tbuckley/cabot-search huggingface dataset:
Abstract 4778: Epigenetic modulation of colorectal cancer cells for cancer-testis antigen-targeted immunotherapy
Authors: Jeffrey Chou, Lilien N. Voong, Xiaoji Chen, Cassian Yee, Edus H. Warren
Journal: Cancer Research (2010)

Abstract Cancer-testis (C-T) antigens represent attractive potential targets for cancer immunotherapy due to their limited expression in normal somatic tissues and their widespread expression in malignant cells of diverse histologies. The utility of C-T antigens for immunotherapy of colorectal cancer (CRC), however, is limited because expression of C-T genes is repressed in most CRC cells by hypermethylation. We investigated whether treatment of CRC lines with the hypomethylating agent 5-aza-2′-deoxycytidine (DAC) could induce C-T gene expression in CRC cells and thereby sensitize them to recognition by CD8+ cytotoxic T lymphocytes (CTL) specific for the highly immunogenic C-T antigen NY-ESO-1. A panel of CRC and primary dermal fibroblast lines was cultured with DAC or medium alone for 48 hours followed by culture with exposure to interferon γ (IFNγ) or medium alone for an additional 48 hours. After the treatment period, cells were harvested for collection of RNA, DNA, and protein; studied with flow cytometry for analysis of MHC class I and II expression; and tested for recognition by HLA-A*0201-restricted CTL specific for NY-ESO-1157–165 in a 51Cr release-cytotoxicity assay. Quantitative RT-PCR analysis of the expression of 20 C-T genes in untreated and DAC-treated cells using a custom PCR array showed that the majority of C-T genes were expressed at low levels in untreated CRC cells but were induced in most CRC cell lines by DAC exposure. Fibroblasts did not show any significant C-T gene expression with or without DAC treatment. Western blot analysis for NY-ESO-1 expression confirmed that DAC induction of NY-ESO-1 transcription was also associated with increased protein expression. DAC-treated HLA-A*0201+ CRC lines were also recognized by CD8+ HLA-A*0201-restricted NY-ESO-1-specific CTL. CTL recognition was enhanced when the cells were treated with IFNγ in combination with DAC, with the most significant effect seen in CRC cells with low baseline expression of MHC class I molecules. These data suggest that epigenetic modulation with DAC or related agents could be used to selectively induce expression of C-T antigens in CRC cells and thereby make them susceptible to C-T antigen-directed immunotherapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4778.
Fruit Extract for PMS
Authors: Joan Stephenson
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE IMPORTANCE OF METHOD IN THE ISOLATION OF PATHOGENIC ORGANISMS OF THE TYPHOID GROUP FROM FAECES: A Further Note on the Value of Telluric Acid Combined with Brilliant Green
Authors: C. H. Browning, L. H. D. Thornton
Journal: BMJ (1916)

PATHOGENIC ORGANISMS FROM FAECES. [AY 13, x916 tlheorqtically the nutrition of the foot must go wrrong, is too horrible to be contemplated.Actual experience has proved thiat, in-many cases, thle errors of nutrition which ouglht in theory to 6ceur do not occur, or, at worst, are pot neailv so serious as might be expected.CoN CLUSIoN.Surgeons will glean from whlat has been written that tlhere are many ways in whiclh -tlhe disabilities following nierve destruction can be met, and that lhardly any case is bad enougl to justify a counsel of despair.Our know- * Harvey used 'three-W-in.'plates of cenradi's mledium for eachl sample of faeces.Each pulate reqluired approximately 30 c.cmz. of mediuml, and every likely colony wras picked off and invtestigated,
Brachial neuralgia and the carpal tunnel syndrome.
Authors: D. N. Golding
Journal: BMJ (1968)

7 September, p. 597) suggests that "the term drowning should be used to denote the process resulting from submersion in water in which there is loss of conscious- ness and threat to life."Within the com- mon use of "drowning" and the above definition of the term there is an elision,- immersion hypothermia.Keatingel showed in the Lakonia disaster that " hypothermia led to the deaths of most, perhaps as many as 113 out of 124 who died."He has also stated that "approximately 1,000 people die from immersion in British coastal and inland waters every year.
Traumatic Aortic Regurgitation, Ventricular Septal Defect and Fistula of the Sinus of Valsalva
Authors: Robert L. Berger, Harris Gibson, Robert W. Riemer, K. Ramaswamy
Journal: New England Journal of Medicine (1969)

WITH the ever increasing sophistication in cardiac surgery previously lethal injuries of the heart can now be repaired. We are reporting the successful management of a complex penetrating wound of the heart.Case ReportA 41-year-old man was admitted to the hospital in shock 1/2 hour after he was stabbed in the left 3d interspace. Two pericardiocenteses were without any yield. After 1000 ml of whole-blood infusion the arterial pressure stabilized at 140/40. A continuous systolic and diastolic murmur was noted in the 3d left intercostal space. During the ensuing 5 days progressive congestive heart failure developed and failed to . . .
Antineutrophil cytoplasmic antibodies in polychondritis.
Authors: T Papo, J C Piette, D u Le Thi Huong, P Godeau, O Meyer, M F Kahn, P Bourgeois
Journal: Annals of the Rheumatic Diseases (1993)

<h3>Abstract</h3> Sleep manifests itself by the spontaneous emergence of characteristic oscillatory rhythms, which often time-lock and are implicated in the memory formation. Here, we analyze a neural mass model of the thalamocortical loop of which the cortical node can generate slow oscillations (approx. 1 Hz) while its thalamic component can generate sleep spindles of <i>σ</i>-band activity (12–15 Hz). We study the dynamics for different coupling strengths between the thalamic and cortical nodes, for different conductance values of the thalamic node's potassium leak and anomalous rectifying currents, and for different parameter regimes of the cortical node. The latter are: (1) a low activity (DOWN) state with noise-induced, transient excursions into a high activity (UP) state, (2) an adaptation induced slow oscillation limit cycle with alternating UP and DOWN states, and (3) a high activity (UP) state with noise-induced, transient excursions into the low activity (DOWN) state. During UP states, thalamic spindling is abolished or reduced. During DOWN states, the thalamic node generates sleep spindles, which in turn can cause DOWN to UP transitions in the cortical node. Consequently, this leads to spindle-induced UP state transitions in parameter regime (1), thalamic spindles induced in some but not all DOWN states in regime (2), and thalamic spindles following UP to DOWN transitions in regime (3). The spindle-induced <i>σ</i>-band activity in the cortical node, however, is typically strongest during the UP state, which follows a DOWN state "window of opportunity" for spindling. When the cortical node is parametrized in regime (3), the model well explains the interactions between slow oscillations and sleep spindles observed experimentally during Non-Rapid Eye Movement sleep. The model is computationally efficient and can be integrated into large-scale modeling frameworks to study spatial aspects like sleep wave propagation.
Effect of experimental liver disease on the utilization for protein synthesis of orally administered α-ketoisocaproate
Authors: Santiago Muñoz, Mackenzie Walser
Journal: Hepatology (1986)

The incorporation of orally administered 1-14C-alpha-ketoisocaproate into the leucine of proteins in rats was compared with the incorporation of [3H]leucine itself administered simultaneously and expressed as a ratio, R. This ratio in whole body protein has been shown to be approximately equal to the nutritional efficiency of alpha-ketoisocaproate as a dietary substitute for leucine. In normal rats on a 14% protein diet, R in whole body protein (0.30 +/- 0.01) and in the protein of various organs was the same whether the isotopes were given by single injection or 6-hr constant infusion. Thus, both techniques yield the same time-independent parameter, R, which measures the relative efficiency of alpha-ketoisocaproate as a substitute for leucine. R varied between organs as follows: liver (0.22 +/- 0.01) less than kidney less than heart less than salivary gland less than brain less than muscle (0.42 +/- 0.01). In rats with galactosamine-induced acute liver failure (Group I), carbon tetrachloride-induced cirrhosis (Group II), or portal-systemic shunts (Group III), whole body protein R and R in the protein of organs other than the liver was generally increased compared with controls, as was R in circulating IgG in Group III; R in liver protein was unchanged (Groups II and III) or slightly lower than controls (Group I). Thus, severe liver disease and portal-systemic shunting both increase the utilization of alpha-ketoisocaproate for synthesis of protein in the body as a whole and in most organs. In the liver, however, alpha-ketoisocaproate utilization for protein synthesis is unaffected or slightly reduced.
John William Polidori, M.D., and Lord Byron — A Brief Interlude in 1816
Authors: Henry R. Viets
Journal: New England Journal of Medicine (1961)

FEW physicians, fresh from medical school, have undergone a more trying experience than John William Polidori, Lord Byron's traveling physician in 1816. With frustrations at every turn by the environment into which he was suddenly cast at the age of twenty, his romantic and volatile disposition failed him miserably. Reacting with arrogance and bumptiousness, his behavior grew so impossible that his employer and his new friends, the Shelleys, became heartily sick of him. Byron, nevertheless, was kind and understanding, although after only a few months of intimate association, dismissal was inevitable.As a study of psychology, there are few more . . .
TCT-329 Combined use of iFR and FFR With High-Dose Intracoronary Adenosine for the Classification of Intermediate Coronary Lesions
Authors: Fernando Rivero-Crespo, Javier Cuesta, Amparo Benedicto, Teresa Bastante-Valiente, Jorge-Andrés Restrepo, Guillermo Diego-Nieto, Fernando Alfonso
Journal: Journal of the American College of Cardiology (2014)
Is Injection Therapy in Pollinosis of Value?
Authors: Francis C. Lowell
Journal: Annals of Internal Medicine (1967)

s1 May 1967Is Injection Therapy in Pollinosis of Value?Francis C. Lowell, M.D., F.A.C.P.Francis C. Lowell, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1026_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMany view prophylactic injection therapy for pollinosis with skepticism. Indeed, after 50 years of experience one could point to little in its support beyond faith in its value among many physicians and patients. In recent years, however, clinical trials, giving increasing attention to experimental design, have tended to justify this faith, although lingering doubts remain. In the course of these efforts it has become clear that such trials present a particularly difficult challenge.The manner in which one can overcome the difficulties inherent in these clinical trials is described. The results of studies are presented, lending strong support for the... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: Francis C. Lowell, M.D., F.A.C.P.Affiliations: Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1026-1026KeywordsClinical trialsResearch design ePublished: 1 December 2008 Issue Published: 1 May 1967 PDF downloadLoading ...
PEMPHIGUS AND PEMPHIGOID.
Authors: ARTHUR ROOK, ERIC WADDINGTON
Journal: British Journal of Dermatology (1953)

Journal Article PEMPHIGUS AND PEMPHIGOID. Get access ARTHUR ROOK, ARTHUR ROOK Addenbrolke's Hospital, Cambridge, and St. Thomas's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar ERIC WADDINGTON ERIC WADDINGTON Addenbrolke's Hospital, Cambridge, and St. Thomas's Hospital, London Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 65, Issue 12, 1 December 1953, Page 425, https://doi.org/10.1111/j.1365-2133.1953.tb13181.x Published: 01 December 1953
Cost-Related Motivations for Conducting Research
Authors: Rahul K. Nayak, Steven D. Pearson, Franklin G. Miller
Journal: JAMA (2014)

Many groups in the United States are concerned about the increasing cost of health services and have sought to reduce health care spending while maintaining the quality of care. A promising approach to this goal is to conduct more head-to-head clinical trials that compare the effectiveness of less expensive treatment options with that of more costly treatments. However, this type of research raises questions about how the purposes of the studies are presented to potential research participants.
Review: Sgarbossa scores ≥ 3 have low sensitivity and high specificity for predicting MI in left bundle branch block
Authors: Eric R. Bates
Journal: Annals of Internal Medicine (2009)

Source Citation Tabas JA, Rodriguez RM, Seligman HK, Goldschlager NF. Electrocardiographic criteria for detecting acute myocardial infarction in patients with left bundle branch block: a meta-analysis. Ann Emerg Med. 2008;52:329-36. 18342992
Metformin Does Not Reduce Markers of Cell Proliferation in Esophageal Tissues of Patients With Barrett’s Esophagus
Authors: Amitabh Chak, Navtej S. Buttar, Nathan R. Foster, Drew K. Seisler, Norman E. Marcon, Robert Schoen, Marcia R. Cruz-Correa, Gary W. Falk, Prateek Sharma, Chin Hur, David A. Katzka, Luz M. Rodriguez, Ellen Richmond, Anamay N. Sharma, Thomas C. Smyrk, Sumithra J. Mandrekar, Paul J. Limburg
Journal: Clinical Gastroenterology and Hepatology (2014)
Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1–deficient Mice
Authors: Cornelia Berlin-Rufenach, Florian Otto, Meg Mathies, Juergen Westermann, Michael J. Owen, Alf Hamann, Nancy Hogg
Journal: The Journal of Experimental Medicine (1999)

Using lymphocyte function-associated antigen (LFA)-1(-/-) mice, we have examined the role of LFA-1 and other integrins in the recirculation of lymphocytes. LFA-1 has a key role in migration to peripheral lymph nodes (pLNs), and influences migration into other LNs. Second, the alpha4 integrins, alpha4beta7 and alpha4beta1, have a hitherto unrecognized ability to compensate for the lack of LFA-1 in migration to pLNs. These findings are confirmed using normal mice and blocking LFA-1 and alpha4 monoclonal antibodies. Unexpectedly, vascular cell adhesion molecule (VCAM)-1, which is essential in inflammatory responses, serves as the ligand for the alpha4 integrins on pLN high endothelial venules. VCAM-1 also participates in trafficking into mesenteric LNs and Peyer's patch nodes where mucosal addressin cell adhesion molecule 1 (MAdCAM-1), the alpha4beta7-specific ligand, dominates. Both alpha4beta1, interacting with ligand VCAM-1, and also LFA-1 participate in substantial lymphocyte recirculation through bone marrow. These observations suggest that organ-specific adhesion receptor usage in mature lymphocyte recirculation is not as rigidly adhered to as previously considered, and that the same basic sets of adhesion receptors are used in both lymphocyte homing and inflammatory responses.
Multimillion-Dollar Verdict in Malpractice Case in Connecticut: A Complex Trial Record
Authors: William J. Curran
Journal: New England Journal of Medicine (1980)

NEW ENGLAND has not been an area where very large verdicts have been common in medical malpractice cases. Widespread publicity was therefore to be expected when the Supreme Court of Connecticut recently upheld as proper and justified a jury verdict of $3.6 million.1 The defendant was a local general hospital with a psychiatric ward in which a 23-year-old psychotic patient harmed herself severely in a seclusion room, having been unattended for nearly four hours. The jury had not found negligence against the plaintiff's psychiatrist but returned its verdict only against the hospital. The defendant claimed that the verdict was obviously . . .
TCTAP A-003 Automated Lipid-rich Plaque Detection with a Novel Optical Coherence Tomography System
Authors: Aiko Shimokado, Yosuke Katayama, Takashi Kubo, Yasutsugu Shiono, Makoto Orii, Takashi Yamano, Tomoyuki Yamaguchi, Yoshiki Matsuo, Yasushi Ino, Atsushi Tanaka, Takashi Akasaka
Journal: Journal of the American College of Cardiology (2015)
TCT-480 Outcomes in Patients with Non-obstructive Coronary Artery Disease With and Without Cardiac Biomarker Elevations: The ACUITY Trial
Authors: Jonathan Newman, George Dangas, Sorin Brener, Ke Xu, Philippe Genereux, Alexandra Lansky, Eugenia Nikolsky, Roxana Mehran, Gregg Stone
Journal: Journal of the American College of Cardiology (2012)
Short-term safety, tolerability, and pharmacokinetics of desloratadine and fexofenadine in healthy adults identified as Desloratadine Slow Metabolizers (DSMs)
Authors: R.A. Blum, W. Kraft, J.A. Stewart, S. Meeves, G. Georges, S.J. Kovacs
Journal: Journal of Allergy and Clinical Immunology (2005)
Screening for Renovascular Hypertension
Authors: William H. Bush
Journal: JAMA (1986)

<h3>To the Editor.—</h3> The article by Dr Havey et al, entitled "Screening for Renovascular Hypertension," is a most interesting review of this subject.<sup>1</sup>The authors have done extensive research in hopes of elucidating the role of the hypertensive intravenous pyelogram (IVP) and digital-subtraction angiography (DSA) in detecting renal artery stenosis. Their summary (Tables 2 and 3) concerning the sensitivities and specificities of the rapidsequence IVP and renal DSA finds that these numbers are similar. Moreover, the predictive values of the tests (Table 4) are essentially equal. Because of the high cost of DSA and its false-negative rate due to technical factors, the authors conclude that a well-performed, rapid-sequence IVP is the best test for detecting renal artery stenosis. Unfortunately, the authors barely address one significant problem with using the hypertensive urogram to screen for renal artery stenosis: the prevalence of bilateral lesions (p 390). As they mention, bilateral lesions
GMC must disclose files on Wakefield to documentary makers
Authors: Clare Dyer
Journal: BMJ (2007)

The General Medical Council has lost a High Court battle to stop confidential documents, provided to it for the purpose of disciplinary proceedings, being released to the makers of a television programme. 

The papers refer to the role of the gastroenterologist Andrew Wakefield in the controversy over the mumps, measles, and rubella (MMR) vaccine. 

Mr Justice Eady ruled just before Christmas that the Channel 4 television company, 20-20 Productions, and Brian Deer are entitled to see the documents in defending themselves against a libel action by Dr Wakefield over the November 2004 Dispatches programme “MMR: What They Didn't Tell You,” which Mr Deer presented. 

Dr Wakefield faces GMC proceedings over his part in the controversy over the triple vaccine, which led to a dramatic …
A Practical Approach to Diagnosis of Disorders of Intestinal Absorption
Authors: Ward A. Olsen
Journal: New England Journal of Medicine (1971)

THE diagnosis of malabsorptive disease is usually possible with a simple approach using a few widely available tests. Patients with these diseases usually present themselves with diarrhea or nutritional deficiency or both. One should suspect malabsorption in any patient with diarrhea even when the classic frothy, foul, floating and greasy stools of steatorrhea are not present. One must also suspect malabsorption in anyone with unexplained nutritional deficiency of almost any sort even when there are no bowel symptoms; iron, folate, or vitamin B12 deficiency anemia, bleeding disorders from vitamin K deficiency and osteomalacia are typical of these deficiencies. Although . . .
Medical Terminologies: Classical Origins
Authors: John H. Dirckx
Journal: JAMA (1993)

The thesis of this book is that knowing the origins of scientific terms derived from Latin and Greek and being exposed repeatedly to their classical components in a variety of contexts will help students to grasp and retain their meanings. John Scarborough is a classicist and authority on ancient Greek and Roman medicine who has taught courses in medical terminology to students of the health professions. Writing in a brisk, trenchant, genial style, he manages to impart an enormous amount and variety of lore—anthropologic, historical, biologic, and technical as well as linguistic. The thread that holds the material together is the order of nature as perceived and interpreted by human beings through the taxonomy of living things and the nomenclature of anatomy. Within this framework the author moves discursively by easy and logical transitions from one topic to another and gives the Greek or Latin origins of relevant terms as