tbuckley/cabot-search huggingface dataset:
Abstract 3999: Baseline Proton Pump Inhibitor Use is Associated with Increased Cardiovascular Events With and Without the Use of Clopidogrel in the CREDO Trial
Authors: Steven P Dunn, Tracy E Macaulay, Danielle M Brennan, Charles L Campbell, Richard J Charnigo, Susan S Smyth, Peter B Berger, Steven R Steinhubl, Eric J Topol
Journal: Circulation (2008)

Ex vivo data suggest that a pharmacokinetic interaction may exist between proton pump inhibitors (PPIs) and clopidogrel, decreasing the antiplatelet effect of the latter. We assessed that baseline PPI use would increase the 28-day and 1-year composite endpoints in patients undergoing, or at high likelihood of undergoing, PCI randomized to a loading dose and 1-year clopidogrel versus just 4 weeks of clopidogrel, in addition to daily aspirin, in the CREDO trial. Twenty-eight day (Death/MI/UTVR) and 1-year (Death/MI/Stroke) primary endpoints were analyzed based on PPI use at study entry. For each primary endpoint, Cox proportional hazard or logistic regression models were fit to identify the risk of PPI use in the patients receiving clopidogrel, placebo, and in the overall population. Clopidogrel reduced adverse events at 1-year to an approximately similar degree whether or not patients were on a PPI (Table 1 ). PPI use also increased the incidence of the 28-day endpoint in patients receiving clopidogrel or placebo, although this did not achieve significance (Table 1 ). Additionally, PPI use was independently associated with the 28 day (HR 1.6, 95% CI 1.08 –2.5, p=0.022) and 1 year (HR 1.5, 95% CI 1.1–2.1, p=0.012) endpoints in the overall trial population. Baseline PPI was associated with an increase in cardiovascular events at 1-year in both patients receiving clopidogrel and the overall trial population. However, clopidogrel reduced adverse events at one year to an approximately similar degree whether or not patients were on a PPI. Table 1
Warfarin-associated intracranial hemorrhage during anticoagulation therapy
Authors: So-My Koo, Yang-Ki Kim, Soo-taek Uh, Ki-Up Kim
Journal: European Respiratory Journal (2014)

The incidence of venous thromboembolism including pulmonary embolism and deep vein thrombosis is increasing in Korea. As the use of vitamin K antagonists is increased, the risk of anticoagulant-related intracranial hemorrhage(ICH) is emphasized. Anticoagulant-related ICH in patients with anticoagulation therapy is approximately 0.2% per year occurred. There is no study about anticoagulant-related ICH in Korea. We retrospectively reviewed the records of ICH patients at Soonchunhyang University Hospital, Seoul, Korea, from 1 January 2004 to 31 December 2012. We divided into two groups depending on whether the administration of warfarin. The primary outcome was 30-day mortality. Secondary outcomes were the ways for reversal of hemorrhage and overall outcomes. ICH hopitalizations were in 3,232 patients. Except exclusion criteria (n=721), among total 2,511 patients, the warfarin-associated ICH occurred in 50 patients(2.0%). The 30-day mortality in warfarin-associated ICH patients was 40% compared with 13% in non-warfarin-associated ICH patients. The ways for reversal of hemorrhage were vitamin K(53% vs 8.3%,p
Abstract 15293: Does Early Treatment with Oral Beta-blockers Reduce In-hospital Mortality in Patients with Acute Myocardial Infarction Undergoing Primary Angioplasty?
Authors: Toshikazu Jinnai, Hiroki Sakamoto, Takafumi Yamane, Masahiro Suzuki, Teruo Shiraki, Shinichi Minagoe, Hideo Kusuoka, Hiroyuki Yokoyama
Journal: Circulation (2010)
ECTOPIC PREGNANCY MASQUERADING AS AN ACUTE HEMOLYTIC CRISIS
Authors: B Z PAULSHOCK
Journal: Annals of Internal Medicine (1956)

Case Reports1 February 1956ECTOPIC PREGNANCY MASQUERADING AS AN ACUTE HEMOLYTIC CRISISBERNADINE Z. PAULSHOCK, M.D.BERNADINE Z. PAULSHOCK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-2-410 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt is almost a medical truism that ruptured ectopic pregnancies are clinically capricious, and therefore this diagnosis must always be kept in mind in the evaluation of abdominal symptoms in any female of childbearing age.1, 2The knowledge that acute hemolytic crises may clinically resemble surgical abdominal emergencies of various types has been repeatedly emphasized in the past several decades.3, 4, 5, 6No previous case report has been found of a patient with tubal rupture who was initially thought to be suffering an acute hemolytic crisis. For this reason a case is presented whose clinical picture seemed entirely consistent...Bibliography1. Campbell RM: The diagnosis and management of ectopic pregnancy, Am. J. Obst. and Gynec. 63: 54, 1952. CrossrefMedlineGoogle Scholar2. CarabbaSilberblatt RWB: Diagnostic variants in the syndrome of ectopic pregnancy, Am. J. Obst. and Gynec. 64: 1154, 1952. CrossrefMedlineGoogle Scholar3. Campbell EH: Acute abdominal pain in sickle cell anemia, Arch. Surg. 31: 607, 1935. CrossrefGoogle Scholar4. Bauer J: Sickle cell disease, Arch. Surg. 41: 1344, 1940. CrossrefGoogle Scholar5. WilsonPattersonDiggs HRHLW: Sickle cell anemia: a surgical problem, Ann. Surg. 131: 641, 1950. CrossrefMedlineGoogle Scholar6. Tomlinson WJ: Abdominal crises in uncomplicated sickle cell anemia, Am. J. M. Sc. 209: 722, 1945. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Wilmington, Delaware*Received for publication December 7, 1954.From the Department of Medicine, The Delaware Hospital, Inc., Wilmington, Delaware. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1956Volume 44, Issue 2Page: 410-412KeywordsAnemiaHemoglobinHospital medicinePregnancy ePublished: 1 December 2008 Issue Published: 1 February 1956 PDF downloadLoading ...
Abstract 6022: The Effect of Pre-Hospital Tirofiban on Early Stent Thrombosis in STEMI Patients Undergoing Primary PCI
Authors: Ton Heestermans, Isala Klinieken, Wouter van Werkum, Jurrien ten Berg, Evangelos Giannitsis, Thorsten Dill, Jan-Henk Dambrink, Isala Klinieken, Christian Hamm, Arnoud W van ’t Hof
Journal: Circulation (2008)

Objective The aim of this analysis was to assess the effect of pre-hospital initiation of high-dose (HD) tirofiban on the incidence of early stent thrombosis (ST) in patients undergoing primary PCI for acute myocardial infarction. Methods Patients were randomized to HD tirofiban or no tirofiban in the ambulance on top of 600 mg clopidogrel, 500 mg aspirin and 5000 IU unfractionated heparin. ST was defined according to the Academic Research Consortium definitions of “definite” and “probable” stent thrombosis. Results A total of 1073 out of 1398 patients (76.8%) underwent primary PCI with stent implantation. Overall, “definite” or “probable” ST occurred in 39 patients (3.6%) at 30 days. The incidence in the no tirofiban or placebo group was 5.2% (28/537; 27 definite and 1 probable) versus 2.1% (11/536; 10 definite and 1 probable) in the HD tirofiban group (p=0.006). In univariate analysis, predictors of ST were no pre-hospital initiation of HD tirofiban (p=0.006), previous myocardial infarction (p=0.016), TIMI risk score &gt;3 (p=0.027) and TIMI major bleeding (p=0.002). By multivariate analysis, no pre-hospital initiation of HD tirofiban (Odds ratio [OR] 2.54, 95% confidence interval [CI] 1.21–5.32; p=0.013), previous myocardial infarction (OR 3.32, 95%-CI 1.35– 8.18; p&lt;0.01), and TIMI major bleeding (OR 8.40, 95%-CI 2.24 –31.46; p=0.002) were independent predictors of early ST. Thirty day mortality was significantly higher in those with ST (10.3% versus 1.7%, p&lt;0.001). Conclusion Pre-hospital initiation of high dose tirofiban reduces the 30-day incidence of stent thrombosis in STEMI patients treated with primary PCI. Early stent thrombosis was associated with poor outcome.
Readability of Notice of Privacy Forms Used by Major Health Care Institutions
Authors: Peter Breese, William Burman
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Role of the Radial Margin
Authors: Jonathan Efron
Journal: JAMA Surgery (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Current Therapy in Hematology/Oncology.
Authors: Michael C. Brain, Paul P. Carbone
Journal: Annals of Internal Medicine (1991)

Haematology : Aplastic anaemia and allied disorders Megaloblastic anaemia Autoimmune haemolytic anaemia Cold haemaglutinin disease Polycythaemia vera Hairy-cell leukaemia Bone marrow transplantation Haemophilia Von Willebrand's disease Viral infections in the compromised host. Oncology : Principles of cancer Primary management of breast cancer Carcinoma of the oesophagus Gastric cancer Pancreatic cancer Carcinoma of the uterine cervix and endometrium Chemotherapy for osteogenic sarcoma Paediatric solid tumour Carcinoma of the adrenal cortex Hodgkin's disease Malignant mesothelioma Malignant melanoma.
A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy
Authors: Edwin M. Stone, Andrew J. Lotery, Francis L. Munier, Elise Héon, Bertrand Piguet, Robyn H. Guymer, Kimberlie Vandenburgh, Pascal Cousin, Darryl Nishimura, Ruth E. Swiderski, Giuliana Silvestri, David A. Mackey, Gregory S. Hageman, Alan C. Bird, Val C. Sheffield, Daniel F. Schorderet
Journal: Nature Genetics (1999)
Systems for emergency care
Authors: J. Nicholl
Journal: BMJ (2000)

The British government's announcement of the first 36 new NHS “walk in centres” is the latest in a series of important changes in the provision of immediate access services over the past 20 years.1 A study of first contact out of hours care in England 16 years ago recorded only attendances at accident and emergency departments, general practitioners' home visits and telephone advice, and visits by deputising services.2 Contacts with regional trauma centres, minor injury units, general practitioners' out of hours cooperative treatment centres, community pharmacies, and community mental health teams, for example, were either negligible or non-existent.

The recent development of triage and advice telephone services, such as NHS Direct,3 has further complicated the picture, and now the government proposes 36 walk in centres (with more under consideration) to “offer a service to the public, when the public need it and where the public need it.”1 These services, based in shops, health centres, and hospitals will be nurse led, with access to general practitioners in some cases, and will offer extended opening hours, including evenings and weekends—but how do they fit into the changing …
Activation of non neuronal cholinergic system induces proliferation and angiogenesis in MCF-7 human mammary adenocarcinoma cells
Authors: Gabriel Fiszman, Maria Middonno, Eulalia de la Torre, Mariana Farina, Alejandro Espanol, Maria Sales
Journal: Cancer Research (2007)

4380   Muscarinic acetylcholine receptors (mAChR) are members of the G-protein coupled receptor family. These membrane receptors play key physiological roles and changes in their expression and/or function can be involved in several diseases. We had previously demonstrated that mAChR expression is up-regulated in LM2, LM3 and LMM3 cells, three different cell lines derived from distinct murine mammary adenocarcinomas that spontaneously arose in BALB/c female mice, in comparison with normal murine mammary cells. Stimulation of mAChR with the synthetic muscarinic agonist carbachol (CARB) potentiated different steps of tumor progression. Less knowledge is available about the response of different mAChR subtypes to muscarinic agonists in human tumor mammary cells. Here we investigate the actions of CARB on human adenocarcinoma MCF-7 cells proliferation and in vivo neovascular response. We observe that CARB stimulates human breast tumor cells proliferation measured using the conversion of MTS tetrazolium salt to formazan. The maximal proliferation effect was observed with 10 -9  M CARB. This action was due to M 3  and M 1  receptors activation because 4-diphenylacetoxi-N-methylpiperidine (4-DAMP) or pirenzepine, respectively, reduced CARB action. We also demonstrated the participation of phospholipase C, protein kinase C and nitric oxide synthase (NOS) signaling pathway in CARB-induced MCF-7 cells proliferation. The agonist action was reverted by preincubating cells with the correspondent enzymatic inhibitors: 10 -6 M carboxyphenyl-N,N diphenylcarbamate, 10 -7 M H-7 or 10 -4 M N G monomethyl-L-arginine. Particularly we confirmed the expression of NOS1 and NOS3 isoforms by Western blot. Nitric oxide production derived from calcium dependent NOS was tested by measuring nitrite accumulation in culture supernatants by Griess reagent. In addition 10 -9 M CARB that was the most potent concentration to produce nitrite accumulation, stimulates blood vessels formation induced in vivo by tumor cells. This response was evaluated in oestrogenized nude mice inoculated intradermically in both flanks with breast tumor cells. We can conclude that non neuronal cholinergic system activation stimulates MCF-7 tumor cells growth and neovascular response promoting tumor progression
Serum levels of clozapine and norclozapine in patients treated with selective serotonin reuptake inhibitors
Authors: F Centorrino, R J Baldessarini, F R Frankenburg, J Kando, S A Volpicelli, J G Flood
Journal: American Journal of Psychiatry (1996)

The selective serotonin reuptake inhibitor (SSRI) fluoxetine can increase serum levels of clozapine and norclozapine, but effects of other SSRIs are unknown. Thus, the authors evaluated interactions of clozapine with fluoxetine, paroxetine, and sertraline.Serum clozapine and norclozapine concentrations were assayed in 80 psychiatric patients, matched for age and clozapine dose, given clozapine (mean dose = 279 mg/day) alone or with fluoxetine (mean dose = 39.3 mg/day), paroxetine (mean = 31.2 mg/day), or sertraline (mean = 92.5 mg/ day). Each patient's dose of clozapine was stable for at least a month before serum sampling.Concentrations of clozapine plus norclozapine averaged 43% higher, and the risk of levels higher than 1000 ng/ml was 10-fold greater (25%), in the patients taking SSRIs, with minor differences between patients taking the individual SSRIs.SSRIs can increase circulating concentrations of clozapine and norclozapine, sometimes to potentially toxic levels.
How to Keep Our Liberty: A Program for Political Action
Authors: Raymond Moley
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A patient who changed my practice: "That's very nice, but will it get me pregnant?"
Authors: R. Varnam
Journal: BMJ (2001)

I have to confess, I didn't understand the question at the time. A year later, I am starting to. I was an eager new general practitioner and member of a research team investigating how the internet might influence patients' use of primary care, and we had just begun offering free internet access at our deprived inner city practice. I had filled the waiting room with posters advertising the service, and a member of staff was on hand to guide newcomers through the web. With our new PC and a cup of coffee, we would help …
Abstract 1546: The research of the mechanism of lung cancer carcinogenesis and the target gene of microRNA-20a in lung cancer small cells
Authors: Tan Xiaogang, Hu Mu, Zhi Xiuyi, Jin Shimeng
Journal: Cancer Research (2014)

Abstract Purpose: Recent studies have suggested that microRNA biomarkers could be useful for stratifying lung cancer subtypes, but microRNA signatures varied between different populations. Small cell lung cancer (SCLC) is the lowest differentiation degree and the highest malignant subtype of lung cancer that urgently needs biomarkers to aid patient management. Here, we undertook the first comprehensive investigation on microRNA in Chinese SCLC patients of limited stage. Experimental Design: MicroRNA expression was measured in cancerous and noncancerous tissue pairs strictly collected from Chinese SCLC patients of limited stage, who had not been treated with chemotherapy or radiotherapy prior to surgery. The molecular targets of proposed microRNA were further examined. Results: We identified that high expression of hsa-miR-20a was associated with poor survival in these 20 SCLC patients by Kaplan-Meier analysis (P=0.03), This association was independently validated in a separate cohort of 38 SCLC patients in Kaplan-Meier analysis(P=0.046). We then determined that the tumor suppressor PTEN is a target of hsa-miR-20a. Expression of hsa-miR-20a in a human lung cancer cell line repressed PTEN activity. Conclusions: Our results identified a new prognostic biomarker of SCLC, hsa-miR-20a. Note: This abstract was not presented at the meeting. Citation Format: Tan Xiaogang, Hu Mu, Zhi Xiuyi, Jin Shimeng. The research of the mechanism of lung cancer carcinogenesis and the target gene of microRNA-20a in lung cancer small cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1546. doi:10.1158/1538-7445.AM2014-1546
Abstract 13237: Impact of Pain and Heart Failure Symptom Severity on Physical Performance
Authors: Suzanne Wingate, Kushang V Patel, Jack Guralnik, Sarah Goodlin
Journal: Circulation (2014)

Introduction: The purpose was to determine whether pain and heart failure (HF) symptom severity are associated with physical performance in patients with advanced HF. Methods: Cross-sectional data were analyzed on 160 adults with advanced HF (dyspnea or fatigue at rest or with minimal exertion despite optimal medical therapy). Demographics, comorbidity (Charlson), pain (Brief Pain Inventory), HF symptom severity (Kansas City Cardiomyopathy Questionnaire), and depression (Patient Health Questionnaire-9) data were obtained. Physical function was assessed with the Short Physical Performance Battery (SPPB), a measure of lower extremity function (timed walking speed, standing balance, chair rises). Scores range 0-12 (higher scores=better). Multivariable linear regression assessed the associations of pain and HF symptom severity with SPPB scores. Results: Subjects had a mean (standard deviation [SD]) age of 67.0 (15.9) years, 43% were women, and 19.6% were non-white. The mean (SD) SPPB score was 6.4 (3.6), indicating limited mobility function. Subjects in the highest quartile of pain (severe), as compared to those in the lowest quartile, had clinically significant decreased SPPB scores (b coefficient = -2.1; p&lt;0.01), adjusting for demographics, comorbidity, and depression. However, this association was no longer significant when adjusting for HF symptom severity. For every SD increase in HF symptom severity, SPPB scores decreased 1.2 points (p&lt;0.01). The combined effect of pain and HF symptom severity on SPPB scores (Table) suggests that pain exacerbates the impact of HF symptom severity on physical performance. Conclusions: Among patients with advanced HF, symptom severity was strongly associated with decreased physical performance. Pain may exacerbate HF symptom severity and contribute to decline in mobility function.
Measles outbreak in Styria, Austria, March-May 2009
Authors: S Kasper, H Holzmann, S W Aberle, M Wassermann-Neuhold, H Gschiel, O Feenstra, F Allerberger, D Schmid
Journal: Eurosurveillance (2009)

In the last week of March 2009, five measles cases among students of an anthroposophic school were reported to the public health authorities in the Austrian province of Styria where only five cases had been reported in the whole of 2008. A descriptive epidemiological investigation of the measles outbreak was performed. Between 2 March and 10 May 2009, 37 cases of measles were identified in Styria: 33 confirmed outbreak cases and four probable outbreak cases. The measles outbreak spread from the general population (12 cases) to an anthroposophic community (25 cases). Cases outside of the anthroposophic community were mostly over 10 years of age (10/12). Thirty-five cases were unvaccinated, and two of the 37 had received one dose of measles, mumps, rubella vaccine. Following a measles outbreak in Salzburg in 2008 with 394 cases, this outbreak reemphasises the continued need for additional vaccination campaigns in population groups over the age of 10 years.
Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia
Authors: Antje Pittner, Marek Nalos, Pierre Asfar, Yan Yang, Can Ince, Michael Georgieff, Uwe Brückner, Peter Radermacher, Gebhard Fröba
Journal: Intensive Care Medicine (2003)