AN EVALUATION OF SULFONAMIDE MIXTURES AND VARIOUS ADJUVANTS FOR CONTROL OF SULFONAMIDE CRYSTALLURIA
Authors: H F FLIPPIN, J G REINHOLD
Journal: Annals of Internal Medicine (1946)

Article1 September 1946AN EVALUATION OF SULFONAMIDE MIXTURES AND VARIOUS ADJUVANTS FOR CONTROL OF SULFONAMIDE CRYSTALLURIAHARRISON F. FLIPPIN, M.D., F.A.C.P., JOHN G. REINHOLD, Ph.D., LILLIAN POLLACK, ELAINE CLAUSEN, B.A.HARRISON F. FLIPPIN, M.D., F.A.C.P.Search for more papers by this author, JOHN G. REINHOLD, Ph.D.Search for more papers by this author, LILLIAN POLLACKSearch for more papers by this author, ELAINE CLAUSEN, B.A.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-3-433 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRenal complications due to sulfonamide therapy continue to be among the most frequent and serious attending the use of these drugs.1, 2, 3Two main causes are established: (1) irritation due to formation in the kidneys or ureters of crystals largely of the acetylated drug and (2) nephrotoxic action. The causes of the latter are poorly understood. However, there is ample evidence to show that crystalluria is the result of the very low solubility of the acetylated drugs in urine that is acid in reaction.4, 5, 6, 7, 8Despite numerous demonstrations of the effectiveness of alkalinization6, 9, 10, 11,...Bibliography1. SIMON MA: Pathologic lesions following the administration of sulfonamides, Am. Jr. Med. Sci., 1943, ccv, 439. Google Scholar2. SWARTZ P: Toxic effect of sulfonamide therapy on urinary tract, Canad. Med. Assoc. Jr., 1944, l, 440. Google Scholar3. MURPHY FD: Diseases of the kidney in The cyclopedia of medicine and surgery-service, 1945, F. A. Davis Co., Philadelphia, p. 320. Google Scholar4. SUNDERMANPEPPERBENDITT FWDSE: Sulfathiazole in blood and urine, Am. Jr. Med. Sci., 1940, cc, 790. CrossrefGoogle Scholar5. JENSENFOX OJCL: Hydrogen ion concentration and the solubility of sulfonamides in urine: the relation to renal precipitation, Jr. Urol., 1943, xlix, 334. CrossrefGoogle Scholar6. GILLIGANGARBWHEELERPLUMMER DRSCN: Adjuvant alkali therapy in the prevention of renal complication from sulfadiazine, Jr. Am. Med. Assoc., 1943, cxxii, 1160. CrossrefGoogle Scholar7. WELCHMATTISLATVENBENSONSHIELS ADPAARWMEH: Sulfamerazine (2-sulfanilamido-4-methylpyrimidine). 1. A comparison of sulfamerazine with sulfadiazine on the basis of absorption, excretion and toxicity, Jr. Pharmacol. and Exper. Therap., 1943, lxxvii, 357. Google Scholar8. BARNESKAWAICHI RWK: Factors influencing the formation of sulfonamide urinary concretions, Jr. Urol., 1943, xlix, 324. CrossrefGoogle Scholar9. SCHWARTZFLIPPINREINHOLDDOMM LHFJGAH: The effect of alkali on crystalluria from sulfathiazole and sulfadiazine, Jr. Am. Med. Assoc., 1941, cxvii, 514. CrossrefGoogle Scholar10. CLIMENKOBARLOWWRIGHT DRCWAW: Influence of sodium bicarbonate in preventing renal lesions from massive doses of sulfathiazole, Arch. Path., 1941, xxxii, 889. Google Scholar11. FOXJENSENMUDGE CLOJBH: The prevention of renal obstruction during sulfadiazine therapy, Jr. Am. Med. Assoc., 1943, cxxi, 1147. CrossrefGoogle Scholar12. GRIEP AH: Note on alkalinization during sulfonamide therapy, Univ. Hosp. Bull., Ann Arbor, 1944, x, 44. Google Scholar13. ROSENBLATTGRAYZEL PDM: Renal lesions in sulfonamide intoxication, Urol. and Cutan. Rev., 1944, xlviii, 556. Google Scholar14. LEHR D: Inhibition of drug precipitation in the urinary tract by the use of sulfonamide mixtures. I. Sulfathiazole-sulfadiazine mixture, Proc. Soc. Exper. Biol. and Med., 1944, lviii, 11. Google Scholar15. LEHR D: The prevention of renal complications by the therapeutic employment of sulfonamide mixtures. I. Sulfathiazole-sulfadiazine mixture, Jr. Urol., 1946, lv, 548. CrossrefGoogle Scholar16. FEINSTONEWILLIAMSWOLFFHUNTINGTONCROSSLEY WHRDRTEML: The toxicity, absorption and chemotherapeutic activity of 2-sulfanilamido pyrimidine (sulfadiazine), Bull. Johns Hopkins Hosp., 1940, lxvii, 427. Google Scholar17. SOBINARONBERGROLNICK SSLMHC: Nature of renal lesion with sulfonamides and its prevention with urea, Am. Jr. Path., 1943, xix, 211. Google Scholar18. LEHR D: Treatment of experimental renal obstruction from sulfadiazine. 1. Forcing of fluids and alkalinization, Proc. Soc. Exper. Biol. and Med., 1944, lvi, 82. CrossrefGoogle Scholar19. REINHOLDFLIPPINDOMMZIMMERMANSCHWARTZ JGHFAHJJL: Renal clearances of sulfamerazine, sulfadiazine, sulfathiazole, and sulfapyridine in man, Jr. Pharmacol. and Exper. Therap., 1945, lxxxiii, 279. Google Scholar20. OHNYSTYWOLFSON JWQ: Potassium bicarbonate: An adjunct to chemotherapy in pneumonia complicating cardiac decompensation, New England Jr. Med., 1944, ccxxxi, 381. CrossrefGoogle Scholar21. LAM RL: Use of potassium bicarbonate as adjuvant alkali therapy with sulfonamides: Preliminary report, Univ. Hosp. Bull., Ann Arbor, 1944, x, 86. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Read at the Twenty-Seventh Annual Session, American College of Physicians, Philadelphia, May 17, 1946.From the Committee on Chemotherapy and the Division of Biochemistry, Philadelphia General Hospital.This work was aided by a grant from the Research Fund for Infectious Diseases, University of Pennsylvania, Philadelphia.†Clinical facilities were given us for this study by the following chiefs of service: Drs. Frieda Baumann, R. A. Boles, C. L. Brown, Thomas Klein, D. W. Kramer, D. W. Kremer, W. B. Leaman, Jr., S. A. Loewenberg, and T. G. Schnabel. 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GREENEBAUM, M.D.Chemotherapeutics and antibiotics in dentistryTreatment of Renal InsufficiencyRecent Trends in the Treatment of Infectious DiseasesPrevention of Renal Complications by the Use of Sulfonamide MixturesLobar Pneumonia 1 September 1946Volume 25, Issue 3Page: 433-442KeywordsDrug therapyDrugsFeversInfectious diseasesKidneysResearch fundingResearch grantsSulfonamideUreterUrine Issue Published: 1 September 1946 PDF downloadLoading ...