tbuckley/cabot-search huggingface dataset:
Abstract 20028: Improved Outcomes with IT-enabled Care Management Following Coronary Revascularization
Authors: Daniel J Elliott, Paul Kolm, William Weintraub, Sharon Anderson, Patty Resnik, Terry Steinberg, Peggy Lynahan, Roger Kerzner
Journal: Circulation (2014)

Objective: Hospitals are increasingly responsible for the longitudinal care of patients discharged from their institution. We report preliminary results from an IT-enabled care management program for patients following coronary revascularization at a large regional medical center. Methods: The program consisted of patient education, telephonic management, and integration with community providers. The intensity of the intervention was tailored to patient risk of subsequent utilization. We used hierarchical logistic regression to compare severity-adjusted all-cause non-elective 30-day readmissions to our institution for all patients discharged in the first year (April 2013 - April 2014) with the baseline period (January 2010 - March 2013). We used mixed effects models to compare patient responses to the Care Transitions Measure-3 (CTM-3), a CMS-endorsed measure of transition quality, and the Seattle Angina Questionnaire-7 (SAQ-7) following discharge, both of which were collected as part of routine care management. Results: We enrolled 1,542 revascularized patients in the first year, including 1,188 with PCI and 354 with CABG. The overall rate of readmission for PCI was 7.5% in the baseline period and 8.0% in the intervention period. After adjusting for patient factors, the adjusted rate of readmission was 8.9% and 6.8% (adjusted RR 0.77 [0.76 - 0.78]). The unadjusted rates for CABG were 12.6 and 12.9; with adjusted rates of 13.3 and 10.8 in the baseline and intervention period, respectively (adjusted RR 0.81 [0.8 - 0.83]). The CTM-3 score improved from 67.4±13.3 to 78.8±16.8 for PCI and from 72.7±12.7 to 75±20.7 for CABG during the intervention period (p &lt; 0.001 for both). The SAQ domains all improved significantly during the course of the program, with improvements in Quality of Life Scale from 64±27 to 92±14 for PCI and 60±34 to 92±14 (p&lt;0.001). Conclusions: A care management program was associated with improved process and outcome measures, including significant improvements in patient-reported outcomes, when compared to historical controls. Interdisciplinary care management programs can play a significant role in improving care, including in non-integrated healthcare environments.
Who Is Who in Primary Vitreoretinal Lymphoma?
Authors: Andrés J. M. Ferreri
Journal: JAMA Oncology (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
At Pennsylvania Hospital, 250 Years of Care
Authors: M F Goldsmith
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2801: The use of induced pluripotent stem (iPS) cells for the safety testing of enhanced affinity TCR-transduced T cells
Authors: Katherine J. Adams, Andrew B. Gerry, Joanna E. Brewer, Nicholas J. Pumphrey, Alan D. Bennett, Bent K. Jakobsen
Journal: Cancer Research (2014)

Abstract Engineering T cells with enhanced affinity T cell receptors (TCRs) is a promising therapeutic strategy for treating cancer. Engineered TCRs overcome the limitations of naturally occurring cancer-antigen specific TCRs which are typically of extremely low affinity and fail to efficiently recognize tumor cells. However, the use TCRs with enhanced affinity for adoptive therapy carries with it the risk that they might recognize normal tissue, either as on-target or off-target reactivity. Two fatalities in a clinical trial of an affinity-enhanced MAGE-A3-specific TCR have highlighted the need for more biologically relevant cellular testing systems to minimize cross-reactivity-related toxicity in future adoptive immunotherapy trials. Cellular Dynamics International Inc. supply a range of iCell products that are highly pure induced pluripotent stem (iPS) cell-derived cells that reproduce normal human biology in an in vitro setting. The advantage of iCell cultures over standard cultures of primary cells is that they better represent human organs with respect to their antigen presentation by HLA. In this study, a panel of iCell sub-types, representing major organs of the human body, were used to test the reactivity of T cells transduced with an enhanced affinity TCR for HLA-A2-restricted peptide antigen NY-ESO-1/LAGE-1157-165. IncuCyte FLR technology, which enables direct visualization of caspase-3/7-dependent apoptosis at 37°C in real time, was used to assess the killing of the iCells by NY-ESO TCR-transduced T cells over a 4 day time course. While potent killing by the NY-ESO TCR-transduced T cells was observed against an HLA-A2+, NY-ESO-1+/LAGE-1+ tumor cell line, A375, no reactivity was observed against any of the tested iCells sub-types unless the iCells were pulsed with 1 µM NY-ESO peptide. The screening of TCR-transduced T cells against biologically appropriate cell cultures, such as iCells, further advances preclinical safety testing of new TCRs for use in adoptive immunotherapy. Citation Format: Katherine J. Adams, Andrew B. Gerry, Joanna E. Brewer, Nicholas J. Pumphrey, Alan D. Bennett, Bent K. Jakobsen. The use of induced pluripotent stem (iPS) cells for the safety testing of enhanced affinity TCR-transduced T cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2801. doi:10.1158/1538-7445.AM2014-2801
Treatment for Chronic Depression: Cognitive Behavioral Analysis System of Psychotherapy
Authors: Gary E Myers
Journal: BMJ (2001)

James P McCullough Jr 

Guilford Press, £24.95, pp 300

ISBN: 1 57230 527 4

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Poor response rates to drugs and psychotherapy make the treatment of chronic depression, which affects 50–75 million people in the United States alone, deeply frustrating for both patients and doctors. However, this book presents a promising new treatment. McCullough meticulously lays out the theory of the “cognitive behavioral analysis system of psychotherapy.” He uses numerous …

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Abstract 2080: Plasma membrane fluidity drives metastasis in breast cancer
Authors: Weina Zhao, Michael Tisza, Jessie Sjol, Sendurai Mani, Jeffrey T. Chang
Journal: Cancer Research (2014)

Abstract New therapeutic targets that can inhibit cancer metastasis are desperately needed. To address this issue, we have leveraged a computational approach and performed an unbiased screen for therapies that can inhibit an epithelial-to-mesenchymal transition (EMT) gene expression profile, a phenotype that is believed to promote metastases. This yielded predictions of drugs that can both promote and inhibit an EMT transcriptional profile. Following up on these predictions, we confirmed that these drugs can induce or repress an EMT in a range of breast cancer cell lines. Furthermore, we discovered that they do so by altering the fluidity of the plasma membrane. An increase in plasma membrane fluidity is necessary and sufficient to induce and maintain an EMT state, increased motility, and increased mammosphere forming ability. Finally, we found that human cancers can regulate their membrane fluidity through cholesterol homeostasis pathways. Human breast tumors with altered cholesterol profiles have a significantly shorter time to metastasis. These data demonstrate that plasma membrane fluidity is a cellular attribute that is leveraged by human tumors to increase metastatic capacity, and that it can, in principle, be targeted by therapeutics to prevent metastasis. Citation Format: Weina Zhao, Michael Tisza, Jessie Sjol, Sendurai Mani, Jeffrey T. Chang. Plasma membrane fluidity drives metastasis in breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2080. doi:10.1158/1538-7445.AM2014-2080
THE TREATMENT OF EMOTIONALLY INDUCED ILLNESS IN GENERAL MEDICAL PRACTICE BY AN AUDIOVISUAL TECHNIC
Authors: J A SCHINDLER
Journal: Annals of Internal Medicine (1955)

Article1 April 1955THE TREATMENT OF EMOTIONALLY INDUCED ILLNESS IN GENERAL MEDICAL PRACTICE BY AN AUDIOVISUAL TECHNICJOHN A. SCHINDLER, M.D., F.A.C.P.JOHN A. SCHINDLER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-4-909 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe Number One Problem in Contemporary Medicine: The contemporary physician is aware of two painful facts.The first is that emotionally induced illness comprises the bulk of medical practice. If the diagnosis of emotionally induced illness is confined to nonstructural illness, the incidence is around 30% of all patients seen.1 If the diagnosis is allowed to include structural change, the incidence is upward of 70%. Emotionally induced illness is thus by far the most important present day consideration in public health.The second fact is that the physician's treatment for this illness is easily the poorest he has to...Bibliography1. Schindler JA: The present status of therapy for emotionally induced illness, GP 9: 47-52 (Apr.) 1954. MedlineGoogle Scholar2. Mowrer OH: Neurosis: a disorder of conditioning of problem solving? Ann. New York Acad. Sc. 56: 273 (Feb.) 1953. CrossrefMedlineGoogle Scholar3. Schoben EJ: A learning theory interpretation of psychotherapy, Harvard Educational Review 18: 129-145, 1948. Google Scholar4. Saul LJ: Emotional maturity, 1947, J. B. Lippincott, Philadelphia. Google Scholar5. Salter A: Conditioned reflex therapy, 1949, Farrar & Straus, New York. Google Scholar6. English S: Personality manifestations in psychosomatic illness, 1953, Edward Stern and Company. CrossrefGoogle Scholar7. BowmanRose KMM: A criticism of the terms "psychosis," "psychoneurosis" and "neurosis," Am. J. Psychiat. 108: 161-166, 1951. CrossrefMedlineGoogle Scholar8. Noyes AP: Modern clinical psychiatry, 1953, W. B. Saunders Co., Philadelphia, p. 446-447. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Monroe, Wisconsin*Received for publication June 7, 1954. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byChanging Patterns of Medical PracticeDermatologic concepts and management of pruritus ani 1 April 1955Volume 42, Issue 4Page: 909-920KeywordsEmotionsPrevention, policy, and public health ePublished: 1 December 2008 Issue Published: 1 April 1955 PDF downloadLoading ...
After the Tests
Authors: Floyd Skloot
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mast cell infiltration and epithelial damage in children with episodic wheezing
Authors: Graziella Turato, Simonetta Baraldo, Elena Mutti, Emanuela Rossi, Erica Bazzan, Serena Calgaro, Deborah Snijders, Angelo Barbato, Marina Saetta
Journal: European Respiratory Journal (2013)

Rationale Wheezing is the most frequent clinical manifestation of asthma early in life, however is not specific since infants can have episodes of wheezing associated with viral infections. Neither the pathogenesis of these episodes nor their relation to classic asthma has been completely elucidated. Aim The aim of this study was to compare the airway pathology of children with wheezing only during viral infections i.e “episodic wheeze”, to that of children with wheezing not only during viral infections but also in between i.e.“multitrigger wheeze” that often evolves into asthma. Methods Bronchial biopsies were taken in 7 children with episodic wheeze, 18 with multitrigger wheeze and 7 controls who underwent bronchoscopy for appropriate clinical indications and analyzed by immunohistochemistry. Results Eosinophil infiltration was increased in multitrigger wheeze compared to controls (90;0-267 vs 9; 0-50 cells/mm2;p=0.007), but not in episodic wheeze (25;0-586). Mast cells were increased in the multitrigger and episodic wheeze groups (410; 113-755 and 460;183-750 cells/mm2) when compared to controls (144; 63-612; p=0.03). Epithelial damage was present in higher proportion in episodic and multitrigger wheeze children than in controls (65 vs 92% vs 37%) but the difference was not statistically significant. In the population as a whole, the number of mast cells positively correlated with the degree of epithelial damage (r=0.5, p=0.005). Conclusion The presence of mast cells along with epithelial damage might represent the anatomical basis for the intermittent wheezing in childhood. The presence of eosinophils along with mast cells might predispose to multitrigger wheeze in childhood and eventually asthma.
Secondary cancers after a carcinoid tumor of the lung: a population-based analysis.
Authors: Michele L. Cote, Angela S. Wenzlaff, Ann G. Schwartz
Journal: Cancer Research (2005)

478  Carcinoid lung tumors are relatively rare neoplasms of neuroendocrine origin. Prognosis is generally good, with the majority of patients receiving curative surgery. However, the etiology of carcinoid tumors of the lung is unclear, and it is unknown whether individuals are at greater risk of other cancers prior to or after their carcinoid tumor diagnosis. Lung carcinoid cases (n=2573) were identified from 12 Surveillance, Epidemiology and End Results registries from 1988-2001. Cases were predominately white (90.4%) and female (66.3%). Women were slightly older at diagnosis compared to men (60.7 and 57.9 years, respectively) and were more likely to be diagnosed with earlier stage tumors (p-value=0.004). Of lung carcinoid cases identified through SEER, 683 (26.5%) had at least one other cancer diagnosis. Thirty eight percent had a cancer diagnosis one year or more before their carcinoid diagnosis, 38% had a second cancer diagnosed within the same year, and 24% of individuals had another cancer diagnosed at least one year after their lung carcinoid. Records were available for 154 cancers from the 164 individuals who had a cancer diagnosed at least one year after their lung carcinoid. The distribution of cancers in the entire SEER population from 12 registries from 1988-2001 was used as the reference population. In women (n=98), the most common cancer diagnosed after a lung carcinoid was breast cancer (33.7%), similar to the female cancer distribution in the entire registry (31.5%). Cancers in women with differing distributions in the carcinoid subset compared to those in the SEER population included non-carcinoid lung cancer (18.4% and 11.9%, respectively), lymphomas (6.1% and 4.3%, respectively), and pancreas cancer (4.1% and 2.5%, respectively). In men (n=56), the most common cancer diagnosed after a lung carcinoid was prostate cancer (30.4%), similar to the cancer distribution among men in the SEER registry (30.1%). Unlike women, men with a prior lung carcinoid were less likely to be diagnosed with a non-carcinoid lung cancer (10.7%) afterwards, compared to all males in the SEER population (14.9%). Cancers in men with differing distributions in the carcinoid subset compared to those in SEER population included pancreas cancer (7.1% and 2.1%, respectively), melanoma (7.1% and 3.6%, respectively) and lymphomas (7.1% and 5.0%, respectively). Additional analyses, including standardized incidence ratios, will be presented. These findings may provide insight to etiologic factors associated with carcinoid tumors of the lung.
Endophthahiiitis Caused by the Coagulase-negative Staphylococci
Authors: L. David Ormerod, David D. Ho, Lynne E. Becker, Robert J. Cruise, H. Irene Grohar, Barbara G. Paton, Albert R. Frederick, Trexler M. Topping, John J. Weiter, Sheldon M. Buzney, Richard A. Ling, Ann S. Baker
Journal: Ophthalmology (1993)
Induction of permeability across endothelial cell monolayers by tumor necrosis factor (TNF) occurs via a tissue factor–dependent mechanism: relationship between the procoagulant and permeability effects of TNF
Authors: Josef Friedl, Markus Puhlmann, David L. Bartlett, Steven K. Libutti, Ewa N. Turner, Michael F. X. Gnant, H. Richard Alexander
Journal: Blood (2002)
Time trends in asthma and wheeze in Swedish children 1996–2006: prevalence and risk factors by sex
Authors: A. Bjerg, T. Sandström, B. Lundbäck, E. Rönmark
Journal: Allergy (2009)

Recent data suggest that the previously rising trend in childhood wheezing symptoms has plateaued in some regions. We sought to investigate sex-specific trends in wheeze, asthma, allergic conditions, allergic sensitization and risk factors for wheeze.We compared two population-based cohorts of 7 to 8-year olds from the same Swedish towns in 1996 and 2006 using parental expanded ISAAC questionnaires. In 1996, 3430 (97%) and in 2006, 2585 (96%) questionnaires were completed. A subset was skin prick tested: in 1996, 2148 (88%) and in 2006, 1700 (90%) children participated.No significant change in the prevalence of current wheeze (P = 0.13), allergic rhinitis (P = 0.18) or eczema (P = 0.22) was found despite an increase in allergic sensitization (20.6-29.9%, P < 0.01). In boys, however, the prevalence of current wheeze (12.9-16.4%, P < 0.01), physician-diagnosed asthma (7.1-9.3%, P = 0.03) and asthma medication use increased. In girls the prevalence of current symptoms and conditions tended to decrease. The prevalence of all studied risk factors for wheeze and asthma increased in boys relative to girls from 1996 to 2006, thus increasing the boy-to-girl prevalence ratio in risk factors.The previously reported increase in current wheezing indices has plateaued in Sweden. Due to increased diagnostic activity, physician diagnoses continue to increase. Time trends in wheezing symptoms differed between boys and girls, and current wheeze increased in boys. This was seemingly explained by the observed increases in the prevalence of risk factors for asthma in boys compared with girls. In contrast to the current symptoms of wheeze, rhinitis or eczema, the prevalence of allergic sensitization increased considerably.
Abstract 17409: Effects of Statin Therapy by Sex in a Meta-Analysis of Individual Patient Data from 169 139 Patients in the Cholesterol Treatment Trialists' Collaboration Study
Authors: Jordan Fulcher, Elizabeth Barnes, John Simes, Adrienne Kirby, Anthony C Keech
Journal: Circulation (2011)

Background: Statins have been shown to reduce cardiovascular risk and mortality, but the extent of their efficacy in women has been controversial. Objective: Using individual patient data, we aimed to assess statin efficacy overall and by sex. Methods: We analysed data from 26 randomised controlled trials assessing the effects of either statin vs. control or high dose statin vs. low dose statin on a series of prespecified CVD outcomes. Effects of statins on mortality and cardiovascular endpoints were expressed as the hazard ratio (HR, 95% CI for overall population/99% CI for subgroups) associated with a 1.0 mmol/L reduction of blood LDL-cholesterol achieved at 1 year. Results: Of 169 138 participants, 45 495 (27%) were female. Statin treatment significantly reduced the overall population risk for each CVD endpoint. Major coronary and major vascular events were significantly reduced overall and in both men and women, though the reductions with statin therapy were somewhat smaller in women (neither P for interaction reached the 1% level of significance). Death from CVD and all-cause mortality were significantly reduced overall and in men, but again the treatment-by-sex interaction tests were not significant at the 1% level. Numbers needed to treat to prevent a major vascular event for each 1.0 mmol/L LDL-cholesterol reduction with statin therapy for men and women, respectively, were 20 and 30 in secondary prevention, and 51 and 127 in primary prevention. There was no treatment effect on noncardiovascular death, cancer incidence or cancer death overall and in either sex. Conclusions: Both men and women benefit from reductions in major coronary and vascular events with statin therapy. The numbers needed to treat are higher for primary prevention, especially in women. Although mortality reductions are not independently significant in women, the balance of evidence supports routine statin therapy for individuals at risk of either sex.