THE RESULTS OF THE TREATMENT WITH TOLBUTAMIDE OF 200 DIABETIC PATIENTS: A DISCUSSION OF SECONDARY FAILURE
Authors: J M MOSS, D E DELAWTER, J J CANARY
Journal: Annals of Internal Medicine (1959)

Article1 June 1959THE RESULTS OF THE TREATMENT WITH TOLBUTAMIDE OF 200 DIABETIC PATIENTS: A DISCUSSION OF SECONDARY FAILUREJAMES M. MOSS, M.D., F.A.C.P., DEWITT E. DELAWTER, M.D., JOHN J. CANARY, M.D.JAMES M. MOSS, M.D., F.A.C.P.Search for more papers by this author, DEWITT E. DELAWTER, M.D.Search for more papers by this author, JOHN J. CANARY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-6-1407 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSatisfactory control of diabetes mellitus has been reported in more than half of the patients treated with tolbutamide.1, 2, 3 After an initial period of good response a few patients develop persistent hyperglycemia unresponsive to an increased dose. This secondary failure to respond has been reported in 0.3%4 to 14%5 of all patients. The incidence may be higher when more patients have been followed for a longer period of time. The records of 200 tolbutamide-treated patients have been reviewed in an effort to evaluate this and other problems.METHODS AND MATERIALSThe patients in the early part of this series...Bibliography1. Dolger H: Experience with the tolbutamide treatment of five hundred cases of diabetes on an ambulatory basis, Ann. New York Acad. Sc. 71: 275-279 (July 10) 1957. CrossrefMedlineGoogle Scholar2. WilliamsHenley RHED: Recent studies relative to the treatment of diabetes, Arch. Int. Med. 99: 501-518 (Apr.) 1957. CrossrefGoogle Scholar3. Breneman JC: Clinical use of tolbutamide (Orinase) in office and home care of diabetics, J. A. M. A. 164: 627-633 (June 7) 1957. CrossrefMedlineGoogle Scholar4. StotterDorfmullerEndres FSMFW: Report on experiences in one and a half years of oral treatment of diabetes with tolbutamide, Ann. New York Acad. Sc. 71: 280-290 (July 10) 1957. CrossrefMedlineGoogle Scholar5. PfeifferSchoefflingSteigerwaldTreaserOtt EKHGM: The problem of secondary failure during the treatment of diabetes with D860, Deutsche med. Wchnschr. 82: 1528-1530 (Sept.) 1957. CrossrefMedlineGoogle Scholar6. DuncanLeeYoung GCCTJK: Clinical experiences with the sulfonylurea compounds, Ann. New York Acad. Sc. 71: 233-238 (July 10) 1957. CrossrefMedlineGoogle Scholar7. HurwitzMcCuistion DA: Tolbutamide: a double-blind study of its effect in diabetes, New England J. Med. 257: 931-933 (Nov. 7) 1957. CrossrefMedlineGoogle Scholar8. O'DonovanForistLewisMillerDulinLarson CAACWLWEEJ: Tolbutamide: oral control of diabetes mellitus, Scientific exhibit, American Medical Association Meeting, June, 1957, New York, N. Y. Google Scholar9. VolkGoldnerWeisenfeldLazarus BWMGSS: Functional and histological studies concerning the action of sulfonylureas, Ann. New York Acad. Sc. 71: 141-151 (July 10) 1957. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C.*Received for publication August 18, 1958.From the Diabetic Clinic of the Georgetown University Hospital, Washington, D. C.†This study was partially supported by a grant from the Upjohn Company, Kalamazoo, Michigan.‡Part of work done during tenure of postdoctoral research fellowship, National Heart Institute, National Institutes of Health.Requests for reprints should be addressed to James M. Moss, M.D., 3805 Florence Drive, Alexandria, Virginia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAn Evaluation of Secondary Failure to Tolbutamide TherapyOral treatment in diabetesAssessment of Treatment with Tolbutamide in Diabetes Mellitus1Orale Diabetestherapie und ihre experimentellen GrundlagenManagement of diabetes mellitusMETAHEXAMIDE IN DIABETES THERAPY 1 June 1959Volume 50, Issue 6Page: 1407-1417KeywordsDiabetes mellitusFellowshipsHeartHospitalsHyperglycemiaIngestionInsulinOintmentsOverweight ePublished: 1 December 2008 Issue Published: 1 June 1959 PDF downloadLoading ...