tbuckley/cabot-search huggingface dataset:
INSTANT DEATH IN BACTERIAL ENDOCARDITIS: REPORT OF A CASE WITH MYCOTIC ULCERATION OF THE CONDUCTION SYSTEM
Authors: John G. Kidd
Journal: Annals of Internal Medicine (1935)

Case Reports1 July 1935INSTANT DEATH IN BACTERIAL ENDOCARDITIS: REPORT OF A CASE WITH MYCOTIC ULCERATION OF THE CONDUCTION SYSTEMJOHN G. KIDD, M. D.JOHN G. KIDD, M. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-9-1-78 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSudden death, as it occurred in the present instance, is not the rule in subacute bacterial endocarditis. Such unexpected death contrasts sharply with the usual protracted course of this disease, so ably described by the late Dr. William Sidney Thayer in his remarkable monograph1:The disease is often distressingly chronic. Days and weeks and months pass by—every day with its morning of hope and its evening of depression. And the fatigue and the fever and the anorexia continue—moments, days, even weeks of apparent improvement and elation fatally dispelled by ever-recurring aggravations of first one, then another symptom. And slowly and...References1. THAYER WS: Studies on bacterial (infective) endocarditis, Johns Hopkins Hosp. Rep., 1926, xxii, 1-184. Google Scholar2. ROSENTHAL SR: Branch arborization and complete heart block, Arch. Int. Med., 1932, l, 730-758. CrossrefGoogle Scholar3. ROTHSCHILDSACKSLIBMAN MABE: Disturbances of cardiac mechanism in subacute bacterial endocarditis and rheumatic fever, Am. Heart Jr., 1927, ii, 356-374. CrossrefGoogle Scholar4. WHITE PD: Heart disease, 1931, Macmillan, New York, p. 350. Google Scholar5. BLUMER G: Subacute bacterial endocarditis, Medicine, 1923, ii, 105-170. CrossrefGoogle Scholar6. WILSON CP: Mycotic aneurysm involving intraventricular septum, Am. Heart Jr., 1926, i, 703-706. CrossrefGoogle Scholar7. STENSTROM N: Recovery from complete a-v block in case of endocarditis with postmortem examination, Acta med. Scandinav., 1927, lxvii, 185-188. Google Scholar8. SPALTEHOLZ W: Hand-atlas of human anatomy, 1923, J. B. Lippincott, Philadelphia, 5th ed., ii, p. 389a. Google Scholar9. LEWIS T: Mechanism and graphic registration of the heart beat, 1920, Paul B. Hoeber, New York, pp. 4-5. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOHN G. KIDD, M. D.Affiliations: Detroit, Michigan*Received for publication August 14, 1934.From the Department of Medicine of the Henry Ford Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySOLITARY MYOCARDIAL ABSCESS IN SUBACUTE BACTERIAL ENDOCARDITIS*ADOLPH R. BERGER, M.D., F.A.C.P., CHARLES E. KOSSMANN, M.D., F.A.C.P. 1 July 1935Volume 9, Issue 1 Page: 78-84 Keywords Endocarditis Fatigue Fevers Hospital medicine Ulcers ePublished: 1 December 2008 Issue Published: 1 July 1935 PDF downloadLoading ...
Malaria Susceptibility Heightened for Some
Authors: Tracy Hampton
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Microbial content of drinking water in Finnish and Russian Karelia – implications for atopy prevalence
Authors: L. Von Hertzen, T. Laatikainen, T. Pitkänen, T. Vlasoff, M. J. Mäkelä, E. Vartiainen, T. Haahtela
Journal: Allergy (2007)

Background and aim: The influence of microbial quality of drinking water from different sources on the occurrence of atopy has been poorly examined. This study was undertaken to clarify the association between the overall microbial content in drinking water and the occurrence of atopy among schoolchildren from two neighbouring areas with profound differences in living conditions and lifestyles. Methods: Drinking water samples were obtained from kitchens of nine schools in North Karelia, Finland and of nine schools from Pitkäranta, the Republic of Karelia, Russia. The pupils of these schools were participants of the Karelian Allergy Study. Occurrence of atopy, determined by skin prick test positivity (one or more) to 14 common airborne and food allergens, was measured in all 563 children, aged 7–16 years, from these 18 schools. Water samples were analysed using standard methods for drinking water analyses including viable counts for Escherichia coli , intestinal enterococci, coliform bacteria and heterotrophic bacteria. In addition, total cell counts including both viable and nonviable bacteria, algae and protozoans were assessed using epifluorescence microscope with 4′‐6‐diamidino‐2‐phenylindole (DAPI) staining. Results: In Finland, 29% of the children were sensitized to birch when compared with 2% of the Russian children ( P &lt; 0.0001). Overall, sensitization rates for any of the pollens were 39% and 8% ( P &lt; 0.0001), and for any of the allergens 48% and 16%, respectively ( P &lt; 0.0001). Because of substantial differences in raw water sources and treatment practices, the total numbers of microbial cells in drinking water were many‐fold higher in Russia than in Finland. A dose–response relationship was found for occurrence of atopy and the DAPI value indicative of microbial cell content in the water ( P &lt; 0.0001). Further, multivariate logistic regression analysis revealed that high (&gt;10 6 cells/ml) and intermediate (10 5 –10 6 cells/ml) DAPI values were associated with reduced risk of atopy (odds ratio 0.34, 95% confidence interval 0.20–0.57 and 0.39, 0.23–0.69, respectively), independently from other factors. Conclusion: High overall content of micro‐organisms in drinking water may be associated with reduced risk of atopy, independently from other determinants.
Relational Memory as a Possible Neurocognitive Marker of Schizophrenia
Authors: Martin Lepage, Colin Hawco, Michael Bodnar
Journal: JAMA Psychiatry (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Physical urticaria: classification and diagnostic guidelines
Authors: K. Kontou‐Fili, R. Borici‐Mazi, A. Kapp, L. J. Matjevic, F. B. Mitchel
Journal: Allergy (1997)

Kontou‐Fili K, Borici‐Mazi R, Kapp A, Matjevic LJ, Mitchel FB. Physical urticaria: classification and diagnostic guidelines. An EAACI position paper.
Postmenopausal Osteoporosis
Authors: Dennis M. Black, Clifford J. Rosen
Journal: New England Journal of Medicine (2016)

Key Clinical Points Postmenopausal Osteoporosis Fractures and osteoporosis are common, particularly among older women, and hip fractures can be devastating. Treatment is generally recommended in postmenopausal women who have a bone mineral density T score of -2.5 or less, a history of spine or hip fracture, or a Fracture Risk Assessment Tool (FRAX) score indicating increased fracture risk. Bisphosphonates (generic) and denosumab reduce the risk of hip, nonvertebral, and vertebral fractures; bisphosphonates are commonly used as first-line treatment in women who do not have contraindications. Teriparatide reduces the risk of nonvertebral and vertebral fractures. Osteonecrosis of the jaw and atypical femur fractures have been reported with treatment but are rare. The benefit-to-risk ratio for osteoporosis treatment is strongly positive for most women with osteoporosis. Because benefits are retained after discontinuation of alendronate or zoledronic acid, drug holidays after 5 years of alendronate therapy or 3 years of zoledronic acid therapy may be considered for patients at lower risk for fracture.
Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation
Authors: Sébastien Talbot, Raja-Elie E. Abdulnour, Patrick R. Burkett, Seungkyu Lee, Shane J.F. Cronin, Maud A. Pascal, Cedric Laedermann, Simmie L. Foster, Johnathan V. Tran, Nicole Lai, Isaac M. Chiu, Nader Ghasemlou, Matthew DiBiase, David Roberson, Christian Von Hehn, Busranour Agac, Oliver Haworth, Hiroyuki Seki, Josef M. Penninger, Vijay K. Kuchroo, Bruce P. Bean, Bruce D. Levy, Clifford J. Woolf
Journal: Neuron (2015)
Heredity in Diabetes
Authors: William Allan
Journal: Annals of Internal Medicine (1933)

Article1 April 1933Heredity in DiabetesWILLIAM ALLAN, M.D.WILLIAM ALLAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-10-1272 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe impression prevails that diabetes mellitus is in some degree hereditary. In discussing this matter Joslin1cites the frequency of a history of diabetes in grandparents, parents, uncles, aunts, and children as the group of relatives indicating hereditary tendencies, and the frequency of diabetes in siblings and cousins as indicating familial occurrence of diabetes. In two series of diabetic persons numbering 2,800 and 2,646 he finds the frequency of a history of diabetes in the "hereditary group" to be 15 per cent and 17 per cent respectively. His figures for the familial occurrence of diabetes in his two series are...References1 JOSLIN EP: Treatment of diabetes mellitus, 1928, Lea & Febiger, Philadelphia, p. 142. Google Scholar2 ALLAN W: Inheritance of migraine, Arch. Int. Med., 1928, xlii, 590-599. CrossrefGoogle Scholar3 WRIGHT IS: Hereditary and familial diabetes mellitus, Am. Jr. Med. Sci., 1931, clxxxii, 484-497. CrossrefGoogle Scholar4 HOWARDCAMMIDGE HAPJ: Hyperglycemia as a Mendelian recessive character in mice, Jr. Genet., 1926, xvi, 387-392. Google Scholar5 CAMMIDGE PJ: Diabetes mellitus and heredity, Brit. Med. Jr., 1928, ii, 738-741. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Charlotte, North Carolina*Accepted for publication June 14, 1932. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Rise and Fall of ThriftGenetic patterns in diabetes mellitusClinical studies of the inheritance of diabetes mellitusThe Genetics of Diabetes MellitusType I diabetes mellitusDiabetes Mellitus — A Geneticist’s NightmareThe Genetics of Diabetes Mellitus — A Review of Family DataGenetische Aspekte des Diabetes mellitusThe genetics of diabetesL'ereditarietà del diabete mellitoGenetics of Diabetes mellitusGENETIC PERSPECTIVES IN DIABETES MELLITUSIl problema dell'eredita' del diabeteTHE GENETICS OF DIABETES: A REVIEW*THE FAMILIAL OCCURRENCE OF HYPERTENSION AND CORONARY ARTERY DISEASE, WITH OBSERVATIONS CONCERNING OBESITY AND DIABETES*†CAROLINE BEDELL THOMAS, F.A.C.P., BERNICE HIRSCHHORN COHENHeredity and diabetes 1 April 1933Volume 6, Issue 10Page: 1272-1274KeywordsChildrenDiabetes mellitusHeredity Issue Published: 1 April 1933 PDF downloadLoading ...
Severity of psychiatric symptoms after HIV testing
Authors: S Perry, L Jacobsberg, C A Card, T Ashman, A Frances, B Fishman
Journal: American Journal of Psychiatry (1993)

The authors were interested in the psychiatric effects of serological testing for HIV and what information feasibly available at intake might predict more severe psychiatric symptoms 1 year later.HIV testing in a private office setting was offered to adults at perceived risk for HIV infection but without AIDS. At entry, then 6 and 12 months later, subjects were counseled by psychiatric nurses and assessed by the Hamilton Rating Scale for Depression, Beck Depression Inventory, Spielberger State-Trait Anxiety Inventory, and Brief Symptom Inventory.Mean scores on all measures of psychiatric symptoms were lower at follow-up among both 106 HIV-positive and 222 HIV-negative adults. One year after HIV testing, 121 (37%) of the 328 subjects had scores associated with psychopathology. These elevated scores were not predicted by serostatus but by initial psychopathological scores (N = 150), annual income less than +15,000 (N = 114), being female (N = 46), and history of injection drug use (N = 32) and heterosexual risk factors (N = 60) as compared to males having sex with males (N = 236).Before the development of more severe physical symptoms, on average, knowledge of HIV infection does not increase psychiatric morbidity; however, regardless of serostatus, a notable percentage of at-risk adults have sustained high levels of psychiatric symptoms. Counseling during the HIV testing process provides an opportunity to identify these individuals for closer study and indicated psychiatric treatment.
Predicting ovarian cancer among patients with pelvic mass by SELDI multiplexed biomarker assay
Authors: Eric T. Fung
Journal: Clinical Cancer Research (2006)

A43   Introduction: A panel of seven biomarkers in serum (ITIH4 fragments, transthyretin (TTR), ApoA1, CTAPIII, hepcidin, transferrin, and beta 2-microglobulin (b2M)) has been reported previously (SGO 2006) to improve the positive predictive value for distinguishing benign from malignant ovarian cancer tumors. We have developed a semi-automated SELDI multiplexed assay intended for the analysis of those biomarkers.Description: The multiplexed assay strategy was developed based on the biomarker proteins surface properties and their molecular weights. TTR was assayed on strong anionic (Q10) ProteinChip™ arrays and ApoA1 was assayed on hydrophobic (H50) ProteinChip™ arrays. Specific ITIH4 fragments, CTAPIII, hepcidin, b2M and transferrin were assayed simultaneously on immobilized copper affinity capture (IMAC50) ProteinChip™ arrays. Assay protocol was highly simplified and automated on a Tecan Aquarius robot equipped with a 96-channel pipetting head. High throughput ProteinChip™ arrays readout as well as data handling was performed on a PCS4000 automated mass reader equipped with server data management software (Ciphergen Biosystems). In certain assays, patient serum was diluted in buffer containing  E. coli  lysate as a carrier and internal quantitation standards. Calibration curves of TTR, Apo A1 and ITIH4 fragment were constructed using pooled human serum containing known concentrations of each analyte. Patient samples were assayed in triplicate and CV% was
ORIENTATION OF TREATMENT IN THROMBOPHLEBITIS, PHLEBOTHROMBOSIS AND PULMONARY EMBOLISM
Authors: James A. Evans
Journal: Annals of Internal Medicine (1942)

Article1 December 1942ORIENTATION OF TREATMENT IN THROMBOPHLEBITIS, PHLEBOTHROMBOSIS AND PULMONARY EMBOLISMJAMES A. EVANS, M.D., F.A.C.P.JAMES A. EVANS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-17-6-970 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe treatment of venous thrombosis is very much a method of "damned if you do, damned if you don't." One is never quite sure which case may develop a fatal pulmonary embolism. Out of the welter of confusion on this subject, however, are evolving certain principles which seem reasonable but which may need revision in the future.In the first place, there are now four new well accepted therapeutic procedures, venous ligation and section, paralumbar sympathetic procaine block, anticoagulant therapy and sulfonamide drugs. I shall attempt to point out in what type of venous thrombosis each method seems most applicable.... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Read at the St. Paul meeting of the American College of Physicians April 24, 1942. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnticoagulant Treatment of Postoperative Venous Thrombosis and Pulmonary EmbolismPhlebothrombosis and thrombophlebitis in gynecology and obstetrics 1 December 1942Volume 17, Issue 6Page: 970-974KeywordsAnticoagulant therapyAnticoagulantsDrug therapyForecastingLigation assayPulmonary embolismSulfonamideThrombosis ePublished: 1 December 2008 Issue Published: 1 December 1942 PDF downloadLoading ...
39. Reversal of Diabetes by Inducing Islet Neogenesis Using Helper Dependent Adenovirus Mediated Gene Therapy
Authors: Vijay Yechoor, Hideto Kojima, Mineko Fujimiya, Bonne Thompson, Benny Chang, Laura Nelly, Philip Ng, Lawrence Chan
Journal: Molecular Therapy (2004)

Type 1 diabetes is characterized by insulin deficiency. Islet replacement strategies accord the most physiological therapy for diabetes. However, islet and pancreatic transplantation are limited by donor availability & the need for life-long immunosupression. To overcome these problems, we have adopted gene therapy with islet developmental factors as a means to induce ectopic islet neogenesis. We have shown earlier that therapy with by helper dependent adenoviral (HDAd) mediated gene transfer of Beta2/NeuroD (ND), an islet development factor, in combination with betacellulin (Btc), an islet growth factor, effectively reverses diabetes in chemically (streptozotocin-STZ) induced diabetes by inducing insulin positive cells in the liver (Kojima et. al. Nat medicine 2003). To study this further, we utilized the NOD mouse, a model of autoimmune diabetes. We followed 12 diabetic NOD mice and treated 8 of them with HDAd-ND along with HDAd-Btc. 4 (50%) of the treated mice responded by normalizing their blood sugars within 5 weeks after therapy and gained body weight. At 7 weeks post-therapy, immunohistochemistry of the liver demonstrated the presence of proinsulin in the subcapsular areas of the liver with surrounding lymphocytes indicating an immune reaction. The last of the responder mice remained normoglycemic up to 25 weeks post-therapy. An IP-GTT of the treated mice revealed normal glucose tolerance.
Association of Virus with Cases of Rubella Studied in Toronto: Propagation of the Agent and Transmission to Monkeys
Authors: B SIGURDARDOTTIR, K F GIVAN, K R ROZEE, A J RHODES
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A synopsis of the WPA Educational Program on Personality Disorders
Authors: ERIK SIMONSEN, ELSA RONNINGSTAM, THEODORE MILLON
Journal: World Psychiatry (2008)

This article describes the headlines of the Educational Program on Personality Disorders produced by the WPA Section on Personality Disorders and the International Society on the Study of Personality Disorders. Lifelong personality traits serve as a substrate and a context for understanding more florid and distinct forms of psychopathology. Personality disorders affect at least 10% of the population, and the direct and indirect social costs associated with crime, substance abuse, increased need for medical care, family disruption, delayed recovery from clinical syndromes and medical diseases is substantial. Numerous theories, models and methods have been proposed to describe and to understand personality and its disorders: descriptive, statistical, psychoanalytic, evolutionary, neurobiologic. Classification has either taken a prototypical or a polythetic approach, but in recent years dimensional formats for classifying personalities have gained more interest. Personality pathology has a complex and variable character of interwoven developmental bio-psycho-social influences. A number of reliable instruments for assessment of personality and its disorders have emerged during the last three decades and a wide range of tailored psychotherapeutic techniques are now available. Personality disorders are treatable and remission is more likely than treatment resistance. Education is needed for all health professionals in psychiatric services. The full WPA program is available to be downloaded for free from WPA's website www.wpanet.org.