tbuckley/cabot-search huggingface dataset:
Abstract 16766: Associations Between Neighborhood Characteristics and Inflammation: The Morehouse and Emory Team Up to Eliminate Health Disparities (META-Health) Study
Authors: Jia Shen, Alanna Morris, Aurelian Bidulescu, Sandra Dunbar, Viola Vaccarino, Laurence Sperling, Gary Gibbons, Arshed Quyyumi
Journal: Circulation (2014)

Background: A growing body of evidence suggests that neighborhood characteristics may contribute to cardiovascular outcomes. Systemic inflammation has emerged as a cardiovascular disease risk factor. Inflammatory pathways may contribute to neighborhood effects on cardiovascular disease risk. We aimed to examine the association between neighborhood characteristics and inflammatory mediators relevant to cardiovascular pathophysiology: interleukin-6 (IL-6), tumor necrosis factors-α (TNFα) and C-reactive protein (CRP) in a biracial cohort from the southeastern United States. Methods: Subjects were 580 men and women between 30-90 years of age (Caucasian = 47.8%, African-American = 52.2%). Neighborhood environment, walkability, and cohesion were assessed using validated questionnaires. Plasma concentrations of IL-6, TNFα, and CRP were measured from blood samples. Results: Participants from neighborhoods in the lowest (worst) tertile of environment had higher concentrations of IL-6 (p = 0.002), TNFα (p = 0.025),...
CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome
Authors: Jose Marcelino, John D. Carpten, Wafaa M. Suwairi, Orlando M. Gutierrez, Stuart Schwartz, Christiane Robbins, Raman Sood, Izabela Makalowska, Andy Baxevanis, Brian Johnstone, Ronald M. Laxer, Lawrence Zemel, Chong Ae Kim, J. Kenneth Herd, Johannes Ihle, Cal Williams, Mark Johnson, Vidya Raman, Luís Garcia Alonso, Decio Brunoni, Amy Gerstein, Nickolas Papadopoulos, Sultan A. Bahabri, Jeffrey M. Trent, Matthew L. Warman
Journal: Nature Genetics (1999)
Oleogranulomatous response in lymph nodes associated with emollient use in Netherton's syndrome
Authors: None Cockayne, None Lee, None Harrington
Journal: British Journal of Dermatology (1999)

Paraffin‐based emollients are widely used in dermatological practice and are not usually absorbed through the skin. We report a case where transcutaneous transfer did occur in the context of damaged skin in Netherton's syndrome, resulting in a reversible lymphadenopathy.
Molecular characterization of Echinococcus granulosus in south-eastern Romania: evidence of G1–G3 and G6–G10 complexes in humans
Authors: L. Piccoli, C. Bazzocchi, E. Brunetti, P. Mihailescu, C. Bandi, B. Mastalier, I. Cordos, M. Beuran, L.G. Popa, V. Meroni, F. Genco, C. Cretu
Journal: Clinical Microbiology and Infection (2012)
Group Calls for Stricter Rules for Assisted Reproduction, Ban of "Extreme" Technologies
Authors: Brian Vastag
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mumps in a community with low vaccination coverage in the Netherlands
Authors: I Karagiannis, A van Lier, R van Binnendijk, H Ruijs, E Fanoy, M  A E Conyn-Van Spaendonck, H de Melker, S Hahné
Journal: Eurosurveillance (2008)

The incidence of mumps in the Netherlands has increased since August 2007. Until mid May 2008, 89 individuals were found positive for mumps virus infection by laboratory testing at the Centre for Infectious Diseases Control (CIb) of the Dutch National Institute for Public Health and the Environment (RIVM), compared to less than 10 cases per year between 2005 and 2007. Mumps is not a notifiable disease in the Netherlands and surveillance is mainly based on monitoring laboratory test requests and their results offered by the CIb and other laboratories. As only a minority of cases is offered laboratory testing, however, the extent of the current mumps outbreak is unknown.
Argon plasma coagulation in treatment of post intubation tracheal stenosis
Authors: HamidReza Jabbardarjani, Arda Kiani, Negar Sheikhi, Mohammadreza Masjedi
Journal: European Respiratory Journal (2012)

Background and objectives:Acquired tracheal stenosis can be created by various causes.The most common cause of acquired non-malignant tracheal stenosis is endotracheal intubation,even for a short period.Argon plasma coagulation(APC) is a non-contact method of thermal hemostasis which can be used easily and fast and has low depth of penetration.Therefore,we decided to evaluate efficacy of this method in treatment of Tracheal stenosis.  Methods: This study is single blinded.Subjects were patients with tracheal stenosis after endotracheal intubation who were selected by non-probability sampling in bronchoscopy unit of Masih Daneshvari Hospital.First,for each patient,a diagnostic flexible bronchoscopy was performed to identify the type,location,and severity of the stenosis.Then, under general anesthesia,patients underwent rigid bronchoscopy.After that,the stenosis was removed as possible by APC device.After two weeks,a pulmonary function test(PFT)was done to check the obstructive signs.  Results: Of all 34 patients,24 were asymptomatic for more than 1 year and responded to treatment(70/6%),5 were asymptomatic for more than 10 months and less than 12 months(14/7%)and 5 did not have asymptomatic period more than 10 months,and did not respond to treatment.In follow-up PFT,FEV1 in all patients who were asymptomatic for more than 10 months (29 patients) showed a significant progress.(At the end of the period,FEV1 was more than 90% in 27 patients and 70-90% in 2 patients.)  Conclusion: On the whole, although the surgical treatment remains the main treatment of tracheal stenosis after intubation,if this method is not possible for any reason,APC is useful as a safe and effective method.
112. Gene Transfer into a Hematopoietic Cell Line Using a Helper-Dependent Adenoviral Vector with the Chimeric Ad5/35 Fiber
Authors: Michael A. Balamotis, Katie Huang, Ko Mitani
Journal: Molecular Therapy (2004)

Certain human cell populations have remained difficult to infect with vectors based on human adenovirus (Ad) serotype 5 due to their lack of CAR receptor. Recently, a chimeric Ad5/35 fiber, comprising of the Ad5 tail domain and the Ad35 knob and shaft domains, was created. This chimeric fiber utilizes CD46 as a receptor and displays an altered tropism from Ad5. We incorporated this chimeric fiber into a helper-dependent adenovirus vector (HD AdV) system and compared HD to E1-deleted (ED) vectors by transgene expression, cell transduction efficiency, and cytotoxicity.
Getting research findings into practice: Finding information on clinical effectiveness
Authors: J. Glanville, M. Haines, I. Auston
Journal: BMJ (1998)

This is the third in a series of eight articles analysing the gap between research and practice Series editors: Andrew Haines and Anna Donald There is increasing pressure on healthcare professionals to ensure that their practice is based on evidence from good quality research, such as randomised controlled trials or, preferably, systematic reviews of randomised controlled trials and trials of other study designs. This pressure comes from various sources. The evidence based healthcare movement encourages a questioning and reflective approach to clinical practice and emphasises the importance of lifelong learning. Thus, good access to research based evidence is necessary. Many governments are encouraging the development of evidence based medicine because its advantages are understood, especially in terms of improved efficiency in the delivery of health care through the identification of effective treatments.12 There are also indications that legal decisions may take account of whether research evidence and clinical guidelines were adhered to.34 Better informed consumers may provide another incentive for clinicians to be more aware of research findings. Clinicians will need to be able to access information on clinical effectiveness in order to improve the quality of care and to stay well informed on developments in specialist areas. We examine the resources that are already available to clinicians, strategies for finding and filtering information, and ways of improving dissemination.
Phosphorylation and novel mutations of β-catenin in colon tumors
Authors: Nejat Dalay, Elif Akisik, Sumer Yamaner, Dursun Bugra
Journal: Clinical Cancer Research (2010)

Abstract A significant proportion of colon tumors have defects in the Wnt signaling pathway indicating that wnt signaling plays a major role in carcinogenesis. Mutations and aberrations in this pathway may result in constitutive activation. The β-catenin molecule is a key component of this pathway and in absence of wnt signaling the cellular β—catenin level is kept low through degradation of the protein. Disruption of the β-catenin regulation plays a critical rol ein tumor development. Four critical serine/threonine residues on the protein form the recognition site for the proteasomic degradation complex. Sequential phosphorylation of β —catenin at these sites regulates the degradation rate of the protein. Mutations in this region may block phosphorylation and the mutant protein can escape from destruction. In the present study we investigated β—catenin expression and phosphorylation of the protein at the Ser33, Ser37, Thr 41 and Ser45 sites in tumors and matched normal tissue samples from 77 patients with colon cancer. β—catenin protein expression and and phosphorylation were analyzed by Western Blotting. The phospho-β—catenin expressing SW 480 cell line was used as the normal control. β—catenin protein expression was higher in tumor tissue in % 57.1 of the patients but the difference was not significant. Likewise, no significant difference was observed between phosphorylation levels of the different sites in the tumor and normal tissue. However, phosphorylation of the Ser 33/37/Thr41 and the Ser45 sites were significantly correlated. In the samples displaying differences in phosphorylation between the tumor and the corresponding normal tissue samples the β—catenin gene was analyzed for mutations. We observed a single nucleotide change which has not been described previously in three (5.8 %) patients. This mutation results from a A G transition and leads to the substitution of glutamic acid by lysine. DNA from matched normal colon tissue and peripheral blood of the patients was also analyzed. In none of the patients the mutation was present in the somatic cells. Our data indicate that among the molecular alterations affecting the β—catenin molecule mutations rather than phosphorylation of the protein play a major role. Although not described so far, the mutation presented in this study may constitute a more common variant than some of the previously reported alterations.
Ablative fractional laser assisted photodynamic therapy for the treatment of actinic cheilitis
Authors: N. Dinani, E. Topham, E. Derrick, L. Atkinson
Journal: British Journal of Dermatology (2015)

Journal Article Ablative fractional laser assisted photodynamic therapy for the treatment of actinic cheilitis Get access N. Dinani, N. Dinani Department of Dermatology Worthing Hospital Worthing U.K Search for other works by this author on: Oxford Academic Google Scholar E. Topham, E. Topham Department of Dermatology Brighton General Hospital Brighton U.K Search for other works by this author on: Oxford Academic Google Scholar E. Derrick, E. Derrick Department of Dermatology Brighton General Hospital Brighton U.K Search for other works by this author on: Oxford Academic Google Scholar L. Atkinson L. Atkinson Department of Dermatology Brighton General Hospital Brighton U.K Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 173, Issue 1, 1 July 2015, Page 15, https://doi.org/10.1111/bjd.13911 Published: 01 July 2015
Expression of Fc receptors for IgG during acute and chronic cutaneous inflammation in atopic dermatitis
Authors: R.C.M. Kiekens, T. Thepen, I.C. Bihari, E.F. Knol, J.G.J. Van De Winkel, C.A.F.M. Bruijnzeel-Koomen
Journal: British Journal of Dermatology (2000)

Abstract Atopic dermatitis is an allergic skin disease characterized by elevated total and antigen-specific serum IgE and IgG4 levels. In acute and chronic cutaneous inflammation, large cellular infiltrates including T cells, dendritic cells and macrophages are found, especially in the dermis. These cells play an important part in the regulation of local inflammatory reactions. Receptors binding IgG (FcγR) are involved in dendritic cell and macrophage function. In this study, we examined the in vivo distribution and cellular expression of the three classes of leucocyte FcγR in human skin during acute and chronic cutaneous inflammation in atopic dermatitis. Atopy patch test skin was used as a model for acute inflammation in atopic dermatitis, while chronic lesional skin was used to investigate FcγR expression in chronically inflamed skin. In atopy patch test sites no increase in the number of CD1a+ dendritic cells and a slight increase in macrophages compared with non-lesional skin was observed. Our results showed increased expression of FcγRI (CD64) and FcγRIII (CD16) in acutely inflamed skin as well as in chronically inflamed lesional skin, compared with healthy and non-lesional atopic dermatitis skin. FcγRI was expressed by RFD1+, RFD7+ and CD68+, but not by CD1a+ dermal dendritic cells. RFD1+ dendritic cells and CD68+ macrophages were the main FcγRIII-expressing cells during the acute inflammatory reaction. The significant increase in expression of FcγRIII (CD16) and FcγRI (CD64) probably results from upregulation of the receptors on resident cells. Insight into the presence of FcγR+ cells in human skin during inflammation is important both for our understanding of skin immune reactions and the development of new therapeutic concepts.
Comparative proteomic profiling of tumor progression in fibrosarcoma
Authors: Nilanjana Banerji, Sagarika Kanjilal
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

1840 

Our investigations are directed towards gaining a better understanding of the molecular mechanisms involved in the progression of fibrosarcoma. These highly invasive and difficult to manage mesenchymal tumors afflict ∼11,000 individuals each year in the US and result in a 5-year mortality rate of ∼ 50% due to the development of lung metastases. In order to elucidate changes in protein expression that accompany malignant progression in fibrosacoma, comparative proteomic profiling studies were conducted on matched sets of cell lines from primary tumors and corresponding post-surgical recurrences obtained from a well-characterized feline model of the disease. These cells lines have previously been characterized for in vitro and in vivo growth properties demonstrating malignant progression from primary non-metastatic tumor to metachronous local recurrence with potential for distal metastasis. Using the method of Difference In Gel Electrophoresis (DIGE), Cy3 labeled primary tumor cell proteins & Cy5 labeled proteins obtained from recurrent tumor cells were subjected to iso-electric focusing between the pH range of 4 through 7 followed by SDS PAGE through a 8.5 cm long 4-20% gradient gel. Visualization of labeled proteins on an Amersham Typhoon 8600 Imager and data analysis using the DeCyder Diffrential Analysis Software helped identify several dysregulated proteins in the experimental model which could be confirmed through repetition of the experiment. As shown in the [table][1] below, 26 spots were up or down regulated by > 2.5 fold while 140 other spots were also significantly altered between 1.5-2.5 fold. These leads are being identified by tandem mass spectrometry and validated by real-time PCR and immunohistochemical methods. Overall, the results of our studies show that comparative analysis using both human and feline fibrosarcoma samples has great potential for enhancing our understanding of key molecular components that are altered during the malignant progression of fibrosarcoma, particularly as relates to the development of aggressive biological characteristics. 

![Figure][2]  [1]: #F1
 [2]: pending:yes
Bullying: the need for an interagency response
Authors: R. Chesson
Journal: BMJ (1999)

Papers pp 344 and 348 

Most readers will have experience of bullying either through their own schooldays or those of their children. But bullying may not necessarily be seen either as a social problem or one that has significant implications for health professionals. For many years bullying was the concern of teachers, educationalists, and educational psychologists. Current definitions, however, which highlight abuse, victimisation, and aggression, indicate why it requires the attention of all those who work with children. And recent research, including some in this week's issue, shows psychological effects which should command the attention of doctors.

Over time perceptions have changed of what constitutes bullying, but it may include a range of activities including hitting, pushing, spreading slander, provoking, making threats, extortion, and robbery.1 The commonest types of bullying reported by victims are name calling, followed by being hit, threatened, or having rumours spread about one.2 Interestingly in a British investigation of teachers' views on bullying, undertaken in the mid-1990s, many did not see teasing or social …
Antibiotic resistance patterns of Escherichia coli isolates from different aquatic environmental sources in Leon, Nicaragua
Authors: E. Amaya, D. Reyes, M. Paniagua, S. Calderón, M.-U. Rashid, P. Colque, I. Kühn, R. Möllby, A. Weintraub, C.E. Nord
Journal: Clinical Microbiology and Infection (2012)
Noninvasive diagnostic tools for nonmelanoma skin cancer
Authors: M. Ulrich, E. Stockfleth, J. Roewert-Huber, S. Astner
Journal: British Journal of Dermatology (2007)

Minimally invasive diagnostic tools have received increased attention for diagnosis, screening and management of nonmelanoma skin cancer (NMSC). Several modalities are commercially available, including high frequency ultrasound, optical coherence tomography and confocal microscopy. While systematic clinical analyses are often lacking, recent reports have shown promising results for reflectance confocal microscopy (RCM) for diagnosis of actinic keratoses and basal cell carcinoma.
Localized Prostate Cancer and DNA Ploidy
Authors: Leopold G Koss
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outcomes of Patients With Multiple Cutaneous Squamous Cell Carcinomas
Authors: Danielle E. Levine, Pritesh S. Karia, Chrysalyne D. Schmults
Journal: JAMA Dermatology (2015)

Patients with multiple cutaneous squamous cell carcinomas (CSCCs) pose a management challenge for physicians, but their prognosis is unknown because outcomes have not been compared between patients who form single vs multiple CSCCs.To compare outcomes in patients with 1 vs multiple CSCCs.A 10-year retrospective single-institution cohort study at an academic tertiary care center of patients with dermally invasive (non-in situ) primary CSCC diagnosed from January 1, 2000, through December 31, 2009.Electronic medical records were reviewed to determine the tumor stage (Brigham and Women's Hospital tumor stage) and outcomes (local recurrence [LR], nodal metastases [NM], and death due to CSCC). Outcomes were compared between patients with 1 vs more than 1 CSCC via multivariable competing-risk regression adjusted for other significant cofactors.Of 985 patients with CSCC, 727 had 1 CSCC, 239 had 2 to 9 CSCCs, and 19 had 10 or more CSCCs. Most patients with 10 or more CSCCs were immunosuppressed (15 of 19 [78.9%]). The median follow-up time was 50 months (range, 2-142 months). Patients with more than 1 CSCC had a higher risk of LR (subhazard ratio for 2-9 CSCCs, 1.8; 95% CI, 1.1-4.3; and for ≥10 CSCCs, 3.8; 95% CI, 1.4-10.0) and NM (subhazard ratio for 2-9 CSCCs, 3.0; 95% CI, 1.4-6.5; and for ≥10 CSCCs, 4.2; 95% CI, 1.4-10.4) compared with patients with 1 CSCC, adjusted for Brigham and Women's Hospital tumor stage. The 10-year cumulative incidence of LR and NM was higher in patients with 2 to 9 CSCCs and markedly higher in those with 10 or more CSCCs compared with patients who had 1 CSCC (10-year cumulative incidence for 1 CSCC: LR, 3.0%; 95% CI, 2.0%-4.5%; and NM, 2.3%; 95% CI, 1.5%-3.8%; for 2-9 CSCCs: LR, 6.7%; 95% CI, 4.2%-10.6%; and NM, 5.9%; 95% CI, 3.5%-9.6%; and for ≥10 CSCCs: LR, 36.8%; 95% CI, 19.2%-59.0%; and NM, 26.3%; 95% CI, 11.8%-48.8%).Patients with multiple CSCCs warrant frequent follow-up because they have an elevated risk of LR and NM. In particular, patients with 10 or more CSCCs have markedly elevated risks of recurrence and metastasis.