GOITER AND MYXEDEMA DUE TO IODIDE ADMINISTRATION
Authors: B BURROWS, A H NIDEN, W R BARCLAY
Journal: Annals of Internal Medicine (1960)

Article1 April 1960GOITER AND MYXEDEMA DUE TO IODIDE ADMINISTRATIONBENJAMIN BURROWS, M.D., ALBERT H. NIDEN, M.D., WILLIAM R. BARCLAY, M.D.BENJAMIN BURROWS, M.D.Search for more papers by this author, ALBERT H. NIDEN, M.D.Search for more papers by this author, WILLIAM R. BARCLAY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-52-4-858 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe syndrome of goiter and/or myxedema due to administration of iodide preparations has been reported in more than 30 cases since 1945.1-14 Despite these observations, most of them single case reports, the association of thyroid abnormalities and iodide therapy is not widely recognized.It is generally accepted that the suppression of function and involution of the thyroid gland of Graves' disease from iodide therapy15, 16are peculiar to that disorder and have no counterpart when iodides are administered to a euthyroid subject. The well documented suppression of thyroidal organic binding of iodine induced by large doses of iodide17, 18, 19...Bibliography1. 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WolffChaikoffGoldbergMeier JILRCJR: The temporary nature of the inhibitory action of excess iodide on organic synthesis in the normal thyroid, Endocrinology 45: 504, 1949. CrossrefMedlineGoogle Scholar21. DanowskiJohnstonGreenman RSSYJH: Alterations in serum iodine fractions induced by the administration of inorganic iodide in massive doses, J. Clin. Endocrinol. 10: 519, 1950. CrossrefGoogle Scholar22. ChildsKeatingRallWilliamsPower DSFRJEMMMH: The effect of varying quantities of inorganic iodide (carrier) on the urinary excretion and thyroidal accumulation of radioiodine in exophthalmic goiter, J. Clin. Investigation 29: 726, 1950. CrossrefMedlineGoogle Scholar23. GreerDeGroot MALJ: The effect of stable iodine on thyroid secretion in man, Metabolism 5: 682, 1956. MedlineGoogle Scholar24. Solomon DH: Factors affecting the fractional rate of release of radioiodine from the thyroid gland in man, Metabolism 5: 667, 1956. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication June 30, 1959.From the Department of Medicine, The University of Chicago, Chicago, Illinois.Requests for reprints should be addressed to Benjamin Burrows, M.D., University of Chicago Clinics, 950 East Fifty-ninth Street, Chicago 37, Illinois. 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