PRIMARY SYSTEMIC AMYLOIDOSIS WITH CARDIAC INVOLVEMENT AND WITH RUSSELL BODIES IN BONE MARROW
Authors: Byron A. Nichol, S. M. Dozier, Thomas W. Mattingly
Journal: Annals of Internal Medicine (1957)

Case Reports1 January 1957PRIMARY SYSTEMIC AMYLOIDOSIS WITH CARDIAC INVOLVEMENT AND WITH RUSSELL BODIES IN BONE MARROWBYRON A. NICHOL, S. M. DOZIER, THOMAS W. MATTINGLYBYRON A. NICHOLSearch for more papers by this author, S. M. DOZIERSearch for more papers by this author, THOMAS W. MATTINGLYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-46-1-156 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis case report concerns a patient who presented a diagnostic problem of cardiomegaly and myocardial failure of unknown etiology and in whom the outstanding pathologic finding at autopsy was primary systemic amyloidosis with marked cardiac involvement. An additional finding of great interest was the presence of numerous Russell bodies in the bone marrow. For previously reported cases (approximately 100) and reviews of the literature of primary systemic amyloidosis,1-14we found no report of similar bone marrow findings though Snapper, Turner and Moscovitz15have reported Russell bodies in the bone marrow in atypical amyloidosis accompanying multiple myeloma. Morphologically, amyloidosis associated with...Bibliography1. ReimannKouckyEklund HARFCM: Primary amyloidosis limited to tissue of mesodermal origin, Am. J. Path. 11: 977, 1935. MedlineGoogle Scholar2. KoletskyStecher SRM: Primary systemic amyloidosis—involvement of cardiac valves, joints, and bones, with pathologic fracture of the femur, Arch. Path. 27: 267, 1939. Google Scholar3. Lindsay S: The heart in primary systemic amyloidosis, Am. Heart J. 32: 419, 1946. CrossrefMedlineGoogle Scholar4. Eisen HN: Primary systemic amyloidosis, Am. J. Med. 1: 144, 1946. CrossrefMedlineGoogle Scholar5. HigginsHiggins WHWH: Primary amyloidosis; a clinical and pathological study, Am. J. M. 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Mattingly, MC, Chief, Cardiology Service, Walter Reed Army Hospital, Washington 12, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHemopoietic System 1 January 1957Volume 46, Issue 1Page: 156-168KeywordsAmyloidosisBone marrowDiagnostic medicineEtiologyHeart failureHospital medicineMultiple myelomaMyelomaPathogenesisResearch laboratories Issue Published: 1 January 1957 PDF downloadLoading ...