LÖFFLER'S SYNDROME: REPORT OF A CASE ASSOCIATED WITH ADMINISTRATION OF MEPHENESIN CARBAMATE (TOLSERAM)
Authors: T RODMAN, W FRAIMOW, R M MYERSON
Journal: Annals of Internal Medicine (1958)

Case Reports1 March 1958LÖFFLER'S SYNDROME: REPORT OF A CASE ASSOCIATED WITH ADMINISTRATION OF MEPHENESIN CARBAMATE (TOLSERAM)THEODORE RODMAN, M.D., WILLIAM FRAIMOW, M.D., RALPH M. MYERSON, M.D., F.A.C.P.THEODORE RODMAN, M.D.Search for more papers by this author, WILLIAM FRAIMOW, M.D.Search for more papers by this author, RALPH M. MYERSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-3-668 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1932 and 1936 Löffler1, 2described a syndrome, commonly associated with his name, characterized by transitory pulmonary infiltrations that are often migratory, eosinophilia, and a benign course with few symptoms. Since then experimental, clinical and pathologic evidence has been accumulated which supports the allergic nature of this syndrome. A wide variety of agents have been incriminated as allergens. Many reports describe Löffler's syndrome secondary to various helminthic infestations. Less frequently, cases have been reported in association with amebiasis,3brucellosis,4coccidioidomycosis,5and following exposure to ragweed and privet pollen.6The administration of drugs such as Prontosil,7sulfonamides,8, 9penicillin10, 11...Bibliography1. Löffler W: Zur Differential-Diagnose der Lungeninfiltrierungen; über flüchtige Succedan-Infiltrate (mit Eosinophilie), Beitr. z. Klin. Tuberk. 79: 368-382, 1932. CrossrefGoogle Scholar2. Löffler W: Die fluchtigen Lungeninfiltrate mit Eosinophilie, Schweiz. med. Wchnschr. 66: 1069-1078, 1936. Google Scholar3. HoffHicks AHM: Transient pulmonary infiltrations; case with eosinophilia (Löffler's syndrome) associated with amoebiasis, Am. Rev. Tuberc. 45: 194-199, 1942. Google Scholar4. ElsomIngelfinger KAFJ: Eosinophilia and pneumonitis in chronic brucellosis; report of 2 cases, Ann. Int. Med. 16: 995-1002, 1942. LinkGoogle Scholar5. WillettOppenheim FME: Pulmonary infiltrations with associated eosinophilia, Am. J. M. Sc. 212: 608-612, 1946. CrossrefMedlineGoogle Scholar6. Engel D: Über eine eigenartige, anaphylaktische Erkrankung der Lunge, Beitr. z. Klin. Tuberk. 87: 239-250, 1935. CrossrefGoogle Scholar7. EllisMcKinlay RVCA: Allergic pneumonia, J. Lab. and Clin. Med. 26: 1427-1432, 1941. Google Scholar8. Contratto AW: So-called "atypical pneumonia" among college students, New England J. Med. 229: 229-235, 1943. CrossrefGoogle Scholar9. Klinghoffer JF: Löffler's syndrome following use of a vaginal cream, Ann. Int. Med. 40: 343-350, 1954. LinkGoogle Scholar10. FalkNewcomer MSVD: Löffler's syndrome: occurrence in 2 patients treated with penicillin in oil and wax, J. A. M. A. 141: 21-22, 1949. CrossrefMedlineGoogle Scholar11. ReichlinLovelessKane SMHEG: Löffler's syndrome following penicillin therapy, Ann. Int. Med. 38: 113-120, 1953. LinkGoogle Scholar12. Tuchman H: Löffler's reaction to para-aminosalicylic acid, Am. Rev. Tuberc. 70: 171-175, 1954. MedlineGoogle Scholar13. Cuthbert RJ: Löffler's syndrome occurring during streptomycin and P. A. S. therapy, Brit. M. J. 2: 398-399, 1954. CrossrefMedlineGoogle Scholar14. ThomasPoutsiakaKuleszaLinegar BGJWJSCR: Toxicity and blood level studies on 3-(o-toloxy)-2 hydroxypropyl carbamate (Tolserol carbamate), J. Pharmacol. and Exper. Therap. 110: 48, 1954. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication July 16, 1956.From the Medical Service, Veterans Administration Hospital, Philadelphia, Pennsylvania.Requests for reprints should be addressed to Ralph M. Myerson, M.D., Assistant Chief, Medical Service, Veterans Administration Hospital, University and Woodland Avenues, Philadelphia 4, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byACTION THROUGH CHANNELS OTHER THAN AIRBORNEDrug-induced eosinophilic lung diseaseDrug-Induced Hypersensitivity Reactions in the LungIatrogene und exogen bedingte LungenerkrankungenEosinophile LungenkrankheitenThe Spectrum of Drug-Induced Pulmonary DiseaseE. C. ROSENOW III, M.D., F.A.C.P.Drug-induced lung diseasePulmonary Infiltrations with Eosinophilia as a Manifestation of CarcinomaRadiological manifestations of drug-induced diseaseAllergic Pulmonary Complications During Treatment with NitrofurantoinAscaris pneumoniaThe Value of Mephenesin Carbamate in the Control of Pain in Patients with Tic DouloureuxPulmonary infiltrates, pericarditis and eosinophiliaRecurrent Pulmonary Infiltration and Pleural Effusion Due to Nitrofurantoin Sensitivity 1 March 1958Volume 48, Issue 3Page: 668-674KeywordsAllergensAmebiasisBrucellosisCoccidioidomycosisDrug administrationDrugsEosinophiliaMedical services ePublished: 1 December 2008 Issue Published: 1 March 1958 PDF downloadLoading ...