CHRONIC SODIUM CHLORIDE TOXICITY: HYPERTENSION, RENAL AND VASCULAR LESIONS
Authors: G R MENEELY, R G TUCKER, W J DARBY, S H AUERBACH
Journal: Annals of Internal Medicine (1953)

Article1 November 1953CHRONIC SODIUM CHLORIDE TOXICITY: HYPERTENSION, RENAL AND VASCULAR LESIONSGEORGE R. MENEELY, M.D., F.A.C.P., ROBERT G. TUCKER, Ph.D., WILLIAM J. DARBY, M.D., Ph.D., STEWART H. AUERBACH, M.D.GEORGE R. MENEELY, M.D., F.A.C.P., ROBERT G. TUCKER, Ph.D., WILLIAM J. DARBY, M.D., Ph.D., STEWART H. AUERBACH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-5-991 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAn investigation of so common a substance as salt needs an introduction. While used in abundance by nearly all of us every day, we have certainly learned the merit of restricting it in most patients with edema, and there is a growing body of evidence of its role in hypertension.1 A spate of publications on electrolytes in recent years makes one think that nothing before ever was known about salt, and there is some danger of missing the wood for the trees.Scientific knowledge of the composition of sodium chloride did not exist earlier than 1774, when Scheele first discovered...Bibliography1. Bell ET, Editor: Hypertension. A symposium, 1951, University of Minnesota Press, Minneapolis. Google Scholar2. Waiden P: Salts, acids, and bases, 1929, McGraw-Hill, New York. Google Scholar3. Schmidt C: Charakteristik der epidemischen Cholera gegenüber verwandten Transsudationsanomalieen 1850, Eine physiologisch-chemische Untersuchung, Leipzig und Mitau. Google Scholar4. Keary CF: The dawn of history, 1921, Charles Scribners' Sons, New York. Google Scholar5. Meneely GR: Salt, Am. J. Med. (in press). Google Scholar6. Smith JR: Salt, Nutrition Rev. 11: 33, 1953. CrossrefMedlineGoogle Scholar7. Bunge G: Physiologische Chemie, 3rd Ed., 1894, Verlag von F. C. W. Vogel, Leipzig. Google Scholar8. Bunge G: in Physiological chemistry, V. C. Vaughn, 1896, F. A. Wagner, Ann Arbor, p. 9. Google Scholar9. Smith WR: Salt: ancient history and religious symbolism, Encyclopedia Britannica, 11th Ed., 24: 87, 1911, University Press, Cambridge. Google Scholar10. Hughes E: Studies in administration and finance, 1934, University of Manchester Press, Manchester. Google Scholar11. Eskew GL: Salt, the fifth element, 1948, J. G. Ferguson, Chicago. Google Scholar12. Lonn E: Salt as a factor in the Confederacy, 1933, W. Neale, New York. Google Scholar13. Bunge G: in Chemistry of food and nutrition, H. C. Sherman, 4th Ed., 1933, Macmillan, New York, p. 242. Google Scholar14. Kempner W: Treatment of kidney disease and hypertensive vascular disease with rice diet, North Carolina M. J. 5: 125, 1944. Google Scholar15. MeneelyTuckerDarby GRRGWJ: Chronic sodium chloride toxicity in the albino rat. I. Growth on a purified diet containing various levels of sodium chloride, J. Nutrition 48: 489, 1952. CrossrefMedlineGoogle Scholar16. MeneelyTuckerDarbyAuerbach GRRGWJSH: Chronic sodium chloride toxicity in the albino rat. II. Occurrence of hypertension and of a syndrome of edema and renal failure, J. Exper. Med. 98: 71, 1953. CrossrefMedlineGoogle Scholar17. Somerville L in Communications of the Board of Agriculture, Vol. II, 1814, London, p. 471. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Presented at the Thirty-Fourth Annual Session of the American College of Physicians, Atlantic City, New Jersey, April 16, 1953.From the Research Laboratory and Radioisotope Unit, Thayer Veterans Administration Hospital, and the Departments of Medicine, Biochemistry and Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee. 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R. MENEELY, M.D., F.A.C.P., C. O. T. BALL, J. B. YOUMANS, M.D., F.A.C.P.Observations on Dietary Sodium ChlorideSymposium on Nutrition and the KidneyÜber die nichteitrige Panarteriitis bei Ratten unter unspezifischer ReizbehandlungORIGINS OF MALADJUSTMENTSALT INTOXICATION? 1 November 1953Volume 39, Issue 5Page: 991-998KeywordsBiochemistryEdemaHospital medicineHypertensionLesionsPathology and laboratory medicineResearch laboratoriesSaltsSodium chlorideToxicity ePublished: 1 December 2008 Issue Published: 1 November 1953 Copyright & PermissionsCopyright, 1953, by The American College of PhysiciansPDF downloadLoading ...