CORTISONE THERAPY OF EARLY EPIDEMIC HEMORRHAGIC FEVER: A PRELIMINARY REPORT
Authors: W. J. Sayer, G. Entwhisle, B. Uyeno, R. C. Bignall
Journal: Annals of Internal Medicine (1955)

Article1 April 1955CORTISONE THERAPY OF EARLY EPIDEMIC HEMORRHAGIC FEVER: A PRELIMINARY REPORTW. J. SAYER, G. ENTWHISLE, B. UYENO, R. C. BIGNALLW. J. SAYER, G. ENTWHISLE, B. UYENO, R. C. BIGNALLAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-4-839 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONEpidemic hemorrhagic fever (EHF) is an infectious disease of unknown etiology which was first encountered by the U. S. Army in Korea during the spring of 1951. It is characterized by an initial toxic-febrile state with spontaneous petechiae, leukocytosis and thrombocytopenia, followed by variable degrees of renal and cardiovascular involvement. As yet, no specific therapeutic agent has been found for this disease.A nonspecific beneficial effect from the administration of cortisone in conjunction with the appropriate antibiotic preparation, has been demonstrated in patients ill with typhoid fever,1scrub typhus2and Rocky Mountain spotted fever.3For these patients the toxic-febrile...Bibliography1. SmadelLeyDiercks JEHLFH: Treatment of typhoid fever. I. Combined therapy with cortisone and chloramphenicol, Ann. Int. Med. 34: 1, 1951. LinkGoogle Scholar2. WissemanPatersonSmadelDiercksLey CLPYJEFHHL: Studies on cortisone and antibiotics for prompt therapeutic control of typhoid fever and scrub typhus, J. Clin. Investigation, in press. Google Scholar3. WorkmanHightowerBorgesFurmanParker JBJAFJJERT: Cortisone as an adjunct to chloramphenicol in the treatment of Rocky Mountain spotted fever, New England J. Med. 246: 962, 1952. CrossrefMedlineGoogle Scholar4. MeyersMillerLinmanBethell MCSJWFH: The use of ACTH and cortisone in idiopathic thrombocytopenia and idiopathic acquired hemolytic anemia, Ann. Int. Med. 37: 352, 1952. LinkGoogle Scholar5. RobsonDuthie HNJJ: Capillary and adrenocortical activity, Brit. M. J. 2: 971, 1950. CrossrefMedlineGoogle Scholar6. KatzLeedhamKessler SCLWH: Medical management of hemorrhagic fever, J. A. M. A. 150: 1363, 1952. CrossrefMedlineGoogle Scholar7. Woodward TE: Preliminary report of observations on the use of cortisone in early treatment of hemorrhagic fever, Report to Field Unit, Commission on Hemorrhagic Fever, Armed Forces Epidemiological Board, October, 1953. Google Scholar8. GreismanMoe SGK: A vasodilator substance in the plasma of hemorrhagic fever patients, Report to Commission on Hemorrhagic Fever, Armed Forces Epidemiological Board, Washington, D. C., 6 January 1954. Google Scholar9. Greisman S: Personal communication. Google Scholar10. Anonymous: Technical Bulletin Med. 240, U. S. Army, Hemorrhagic fever, 5 May 1953. Google Scholar11. BarberoKatzKrausLeedham GJSHCL: Clinical and laboratory study of thirty-one patients with hemorrhagic fever, Arch. Int. Med. 91: 177, 1953. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication September 17, 1954. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byExpert Consensus on the Prevention and Treatment of Hemorrhagic Fever with Renal SyndromeGlobal Comprehensive Outlook of Hantavirus Contagion on Humans: A ReviewVaccines and Therapeutics Against HantavirusesProgress on the Prevention and Treatment of Hantavirus DiseaseBunyaviridae : Orthobunyaviruses, Phleboviruses, Nairoviruses, and HantavirusesHantavirus Pulmonary Syndrome in the AmericasHigh-Dose Intravenous Methylprednisolone for Hantavirus Cardiopulmonary Syndrome in Chile: A Double-Blind, Randomized Controlled Clinical TrialHantavirus InfectionsViral hemorrhagic fevers including hantavirus pulmonary syndrome in the AmericasOther Viruses and Emerging Viruses of ConcernReversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathwayRespiratory Hantaan VirusHereditäre und endemische Nephropathien vorwiegend interstitieller LokalisationBolivian hemorrhagic feverArbor-Viren (durch Arthropoden übertragbare Viren)Das epidemische h�morrhagische Fieber 1 April 1955Volume 42, Issue 4Page: 839-851KeywordsAntibioticsArmed forcesEtiologyHemorrhagic feversHyperthermiaInfectious diseasesLeukocytosisObservational studiesTyphoid ePublished: 1 December 2008 Issue Published: 1 April 1955 PDF downloadLoading ...