tbuckley/cabot-search huggingface dataset:
A CASE OF DESTRUCTIVE FOLLICULITIS OF THE SCALP IN A PATIENT AFFECTED WITH HEREDITARY SYPHILIS
Authors: J. F. PAYNE
Journal: British Journal of Dermatology (1895)

THE following case is one of a somewhat rare disease, which was first described by Quinquaud as Folliculitis decalvans or epilatoria, but here also complicated with more diffuse inflammation.I n this case the history unmistakably proved, as will be seen, that inherited syphilis was the exciting cause; but whether this is also true of other cases of the disease I do not undertake to say.Quinquaud exhibited a case of this disease to the weekly meeting of the physicians of the St. Louis Hospital on December 13th, 1888; and on that occasion I find that Pournier stated he had seen a similar case in B young girl, which was due to hereditary syphilis.*Before this, apparently, Quinquaud had communicated a paper to the "Bulletin de la Sociitte Medicale des Hopitaux" in 1888.tHe had also placed a coloured model of the affection in the museum of the Hospital of St. Louis in 1887 (Catalogice iles M o u l a p s , No. 1293).The affection has since then been frequently discussed, especially in the French journals.It is mentioned in Dr. Radcliffe-Crocker's and Mr. Malcolm Morris's works on diseases of the skin.
Low free testosterone levels in rheumatoid arthritis.
Authors: T D Spector, L A Perry, G Tubb, A J Silman, E C Huskisson
Journal: Annals of the Rheumatic Diseases (1988)

The androgen status of 25 male patients with rheumatoid arthritis (RA) was assessed and compared with that of age matched controls with osteoarthritis (OA). Significantly reduced levels of serum free testosterone were found in the RA group. Within that group free testosterone was unrelated to all indices of disease activity measured, though it was strongly related to latex positivity. These results support the hypothesis that male sex hormones may have a protective role in RA, though prospective studies would be necessary to determine whether the relation was one of cause or effect.
Case 5-1961
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. Kibbee
Journal: New England Journal of Medicine (1961)

Presentation of Case A sixty-one-year-old housewife was admitted to the hospital because of anemia. The patient had been anemic for many years and was treated occasionally with iron given orally. There was no known bleeding since an episode of mild menorrhagia during the year before the menopause, eleven years before entry. She had never received blood transfusions, liver extract or vitamin B12. The condition of her teeth had been bad for a long time. For several months before admission she felt intermittently feverish. One year before entry she weighed 117 pounds. There was an episode of jaundice thirty-seven years previously. . . .
Atypical Thymoma (World Health Organization Type B3) with Neuroendocrine Differentiation Combined with Hyperparathyroidism
Authors: Hyun Sik Park, Sang Wha Lee, Seon Ung Yun, Byeong Joo Bae, Hye Jin Choi, So Young Kim, Hae Jin Choi, Wan Seop Kim, Hee Joung Kim, Kye Young Lee
Journal: Journal of Thoracic Oncology (2010)
Literature and Medicine
Authors: Robert Coles
Journal: JAMA (1986)

In recent years an increasing number of medical schools have begun to offer medical students an opportunity to reflect upon the nature of their future work with the help of what I used to hear Dr William Carlos Williams keep calling "the novelist's angle of vision." What did he mean when he used that phrase? He offered this explanation one day, in the last decade of his life, to a medical student who had crossed the Hudson river to visit him yet again: The abstract, categorical mind can be wonderful—the glory of the intellect at work, coming to its great big (and big-deal!) conclusions. But we've got to keep a close check on all that—the head running away with itself. The doctor treating a patient out there on the frontline falls back on himself, his own manner of being with people—and he has to come to terms with not only
Novel Protein Transduction Domain Mimics as Nonviral Delivery Vectors for siRNA Targeting NOTCH1 in Primary Human T cells
Authors: A. Özgül Tezgel, Gabriela Gonzalez-Perez, Janice C. Telfer, Barbara A. Osborne, Lisa M. Minter, Gregory N. Tew
Journal: Molecular Therapy (2012)

RNA interference technology has recently been highlighted as a powerful research method as well as a potential therapeutic treatment for several diseases. However, the delivery of small interfering RNA (siRNA) into T cell lines and primary blood cells is exceedingly challenging, as they are resistant to transfection by conventional reagents. As a result, there is an unmet need for nonviral, efficient, and easily prepared carriers for siRNA delivery into hard-to-transfect cell types. Here, we report a novel system based on protein transduction domain mimics (PTDMs), generated by ring opening metathesis polymerization, for intracellular delivery of siRNA molecules. PTDM-based siRNA delivery induced efficient NOTCH1 knockdown in Jurkat T cells and human peripheral blood mononuclear cells without any measured toxicity. Furthermore, delivering siRNA to NOTCH1 in human peripheral blood cells modulated cell proliferation and differentiation of T cells into T(H)1 cells.
A Copper 7 IUCD with no copper.
Authors: M Pollock
Journal: BMJ (1979)

These observations do not detract from the interesting points made by Verbeelen and Fuss with more modern methods, especially the induction of hypercalcaemia on oestrogen withdrawal, as well as of hypocalqaemia on oestrogen administration.They merely indi- cate that the latter phenomenon is a perennial one.
Interleukin-30: A novel antiinflammatory cytokine candidate for prevention and treatment of inflammatory cytokine-induced liver injury
Authors: Denada Dibra, Jeffry Cutrera, Xueqing Xia, Bhaskar Kallakury, Lopa Mishra, Shulin Li
Journal: Hepatology (2011)

The liver is the major metabolic organ and is subjected to constant attacks from chronic viral infection, uptake of therapeutic drugs, life behavior (alcoholic), and environmental contaminants, all of which result in chronic inflammation, fibrosis, and, ultimately, cancer. Therefore, there is an urgent need to discover effective therapeutic agents for the prevention and treatment of liver injury, the ideal drug being a naturally occurring biological inhibitor. Here we establish the role of IL30 as a potent antiinflammatory cytokine that can inhibit inflammation-induced liver injury. In contrast, interleukin (IL)27, which contains IL30 as a subunit, is not hepatoprotective. Interestingly, IL30 is induced by the proinflammatory signal such as IL12 through interferon-gamma (IFN-γ)/signal transducer and activator of transcription 1 signaling. In animal models, administration of IL30 by way of a gene therapy approach prevents and treats both IL12-, IFN-γ-, and concanavalin A-induced liver toxicity. Likewise, immunohistochemistry analysis of human tissue samples revealed that IL30 is highly expressed in hepatocytes, yet barely expressed in inflammation-induced tissue such as fibrous/connective tissue.These novel observations reveal a novel role of IL30 as a therapeutic cytokine that suppresses proinflammatory cytokine-associated liver toxicity.
Seizing the telescope
Authors: T. Delamothe
Journal: BMJ (2015)

Earlier this week the BBC showed a documentary on the short life and sad death of Aaron Swartz, a US internet activist who hanged himself two years ago while under federal indictment for data theft. At issue were academic journal articles that Swartz had downloaded in bulk from JSTOR, a digital depository. A few years earlier, in his “Guerilla Open Access Manifesto” (http://bit.ly/1u1qljq), Swartz had argued, “The world’s entire scientific and cultural heritage, published over centuries in books and journals, is increasingly being digitized and locked up by a handful of private corporations . . . [Scientists need to] ensure their work is published on the Internet, under terms that allow anyone to access it.”

At his funeral Tim Berners-Lee, co-creator of the worldwide web, …
Treating hyperkinetic disorders in childhood
Authors: E. Taylor, R. Hemsley
Journal: BMJ (1995)

British doctors are nowadays more likely to diagnose and treat hyperactivity in children. There are three reasons for the change. Firstly, the International Classification of Diseases, 10th revision (ICD-10) includes a definition of “hyperkinetic disorder” that is more explicit than previous versions.1 The disorder is much more than naughtiness or high energy that overtaxes weary or depressed parents. Its essential characteristics are persistent traits of severe and pervasive inattentiveness, overactivity, and impulsiveness, beginning in the first five years of life. Centres that have changed from using ICD-9 to using ICD-10 have already noted that the diagnosis is being made more often.2

Secondly, pressure from parents' support groups has forced increased professional recognition. Private clinics, often promoted direct to the public, have been set up to diagnose “attention deficit-hyperactivity disorder.” Some prescribe methylphenidate and other stimulant drugs in the North American way; others concentrate on advice about diet and allergies. Thirdly, methylphenidate has recently been made generally available in Britain after some years on a named patient basis.

In the light of these trends should the NHS be providing more specialist services? American and Australian practice is based on the fact that doctors there diagnose attention deficit-hyperactivity disorder very much more commonly than British doctors diagnose hyperkinetic disorder, even when they are all …
The Natural History of Cholelithiasis: The National Cooperative Gallstone Study
Authors: JOHNSON L. THISTLE
Journal: Annals of Internal Medicine (1984)

The National Cooperative Gallstone Study, a doublemasked, placebo-controlled, therapeutic trial of Chenodiol (chenodeoxycholic acid), provided an opportunity to study the natural history of cholelithiasis in patients who choose nonsurgical management. The major component of the study comprised 916 patients, 305 of whom were randomly assigned to receive a placebo for 24 months. Among these 305 patients, the probability of having biliary tract pain during the 24 months of prospective evaluation was significantly increased if the patient had had a history of biliary tract pain in the 12 months before entry into the study (69% versus 31%). Thirty-eight percent of patients had stone growth ( > 0.5 cm3), and 18% had a spontaneous decrease in stone volume. Despite the high incidence of biliary tract pain, nonelective cholecystectomy was required in only 4% of patients during the 24 months.
A common link between aging, schizophrenia, and autism?
Authors: Jocelyn Faubert, Armando Bertone
Journal: Behavioral and Brain Sciences (2004)

Phillips &amp; Silverstein (P&amp;S, 2003) have proposed that NMDA-receptor hypofunction is the central reason for impaired cognitive coordination and abnormal gestalt-like perceptual processing in schizophrenia. We suggest that this model may also be applicable to non-pathological (or normal) aging given the compelling evidence of NMDA-receptor involvement during the aging process that results in age-related change in higher-level perceptual performance. Given that such deficits are present in other neurological disorders such as autism, an argument for a systematic assessment of perceptual functioning in these conditions may be posited.
THE FATE OF BCG AND ASSOCIATED CHANGES IN THE ORGANS OF RABBITS
Authors: Max B. Lurie
Journal: The Journal of Experimental Medicine (1934)

For some time after intravenous inoculation into rabbits the BCG multiplies in various organs of the body. As with more virulent tubercle bacilli, the greater the primary deposition of bacilli the more rapid is their initial growth and the earlier is the beginning of their destruction. Destruction sets in synchronously with the development of definite hypersensitivity to tuberculin. With the smallest deposition destruction begins at once in the lung and liver without preliminary multiplication. However multiplication always takes place in the lymph nodes. It continues here and in the spleen at a time when other organs have acquired sufficient immunity to reduce the number of bacilli considerably. It is seen that the relative susceptibility of the lymphatic tissue is not due to such factors as drainage. Thus the local immunity acquired by the lymph nodes against the BCG is for a time less effective than that developed in the other organs. However by the end of the 4th week, simultaneously with the development of marked hypersensitivity to tuberculin, even these structures acquire sufficient immunity to bring about the all but complete annihilation of the bacilli. Isolated microorganisms persist in the lymph nodes even 14 months after inoculation. These bacilli do not acquire any added virulence because of their long residence in the body. As observed with more virulent strains in previous studies, the growth of the bacilli is associated with a local accumulation of mononuclears into nodules and their multiplication by mitosis, the destruction of the bacilli with the formation of epithelioid and giant cell tubercles. These changes may be extensive and at times involve a large part of the lung and lymph nodes. The secondary invasion of the tubercles by polymorphonuclears, their death, exudation of serum and cells into the alveoli of the lung, and caseation in the lymph nodes occur simultaneously and are synchronous with the development of hypersensitiveness to tuberculin. At this time the presence in the tissues of numbers of bacilli that previously were innocuous to the cells is associated with caseation. It is noteworthy that both caseation and the tuberculin reaction are not elicited in an early stage of the disease, but in a later stage they are induced in response to smaller quantities of bacilli or tuberculin. All the tuberculous changes, including the caseous foci in the lymph nodes, usually resolve completely by the end of the 2nd month after inoculation without leaving any fibrous scars, although perivascular accumulations of mononuclears may still remain. The few bacilli that persist in the lymph nodes after this period cause no tuberculous changes.
Excellent Disease Control and Survival in Patients With Advanced Nasopharyngeal Cancer Treated With Chemoradiation
Authors: Danny Rischin, June Corry, Jennifer Smith, Josephine Stewart, Peter Hughes, Lester Peters
Journal: Journal of Clinical Oncology (2002)

PURPOSE: To determine the efficacy and safety of epirubicin, cisplatin, and infusional fluorouracil (5-FU) chemotherapy followed by radiation with concurrent cisplatin in patients with locally and/or regionally advanced nasopharyngeal cancer. PATIENTS AND METHODS: Thirty-five patients were treated with three cycles of induction chemotherapy with epirubicin 50 mg/m 2 and cisplatin 75 mg/m 2 combined with continuous-infusion 5-FU 200 mg/m 2 daily for 9 weeks, followed by concurrent chemoradiation of 60 Gy in 2-Gy fractions with cisplatin 20 mg/m 2 daily for 5 days in weeks 1 and 6. RESULTS: Median age was 43 years, 74% had World Health Organization type III histology, and 91% had stage IV disease (International Union Against Cancer, ed 4). All patients received three cycles of induction chemotherapy, and 97% completed chemoradiation. The estimated 4-year progression-free survival rate was 81% (95% CI, 59% to 93%), and the estimated 4-year overall survival rate was 90% (95% CI, 74% to 97%). Only two patients have had a locoregional relapse by the close-out date despite the use of only 60 Gy. Induction chemotherapy was well tolerated, with 11% grade 3 or 4 stomatitis, 26% grade 3 vomiting, and no episodes of febrile neutropenia. Acute toxicities of chemoradiation were as follows: 23% grade 3 or 4 vomiting, 6% febrile neutropenia, 31% grade 3 mucositis, and 23% grade 3 skin toxicity. The most prevalent grade 3 late effects were xerostomia and hearing loss. CONCLUSION: This regimen was well tolerated, can be delivered as planned, and has resulted in excellent locoregional disease control and survival in patients with locally advanced nasopharyngeal cancer.
A Second-Opinion Program for Coronary Artery Bypass Graft Surgery
Authors: Sylvain Fribourg
Journal: JAMA (1988)

To the Editor.  —The study by Graboys et al 1 and the accompanying editorial in the same issue of JAMA by McIntosh 2 do not analyze the reactions and actions of the patient facing a second opinion contradictory  the first  The study's authors write of the difficulties confronting a physician providing a second opinion, which, to date, have not been resolved. The editorial's author also comments on the difficulties encountered by the physician rendering a second opinion, adding that this study by Graboys et al should encourage the public  ask more frequently for a second opinion.  It has been my practice for years, as a result of observing the bitter trials experienced by some patients receiving contradictory opinions, whenever I see a patient for a second opinion  preface the medical care activity by a discussion with the patient of the potential dilemma  be faced in
Complexities in Prognostication in Advanced Cancer
Authors: Elizabeth B. Lamont, Nicholas A. Christakis
Journal: JAMA (2003)

Predicting survival and disclosing the prediction to patients with advanced disease, particularly cancer, is among the most difficult tasks that physicians face. With the de-emphasis of prognosis in favor of diagnosis and therapeutics in the medical literature, physicians may have difficulty finding the survival information they need to make appropriate estimates of survival for patients who develop cancer. Quite separate from the challenge of estimating survival accurately, physicians may also find the process of disclosing the prognosis to their patients difficult. Using the vignette of a real patient with advanced cancer who far outlived her physician's prognostic estimate, we discuss clinical issues related to the science of prognosis in advanced cancer and the art of its disclosure.
PSYCHIATRY AND NATIONAL SECURITY
Authors: Zigmond M. Lebensohn
Journal: JAMA (1961)

Recent accounts in the press concerning the two employees of the National Security Agency who defected to the Soviet Union have understandably created a feeling of uneasiness about our entire security program in the minds of the public. The fact that one of the defectors had consulted a psychiatrist shortly before his defection has further confused the picture. As a result, the relationship of the individual patient to his psychiatrist when sensitive agencies are involved has become unclear for many patients undergoing psychiatric treatment, for the medical profession, and for the public at large. It may be useful, therefore, to restate certain basic principles in order to clarify some of the current misconceptions. The first misconception, bluntly stated, is that any employee of a sensitive agency receiving psychiatric treatment is<i>ipso facto</i>a security risk. This is untrue. The truth is that a substantial number of such employees have been
Correlation between Changes in Regional Cerebral Blood Flow and Pain Relief in Complex Regional Pain Syndrome Type 1
Authors: Ching-Tang Wu, Yu-Ming Fan, Chen-Ming Sun, Cecil O. Borel, Chun-Chang Yeh, Chih-Ping Yang, Chih-Shung Wong
Journal: Clinical Nuclear Medicine (2006)

Analyzing changes in regional cerebral blood flow (rCBF) with SPECT in complex regional pain syndrome type 1 (CRPS 1), formerly known as reflex sympathetic dystrophy, is an optimal method for evaluating effective pain relief. We attempted to investigate the correlation of changes in rCBF with pain relief during treatments of sympathetic blockade and multimodal epidural pain control.We describe a patient with severe CRPS 1 in whom conventional treatment failed to relieve the pain. Combined repeated lumbar sympathetic blocks and long-term epidural morphine, bupivacaine, and ketamine administration provided satisfactory pain relief and functional activity recovery. Six normal control subjects having one Tc-99m HMPAO scan each and the patient with CRPS having 3 Tc-99m HMPAO scans (once before treatment and twice at 4 months and 6 months after treatment, respectively). The patient with CRPS showed lower rCBF than normal controls in the left thalamus and higher rCBF than normal controls in the right parietal lobe and left frontal lobe. After subsequent treatment, the subtraction images showed increased rCBF in the left thalamus and decreased rCBF in the right parietal and left frontal lobes.Tc-99m HMPAO SPECT showed a relationship of rCBF in the thalamus, parietal lobe, and frontal lobe with pain relief. rCBF alterations may provide an indicator for the quality of pain management for neuropathic pains. Subtraction analysis between pre- and posttreatment, by using statistical parametric mapping (version 2), can be used as an objective indicator for the effectiveness of therapy.
Charter on Medical Professionalism: Putting the Charter into Practice
Authors: Walter J. McDonald
Journal: Annals of Internal Medicine (2003)

Letters20 May 2003Charter on Medical Professionalism: Putting the Charter into PracticeWalter J. McDonald, MDWalter J. McDonald, MDAmerican College of Physicians; Philadelphia, PA 19106 (McDonald)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-10-200305200-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We certainly agree with Mr. Feldman that the medical system aspires to excellent quality. The stimuli for creating the charter, however, included the difficulty that many have in accessing that quality and the recognition that the quality can be improved. In addition, the complexity of the system has created the potential for us to lose sight of the primacy of patient welfare and the principle of social justice. Mr. Feldman also says that he would like to see the charter refer to a commitment by physicians to work in partnership with administrators to improve the integrity and quality ... Author, Article, and Disclosure InformationAffiliations: American College of Physicians; Philadelphia, PA 19106 (McDonald) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMedical Professionalism in the New Millennium: A Physician CharterCharter on Medical Professionalism: Putting the Charter into Practice Steven A. Wartman Charter on Medical Professionalism: Putting the Charter into Practice Jordan J. Cohen Charter on Medical Professionalism: Putting the Charter into Practice Yevgeniya Nusinovich Charter on Medical Professionalism: Putting the Charter into Practice Risa Lavizzo-Mourey Charter on Medical Professionalism: Putting the Charter into Practice Christopher J. Lyons Charter on Medical Professionalism: Putting the Charter into Practice Richard L. Cruess and Sylvia L. Cruess Charter on Medical Professionalism: Putting the Charter into Practice Sadeq A. Quraishi and Ayesha N. Khalid Charter on Medical Professionalism: Putting the Charter into Practice Neil J. Smelser Charter on Medical Professionalism: Putting the Charter into Practice Charles M. Haskell Charter on Medical Professionalism: Putting the Charter into Practice Neil J. Smelser Charter on Medical Professionalism: Putting the Charter into Practice Donatella Lippi , GianFranco Gensini , and Andrea A. Conti Charter on Medical Professionalism: Putting the Charter into Practice Neil J. Smelser Charter on Medical Professionalism: Putting the Charter into Practice Jerome C. Arnett Jr. Charter on Medical Professionalism: Putting the Charter into Practice Sylvia L. Cruess and Richard L. Cruess Charter on Medical Professionalism: Putting the Charter into Practice Robert Feldman Metrics 20 May 2003Volume 138, Issue 10Page: 854KeywordsComplex systemsHealth careHealth care quality ePublished: 20 May 2003 Issue Published: 20 May 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...