Metformin Prescription for Insured Adults With Prediabetes From 2010 to 2012
Authors: Rene Rodriguez-Gutierrez, Victor M. Montori
Journal: Annals of Internal Medicine (2015)

Letters15 September 2015Metformin Prescription for Insured Adults With Prediabetes From 2010 to 2012Rene Rodriguez-Gutierrez, MD and Victor M. Montori, MD, MScRene Rodriguez-Gutierrez, MDFrom Mayo Clinic, Rochester, Minnesota.Search for more papers by this author and Victor M. Montori, MD, MScFrom Mayo Clinic, Rochester, Minnesota.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5136 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Moin and colleagues (1) show that the use of metformin in patients with prediabetes is infrequent (3.7%). They suggest that this rate should be higher and call for more research on how to achieve this goal. Although their methods are rigorous, we believe that their article promotes a notion that is highly problematic: that patients with prediabetes benefit from metformin.The case for metformin use for diabetes prevention is based on the results of the DPP (Diabetes Prevention Program) study that found metformin to be effective in delaying the diagnosis of diabetes (2) and on metformin's track ...References1. Moin T, Li J, Duru OK, Ettner S, Turk N, Keckhafer A, et al. Metformin prescription for insured adults with prediabetes from 2010 to 2012: a retrospective cohort study. Ann Intern Med. 2015;162:542-8. [PMID: 25894024] doi:10.7326/M14-1773 LinkGoogle Scholar2. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al; Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393-403. [PMID: 11832527] CrossrefMedlineGoogle Scholar3. Knowler WC, Fowler SE, Hamman RF, Christophi CA, Hoffman HJ, Brenneman AT, et al; Diabetes Prevention Program Research Group.. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet. 2009;374:1677-86. [PMID: 19878986] doi:10.1016/S0140-6736(09)61457-4 CrossrefMedlineGoogle Scholar4. Steptoe A, Hackett RA, Lazzarino AI, Bostock S, La Marca R, Carvalho LA, et al. Disruption of multisystem responses to stress in type 2 diabetes: investigating the dynamics of allostatic load. Proc Natl Acad Sci U S A. 2014;111:15693-8. [PMID: 25331894] doi:10.1073/pnas.1410401111 CrossrefMedlineGoogle Scholar5. Ludwig J, Sanbonmatsu L, Gennetian L, Adam E, Duncan GJ, Katz LF, et al. Neighborhoods, obesity, and diabetes—a randomized social experiment. N Engl J Med. 2011;365:1509-19. [PMID: 22010917] doi:10.1056/NEJMsa1103216 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Rene Rodriguez-Gutierrez, MD; Victor M. Montori, MD, MScAffiliations: From Mayo Clinic, Rochester, Minnesota.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L15-0352. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMetformin Prescription for Insured Adults With Prediabetes From 2010 to 2012 Tannaz Moin , Jinnan Li , O. Kenrik Duru , Susan Ettner , Norman Turk , Abigail Keckhafer , Sam Ho , and Carol M. Mangione Metformin Prescription for Insured Adults With Prediabetes From 2010 to 2012 Tannaz Moin , O. Kenrik Duru , and Carol M. Mangione Metrics 15 September 2015Volume 163, Issue 6Page: 482-483KeywordsDiabetes preventionDisclosureDrugsFoodGlucoseHypoglycemicsSafetySafety studiesStatinsType 2 diabetes ePublished: 15 September 2015 Issue Published: 15 September 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...