tbuckley/cabot-search huggingface dataset:
Decoy Receptor 3 Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome
Authors: Cheng-Yu Chen, Kuang-Yao Yang, Mei-Yu Chen, Hsuan-Yu Chen, Ming-Tzer Lin, Yu-Chin Lee, Reury-Perng Perng, Shie-Liang Hsieh, Pan-Chyr Yang, Teh-Ying Chou
Journal: American Journal of Respiratory and Critical Care Medicine (2009)

Rationale: Acute respiratory distress syndrome (ARDS), a serious inflammatory reaction to acute lung injury, is associated with high mortality rates. Decoy receptor (DcR) 3 is a soluble protein with immunomodulatory effects. Biomarkers that reliably predict outcomes in ARDS are not currently available.Objectives: Comparing DcR3 with the Acute Physiology and Chronic Health Evaluation (APACHE) II scores and three other plasma markers to explore the association of DcR3 and the clinical outcome in ARDS.Methods: Eighty-eight patients with ARDS were studied. Baseline APACHE II scores and clinical data were recorded. Plasma levels of DcR3, soluble triggering receptor expressed on myeloid cells (sTREM)-1, tumor necrosis factor (TNF)-α, and IL-6 were measured on Day 1 and later time points, and correlated with the survival status on Day 28 after the onset of ARDS. For validation, 59 patients with ARDS from another medical center were studied.Measurements and Main Results: Among the biomarkers evaluated, only DcR3 discriminated the survivors and nonsurvivors at all time points in the first week of ARDS. DcR3 independently associated with and best predicted the 28-day mortality of patients with ARDS. Plasma DcR3 levels most correlated to multiple-organ dysfunction and ventilator dependence. Compared with survivors, the nonsurvivors had higher DcR3 levels regardless of the APACHE II scores. Kaplan-Meier survival analysis showed higher mortality in patients with ARDS with higher DcR3 levels. The outcome prediction of patients with ARDS by plasma DcR3 levels was recapitulated by the validation cohort.Conclusions: High plasma DcR3 levels correlate with development of multiple-organ dysfunction and independently predict the 28-day mortality in patients with ARDS.
ASSOCIATION OF A POLYMORPHISM IN SLCO1B1 WITH STATIN-INDUCED MYALGIAS, MYOSITIS AND MYOPATHY: AN ELECTRONIC MEDICAL RECORD BASED PHARMACOGENETIC STUDY
Authors: Adnan A. Khan, Keyue Ding, Shameer Khader, Iftikhar J. Kullo
Journal: Journal of the American College of Cardiology (2011)
THE RELEVANCE OF TROPONIN AND NATRIURETIC PEPTIDES AS PROGNOSTIC MARKERS IN PATIENTS WITH ACUTE PULMONARY EDEMA AND PRESERVED LEFT VENTRICULAR SYSTOLIC FUNCTION: A REPORT FROM CIAST-HF STUDY
Authors: Eduardo Perna, Roberto Valle, Juan P. Cimbaro Canella, Giusepe Di Tano, Stella Macin, Loredano Milani, Maria L. Coronel, Massimo Milli, Nadia Aspromonte
Journal: Journal of the American College of Cardiology (2011)
Stroke As a Late Treatment Effect of Hodgkin's Disease
Authors: Lucille Désirée Dorresteijn, Fiona Anne Stewart, Willem Boogerd
Journal: Journal of Clinical Oncology (2006)

THE EDITOR: Bowers et al 1 are commended for their large cohort study on the risk of stroke in long-term survivors of Hodgkin's disease.This is the first study showing an absolute increased risk of stroke in these young patients, who were not prone to atherosclerotic diseases because of their age.After a median interval of 17.5 years, these patients have an increased relative risk of stroke of 4.3 in comparison with a sibling control group.This observed increased risk is in agreement with the elevated risk of stroke we found in patients irradiated for head and neck tumors. 2 However, the interval before the onset of stroke is longer in the Hodgkin's population: 17.5 years versus 10.9 years in the head and neck population.This could possibly be explained by differences in underlying pathogenetic mechanisms.In atherosclerotic-naive patients, like in the Hodgkin's population, irradiation on the neck seems to induce atherosclerotic-like lesions of the carotid artery.In contrast, in the population of older patients with head and neck cancer, radiation therapy (RT) accelerates pre-existing atherosclerotic disease.Both processes can eventually cause stenosis of the carotid artery 3 and thromboembolisms leading to stroke, but the timing of this depends on whether the atherosclerotic process was already initiated before irradiation.In addition, increased thickness of the carotid vascular wall in the older head and neck cancer patients might sooner induce flow disturbances and shear stress, further accelerating the atherosclerotic process.The relatively low-dose of RT used in the treatment of Hodgkin's disease (median dose, 40 Gy) compared with the dose used for head and neck cancer (60 to 70 Gy) might also contribute to slower progression of the lesions.A limitation of the Bowers study is that stroke was not confirmed by a computed tomography scan.Therefore, the contribution of other causes of cerebrovascular disease, like intracranial hemorrhage, cannot be established, nor can the origin of stroke be ascertained.Hodgkin's disease patients who receive mantle irradiation are also at risk for cardiac disease, such as valvular diseases, 4 which can also result in stroke in these patients.We agree with the authors that patients who receive irradiation on the neck should be monitored, especially those patients who have an estimated long survival.However, the suggestion of interviewing patients to establish the occurrence of cerebrovascular disease is, in our view, not the most appropriate solution, because the damage has already been done by then.We suggest duplex screening of the carotid arteries as a crucial part of follow-up to identify damage before it is associated with clinical symptoms.The next step is to investigate possible intervention strategies in order to diminish these debilitating late complications in long-term survivors of cancer.
CIRRHOSIS OF THE LIVER IN "DONOR" DOGS FED A HIGH FAT DIET AND SUBJECTED TO REPEATED BLEEDINGS
Authors: Russell L. Holman
Journal: The Journal of Experimental Medicine (1945)

1. In 13 dogs used repeatedly as donors for plasmapheresis and plasma injection experiments and fed a kennel diet that for a period of over a year consisted chiefly of bones with much adherent fat, cirrhosis of the liver occurred in 10. Marked fatty change without definite fibrosis occurred in 2 of the dogs. 2. In control dogs fed the same kennel diet during the same period but not subjected to repeated bleedings, no instance of cirrhosis was observed. 3. In previous plasmapheresis and plasma injection experiments "donor dogs" subjected to similar bleedings over comparable periods but maintained on a different kennel diet did not develop cirrhosis. 4. This series of events suggests that in dogs maintained on a relatively high fat diet repeated bleedings predispose them to cirrhosis of the liver. No data are available to decide the more fundamental question: Do the repeated bleedings remove something (other than hemoglobin) necessary for continued integrity of the liver, or is the cirrhosis the result of relative anoxia or increased lipemia occasioned by the repeated bleedings or perhaps of both combined?
Avoiding therapeutic pitfalls: The rational use of specifically targeted agents against hepatitis C infection
Authors: Barbara H. McGovern, Barham K. Abu Dayyeh, Raymond T. Chung
Journal: Hepatology (2008)

The development of specifically targeted antiviral agents against hepatitis C is a major therapeutic advance that promises to markedly improve treatment response rates in patients with chronic infection. However, rapid emergence of drug resistance has already been described, the consequences of which are not yet understood. Although there are important differences between hepatitis C (HCV) and human immunodeficiency virus (HIV) infection, the judicious use of candidate agents against HCV should be guided by principles that have been established in the HIV therapeutic arena. In this review, we attempt to draw useful parallels between the development of antiretroviral therapy for HIV and preliminary data on antiviral agents for hepatitis C virus infection. Applying concepts learned in HIV therapeutics will hopefully lead to a prudent and cautious path in HCV treatment paradigms, particularly with respect to drug resistance.
Meta-analysis of psychological treatments for posttraumatic stress disorder in adult survivors of childhood abuse
Authors: Thomas Ehring, Renate Welboren, Nexhmedin Morina, Jelte M. Wicherts, Janina Freitag, Paul M.G. Emmelkamp
Journal: Clinical Psychology Review (2014)

Posttraumatic stress disorder (PTSD) is highly prevalent in adult survivors of childhood sexual and/or physical abuse. However, intervention studies focusing on this group of patients are underrepresented in earlier meta-analyses on the efficacy of PTSD treatments. The current meta-analysis exclusively focused on studies evaluating the efficacy of psychological interventions for PTSD in adult survivors of childhood abuse. Sixteen randomized controlled trials meeting inclusion criteria could be identified that were subdivided into trauma-focused cognitive behavior therapy (CBT), non-trauma-focused CBT, eye movement desensitization and reprocessing, and other treatments (interpersonal, emotion-focused). Results showed that psychological interventions are efficacious for PTSD in adult survivors of childhood abuse, with an aggregated uncontrolled effect size of g = 1.24 (pre- vs. post-treatment), and aggregated controlled effect sizes of g = 0.72 (post-treatment, comparison to waitlist control conditions) and g = 0.50 (post-treatment, comparison with TAU/placebo control conditions), respectively. Effect sizes remained stable at follow-up. As the heterogeneity between studies was large, we examined the influence of two a priori specified moderator variables on treatment efficacy. Results showed that trauma-focused treatments were more efficacious than non-trauma-focused interventions, and that treatments including individual sessions yielded larger effect sizes than pure group treatments. As a whole, the findings are in line with earlier meta-analyses showing that the best effects can be achieved with individual trauma-focused treatments.
Chronic hemodynamic and antifibrotic effects of a specific angiotensin II receptor antagonist (losartan) in bile duct ligated (BDL) rats and in portal vein ligated (PVL) rats
Authors: V. Croquet, F. Moal, F. Oberti, J. Wang, J. Roux, N. Veal, E. Vuillemin, Y. Gallois, O. Douay, P. Cales
Journal: Journal of Hepatology (2001)
Does initial management affect the rate of repetition of deliberate self harm? Cohort study
Authors: M J Crawford, S Wessely
Journal: BMJ (1998)

In the year following presentation to hospital after deliberate self harm, up to 25% of people repeat the act.1 A range of sociodemographic and psychological factors has been shown to predict the likelihood of repetition. 2 3 Factors related to the management of patients may also be important. Observational studies have suggested that some people who receive a psychiatric assessment as part of their initial management may have lower rates of repetition of self harm.4 We examined the effect of other aspects of management on rates of repetition among a cohort of patients presenting to medical services after deliberate self harm.

All incidents of deliberate self harm among patients registered with 16 randomly selected general practices in the inner city area of Southwark, south London, were monitored over 18 months. We recorded details of initial psychosocial …
LFA-1, and not Mac-1, is crucial for the development of hyperreactivity in a murine model of nonallergic asthma.
Authors: P G Bloemen, T L Buckley, M C van den Tweel, P A Henricks, F A Redegeld, A S Koster, F P Nijkamp
Journal: American Journal of Respiratory and Critical Care Medicine (1996)

In this study, we investigated the importance of the beta 2-integrins for the development of tracheal hyperreactivity in a murine model for nonallergic asthma. The response was induced by skin sensitization with dinitrofluorobenzene (DNFB) followed by an intranasal challenge with the same hapten. Twenty-four hours after the challenge, tracheal hyperreactivity, a decrease in T cells in the blood, and increased neutrophil numbers in bronchoalveolar lavage fluid (BALF) and blood were observed. Monoclonal antibodies (mAbs) directed against the alpha-chains of LFA-1 (FD441.8) and Mac-1 (M1/70) were injected intravenously 2 h before and 2 h after the challenge. Treatment with anti-LFA-1 mAb totally inhibited the development of tracheal hyperreactivity measured 24 h after the challenge, whereas anti-Mac-1 mAb had only a partial effect on this response. The decrease in T cells in the blood, which was also evident 24 h after the challenge, was totally inhibited by treatment with anti-LFA-1, whereas anti-Mac-1 had little effect. The increase in the number of neutrophils in BALF at this time point was completely inhibited by both anti-LFA-1 and anti-Mac-1. In summary, evidence presented in this report highlights the possible importance of the adhesion molecule LFA-1 in the development of tracheal hyperreactivity. Our results suggest that LFA-1 present on T cells may play an integral role in this response.
Incidence of IDDM in Children Living in Puerto Rico
Authors: Teresa E Frazer de Llado, Lilliam Gonzalez de Pijem, Barbara Hawk
Journal: Diabetes Care (1998)

OBJECTIVE To determine incidence, geographic distribution, and seasonal variation of IDDM in children 0–14 years of age living in Puerto Rico. Because these data have been collected through the infrastructure of the World Health Organization's DiaMond project, these results are direcdy comparable widi incidence data from other populations worldwide involved in this study. RESEARCH DESIGN AND METHODS Beginning in 1990, new cases of IDDM were registered retrospectively from 1985 and prospectively to 1994 by review of medical records from island hospitals. Included in the hospital registry are 1,527 cases of IDDM. Validation of the primary source was by three secondary lists of cases obtained through diabetic camps, surveys of schools, and a government registry. Log linear modeling (capture-recapture) was used to correct incidence. RESULTS Mean incidence of IDDM from 1985–1994 was 18.0 cases/100,000 children per year (95% CI 17.6–18.3). There was a slight female rather than male predominance: 51% of the cases were girls, and 49% were boys. Although Puerto Rico has marked variation in rainfall, altitude, and geneticmarkers, no significant differences are found in the incidence rates of different areas or seasons of the island. CONCLUSIONS This registry of Puerto Rican children is the largest IDDM registry of minority children in the U.S. The results of this study indicate that the annual incidence of IDDM of children living in Puerto Rico is higher than the incidence of other multiracial ethnic groups living in the U.S.
Sublingual Immunotherapy with a Once-daily 5-grass Pollen Tablet: Efficacy Assessment in an Allergen Challenge Chamber (ACC)
Authors: P. Devillier, A. Montagut, M. Michel, S. Galvain, M. Le Gall, P. Zieglmayer, Z. René, P. Lemell, F. Horak
Journal: Journal of Allergy and Clinical Immunology (2009)
Which HOME for atopic dermatitis?
Authors: A. Taïeb
Journal: British Journal of Dermatology (2014)

Journal Article Which HOME for atopic dermatitis? Get access A. Taïeb A. Taïeb Service de Dermatologie et Dermatologie Pédiatrique CHU de Bordeaux Bordeaux France Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 171, Issue 6, 1 December 2014, Pages 1286–1287, https://doi.org/10.1111/bjd.13448 Published: 01 December 2014
LKM1 autoantibodies in chronic hepatitis C infection: A case of molecular mimicry?
Authors: Gabriel Marceau, Pascal Lapierre, Kathie Béland, Hugo Soudeyns, Fernando Alvarez
Journal: Hepatology (2005)

Abstract Anti-liver-kidney microsome type 1 (LKM1) autoantibodies directed against the cytochrome P450 2D6 (CYP2D6) are considered specific markers of type 2 autoimmune hepatitis, but are also found in 5% of sera from patients chronically infected by hepatitis C virus (HCV). Molecular mimicry between HCV proteins and CYP2D6 has been proposed to explain the emergence of these autoantibodies. Anti-LKM1 autoantibodies from hepatitis C–infected patients were affinity-purified against immobilized CYP2D6 protein and used to screen a phage display library. CYP2D6 conformational epitopes were identified using phage display analysis and the identification of statistically significant pairs (SSPs). Cross-reactivity between CYP2D6 and HCV protein candidates was tested by immunoprecipitation. Nineteen different clones were isolated, and their sequencing resulted in the mapping of a conformational epitope to the region of amino acids 254-288 of CYP2D6. Candidate HCV proteins for molecular mimicry included: core, E2, NS3 and NS5a. Affinity-purified autoantibodies from HCV+/LKM1+ patients immunoprecipitated either NS3, NS5a, or both, and these reactivities were specifically inhibited by immobilized CYP2D6. In conclusion , HCV+/LKM1+ sera recognize a specific conformational epitope on CYP2D6 between amino acids 254 to 288, the region that contains the major linear epitope in type 2 autoimmune hepatitis patients. Cross-reactivity due to molecular mimicry at the B-cell level was shown between the CYP2D6 and the HCV NS3 and NS5a proteins and could explain the presence of anti-LKM1 in patients chronically infected with HCV. Further investigation of the role played by this molecular mimicry in HCV-infected patients may lead to more specific strategies for diagnosis and treatment. (Hepatology 2005.)
Effectiveness of an Antioxidant in Preventing Restenosis After Percutaneous Transluminal Coronary Angioplasty: The Probucol Angioplasty Restenosis Trial
Authors: Hisashi Yokoi, Hiroyuki Daida, Yoichi Kuwabara, Hideo Nishikawa, Fumimaro Takatsu, Hitoshi Tomihara, Yasuro Nakata, Yasunori Kutsumi, Shigeru Ohshima, Shinichiro Nishiyama, Akira Seki, Kenichi Kato, Shigeyuki Nishimura, Tatsuji Kanoh, Hiroshi Yamaguchi
Journal: Journal of the American College of Cardiology (1997)
ROUTINE INVASIVE VERSUS SELECTIVE INVASIVE STRATEGY AND LONG-TERM OUTCOMES IN PATIENTS WITH REDUCED RENAL FUNCTION PRESENTING WITH NON-ST SEGMENT ELEVATION ACUTE CORONARY SYNDROME
Authors: Pier Woudstra, Peter Damman, Tim Clayton, Lars Wallentin, Bo Lagerqvist, Keith Fox, Alexander Hirsch, Eva Swahn, Stuart Pocock, Jan Tijssen, Robbert de Winter
Journal: Journal of the American College of Cardiology (2012)
Importance of open lung biopsy in the diagnosis of invasive pulmonary aspergillosis in patients with hematologic malignancies
Authors: Kihyun Kim, Mark H. Lee, Jingook Kim, Kyung Soo Lee, Sung Min Kim, Man Pyo Jung, Joungho Han, Ki Woong Sung, Won Seog Kim, Chul Won Jung, Sung Soo Yoon, Young‐Hyuck Im, Won Ki Kang, Keunchil Park, Chan Hyung Park
Journal: American Journal of Hematology (2002)

Abstract Invasive pulmonary aspergillosis is a serious infectious complication in immunocompromised patients. Recent reports indicate its favorable clinical outcomes by early diagnosis with chest computed tomography scan. We retrospectively analyzed our experiences with histopathological evaluation by open lung biopsy in 31 patients (32 cases) with hematologic malignancies, suspected of having invasive pulmonary aspergillosis clinically and radiologically. Although the initial computed tomography findings of all cases were highly indicative of invasive pulmonary aspergillosis by demonstrating nodules or masses with a halo sign (16 cases), segmental area of consolidation with ground‐glass attenuation (7 cases), both nodules or masses with a halo sign and segmental area of consolidation with ground‐glass attenuation (7 cases) and poorly defined centrilobular nodules (2 cases), we could histopathologically confirm invasive fungal infections only in 17 cases (53.1%) by open lung biopsy. There were 13 cases of invasive pulmonary aspergillosis, two cases of aspergilloma, and two cases of mucormycosis. No fungal hyphae were found in the other 15 cases: organizing pneumonia in seven cases, pulmonary hemorrhage in three cases, brochiolitis obliterans with organizing pneumonia in two cases, and CMV pneumonia, pulmonary tuberculosis, candida pneumonia in one case each, respectively. We could perform open lung biopsy without mortality and significant morbidity. In view of the low positive predictive value of chest computed tomography scan and the very low morbidity of open lung biopsy, this procedure is recommendable for the diagnosis of invasive pulmonary aspergillosis and determination of its treatment. Am. J. Hematol. 71:75–79, 2002. © 2002 Wiley‐Liss, Inc.
Genomic Imprinting and Its Clinical Implications
Authors: Judith G. Hall
Journal: New England Journal of Medicine (1992)

What do rare conditions such as the Prader—Willi and Angelman syndromes have to do with the real world of the busy practitioner? They seem esoteric and exotic, and yet these rare syndromes are windows into the world of a newly recognized phenomenon of inheritance called genomic imprinting. Over the past few years, work in many different fields has demonstrated that there are "parent-of-origin" effects on the function of chromosomes and genes.1 , 2 In other words, for some genes and for parts of some chromosomes, it makes a difference whether they are inherited from the mother or from the father. The report . . .
Modulation of a Glycoprotein Recognition System on Rat Hepatic Endothelial Cells by Glucose and Diabetes Mellitus
Authors: John A. Summerfield, John Vergalla, E. Anthony Jones
Journal: Journal of Clinical Investigation (1982)

The cellular location and carbohydrate specificities of a glycoprotein recognition system on rat hepatic sinusoidal cells have been determined. Purified preparations of endothelial, Kupffer, and parenchymal cells were prepared by collagenase liver perfusion, centrifugation on Percoll gradients, and centrifugal elutriation. 125I-labeled agalactoorosomucoid, an N-acetylglucosamine-terminated glycoprotein, was selectively taken up in vitro by endothelial cells. Uptake was shown to be protein dependent, calcium ion dependent, and saturable, and could be described by Michaelis-Menten kinetics (apparent Km 0.29 μM; apparent maximum velocity 4.8 pmol/h per 5 × 106 cells). Uptake was inhibited not only by N-acetylglucosamine, mannose, and mannan but also by glucose, fructose, and a glucose-albumin conjugate. Inhibition by glucose was competitive over a wide range of concentrations and was almost 100% at a glucose concentration of 56 mM. Fasting and the induction of diabetes mellitus prior to isolation of cells was associated with 60% reductions in the recovery of endothelial cells. Uptake by cells isolated from fasted rats was enhanced (apparent maximum velocity 14.3 pmol/h per 5 × 106 cells without change in the apparent Km). These observations suggest that fasting is associated with a marked increase in the mean number of glycoprotein receptors per endothelial cell isolated from normal rats. This effect of fasting could be due to upregulation of glycoprotein receptors on endothelial cells or to the selective isolation of a subpopulation of endothelial cells from fasted animals that bears more glycoprotein receptors per cell than does another subpopulation of these cells. In addition, in vivo studies of the fate of intravenously administered 125I-agalactoorosomucoid indicated that its rate of disappearance from plasma, hepatic accumulation, and catabolism were slower in diabetic than in normal rats. The results suggest that modulation of a carbohydrate-mediated glycoprotein recognition system located on hepatic endothelial cells can be induced by glucose and glucose-conjugated proteins and by fasting and diabetes mellitus. The findings in this study suggest a mechanism for abnormal glycoprotein metabolism in diabetes mellitus.