Intradermal Tests and Antinuclear Factors in Systemic Lupus Erythematosus
Authors: FARIS J. AZOURY
Journal: Annals of Internal Medicine (1966)

Article1 December 1966Intradermal Tests and Antinuclear Factors in Systemic Lupus ErythematosusA Comparative StudyFARIS J. AZOURY, M.D., HENRY E. JONES, M.D., VINCENT J. DERBES, M.D., F.A.C.P., OREN B. GUM, M.D., PH.D.FARIS J. AZOURY, M.D.Search for more papers by this author, HENRY E. JONES, M.D.Search for more papers by this author, VINCENT J. DERBES, M.D., F.A.C.P.Search for more papers by this author, OREN B. GUM, M.D., PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-65-6-1221 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAbnormal immunological reactions have been described more frequently and in greater number in systemic lupus erythematosus (SLE) than in any other disease. A wide variety of circulating antibodies that are capable of reacting with the patient's own tissues has been identified. Among these antibodies is a group that reacts with various nuclear components. Through the wide use of the immunofluorescent technique, the antinuclear factors (ANF) have been studied extensively by many investigators. However, to date very little has been done to correlate the presence of humoral antinuclear immunoglobulins and skin reactivity to nuclear antigens in SLE.Skin lesions are commonly...References1. DUBOISTUFFANELLI ELDL: Clinical manifestations of systemic lupus erythematosus. Computer analysis of 520 cases. JAMA 190: 104, 1964. CrossrefMedlineGoogle Scholar2. WATSONO'LEARYHARGRAVES JBPAMM: Neutrophils resembling LE cells in artificial blisters. Arch. Derm. (Chicago) 63: 328, 1951. CrossrefGoogle Scholar3. REBUCKBERMAN JWL: Experimental production of the LE phenomenon in the skin of man. Proc. Soc. Exp. Biol. Med. 75: 259, 1950. CrossrefMedlineGoogle Scholar4. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FARIS J. AZOURY, M.D.; HENRY E. JONES, M.D.; VINCENT J. DERBES, M.D., F.A.C.P.; OREN B. GUM, M.D., PH.D.Affiliations: New Orleans, Louisiana, and Detroit, MichiganFrom the Section of Arthritis, Department of Medicine, Section of Allergy and Dermatology, Department of Medicine, Tulane University School of Medicine, New Orleans, La., and the Section of Rheumatology, Department of Medicine, Wayne State University School of Medicine, Detroit, Mich.This work was supported in part by grant TI AM 5005, the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Md.This paper was presented in part at the Annual Meeting of the American Rheumatism Association, June 17, 1965, Philadelphia, Pa.Requests for reprints should be addressed to Faris J. Azoury, M.D., Department of Medicine, Wayne State University School of Medicine, 1400 Chrysler Freeway, Detroit, Mich. 48207. 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