ACUTE IDIOPATHIC HEMOLYTIC ANEMIA: REPORT OF A SEVERE FATAL CASE WITH IMMUNOLOGIC OBSERVATIONS
Authors: C G CRADDOCK
Journal: Annals of Internal Medicine (1951)

Case Reports1 October 1951ACUTE IDIOPATHIC HEMOLYTIC ANEMIA: REPORT OF A SEVERE FATAL CASE WITH IMMUNOLOGIC OBSERVATIONSCHARLES G. CRADDOCK JR., M.D.CHARLES G. CRADDOCK JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-4-912 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHemolytic destruction of red blood cells as a result of the activity of circulating agglutinins and hemolysins is often encountered clinically. The antigenic stimulus for the sudden appearance of these abnormal antibodies in various types of transfusion reactions is well understood and their presence is usually demonstrable by in vitro technics. In the case of idiopathic acquired hemolytic anemia, however, the immunologic processes are not understood. The classic work of Dameshek and Schwartz1leaves little doubt that the presence of hemolysins or agglutinins plays an important part in the pathologic destruction of red cells in these cases. Similar findings have...Bibliography1. DameshekSchwartz WSO: Acute hemolytic anemia (acquired hemolytic icterus, acute type), Medicine 19: 231-327, 1940. CrossrefGoogle Scholar2. Wiener AS: A new test (blocking test) for Rh sensitization, Proc. Soc. Exper. Biol. and Med. 56: 173-176, 1944. CrossrefGoogle Scholar3. Race RR: "Incomplete" antibody in human serum, Nature, London 108: 771-772, 1944. CrossrefGoogle Scholar4. CoombsMourantRace RRAERR: In vivo isosensitization of red cells in babies with hemolytic disease, Lancet 1: 264-266, 1946. CrossrefMedlineGoogle Scholar5. BoormanDoddLoutit KEBETF: Hemolytic icterus, congenital and acquired, Lancet 1: 812-814, 1946. CrossrefMedlineGoogle Scholar6. DameshekBloom WML: The events in the hemolytic crisis of hereditary spherocytosis with particular reference to the reticulocytopenia, pancytopenia and an abnormal splenic mechanism, Blood 3: 1381-1410, 1948. CrossrefMedlineGoogle Scholar7. CoburnKapp AFEM: Effect of salicylates on precipitation of antigen with antibody, J. Exper. Med. 77: 173-183, 1943. CrossrefMedlineGoogle Scholar8. Coburn AF: Salicylate therapy in rheumatic fever: rational technic, Bull. Johns Hopkins Hosp. 73: 435-464, 1943. Google Scholar9. Homburger F: Sodium salicylate inhibition of anti-Rh immunization in animals, Proc. Soc. Exper. Biol. and Med. 61: 101-102, 1946. CrossrefMedlineGoogle Scholar10. Dameshek W: Hemolytic mechanisms, Ann. New York Acad. Sc. 48: 685-703, 1947. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Charlottesville, Virginia*Received for publication July 21, 1949.From the Department of Medicine of the University of Virginia Hospital.†Now at Massachusetts General Hospital, Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySerologie und Klinik der autoimmunhämolytischen Erkrankungen 1 October 1951Volume 35, Issue 4Page: 912-918KeywordsAgglutininsAntibodiesAntigensCellsHemolytic anemiaHospital medicineRed blood cells ePublished: 1 December 2008 Issue Published: 1 October 1951 PDF downloadLoading ...