tbuckley/cabot-search huggingface dataset:
Involvement of the oral cavity in psoriasis: results of a clinical study
Authors: G. Ganzetti, A. Campanati, A. Santarelli, V. Pozzi, E. Molinelli, I. Minnetti, V. Brisigotti, M. Procaccini, M. Emanuelli, A. Offidani
Journal: British Journal of Dermatology (2014)

Journal Article Involvement of the oral cavity in psoriasis: results of a clinical study Get access G. Ganzetti, G. Ganzetti Clinic of Dermatology Polytechnic University of Marche Ancona Italy Search for other works by this author on: Oxford Academic Google Scholar A. Campanati, A. Campanati Clinic of Dermatology Polytechnic University of Marche Ancona Italy Search for other works by this author on: Oxford Academic Google Scholar A. Santarelli, A. Santarelli Department of Clinical Specialistic and Stomatological Sciences Polytechnic University of Marche Ancona Italy Search for other works by this author on: Oxford Academic Google Scholar V. Pozzi, V. Pozzi Department of Clinical Specialistic and Stomatological Sciences Polytechnic University of Marche Ancona Italy Search for other works by this author on: Oxford Academic Google Scholar E. Molinelli, E. Molinelli Clinic of Dermatology Polytechnic University of Marche Ancona Italy Search for other works by this author on: Oxford Academic Google Scholar I. Minnetti, I. Minnetti Clinic of Dermatology Polytechnic University of Marche Ancona Italy Search for other works by this author on: Oxford Academic Google Scholar V. Brisigotti, V. Brisigotti Clinic of Dermatology Polytechnic University of Marche Ancona Italy Search for other works by this author on: Oxford Academic Google Scholar M. Procaccini, M. Procaccini Department of Clinical Specialistic and Stomatological Sciences Polytechnic University of Marche Ancona Italy Search for other works by this author on: Oxford Academic Google Scholar M. Emanuelli, M. Emanuelli Department of Clinical Specialistic and Stomatological Sciences Polytechnic University of Marche Ancona Italy Search for other works by this author on: Oxford Academic Google Scholar A. Offidani A. Offidani Clinic of Dermatology Polytechnic University of Marche Ancona Italy Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 1, 1 January 2015, Pages 282–285, https://doi.org/10.1111/bjd.13201 Published: 01 January 2015
Partial seizures presenting as panic attacks
Authors: S. A Thompson
Journal: BMJ (2000)

The evidence base to support the development of ACP processes for people with intellectual disabilities and their families is limited. There is a paucity of studies that have explored the most appropriate means of engaging this population in ACP discussions. Evidence from previous research would suggest that people with intellectual disabilities are at risk of both ‘under-treatment’ at the end of life, for example, through sub-optimum pain management, and ‘over-treatment’, for example overly-interventionist care. As a result the extent to which people with intellectual disabilities and their families want to engage in ACP, and the mechanisms by which this can be achieved, remains unclear, particularly within the New Zealand (NZ) context. IDEA services has over 800 community homes supporting around 5800 people with intellectual disabilities across NZ, of whom 24% are aged over 50 years resulting in an increase in the incidence and prevalence of conditions such as dementia. In this presentation, we report the preliminary findings from a qualitative interview study conducted with individuals including care staff from IDEA services, general practitioners and family care givers regarding their views about ACP focusing on the barriers to, and facilitators of ACP. We report on the views of participants in relation to: understandings of ACP, the importance of interpersonal relations and the role of advocacy. This study suggests the need to rethink the traditional autonomy focused framework of ACP and the need for broader initiatives that incorporate the views of significant others to achieve an individuals9 end of life care wishes.
Splenic Lymphangioma An Unusual Manifestation of The Klippel-Trenaunay-Weber Syndrome
Authors: CHRIS A. NUSSER, DAVID W. TUGGLE, KIMBERLY B. MCLANAHAN, JOE C. LEONARD
Journal: Clinical Nuclear Medicine (1995)

Klippel-Trenaunay syndrome is a congenital vascular anomaly consisting of the clinical triad of port-wine nevus (cutaneous capillary hemangloma), with varicose veins on the lateral aspect and osseous and soft tissue hypertrophy of the affected extremity. Klippel-Trenaunay-Weber syndrome or Parkes-Weber syndrome refers to the same triad plus arteriovenous fistulas/ectasia in the affected extremity. Involvement is most commonly unilateral (85%) and in a lower extremity (95%). Associated findings include hemanglomas of the liver, spleen, colon, bladder, and spine, as well as lymphanglomas of limbs and trunk.
Virilizing Adrenal Adenoma with Studies on the Steroid Content of the Adrenal Venous Effluent and a Review of the Literature*
Authors: J. L. GABRILOVE, A. T. SEMAN, R. SABET, H. A. MITTY, G. L. NICOLIS
Journal: Endocrine Reviews (1981)

THIS IS a report of a new instance of a patient with a virilizing adrenal adenoma in whom the steroid content of both adrenal venous effluents was assayed. In addition the study delineates the clinical and biochemical findings in the reported instances of virilizing adenoma including the available data on the steroid content of adrenal venous effluent. Pure virilizing adrenal adenoma in the adult female is a rare disorder. We have been able to collect only 34 such instances in the literature, including 3 of our own (1–30) (Table 1). For purposes of comparison, the details of the clinical features and biochemical values obtained in 18 reported children with virilizing adrenal adenoma (12, 31–45) (Table 2) are also presented, as well as some data on the adrenal venous effluent on all 8 adult female patients with pure virilizing adrenocortical carcinoma documented in the literature (9, 12, 46–49) (Table 3).
Mannan-Binding Lectin (MBL) Serum Levels in a Healthy Adult Population: Gender Differences in Prevalence of MBL Deficiency
Authors: R.J.M. Engler, M.M. Klote, C.E. Spooner, G.T. Reardon, J.F. Halsey, M.R. Nelson
Journal: Journal of Allergy and Clinical Immunology (2010)
Hematopoietic Stem Cell Gene Therapy for the Multisystemic Lysosomal Storage Disorder Cystinosis
Authors: Frank Harrison, Brian A Yeagy, Celine J Rocca, Donald B Kohn, Daniel R Salomon, Stephanie Cherqui
Journal: Molecular Therapy (2012)

Cystinosis is an autosomal recessive metabolic disease that belongs to the family of lysosomal storage disorders (LSDs). The defective gene is CTNS encoding the lysosomal cystine transporter, cystinosin. Cystine accumulates in all tissues and leads to organ damage including end-stage renal disease. Using the Ctns(-/-) murine model for cystinosis, we tested the use of hematopoietic stem and progenitor cells (HSPC) genetically modified to express a functional CTNS transgene using a self-inactivating-lentiviral vector (SIN-LV). We showed that transduced cells were capable of decreasing cystine content in all tissues and improved kidney function. Transduced HSPC retained their differentiative capabilities, populating all tissue compartments examined and allowing long-term expression of the transgene. Direct correlation between the levels of lentiviral DNA present in the peripheral blood and the levels present in tissues were demonstrated, which could be useful to follow future patients. Using a new model of cystinosis, the DsRed Ctns(-/-) mice, and a LV driving the expression of the fusion protein cystinosin-enhanced green fluorescent protein (eGFP), we showed that cystinosin was transferred from CTNS-expressing cells to Ctns-deficient adjacent cells in vitro and in vivo. This transfer led to cystine decreases in Ctns-deficient cells in vitro. These data suggest that the mechanism of cross-correction is possible in cystinosis.
Current Status of Minimally Invasive Treatment Options for Localized Prostate Carcinoma
Authors: H.P. Beerlage, S. Th&uuml;roff, St. Madersbacher, A.R. Zlotta, G. Aus, Th.M. de Reijke, J.J.M.C.H. de la Rosette
Journal: European Urology (2000)
To Butterfly or To Needle: The Specimen Testing Question
Authors: William M. Miller
Journal: Annals of Internal Medicine (2004)

Letters2 November 2004To Butterfly or To Needle: The Specimen Testing QuestionWilliam M. Miller, MDWilliam M. Miller, MDFrom Quest Diagnostics, Tucker, GA 30084.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-9-200411020-00033-w1 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The letter by Hefler and colleagues (1) on the butterfly collection device for venipuncture was quite interesting, and the results were not surprising. I would like to know, however, the outcome of the testing of each specimen. Were there more problem specimens (hemolysis, insufficient quantity) in the butterfly cohort than in the conventional needle group? The goal of good venipuncture technique is not only patient comfort but also the collection of optimal blood specimens. If use of the butterfly device results in more problem specimens, then the reduction in discomfort is a false gain.Reference1. Hefler L, Grimm C, Leodolter S, Tempfer C. To butterfly or to needle: the pilot phase [Letter]. Ann Intern Med. 2004;140:935-6. [PMID: 15172916] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Quest Diagnostics, Tucker, GA 30084. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoTo Butterfly or To Needle: The Pilot Phase Lukas Hefler , Christoph Grimm , Sepp Leodolter , and Clemens Tempfer To Butterfly or To Needle: The Specimen Testing Question Lukas Hefler Metrics 2 November 2004Volume 141, Issue 9Page: W-140KeywordsBloodPhlebotomy ePublished: 2 November 2004 Issue Published: 2 November 2004 Copyright & PermissionsCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Protection from reoxygenation injury by inhibition of rac1.
Authors: K S Kim, K Takeda, R Sethi, J B Pracyk, K Tanaka, Y F Zhou, Z X Yu, V J Ferrans, J T Bruder, I Kovesdi, K Irani, P Goldschmidt-Clermont, T Finkel
Journal: Journal of Clinical Investigation (1998)

We demonstrate that adenoviral-mediated gene transfer of a dominant negative rac1 gene product (N17rac1) inhibits the intracellular burst of reactive oxygen species (ROS) that occurs after reoxygenation of vascular smooth muscle cells. In contrast, expression of a dominant negative ras gene (N17ras) had no effect. Challenge of control cells and cells expressing N17rac1 with a direct oxidant stress produced an equivalent increase in intracellular ROS levels and subsequent cell death. This suggests that N17rac1 expression appears to block production of harmful oxygen radicals and does not act directly or indirectly to scavenge ROS generated during reoxygenation. Expression of N17rac1 results in protection from hypoxia/reoxygenation-induced cell death in a variety of cell types including vascular smooth muscle cells, fibroblasts, endothelial cells, and ventricular myocytes. These results suggest that reoxygenation injury requires the activation of rac proteins, and that inhibition of rac-dependent pathways may be a useful strategy for the prevention of reperfusion injury in ischemic tissues.
Pontine Glioma
Authors: Gerald Rosen
Journal: JAMA (1974)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ortho-cresotinate and Diabetes Mellitus
Authors: T. D. Lightbody, J. Reid
Journal: BMJ (1960)

Aspirin in full therapeutic doses relieves mild diabetic symptoms, lowers the fasting blood-sugar level, and reduces glycosuria and ketonuria in patients with mild to moderately severe diabetes mellitus (Reid, Macdougall, and Andrews, 1957).One of the disadvantages of aspirin therapy, however, is the fairly frequent occurrence of undesirable side-effects, such as tinnitus and deafness, with the high dosage of the drug required to achieve satisfactory control of the diabetes.HO 0 ci 10 Q1H_ -CH3 Ortho-cresotinic acid.
Intracellular Calcium Dynamics and Anisotropic Reentry in Isolated Canine Pulmonary Veins and Left Atrium
Authors: Chung-Chuan Chou, Motoki Nihei, Shengmei Zhou, Alex Tan, Ayaka Kawase, Edgar S. Macias, Michael C. Fishbein, Shien-Fong Lin, Peng-Sheng Chen
Journal: Circulation (2005)

Rapid activations due to either focal discharge or reentry are often present during atrial fibrillation (AF) in the pulmonary veins (PVs). The mechanisms of these rapid activations are unclear.We studied 7 isolated, Langendorff-perfused canine left atrial (LA) and PV preparations and used 2 cameras to map membrane potential alone (Vm, n=3) or Vm and intracellular calcium simultaneously (Ca(i), n=4). Rapid atrial pacing induced 26 episodes of focal discharge from the proximal PVs in 5 dogs. The cycle lengths were 223+/-52 ms during ryanodine infusion (n=13) and 133+/-59 ms during ryanodine plus isoproterenol infusion (n=13). The rise of Ca(i) preceded Vm activation at the sites of focal discharge in 6 episodes of 2 preparations, compatible with voltage-independent spontaneous Ca(i) release. Phase singularities during pacing-induced reentry clustered specifically at the PV-LA junction. Periodic acid-Schiff (PAS) stain identified large cells with pale cytoplasm along the endocardium of PV muscle sleeves. There were abrupt changes in myocardial fiber orientation and increased interstitial fibrosis in the PV and at the PV-LA junction.PV muscle sleeves may develop voltage-independent Ca(i) release, resulting in focal discharge. Focal discharge may also be facilitated by the presence of PAS-positive cells that are compatible with node-like cells. During reentry, phase singularities clustered preferentially at sites of increased anisotropy such as the PV-LA junction. These findings suggest that focal discharge caused by spontaneous calcium release and anisotropic reentry both contribute to rapid activations in the PVs during AF.
Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B
Authors: Michael Oldridge, Ana M Fortuna, Monika Maringa, Peter Propping, Sahar Mansour, Christine Pollitt, Thomas M. DeChiara, Robert B. Kimble, David M. Valenzuela, George D. Yancopoulos, Andrew O.M. Wilkie
Journal: Nature Genetics (2000)
Hemodynamic Aspects of Hemorrhagic and Septic Shock
Authors: Robert W. Hopkins
Journal: JAMA (1965)

The hemodynamic changes associated with hemorrhagic  have been well documented in animals and man. A relative paucity of information is available, however, concerning the alterations of hemodynamics occurring during septic shock in man. The administration of endotoxin to animals has demonstrated a fall in arterial pressure, a decrease in the circulating blood volume, and a reduction in the cardiac output. Although the assumption has commonly been made that similar changes occur in man, few data are available to confirm this. Udhoji et al 1 have studied five patients with clinical  associated with infection. They report a reduction in the cardiac index in these patients, although in one of their patients the cardiac output was in the high normal range. In two of their patients, the blood volume was normal or above normal. Ebert and Stead 2 have demonstrated a normal blood volume in certain types of  associated
Collective Bargaining by Physicians — Labor Law, Antitrust Law, and Organized Medicine
Authors: Sujit Choudhry, Troyen A. Brennan
Journal: New England Journal of Medicine (2001)

Collective bargaining has caught the imagination of physicians across the United States. Although physicians' unions have existed since the 1970s, union members have always constituted an extremely small percentage of practicing physicians.1 However, physicians are turning to unions to increase their bargaining power with managed-care organizations. They are also viewing unions as a way to help reclaim their clinical autonomy and to preserve and enhance the quality of care.2 Leading medical organizations are now supporting these efforts to reclaim clinical autonomy and increase reimbursement through collective bargaining. The American Medical Association (AMA), which opposed the idea of physicians' unions for . . .
A kinetic study of the pH optimum of canine cardiac cathepsin D
Authors: E. A OGUNRO, A. G FERGUSON, M. LESCH
Journal: Cardiovascular Research (1980)

Journal Article A kinetic study of the pH optimum of canine cardiac cathepsin D Get access EDWARD A OGUNRO, EDWARD A OGUNRO * From the Department of Medicine, Section of Cardiology, Northwestern University Medical School, Chicago, Illinois *Reprint requests to: Edward A Ogunro, PhD, Department of Medicine, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois 60611, USA. Search for other works by this author on: Oxford Academic PubMed Google Scholar ALAN G FERGUSON, ALAN G FERGUSON From the Department of Medicine, Section of Cardiology, Northwestern University Medical School, Chicago, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar MICHAEL LESCH MICHAEL LESCH From the Department of Medicine, Section of Cardiology, Northwestern University Medical School, Chicago, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 14, Issue 5, May 1980, Pages 254–260, https://doi.org/10.1093/cvr/14.5.254 Published: 01 May 1980
Is Evidence-Based Medicine Relevant to the Developing World?
Authors: Paul Chinnock, Nandi Siegfried, Mike Clarke
Journal: PLoS Medicine (2005)

Although there is still some resistance to  evidence-based medicine movement evidence-based health care has now become widely accepted and adopted. Systematic reviews of  effectiveness of health care interventions are  engine room of evidence-based health care; much has been written about how these reviews should be conducted and what they can achieve. If  case for  use of systematic reviews is good in developed countries--and we think it is--then  case is even stronger in  developing world. Wherever health care is provided and used it is essential to know which interventions work which do not work and which are likely to be harmful. This is especially important in situations where health problems are severe and  scarcity of resources makes it vital that they are not wasted. But are  systematic reviews that have so far been published relevant and of practical use to those who provide health care in the majority world (i.e. in developing countries). In our view  relevance of systematic reviews to frontline health care workers in developing countries has so far been limited for a number of reasons.   (excerpt)
PROTEIN AS AN ADJUNCT IN THE TREATMENT OF RESISTANT SYPHILIS
Authors: RUSSELL D. HERROLD
Journal: JAMA (1926)

There are patients with syphilis who show only a slight reduction in the Wassermann reaction under the usual drug therapy. As the Wassermann test is considered the most important criterion of the benefit of treatment in latent and inactive syphilis, this type of patient is classified as resistant or Wassermann-fast. The serologic reaction, however, must not be taken as the only test of cure. An analysis was made during the World War of a series of patients who had been given the routine treatment of neo-arsphenamin intravenously and mercurial oil intramuscularly. The patients were adult males in the same age period, with similar conditions of life, and would seem to be a particularly good control group, since they received regular and routine series of injections. As indicated in Table 1, the best results were had in the class diagnosed early by a positive dark field while the Wassermann test was
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Authors: G S Hotamisligil, P Arner, J F Caro, R L Atkinson, B M Spiegelman
Journal: Journal of Clinical Investigation (1995)

Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis. Recent studies in animal models have indicated that TNF-alpha plays an important role in mediating the insulin resistance of obesity through its overexpression in fat tissue. However, the mechanisms linking obesity to insulin resistance and diabetes in humans remain largely unknown. In this study we examined the expression pattern of TNF-alpha mRNA in adipose tissues from 18 control and 19 obese premenopausal women by Northern blot analysis. TNF-alpha protein concentrations in plasma and in conditioned medium of explanted adipose tissue were measured by ELISA. Furthermore, the effects of weight reduction by dietary treatment of obesity on the adipose expression of TNF-alpha mRNA were also analyzed in nine premenopausal obese women, before and after a controlled weight-reduction program. These studies demonstrated that obese individuals express 2.5-fold more TNF-alpha mRNA in fat tissue relative to the lean controls (P < 0.001). Similar increases were also observed in adipose production of TNF-alpha protein but circulating TNF-alpha levels were extremely low or undetectable. A strong positive correlation was observed between TNF-alpha mRNA expression levels in fat tissue and the level of hyperinsulinemia (P < 0.001), an indirect measure of insulin resistance. Finally, body weight reduction in obese subjects which resulted in improved insulin sensitivity was also associated with a decrease in TNF-alpha mRNA expression (45%, P < 0.001) in fat tissue. These results suggest a role for the abnormal regulation of this cytokine in the pathogenesis of obesity-related insulin resistance.
Caution in interpretation needed
Authors: S. Senn, R. Bakshi, N. Ezzet
Journal: BMJ (1995)

EDITOR,—Considerable caution must be exercised in interpreting the results of Lyn March and colleagues' n of 1 trials in osteoarthritis.1 For example, the authors observe that “seven of he eight patients who changed treatment from baseline changed to paracetamol (P=0.07, exact binomial).” Of the 20 patients analysed, 16 were taking a non-steroidal anti-inflammatory drug and only three were taking paracetamol. Therefore, at most three patients could have changed their treatment from paracetamol.

Furthermore, the authors implicitly assume that failure to find …