tbuckley/cabot-search huggingface dataset:
Correction: Pasteurella new species
Authors: DIETER W. GUMP
Journal: Annals of Internal Medicine (1972)

Letters, Comments, and Corrections1 June 1972Correction: Pasteurella new speciesDIETER W. GUMP, M.D.DIETER W. GUMP, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-6-1047_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: I wish to point out two errors in the last two lines on page 277 and the first line of page 278 of my paper that was published in the February issue. The sentence with these two errors reads, "Pasteurella hemolyticaproduces hemolysis on blood agar and is indole positive:P. new speciesis indole negative and does not produce any hemolysis on blood agar." This sentence should read, "Pasteurella hemolyticaproduces hemolysis on blood agar and is indole negative:P. newspecies is indole positive and does not produce any hemolysis on blood agar."...Reference1. GUMPHOLDEN DR: Endocarditis caused by new species of Pasteurella. Ann Intern Med 76:275-278, 1972 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine College of Medicine The University of Vermont Burlington, Vt. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 June 1972Volume 76, Issue 6Page: 1047-1047KeywordsBlood Issue Published: 1 June 1972 PDF downloadLoading ...
Nadolol: A New β-Adrenoceptor Antagonist
Authors: Jan Koch-Weser, William H. Frishman
Journal: New England Journal of Medicine (1981)

NADOLOL (Corgard) is a β-adrenoceptor antagonist that was released late in 1979 for clinical use in the United States (Fig. 1). It is the third oral systemic β-blocker to be approved by the Food and Drug Administration for the treatment of hypertension, and the second to be approved for angina pectoris. Before the introduction of nadolol, propranolol was available for the treatment of systemic hypertension, angina pectoris, and adrenergically induced cardiac arrhythmias. Metoprolol, a β1-selective adrenergic blocker, was approved only for the treatment of hypertension. Nadolol, like propranolol, is a nonselective β-adrenergic blocker. However, it is distinguished from . . .
An unusual complication of appendicitis
Authors: S L Mackie
Journal: Annals of the Rheumatic Diseases (2004)

A 32 year old man presented with a 3 day history of fever, central abdominal pain, and frequent loose bowel motions without blood or mucus. The pain had recently shifted to his right iliac fossa. He had previously been well and he was receiving no regular drugs. On examination he was systemically well, but rebound tenderness was noted in the right iliac fossa, and C reactive protein (CRP) was raised (78 mg/l, reference range <10). A diagnosis of acute appendicitis was made and he underwent appendicectomy. Histology disclosed serosal congestion with …
Identification of Protein Disulfide Isomerase as a Cardiomyocyte Survival Factor in Ischemic Cardiomyopathy
Authors: Anna Severino, Mara Campioni, Stefania Straino, Fadi N. Salloum, Nina Schmidt, Ulrike Herbrand, Stilla Frede, Gabriele Toietta, Giuliana Di Rocco, Rossana Bussani, Furio Silvestri, Maddalena Piro, Giovanna Liuzzo, Luigi M. Biasucci, Pasquale Mellone, Florinda Feroce, Maurizio Capogrossi, Feliciano Baldi, Joachim Fandrey, Michael Ehrmann, Filippo Crea, Antonio Abbate, Alfonso Baldi
Journal: Journal of the American College of Cardiology (2007)
Cases of Obstruction of the Small Intestine by Gall-Stones
Authors: W. J. Cant
Journal: BMJ (1897)

During the next two days the temperature did not exceed 99.5°O n the morning of May 14th it was 990, but there was a very severe urticarial rash all over the body.The irritation was intense.In the afternoon the patient had a rigor, fol- lowed by acute pain in the abdomen and sickness.The temperature was 1040, pulse 120.Three 6-gr.doses of quinine were given at two hours' interval.
PHENOTHIAZINE EXCRETION IN CHRONIC SCHIZOPHRENICS
Authors: EUGENE M. CAFFEY, IRENE S. FORREST, THOMAS V. FRANK, C. JAMES KLETT
Journal: American Journal of Psychiatry (1963)

A study of the effects of discontinuing or reducing maintenance medication in chronic schizophrenic men provided an opportunity to evaluate the clinical usefulness of one of the rapid semi-quantitative urine tests (FPN). The rate of excretion of chlorpromazine and thioridazine after placebos had been substituted was determined and the effects of intermittent administration of drugs were observed. The FPN test performed as expected, also providing some interesting information about patients' drug taking behavior. The lower colorimetric readings obtained with thioridazine were most interesting but do not preclude the use of the test done with strict attention to detail in a clinical setting. As the FPN test is a qualitative procedure, its semi-quantitative potential as used in this study should be considered an approximation yielding usable comparative results.
Induction of midbrain dopaminergic neurons by Sonic hedgehog
Authors: Mary Hynes, Jeffery A. Porter, Chin Chiang, David Chang, Marc Tessier-Lavigne, Philip A. Beachy, Arnon Rosenthal
Journal: Neuron (1995)

Midbrain dopaminergic neurons, whose loss in adults results in Parkinson's disease, can be specified during embryonic development by a contact-dependent signal from floor plate cells. Here we show that the amino-terminal product of Sonic hedgehog autoproteolysis (SHH-N), an inductive signal expressed by floor plate cells, can induce dopaminergic neurons in vitro. We show further that manipulations to increase the activity of cyclic AMP-dependent protein kinase A, which is known to antagonize hedgehog signaling, can block dopaminergic neuron induction by floor plate cells. Our results and those of other studies indicate that SHH-N can function in a dose-dependent manner to induce different cell types within the neural tube. Our results also provide the basis for a potential cell transplantation therapy for Parkinson's disease.
Peak expiratory flow in youths with varying cigarette smoking habits.
Authors: C I Backhouse
Journal: BMJ (1975)

Measurements of peak expiratory flow (P.E.F.) were done on 195 boys arriving at a detention centre, and again eight weeks later at the time of their discharge. During this time they took much physical exercise, and cigarette smoking and drug taking were not permitted. At the initial assessment there was an impairment of P.E.F. inversely proportional to the amount of cigarettes smoked which was statistically significant. There was a significant improvement in P.E.F. between reception and discharge in all groups of boys with varying smoking habits, all groups except the heavy smokers achieving near normal results after eight weeks. The heavier smokers improved more than the non-smokers or light smokers, but this difference was not statistically significant. Suggested reasons for this improvement are discussed.
Emergency Esophageal Electrode
Authors: Henry L. Green
Journal: JAMA (1966)

<h3>To the Editor:—</h3> Identification of P waves is one of the most important steps in the diagnosis of cardiac arrhythmias. The esophageal lead is well established as a practical tool for this purpose. Should one not be available, I have found that a satisfactory substitute can quickly be assembled. A small-caliber feeding tube is selected. A length of stainless-steel suture material is passed through the tube. The suture is tied to the lower end of the feeding tube with a running clove hitch and its free end tucked under the knot. This type of tie provides adequate area for contact with the esophagus. The other end of the suture is wound around the chest lead of the patient cable and secured with a hemostat. The feeding tube is then coated with ordinary surgical lubricant and passed in the usual manner.
Doppler and two-dimensional echocardiographic observations of systolic anterior motion of the mitral valve in d-transposition of the great arteries: An explanation of the left ventricular outflow tract gradient
Authors: Eugenio Moro, Folkert J. Ten Cate, Conny Tirtaman, James J. Leonard, Jos Roelandt
Journal: Journal of the American College of Cardiology (1986)
Origin and Speciation of Haplochromine Fishes in East African Crater Lakes Investigated by the Analysis of Their mtDNA, Mhc Genes, and SINEs
Authors: Akie Sato, Naoko Takezaki, Herbert Tichy, Felipe Figueroa, Werner E. Mayer, Jan Klein
Journal: Molecular Biology and Evolution (2003)

The Western Branch of the East African Great Rift Valley is pocketed with craters of extinct or dormant volcanoes. Many of the craters are filled with water, and the lakes are inhabited by fishes. The objective of the present study was to determine the amount and nature of genetic variation in haplochromine fishes inhabiting two of these crater lakes, Lake Lutoto and Lake Nshere, and to use this information to infer the origin and history of the two populations. To this end, sequences of mitochondrial (mt) DNA control region, exon 2 of major histocompatibility complex (Mhc) class II B genes, and short interspersed elements (SINEs) were analyzed. The results indicate that the Lake Nshere and Lake Lutoto fishes originated from different but related large founding populations derived from the Kazinga Channel, which connects Lake Edward and Lake George. Some of the genetic polymorphism that existed in the ancestral populations was lost in the populations of the two lakes. The polymorphism that has been retained has persisted for some 50,000 generations (years). During this time, new mutations arose and became fixed in each of the two populations in the mtDNA, giving rise to sets of diagnostic substitutions. Each population evolved in isolation after the colonization of the lakes less than 50,000 years ago. There appears to be no population structure within the crater lake fishes, and their present effective population sizes are in the order of 104 to 105 individuals. Comparisons with the endemic haplochromine species of Lake Victoria reveal interesting parallels, as well as differences, which may help to understand the nature of the speciation process.
LIVER DAMAGE AND URINARY EXCRETION OF SULFATE IN RATS FED l-CYSTINE, dl-METHIONINE, AND CYSTEIC ACID
Authors: David P. Earle, Forrest E. Kendall
Journal: The Journal of Experimental Medicine (1942)

1. Rats fed l-cystine at excessive levels excrete large amounts of sulfate sulfur in the urine and develop liver necrosis and cirrhosis. 2. Rats fed dl-methionine at excessive levels excrete large amounts of sulfate sulfur, but do not develop liver necrosis and cirrhosis. 3. Rats fed cysteic acid at high levels excrete relatively small amounts of sulfate, but do develop liver necrosis and cirrhosis. 4. In conclusion, there is no apparent correlation between the amount of sulfate formed and the development of liver damage in rats fed l-cystine, dl-methionine, and cysteic acids.
Studies on the blood fibrinolytic enzyme system of patients with cutaneous vasculitis
Authors: NAOTIKA TOKI, TAKUSO YAMURA
Journal: British Journal of Dermatology (1980)

The fibrinolytic enzyme system in thirty-two patients suffering from cutaneous vasculitis was investigated. In five of seven patients with Behçet's disease and in five of thirteen patients with erythema nodosum a significant elongation of euglobulin lysis time was observed. On the other hand, in two patients with allergic vasculitis, a significant shortening of euglobulin lysis time was noticed. In the present study, factors responsible for the change of euglobulin lysis time were sought. It was confirmed that the significant elongation of euglobulin lysis time in patients with erythema nodosum was based on an increase of fibrinogen content in the euglobulin fraction. On the other hand, it was speculated that the significant elongation of euglobulin lysis time in patients with Behçet's disease might be due to an increase of antiactivators in the patients' plasma. In the present study, the authors further investigated the status of this antiactivator which is increased in plasma of patients with Behçet's disease, and proposed the possibility that the increased antiactivator might consist of at least two types of antiactivators, one of which is considered to be alpha 2-plasmin inhibitor.
Gingival Biopsy in Thrombotic Thrombocytopenic Purpura
Authors: ANITA GOODMAN
Journal: Annals of Internal Medicine (1978)

Gingival biopsy has been advocated as a readily available, safe, rapid histologic confirmation of the clinical diagnosis of thrombotic thrombocytopenic purpura. Eighteen gingival biopsies from 16 patients with proven thrombotic thrombocytopenic purpura were reviewed. Seven (39%) showed characteristic histologic changes: [1] subendothelial hyalinelike deposits; [2] intraluminal deposits; [3] lack of inflammatory change in vessels and stroma. To assess specificity, gingival sections from 154 patients with oral pathology only and from 50 unselected autopsies were reviewed: 10% to 20% of biopsies from patients with oral pathology only (primarily inflammation) and three of 50 autopsy specimens showed occasional intraluminal deposits but no subendothelial deposits. In addition, other histologic features permitted them to be distinguished from thrombotic thrombocytopenic purpura. We conclude that gingival biopsy in thrombotic thrombocytopenic purpura, although helpful in confirming the diagnosis, is less often positive than has been suggested. Biopsy of grossly inflamed gingiva should be avoided.
Echophonocardiographic study of the initial low frequency component of the first heart sound
Authors: Yoshiyuki Hada, Katsu Takenaka, Toshiyuki Ishimitsu, Tsuneo Yamaguchi, Keiko Amano, Hisako Takahashi, Reiko Takikawa, Tsuguya Sakamoto
Journal: Journal of the American College of Cardiology (1983)
Suicide Runs in Families With ADHD
Authors: Anita Slomski
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tips for a Physician in Getting the Right Job, Part XXI
Authors: Jay A. Harolds
Journal: Clinical Nuclear Medicine (2015)

Those physicians who have excellent job prospects, and preferably have more than one offer, may wish to try to negotiate better terms for their employment contract than was initially offered. However, any negotiation must be done in a friendly, polite, and professional manner. This article gives many tips regarding contract negotiations. However, the employment contract should be discussed with the job seeker's family and attorney before signing it.
The cultural capital of the moralist and the scientist
Authors: Min Ju Kang, Michael Glassman
Journal: Behavioral and Brain Sciences (2010)

Abstract In this commentary we explore Knobe's ideas of moral judgments leading to moral intuitions in the context of the moral thought and moral action debate. We suggest that Knobe's primary moral judgment and the setting of a continuum with a default point is in essence a form of cultural capital, different from moral action, which is more akin to social capital.
Transcutaneous oxygen tension and toe blood pressure as predictors for outcome of diabetic foot ulcers.
Authors: M Kalani, K Brismar, B Fagrell, J Ostergren, G Jörneskog
Journal: Diabetes Care (1999)

OBJECTIVE: The present study was undertaken to compare the predictive values of transcutaneous oxygen tension (TcPO2) and toe blood pressure (TBP) measurements for ulcer healing in patients with diabetes and chronic foot ulcers. RESEARCH DESIGN AND METHODS: Investigated prospectively were 50 diabetic patients (37 men) with chronic foot ulcers. The age was 61 +/- 12 (mean +/- SD), and the diabetes duration was 26 +/- 14 years. TBP (mmHg) was measured in dig I and TcPO2 (mmHg) at the dorsum of the foot. Ulcer healing was continuously evaluated by measuring the ulcer area every 4-6 weeks. After a follow-up time of 12 months, the patients were divided into three groups according to clinical outcome: healed with intact skin, improved ulcer healing, or impaired ulcer healing. RESULTS: Of the 13 patients who deteriorated, 11 had TcPO2 &amp;lt; 25 mmHg, while 34 of the 37 patients who improved had TcPO2 &amp;gt; or = 25 mmHg. The sensitivity and specificity for TcPO2 were 85 and 92%, respectively, when a cutoff level of 25 mmHg was used for determination of outcome of ulcer healing (healing or nonhealing). The corresponding values for TBP at 30 mmHg were 15 and 97%. Measurement of TcPO2 provided a higher positive predictive value (79%) than TBP (67%). CONCLUSIONS: The results indicate that TcPO2 is a better predictor for ulcer healing than TBP in diabetic patients with chronic foot ulcers, and that the probability of ulcer healing is low when TcPO2 is &amp;lt; 25 mmHg.
Circulating Glucose and Insulin in Surgery for Insulomas
Authors: Norbert Schnelle
Journal: JAMA (1971)

Serial blood glucose and plasma immunoreactive insulin measurements during operations for insulomas were clinically useful in six patients. Mean blood glucose concentration rose by 40 mg/100 ml/hr during the initial 30 minutes after tumor removal, when no further functioning insuloma remained in situ. This information was available to the surgeon with a 15-minute delay. Insulin levels determined subsequently confirmed the assumptions based on glucose measurements. In addition to helping the surgeon to resect the least amount of pancreas necessary, these measurements enhanced the patient's safety from potentially dangerous hypoglycemia during anesthesia. Preoperative celiac arteriograms were done in five patients. They were helpful in localizing tumors in two patients and were retrospectively recognized to have correctly indicated the location of the tumor in a third patient.
The other handicap: brightness.
Authors: M E Lobascher, N P Cavanagh
Journal: BMJ (1977)

Because of changing attitudes to the measurement of mental abilities, only the slow child is assessed and receives special educational help. By contrast, the bright child may remain undetected because unassessed. For these children there are few special provisions, and they may present as behaviourally disturbed or educationally retarded. We describe four such children, and we feel that more facilities should be devoted to helping bright children, both at home and in school.
Enzymes in Clinical Medicine
Authors: Henry J. Tagnon
Journal: New England Journal of Medicine (1953)

THIS paper is restricted to a discussion of recent developments in the field of practical applications of enzymes in clinical medicine. No attempt can be made to discuss the general significance of enzymes in medicine because such an undertaking would be equivalent to reviewing the whole field of biochemistry as applied to medicine. It is generally recognized that, with a few exceptions, every chemical reaction occurring in the cells of the organism is catalyzed by enzymes.1 It follows that the study of normal metabolism at the fundamental level consists mostly of the study of chemical reactions that are made possible . . .
Leukemia in Children
Authors: S. Spence Meighan
Journal: JAMA (1964)

Information was collected about each child who died from leukemia in Oregon during the period 1950 to 1961. The annual incidence was 4.53 per 100,000. A peak of incidence occurred at three years. When the series was divided into two time periods (1950 to 1955, and 1956 to 1961), survival was found to be longer in the more recent group and suggests improved management of the disease in recent years. While the survival data in this study represent the fate of the leukemic child in contemporary America, they compare unfavorably with experience reported from medical centers. Two explanations are advanced for this: either treatment is more efficient in medical centers, or center experience is so selected that findings derived from it cannot safely be generalized.
ACUTE AGRANULOCYTOSIS FOLLOWING SULFADIAZINE
Authors: John J. Curry
Journal: JAMA (1942)

Toxic symptoms following the use of sulfadiazine in comparison with those following the other sulfonamides are mild and infrequent.  A decrease in the leukocyte count below 5,000 per cubic millimeter of blood with or without a decrease in the granulocytes occurs not uncommonly during the course of sulfanilamide and less often during sulfapyridine and sulfathiazole therapy. 1   Leukopenia following sulfadiazine administration has been observed. In a total of 776 cases 2 the incidence was 1.67 per cent. Keefer 1 reports an incidence of 2 per cent.  Acute agranulocytosis occurring after sulfadiazine therapy has not been reported. For this reason it was felt that the following case should be recorded.  REPORT OF CASE  A white woman aged 41, married, entered the medical wards of the Boston City Hospital on Sept. 24, 1941 because of [ill]aundice of five days' duration.  The present illness began about two weeks previously with an episode of
Photodermatitis from Soaps
Authors: Leonard J. Vinson
Journal: JAMA (1962)

<h3>To the Editor:—</h3> In recent months, reports have appeared in British journals on the photosensitizing action of 3,3′, 4′, 5 tetrachlorosalicylanilide (T<sub>4</sub>CS), a soap germicide now withdrawn from the European market. Dr. K. D. Crow (<i>Brit Med J</i><b>2</b>:1565 [Dec. 9] 1961), in discussing these findings, concludes that "it would seem reasonable to regard any halogenated salicylanilide as a potential skin hazard until proved otherwise." He cites one case of cross-sensitivity between T<sub>4</sub>CS and trichlorosalicylanilide. On the basis of our extensive experience with halogenated salicylanilides in soaps and other products (L. J. Vinson, et al.<i>J Pharmaceut Sci</i><b>50</b>:827-830, 1961; L. J. Vinson et al., Soap Chem Specialties [Oct.-Nov.], 1961), we agree that T<sub>4</sub>CS is a photosensitizer. We are not in agreement, however, with the conclusions, stated or implied, that all halogenated salicylanilides are phototoxic. A preliminary report is being assembled for
Outcome in patients with subarachnoid haemorrhage and negative angiography according to pattern of haemorrhage on computed tomography
Authors: G.J.E Rinkel, E.F.M Wijdicks, J van Gijn, D Hasan, M Vermeulen, L.M Hageman, G.E.M Kienstra, C.L Franke
Journal: The Lancet (1991)
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response
Authors: Margaret J Leckie, Anneke ten Brinke, Jamey Khan, Zuzana Diamant, Brian J O'Connor, Christine M Walls, Ashwini K Mathur, Hugh C Cowley, K Fan Chung, Ratko Djukanovic, Trevor T Hansel, Stephen T Holgate, Peter J Sterk, Peter J Barnes
Journal: The Lancet (2000)