tbuckley/cabot-search huggingface dataset:
Abstract 2877: Focal adhesion kinsase (FAK) protein overexpression and gene copy number gain correlate with better outcome in patients with surgically resected NSCLC tumors
Authors: Ximing Tang, Yiran Cai, Carmen Behrens, Heather Lin, J. Jack Lee, Ignacio. I. Wistuba
Journal: Cancer Research (2014)

Abstract Purpose: Cancer cell migration mechanisms are important for invasion and metastasis development. Focal adhesion kinase (FAK) is a critical cancer-related signaling molecule that regulates cell motility and migration. We investigated the effect of tumor FAK protein expression and gene copy number gain in the prognosis of patients with surgically resected non-small cell lung cancer (NSCLC). Material and Methods: We studied FAK protein expression by immunohistochemistry (IHC) in 216 NSCLC stages I-III archival tumors, including 151 adenocarcinomas (ACs) and 65 squamous cell carcinomas (SCCs). In 190 of these tumors (132 ACs and 58 SCCs), we examined FAK gene copy number by fluorescence in situ hybridization (FISH). FAK IHC expression was examined using the H-score, and a score &amp;gt;150 was defined as overexpression. We examined the correlation of FAK abnormalities with tumors' clinic-pathological and molecular features, and with patients' outcome, including recurrence free and overall survivals. Results: FAK cytoplasmic protein expression score (P&amp;lt;0.0001) was significantly higher in AC (143 ± 71) compared to SCC (70 ± 42) histology, and in never smokers than smokers. FAK protein overexpression was more frequently (P=0.0005) detected in stage I (46%) than stage II (22%) and III (23%) tumors. In ACs, FAK protein overexpression was significantly higher (P=0.003) in tumors with EGFR mutation (11/13, 85%) compared with wild-type tumors (40/97, 41%). We found that ≥4 FAK gene copies in ≥20% of malignant cells were detected in 28.8% of ACs and 22.4% of SCCs. We did not find correlation between protein expression and gene copy number. After adjusting for stage and adjuvant therapy, NSCLC and AC patients with FAK expression higher than the median had better overall survival (NSCLC, HR 0.51 [CI 0.29-0.86], P=0.017; AC, HR 0.43 [CI 0.23-0.82], P=0.011) compared with patients without protein overexpression. Also, we found that, after adjusting for stage and adjuvant therapy, FAK gene copy number ≥4 in ≥20% of tumors cells correlated with better overall survival (HR 0.34 [CI 0.16-0.95], P=0.039) in patients with AC histology. Conclusion: FAK protein overexpression and gene copy number gain were frequently detected in NSCLC tumors, and, interestingly, they correlated with better outcome in patients with surgically resected tumors. Citation Format: Ximing Tang, Yiran Cai, Carmen Behrens, Heather Lin, J. Jack Lee, Ignacio. I. Wistuba. Focal adhesion kinsase (FAK) protein overexpression and gene copy number gain correlate with better outcome in patients with surgically resected NSCLC tumors. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2877. doi:10.1158/1538-7445.AM2014-2877
Abstract P170: Ideal Levels of Cardiovascular Health Metrics across Racial and Ethnic Groups in California
Authors: Mohammed Umer A Waris, Nathan D Wong
Journal: Circulation (2014)

Introduction: The American Heart Association (AHA) set a goal to improve the cardiovascular health of the nation by 20% by 2020 and identified cardiovascular disease (CVD) health metrics. We estimated the prevalence of adults at ideal levels for six key CVD health metrics among the racial and ethnic groups in California. Methods: Using data from the California Health Interview Survey (CHIS) 2009 study of adults aged 18 and over, and closely following AHA definitions, we identified prevalence of “poor”, “intermediate”, and “ideal” levels of 6 key CVD health metrics: 1) smoking status, 2) physical activity, 3) BMI, 4) diet score, 5) fasting plasma glucose, and 6) blood pressure among Chinese, Filipino, South Asians, Japanese, Koreans, Vietnamese, Caucasians, Mexican Americans, Other Hispanics, African Americans, and Native Americans/ Alaskan Natives living in California (n=46,693, projected = 26.6 mil). The seventh key AHA metric, cholesterol, was not available in our sample. Results: Among all racial/ ethnic groups, physical activity, BMI, and diet score were the metrics at poorest levels. Wide variability in ideal levels for the six key CVD health metrics is seen across all racial/ ethnic groups (table). The CVD health metrics were most consistently poor among American Indians/ Alaskan Natives but were also at low levels for specific Asian, Hispanic, and African American groups. Less than 1% of all California adults had ideal measures for all six CVD Health metrics. Conclusions: Our study shows wide variability between Asian and other racial/ ethnic groups in key CVD health metrics in California. Larger scale national surveys representing all key US racial and ethnic groups are needed to validate these findings and to document the gaps needed to be addressed for improving CVD health. These findings provide opportunities for targeted health outreach to those racial/ ethnic groups most at risk and addressing metrics at poorest attainment. Table. Proportion (%) at Ideal Levels of CVD Health Metrics, by Race and Ethnicity
Abstract 14060: Syndesomes: Novel Therapeutics for Chronic Ulcers and Peripheral Ischemia
Authors: Subhamoy Das, Gunjan Singh, Anthony J Monteforte, Matthew E Martinez, Andrew K Dunn, Aaron B Baker
Journal: Circulation (2014)

Introduction: Peripheral arterial disease patients often suffer from ischemia and chronic non-healing ulcers. Our previous studies showed a dramatic reduction in syndecan-4 protein in the muscle of obese diabetic mice. Reduction of syndecan-4 (co-receptor for FGF-2) suggests a resistance to FGF-2 stimulation in diseased state. Here, we demonstrate a novel strategy to address the problem by delivering the missing syndecan-4 and FGF-2 in a liposomal formulation. Hypothesis: Delivering the missing syndecan-4 would improve the therapeutic potential of FGF-2 for treating both ischemia and wounds in a diseased state. Methods: Treatments were microencapsulated in a 4% alginate as microspheres or discs. An ob/ob mouse model with 10 weeks of high fat diet was used to recapitulate the diseased condition. Ischemia was created in mice through femoral artery ligation and alginate microspheres were placed at the incision site. Blood perfusion in the feet was monitored using laser speckle contrast imaging. Excisional wo...
Prognosis of follicular lymphoma: a predictive model based on a retrospective analysis of 987 cases
Authors: Massimo Federico, Umberto Vitolo, Pier Luigi Zinzani, Teodoro Chisesi, Vera Clò, Giampiero Bellesi, Massimo Magagnoli, Marina Liberati, Carola Boccomini, Pasquale Niscola, Vincenzo Pavone, Antonio Cuneo, Gino Santini, Maura Brugiatelli, Luca Baldini, Luigi Rigacci, Luigi Resegotti
Journal: Blood (2000)
Heparan Sulfate Proteoglycan Expression Is Induced During Early Erythroid Differentiation of Multipotent Hematopoietic Stem Cells
Authors: Zofia Drzeniek, Georg Stöcker, Barbara Siebertz, Ursula Just, Timm Schroeder, Wolfram Ostertag, Hans-Dieter Haubeck
Journal: Blood (1999)
The results of drug resistance survey of MDR-strains on second line drugs obtains in national reference laboratory – “M.Nasta” Institute, Bucharest
Authors: Olga Moldovan, Daniela Homorodean, Elmira Ibraim, Monica Bendorf, Cristian Popa
Journal: European Respiratory Journal (2011)

Objectives:  To evaluate resistance of MDR strains to the second line drugs – Kanamycin and Ofloxacine and XDR-TB among patients MDR-TB.   Materials and methods:  In 1 octombrie 2009-31 ianuarie 2010 was included in this study 419 patients 53 new and 366 previously treated cases which had positive cultures with MDR strains. The testing of this MDR strains was performed by indirect method of proportion to second line drugs for critical proportion 1%.   Results:  1.For new cases results showed the confirmation of MDR strains 8,83%; resistant to INH+RMP+KM 2,63%; resistant to INH+RMP+OFX 0,24.% and XDR strains 0,95%.  2. For previously treated cases results showed the confirmation of MDR strains 49,64%; resistant to INH+RMP+KM 22,20%; resistant to INH+RMP+OFX 7,16% and XDR strains 8,35%.   Conclusions:  1.The high percentage of MDR strains of previously treated cases-49,64% is due to large number of patients provide from our Excellence Center of MDR TB.  2.The percentage of XDR strains from MDR strains is 9,31%.
Evaluation of preoperative and postoperative exercise capacity by using six-minute walk test
Authors: Rengin Demir, Ali Can Hatemi, Serdar Kucukoglu, Zerrin Yigit, Hulya Nilgun Gurses
Journal: European Respiratory Journal (2012)

The aim of this study was to evaluate preoperative and postoperative exercise capacity of the patients by using six-minute walk test (6MWT) in patients electively undergone coronary artery bypass surgery. Twenty-nine patients whose mean age was 60.89 enrolled to the study. 6MWT was done at two time set (before operation and at discharge from hospital). Heart rate, blood pressure and oxygen saturation levels was noted, level of dyspnea and fatigue determined by Borg scale before and after test and walking distances recorded after six minutes. Walking distance was 349 meters (66% of predicted values) before operation and 284 meters (54% of predicted values) after operation. Decrease of walking distance after operation was statistically significant (among measured and predicted values, p
Abstract 13759: Nitrogen Rich Plasma Activated Coatings for Enhancement of Endovascular Stent Biocompatibility
Authors: Young Yu, Alexey Kondyurin, Steven G Wise, David S Celermajer, Marcela M Bilek, Martin K Ng
Journal: Circulation (2014)

Introduction: Stent thrombosis and restenosis are clinical manifestations of suboptimal biocompatibility. A novel coating platform that simultaneously promotes endothelialization and inhibits thrombosis may circumvent deficiencies in stent biocompatibility.

Objective: A plasma activated coating (PAC) for surface modification of metallic alloys using plasma enhanced chemical vapor deposition was developed. To enhance biocompatibility, nitrogen gas doping during deposition was deployed to produce nitrogenized PAC variants.

Methods and Results: PAC with nitrogen concentrations of 3% (PAC3), 14% (PAC14) and 27% (PAC27) was created. PAC27 was the most hydrophilic (water contact angle 55.2±1.7°) and enriched with polar surface chemical groups. Thrombogenicity studies revealed an inverse relationship between nitrogen content and thrombus formation in static blood assays (316L steel (SS): 210.4±16.8, PAC3: 74.4±43.3, PAC14: 58.5±38.6, PAC27: 4.5 ± 3.28 mg, P<0.05, (Fig 1A and B)) and in Chandler loop assays (SS: 36.3±3.5, PAC3: 33.5±1.9, PAC14: 15.4±3.4, PAC27: 5.3±3.4 mg, P<0.05). Platelet activation in the Chandler loop measured by P-selectin levels was lower for PAC27 than SS, 12.3±1.4 vs. 17.4±1.7 ng/ml, P<0.05). High nitrogen PAC also enhanced human coronary artery endothelial cell (HCAEC) adhesion (38.7±4.7% (SS), 45.2±6.8% (PAC3), 53.6±6.6% (PAC14), 70.4±2.7% (PAC27) attachment, p<0.05) (Fig 1C). Furthermore, HCAEC proliferation on PAC27 was 23.9±1.3% higher than SS, p<0.001. Robust adhesion of PAC27 coated on SS stents was seen on scanning electron microscope.

Conclusions: A nitrogen rich PAC has been developed for surface modification of stent related metal alloys. PAC deposition strikingly reduces thrombogenicity and enhanced HCAEC adhesion & proliferation in a nitrogen dependent manner. This high scalable technology, compatible with contemporary stent platforms, has potential to enhance the biocompatibility of endovascular stents.

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Endothelial Dysfunction Induced by Post-Prandial Lipemia
Authors: Gjertrud Aunet Tyldum, Inga Ekeberg Schjerve, Arnt Erik Tjønna, Idar Kirkeby-Garstad, Tomas O. Stølen, Russell S. Richardson, Ulrik Wisløff
Journal: Journal of the American College of Cardiology (2009)
LSC 2011 Abstract: P2Y2 receptor regulates VCAM-1 membrane and soluble forms and eosinophil accumulation during lung inflammation
Authors: G. Vanderstocken, B. Bondue, M. Horckmans, L. Di Pietrantonio, B. Robaye, J.M. Boeynaems, D. Communi
Journal: European Respiratory Journal (2011)

ATP has been defined as a key mediator of asthma. In this study, we evaluated lung inflammation in mice deficient for the P2Y2 purinergic receptor. We observed that eosinophil accumulation, a distinctive feature of lung allergic inflammation, was defective in OVA-treated P2Y2-deficient mice compared with OVA-treated wild type animals. Interestingly, the upregulation of VCAM-1 was lower on lung endothelial cells of OVA-treated P2Y2-/- mice compared with OVA-treated wild type animals. Adhesion assays demonstrated that the action of UTP on leukocyte adhesion through the regulation of endothelial VCAM-1 was abolished in P2Y2-deficient lung endothelial cells. Additionally, the level of soluble VCAM-1, reported as an inducer of eosinophil chemotaxis, was strongly reduced in the bronchoalveolar lavage fluid (BALF) of P2Y2-deficient mice. In contrast, we observed comparable infiltration of macrophages and neutrophils in the BALF of LPS-aerosolized P2Y2+/+ and P2Y2-/- mice. This difference could be related to the much lower level of ATP in the BALF of LPS-treated mice compared with OVA-treated mice.  Our data define P2Y2 as a regulator of membrane and soluble forms of VCAM-1 and eosinophil accumulation during lung inflammation.
Rumours suggest Mbeki's spokesman died of AIDS related disease
Authors: Pat Sidley
Journal: BMJ (2000)

The spokesman of President Thabo Mbeki, Parks Mankahlana, died last week aged 36, rekindling the furious debate in South Africa about HIV and AIDS. Several sources close to him said that he died of an AIDS related disease—but his widow angrily denied it, claiming that he died of heart failure following anaemia.

The media differed on how to treat the issue. One large group known for its close relationship to President Mbeki kept to the family line; others reported the rumours and called for openness on …
Tau gene mutation in familial progressive subcortical gliosis
Authors: M. Goedert, M.G. Spillantini, R.A. Crowther, S.G. Chen, P. Parchi, M. Tabaton, D.J. Lanska, W.R. Markesbery, K.C. Wilhelmsen, D.W. Dickson, R.B. Petersen, P. Gambetti
Journal: Nature Medicine (1999)
Unexpected extradermatological findings in 31 patients with xeroderma pigmentosum type C
Authors: S. Hadj-Rabia, D. Oriot, N. Soufir, H. Dufresne, E. Bourrat, S. Mallet, N. Poulhalon, E. Ezzedine, B. Grandchamp, A. Taïeb, B. Catteau, A. Sarasin, C. Bodemer
Journal: British Journal of Dermatology (2012)

Xeroderma pigmentosum type C (XP-C) is a rare, autosomal, recessive condition characterized by the association of various clinical manifestations mostly involving the skin and eyes.To evaluate the clinical manifestations in a homogeneous, genetically characterized cohort of patients with XP-C.All patients with XP-C, which was confirmed genetically or by unscheduled DNA synthesis, from the registry of our department and from the French association of patients 'Les Enfants de la Lune' were contacted. During a planned consultation, clinical information was collected using a standardized case-record form.In total, 31 patients were seen. The mean age at diagnosis was 2.95 years; skin symptoms started at a mean age of 1.49 years. Among the patients, 52% had relatively short stature, with a height-for-weight z-score below -1 SD; 62% showed pyramidal syndrome and 45% had photophobia and/or conjunctivitis. Four patients had several pyogenic granulomas. Twenty-four patients (77%) had skin cancer. The mean age of onset of the first skin cancer was 4.76 years (range 2-14.5 years). Basal-cell carcinoma was the most frequent cancer. Melanomas were rare and mostly desmoplastic. Multinodular thyroid was the most frequent internal tumour.Our data highlight several new aspects of XP-C. Patients with XP-C are at risk of developing pyogenic granulomas, desmoplastic melanomas and multinodular thyroid. Involvement of the central nervous system is frequent, but its mechanism remains unclear. The relatively short stature of the patients needs further investigation in order to be explained. XP-C is not only a cancer-prone disorder but is also a polysystemic disorder.
UN Conference Endorses Battle Plan for HIV/AIDS
Authors: J Stephenson
Journal: JAMA (2001)

UNITED NATIONS—Two decades after the first reports of the emergence of HIV/AIDS, delegates to the United Nations (UN) General Assembly approved a sweeping plan to battle the pandemic that has already claimed the lives of 22 million people worldwide. Some 3000 government officials, nongovernmental organizations, drug company executives, and others gathered at the UN to set a global agenda for tackling the disease. They also hoped catalyze the creation of a global fund to provide resources for care and medical treatment for those already infected and prevention programs to prevent further spread of the virus. UN SecretaryGeneral Kofi Annan urged the world— including governments, social agencies, philanthropies, and businesses—to spend $7 billion to $10 billion a year to respond to the pandemic. After a contentious debate involving cultural and political sensitivities, the 189-member body agreed to a 103point “declaration of commitment” that sets goals aimed at controlling the global health catastrophe as well as timetables for achieving such goals. “What is important is that, after today, we shall have a document setting out a clear battle plan for the war against HIV/ AIDS, with clear goals and a clear timeline,” said Annan, who spearheaded the special session—the first convened to take action on a public health issue.
A memorable experience: The qat party
Authors: D N Baron
Journal: BMJ (1999)

About 15 years ago I went on a medical academic visit to the Yemeni capital, Sana'a. Everyone was very hospitable, and one afternoon a Yemeni colleague invited me to join him socially to chew qat [khat] This grows as a small tree ( Catha edulis) that flourishes around the Red Sea, with leaves like privet. These leaves contain cathinone (α-aminopropiophenone, related to amphetamine) as the most powerful substance, which breaks down within days to the weaker cathine (norpseudoephedrine), and related compounds. So they act as uppers; a near equivalent Western upper is “speed”. …
Abstract 14976: Impact of the Duration of Dual Antiplatelet Therapy in Patients with Peripheral Arterial Occlusive Disease After Percutaneous Transluminal Angioplasty on Clinical Outcomes
Authors: Sungsoo Cho, Young-Guk Ko, Dong-Ho Shin, Jung-Sun Kim, Byeong-Keuk Kim, Donghoon Choi, Myung-Ki Hong, Yangsoo Jang
Journal: Circulation (2014)

Introduction: Limited data from clinical trials investigating dual antiplatelet therapy (DAPT) in patients with peripheral arterial occlusive disease (PAOD), suggested its potential for a reduction in cardiovascular events. However, the optimal duration of DAPT in patients with symptomatic PAOD after percutaneous transluminal angioplasty (PTA) has not been clearly established. The aim of this study was to determine the optimal duration of DAPT in patients with symptomatic PAOD after PTA. Hypothesis: Longer duration of DAPT is associated with better clinical outcomes in patients with symptomatic PAOD after PTA. Methods: From May 2011 to August 2012, 249 patients with 264 lesions treated with PTA were divided into two groups based on the duration of DAPT [aspirin plus clopidogrel, &lt; 6-month DAPT (n= 120) vs. ≥ 6-month DAPT (n = 129)]. Propensity score-matching analysis was used to adjust for baseline characteristics between two groups. Results: The median follow-up duration was 22.0 ± 8.2 months. In Cox proportional hazard analysis, ≥ 6-month DAPT group was found to be associated with lower rates of MACE (myocardial infarction, stroke, death, and target lesion revascularization; hazard ration [HR]: 2.22; 95% confidence interval [CI]: 1.13-4.35, p = 0.021), and rehospitalization (unstable angina, transient ischemic attack, amputation, and other lesions PTA; HR: 2.29; 95% CI: 1.04-5.01, p = 0.039). Nevertheless, there was no significant association between duration of DAPT and bleeding. Conclusions: DAPT longer than 6 months was associated with lower rates of MACE and rehospitalization in patients with symptomatic PAOD after PTA.
An Elementary Text Book of General Microbology.
Authors: Ward Giltner
Journal: JAMA (1928)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HIV positive applicant wins case against South African airline
Authors: Pat Sidley
Journal: BMJ (2000)

South Africa's constitutional court has ruled in favour of a prospective employee of South African Airways who was refused employment on the grounds of his positive result for an HIV test.

The court ordered South African Airways to employ the applicant, who had applied to be a cabin attendant. Importantly, the court focused on the rights of a significant minority in the country—where some four million people are HIV positive—and drawn attention explicitly to the fact …
Abstract 204: The Adoption of Multiple Best Practices to Improve Out-of-Hospital Cardiac Arrest in Salt Lake City, Utah
Authors: Scott Youngquist, Chris Burk, Daniel Reilly, Clair Baldwin
Journal: Circulation (2014)

BACKGROUND: Survival from out-of-hospital cardiac arrest has remained unchanged over the last 30 years in the United States, with the exception of survival in a few high-performance EMS systems. We hypothesized that the implementation of several best practices from such EMS systems would result in improved survival in our community. METHODS: In September 2011, the Salt Lake City Fire Department (SLCFD) implemented a 2010 AHA-based protocol for reducing hands-off time and improving CPR quality, including use of CPR-filtering technology to reduce pauses for rhythm analysis, real-time CPR feedback, intra-arrest chilled saline, team resuscitation based on a pit crew model, impedance threshold device CPR, and post-incident audit and feedback of all cardiac arrests by the medical director. Outcomes were collected from each receiving hospital, and Cerebral Performance Category (CPC) was used to estimate neurologic outcome. A CPC 1 or 2 was considered neurologically-intact. We evaluated performance prior to and f...