tbuckley/cabot-search huggingface dataset:
STUDIES ON SENSITIVITY OF DIPHTHERIA TO PENICILLIN
Authors: Ross Paull, Sidney N. Tucker, Beverley L. Holladay, Charles R. Nicewonger
Journal: Annals of Internal Medicine (1946)

Article1 March 1946STUDIES ON SENSITIVITY OF DIPHTHERIA TO PENICILLINROSS PAULL, SIDNEY N. TUCKER, BEVERLEY L. HOLLADAY, CHARLES R. NICEWONGERROSS PAULLSearch for more papers by this author, SIDNEY N. TUCKERSearch for more papers by this author, BEVERLEY L. HOLLADAYSearch for more papers by this author, CHARLES R. NICEWONGERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-3-413 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn August 1944 there was a sudden rise in the number of admissions of diphtheria cases to Letterman General Hospital from ships' hospitals and U. S. Army transports. Similar admissions after that date persisted in disconcerting numbers. Out of these cases about 12 per cent became ill the day of arrival at this hospital; about 26 per cent developed symptoms less than six days after arrival. About 62 per cent were ill while still aboard ship. The number of these cases and the number of diphtheria carriers developing posed quite a serious problem for a debarkation hospital, responsible for rapid... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication July 13, 1945. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySensitivity of diphtheria bacilli and relatedorganisms to nine antibiotics 1 March 1946Volume 24, Issue 3Page: 413-419KeywordsDiphtheriaPenicillin ePublished: 1 December 2008 Issue Published: 1 March 1946 PDF downloadLoading ...
RENAL FUNCTION IN CONGESTIVE HEART FAILURE
Authors: W B YOUMANS
Journal: Annals of Internal Medicine (1954)

Excerpt To emphasize the renal problems, congestive heart failure may be defined as a condition in which there is a decrease in the ability of the kidneys to excrete sodium chloride and water, with the result that a positive salt and water balance develops in the presence of a normal or reduced intake. In this paper some of the evidence that congestive heart failure is characterized by retention of sodium chloride and water will be presented, and then studies which serve to establish the nature of the changes in renal function will be considered. I. THE RETENTION OF SODIUM CHLORIDE AND
Abstract 4051: Prion protein and its ligand STI1/HOP modulate migration and invasion of cell lines derived from colorectal tumors
Authors: Tonielli S. Lacerda, Marcos Vinicios S. Dias, Antuani Rafael Baptistella, Fernanda S. Giudice, Bruna R. Roz, Iara S. Rodrigues, Vilma Regina Martins
Journal: Cancer Research (2014)

Abstract The colorectal cancer is the fourth most common type of cancer in the world. The search for potential molecular targets for therapy has led to the Cellular Prion Protein (PrPC) as a possible candidate. Its activity depends on the interaction with the secreted form of the stress inducible protein 1 or heat shock organizing protein (STI1/HOP). Previous results indicated the importance of the PrPC-STI1/HOP complex in proliferation of glioblastomas and invasion of melanomas. Therefore, this work aims to understand how PrPC-STI1/HOP complex can influence the migration and invasion of WiDr and HCT8 colorectal tumor cells. PrPC is equally expressed at the cell surface of both cell lines. Cell migration assays were performed using boyden chambers and recombinant STI1/HOP as chemical attractant. For invasion experiments cells were seeded on boyden chambers covered with matrigel and treated with STI1/HOP. The results showed that when stimulated with recombinant STI1/HOP, both tumor cell lines showed higher migration and invasion potentials than non-treated cells or those treated with a STI1/HOP deletion mutant for the PrPC binding domain (STI1Δ230-245). Moreover, migration and invasion mediated by PrPC-STI1/HOP complex were blocked by a STI-1/HOP (230-245) peptide, which mimics STI1 binding site to PrPC or also by a neutralizing anti-PrPC antibody. STI1/HOP is secreted in the conditioned medium (CM) within extracellular microvesicles (MVs) and WiDr cells secreted more MVs and STI1/HOP than HCT8 cells. Remarkable, HCT8 cells treated with CM or isolated MVs from WiDr cells show a higher migration than that induced when the former cells were treated with their own CM or when WiDr cells were treated with CM or MVs derived from HCT8 cells. Together, these results indicate that the PrPC-STI1/HOP complex mediate migration and invasion of colorectal tumor cells and suggest that cellular migration is dependent on the concentration of secreted MVs. The role of STI1/HOP present in MVs on cell migration is still under investigation. Citation Format: Tonielli S. Lacerda, Marcos Vinicios S. Dias, Antuani Rafael Baptistella, Fernanda S. Giudice, Bruna R. Roz, Iara S. Rodrigues, Vilma Regina Martins. Prion protein and its ligand STI1/HOP modulate migration and invasion of cell lines derived from colorectal tumors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4051. doi:10.1158/1538-7445.AM2014-4051
Potential of carbohydrate‐binding agents as therapeutics against enveloped viruses
Authors: K. O. François, J. Balzarini
Journal: Medicinal Research Reviews (2010)

Abstract Twenty‐seven years after the discovery of HIV as the cause of AIDS more than 25 drugs directed against four different viral targets (i.e. reverse transcriptase, protease, integrase, envelope gp41) and one cellular target (i.e. CCR5 co‐receptor) are available for treatment. However, the search for an efficient vaccine is still ongoing. One of the main problems is the presence of a continuously evolving dense carbohydrate shield, consisting of N ‐linked glycans that surrounds the virion and protects it against efficient recognition and persistent neutralization by the immune system. However, several lectins from the innate immune system specifically bind to these glycans in an attempt to process the virus antigens to provoke an immune response. Across a wide variety of different species in nature lectins can be found that can interact with the glycosylated envelope of HIV‐1 and can block the infection of susceptible cells by the virus. In this review, we will give an overview of the lectins from non‐mammalian origin that are endowed with antiviral properties and discuss the complex interactions between lectins of the innate immune system and HIV‐1. Also, attention will be given to different carbohydrate‐related modalities that can be exploited for antiviral chemotherapy. © 2010 Wiley Periodicals, Inc. Med Res Rev
Allergens in pepper and paprika
Authors: A. Leitner, E. Jensen‐Jarolim, R. Grimm, B. Wüthrich, H. Ebner, O. Scheiner, D. Kraft, C. Ebner
Journal: Allergy (1998)

Mugwort and birch pollen allergy are frequently associated with IgEmediated hypersensitivity to celery and spices. We analyzed 22 sera from patients with the mugwort‐birch‐celery‐spice syndrome for IgE binding to the spices pepper and paprika by immunoblotting. Immunoblot results revealed two major allergens of 28 and 60 kDa in pepper and a 23‐kDa allergen together with allergens of higher molecular weight in paprika. In immunoblot‐inhibition studies, crude mugwort, birch pollen, and celery extracts significantly reduced the IgE binding to pepper and paprika allergens. However, no inhibition was achieved with rBet v 1 and rBet v 2, suggesting that no homologs of these birch proteins act as allergens in pepper or paprika extracts, N‐terminal sequence analysis of the 14‐ and 28‐kDa pepper and 23‐kDa paprika allergens revealed no homology to known allergens. The 28‐kDa pepper allergen showed homology to a wheat germin protein, and the 23‐kDa paprika allergen was identified as a homolog of a osmotin‐like or pathogenesis‐related protein in tomato. Therefore, we conclude that the IgE cross‐reactivity in the mugwort‐birch‐celery‐spice syndrome to the spices pepper and paprika is not caused by homologs of Bet v 1 and profilin, N‐terminal amino acid sequence analysis of the main allergens in pepper and paprika indicate a relation to frequently occurring plant proteins.
Dominant Role of the ERAP1 Polymorphism R528K in Shaping the HLA–B27 Peptidome Through Differential Processing Determined by Multiple Peptide Residues
Authors: Alejandro Sanz‐Bravo, José Campos, Marina S. Mazariegos, José A. López de Castro
Journal: Arthritis & Rheumatology (2014)

To characterize the alterations, as well as their mechanisms, induced in the HLA-B27-bound peptidome expressed in live cells by the natural ERAP1 polymorphisms predisposing to ankylosing spondylitis (AS): R528K and N575D/Q725R. HLA-B*27:05-bound peptides were isolated from 3 human lymphoid cell lines expressing distinct ERAP1 variants differing at residues 528 and/or 575/725. The high-performance liquid chromatography-fractionated peptide pools were compared by mass spectrometry based on identity of molecular mass and chromatographic retention time. The relative amount of each shared peptide in any given cell line pair was estimated from the respective ion peak intensities. Peptide sequencing was also carried out by mass spectrometry. HLA-B27-bound ligands predominant in the context of the ERAP1 variant with K528 collectively showed higher molecular mass, higher frequency of N-terminal residues resistant to ERAP1, and bulkier residues downstream of the N-terminus, relative to peptides predominant in the R528 context. None of these differences were observed with ERAP1 variants differing at positions 575/725, but not at residue 528. Neither R528K nor N575D/Q725R altered the mean length of B*27:05-bound ligands. The R528K, but not the N575D/Q725R, polymorphism alters the expression levels of many HLA-B*27:05-bound peptides, depending on the susceptibility of their N-terminal residues to trimming and depending on the size of the amino acid side chains at multiple positions downstream of the N-terminus. The significant alterations in the B*27:05 peptidome and the structural features of the peptides that determine their differential expression in distinct ERAP1 contexts account for the association of the R528K polymorphism with AS.
Long-Term Follow-Up of Allogeneic Marrow Transplants in Patients With Aplastic Anemia Conditioned by Cyclophosphamide Combined With Antithymocyte Globulin
Authors: Rainer Storb, Wendy Leisenring, Claudio Anasetti, Frederick R. Appelbaum, C. Dean Buckner, William I. Bensinger, Thomas Chauncey, Reginald A. Clift, H. Joachim Deeg, Kristine C. Doney, Mary E.D. Flowers, John A. Hansen, Paul J. Martin, Jean E. Sanders, Keith M. Sullivan, Robert P. Witherspoon
Journal: Blood (1997)
PFI: perfidious financial idiocy
Authors: R. Smith
Journal: BMJ (1999)

Education and debate p 48 

> “I see the private finance initiative in very simple and personal terms. At the moment i own a beautiful but outdated home in a prime position in Edinburgh, one of the world's loveliest cities. Now i'm going to ‘give it away’ at below market value in exchange for a smaller, unglamorous modern house on the edge of the city that doesn't have enough bedrooms and is hard to reach by public transport. Worse, i'll have to pay for it for 30 years—without any option of moving elsewhere. Worse still, we will have to reduce how much we do around the home in order to pay for the new building. Worst of all, my children will find themselves years from now in an outdated building in an awful position. They won't be able to afford either a new home or the services of the home. They'll have to buy them privately.”

This is the view of one doctor in the Royal infirmary of Edinburgh of what the private finance initiative (PFi) means to him, his colleagues, and his successors. His view may simplify some of the complexities of the initiative, but it's more true than untrue. The private finance initiative is a “smoke and mirrors” policy that may destroy the NHS.1–8 The complexity of it all has left many electors …
Rationing in general practice: The Asbury draft policy on ethical use of resources
Authors: R. Crisp, T. Hope, D. Ebbs
Journal: BMJ (1996)

Many doctors find themselves torn between two contradictory principles: to do the best for the individual patient and to be responsible for an overall budget that is insufficient for the best care for each individual patient. Little guidance is available for doctors on how to resolve this conflict. Crisp et al present a draft document that one fundholding general practice has developed to clarify the ethical basis for rationing decisions. We invited three interested professionals to comment on the draft. The general practice partners invited two medical ethicists (RC and TH) to meet them to develop the document. The partners met RC and TH for one and a half hours on eight occasions over one year and met without them on eight further occasions. The entire general practice also had an all day session to discuss in detail an advanced version of the draft. The developmental process was of great value to the partnership and has led to appreciable change in individuals' views. The draft policy presented here is intended to start the ball rolling, so that proper guidelines will be developed at whatever level in the NHS is most appropriate. Comments and feedback are welcomed. #### Introduction
Abstract 12501: Integrin Overexpression Improves Survival Rate After Myocardial Infarction Through Attenuation of ER Stress
Authors: Hideshi Okada, Genzou Takemura, N Chin Lai, Ana M Manso, Takatomo Watanabe, Kentaro Morishita, Shinji Ogura, Shinya Minatoguchi, Robert S Ross
Journal: Circulation (2014)

Introduction: Alterations in calcium homeostasis in the endoplasmic/sarcoplasmic reticulum (ER) can cause stress that ultimately may affect ventricular function. Previously, we reported that α7β1D integrin modified Ca2+ regulatory pathways in the cardiomyocyte via ryanodine receptor 2 (RyR2) stabilization, and offers a means to protect the myocardium from ischemia/reperfusion injury. In the present study, we hypothesized that integrin overexpression (OE) would have beneficial effects against post-myocardial infarction (MI) left ventricular (LV) remodeling via the inhibition of ER stress. Methods: MI was created in 9-12 week old α7β1D integrin overexpressing male mice and age/gender-matched littermate controls by left coronary artery ligation. Groups were followed for 4 weeks post-MI. Results: Survival rate was significantly increased in α7β1D integrin OE mice (90% vs. control, 38.5%, p<0.05). There was no significant difference in LV fractional shortening between both groups (Control 8.7±0.4%, α7β1D 15.8±...
559. Generating Powerful Immune Responses Against Lentiviral Antigens: Using rSV40 Vector-Delivered Proinflammatory Cytokines to Potentiate Immune Responses vs. rSV40-Delivered Lentiviral Antigens
Authors: Hayley J. McKee, David S. Strayer
Journal: Molecular Therapy (2004)

Background: The importance of strong anti-lentiviral immune responses for prevention and therapy of AIDS, combined with the failure of classical immunization techniques to provide either effectively, has led to consideration of the potential utility of immunostimulatory cytokines as adjuvants in improving the magnitude and rapidity of such responses. Delivery of such cytokines, in concert with the antigen in question, might be facilitated by using recombinant Tag-deleted SV40 vectors (rSV40s). These vectors do not elicit detectable neutralizing antibody responses, and therefore can be used multiply, both to prime and boost immune responses.
VECTORS OF RICKETTSIAL DISEASES
Authors: Glen M. Kohls
Journal: Annals of Internal Medicine (1947)

Article1 May 1947VECTORS OF RICKETTSIAL DISEASESGLEN M. KOHLSGLEN M. KOHLSSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-5-713 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe vectors of the rickettsial diseases of man belong to four groups of parasites—ticks, mites, lice, and fleas.Ticks are vectors of the diseases of the spotted fever and boutonneuse fever groups and are certainly involved to some extent in Q fever. Spotted fever includes Rocky Mountain spotted fever of Canada and the United States and the spotted fevers of Mexico, Colombia, and Brazil. Present knowledge suggests that these diseases differ only in epidemiological features relating to the different vector species. Similarly, boutonneuse fever of the Mediterranean region, Kenya typhus, and South African tick-bite fever appear to be identical. They... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Sanitary Corps AUS United States Public Health Service Hamilton, Montana*Read at the Annual Session of the American College of Physicians in Philadelphia, May 17, 1946.Contribution from the Rocky Mountain Laboratory, Hamilton, Montana, Division of Infectious Diseases, National Institute of Health.†Member of the United States of America Typhus Commission. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1947Volume 26, Issue 5Page: 713-719KeywordsFeversFleasInfectious diseasesLiceMitesQ feverResearch laboratoriesRocky Mountain spotted feverTicksTyphus ePublished: 1 December 2008 Issue Published: 1 May 1947 PDF downloadLoading ...
Bristol surgeon regrets not consulting with colleagues over poor results
Authors: Clare Dyer
Journal: BMJ (1999)

James Wisheart, the senior surgeon struck off the medical register for his role in the deaths of children undergoing heart surgery at Bristol, told the public inquiry into Bristol paediatric cardiac surgery services this week that he had stopped operating on children because of stress and anxiety from seeing so many of his patients die.

Although he believed there were “true and proper” factors accounting for the deaths, the “anxiety and emotional investment or drain weighed very heavily.”The one thing he could clearly say he regretted was not consulting colleagues earlier over his disappointing results.

But he was not sure this would have led him to stop sooner.

Mr Wisheart, former medical director of United Bristol Healthcare NHS Trust, said that he stopped doing operations to correct atrioventricular septal defects in September 1994. The …
Smart Bomb for Leukemia
Authors: Brian Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meditation by the Sea
Authors: M Therese Southgate
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Recent developments: Blood transfusion medicine
Authors: F. Regan
Journal: BMJ (2002)

Background: Fewer than 1% of UK general practice consultations occur by video. Aim: To explain why video consultations are not more widely used in general practice. Design and setting: Analysis of a sub-sample of data from three mixed-method case studies of remote consultation services in various UK settings 2019-2021. Methods: The dataset included interviews and focus groups with 121 participants from primary care (33 patients, 55 GPs, 11 other clinicians, 9 managers, 4 support staff, 4 national policymakers, 5 technology industry). Data were transcribed, coded thematically and then analysed using the Planning and Evaluating Remote Consultations (PERCS) Framework. Results: With few exceptions, video consultations were either never adopted or soon abandoned in general practice despite a strong policy push, short-term removal of regulatory and financial barriers and advances in functionality, dependability and usability of video technologies (though some products remained "fiddly" and unreliable). The relative advantage of video was perceived as minimal for most of the case load of general practice, since many presenting problems could be sorted adequately and safely by telephone and in-person assessment was considered necessary for the remainder. Some patients found video appointments convenient, appropriate and reassuring but others found therapeutic presence was only achieved in person. Video sometimes added value for out-of-hours and nursing home consultations and statutory functions (e.g. death certification). Conclusion: Efforts to introduce video consultations in general practice should focus on situations where this modality has a clear relative advantage (e.g. strong patient or clinician preference, remote localities, out-of-hours services, nursing homes).
12p Abnormalities and the TEL Gene (ETV6) in Childhood Acute Lymphoblastic Leukemia
Authors: S.C. Raimondi, S.A. Shurtleff, J.R. Downing, J. Rubnitz, S. Mathew, M. Hancock, C-H. Pui, G.K. Rivera, G.C. Grosveld, F.G. Behm
Journal: Blood (1997)