tbuckley/cabot-search huggingface dataset:
Does respiratory irregularity contribute to the pathogenesis of sleep-disordered breathing in multiple system atrophy?
Authors: Satoshi Hokari, Hideaki Nakayama, Takayuki Matsuto, Takayoshi Shimohata, Toshinori Takada, Tetsutaro Ozawa, Masatoyo Nishizawa, Eiichi Suzuki, Ichiei Narita
Journal: European Respiratory Journal (2011)

Background: Multiple system atrophy (MSA) is the neurodegenerative disease characterized by autonomic failure, parkinsonism, and cerebellar ataxia in various combinations, and has high frequency of sleep-disordered breathing (SDB), which caused by dysregulation of respiratory control.

Aims: This study investigates whether respiratory irregularity is involved in the development of SDB with MSA.

Methods: 22 MSA patients (9men, 60.0±6.2 years, BMI 23.1±5.0 kg/m2) were enrolled from January 2007 to June 2010. We performed polysomnography (PSG) and laryngoscopy under propofol sedation. Respiratory irregularity was assessed by approximate entropy (ApEn) of respiratory movement, which is a measure of system complexity (Pincus SM. Proc Natl Acad Sci USA 1991), evaluated from the three-minute data of respiratory movement before falling asleep in PSG (Burioka N, et al. Chest 2003). We chose the age-, sex-, and apnea-hypopnea index (AHI)-matched controls from ordinary obstructive sleep apnea (OSA) patients (BMI 27.6±4.5 kg/m2).

Results: PSG demonstrated that all MSA patients fulfilled OSA criteria, and their AHI was 40.6±26 per hour. Laryngoscopy showed that 15 patients (68%) had vocal cord abductor paralysis (VCAP). In the MSA group, there was a significant correlation between AHI and ApEn of respiratory movement (r=0.63, p<0.01). However, AHI had no correlation with age, BMI, duration and severity of MSA, degree of VCAP, and any respiratory parameters. In the control group, their AHI significantly correlated with BMI (r=0.68, p<0.01), but not with ApEn.

Conclusions: This study raises the possibility that respiratory irregularity influence the severity of SDB in MSA.
Perinatal and maternal outcomes by planned place of birth for healthy women with low risk pregnancies: the Birthplace in England national prospective cohort study
Authors: Peter Brocklehurst, Pollyanna Hardy, Jennifer Hollowell, Louise Linsell, Alison Macfarlane, Christine McCourt, Neil Marlow, Alison Miller, Mary Newburn, Stavros Petrou, David Puddicombe, Maggie Redshaw, Rachel Rowe, Jane Sandall, Louise Silverton, Mary Stewart
Journal: BMJ (2011)

<b>Objective</b> To compare perinatal outcomes, maternal outcomes, and interventions in labour by planned place of birth at the start of care in labour for women with low risk pregnancies. <b>Design</b> Prospective cohort study. <b>Setting</b> England: all NHS trusts providing intrapartum care at home, all freestanding midwifery units, all alongside midwifery units (midwife led units on a hospital site with an obstetric unit), and a stratified random sample of obstetric units. <b>Participants</b> 64 538 eligible women with a singleton, term (≥37 weeks gestation), and “booked” pregnancy who gave birth between April 2008 and April 2010. Planned caesarean sections and caesarean sections before the onset of labour and unplanned home births were excluded. <b>Main outcome measure</b> A composite primary outcome of perinatal mortality and intrapartum related neonatal morbidities (stillbirth after start of care in labour, early neonatal death, neonatal encephalopathy, meconium aspiration syndrome, brachial plexus injury, fractured humerus, or fractured clavicle) was used to compare outcomes by planned place of birth at the start of care in labour (at home, freestanding midwifery units, alongside midwifery units, and obstetric units). <b>Results</b> There were 250 primary outcome events and an overall weighted incidence of 4.3 per 1000 births (95% CI 3.3 to 5.5). Overall, there were no significant differences in the adjusted odds of the primary outcome for any of the non-obstetric unit settings compared with obstetric units. For nulliparous women, the odds of the primary outcome were higher for planned home births (adjusted odds ratio 1.75, 95% CI 1.07 to 2.86) but not for either midwifery unit setting. For multiparous women, there were no significant differences in the incidence of the primary outcome by planned place of birth. Interventions during labour were substantially lower in all non-obstetric unit settings. Transfers from non-obstetric unit settings were more frequent for nulliparous women (36% to 45%) than for multiparous women (9% to 13%). <b>Conclusions</b> The results support a policy of offering healthy women with low risk pregnancies a choice of birth setting. Women planning birth in a midwifery unit and multiparous women planning birth at home experience fewer interventions than those planning birth in an obstetric unit with no impact on perinatal outcomes. For nulliparous women, planned home births also have fewer interventions but have poorer perinatal outcomes.
A memorable patient: An aunt without health insurance
Authors: B. Blomberg
Journal: BMJ (2003)

Although she was only 44 years old, Mamdogo (“aunt” in Swahili) walked slowly towards us at Bergen Airport. She was definitely not the same Mamdogo I had met a few months earlier in Singida in central Tanzania. My wife, who is of Tanzanian origin, had insisted that we should invite her favourite Mamdogo to our home in Norway. I had agreed, remembering the happy times we had spent with her in Tanzania.

But, instead of going to the fjords and other attractions, Mamdogo was now lying on the sofa in our flat day after day. I knew that she had suffered from kanda ya jeshi (the “military belt,” Swahili slang for herpes zoster) a few years back, but I was surprised how fast she had deteriorated. I realised that her cough might be due to tuberculosis, and this …
805. Efficient Transduction of Human Cord Blood and Adult Peripheral Blood CD34+ Progenitors with HSV-1 Derived Amplicon Vectors
Authors: Martin Krahn, Anne-Marie Imbert, Catherine Badens, Cecile Zaupa, Alberto Epstein, Christian Chabannon, Michel Fontes
Journal: Molecular Therapy (2004)

Top of pageAbstract
Amplicons are promising helper-dependent HSV-1-derived vectors that allow the transfer and expression of large DNA fragments into dividing and quiescent cells. Their capacity to transduce human hematopoietic progenitors has been poorly evaluated so far. We here describe the use of an improved HSV-1 Amplicon Vector to genetically modify human CD34+ blood progenitor cells. This improved packaging system allows for the production of high titers of amplicon vectors with low levels of fully defective, non pathogenic helper contamination. The EGFP-HSV-1 Amplicon vector was used to infect immuno-selected human CD34+ progenitor cells obtained from umbilical cord or mobilized peripheral blood cell samples. Without pre-stimulation of CD34+ cells, the transduction efficiency ranged from 1 to 10%, as determined by FACS analysis. In culture conditions that stimulate CD34+ blood progenitor cells to divide while maintaining cell pluripotency, and in the presence of fibronectin, more than 40% of CD34+ cells were transduced at a MOI of 50. Mature and immature phenotypically defined subsets of CD34+ cells were transduced. The transduced cells were viable and could be sorted by flow cytometry. GFP+ cells were able to produce colonies in clonogenic cultures and to engraft NOD-SCID mice after sub-lethal irradiation, suggesting that true progenitor cells had been targeted by the vector. It makes from HSV derived vectors a promissing tool for gene transfer in hematopoietic stem cells.
Abstract 166: Short-Term Total Myocardial Ischemia Solely Does Not Cause Significant Myocardial Injury
Authors: Atsushi Mizuno, Koichiro Niwa
Journal: Circulation (2011)

Introduction; In out-of-hospital cardiac arrest patients, there is no data about myocardial injury of total myocardial ischemia due to cardiac arrest. Late gadolinium enhancement (LGE) magnetic res...
At Polio's End Game, Strategies Differ
Authors: B Vastag
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patients with cancer do not seek pain relief in Hungary
Authors: Carl Kovac
Journal: BMJ (2001)

The majority of the estimated 200 000 people with cancer in Hungary are unaware that their pain can be effectively controlled or are reluctant to seek relief, according to a survey of 142 patients across the country which was conducted by the Hungarian Anticancer League.

Dr Arturne Vasvary, secretary general of the league, said that 83% of the country's patients with cancer “constantly suffer pain and don't think there is any relief [available].”

The survey used international data to emphasise that pain can be alleviated in 95% of cases of cancer; 80% of the time it can be controlled by drug treatment and …
An analysis of respiratory health in a cohort of villagers exposed to biomass fuel
Authors: Dushantha Madegedara, Sumedha Samankantha, Damith Nandadewe, Tharanga Wijethilake, Kavinda Amerasinghe, Nalaka Egodawela
Journal: European Respiratory Journal (2014)

Introduction:  There is increasing evidence for a possible association between chronic obstructive pulmonary disease (COPD) and the use of biomass fuels for cooking in developing countries. Data on the prevalence of COPD among these populations have not been widely available from Sri Lanka.   Objective : To investigate the prevalence of COPD in a rural community that use biomass fuel and to assess their lung functions.   Method:  A cross sectional descriptive study. All females in the village using biomass fuel for cooking were screened using an interviewer administered questionnaire and spirometry was performed on all of them using Spirolab 111® portable spirometer.   Results:  70 people were screened. Mean age was 45.34 (23 to 65) years. All were non smokers. 56 (80%) had respiratory symptoms. Out of those 17(30%) cough, 28 (50%) breathlessness on exertion and 11(20%) wheeze. 10 were diagnosed patients with asthma. Mean duration of exposure was 30.9 years with 32 (45.71%) having more than thirty years of exposure. It was noted that this exposure was intermittent, being exposed only during the time of cooking. Also the cooking conditions were such that the exposure was minimal. Except for the known asthmatics all others had normal spirometry.   Conclusion:  The study population did not have a single case of COPD despite having a significant duration of exposure to biomass fuel. However, majority of the population demonstrated respiratory symptoms. This could be due to symptoms being subjective and not severe enough to cause physiological abnormalities (lung Functions). Also the exposure pattern could have contributed to the non development of COPD.
Cost-effectiveness of Breast Magnetic Resonance Imaging to Screen
Authors: Pavel Crystal
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 15251: Systemic Maternal Inflammation and Neonatal Hyperoxia Induce Remodeling and Left Ventricular Dysfunction in Mice
Authors: Markus Velten, Kirk R Hutchinson, Matthew W Gorr, Loren E Wold, Pamela A Lucchesi, Lynette K Rogers
Journal: Circulation (2011)

Markus Velten, 2011 Finalist and Presenting Author
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
Authors: Taija Mäkinen, Lotta Jussila, Tanja Veikkola, Terhi Karpanen, Mikko I. Kettunen, Kalevi J. Pulkkanen, Risto Kauppinen, David G. Jackson, Hajime Kubo, Shin-Ichi Nishikawa, Seppo Ylä-Herttuala, Kari Alitalo
Journal: Nature Medicine (2001)
Abstract 12035: Cytochrome P450 Polymorphism and Endothelial Dysfunction Additively Correlates With Adverse Cardiovascular Events in Patients With Coronary Heart Disease
Authors: Noriaki Tabata, Seiji Hokimoto, Tomonori Akasaka, Yuichiro Arima, Koichi Kaikita, Kazuko Nakagawa, Hisao Ogawa
Journal: Circulation (2014)

Introduction: CYP2C19 polymorphism correlates with adverse cardiovascular events in patients following coronary stent implantation. Endothelial dysfunction has recently been reported to predict clinical outcome in coronary heart disease patients. Hypothesis: We hypothesized that additional evaluation of endothelial function to CYP2C19 polymorphism would further improve risk stratification. Methods: We enrolled 434 patients after coronary stents. All patients received aspirin and clopidogrel. CYP2C19 genotype was examined, and we defined Carrier as having at least one loss-of-function (LOF) allele. Peripheral endothelial function by reactive hyperemia peripheral arterial tonometry (RH-PAT) was examined, and we used the median value of RH-PAT index (RHI) to divide subjects into low and high RHI. Thus, subjects were divided into four groups: Carrier, low RHI, (n=135), Carrier, high RHI (n=150), non-Carrier, low RHI (n=82), and non-Carrier, high RHI (n=67). The endpoint was a composite of cardiovascular death...
A preliminary report of a phase II study of weekly topotecan in platinum-sensitive recurrent ovarian and peritoneal carcinoma
Authors: M. Rodriguez, M. W. Method, G. Lewandowski, L. Vaccarello, R. H. Ansari
Journal: Journal of Clinical Oncology (2004)

5063 Background: Topotecan 1.5 mg/m2 on days 1 through 5 of a 21-day cycle is an established chemotherapeutic regimen for recurrent ovarian cancer. However, noncumulative myelosuppression has limited topotecan's use in some patients (pts). Topotecan on a weekly schedule has been reported to be active in recurrent ovarian cancer pts with significantly reduced hematologic toxicity. The aim of this trial is to evaluate the safety and antitumor activity of weekly topotecan in pts with platinum-sensitive recurrent ovarian and peritoneal carcinoma. Methods: A prospective multi-institutional study began in July 2002 and is ongoing. Pts were required to have recurrent platinum-sensitive disease and no more than 2 prior treatment regimens. Topotecan was given at a dose of 4 mg/m2 on days 1, 8, and 15 of a 28-day cycle and escalated to 5 mg/m2 if well tolerated. Results: To date, 21 pts, 18 with ovarian and 3 with peritoneal carcinoma, have been enrolled. Fifteen are evaluable for toxicity and response. Four have just enrolled, 1 pt died before tumor reassessment, and 1 pt received only 1 cycle of therapy because of unrecovered blood counts. At study entry, the median age was 65 years (range, 43 to 82), median performance status was 0, and median number of prior regimens was 1. Pts received a median of 2 (range, 1 to 8) courses of topotecan. The overall response rate was 20% (3/15, all partial responses). An additional 6 (40%) pts had stable disease. Mean time to progression for responders and pts with stable disease was 26.4 (range, 25.6 to 26.8) and 16.6 (range, 10.7 to 30.7) weeks, respectively. Grade 4 neutropenia and anemia occurred in 2 pts (13.3%) and 1 pt (6.7%), respectively. No pts had grade 4 thrombocytopenia or neutropenic fever. G-CSF was used in 1 pt (6.7%) and erythropoietin was used in 6 pts (40%). Conclusions: Weekly topotecan in this setting is active with significant reductions in hematologic toxicity. Future studies using weekly topotecan in combination with other chemotherapeutic agents seem feasible given the low levels of hematologic toxicity observed in our trial. Further studies are being conducted to confirm these preliminary results. No significant financial relationships to disclose.
Autoimmune cytopenias in chronic lymphocytic leukemia
Authors: Carlo Visco, Wilma Barcellini, Francesco Maura, Antonino Neri, Agostino Cortelezzi, Francesco Rodeghiero
Journal: American Journal of Hematology (2014)

Chronic lymphocytic leukemia (CLL) is frequently complicated by secondary autoimmune cytopenias (AIC) represented by autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), pure red cell aplasia, and autoimmune granulocytopenia. The distinction of immune cytopenias from cytopenias due to bone marrow infiltration, usually associated with a worse outcome and often requiring a different treatment, is mandatory. AIHA and ITP are more frequently found in patients with unfavorable biological risk factors for CLL. AIC secondary to CLL respond less favorably to standard treatments than their primary forms, and treating the underlying CLL with chemotherapy or monoclonal antibodies may ultimately be necessary. Am. J. Hematol. 89:1055–1062, 2014. © 2014 Wiley Periodicals, Inc.
Carcinogenesis in the Mouse's Skin by the Infrequent Application at Long Intervals of Methylcholanthrene
Authors: William Cramer, Robert E. Stowell
Journal: Cancer Research (1941)

This paper is a contribution to a group investigation on the early stages of experimental carcinogenesis organized by Dr. E. V. Cowdry. From a histological study of the early changes produced by a strong carcinogenic stimulus as represented by a o.6 per cent solution of methylcholanthrene in benzene applied to a large area of skin 3 tin-ms a week, the conclusion was reached that the action of the carcinogen is not a direct stimulating effect inducing epithelial proliferation. Its direct effect is, on the contrary, a short toxic one lasting for several days, injuring the epithelial cells and inhibiting their mitotic activity. The subsequent epithelial proliferation which conveys the impression of a protective response can be accounted for adequately by assuming as a working hypothesis the formation in the skin of substances stimulating the cells to multiply over a prolonged period. For convenience of reference we shall call these hypo. thetical substances proliferin. This conclusion was based partly on the finding that a single application of methylcholanthrene is capable of inducing in a small percentage of a group of mice an active epithelial proliferation which persists for many weeks producing a massive hyperplasia, while it fails to do so in other animals of the same strain subjected for a period of i or 2 months to frequently repeated applications of the carcinogen (Figs. i and 2). The detailed evidence on which these conclusions are based is now being prepared for publication. If the carcinogen had a direct stimulating effect on the epithelium, as is generally believed, then the degree of the epithelial hyperplasia should be a direct function of the amount of the carcinogen applied. This is
Abstract 1577: Variability of Serial Left Atrial Volume Index Measurements by 2-D Echo in a Randomized Clinical Trial: An Echo Core Lab Study
Authors: Ryan P Daly, Neil L Greenberg, Jane A Harness, Allen Borowski, Jeanne Drinko, Maureen Martin, Srikanth Sola, Annitta Morehead, Allan L Klein
Journal: Circulation (2007)
WEBER-CHRISTIAN'S DISEASE: REPORT OF A CASE
Authors: I L BUNNELL, D S LEVY
Journal: Annals of Internal Medicine (1948)

Case Reports1 January 1948WEBER-CHRISTIAN'S DISEASE: REPORT OF A CASEIVAN L. BUNNELL, M.D., DEXTER S. LEVY, M.D.IVAN L. BUNNELL, M.D.Search for more papers by this author, DEXTER S. LEVY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-1-169 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWeber-Christian's disease, or relapsing febrile nodular, non-suppurative panniculitis, is a disease of unknown cause, characterized by the appearance of crops of inflammatory and necrotic subcutaneous nodules chiefly on the arms, legs, and trunk and by a definite constitutional reaction. The disease commonly affects young women and generally results in recovery, but runs a protracted course, which may last from one month to 15 years. There are no characteristic laboratory findings. The nodules may regress with fibrosis and atrophy at the original site. A recent review of the literature1reveals 28 recorded cases of Weber-Christian's disease, and more recently, a few...Bibliography1. LARKINDE SANCTISMARGULIS VDAGAE: Relapsing febrile nodular nonsuppurative panniculitis (Weber-Christian's disease), Am. Jr. Dis. Child., 1944, lxvii, 120. CrossrefGoogle Scholar2. SPAINFOLEY DMJM: Nonsuppurative nodular panniculitis (Weber-Christian's disease), Am. Jr. Path., 1944, xx, 783. Google Scholar3. FRIEDMAN NB: Fatal panniculitis, Arch. Path., 1945, xxxix, 42. Google Scholar4. SHAFFER B: Liquefying nodular panniculitis: report of a case, Arch. Derm. and Syph., 1938, xxxviii, 535. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Buffalo, New York*Received for publication July 29, 1946.From the Department of Medicine, Edward J. Meyer Memorial Hospital, and University of Buffalo, School of Medicine, Buffalo, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEntzündliche Erkrankungen des UnterhautbindegewebesA case of Weber-Christian disease with roentgenographically demonstrable mammary calcificationsPostpartum heart diseaseZum Krankheitsbild der idiopathischen PanniculitisNodular Nonsuppurative Panniculitis (Weber-Christian Syndrome) with Relapsing Uveitis*Lipophagic GranulomaWEBER-CHRISTIAN DISEASE WITH BONE INVOLVEMENT*C. J. DELOR, M.D., F.A.C.P., R. W. MARTZ, M.D.ROYAL SOCIETY OF MEDICINESection of DermatologyRELAPSING FEBRILE NODULAR NONSUPPURATIVE PANNICULITIS (WEBER-CHRISTIAN DISEASE); REVIEW OF LITERATURE AND REPORT OF CASE*JOHN D. HALLAHAN, M.SC., M.D., THOMAS KLEIN, M.D., F.A.C.P. 1 January 1948Volume 28, Issue 1Page: 169-172KeywordsAtrophyBiopsyFibrosisHospital medicineResearch laboratories ePublished: 1 December 2008 Issue Published: 1 January 1948 PDF downloadLoading ...