CLINICAL EXPERIENCE WITH SYMPATHETIC BLOCKING AGENTS IN PERIPHERAL VASCULAR DISEASE
Authors: Marvin Moser, Andrew G. Prandoni, James A. Orbison, Thomas W. Mattingly
Journal: Annals of Internal Medicine (1953)

Article1 June 1953CLINICAL EXPERIENCE WITH SYMPATHETIC BLOCKING AGENTS IN PERIPHERAL VASCULAR DISEASEMARVIN MOSER, ANDREW G. PRANDONI, M.D., JAMES A. ORBISON, THOMAS W. MATTINGLYMARVIN MOSERSearch for more papers by this author, ANDREW G. PRANDONI, M.D.Search for more papers by this author, JAMES A. ORBISONSearch for more papers by this author, THOMAS W. MATTINGLYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-6-1245 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the last five years numerous agents capable of blocking the sympathetic nervous system have been utilized in the study and treatment of peripheral vascular disease.1-8Although these agents act in different ways and at different sites, the objective—a partial or complete blockade of the sympathetic nervous system—is the same. This "sympatholytic" effect may be produced by a substance which interferes with sympathetic vasoconstrictor reflexes through a central site of action,9, 10or peripherally, by a drug which blocks sympathetic nerve activity at the neuroeffector junction11, 12(figure 1). In addition to inhibiting the response to sympathetic nerve stimulation, an...Bibliography1. BerryCampbellLyonsMoeSutler RLKNRHGKMR: The use of tetraethylammonium in peripheral vascular disease and causalgic states. A new method for producing blockade of the autonomic ganglia, Surgery 20: 525, 1946. MedlineGoogle Scholar2. HooblerMaltonBallantineCohenNelighPeetLyons SWSDHTSRBMMRH: Studies on vasomotor tone. I. The effect of the tetraethylammonium ion on the peripheral blood flow of normal subjects, J. Clin. Investigation 28: 638, 1949. CrossrefGoogle Scholar3. 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MoserPrandoni MAG: Personal observations. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication January 30, 1953.From the Cardiovascular-Renal Section, Medical Service, Walter Reed Army Hospital, Washington, D. C.†Supplied by Smith, Kline and French Laboratories, Philadelphia, Pa.‡Supplied by E. R. Squibb Co., New York, N. Y. 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