Adrenocortical and Pituitary Responsiveness Following Long-term, High Dosage Corticotropin Administration
Authors: PETER I. REED
Journal: Annals of Internal Medicine (1964)

Article1 July 1964Adrenocortical and Pituitary Responsiveness Following Long-term, High Dosage Corticotropin AdministrationPETER I. REED, M.D., M.R.C.P., CHARLES B. CLAYMAN, M.D., F.A.C.P., WALTER L. PALMER, M.D., PH.D., M.A.C.P.PETER I. REED, M.D., M.R.C.P.Search for more papers by this author, CHARLES B. CLAYMAN, M.D., F.A.C.P.Search for more papers by this author, WALTER L. PALMER, M.D., PH.D., M.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe purpose of this study was to investigate the effect of prolonged administration of corticotropin in high dosage on the function of the adrenal cortex and the pituitary gland. More information is available on the action of the adrenal steroids (1-9), than on that of adrenocorticotrophic hormone (ACTH) (10-12).Thirteen patients with chronic ulcerative colitis or regional enteritis had been receiving ACTH for months and years, in two instances, over 8 and 9 years, respectively.METHODS AND MATERIALS1. The daily morning administration of ACTH (usually between 8:30 and 10:00 AM) was continued throughout the test period. Adrenal reserve was...References1. CARREONCANARYMEYERKYLE GGJJRJLH: Adrenocortical function after long-term corticoid therapy. J. Lab. Clin. Med. 56: 235, 1960. MedlineGoogle Scholar2. ANDERSSONKJERULF EK: Adrenal cortical function during steroid therapy. Acta Med. Scand. 169: 577, 1961. CrossrefMedlineGoogle Scholar3. PARIS J: Pituitary-adrenal suppression after protracted administration of adrenal cortical hormones. Proc. Mayo Clin. 36: 305, 1961. MedlineGoogle Scholar4. 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LIDDLEISLANDLANCEHARRIS GWDEMAP: Alterations of adrenal steroid patterns in man resulting from treatment with a chemical inhibitor of 11B-hydroxylation. J. Clin. Endocr. 18: 906, 1958. CrossrefMedlineGoogle Scholar22. LIDDLEESTEPKENDALLWILLIAMSTOWNES GWHLJWWCAW: Clinical application of a new test of pituitary reserve. J. Clin. Endocr. 19: 875, 1959. CrossrefMedlineGoogle Scholar23. MELBY JC: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, IllinoisFrom the Department of Medicine, The University of Chicago, Chicago, Illinois.These patients were studied in the Clinical Research Center which is supported by grant OG-37, United States Public Health Service.Presented in part before the Chicago Society of Internal Medicine, December 17, 1962, and before the Fall Meeting of the American College of Physicians, Detroit, Michigan, November 23, 1963.Requests for reprints should be addressed to Walter L. Palmer, M.D., 1320 East 58th Street, Chicago, Illinois 60637.*ACTH (Lot #119767) used in these studies was kindly supplied by Dr. S. W. Hier of the Wilson Laboratories, Chicago, Illinois.†An amphenone analog, 2-methyl-1,2-bis-(3-pyridyl)-1-propanone, was kindly supplied by Dr. C. H. Sullivan, Ciba Pharmaceutical Co., Summit, New Jersey (Lot #261520). 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