tbuckley/cabot-search huggingface dataset:
Inheritance of Mitral Valve Prolapse: Effect of Age and Sex on Gene Expression
Authors: RICHARD B. DEVEREUX
Journal: Annals of Internal Medicine (1982)

To ascertain if mitral valve prolapse is inherited we studied 45 probands and 179 first-degree relatives. Echocardiographic mitral prolapse was present in 54 of 179 first-degree relatives (30%); at least one first-degree relative was affected in 29 families, including members of two generations in 23 families. The number of affected persons in the 54 sibships fell within the range predicted for autosomal dominant inheritance. The familial prevalence of prolapse was similar whether or not the proband had characteristic symptoms, auscultatory abnormalities, electrocardiographic findings, thoracic bony abnormalities, or coexistent heart disease. Mitral prolapse occurred in 37 of 90 women (41%) but 17 of 89 men (19%; p < 0.005), and in 51 of 143 adults (35%) but only 3 of 36 children aged 1 to 15 (p < 0.005). Mitral valve prolapse is an inherited autosomal dominant condition irrespective of clinical findings, and the mitral prolapse gene shows age and sex dependent expression. Mitral valve prolapse appears to be the commonest mendelian cardiovascular abnormality in humans.
Hypertension in Pregnancy and Later Cardiovascular Risk
Authors: Pål R. Romundstad, Elisabeth B. Magnussen, George Davey Smith, Lars J. Vatten
Journal: Circulation (2010)

Background— Preeclampsia and gestational hypertension are associated with increased risk for cardiovascular disease later in life. We have assessed whether the effect can be attributed to factors that operate in pregnancy or to prepregnancy risk factors that are shared by both disorders. Methods and Results— Longitudinal data from 2 consecutive waves of a Norwegian population-based study (the Nord-Trøndelag Health Study [HUNT]) were combined with data from the Medical Birth Registry of Norway. Among 24 865 women who had participated in both HUNT 1 and 2, we indentified 3225 women with a singleton birth between the 2 studies who had standardized measurements of blood pressure, serum lipids, and body mass index. The crude results showed that women who experienced preeclampsia or gestational hypertension in pregnancy had substantially higher levels of body mass index and systolic and diastolic blood pressures and unfavorable lipids compared with other women. However, after adjustment for prepregnancy measurements, the difference in body mass index was attenuated by &gt;65%, and the difference in blood pressure was attenuated by ≈50%. In relation to high-density lipoprotein cholesterol and triglycerides, differences between the groups were attenuated by 40% and 72%, respectively. Conclusions— These results suggest that the positive association of preeclampsia and gestational hypertension with postpregnancy cardiovascular risk factors may be due largely to shared prepregnancy risk factors rather than reflecting a direct influence of the hypertensive disorder in pregnancy.
Comment on: Lin et al. Long-Term Changes in Adiposity and Glycemic Control Are Associated With Past Adenovirus Infection. Diabetes Care 2013;36:701–707
Authors: Tomohide Yamada, Kazuo Hara, Takashi Kadowaki
Journal: Diabetes Care (2013)

We read with great interest the article by Lin et al. (1), who performed a cohort study and concluded that Ad36 seropositivity was associated with greater adiposity and less deterioration of glycemic control. They reported that seropositive individuals had a higher percentage of body fat coupled with lower fasting insulin levels. Their results are considered important because of the long follow-up period of the study, and the findings help us gain a better understanding of whether this virus …
The AMA Dollar
Authors: I. Wilson Gittleman
Journal: JAMA (1966)

<h3>To the Editor:—</h3> I am truly appalled at the mention of the AMA dues being raised again—and this time $25. It has occurred to me every time I openThe Journalto ask you how much it costs in additional printing expense to put the colored art reproduction or pathology specimen on the cover. And how much would this reduce the anticipated raise, if omitted? What service is being filled by these large artistic masterpieces? What other medical journal has reproductions such as these, and every week, at that? But of course no other society has had such steady membership-dues increases and in such large increments.
O114 RESULTS OF THE PHASE 2 STUDY M12-999: INTERFERON-FREE REGIMEN OF ABT-450/R/ABT-267 + ABT-333 + RIBAVIRIN IN LIVER TRANSPLANT RECIPIENTS WITH RECURRENT HCV GENOTYPE 1 INFECTION
Authors: P. Kwo, P. Mantry, E. Coakley, H. Te, H. Vargas, R. Brown, F. Gordon, J. Levitsky, N. Terrault, J. Burton, W. Xie, C. Setze, P. Badri, R.A. Vilchez, X. Forns
Journal: Journal of Hepatology (2014)
Abstract 2433: Eradication of established pancreatic tumors in mice by engagement of extra-tumoral human T cells with BiTE antibody MT110
Authors: Matthias Friedrich, Daniela Drache, Maria Amann, Susanne Filusch, Markus Voelkel, Oliver Thomas, Patrick A. Baeuerle, Benno Rattel
Journal: Cancer Research (2010)

Abstract MT110 is a T cell-engaging, EpCAM/CD3-bispecific BiTE antibody that is currently being tested in a dose-escalating clinical phase 1 study in gastrointestinal and lung cancer patients. MT110 has shown high potency of redirected lysis in cell-based assays at picomolar concentrations. Previous studies with MT110 have shown that subcutaneous (s.c.) pancreatic tumor formation can be delayed in NOD/SCID mice when human tumor cells are mixed prior to inoculation with human peripheral blood mononuclear cells (PBMC) at a ratio of 1:2. Likewise, MT110 is able to eradicate s.c.-implanted human metastatic tissue (&amp;lt;80 mm3) freshly dissected from ovarian cancer patients. In this model, the only source of effector cells were tumor-resident T cells from the respective patient sample. Here we have further explored in a new NOD/SCID mouse model the anti-tumor activity of MT110 on established s.c. tumors derived from the human pancreas cancer cell line Aspc1. Effector cells, human peripheral T cells, were expanded ex vivo in the presence of T cell mitogens. NOD/SCID mice were reconstituted with human T cells by intraperitoneal (i.p.) injection once the tumors had reached at least 150 mm3. Following adoptive transfer, human T cells were detected in the peripheral blood of mice for up to 6 days. Tumor-bearing mice were treated for 28 days with 350 µg MT110/kg (approx. 3 µg MT110/mouse) by either daily i.v. bolus injection or continuous i.p. infusion using Alzet osmotic pumps. With the onset of MT110 treatment by either route, Aspc1 tumors of approx. 300 mm3 started to shrink. After two weeks, tumors in all MT110-treated mice were less than 50 mm3, and 3 out of animals 11animals were completely free of tumor. In contrast, all tumors in vehicle control mice had reached an average size of 500 mm3 during this period. At the end of the study after 8 weeks and 2.5 weeks after last dosing, 3 out of 11 animals remained tumor-free. Among the remaining eight tumor-bearing animals, all showed tumor regression 38-40 days after start of the study. Our data show that established tumors grown can be eradicated by BiTE antibody MT110 by engaging initially extra-tumoral human T cells. This indicates that cancer therapy with MT110 and other BiTE antibodies in development may not solely rely on tumor-resident T cells. Moreover, MT110 may have activity against pancreatic cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2433.
Bad Outcomes of Questionable Medical Decisions
Authors: Kenneth M. Kessler
Journal: Annals of Internal Medicine (2003)

Letters18 March 2003Bad Outcomes of Questionable Medical DecisionsKenneth M. Kessler, MDKenneth M. Kessler, MDUniversity of Miami School of Medicine; Miami, FL 33101 (Kessler)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-138-6-200303180-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Questionable clinical decisions, such as those described in the article by Hofer and Hayward (1), represent preventable medical errors whenever substantially better options are available, independent of outcome or cascade iatrogenesis. When the outcome is removed from the equation, the decision-making process can be explored without hindsight bias. On the eve of the ill-fated pericardiocentesis in Hofer and Hayward's article, the patient was stable and improved. Minoxidil therapy and anticoagulation were to be discontinued. In the absence of tachycardia, jugular venous distention, and pulsus paradoxus, the patient was not in tamponade (2). The size of an effusion ...References1. Hofer TP, Hayward RA. Are bad outcomes from questionable clinical decisions preventable medical errors? A case of cascade iatrogenesis. Ann Intern Med. 2002;137:327-33. [PMID: 12204016] LinkGoogle Scholar2. Shebetai R. Diseases of the pericardium.. In: Alexander RW, Schlant RC, Furster V, eds. The Heart. 9th ed. New York: McGraw-Hill; 1998:2169-203. Google Scholar Author, Article, and Disclosure InformationAffiliations: University of Miami School of Medicine; Miami, FL 33101 (Kessler) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAre Bad Outcomes from Questionable Clinical Decisions Preventable Medical Errors? A Case of Cascade Iatrogenesis Timothy P. Hofer and Rodney A. Hayward Are Bad Outcomes from Questionable Clinical Decisions Preventable Medical Errors? A Case of Cascade Iatrogenesis Timothy P. Hofer and Rodney A. Hayward Bad Outcomes of Questionable Medical Decisions Elizabeth Nilson Bad Outcomes of Questionable Medical Decisions William B. Weeks and James P. Bagian Bad Outcomes of Questionable Medical Decisions Timothy P. Hofer and Rodney A. Hayward Metrics 18 March 2003Volume 138, Issue 6Page: 519KeywordsEchocardiographyHemodynamicsIntensive care unitsTachycardia ePublished: 18 March 2003 Issue Published: 18 March 2003 CopyrightCopyright © 2003 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Yttrium-90, a new beta emitter for prevention of post angioplasty restenosis: Tissue dosimetry and importance of intraarterial centering
Authors: Vitali Verin, Youri Popowski, Phillip Urban, Phillip Nouet, Michel Rouzaud, Michael Schwager, John M. Kurtz, Wilhelm Rutishauser
Journal: Journal of the American College of Cardiology (1996)
A morphological study of macrophage and synovial cell interactions with hydroxyapatite crystals.
Authors: R S Hirsch, K Smith, B Vernon-Roberts
Journal: Annals of the Rheumatic Diseases (1985)

Hydroxyapatite crystals have been found in synovial fluids and periarticular spaces in association with osteoarthritis. This study examined the morphology of the interaction of macrophages and synovial cells with hydroxyapatite in order to determine the fate of hydroxyapatite over an extended culture period. Mouse peritoneal macrophages and bovine synovial cells were grown as monolayers. The morphology of the interaction between hydroxyapatite crystals (HAC) and these cells was studied by light microscopy, transmission and scanning electron microscopy for up to 14 days. Phagocytosis of HAC, phagosome formation, and concentration of crystal aggregates around the cells began within four minutes of their addition to the cultures. Phagocytosis and cellular aggregation continued after this time. HAC caused minimal cellular disruption despite the uptake of large amounts of crystalline material and significant cellular enlargement. HAC remained within cells for the duration of the study without any apparent dissolution by the cells. Whether macrophages are stimulated to produce interleukin I as a result of HAC uptake is currently under investigation.
Interaction of the anticoagulant drug warfarin and its metabolites with human plasma albumin
Authors: Robert A. O'Reilly
Journal: Journal of Clinical Investigation (1969)

The interaction of the anticoagulant drug warfarin and its metabolites with human plasma albumin was studied by equilibrium dialysis. A 20-fold variation of buffer ionic strength (0.017-0.340) caused no significant change in the warfarin association constant. But the binding strength rose significantly as the pH was increased from 6.0 to 9.0 and then declined at pH 10.0. The 6-, 7-, and 8-hydroxywarfarin metabolites showed a 7- to 23-fold reduction in binding strength at pH 10.0. These data indicate that the molecular basis of the interaction is nonelectrostatic and that the introduction of polar hydroxyl groups on the coumarin nucleus by metabolism reduces its hydrophobic binding surface. The interaction was markedly exothermic and showed a positive entropy (increased molecular disorder), which suggests cooperative hydrogen and hydrophobic bonding as the molecular basis for the binding of warfarin to albumin. The marked albumin binding and nonpolar character of warfarin explains the respective absence and presence of the unchanged drug in urine and plasma of warfarintreated patients, while the more polar character and lesser albumin binding of the metabolites probably determines their absence in plasma and presence in urine. The relatively marked binding to albumin of the 4'-hydroxywarfarin metabolite suggests that it may occur in the plasma of warfarin-treated patients. The data suggest that a direct correlation exists between the interaction of warfarin with plasma albumin and the interaction with the warfarin receptor site.
Acute Myocardial Infarction in Pregnancy
Authors: Andra H. James, Margaret G. Jamison, Mimi S. Biswas, Leo R. Brancazio, Geeta K. Swamy, Evan R. Myers
Journal: Circulation (2006)

The purpose of this study was to determine the incidence, mortality, and risk factors for pregnancy-related acute myocardial infarction in the United States.The Nationwide Inpatient Sample for the years 2000 to 2002 was queried for all pregnancy-related discharges. A total of 859 discharges included a diagnosis of acute myocardial infarction, for a rate of 6.2 (95% confidence interval [CI] 3.0 to 9.4) per 100,000 deliveries. Among these, there were 44 deaths, for a case fatality rate of 5.1%. The odds of acute myocardial infarction were 30-fold higher for women aged 40 years and older than for women <20 years of age. Single independent variables that were statistically and clinically significant, including age, race, and certain medical conditions and obstetric complications, were entered into a multivariable logistic regression model. Hypertension (odds ratio [OR] 21.7, 95% CI 6.8 to 69.1), thrombophilia (OR 25.6, 95% CI 9.2 to 71.2), diabetes mellitus (OR 3.6, 95% CI 1.5 to 8.3), smoking (OR 8.4, 95% CI 5.4 to 12.9), transfusion (OR 5.1, 95% CI 2.0 to 12.7), postpartum infection (OR 3.2, 95% CI 1.2 to 10.1), and age 30 years and older remained as significant risk factors for pregnancy-related acute myocardial infarction. Black race was eliminated as a risk factor in the multivariable analysis, which suggests that the increased incidence among black women is explained by an increased prevalence of other cardiovascular risk factors.Although acute myocardial infarction is a rare event in women of reproductive age, pregnancy increases the risk 3- to 4-fold. Certain medical conditions and complications of pregnancy increase the risk further and are potentially modifiable risk factors.
Cerebral venous thrombosis and subarachnoid haemorrhage in users of oral contraceptives.
Authors: E Chilvers, P Rudge
Journal: BMJ (1986)

view of our findings, however, serial measurements for individual patients should always be taken using the same model, even if it is impracticable to use the same instrument.We thank the staff, parents, and pupils of St Mary's Primary School, Greenock, for their willing help, Dr G D Murray for statistical advice, and Astra Pharmaceuticals Ltd for providing the peak flow meters.
Pediatric Clinical Problem Solving
Authors: Laurence Finberg
Journal: JAMA (1982)

The author has written this book specifically for use by medical students and residents in pediatrics to guide them in the process of solving clinical problems. To a significant extent I believe he succeeds. The writing style is direct and clear if a bit prolix and occasionally redundant. The author tries to abstract the process of problem solving from the content of medical knowledge. In so doing he unintentionally demonstrates how difficult this is. His technique is to use examples of childhood illnesses with the problem solving centering around the presenting complaint, eg, a child with a seizure, a child with abdominal pain, coma, fever, etc. When he is dealing with a problem of an infectious or immunologic nature, the logic is crisp, the lines of inquiry suggested pertinent and creative, and the solution to the problems incisive. On the other hand, when dealing with metabolic and physiological problems, the
Are there two kinds of ward round?
Authors: T. B Brewin
Journal: BMJ (1982)

Are there two kinds of ward round? THURSTAN B BREWINThe scene could be any medical or surgical ward anywhere.Discussion of an interesting diagnostic problem (out of earshot of the patients) is just coming to an end ... CONSULTANT: Are we agreed then ?The diagnosis is wide open, and we take no further action until we have the results of the various x-rays and so on. . . .Now, it is getting late, who do we see next?
Detection of pericardial metastases by cross-section echocardiography.
Authors: P A Chandraratna, W S Aronow
Journal: Circulation (1981)

Cross-sectional echocardiography was performed on 69 patients with pericardial effusion. The etiology of the pericardial effusion was malignant infiltration of the pericardium in nine patients; chronic renal failure in 10; postcardiac surgery in 31; viral pericarditis in three; tuberculous pericarditis in two; and undetermined in 14. Seven of the nine patients with pericardial metastases were noted to have irregular cauliflower-like masses protruding from the pericardium and the epicardium into the echo-free space of the pericardial effusion. These masses demonstrated a to-and-fro motion within the pericardial space during ventricular systole. The presence of pericardial metastases was confirmed at operation in four cases and the three others had intrathoracic or colonic malignancy with widespread metastases. None of the patients without pericardial metastasis showed the characteristic abnormality seen in patients with pericardial metastases. Six patients had dense linear echoes connecting the pericardium and epicardium that probably represented adhesions (confirmation at surgery in one, and confirmation at autopsy in another), with an appearance that was different from that seen in pericardial metastases. We conclude that cross-sectional echocardiography may be useful for detecting pericardial metastases.
Color Atlas of Clinical Neurology
Authors: Michael P. Alexander
Journal: JAMA (1984)

This book is one of a series of color atlases of medicine. With minimal text and 603 illustrations the author attempts to help senior students to understand the significance of [neurologic] signs and their investigation. The author acknowledges the necessity of omissions and sweeping generalizations in order to present as much material as possible within the format of this series. He is also limited to topics and diseases that lend themselves to illustration and photography.  Given the modest goals and limiting format, it might be expected that the book would focus on common diseases and typical clinical presentations. These prototypical clinical situations could be augmented with schematic illustrations when appropriate, by up-to-date radiological methodology and by gross neuropathology. There are, in fact, several clear and useful lessons that display this optimal use of the book's format: the summary of the aneurysms of the posterior communicating artery and of the cavernous
Cancer: Principles and Practice of Oncology
Authors: Walter G. Gunn
Journal: JAMA (1990)

The third edition of DeVita, Hellman, and Rosenberg's by now classic text on cancer preserves the multimodal, integrated approach to clinical evaluation and treatment of that disease. The editors see to that approach by close supervision of the 66 individual chapters, each of which is written by one or more recognized experts. For a multiauthored text to be successful, information presented must be cogent and up-to-date. For the busy practitioner, it helps to read a scientific style that is lucid, if not graceful, succinct but not overwhelming. Most of us have tried to look up specific material and find information that will help us deal with daily clinical problems. Too often a comprehensive text leaves us no better off than we began—bogged down with excess cumbersome detail and without the help we had hoped to find. Happily, such is not the case with this text, nor was it a problem
Regression of lymphoproliferative disorder after treatment for hepatitis C virus infection in a patient with partial trisomy 3, Bcl-2 overexpression, and type II cryoglobulinemia
Authors: Milvia Casato, Cristina Mecucci, Vincent Agnello, Massimo Fiorilli, Glenn B. Knight, Caterina Matteucci, Lei Gao, Jonathan Kay
Journal: Blood (2002)
The S. Typhimurium Effector SopE Induces Caspase-1 Activation in Stromal Cells to Initiate Gut Inflammation
Authors: Andreas J. Müller, Claudia Hoffmann, Marlies Galle, Aeke Van Den Broeke, Mathias Heikenwalder, Laura Falter, Benjamin Misselwitz, Marcus Kremer, Rudi Beyaert, Wolf-Dietrich Hardt
Journal: Cell Host & Microbe (2009)
Screening for Ovarian Cancer
Authors: Roger A. Renfrew
Journal: Annals of Internal Medicine (1995)

Letters15 January 1995Screening for Ovarian CancerRoger A. RenfrewRoger A. RenfrewRedington Medical Associates, Skowhegan, ME 04976. Massachusetts General Hospital, Boston, MA 02114.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-122-2-199501150-00017 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The clinical guideline and review article on screening for ovarian cancer are concise, clear statements about this particular issue [1, 2]. As a practicing clinician, I appreciate the effort to provide guidance for a rational clinical approach to screening testing.One gray area related to this problem is the need for pelvic examinations in healthy, asymptomatic, previously screened (for cervical cancer) women between Papanicolaou tests. I generally do Papanicolaou tests every 3 years in my patients after establishing two or three normal test results within a year. How often pelvic examinations need to be done exemplifies the ...References1. Carlson KJ, Skates SJ, Singer DE. Screening for ovarian cancer. Ann Intern Med. 1994; 121:124-32. Google Scholar2. American College of Physicians. Screening for ovarian cancer: recommendations and rationale. Ann Intern Med. 1994; 121:141-2. Google Scholar Author, Article, and Disclosure InformationAffiliations: Redington Medical Associates, Skowhegan, ME 04976. Massachusetts General Hospital, Boston, MA 02114. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 January 1995Volume 122, Issue 2Page: 155KeywordsCancer screeningCervical cancerOvarian cancer Issue Published: 15 January 1995 Copyright & PermissionsCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...