Isoniazid and Reaction to Cheese
Authors: C. KENT SMITH
Journal: Annals of Internal Medicine (1978)

Brief Reports1 April 1978Isoniazid and Reaction to CheeseC. KENT SMITH, M.D., F.A.C.P., DAVID T. DURACK, M.B., D.Phil., F.A.C.P., F.R.A.C.P.C. KENT SMITH, M.D., F.A.C.P., DAVID T. DURACK, M.B., D.Phil., F.A.C.P., F.R.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-88-4-520 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe first monoamine oxidase inhibitors used clinically were developed as congeners of isoniazid after mood elevation was noted in patients taking isoniazid for treatment of tuberculosis (1). Monoamine oxidase inhibitors are effective in the treatment of depression and certain phobic anxiety states, but their use is limited because hypertensive crises may occur when patients taking monoamine oxidase inhibitors eat foods rich in monoamines, especially tyramine (2). It is well known that certain cheeses and red wines may trigger this reaction (3). Although isoniazid is closely related structurally to some monoamine oxidase inhibitors, patients taking isoniazid are not regarded as being...References1. BYCK R: Drugs and the treatment of psychiatric disorders, in The Pharmacological Basis of Therapeutics, edited by GOODMAN LS, GILMAN A. New York, Macmillan Publishing Co., 1975, p. 152 Google Scholar2. HORWITZLOVENBERGENGELMANSJOERDSMA DWKA: Monoamine oxidase inhibitors, tyramine, and cheese. JAMA 188:1108-1110, 1964 CrossrefMedlineGoogle Scholar3. MARLEYBLACKWELL EB: Interactions of monoamine oxidase inhibitors, amines, and foodstuffs. Adv Pharmacol Chemother 8:185-239, 1970 CrossrefMedlineGoogle Scholar4. ZELLERBARSKYFOUTSKIRCHHEIMERVAN ORDEN EJJWL: Influence of isonicotinic acid hydrazide (INH) and 1-isonicotinyl-2-isopropyl hydrazide (IIH) on bacterial and mammalian enzymes. Experientia 8:349-350, 1952 CrossrefGoogle Scholar5. ROBINSONLOVENBERGKEISERSJOERDSMA DWHA: Effects of drugs on human blood platelet and plasma amine oxidase activity in vitro and in vivo. Biochem Pharmacol 17:109-119, 1968 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Duke University Medical Center Durham, North Carolina PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByDrug-Food InteractionsOfficial American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible TuberculosisFlu-like and Other Systemic Drug Reactions Among Persons Receiving Weekly Rifapentine Plus Isoniazid or Daily Isoniazid for Treatment of Latent Tuberculosis Infection in the PREVENT Tuberculosis StudyEarly Development of Monoamine Oxidase InhibitorsBiogenic Amines in FoodsIn Vitro , In Vivo , and Clinical Studies of Tedizolid To Assess the Potential for Peripheral or Central Monoamine Oxidase InteractionsPsychiatric Morbidity and Other Factors Affecting Treatment Adherence in Pulmonary Tuberculosis PatientsInfluence of fertilisation with foliar urea on the content of amines in wineDrug-Food InteractionsCurrent Knowledge about the Presence of Amines in WineAdverse reactions to first-line antituberculosis drugsIsoniazid and Food Interactions: —Fish, Cheese, and WineToxins in CheeseAmerican Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of AmericaClinically Significant Interactions with Drugs Used in the Treatment of TuberculosisIsoniazid Drug and Food InteractionsDrug Interactions with Antimicrobial AgentsAllergic reactions to foodsSignificance of biogenic amines to food safety and human healthAntitubercular drugsThe influence of food on the absorption and metabolism of drugsThe red face: Flushing disordersFactors Controlling Histamine Production in Swiss Cheese Inoculated with Lactobacillus buchneriAge and diet effects on drug actionNeurological Manifestations and Toxicities of the Antituberculosis DrugsCHEESE, WINE, AND ISONIAZIDUpdate of cardiovascular drug interactionsNutrient and Drug InteractionsNon-Immunologically-Mediated Food SensitivityMonoamine oxidase inhibitors and their pharmacological significanceOther Antibacterial DrugsEffects of Diet and Nutrition on Drug TherapyInteractions of Isoniazid with FoodsIs the failure of (-)deprenyl, a selective monoamine oxidase B inhibitor, to alleviate depression related to freedom from the cheese effect?Deprenyl in Parkinson's diseaseThe inhibition of tyramine oxidation and the tyramine hypertensive response (?cheese effect?) may be independent phenomenaRECENT CLINICAL STUDIES IN MONOAMINE OXIDASE INHIBITIONIsoniazid and Reaction to CheeseInteractions Between Drugs and NutrientsDrugs used in tuberculosis and leprosyAbsence of ?cheese effect? during deprenyl therapy: Some recent studies 1 April 1978Volume 88, Issue 4Page: 520-521KeywordsAnxietyCheesesEatingFoodIsoniazidMonoamine oxidase inhibitorsWine Issue Published: 1 April 1978 PDF DownloadLoading ...