tbuckley/cabot-search huggingface dataset:
Peripheral Neuropathies in Systemic Lupus Erythematosus: Clinical Features, Disease Associations, and Immunologic Characteristics Evaluated Over a Twenty‐Five–Year Study Period
Authors: A. Oomatia, H. Fang, M. Petri, J. Birnbaum
Journal: Arthritis & Rheumatology (2013)

Objective To characterize peripheral neuropathy subtypes, ancillary studies, and immunologic profiles associated with peripheral neuropathies in patients with systemic lupus erythematosus (SLE). Methods In this 25‐year study of 2,097 SLE patients, we characterized peripheral neuropathies due to SLE and compared clinical and SLE‐related features in patients with versus those without neuropathy. Results The prevalence of peripheral neuropathies was 5.9% (123 of 2,097 patients), and 66.7% of these patients (82 of 123) had peripheral neuropathies attributable to SLE. We noted that 17.1% of the patients with peripheral neuropathies due to SLE (14 of 82 patients) had small‐fiber neuropathy, which is a painful neuropathy not included in the American College of Rheumatology (ACR) neuropsychiatric SLE (NPSLE) case definitions. SLE patients with small‐fiber neuropathies could present with unorthodox neuropathic pain patterns not consistent with a stocking–glove distribution and had associated skin biopsy results suggestive of dorsal root ganglion neuronal cell loss. Compared to SLE patients without peripheral neuropathies, those with peripheral neuropathies had lower mean disease activity ( P = 0.01) and higher disease damage ( P &lt; 0.01) and were more likely to have a history of herpes zoster virus infection ( P &lt; 0.01), osteoporotic fractures ( P &lt; 0.01), and opportunistic infections ( P &lt; 0.01). Conclusion Our findings indicate that small‐fiber neuropathy is a frequently occurring peripheral neuropathy. The skin biopsy findings in small‐fiber neuropathy patients support the notion that distinct mechanisms target the dorsal root ganglia as well as distal axons. SLE patients with peripheral neuropathy have lower mean disease activity scores and higher disease damage. Our findings suggest that revision of the ACR NPSLE case definitions, which currently do not include small‐fiber neuropathies, is warranted.
Inter-instrument variability in exhaled nitric oxide measurement and implications on test interpretation
Authors: Jeffrey Pretto, Brenton Eckert, Jodie Simpson, Heather Powell, John Upham, Peter Gibson
Journal: European Respiratory Journal (2014)

Differences in measurement of fractional exhaled nitric oxide (FeNO) between instruments is well documented, but the clinical implications of these differences using the 2011 ATS FeNO interpretation guidelines (AJRCCM, 2011; 184:602) has not been described. Aims: To document inter-instrument variability in FeNO measurements from 3 devices and to assess the implications of this variability on how results are interpreted in an adult clinical cohort. Methods: Comparisons between a handheld device (NIOX MINO) and 2 chemoluminescence devices (Ecomedics CLD88-comparison A, and Sievers NOA 280i-comparison B) were made. Using ATS interpretative cut-point criteria of 25ppb and 50ppb, the diagnostic performance of the MINO in identifying abnormal FeNO results was assessed using the chemoluminescence systems as standards. Results: Mean (SD) difference for comparison A in 94 adults (18M:76F) across the 5-98ppb range was small at 0.2 (8.8)ppb. Interpretation agreement between devices was 94.7% using both cut-points. MINO tended to read lower for comparison B in 73 adults (33M:40F) across the 5-131ppb range with difference of 8.8 (9.6)ppb. Interpretation agreement was 87.7%. For both comparisons there were tight relationships with simple linear modelling enabling precise correction of inter-instrument differences (A: Y= 1.16x-3.81. R =0.94, p<0.01. B: Y= 1.25x-0.733. R = 0.98, p<0.01). Conclusions: FeNO measurements from the hand-held MINO device compare favourably with more expensive chemiluminescence analysers with simple corrections enabling comparable instrument readings. Inter-instrument differences resulted in 7% misclassification rate for clinical interpretation (12 of 167 subjects).
Digital compression of facial arteries facilitates cutaneous nasal surgery
Authors: B. Moran, C. Foley, P. Ormond
Journal: British Journal of Dermatology (2013)

Funding sources: none. Conflicts of interest: none declared. Madam, Nonmelanoma skin cancers on the nose frequently present to dermatology for surgical excision. This anatomical area has an excellent vascular supply and, consequently, increased intraoperative bleeding (Fig. 1a). Pinching the nasal tip to control bleeding is commonly used; however, this can be uncomfortable for the patient because the nasal septum may not be anaesthetized (Fig. 1b). In addition, the patient has to open their mouth to breathe, which some people find uncomfortable, particularly when there is movement of the operators’ hands, swabs, blood, etc. in the immediate vicinity of the mouth. We describe a simple technique routinely used in our department to safely minimize intraoperative haemorrhage during cutaneous nasal surgery, allowing the patient the choice of breathing through the mouth or nose. The blood supply to the inferior nasal skin is largely provided by the inferiorly based facial artery. The facial artery terminates as the angular artery after giving off the inferior and superior labial and lateral nasal branches, and follows a course along the lateral side of the nose1–3 (Fig. 2).
South Korean government restricts prescribing to cover debt
Authors: Anne Gulland
Journal: BMJ (2001)

The South Korean government is again on a collision course with the medical profession after it enforced restrictive prescribing practices on doctors in a bid to cut a $3bn (£2bn) debt.

The health and welfare ministry has ordered doctors to prescribe generic drugs only and has warned that those who violate this rule will not be reimbursed.

The government has been forced to take such drastic measures because of a $3bn hole in the budget of the National Health Insurance Corporation. The action comes just …
Abstract 46: Meta-analysis of Endotracheal Intubation Versus Supraglottic Airway Placement by Emergency Medical Services During Out-of-Hospital Cardiac Arrest
Authors: Justin L Benoit, Ryan B Gerecht, Michael T Steuerwald, Jason T McMullan
Journal: Circulation (2014)

Objective: Patients frequently undergo advanced airway management during out of hospital cardiac arrest (OHCA) resuscitation attempts. Recent observational data has associated endotracheal intubation (ETI) with worse outcomes and unacceptable failure rates. Supraglottic airways (SGA) are easier to insert, but the comparative effectiveness of this intervention is unclear. The objective of this study was to analyze all available data comparing patient outcomes for these two airway methods in OHCA patients treated by emergency medical services (EMS). Methods: A dual-reviewer search was conducted in PubMed, Embase, and the Cochrane Database with a research librarian to identify all relevant peer-reviewed articles. Exclusion criteria were traumatic arrests, pediatric patients, physician/nurse intubators, rapid sequence intubation, video devices, devices solely obstructing the esophagus, and studies using identical datasets. Outcomes were evaluated in two categories: (1) Early survival (return of spontaneous circulation or survival to hospital admission), and (2) Late survival (survival to discharge or neurologically intact survival). Results were summarized using odds ratios and combined using meta-analytic techniques, Cochran’s Q test, and the random effects model. Results: From 3,454 titles, we reviewed 325 abstracts, yielding 5 observational studies that fulfilled all criteria, with 60,635 ETI patients and 246,506 SGA patients. Important covariates such as age, gender, initial cardiac rhythm, witness status, and bystander CPR, were similar between patient groups in all studies. Significant study-level heterogeneity was present for both early survival (I2 = 87.3%, p &lt; 0.001) and late survival (I2 = 66.1%, p = 0.001). Patients who received ETI had statistically significant higher odds of early survival (odds ratio 1.37, 95% confidence interval 1.04-1.81) but similar odds of late survival (odds ratio 1.17, 95% confidence interval 0.86-1.61) compared to SGA. Conclusion: Patients with OHCA treated by EMS are more likely to achieve return of spontaneous circulation or survive to admission after ETI compared to SGA, but this does not change ultimate survival. A randomized control trial is needed to further evaluate these associations.
Diabetes, dyslipidemia, and death from hepatocellular carcinoma in the middle‐aged and elderly
Authors: Timothy J.S. Cross
Journal: Hepatology (2014)

Potential conflict of interest: Nothing to report. To the Editor: I read with interest the article by Chiang et al.1 exploring the risk of death from hepatocellular carcinoma (HCC) in patients aged 40 years or older with diabetes and dyslipidemia. In short, the article concluded that diabetic patients should be enrolled in HCC surveillance to reduce cancer‐related death and also that further research should be done to explain why dyslipidemia may be related to a lower risk of death from HCC. The results are at first intriguing, but due to the methodology employed in this study I would be hesitant to make such bold assertions. First, the reliability of self‐reported questionnaires to make medical diagnosis and to assess alcohol consumption, smoking history, and physical activity are inherently unreliable. This could, therefore, have impacted the reported results. Furthermore, the duration of disease, e.g., diabetes and metabolic syndrome are likely to be important factors in the subsequent development of HCC. The authors also rightly point out that the effect of occult hepatitis B virus infection is unknown. In a Western population this is unlikely to be significant, but in the population under study, where cases of HCC are often attributable to chronic hepatitis B infection, this becomes more relevant. Moreover, the commonest causes of death in diabetes and the metabolic syndrome are cardiovascular in nature.2 To put the results in context, it would be useful to know the proportions of cardiovascular deaths so as to understand the true impact of the HCC‐related deaths. Many dyslipidemic patients may be dying from this mode of death, and therefore are not living long enough to develop HCC. The lag time analysis employed would miss these patients. Hence, the observed protective effect of dyslipidemia may in fact be a statistical quirk and may not be representative of all diabetes‐related deaths. Finally, the benefits of screening for HCC remain controversial. A recent article from the UK stated that over 20% of HCC cases in patients with nonalcoholic steatohepatitis (NASH) occurred in noncirrhosis patients.3 While the benefits of surveillance remain unproven in a well‐defined group of patients at risk of HCC, i.e., patients with cirrhosis, the proposal to broaden HCC surveillance to patients with diabetes seems premature. Given the epidemic of diabetes, the health economics of such a proposal would need to be better understood before its implementation. That money might be better spent on prevention of diabetes and prevention of cardiovascular death.
A multi‐allergen standard for the calibration of immunoassays: CREATE principles applied to eight purified allergens
Authors: S. Filep, A. Tsay, L. Vailes, G. Gadermaier, F. Ferreira, E. Matsui, E. M. King, M. D. Chapman
Journal: Allergy (2011)

To cite this article: Filep S, Tsay A, Vailes L, Gadermaier G, Ferreira F, Matsui E, King EM, Chapman MD. A multi‐allergen standard for the calibration of immunoassays: CREATE principles applied to eight purified allergens. Allergy 2012; 67 : 235–241. Abstract Background: Allergen measurements are widely used for environmental exposure assessments and for determining the potency of allergen vaccines, yet few purified allergen standards have been developed. The aim of the study was to develop a single standard containing multiple purified allergens that could be used in enzyme immunoassays and in multiplex arrays for the standardization of allergen measurements. Methods: Eight purified allergens were formulated into a single multi‐allergen, or ‘universal’, standard based on amino acid analysis. Dose–response curves were compared with previous individual ELISA standards and allergen measurements of house dust extracts to obtain correction factors. Measured allergen concentrations were also modeled using linear regression, and the predictive accuracy was determined. Results: Parallel dose–response curves were obtained between the universal allergen standard and the individual ELISA standards, with close agreement between curves for 5/8 allergens. Quantitative differences of greater than twofold were observed for Fel d 1, Can f 1, and Der f 1, which were confirmed by the analysis of house dust extracts. Correction factors were developed that allowed ELISA data to be expressed in terms of the universal standard. Linear regression data confirmed the predictive accuracy of the universal standard. Conclusion: This study shows that a single standard of eight purified allergens can be used to compare allergen measurements by immunoassay. This approach will improve the continuity of environmental exposure assessments and provide improved standardization of allergy diagnostics and vaccines used for immunotherapy.
Abstract 2703: Persistence and Outcomes of Ischemic Mitral Regurgitation
Authors: Mario Senechal, Julien Magne, Philippe Pibarot, Francois Dagenais, Zeineb Hachicha, Jean-Gaston Dumesnil
Journal: Circulation (2006)

Objective: Previous studies have demonstrated that ischemic mitral regurgitation (MR) often persists or recurs after restrictive mitral valve annuloplasty (MVA) and adversely affects patient’s outc...
Abstract 3609: Fibroblast influence on keratinocyte tumorigenic and metastatic potential in cutaneous squamous cell carcinoma
Authors: J Curtis Gwilliam, Alexander CVitan, Nicholas Watson, Lauren Falkenberg, Nyousha Yousefi, Hepzibha Alexander, Adam Morin, Jonathan S. Wiest, Katie L. DeCicco-Skinner
Journal: Cancer Research (2014)

Abstract Skin cancer is the most common form of cancer in the United States, with an estimated two million cases diagnosed annually. Tpl2 (Map3k8) is a serine threonine protein kinase in the mitogen-activated protein kinase (MAPK) signal transduction cascade. Tpl2 was identified by our laboratory as having a tumor suppressive function in skin carcinogenesis, with Tpl2 knockout mice developing significantly more tumors than matched wildtype controls and Tpl2 knockout keratinocytes having greater angiogenic and metastatic potential. However, the microenvironmental contributions of underlying fibroblasts to the cancerous behavior seen in Tpl2 knockout keratinocytes has yet to be characterized. Therefore, we compared the tumorigenic, invasive, and metastatic potential of H-ras infected keratinocytes from wildtype and Tpl2 knockout mice with H-ras infected keratinocytes co-cultured with fibroblasts from wildtype and Tpl2 knockout mice. Using various techniques, including protein microarray, real-time polymerase chain reaction and Western blotting we found that fibroblasts in the microenvironment of H-ras-infected Tpl2 knockout keratinocytes contribute to an up-regulation of markers involved in growth and progression of squamous cell carcinoma. Additionally, Tpl2 knockout keratinocytes cultured in fibroblast conditioned media (FCM) have higher malignant conversion rates, colony formation and increased angiogenesis compared to co-cultured wildtype keratinocytes. In summary, our studies demonstrate that fibroblasts in the tumor microenvironment of Tpl2 knockout mice play a major role in the more aggressive,invasive, and metastatic character of knockout tumors than is seen in control animals. Citation Format: J Curtis Gwilliam, Alexander CVitan, Nicholas Watson, Lauren Falkenberg, Nyousha Yousefi, Hepzibha Alexander, Adam Morin, Jonathan S. Wiest, Katie L. DeCicco-Skinner. Fibroblast influence on keratinocyte tumorigenic and metastatic potential in cutaneous squamous cell carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3609. doi:10.1158/1538-7445.AM2014-3609
120. Transient Saturation of the Reticuloendothelial System by Non-Cytotoxic Liposomes Increases Hepatocyte Transduction after Adenoviral Gene Transfer
Authors: Jan Snoeys, Geertrui Mertens, Joke Lievens, Désiré Collen, Eric Biessen, Bart De Geest
Journal: Molecular Therapy (2004)

Background: Depletion of tissue macrophages and dendritic cells in liver and spleen by administration of liposomes encapsulating dichloromethylene-biphosphonate results in reduced transgene DNA elimination in the liver in the first 24 hours after adenoviral transfer. However, repopulation of macrophages in the spleen after administration of these liposomes is still incomplete after two months and the inherent cytotoxicity of this strategy excludes its clinical applicability. To enhance parenchymal liver cell transduction, the effect of saturation of the reticuloendothelial system by administration of non-cytotoxic empty egg yolk phosphatidylcholine liposomes was evaluated.
Proteomic biomarkers of recovered heart function
Authors: Zsuzsanna Hollander, Marie Lazárová, Karen K.Y. Lam, Andrew Ignaszewski, Gavin Y. Oudit, Jason R. B. Dyck, George Schreiner, Julie Pauwels, Virginia Chen, Gabriela V. Cohen Freue, Raymond T. Ng, Janet E. Wilson‐McManus, Robert Balshaw, Scott J. Tebbutt, Robert W. McMaster, Paul A. Keown, Bruce M. McManus
Journal: European Journal of Heart Failure (2014)
TUBERCULOMA OF THE SPINAL CORD
Authors: F. L. Jennings
Journal: Annals of Internal Medicine (1934)

Article1 April 1934TUBERCULOMA OF THE SPINAL CORDF. L. JENNINGS, M.D., F.A.C.P.F. L. JENNINGS, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-10-1240 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTuberculoma of the spinal cord may develop within the substance of the cord itself (the intramedullary form), or within the spinal canal external to the cord (the extramedullary form). The following report is of a case of intramedullary tuberculoma. Such instances are of infrequent occurrence. The case reported is the only one observed in the 5,344 tuberculous patients in our records. Kernohan, Woltman and Adson1in a group of 51 cases of intramedullary cord tumors found only one case of tuberculoma. In 1922 Thalhimer reviewed the literature and collected 52 reported cases of intramedullary tuberculoma of the spinal cord; with...Bibliography1. KERNOHANWOLTMANADSON JWHWAW: Intramedullary tumors of spinal cord; review of 51 cases with attempt at histologic classification, Arch. Neurol. and Psychiat., 1931, xxv, 679-701. CrossrefGoogle Scholar2. THALHIMERHASSIN WGB: Clinico-pathologic notes on solitary tubercle of spinal cord, Jr. Nerv. and Ment. Dis., 1922, lv, 161-193. CrossrefGoogle Scholar3. DANDY WE: The diagnosis and localization of spinal cord tumors, Ann. Surg., 1925, lxxxi, 223-254. CrossrefGoogle Scholar4. ANDERSON FN: Tuberculoma of central nervous system, Arch. Neurol. and Psychiat., 1928, xx, 354-365. Personal communication May 18, 1932. CrossrefGoogle Scholar5. WARING JJ: A case of tuberculoma of spinal cord, Jr. Lab. and Clin. Med., 1921-22, vii, 96-99. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Oak Terrace, Minnesota*Received for publication October 16, 1933. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySpinal Intramedullary Tuberculosis with Concurrent Supra- and Infratentorial Intracranial Disease in a 9-Month-Old Boy: Case Report and Comprehensive Review of the LiteratureIntramedullary cervical tuberculomaIntramedullary tuberculoma: Report of two cases with MRI findingsTuberculoma intramedular solitario: relato de um casoRaumbeengende Prozesse im Spinalkanal (einschließlich Angiome und Parasiten)Isolated Intraspinal Extradural TuberculosisIntramedullary Tuberculoma of the Spinal CordZur Behandlung der tuberkul�sen Erkrankungen im Bereich des Spinalkannals 1 April 1934Volume 7, Issue 10Page: 1240-1243KeywordsSpinal cord ePublished: 1 December 2008 Issue Published: 1 April 1934 PDF downloadLoading ...
A Comparison of the Electrophoretic Mobility of Gardner Lymphosarcoma Cells in the Presence of Normal and Post-Tumor-Regression C3H Mouse Serums
Authors: Roberta S. Hartman, W. J. Nungester
Journal: Cancer Research (1956)

Data are given which show that ( a ) the serum from normal C3H mice contains a substance(s) which is adsorbed by the cells of the Gardner lymphosarcoma 6C3HED with some tenacity and ( b ) either a new substance(s) or an increased amount of the same substance(s) is present in the serum after the spontaneous regression of the tumor.
Book: Evidence Based Cardiology
Authors: J. R Hampton
Journal: BMJ (1998)

Salim Yusuf, John A Cairns, A J Camm, Ernest L Fallen, Bernard J Gersch BMJ Books, £130, pp 1200 ISBN 0 7279 1171 6 Rating: ![Graphic][1]</img>![Graphic][2]</img> Studies comparing clinical practice in different countries always show a remarkable lack of consistency in the way patients are treated. In cardiovascular disease there is a huge variation in, for example, the use of coronary angiography and percutaneous transluminal coronary angioplasty after acute myocardial infarction, and even in the use of relatively cheap treatments such as digoxin and diuretics in patients with heart failure. Why should this happen? The medical community is international, there is little debate about which are the leading journals, everyone goes to the same international meetings, and everyone has essentially the same access to the evidence on which treatment is supposedly based. One would have thought that there would be considerable consistency in the investigation and treatment of patients with … [1]: F1/embed/inline-graphic-1.gif [2]: F1/embed/inline-graphic-2.gif
Book: Evaluating Health Promotion
Authors: D. Nutbeam
Journal: BMJ (1999)

Ed David Scott, Ross Weston Stanley Thornes, £18, pp 176 ISBN 07487 33132 ——————— Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> This is a collection of essays that provide a range of perspectives on evaluation. Readers hoping for practical advice on how to conduct an evaluation will be disappointed. The target audience for the book is not clearly defined, but it is certainly not those with a peripheral or early interest in evaluating health promotion programmes. The book instead takes the reader on a tour of different models, evaluation designs, and measures of success for the … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif