tbuckley/cabot-search huggingface dataset:
Hazards of hyposplenism.
Authors: A Ferguson
Journal: BMJ (1982)

irreversible brain damage, let us not prolong the dying once the criteria for brain death has been established.Because ofnot despite-their grief, the next of kin of a younger patient should be given the opportunity of offering certainly the kidneys and possibly the heart for the relief of another patient who may have suffered long.In Britain sound, unhurried clinical judgment (supported when necessary by other special- ists), sympathy, understanding, and mutual trust, rather than abstract principles and printed policy statements, have in general stood patients in good stead.
Congenital cutis laxa with a dominant inheritance and early onset emphysema.
Authors: E Corbett, H Glaisyer, C Chan, B Madden, A Khaghani, M Yacoub
Journal: Thorax (1994)

Two cases (mother and daughter) are reported of autosomal dominant cutis laxa which are unusual in being associated with early onset emphysema. Both mother and daughter have been smokers and are heterozygotes for the alpha 1 antitrypsin genotype. The combination of cigarette smoking and subnormal alpha 1 antitrypsin levels may explain the pulmonary spread in these two women who have what is usually a benign form of cutis laxa limited to the skin.
Exercise-Induced Anaphylactic Syndromes
Authors: Thomas B. Casale
Journal: JAMA (1986)

To differentiate the diagnoses of exercise-induced anaphylaxis and cholinergic urticaria anaphylaxis, we developed reproducible diagnostic provocative challenges. The data derived from the study of two representative patients, one with cholinergic urticaria and the other with exercise-induced anaphylaxis, suggest approaches to distinguishing these diagnoses. After specific exercise challenges, both patients developed symptoms consistent with anaphylaxis and had associated increases in plasma histamine levels. After passive heat challenges inducing increases in core body temperature more than 0.7 °C, only the patient with cholinergic urticaria developed anaphylactic symptoms and had a rise in the plasma histamine level. Neither patient developed symptoms of anaphylaxis when core body temperatures were increased after administration of intravenous endotoxin. Thus, passive heat challenges are extremely valuable in differentiating these two exercise-related syndromes. Although not important in exercise-induced anaphylaxis, specific thermoregulatory mechanisms appear to play an intricate part in the pathophysiology of cholinergic urticaria /anaphylaxis. (<i>JAMA</i>1986;255:2049-2053)
Association of systemic lupus erythematosus and hypermobility
Authors: M Guma
Journal: Annals of the Rheumatic Diseases (2002)

To investigate joint laxity in patients with systemic lupus erythematosus (SLE).University Hospital.81 patients with SLE (1999 American College of Rheumatology criteria; 72 (89%) women and nine (11%) men, mean age 42.9 (SD 16.1) years), who regularly attended a specialist SLE clinic were examined. The control group comprised 280 patients attending a general practitioner (193 (69%) women and 87 (31%) men, mean age 44.7 (SD 11.2) years). Joint laxity was measured according to the criteria of Beighton et al (total score 4 or more). A regression analysis was performed.Thirty nine (48%) patients with SLE and 42 (15%) of the control group were hypermobile. A logistic regression model was developed. The odds ratio of the association between laxity and SLE after adjustment for age and sex was 2.31 in the group younger than 49 years, and 17.99 in the group aged 49 years or older. Neither the clinical and analytical profile nor the use of corticosteroids was related to joint laxity.Patients with SLE showed more hypermobility than controls. Hypermobility was more profound in older patients with SLE (> or =49 years). Joint laxity was not associated with any clinical or analytical pattern. Treatment with corticosteroids was not related to joint laxity.
Duodenal Ulcer Among Northwest Coastal Indian Women
Authors: JAMES H. SHORE, DENNIS L. STONE
Journal: American Journal of Psychiatry (1973)

Indian women from a Northwest coastal tribe were noted to have a high prevalence rate of duodenal ulcer, about four times greater than that for non-Indian women and above the rate of occurrence in Southwestern Indians. The authors analyze this high rate in light of the cultural heritage and current acculturation stresses, discussing the historical role of Northwest Indian women in a matrilineal culture and pressures on the Indian woman who lives in a minority-group/poverty-level community.
Glucose Fluctuations and Oxidative Stress
Authors: Kevin B. Moore
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Analysis of the Expression of Toll-like Receptors 2 and 4 in Keratinocytes of Patients with Extensive Dermatophytosis due Trichophyton rubrum
Authors: P.R. Criado, C.B. Oliveira, C. Vasconcellos, N.Y.S. Valente, M.N. Sotto, F. Guedes Luiz, W. Belda Junior
Journal: Journal of Allergy and Clinical Immunology (2012)
Ethical Principles for Everyone
Authors: Joseph J. Mazza
Journal: Annals of Internal Medicine (2001)

Letters19 June 2001Ethical Principles for EveryoneJoseph J. Mazza, MDJoseph J. Mazza, MDMarshfield Clinic; Marshfield, WI 54449-5777 (Mazza)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-134-12-200106190-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with interest Dr. Davidoff's lucid editorial on ethical principles for everyone in health care (1). The unfortunate reality of all of this, and a major impediment to implementing ethical principles and providing appropriate, basic health care for everyone, is the fact that we are a financially driven society avidly attached to and dependent on the global proliferation of the “world market.” Our priorities, decisions, and future are determined by the powerfully integrated network of big business and finance. In the wake of all this is the continuing deterioration of our environment and public health, also ...Reference1. Davidoff F. Changing the subject: ethical principles for everyone in health care [Editorial]. Ann Intern Med. 2000;133:386-9. [PMID: 0010979885] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Marshfield Clinic; Marshfield, WI 54449-5777 (Mazza) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoChanging the Subject: Ethical Principles for Everyone in Health Care Frank Davidoff Ethical Principles for Everyone Alan R. Nelson Ethical Principles for Everyone Frédéric Pochard , Marc Grassin , and Elie Azoulay Ethical Principles for Everyone Nelson G. Goodman Ethical Principles for Everyone Frank Davidoff Metrics 19 June 2001Volume 134, Issue 12Page: 1151KeywordsForecastingHealth careHealth economicsPrevention, policy, and public health ePublished: 19 June 2001 Issue Published: 19 June 2001 Copyright & PermissionsCopyright © 2001 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Cancer occurrence in a cohort of patients treated with cimetidine.
Authors: H Moller, K Lindvig, R Klefter, J Mosbech, O Moller Jensen
Journal: Gut (1989)

The possible carcinogenic effects of antisecretory agents used in the treatment of gastric and duodenal ulcer were investigated in a population based cohort study of 16,739 patients who were prescribed the H2-antagonist cimetidine between 1977 and 1981. An excess risk for gastric cancer was observed, with a relative risk of about 10 in the first year after beginning use of the drug, which decreased thereafter. A similar pattern was seen for cancers of the colon, pancreas and gall bladder, and for non-Hodgkin's lymphoma. These increased risks probably represent cases in which a malignancy was misdiagnosed as a gastric ulcer. The excess risk for gastric cancer was unaffected by the method of diagnosis, the risk in those who had undergone an endoscopy being similar to those who had been diagnosed by an x-ray examination. A relative risk of 1.5-2.0 was observed for cancer of the respiratory organs, with no effect of latency, indicating that there are common risk factors for peptic ulcer and for lung cancer. Although the observed increases in cancer risk in persons receiving cimetidine is probably caused by factors other than a carcinogenic action of the drug itself, this possibility cannot be ruled out because of the short period of follow up.
Glasgow Women Medical Students: Some Facts and Figures
Authors: M. C. Timbury, G. C. Timbury
Journal: BMJ (1971)

A questionaire was sent to 343 women medical undergraduates at the University of Glasgow, and 317 replied. Of the respondents, 36% had a member of their family in medicine and 15% had either one or both parents a doctor: 45% had a working mother. Half of all the students had doubts about medicine as a career, and the proportion of these rose with seniority. Doubts were mainly due to the length of the medical course but the girls also recognized the difficulty of combining a medical career with family life. There was a significant correlation between having doubts about a medical career and having a mother who worked.Half the girls said they would prefer to work in hospital after qualification-the favourite specialties being paediatrics and obstetrics; only a quarter said they would like to do general practice. The need for careers advice which links actual career openings and the wish of most women to combine medical work with marriage and child-rearing is emphasized. The majority of the students saw a doctor's primary role as the giving of advice and reassurance.
A phase I study of pentosan polysulfate sodium in patients with advanced malignancies
Authors: R.M. Lush, W.D. Figg, J.M. Pluda, R. Bitton, D. Headlee, D. Kohler, E. Reed, O. Sartor, M.R. Cooper
Journal: Annals of Oncology (1996)

Pentosan polysulfate (xylanopolyhydrogensulfate) is a semi-synthetic sulfated heparinoid polysaccharide which has been used as an anticoagulant for nearly thirty years in Europe. It antagonizes the binding of bFGF to cell surface receptors and has thus been evaluated for antitumor activity in several animal models and human tumor cell lines. In two angiogenic models pentosan has been shown to inhibit bFGF stimulation of angiogenesis. Previous clinical studies have determined the coagulation effects of pentosan to be the dose-limiting toxicity.We conducted a phase I study designed to define the duration-limiting toxicity associated with progressive prolongation of a continuous intravenous infusion (three, five, and eight weeks). This study was not designed to escalate the dose of pentosan beyond that required to maintain the activated partial thromboplastin time (aPTT) between 1.8 and 2.2 times the baseline value.Thirteen patients with advanced stage metastatic cancer were enrolled (median age 50 years, range 34 to 61 years). Four patients were treated in cohort #1 (three weeks of infusional therapy), five patients were treated in cohort #2 (five weeks of therapy), and four patients in cohort #3 (eight weeks of therapy). All patients experienced a progressive prolongation of their aPTT and PT. Furthermore, all patients experienced at least grade I thrombocytopenia. Other complications were, in general, mild. One patient developed grade III liver abnormalities while receiving the eight-week infusion and another patient developed grade IV thrombocytopenia while receiving the same regimen. One patient with colon cancer had stable disease for 24 weeks, while the remaining 12 patients had no objective evidence of response.Pentosan was well tolerated when doses were adjusted for aPTT prolongations and a five-week cycle appeared to be the maximum tolerated duration of infusion (initially 4 mg/kg/day). One patient had stable disease, but there was no objective tumor response noted in the remaining 12 patients.
Ethnic Medicine in the Southwest
Authors: Marjorie C. Meehan
Journal: JAMA (1978)

Physicians trained in scientific medicine often are unaware of the beliefs about health and illness held by members of various ethnic groups. This book may help to provide a remedy. In it, four anthropologists study the medical beliefs and practices of four ethnic communities in Arizona. In a small black neighborhood, Loudell Snow found that the residents made little distinction between different diseases, lumping them all together as "the misery." They believed that some sicknesses were due to natural causes—exposure to the elements, overeating, or overwork. Others might represent punishment for sin; still others were brought about by witchcraft. The inhabitants placed great emphasis on the condition of the blood, worrying about "high blood," "low blood," and impurities that might be avoided by frequent use of laxatives. Home remedies, especially herbs, were used extensively; faith healing was popular, but regular physicians might be consulted to get medicine. In a Mexican-American
Ultraviolet Radiation and Pterygium
Authors: Hugh R. Taylor
Journal: JAMA (1982)

<h3>To the Editor.—</h3> Joseph F. Novak, MD, has concluded that work-related ultraviolet radiation exposure is unlikely to be a direct cause of recurrent pterygium in a welder (1981;246:1019). His observation that pterygia do not occur more frequently in welders than in other groups is compatible with the findings of Emmett et al.<sup>1</sup>Those authors found no increase in the prevalence of pterygium in welders who had worked for at least ten years, compared with either other workers incidentally exposed to welding or a control group that had never worked near welders. Welders are normally shielded from radiation, although concern has been expressed about the adequacy of this protection, and recently, alternative types of shields have been suggested.<sup>2</sup> However, Dr Novak's statement that "Ultraviolet radiation has not been reported as a cause or inciting factor for pterygium" requires correction. It is more than 15 years since Cameron<sup>1</sup>pointed out
C1Q synthesis by tissue mononuclear phagocytes from normal and from damaged rat liver: Up-regulation by dexamethasone, down-regulation by interferon gamma, and lipopolysaccharide
Authors: T Armbrust
Journal: Hepatology (1997)

The subcomponent of complement C1, C1q, mediates complement activation via the classical pathway, and therefore may play an important role in the inflammatory processes in which complement activation is involved. The aim of our study was to investigate C1q synthesis by macrophages of normal and of acutely damaged livers. The localization of C1q in liver tissue was studied by immunohistochemistry. Rat liver tissue macrophages were isolated from normal as well as from acutely damaged (carbon tetrachloride model) liver, and were separated into small, monocyte-like phagocytes and large, mature tissue macrophages, as revealed by immunocytochemistry. C1q gene expression was studied by endogeneous labeling of newly synthesized proteins, immunoprecipitation, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), and by reverse-transcription polymerase chain reaction (RT-PCR) of C1qB messenger RNA (mRNA). Semiquantitative analysis was performed by Northern blotting of total RNA and hybridization with the radioactively labeled RT-PCR product. C1 esterase inhibitor synthesis was studied in parallel. For comparison, C1q and C1-inhibitor synthesis were also investigated in blood monocytes and peritoneal macrophages. C1q was weakly detectable in sinusoidal cells of the normal liver. C1qB mRNA, as well as constitutive synthesis and secretion of C1q, was clearly detected in freshly isolated and cultured Kupffer cells from normal rat liver. In comparison, newly recruited "inflammatory" macrophages from damaged rat liver synthesized considerably lower amounts of the protein, similar to what was found in the monocyte-like macrophages of normal liver and in peritoneal macrophages. Monocyte C1qB mRNA was not detected even by RT-PCR, and remained undetectable during the time in culture. Similar behavior was observed for C1-inhibitor synthesis. Treatment of the cultures with interferon gamma (IFN-gamma) or lipopolysaccharide (LPS) strongly decreased, whereas treatment with dexamethasone strongly increased C1q gene expression in the macrophage populations, and induced C1qB mRNA in cultured monocytes, as revealed by RT-PCR. Kupffer cells of normal liver may produce considerable amounts of C1q, whereas the inflammatory macrophages of the acutely damaged liver may not be so important for the synthesis of C1q.
Licensing of International Medical Graduates
Authors: Jonas Singer
Journal: JAMA (1992)

<h3>To the Editor.</h3> —The otherwise informative article on licensure of international medical graduates (IMGs) concluded that conversation with US medical graduates regarding licensing boards "might lead IMGs to believe that they are not treated much differently after all."<sup>1</sup>However, the article misses the main point of contention. The licensing boards have introduced protectionist policies using the excuse of necessity for protecting the public from suboptimally trained IMGs. The discrimination is extended not only to those who are truly suboptimally trained but also to those who have better training than the average US medical graduate. For instance, board-certified ophthalmologists from Great Britain or South Africa had, by the time of their board-equivalent examinations, undergone more rigorous (and longer) training than their US counterparts. Regardless whether one considers the respective ophthalmology residencies equivalent, in no way can any licensing board justify the discrimination that follows the arrival of such an ophthalmologist in
Criteria for Surgery-Reply
Authors: Robert V. Elliott
Journal: JAMA (1981)

<h3>In Reply.—</h3> There is a general misconception that the PSRO is a faceless, unilateral entity that does "things" such as "criteria selection." In fact, criteria are selected by groups of physicians with expertise in their respective areas. In the study described in our article, a subcommittee of the Colorado Health Care Standards Committee established the criteria. This committee is composed of representatives appointed by their state-wide specialty societies. In the case of obstetrics and gynecology, the gynecologist on the committee was the appointed representative of the Colorado Obstetrics-Gynecology Society. The criteria described are part of a structure that precludes their application by "bureaucrats." The criteria were used as guidelines by nurse reviewers to screen out cases for physician peer review. Physicians whose cases fell outside the indications were not "castigated." Every case that fell outside of the indications was reviewed by a peer physician. The attending physician was contacted only
The Effects of Vitamin D Supplementation on Exercise Capacity and Echocardiographic Parameters in Patients with Systolic Heart Failure
Authors: Hakan Muhammed Taş, Ziya Simsek, Zakir Lazoglu, Murat Akbas, Adem Gungor, Ednan Bayram, Habip Bilen
Journal: Journal of the American College of Cardiology (2013)
Treatment of Carcinoma of Rectum by Radium*
Authors: T. E. JONES
Journal: Annals of Internal Medicine (1927)

Article1 July 1927Treatment of Carcinoma of Rectum by Radium(Presentation of Case)T. E. JONES, M.D.T. E. JONES, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-1-1-13 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhile we feel at the present time that whenever possible the best treatment for cancer of the rectum is some type of radical operation, there remain two classes of patients to whom we must offer some alternative treatment: first, those who are in an inoperable condition; and second, those who refuse the radical operation. There are a considerable number in the latter class who must command our attention, for if we do not offer another therapeutic measure they will immediately become the prey of quacks. We have therefore resorted to the use of radium in the treatment of these two... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Cleveland Clinic Cleveland, Ohio*Clinical Discussion given before the American College of Physicians at the Cleveland Clinic, February 22-25, 1927. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByRadiation therapy of cancer of the colon and rectumThe present status of radiation therapy in carcinoma of the anus, rectum and sigmoid colon 1 July 1927Volume 1, Issue 1Page: 13-16KeywordsCancer treatmentRectal cancerRectum Issue Published: 1 July 1927 PDF DownloadLoading ...
Morbidity or Mortality Outcomes Associated With Prophylactic Salpingo-oophorectomy
Authors: Dennis McCunniff
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal