Shao, Terry L Vanden Hoek
Journal: Circulation (2010)

Introduction: Baicalein is a flavonoid compound extracted from Scutellaria baicalensis root that scavenges reactive oxygen species (ROS) and protects against cardiomyocyte ischemia/reperfusion (I/R...
Abstract 15028: Appropriateness Of Stress Echocardiography In Asymptomatic Patients Post Revascularization
Authors: Serge C Harb, Thomas B Cook, Thomas H Marwick
Journal: Circulation (2011)

Background: Although stress echo (SE) in asymptomatic patients (pts) is thought inappropriate early after revascularization (E-RVS), its appropriateness is indeterminate late after revascularizatio...
Abstract 4221: Cardiac Computed Tomography Angiography in the Setting of Low-Moderate Coronary Artery Disease Risk - Do Results Change Management?
Authors: Robert H Boone, Brett Heilbron, Gordon Andrews, Bruce Forster
Journal: Circulation (2008)

CCTA is sensitive and specific for detecting CAD, but the impact on patient management and outcomes is unknown. We describe our experience with consecutive cases performed at a single CCTA centre. Coronary calcium scoring and contrast-enhanced coronary CT angiograms were performed on 114 patients using a Toshiba 64-slice scanner and standard protocols. Information on demographics, risk factors, symptomatology, prior cardiac investigations and medications was collected by questionnaire and verified by the consulting cardiologist just prior to scan performance. Scan results and management recommendations were recorded. Participants were primarily male (76.1%) with a mean age of 59.8±9.9yrs. CAD risk factor prevalence was: 53.2% hypertensive, 10.6% diabetic, 49% ever smoked, 75.7% with a family history of premature CAD, and mean LDL and HDL were 2.68±0.81 and 1.4±0.43 μmol/L. Baseline medical therapy is listed in Table I . The prevalence of chest discomfort symptoms was: none (55.4%), non-cardiac (4.3%), atypical (15.2%) and typical (25.1%). Prior investigations included MPI (42.1%), and EST (53.5%) with results that were negative (50%, 45.9%) positive (35.4%, 23%) or equivocal (14.6%, 27.9% respectively). A pre-existing diagnosis of CAD was present in 21.9%. Median coronary calcium (Agatston) score was 79 ( range 0→1899). CAD was diagnosed in 71% of patients, and luminal stenosis was &gt;50% in 70% (n=54). Management recommendations included changes to medical therapy (Table I ), further testing (EST (n=3), MPI (n=6), angiography (n=14)), and test cancellation (MPI (n=2)). In no patients did CCTA result in the cancellation of cardiac catheterization. CCTA provided a new diagnosis of CAD in 49% of patients of low-moderate CAD risk, and resulted in a net increase in the number of medications and investigations ordered. The impact on patient morbidity and mortality is the subject of further study. Table I: Medications pre and post CCTA results
Abstract 13765: A New Disease Specific Quality of Life Measure for Children and Adolescents in the United Kingdom
Authors: Jo Wray, Kate Brown, Rodney Franklin, Amy Cassedy, Sophie Guy, Laura Casale, Katelyn Mellion, Mary Burger, Jackie Sage, Charlotte Andersen, Jacqueline Blyth, Bradley S Marino
Journal: Circulation (2010)

Background: Improvements in care for children and adolescents with congenital (CHD) or acquired heart disease (AHD) have lowered mortality rates but increased the number of survivors with morbiditi...
Abstract 17481: Cardiomyocyte, Non-Canonical TGF{beta} Signaling Determines the Pathological Remodeling in Chronic Pressure-Overloaded Heart
Authors: Norimichi Koitabashi, Thomas Danner, Ari L Zaiman, Yigal M Pinto, Djahida Bedja, Janelle Rowell, Marissa Hildebrant, Joseph Mankowski, Dou Zhang, Eiki Takimoto, David A Kass
Journal: Circulation (2010)
Mason Type II Radial Head Fractures Fixed with Herbert Bone Screws
Authors: M S Pearce, S C Gallannaugh
Journal: Journal of the Royal Society of Medicine (1996)

The management of radial head fractures remains controversial. Accurate classification of the fracture (Mason) may necessitate the use of special X-ray views (45° arterior oblique or radio-capitellar). We present the results of 19 cases of Mason type II fractures treated operatively by open reduction and internal fixation with the Herbert bone screw. All patients achieved ‘good-to-excellent’ outcome at follow-up. Our results compare favourably with other forms of treatment for this injury.
Abstract 2124: Modeling Blood Flow in Repaired Coarctation of the Aorta Using Computational Fluid Dynamics
Authors: Laura Olivieri, Diane A DeZelicourt, Christopher Haggerty, Kanishka Ratnayaka, Russell Cross, Ajit Yoganathan
Journal: Circulation (2009)

Coarctation of the aorta accounts for 6% of congenital heart disease. Following adequate surgical repair, late morbidity includes abnormal vasomodulator response, hypertension and exercise-induced ...
Abstract 18218: Vascular Dysfunction as a Primary Cause of Hypertension in Mice with Smooth Muscle Specific Deletion of RGS2
Authors: Robrecht Thoonen, Haihua Zhang, Yuichi Abe, Heather Nickerson, Mark Aronovitz, Robert M Blanton, Pierre Chambon, Michael E Mendelsohn, Richard H Karas
Journal: Circulation (2011)

The etiology of hypertension in most cases is idiopathic. Current dogma states that all forms of hypertension arise from renal abnormalities of sodium handling. We have hypothesized that a primary abnormality of vascular smooth muscle cell (SMC) contraction can cause hypertension. To directly test this hypothesis we created and characterized inducible, SMC-specific RGS2 knockout mice (RGS2-SMC-KO) harboring a SMC-specific deletion of the PKGIα target the GTPase activating protein Regulator of G-protein Signaling 2. In these studies, SMC-specific deletion of RGS2 was induced at 7 weeks of age and Cre-negative mice treated identically as the RGS2-SMC-KO were used as controls. Telemetric blood pressure (BP) studies in ambulatory mice demonstrated that BP was significantly higher in RGS2-SMC-KO vs. control mice (135 ± 5 vs. 122 ± 7 mmHg, respectively. P &lt;0.01), with no change in heart rate. Ex vivo aortic rings of RGS2-SMC-KO mice were hypercontractile in response to phenylephrine (PE) (138 ± 6 vs. 124±4% of pre-existing tone at 6 mM PE, respectively. P &lt;0.05) Hemodynamic studies in anesthetized RGS2-SMC-KO mice revealed increased total systemic vascular resistance (SVR; 3.22x10 4 ± 0.01x10 4 vs. 1.61x10 4 ± 0.55x10 4 , respectively. P &lt;0.001), and significantly higher SBP (106 ± 5 vs. 93 ± 1 mmHg, respectively. P &lt;0.01). Following treatment with the NOS inhibitor L-NAME, BP decreased less in the RGS2-SMC-KO than in the control mice (⋔SBP: 38 ± 7 vs. 47 ± 3 mmHg, P &lt;0.001). We found identical BP responses to changes in dietary sodium intake in the RGS2-SMC-KO mice vs. control, supporting normal renal function in the RGS2-SMC-KO mice. These data support that SMC-specific deletion of RGS2 leads to hypertension, with accompanying loss of RGS2-dependent attenuation of contractile signaling in blood vessels, with increased SVR and hypercontractile arterial function. The hypertension in RGS2-SMC-KO mice together with normal sodium handling supports the hypothesis that high BP can arise from a primary abnormality of vascular smooth muscle cell contractile regulation. Taken together, these data have potentially important implications for the diagnosis and treatment of human vascular diseases and suggest RGS2 as a new therapeutic target for some forms of hypertension.
Abstract 10081: Inhibition of RAGE-Related Pathway Prevents Subarachnoid Hemorrhage (sah)-Associated Neuroinflammation and Neurologic Dysfunction in Rats
Authors: Haoliang Xu, Chanannait Paisansathan, Lizhen Mao, Francesco Vetri, Dale Pelligrino
Journal: Circulation (2011)

Recent study from our laboratory indicated that, in SAH, activation of the receptor for advanced glycation end-products (RAGE)-related pathway contributes to cerebral arteriolar dilating dysfunctio...
BRCA1 and HIF-1α mRNA expression and chemoresistance in non-small-cell lung cancer (NSCLC)
Authors: M. Taron, R. Rosell, J. Souglakos, P. Mendez, E. Felip, A. Barnadas, M. Sanchez, C. Queralt, J. M. Sanchez, J. J. Sanchez
Journal: Journal of Clinical Oncology (2004)

7148 Background: BRCA1 plays a central role in DNA repair, and decreased BRCA1 mRNA expression in the human breast cancer HCC1937 cell line caused cisplatin hypersensitivity, but its role in NSCLC has never been examined. HIF-1α overexpression activates the transcription of genes involved in angiogenesis and chemoresistance. We have examined the potential correlation and predictive value of BRCA1 and HIF-1α mRNA expression in surgically resected tumors of gemcitabine/cisplatin-treated NSCLC patients (p). Methods: Resected specimens were available from 57 stage IIB-IIIA-IIIB NSCLC p underwent surgery between September 1998 and December 2002 after receiving gemcitabine/platinum chemotherapy. Total RNA was recovered from formalin-fixed, paraffin-embedded surgical specimens. BRCA1 and HIF-1α mRNA expression was quantified with real-time PCR Results: Median overall survival (MOS) was 37.8 months (m) for all p, 51.9 m for p who underwent lobectomy, and 25.8 m for p who underwent pneumonectomy. Significant correlations were found between BRCA1 and HIF-1α mRNA expression (P<0.0001). 15 p in the bottom quartile of BRCA1 mRNA levels had a decreased risk of death compared to 12 p in the top quartile (P=0.008). MOS was 51.97 m for p in the bottom quartile, 12.7 m for p in the top quartile (P=0.03), and 25.8 m for 40 p in the top three quartiles (P=0.04). Lobectomy was performed more often in p in the bottom quartile (P=0.01). No significant differences were found according to HIF-1α mRNA levels Conclusions: BRCA1 expression should be assessed for predicting cisplatin resistance and tailoring chemotherapy in NSCLC. No significant financial relationships to disclose.
Abstract 1194: Comparison of Cardiovascular Disease Mortality in Young U.S. and Italian Competitive Athletes: Which Preparticipation Screening Strategy is Really More Effective?
Authors: Barry Maron, Tammy S Haas, Joseph J Doerer, Paul D Thompson, James S Hodges
Journal: Circulation (2008)

Considerable controversy has evolved regarding the most practical and effective strategy for preparticipation screening of competitive athletes to detect unsuspected cardiovascular disease and prevent sudden death on the athletic field. Screening in the Veneto region of Italy (as part of a national program), routinely using the 12-lead ECG has been reported to detect hypertrophic cardiomyopathy de novo and also decrease the overall cardiovascular death rate in young athletes. These observations have been used to suggest that the Italian screening model with ECG is superior to U.S. screening which is limited to history and physical examination. We compared cardiovascular-related death rates in the athletes of Veneto with that in a demographically similar region of the U.S. (i.e., Minnesota) over largely equivalent time periods. In Veneto, 55 sudden cardiovascular deaths were reported in athletes in 26 years (2.1/year) and in Minnesota there were 22 deaths in 23 years (0.96/year). The death rate in Veneto (1.87 deaths/100,000 person-years) exceeded Minnesota (1.06/100,000 p-y; p=0.02) for all years combined, 1979 to 2004. Over the most recent and comparable 11-year period, 1993–2004, there were 12 deaths reported in Veneto and 11 in Minnesota and the 2 regions did not differ significantly (0.87/100,000 p-y vs. 0.93/100,000 p-y, respectively; p=0.87). Also, most recently, 2001 to 2004, death rates in Veneto and Minnesota did not differ (0.43 vs. 0.90/100,000 p-y, respectively; p=0.38). Both regions had similar frequencies of death from cardiomyopathies (16% Veneto vs. 14% Minnesota; p=1.0). Similar proportions of deaths occurred during sports (91% Veneto vs. 87% Minnesota; p=0.68). Despite different preparticipation screening strategies, the rates of cardiovascular disease-related sudden deaths in demographically similar regions of the U.S. (Minnesota) and Italy (Veneto) were nevertheless particularly low, and did not different significantly over the last decade. These data are evidence that the Italian model for screening athletes with ECGs may not substantially reduce cardiovascular death rates beyond that recently achieved in Minnesota with less structured screening methodology.
Personality disorder in patients infected with HIV: a controlled study with implications for clinical care
Authors: D O Perkins, E J Davidson, J Leserman, D Liao, D L Evans
Journal: American Journal of Psychiatry (1993)

Previous studies of psychiatric illness in populations infected with or at risk for HIV have not included systematic evaluation for personality disorders. The authors present the first controlled study of 1) personality disorders in HIV-positive and HIV-negative homosexual men and 2) the impact of personality disorder on coping, social support, and mood in asymptomatic HIV-positive homosexual men.The authors studied 58 asymptomatic HIV-positive and 53 HIV-negative homosexual men living outside the high-prevalence epicenters of the AIDS epidemic. Personality disorder was assessed with a clinician-administered interview, the Structured Clinical Interview for DSM-III-R.There was a significantly higher prevalence of personality disorder in the HIV-positive (33%) than in the HIV-negative (15%) subjects. In the HIV-positive subjects, those with a personality disorder (compared to those without a personality disorder) showed 1) significantly greater mood disturbance, with higher scores on the Hamilton Rating Scale for Depression, Hamilton Rating Scale for Anxiety, Profile of Mood States Total Mood Dysfunction, and the Beck Hopelessness Scale, 2) greater use of denial and helplessness when coping with the threat of AIDS, and 3) greater social conflict.These findings suggest that personality disorder is common in the HIV-positive population. Compared with HIV-infected patients without a personality disorder, patients with a personality disorder may experience greater dysphoria and be more likely to cope with the threat of AIDS in a dysfunctional way. Recognition of the impact of personality disorder on coping with HIV infection is important for comprehensive, sensitive, and effective clinical care.
Polymorphonuclear neutrophils from human immunodeficiency virus- infected patients show enhanced activation, diminished fMLP-induced L- selectin shedding, and an impaired oxidative burst after cytokine priming
Authors: C Elbim, MH Prevot, F Bouscarat, E Franzini, S Chollet-Martin, J Hakim, MA Gougerot-Pocidalo
Journal: Blood (1994)
Abstract 1646: Differential Role and Tissue Specificity of Interleukin-1{alpha} Gene Expression on Atherogenesis and Lipid Metabolism
Authors: Dror Harats, yehuda kamari, Rachel Werman-Venkert, Aviv Shaish, Ariel Werman, Ayelet Harari, Ayelet Gonen, Elena Voronov, Ehud Grossman, Yehonatan Sharabi, Ron N Apte
Journal: Circulation (2006)
Pediatric-type sarcomas in adult patients: Age is an independent prognostic factor in IRS group I/II
Authors: J. E. Uhm, J. O. Park, J. Lee, B. B. Park, J. S. Ahn, M. J. Ahn, Y. S. Park, H. Y. Lim, Y. H. Im, W. K. Kang, K. Park
Journal: Journal of Clinical Oncology (2006)

9552 Backgrounds: A number of pediatric sarcomas occur in adults, including Ewing’s sarcoma (EWS)/primitive neuroectodermal tumor (PNET) and rhabdomyosarcoma (RMS). However, these are rare in adult patients (pts) and differ from typical adult sarcomas in that they are generally considered as systemic disease. There is debate as to whether adults do worse than pediatric pts with the same stage of disease. This study was performed to investigate whether various clinical parameters such as tumor size, primary site, age at diagnosis and response to chemotherapy predict the outcome. Methods: 74 consecutive cases of previously untreated pts over 18 years who were diagnosed with EWS/PNET, RMS, and desmoplastic small round cell tumor (SRCT) between 1995 and 2005, were identified from the database at the Samsung Medical Center. Among them, 64 pts were reviewed retrospectively and 10 pts who were lost to follow up were excluded. All pts were treated by a multimodality therapeutic approach, including surgery, chemotherapy, and radiotherapy, based on the ongoing protocols at the time of diagnosis. Results: The median age of the patients was 28 years (range, 18 - 74 years) and the majority (62.5%) of patients was male. There were 35 (54.6%) cases of EWS/PNET, 25 (39.1%) of RMS and 4 (6.3%) of desmoplastic SRCT. 29 pts (45.3%) had metastatic disease and 42 pts (65.6%) were Intergroup RMS Study (IRS) groups III/IV at diagnosis. Median overall survival was 41.5 months (95% CI, 16.1–66.9 months) and 5 years-survival rates was 38.7% (95% CI, 26.7–50.6%) in all pts. In univariate analysis, age (p=0.015), IRS group (p=0.0007) and tumor size (p=0.044) were correlated with better survival. However, multivariate analysis showed that independent variables for better survival were age (p=0.017) and IRS group (p=0.016). In subset analysis, significant statistical correlation between age and overall survival was observed in pts with IRS group I/II. Notably, pts younger than 30 years showed favorable outcome. Conclusions: In this study, age at diagnosis and IRS group reflecting tumor burden were important prognostic factors. Therefore, it is necessary that adult pts with pediatric sarcomas should be included in pediatric protocols, whenever feasible, to provide proper management for the rare disease. No significant financial relationships to disclose.
Psychological dimensions of depression in borderline personality disorder
Authors: S M Southwick, R Yehuda, E L Giller
Journal: American Journal of Psychiatry (1995)

The authors' goal was to test empirically a commonly held assumption that the depression in borderline personality disorder is primarily anaclitic.The Depressive Experiences Questionnaire and the Hamilton Rating Scale for Depression were administered to 26 patients with borderline personality disorder (16 of whom were depressed) and 12 depressed patients without borderline personality disorder.Patients with borderline personality disorder showed more self-criticism but did not endorse more anaclitic items than depressed patients without borderline personality disorder.These findings suggest that self-criticism is an underemphasized characteristic of depression in borderline personality disorder.