STUDIES OF URINARY PIGMENTS IN PELLAGRA AND OTHER PATHOLOGICAL STATES. I. CLINICAL OBSERVATIONS
Authors: Cecil James Watson, John A. Layne
Journal: Annals of Internal Medicine (1943)

Article1 August 1943STUDIES OF URINARY PIGMENTS IN PELLAGRA AND OTHER PATHOLOGICAL STATES. I. CLINICAL OBSERVATIONSCECIL JAMES WATSON, M.D., F.A.C.P., JOHN A. LAYNE, M.D.CECIL JAMES WATSON, M.D., F.A.C.P.Search for more papers by this author, JOHN A. LAYNE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-2-183 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn previous communications,1, 2one of us (C. J. W.) pointed out that the Ellinger-Dojmi color reaction3is due to urorosein, and that porphyrin, although capable of yielding color if present in sufficient amount, was not the source of the positive reactions encountered in urine samples from a variety of conditions, including pellagra. Beckh, Ellinger and Spies4had employed the Ellinger-Dojmi reaction for the quantitative estimation of porphyrin in the urine. These investigators reported marked increases of porphyrin in a series of pellagra urines. They stated, moreover, that the administration of nicotinic acid was followed by a prompt fall in...Bibliography1. WATSON CJ: The urinary pigments in four cases of alcoholic pellagra, Proc. Soc. Exper. Biol, and Med., 1938, xxxix, 514-518. CrossrefGoogle Scholar2. WATSON CJ: Further observations on the red pigments of pellagra urines, Proc. Soc. Exper. Biol, and Med., 1939, xli, 591-595. CrossrefGoogle Scholar3. ELLINGERDOJMI PL: Note on the presence of porphyrine in the urine of pellagra patients, Chemistry and Industry, 1935, liv, 507. Google Scholar4. BECKHELLINGERSPIES WPTD: Porphyrinuria in pellagra, Quart. Jr. Med., 1937, vi, 305-319. Google Scholar5. SYDENSTRICKERSCHMIDTFULTONNEWGEESLIN VPHLMCJSLE: Treatment of pellagra with nicotinic acid: Observations in 45 cases, South. Med. Jr. 1938, xxxi, 1155-1163. CrossrefGoogle Scholar6. 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