tbuckley/cabot-search huggingface dataset:
Economic evaluation of maintenance treatment with tacrolimus 0·1% ointment in adults with moderate to severe atopic dermatitis
Authors: A. Wollenberg, M.K. Sidhu, I. Odeyemi, B. Dorsch, R. Koehne-Volland, M. Schaff, B. Ehlken, K. Berger
Journal: British Journal of Dermatology (2008)

Rational health care decision-making based on outcomes and economic evidence is essential to provide the best possible care for individual patients with atopic dermatitis (AD).To describe treatment outcomes and to evaluate resource utilization and associated cost of maintenance use of tacrolimus ointment (MU) vs. standard use of tacrolimus ointment (SU) in adults with AD.A pan-European, phase III multicentre randomized clinical trial was conducted. Patients with mild to severe AD were randomized to tacrolimus 0.1% ointment (MU) or vehicle (SU) twice per week for 12 months. Disease exacerbations were treated by using open-label tacrolimus 0.1% ointment twice daily. Resource utilization data were collected prospectively alongside the clinical trial. Costs of pooled resource data were determined using German unit cost data. Direct and indirect costs were considered from third party payer, patient and societal perspectives.All patients with moderate and severe AD were included in a subanalysis, 75 patients in the MU arm (57% moderately affected) and 59 patients in the SU arm (59% moderately affected). In patients with moderate AD, the number of disease exacerbations in the MU arm was 2.4 vs. 5.5 in the SU arm (P<0.001); in patients with severe AD corresponding figures were 2.3 vs. 7.4 (P<0.001), respectively. Mean+/-SD total annual cost per patient was euro1525+/-1081 (MU) vs. euro1729+/-1209 (SU) in patients with moderate AD and euro2045+/-2013 (MU) vs. euro2904+/-1510 (SU) in patients with severe AD.Maintenance treatment with 0.1% tacrolimus ointment is more effective and leads to cost savings and improved health-related quality of life in comparison with standard use of 0.1% tacrolimus ointment, especially in patients with severe AD.
Financial Support by Spouse during Professional Education: Just Compensation at Divorce
Authors: William J. Curran
Journal: New England Journal of Medicine (1983)

It should have been expected. There have been a number of contested divorce cases in recent years in which the wage-earning spouse has requested compensation for contributing to the partner's professional education during the marriage. If one agrees with the justice of the claim, how much is it worth?Most of the high-court cases, but not all, have found that the spouse is entitled to compensation for her (or, if appropriate, his) financial and household support during the time the partner was being educated or trained. Two alternative measures of compensation have been applied: reimbursement for the expense of the . . .
Baby smile response circuits of the parental brain
Authors: James E. Swain, S. Shaun Ho
Journal: Behavioral and Brain Sciences (2010)

Abstract The parent-infant dyad, characterized by contingent social interactions that develop over the first three months postpartum, may depend heavily on parental brain responses to the infant, including the capacity to smile. A range of brain regions may subserve this social key function in parents and contribute to similar capacities in normal infants, capacities that may go awry in circumstances of reduced care.
Stromal cell–derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G0/G1 transition in CD34+ cells: evidence for an autocrine/paracrine mechanism
Authors: Jean-Jacques Lataillade, Denis Clay, Philippe Bourin, Françis Hérodin, Catherine Dupuy, Claude Jasmin, Marie-Caroline Le Bousse-Kerdilès
Journal: Blood (2002)
Identification of a point mutation in the adenosine deaminase gene responsible for immunodeficiency.
Authors: D T Bonthron, A F Markham, D Ginsburg, S H Orkin
Journal: Journal of Clinical Investigation (1985)

Deficiency of adenosine deaminase (ADA) is the cause of an autosomal recessive form of immunodeficiency. We sought to define, at a molecular level, the mutations responsible for ADA deficiency in the cell line GM-1715, derived from an immunodeficient patient. Full-length complementary DNA (cDNA) for ADA was synthesized and cloned from the cell line. Sequence analysis of the clones revealed a point mutation in codon 101 (CGG to CAG) that predicts an amino acid change from arginine to glutamine. Southern blot analysis, based on silent polymorphisms in the cDNA sequence, indicated that only one of the defective alleles of the GM-1715 line had been sequenced. The mutation that was identified appears to be responsible for the loss of function in this allele, since the predicted primary structure of the enzyme is otherwise entirely normal.
A Case of Hypertrophy of the Heart.
Authors: J. F. Jenkins
Journal: JAMA (1894)

Tecumseh, Mich., Oct. 4, 1894. <h3>To the Editor:</h3> —Oscar H., aged about 32 years, an American by birth, had his first attack of articular rheumatism when he was 16 years old, which left him with a damaged heart. Since that time he has had several severe attacks of rheumatic fever, each affecting more or less the circulation. The symptoms in his case were those associated with lesions of the semilunar valves of the aorta. Finally, death took place from "heart failure." October 4, forty-eight hours after death, a<i>post-mortem</i>examination was made by Drs. North and Teft, in the presence of Drs. Catlin, Howell, Woodward and Jenkins. Upon opening the thorax the heart was found greatly enlarged. A measurement of the heart before its removal from the cavity of the thorax gave the length seven and a half inches, breadth six inches, thickness four and a half inches, and its
The Theory and Therapy of Hyperkineses (Torticollis)
Authors: M. Mitscherlich
Journal: Psychotherapy and Psychosomatics (1979)

The paper presents the interaction approach in psychosomatics, as developed by the author. In this context the physical proceedings, which are oversome by the categories of the structure of space, differ from the psychic ones which are not of space but of time. The psyche itself is understood as an intentional experience, wherein the affects and unconscious proceedings are essential. Language has an important function. The psychosomatic disease is understood as a presentative symbolic event and as compensation for the loss of the cognitive ability to symbolize in the field of language. The problem of symbolization is illustrated by a case of spasmodic torticollis. The results of an examination of 81 patients are given, 23 of whom were treated psychoanalytically. The object relation, the regression to the pregenital level, the ego-regression in the form of the omnipotence of motion, and the inability for developing an own self are presented. An alternative technique of treatment is pointed out. Finally, the results of an examination of 26 cases of tic, including a case of generalized tic, are described.
HIGH PRESSURE POST-DILATATION PROCEDURE MAY INDUCE NEOINTIMAL COVERAGE AFTER SILOLIMS-ELUTING STENT IMPLANTATION
Authors: Masayuki Taniike, Masami Nishino, Takeshi Masaki, Naoki Mori, Daisuke Nakamura, Takahiro Yoshimura, Yasuharu Lee, Shimpei Nakatani, Masahiko Hara, Nobuhiko Makino, Yasuyuki Egami, Hiroyasu Kato, Ryu Shutta, Hitoshi Yamaguchi, Jun Tanouchi, Yoshio Yamada
Journal: Journal of the American College of Cardiology (2010)
Some properties of hemoglobin A<sub>2</sub>
Authors: Helen M. Ranney, Ruby Lam, Gwen Rosenberg
Journal: American Journal of Hematology (1993)

Abstract While no significant physiologic function of hemoglobin A 2 (Hb A 2 ), the minor basic component of human hemoglobin, has been recognized, only its oxygen equilibria have been studied in detail. Since hemoglobin A 2 and its oxidative denaturation product, hemichrome A 2 , bind to the red cell membrane, particularly to band 3, to a greater extent than do Hb A or hemichrome A, some of the properties of Hb A 2 that might influence hemoglobin‐membrane association were examined. Hemoglobin A 2 exhibited slightly increased susceptibility to autoxidation to methemoglobin. No differences were noted between methemoglobins A and A 2 , including the rates of enzymatic reduction and stability of the heme‐globin linkage. Oxyhemoglobin A 2 had a slightly lower solubility in phosphate buffer than did hemoglobin A. While the hemichromes (prepared with phenylhydrazine) of hemoglobins A 2 and A had the same optical spectra, the A 2 hemichrome exhibited greater stability. It is suggested that the differences in products of oxidative denaturation may provide the basis for functional differences between hemoglobins A 2 and A. © 1993 Wiley‐Liss, Inc.
Self-reported Exposure to Neurotoxic Chemical Combinations in the Gulf War&lt;subtitle&gt;A Cross-sectional Epidemiologic Study&lt;/subtitle&gt;
Authors: Robert W. Haley, Thomas L. Kurt
Journal: JAMA (1997)

To identify risk factors of factor analysis-derived Gulf War-related syndromes.A cross-sectional survey.A total of 249 Gulf War veterans from the Twenty-fourth Reserve Naval Mobile Construction Battalion.Participants completed standardized booklets measuring self-reported wartime exposures and present symptoms.Associations of factor analysis-derived syndromes with risk factors for chemical interactions that inhibit butyrylcholinesterase and neuropathy target esterase.Risk of syndrome 1 ("impaired cognition") was greater in veterans who reported wearing flea collars during the war (5 of 20, 25%) than in those who never wore them (7 of 229, 3%; relative risk [RR], 8.7; 95% confidence interval [CI], 3.0-24.7; P<.001). Risk of syndrome 2 ("confusion-ataxia") increased with a scale of advanced adverse effects from pyridostigmine bromide (chi2 for trend, P<.001), was greater among veterans who believed they had been involved in chemical weapons exposure (18 of 108, 17%) than in those who did not (3 of 141, 2%; RR, 7.8; 95% CI, 2.3-25.9; P<.001), and was increased in veterans who had been in a sector of far northeastern Saudi Arabia on the fourth day of the air war (6 of 21, 29%) than in those who had not been (15 of 228, 7%; RR, 4.3; 95% CI, 1.9-10.0; P=.004). Effects of perceived chemical weapons exposure and advanced adverse effects from pyridostigmine were synergistic (Rothman S, 5.3; 95% CI, 1.04-26.7). Risk of syndrome 3 ("arthro-myo-neuropathy") increased with an index of frequency and amount of government-issued insect repellent containing 75% DEET (N,N-diethyl-m-toluamide) in ethanol applied during the war (chi2 for trend, P<.001) and with advanced adverse effects from pyridostigmine (chi2 for trend, P<.001).Some Gulf War veterans may have delayed, chronic neurotoxic syndromes from wartime exposure to combinations of chemicals that inhibit butyrylcholinesterase and neuropathy target esterase.
Activation of β-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis
Authors: Mohammed Soutto, DunFa Peng, Ahmed Katsha, Zheng Chen, Maria Blanca Piazuelo, Mary Kay Washington, Abbes Belkhiri, Pelayo Correa, Wael El-Rifai
Journal: Gut (2014)

<h3>Objective</h3> In this study, we investigated the role of Trefoil factor 1 (TFF1) in regulating cell proliferation and tumour development through β-catenin signalling using <i>in vivo</i> and <i>in vitro</i> models of gastric tumorigenesis. <h3>Design</h3> <i>Tff1</i>-knockout (<i>Tff1</i>-KO) mice, immunohistochemistry, luciferase reporter, qRT-PCR, immunoblot, and phosphatase assays were used to examine the role of TFF1 on β-catenin signalling pathway. <h3>Results</h3> Nuclear localisation of β-catenin with transcriptional upregulation of its target genes, <i>c-Myc</i> and <i>Ccnd1</i>, was detected in hyperplastic tissue at an early age of 4–6 weeks and maintained during all stages of gastric tumorigenesis in the <i>Tff1</i>-KO mice. The reconstitution of TFF1 or TFF1 conditioned media significantly inhibited the β-catenin/T-cell factor (TCF) transcription activity in MKN28 gastric cancer cells. In agreement with these results, we detected a reduction in the levels of nuclear β-catenin with downregulation of <i>c-MYC</i> and <i>CCND1</i> mRNA. Analysis of signalling molecules upstream of β-catenin revealed a decrease in phosphorylated glycogen synthase kinase 3β (p-GSK3β) (Ser9) and p-AKT (Ser473) protein levels following the reconstitution of TFF1 expression; this was consistent with the increase of p-β-catenin (Ser33/37/Thr41) and decrease of p-β-catenin (Ser552). This TFF1-induced reduction in phosphorylation of GSK3β, and AKT was dependent on protein phosphatase 2A (PP2A) activity. The treatment with okadaic acid or knockdown of PP2A abrogated these effects. Consistent with the mouse data, we observed loss of TFF1 and an increase in nuclear localisation of β-catenin in stages of human gastric tumorigenesis. <h3>Conclusions</h3> Our data indicate that loss of TFF1 promotes β-catenin activation and gastric tumorigenesis through regulation of PP2A, a major regulator of AKT-GSK3β signalling.
Abstract OT2-3-02: NSABP B-43: A phase III clinical trial to compare trastuzumab (T) given concurrently with radiation therapy (RT) to RT alone for women with HER2+ DCIS resected by lumpectomy (Lx)
Authors: MA Cobleigh, SJ Anderson, TB Juilan, KP Siziopikou, DW Arthur, RA Rabinovitch, P Zheng, EP Mamounas, N Wolmark
Journal: Cancer Research (2013)

Abstract Background: A significant amount of DCIS is ER negative and/or overexpresses HER2. This provides an opportunity to test targeted therapy in DCIS. In xenograft models and cell lines, T boosts RT effectiveness. In T-treated HER2+ patients, apoptosis occurs within 1 wk of single agent T use, with T found in ductal aspirates. Ample safety evidence for T exists. T given during whole breast irradiation (WBI) may improve results for lumpectomy (Lx) resected HER2+ DCIS. A trial to examine this question will enhance the understanding of breast tumor biology and the prevention of such tumors and could possibly extend breast-conserving surgery benefits for women with DCIS. Method: After Lx for pure DCIS, each patient's DCIS lesion is centrally tested for HER2 by IHC analysis. HER2 2+ tumors undergo FISH analysis. HER2 3+ or FISH+ patients can be randomly assigned to 2 doses of T, 3 weeks apart during WBI or to WBI alone. Women ≥18 yrs. with a margin-clear Lx for pure DCIS, with ECOG status 0/1 who are clinically or pathologically node negative are eligible. Centrally tested DCIS must be HER2 +. ER and/or PR status must be known before randomization. Primary aims are to determine if T decreases ipsilateral breast cancer recurrence, ipsilateral skin cancer recurrence, or ipsilateral DCIS. Secondary aims are to determine the benefit of T in preventing regional or distant recurrence and contralateral invasive breast cancer or DCIS. NSABP B-43 will determine if DFS, recurrence-free interval, and OS can be improved with the use of T. 2000 patients will be accrued over 7.9 yrs, with a definitive analysis of primary endpoints performed at 163 ipsilateral breast cancer events (7.5 - 8 yrs. after protocol initiation) with an 80% power to detect a hazard reduction of 36%, from 1.73 ipsilateral breast cancer events per 100 pt-yrs to 1.11 events per 100 pt-yrs. The 36% observed reduction in the hazard of IIBCR-SCR-DCIS on the T arm is based on a projection of 40% hazard reduction if the compliance were perfect, with a 10% noncompliance rate. As of 5-31-13, 1,349 patients have been randomized. NCT00769379 Support: PHS NCI-U10-CA-69651, -12027; NCI P30-CA-14599; Genentech, Inc. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr OT2-3-02.
Mast cells, extracellular matrix components, TGFbeta isoforms and TGFbeta receptor expression in labial salivary glands in systemic sclerosis
Authors: G I Mason, J Hamburger, J B Matthews
Journal: Annals of the Rheumatic Diseases (2000)

To determine whether there was altered elaboration of non-collagenous extracellular matrix proteins or expression of TGFbeta isoforms and their receptors in salivary glands of patients with systemic sclerosis (SSc) and Raynaud's phenomenon (RP). Because of the possible role of mast cells in the early stages of SSc their presence was also investigated.Sections of normal labial salivary glands (n=10) and glands from patients with SSc (n = 13) and RP (n = 5) were stained immunohistochemically and using acid toluidine blue.SSc glands contained more mast cells than control tissues (p<0.005) and similar numbers to those found in RP specimens. There were no differences in the pattern or amount of non-collagenous matrix proteins detected. Tenascin and elastin were predominantly found surrounding ducts whereas fibronectin had a more general distribution. TGFbeta isoforms and receptors were expressed by glandular epithelium, fibroblasts, vascular endothelium and inflammatory cells. Cell counts showed no differences in expression of TGFbeta1 or TGFbeta receptors between groups. However, the percentage of TGFbeta2 positive fibroblasts was significantly higher in SSc glands compared with controls (p<0.004). RP glands showed an intermediate level of expression. By contrast, a lower percentage of RP fibrolasts expressed TGFbeta3 compared with controls with SSc glands showing an intermediate level of expression.These results show that (a) there are no changes in glandular expression of tenascin, elastin and fibronectin in SSc and RP and (b) both conditions are associated with an increased salivary gland mast cell population and changes in expression of TGFbeta2 and beta3 isoforms by glandular fibroblasts.
Aberrant DNA methylation is a dominant mechanism in MDS progression to AML
Authors: Ying Jiang, Andrew Dunbar, Lukasz P. Gondek, Sanjay Mohan, Manjot Rataul, Christine O'Keefe, Mikkael Sekeres, Yogen Saunthararajah, Jaroslaw P. Maciejewski
Journal: Blood (2008)
TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis. Effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines
Authors: W. Baumer, U. Seegers, M. Braun, T. Tschernig, M. Kietzmann
Journal: British Journal of Dermatology (2004)

Skin-infiltrating T cells play a predominant role in allergic and inflammatory skin diseases such as atopic dermatitis and allergic contact dermatitis. These T cells are attracted by chemotactic factors, e.g. RANTES (regulation on activation, normal T cell expressed and secreted; CCL5), TARC (thymus and activation regulated chemokine; CCL17) and CTACK (cutaneous T-cell attracting chemokine; CCL27).To investigate which T-cell-attracting chemokines are involved in allergic contact dermatitis in mice.Allergic contact dermatitis was induced by application of dinitrochlorobenzene (DNCB) or toluene-2,4-diisocyanate (TDI), and chemokine concentrations were determined by enzyme-linked immunosorbent assay. The effects on chemokine concentrations of the highly selective phosphodiesterase 4 inhibitor cilomilast and the glucocorticoid diflorasone diacetate were studied in mouse ears.RANTES and TARC were elevated in both models of allergic contact dermatitis 24 h after challenge, whereas CTACK remained unchanged. The increase in RANTES was diminished in mouse ears pretreated with cilomilast or diflorasone diacetate. TARC was reduced by diflorasone diacetate in the DNCB model but was highly induced in the TDI model; in contrast, TARC was not influenced by cilomilast.TARC and RANTES, but not CTACK, are involved in these two models of allergic contact dermatitis.
If a dog is tied to a bicycle
Authors: S. Ninan
Journal: BMJ (2012)

The senior house officer was fuming: “A&E! They’ve done it again! They’ve sent round an acute coronary syndrome who has blatantly got cholangitis.” He wasn’t prepared to let it go. “You’ve got to say something. This is a waste of our time and our bed.” It was clear that the patient’s initial working diagnosis was wrong and that he needed referral to the surgeons.

But there was little point in being upset; we have to accept that a certain portion of our referrals …
Thrombocytosis and spontaneous abortion
Authors: Fred Rosner, Hans W. Grünwald
Journal: American Journal of Hematology (1988)

Thrombocytosis and Spontaneous AbortionFalconer et al. [I] describe two cases of essential thrombocythemia (ET) in young women with recurrent spontaneous abortions, fetal growth retardation, and preeclampsia and suggest that anti-platelet drugs be given during pregnancy in such cases.The evidence for the diagnosis of ET in both patients is far from convincing and is limited to a high platelet count and an increase in megakaryocytes in the bone marrow.Both patients are exceptionally young for ET and neither patient has clinical evidence of bleeding nor leukocytosis.The first patient did not have splenomegaly and her platelet count was never greater than 854,000/dI.The second patient clearly had post-splenectomy thrombocytosis since her platelet count was normal prior to the removal of the spleen.It is possible that the hypothesis of Falconer et al. that high platelet counts may increase the risk of spontaneous abortion may be valid.It is also possible that the thrombocytosis occurred secondary to the abortion.In either event, the diagnosis of ET in their two patients cannot be made with certainty with the information presented.
Glossolalia and Single-Limb Trance: Some Parallels
Authors: Felicitas D. Goodman
Journal: Psychotherapy and Psychosomatics (1971)

In an earlier paper I was able to show that glossolalia was a trance produced behavior pattern. In the present report, on the basis of data from the anthropological literature and two personal observations, I am proposing that the single-limb trance of preliterate societies and the graphic automatism of literate ones is the same trance behavior. In the same manner as glossolalia, single-limb trance shows distinct characteristics depending on the energy level producing the manifestation. The graphic samples analyzed present a restricted inventory of shapes and the establishment of stereotypy, as well as a 'seepage' from the memory bank with the depletion of the energy level. However, single-limb trance does not result in the favorable subjective aftereffects reported from glossolalia.
TCT-444 Chronic Total Occlusion Lesion Revascularization Alone versus Complete Revascularization in Chronic Total Occlusion Patients with Multivessel Disease
Authors: Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Sung Il Im, Sun Won Kim, Jin Oh Na, Seong Woo Han, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2012)
Cardiogenic Shock Associated With Disopyramide Phosphate
Authors: Stephen T. Sinatra
Journal: JAMA (1980)

<h3>To the Editor.—</h3> We would like to support the article by Story and colleagues (242:654, 1979) concerning cardiogenic shock and disopyramide phosphate. We recently had a similar case in one of our patients. <h3>Report of a Case.—</h3> A 63-year-old man was taking digoxin and had a previous history of myocardial infarction. His condition was evaluated for dyspnea and fatigue. Physical examination demonstrated summation gallops and a grade 2 to 3 late systolic murmur. The chest roentgenogram showed cardiomegaly and a mild degree of interstitial prominence. The resting ECG showed sinus tachycardia, an intravenous conduction delay of the left bundle-branch in type, and frequent multifocal premature ventricular contractions. In the presence of high-grade ventricular arrhythmia with R-on-T phenomena and multifocal ectopic activity, the patient began receiving disopyramide phosphate, 100 mg orally three times a day. Approximately 48 hours later, the patient had extreme shortness of breath, came into the emergency room,