tbuckley/cabot-search huggingface dataset:
Internet Medical Resources
Authors: Robert H. Dolin
Journal: Annals of Internal Medicine (1996)

Letters1 February 1996Internet Medical ResourcesRobert H. Dolin, MDRobert H. Dolin, MDUniversity of California, Los Angeles, School of Medicine; Los Angeles, CA 90024Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-3-199602010-00031 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Dr. Glowniak [1] presents a somewhat toneddown view of the Internet compared with that expressed in an earlier article in which he stated “The Internet has evolved … to an information resource from which nearly all physicians can benefit. The medical applications on the Internet have become an unparalleled information resource that can be of great value to researchers, educators, and clinicians” [2]. The message in his Annals article is that “computer networks in general and the Internet in particular are likely to play more important roles in many aspects of medicine in the future.” However, many ...References1. Glowniak JV. Medical resources on the Internet. Ann Intern Med. 1995; 123:123-31. Google Scholar2. Glowniak JV, Bushway MK. Computer networks as a medical resource: Accessing and using the Internet. JAMA. 1994; 271:1933-9. Google Scholar3. Giuse NB, Huber JT, Giuse DA, Brown CW, Bankowitz RA, Hunt S. Information needs of health care professionals in an AIDS outpatient clinic as determined by chart review. Journal of the American Medical Informatics Association. 1994; 1:395-403. Google Scholar4. Patrick TB, Springer GK. Classifying and identifying servers for biomedical information retrieval. In: Proceedings of the Symposium on Computer Applications in Medical Care. Philadelphia: Hanley & Belfus; 1994;93-7. Google Scholar5. Miller PL, Frawley SJ, Wright L, Roderer NK, Powsner SM. Lessons learned from a pilot implementation of the UMLS Information Sources Map. Journal of the American Medical Informaties Association. 1995; 2:102-15. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of California, Los Angeles, School of Medicine; Los Angeles, CA 90024 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1996Volume 124, Issue 3Page: 375KeywordsComputer networksForecastingInformation technologyInternetLibrariesSpecificity Issue Published: 1 February 1996 CopyrightCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Iatrogenic Pneumothorax Incidentally Detected by Ga-67 Imaging
Authors: YUSUKE INOUE, TOHRU OHTAKE, SHINICHI INOH, JUNICHI NISHIKAWA, KOHKI YOSHIKAWA, YASUHITO SASAKI
Journal: Clinical Nuclear Medicine (1998)

A 61-year-old man with metastatic lesions in the right inguinal lymph nodes had Ga-67 imaging to localize a primary tumor site. The Ga-67 study showed a photopenic area in the peripheral region of the left hemithorax. A chest radiograph showed a left pneumothorax. A catheter had been inserted from the left subclavian artery, and the pneumothorax was considered iatrogenic.
Successful switch to dabrafenib after vemurafenib-induced toxic epidermal necrolysis
Authors: G. Jeudy, S. Dalac-Rat, B. Bonniaud, A. Hervieu, T. Petrella, E. Collet, P. Vabres
Journal: British Journal of Dermatology (2014)

Journal Article Successful switch to dabrafenib after vemurafenib‐induced toxic epidermal necrolysis Get access G. Jeudy, G. Jeudy Service de Dermatologie Centre Hospitalier Universitaire 21000 Dijon France Search for other works by this author on: Oxford Academic Google Scholar S. Dalac‐Rat, S. Dalac‐Rat Service de Dermatologie Centre Hospitalier Universitaire 21000 Dijon France Search for other works by this author on: Oxford Academic Google Scholar B. Bonniaud, B. Bonniaud Service de Dermatologie Centre Hospitalier Universitaire 21000 Dijon France Search for other works by this author on: Oxford Academic Google Scholar A. Hervieu, A. Hervieu Service de Dermatologie Centre Hospitalier Universitaire 21000 Dijon France Search for other works by this author on: Oxford Academic Google Scholar T. Petrella, T. Petrella Service d'Anatomie Pathologique Centre Hospitalier Universitaire 21000 Dijon France Search for other works by this author on: Oxford Academic Google Scholar E. Collet, E. Collet Service de Dermatologie Centre Hospitalier Universitaire 21000 Dijon France Search for other works by this author on: Oxford Academic Google Scholar P. Vabres P. Vabres Service de Dermatologie Centre Hospitalier Universitaire 21000 Dijon France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 172, Issue 5, 1 May 2015, Pages 1454–1455, https://doi.org/10.1111/bjd.13522 Published: 01 May 2015
Statin Therapy and Risks for Death and Hospitalization in Chronic Heart Failure
Authors: Alan S. Go, Wendy Y. Lee, Jingrong Yang, Joan C. Lo, Jerry H. Gurwitz
Journal: JAMA (2006)

ContextWhether statin therapy has beneficial effects on clinical outcomes in patients with heart failure is unclear.Objective To evaluate the association between initiation of statin therapy and risks for death and hospitalization among adults with chronic heart failure.Design, Setting, and Patients Propensity-adjusted cohort study of adults diagnosed with heart failure who were eligible for lipid-lowering therapy but had no previous known statin use, within an integrated health care delivery system in northern California between January 1, 1996, and December 31, 2004.Statin use was estimated from filled outpatient prescriptions in pharmacy databases. Main Outcome MeasuresAll-cause death and hospitalization for heart failure during a median of 2.4 years of follow-up.We examined the independent relationships between statin therapy and risks for adverse events overall and stratified by the presence or absence of coronary heart disease after multivariable adjustment for potential confounders. ResultsAmong 24 598 adults diagnosed with heart failure who had no prior statin use, those initiating statin therapy (n=12 648; 51.4%) were more likely to be younger, male, and have known cardiovascular disease, diabetes, and hypertension.There were 8235 patients who died.Using an intent-to-treat approach, incident statin use was associated with lower risks of death (age-and sex-adjusted rate of 14.5 per 100 person-years with statin therapy vs 25.3 per 100 person-years without statin therapy; adjusted hazard ratio, 0.76 [95% confidence interval, 0.72-0.80])and hospitalization for heart failure (age-and sex-adjusted rate of 21.9 per 100 person-years with statin therapy vs 31.1 per 100 person-years without statin therapy; adjusted hazard ratio, 0.79 [95% confidence interval, 0.74-0.85])even after adjustment for the propensity to take statins, cholesterol level, use of other cardiovascular medications, and other potential confounders.Incident statin use was associated with lower adjusted risks of adverse outcomes in patients with or without known coronary heart disease.Conclusion Among adults diagnosed with heart failure who had no prior statin use, incident statin use was independently associated with lower risks of death and hospitalization among patients with or without coronary heart disease.
Use of drug treatment services in England is rising
Authors: Roger Dobson
Journal: BMJ (2007)

Almost 200 000 people were in contact with specialist drug treatment services in England in 2006-7. This was a rise of 10% on the previous year and was 130% higher than the figure eight years ago, figures from the National Treatment Agency for Substance Misuse show.

The data show that a total of 195 464 people used the services in 2006/7 and 177 055 the previous year.

“More people are receiving the treatment they need, and three out of four are also …
'Catching cold' may not be as easy as it seems
Authors: Chris Anne Raymond
Journal: JAMA (1986)

Colds are transmitted primarily through hand-to-hand contact, not through airborne particles, at least when rhinoviruses and respiratory syncytial viruses are involved, according to investigators at the University of Virginia (<i>Ann Intern Med</i>1978;88:463-467;<i>J Pediatr</i>1981;99:100-103;<i>Am J Epidemiol</i>1982;116:828-833). Respiratory viruses theoretically can be transmitted in three ways: small particle aerosols (primarily from coughing), large particle aerosols (coughing and sneezing), and direct or indirect contact with objects contaminated with virus. Transmission starts with viral shedding, most commonly from nasal secretions. Cold viruses are ten to 100 times more prevalent in the nasal than in the pharyngeal mucosa. Knowing this, J. Owen Hendley, MD, and Jack M. Gwaltney, Jr, MD, both of the University of Virginia, Charlottesville, began to doubt that airborne particles expelled from nasal secretions could be the primary means of transmission. They set up a series of experiments, alternately testing the three likely transmission routes (<i>J Respir</i>
Factor Structure of a Spanish Version of the Toronto Alexithymia Scale
Authors: Gustavo Rodrigo, Mabel Lusiardo
Journal: Psychotherapy and Psychosomatics (1992)

A Spanish adaptation of the Toronto Alexithymia Scale (TAS) was factor-analyzed and its factor solution compared with the Canadian version of this test. A principal factor analysis was performed, revealing four factors of alexithymia. These factors are quite similar to those found through factor analysis of the TAS for the Canadian sample. A discussion of the factor structure is presented.
Disappearance of a large pedunculated polyp after diagnostic colonoscopy
Authors: H. Lee, W. Moon, S. Park, M. Park, H. Kim, J. Choi
Journal: Endoscopy (2013)

A 66-year-old Korean man was referred for colonic polypectomy. A colonoscopy performed at another hospital 1 week previously had revealed a large pedunculated polyp with an erythematous surface that was occupying almost the entire lumen in the mid-sigmoid colon ([Fig. 1]). The polyp appeared hyperplastic, and no biopsy was performed.
Beyond Pairwise Distances: Neighbor-Joining with Phylogenetic Diversity Estimates
Authors: Dan Levy, Ruriko Yoshida, Lior Pachter
Journal: Molecular Biology and Evolution (2005)

The "neighbor-joining algorithm" is a recursive procedure for reconstructing trees that is based on a transformation of pairwise distances between leaves. We present a generalization of the neighbor-joining transformation, which uses estimates of phylogenetic diversity rather than pairwise distances in the tree. This leads to an improved neighbor-joining algorithm whose total running time is still polynomial in the number of taxa. On simulated data, the method outperforms other distance-based methods. We have implemented neighbor-joining for subtree weights in a program called MJOIN which is freely available under the Gnu Public License at http://bio.math.berkeley.edu/mjoin/.
Gangrene of the Breast — A Complication of Anticoagulant Therapy
Authors: Charles S. Kipen
Journal: New England Journal of Medicine (1961)

THE rarity of gangrene of the breast is attested by the fact that this entity is not mentioned in most of the recent textbooks or monographs on diseases of the breast.Only occasional reports1 2 3 4 5 6 7 8 have appeared describing cases of gangrene of the mammary gland attributed to various etiologic factors such as diabetes, infectious organisms and toxic agents, plastic surgical procedures and thrombophlebitis.This report was prompted by the observation of 2 cases in which gangrene of an entire breast followed the administration of anticoagulant drugs. The numerous hemorrhagic complications and dangers of anticoagulant therapy are now well known, and case . . .
A Comparison of Mongoloid Children
Authors: Robert B. Kugel
Journal: JAMA (1961)

Mongoloid children and their families were studied retrospectively in order to contrast the development of 21 such children institutionalized before they were one year old with that of 34 reared in their own homes. The 34 children kept at home acquired motor and speech skills earlier, and 20 of these families were considered to have made a good adjustment. The fact that milder cases predominated in this group made interpretation of the results difficult, but it is concluded that there are advantages in keeping the mongoloid child at home, at least until the age of 5 years, and that the physician should consider all family factors before recommending institutionalization.
Angiotensin-Converting Enzyme Gene Polymorphism Is Associated With Myocardial Infarction but Not With Development of Coronary Stenosis
Authors: Erwin Ludwig, Patrice S. Corneli, Jeffrey L. Anderson, Hiram W. Marshall, Jean-Marc Lalouel, R. H. Ward
Journal: Circulation (1995)

Background Although both genetic and nongenetic factors contribute to the pathogenesis of coronary artery disease, the identification of specific genetic lesions has lagged behind the identification of critical environmental risk factors. A reported association between myocardial infarction (MI) and the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in European men suggests a critical role for this genomic region. However, the generality of this association remains to be determined. It also is not clear at what stage in disease progression the association with the ACE I/D polymorphism becomes important. Methods and Results We evaluated the ACE I/D polymorphism in patients who had undergone coronary angiography (402 men and 295 women) and in 203 representative control subjects. After polymerase chain reaction amplification, genotypes were determined by agarose gel sizing and by hybridization with allele-specific oligonucleotides. After patients were categorized by the degree of coronary artery stenosis and the occurrence of an MI, the distribution of ACE I/D genotypes was evaluated by log linear analysis. Patients were genetically representative of the regional population, and patients with &gt;60% stenosis of their coronary arteries had the same distribution of ACE I/D genotypes as did patients with &lt;10% stenosis. However, among patients with stenosis, the occurrence of an MI was significantly associated with the D allele in all patients (odds ratio [OR], 1.59; P =.002) and in men alone (OR, 1.63; P =.006). The lack of significance in women (OR, 1.40; P =.263) is probably due to the fact that only 36 women in the present study had experienced an MI. Furthermore, the association between MI and the ACE I/D polymorphism was independent of blood pressure, smoking habits, and body mass index. Conclusions Segregation of the ACE I/D polymorphism is a pervasive genetic risk factor for MI in whites but has no evident effect on the events leading to stenosis of the coronary arteries. This suggests that risk of MI is influenced by two independent processes—atherogenesis that leads to coronary stenosis followed by conversion to MI. The renin-angiotensin system appears to confer significant risk of infarction by influencing the conversion to MI but has no apparent effect on the development of atherostenosis.
"Achieving a balance" and meeting the "safety net".
Authors: A. Scotland, S. McKenzie
Journal: BMJ (1989)

A central feature of drugs of abuse is to induce gene expression in discrete brain structures that are critically involved in behavioral responses related to addictive processes. Although extracellular signal-regulated kinase (ERK) has been implicated in several neurobiological processes, including neuronal plasticity, its role in drug addiction remains poorly understood. This study was designed to analyze the activation of ERK by cocaine, its involvement in cocaine-induced early and long-term behavioral effects, as well as in gene expression. We show, by immunocytochemistry, that acute cocaine administration activates ERK throughout the striatum, rapidly but transiently. This activation was blocked when SCH 23390 [a specific dopamine (DA)-D1 antagonist] but not raclopride (a DA-D2 antagonist) was injected before cocaine. Glutamate receptors of NMDA subtypes also participated in ERK activation, as shown after injection of the NMDA receptor antagonist MK 801. The systemic injection of SL327, a selective inhibitor of the ERK kinase MEK, before cocaine, abolished the cocaine-induced ERK activation and decreased cocaine-induced hyperlocomotion, indicating a role of this pathway in events underlying early behavioral responses. Moreover, the rewarding effects of cocaine were abolished by SL327 in the place-conditioning paradigm. Because SL327 antagonized cocaine-induced c-fos expression and Elk-1 hyperphosphorylation, we suggest that the ERK intracellular signaling cascade is also involved in the prime burst of gene expression underlying long-term behavioral changes induced by cocaine. Altogether, these results reveal a new mechanism to explain behavioral responses of cocaine related to its addictive properties.
Effect of inhibition of Helicobacter pylori urease activity by acetohydroxamic acid on serum gastrin in duodenal ulcer subjects.
Authors: A M el Nujumi, C A Dorrian, R S Chittajallu, W D Neithercut, K E McColl
Journal: Gut (1991)

The mechanism of the hypergastrinaemia associated with Helicobacter pylori infection is unknown. It may be an effect of the ammonia produced by the bacterium near the antral epithelial surface. We have examined the effect on serum gastrin of inhibiting H pylori urease activity with acetohydroxamic acid in six duodenal ulcer patients. On day 1 the fasted patients received placebo tablets at 8 am, a peptide meal at 10 am, and a 14C urea breath test at 11.30 am. The next day 750 mg acetohydroxamic acid was administered orally in place of the placebo. The median (range) 30 minute breath test value (dose/mmol CO2 X kg body wt X 100) was 152 (111-335) on day 1, but only 22 (14-95) the next day (p less than 0.03). Further studies performed in one subject confirmed that acetohydroxamic acid lowered the ammonium concentration and raised the urea concentration in gastric juice. The inhibition of urease activity and ammonia production did not result in a fall in the basal gastrin concentration or in the median integrated gastrin response to the peptide meal, which was 78 ng/1.h (range 21-222) on day 1 and 79 ng/1.h (33-207) the next day. Ten days after acetohydroxamic acid, the urea breath test values were similar to those before treatment. This study shows that the raised gastrin concentration in patients with H pylori infection is not directly related to the organism9s urease activity. It also shows that temporary suppression of H pylori urease activity does not clear the infection.
TCT-420 First- versus Second-generation Drug-Eluting Stents for the Treatment of Coronary Bifurcations
Authors: Charis Costopoulos, Azeem Latib, Toru Naganuma, Sandeep Basavarajaiah, Mauro Carlino, Alaide Chieffo, Santo Ferrarello, Filippo Figini, Masanori Kawaguchi, Matteo Montorfano, Charbel Naim, Alessandro Sticchi, Antonio Colombo
Journal: Journal of the American College of Cardiology (2013)
Priority patients in a pandemonium
Authors: R. Wheeler
Journal: BMJ (2009)

Should swine flu mutate into a more sinister disease than its present form, very large numbers of sick patients will present at the reception of your practice or your hospital demanding treatment. Some of them may be your colleagues or their families. Will you give them priority? 

While the available facilities exceed the demand, all patients will doubtless be dealt with in an orderly manner. But when the numbers exceed the facilities, triage will be implemented, selecting those who will benefit from treatment in favour of those in whom treatment may ultimately be futile. This is a well understood process, dating back through centuries of warfare, and is considered a measured response to a lack of resources. But warfare tends to generate a wide spectrum of injury severity. This makes differentiation between those who can wait for treatment, those who cannot, and those for whom treatment will make little difference relatively straightforward, at least in theory. However, an overwhelming …
Cost-Efficacy of Surgically Induced Weight Loss for the Management of Type 2 Diabetes
Authors: Catherine L. Keating, John B. Dixon, Marjory L. Moodie, Anna Peeters, Julie Playfair, Paul E. O'Brien
Journal: Diabetes Care (2009)

OBJECTIVE To determine the within-trial cost-efficacy of surgical therapy relative to conventional therapy for achieving remission of recently diagnosed type 2 diabetes in class I and II obese patients. RESEARCH DESIGN AND METHODS Efficacy results were derived from a 2-year randomized controlled trial. A health sector perspective was adopted, and within-trial intervention costs included gastric banding surgery, mitigation of complications, outpatient medical consultations, medical investigations, pathology, weight loss therapies, and medication. Resource use was measured based on data drawn from a trial database and patient medical records and valued based on private hospital costs and government schedules in 2006 Australian dollars (AUD). An incremental cost-effectiveness analysis was undertaken. RESULTS Mean 2-year intervention costs per patient were 13,400 AUD for surgical therapy and 3,400 AUD for conventional therapy, with laparoscopic adjustable gastric band (LAGB) surgery accounting for 85% of the difference. Outpatient medical consultation costs were three times higher for surgical patients, whereas medication costs were 1.5 times higher for conventional patients. The cost differences were primarily in the first 6 months of the trial. Relative to conventional therapy, the incremental cost-effectiveness ratio for surgical therapy was 16,600 AUD per case of diabetes remitted (currency exchange: 1 AUD = 0.74 USD). CONCLUSIONS Surgical therapy appears to be a cost-effective option for managing type 2 diabetes in class I and II obese patients.
Fibrinous peritonitis in a patient with rheumatoid arthritis
Authors: R Kapoor, E Dean, T Palferman, Z Khan
Journal: Journal of the Royal Society of Medicine (2005)

Fewer than a hundred cases of Erdheim-Chester disease have been reported. 34][5] The most common presenting complaint is bone pain along with general symptoms such as fever, weight loss and weakness. 4Hydronephrosis is due to infiltration of retroperitoneal fat. 7he prognosis depends largely on the extent and distribution of extraosseous disease.Systemic corticosteroids, chemotherapy and radiation treatment have all been used but formal trials are lacking.
Gastroscopy in the Estimation of Maximal Acid Output
Authors: H. Petersen, J. Myren
Journal: Endoscopy (1973)

The maximal acid output (MAO) was suggested from the endoscopic appearance of the stomach in 105 consecutive patients. The endoscopist had no knowledge of the patient. – A significant correlation (r = 0.58) was found between the suggested MAO and the MAO measured in a subsequent secretory test. The comparison of measured and suggested values for MAO and the gradings of the endoscopic characteristics, showed that the gastroscopic evaluation of mucosal foldings, injection, mucus covering and artificial bleeding, is of value in predicting acid secretory capacity.