Treatment of Cyclophosphamide-Induced Cystitis with Prostaglandin E_2
Authors: J. MOHIUDDIN
Journal: Annals of Internal Medicine (1984)

Letters and Corrections1 July 1984Treatment of Cyclophosphamide-Induced Cystitis with Prostaglandin E2J. MOHIUDDIN, H.G. PRENTICE, S. SCHEY, H. BLACKLOCK, P. DANDONAJ. MOHIUDDINSearch for more papers by this author, H.G. PRENTICESearch for more papers by this author, S. SCHEYSearch for more papers by this author, H. BLACKLOCKSearch for more papers by this author, P. DANDONASearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-1-142_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: High-dose cyclophosphamide chemotherapy can be complicated by haemorrhagic cystitis, probably due to the effect of acrolein, a breakdown product, on the urothelium. The cystitis is occasionally fatal (1). The concurrent use of mesna (sodium 2-mercaptoethanesulphonate) has decreased the incidence of this complication (2). We report here the successful use of topical prostaglandin E2 (dinoprostone) in controlling severe chronic haemorrhagic cystitis after cyclophosphamide therapy to condition a bone marrow transplant recipient.An 18-year-old Iranian man had bone marrow transplantation for acute myeloid leukaemia during a refractory central nervous system relapse. On the fourth and third days before transplantation,...References1. BLACKLOCKBALLKNIGHTSCHEYPRENTICE HLCSG. Experience with mesna in patients receiving allogenic bone marrow transplants for poor prognostic leukaemia. Cancer Treat Rev. 1983;10(suppl A):45-52. CrossrefMedlineGoogle Scholar2. BRYANTJARMANFORTSMITH BMHI. Prevention of isophosphamide-induced urothelial toxicity with 2-mercaptoethane sulphonate sodium (mesnum) in patients with advanced carcinoma. Lancet. 1980;2:657-9. CrossrefMedlineGoogle Scholar3. EL-GENDINASSARTOPPOZADAABDEL-RAHEEM MSMF. Pharmacotherapeutics of prostaglandin E2 and 15(S) 15-methylprostaglandin F2 in chronic schistosomal bladder ulcer: a clinico-endoscopic study. Prostaglandins. 1982;24:97-104. CrossrefMedlineGoogle Scholar4. CHAUDHURYJACKSON TE. Prostaglandin cytoprotection of gastric mucosa. Gastroenterology. 1978;74:59-63. CrossrefGoogle Scholar5. FROLICHWILSONSWEETMAN JTB. Urinary prostaglandins: identification and origin. J Clin. Invest. 1975;55:763-70. CrossrefMedlineGoogle Scholar6. BROWNZENSERDAVIS WTB. Prostaglandin production by rabbit urinary bladder. Ann J Physiol. 1980;239:452-8. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Royal Free Hospital School of Medicine London NW3, 2QG United Kingdom PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAbsence of prostacyclin greatly relieves cyclophosphamide‐induced cystitis and bladder pain in miceHemorrhagic CystitisHemorrhagic CystitisThe management of cyclophosphamide-induced haematuriaPossible Contribution of Indomethacin to the Carcinogenicity of Nongenotoxic Bladder Carcinogens That Cause Bladder CalculiProtective Effect of Andrographis paniculata and Andrographolide on Cyclophosphamide-Induced Urothelial ToxicityAgents Acting on Prostanoid ReceptorsCistitis hemorrágica por poliomavirus bk y jc en pacientes sometidos a trasplante de médula ósea: aspectos clínicos y manejo urológicoExpression of inducible nitric oxide synthase in primary culture of rat bladder smooth muscle cells by plasma from cyclophosphamide-treated ratsThe management of intractable haematuriaCyclooxygenase-2Rehabilitation of prostate cancerRole of prostaglandins in the urinary bladder: an updateCyclooxygenase-2 is expressed in bladder during fetal development and stimulated by outlet obstructionEffective hyperbaric oxygenation with prostaglandin E1 for radiation cystitis and colitis after pelvic radiotherapyIntravesicular carboprost for the treatment of hemorrhagic cystitis after marrow transplantationHemorrhagic cystitis inbone marrow transplantationOral Conjugated Estrogen Therapy for Treatment of Hemorrhagic CystitisTreatment of Cyclophosphamide-Induced Hemorrhagic Cystitis with ProstaglandinsTreatment of Cyclophosphamide-Induced Intractable Hemorrhagic CystitisTreatment of Cyclophosphamide-Induced Hemorrhagic Cystitis with Intravesical Carboprost TromethamineSevere hemorrhagic cystitisHemorrhagic radiation cystitisProphylactic and Therapeutic Carboprost Tromethamine Bladder Irrigation in Rats with Cyclophosphamide-Induced Hemorrhagic CystitisIntravesical epsilon aminocaproic acid in management of intractable bladder hemorrhagePediatric Neoplastic DisordersThe Use of Prostaglandin F2 Alpha for the Prophylaxis of Cyclophosphamide Induced Cystitis in RatsEvaluation of carboprost tromethamine in the treatment of cyclophosphamide-induced hemorrhagic cystitisManagement of Complications of Cancer ChemotherapyHemorrhagic Cystitis: A ReviewProstaglandin E1 Bladder Instillations to Control Severe Hemorrhagic CystitisDrug Information Analysis ServiceUrological Complications of CyclophosphamideCyclophosphamide-induced bladder toxicity in wegener's granulomatosisCyclophosphamide-induced hemorrhagic cystitis: A review of 100 patientsProstaglandin F 2 -Alpha Bladder Irrigation for Control of Intractable Cyclophosphamide-Induced Hemorrhagic CystitisEicosanoid Synthesis by Human Urinary Bladder Mucosa: Pathological ImplicationsEvaluation of Misoprostol Cytoprotection of the Bladder with Cyclophosphamide (Cytoxan) TherapyThe effect of tiaprofenic acid and indomethacin on in vitro prostaglandin synthesis by rat, rabbit and human stomach tissueThe rat urinaryprostacyclin as well as other 1 July 1984Volume 101, Issue 1Page: 142-142KeywordsBone marrowBone marrow transplantationCentral nervous systemChemotherapyCyclophosphamideCystitisHigh-dose chemotherapyProstaglandinSodiumTransplantation Issue Published: 1 July 1984 PDF DownloadLoading ...