tbuckley/cabot-search huggingface dataset:
TUBERCULOUS PERICARDITIS: A REPORT OF THREE CASES TREATED WITH STREPTOMYCIN
Authors: Robert P. Natelson
Journal: Annals of Internal Medicine (1951)

Article1 May 1951TUBERCULOUS PERICARDITIS: A REPORT OF THREE CASES TREATED WITH STREPTOMYCINROBERT P. NATELSONROBERT P. NATELSONSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-5-1169 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe treatment of tuberculosis had been generally supportive until Hinshaw and Feldman1 in 1945 demonstrated the efficacy of streptomycin in human tuberculosis. Their report followed that of Schatz, Bugie and Waksman,2 who in 1944 demonstrated the in vitro inhibitory effect of streptomycin on the tubercle bacillus. In tuberculous pericarditis, some employed the introduction of air into the pericardial sac after the withdrawal of fluid in an effort to help decrease adhesion formation. This form of therapy has not been unequivocally accepted as effective.Reports of the use of streptomycin in tuberculous pericarditis are few in number, and only seven were...Bibliography1. HinshawFeldman HCWH: Streptomycin in treatment of clinical tuberculosis: a preliminary report, Proc. Staff Meet., Mayo Clin. 20: 313, 1945. Google Scholar2. SchatzBugieWaksman AESA: Streptomycin, a substance exhibiting antibiotic activity against gram-positive and gram-negative bacteria, Proc. Soc. Exper. Biol. and Med. 55: 66, 1944. CrossrefGoogle Scholar3. McDermottMuschenheimHadleyBunnGorman WCSJPARV: Streptomycin in the treatment of tuberculosis in humans, Ann. Int. Med. 27: 769, 1947. LinkGoogle Scholar4. Meredith HC: Streptomycin in acute tuberculous pericarditis, Am. Heart J. 37: 129, 1949. CrossrefMedlineGoogle Scholar5. JohnsonBercu RPBA: Streptomycin in the treatment of tuberculous pericarditis, Am. Rev. Tuberc. 59: 656, 1949. MedlineGoogle Scholar6. Cloetens W: Traitement a la streptomycine d'un cas de pericardite tuberculeuse, Acta clin. belg. 4: 396, 1949. CrossrefMedlineGoogle Scholar7. Jervell A: Streptomycin Behandling av TuberKuløs Pericarditt, Den Norske-Laegeforening 20: 536, 1949. Google Scholar8. MouriquandGuinetDechavanne R: Un cas de péricardite hemorrhagique tuberculeuse grave. Guérison par la streptomycine, Lyon méd. 182: 277, 1949. MedlineGoogle Scholar9. EbertFalk RVA: The use of streptomycin in the treatment of tuberculous pericarditis. Minutes of the Eighth Streptomycin Conference, Nov., 1949, p. 155. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT P. NATELSON*Received for publication September 16, 1950.From the Department of Medicine, University of Wisconsin Medical School, Madison, Wisconsin. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byErkrankungen des Perikard 1 May 1951Volume 34, Issue 5 Page: 1169-1172 Keywords Bacillus Streptomycin Tuberculosis ePublished: 1 December 2008 Issue Published: 1 May 1951 PDF downloadLoading ...
Effects of Pituitary Graft and 2-Bromo-α-ergocryptine on Mammary DNA Synthesis in Mice in Relation to Mammary Tumorigenesis2
Authors: Yanai Reiko, Nagasawa Hiroshi
Journal: JNCI Journal of the National Cancer Institute (1976)

3H-thymidine incorporation into mammary DNA as an index of mammary DNA synthesis in C3H/He virgin females was significantly higher at proestrus than at estrus and diestrus. The rise in incorporation at proestrus was completely blocked by the administration of 2-bromo-alpha-ergocryptine (Bromocriptin) 1 day before proestrus. The incorporation was maintained at a higher level than that at proestrus by pituitary grafts. The results supported the view that mammary DNA synthesis, which is stimulated by prolactin, is an important factor for mammary tumorigenesis.
Mutant NDUFV1 subunit of mitochondrial complex I causes leukodystrophy and myoclonic epilepsy
Authors: Markus Schuelke, Jan Smeitink, Edwin Mariman, Jan Loeffen, Barbara Plecko, Frans Trijbels, Sylvia Stöckler-Ipsiroglu, Lambert van den Heuvel
Journal: Nature Genetics (1999)
Complications Related to Vascular Hemostasis Devices
Authors: Jane E. Henney
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Does length of hospital stay prior to ICU admission affect mortality in COPD exacerbations
Authors: Begüm Ergan Arsava, Recai Ergün
Journal: European Respiratory Journal (2013)

AIM:  Early admission to intensive care unit (ICU) is crucial during chronic obstructive pulmonary disease (COPD) exacerbation related critical illness. But in Turkey, early admission to ICU is a problem due to inadequate number of ICU beds. In this study we wanted to evaluate whether length of hospital stay prior to ICU admission had any effect on mortality in COPD exacerbations.   METHODS:  COPD exacerbation patients were retrospectively evaluated for demographic charactheristics, admission laboratory values, length of hospital stay prior to ICU admission. Patients were divided into two groups according to length of hospital stay prior to ICU admission (early and late, divided from median).   RESULTS:  Fifty patients (38 male,12 female, mean age±standart deviation: 69.4±8.8years) were included. Median length of hospital stay prior to ICU admission was 4 days (early admission group n=37, late admission group n=13) and most of the patients in the late admission group were admitted from wards (10.8 % in early group and 46. 2 % in late group; p=0.01). When compared two groups had similar demographic and clinical charactheristics (age, sex, APACHE 2 and Glasgow coma scores, arterial blood gas analysis [pH, pCO2 and pO2], intubation rate, length of mechanical ventilation and ICU stay), but mortality was high in late admission group(27% versus 69%; p=0.02).   CONCLUSION:  In this study, COPD exacerbation patients with increased length of hospital stay prior to ICU admission had higher mortality. This may be related with inappropriate-severe patient admission to wards due to inadequate number of ICU beds.
Isolated systolic hypertension: a radical rethink
Authors: I. B Wilkinson
Journal: BMJ (2000)

The association between hypertension and a “hardening” of the pulse and apoplexy has been recognised for hundreds of years. The major problem in elderly people is isolated systolic hypertension, defined as a raised systolic pressure but normal diastolic pressure. It affects around half of people aged over 60 years.1 Originally, because isolated systolic hypertension was so common it was considered part of ageing and, like essential hypertension, benign. However, there is now compelling evidence from cross sectional, longitudinal, and randomised controlled trials that show that isolated systolic hypertension confers a substantial cardiovascularrisk.2 3 Despite this, it remains underdiagnosed and largely untreated.4 The roots of this lie in a century of overreliance on the importance of diastolic pressure and largely unjustified concerns about the potential adverse consequences of treating systolic pressure.

After the mercury sphygmomanometer …
Celtic ancestry, HLA phenotype and increased risk of skin cancer
Authors: None Long, None Darke, None Marks
Journal: British Journal of Dermatology (1998)

Individuals of Celtic ancestry are claimed to be at greater risk of skin cancer than non-Celts, and various positive and negative associations between certain human leucocyte antigen (HLA) phenotypes and the development of skin cancer have been described. The aims of this study were to determine whether any HLA phenotypes are associated either with Celtic or non-Celtic ancestry, or skin type. One thousand and ten members of the Welsh Bone Marrow Donor Registry (WBMDR), whose HLA phenotypes are known, were asked to complete a questionnaire which enquired as to their family origins and their 'Index of Celtic Ancestry' scored out of 12. Three groups were identified: non-Celts (score < 3), Celts (score > 9), and a subset of the Celts--'high scoring' Celts (score > 10). Details of hair and eye colour and skin type were also requested. Skin type and HLA-A, -B, -DR and -DQ frequencies were compared between the three groups (Celts, non-Celts and 'high scoring' Celts), and a random indigenous population of 9196 members of the WBMDR. Seven hundred and thirty-six replies were received (279 male, 457 female, mean age 31 years). One hundred and forty-four Celts, 51 'high scoring' Celts and 170 non-Celts were identified. Forty-six (32%) Celts had skin type I or II compared with 36 (21%) non-Celts (P = 0.039), and 37 (73%) 'high scoring' Celts had skin type I or II (P < 0.0001). However, there were no significant differences between the groups with regard to hair colour, eye colour or number of episodes of painful sunburn. The frequency of HLA-DR4 was 32% in the non-Celtic group, 44% in the Celtic group (not significant), and 53% in the 'high scoring' Celts (P = 0.008). However, the difference was not significant after correction. There were no significant associations between skin type and HLA phenotype. HLA-DR4 is known to be associated with an increased risk of both basal cell carcinoma and malignant melanoma and its increased frequency in Celts may be an independent risk factor for skin cancer in addition to skin type.
Risk of Cutaneous Vaccinia From Health Care Workers Who Receive Smallpox Vaccine
Authors: Leonard A. Mermel
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Modernising the NHS: Challenges to the health services: the professions
Authors: I. Allen
Journal: BMJ (2000)

This is the fourth in a series of seven articles 

“There is the challenge for the professions to strip out unnecessary demarcations, introduce more flexible training and working practices and ensure that doctors do not use time dealing with patients who could be treated safely by other health care staff.” This was the third of five challenges to the health service set out by the prime minister on 22 March, followed up by the secretary of state for health on 23 March with the announcement of six modernisation action teams to focus on the challenges. This announcement expanded on the reference to more flexibility and removing demarcations by adding “in the context of major expansion of the health care workforce.”

The challenge to the professions has been made. What are the most important things that would make a difference?

#### Summary points

Professionals are ready to change—and have already done so

NHS organisations need to listen to their staff, who know where systems go wrong

More flexible working and training are long overdue, together with proper training for multidisciplinary working

Innovation needs to be encouraged—and entrepreneurial clinicians supported

The first thing is for the government to recognise the extent to which members of the professions are ready to take on the challenge. The profile of the medical profession has changed radically in the past 10 years. Women now account for more than 50% of doctors leaving medical schools 1 and represent an increasing proportion of doctors under the age of 40, particularly in general practice. Younger doctors are much more like their contemporaries outside medicine in terms of education and aspirations than their older counterparts were.2 They deplore the traditional resistance to change of the medical profession. They want flexibility within their careers which will help them to lead a “normal life.” …
158. Transient Immunosuppresion by CTLA4Ig and Anti-CD40L Promotes Long-Term Tolerance Specifically Against HFVIII in Hemophilia A Mice Following Naked DNA Transfer
Authors: Peiqing Ye, Ling Zhou, Zhenping Shen, Arthur R. Thompson, David J. Rawlings, Hans D. Ochs, Carol H. Miao
Journal: Molecular Therapy (2004)

Persistent high-level gene expression of human factor VIII (hFVIII) has been achieved by naked DNA transfer of a liver-specific, highexpressing plasmid pBS-HCRHPI-FVIIIA in Rag2(-/-) SCID mice (Miao et al. (2003) Hum. Gene Ther. 14, 1297-1305). However, in immunocompetent hemophilia A mice, a robust immune response against FVIII that followed gene transfer led to complete inhibition of circulating FVIII activity. This immune response was shown to be mediated by antibodies against the transgene product. In this study, transient immunomodulation strategies to disrupt B- and Tcell interactions at the time of plasmid injection were tested to prevent formation of inhibitory antibodies against hFVIII. Three groups of mice (n=8) were treated with plasmid pBS-HCRHPIFVIIIA; group 1 was injected on days -1, 1, 2, 7, and 14 with a monoclonal antibody (MR1) against murine CD40 ligand; group 2 was treated on days 1 and 2 with recombinant murine CTLA4Ig; and group 3 received a combination of MR1 and CTLA4Ig using the same combined schedule and dosages. All animals treated with immunosuppression had delayed immune responses against hFVIII. However, the 8 animals treated with CTLA4Ig alone developed inhibitors 3-6 weeks post-injection. Six of 8 animals treated with MR1 developed inhibitors at 4-10 weeks; the other 2 did not develop inhibitors for up to 3 months. Most notably, 7 of 8 animals treated with the combination regimen of MR1 and CTLA4Ig failed to develop detectable inhibitors for at least 3 months. One animal developed a low titer of inhibitory antibodies that only partially blocked the functional activity of hFVIII in its plasma. All 7 animals that did not develop inhibitory antibodies against hFVIII exhibited persistent, supra-physiologic therapeutic levels of hFVIII gene expression. To evaluate whether immuno-modulation led to long-term defects in host immune function, two animals treated with the combination protocol, and two control animals not receiving immune modulatory therapy were then challenged twice 4 weeks apart with the neoantigen, bacteriophage Φ×174 (2×108 PFU/each challenge). One treated animal exhibited a normal primary and secondary response to bacteriophage. The second animal exhibited a slightly attenuated primary response and a normal response after the 2nd challenge, indicating that this transient immunosuppressive regimen did not induce a lasting immunodeficiency. These results strongly suggest that transient inhibition of co-stimulatory molecules in hFVIII plasmid-treated hemophilia A mice can promote long-term immune tolerance, specific for hFVIII without altering subsequent immune responses to T cell dependent neoantigens.
Abstract P110: Mean Daily Pedometer Step Count is Associated With Weight Loss
Authors: Christopher C Imes, Lei Ye, Yaguang Zheng, Juliet Mancino, Cynthia A Danford, Meghan Mattos, Edvin Music, Dara D Mendez, Hu Lu, Lin J Ewing, Susan M Sereika, Lora E Burke
Journal: Circulation (2015)

Introduction: Increased physical activity (PA), along with reduced energy intake, are the key strategies to achieve weight loss. However, there are challenges to obtaining accurate PA data. Many studies rely on self-report, which is easily accessible and inexpensive but is known to have numerous limitations. Pedometers are a relatively inexpensive and accessible method to objectively measure certain aspects of PA. However, their limitations include the inability to assess certain types of PA such as swimming and cycling. The purpose of this analysis was to examine the associations between self-reported PA, pedometer step count data and weight loss in a behavioral weight loss intervention. Hypotheses: 1) Self-reported PA will not be associated with weight loss. 2) Higher daily pedometer step count will be associated with greater weight loss. Methods: This was a secondary analysis of 6-month data from the Self Efficacy Lifestyle Focus (SELF) Trial. Self-reported PA was assessed using the Modifiable Activity...
Rapid purification and characterization of human platelet glycoprotein V: the amino acid sequence contains leucine-rich repetitive modules as in glycoprotein Ib
Authors: T Shimomura, K Fujimura, S Maehama, M Takemoto, K Oda, T Fujimoto, R Oyama, M Suzuki, K Ichihara-Tanaka, K Titani
Journal: Blood (1990)
Abstract P158: Relationship Between Wealth Factors and Health Status Among Hispanic/Latinos: Preliminary Findings from the HCHS/SOL Sociocultural Ancillary Study
Authors: Daniel F Lopez-Cevallos, Patricia Gonzalez, Jeff W Bethel, Sheila Castañeda, Carmen R Isasi, Frank J Penedo, Lizette Ojeda, Sonia M Davis, Diana A Chirinos, Kristine M Molina, Yanping Teng, Linda C Gallo
Journal: Circulation (2014)

Background: Studies show that wealth factors are associated with health status. Limited research has examined this association among Hispanic/Latinos of diverse backgrounds. The purpose of this study was to examine the associations between wealth factors, and subjective and objective health status. Methods: This cross-sectional study used data from 4,716 Hispanic/Latinos, 18 to 74 years, who participated in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Sociocultural Ancillary Study (SCAS). Participants provided information on wealth and “traditional” socioeconomic measures (i.e., education, occupation, income), and subjective health status (i.e., mental health [MCS] and physical health [PCS] scores of the SF-12®). Blood pressure, cholesterol, and weight and height were assessed and all medications were reviewed. Objective health status measures included: hypertension (blood pressure ≥140/90 or on antihypertensive medications); hypercholesterolemia (total cholesterol ≥240, HDL cholesterol &lt; 40, LDL cholesterol ≥ 160, or receiving cholesterol-lowering medication); and obesity (Body Mass Index ≥30). Wealth was measured using a Home Affluence Scale (HASC: range 0 - 6); ability to maintain a standard of living greater than or equal to 6 months; and having accrued savings greater than or equal to $5,000. Other factors included sociodemographic (age, sex, marital status, family size, years in the US, Short Acculturation Scale for Hispanics score), health-related (physical activity, diet) and healthcare access variables (health insurance coverage). Data analyses consisted of weighted summary statistics and multivariable linear and logistic regression models using the svy commands in Stata IC 12.1. Results: The mean HASC score was 2.9 (95%CI: 2.8-3.0). Approximately 25% (95% CI: 23-27%) of participants reported they would be able to maintain their standard of living for 6 months or more. Almost a third (29%, 95%CI: 27- 32%) had $5,000 or more in savings. Multivariable analyses showed that wealth, as measured by HASC, was positively associated with PCS score (β= 0.54, SE= 0.13, p&lt; 0.01), even after adjusting for “traditional” SES and other sociodemographic factors. In turn, wealth was not associated with MCS score or objective health status. Discussion: Results demonstrate that among Hispanic/Latinos of diverse backgrounds, a measure of wealth (HASC score) was associated with perceived physical health status (PCS score) but not other subjective (mental health status [MCS score]) or objective health status measures (i.e., hypertension, hypercholesterolemia, obesity). Future studies should address mechanisms via which wealth factors may impact health status in longitudinal designs.
Don’t include trimethoprim
Authors: Robin A Howe
Journal: BMJ (2008)

The Medicines and Healthcare Products Regulatory Agency (MHRA) moves to recommend, for the first time, that a systemic antibiotic (trimethoprim) should have its licence reclassified from prescription only medicine (POM) to pharmacy (P) availability.1 For systemic antibiotics particular concerns exist that do not apply to other medicines.

The use of antibiotics may have an adverse effect not only on the specific patient but also on the public health of the community. Quantifying the relation between antibiotic exposure and resistance …
The mRNA expression of thymosin β4 and annexin I and II in invasive cervical carcinoma
Authors: Hye-Sung Moon, Hye Won Chung, Hee Jae Cha, Hynda K. Kleinman
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4512 

Objects: Thymosin β4 promotes cell migration and is important in angiogenesis, wound healing, and tumor metastasis. Annexins are involved in signal transduction, tissue growth and differentiation, and inflammation. This study investigated the mRNA expression of thymosin β4 and annexin I and II and their relationship with the clinicopathologic factors and evaluated their clinical significance. Methods: The mRNA expression of thymosin β4 and annexin I and II was analyzed with Quantative Competitive Polymerase Chain Reaction in 11 normal cervix, 10 cervical intraepithelial neoplasia of cervix, and 34 invasive cervical carcinoma. The clinicopathologic factors were obtained from the review of patients’ charts. Results: The mRNA expression of thymosin β4 in invasive cervical carcinoma was higher than that of normal cervix and cervical intraepithelial neoplasia (p<0.05). The mRNA expression of annexin I and II in invasive cervical carcinoma was higher than that of normal cervix and cervical intraepithelial neoplasia (p<0.05). The mRNA expression was not correlated with other clinicopathologic factors. The mRNA expression of thymosin β4 was correlated with the mRNA expression of annexin I and II. Conclusion: The overexpression of thymosin β4 and annexin I and II mRNA may be a biologic marker of cervical carcinogenesis. It is possible that these proteins interact with each other during cervical carcinogenesis.
Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
Authors: Gabriel T. Liberatore, Vernice Jackson-Lewis, Slobodanka Vukosavic, Allen S. Mandir, Miquel Vila, W. Geoffrey McAuliffe, Valina L. Dawson, Ted M. Dawson, Serge Przedborski
Journal: Nature Medicine (1999)