ANALGESIC PROPERTIES OF MIXTURES OF CHLORPROMAZINE WITH MORPHINE AND MEPERIDINE
Authors: G L JACKSON, D A SMITH
Journal: Annals of Internal Medicine (1956)

Article1 October 1956ANALGESIC PROPERTIES OF MIXTURES OF CHLORPROMAZINE WITH MORPHINE AND MEPERIDINEGEORGE L. JACKSON, M.D., DAVID A. SMITH, M.D.GEORGE L. JACKSON, M.D.Search for more papers by this author, DAVID A. SMITH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-4-640 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptClinical observations of the enhanced effectiveness of narcotics given with chlorpromazine have been reported by several investigators.1, 2, 3, 4, 5, 6 These reports suggest that one may anticipate more complete and longer lasting relief from pain as a result of concomitant administration of these agents. Because of its potential value in reducing the amount of analgesic required, it seemed advisable to subject this observation to controlled clinical testing.Accordingly, the following experiments were designed to determine:1. Whether the method of testing would yield results comparable to those reported by Beecher and his associates relative to the analgesic properties...Bibliography1. CourvoisierFournel SJ: Proprietes pharmacodynamiques du chlorhydrate de chloro-3 (dimethylamino-3′ propyl)-10 phenothiazine (4560 R.P.); étude experimentale d'un nouveau corps utilise dans l'anesthesie potentialisée et dans l'hibernation artificielle, Arch. internat. de pharmacodyn. et de therap. 92: 305, 1953. MedlineGoogle Scholar2. LaboritJaulmesBenitte HACA: Quelques aspects experimentaux de l'hibernation artificielle, Anesth. et analg. 9: 232, 1952. Google Scholar3. LucasAlbertBatemanKlopp JSNJCCT: Thorazine as an aid in management of cancer patients, Proc. Am. A. Cancer Res. 1: 30, 1954. 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MedlineGoogle Scholar9. KeatsBeecher AHK: Pain relief with hypnotic doses of barbiturates and hypothesis, J. Pharmacol. and Exper. Therap. 100: 1, 1950. MedlineGoogle Scholar10. LasagnaBeecher LHK: The analgesic effectiveness of codeine and meperidine (Demerol), J. Pharmacol. and Exper. Therap. 112: 306, 1954. MedlineGoogle Scholar11. Lee LE: Studies of morphine, codeine and their derivatives. XVI. Clinical studies of morphine, methyldihydro-morphinone (Metopon) and dihydrodesoxy-morphine-D (Desmorphine), J. Pharmacol. and Exper. Therap. 75: 161, 1942. Google Scholar12. DobkinGilbertLamoureaux ABRGL: Physiological effects of chlorpromazine, Anesthesia 9: 157, 1954. CrossrefMedlineGoogle Scholar13. Reckless D: Potentiation, Anesthesia 9: 288, 1954. CrossrefMedlineGoogle Scholar14. Personal communication from Chemistry Section, Smith, Kline & French Laboratories, Philadelphia, Pennsylvania. Google Scholar15. Lasagna L: Statistics, sophistication, sophistry and sacred cows, Clin. Res. Proc. 3: 185, 1955. Google Scholar16. Starr I: The significance of facts (Guest Editorial), J. A. M. A. 160: 672, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Harrisburg, Pennsylvania*Presented at the Thirty-seventh Annual Session of The American College of Physicians, Los Angeles, California, April 20, 1956.Requests for reprints should be addressed to G. L. Jackson. M.D., 1919 North Front Street, Harrisburg, Pennsylvania. 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