tbuckley/cabot-search huggingface dataset:
Abstract 2687: Krüppel-like factor 8 targets matrix metalloproteinase-14 to promote breast cancer invasion and metastasis .
Authors: Heng Lu, Liu Hu, Lin Yu, Xianhui Wang, Chao Shen, Tianshu Li, Debarati Mukherjee, Satadru Lahiri, Melissa Wason, Jihe Zhao
Journal: Cancer Research (2013)

Abstract Krüppel-like factor 8 (KLF8) regulates critical gene transcription and invasion events associated with cancer, including epithelial to mesenchymal transition (EMT) and extracellular matrix degradation. Here, we report a novel KLF8-to- matrix metalloproteinase-14 (MMP14) signaling that promotes human breast cancer cell EMT, invasion and metastasis. Cell-surface protein biotinylation and streptavidin pull-down showed that overexpression of KLF8 induced cell-surface accumulation of MMP14 in MCF-10A cells in a FAK-dependent manner, which was correlated with increased MMP14 activity and the ectodomain shedding of E-cadherin. On the other hand, knockdown of KLF8 in MDA-MB-231 cells reduced expression and activity of MMP14 on the cell surface. Promoter reporter assays and chromatin and oligonucleotide precipitations determined that KLF8 activated the human MMP14 gene promoter both directly and indirectly via beta-catenin. Importantly, Matrigel invasion assays showed that MMP14 was required for the KLF8-induced MCF-10A cell invasion in vitro. Experiments using nude mice demonstrated that MMP-14 overexpression downstream of KLF8 in the MDA-MB-231 cells makes a significant contribution to the invasion and angiogenesis in the local primary tumors and lung metastasis. Taken together, this work identified a novel role and mechanisms for MMP14 downstream of KLF8 in the progression of breast cancer metastasis. Citation Format: Heng Lu, Liu Hu, Lin Yu, Xianhui Wang, Chao Shen, Tianshu Li, Debarati Mukherjee, Satadru Lahiri, Melissa Wason, Jihe Zhao. Krüppel-like factor 8 targets matrix metalloproteinase-14 to promote breast cancer invasion and metastasis . [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2687. doi:10.1158/1538-7445.AM2013-2687
Racism continues among doctors in Europe
Authors: H K Khan
Journal: BMJ (1998)

Editor—Last year Ismail and Carnall highlighted the positive attitude of the British in bringing racism in the NHS to worldwide attention.1 Similar coverage by Deutsches Arzteblatt , the medical and political organ of the BundesArztekammer (the German medical association) in Germany, would be unthinkable. Such discussions on race issues would be embarrassing.

I was a target of racial abuse from an overbearing consultant in a hospital in Nordrhein-Westphalia for about two years. He was fully supported …
UK obstetricians face redundancy
Authors: L. Beecham
Journal: BMJ (1999)

Over 350 obstetricians and gynaecologists could be made redundant by the NHS because of changes in hospital training and the lack of manpower planning. This would waste up to £35m ($56m) spent on their training.

The BMA has warned that by May 2001 there will be an additional 500 specialists with the certificate of completion of specialist training in obstetrics and gynaecology to fill an estimated 50 consultant posts a year. At …
Important Role of Endogenous Hydrogen Peroxide in Pacing-Induced Metabolic Coronary Vasodilation in Dogs In Vivo
Authors: Toyotaka Yada, Hiroaki Shimokawa, Osamu Hiramatsu, Yoshiro Shinozaki, Hidezo Mori, Masami Goto, Yasuo Ogasawara, Fumihiko Kajiya
Journal: Journal of the American College of Cardiology (2007)
New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it
Authors: Heather A. Ferris, C. Ronald Kahn
Journal: Journal of Clinical Investigation (2012)

Glucocorticoids are a powerful tool used to treat a range of human illnesses, including autoimmune diseases and cancer, and to prevent rejection following organ transplantation. While lifesaving for many, they come with a steep price, often leading to obesity, insulin resistance, diabetes, and osteoporosis. In this issue of the JCI, Brennan-Speranza and colleagues provide evidence that the osteoblast-derived peptide osteocalcin is one of the drivers of the metabolic derangements associated with glucocorticoid therapy. This novel mechanism could open up new avenues for the treatment of these disorders.
Drugs Five Years Later
Authors: STEPHEN M. KRANE
Journal: Annals of Internal Medicine (1982)

Control of Paget's disease of bone has been possible through treatment with agents that decrease bone resorption; calcitonins, diphosphonates, and mithramycin. The pagetic lesion is not, however, cured. Etidronate disodium is one of the diphosphonates. The clinical improvement attained with this drug has to be set against adverse effects, of which pain is probably the most bothersome in practice. Clinical remission can last as long as 2 years after treatment is stopped.
Iso-immunization by the Blood Factor N
Authors: L. de Kromme, L. A. M. van der Spek
Journal: BMJ (1948)

The collection of 440 ml. of blood and the reinfusion of this citrated blood were performed on 324 individuals.An infusion of 540 ml. of glucose-saline was given to 56 individuals.Febrile reactions occurred in nine of the 324 infusions of blood, but in none of the infusions of glucose-saline.The causes of these reactions are elucidated.Febrile reactions are no more common with stored blood than with fresh blood, provided the blood is cleanly collected and properly stored.The effect of the temperature and the rate of administration of the infused fluid on reactions are described.Venous spasm, thrombosis, and mild vasovagal features were observed in a few cases.The avoidance of pyrexial reactions and the cause of rigors associated with rapid infusions are discussed.These observations were made during the routine training of trans- fusion orderlies, and we thank our commanding officer, Brigadier Sir Lionel Whitby, for his great interest and help in the training of personnel in transfusion and resuscitation.
Abstract 1756: Automated digital analysis of interleukin-6 (IL-6) expression in a prostate cancer (PCa) matched case-control outcome based tissue microarray (TMA) design set
Authors: Jarna Shah, Virgilia Macias, Marisa del Mundo-Galicia, Mark Xue, Andre A. Kajdacsy-Balla
Journal: Cancer Research (2010)

Abstract IL-6 is a multifunctional cytokine that has been involved in modulation of growth and differentiation in several malignant tumors. Studies have shown its role as an important autocrine growth factor for androgen-dependent human prostate cancer in vivo. Serum IL-6 has also been associated with poor prognosis in prostate cancer. We performed a digital analysis of IL-6 immunoreactivity in prostate cancer epithelial cells to determine differences in IL-6 expression between recurrence and non-recurrence groups in a PCa nested case-control cohort. We analyzed an outcome-based TMA obtained from the Cooperative Prostate Cancer Tissue Resource (CPCTR) containing quadruplicate cores (0.6mm core diameter) from 200 pairs of PCa tumor samples (n=400). Cases with PSA recurrence were matched 1:1 with cases without recurrence by race, age, year of surgery, Gleason grade, and pathological stage. All cases had at least five-years follow up. TMA slides were incubated with rabbit polyclonal IL-6 antibody (Abcam) in a 1:600 dilution. Expression levels of IL-6 were assessed by Colocalization Algorithm (ScanScope®, Aperio Corp). Differences in IL-6 intensity between case-control pairs were calculated by Wilcoxon signed rank paired test. Automated data was available for analysis in 149 pairs (n=298). The Wilcoxon signed rank test showed no statistically significant differences in IL-6 intensity between the two groups (p = 0.7). To the best of our knowledge, this is the first study to examine the expression of IL-6 in a large PCa TMA set. Our results revealed IL-6 expression in cancer tissue; however, after statistical analysis, no significant differences were obtained to indicate that IL-6 may be considered as prognostic marker of prostate cancer with biochemical recurrence if cases were first matched by race, age, date of prostatectomy, Gleason score, and stage. In our study we excluded stromal and inflammatory cells IL-6 expression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1756.
Abnormal lymphocyte function following long-term PUVA therapy for psoriasis
Authors: W.L. MORISON, J. WIMBERLY, J.A. PARRISH, K.J. BLOCH
Journal: British Journal of Dermatology (1983)

Journal Article Abnormal lymphocyte function following long‐term PUVA therapy for psoriasis Get access W.L. MORISON, W.L. MORISON Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar J. WIMBERLY, J. WIMBERLY Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar J.A. PARRISH, J.A. PARRISH Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, U.S.A. Dr J.A.Parrish, Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar K.J. BLOCH K.J. BLOCH Clinical Immunology and Allergy Units of the Medical Services, Massachusetts General Hospital, Boston, Massachusetts 02114, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 108, Issue 4, 1 April 1983, Pages 445–450, https://doi.org/10.1111/j.1365-2133.1983.tb04597.x Published: 01 April 1983 Article history Accepted: 10 August 1982 Published: 01 April 1983
Validation of a stopping rule at week 12 using HBsAg and HBV DNA for HBeAg-negative patients treated with peginterferon alfa-2a
Authors: Vincent Rijckborst, Bettina E Hansen, Peter Ferenci, Maurizia R Brunetto, Fehmi Tabak, Yilmaz Cakaloglu, A Galeota Lanza, Vincenzo Messina, Claudio Iannacone, Benedetta Massetto, Loredana Regep, Massimo Colombo, Harry L A Janssen, Pietro Lampertico
Journal: Journal of Hepatology (2012)
Patients' access to their own psychiatric records.
Authors: M Bernadt, L Gunning, M Quenstedt
Journal: BMJ (1991)

9 Office of Population Censuses and Surveys. Classification of occupations, 1980. London: HMSO, 1980. 10 McCullagh P, Neider JA. Generalized linear models. London, New York: Chapman and Hall, 1983. 11 Baker RJ, Neider JA. The GLIM system: release 3.77. Oxford: Numerical Algorithms Group, 1978. 12 Aitkin M, Anderson D, Francis B, Hinde J. Statistical modelling in GLIM. Oxford: Oxford University Press, 1989. 13 Wilcox AJ, Russell IT. Birthweight and perinatal mortality. III. Towards a new method of analysis. IntJ Epidemiol 1986,15:188-%. 14 Morris JN, Heady JA. Social and biological factors in infant mortality. V. Mortality in relation to the father's occupation, 1911-50. Lancet 1955;i: 554-60. 15 Pharoah POD, Morris JN. Postneonatal mortality. Epidemiol Rev 1979;1: 170-83. 16 Brooke OG, Anderson HR, Bland JM, Peacock JL, Stewart CM. Effects on birth weight of smoking, alcohol, caffeine, socioeconomic factors, and psychosocial stress. BMJ 1989;298:795-801. 17 Malloy MH, Kleinman JC, Land GH, Schramm WF. The association of maternal smoking with age and cause of infant death. Am J Epidemiol 1988;128:46-55.
1420 ASUNAPREVIR WITH PEGINTERFERON-ALFA AND RIBAVIRIN IN TREATMENT-NAIVE PATIENTS WITH GENOTYPE-1 OR -4 CHRONIC HEPATITIS C: SVR24 RESULTS FROM A RANDOMIZED PHASE 2B STUDY (AI447016)
Authors: J.-P. Bronowicki, V. Ratziu, A. Gadano, P.J. Thuluvath, F. Bessone, C.T. Martorell, S. Pol, R. Terg, Z. Younes, B. He, T. Eley, D. Cohen, P. Mendez, E.A. Hughes
Journal: Journal of Hepatology (2013)
Cutaneous sarcoid-like granulomas in primary immunodeficiency disorders
Authors: T.S. LEVINE, A.B. PRICE, S. BOYLE, A.D.B. WEBSTER
Journal: British Journal of Dermatology (1994)

Summary We report the occurrence of cutaneous sarcoid-like granulomas in one patient with common variable immunodeficiency and another with 'thymoma and hypogammaglobulinaemia". To our knowledge, this is the first time that such skin lesions have been described in patients with primary immunodeficiency. These granulomas may be attributed to a combination of interleukin-2 deficiency and a profound CD4 lymphopenia. The lesions are similar to the non-infectious 'papular eruption' associated with human immunodeficiency virus infection, and might reflect a common pathogenic mechanism.
Symptom patterns in functional dyspepsia and irritable bowel syndrome: relationship to disturbances in gastric emptying and response to a nutrient challenge in consulters and non-consulters
Authors: S Haag
Journal: Gut (2004)

Our aim was to assess the relationship between gastric motor and sensory function and symptom patterns in community subjects and patients with functional dyspepsia (FD) or irritable bowel syndrome (IBS).We recruited 291 asymptomatic blood donors, 151 symptomatic blood donors (recurrent abdominal pain or discomfort), and 40 patients with FD or IBS. Abdominal symptoms were assessed using the bowel disease questionnaire (BDQ) and, in addition, the most bothersome symptom complex identified (dysmotility-type, ulcer-type dyspepsia, or IBS). Gastric emptying time (GET (t(1/2), min)) was measured by (13)C-octanoic breath test and a nutrient challenge performed. Twenty randomly selected asymptomatic blood donors, 48 symptomatic blood donors (30 FD, 18 IBS), and 40 patients (23 FD, 17 IBS) had additional function testing.GET (t(1/2)) was significantly (p<0.05) longer in blood donors with FD symptoms (99 (6) min) and FD patients (110 (12) min) compared with asymptomatic controls (76.7 (7) min), but was not significant in IBS blood donors or patients. Overall, 25 of 48 blood donors with symptoms and 18 of 40 patients had slow gastric emptying. GET was most delayed in subjects with predominantly dysmotility-type symptoms (167 (36) min v controls; p<0.01). Symptom intensities after a nutrient challenge were significantly higher in FD patients and symptomatic blood donors compared with asymptomatic controls; 14 of 48 blood donors with symptoms and 16 of 40 patients had a symptom response to the nutrient challenge exceeding the response (mean (2SD)) of healthy asymptomatic controls.Gastric emptying and the global symptom response to a standardised nutrient challenge are abnormal in population based (non-health care seeking) subjects with dyspepsia.
Anticoagulation for venous thromboembolism
Authors: John W Eikelboom, Jeffrey S Ginsberg, Jack Hirsh
Journal: BMJ (2007)

<h3>OBJECTIVE:</h3> To assess the presentation, different surgical modalities and their outcome in the treatment of polycystic ovarian disease. <h3>METHODS:</h3> A retrospective study was carried out on 66 patients with polycystic ovarian disease. The majority of the cases had a history of infertility for at least 2 years and were known to be clomiphene citrate resistant in the Saudi German Hospital, Jeddah between 1994 and 1998 undergoing laparoscopic ovarian drilling. <h3>RESULTS:</h3> More than 80% of the patients were below 30 years of age. The majority of cases below 30 years had primary infertility. Irregular cycle was the main clinical presentation in 75% of cases; ovarian volume was more than 5.5cm3 in all of the cases. Diathermy drilling was carried out for 50 patients, laser for 12 patients and wedge resection for 4 patients. The follow-up treatment showed that pregnancy rate was 23%, 38% and 0% in the 3 groups. Cases that failed to conceive had significantly higher luteinizing hormone level. <h3>CONCLUSION:</h3> Laparoscopic ovarian drilling using diathermy or laser is effective during the induction of ovulation and increases the pregnancy rate in cases of polycystic ovarian disease resistant to clomiphene citrate.
REQUESTS FOR REPRINTS
Authors: J. P. Greenhill
Journal: JAMA (1942)

To the Editor:—  I fully support the statements made by Dr. Richard Kovacs in his recent communication inThe Journal. Very few physicians who ask for reprints enclose a stamped envelop with their request. However, there is an additional and more flagrant lack of courtesy. Many physicians write to ask for information on how to treat patients and data for papers they intend to write. My impression is that less than one in ten takes the trouble to  us for the advice and information we give, even when we specifically ask to be told of the results of therapy we recommend. It seems to me that the least physicians can do is to say thank you for the time we spend thinking about their problems and preparing an answer.
743 The majority of patients with HBeAg-negative chronic hepatitis B treated with peginterferon alpha-2a (40KD) [PEGASYS®] sustain responses 2 years post-treatment
Authors: P. Marcellin, E. Bonino, G.K.K. Lau, P. Farci, C. Yurdaydin, T. Piratvisuth, R. Jin, S. Gurel, S. Hadziyannis, Z.-M. Lu, M. Popescu
Journal: Journal of Hepatology (2006)
Heterogeneous Increase in CD34-positive Alveolar Capillaries in Idiopathic Pulmonary Fibrosis
Authors: Masahito Ebina, Minoru Shimizukawa, Naoko Shibata, Yuichiro Kimura, Takashi Suzuki, Mareyuki Endo, Hironobu Sasano, Takashi Kondo, Toshihiro Nukiwa
Journal: American Journal of Respiratory and Critical Care Medicine (2004)

To elucidate the apparent contradictions in vascular remodeling in the lungs of patients with idiopathic pulmonary fibrosis, we evaluated alveolar vascularity in relation to the various degrees of fibrosis in surgically biopsied lungs of usual interstitial pneumonia. Alveolar capillary endothelial cells were intensely immunoreactive with CD34 but not with von Willebrand factor. Vascular density, that is, the relative ratio of capillary area to total area of alveolar walls, was significantly higher at low grades of fibrosis than in control lungs, whereas vascular density gradually decreased as the degree of fibrosis increased and was lower than that of control lungs in the most extensively fibrotic lesions. No vessels were observed inside fibroblastic foci. The potent angiogenic factors vascular endothelial growth factor and interleukin-8 were abundantly produced by capillary endothelial cells and alveolar epithelial cells in highly vascularized alveolar walls. In contrast, venules with CD34-negative but von Willebrand factor-positive endothelial cells localized in the center of the fibrotic lesions were slightly increased and identified as postcapillary venules by three-dimensional reconstructed images. These results indicate the presence of heterogeneous vascular remodeling in usual interstitial pneumonia.
Improving reproductive performance in overweight/obese women with effective weight management
Authors: R. J. Norman
Journal: Human Reproduction Update (2004)

Obesity and overweight are common conditions in the developed countries and they carry many health consequences, including some reproductive disorders. There is a very high prevalence of obese women in the infertile population and many studies have highlighted the link between obesity and infertility. A large proportion of infertile women have polycystic ovary syndrome (PCOS) which is also linked with increased risk of obesity and other metabolic anomalies. The association between obesity and/or PCOS and hyperinsulinaemia, hyper androgenism and abnormal secretion of other hormones, such as leptin, underlies many reproductive disorders observed in this population. It has been demonstrated that weight loss can improve the fertility of obese women through the recovery of spontaneous ovulation, whereas others will have improved response to ovarian stimulation in infertility treatment. Therefore, it is proposed that following the initial assessment of infertility and body mass index or other measurement of obesity, various weight management interventions, including diet, exercise or pharmacotherapeutic approaches, should be considered for overweight and obese infertile women.
Long-Term Prognostic Value of Dobutamine Stress CMR
Authors: Sebastian Kelle, Amedeo Chiribiri, Juliane Vierecke, Christina Egnell, Ashraf Hamdan, Cosima Jahnke, Ingo Paetsch, Ernst Wellnhofer, Eckart Fleck, Christoph Klein, Rolf Gebker
Journal: JACC. Cardiovascular imaging (2011)
Senses and Lifespan
Authors: Carolyn J. Hildreth
Journal: JAMA (2009)

Scientists studying the roundworm Caenorhabditis elegans found that the anticonvulsant drug ethosuximide delays age-related changes and extends the animal's lifespan by inhibiting certain chemosensory neurons (Collins JJ et al. PLoS Genet. 2008;4[10]:e1000230).
Branding treatment of children in rural India should be banned
Authors: B Adhisivam, Roy Gowtham
Journal: BMJ (2005)

Learning from low income countries Experience in low income countries should count towards specialist registrar trainingEditor-Richards and Tumwine ask for discussion on the subject of poor countries making the best teachers. 1When will the postgraduate tutors and royal colleges recognise that medical experience in developing countries should be counted towards specialist registrar training?I recently spoke to a specialist registrar whose 12 months in the main teaching hospital in Malawi counted for nothing towards his training.As a specialist registrar training in chest medicine, he will have seen more tuberculosis than most chest physicians working in provincial England will see in a lifetime.This is particularly frustrating as the numbers of cases of tuberculosis are rising progressively in the United Kingdom, and training in the diagnosis and management of this disease needs to be improved as much as possible.
A call for convalescence
Authors: T. Dalrymple
Journal: BMJ (2012)

In theory I am in favour of idleness, for without it there can be no contemplation, and without contemplation there can be no wisdom. But good as I was in my youth at being idle, I now find it difficult in practice to be idle. There is, besides, the difficult question of just how idle one should be, and for how much of the time; like many a joy, that of idleness quickly palls.

Can there be any idler pleasure than leafing through second hand books? I picked up a small volume recently while doing so called How to Be Idle , by a philosopher of idling and founder of the Idler magazine, Tom Hodgkinson. …
Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations
Authors: Konstanze Döhner, Richard F. Schlenk, Marianne Habdank, Claudia Scholl, Frank G. Rücker, Andrea Corbacioglu, Lars Bullinger, Stefan Fröhling, Hartmut Döhner
Journal: Blood (2005)
The Significance of Fragmented QRS Complex in Left Bundle Branch Block
Authors: Nermin Bayar, Şakir Arslan, Zehra Erkal, İsa Öner Yüksel, Erkan Köklü, Deniz Demirci, Selçuk Küçükseymen, Görkem Kuş, Murat Esin
Journal: Journal of the American College of Cardiology (2013)
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Authors: Saul A Villeda, Kristopher E Plambeck, Jinte Middeldorp, Joseph M Castellano, Kira I Mosher, Jian Luo, Lucas K Smith, Gregor Bieri, Karin Lin, Daniela Berdnik, Rafael Wabl, Joe Udeochu, Elizabeth G Wheatley, Bende Zou, Danielle A Simmons, Xinmin S Xie, Frank M Longo, Tony Wyss-Coray
Journal: Nature Medicine (2014)