tbuckley/cabot-search huggingface dataset:
Genomic Technologies Speed Pathogen Detection
Authors: Joan Stephenson
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Historical Aspects of Cerebral Anatomy.
Authors: Alfred Charles Meyer
Journal: Annals of Internal Medicine (1971)

that their object has changed from that of the first edition, with its accent on undergraduate teaching; the aim is now to give a complete account of present thought on all aspects of the red blood cell.This has been comprehensively, as well as comprehensibly, done.The bibliography is full, and references are not biased to either side of the Atlantic.There is good fusion between physiological and clinical data (which is often lacking in smaller haematological text-books), although the descriptions of clinical manifestations do tend to chattiness.The fairly radical removal of discarded material to make way for the new is welcome, even although detailed treatment, which is most subject to fashion, is not described.This book is a must for anyone who is interested in haematology.
Inflammatory Bone Spur Formation in Psoriatic Arthritis Is Different From Bone Spur Formation in Hand Osteoarthritis
Authors: Stephanie Finzel, Enijad Sahinbegovic, Roland Kocijan, Klaus Engelke, Matthias Englbrecht, Georg Schett
Journal: Arthritis & Rheumatology (2014)

To investigate the different patterns of bone spur formation in psoriatic arthritis (PsA) and hand osteoarthritis (OA), using high-resolution peripheral quantitative computed tomography (QCT).The study group comprised 70 subjects (25 patients with PsA, 25 patients with hand OA, and 20 healthy controls). The 2 patient groups were similar with regard to age and sex distribution and clinical involvement of the metacarpophalangeal (MCP) joints. All patients underwent high-resolution peripheral QCT scanning of the second, third, and fourth MCP joints of the dominantly affected hand. Demographic and disease-specific data were recorded, and the number, size, and distribution of bone spurs were assessed and compared between patients with PsA and patients with hand OA.The overall number and size of bone spurs were similar in patients with PsA and patients with hand OA. However, localization of lesions within individual joints was substantially different between patients with PsA and those with hand OA. In PsA, bone spurs dominated the radial sides of the joints (for the metacarpal head of the second joint, P < 0.001 versus hand OA; for the base of the second phalangeal joint, P < 0.001 versus hand OA), whereas the palmar and dorsal quadrants were the predilection sites in hand OA. Detailed anatomic analysis showed that bone spurs in the entheseal regions were prominent in patients with PsA but rare in patients with hand OA, and that bone spurs in patients with hand OA typically emerged at the cartilage-bone interphase and the joint margins.Our findings show that the overall number and size of bone spurs are similar in patients with PsA and patients with hand OA. Nonetheless, the anatomic sites of bone proliferation are different between these 2 groups of patients.
Human CD34loCD133lo fetal liver cells support the expansion of human CD34hiCD133hi hematopoietic stem cells
Authors: Kylie Su Mei Yong, Choong Tat Keng, Shu Qi Tan, Eva Loh, Kenneth TE Chang, Thiam Chye Tan, Wanjin Hong, Qingfeng Chen
Journal: Cellular and Molecular Immunology (2015)
Cerebrospinal Fluid Aβ42, Phosphorylated Tau<sub>181</sub>, and Resting-State Functional Connectivity
Authors: Liang Wang, Matthew R. Brier, Abraham Z. Snyder, Jewell B. Thomas, Anne M. Fagan, Chengjie Xiong, Tammie L. Benzinger, David M. Holtzman, John C. Morris, Beau M. Ances
Journal: JAMA Neurology (2013)

Resting-state functional connectivity magnetic resonance imaging has great potential for characterizing pathophysiological changes during the preclinical phase of Alzheimer disease.To assess the relationship between default mode network integrity and cerebrospinal fluid biomarkers of Alzheimer disease pathology in cognitively normal older individuals.Cross-sectional cohort study at The Charles F. and Joanne Knight Alzheimer's Disease Research Center at Washington University in St Louis, St Louis, Missouri, among 207 older adults with normal cognition (Clinical Dementia Rating, 0).Resting-state functional connectivity magnetic resonance imaging measures of default mode network integrity.Decreased cerebrospinal fluid Aβ42 and increased cerebrospinal fluid phosphorylated tau181 were independently associated with reduced default mode network integrity, with the most prominent decreases in functional connectivity observed between the posterior cingulate and medial temporal regions. Observed reductions in functional connectivity were unattributable to age or structural atrophy in the posterior cingulate and medial temporal areas. Similar resting-state functional connectivity magnetic resonance imaging findings in relation to cerebrospinal fluid biomarkers were obtained using region-of-interest analyses and voxelwise correlation mapping.Both Aβ and tau pathology affect default mode network integrity before clinical onset of Alzheimer disease.
Gluten-free diet in dermatitis herpetiformis.
Authors: T. REUNALA, K. BLOMQVIST, S. TARPILA, H. HALME, K. KANGAS
Journal: British Journal of Dermatology (1977)

Eighty-one patients with dermatitis herpetiformis were treated with a gluten-free diet (GFD) for periods varying from 6 to 36 months. At the end of the treatment the daily requirement of dapsone was significantly lower in patients treated with a GFD than in 49 patients on a normal diet. 93% of the patients on a GFD were able to reduce the dose of dapsone whereas only 16% of the patients on a normal diet were able to do this. Complete remissions occurred only in patients on a GFD. 28% of the patients on a GFD were able to stop dapsone completely and were continuously asymptomatic when they observed a strict diet. A response to a GFD was noted on the mean daily requirement of dapsone as soon as the treatment was initiated although the length of time for an individual response varied. After one year on a GFD the patients needed on average about 40% and after 3 years about 20% of the dose required to control skin symptoms at the beginning of the diet. The patients responded to a GFD irrespective of changes found in the jejunal mucosa and irrespective of the presence of absence of HLA-B8.
Clinical Factors and Recurrent Venous Thrombotic Events
Authors: Bradley Flansbaum
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pain and the Brain
Authors: Joan Stephenson
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The p53 via Chk2 pathway is synergized by p38 MAPK signaling to mediate 11,11’-dideoxyverticillin-induced G2/M arrest
Authors: Yi Chen, Ze-Hong Miao, Wei-Min Zhao, Yun-Guang Tong, Jian Ding
Journal: Cancer Research (2005)

2268   The phytochemical 11,11’-dideoxyverticillin, derived from the fungus Shiraia bambusicola, has been shown to possess potent anticancer activity in a variety of human cancer cell lines and anti-angiogenetic effect against numerous in vitro and in vivo models. Here, we investigated the effect of 11,11’-dideoxyverticillin on cell cycle progression, and explored the potential mechanisms for this effect. Cell cycle regulation is a complicated process involving many signaling molecules interacting in ways that are not yet fully understood. This study clarifies the relationships among p53, Chk2, and p38 MAPK on the basis of evaluating their roles in 11,11’-dideoxyverticillin-elicited G2/M arrest. The experimental result revealed that the compound could arrest HCT-116 cells in G2/M phase in a dose- and time-dependent manner, in a process associated with increases in p53, phospho-p53 and phospho-Chk2 protein levels. p53 siRNA abrogated the enhancement of p53 and phospho-p53 proteins, and protected HCT-116 cells against 11,11’-dideoxyverticillin-induced G2/M arrest, indicating that p53 signaling plays an important role in 11,11’- dideoxyverticillin-induced cell cycle arrest. Moreover, phosphorylation of Chk2 was enhanced by 11,11’-dideoxyverticillin treatment, and this enhancement was eliminated by application of p53 siRNA. Simultaneously, 11,11’-dideoxyverticillin treatment also elicited p38 MAP kinase activity and expression of phospho-p38 MAPK. Treatment with a specific p38 MAPK inhibitor (SB203580) successfully inhibited p38 MAPK and delayed the onset of G2/M arrest induced by 11,11’-dideoxyverticillin after approximately 6 h (as compared to 1 h in cells not treated with the inhibitor), but did not abolish the induction of G2/M arrest. Additionally, SB203580 did not alter the levels of p53, phospho-p53, or phospho-Chk2 proteins in 11,11’-dideoxyverticillin-treated cells. Together, these findings indicate that p53-mediated phosphorylation of Chk2 plays a vital role in 11,11’-dideoxyverticillin-induced G2/M arrest, and that p38 MAPK might accelerate this progression. Our work suggests a possibility of interactions among p53, Chk2 and p38 MAPK signaling in G2/M arrest and allow us to further understand the molecular mechanisms by which 11,11’-dideoxyverticillin exerts its anticancer activities. Nevertheless, some molecular links remain to be clarified, such as how the p53 signaling is connected to Chk2, and how p38 signaling acts on the p53 pathway.
Press: In the grip of spin
Authors: K. Abbasi
Journal: BMJ (1999)

23 year old Martin Bryant entered a tourist complex 100 km south of Hobart, Tasmania, and shot dead 35 people, wounding 18 others.The media described it as "the worst massacre by a single gunman in Australian history," although Chapman points out on page 1 that the wholesale slaughter of aborigines in the 19th century often involved far higher individual tallies. Beforethis watershed tragedy, Australia's eight states and territories had different laws.In practice, they operated on or below the lowest denominator (ironically, that of Tasmania).For years, attempts to limit gun ownership had floundered in political backwaters, fobbed off by politicians cowed by vocal pro-gun lobbyists.After the massacre, obfuscation was cut through and a practical national gun agreement put in place.This included a ban on semiautomatic and pump action rifles, a compensatory buy back scheme, a register of all firearms, shooter licensing based on a "genuine reason for owning a firearm," safe storage requirements, and uniform national laws.Myths surrounding gun control abound."Guns don't kill people, people do" has had a successful run in the United States, but the Australian public simply did not buy this argument.I cheered when the epidemiological arsenal of sensitivity, specificity, and power was used to knock the stuffing out of arguments for a prohibited persons register; to prevent 570 assaults yet miss 30 each year in New Zealand alone would entail locking up 150 000 Kiwis.
Medical Research in Pedophilia
Authors: Domeena C. Renshaw
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Erkeklerde androgenetik alopesi tedavisinde topikal %5 minoksidil köpük ile plasebonun karşılaştırıldığı çok merkezli, randomize, plasebo kontrollü, çift kör bir klinik çalışma
Authors: Elise A. Olsen, David Whiting, Wilma Bergfeld, Jeffrey Miller, Maria Hordinsky, Rita Wanser, Paul Zhang, ve Bruce Kohut Durham, North Carolina, Dallas, Texas, Cleveland, Ohio, Hershey, Pennsylvania, Minneapolis, Minnesota, Morris Plains, New Jersey
Journal: Journal of the American Academy of Dermatology (2008)
Abstract 19568: Hemodynamic Assessment of an Augmented Aorta: a Rapid Prototyping Technique
Authors: Kevin A Gralewski, Kevin K Whitehead, Yoav Dori
Journal: Circulation (2014)

Introduction: Interest in high fidelity aortic flow phantoms remains significant even with advancements in computational fluid dynamic methods. We present a process for creating a patient-specific, compliant aortic arch and valve (AoV) along with our corresponding validation efforts. Methods: A rendered aortic volume was created by threshold-based segmentation in Mimics (Materialise, Leuven, Belgium) and edited in 3-matic to create a 3D printed mold (Object Connex 5000, Stratasys, Edina, Minnesota) into which a polyurethane based resin (Smooth-on, Easton, Pennsylvania) was cast. The AoV was created in a similar manner and ultimately seated in the distal end of an inlet port designed to induce laminar flow. The arch, with fixed inlet, was then constrained to the correct anatomical conformation by a custom rapid prototyped chamber. An MRI-compatible pump programmed to match the patient’s flow profile managed flow of a 40% glycerin-aqueous solution. Both through-plane and 4D phase contrast velocity mapping MRI sequences were acquired and compared to the patient data with time-elapse flow streamlines calculated by GTFlow version 2.0.1 (GyroTools, Zurich Switzerland). Results: The phantom remained robust and compliant throughout the dynamic loading occurring under pulsatile flow. Registration revealed good alignment of the phantom lumen to the segmented patient aorta. 4D flow analysis showed an unusual left-handed helical flow pattern in both the in vivo patient data and derived phantom flows. Flow measurements in the ascending and descending aorta of the model agreed within 5% of the actual patient measured flow. Conclusions: We have demonstrated a viable method to create patient-specific flow phantoms, which closely mimic the physiological system for which they are modeled. Further studies are needed to optimize the valve anatomy and wall compliance.
Chest wall motion and volume changes with and without non-invasive ventilation in patients with amyotrophic lateral sclerosis
Authors: Cristiana Magalhães, Mauro Vidigal, Danielle Vieira, Bruna Vieira, Verônica Parreira
Journal: European Respiratory Journal (2012)

In Amyotrophic Lateral Sclerosis (ALS), inspiratory, expiratory, and bulbar muscles are altered, leading to chronic respiratory failure. Non-invasive ventilation (NIV) can be used to improve gas exchange in this patient population. Aim: to analyze the chest wall motion and operational volume changes in patients with ALS with and without NIV in the supine position. Ten patients with ALS, aged 54±13 years were included. Optoelectronic plethysmography (BTS, Milan, Italy) was used to measure: tidal volume of the chest wall (VtTcw), tidal volume of the pulmonary rib cage (Vtrcp), tidal volume of the abdominal rib cage (Vtrca), tidal volume of the abdomen (Vtab), end-inspiratory (Veicw) and end-expiratory (Veecw) volumes of the chest wall, respiratory frequency (f) and minute ventilation (VE). All patients were evaluated in the supine position with and without NIV for five minutes (Trilogy 100, Respironics, USA) NIV was used in the spontaneous/timed mode, with inspiratory and expiratory pressures of 14 cmH2O and 4 cmH2O, respectively.Paired t-tests were used for statistical analyses (p  Conclusion: NIV led to significant increases in tidal, end-inspiratory, and end-expiratory volumes, with no changes in the contributions of the three chest wall compartments.  Partly supported by FAPEMIG and CNPq.
Abstract 16542: Gravitational Based Therapy for POTS: An International Registry Evaluating the Success of a Structured, Graduated Exercise Program Administered in a Community Setting
Authors: Stephen A George, Tiffany B Bivens, Dianne Hendrickson, Melyn Galbreath, Qi Fu, Benjamin D Levine
Journal: Circulation (2012)

Postural Orthostatic Tachycardia Syndrome (POTS) is a debilitating syndrome of orthostatic intolerance resulting in lightheadedness, fatigue, and syncope leading to a dramatically reduced quality o...
Pathways to clean hands: highlights of successful hand hygiene implementation strategies in Europe
Authors: A P Magiorakos, E Leens, V Drouvot, L May-Michelangeli, C Reichardt, P Gastmeier, K Wilson, M Tannahill, E McFarlane, A Simon
Journal: Eurosurveillance (2010)

Hand hygiene is the most effective way to stop the spread of microorganisms and to prevent healthcare-associated infections (HAI). The World Health Organization launched the First Global Patient Safety Challenge - Clean Care is Safer Care - in 2005 with the goal to prevent HAI globally. This year, on 5 May, the WHO s initiative SAVE LIVES: Clean Your Hands, which focuses on increasing awareness of and improving compliance with hand hygiene practices, celebrated its second global day. In this article, four Member States of the European Union describe strategies that were implemented as part of their national hand hygiene campaigns and were found to be noteworthy. The strategies were: governmental support, the use of indicators for hand hygiene benchmarking, developing national surveillance systems for auditing alcohol-based hand rub consumption, ensuring seamless coordination of processes between health regions in countries with regionalised healthcare systems, implementing the WHO's My Five Moments for Hand Hygiene, and auditing of hand hygiene compliance.
Expression pattern of T-cell–associated chemokine receptors and their chemokines correlates with specific subtypes of T-cell non-Hodgkin lymphoma
Authors: Dan Jones, Carl O'Hara, Madeleine D. Kraus, Antonio R. Perez–Atayde, Aliakbar Shahsafaei, Lijun Wu, David M. Dorfman
Journal: Blood (2000)
Facial basal cell carcinomas treated with hypo-fractionated radiotherapy: A retrospective analysis in 117 elderly patients
Authors: Antonio Pelissero, Elvio G. Russi, Antonella Melano, Claudia Fillini, Riccardo Vigna-Taglianti, Nicola Settineri, Francesco Lucio, Giampiero Girolomoni, Stefano Pergolizzi
Journal: Journal of the American Academy of Dermatology (2015)
Visual conscious perception could be grounded in a nonconscious sensorimotor domain
Authors: Ulrich Ansorge, Ingrid Scharlau, Manfred Heumann, Werner Klotz
Journal: Behavioral and Brain Sciences (2001)

Visual conscious perception could be grounded in a nonconscious sensorimotor domain. Although invisible, information can be processed up to the level of response activation. Moreover, these nonconscious processes are modified by actual intentions. This notion bridges a gap in the theoretical framework of O'Regan &amp; Noë.
ISOLATION OF MUMPS VIRUS FROM HUMAN BEINGS WITH INDUCED APPARENT OR INAPPARENT INFECTIONS
Authors: Gertrude Henle, Werner Henle, Katherine K. Wendell, Philip Rosenberg
Journal: The Journal of Experimental Medicine (1948)

Exposure of fifteen children to mumps virus of fifth amniotic passage in chick embryos led to involvement of the salivary glands in six, orchitis in the absence of other manifestations of mumps in one, and to no signs of illness in eight. Attempts to isolate virus from the saliva of these individuals gave the following results: 1. All patients with involvement of the salivary glands excreted virus beginning on the 11th to 15th day after exposure, 2 to 6 days prior to onset of clinical signs of disease and extending up to the 4th day of illness. 2. The patient with primary orchitis without any recognized involvement of the salivary glands excreted virus for 2 days, beginning on the 15th day after exposure and 10 days prior to his illness. 3. Six of the eight children classified as having inapparent infections because of their serologic response in the absence of clinical signs of illness, began to excrete virus on the 15th to 16th day after exposure for from 1 to 9 or more days. The epidemiologic significance of these data is discussed.