OBSERVATIONS ON THE USE OF ACETYL BETA METHYLCHOLINE CHLORIDE IN CHRONIC ARTHRITIS
Authors: Douglas Boyd, Stafford L. Osborne, David E. Markson
Journal: Annals of Internal Medicine (1936)

Article1 December 1936OBSERVATIONS ON THE USE OF ACETYL BETA METHYLCHOLINE CHLORIDE IN CHRONIC ARTHRITISDOUGLAS BOYD, M.D., STAFFORD L. OSBORNE, B.P.E., DAVID E. MARKSON, M.D., F.A.C.P.DOUGLAS BOYD, M.D.Search for more papers by this author, STAFFORD L. OSBORNE, B.P.E.Search for more papers by this author, DAVID E. MARKSON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-6-728 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany investigators have studied the value of choline compounds in the treatment of conditions involving vascular spasm. Acetylcholine has long been known but, because of its nicotine-like action, is not suitable for therapeutic use. Major and Kline1synthesized acetyl beta methylcholine chloride, a more stable compound, free from the nicotine-like side effects of previous compounds. When Starr2compared the action of acetyl beta methylcholine with acetylcholine, he found they had similar effects on the cardio-vascular system of animals when given intravenously. He also found acetyl beta methylcholine chloride more than 10 times as active as acetylcholine when given hypodermically in...References1. MAJORKLINE RTJK: Preparation and properties of alpha and beta methylcholine and gamma-homocholine, Jr. Am. Chem. Soc., 1932, liv, 242-249. CrossrefGoogle Scholar2. STARRELSOMREISINGER IKAJA: Acetyl beta methylcholine. 1. The action on normal persons. 2. Its action on paroxysmal tachycardia and peripheral vascular disease, Am. Jr. Med. Sci., 1933, clxxxvi, 313-330. CrossrefGoogle Scholar3. WRIGHTPEMBERTON LMR: The peripheral surface temperature in arthritis, Arch. Int. Med., 1930, xlv, 147. CrossrefGoogle Scholar4. GOLDSMITH GA: The vasodilating effects of acetyl beta methylcholine, Proc. Staff Meet. Mayo Clinic, 1934, ix, 337. Google Scholar5. KATZ : Personal communication. Google Scholar6. KOTKISMELCHIONNAALEXANDERLUCIDO AJRHMFJ: Physiologic effects of acetyl beta methylcholine chloride by iontophoresis; preliminary report, Arch. Phys. Therapy, 1935, xvi, 528-533. Google Scholar7. KOVACS J: The iontophoresis of acetyl beta methylcholine chloride in the treatment of chronic arthritis and peripheral vascular disturbance; preliminary report, Am. Jr. Med. Sci., 1934, clxxxviii, 32. CrossrefGoogle Scholar8. KOVACSSAYLORWRIGHT JLLIS: The pharmacological and therapeutic effects of certain choline compounds, Am. Heart Jr., 1936, xi, 53. CrossrefGoogle Scholar9. JOHNSON CA: Studies on peripheral vascular phenomena, Surg., Gynec. and Obst., 1932, lv, 731. Google Scholar10. CECIL RL: Medical treatment of chronic arthritis, Jr. Am. Med. Assoc., 1934, ciii, 1583-1589. CrossrefGoogle Scholar11. HENCH PS: A consideration of muscular pain and fatigue with a note on glycine: preliminary comment, Proc. Staff Meet. Mayo Clinic, 1934, ix, 603. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication September 5, 1936.From the Departments of Medicine and Physical Therapy, Northwestern University Medical School, Chicago. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1936Volume 10, Issue 6Page: 728-741KeywordsAcetylcholineArthritisChlorides Issue Published: 1 December 1936 PDF downloadLoading ...