tbuckley/cabot-search huggingface dataset:
Circulating levels of brain‐derived neurotrophic factor correlate with disease severity in the intrinsic type of atopic dermatitis
Authors: U. Raap, T. Werfel, C. Goltz, N. Deneka, K. Langer, M. Bruder, A. Kapp, G. Schmid‐Ott, B. Wedi
Journal: Allergy (2006)

Background: Recent studies have shed light on the complex regulation of genetic, environmental, immunologic and pharmacologic factors, which contribute to the development of atopic dermatitis (AD). However, it is still unclear to which extent neuroimmune mediators have a role in AD. Aims of the study: To assess peripheral neurotrophin levels and their correlation with scoring atopic dermatitis (SCORAD) scores in both the intrinsic and extrinsic types of AD compared with patients with psoriasis and nonatopic healthy subjects. Methods: Levels of brain‐derived neurotrophic factor (BDNF) and nerve growth factor (NGF) were assessed in peripheral blood with enzyme‐linked immunosorbent assay. Based on IgE‐mediated sensitization, AD was divided into the extrinsic and intrinsic type. Severity of AD was assessed with SCORAD score and with psoriasis area and severity index (PASI) in patients with psoriasis. Results: Brain‐derived neurotrophic factor and NGF were detectable in all the subjects studied. However, the levels of both neurotrophins were significantly higher in patients with extrinsic and intrinsic types of AD compared with patients with psoriasis and nonatopic healthy subjects (NGF: P &lt; 0.001, BDNF: P &lt; 0.001). NGF and BDNF levels were similar in the intrinsic and extrinsic type of AD. There was a significant correlation between BDNF and SCORAD score only in patients with the intrinsic type of AD ( r = 0.57, P &lt; 0.05). Conclusions: This study shows for the first time that NGF and BDNF are increased in both, the extrinsic type and the intrinsic type of AD. This finding points to a similar pathophysiologic background implicating a neuroimmune network in both variants of this chronic inflammatory skin disease. Future studies are needed to show the direct mechanisms of neurotrophin action in chronic inflammatory skin.
“idiopathic thrombocytopenic purpura‐like syndrome” treated with interferon in a patient with lung cancer
Authors: B. L. Rapoport, G. Falkson, A. S. Alberts, P. Eloff
Journal: American Journal of Hematology (1990)

Abstract A case of autoimmune thrombocytopenia associated with lung cancer is presented. The thrombocytopenia occurred 2 years before the diagnosis of lung cancer. Previous treatments include high doses of corticosteroids and splenectomy. The patient was managed with interferon, which resulted in an increase of the platelet count with control of the hemorrhagic manifestations with this syndrome.
Germany's drug regulatory body is attacked
Authors: Annette Tuffs
Journal: BMJ (2006)

The independent institute that assesses new drugs in Germany is facing criticisms similar to those aimed at its equivalent body in the United Kingdom, the National Institute for Health and Clinical Excellence. 

Last week in Cologne a member of an association for people with diabetes and representatives of the drug industry walked out of a hearing of the Institute for Quality and Economic Efficiency in Health Care in Cologne because they were not allowed to record the hearing, which was on the use of short acting insulin analogues. 

The institute has provoked anger among patients' groups and the drug industry by saying that no evidence has been …
Somatostatin plus isosorbide 5-mononitrate versus somatostatin in the control of acute gastro-oesophageal variceal bleeding: a double blind, randomised, placebo controlled clinical trial
Authors: F Junquera
Journal: Gut (2000)

<h3>BACKGROUND</h3> Variceal bleeding is a severe complication of portal hypertension. Somatostatin reduces portal pressure by decreasing splanchnic blood flow, and nitrates by diminishing intrahepatic resistance. Experimental studies have shown that the combination of somatostatin and nitrates has an additive effect in decreasing portal pressure. <h3>AIM</h3> To compare the therapeutic efficacy of either intravenous infusion of somatostatin plus oral isosorbide 5-mononitrate or somatostatin alone in gastro-oesophageal variceal bleeding associated with liver cirrhosis. <h3>METHODS</h3> A unicentre, double blind, placebo controlled, clinical trial was conducted. Sixty patients bleeding from oesophageal or gastric varices were randomised to receive intravenous infusion of somatostatin (250 μg/hour) plus oral isosorbide 5-mononitrate (40 mg/12 hours) (group I) or somatostatin infusion plus placebo (group II) for 72 hours. <h3>RESULTS</h3> The two groups of patients had similar clinical, endoscopic, and haematological characteristics. Control of bleeding was achieved in 18 out of 30 patients (60%) in group I and 26 out of 30 patients (87%) in group II (p&lt;0.05). There was no significant difference in mean transfusion requirements between the two groups: 2.6 (2.2)<i>v</i> 1.8 (1.6) respectively; means (SD). Mortality and side effects were similar in the two groups, but development of ascites was higher in group I (30%) than in group II (7%) (p&lt;0.05). <h3>CONCLUSION</h3> In cirrhotic patients with acute gastro-oesophageal variceal bleeding, addition of isosorbide 5-mononitrate to somatostatin does not improve therapeutic efficacy, induces more adverse effects, and should not be used.
Verification Bias and the Prostate-Specific Antigen Test — Is There a Case for a Lower Threshold for Biopsy?
Authors: Fritz H. Schröder, Ries Kranse
Journal: New England Journal of Medicine (2003)

Verification bias can influence the interpretation of the most important screening test for prostate cancer, measurement of prostate-specific antigen (PSA). Such bias arises when the presence or absence of prostate cancer has not been verified by prostate biopsy in all subjects in the screened population. In this issue of the Journal, Punglia et al. report on how verification bias alters the sensitivity and specificity of the PSA test, and how this bias can influence the clinical decision about whether to perform a biopsy of the prostate.1 The problem has been recognized previously,2,3 but Punglia et al. address it with . . .
Naevus spilus: a light and electron microscopical study
Authors: R.A.J. Eady, T.C. Cowen
Journal: British Journal of Dermatology (1975)

Journal Article Naevus spilus: a light and electron microscopical study Get access R.A.J. Eady, R.A.J. Eady Institute of Dermatology, Homerton Grove, London Search for other works by this author on: Oxford Academic Google Scholar T.C. Cowen T.C. Cowen Institute of Dermatology, Homerton Grove, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 93, Issue s11, 1 July 1975, Page 16, https://doi.org/10.1111/j.1365-2133.1975.tb06764.x Published: 01 July 1975
Mechanical strain increases cytokine and chemokine production in bronchial fibroblasts from asthmatic patients
Authors: F. Le Bellego, H. Perera, S. Plante, J. Chakir, Q. Hamid, M. S. Ludwig
Journal: Allergy (2008)

Mechanical strain and cytokine stimulation are two important mechanisms leading to airway remodeling in asthma. The effect of mechanical strain on cytokine secretion in airway fibroblasts is not known. The aim of this study was to determine whether bronchial and nasal fibroblasts differentially alter cytokine secretion in response to mechanical strain.We measured secretion of the pro-fibrotic cytokine, interleukin-6 (IL-6), and the pro-inflammatory cytokines, IL-8 and monocyte chemotactic protein 1, before and after mechanical strain in bronchial fibroblasts obtained from asthmatic patients [asthmatic bronchial fibroblasts (BAF)] and normal volunteers [normal bronchial fibroblasts (BNF)], and in nasal fibroblasts (NF) obtained from nasal polyps. Cells were grown on flexible membranes and a mechanical strain of 30% amplitude, 1 Hz frequency was applied for 3, 6 and 24 h. Control cells were unstrained. IL-6, IL-8 and monocyte chemotactic protein 1 was measured after 24 h strain using enzyme-linked immunoassay; mRNA was measured by real time polymerase chain reaction. We also measured mRNA for versican, a matrix proteoglycan, known to be upregulated in the asthmatic airway wall.In unstrained conditions, no differences in cytokine secretion were observed. After 24 h strain, BAF secreted more IL-6 than BNF. Mechanical strain increased IL-8 mRNA in BAF, BNF and NF; and IL-6 and versican mRNA, in BAF, only.Cytokine responses to mechanical strain varied in different airway fibroblast populations, and depended on the site of origin, and the underlying inflammatory state. Strain resulted in IL-6 upregulation and increased message for extracellular matrix protein in bronchial fibroblasts from asthmatic patients only, and may reflect these patients' propensity for airway remodeling.
Heterodimerization of FGF-receptor 1 and PDGF-receptor-α: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells
Authors: Debora Faraone, Maria S. Aguzzi, Gianluca Ragone, Katia Russo, Maurizio C. Capogrossi, Antonio Facchiano
Journal: Blood (2005)
Eric Ronald Down
Authors: D. Kalra
Journal: BMJ (2003)

General practitioner Northwich, Cheshire, 1983-2003 (b Dulwich, London, 1952; q Manchester 1976), died from pulmonary embolus on 24 February 2003.

Eric came from humble beginnings in London to gain entry to medical school. He joined the Royal Air Force as an undergraduate and after qualification served five years as a medical officer at various airbases in England. He left the air force as a squadron leader and entered general practice in Cheshire. Eric was naturally gregarious and had a memorable and infectious laugh. In his latter years he was troubled by bouts of increasingly resistant depression, limiting his ability to work. He leaves a wife, Elizabeth, and two daughters.
Emergency radiography of the ankle
Authors: A M T Good
Journal: BMJ (1994)

and especially in KwaZulu, the Zulu homeland, we have an extreme shortage of medical staff.The KwaZulu Department of Health has divided itself into six regions, each of which contains about five wards centred on their own hospital.Specialists are based at the regional hospitals but are encouraged to visit the ward hospitals for teaching and to provide services.The ward hospitals are rural.Around each ward hospital is a network of residen- tial clinics staffed by nurses trained in primary health care.Patients with conditions beyond the nurses' competence are referred to the ward hos- pital for care.Rural hospitals are therefore very much part of the community, and a good rural physician can have considerable contact with the local people.Because the rural hospitals are up to 200 km
TWO-YEAR SAFETY AND EFFICACY OF DURABLE POLYMER SECOND-GENERATION DRUG-ELUTING STENT VERSUS BIODEGRADABLE POLYMER DRUG-ELUTING STENT IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION: DATA FROM KOREA ACUTE MYOCARDIAL INFARCTION REGISTRY (KAMIR)
Authors: In-Cheol Kim, Seung-Ho Hur, Yun-Kyeong Cho, Hyuck-Jun Yoon, Chang-Wook Nam, Kwon-Bae Kim, Min-Seok Kim, Jin-Cheol Park, Young-Jo Kim, Chong-Jin Kim, Myeong-Chan Cho, Myung-Ho Jeong
Journal: Journal of the American College of Cardiology (2015)
Combination Estrogen–Progestin Oral Contraceptives
Authors: Diana B. Petitti
Journal: New England Journal of Medicine (2003)

A healthy, sexually active, 35-year-old woman presents for advice about the use of oral contraceptives. She does not smoke cigarettes and has no personal or family history of venous thromboembolism, myocardial infarction, or stroke. Her blood pressure is 120/80 mm Hg. Should an oral contraceptive be prescribed, and if so, how should a formulation be chosen?
Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas
Authors: Eugenio Gaudio, Francesco Paduano, Apollinaire Ngankeu, Francesca Lovat, Muller Fabbri, Hui-Lung Sun, Pierluigi Gasparini, Alexey Efanov, Yong Peng, Nicola Zanesi, Mohammed A. Shuaib, Laura Z. Rassenti, Thomas J. Kipps, Chenglong Li, Rami I. Aqeilan, Gregory B. Lesinski, Francesco Trapasso, Carlo M. Croce
Journal: Blood (2012)
Pretransplant renal function predicts survival in patients undergoing orthotopic liver transplantation
Authors: Satheesh Nair, Sumita Verma, Paul J. Thuluvath
Journal: Hepatology (2002)

The objective of this study was to determine the impact of pretransplant renal function on graft and patient survival rates after orthotopic liver transplantation (OLT) using the United Network for Organ Sharing (UNOS) database for adults who underwent OLT between 1988 and 1996. Based on calculated creatinine clearance (CCr) at the time of OLT, patients were classified arbitrarily into those with normal renal function (>70 mL/min) and mild (40-69.9 mL/min), moderate (20-39.9 mL/min), and severe (<20 mL/min) renal insufficiency. Of the 20,281 patients who underwent transplantation, complete data were available for 19,261 patients. Of these, 12,778 (67%) had normal CCr (mean, 118 +/- 50 mL/min) and 4,419 (22%) had mild (56 +/- 8.5 mL/min), 1,560 (8%) had moderate (30 +/- 5.7 mL/min), and 504 (3%) had severe (14 +/- 3.6 mL/min) renal failure. UNOS status 1 was more common in patients with moderate and severe renal failure. Primary graft nonfunction and 30-day mortality rates were higher and 1-, 2-, and 5-year graft and patient survival rates were lower in patients with moderate or severe renal failure. Multiple regression analysis showed that renal failure was an independent predictor of 30-day and 2-year mortality after adjusting for the recipient's age, sex, etiology of liver disease, diabetes status, body mass index, cold ischemic time, and UNOS status. CCr less than 40 mL/min was associated with significantly lower short-term and long-term graft and patient survival rates. In conclusion, our findings suggest that when Mayo End-Stage Liver Disease (MELD) score is used to prioritize organ allocation, lower-than-expected graft and patient survival rates may be seen.
Aggressive Treatment for the Fit Elderly With Non–Small-Cell Lung Cancer? Yes!
Authors: Lecia V. Sequist, Thomas J. Lynch
Journal: Journal of Clinical Oncology (2003)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.04.002 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12874267 Aggressive Treatment for the Fit Elderly With Non–Small-Cell Lung Cancer? Yes! Lecia V. SequistxLecia V. SequistSearch for articles by this author , Thomas J. LynchxThomas J. LynchSearch for articles by this author Show More Massachusetts General Hospital Cancer Center, Dana-Farber/Partners Cancer Care, Harvard Medical School, Boston, MA https://doi.org/10.1200/JCO.2003.04.002 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
In Cauda Venenum
Authors: J.H. van Birgelen
Journal: Psychotherapy and Psychosomatics (1981)

Meeting Reports/Abstracts| February 16 2010 In Cauda Venenum Subject Area: Psychiatry and Psychology J.H. van Birgelen J.H. van Birgelen Ziekenhuis Leyenburg, The Hague, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1981) 35 (4): 217. https://doi.org/10.1159/000287498 Article history Published Online: February 16 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation J.H. van Birgelen; In Cauda Venenum. Psychother Psychosom 1 April 1981; 35 (4): 217. https://doi.org/10.1159/000287498 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1981Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
The grass isn't always greener
Authors: Hugh Seeley
Journal: Journal of the Royal Society of Medicine (2012)

How refreshing it was to read Bryson's article which reminded us of the ethical foundations of the NHS and of what it achieves with comparatively modest expenditure.

The debates which preceded President Obama's reforms of American healthcare were often ill-informed and frequently ugly. Senator Grassley's statement, which Bryson quotes, was typical. I was in Washington DC in 2009, one month after Professor Stephen Hawking had received the Presidential Medal of Freedom. During a TV discussion, one contributor stated, in all seriousness, that ‘if Stephen Hawking lived in England and had to rely on British socialized medicine, he would not be alive today’.
A comparison of follow-up regimes in rheumatoid arthritis.
Authors: A G Mowat, P J Nichols, E M Hollings, R J Haworth, L C Aitken
Journal: Annals of the Rheumatic Diseases (1980)

One hundred and thirty-two patients discharged from a rheumatology unit were randomly allocated to general practitioner care, attendance at hospital outpatient clinics, or follow-up by a senior occupational therapist attached to the hospital treatment team. At the end of 1 and 2 years a number of clinical and functional tests were applied, and information was gathered about the provision and use of aids and the provision of domestic support. In addition the standard of overall care was judged by an independent assessor. Although no significant intergroup differences in disease activity or function emerged, it is clear that patients prefer continuing contact with the hospital team, and this may lead to differences appearing in the future. The financial advantages of therapist follow-up are discussed.
Influence of bolus temperature on human esophageal motor function
Authors: D. H. Winship, S. R. Viegas De Andrade, F. F. Zboralske
Journal: Journal of Clinical Investigation (1970)

Hot and cold water, in comparison to room temperature water, ingested by normal young men, profoundly alters esophageal motor function. Cold water slows or abolishes esophageal peristalsis, prolongs the contraction wave in the distal esophagus, produces a delayed but prolonged relaxation of the lower esophageal sphincter, and regularly causes a lower esophageal sphincteric contraction of increased amplitude. It does not, however, diminish the frequency of response of the lower esophageal sphincter even when the peristaltic wave above is abolished. Hot water, on the other hand, accelerates the response of the esophagus to the swallow; this change is reflected by increased speed of wave propagation, waves of shorter duration, a more brief relaxation of the lower esophageal sphincter, and a lower esophageal sphincter contraction of less amplitude. Hot water may even increase the frequency of peristalsis at least in the proximal esophagus. In spite of these changes, however, neither extreme of temperature altered the rapid passage of the water swallows through the more proximal portions of the esophagus. Hot water tended to traverse the lower esophageal sphincter more rapidly than did room temperature water, but cold water was often delayed in entering the stomach and tended to pool in the distal esophagus even though sphincteric relaxation was manometrically complete and prolonged.
A System of Complete Medical Police: Selections From Johann Peter Frank
Authors: Lester S. King
Journal: JAMA (1976)

Johann Peter Frank (1735-1821) was one of the great pioneers of public health as well as of what we now call social medicine. His great contribution was a mammoth work of six volumes, the first of which was published in 1779, the fourth in 1788, and the last two volumes appearing in 1812 and 1817-1819, respectively. The title is misleading to the modern reader, for the word "police" meant the science of administering the state, and medical police concerns the relationships of the state to health problems. It involves a patriarchal or paternalistic attitude closely akin to the welfare state of today. Frank covered more or less systematically various aspects of hygiene and public health as well as selected aspects of medicine. He gave vivid descriptions of the conditions at the time and of the great need for reform and regulation if the people were to achieve a healthy status.
1161 A PROSPECTIVE STUDY OF ACETAMINOPHEN THERAPEUTIC MISADVENTURE: DURATION OF INTAKE AND HEAVY DRINKING ARE TWO KEY FACTORS
Authors: F. Wartel, A. Louvet, S. Dharancy, H. Castel, B. Quesnel, E. Parmentier, V. Canva, P. Deltenre, P. Mathurin
Journal: Journal of Hepatology (2010)
Work of the Full-Time Instructor
Authors: Henry Leffmann
Journal: JAMA (1913)

To the Editor:  —When a standard is established in food or drug analysis, a method of approximation to the standard is also established. Thus, if a sanitary authority fixes a limit of 25 parts per million for sulphur dioxid in gelatin, it also sets forth in detail the process by which the ingredient is to be determined.  I make this prologue because I wish to call attention to the fact that while severe standards are now being required for medical colleges, no definite methods of ascertaining compliance therewith are being furnished, nor, as it seems to me, are some of the standards clearly defined.  Take, for example, the full-time instructors. What constitutes full time? Surely, it is not meant that the instructor is to spend all his, or her, waking hours in the teaching work. It is thought by many that research work should be performed by such teachers in