THE DISEASE SPECTRUM OF HUMAN HISTOPLASMOSIS
Authors: A CHRISTIE
Journal: Annals of Internal Medicine (1958)

Article1 September 1958THE DISEASE SPECTRUM OF HUMAN HISTOPLASMOSISAMOS CHRISTIE, M.D.AMOS CHRISTIE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-3-544 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptI cannot be sure at this time that I had ever heard of histoplasmosis when I was invited to assume the Chair of Pediatrics at Vanderbilt in 1943. It was another rare, esoteric infectious disease which I certainly never expected to see unless the academic fates took me to the tropics.As one interested in pediatrics, and particularly in the chest diseases of children, I was entirely familiar with the problem which existed in a large section of this country, to wit: "The tuberculin test is invalid as an epidemiological index of tuberculous infection." It does not react in hundreds...Bibliography1. OphulsMoffitt WHC: A new pathogenic mold, Philadelphia M. J. 5: 1471, 1900. Google Scholar2. DicksonGifford ECMA: Coccidioides infection (coccidioidomycosis), Arch. Int. Med. 62: 853, 1938. CrossrefGoogle Scholar3. Smith CE: Epidemiology of acute coccidioidomycosis with erythema nodosum ("San Joaquin" or "Valley Fever"), Am. J. Pub. Health 30: 600, 1940. CrossrefGoogle Scholar4. SmithBeardRosenbergerWhiting CERRHGEG: Effect of season and dust control on coccidioidomycosis, J. A. M. A. 132: 833, 1946. CrossrefMedlineGoogle Scholar5. SmithBeardWhitingRosenberger CERREGHG: Varieties of coccidioidal infection in relation to the epidemiology and control of the diseases, Am. J. Pub. Health 36: 1394, 1946. CrossrefGoogle Scholar6. Smith CE: Coccidioidomycosis, M. Clin. North America 27: 790, 1943. CrossrefGoogle Scholar7. SchwarzBaum JGL: The history of histoplasmosis, 1906-1956, New England J. Med. 256: 253 (Feb. 7) 1957. CrossrefMedlineGoogle Scholar8. Darling ST(a) : Protozoan general infection producing pseudotubercles in the lungs and focal necrosis in the liver, spleen and lymph nodes, J. A. M. A. 46: 1283, 1906. (b) Darling, S. T.: Notes on histoplasmosis: a fatal disorder met with in tropical America, Maryland M. J. 50: 125, 1907. (c) Darling, S. T.: A fatal infectious disease resembling kala-azar found among natives of tropical America, Arch. Int. Med. 2: 107, 1908. CrossrefGoogle Scholar9. WatsonRiley CJWA(a) : A case of histoplasmosis originating in Minnesota, Arch. Path. 1: 667, 1926. (b) Riley, W. A., and Watson, C. J.: Darling's histoplasmosis in the United States: the possibility of further occurrence of cases, Minnesota Med. 9: 97, 1926. (c) Riley, W. A., and Watson, C. J.: Histoplasmosis of Darling: case originating in Minnesota, Am. J. Trop. Med. 6: 271, 1926. (d) Watson, C. J.: The pathology of histoplasmosis (Darling) with special reference to the origin of the phagocytic cells, Folia haemat. 37: 70, 1928. Google Scholar10. Demonbreun WA: The cultivation and cultural characteristics of Darling's Histoplasma capsulatum , Am. J. Trop. Med. 14: 93, 1934. CrossrefGoogle Scholar11. ChristiePeterson AJC(a) : Pulmonary calcification in negative reactors to tuberculin, Am. J. Pub. Health 35: 1131, 1945. (b) Christie, A.: Histoplasmosis and pulmonary calcification, Ann. New York Acad. Sc. 50: 1283, 1950. (c) Christie, A.: The disease spectrum of human histoplasmosis, Tr. A. Am. Physicians 64: 147, 1951. CrossrefGoogle Scholar12. Palmer CE: Nontuberculous pulmonary calcification and sensitivity to histoplasmin, Pub. Health Rep. 60: 513, 1945. CrossrefMedlineGoogle Scholar13. ShapiroLuxSprofkin JLJJB: Histoplasmosis of the central nervous system, Am. J. Path. 31: 319, 1955. MedlineGoogle Scholar14. ZeidbergGassHutcheson LDRSRH: The placental transmission of histoplasmosis complement-fixing antibodies, Am. J. Dis. Child. 94: 179, 1957. Google Scholar15. CurtisGrekin ACJN: Histoplasmosis: review of cutaneous and adjacent mucous membrane manifestation with report of 3 cases, J. A. M. A. 134: 1217-1224, 1947. CrossrefMedlineGoogle Scholar16. MayerEismanGefticKonopkaTanzola RLPCSEJ: Sulfonamides and experimental histoplasmosis, Antibiotics and Chemotherapy 6: 215 (Mar.) 1956. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Nashville, Tennessee*Presented as the John Phillips Memorial Lecture at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, April 28, 1958.From the Department of Pediatrics, Vanderbilt University School of Medicine.Requests for reprints should be addressed to Amos Christie, M.D., Department of Pediatrics, Vanderbilt University School of Medicine, Nashville 5, Tennessee. 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UTZ, M.D., ALBERT TREGER, M.D. 1 September 1958Volume 49, Issue 3Page: 544-555KeywordsChildrenEpidemiologyHistoplasmosisPediatric infectionsPediatricsSulfonamideThoraxTuberculin testsTuberculosisUlcers ePublished: 1 December 2008 Issue Published: 1 September 1958 PDF downloadLoading ...