PENICILLIN IN THE TREATMENT OF EARLY SYPHILIS, 429 PATIENTS TREATED WITH 1,200,000 UNITS IN 90 HOURS
Authors: R M CRAIG, G X SCHWEMLEIN
Journal: Annals of Internal Medicine (1947)

Article1 August 1947PENICILLIN IN THE TREATMENT OF EARLY SYPHILIS, 429 PATIENTS TREATED WITH 1,200,000 UNITS IN 90 HOURSROBERT M. CRAIG, M.D., GEORGE X. SCHWEMLEIN, M.D., ROBERT L. BARTON, M.D., THEODORE J. BAUER, M.D., HERMAN N. BUNDESEN, M.D., F.A.C.P.ROBERT M. CRAIG, M.D.Search for more papers by this author, GEORGE X. SCHWEMLEIN, M.D.Search for more papers by this author, ROBERT L. BARTON, M.D.Search for more papers by this author, THEODORE J. BAUER, M.D.Search for more papers by this author, HERMAN N. BUNDESEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-2-225 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe problem of time-dose relationship in the treatment of early syphilis has been foremost in the investigation of this mode of therapy. It has been established that doses of less than 1.2 million units of penicillin were inadequate as measured by the relapse rate.1, 2The use of a total dose of 1.2 million units of penicillin administered over different time periods, and the combination of this amount with artificial fever therapy (hypertherm) was delegated to this Center by the National Research Council.The present report concerns only the group of patients treated by the following schedule: each patient received...Bibliography1. MOOREMAHONEYSCHWARTZSTERNBERGWOOD JEJFWTWB: Treatment of early syphilis with penicillin; preliminary report of 1,418 cases, Jr. Am. Med. Assoc., 1944, cxxvi, 67. CrossrefGoogle Scholar2. BAUERBUNDESENCRAIGSCHWEMLEINBARTON TJHNRMGXRL: The treatment of early syphilis with 600,000 units of penicillin in seven and one-half days, Am. Jr. Syph., Gonor. and Ven. Dis., 1947, xxxi, 45. Google Scholar3. MAHONEYARNOLDHARRIS JFRCA: Penicillin treatment of early syphilis, Ven. Dis. Inform., 1943, xxiv, 355. Google Scholar4. BINKLEYKILE GWRL: Rapid treatment of early syphilis with small doses of penicillin; observations in 159 cases, Arch. Derm. and Syph., 1945, li, 200. CrossrefGoogle Scholar5. BUNDESENCRAIGSCHWEMLEINBARTONBAUER HNRMGXRLTJ: The rapid treatment of early syphilis with the combined use of penicillin and mapharsen, Am. Jr. Syph., Gonor. and Ven. Dis., 1946, xxx, 475. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication October 15, 1946.From the Chicago Intensive Treatment Center, Venereal Disease Control Program, Chicago Board of Health in coöperation with the United States Public Health Service.The work described in this paper was done under a contract, recommended by the Committee on Medical Research, between the office of Scientific Research and Development and the Chicago Intensive Treatment Center.†Senior Assistant Surgeon, (R) U.S.P.H.S.‡Senior Surgeon, U.S.P.H.S.; Venereal Disease Control Officer, Chicago.**Senior Surgeon, (R) U.S.P.H.S. (Inactive); President Chicago Board of Health. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySyphilis 1 August 1947Volume 27, Issue 2Page: 225-230KeywordsHyperthermiaMedical servicesPenicillinSexually transmitted diseasesSurgeonsSyphilis Issue Published: 1 August 1947 PDF downloadLoading ...