tbuckley/cabot-search huggingface dataset:
Influence of Diabetes Mellitus on Early and Late Outcome After Percutaneous Transluminal Coronary Angioplasty
Authors: Bernardo Stein, William S. Weintraub, Suzanne S.P. Gebhart, Caryn L. Cohen-Bernstein, Ralph Grosswald, Henry A. Liberman, John S. Douglas, Douglas C. Morris, Spencer B. King
Journal: Circulation (1995)

Background Although patients with diabetes mellitus constitute an important segment of the population undergoing coronary angioplasty, the outcome of these patients has not been well characterized. Methods and Results Data for 1133 diabetic and 9300 nondiabetic patients undergoing elective angioplasty from 1980 to 1990 were analyzed. Diabetics were older and had more cardiovascular comorbidity. Insulin-requiring (IR) diabetics had diabetes for a longer duration and worse renal and ventricular functions compared with non-IR subjects. Angiographic and clinical successes after angioplasty were high and similar in diabetics and nondiabetics. In-hospital major complications were infrequent (3%), with a trend toward higher death or myocardial infarction in IR diabetics. Five-year survival (89% versus 93%) and freedom from infarction (81% versus 89%) were lower, and bypass surgery and additional angioplasty were required more often in diabetics. In diabetics, only 36% survived free of infarction or additional revascularization compared with 53% of nondiabetics, with a marked attrition in the first year after angioplasty, when restenosis is most common. Multivariate correlates of decreased 5-year survival were older age, reduced ejection fraction, history of heart failure, multivessel disease, and diabetes. IR diabetics had worse long-term survival and infarction-free survival than non-IR diabetics. Conclusions Coronary angioplasty in diabetics is associated with high success and low complication rates. Although long-term survival is acceptable, diabetics have a higher rate of infarction and a greater need for additional revascularization procedures, probably because of early restenosis and late progression of coronary disease. The most appropriate treatment for these patients remains to be determined.
Case of a Nail Passing Safely Though the Alimentary Canal of a Baby
Authors: B. Blower
Journal: BMJ (1870)

been well destroyed.There was no bleeding.On the Igth, the sloughs, which were very deep, had nearly come away.During the process of separation, the odour had been very feetid.The edges of the wound were beginning to be covered with mucous membrane.On the 23rd, she had improved rapidly; the wound was greatly cicatrised.A few dubious points remained here and there.On December 2nd, catamenia had appeared; they were much less copious than usual, and more like oozing: no clots.On examining her to-day, it was found
The murmur of pulmonic regurgitation in tetralogy of Fallot with absent pulmonic valve.
Authors: M E Fontana, C F Wooley
Journal: Circulation (1978)

Absent pulmonic valve (APV) in tetralogy of Fallot produces a pulmonic regurgitation murmur (PRM) which is usually late in onset after A2, low pitched, and of crescendo-decrescendo character. We have seen three adult patients with tetralogy of Fallot with APV and have done intracardiac sound and pressure studies in two. The PRM was loudest in the RV outflow tract (RVOT), where the onset was earlier than the murmur recorded on the chest wall. The crescendo portion of the PRM occurred during an abnormally slow decline in the RVOT pressure pulse after the crossover of PA and RVOT pressures. The RVOT pressure reached its minimum 30 msec after the RV body pressure, resulting in a pressure gradient between the two. The PRM peaked 30 msec later in the RV body than in the RVOT. The delayed precordial onset of the PRM after A2 is likely due to failure of transmission of early vibrations through the chest wall. The morphology of the PRM in tetralogy of Fallot with APV may be related to delayed relaxation with altered diastolic compliance of the RVOT which is subjected to a large regurgitant volume from the massively dilated pulmonary arteries.
Characterization of inactive renin ("prorenin") from renin-secreting tumors of nonrenal origin. Similarity to inactive renin from kidney and normal plasma.
Authors: S A Atlas, T E Hesson, J E Sealey, B Dharmgrongartama, J H Laragh, M C Ruddy, M Aurell
Journal: Journal of Clinical Investigation (1984)

Inactive renin comprises well over half the total renin in normal human plasma. There is a direct relationship between active and inactive renin levels in normal and hypertensive populations, but the proportion of inactive renin varies inversely with the active renin level; as much as 98% of plasma renin is inactive in patients with low renin, whereas the proportion is consistently lower (usually 20-60%) in high-renin states. Two hypertensive patients with proven renin-secreting carcinomas of non-renal origin (pancreas and ovary) had high plasma active renin (119 and 138 ng/h per ml) and the highest inactive renin levels we have ever observed (5,200 and 14,300 ng/h per ml; normal range 3-50). The proportion of inactive renin (98-99%) far exceeded that found in other patients with high active renin levels. A third hypertensive patient with a probable renin-secreting ovarian carcinoma exhibited a similar pattern. Inactive renins isolated from plasma and tumors of these patients were biochemically similar to semipurified inactive renins from normal plasma or cadaver kidney. All were bound by Cibacron Blue-agarose, were not retained by pepstatin-Sepharose, and had greater apparent molecular weights (Mr) than the corresponding active forms. Plasma and tumor inactive renins from the three patients were similar in size (Mr 52,000-54,000), whereas normal plasma inactive renin had a slightly larger Mr than that from kidney (56,000 vs. 50,000). Inactive renin from each source was activated irreversibly by trypsin and reversibly by dialysis to pH 3.3 at 4 degrees C; the reversal process followed the kinetics of a first-order reaction in each instance. The trypsin-activated inactive renins were all identical to semipurified active renal renin in terms of pH optimum (pH 5.5-6.0) and kinetics with homologous angiotensinogen (Michaelis constants, 0.8-1.3 microM) and inhibition by pepstatin or by serial dilutions of renin-specific antibody. These results indicate that a markedly elevated plasma inactive renin level distinguishes patients with ectopic renin production from other high-renin hypertensive states. The co-production of inactive and active renin by extrarenal neoplasms provides strong presumptive evidence that inactive renin is a biosynthetic precursor of active renin. The unusually high proportion of inactive renin in plasma and tumor extracts from such patients is consistent with ineffective precursor processing by neoplastic tissue, suggesting that if activation of "prorenin" is involved in the normal regulation of active renin levels it more likely occurs in the tissue of origin (e.g., kidney) than in the circulation.
Some Aspects of Acute Haematogenous Osteitis in Children
Authors: T. S. Mann
Journal: BMJ (1963)

Doctor's Duty This real risk of further and more serious injury means that not only must we recognize the syndrome for what it is, we must also report the cases to the police.We cannot return children to parents in whose care they may have a 10% chance of violent death.Doctors are reluctant to believe that such assaults on innocent babies are possible, and they are even more reluctant to become involved in the squalor of criminal proceedings, but in the interests of some of our most helpless patients we must realize that epiphysial trauma is due to violence and that not all parents, even if warned, are safe custodians. SummaryFive cases of multiple epiphysial injuries in babies are described which illustrate the classical features of the con- dition-namely, (1) unexplained swelling in a baby's limb, (2) characteristic x-ray changes, (3) elevation of tempera- ture, (4) leucocytosis.Typical x-ray appearances are described, and it is emphasized that the diagnosis can be made from these rather than from the clinical history, from which a story of trauma is often conspicuously absent.The conditions must be differentiated from scurvy, osteomyelitis, and congenital indifference to pain, and should not be confused with the other form of " Caffey's disease "-namely, infantile cortical hyperostosis.The mode of production of these injuries is described and a plea is made for recog- nition of this syndrome and the desirability of reporting such cases to the police in order to minimize the risk of further injuries being inflicted upon these children.Three of the patients whose cases we report were admitted under the care of Messrs. T. T. Stamm, J. S. Batchelor, and P. G.
A Psychopathological Reaction Precipitated by Sensory Deprivation
Authors: GEORGE C. CURTIS, MARVIN ZUCKERMAN
Journal: American Journal of Psychiatry (1968)

A young male subject developed an acute psychotic reaction during an eight-hour sensory deprivation experiment. His delusions lasted several days, and severe anxiety and depression lasted several weeks. This is the third reported case of such a prolonged reaction.
Medicine--a victim of fashion?
Authors: D. Spence
Journal: BMJ (2008)

I knew what I wanted to study at university and didn’t want to see the careers officer, but I had to go. He looked at my grades, and it was clear that the geek alarm bells had started ringing in his mind. “So you want to do medicine? It is very demanding,” he said. “Have you considered law or accountancy?” An imaginary pistol was cocked against my temple. “No,” I replied, “I am sure I want to be a doctor.” I worked to …
Ultrastructural evidence for the presence of ferritin-iron in the biliary system of patients with iron overload
Authors: Maud I. Cleton, Jan W. Sindram, Louk H. P. M. Rademakers, Floris M. J. Zuyderhoudt, Willem C. De Bruijn, Joannes J. M. Marx
Journal: Hepatology (1986)

Ferritin-like particles were observed in bile canaliculi of patients with iron overload. These particles have been further investigated by: (1) a staining method enhancing the size and contrast of ferritin protein, and (2) electronprobe microanalysis detecting the presence of the elements iron and phosphorus. Morphological observation of coated vesicles in the cytoplasm adjacent to the bile canaliculi and coated pits in the canalicular membrane suggests a transport mechanism via membrane-bound organelles. Support is given to the theory that part of the iron, stored in the liver, leaves the hepatocyte by excretion of ferritininto the bile.
Intrapartum Fetal Monitoring — A Disappointing Story
Authors: Roger Freeman
Journal: New England Journal of Medicine (1990)

Intrapartum electronic fetal-heart-rate monitoring was introduced in the United States in the early 1970s after studies supported the existence of a correlation between patterns of fetal heart rate and signs of fetal hypoxia — specifically, intrapartum fetal death, fetal blood pH, and Apgar scores.1 , 2 The common perception was that with this objective technique, evidence of fetal hypoxia would appear in a timely fashion, allowing the clinician to intervene and thus protect the fetus from the ravages of continued intrauterine oxygen deprivation. It was believed then that the intrapartum period was an especially treacherous time for the fetus, when most hypoxic . . .
Injuries: Causes, Control Strategies, and Public Policy
Authors: Theodore C. Doege
Journal: JAMA (1984)

Although no health problem is of greater "impact," injuries generally receive little public attention. Physicians traditionally limit their concerns to the proper treatment of the injured, and those in biomedical research rarely carry out thorough studies of injuries and their prevention. This short book gives emphasis to the injury problem, reviews some of the epidemiologic factors involved, and focuses on control. It is a worthwhile contribution. A useful, modern concept concerning injuries is that they involve different types of energy, specifically, kinetic, chemical, electrical, thermal, and radiation energy. Professor Robertson, now a Yale faculty member, describes how each type can injure humans. A separate chapter provides brief but up-to-date information on the incidence and economic costs of injuries. One section of the book focuses on an approach to prevention that considers host, agent, and environmental factors, which in turn can be affected by preinjury, injury, and postinjury modifiers. While that
Spontaneous Femoral Osteonecrosis: Correlation with MRI
Authors: HOLLEY M. DEY, ROBERT H. JAROS, CHANNING S. SWAN, HASSANALI KASSAMALI
Journal: Clinical Nuclear Medicine (1988)

Radionuclide bone scanning allowed early diagnosis of spontaneous osteonecrosis of the knee, characterized by intense increased uptake of tracer in the affected condyle. A cold lesion was not identified. Magnetic resonance imaging confirmed the diagnosis.
Neutral endopeptidase (EC 3.4.24.11) in labial salivary glands in healthy controls and in patients with Sjogren's syndrome.
Authors: Y T Konttinen, J Tornwall, P Kemppinen, H Uusitalo, T Sorsa, M Hukkanen, J M Polak
Journal: Annals of the Rheumatic Diseases (1996)

OBJECTIVE: Neuropeptides from nerve fibres can cause neurogenic inflammation. The potency of these peptides in vitro has led to the hypothesis that enzyme degradative systems are operative in vivo to limit their action. To consider this question neutral endopeptidase (NEP) in labial salivary glands in patients with Sjögren9s syndrome was studied. METHODS: Synthesis of NEP mRNA in situ in labial salivary glands was studied using the reverse transcriptase polymerase chain reaction (RT-PCR). Immunohistochemical staining was used to localise the NEP enzyme protein and its neuropeptide substrates and fluorophotometry to measure the corresponding enzyme activities in saliva. RESULTS: NEP was found in nerve fibres and in perivascular, periductal, and periacinar axon terminal varicosities. Double labelling of PGP 9.5 and NEP confirmed this neuronal localisation of NEP. Although some fibroblast-like cells and occasional intravascular neutrophils were NEP positive, NEP mRNA was not found in labial salivary glands. Patients with Sjögren9s syndrome and healthy controls did not have nerves containing NEP or neuropeptides (vasoactive intestinal peptide, substance P, or calcitonin gene related peptide (CGRP)) in lymphocyte foci. Salivary NEP activity was not decreased in patients compared with controls. CONCLUSION: NEP in labial salivary glands is almost totally of neuronal origin and plays a part in proteolytic modulation of neuropeptides in salivary glands and saliva. These regulatory interactions seem to be altered in focal lymphocyte accumulations in Sjögren9s syndrome.
Association Between Bone Mineral Density and Serum Lipids in Men
Authors: Silvano Adami
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Role of HCV infection in the development of lymphoproliferative disorders in organ transplant recipients (OT)
Authors: A. Buda, A.L.P. Caforio, F. Calabrese, S. Pevere, S. Fagiuoli, S. Aversa, G. Gambino, U. Cillo, M. Valente, P. Burra
Journal: Journal of Hepatology (2000)
Metabolic, Hormonal, and Vascular Changes after Synthetic Oestrogen Therapy in Oophorectomized Women
Authors: S. Gow, I. MacGillivray
Journal: BMJ (1971)

Mestranol, the three-methyl ether form of ethinyloestradiol and one of the two oestrogens used in oral contraceptive steroids, was administered in a dose of 0·02 mg daily for 120 days to 25 oophorectomized women. Urinary oestriol and pregnanediol excretions were unaffected by the mestranol treatment but there was a shift of the maturation index of the vaginal smear to the right, indicating a correction of the pretreatment oestrogen deficiency. No significant change in the blood pressure or electrocardiograph recordings occurred during this relatively short period of administration. A significant rise in the serum protein-bound iodine, which might be regarded as an undesirable effect of mestranol on a long-term basis, occurred. Hepatic function as measured by bromsulphthalein was not impaired by the treatment. Mestranol had no effect on the total body water or on the total exchangeable potassium of the women. Its two most serious adverse effects were impairment of glucose tolerance and a high incidence (16%) of venous thrombo-embolic disease. The gravity of the adverse effects far outweighs any beneficial ones and precludes the use of mestranol alone for long-term hormone replacement therapy in postmenopausal women.
Coronatine Promotes Pseudomonas syringae Virulence in Plants by Activating a Signaling Cascade that Inhibits Salicylic Acid Accumulation
Authors: Xiao-yu Zheng, Natalie Weaver Spivey, Weiqing Zeng, Po-Pu Liu, Zheng Qing Fu, Daniel F. Klessig, Sheng Yang He, Xinnian Dong
Journal: Cell Host & Microbe (2012)
Delivery of Evidence-Based Treatment for Multiple Anxiety Disorders in Primary Care
Authors: Peter Roy-Byrne, Michelle G. Craske, Greer Sullivan, Raphael D. Rose, Mark J. Edlund, Ariel J. Lang, Alexander Bystritsky, Stacy Shaw Welch, Denise A. Chavira, Daniela Golinelli, Laura Campbell-Sills, Cathy D. Sherbourne, Murray B. Stein
Journal: JAMA (2010)

Improving the quality of mental health care requires moving clinical interventions from controlled research settings into real-world practice settings. Although such advances have been made for depression, little work has been performed for anxiety disorders.To determine whether a flexible treatment-delivery model for multiple primary care anxiety disorders (panic, generalized anxiety, social anxiety, and posttraumatic stress disorders) would be better than usual care (UC).A randomized controlled effectiveness trial of Coordinated Anxiety Learning and Management (CALM) compared with UC in 17 primary care clinics in 4 US cities. Between June 2006 and April 2008, 1004 patients with anxiety disorders (with or without major depression), aged 18 to 75 years, English- or Spanish-speaking, were enrolled and subsequently received treatment for 3 to 12 months. Blinded follow-up assessments at 6, 12, and 18 months after baseline were completed in October 2009.CALM allowed choice of cognitive behavioral therapy (CBT), medication, or both; included real-time Web-based outcomes monitoring to optimize treatment decisions; and a computer-assisted program to optimize delivery of CBT by nonexpert care managers who also assisted primary care clinicians in promoting adherence and optimizing medications.Twelve-item Brief Symptom Inventory (BSI-12) anxiety and somatic symptoms score. Secondary outcomes included proportion of responders (> or = 50% reduction from pretreatment BSI-12 score) and remitters (total BSI-12 score < 6).A significantly greater improvement for CALM vs UC in global anxiety symptoms was found (BSI-12 group mean differences of -2.49 [95% confidence interval {CI}, -3.59 to -1.40], -2.63 [95% CI, -3.73 to -1.54], and -1.63 [95% CI, -2.73 to -0.53] at 6, 12, and 18 months, respectively). At 12 months, response and remission rates (CALM vs UC) were 63.66% (95% CI, 58.95%-68.37%) vs 44.68% (95% CI, 39.76%-49.59%), and 51.49% (95% CI, 46.60%-56.38%) vs 33.28% (95% CI, 28.62%-37.93%), with a number needed to treat of 5.27 (95% CI, 4.18-7.13) for response and 5.50 (95% CI, 4.32-7.55) for remission.For patients with anxiety disorders treated in primary care clinics, CALM compared with UC resulted in greater improvement in anxiety symptoms, depression symptoms, functional disability, and quality of care during 18 months of follow-up.clinicaltrials.gov Identifier: NCT00347269.
Biologic ex-vivopre differentiation of adult bone marrow-derived mesenchymal stem cells for cardiac repair in a chronic dog model of myocardial infarction
Authors: Jozef Bartunek, Jeffrey D. Croissant, Jeannie G. Liu, Ike W. Lee, Bernard De Bruyne, William Wijns, Martin Penicka, Marc Vanderheyden, Bernard Gerber, Jean-Louis J. Vanoverschelde, Guy R. Heyndrickx
Journal: Journal of the American College of Cardiology (2003)
Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice.
Authors: S L Hofmann, D L Eaton, M S Brown, W J McConathy, J L Goldstein, R E Hammer
Journal: Journal of Clinical Investigation (1990)

Lp(a) lipoprotein purified from human plasma bound with high affinity to isolated bovine LDL receptors on nitrocellulose blots and in a solid-phase assay. Lp(a) also competed with 125I-LDL for binding to human LDL receptors in intact fibroblasts. Binding led to cellular uptake of Lp(a) with subsequent stimulation of cholesterol esterification. After intravenous injection, human Lp(a) was cleared slowly from the plasma of normal mice. The clearance was markedly accelerated in transgenic mice that expressed large amounts of LDL receptors. We conclude that the covalent attachment of apo(a) to apo B-100 in Lp(a) does not interfere markedly with the ability of apo B-100 to bind to the LDL receptor and that this receptor has the potential to play a major role in clearance of Lp(a) from the circulation of intact humans.
WHO urges "coverage for all, not coverage of everything"
Authors: P. Brown
Journal: BMJ (1999)

Governments must ensure that good health care is accessible to everyone, but they should not attempt to provide all possible treatments, according to the World Health Organisation's annual report. The report was launched this week as the UN agency's member states gather for their annual assembly on 17 May.

The report suggests that governments must provide cost effective services to prevent and treat their nation's most pressing health problems, and so reduce the disproportionate burden of disease on the poor and help economic growth. But it marks a significant shift in the WHO's stance from …
Hysteria in Men
Authors: Eli Robins, James J. Purtell, Mandel E. Cohen
Journal: New England Journal of Medicine (1952)

PRIOR to 1618, hysteria was said to occur only in women. The writings of Hippocrates,1 Galen,2 Aretaeus3 and Celsus4 make clear their belief that the condition never occurred in men. Caroli Pisonis (Charles Lepois),5 in 1618, was probably the first to suggest that hysteria could occur in men as well as in women. Since then, many authors6 7 8 9 10 11 12 13 14 15 16 17 18 19 have reported what they term hysteria as occurring in men, although the frequency is low in men as compared with that in women.6 , 7 , 9 , 10 Briquet6 found that in 430 cases diagnosed hysteria only 1.6 per cent occurred in men; Savill,9 from a study of . . .