tbuckley/cabot-search huggingface dataset:
Telomere Length in Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia
Authors: Ayman Saad, Shin Mineishi, Racquel Innis-Shelton
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1543: Up-regulation of CD52 enhances the resistance against bortezomib in multiple myeloma cells
Authors: Jeong In Oh, Juwon Park, Chansu Lee, Byung-Su Kim, Jung Hye Kwon, Byoung Kook Kim, Kwang-Sung Ahn, Sung-Soo Yoon
Journal: Cancer Research (2010)

Abstract Bortezomib has excellent clinical activity in patients with multiple myeloma (MM). Clinical efficacy has been hampered by the emergence of drug-resistance phenomena. Verification of molecular mechanism by which resistance emerges is crucial for improved treatment outcome in MM. In this study, we established bortezomib resistance MM cells (U266/velR) and examined the biologic characteristics. In microarray analysis, 294 genes expressions were changed more than two-fold or greater and seven putative genes were selected by further analyzing microarray dataset. Those gene expressions between U266/velR and its control were confirmed using real-time RT-PCR. Among them, CD52, the lymphocyte surface marker, could be a target molecule to overcome bortezomib resistance. CD52 gene expression was examined in 6 different MM cell lines. Its expression was detected in U266, ARH77, and HS-sultan, but not in RPMI8226, IM9 and 536MM. The expression level of CD52 was correlated to the response of Bortezomib sensitivity. FASC analysis showed that CD52+ populations in U266/velR were 2.7 fold higher than those in control. When U266 cells were serially treated with Bortezomib, CD52 expression was gradually increased. In transfection analysis using full length cDNA of CD52 gene, transfected RPMI8226 cells were more resistant than parental cell. Our results suggested that Alemtuzumab was proposed as a therapeutic agent in bortezomib resistant myeloma patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1543.
The Age of Miracles: Medicine and Surgery In the Nineteenth Century
Authors: William G. Abel
Journal: JAMA (1988)

Guy Williams in<i>The Age of Miracles</i>has crafted a fascinating account of major advances and discoveries in the 19th century that have profoundly affected current health care. The book begins with a well-known figure, the anatomist John Hunter, and the contributions of some of his famous pupils, such as Edward Jenner and his monumental work on smallpox. The difficulties of investigation and teaching are highlighted by accounts of the "body snatchers" who provided material for dissection culminating in the Anatomy Act of 1832, which ensured a "sufficient supply of cadavers" in Britain. The chapter on anesthetics is pleasantly thorough and details all the important events connected with this remarkable discovery that freed human beings from the agonies of surgery. "Going to hospital" in the early 19th century was a decision not taken lightly and generally was avoided at all costs by those who could be operated on and otherwise
Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A
Authors: Johnny Mahlangu, Jerry S. Powell, Margaret V. Ragni, Pratima Chowdary, Neil C. Josephson, Ingrid Pabinger, Hideji Hanabusa, Naresh Gupta, Roshni Kulkarni, Patrick Fogarty, David Perry, Amy Shapiro, K. John Pasi, Shashikant Apte, Ivan Nestorov, Haiyan Jiang, Shuanglian Li, Srividya Neelakantan, Lynda M. Cristiano, Jaya Goyal, Jurg M. Sommer, Jennifer A. Dumont, Nigel Dodd, Karen Nugent, Gloria Vigliani, Alvin Luk, Aoife Brennan, Glenn F. Pierce
Journal: Blood (2013)
INFERIORITY FEELINGS AND HOSTILITY
Authors: LEON J. SAUL
Journal: American Journal of Psychiatry (1951)

Feelings of inferiority generally stem from warping and impairment of the emotional development, which result from various abuses in the rearing of children. The feeling of inferiority, which may or may not be fully conscious, is reacted against in a number of ways, of which three are of particular importance; overcompensatory egotism, power-seeking, and hostility. We live in a world in which feelings of inferiority are widespread. This betokens a widespread amount of emotional crippling. Emotional cripples, reacting against their feelings of inferiority with exaggerated egotism, power-seeking and hostility, should be recognized as such, for they play an important part in creating the problems of the world, between nations, within nations, and even in small groups.
The last (k) night
Authors: L. Farrell
Journal: BMJ (1995)

There they stood, ranged along the hillsides, met To view the last of me. A living frame For one more picture! in a sheet of flame I saw them and I knew them all. And yet Dauntless the slug-horn to my lips I set, And blew. “Childe Roland to the Dark Tower came.”—ROBERT BROWNING

The old man signed his name and laid down his pen with a weary hand. He sighed heavily; his will and testament had not taken long to write. His possessions were few—worthless heirlooms, faded gowns, and dusty scrolls from older days. He had no family to treasure them, no acolytes to venerate them.

From outside the shuttered windows came the sounds of everyday life …
The Role of Antibiotics in the Treatment of Chronic Prostatitis:A Consensus Statement
Authors: T.E. Bjerklund Johansen, R.N. Gr&uuml;neberg, J. Guibert, A. Hofstetter, B. Lobel, K.G. Naber, J. Palou Redorta, P.J. van Cangh
Journal: European Urology (1998)
Unusual Site of Metastasis Detected With FDG PET/CT in a Case of Recurrent Rectosigmoid Cancer
Authors: Rong-Hsin Yang, Yum-Kung Chu, Wing-Yin Li
Journal: Clinical Nuclear Medicine (2013)

Metastatic colon cancers to the oral cavity are unusual, involving a majority of the mandible rather than the oral soft tissues. We describe a rare site of gingival metastasis in a case of rectosigmoid cancer. The patient was a 74-year-old woman who developed swelling and persistent bleeding of the right mandibular gingiva after tooth extraction. A PET/CT using 18F-FDG depicted multiple metastatic lesions in the neck, lung, abdominal wall, and mandibular gingiva. Histologic study of the gingival lesion confirmed the diagnosis of gingival metastasis from colon adenocarcinoma.
Broca and Bouillaud-Reply
Authors: Byron Stookey
Journal: JAMA (1963)

Instances of inability to speak were known to Hippocrates and to Aristotle, and for centuries before them. Jean-Baptiste Bouillaud was, however, the first to analyze speech disorder and to recognize its various mechanisms. He held that the faculty to create and articulate words, and to indicate and retain the memory of ideas, required a special center. Bouillaud described patients who, though unable to speak, were able to write, proving that their intelligence was unimpaired; he noted that other patients expressed themselves by signs, conveying their ideas with their hands, their eyes, and their facial expression. He placed the center controlling speech in the frontal lobes. His contributions from 1825 to 1848, and again in the 1860's, have not received their deserved recognition. As early as 1839 Bouillaud said he "had not dared to determine the precise point, the precise mathematical region, in the frontal lobes as the seat of speech..."
Demonstration of a widely distributed atrial pacemaker complex in the human heart.
Authors: J P Boineau, T E Canavan, R B Schuessler, M E Cain, P B Corr, J L Cox
Journal: Circulation (1988)

Atrial depolarization was analyzed in 14 patients with the Wolff-Parkinson-White syndrome undergoing surgery to ablate accessory atrioventricular pathways associated with tachyarrhythmias. Bipolar potentials were recorded simultaneously from 156 atrial epicardial electrodes arranged in three templates to fit the anterior and posterior aspects of both atria. Spontaneous or sinus rhythms were recorded, as were atrial escape rhythms after overdrive pacing at rates of 150 and 200 beats/min. Atrial activation maps revealed different patterns of impulse initiation varying from typical unifocal sinus node impulse origin, unifocal extranodal impulse origin, and multicentric impulse origin from two to four widely distributed atrial pacemaker sites. In subjects demonstrating only unifocal impulse origin during control or sinus rhythm, other widely divergent pacemaker sites were recorded in other maps during subsequent rhythms. In addition to sites located at the upper superior vena cava-right atrium junction, pacemakers also dominated at sites anterior and inferior to the sinus node region during both control and escape depolarizations. Most of the subjects were found to have two or more pacemaker sites when maps of all control and postpacing conditions were analyzed. The right atrial pacemaker region encompassed a zone of 7.5 X 1.5 cm centered about the long axis of the sulcus terminalis posteriorly and the precaval band anteriorly. An unexpected finding was the participation of left atrial escape pacemakers. The functional behavior of both the control and escape pacemakers, as assessed by sinus node recovery time, was normal, indicating physiologic operation of the extranodal sites as part of an overall system of distributed pacemakers involved in the control of rate. Although functional assessment was limited in these initial patient studies, correspondence with similar observations in extensive previous canine studies supports the concept of a widely distributed atrial pacemaker complex in man.
Endocrine Control of Blood Sugar, Lipaemia, and Ketonaemia in Diabetic Baboons
Authors: J. Gillman, C. Gilbert, E. Epstein, J. C. Allan
Journal: BMJ (1958)

Complete removal of the pancreas from normal baboons, as in other mammals, leads to the development of the classical features of diabetes, including hyperglycaemia, ketonaemia and ketonuria, polydipsia, and polyuria.Investigation of the diabetic state in experimental baboons revealed that the severity of the ketosis could not be correlated with the degree of hyperlipaemia or with the hyperglycaemia, and that the extent of the hyperglycaemia did not influence the hyperlipaemia (Gillman et al., 1958a).On the basis of experiments conducted in dogs, cats, and rats, it is generally believed that the fundamental disorder of carbohydrate meta- bolism in diabetic animals is alleviated by hypophysec- tomy, or by adrenalectomy, and that the administration of pituitary extracts and of adrenocortical hormones will once again restore the diabetic picture in depan- creatized-hypophysectomized and in depancreatized- adrenalectomized animals respectively (Houssay and Biasotti, 1931;and Long and Lukens, 1936).Reinvestigation of the role of the hypophysis and of the adrenal in depancreatized baboons not receiving insulin will show that the severity of the diabetes, as assessed by the hyperglycaemia and glycosuria, is not immediately alleviated by hypophysectomy although the clinical condition of the baboon is improved.It will also become apparent from the data presented below, taken in conjunction with previously reported experi- ments (Gillman et al., 1958a), that each aspect of the disorder of lipid metabolism is dependent upon a parti- cular pattern of endocrine function.It is suggested that analysis of the various lipid fractions in the blood as well as of the blood sugar and blood ketones in each human diabetic may afford a useful guide to the relative participation of the endocrine glands in maintaining the disorder of metabolism.
NHS trust plans to cut consultant posts to make savings
Authors: Owen Dyer
Journal: BMJ (2005)

An NHS trust in England has announced that it will cut consultant and house officer posts next year. The trust is being asked to make savings to make up for budget overspends by other trusts. A survey of medical directors has warned that similar cuts may be made elsewhere ( BMJ 2005;331: 716, 1 Oct).

Oxfordshire Mental Healthcare Trust …
What to Do about Esophageal Varices?
Authors: Telfer B. Reynolds
Journal: New England Journal of Medicine (1983)

In this issue of the Journal, Burroughs and colleagues report the results of a two-year randomized controlled trial of propranolol therapy to prevent recurrent bleeding from esophageal varices.1 There was no reduction in the frequency of bleeding from either varices or mucosal erosions despite a substantial reduction in wedged hepatic-vein pressure.These results are disappointing, to say the least. Compliance by the patients taking propranolol was good, judging from decreases in pulse rate, though it seems possible that the alcoholic patients who had resumed drinking were not taking their medication at the time of the bleeding episodes. Forty-eight patients . . .
IMPROVISED RUBBER CORK — FOUNTAIN SYRINGE
Authors: O. M. Rhodes
Journal: JAMA (1923)

Not infrequently one has need or desire for a rubber cork, and almost as frequently is unable to find one of suitable size or condition about his office or in the drug store. This need caused me to improvise this suitable article: Over an ordinary cork, a little smaller than the bottle one wishes to fit, is slipped a piece of rubber tubing up over it so as to fit tightly. The tubing is then cut off about one-eighth inch below the bottom end of the cork. The space thus formed is filled with melted paraffin, and thus a very satisfactory substitute is quickly obtained. <h3>FOUNTAIN SYRINGE</h3> When one has use for a fountain syringe and there is none in the home, or if there is one it is found to be out of repair when wanted, a substitute may be made by having the tinner solder two one-fourth inch
Evidence of deteriorating semen quality in the United Kingdom: birth cohort study in 577 men in Scotland over 11 years
Authors: S. Irvine, E. Cawood, D. Richardson, E. MacDonald, J. Aitken
Journal: BMJ (1996)

To determine whether the quality of semen has changed in a group of over 500 Scottish men born between 1951 and 1973.Retrospective review of data on semen quality collected in a single laboratory over 11 years and according to World Health Organisation guidelines.Programme of gamete biology research funded by Medical Research Council.577 volunteer semen donors. Of these, 171 were born before 1959, 120 were born in 1960-4, 171 in 1965-9, and 115 in 1970-4.Conventional criteria of semen quality including semen volume (ml), sperm concentration (10(6)/ml), overall motility (% motile), total number of sperm in the ejaculate (10(6)), and total number of motile sperm in the ejaculate (10(6)).When the four birth cohort groups were compared a later year of birth was associated with a lower sperm concentration, a lower total number of sperm in the ejaculate, and a lower number of motile sperm in the ejaculate. The median sperm concentration fell from 98x10(6)/ml among donors born before 1959 to 78x10(6)/ml among donors born after 1970 (P=0.002). The total number of sperm in the ejaculate fell from 301x10(6) to 214x10(6) (P=0.0005), and the total number of motile sperm in the ejaculate fell from 169.7x10(6) to 129.0x10(6) (P=0.0065).This study provides direct evidence that semen quality is deteriorating, with a later year of birth being significantly associated with a reduced number of sperm in adult life.
Coronary-Stent Fracture
Authors: Pertha S Chowdhury, Renato G Ramos
Journal: New England Journal of Medicine (2002)

Figure 1. A 57-year-old man presented with several hours of chest discomfort accompanied by ischemic changes on his electrocardiogram. He had undergone coronary-artery bypass grafting and subsequent percutaneous coronary intervention one year earlier, with deployment of a stent in the saphenous-vein graft to the first obtuse marginal artery. Cardiac angiography showed severe three-vessel disease of the native coronary arteries, a patent graft involving the left internal thoracic artery and the left anterior descending coronary artery, a previously identified occluded vein graft anastomosed to the right coronary artery, and a newly occluded vein graft anastomosed to the first obtuse marginal artery. . . .
CONCURRENT HYDROPERICARDIUM AND PNEUMOTHORAX
Authors: Harold H. Fox
Journal: JAMA (1924)

A review of the literature on pericarditis with effusion, and on pneumothorax, fails to disclose a report of exactly the combination of pathologic conditions reported here. The extreme rarity of this condition and the good results following surgical treatment under local anesthesia warrant the report of the case. <h3>REPORT OF CASE</h3> W. P. R., a man, aged 36, married, at the age of 19 first noticed a "slipping, rubbing sensation" in the chest, so severe as to awaken him at night. It was apparently caused by the beating of his heart. He was told by a physician that this condition was caused by the heart, and that one of the heart valves was leaking. Several years later this condition cleared up, and he did not notice it again until his present illness. July 25, 1922, while dressing, the patient first noticed that his heart was beating on the right side,
Documenta Geigy. Rheumatoid Arthritis: Organ Manifestations and Complications
Authors: A. Nicholls
Journal: Annals of the Rheumatic Diseases (1981)

a result suggesting that these cells are sensitised with rheumatoid and psoriatic arthritis.Numerous remarkable autoantibodies of IgE class.The implication is that Type photographs of crystals of sodium urate, calcium salts,
Spontaneous Retroperitoneal Hemorrhage Localized by Blood Pool Scintigraphy
Authors: Daniel B. Lerer, Alla M. Rozenblit, Jacob Cynamon, Gary Tubman, Leonard M. Freeman
Journal: Clinical Nuclear Medicine (2004)

A healthy 17-year-old girl presented to the emergency department with a 1-day history of left upper quadrant abdominal pain associated with nausea and vomiting. Her hematocrit was 22. On physical examination, she had left upper quadrant fullness and tenderness. Initial computed tomography revealed a large, loculated, left-sided retroperitoneal hematoma. Blood pool scintigraphy with labeled red cells revealed a very large photon-deficient area with 3 areas of active bleeding in the upper margin of the cold area. An angiogram showed active extravasation from the left inferior phrenic artery. The patient was felt to have had spontaneous adrenal hemorrhage, likely within a preexisting, large adrenal cyst. Spontaneous hemorrhage into an adrenal cyst is a rare entity that can be life-threatening if not treated early in its course.
<i>AKT1</i> Amplification Regulates Cisplatin Resistance in Human Lung Cancer Cells through the Mammalian Target of Rapamycin/p70S6K1 Pathway
Authors: Ling-Zhi Liu, Xiang-Dong Zhou, Guisheng Qian, Xianglin Shi, Jing Fang, Bing-Hua Jiang
Journal: Cancer Research (2007)

Abstract Cisplatin [cis-diaminodichloroplatinum (II) (CDDP)] is one of the most widely used and effective therapeutic agents for many kinds of cancers. However, its efficiency is limited due to development of drug resistance. In this study, we showed that CDDP resistance was associated with AKT1 overexpression and gene amplification in human lung cancer cells that acquired the drug resistance. We showed that AKT1 forced expression in the cells was sufficient to render the cells CDDP resistant, and that AKT1 inhibition by its dominant negative mutant reversed the CDDP-resistant cells to be CDDP sensitive. These results show that AKT1 activity is essential for regulating CDDP resistance in cultured lung cancer cells. To study whether these results were correlated with human lung cancer tumors, we randomly selected tumor samples from human lung cancer patients to study the correlation of AKT activation and CDDP resistance in clinical tumor samples. We showed that AKT activation was highly related to CDDP chemosensitivity in human tumor tissues. Our results further showed that AKT1 induced lung cancer cells to become resistant to CDDP through the mammalian target of the rapamycin (mTOR) signaling pathway. These studies conclude that AKT amplification and the mTOR pathway play an important role in human lung cancer cells acquiring CDDP resistance, which represents a new mechanism for acquiring CDDP resistance and a potential novel therapeutic target for overcoming CDDP resistance in human cancer in the future. [Cancer Res 2007;67(13):6325–32]
Unilateral Radioiodine Breast Uptake
Authors: SIEMA M.B. BAKHEET, JOHN POWE, MUHAMMAD M. HAMMAMI
Journal: Clinical Nuclear Medicine (1998)

Presented is a case of unilateral breast uptake on radioiodine whole body scan of a woman with thyroid cancer. Significant uptake in the right breast mimicked pulmonary metastases. The left breast was not visualized. The patient had ceased breast-feeding from the right breast 4 weeks prior to the scan, and had not breast-fed from the left breast because of a painful skin ulcer. In order to prevent unnecessary radiation exposure to a nursing infant or mother, females of reproductive age preparing to have radioiodine scans should be questioned routinely about current or previous breast-feeding and about galactorrhea. Also, because radioiodine breast uptake could mimic or compete with thyroid cancer uptake, this is important information to have in order to correctly interpret the scans.
Apoptosis and complement-mediated lysis of myeloma cells by polyclonal rabbit antithymocyte globulin
Authors: Martin S. Zand, Thuong Vo, Tina Pellegrin, Raymond Felgar, Jane L. Liesveld, Jainulabdeen J. Ifthikharuddin, Camille N. Abboud, Ignacio Sanz, Jennifer Huggins
Journal: Blood (2005)