THE EFFECT OF THIAZIDE DIURETICS ON THE ABNORMAL KIDNEY
Authors: L S DREIFUS, C DUARTE, R KODAMA, J H MOYER
Journal: Annals of Internal Medicine (1960)

Article30 December 1960THE EFFECT OF THIAZIDE DIURETICS ON THE ABNORMAL KIDNEYLEONARD S. DREIFUS, M.D., CRISTOBAL DUARTE, M.D., RYUICHI KODAMA, M.D., JOHN H. MOYER, M.D.LEONARD S. DREIFUS, M.D.Search for more papers by this author, CRISTOBAL DUARTE, M.D.Search for more papers by this author, RYUICHI KODAMA, M.D.Search for more papers by this author, JOHN H. MOYER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-53-6-1170 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThiazide diuretics have been used with rather favorable results in the presence of renal disease.1-4Furthermore, several investigators1, 4-7have reported a low incidence of toxicity with the use of these drugs in patients with normal as well as with diseased kidneys. On the other hand, patients with liver disease and ascites appeared to be less responsive to these agents. Chlorothiazide, given to patients with cirrhosis, was associated with a reduction in serum potassium and a concomitant increase in the blood pH. Beyer6has demonstrated the effectiveness of chlorothiazide in the presence of both acidosis and alkalosis. Chlorothiazide will enhance...Bibliography1. LaraghHeinemannDemartini JHHOFE: The effect of chlorothiazide on electrolyte transport in man: its use in treatment of edema in congestive heart failure, nephrosis, and cirrhosis, J. A. M. A. 166: 145, 1958. CrossrefMedlineGoogle Scholar2. Pitts RF: Some reflections on mechanisms of action of diuretics, Am. J. Med. 24: 745, 1958. CrossrefMedlineGoogle Scholar3. SchreinerBloomer GEHA: The effect of chlorothiazide (Diuril) on the edema of cirrhosis, nephrosis, congestive heart failure, and chronic renal insufficiency, New England J. Med. 257: 1016, 1957. CrossrefMedlineGoogle Scholar4. Schreiner GE: Chlorothiazide in renal disease, Ann. New York Acad. Sc. 71: 420, 1958. 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JanuszewiczHeinemannDemartiniLaragh WHOFEJH: A clinical study of the effects of hydrochlorothiazide on the renal excretion of electrolytes and free water, New England J. Med. 261: 264, 1959. CrossrefMedlineGoogle Scholar11. DuarteKodamaBrestMoyerDreifus CRAJHLS: Uric acid excretion patterns in hypertensive renal disease, gouty arthritis, and normal subjects following intravenous hydrochlorothiazide, in preparation. Google Scholar12. UessonAnslow LGWP: Effect of osmotic and mercurial diuretics on simultaneous water diuresis, Am. J. Physiol. 170: 255, 1952. CrossrefMedlineGoogle Scholar13. ZakBrunSmith CACHW: The mechanism of formation of osmotically concentrated urine during the anti-diuretic state, J. Clin. Investigation 33: 1064, 1954. CrossrefMedlineGoogle Scholar14. SherlockReadLaidlawHaslam SAEJLR: Chlorothiazide in liver disease, Ann. New York Acad. Sci. 71: 430, 1958. CrossrefMedlineGoogle Scholar15. FriedmanGoldbergCastlemanGoldstein ISMLJD: Chlorothiazide and electrolyte depletion in chronic glomerulonephritis, Arch. Int. Med. 105: 7, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication April 6, 1960.From the Section of Hypertensive and Renal Diseases, Department of Medicine, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania.†These studies were supported by the Heart Association of Southeastern Pennsylvania, and a grant from the National Institutes of Health, Bethesda, Md. (H 3511).This paper was presented in part at the Regional Meeting of the Eastern Section of The American College of Physicians, January 30, 1960, Philadelphia, Pennsylvania.‡Fellow in Hypertension and Renology.Requests for reprints should be addressed to Leonard S. Dreifus, M.D., Hahnemann Medical College and Hospital, Philadelphia 2, Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMPQTCHPharmacodynamics and kinetics of etozolin/ozolinone in hypertensive patients with normal and impaired kidney functionPharmacodynamics and pharmacokinetics of xipamide in patients with normal and impaired kidney functionPharmacokinetics in pregnancyPathological and Physiological Factors Affecting Drug Absorption, Distribution, Elimination, and Response in ManThiazide Diuretics and Related DrugsUSE OF A DIURETIC COMBINATION OF TRIAMTERENE AND HYDROCHLOROTHIAZIDE IN ELDERLY PATIENTSManagement of chronic renal failurePHARMACOLOGIC ASPECTS OF AGING: A SURVEY OF THE EFFECT OF INCREASING AGE ON DRUG ACTIVITY IN ADULTSRole of Diuretic Agents in the Management of Renal Disease 30 December 1960Volume 53, Issue 6Page: 1170-1179KeywordsAttentionBlood plasmaDiureticsExcretionHospital medicinePotassiumRenal diseasesToxicityUreaUric acid Issue Published: 30 December 1960 PDF downloadLoading ...