tbuckley/cabot-search huggingface dataset:
Receptor-type protein tyrosine phosphatase gamma (PTPγ), a new identifier for myeloid dendritic cells and specialized macrophages
Authors: Daniele Lissandrini, William Vermi, Marzia Vezzalini, Silvano Sozzani, Fabio Facchetti, Graziella Bellone, Andrea Mafficini, Francesca Gentili, Maria Grazia Ennas, Cristina Tecchio, Claudio Sorio
Journal: Blood (2006)
Case 50-1970
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, William C. Moloney, Max Goodman, Kurt J. Bloch
Journal: New England Journal of Medicine (1970)

Presentation of CaseA 62-year-old woman entered the hospital because of lymphadenopathy.Thirty-four months earlier she was admitted to another hospital because of decreased hearing and nasal congestion. Hypertrophied adenoidal tissue was found, and an adenoidectomy was performed, with a pathological diagnosis of chronic inflammation. She returned four months later with similar complaints, and a biopsy of a polypoid nasopharyngeal mass was interpreted as showing lymphoid hyperplasia. One month thereafter shotty supraclavicular lymphadenopathy was found; a biopsy was again interpreted as showing chronic inflammation. Over the ensuing eight months there were recurrent episodes of serous otitis media. A stapes-mobilization procedure . . .
Abstract 1110: Differential expression of cholecystokinin receptors and their ligands in normal and neoplastic pancreas
Authors: Emily Ortega, Jill P. Smith
Journal: Cancer Research (2011)

Abstract Background: The gastrointestinal peptide gastrin has been identified in fetal pancreas up until week 14 where it is thought to play a role in growth and differentiation. Gastrin has also been identified as an important growth factor that stimulates pancreatic cancer through the CCK-B and CCK-C receptors by an autocrine mechanism. Hypothesis: It is hypothesized that gastrin re-expression is important to pancreatic carcinogenesis. Methods: The mRNA from normal human pancreas tissue was isolated and endpoint RT-PCR was performed to detect RNA levels of gastrin and CCK peptide, using gastrin specific and CCK peptide specific primers, respectively. PCR products were visualized on an ethidium bromide stained gel after electrophoresis. Normal human pancreatic tissue samples were evaluated for gastrin and CCK by immunohistochemistry. Tissues were flash frozen and sectioned at a thickness of 8-10uM. Non-specific sites were blocked, followed by exposure to either gastrin or CCK antisera. Peptide presence was assessed using AF568 (Alexa Fluor) goat anti-rabbit secondary antibody. Results: The end-point RT-PCR showed significant levels of CCK-B receptor and CCK peptide in normal pancreas samples. The gastrin end-point RT-PCR showed extremely low levels in all of the normal pancreas samples. Gastrin immunoreactivity was not detected in normal pancreas, however, staining of the positive control, an islet cell tumor, was reactive. The negative control, a GIST tumor, showed no staining as well. Conclusions: Normal pancreas possesses the receptor CCK-B and the peptide CCK. Gastrin is not present in normal pancreatic tissues, but is detected in neoplastic pancreatic samples. Therefore, the re-expression of gastrin plays a pivotal role in the development of pancreatic cancer and could be a potential trigger to pancreatic carcinogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1110. doi:10.1158/1538-7445.AM2011-1110
Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients
Authors: Y. Chao, T. Young, H. Tang, C. Hsu
Journal: Hepatology (1997)

It is still not clear why some alcoholic patients acquire certain organ–specific complications of alcoholism whereas other alcoholic patients acquire different ones. As we know the liver alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and cytochrome P4502E1 (P4502E1) are polymorphic at the ADH2, ADH3, and ALDH2 loci and the 5′–flanking region of the P4502E1. The aim of this study was to investigate the differences between Chinese alcoholic patients with cirrhosis and acute pancreatitis by studying the genetic polymorphisms of ADH2, ADH3, ALDH2, and P4502E1. Genotyping of ADH2, ADH3, ALDH2, and P4502E1 was performed using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) methods on peripheral white blood cell DNA from 75 alcoholic cirrhotic patients, 48 acute alcoholic pancreatitis patients, 19 heavy drinkers without liver disease or pancreatitis, and 235 controls. The results showed that the frequencies of the alleles ADH2*1 and ALDH2*1 in the alcoholic cirrhotic patients were significantly higher than those in the nonalcoholic controls. In acute alcoholic pancreatitis patients, only the frequency of allele ALDH2*1, not ADH2*1 was significantly higher than in the nonalcoholic controls. The allele frequency of ADH2*1 in acute pancreatitis patients was significantly lower ( P &lt; .01) than in alcoholic cirrhotic patients. The daily amount of alcohol consumption was significantly lower in patients with acute pancreatitis than in patients with cirrhosis ( P &lt; .0005). The genotype distributions of P4502E1, detected by RsaI and PstI , were not different among alcoholic cirrhotic patients, alcoholic pancreatitis patients, heavy drinker, and nonalcoholic controls. In conclusion, ALDH2*1 is the most important alcohol metabolizing gene affecting predisposition to alcoholism whereas the ADH2*2 gene may influence susceptibility to acute alcoholic pancreatitis. The patients with alcohol–induced cirrhosis and with alcohol–induced acute pancreatitis are of two different subpopulations.
TRENDS IN DOOR-TO-BALLOON TIME AND OUTCOMES FOLLOWING PRIMARY PCI FOR STEMI
Authors: Angela L. Brennan, Nick Andrianopoulos, Stephen Duffy, Andrew E. Ajani, David Clark, Jeffrey Lefkovits, Alexander Black, Matthew Brooks, Bryan Yan, Gishel New, Philippa Loane, Louise Roberts, Christopher Reid
Journal: Journal of the American College of Cardiology (2013)
Acquired Bilateral Telangiectatic Macules
Authors: Ji-Hye Park, Dong Jun Lee, Yoo-Jung Lee, Yong Hyun Jang, Hee Young Kang, You Chan Kim
Journal: JAMA Dermatology (2014)

We evaluated 13 distinct patients with multiple telangiectatic pigmented macules confined mostly to the upper arms to determine if the clinical and histopathological features of these cases might represent a specific clinical entity.We retrospectively investigated the clinical, histopathologic, and immunohistochemical features of 13 patients with multiple telangiectatic pigmented macules on the upper arms who presented between January 2003 and December 2012. Epidermal pigmentation, melanogenic activity, melanocyte number, vascularity, epidermal thickness, and perivascular mast cell number of the specimens were evaluated. Clinically, the condition favored middle-aged men. On histopathologic examination, the lesional skin showed capillary proliferation and telangiectasia in the upper dermis. Histochemical and immunohistochemical analysis revealed basal hyperpigmentation and increased melanogenic activity in the lesional skin (P < .05). No significant difference in epidermal thickness or mast cell number was observed between the normal perilesional skin and the lesional skin.The clinical and histopathologic features of these lesions were relatively consistent in all patients. In addition, the features are quite distinct from other diseases. Based on clinical and histologic features, we suggest the name acquired bilateral telangiectatic macules for this new entity.
Using Serum Creatinine To Estimate Glomerular Filtration Rate: Accuracy in Good Health and in Chronic Kidney Disease
Authors: Andrew D. Rule, Timothy S. Larson, Erik J. Bergstralh, Jeff M. Slezak, Steven J. Jacobsen, Fernando G. Cosio
Journal: Annals of Internal Medicine (2004)

Background: The National Kidney Foundation has advocated the use of the abbreviated Modification of Diet in Renal Disease (MDRD) equation to estimate glomerular filtration rate (GFR) from serum creatinine measurements in clinical laboratories. However, healthy persons were not included in the development of the MDRD equation. Objectives: To assess the accuracy of the MDRD equation in patients with chronic kidney disease compared with healthy persons and to develop a new equation that uses both patients with chronic kidney disease and healthy persons. Design: Cross-sectional study. Setting: The Mayo Clinic, a tertiary-care medical center. Participants: Consecutive patients (n = 320) who had an iothalamate clearance test specifically for chronic kidney disease evaluation and consecutive healthy persons (n = 580) who had an iothalamate clearance test specifically for kidney donor evaluation. Measurements: Serum creatinine levels, GFR, demographic characteristics, and clinical characteristics were abstracted from the medical record. Results: The MDRD equation underestimated GFR by 6.2% in patients with chronic kidney disease and by 29% in healthy persons. Re-estimated coefficients for serum creatinine and sex were similar to the original MDRD equation in the chronic kidney disease series but not in the healthy series. At the same serum creatinine level, age, and sex, GFR was on average 26% higher in healthy persons than in patients with chronic kidney disease (P < 0.001). A quadratic GFR equation was developed to estimate logarithmic GFR from the following covariates: 1/SCr, 1/SCr2, age, and sex (where SCr = serum creatinine). Limitations: The new equation was not developed in a general population sample. Elderly and African-American persons were underrepresented. Conclusion: The MDRD equation systematically underestimates GFR in healthy persons. A new equation developed with patients who have chronic kidney disease and healthy persons may be a step toward accurately estimating GFR when the diagnosis of chronic kidney disease is unknown.
A population of c-Kitlow(CD45/TER119)– hepatic cell progenitors of 11-day postcoitus mouse embryo liver reconstitutes cell-depleted liver organoids
Authors: Susana Minguet, Isabel Cortegano, Pilar Gonzalo, José-Alberto Martínez-Marin, Belén de Andrés, Clara Salas, David Melero, Maria-Luisa Gaspar, Miguel A.R. Marcos
Journal: Journal of Clinical Investigation (2003)

Embryo liver morphogenesis takes place after gastrulation and starts with a ventral foregut evagination that reacts to factor signaling from both cardiac mesoderm and septum transversum mesenchyme. Current knowledge of the progenitor stem cell populations involved in this early embryo liver development is scarce. We describe here a population of 11-day postcoitus c-Kitlow(CD45/TER119)– liver progenitors that selectively expressed hepatospecific genes and proteins in vivo, was self-maintained in vitro by long-term proliferation, and simultaneously differentiated into functional hepatocytes and bile duct cells. Purified c-Kitlow(CD45/TER119)– liver cells cocultured with cell-depleted fetal liver fragments engrafted and repopulated the hepatic cell compartments of the latter organoids, suggesting that they may include the embryonic stem cells responsible for liver development.
Fine Specificity of T Cells Reactive to Human PDC-E2 163-176 Peptide, the Immunodominant Autoantigen in Primary Biliary Cirrhosis: Implications for Molecular Mimicry and Cross-Recognition Among Mitochondrial Autoantigens
Authors: Hirohisa Shigematsu, Shinji Shimoda, Minoru Nakamura, Sho Matsushita, Yasuharu Nishimura, Norihiro Sakamoto, Yasunori Ichiki, Yoshiyuki Niho, Eric M. Gershwin, Hiromi Ishibashi
Journal: Hepatology (2000)

The anti-mitochondrial antibody response in primary biliary cirrhosis (PBC) is primarily directed at E2 components of PDC, OGDC, and BCOADC, and E3BP. Previous work has shown that the immunodominant autoreactive T- cell epitope is the PDC-E2 163-176 peptide, restricted by HLA DR53. To address molecular mimicry and cross-recognition among mitochondrial autoantigens, we analyzed reactivity, including agonism and antagonism assays, to a series of single amino acid-substituted peptides using cloned T-cell lines in PBC and controls. Interestingly, fine specificities were unique for every single T-cell clone, but the clones could be categorized into two distinct groups based on recognition motifs of the T-cell receptor (TCR) ligand: group A (170)ExDK(173) and group B (168)EIExD(172). (170)E is the most critical TCR contact residue for both groups of cloned T-cell lines, whereas (173)K and (168)E are the critical TCR contact residues for group A and group B cloned T-cell lines, respectively. More importantly, some group A-cloned T-cell lines cross-reacted to human E3BP 34-47, human OGDC-E2 100-113, and several peptides derived from various microbial proteins carrying an ExDK motif, whereas group B-cloned T-cell lines reacted only to E3BP 34-47 carrying an EIExD motif. Furthermore, an RGxG motif was exclusively found in the complementarity-determining region (CDR3) of the TCR Vbeta in the group B-cloned T-cell lines, while G, S, and/or R were frequently found in the CDR3 of the TCR Vbeta in the group A-cloned T-cell lines. These data provide a framework for understanding molecular mimicry among mitochondrial antigens.
Cosmetic Eye Shadow Mimicking Orbital Calcification
Authors: Walter H. Forman
Journal: JAMA (1977)

<h3>To the Editor.—</h3> Orbital calcification is usually of two types, metastatic or dystrophic. The first is seen with abnormalities in calcium and phosphate metabolism, while the latter is caused by calcification within damaged tissues such as tumors, inflammation, infarcts, trauma, or degeneration. Calcifications may be intraocular or extraocular. When seen roentgenographically, some of the deposits are so typical as to suggest a correct cause, while others are less specific. Of more importance is the fact that calcification within the orbit is almost always abnormal and deserves further evaluation.<sup>1</sup>Because of this, we present a case of pseudocalcification of the orbit, which could initiate a long, needless workup. <h3>Report of a Case.—</h3> A 16-year-old girl came to Keesler Air Force Base Hospital with a two-month history of increasing headaches. The pain was described as "retro-ocular" and at times became so intense that "spots appeared before her eyes." Her past medical
Trends in cause specific mortality across occupations in Japanese men of working age during period of economic stagnation, 1980-2005: retrospective cohort study
Authors: K. Wada, N. Kondo, S. Gilmour, Y. Ichida, Y. Fujino, T. Satoh, K. Shibuya
Journal: BMJ (2012)

<b>Objective</b> To assess the temporal trends in occupation specific all causes and cause specific mortality in Japan between 1980 and 2005. <b>Design</b> Longitudinal analysis of individual death certificates by last occupation before death. Data on population by age and occupation were derived from the population census. <b>Setting</b> Government records, Japan. <b>Participants</b> Men aged 30-59. <b>Main outcome measures</b> Age standardised mortality rate for all causes, all cancers, cerebrovascular disease, ischaemic heart disease, unintentional injuries, and suicide. <b>Results</b> Age standardised mortality rates for all causes and for the four leading causes of death (cancers, ischaemic heart disease, cerebrovascular disease, and unintentional injuries) steadily decreased from 1980 to 2005 among all occupations except for management and professional workers, for whom rates began to rise in the late 1990s (P&lt;0.001). During the study period, the mortality rate was lowest in other occupations such as production/labour, clerical, and sales workers, although overall variability of the age standardised mortality rate across occupations widened. The rate for suicide rapidly increased since the late 1990s, with the greatest increase being among management and professional workers. <b>Conclusions</b> Occupational patterns in cause specific mortality changed dramatically in Japan during the period of its economic stagnation and resulted in the reversal of occupational patterns in mortality that have been well established in western countries. A significant negative effect on the health of management and professional workers rather than clerks and blue collar workers could be because of increased job demands and more stressful work environments and could have eliminated or even reversed the health inequality across occupations that had existed previously.
Ventricular Tachyarrhythmia and Psychological Stress
Authors: Stephen T. Sinatra
Journal: JAMA (1987)

<h3>To the Editor.—</h3> Brodsky et al<sup>1</sup>should be congratulated for a fine presentation revealing the connection between psychological stress and life-threatening arrhythmia. They raise a crucial issue: some individuals with complex ventricular arrhythmia in the setting of emotional stress and high sympathetic tone are at risk for sudden cardiac death regardless of the presence of coronary artery disease or the status of their left ventricular function. βBlockers appear to be cardioprotective for patients in this subset. The reasons why some individuals respond to psychological stress with malignant arrhythmia are both unclear and provocative. There is a connection between emotional stress and cardiac vulnerability. Behavioral response to stress and subsequent neuroendocrine response to emotion will eventually occur in susceptible individuals, but sensitivity to emotion is variable. Some individuals prone to cardiovascular disorders probably have in their character an oversensitivity to emotional arousal, psychological conflict, or personal loss. Such arousal can
Routine Chest Radiography after Thoracentesis
Authors: Steven M. Brown
Journal: Annals of Internal Medicine (1997)

Letters15 March 1997Routine Chest Radiography after ThoracentesisSteven M. Brown, MDSteven M. Brown, MDMilwaukee, WI 53211Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-126-6-199703150-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Doyle and colleagues [1] raise important points in their report on the necessity of chest radiography after thoracentesis. However, I think that this report may be misleading. Chest radiography is done after thoracentesis for reasons other than determining whether a pneumothorax has occurred.I often obtain a chest radiograph after evacuation of a large pleural effusion, particularly if I believe that I have removed most of the fluid. The evacuation of fluid may reveal a lung mass that had been masked by the effusion. Removal of pleural fluid can occasionally lead to a condition in which the ...REFERENCE1. Doyle JJ, Hnatiuk OW, Torrington KG, Slade AR, Howard RS. Necessity of routine chest roentgenography after thoracentesis. Ann Intern Med. 1996; 124:816-20. Google Scholar Author, Article, and Disclosure InformationAffiliations: Milwaukee, WI 53211 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1997Volume 126, Issue 6Page: 491KeywordsDiagnostic radiologyLesionsLungsPleural effusionThorax Issue Published: 15 March 1997 Copyright & PermissionsCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
PREDICTION OF IMMEDIATE LEFT VENTRICULAR DYSFUNCTION AFTER SUCCESSFUL AORTIC VALVE SURGERY FOR SEVERE AORTIC REGURGITATION: CONVENTIONAL TWO-DIMENSIONAL VERSUS SPECKLE-TRACKING PARAMETERS
Authors: Jeong Yoon Jang, Jong-Min Song, Min Jung Sin, Eun Jeong Lee, Hanul Choi, Jihyun Sohn, Cheol Hyun Chung, Jae Won Lee, Byung Joo Sun, Dae-hee Kim, Duk-Hyun Kang, Jae-Kwan Song
Journal: Journal of the American College of Cardiology (2014)
THE EXCRETION OF AMMONIA AND TITRATABLE ACID IN NEPHRITIS
Authors: D. D. Van Slyke, G. C. Linder, Alma Hiller, L. Leiter, J. F. McIntosh
Journal: Journal of Clinical Investigation (1926)

As the result of past metabolic studies, especially those of Hender- son and Palmer (12) it is known that the non-volatile acids produced in excess of fixed base by human metabolism are excreted in the urine in two forms, viz., as free acids, and as ammonium salts.Since the kidney is unable to form urine with a pH much lower than 5.0, it can excrete, in significant amounts, free acids of only the weak buffer type.In this class fall acid phosphates and the various organic adds.It appears, however, that free acid excretion may assist also in elimination of strong acids, which can react with buffer salts (e.g., HC + Na2HPO4 = H(NaHPO4) + NaCl), the free buffer acid being excreted in place of the strong acid.Thus Marriott and Howland (19) found that HCl ingestion increased the output of free buffer acids.Ammonia serves to neutralize either weak or strong acids.Con-
Limb lymphoedema in rheumatoid arthritis.
Authors: A Bamji
Journal: Annals of the Rheumatic Diseases (1991)

Limb lymphoedema in rheumatoid arthritisSir: There is an alternative, and simpler, explanation for limb lymphoedema in rheumatoid arthritis as reported by Dacre, Scott, and Huskisson'-obstruction.The report by Macfarlane and van der Linden2 hints at this; oedema in their case was associated with a leaking olecranon bursa, but 'after injection of corticosteroid into the bursa and elevation of the arm the forearm swelling resolved almost completely'.I have seen four cases of severe limb oedema in inflammatory arthritis.
More Studies Pending of Low-Dose Radiation
Authors: Charles Marwick
Journal: JAMA (1990)

WORKERS in the 17 US Department of Energy's nuclear plants around the country are not the only sources of data on the health effects of low-dose radiation exposure (<i>JAMA.</i>1990;264:553-557). Those who live near these plants or work in other kinds of nuclear facilities are also candidates for study. This approach in the United States has been prompted in part by the experience in Britain. A series of clusters that involve small numbers of cases of leukemia has been reported there, occurring in several areas where nuclear facilities are located. One of these British studies is making news at the moment. It suggests that, while the risk of childhood leukemia was found (in various studies) to be unrelated to various measures of environmental contamination from the nuclear plant at Sellafield in northwest England, there was a slightly increased risk of leukemia if the fathers of the children with leukemia were