THE PHYSIOLOGICAL AND BIOCHEMICAL BASIS FOR THE USE OF VITAMIN E IN CARDIOVASCULAR DISEASE
Authors: W E SHUTE, E V SHUTE, A VOGELSANG
Journal: Annals of Internal Medicine (1949)

Article1 May 1949THE PHYSIOLOGICAL AND BIOCHEMICAL BASIS FOR THE USE OF VITAMIN E IN CARDIOVASCULAR DISEASEW. E. SHUTE, B.A., M.D., E. V. SHUTE, B.A., M.B., F.R.C.S.(C), ARTHUR VOGELSANG, B.A., M.D.W. E. SHUTE, B.A., M.D.Search for more papers by this author, E. V. SHUTE, B.A., M.B., F.R.C.S.(C)Search for more papers by this author, ARTHUR VOGELSANG, B.A., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-30-5-1004 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVitamin E first came to medical notice as a preservative of precarious pregnancies, whether habitual1 or threatened abortions.2, 3 Its rôle in the maintenance of normal gestation was later emphasized with respect to premature placental detachment4 and non-eclamptic toxemias.5 Certain uses in gynecology, such as in the menopause,6, 7 in senile vulvitis8, 9, 10 and even in male sterility,11 were also reported. But, fundamentally, for the first 25 years of its existence it did justify the appellation of "fertility vitamin" which now seems so misleading.That this vitamin played a much more significant role than this "bit part" could have...Bibliography1. VOGT-MOLLER P: Treatment of sterility and habitual abortion with wheat germ and wheat germ oil, Acta Obst. et Gynec. Scandin., 1933, xiii, 219. CrossrefGoogle Scholar2. WATSON EM: Clinical experiences with wheat germ oil, Canad. Med. Assoc. Jr., 1936, xxxiv, 134. Google Scholar3. SHUTE EV: Vitamin E symposium, 1939, London, England. Google Scholar4. Idem.: Observations on the aetiology of abruptio placentae and its response to vitamins in therapy, Jr. Obst. and Gynec. British Emp., xliv, 121. Google Scholar5. Idem.: Non-eclamptic late toxaemias treated by vitamin E, Am. Jr. Surg., 1946, lxxi, 470. Google Scholar6. Idem.: Notes on the menopause, Canad. Med. Assoc. Jr., 1937, xxxvii, 350. Google Scholar7. CHRISTY CJ: Vitamin E in menopause, Am. Jr. Obst. and Gynec., 1945, l, 84. CrossrefGoogle Scholar8. SHUTE EV: Vaginitis and vulvitis associated with an excess of oestrogen in the blood, Jr. Am. Med. Assoc., 1938, cx, 889. CrossrefGoogle Scholar9. Idem.: Degenerative vulvovaginitis associated with oestrogen imbalance, Jr. Obst. and Gynec. British Emp., 1942, xlix, 482. Google Scholar10. HAINSYM AMJC: Control of menopausal flushes by vitamin E, British Med. Jr., 1943, ii, 8. CrossrefGoogle Scholar11. BISKINDFALK MSHC: Nutritional therapy of infertility in male, Jr. Clin. Endocrinology, 1943, iii, 148. CrossrefGoogle Scholar12. VOGELSANGSHUTESHUTE ABEVWE: Some medical uses of vitamin E, Med. Rec., 1948, cxli, 79. Google Scholar13. HICKMANHARRIS KCPL: Advances in enzymology, 1946, N. Y. Interscience Pub., pp. 469 to 524. Google Scholar14. MADSEN LL: Comparative effects of cod liver oil, cod liver oil concentrate, lard and cottonseed oil in synthetic diets on development of nutritional muscular dystrophy, Jr. Nutr., 1936, xi, 471. CrossrefGoogle Scholar15. MASONEMMELS KEAF: Vitamin E and muscle pigment in the rat, Anat. Rec., 1945, xcii, 33. CrossrefGoogle Scholar16. GATZHOUCHIN AJOB: Histological observations on the vitamin E deficient rabbit heart, Anat. Rec., 1946, xcvii, 337. Google Scholar17. BRAGDON W: Proc. Second Vitamin E Conference, Columbia University, N. Y., 1948, Jan. 23. Google Scholar18. BUTTURINI U: The heart in avitaminosis E, Gior. di. Clin. Med., 1946, xxvii, 400. Google Scholar19. MARTINFAUST EVFB: The heart in avitaminosis E, Exper. Med. and Surg., 1947, v, 455. Google Scholar20. ENSOR CR: Electrocardiograms of rats in vitamin E deficiency, Am. Jr. Physiol., 1946, cxlvii, 477. CrossrefGoogle Scholar21. MASONTELFORD KEIR: Some manifestations of vitamin E deficiency in the monkey, Arch. Path., 1947, xliii, 363. Google Scholar22. HOLMAN RL: Prevention of experimental arteritis in dogs by vitamin E, Proc. Soc. Exper. Biol. and Med., 1947, lxvi, 307. CrossrefGoogle Scholar23. GULLICKSONCALVERLY TWCE: Cardiac failure in cattle on vitamin E-free rations as revealed by electrocardiograms, Science, 1946, civ, 389. Google Scholar24. LAMBERT NH: Cardiac disease in dogs and cats treated with vitamin E, Vet. Rec., 1947, lix, 355. Google Scholar25. HARRISHICKMANJENSINSPIES PLKJLTD: Survey of blood plasma levels of vitamin A, carotine, ascorbic acid and tocopherols of persons in an area of endemic malnutrition, Am. Jr. Pub. Health, 1946, xxxvi, 155. CrossrefGoogle Scholar26. QUAIFEHARRIS MLPL: Vitamin E, Ann. Rev. Biochem., 1947, xvi, 348. Google Scholar27. HICKMAN K: Letter, Lancet, 1948, i, 652. CrossrefGoogle Scholar28. GOVIERGANZGRELIS WMNME: Effect of alpha tocopherol phosphate, digitoxin and certain compounds related to the latter on cardiac muscle metabolism in vitro, Jr. Pharmacol., 1946, lxxxviii, 373. Google Scholar29. SPAULDINGGRAHAM MEWD: Enzymatic degradation of cozymase and inhibitory action of alpha tocopherol phosphate, Jr. Biol. Chem., 1947, clxx, 711. CrossrefGoogle Scholar30. VOGELSANGSHUTESHUTE AEVWE: Vitamin E in heart disease, Med. Rec., 1948, clx, 279. Google Scholar31. SHUTE WE: Three cases of acute nephritis treated with vitamin E, Urol. and Cut. Rev., 1946, li, 679. Google Scholar32. VOGELSANGSHUTESHUTE AEVWE: Some medical uses of vitamin E, Med. Rec., 1948, clxi, 155. Google Scholar33. SHUTESHUTEVOGELSANG WEEVA: Alpha tocopherol in heart disease, a review after one year of cases previously published, Brit. Med. Jr. (in press). Google Scholar34. VOGELSANG AB: Human electrocardiographic changes during vitamin E therapy, Proc. Third Vitamin E Conference, Montreal General Hospital, May 15, 1948. Google Scholar35. SHUTE WE: The influence of vitamin E on the human electrocardiogram, ibid. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: London,*Received for publication August 7, 1948. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe effect of vitamin E deficiency on some platelet membrane properties.Die Pathologie der Avitaminosen und HypervitaminosenVitamin Supplementation in Health and Disease 1 May 1949Volume 30, Issue 5Page: 1004-1008KeywordsCardiovascular diseasesPregnancyPreservativesVitamin E ePublished: 1 December 2008 Issue Published: 1 May 1949 PDF downloadLoading ...