tbuckley/cabot-search huggingface dataset:
Adjunctive Risperidone Treatment for Antidepressant-Resistant Symptoms of Chronic Military Service–Related PTSD
Authors: John H. Krystal, Robert A. Rosenheck, Joyce A. Cramer, Jennifer C. Vessicchio, Karen M. Jones, Julia E. Vertrees, Rebecca A. Horney, Grant D. Huang, Christopher Stock
Journal: JAMA (2011)

Serotonin reuptake-inhibiting (SRI) antidepressants are the only FDA-approved pharmacotherapies for the treatment of posttraumatic stress disorder (PTSD).To determine efficacy of the second-generation antipsychotic risperidone as an adjunct to ongoing pharmacologic and psychosocial treatments for veterans with chronic military-related PTSD.A 6-month, randomized, double-blind, placebo-controlled multicenter trial conducted between February 2007 and February 2010 at 23 Veterans Administration outpatient medical centers. Of the 367 patients screened, 296 were diagnosed with military-related PTSD and had ongoing symptoms despite at least 2 adequate SRI treatments, and 247 contributed to analysis of the primary outcome measure.Risperidone (up to 4 mg once daily) or placebo.The Clinician-Administered PTSD Scale (CAPS) (range, 0-136). Other measures included the Montgomery-Asberg Depression Rating Scale (MADRS), Hamilton Anxiety Scale (HAMA), Clinical Global Impression scale (CGI), and Veterans RAND 36-Item Health Survey (SF-36V).Change in CAPS scores from baseline to 24 weeks in the risperidone group was -16.3 (95% CI, -19.7 to -12.9) and in the placebo group, -12.5 (95% CI, -15.7 to -9.4); the mean difference was 3.74 (95% CI, -0.86 to 8.35; t = 1.6; P = .11). Mixed model analysis of all time points also showed no significant difference in CAPS score (risperidone: mean, 64.43; 95% CI, 61.98 to 66.89, vs placebo: mean, 67.16; 95% CI, 64.71 to 69.62; mean difference, 2.73; 95% CI, -0.74 to 6.20; P = .12). Risperidone did not reduce symptoms of depression (MADRS mean difference, 1.19; 95% CI, -0.29 to 2.68; P = .11) or anxiety (HAMA mean difference, 1.16; 95% CI, -0.18 to 2.51; P = .09; patient-rated CGI mean difference, 0.20; 95% CI, -0.06 to 0.45; P = .14; observer-rated CGI mean difference, 0.18; 95% CI, 0.01 to 0.34; P = .04), or increase quality of life (SF-36V physical component mean difference, -1.13, 95% CI, -2.58 to 0.32; P = .13; SF-36V mental component mean difference, -0.26; 95% CI, -2.13 to 1.61; P = .79). Adverse events were more common with risperidone vs placebo, including self-reported weight gain (15.3% vs 2.3%), fatigue (13.7% vs 0.0%), somnolence (9.9% vs 1.5%), and hypersalivation (9.9% vs 0.8%), respectively.Among patients with military-related PTSD with SRI-resistant symptoms, 6-month treatment with risperidone compared with placebo did not reduce PTSD symptoms.clinicaltrials.gov Identifier: NCT00099983.
Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis
Authors: Carmen Rondón, José J. Romero, Soledad López, Cristina Antúnez, Enrique Martín-Casañez, Maria J. Torres, Cristobalina Mayorga, Rebeca R-Pena, Miguel Blanca
Journal: Journal of Allergy and Clinical Immunology (2007)
UN conference on AIDS settles on compromise statement
Authors: Janice Hopkins Tanne
Journal: BMJ (2006)

Last week's UN high level meeting on AIDS in New York agreed on a declaration of commitment that was stronger than some countries would have liked but weaker than what non-governmental and pressure groups wanted. Nevertheless, it goes further than the previous declaration of 2001.

The secretary general of the United Nations, Kofi Annan, said that the …
Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer
Authors: Catherine M. Bollard, Stephen Gottschalk, Ann M. Leen, Heidi Weiss, Karin C. Straathof, George Carrum, Mariam Khalil, Meng-fen Wu, M. Helen Huls, Chung-Che Chang, M. Victoria Gresik, Adrian P. Gee, Malcolm K. Brenner, Cliona M. Rooney, Helen E. Heslop
Journal: Blood (2007)
A Simplified Indicator-Dilution Technic for the Localization of Left-to-Right Circulatory Shunts
Authors: EUGENE BRAUNWALD, WILLIAM W. PFAFF, ROBERT T. L. LONG, ANDREW G. MORROW
Journal: Circulation (1959)

Indicator-dilution curves recorded from a systemic artery after injection in the right heart may show the presence of a left-to-right shunt but will not localize it. Injections into the left side of the heart with arterial sampling or into the pulmonary artery with right heart sampling provide accurate and sensitive methods for localization but the technics are inconvenient and sometimes impossible to apply. A simplified indicator method for the localization of left-to-right circulatory shunts is described.
Colposcopy in the Management of Early Cervical Neoplasia
Authors: G. Herbeck, F. Menken
Journal: Endoscopy (1977)

An outline of the capacity of colposcopy in detection of early neoplastic changes at the ectocervix and the cervical os is given. Figures are presented of results reached by combined use of colposcopy and cytology in 6,536 women (divided into age groups of over and under 30 years) including histological findings. The results emphasize the need to use colposcopy as an additional method in cervical cancer detection.
Ethical and Regulatory Issues in Pediatric Research Supporting the Non-Clinical Application of fMR Imaging
Authors: Wim Pinxten, Herman Nys, Kris Dierickx
Journal: The American Journal of Bioethics (2009)

Click to increase image sizeClick to decrease image size Acknowledgment The research for this publication was supported by the EuroCareCF Coordination Action (FP6–Contract nr. LSHMCT-2005-18932).
Demythologizing Medicine; or, How to Stop Worrying and Love the Computer
Authors: M. Therese Southgate
Journal: JAMA (1975)

In certain aspects of patient care, notes Kenneth Keele,<sup>1</sup>the physician of today differs little from the medicine man of a primitive tribe. Called to see a patient suffering from a mysterious disease, the medicine man always started with a careful history. What had the patient done (or failed to do) that could have caused his illness? Had he broken a tribal taboo? Had he offended a powerful neighbor? A god? Had he ignored a fetish? Sometimes, as is the case today, the history was only suggestive, and treatment could not be started because there was still no clear-cut cause for the symptoms. It was then that the medicine man had to consult with his spirits, most often through another medicine man who specialized in contacting the spirit appropriate to the patient's symptoms. Often the medicine man had to go even further, to a specially constructed tower to consult
Treatment of Isoniazid Overdose
Authors: Maurice L. Sievers
Journal: JAMA (1982)

<h3>To the Editor.—</h3> The recent article by Wason et al (1981;246:1102) reemphasizes the efficacy of high-dose pyridoxine hydrochloride (vitamin B<sub>6</sub>) treatment of acute isoniazid overdose. During the past decade, in the Indian Health Service (IHS), more than 150 Native Americans with isoniazid overdose have been successfully treated with intravenous (IV) administration of pyridoxine in doses equivalent to the estimated amount of isoniazid ingested (personal experience of two of us—M.L.S. and R.N.H.—and personal communications from IHS physicians). In sufficient dosage, pyridoxine administered IV can reverse the severe toxic effects of isoniazid overdose and prevent death in humans and animals,<sup>1-5</sup>but the excessive amount of isoniazid ingested is often unknown. Furthermore, the large dose of pyridoxine that is recommended (equal to the estimated overdose of isoniazid<sup>1,2</sup>) may not be readily available in all hospitals. These circumstances may result in inadequate antidotal treatment with pyridoxine. If the response to pyridoxine
micronodular transpormation (nodular regenerative hyperplasia) of the liver: A report of 64 cases among 2,500 autopsies and a new classification of benign hepatocellular nodules
Authors: Ian R. Wanless
Journal: Hepatology (1990)

Nodular regenerative hyperplasia is defined by hepatocellular nodules distributed throughout the liver in the absence of fibrous septa between the nodules. Most reports have been single cases so that the prevalence and clinical significance of nodular regenerative hyperplasia is uncertain. In this study, the hepatic histology of 2,500 consecutive autopsies was reviewed. A spectrum of nodular transformation was found with nodular regenerative hyperplasia present in 2.6% of autopsy livers and qualitatively similar but lesser degrees of nodular transformation in a further 10.2%. Nodular transformation was also seen in 47% of livers with cirrhosis and 69% with incomplete cirrhosis. Obliteration of many small portal veins was seen in all cases with nodular regenerative hyperplasia, but only 4.7% of these had evidence of portal hypertension. The prevalence of various clinical states was compared in nodular regenerative hyperplasia and in controls. The results confirm, extend and quantify the spectrum of associated diseases. Nodular regenerative hyperplasia occurs in 5.6% of individuals over age 80 and with increased frequency in patients with systemic arteritis, polymyalgia rheumatica, massive tumor infiltration and mineral oil deposition. Nodular regenerative hyperplasia appears to be the hepatic analogue of arterial and arteriolar nephrosclerosis. A new classification of nodular transformation is proposed that encompasses the spectrum of lesions described here and the previously defined entities of focal nodular hyperplasia, partial nodular transformation and "cirrhosis telangiectasia hepatis." The major conclusion is that nodular regenerative hyperplasia is a secondary and nonspecific tissue adaptation to heterogeneous distribution of blood flow and does not represent a specific entity.
Immunomodulation and Sezary syndrome: experience with thymopentin (TP-5)
Authors: MARIA GRAZIA BERNENGO, G. C. DOVEIL, M. MEREGALLI, ANTONELLA APPINO, ROBERTA MASSOBRIO
Journal: British Journal of Dermatology (1988)

The clinical, histological and immunological effects of long‐term treatment with thymopentin (TP‐5), administered 50 mg i.v. three times a week on alternate days, in four patients with Sezary syndrome is reported. In all four cases reduction of itching, oedema, scaling and thickening, and clearing of erythroderma were noted after 2 months treatment. Peripheral blood Sezary cells decreased in three cases. Reduction or suspension of the drug was followed by a clinical relapse. A loss of epidermotropism and a reduction in cell infiltrates were observed together with a dramatic reduction in epidermal and dermal Langerhans cells. An increase in the proliferative response to mitogens and in IFN‐y production, and the expression of activation antigens in PHA stimulated cultures occurred after 3 months. HNK‐ 1 + cells increased both in the peripheral blood and in the dermis following a transient increase in IL‐2 receptors, suggesting that clinical response in TP‐5 treated patients may be mediated by an incrased production of IL‐2 and consequent generation of cytotoxic cells or release of lymphokines able to augment NK activity.
The effects of adriamycin on normal and ouabain-toxic canine Purkinje and ventricular muscle fibers.
Authors: O Binah, I S Cohen, M R Rosen
Journal: Circulation Research (1983)

In the "Na+ lag hypothesis" of cardiac glycoside action, [Ca++]i increases through sodium-calcium exchange following block of the sodium-calcium ATPase. This accumulation of [Ca++]i has been suggested to be responsible for digitalis-induced delayed after depolarizations and arrhythmias. We used standard microelectrode techniques to study the effects of adriamycin, 10-200 microM, on the canine Purkinje fiber transmembrane potential. Adriamycin, 10 and 50 microM, had no effect on the action potential other than inducing a 28% increase in duration at 50 microM (p less than 0.01). Adriamycin, 100 and 200 microM, further prolonged action potential duration and decreased amplitude and Vmax. We then studied the effects of adriamycin, 50 microM (a concentration that purportedly blocks sodium-calcium exchange), on ouabain-induced delayed afterdepolarizations and aftercontractions in Purkinje fiber and ventricular muscle. After initially increasing delayed afterdepolarization amplitude in five of nine Purkinje fibers, adriamycin reversibly reduced their amplitude in all nine, by 78%, at a drive cycle length of 500 msec (P less than 0.01). Adriamycin, 50 microM, had no effect on calcium ion-induced slow response action potentials, suggesting this concentration does not significantly reduce the slow inward current. In ventricular muscle, adriamycin, 50 microM, did not significantly reduce contraction but did depress aftercontractions (P less than 0.025). In sum: in concentrations that have no effect on the AP other than prolonging duration, adriamycin, 50 microM, reversibly depresses ouabain-induced delayed afterdepolarizations and aftercontractions; however, adriamycin, 50 microM, does not depress calcium ion-dependent action potentials. Although the action of adriamycin on delayed afterdepolarizations and aftercontractions is consistent with direct inhibition of the transient inward current and/or an indirect reduction via reduced activity of sodium-calcium exchange, whether either or both of these mechanisms is involved must be defined by further experimentation.
The Importance of Efficient Depression Management in Primary Care
Authors: Lisa V. Rubenstein, Kimberly A. Hepner
Journal: Annals of Internal Medicine (2008)

Letters1 April 2008The Importance of Efficient Depression Management in Primary CareLisa V. Rubenstein, MD, MSHS and Kimberly A. Hepner, PhDLisa V. Rubenstein, MD, MSHSFrom RAND Health Program, Santa Monica, CA 90407.Search for more papers by this author and Kimberly A. Hepner, PhDFrom RAND Health Program, Santa Monica, CA 90407.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-148-7-200804010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We thank Drs. Theleritis and colleagues for pointing out the importance of depression in causing increased mortality due to suicide. As they say, the adverse effects of depression on cardiovascular health and other chronic disease outcomes are well documented. We agree that these effects, in combination with the low quality of care we observed, are cause for alarm. Our comments on mortality related to depression come from a different perspective, however, and we are grateful for the opportunity to clarify.For many conditions, avoidance of death and hospitalization are critical drivers for quality improvement. For patients hospitalized with ...Reference1. Gilbody S, Whitty P, Grimshaw J, Thomas R. Educational and organizational interventions to improve the management of depression in primary care: a systematic review. JAMA. 2003;289:3145-51. [PMID: 12813120] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From RAND Health Program, Santa Monica, CA 90407.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDepression Decision Support in Primary Care: A Cluster Randomized Trial Steven K. Dobscha , Kathryn Corson , David H. Hickam , Nancy A. Perrin , Dale F. Kraemer , and Martha S. Gerrity The Effect of Adherence to Practice Guidelines on Depression Outcomes Kimberly A. Hepner , Melissa Rowe , Kathryn Rost , Scot C. Hickey , Cathy D. Sherbourne , Daniel E. Ford , Lisa S. Meredith , and Lisa V. Rubenstein The Importance of Efficient Depression Management in Primary Care Christos G. Theleritis , Thomas J. Paparrigopoulos , and George N. Papadimitriou Metrics 1 April 2008Volume 148, Issue 7Page: 562-563KeywordsHealth care qualityHeart failureHospitalizationsLongitudinal studiesPsychiatry and mental healthQuality improvementSuicideVeteran care ePublished: 1 April 2008 Issue Published: 1 April 2008 CopyrightCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Antibiotic Therapy and Chronic Obstructive Pulmonary Disease
Authors: WINSLOW ENGEL
Journal: Annals of Internal Medicine (1987)

Letters and Corrections1 October 1987Antibiotic Therapy and Chronic Obstructive Pulmonary DiseaseWINSLOW ENGEL, M.D.WINSLOW ENGEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-107-4-596_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The excellent study by Anthonisen and associates (1) contained much careful reasoning in the section on clinical significance. However, it is on the question of clinical significance that I would like to make a criticism or, at least, request additional information.The authors combined several different symptoms (dyspnea, sputum volume, and purulence) in their definition of an exacerbation and the determination of treatment success or failure. Similarly, their definition of deterioration included both hospitalization and unblinded subsequent treatment with antibiotics. My concern is that, by reporting only on these multidimensional outcome measures, the true clinical significance of...Reference1. ANTHONISEN N, MANFREDA J, WARREN C, HERSHFIELD E, HARDING G, and NELSON N. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med. 1987;106:196-204. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WINSLOW ENGEL, M.D.Affiliations: The University of North Carolina at Chapel Hill Chapel Hill, NC 27514 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1987Volume 107, Issue 4Page: 596-597KeywordsAntibioticsChronic obstructive pulmonary diseaseDyspneaHospitalizationsReasoningSputum ePublished: 1 December 2008 Issue Published: 1 October 1987 PDF downloadLoading ...
Adoptive transfer of rapidly-generated multivirus-specific T cells to treat Adv, EBV, CMV, BK and HHV6 infections of HSCT recipients
Authors: Anastasia Papadopoulou, Usha Katari, Ulrike Gerdemann, Caridad Martinez, Kathy Leung, George Carrum, Adrian Gee, Juan Vera, Robert Krance, Malcolm Brenner, Cliona Rooney, Helen Heslop, Ann Leen
Journal: Journal for ImmunoTherapy of Cancer (2013)

Meeting abstracts Severe and fatal viral infections remain common after HSCT. Adoptive transfer of cytotoxic T lymphocytes (CTLs) specific for EBV, CMV and Adv antigens can treat infections that are impervious to conventional therapies, but extension to additional viruses has been limited by
Effect of hypertonic mannitol infusion during prolonged coronary occlusion
Authors: E. R POWERS, P. J CANNON
Journal: Cardiovascular Research (1983)

Previous studies investigating the effect of hypertonic mannitol infusion during coronary occlusion have yielded conflicting results. The present study investigated the effect of hypertonic mannitol infusion on regional myocardial blood flow (microsphere technique), a metabolic index of ischaemic severity (myocardial PCO2 (PmCO2] and myocardial water accumulation during a 2 h anterior descending coronary artery (LAD) occlusion in open chest anaesthetised dogs. In seven dogs studied without mannitol intervention, LAD ligation resulted in an initial fall in regional blood flow to 25% of control flow followed by no significant change thereafter. Myocardial PCO2 distal to the ligation rose to a peak of 34.0 +/- 4.4 kPa (256 +/- 89) (mean +/- SEM). At the completion of the 2 h ischaemia period, myocardial water content was 8.4% greater in ischaemic than non-ischaemic tissue (3.87 +/- 0.11 and 3.57 +/- 0.03 g X g-1 dry weight respectively). In seven additional dogs, mannitol infusion begun 12 min following occlusion resulted in an increase in plasma osmolarity from 304 +/- 5 to 346 +/- 8 mosmol X litre-1, but failed to influence regional flow, PmCO2, or water accumulation in the ischaemic tissue. The inability of mannitol to favourably influence the severity of myocardial ischaemia during prolonged coronary occlusion may be due to its inability to prevent myocardial cell swelling in this model.
Abstract 15999: Electrocardiographic Changes Associated With Prognosis in Pulmonary Arterial Hypertension
Authors: Eric R Fenstad, Rachel J Le, Michael D McGoon, Robert P Frantz, Thomas M Munger, Garvan C Kane
Journal: Circulation (2011)

Introduction: Electrocardiographic findings in patients with pulmonary arterial hypertension (PAH) have been described previously in a small cohort. However the prognostic significance of these fin...
TULAREMIA AND CONJUNCTIVITIS
Authors: W. R. Morrison
Journal: JAMA (1926)

<h3>To the Editor:</h3> —The ocular glandular type of tularemia so accurately coincides with the clinical manifestation of Parinaud's conjunctivitis in its local and general symptoms and clinical course as to suggest that Parinaud's conclusions were well founded when he contended that the infection was of animal origin. Two cases of tularemia that I recently reported at the meeting of the Montana State Medical Association are so accurately described in de Schweinitz' textbook under the heading Parinaud's Conjunctivitis as to leave little to be added in a description of these cases. Positive blood findings as reported from the Hygienic Laboratory in Washington conclusively established the etiologic factor as that of tularemia.
Psychological profiling of young female handball and basketball players - a pilot study
Authors: Y Shima, K Kitaoka, J Nakase, K Goshima, R Takahashi, S Tsukagoshi, Y Yoneda, S Moriyama, Y Ogawa, H Tsuchiya
Journal: British Journal of Sports Medicine (2011)

Background The influence of psychological factors on injuries in female handball and basketball is poorly documented. Objective The aim of this study was to examine the influence of psychological factors on injuries in female handball and basketball players, especially for non-contact anterior cruciate ligament (ACL) injuries. Design Case control study. Setting and Participants A three-year prospective cohort study has been initiated in Japanese young female handball and basketball players to identify risk factors for non-contact ACL injuries. At baseline, 99 of 104 young female players (handball: 30 players, basketball: 69 players, age;15–16 years) were asked to complete a detailed questionnaire covering player history, previous injuries, KOOS, personality and psychological-competitive ability using the Y-G personality questionnaire and questionnaire for diagnostic inventory of psychological-competitive ability score (DIPCA-3). Results There were no correlation between KOOS and DIPCA-3, and no significant differences were found between handball players and basketball players. There were no significant differences between previously injured and non-injured players in the score of KOOS and DIPCA-3. The players evaluated as D (director) type by the Y-G personality questionnaire scored significantly better result in DIPCA-3 than the A (average), B (burst), E (engineer) type (p=0.0128, p=0.001, p&lt;0.001, respectively). Conclusion Since perceived mastery climate has been reported as a significant predictor for new injuries, the players who has high psychological-competitive ability evaluated as D type may be the injury-prone athletes. Prospective follow-up is necessary to elucidate whether high psychological-competitive ability is a risk factor for ACL injury or new injury.