THE ORAL ADMINISTRATION OF VITAMIN B_12 IN TROPICAL SPRUE
Authors: F DIEZ RIVAS, R M SUAREZ, F HERNANDEZ MORALES, E PEREZ SANTIAGO
Journal: Annals of Internal Medicine (1952)

Article1 February 1952THE ORAL ADMINISTRATION OF VITAMIN B12 IN TROPICAL SPRUEFEDERICO DIÉZ RIVAS, M.D., RAMÓN M. SUÁREZ, M.D., F.A.C.P., FEDERICO HERNÁNDEZ MORALES, M.D., F.A.C.P., ENRIQUE PÉREZ SANTIAGO, M.D.FEDERICO DIÉZ RIVAS, M.D.Search for more papers by this author, RAMÓN M. SUÁREZ, M.D., F.A.C.P.Search for more papers by this author, FEDERICO HERNÁNDEZ MORALES, M.D., F.A.C.P.Search for more papers by this author, ENRIQUE PÉREZ SANTIAGO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-2-583 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThree years ago, Shorb1 discovered a new factor in refined liver extracts that was highly potent in promoting growth of the microörganism Lactobacillus lactis Dorner. Using the microbiologic method of Shorb, Riches2 et al. isolated a pure crystalline compound from liver and designated it vitamin B12. West3 proved that this substance possessed the property of inducing a hematopoietic response in patients with pernicious anemia in relapse. At about the same time, Smith4 in England announced the isolation of a factor apparently identical to vitamin B12.CHEMISTRY OF VITAMIN B12Crystalline vitamin B12occurs as dark red needles. On a weight-for-weight...Bibliography1. Shorb MS: Activity of vitamin B12 for the growth of Lactobacillus lactis , Science 107: 397, 1948. CrossrefMedlineGoogle Scholar2. RichesBrinkKonuissyWoodFolkers ELNGFRTRK: Comparative data on vitamin B12 from liver and from a new source Streptomyces griseus , Science 108: 634, 1948. CrossrefGoogle Scholar3. West R: Activity of vitamin B12 in Addisonian pernicious anemia, Science 107: 398, 1948. CrossrefMedlineGoogle Scholar4. Smith EL: Purification of anti-pernicious anemia factor from liver, Nature 161: 638, 1948. CrossrefMedlineGoogle Scholar5. West R: Vitamin B12 a cobalt complex, Science 108: 134, 1948. CrossrefGoogle Scholar6. Smith EL: Presence of cobalt in the anti-pernicious anemia factor, Nature, London 162: 144, 1948. CrossrefMedlineGoogle Scholar7. BethellMeyersNeleigh FHMCRB: Vitamin B12 in pernicious anemia and puerperal macrocytic anemia, J. Lab. and Clin. Med. 33: 584-591, 1948. Google Scholar8. ErfWeimer LABM: Blood. To be published. Google Scholar9. HallCampbell BEDC: Vitamin B12 therapy in pernicious anemia, Proc. Staff Meet., Mayo Clin. 23: 584-591, 1948. MedlineGoogle Scholar10. SpiesSuárezGarcia-LopezMilanesStoneLopez-TocaAbramburnKartus TDRMGFRERTS: Tentative appraisal of vitamin B12 as a therapeutic agent, J. A. M. A. 139: 521 (Feb.) 1948. CrossrefGoogle Scholar11. BerkCastleWelchHeinleAuberEpstein LWBARWRM: Observations on the etiologic relationship of achylia gastrica to pernicious anemia. X. Activity of vitamin B12 as food (extrinsic) factor, New England J. Med. 239: 911 (Dec.) 1948. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication August 14, 1950.From the Department of Clinical Medicine, University of Puerto Rico, School of Tropical Medicine.We are indebted to Dr. Tom D. Spies, Director of the Nutrition Clinic, Hillman Hospital, Birmingham, Alabama, for supplying some of the vitamin B12 used in this study. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTropical Sprue and Vitamin B 12Antibiotic Therapy in Tropical SprueTHE ORAL USE OF COMBINED VITAMIN B12 AND FOLIC ACID IN TROPICAL SPRUE*RIVAS FEDERICO DIÉZ, M.D., MORALES FEDERICO HERNÁNDEZ, M.D., F.A.C.P., LEO M. MEYER, M.D. 1 February 1952Volume 36, Issue 2_Part_2Page: 583-591KeywordsLactobacillusLiverNutritionOral administrationPernicious anemia Issue Published: 1 February 1952 PDF downloadLoading ...