tbuckley/cabot-search huggingface dataset:
European Cases of Fibrolamellar Hepatocellular Carcinoma
Authors: A. Bassa Malondra
Journal: Annals of Internal Medicine (1989)

Letters and Corrections15 February 1989European Cases of Fibrolamellar Hepatocellular CarcinomaA. Bassa Malondra, MD, PhD, M. Fiol Picornell, MD, J. Terrasa Pons, MD, J.J. Torres Rovira, MD, J. Buades Reines, MD, PhDA. Bassa Malondra, MD, PhDSearch for more papers by this author, M. Fiol Picornell, MDSearch for more papers by this author, J. Terrasa Pons, MDSearch for more papers by this author, J.J. Torres Rovira, MDSearch for more papers by this author, J. Buades Reines, MD, PhDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-110-4-324 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We are writing in response to the letter (1) on fibrolamellar hepatocellular carcinoma, in which Ruffin points out that the cases of this tumor reported since 1941 have all originated in the United States. We report two cases of this tumor diagnosed in patients treated at our hospital.A 25-year-old man was hospitalized for epigastric discomfort; anorexia was present for 5 months. Physical examination showed a liver edge 12 cm below the right costal margin. The erythrocyte sedimentation rate was 135 mm/h; alkaline phosphatase, 100 U/L (normal, ≤ 40 U/L); and gamma-glutamyltransferase, 89 IU/L (normal, ≤ 30...References1. Ruffin M. Fibrolamellar hepatocellular carcinoma [Letter]. Ann Intern Med. 1988;109:596-7. LinkGoogle Scholar2. GraigPetersEdmondsonOmata JRHM. Fibrolamellar carcinoma of the liver: a tumour of adolescents and young adults with distinctive clinicopathologic features. Cancer. 1980;46:372-9. CrossrefMedlineGoogle Scholar3. CaballeroAneirosLopez-CaballeroGomez MoralesNogales TJJMF. Fibrolamellar hepatocellular carcinoma: an immunohistochemical and ultrastructural study. Histopathology. 1985;9:445-56. CrossrefMedlineGoogle Scholar4. Guix PericásSancho PochPladellorens RocaEnriquez ParadelaTrías Rubiés MFMJR. Hepatocarcinoma fibrolamelar: presentacion de dos casos. Gastroenterol Hepatol. 1983;6:475-9. Google Scholar5. VecchioFabianoGhirlandaMannaMassi FAGRG. Fibrolamellar carcinoma of the liver: the malignant counterpart of focal nodular hyperplasia with oncocytic change. Am J Clin Pathol 1984;81:521-6. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Hospital Son Dureta 07002 Palma de Mallorca, Baleares, Spain PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByFibrolamellar hepatocellular carcinoma in Mexican patients 15 February 1989Volume 110, Issue 4Page: 324-324KeywordsErythrocyte sedimentation rateHepatocellular carcinomaLiverPhosphatases Issue Published: 15 February 1989 PDF DownloadLoading ...
Short QT syndrome
Authors: R SCHIMPF, C WOLPERT, F GAITA, C GIUSTETTO, M BORGGREFE
Journal: Cardiovascular Research (2005)

The short QT syndrome constitutes a new clinical entity that is associated with a high incidence of sudden cardiac death, syncope, and/or atrial fibrillation even in young patients and newborns. Patients with this congenital electrical abnormality are characterized by rate-corrected QT intervals<320 ms. Missense mutations in KCNH2 (HERG) linked to a gain-of-function of the rapidly activating delayed-rectifier current IKr have been identified in the first two reported families with familial sudden cardiac death. Recently, two further gain-of-function mutations in the KCNQ1 gene encoding the α-subunit of the KvLQT1 (IKs) channel and in the KCNJ2 gene encoding the strong inwardly rectifying channel protein Kir2.1 confirmed a genetically heterogeneous disease. The possible substrate for the development of ventricular tachyarrhythmias may be a significant transmural dispersion of the repolarisation due to a heterogeneous abbreviation of the action potential duration. The implantable cardioverter defibrillator is the therapy of choice in patients with syncope and a positive family history of sudden cardiac death. However, ICD therapy in patients with a short QT syndrome has an increased risk for inappropriate shock therapies due to possible T wave oversensing. The impact of sotalol, ibutilide, flecainide, and quinidine on QT prolongation has been evaluated, but only quinidine effectively suppressed gain-of-function in IKr with prolongation of the QT interval. In patients with a mutation in HERG, it rendered ventricular tachycardias/ventricular fibrillation non-inducible and restored the QT interval/heart rate relationship towards a normal range. It may serve as an adjunct to ICD therapy or as a possible alternative treatment, especially for children and newborns.
Use of oral corticosteroids in the community and the prevention of secondary osteoporosis: a cross sectional study
Authors: L J Walsh, C A Wong, M Pringle, A E Tattersfield
Journal: BMJ (1996)

<h3>Abstract</h3> <b>Objective</b>: To determine the prevalence of continuous use of oral steroids in the general population, the conditions for which they are prescribed, and the extent to which patients taking oral steroids are taking treatment to prevent osteoporosis. <b>Design</b>: A cross sectional study with a four year retrospective review of drug treatment. <b>Setting</b>: Eight large general practices in central and southern Nottinghamshire. <b>Subjects</b>: A population of 65 786 patients (52% women) registered with a general practitioner during 1995. <b>Results</b>: 303 patients (65% (197) women) aged 12-94 years were currently taking "continuous" (for at least three months) oral corticosteroid treatment. This figure represents 0.5% of the total population and 1.4% (245/17 114) of patients aged 55 years or more (1.7% (166/9601) of women). The usual steroid was prednisolone (97% (294/303)), the mean dose was 8.0 mg/day, and the median duration of oral steroid treatment determined in 149 patients was three years. The most common conditions for which continuous oral steroids were prescribed were rheumatoid arthritis (23% (70)), polymyalgia rheumatica (22% (66)), and asthma or chronic obstructive airways disease (19% (59)). Only 41 (14%) of the 303 patients taking oral steroids had received treatment for the prevention of osteoporosis over the past four years. Although 37 of the 41 patients were women, only 10% (18/181) of the women over 45 years taking continuous oral corticosteroids were currently taking hormone replacement therapy. <b>Conclusions</b>: If our figures are typical then they suggest that over 250 000 people in the United Kingdom are taking continuous oral steroids and that most of these are taking no prophylaxis against osteoporosis. <h3>Key messages</h3> The prevalence of use of oral corticosteroids in a community based population of 65 786 was 0.5%, rising to 1.7% in women aged &gt;/=55 years The main indications for oral steroids were rheumatoid arthritis, polymyalgia, and asthma or chronic obstructive pulmonary disease Only 14% of patients taking oral steroids had received any treatment to prevent or treat osteoporosis These data suggest that over a quarter of a million people in the United Kingdom are currently taking oral corticosteroids and hence at risk of adverse effects
A critical review of the systolic time intervals.
Authors: R P Lewis, S E Rittogers, W F Froester, H Boudoulas
Journal: Circulation (1977)

The theoretical basis for the use of the systolic time intervals has been largely established. The method has been validated by direct measures from within the circulatory system. Standards for equipment and technique have been defined. Numerous clinical studies have demonstrated the value of this quantitative noninvasive technique for assessing left ventricular performance. At present there is need for further studies of the clinical usefulness of the systolic time intervals to improve both diagnosis and therapy of various cardiovascular disorders.
The cerebral cortex: a case for a common site of action of antipsychotics
Authors: M.S. Lidow, G.V. Williams, P.S. Goldman-Rakic
Journal: Trends in Pharmacological Sciences (1998)

Recent evidence from studies of receptor occupancy and regulation in post-mortem brains of patients with neuropsychiatric disorders and in non-human primates is providing new leads in the ongoing quest to understand the pathophysiology and causes of schizophrenia and to develop more effective methods of treatment. These studies suggest that the cerebral cortex may harbour the elusive common sites of action of antipsychotic medications and indicate that chronic treatment with these drugs differentially regulates both families of dopamine receptors in this structure. Upregulation of the cortical dopamine D2 receptors is accompanied by a downregulation of the D1 sites. Balancing the opposing actions of dopamine D1 and D2 receptor regulation may hold the key to optimal drug therapy and to understanding the pathophysiology of schizophrenia. In this article, Michael Lidow, Graham Williams and Patricia Goldman-Rakic review the evidence supporting the cerebral cortex as a pivotal site for these mechanisms underlying the action of antipsychotics.
Early Coenzyme Q10 Supplementation in Primary Coenzyme Q10 Deficiency
Authors: Giovanni Montini, Cristina Malaventura, Leonardo Salviati
Journal: New England Journal of Medicine (2008)

To the Editor: Primary coenzyme Q10 deficiency is considered to be the only treatable mitochondrial disorder, since patients have a response to oral coenzyme Q10 supplementation. The disease usually manifests with nephropathy and encephalomyopathy.1 It has been shown that oral coenzyme Q10 may stop the progression of encephalopathy, but no benefit from this therapy has been noted with respect to the evolution of renal disease associated with this deficiency.1,2 We now describe the results of long-term coenzyme Q10 supplementation in two patients with coenzyme Q10 deficiency caused by a homozygous missense mutation in the COQ2 gene.3,4 The clinical . . .
Lixivaptan for Hyponatremia—The Numbers Game
Authors: Ryan T. Borne, Mori J. Krantz
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anticardiolipin antibodies in systemic lupus erythematous.
Authors: N Snowden, P Wilson, R Pumphrey
Journal: Annals of the Rheumatic Diseases (1989)

Antibodies to HTLV-I in sera from patients with connective tissue diseases SIR, It has been suggested that HTLV-I infection may be associated with the development of some connective tissue diseases (CTD), including poly-and dermatomyositis (PM and DM), systemic lupus erythematosus (SLE), scleroder- ma, and Sjogrens syndrome (SS).' 2 This was based on
Paint and Grease Gun Injuries of the Hand
Authors: Ronald J. Mann
Journal: JAMA (1975)

PENETRATING high-velocity injection wounds of the hand caused by grease and paint are common. They are surgical emergencies and require immediate decompression. To treat these wounds by expectant observation can cause catastrophic results with eventual amputation of digits. A review of the literature shows 73 pressure gun injuries of the hand.<sup>1-3</sup>There were 30 grease gun injuries of which 12 resulted in amputation. There were 23 paint gun injuries of which ten required amputation. The nozzles of paint and grease guns emit a fine jet stream from 600 to 7,000 pounds per square inch.<sup>4</sup>This is like the muzzle velocity of a rifle. Paint or grease fired at these velocities through small nozzles drives the jet stream through the skin and then it spreads along fascial planes, tendon sheaths, and even neurovascular bundles. After entering the finger, the paint or grease may be found in the palm, wrist,
Treatment of brittle nails and dry eyes
Authors: A.J. Campbell, G.C. McEwan
Journal: British Journal of Dermatology (1981)

Journal Article Treatment of brittle nails and dry eyes Get access A.J. Campbell, A.J. Campbell Hairmyres Hospital, East Kilbride G75 8RG Gartnavel General Hospital, Glasgow Search for other works by this author on: Oxford Academic Google Scholar G.C. McEwan G.C. McEwan Hairmyres Hospital, East Kilbride G75 8RG Gartnavel General Hospital, Glasgow Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 105, Issue 1, 1 July 1981, Page 113, https://doi.org/10.1111/j.1365-2133.1981.tb00893.x Published: 01 July 1981
An elderly woman with postprandial abdominal pain
Authors: A. Ramasamy, R. Sunthareswaran, D. Warakaulle, S. Dubrey
Journal: BMJ (2014)

An 84 year old woman presented with a five month history of central, recurrent, severe epigastric pain, which occurred about 20 minutes after eating. This was associated with nausea, occasional diarrhoea, and vomiting. She had experienced early satiety and weight loss over the last few months. Her medical history included myocardial infarction two years earlier. She also had a 40 pack year history of smoking. On examination, she was cachectic, but physical examination and digital rectal examination were otherwise unremarkable. Blood tests—including full blood count, liver functions tests, amylase, and renal function—were normal. Chest and abdominal radiographs, abdominal ultrasound, and computed tomography of the abdomen were unremarkable. Computed tomography angiography was performed (fig 1⇓).





### 1. What does the computed tomography angiogram show?

#### Short answer

Stenotic disease of the proximal segments of the coeliac axis and superior mesenteric artery.

#### Long answer

The computed tomography …
SPINAL DEFORMITY AS CAUSE OF CARDIAC HYPERTROPHY
Authors: William D. Reid
Journal: JAMA (1930)

Finley<sup>1</sup>reported four cases of extreme deformity of the thorax resulting in hypertrophy and dilatation of the heart with cardiac insufficiency. Another observer<sup>2</sup>reports the reverse of this sequence in a girl, aged 14, who acquired rheumatic mitral stenosis at the age of 3 and in whom increasing deformity of the spine appeared at the age of 10 years. I reported a possible case of the sequence pointed out by Finley, in the first edition of my book.<sup>3</sup> The case now reported here is, perhaps, more convincing: <h3>REPORT OF CASE</h3><h3>History.</h3> —A girl, aged 16, was admitted to the hospital, May 10, 1928, in an orthopneic, markedly cyanosed condition, with edema of the legs, lower abdominal wall and face. There had been dyspnea on moderate exertion during the past few months, and occasional attacks of palpitation in the last three or four years. Two weeks before entrance
Insensitivity of the analysis of variance to heredity-environment interaction
Authors: Douglas Wahlsten
Journal: Behavioral and Brain Sciences (1990)

Abstract It makes sense to attribute a definite percentage of variation in some measure of behavior to variation in heredity only if the effects of heredity and environment are truly additive. Additivity is often tested by examining the interaction effect in a two-way analysis of variance (ANOVA) or its equivalent multiple regression model. If this effect is not statistically significant at the α = 0.05 level, it is common practice in certain fields (e.g., human behavior genetics) to conclude that the two factors really are additive and then to use linear models, which assume additivity. Comparing several simple models of nonadditive, interactive relationships between heredity and environment, however, reveals that ANOVA often fails to detect nonadditivity because it has much less power in tests of interaction than in tests of main effects. Likewise, the sample sizes needed to detect real interactions are substantially greater than those needed to detect main effects. Data transformations that reduce interaction effects also change drastically the properties ofthe causal model and may conceal theoretically interesting and practically useful relationships. If the goal ofpartitioning variance among mutually exclusive causes and calculating “heritability” coefficients is abandoned, interactive relationships can be examined more seriously and can enhance our understanding of the ways living things develop.
Miscuffing: inappropriate blood pressure cuff application.
Authors: D M Manning, C Kuchirka, J Kaminski
Journal: Circulation (1983)

For the accurate indirect measurement of blood pressure (BP), the American Heart Association (AHA) now recommends that cuff size should be based solely on limb circumference. We studied prevailing cuffing habits and compared them with newly revised AHA guidelines. Monitoring our staff's cuff applications, we found that "miscuffing" occurred in 65 (32%) of 200 BP determinations on 167 unselected adult outpatients, including 61 (72%) of 85 readings taken on "nonstandard" size arms. Undercuffing large arms was the most frequent error, accounting for 84% of the miscuffings. Considering that miscuffing distorts BP readings by an average of 8.5 mm Hg systolic and 4.6 mm Hg diastolic, we can improve the accuracy of our BP determinations by remarking our cuffs and using the new AHA guidelines.
Statins and congenital malformations: cohort study
Authors: B. T. Bateman, S. Hernandez-Diaz, M. A. Fischer, E. W. Seely, J. L. Ecker, J. M. Franklin, R. J. Desai, C. Allen-Coleman, H. Mogun, J. Avorn, K. F. Huybrechts
Journal: BMJ (2015)

<b>Objective</b> To examine the teratogenic potential of statins. <b>Design</b> Cohort study. <b>Setting</b> United States. <b>Participants</b> A cohort of 886 996 completed pregnancies linked to liveborn infants of women enrolled in Medicaid from 2000 to 2007. <b>Methods</b> We examined the risk of major congenital malformations and organ specific malformations in offspring associated with maternal use of a statin in the first trimester. Propensity score based methods were used to control for potential confounders, including maternal demographic characteristics, obstetric and medical conditions, and use of other drugs. <b>Results</b> 1152 (0.13%) women used a statin during the first trimester. In unadjusted analyses, the prevalence of malformations in the offspring of these women was 6.34% compared with 3.55% in those of women who did not use a statin in the first trimester (relative risk 1.79, 95% confidence interval 1.43 to 2.23). Controlling for confounders, particularly pre-existing diabetes, accounted for this increase in risk (1.07, 0.85 to 1.37). There were also no statistically significant increases in any of the organ specific malformations assessed after accounting for confounders. Results were similar across a range of sensitivity analyses. <b>Conclusions</b> Our analysis did not find a significant teratogenic effect from maternal use of statins in the first trimester. However, these findings need to be replicated in other large studies, and the long term effects of in utero exposure to statins needs to be assessed, before use of statins in pregnancy can be considered safe.
Clopidogrel-induced acute generalized exanthematous pustulosis with elevated Th17 cytokine levels as determined by a drug lymphocyte stimulation test
Authors: S. Nakamizo, S. Kobayashi, T. Usui, Y. Miyachi, K. Kabashima
Journal: British Journal of Dermatology (2010)

Journal Article Clopidogrel‐induced acute generalized exanthematous pustulosis with elevated Th17 cytokine levels as determined by a drug lymphocyte stimulation test Get access S. Nakamizo, S. Nakamizo Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar S. Kobayashi, S. Kobayashi Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, 54 Shogoin‐Kawara, Sakyo, Kyoto 606‐8507, Japan E‐mail: s.nakami@kuhp.kyoto‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar T. Usui, T. Usui Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, 54 Shogoin‐Kawara, Sakyo, Kyoto 606‐8507, Japan E‐mail: s.nakami@kuhp.kyoto‐u.ac.jp Search for other works by this author on: Oxford Academic Google Scholar Y. Miyachi, Y. Miyachi Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar K. Kabashima K. Kabashima Departments of Dermatology Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 162, Issue 6, 1 June 2010, Pages 1402–1403, https://doi.org/10.1111/j.1365-2133.2010.09705.x Published: 01 June 2010
Treatment of lupus nephritis in adult (NZB + NZW)F1 mice by cortisone-facilitated tolerance to nucleic acid antigens.
Authors: Y Borel, R M Lewis, J André-Schwartz, B D Stollar, E Diener
Journal: Journal of Clinical Investigation (1978)

Adult female (NZB + NZW)F1 mice were treated with cortisone, cortisone with tolerogen (isologous NZB IgG-nucleosides conjugates) or cortisone with isologous IgG free of nucleosides. Other treatments also included tolerogen or isologous IgG alone, and cortisone together with denatured DNA. All untreated mice died by 10 mo of age. Cortisone prolonged the survival rate. This effect was further improved by combined treatment of cortisone and tolerogen. Prolonged survival was accompanied by a decrease in proteinuria. Other treatments failed to influence either survival or proteinuria. Although cortisone did not prevent the appearance of antibody to denatured DNA, cortisone and tolerogen suppressed them in most of the animals. Preexisting antibody to denatured DNA was reduced by cortisone and cortisone and tolerogen, but not by cortisone and IgG. In contrast, antibody to native DNA bore no relationship to therapy. Animals living beyond 1 yr of age, regardless of the treatment, fall into three histopathological categories: (a) severe nephritis, as in untreated animals, (b) moderate nephritis (with absence of severe alteration of the glomerular basement membrane, i.e. the histological counterpart of prolonged survival), (c) minimal nephritis. In a small number of animals treated with cortisone or cortisone and IgG and in 6/20 animals treated with cortisone and tolerogen, minimal lesions as judged by light, fluorescent, and electron microscopy were found. These last mice were in good health at 15-16 mo of age, twice the life-span of untreated mice. In conclusion, these data suggest that tolerance to nucleic acid antigens facilitated by cortisone offers a promising new approach to treat established murine lupus nephritis.