tbuckley/cabot-search huggingface dataset:
A Clinician's View of Neuromuscular Diseases
Authors: Nicholas A. Vick
Journal: JAMA (1978)

This is a superb book, certainly the best yet written about diseases of nerve and muscle. I find it hard to imagine that someone will soon do better. A clinician's book, it is in harmony and balance with the clinical realities of nerve and muscle disease. What is rare is treated with brevity, while common problems such as Duchenne's dystrophy and polymyositis are covered completely. It is a book in the tradition of British rather than American neurology, being free of excess baggage, multiple authors, repetition, and trivia. Brooke's language is literate and stylish, while at the same time direct, utterly clear, and beautifully suited to the expression of his personal views. These have been acquired over many years of caring for people with nerve and muscle disease. His many illustrations are excellent. I am sure there has never been so complete a collection in one convenient place. Most illustrations
Remarks on THE MEDICAL ASPECTS OF HAEMATURIA
Authors: T. Horder
Journal: BMJ (1927)

TAxE title of this discussion is rather a misnomer, for it suggests that cases presenting this very common and important symptom can be divided into two classes: medical nand surgical.I suggest that the condition of haematuria demonstrates-what I take it we all believe- that, in the first instance at all events, all patients are both potentially medical and surgical: that is to say, they are suffering from pathological conditions, and we do not know at first-sometimes we do not know at last-whether these
Ageism in services for transient ischaemic attack and stroke: Ageism or cost-benefit analysis?
Authors: Michael A McDowall
Journal: BMJ (2006)

EDITOR—Young comments that ageism will always prosper when resources are inadequate for the target population.1 Is this really ageism, or is it application of a cost-benefit analysis—spending the limited resources where the greatest benefits will accrue?

I suspect that most “ageism” in the system is based on the belief that the greatest benefit over …
The Counterrevolution in Health Care Financing
Authors: Victor R. Fuchs
Journal: New England Journal of Medicine (1987)

The revolution in heath care financing is transforming American medicine. Medicare's prospective payment system based on diagnosis-related groups, the spread of health maintenance and preferred-provider organizations, the increased use of deductibles and co-payments, and a wide variety of statewide cost-containment programs have dramatically altered the incentives and constraints facing physicians and other health care providers.The roots of the revolution, which had been growing for years, included overuse of services resulting from open-ended third-party reimbursement, inadequate evaluation of new technologies, inefficient and inequitable cross-subsidization, and excess supplies of hospital beds and specialists. Radical changes in health care financing and organization . . .
Liquorice compound beats latent herpesvirus
Authors: Jane Bradbury
Journal: The Lancet Infectious Diseases (2005)

Researchers at the New York University School of Medicine (NY, USA) may have found a way to treat latent Kaposi's sarcoma-associated herpesvirus (KSHV, also known as HHV8) infections. Ornella Flore and colleagues report that glycyrrhizic acid (GA)—a compound isolated from liquorice that inhibits the lytic replication of other herpesviruses—terminates KSHV latent infection of B lymphocytes (J Clin Invest 2005; 115: 642–52). "This is the first time we have found anything that targets latent gene expression in herpesvirus-infected cells", says Flore, "but it is too soon to say whether GA will be effective against other latent herpesviruses or suitable for clinical use against KSHV".
Relationship Between Plasma Insulin and Blood Pressure in South African Black Women in Johannesburg
Authors: Barry I Joffe, Vanessa R Panz, Jefrey R Wing, Frederick J Raal, Harold C Seftel
Journal: Diabetes Care (1992)

Objectives To examine the relationship between fasting plasma insulin and blood pressure (BP) in 40 urbanized normotensive South African black women aged 24–60 yr, and to assess the effects of body mass index (BMI) and fasting plasma glucose on BP. Research Design and Methods The women comprised equal numbers of young nonobese nondiabetic subjects, middle-aged nonobese nondiabetic subjects, middle-aged obese nondiabetic subjects, and middle-aged obese newly diagnosed non-insulin-dependent diabetic subjects. Systolic and diastolic BPs were recorded (in duplicate) after 15 min of recumbency, and fasting plasma glucose and insulin levels were determined thereafter. The data were analyzed by simple and multivariate regression. Results There was a wide distribution of individual physical and biochemical features. With simple correlations, systolic BP correlated significantly with age, BMI, and fasting glucose but not with insulin. Diastolic BP correlated significantly with all four variables (r = 0.37, P &amp;lt;0.05). When adjusted for age, BMI, and glucose, however, the significant correlation between diastolic BP and insulin diminished (r = −0.04). Conclusions As in other nonwhite communities, plasma insulin does not appear to play a major role in regulating the BP of South African black women.
The Rate of Disappearance of Lanatoside C. and Digitoxin from the Blood of Rats
Authors: RENÉ BINE, MEYER FRIEDMAN, CATHERINE BLAND
Journal: Circulation (1950)

By means of the embryonic duck heart preparation, both lanatoside C. and digitoxin could be detected and quantitatively measured in the sera of rats after parenteral administration of both drugs. A study of the behavior of the two glycosides in blood indicated that a striking difference existed in the respective rates of disappearance of both drugs from the bloodstream.
Arsine toxicity aboard the Asiafreighter.
Authors: S P Wilkinson, P McHugh, S Horsley, H Tubbs, M Lewis, A Thould, M Winterton, V Parsons, R Williams
Journal: BMJ (1975)

Eight sailors on board the Asiafreighter were exposed to arsine that had escaped from a cylinder in the cargo hold. Four suffered severe toxicity and within a few hours had developed fever, weakness, nausea, vomiting, diarrhoea, abdominal pain, and haemoglobinuria. These patients had pronounced intravascular haemolysis, which in one patient was complete. This patient was also stuporose and anoxic, a condition attributed to failure of oxygen transport and sludging of red cell debris in the cerebral and pulmonary circulations, but he regained a normal level of consciousness after exchange transfusion. Evidence of marrow depression was present: the reticulocyte response to the haemolysis was poor and there was a thrombocytopenia. All four patients developed renal failure, one being totally anuric for five weeks. Two patients developed peripheral neuropathy, and one was still severely disabled six months after the incident. The other four patients had a similar, though less severe, illness.
Somatic rearrangement of the TP63 gene preceding development of mycosis fungoides with aggressive clinical course
Authors: R N Chavan, A G Bridges, R A Knudson, R P Ketterling, N Comfere, D A Wada, C Torres-Cabala, D J DiCaudo, G Vasmatzis, M R Pittelkow, A L Feldman
Journal: Blood Cancer Journal (2014)

Cutaneous T-cell lymphomas (CTCLs) comprise a heterogeneous spectrum of T-cell neoplasms with widely varying clinical presentation, biologic behavior and overall outcome. 1,2The most common CTCL is mycosis fungoides (MF), which can range from a localized, indolent process to an aggressive lymphoma with widespread cutaneous and extracutaneous involvement and large-cell transformation (MF-LCT).This biologic and clinical heterogeneity is a feature shared with other T-cell lymphomas, including systemic peripheral T-cell lymphomas (PTCLs).Also common to both CTCLs and PTCLs is a limited understanding of genetic mechanisms of pathogenesis and progression, the elucidation of which could facilitate classification, prognostication and individualized therapy.For example, accurate classification of CTCLs often requires careful clinical and pathological follow-up over time, and an enhanced understanding of CTCL genetics might allow earlier, more definitive classification.Furthermore, genetic biomarkers that identify patients at greatest risk of aggressive clinical behavior could allow initiation of earlier or more intensive treatment protocols that might lead to better outcomes.Finally, knowledge of CTCL genetics could improve biologic understanding of this group of diseases and facilitate the development of more specific, targeted therapies.Although CTCLs and PTCLs are clinically distinct groups of diseases, genetic data have highlighted similarities that suggest biologic interconnectedness.For example, we have shown that chromosomal rearrangements of the DUSP22/IRF4 locus on 6p25.3 are seen in about 30% of both primary cutaneous anaplastic large-cell lymphomas (cALCLs) and systemic ALK-negative ALCLs. 3,4More recently, we identified recurrent rearrangements of TP63 on 3q28 in PTCLs that were associated with poor clinical outcomes. 4,5TP63 encodes p63, a member of the p53 family of transcription factors.Interestingly, although our study was primarily focused on patients with systemic PTCLs, we also identified two patients with unusually aggressive cALCLs that had TP63 rearrangements.Therefore, we undertook the current multi-institutional study to determine the frequency and clinical significance of TP63 rearrangements in an independent series of CTCLs.We reviewed CTCL biopsy specimens from 136 previously unreported patients (mean age, 60 years; age range, 14-96 years; male:female, 1.4:1).Classification followed World Health Organization criteria and is summarized in Table 1.All cases were evaluated for p63 protein expression by immunohistochemistry using the 4A4 clone as previously described, 5 defining positivity as nuclear staining in ⩾ 30% of tumor cells.FISH using dual-fusion and/or breakapart TP63 probes was performed as previously described 5 in all cases that were p63 positive by immunohistochemistry.
Needle in a Haystack
Authors: Krishna R. Polu, Myles Wolf
Journal: New England Journal of Medicine (2006)

A 63-year-old man presented to the emergency department with shortness of breath that had begun the evening before, after he had gone to bed, and worsened progressively during the night. He had had no fevers, chills, cough, hemoptysis, chest pain, or peripheral edema and had no history of congestive heart failure. Five months earlier, a pulmonary embolus had been diagnosed, for which he received warfarin maintenance therapy; the results of prothrombin-time testing, expressed as an international normalized ratio, were consistently above 2.0.
CLINICAL AND SEROLOGIC STUDIES OF NEUROSYPHILIS WITH TRYPARSAMIDE THERAPY
Authors: JULIAN MAST WOLFSOHN
Journal: JAMA (1925)

Neurologists have recognized for years that, in order to treat neurosyphilis effectively, the therapeutic agent must not only have therapeutic activity against the spirochetes but also be able to penetrate easily into the cerebrospinal fluid and nervous parenchyma. Voegtlin<sup>1</sup>has given us valuable data on both these points. He has found that certain arsenicals, such as atoxyl, have relatively high effectiveness, but in therapeutic doses offer certain serious objections, chief of which are the rather frequent serious visual defects following their administration. He found also that certain other arsenicals, such as arsphenamin, neo-arsphenamin and silver arsphenamin, lack the essential penetrative power for the infected tissues, thereby failing to reach the last parasites in sufficient amount to cause their death. Jacobs and Heilbrunner prepared a derivative of atoxyl—tryparsamide, the sodium salt of<i>n</i>-phenylgly-cinamid-<i>p</i>-arsonic acid. This was tested biologically by Brown and Pearce,<sup>2</sup>and later by Voegtlin
Should eye protection be worn during dermatological surgery: prospective observational study
Authors: A.J. Birnie, K.S. Thomas, S. Varma
Journal: British Journal of Dermatology (2007)

There is a potential risk of infection with blood-borne viruses if a doctor receives a blood splash to a mucous membrane. The quantification of facial contamination with blood has never been documented in the context of dermatological surgery.(i) To identify the number of facial blood splashes that occur during skin surgery and to identify the procedures that present higher risks for the operator and assistant. (ii) To assess the provision of eye protection and attitudes to its use in dermatological surgery in the U.K.(i) Prospective, observational study in the skin surgery suite of a U.K. teaching hospital assessing 100 consecutive dermatological surgery procedures, plus 100 consecutive operations in which an assistant was present.number of face-mask visors with at least one blood splash.to identify if any of the following variables influenced the occurrence of a blood splash: grade of operator, site and type of procedure, and the use of electrocautery. (ii) A postal survey of all U.K.-based members of the British Society of Dermatological Surgery (BSDS) was conducted assessing facilities available and the attitudes of U.K.-based clinicians to the use of face masks during surgery.(i) In 33% of all surgical procedures there was at least one facial splash to the operator (range 1-75) and in 15% of procedures the assistant received at least one splash (range 1-11). Use of monopolar electrocautery was significantly less likely to result in splashes to the mask compared with bipolar electrocautery [odds ratio (OR) 0.04; 95% confidence interval (CI) 0.01-0.19]. Compared with the head/neck, operations on the body were significantly more likely to result in splashes to the mask (OR 6.52) (95% CI 1.7-25.07). The type of procedure and the status of the operator did not have a bearing on the likelihood of receiving a splash to the mask. (ii) From the survey, 33 of 159 (20.8%) of BSDS members had no face masks available and 54 of 159 (34.0%) did not wear any facial protection while operating. The majority (53.5%) thought they received a splash in <or= 1% of procedures.There is a substantial risk of a splash of blood coming into contact with the face during dermatological surgery for both the operator and assistant, regardless of the procedure. The risk of receiving a blood splash to the face may be substantially underestimated by U.K.-based dermatologists. The use of protective eyewear is advisable at all times, but particularly when using bipolar electrocautery, or when operating on high-risk individuals.
Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease
Authors: Sanjay Sethi, Timothy F. Murphy
Journal: New England Journal of Medicine (2008)

New molecular, cellular, and immunologic techniques used to study host–pathogen interactions have led to a reexamination of the role of infection in chronic obstructive pulmonary disease (COPD). There is now considerable evidence that infection plays a major role in the pathogenesis and clinical course of COPD. A vicious circle of infection and inflammation is thought to lead to exacerbations of the disease.
Persistence of viral genome into late stages of murine myocarditis detected by polymerase chain reaction.
Authors: L Wee, P Liu, L Penn, J W Butany, P R McLaughlin, M J Sole, C C Liew
Journal: Circulation (1992)

BACKGROUND Enteroviruses have been considered as the most common etiologic agents in clinical myocarditis and dilated cardiomyopathy; however, their pathogenetic role remains unknown. Hence, the relation of viral replication and development of cardiomyopathy has been determined in a murine model of myocarditis by evaluating the persistence of viral genome during acute and chronic stages of myocarditis by means of Northern blot hybridization and polymerase chain reaction (PCR). METHODS AND RESULTS DBA/2 mice (n = 146) were injected peritoneally with 10 plaque-forming units of encephalomyocarditis (EMC) virus, and the control mice (n = 33) were injected with normal saline. Animals were randomly killed at 4, 7, 10, 14, 21, 28, 35, and 42 days after infection. Histology revealed acute myocardial necrosis with massive inflammatory cell infiltrate peaking on day 14 followed by increasing fibrosis and declining chronic inflammation features compatible with dilated cardiomyopathy between days 21 and 42. Northern blot analysis of control and infected hearts showed detectable viral RNA in the infected hearts initially at day 4, peaking by day 7, diminishing between day 7 and day 14, and absent at day 21 and day 28. However, potential viral remnants present in low quantities and undetectable by Northern blot were further detected by PCR followed by confirmation with an internal oligonucleotide probe after day 14 up to day 42. CONCLUSIONS Viral RNA signals on Northern blot showed a strong correlation with massive myocyte necrosis on day 14, but the viral RNA fragment was consistently detectable into late stages of cardiomyopathy on days 21, 28, 35, and 42 by PCR. This indicated that the mature virions are fully developed early in infection and are capable of persisting in the myocardium after virus-mediated myocytolysis stage. Therefore, PCR is an extremely sensitive method for detecting residual viral genome and viral persistence in the myocardium and may offer insights into the pathogenesis of chronic myocarditis leading to dilated cardiomyopathy.
Granulosa cell-derived insulin-like growth factor (IGF) binding proteins are inhibitory to IGF-I hormonal action. Evidence derived from the use of a truncated IGF-I analogue.
Authors: E Y Adashi, C E Resnick, E Ricciarelli, A Hurwitz, E Kokia, C Tedeschi, L Botero, E R Hernandez, R G Rosenfeld, C Carlsson-Skwirut
Journal: Journal of Clinical Investigation (1992)

An increasing body of information now suggests that insulin-like growth factor (IGF) binding proteins (BPs) may serve as antigonadotropins at the level of the ovary. It is the objective of the present communication to evaluate the functional role of endogenous (granulosa cell-derived) IGFBPs by exploiting the unique properties of des(1-3)IGF-I, a naturally occurring IGF-I analogue characterized as a weak ligand of IGFBPs but not of type I IGF receptors. Given IGFBP-replete circumstances, des(1-3)IGF-I proved more potent (10-fold) than its intact counterpart in promoting the follicle stimulating hormone (FSH)-stimulated accumulation of progesterone by cultured rat granulosa cells. In contrast, des(1-3)IGF-I proved virtually equipotent to the unmodified principle under IGFBP-deplete circumstances. Taken together, these findings are in keeping with the notion and that the apparently enhanced potency of des(1-3)IGF-I (under IGFBP-replete conditions) is due to its diminished affinity for endogenously generated IGFBPs and that rat granulosa cell-derived IGFBPs are inhibitory to IGF (and thus inevitably to gonadotropin) hormonal action. Accordingly, the reported ability of gonadotropins to attenuate IGFBP release by granulosa cells may be designed to enhance the bioavailability of endogenously generated IGFs in the best interest of ovarian steroidogenesis.
Der Gemeinsame Rorschach-Versuch, ein Mittel zum Studium von Partnerbeziehungen
Authors: J. Willi
Journal: Psychotherapy and Psychosomatics (1968)

Research Articles| February 12 2010 Der Gemeinsame Rorschach-Versuch, ein Mittel zum Studium von Partnerbeziehungen Subject Area: Psychiatry and Psychology J. Willi J. Willi Psychiatrische Universitätsklinik Burghölzli, Zürich (Direktor: Prof. Dr. M. Bleuler) Search for other works by this author on: This Site PubMed Google Scholar Psychother Psychosom (1968) 16 (6): 375–384. https://doi.org/10.1159/000285969 Article history Published Online: February 12 2010 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation J. Willi; Der Gemeinsame Rorschach-Versuch, ein Mittel zum Studium von Partnerbeziehungen. Psychother Psychosom 1 June 1968; 16 (6): 375–384. https://doi.org/10.1159/000285969 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsPsychotherapy and Psychosomatics Search Advanced Search This content is only available via PDF. 1968Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Article PDF first page preview Close Modal You do not currently have access to this content.
Hyperosmolality related to propylene glycol in an infant.
Authors: S Murch, K Costeloe
Journal: BMJ (1990)

Hypothyroidism in polymyalgia rheumatica and giant cell arteritis SIR,-The paper by Dr B Dasgupta and colleagues showing no association between polymyalgia rheumatica or giant cell arteritis and hypothyroidism in 77 patients' agreed with our experience.After reading of such an association,2 we measured the thyroid function of patients being followed up for these conditions in our rheumatology clinic.
Vascular and Lymphatic Absorption of Radioactive Albumin from the Lungs
Authors: W. J. Gillespie, G. J. de Lee
Journal: Cardiovascular Research (1967)

Plasma absorption studies were carried out on normal dogs and dogs with heart failure, with and without total lymph drainage from thoracic duct and right lymph ducts, after radioactive iodinated albumin (RISA) had been instilled into the lungs to explore a possible method for an indirect measurement of lung lymph flow. RISA entered plasma from the lungs mainly through the bloodstream. Its concentration in lung lymph correlated poorly with total lung lymph flow. More RISA entered the plasma than is normal in heart failure, implying an increased alveolar capillary permeability to protein in pulmonary oedema.
A new lymphocyte-activating determinant locus expressed on T cells, and mapping in I-C subregion.
Authors: K Okuda, C S David
Journal: The Journal of Experimental Medicine (1978)

A new lymphocyte-activating determinant (Lad) locus expressed on T cells was identified, mapping in the I-C subregions of H-2k and H-2d haplotypes. The mixed lymphocyte reaction stimulation could be inhibited by anti-Ia sera made in strains incompatible for this chromosomal segment. Experiments with purified lymphocyte cell populations suggested that this Lad locus was expressed on T cells. Further, only purified T cells were able to remove the inhibiting activity from the anti-Ia sera. I-C subregion gene(s) seem to code for products selectively expressed on a subpopulation of T cells.