RELAPSING FEBRILE NODULAR NONSUPPURATIVE PANNICULITIS (WEBER-CHRISTIAN DISEASE); REVIEW OF LITERATURE AND REPORT OF CASE
Authors: J D HALLAHAN, T KLEIN
Journal: Annals of Internal Medicine (1951)

Article1 May 1951RELAPSING FEBRILE NODULAR NONSUPPURATIVE PANNICULITIS (WEBER-CHRISTIAN DISEASE); REVIEW OF LITERATURE AND REPORT OF CASEJOHN D. HALLAHAN, M.SC., M.D., THOMAS KLEIN, M.D., F.A.C.P.JOHN D. HALLAHAN, M.SC., M.D.Search for more papers by this author, THOMAS KLEIN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-5-1179 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDEFINITIONRelapsing, febrile, nodular, nonsuppurative panniculitis is a title that defines a disease, which is characterized by recurrent episodes of fever ranging as high as 104° F., and by the formation of single to multiple crops of tender or painless, freely movable, inflammatory and necrotic nodules in the panniculus adiposus. The nodules do not produce pus and may regress in a few days or weeks, either leaving a shallow dimple in the skin or showing no superficial evidence of their site. The nodules range from about 0.5 to 3 cm. in diameter. The overlying skin may be normal in color...Bibliography Other Cases Reported But Not Referred To In This Review1. Pfeiffer V: Uber ein Fall von herdweiser des subcutanen Fettegewebe, Deutsches Arch. f. klin. Med. 50: 438-449, 1892. Google Scholar2. Weber FP: Case of relapsing, nonsuppurative, nodular panniculitis showing phagocytoses of subcutaneous fat cells by macrophages, Brit. J. Dermat. 37: 301-311, 1925. CrossrefGoogle Scholar3. Christian HA: Relapsing, febrile, nodular, nonsuppurative panniculitis, Arch. Int. Med. 42: 338-351, 1928. Or Christian, H. A.: Relapsing, febrile, nodular, nonsuppurative panniculitis, Trans. A. Am. Physicians 43: 266-271, 1928. CrossrefGoogle Scholar4. Weber FP: A further note on relapsing, febrile, nodular, nonsuppurative panniculitis, Brit. J. Dermat. 47: 230-235, 1935. CrossrefGoogle Scholar5. Keil H: Pannicultis: its place in nosology, Brit. J. Dermat. 47: 512-521, 1935. CrossrefGoogle Scholar6. Bailey RJ: Relapsing, febrile, nodular, nonsuppurative panniculitis (Weber-Christian disease), J. A. M. A. 109: 1419-1425, 1937. CrossrefGoogle Scholar7. RosenbergCohen WATM: Relapsing, febrile, nodular, nonsuppurative panniculitis (Weber-Christian disease), Illinois M. J. 81: 59-62, 1942. Google Scholar8. NiedermayerMoran AJTJ: Relapsing, febrile, nodular, nonsuppurative panniculitis: report of case treated with penicillin, Ann. Int. Med. 29: 958-964, 1948. LinkGoogle Scholar9. LarsonOotkin CPBN: Relapsing, febrile, nodular, nonsuppurative panniculitis (Weber-Christian disease); case, Am. J. Clin. Path. 11: 781-787, 1941. CrossrefGoogle Scholar10. Shaffer B: Liquefying nodular panniculitis, Arch. Dermat. and Syph. 38: 535-544, 1938. CrossrefGoogle Scholar11. BunnellLevy ILDS: Weber-Christian's disease: report of a case, Ann. Int. Med. 28: 169-172, 1948. LinkGoogle Scholar12. CumminsLever LJWF: Relapsing, febrile, nodular nonsuppurative panniculitis (Weber-Christian disease), Arch. Dermat. and Syph. 38: 415-426, 1938. CrossrefGoogle Scholar13. Machacek GF: Chronic panniculitis of unknown source (Weber-Christian disease?) (relapsing, febrile, (?) nodular, nonsuppurative panniculitis), Arch. Dermat. and Syph. 40: 473-474, 1939. Google Scholar14. Sweitzer S: Panniculitis, Arch. Dermat. and Syph. 39: 1096, 1939. Google Scholar15. AldersonWay HESC: Relapsing, febrile nonsuppurative panniculitis (Weber), Arch. Dermat. and Syph. 27: 440-449, 1933. CrossrefGoogle Scholar16. PieriniIrigoyenUgazio LELDA: Panniculitis nodular recidivante no suppurativa febrile (Weber-Christian), Pub. Centro tisiol. B. Air. 10: 97-124, 1946. MedlineGoogle Scholar17. LarkinDeSanctisMargulis VdAGAE: Relapsing febrile nodular nonsuppurative panniculitis (Weber-Christian disease); case, Am. J. Dis. Child. 67: 120-125, 1944. CrossrefGoogle Scholar18. BaumgartnerRiva WG: Pannikulitis, die herdförmige Fettgewebsentzündung, Helvet. med. acta 12 (supp. 14): 3-69, 1945. MedlineGoogle Scholar19. Binkley JS: Relapsing, febrile, nodular, nonsuppurative panniculitis, report of a case, J. A. M. A. 113: 113-116, 1939. CrossrefGoogle Scholar20. Skiöld N: Relapsing, febrile, nonsuppurative panniculitis, Acta med. Scandinav. 105: 43-47, 1940. CrossrefGoogle Scholar21. MillerKritzler JLRA: Nodular, nonsuppurative panniculitis, Arch. Dermat. and Syph. 47: 82-96, 1943. CrossrefGoogle Scholar22. MostofiEngleman FKE: Fatal relapsing febrile, nonsuppurative panniculitis, Arch. Path. 43: 417-426, 1947. Google Scholar23. Arnold HL: Nodular nonsuppurative panniculitis (Weber-Christian disease). Preliminary report of a case controlled by sulfapyridine, Arch. Dermat. and Syph. 51: 94-99, 1945. CrossrefGoogle Scholar24. Ives G: Relapsing, febrile, nodular, nonsuppurative panniculitis with report of a case, J. Missouri M. A. 42: 409-410, 1945. MedlineGoogle Scholar25. CarolPrakkenvan Zwijndregt WLJRHA: Erythema nodosum und "relapsing febrile nodular nonsuppurative panniculitis," Arch. f. Dermat. u. Syph. 182: 329-366, 1941. CrossrefGoogle Scholar26. TildenGotshalkAvakian ILHCEV: Relapsing, febrile, nonsuppurative panniculitis, Arch. Dermat. and Syph. 41: 681-689, 1940. CrossrefGoogle Scholar27. SpainFoley DMJM: Report on Weber-Christian disease, Am. J. Path. 20: 783-787, 1944. MedlineGoogle Scholar28. ReedAnderson ACHH: Relapsing, nonsuppurative panniculitis, California and West. Med. 47: 325-327, 1937. MedlineGoogle Scholar29. Fraser JF: Nonsuppurative panniculitis (Weber-Christian), Arch. Dermat. and Syph. 45: 810-811, 1942. Google Scholar30. KosterBehr LE: Une forme spéciale de la lipogranulomatose généralisée, Acta med. Scandinav. 93: 30-41, 1937. CrossrefGoogle Scholar31. Sundwall J: Localized areas of atrophy of fat cells in derma and subcutaneous tissues, J. Cutan. Dis. 36: 145-153, 1918. Google Scholar32. GilchristKetron TCLW: A unique case of atrophy of the fatty layers of the skin, preceded by the ingestion of fat by large phagocytic cells, macrophages, Bull. Johns Hopkins Hosp. 27: 291-294, 1916. Google Scholar33. Zee ML: Nodular, nonsuppurative panniculitis treated with penicillin, J. A. M. A. 130: 1219-1220, 1946. CrossrefMedlineGoogle Scholar34. HazelLamb OGJ: Primary panniculitis (Weber-Christian disease) afebrile in type and associated with sclerodermatous-like changes, J. Oklahoma M. A. 33: 1-5, 1940. Google Scholar35. Brill IC: Relapsing, febrile, nodular, nonsuppurative panniculitis (Weber-Christian disease) in medical papers dedicated to Henry Asbury Christian, physician and teacher, 1936, Waverly Press, Inc., Baltimore, pp. 694-704. Google Scholar36. Kritzler R: A case of Weber-Christian disease, Proc. New York Path. Soc. (abstract), 47, 1941. Google Scholar37. Friedman NB: Fatal panniculitis and autopsy, Arch. Path. 39: 42-46, 1945. Google Scholar38. Baumgartner W: Zur Pathologie des Fettgewebes: Die Panniculitis, Helvet. med. acta 11: 155-159, 1944. Google Scholar39. HansonFowler WALH: Relapsing, febrile, nodular, nonsuppurative panniculitis, Minnesota Med. 24: 779-782, 1941. Google Scholar40. Netherton EW: Relapsing, febrile, nodular, nonsuppurative panniculitis, Arch. Dermat. and Syph. 28: 258-259, 1933. Google Scholar41. Ziegert HJ: Ein Fall von fieberhafter Wucheratrophie dies Fettegewebes (Weber-Christian Krankheit), Zentralbl. f. inn. Med. 61: 610-612, 1940. Google Scholar42. Christian HA: Oxford medicine, 1934, Oxford Press, New York, V. 4, part 4, p. 804 (55-58). Google Scholar43. SteinbrockerSpitzerFriedman ONHH: The shoulder-hand syndrome in reflex dystrophy of the upper extremity, Ann. Int. Med. 29: 22-52, 1948. LinkGoogle Scholar44. Osler W: The principles and practice of medicine, 1942, D. Appleton-Century, New York, pp. 472, 1187. Google Scholar HartwellThannhauser ASSJ: Case presentation and discussion of relapsing, febrile, nodular, nonsuppurative panniculitis, Bull. New England M. Center 2: 362-368, 1940. Google Scholar Puente JJ: Panniculitis nodular recidivante febrile de origen estafilocóccico. Un caso de granuloma lipofágico de la mama, Rev. Uruguaya de Derm. y Sif., 1938, Ano iii, No. 9, 52. Google Scholar Sweitzer S: Relapsing, febrile, nodular, nonsuppurative panniculitis, Arch. Dermat. and Syph. 43: 216, 1941. Google Scholar KennedyMurphy RJLR: Weber-Christian disease, Am. J. Med. 6: 672-680, 1949. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication May 7, 1949. 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ROBINSON, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., WILLIAM S. CLARK, M.D., DARRELL C. CRAIN, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., CHARLES RAGAN, M.D., F.A.C.P., MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P., CHARLEY J. SMYTH, M.D., F.A.C.P.RELAPSING FEBRILE NODULAR NONSUPPURATIVE PANNICULITIS (WEBER-CHRISTIAN SYNDROME): CASE REPORT WITH RESPONSE TO ROENTGEN THERAPY, AND FAILURE OF CORTISONE*SAMUEL H. SANDIFERWeber-Christian's DiseaseWEBER-CHRISTIAN'S DISEASE: A REPORT OF TWO CASES*ROBERT FRIEDENBERG, M.D., F.A.C.P. 1 May 1951Volume 34, Issue 5Page: 1179-1201KeywordsFevers ePublished: 1 December 2008 Issue Published: 1 May 1951 PDF downloadLoading ...