THE TREATMENT OF BACTERIAL ENDOCARDITIS
Authors: E S ORGAIN, C K DONEGAN
Journal: Annals of Internal Medicine (1950)

Article1 June 1950THE TREATMENT OF BACTERIAL ENDOCARDITISEDWARD S. ORGAIN, M.D., F.A.C.P., CHARLES K. DONEGAN, M.D.EDWARD S. ORGAIN, M.D., F.A.C.P.Search for more papers by this author, CHARLES K. DONEGAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-32-6-1099 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the last decade, the introduction and practical application of new chemical and antibiotic agents in the therapy of bacterial endocarditis have altered completely the outlook in this disease which formerly was considered to be almost universally fatal. Prior to the advent of the various sulfonamide compounds, no specific therapeutic agents were available, and spontaneous recoveries ranged about 1 per cent or less. In the years 1937 to 1943, the sulfonamide drugs, alone and with supplementary forms of treatment, provided cures in but 5.5 per cent of a large series of cases collected by Lichtman.1In 1943, the National Research...Bibliography1. Lichtman SS: Treatment of subacute bacterial endocarditis: current results, Ann. Int. Med. 19: 787-793, 1943. LinkGoogle Scholar2. KeeferBlakeMarshallLockwoodWood CSFGEKJSWB: Penicillin in the treatment of infections, J. A. M. A. 122: 1217-1224, 1943. CrossrefGoogle Scholar3. LoeweRosenblattGreeneRussell LPHJM: Combined penicillin and heparin therapy of subacute bacterial endocarditis, J. A. M. A. 124: 144-149, 1944. CrossrefGoogle Scholar4. DawsonHunter MHTH: The treatment of subacute bacterial endocarditis with penicillin: results in twenty cases, J. A. M. A. 127: 128-137, 1945. Google Scholar5. 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A. 113: 1700-1702, 1939. Google Scholar37. PriestSmithMcGee WSJMCJ: The effect of anticoagulants on the penicillin therapy and the pathologic lesion of subacute bacterial endocarditis, New England J. Med. 235: 699-706, 1946. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Durham, North Carolina*Received for publication September 9, 1948.From the Departments of Medicine and Bacteriology, Duke University School of Medicine, and Duke Hospital, Durham, North Carolina. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAntimicrobial treatment of infective endocarditis caused by viridans streptococci highly susceptible to penicillin: historic overview and future considerationsThe prevention and treatment of bacterial endocarditisSUBACUTE BACTERIAL ENDOCARDITIS COMPLICATING PATENT DUCTUS ARTERIOSUS IN THE AGEDPneumococcal endocarditisTreatment of subacute bacterial endocarditis with negative blood culturesTreatment of Bacterial EndocarditisDie Therapie der Endocarditis lenta und ihre GrundlagenSubacute bacterial endocarditis 1 June 1950Volume 32, Issue 6Page: 1099-1113KeywordsAntibioticsBacterial diseasesBacteriologyDrugsEndocarditisHospital medicineSulfonamide ePublished: 1 December 2008 Issue Published: 1 June 1950 PDF downloadLoading ...