Involutional Osteopenia: Current Concepts
Authors: DAVID L. THOMSON
Journal: Annals of Internal Medicine (1976)

Clinical Review1 December 1976Involutional Osteopenia: Current ConceptsDAVID L. THOMSON, M.D., BOY FRAME, M.D., F.A.C.P.DAVID L. THOMSON, M.D.Search for more papers by this author, BOY FRAME, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-6-789 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInvolutional osteopenia is the most common metabolic bone disorder affecting the elderly population. Improved diagnostic techniques now allow for earlier detection of a decrease in bone mass than is possible with routine skeletal roentgenograms. Methods developed for quantitating bone remodeling have given new insight to the mechanisms involved in age-related skeletal loss. Theories of pathogenesis include [1] inadequate skeletal acquisition during youth, [2] dietary deficiencies of calcium and vitamin D, [3] hormonal imbalance, and [4] local factors influencing skeletal remodeling, particularly at the endosteal envelope. Numerous agents affecting bone remodeling have been used to treat involutional osteopenia, but none has been proved to restore bone mass. New programs involving combinations of agents give promise for increasing bone mineral content and, it is hoped, reducing fracture rate....References1. FROST H: Bone Remodeling Dynamics. Springfield, Charles C Thomas, 1963 Google Scholar2. ISKRANT A and SMITH R: Osteoporosis in women 45 years and over related to subsequent fractures. Public Health Rep 84:33-38, 1969 CrossrefMedlineGoogle Scholar3. ALFFRAM P: An epidemiologic study of cervical and trochanteric fractures of the femur in an urban population. Acta Orthop Scand [Suppl] 65:1-109, 1964 CrossrefGoogle Scholar4. 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THOMSON, M.D.; BOY FRAME, M.D., F.A.C.P.Affiliations: Detroit, Michigan▸From the Department of Medicine, Henry Ford Hospital; Detroit, Michigan. 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