PLASMA CREATININE DETERMINATION AS A TEST OF LOW GRADE KIDNEY DAMAGE
Authors: Aaron Arkin, Hans Popper, Fred A. Goldberg
Journal: Annals of Internal Medicine (1941)

Article1 October 1941PLASMA CREATININE DETERMINATION AS A TEST OF LOW GRADE KIDNEY DAMAGEAARON ARKIN, PH.D., M.D., F.A.C.P., HANS POPPER, M.S., M.D., FRED A. GOLDBERG, M.D.AARON ARKIN, PH.D., M.D., F.A.C.P.Search for more papers by this author, HANS POPPER, M.S., M.D.Search for more papers by this author, FRED A. GOLDBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-15-4-700 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWhereas there are well established methods of determining definite kidney insufficiency, the detection of low grade kidney damage by simple methods is still a problem. The purpose of this study is to show the value of plasma creatinine determination by newer methods, in the solution of this question.In kidney damage the glomerular function is usually the first to be impaired as indicated by reduction of glomerular filtration. The original method of Rehberg1who used the exogenous creatinine clearance as a measure of glomerular filtration has been discarded, since in man creatinine is secreted when the blood level is artificially...References1. REHBERG PB: Studies on kidney function, Biochem. Jr., 1926, xx, 445-460. Google Scholar2. SMITH HW (a) : The physiology of the kidney, 1937, Oxford Press, New York. (b) SHANNON, J. A.: The renal excretion of creatinine in man, Jr. Clin. Invest., 1935, xiv, 403-410. (c) MILLER, B. F., and WINKLER, A. W.: The renal excretion of endogenous creatinine in man, comparison with exogenous creatinine and inulin, Jr. Clin. Invest., 1938, xvii, 31-40. Google Scholar3. 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Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication April 25, 1941.From the Cook County Hospital (Medical Service of Dr. Aaron Arkin) and the Cook County Graduate School of Medicine, Chicago, Illinois.†Research Fellow, Cook County Graduate School of Medicine. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byUntersuchungen über den Kreatinstoffwechsel 1 October 1941Volume 15, Issue 4Page: 700-707KeywordsBloodBlood plasmaCreatinineGrading of Recommendations Assessment Development and EvaluationGraduate medical educationHospital medicineKidneysMedical servicesRenal failure ePublished: 1 December 2008 Issue Published: 1 October 1941 PDF downloadLoading ...