tbuckley/cabot-search huggingface dataset:
Late relapse of testicular cancer.
Authors: H R Terebelo, H G Taylor, A Brown, N Martin, F H Stutz, J Blom, L Geier
Journal: Journal of Clinical Oncology (1983)

The complete response (CR) rate of disseminated germ-cell tumors with current aggressive chemotherapy and surgical resection of localized residual disease is between 70%-80%. Most patients who relapse do so within the first year of therapy. We have observed seven patients with germ-cell tumors treated with a variety of modalities who relapsed after more than two years in CR (45-87 months). Five patients are alive after salvage therapy with follow-up too short to assess the durability of second remission. There were no features distinguishing late relapse patients from all patients treated with chemotherapy for germ-cell tumors. Follow-up in patients treated for germ-cell tumors with chemotherapy should be extended to five years before curability can be established.
Does chronic post-thrombotic iliofemoral vein obstruction limit exercise capacity?
Authors: Michael Segel, Ronen Reuveny, Jacob Luboshitz, Dekel Shlomi, Issahar Ben-Dov
Journal: European Respiratory Journal (2014)

Background: After deep vein thrombosis (DVT), local symptoms of chronic venous insufficiency are well described, but little is known about the effect of post-thrombotic venous obstruction on exercise capacity.  Hypothesis: Chronic residual venous occlusion after DVT may cause reduced exercise capacity.  Methods: Subjects were 6 post-DVT patients with residual iliofemoral vein occlusion and effort intolerance, with no cause identified by standard workup; controls were 8 healthy volunteers. Exercise tolerance was assessed by bimodality incremental symptom-limited cardiopulmonary testing, using leg or arm ergometers. Leg vein obstruction was modeled by application to the thighs of cuff tourniquets inflated to 30mmHg. Results are median (range).  Results: Leg exercise tolerance as measured by oxygen consumption at peak exercise (peak V9O2) was reduced (46% predicted (36-67%) in patients vs 89% (77-130%) in controls, p=0.007). Arm exercise tolerance was also reduced, but less severely than in the legs - the arm:leg ratio of peak V9O2 was 1.14 (0.77-1.43) in patients vs 0.71 (0.6-1.0) in controls, p  Conclusions: The comparison of exercise capacity in arm vs leg exercise of post-DVT patients with residual iliofemoral vein occlusion; and the effect of experimental venous obstruction (thigh tourniquets) in healthy controls; suggest that reduced exercise capacity in patients was at least partially caused by reduced venous return, as simulated in controls. Chronic venous obstruction should be recognized as an exercise limiting factor.
Natural history of node-positive breast cancer: the curability of small cancers with a limited number of positive nodes.
Authors: C A Quiet, D J Ferguson, R R Weichselbaum, S Hellman
Journal: Journal of Clinical Oncology (1996)

PURPOSE The long-term outcome of node-positive breast cancer was analyzed to determine the risk of metastatic disease as a function of tumor size and number of positive nodes. METHODS From 1927 to 1987, 501 women with node-positive breast cancer were treated at the University of Chicago Medical Center. Patients were treated with radical, extended radical, or modified radical mastectomy. Forty-eight patients received multiagent chemotherapy, and 118 were treated with hormonal therapy. The mean survival duration is 120 months, with a maximal follow-up time of 485 months (40 years). RESULTS The number of nodes that contained metastatic disease and the pathologic size of the primary tumor were significant determinants of disease-free-survival (DFS) by multivariate analysis (P &lt; .001). In patients with fewer than four positive nodes, tumor size was of prognostic importance, with small tumors more likely to be cured by local-regional therapy. The 20-year DFS rate for patients with one positive node was 69%; however, if the primary tumor was &lt; or = 2 cm, the 20-year DFS rate was 81%, compared with 59% if the tumor was larger than 2 cm. Patients with two or three positive nodes had a 73% 20-year DFS rate if the tumor size was &lt; or = 2 cm, compared with 53% 20-year DFS in patients with tumors larger than 2 cm. CONCLUSION In patients with T1 lesions with less than four nodes positive, the long-term DFS rate is comparable to that for node-negative breast cancer of the same size. Four or more nodes positive is an indicator of likely systemic disease.
Basic vs Advanced Life Support for Out-of-Hospital Cardiac Arrest—Reply
Authors: Prachi Sanghavi, Anupam B. Jena, Alan M. Zaslavsky
Journal: JAMA Internal Medicine (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Functional evaluation of members of the LIV-1 family of proteins and their role in breast cancer
Authors: Normawati Mohamad Zahari, Kathryn Taylor, Robert Nicholson
Journal: Clinical Cancer Research (2008)

All nine members of the LZT subfamily have similarities to members of the ZIP superfamily, especially in the region associated with their ability to transport zinc intracellular. Computer analysis of the nine sequences suggests that they are all members of this subfamily, however, in phylogenetic tree some members group separately, suggesting differences in function. The LZT-Hs7, LZT-Hs8 and LZT-Hs9 were cloned into a vector suitable for expression of recombinant proteins in mammalian cells. For the first time, this demonstration showed, a plasma membrane location for LZT-Hs7 and LZT-Hs8 which similar finding to LIV-1, and an intracellular location for LZT-Hs9, similar to that observed previously for LZT-Hsl. In addition, zinc transport capability was investigated. Affymetrix U133A analysis of LZT-Hsl, LIV-1, LZT-Hs4, LZT-Hs5 and pS2 confirmed that LZT-Hsl, LIV-1 and LZT-Hs4 were regulated by estradiol. This study was extended to investigate the expression of all nine family members in breast cancer cells treated with oestradiol, anti- oestrogens and additionally in tamoxifen and faslodex resistant cells, using semi-quantitative PCR. Differential expression of these family members was seen with some members constitutively expressed whilst others either elevated or reduced in the different conditions. This analysis demonstrated that LZT-Hsl was considerably elevated in tamoxifen resistance. In an effort to investigate a possible role for LZT-Hsl in tamoxifen resistant cells, it was reduced by siRNA. Interestingly, in the presence of siRNA for LZT-Hsl, it was not possible to demonstrate the activation of EGFR or Src as previously observered in the tamoxifen resistant phenotype using Western blotting analysis. This is an exciting result, which suggests a role for LZT-Hsl in driving the growth of tamoxifen resistant breast cancer cells.
Expression of mRNA chemokine and their receptors in nasopharingeal brush-biopsies represents age of bronchial asthma patients
Authors: Kirill Sysoev
Journal: European Respiratory Journal (2013)

Introduction: System of chemokines in upper airways is a tempting object of investigation BA pathogenesis. Methods: 70 patients with asthma were examined. Range of age of the patients was 16-74 years. Sex distribution was 31 male and 39 female. To study the age dynamics of the asthma patients were divided into 4 groups: first group - 16-25 years (14), the second group - 26-39 years (14), the third group - 40-53 years (21) and the fourth group - 54-74 years (21). The control were 17 healthy volunteers who were excluded diseases of the upper and lower respiratory tract. Results: mRNA of eotaxin, eotaxin-2, MIP-1α, MIP-1β, RANTES, CCR1, CCR3, CCR5, CXCR1, and CXCR2 were studied. Increase in eotaxin mRNA expression (p = 0.045), eotaxin-2 (0.036), MIP-1α (0.0003), MIP-1β (0.002) and CXCR1 (0.004) was indicated. The reduction of CCR1 gene expression in patients with asthma was assessed. Eotaxin-2 had wave-like dynamics depending on patents age. MIP-1α was lowest in the second and third groups, and in the first and fourth - were significantly higher. mRNA of CCR1 and CXCR1 was significantly decreased in the second group compared to the first, meanwhile in the third and fourth ones levels of mRNA of both receptors increases depending on the age of the patients. Conclusion: The state of chemokines and relative receptors gene expression in upper airways represents age features of BA pathogenesis. The evaluation of nasopharyngeal brush-biopsies chemokine mRNA expression is perespective dignostic approach to investigate asthma pathogenesis and clinical course.
The frequency of fragrance allergy in a patch-test population over a 17-year period
Authors: D.A. Buckley, S.H. Wakelin, P.T. Seed, D. Holloway, R.J.G. Rycroft, I.R. White, J.P. McFadden
Journal: British Journal of Dermatology (2000)

Fragrances are widely encountered in our daily environment and are known to be a common cause of allergic contact dermatitis. We have reviewed our patch test data from 1980 to 1996 to establish whether the pattern of fragrance allergy has changed with time. During this period, 25,545 patients (10,450 male, 15,005 female) were patch tested with the European standard series. The mean annual frequency of positive reactions to the fragrance mix was 8·5% in females (range 6·1–10·9) and 6·7% in males (range 5·1–12·9). Females were 1·3 times more likely to be allergic to fragrance (P < 0·001, 95% confidence interval, CI 1·17–1·41). Males with fragrance allergy were older than females by 5·6 years (mean age 48·2 vs. 42·6 years; P < 0·001, 95% CI 3·9–7·3). The incidence of a concomitant positive patch test to balsam of Peru in fragrance‐sensitive patients showed wide variation, suggesting that it is not a reliable marker of fragrance allergy. There was a positive correlation between the isomers isoeugenol and eugenol. Oak moss remained the most common overall allergen throughout the study, positive in 38·3% of females and 35·6% of males who were tested to the constituents of the fragrance mix. During the period of the study the incidence of positive tests to oak moss increased by 5% yearly (P = 0·001, 95% CI 2·2–8·7). The frequency of allergic reactions to eugenol and geraniol remained relatively constant. Isoeugenol and alpha‐amyl cinnamic aldehyde sensitivity increased and hydroxycitronellal showed a slow decline. There was a striking reduction in the frequency of sensitivity to cinnamic aldehyde (by 18% yearly; P < 0·001, 95% CI 14·3–21·0) and cinnamic alcohol (by 9% yearly; P < 0·001, 95% CI 5·2–12·9); these are now uncommon fragrance allergens. These data show temporal trends which may reflect the frequency of population exposure to individual fragrances.
Physiological correlates to physical activity in obese patients with obstructive sleep apnea (OSA)
Authors: J.C. Rambert, R. Rusca Mestre, M. Croteau, S. Gorain, B. Wuyam, R. Tamisier, P. Levy, F. Maltais, J.L. Pépin, I. Vivodtzev
Journal: European Respiratory Journal (2013)

Background: Obesity and OSA are closely interconnected conditions both leading to reduced exercise tolerance and low physical activity. We investigated physiological correlates of spontaneous physical activity in obese OSA.  Methods: 38 obese CPAP-treated OSA (age = 53 ± 3 years; BMI= 38 ± 3 kg/m²) consecutively included in a larger randomized multicenter study performed 5-day actigraphy as well as measurements of pulmonary function, body composition, quadriceps and respiratory muscle strength, and exercise tolerance (six-minute walking distance -6MWD- and maximal aerobic capacity on cycloergometer). Quality-of-life was assessed by the SF-36 questionnaire and sleepiness by the Epworth questionnaire.  Results: The mean number of step per day was 7182 ± 2594 and the mean intensity of physical activity was 1.1 ± 0.1 METS, with a mean total energy expenditure of 3123 ± 499 kcal/day. The number of steps per day was correlated with FEV1, (r = 0.38, p = 0.02), Epworth score (r = -0.31, p = 0.06), VO2peak (r = 0.30, p = 0.06) and 6MWD (r = 0.38, p = 0.06). The number of METS tended to correlate with maximal workload (r = 0.32; p = 0.06) and VO2peak (r = 0.30, p = 0.08). IMC, fat-free-mass and perception of dyspnea and leg discomfort during exercise did not influence physical activity.  Conclusion: Pulmonary function and sleepiness may significantly influence the number of step per day in obese OSA although the intensity of physical activity appears to be further impacted by exercise capacity.
Association between COPD and other co-morbid conditions: Results from a 1-day, point-prevalence study in 2,04,912 patients from 860 cities and towns in India
Authors: Sapna Madas, Komalkirti Apte, Monica Barne, Sonali Harangule, Jaideep Gogtay, Sushmeeta Chhowala, Nadar Mahajan, Salvi Sundeep
Journal: European Respiratory Journal (2012)

COPD is known to be associated with various systemic manifestations. We aimed to study the association between COPD and cardiovascular disease, diabetes and anemia in a cohort of patients from 22 states and 5 union territories in India. Methodology: 13,225 general practitioners (GPs) and general physicians (Gen Ps) from 860 cities and towns were randomly selected and invited to participate in this 1-day point-prevalence, cross-sectional study. On 1st February 2011 all participating doctors captured details of age, gender, presenting symptoms and diagnosis of all patients who visited them. Clean data was transferred into the EPI INFO software and associations between COPD and other co-morbid conditions were analyzed using chi-square test. Results: 7,400 doctors consented and provided clean data of 2,04,912 patients (M: 54.1%; F: 45.9%) who visited their clinic/hospital. Out of these 6118 (3.0%) patients had COPD. Presence of doctor-diagnosed COPD was strongly associated with co-presence of ischemic heart disease (IHD) [OR: 2.66 (2.3, 3.0);p
Clinical index to evaluate the risk of primary ciliary dyskinesia in children
Authors: Jana Djakow, Eva Rozehnalova, Magdalena Havlisova, Tamara Svobodova, Petr Pohunek
Journal: European Respiratory Journal (2012)

Introduction: Primary ciliary dyskinesia (PCD) is a rare genetic disorder causing a variety of symptoms. The diagnostics of PCD is challenging as the clinical presentation can differ in particular patients. Also the methods (as high-speed videomicroscopy or electron microscopy) to diagnose PCD are usually available only in specialized centres.

Aim & objective: To find out if a simple clinical index can be used to differentiate the patients with high risk of PCD.

Methods: All patients with PCD diagnosed in our clinic (n=31) and all patients sent to the diagnostic centre as suspected of PCD in 2009-2011 (n=352) were included into the study. We randomly divided the study group into 2 subgroups. The analysis subgroup was used for model preparation and hold-out group was used for subsequent cross-validization of the model. We measured quality of the test (model) by computing area under ROC curve (AUC) and discriminant validity by comparing total scores for group with or without PCD diagnosis.

Results: The clinical index included 7 yes/no questions concerning the history and clinical symptoms. One point was assigned to each yes answer. AUC for analysis subsample was 0.94, AUC for hold-out subsample 0.89. Discriminant validity was measured in whole study group by non-parametric Mann-Whitney U-test: (U=555.5, Z=-7.08, p<0.0001).

Conclusions: A simple clinical 7-item questionnaire can be used to evaluate the risk of PCD and to discriminate the patients that should be referred to diagnostic centre.
Methacholine reactivity and asthma
Authors: B. Lundbäck, N. Stjernberg, L. Rosenhall, M. Lindström, E. Jönsson, S. Andersson
Journal: Allergy (1993)

Methacholine tests were used in an epidemiologic study of the prevalence of asthma and chronic bronchitis in northern Sweden. Of 6610 subjects in three age groups from eight representative geographic areas in the northernmost province of Sweden, 5698 (86%) completed a postal questionnaire on respiratory symptoms, and 1506 underwent a structured interview and a lung function test. A total of 292 (5%) were diagnosed as having asthma. A subsample of 284 subjects (of 320 invited) classified at the interview as having asthma ( n = 98) or as having respiratory symptoms that might be due to asthma but not fulfilling the interview criteria for the diagnosis of asthma ( n = 186) underwent a methacholine test. Subjects who, before the interview study, already had a well‐defined asthma diagnosis were not invited to the methacholine testing. Of those 98 subjects classified as having asthma, 61 % reacted to methacholine doses ≤ 4 mg/ml and 79% to doses ≤ 8 mg/ml, while the corresponding figures in the symptomatic but nonasthma group were 20% and 34%, respectively. The results show that a carefully performed structured interview accurately diagnoses asthma in epidemiologic studies. The methacholine tests provide important diagnostic information primarily in subjects in whom the medical history is equivocal.
Low grade systemic inflammation and lung function outcomes in European adults from the global asthma and allergy network of excellence (GA2LEN) follow-up survey
Authors: Vanessa Garcia-Larsen, Meinir Jones, James F. Potts, Roger B. Newson, Daniel Obaseki, Peter G.J. Burney
Journal: European Respiratory Journal (2014)

Background   Low grade systemic inflammation may intefere with maintenance of lung function. We have investigated the association between serum inflammatory markers and lung function in European adults.   Methods   The study sample was drawn from the GA 2 LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. A stratified random sample was obtained for follow-up. 1,670 participants performed pre- and post- bronchodilator spirometry. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV1) and FVC (FEV 1 /FVC), FVC below lower limit of normal (FVClLLN) and FEV 1 /FVClLLN were calculated. Serum levels of C-reactive protein (CRP), Interleukin 6 (IL-6), Interleukin 8 (IL-8), Tumor Necrosis Factor alpha (TNFα), Transforming Growth Factor b (TGF-β) and Myeloperoxidase (MPO) were measured. Lung function and exposures were weighted to obtain estimated population parameters. Associations were investigated with linear regressions.   Results   CRP and IL-6 were negatively associated with FVC (adjusted effect size per doubling (95% Confidence Interval [CI] -0.05 (-0.08 to -0.03) and -0.09 (-0.14 to -0.04), respectively) and CRP was positively related to a higher prevalence of FVClLLN (OR per doubling 1.29 (95% CI 1.04 to 1.61). CRP, IL-6 and MPO were positively associated with FEV 1 /FVClLLN (Odds Ratios [OR] per doubling [95% CI] 1.37 [1.11 to 1.70]; 1.73 [1.14 to 2.64]; and 1.22 [1.00 to 1.48], respectively.   Conclusion   A better FVC was associated with lower levels of CRP and IL-6. CRP, IL-6 and MPO were associated with a higher prevalence of lung obstruction.
Keynote-029: Phase 1/2 Study of Mk-3475 in Combination with Pegylated Interferon Alfa-2B (Peg-Ifn) or Ipilimumab (Ipi) in Patients (Pts) with Advanced Melanoma (Mel) or Renal Cell Carcinoma (Rcc)
Authors: T.K. Choueiri, A. Ribas, F.S. Hodi, J. Thompson, W. Hwu, A. Tosolini, R. Iannone, Z. Yang, C. Gause, R. Perini, M.B. Atkins
Journal: Annals of Oncology (2014)
Cardiac Arrest in Pregnancy
Authors: Farida M. Jeejeebhoy, Carolyn M. Zelop, Steve Lipman, Brendan Carvalho, Jose Joglar, Jill M. Mhyre, Vern L. Katz, Stephen E. Lapinsky, Sharon Einav, Carole A. Warnes, Richard L. Page, Russell E. Griffin, Amish Jain, Katie N. Dainty, Julie Arafeh, Rory Windrim, Gideon Koren, Clifton W. Callaway
Journal: Circulation (2015)

This is the first scientific statement from the American Heart Association on maternal resuscitation. This document will provide readers with up-to-date and comprehensive information, guidelines, and recommendations for all aspects of maternal resuscitation. Maternal resuscitation is an acute event that involves many subspecialties and allied health providers; this document will be relevant to all healthcare providers who are involved in resuscitation and specifically maternal resuscitation.
Enhancement of Friend Virus Leukemia by Leucogenenel2
Authors: Stephen C. Elliott, Andrew N. Jacoby, Mark A. Barnhill, William E. Howard
Journal: JNCI Journal of the National Cancer Institute (1973)

We studied the effects of leucogenenol (C18H25NO8) on Friend virus (FV) leukemia in female BALB/c mice. Leucogenenol given before, before and after, or after FV infection augmented the leukemic process. That leucogenenol potentiated the leukemia in test animals was shown by higher peripheral nucleated cell counts, higher spleen and liver weights, more abnormal cells in peripheral differentials, and, in one set of animals, rapid mortality. The elevated humoral antibody titer in FV-infected animals given leucogenenol was ascribed an important role in potentiating the disease. It was also suggested that leucogenenol increased a stem-cell pool and thus enhanced both B-cell immunogenesis and leukemogenesis.
Use of deferred consent for enrolment in trials is fraught with problems
Authors: Liaquat R Johnson, Rangaswamy Siddaiah
Journal: BMJ (2015)

“Deferred consent” seems to be an ill disguised instrument to pre-emptively circumvent many trial problems.1 It almost eliminates the possibility of refusal and helps reduce subject bias because participants are unaware of recruitment during the intervention phase. It also reduces the risk of contamination, again because of the participant’s ignorance.

The recurrent theme is that of ignorance about recruitment, which seems …