tbuckley/cabot-search huggingface dataset:
Possible X-Linked Congenital Heart Disease
Authors: PATRICIA L. MONTELEONE, LEONARD F. FAGAN
Journal: Circulation (1969)

Four male members of a family are known to have congenital mitral and aortic insufficiency, a fifth male has congenital mitral insufficiency only, and a sixth male had congenital heart disease by history. The involved males comprised all males in three generations of this family. Chromosomal and dermatoglyphic studies of the two living affected males are normal. The involvement of males in this family is best explained on the basis of X-linked recessive inheritance. To our knowledge, this is the first report of possible X-linked inheritance of isolated congenital heart disease.
Impact of smoking habit on clinical outcomes after percutaneous coronary intervention
Authors: Dale T. Ashby, G. Dangas, M. Farkouh, I. Iakovou, G. Weisz, I. Hjazi, M. Adamian, E. Aymong, M. Mohamed, R. Mehran, G.W. Stone, A.J. Lansky, M. Collins, J. Moses, M.B. Leon
Journal: Journal of the American College of Cardiology (2002)
Professionalism and the Medical Student
Authors: Charles K. Francis
Journal: Annals of Internal Medicine (2004)

Editorials2 November 2004Professionalism and the Medical StudentCharles K. Francis, MDCharles K. Francis, MDFrom New York Academy of Medicine, New York, NY 10029.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-9-200411020-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail According to the Charter on Professionalism (1), 3 principles lie at the core of professionalism in medicine. The first principle, primacy of patient welfare, stresses altruistic dedication to the well-being of the individual patient. The second principle, patient autonomy, urges physicians to facilitate patient involvement in treatment decisions. The third core principle, social justice, calls upon physicians to work actively toward equitable societal distribution of health care resources.In the poignant essay “A Lesson from the Third Year” (2), which appears in this issue, a medical student caring for an elderly Chinese immigrant encounters each of the 3 core principles ...References1. Medical professionalism in the new millennium: a physician charter. Ann Intern Med. 2002;136:243-6. [PMID: 11827500] LinkGoogle Scholar2. Helms E. A lesson from the third year. Ann Intern Med. 2004;141:736-7. LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From New York Academy of Medicine, New York, NY 10029.Disclosures: None disclosed.Corresponding Author: Charles K. Francis, MD, New York Academy of Medicine, 1216 Fifth Avenue, New York, NY 10029; e-mail, [email protected]org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoA Lesson from the Third Year Eric Helms Bringing Professionalism to the Bedside Christine Laine and Harold C. Sox Professionalism and the Medical Student Nancy R. Angoff Metrics Cited ByEngaging Physicians and Consumers in Conversations About Treatment Overuse and WasteProfessionalism and the Medical StudentNancy R. Angoff, MD, MPH, MEdBringing Professionalism to the BedsideChristine Laine, MD, MPH, Senior Deputy Editor and Harold C. Sox, MD, Editor 2 November 2004Volume 141, Issue 9Page: 735-736KeywordsBehaviorConflicts of interestElderlyHealth careMedical dialysisMedical educationNursing homesPatientsRenal transplantation ePublished: 2 November 2004 Issue Published: 2 November 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
560 DIAGNOSTIC ACCURACY OF MULTIPLEX REAL-TIME PCR TEST KIT FOR DIAGNOSIS OF ACUTE HEPATITIS A AND CHRONIC HEPATITIS B AND CHRONIC HEPATITIS C
Authors: S.H. Lee, H.S. Kim, S.W. Jeong, S.G. Kim, J.Y. Jang, Y.S. Kim, B.S. Kim
Journal: Journal of Hepatology (2012)
Oesophageal pain in coronary artery disease
Authors: G GHILLEBERT, J JANSSENS
Journal: Gut (1998)

See article on page323 

Up to 26% of patients with angina-like chest pain sufficiently severe to necessitate more invasive examinations have normal coronary arteries on arteriography.1 Since the late 1970s, the oesophagus has gained notoriety as a possible cause of the chest pain in these patients. Depending upon the criteria used to accept an oesophageal origin of the pain, up to 50% of patients with normal coronary arteries have oesophageal pain. Gastroenterologists now widely accept that the best and possibly the only way to determine whether the oesophagus is the likely cause of the chest pain is to show a temporal correlation between the pain attack and an abnormal oesophageal event, such as acid reflux or severe motor disturbances.

Since the development of 24 hour pH and pressure measurements by the Leuven group, prolonged recordings have become a standard investigation in patients with non-cardiac chest pain.2 These measurements, which attempt to correlate symptoms with abnormal oesophageal events, led to the finding that most of the spontaneous pain attacks were reflux related, although many of these patients have a normal acid exposure on quantitative analysis of 24 hour …
Conduction Remodeling in Human End-Stage Nonischemic Left Ventricular Cardiomyopathy
Authors: Alexey V. Glukhov, Vadim V. Fedorov, Paul W. Kalish, Vinod K. Ravikumar, Qing Lou, Deborah Janks, Richard B. Schuessler, Nader Moazami, Igor R. Efimov
Journal: Circulation (2012)

Several arrhythmogenic mechanisms have been inferred from animal heart failure models. However, the translation of these hypotheses is difficult because of the lack of functional human data. We aimed to investigate the electrophysiological substrate for arrhythmia in human end-stage nonischemic cardiomyopathy.We optically mapped the coronary-perfused left ventricular wedge preparations from human hearts with end-stage nonischemic cardiomyopathy (heart failure, n=10) and nonfailing hearts (NF, n=10). Molecular remodeling was studied with immunostaining, Western blotting, and histological analyses. Heart failure produced heterogeneous prolongation of action potential duration resulting in the decrease of transmural action potential duration dispersion (64 ± 12 ms versus 129 ± 15 ms in NF, P<0.005). In the failing hearts, transmural activation was significantly slowed from the endocardium (39 ± 3 cm/s versus 49 ± 2 cm/s in NF, P=0.008) to the epicardium (28 ± 3 cm/s versus 40 ± 2 cm/s in NF, P=0.008). Conduction slowing was likely due to connexin 43 (Cx43) downregulation, decreased colocalization of Cx43 with N-cadherin (40 ± 2% versus 52 ± 5% in NF, P=0.02), and an altered distribution of phosphorylated Cx43 isoforms by the upregulation of the dephosphorylated Cx43 in both the subendocardium and subepicardium layers. Failing hearts further demonstrated spatially discordant conduction velocity alternans which resulted in nonuniform propagation discontinuities and wave breaks conditioned by strands of increased interstitial fibrosis (fibrous tissue content in heart failure 16.4 ± 7.7 versus 9.9 ± 1.4% in NF, P=0.02).Conduction disorder resulting from the anisotropic downregulation of Cx43 expression, the reduction of Cx43 phosphorylation, and increased fibrosis is likely to be a critical component of arrhythmogenic substrate in patients with nonischemic cardiomyopathy.
Rapid, Guanosine 5'‐Diphosphate‐Induced, Gelation of Chitosan Sponges as Novel Injectable Scaffolds for Soft Tissue Engineering and Drug Delivery Applications
Authors: Mina Mekhail, Jamal Daoud, Guillermina Almazan, Maryam Tabrizian
Journal: Advanced Healthcare Materials (2013)

Novel injectable chitosan sponges based on rapid ionic crosslinking using guanosine 5'-diphosphate are introduced. The rapid gelation, high water retention, desirable physicochemical properties, soft tissue-like mechanical properties, and excellent cytocompatibility make these injectable sponges promising candidates for tissue regeneration and drug delivery applications.
Evaluation of a new immortalized human fetal liver cell line (cBAL111) for application in bioartificial liver
Authors: Paul P.C. Poyck, Albert C.W.A. van Wijk, Tessa V. van der Hoeven, Dirk R. de Waart, Robert A.F.M. Chamuleau, Thomas M. van Gulik, Ronald P.J. Oude Elferink, Ruurdtje Hoekstra
Journal: Journal of Hepatology (2007)
330. Lentiviral Vector Mediated Hematopoietic Stem Cell Gene Therapy Combined with Non-Lethal Conditioning Restores T Cell Function in the Murine Model of Wiskott-Aldrich Syndrome
Authors: Francesco Marangoni, Loïc Dupré, Samantha Scaramuzza, Sara Trifari, Raisa Jofra Hernández, Adrian Thrasher, Anne Galy, Alessandro Aiuti, Luigi Naldini, Maria Grazia Roncarolo
Journal: Molecular Therapy (2005)
Reconstructive surgery versus nephrectomy in renal artery stenosis: comparison of effects on total and divided renal function and on blood pressure.
Authors: A Mackay, J J Brown, A F Lever, J I Robertson
Journal: BMJ (1980)

Twenty-six hypertensive patients with unilateral renal artery disease and normal overall renal function were treated surgically: eleven underwent arterial reconstruction and 15 unilateral nephrectomy. One year after operation there was similar reduction in blood pressure in each group (delta mean BP 45:3 mm Hg (p &lt; 0.001) and 36.8 mm Hg (p &lt; 0.001) respectively. contrary to previous reports, however, a small but significant improvement in overall renal function was observed in patients who underwent reconstructive surgery (delta mean serum creatinine--13.3 mumol/1 (p &lt; 0.01); this was associated with a significant rise in para-aminohippurate (PAH) clearance in the operated kidney, while PAH clearance fell on the contralateral side. Overall renal function deteriorated in the patients who underwent unilateral nephrectomy (delta mean serum creatinine +22.7 mumol/1 (p &lt; 0.01)). The latter was due partly to diminished clearance in the remaining kidney and partly to the loss of the excised kidney. The findings emphasise the superiority of renal artery reconstruction over nephrectomy in patients with renovascular hypertension.
T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation
Authors: Sarah E Henrickson, Thorsten R Mempel, Irina B Mazo, Bai Liu, Maxim N Artyomov, Huan Zheng, Antonio Peixoto, Michael P Flynn, Balimkiz Senman, Tobias Junt, Hing C Wong, Arup K Chakraborty, Ulrich H von Andrian
Journal: Nature Immunology (2008)
Berta (“Betty”) Gol
Authors: Ruth Foist
Journal: BMJ (2006)

​FormerFormer general practitioner Kingsbury, Warwickshire (b 1914; q Prague 1938), died from bowel cancer on 24 December 2005.




Figure 1




Berta (“Betty”) left Nazi occupied Prague in 1939 and travelled to Palestine, where she joined the British army's medical corps. During this journey she met her husband, Joseph Gol. After the war they returned to Prague, where they raised two children and Betty practised medicine, specialising in gynaecology. When Prague was again occupied in 1968 they moved to England. Betty restarted her medical training, becoming a general practitioner. She remained a partner until retirement in 1983 and worked as a locum until the age of 79. Predeceased by her husband in 1981, she leaves two children and six grandchildren.
Lupoid Hepatitis: A Nonentity in the Spectrum of Chronic Active Liver Disease?
Authors: R. D. Soloway
Journal: Annals of Internal Medicine (1972)

Meeting Abstracts1 May 1972Lupoid Hepatitis: A Nonentity in the Spectrum of Chronic Active Liver Disease?R. D. Soloway, M.D., W. H. J. Summerskill, M.D., F.A.C.P., A. H. Baggenstoss, M.D., L. J. Schoenfield, F.A.C.P.R. D. Soloway, M.D.Search for more papers by this author, W. H. J. Summerskill, M.D., F.A.C.P.Search for more papers by this author, A. H. Baggenstoss, M.D.Search for more papers by this author, L. J. Schoenfield, F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-5-861_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo define the features of "lupoid" hepatitis, we analyzed data from 88 consecutive patients with chronic active liver disease, selected prospectively by precisely predefined clinical, biochemical, and histologic criteria (Gastroenterology60:167, 1971) and without reference to the result of the lupus erythematosus (LE) test. All were then randomized to treatment with prednisone, azathioprine, or both, or placebo. Therefore, our 6-monthly reevaluation included standard tests and liver biopsy. Initially, 30 patients were positive (LE+) and 58 negative (LE-). The LE+ patients were characterized significantly (P< 0.05) by disease of shorter duration—more frequent hepatomegaly and splenomegaly; higher serum bilirubin, serum glutamic-oxalacetic... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Rochester, Minn. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHistorical reflections on autoimmune hepatitis 1 May 1972Volume 76, Issue 5Page: 861-861KeywordsBilirubinBiopsyHepatitisHepatitis AHepatomegalyLiverLiver diseasesLupus erythematosusSplenomegaly Issue Published: 1 May 1972 PDF DownloadLoading ...
An Unusual Neurologic Syndrome Associated with Hyperserotonemia
Authors: A. L. Southren, R. R. P. Warner, N. I. Christoff, H. E. Weiner
Journal: New England Journal of Medicine (1959)

THE finding of serotonin (5-hydroxytryptamine) in the brains of rats by Twarog and Page1 initiated a series of experiments and conjectures concerning its role in the central nervous system.2 3 4 5 The accumulated evidence indicates that serotonin has an important function in cerebral metabolism, although its mode of action is so far unclear. Regarding its site of action in the brain, Amin et al.,6 Bogdansky and Udenfriend7 and Gaddum and Giarman8 showed that serotonin and the enzymes necessary to produce and metabolize it are found in highest concentrations in the hypothalamus, an area associated with the central autonomie nervous system.During an . . .
The cost of liver disease in Korea: methodology, data, and evidence
Authors: Wankyo Chung
Journal: Clinical and Molecular Hepatology (2015)

Background/Aims This study introduces methods for estimating the cost of liver disease and presents useful and reliable sources of data. The available evidence on the costs associated with liver disease is also discussed. Methods Costing methodology can be used to identify, measure, and value relevant resources incurred during the care of patients with liver diseases. It adjusts for discounting, skewed distribution, and missing or censored cost data. The human capital approach for productivity cost assumes that deceased patients would have lived to a normal expected life expectancy, and have earned a salary in line with the current age profile of wages, in order to measure potential earnings lost due to premature death or job loss. Evidence The number of deaths due to liver cancer (C22) increased from 6,384 in 1983 to 11,405 in 2013, while deaths due to other liver diseases (K70-K76) increased from 12,563 in 1983 to 13,458 in 1995, and then declined to 6,665 in 2013. According to the Global Burden of Disease study conducted by the World Health Organization, liver cancer caused 325,815 disability-adjusted life years (DALYs), and cirrhosis of the liver caused 206,917 DALYs in 2012. The total cost of liver disease was estimated at 1,941 billion Korean won in 2001 and 5,689 billion Korean won in 2008. Much of this cost is attributable to productivity cost, and especially that of economically active men. Conclusions The economic burden of liver disease is immense because of the associated high mortality and morbidity, especially among the economically active population. This indicates the need to prioritize the development of appropriate health interventions. Keywords: Cost of illness; Liver disease
A computational approach to the description of individual immune responses.
Authors: I. Søndergaard, L. Kærgaard Poulsen, O. ØSterballe, B. Weeke
Journal: Allergy (1991)

Detailed evaluation of the IgE and IgG‐subclass immune response during immunotherapy can now be performed by crossed radio immunoelectrophoresis (CRIE). Some new concepts are introduced facilitating the handling of the vast amount of data obtained by quantitating the immune response. These concepts are “distance” between antibody responses and “immune response width”. The 20 patients included in this study were pollen‐allergic patients who underwent specific immunotherapy in a 3‐year prospective study. It was found that the immune response during immunotherapy was restricted to IgG 1 and IgG 4 antibodies. The semi‐quantitative CRIE analysis correlated with the RAST analysis for the IgE samples before start of immunotherapy, for the IgG 1 samples at week 12, and for all the IgG 4 samples. During immunotherapy the number of IgG 1 antibodies directed to the different antigens increased towards 11 antigens and decreased towards six. For the IgG 4 antibodies the number of reactions increased towards 15 antigens and decreased towards four. The increase is generally paralleled by an increase in the quantitative immune response as well. For some of the antigens a rise in the IgE antibodies is contrasted by a fall in the IgG 4 antibody response, and for other antigens the opposite was true, indicating a regulatory mechanism between the IgE and the IgG 4 synthesis. The IgE immune response to a number ively diminished during the period of immunotherapy when IgG 1 was present early (week 12) in the period, and for other antigens there was a rise in IgE without an early IgG 1 antibody response. This suggests that IgG 1 can have a regulating influence on the IgE synthesis. Finally, we have found that IgE antibodies with specificities not present in the samples taken before immunotherapy were formed during immunotherapy. These new IgE antibodies do not, however, seem to impair the outcome of treatment.
In vivo anti-tumor effect of dual release of cisplatin and adriamycin from biodegradable gelatin hydrogel
Authors: Mitsunaga Konishi, Yasuhiko Tabata, Masatoshi Kariya, Hossein Hosseinkhani, Ayako Suzuki, Ken Fukuhara, Masaki Mandai, Kenji Takakura, Shingo Fujii
Journal: Journal of Controlled Release (2004)
Corynoxine isomers decrease levels of amyloid-β peptide and amyloid-β precursor protein by promoting autophagy and lysosome biogenesis
Authors: Siva Durairajan, Yingyu Huang, Leilei Chen, Juxian Song, Liangfeng Liu, Min Li
Journal: Molecular Neurodegeneration (2013)

Background One of the key histopathological features of Alzheimer’s disease (AD) is the formation of neuritic plaques characterized by accumulation of amyloid b-peptide (Ab) derived from amyloid precursor protein (APP). Impairment of the autophagy-lysosomal degradation pathway has been associated with AD. Recently we have identified a novel natural autophagy inducer, corynoxine B (Cory-B), a major oxindole alkaloid from the Chinese medicinal plant Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese). In this study, we have also established that corynoxine (Cory) and its isomer of Cory-B, not only increases basal level of autophagy but also increases the lysosomal activity in neuronal cell lines. Interestingly Cory but not Cory-B showed the enhanced lysosomal activities.
Abstract 4252: Mechanistic and clinical implications of epigenetic modulation in liver cancer stem cells
Authors: Jens U. Marquardt, Chiara Raggi, Jesper B. Andersen, Deakwan Seo, Itzhak Avital, Agnes Holczbauer, Valentina M. Factor, Snorri S. Thorgeirsson
Journal: Cancer Research (2010)

Abstract Epigenetic mechanisms play critical roles in both stem cell and cancer biology. Epigenetic modulation directs stem cells towards pluripotency and promotes differentiation of more mature derivatives. We hypothesized, that if similar mechanisms are relevant to the cancer stem cell (CSC) model, then epigenetic modulation might enrich the CSC population, thereby facilitating CSCs isolation and rigorous evaluation. Five hepatoma cell lines were treated with Zebularine (ZEB), an effective DNMT1-inhibitor. Putative CSC were isolated using the “side population” (SP) approach. FACS-sorted SP and non-SP fractions were examined for tumorigenic capacity and differences in gene expression. SP-derived signatures were integrated with HCC microarray database and tested for a prognostic value. ZEB-treatment significantly reduced the SP size while remarkably increasing the proportion of cells with CSC properties as judged by a superior tumor-initiation capacity relative to the untreated SP cells. This was further confirmed in serial transplantation as well as direct cell tracking experiments using genetically labeled SP and non-SP cells. Furthermore, integrative transcriptome analysis of the ZEB-enriched CSC populations identified common stemness traits although various oncogenic pathways (e.g. EGFR, SRC and MYC) were activated in individual hepatoma cell lines. Moreover, each individual as well as the common CSC signatures were associated with poorly differentiated tumors, high recurrence rate and poor survival in liver as well as lung cancers. In conclusion, we demonstrate that modulation of the liver cancer epigenome is a useful tool to increase the representation of highly tumorigenic cells with CSC properties within the SP fraction. The integrative analysis of the CSC transcriptome revealed a pernicious interaction of common CSC stemness genes with variety of known oncogenic pathways in liver cancer. The significance of CSC- enriched gene signature for the prognosis of liver and other cancers provides a rationale for therapeutic targeting of CSCs. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4252.
Abstract 4069: 2-deoxyglucose and compound C reversed acidification but enhanced growth inhibition in colon cancer cells treated with metformin and phenformin
Authors: Michael A. Lea, Jerel Chako, Sandhya Bolikal, Ji-Young Hong, Ryan Chung, Andres Ortega, Charles desBordes
Journal: Cancer Research (2011)

Abstract A report that effects of butyrate on some cells may be mediated by activation of AMP-dependent kinase (AMPK) prompted us to examine if other AMPK activators can induce differentiation and inhibit proliferation of colon cancer cells in a manner similar to butyrate. Using induction of alkaline phosphatase as a marker, we observed that compound C, an AMPK inhibitor, could decrease the differentiating effect of butyrate or valproate on SW1116 and Caco-2 colon cancer cells. On the other hand, A769662, an activator of AMPK did not increase alkaline phosphatase activity and decreased the induction seen with butyrate. Metformin was observed to be less effective than butyrate in the induction of alkaline phosphatase but was more effective as a growth inhibitor. Phenformin was found to be a more potent growth inhibitor than metformin and both compounds cause acidification of the medium when incubated with colon cancer cells. pH changes were monitored with a pH electrode and by the decrease in absorbance of phenol red at 560 nm. Coincubation with compound C decreased the acidification caused by the biguanides. Combined incubation of 2-deoxyglucose with either of the biguanides prevented the acidification of the medium but enhanced the growth inhibitory effects. Growth inhibitory effects of biguanides appeared less with a tetrazolium reduction assay than with thymidine incorporation but supported the conclusion that combination with 2-deoxyglucose could increase growth inhibition caused by biguanides. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4069. doi:10.1158/1538-7445.AM2011-4069