tbuckley/cabot-search huggingface dataset:
Abstract 20413: Pattern of Atrial Fibrillation and the Risk of Ischemic Stroke - A Systematic Review and Meta-Analysis
Authors: Mandy N Lauw, Thomas Vanassche, Simona Masiero, John W Eikelboom, Stuart J Connolly
Journal: Circulation (2014)

Atrial fibrillation (AF) independently increases the risk of ischemic stroke. Reports differ on whether stroke risk is similar between different AF patterns; paroxysmal or permanent. While older studies reported no difference in stroke risk between AF patterns, recent oral anticoagulant trials suggested higher stroke rates in patients with permanent AF. We performed a systematic review to explore existing literature on stroke risk by AF pattern.  We systematically searched PubMed (January 1966 to April 2014) for clinical, randomized controlled trials or cohort studies that reported different AF patterns in patients before occurrence of stroke events and that reported stroke rates as a function of paroxysmal or permanent AF pattern. Two authors independently assessed eligible articles for inclusion and systematically extracted data of selected studies. A meta-analysis was performed with the included studies, and potential heterogeneity among studies was explored.  Of 411 identified citations, 18 papers with 134,847 AF patients were included and were analyzed according to use of oral anticoagulants (no OAC; OAC in all patients; mixed OAC use). The risk of stroke was lower for patients with paroxysmal AF than with permanent AF in all analyses (odds ratio (OR) 0.75; 95% CI 0.61-0.93 with no OAC; OR 0.77; 95% CI 0.68-0.88 with OAC in all patients; OR 0.70; 95% CI 0.58-0.84 with mixed OAC use; figure). Substantial heterogeneity was seen among studies with mixed OAC use (I2=46%), and moderate heterogeneity among studies with OAC in all patients (I2=24%).  Existing literature suggests a consistent lower stroke risk in patients with paroxysmal AF than with permanent AF. Whether AF pattern is an independent predictor of stroke or rather a reflection of patients’ stroke risk profile cannot be concluded from this review due to heterogeneous study designs and AF populations.
Bile Acids: Co-mutagenic Activity in the Salmonella-Mammalian-Microsome Mutagenicity Test: Brief Communication2
Authors: S. J. Silverman, A. W. Andrews
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Bile Acids: Co-mutagenic Activity in the Salmonella-Mammalian-Microsome Mutagenicity Test: Brief Communication Get access S. J. Silverman, S. J. Silverman Search for other works by this author on: Oxford Academic PubMed Google Scholar A. W. Andrews A. W. Andrews 6 6Address reprint requests to A. W. Andrews. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 59, Issue 5, November 1977, Pages 1557–1559, https://doi.org/10.1093/jnci/59.5.1557 Published: 01 November 1977 Article history Received: 06 December 1976 Accepted: 27 June 1977 Published: 01 November 1977
Effect of Enalapril on Endothelial Function in Young Insulin-Dependent Diabetic Patients: A Randomized, Double-Blind Study 11This study was supported by a grant from Merck Sharp and Dohme Ltd., Hertfordshire, England, United Kingdom. Ms. Donald is supported by a grant from the Coronary Artery Disease Research Foundation (CORDA), London, England, United Kingdom.
Authors: Michael J Mullen, Peter Clarkson, Ann E Donald, Hyeyoung Thomson, Sara A Thorne, Amanda J Powe, Takashi Furuno, Teresa Bull, John E Deanfield
Journal: Journal of the American College of Cardiology (1998)
Comparative effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) on priming peripheral blood progenitor cells for use with autologous bone marrow after high-dose chemotherapy
Authors: WP Peters, G Rosner, M Ross, J Vredenburgh, B Meisenberg, C Gilbert, J Kurtzberg
Journal: Blood (1993)
A Detailed Angiographic Analysis of Patients With Ambulatory Electrocardiographic Ischemia: Results From the Asymptomatic Cardiac Ischemia Pilot (ACIP) Study Angiographic Core Laboratory fn1fn1This study was funded by the National Heart, Lung, and Blood Institute, Cardiac Diseases Branch, Division of Heart and Vascular Diseases, National Institutes of Health, Bethesda, Maryland, by Research Contracts HV-90-07, HV-90-08, HV-91-05 to HV-91-14. Study medications and placebo were donated by Zeneca …
Authors: Barry L. Sharaf, David O. Williams, Nicholas J. Miele, Robert P. McMahon, PhD, Peter H. Stone, Preben Bjerregaard, Richard Davies, A.David Goldberg, Michael Parks, Carl J. Pepine, George Sopko, C.Richard Conti
Journal: Journal of the American College of Cardiology (1997)
Cross‐cultural adaptation of the Brazilian–Portuguese version of the chronic urticaria quality‐of‐life questionnaire – CU‐Q<sub>2</sub>oL
Authors: G. A. C. Dias, G. V. Pires, S. O. R. Valle, A. T. França, J. A. Papi, S. D. Dortas, S. A. P. Levy, I. Baiardini, G. W. Canonica
Journal: Allergy (2011)

To cite this article: Dias GAC, Pires GV, Valle SOR, França AT, Papi JA, Dortas SD Jr, Levy SAP, Baiardini I, Canonica GW. Cross‐cultural adaptation of the Brazilian‐Portuguese version of the chronic urticaria quality‐of‐life questionnaire ‐ CU‐Q 2 oL. Allergy 2011; 66 : 1487–1493 Summary Background: Chronic urticaria (CU) is a debilitating skin disorder that affects patients’ health related quality of life and the only questionnaire prepared specifically to CU is the Chronic Urticaria Quality of Life Questionnaire (CU‐Q 2 oL). Objective: The purpose of this study was to cross‐culturally adapt and validate the CU‐Q 2 oL Brazilian‐Portuguese version. Methods: Forward and back translation by three bilingual translators followed by pre‐test was used to adapt the questionnaire. The CU‐Q 2 oL was self‐administered along with the Dermatology Life Quality Index (DLQI) in 112 patients with CU. Disease activity was assessed using the Urticaria Activity Score. Factor analysis was used to identify scales of the Brazilian portuguese CU‐Q 2 oL. Internal consistency, convergent validity and known‐group validity was determined. Reproducibility was evaluated by interclass correlation coefficient (ICC). Multiple linear regression was used to determine the predicting factors of CU‐Q 2 oL results. Results: Factor analysis revealed a three‐dimensional structure: sleep/mental status/eating (I), pruritus/impact on life activities (II) and swelling/limits/look (III), which explained 52.49% of the total variance. All scales showed excellent internal consistency. External construct validity was supported by correlations between the CU‐Q 2 oL and DLQI. The tool was found to be able to differentiate between patients with high and low levels of urticaria activity. Test‐retest reliability was good to excellent (ICC = 0.69–0.86). Disease severity and urticaria type were the only factors predicting results. Conclusions: The CU‐Q 2 oL Brazilian portuguese version was easily filled out, well accepted by the patients, demonstrated an acceptable validity and reliability and might be used to evaluate treatment outcomes and in clinical research.
Blood Transfusion in Patients With Acute Coronary Syndrome—Reply
Authors: Sunil V. Rao, Robert A. Harrington, Robert M. Califf, Jonathan S. Stamler
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P4-07-01: Calorie restriction normalizes global microRNA expression by preventing the loss of dicer expression during mammary tumorigenesis
Authors: Kaylyn L Devlin, Tiffany Sanford, Elizabeth Mambo, Stephen D Hursting
Journal: Cancer Research (2015)

Abstract MicroRNA (miRNAs) are small, post-transcriptional regulators that play an integral role in maintenance of cellular functions and whose dyregulation has been shown to promote many types of cancer, including breast cancer. Global downregulation of miRNAs has emerged as a common theme in human breast tumors and has been shown to contribute to oncogenesis. One of the primary mechanisms through which miRNAs are globally dysregulated is downregulation of enzymes involved in miRNA biogenesis. We aim to establish how calorie restriction (CR), which potently inhibits breast cancer progression, regulates global miRNA expression and miRNA biogenesis enzyme functionality in mammary tumors. To address these questions, 100 female Sprague Dawley rats were administered either dimethylbenz(a)anthracene (DMBA) or vehicle control at 50 days of age, then randomized to receive either control (AIN-76A) diet ad-libitum (n=40) or a 30% CR diet regiment (n=60). Resultant mammary tumors were allowed to develop for 12 weeks. Calorie restriction significantly increased survival to study endpoint relative to control diet (75% vs 35%, respectively) (p=0.0047). Furthermore, of the animals that developed tumors, CR significantly decreased median tumor area by 56% compared to control diet (109.4 mm2 vs 250.9 mm2, respectively) (p=0.0286). Global miRNA expression was analyzed through miRNA-specific sequencing. Calorie restriction had a broad effect on miRNA expression, illustrated by the fact that of all the miRNAs with a greater than two-fold expression difference between CR and control, 80% are overexpressed in CR tumors compared to control tumors. These results can be explained by the additional finding that CR was able to prevent the loss of Dicer expression, a key miRNA biogenesis enzyme, observed in control-fed mammary tumor tissue compared to normal tissue. This important finding suggests that global miRNA normalization through the retention of Dicer expression during cancer progression could be a contributing mechanism to CR’s anticancer effects. We plan to further these investigations by exogenously manipulating Dicer expression in Rama25 cells, which were originally derived from a DMBA-induced mammary tumor from a Sprague Dawley rat, and analyzing the resultant tumorigenic potential in vitro and in vivo. The results obtained will provide insights into the mechanisms of breast cancer progression and how CR inhibits progression through microRNA modulation. Citation Format: Kaylyn L Devlin, Tiffany Sanford, Elizabeth Mambo, Stephen D Hursting. Calorie restriction normalizes global microRNA expression by preventing the loss of dicer expression during mammary tumorigenesis [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-07-01.
Don't Call Me "Larry"
Authors: A R Hochstadt, A R Hockstadt
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Daha Önceden Tedavi Almamış Yaygın-Evre Küçük Hücreli Akciğer Kanseri Bulunan Hastalarda İrinotekan/Platin ile Etoposit/Platin'i Karşılaştıran Randomize Kontrollü Çalışmaların Bir Meta-analizi
Authors: Jingwei Jiang, Xiaohua Liang, Xinli Zhou, Lizhen Huang, Ruofan Huang, Zhaohui Chu, Qiong Zhan
Journal: Journal of Thoracic Oncology (2010)
Current allergic asthma and rhinitis: diagnostic efficiency of three commonly used atopic markers (IgE, skin prick tests, and Phadiatop®)
Authors: J. M. Tschopp, D. Sistek, C. Schindler, P. Leuenberger, A. P. Perruchoud, B. Wüthrich, M. Brutsche, J. P. Zellweger, W. Karrer, O. Brändli
Journal: Allergy (1998)

Total serum IgE, Phadiatop®, and the skin prick test (SPT) are commonly used to diagnose atopic diseases. However, no large study has ever been done to test their diagnostic efficiency. We studied the diagnostic value of these three atopic markers in 8329 well‐randomized adults from the Swiss Population Registry. The prevalence of current allergic asthma (CAA) was 1.8% and of current allergic rhinitis (CAR) 16.3%. The prevalences of positive Phadiatop, positive SPT (at least, one out of eight SPT to common aeroallergens with a wheal of &gt;3 mm), and positive total IgE (IgE &gt;100 kU/1) were 29, 23, and 23%, respectively. To diagnose CAA and CAR. the sensitivity of Phadiatop was significantly higher than that of SPT (72.5% vs 65.4%, 77.1% vs 68.4% respectively; P&lt;0.01 and &lt;0.001) and IgE (72.5% VA‐ 56.9%, 77.1% vs 43.9%, respectively; both p&lt;0.001). The sensitivity of SPT was significantly higher (68.4% vs 43.9% P&lt;0.001) than that of IgE to diagnose CAR. When CAA and CAR were excluded, the SPT specificity was significantly higher than that of Phadiatop (77.8% vs 71.9% and 85.9% vs 80.5%, respectively; both P&lt;0.001): when CAR was excluded, SPT was significantly higher than IgE (85.9 vs 81.4%; P&lt;0.001). SPT had significantly the best positive predictive value for CAA (5.2% for SPT vs 4.6% for both IgE and Phadiatop; both P&lt;0.001) and CAR (48.7% for SPT vs 43.5% for Phadiatop and 31.6% for IgE; both P&lt;0.001). The three markers of atopy had roughly the same negative predictive value (NPV) for CAA, but IgE had a significantly lower NPV for CAR than SPT and Phadiatop (88.1% vs 93.3% and 94.7%, respectively; both P&lt;0.001). The diagnostic efficiency of SPT was significantly higher than that of Phadiatop (83.1% vs 79.9% and 77.6 vs 71.9%, respectively; both F&lt;0.001) to diagnose CAR and CAA. IgE and SPT had equal efficiency (77.6%), which was significantly higher than that of Phadiatop, to diagnose CAA (71.9%; both P&lt;0.001). In conclusion, SPT have the best positive predictive value and the best efficiency to diagnose respiratory atopic diseases. Furthermore, SPT give information on sensitivity to individual allergens and should therefore be used primarily by clinicians to assess respiratory allergic diseases. Moreover, they are cheaper and provide immediate, educational information for both patient and physician.
Effect of progesterone on the development of mammary cancer in C3H mice.
Authors: Harold Burrows, Cornelia Hoch-Ligeti
Journal: Cancer Research (1946)

This report investigates the effect of progesterone on the incidence of spontaneous mammary tumors in a pure strain of C3H female mice.  30 mice received subcutaneous injections of 1 mgm crystallized progesterone dissolved in 0.2 cc. arachis oil; 20 control mice received the oil only.  The mice were inspected weekly for appearance of tumors.  No difference could be established in the incidence of tumors nor in the age of the appearance of the tumors in the treated and untreated mice.
Navigating the Body’s Water Channels, Scientists Gain Insights Into Disease
Authors: Tracy Hampton
Journal: JAMA (2004)

AS EVERY MEDICAL STUDENT IS taught, water constitutes about two thirds of the body, and the physiological activities that rely on water are numerous and diverse. With water playing such a crucial role in human life, getting it to where it is needed is equally important. While simple diffusion of water molecules across cell membranes occurs in some cases, regulated trafficking in and out of cells is often required. That is where aquaporins come in. Although scientists suspected that such water channels existed, it was not until the early 1990s that aquaporins were discovered in the laboratory of Peter Agre, MD, of Johns Hopkins University School of Medicine, in Baltimore, Md. Researchers are now learning that a wide range of clinical conditions— including diabetes, brain edema, cirrhosis, congestive heart failure, and glaucoma—are linked to compromised aquaporin function, and in some cases, they are devising potential therapies based on their findings.
Drug resistant bacteria cause fresh concerns
Authors: Scott Gottlieb
Journal: BMJ (2000)

Infections caused by so-called “superbugs,” resistant to most available antibiotics, are causing renewed concerns worldwide. Four recent outbreaks of new and more virulent strains of disease caused by contact with animals or contaminated food have been reported in the New England Journal of Medicine .

“The underlying cause of why these things happen is the changing food supply, growing world population, international travel, and overuse of antibiotics,” said Dr Michael Osterholm, the chief executive officer of Ican, a medical information company and author of an accompanying editorial on the topic (2000;342:1280-1).

In one of the four studies …
Alterations of the Architecture of Subendocardial Arterioles in Patients With Hypertrophic Cardiomyopathy and Impaired Coronary Vasodilator Reserve: A Possible Cause for Myocardial Ischemia 11This study was supported by Grant SFB 242: Koronare Herzkrankheit: Prävention und Therapie akuter Komplikationen from the Deutsche Forschungsgemeinschaft, Bonn, Germany.
Authors: Bodo Schwartzkopff, Markus Mundhenke, Bodo E. Strauer
Journal: Journal of the American College of Cardiology (1998)
Abstract 15598: SDPR/Cavin-2 Modulates Akt Sgnaling Involved in Regulation of Hypertrophy and Apoptosis in Cardiomyocytes
Authors: Naoki Maruyama, Takehiro Ogata, Naohiko Nakanishi, Tetsuro Hamaoka, Kotaro Miyagawa, Takeru Kasahara, Tomomi Ueyama
Journal: Circulation (2014)

Introduction: SDPR/Cavin-2 is a member of the cavins which belongs to caveolar related proteins. SDPR/Cavin-2 regulates caveolar formation in a variety of cell types.The structural role of SDPR/Cavin-2 in caveolae has been well studied. However, its functional role remains unknown. Here, we present a novel functional role of SDPR/Cavin-2 in cardiomyocytes. Methods and Results: To examine the functional role of SDPR/Cavin-2 in cardiomyocytes, we generated SDPR/Cavin-2 knock-out (SDPR-/-) mice and knocked down SDPR/Cavin-2 expression in neonatal rat cardiomyocytes using adenovirus expressing SDPR/Cavin-2 shRNA. SDPR-/- mice developed a progressive cardiac hypertrophy. At fourteen weeks of age, SDPR-/- mice had a significantly higher heart weight/body weight ratio than wild-type mice. SDPR-/- mice displayed significant concentric hypertrophy as revealed by echocardiography. In vitro study, increased cardiomyocyte surface area, which was associated with induction of hypertrophy-related fetal gene expression, ...
Extra 2600 physicians needed Britain
Authors: Roger Dobson
Journal: BMJ (2001)

Consultant numbers in many specialties need to double if existing quality of care for patients is to be maintained, according to the report of the annual census of the Royal College of Physicians, which covered England, Wales, and Northern Ireland.

Consultant physicians are working longer hours than they are contracted for, and in many cases are exceeding 48 hours a week, the legal limit set by the …
Functional lung MRI in COPD: Comparative assessment of T1 mapping, oxygen-enhanced T1 mapping and perfusion MRI at 1.5 Tesla
Authors: Bertram Jobst, Simon Triphan, Oliver Sedlaczek, Angela Anjorin, Hans-Ulrich Kauczor, Jürgen Biederer, Julia Ley-Zaporozhan, Sebastian Ley, Mark Wielpütz
Journal: European Respiratory Journal (2014)

Objectives:  Lung function testing provides limited information on regional lung characteristics. Therefore, alternative endpoints for interventional trials are pivotal. T1 relaxation times in lung MRI are known to depend on tissue composition including the blood volume fraction. The aim of this study was to validate T1 mapping and oxygen-enhanced (OE) T1 mapping against first-pass perfusion MRI in COPD patients.  Methods:  20 COPD patients (GOLD I-IV) underwent MRI, comprising of a coronal 2-dimensional inversion recovery snapshot flash sequence (8 slices/lung) at room-air and after supplementing pure oxygen, as well as perfusion imaging with high temporal resolution (1.5 s per lung) at room-air. The spatial extent of abnormal T1 at room-air (T1RA), restricted oxygen-induced T1 shortening (ΔT1) and perfusion deficits were rated by 2 chest radiologists in consensus using a semi-quantitative 3-point scale in a zone-based approach.  Results:  T1RA correlated positively with the extent of perfusion deficits (r=0.81; p  Conclusion:  T1 mapping and OE T1 mapping corresponded well with perfusion MRI and GOLD stage, and provide complementary information about blood volume distribution in COPD. In particular, OE T1 mapping contributes to the differentiation of hypoxic vasoconstriction and genuine perfusion impairment.
Elevated soluble MUC1 levels and decreased anti-MUC1 antibody levels in patients with multiple myeloma
Authors: Steven P. Treon, Peter Maimonis, Deborah Bua, Gloria Young, Noopur Raje, Joseph Mollick, Dharminder Chauhan, Yu-Tzu Tai, Teru Hideshima, Yoshihito Shima, Jo Hilgers, Silvia von Mensdorff-Pouilly, Andrew R. Belch, Linda M. Pilarski, Kenneth C. Anderson
Journal: Blood (2000)