Hairy Cell Leukemia: In-Vitro Culture Studies
Authors: DAVID W. GOLDE
Journal: Annals of Internal Medicine (1976)

Letters1 July 1976Hairy Cell Leukemia: In-Vitro Culture StudiesDAVID W. GOLDE, M.D., F.A.C.P., SHIRLEY G. QUAN, M.A., MARTIN J. CLINE, M.D., F.A.C.P.DAVID W. GOLDE, M.D., F.A.C.P.Search for more papers by this author, SHIRLEY G. QUAN, M.A.Search for more papers by this author, MARTIN J. CLINE, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-1-78 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHairy cell leukemia, or leukemic reticuloendotheliosis, is a well-defined clinical entity characterized by peripheral blood cytopenias and diffuse infiltration of the bone marrow and spleen by neoplastic cells with hairlike projections (1). The hairy cell has a unique morphology and may be identified easily by the histochemical demonstration of large amounts of tartrate-resistant acid phosphatase (2). It is important to differentiate this condition from other hematopoietic malignancies as the treatment of choice appears to be splenectomy rather than chemotherapy (1, 2).There has been considerable divergence of opinion regarding the nature of the neoplastic cell. Substantial evidence has accumulated for...References1. KATAYAMA I and FINKEL H: Leukemic reticuloendotheliosis. A clinicopathologic study with review of the literature. Am J Med 57:115-125, 1974 CrossrefMedlineGoogle Scholar2. YAM L, LI C, and FINKEL H: Leukemic reticuloendotheliosis. The role of tartrate-resistant acid phosphatase in diagnosis and splenectomy in treatment. Arch Intern Med 130:248-256, 1972 CrossrefMedlineGoogle Scholar3. GOLDE D: Disorders of mononuclear phagocyte proliferation, maturation, and function. Clinics in Haematology 4:705-721, 1975 CrossrefMedlineGoogle Scholar4. GOLDE D, ROTHMAN B, and CLINE M: Production of colony-stimulating factor by malignant leukocytes. Blood 43:749-756, 1974 CrossrefMedlineGoogle Scholar5. CATOVSKY D, PETTIT J, and GALETTO J: The B-lymphocyte nature of the hairy cell of leukaemic reticuloendotheliosis. Br J Haematol 26:29-37, 1974 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID W. GOLDE, M.D., F.A.C.P.; SHIRLEY G. QUAN, M.A.; MARTIN J. CLINE, M.D., F.A.C.P.Affiliations: Division of Hematology-Oncology Department of Medicine UCLA School of Medicine Los Angeles, CA 90024 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCommercial Development of Human Cell Lines — Property, Ethics, and Conflict of InterestAltered Basement Membrane Structure of the Spleen in Hairy Cell LeukaemiaHairy Cell Leukemia: Advances in the Immunologic Evaluation and Identification of a Normal Counterpart CellHairy cell leukemia: Kinetics and intercellular relationships of cells in leukemic colonies grown in a semisolid mediumKlinik der malignen LymphomeHairy cell leukemia: Clinical effects of the methanol extraction residue (MER) of BCG, lithium carbonate and mononuclear cell-enriched leukocyte transfusionsHaarzell-LeukämieReferencesNierenkarzinom bei Haarzell-Leuk�mieHairy Cell Leukaemia: Seven Cases with Probable B-Lymphocytic OriginKulturverhalten wei�er Blutzellen bei Patienten mit Haarzell-Leuk�mie in der DiffusionskammerImmunoglobulin Synthesis in Hairy Cell LeukaemiaMacroglobulinemia and Hairy-Cell LeukemiaHairy Cells in Long-Term CulturesJOSEPH G. SINKOVICS, M.D., F.A.C.P., FERENC GYÖRKEY, M.D., PHYLLIS GYÖRKEY, B.S., CHIU-HWA WANG, M.D. 1 July 1976Volume 85, Issue 1Page: 78-79KeywordsAcid phosphataseBlood cellsBone marrowBone marrow cellsCell culturesChemotherapyHematologic malignanciesSpleenSplenectomy ePublished: 1 December 2008 Issue Published: 1 July 1976 PDF downloadLoading ...