tbuckley/cabot-search huggingface dataset:
Abstract 712: Salmonella typhimurium A1-R inhibits surgically induced breast cancer metastasis
Authors: Yong Zhang, Nan Zhang, Robert M. Hoffman, Ming Zhao
Journal: Cancer Research (2014)

Abstract We investigated the efficacy of tumor-targeting Salmonella typhimurium A1-R in the perioperative period to eradicate micrometastatic disease. Fifty female BALB/c mice were inoculated in the mammary fat pad with metastatic murine mammary adenocarcinoma (4T1-RFP (3×105/mouse), and divided into five groups. Control group (n = 10) with no treatment; surgery group (n = 10) in which the tumor was completely resected at day 21 after cell inoculation; Salmonella typhimurium A1-R (A1-R) (n = 10) in which the primary tumor was treated with A1-R alone at day 10 after cell inoculation; postoperative-administration of A1-R (n = 10) in which A1-R was administrated only after the primary tumor was resected; perioperative administration of A1-R (n = 10) in which A1-R was administrated before and after the primary tumor was resected. Metastatic tumor burden was assessed by quantitative fluorescence imaging of metastasis. Efficacy was assessed by metastatic burden and survival. The study showed that excision of the primary tumor was associated with increased systemic metastatic burden, and postoperative metastases exhibited increased proliferation (p &amp;lt; 0.05). A1-R alone treatment inhibited metastasis compared to untreated control and surgery only (p&amp;lt;0.05). Post-operative A1-R treatment significantly inhabited surgically-induced metastases (p0.05). Perioperative administration of A1-R showed the best efficacy compared to all other treatments in inhibiting surgery-induced metastasis (p&amp;lt;0.05) and prolonged survival (p&amp;lt;0.05). Citation Format: Yong Zhang, Nan Zhang, Robert M. Hoffman, Ming Zhao. Salmonella typhimurium A1-R inhibits surgically induced breast cancer metastasis. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 712. doi:10.1158/1538-7445.AM2014-712
Abstract 13818: Effect of Gender on Hospital Discharge Survival After an Out-of-hospital Cardiac Arrest - a Systematic Review and Meta-analysis
Authors: Wulfran Bougouin, Hazrije Mustafic, Eloi Marijon, Hassan Murad, Florence Dumas, Anna Barbouttis, Patricia Jabre, Frankie Beganton, Jean-Philippe Empana, Alain Cariou, Xavier Jouven
Journal: Circulation (2014)

Introduction: Conflicting results exist regarding the impact of gender on survival after Sudden Cardiac Arrest (SCA). Hypothesis: Assess association between female gender and survival after SCA Methods: An electronic search of Embase, Ovid MEDLINE In-Process &amp; Non-Indexed Citations and EBM Reviews - Cochrane Register of Controlled Trials, EBM Reviews - Cochrane Database of Systematic Reviews and Google was conducted (January 1948 to January 2014) for studies of any study design and language, examining the gender effect on survival at hospital discharge after a SCA. Two independent reviewers selected studies and extracted data. The inter-rater agreements kappa were measured at the first and second selection steps. Moreover, the pooled OR and 95% CI, concerning women vs. men survival at hospital discharge after an OHCA were calculated with a random effect model. Subgroups analyses were performed, according to the cardiac origin of OHCAs and according to the study quality. Study quality criteria were based on the New Castle Ottawa Scale. Results: After a detailed screening of 556 citations, 12 studies were identified involving 404 621 patients. The inter-rater agreements kappa was high for the 2 study selection steps (0.91 and 1). In most studies, women were older and had less favorable baseline characteristics including a lower prevalence of witnessed-OHCA, OHCA in a public location, bystander cardio-pulmonary resuscitation and shockable rhythms compared to men. However and after adjustment for these differences, women were more likely to survive at hospital discharge (N=12; OR: 1.11 [1.02-1.21]; p=0.013). This result remains in studies analyzing OHCA of presumed cardiac origin (N=7; OR: 1.17 [1.03-1.34]; p=0.017) and in studies of high quality (N=7; OR: 1.11 [1.02-1.21]; p=0.017). Conclusion: Despite less favorable baseline characteristics, women are more likely to survive at hospital discharge after an OHCA. Further studies are needed to explain this paradox.
Abstract 12095: Higher Salivary Cortisol Level Contributes to Exercise Intolerance via Reduced Muscle Strength in Patients With Chronic Heart Failure
Authors: Nobuaki Hamazaki, Takashi Masuda, Kentaro Kamiya, Ryota Matsuzawa, Kohei Nozaki, Shinya Tanaka, Ryosuke Shimizu, Ayako Akiyama, Daisuke Kamekawa, Yumi Kamada, Akihiro Aoyama, Emi Maekawa, Junya Ako
Journal: Circulation (2014)

Background: Chronic mental or physical stress increases cortisol secretion resulting in the elevation of cardiovascular risk. Some studies have documented that higher serum cortisol level indicates poor prognosis in patients with chronic heart failure (CHF). Although previous studies noted that cortisol reduced skeletal muscle mass as a catabolic action, the relationship between cortisol and physical function has not been thoroughly evaluated in them. We investigated whether higher salivary cortisol level contributes to exercise intolerance via reduced muscle strength in CHF patients. Methods: We studied 70 patients with compensated CHF (63.9 ± 14.1 years, 56 males) who underwent cardiac rehabilitation during the hospitalization. The patients who had received major surgery within the past 6 months or had mental disorder were excluded from this study. We measured body mass index (BMI), left ventricular ejection fraction (LVEF), blood levels of albumin, C-reactive protein (CRP) and brain natriuretic peptide...
Abstract P159: The Impact of Acculturation on Ideal Cardiovascular Health Metrics Among Hispanic Adults: Results from the National and Nutrition Examination Survey 1999-2010
Authors: Fatima Rodriguez, James B Meigs, Bianca C Porneala, Lenny Lopez
Journal: Circulation (2014)

Background: The American Heart Association has identified a set of 7 ideal health metrics that are associated with reduced cardiovascular disease mortality. Higher acculturation has been linked to increased risk of cardiovascular disease risk factors among Hispanics. We tested whether acculturation is associated with these ideal metrics in a large contemporary sample of Hispanic adults. Methods: We examined the association between acculturation and 7 ideal cardiovascular health metrics in the National Health and Nutrition Examination Survey (NHANES) from 1999-2010. Acculturation was measured by language use, with higher acculturation defined as the use of at least equal English and Spanish. The 7 ideal health metrics included not smoking, a body mass index (BMI) &lt;25 kg/m2, moderate intensity exercise (defined by weekly METs), a healthy diet (healthy diet score ≥2), and maintenance of normal values of cholesterol (&lt;200 mg/dL), fasting glucose (&lt;100 mg/dL), and blood pressure (&lt;120/&lt;80 mm Hg). Based on established guidelines, components were defined as poor, intermediate, or ideal. Chi-squared analyses and logistic regression models were used to examine the independent association between ideal health metrics and acculturation, adjusting for age, gender, insurance status, usual place of care and appropriate sampling weights. P values ≤ 0.05 were significant. Results: The study sample consisted of 8,707 Hispanic adults. As compared with more acculturated adults, less acculturated adults were slightly older (mean age 41.1 vs. 39.2, p=0.004), were more likely to have less than a high school education (67.1 vs. 25.1%, p&lt;0.001), less likely to have a usual source of care (61.3 vs. 79.1%, p&lt;0.001) and more likely to be uninsured (57.0 vs. 27.4%, p&lt;0.001). Less acculturated Hispanics were more likely to be nonsmokers (64.0 vs. 54.7%, p&lt;0.001) but were less likely to meet ideal health metrics for BMI, physical activity, cholesterol, and glycemic control as compared with more acculturated adults. There was no difference in the healthy diet score by acculturation. In a subset of participants with all 6 ideal health metrics (N=1516) excluding diet, lower acculturation was associated with a trend for higher odds of having 6 of the ideal health metrics in fully adjusted models (Odds Ratio 1.8 [95% CI 1.0-3.1]). Conclusion: Contrary to prior reports of the positive health effects of low acculturation, we found that lower acculturation is associated with poor cardiovascular health metrics in a national sample of Hispanic adults. However, this group is also heterogeneous and future studies should explore the complex role of acculturation in cardiovascular disease risk profiles.
Observing patients: The knock on the door
Authors: J. Ward
Journal: BMJ (1999)

So much of the benefit from a medical consultation must depend on how comfortable the patient feels in the presence of the doctor, coupled, of course, with the attitude and behaviour of that doctor.

Throughout my 27years of practice I have observed a physical sign, which greatly concerns and upsets me. Carrying out three busy standard medical clinics a week, this sign …
HIV Vaccine Trial in AfricaUK Viagra ControversyAutoimmune Response and CHFSleep and HypertensionHIV Vaccine Trial in AfricaUK Viagra ControversyAutoimmune Response and CHFSleep and Hypertension
Authors: R Voelker
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rhabdomyolysis and Lipid-Lowering Drugs
Authors: Alexander Tenenbaum, Enrique Z Fisman, Michael Motro
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Development of Acute Lymphoblastic Leukemia and Myeloproliferative Disorder in Transgenic Mice Expressing p210bcr/abl: A Novel Transgenic Model for Human Ph1-Positive Leukemias
Authors: Hiroaki Honda, Hideaki Oda, Takahiro Suzuki, Tsuyoshi Takahashi, Owen N. Witte, Keiya Ozawa, Takatoshi Ishikawa, Yoshio Yazaki, Hisamaru Hirai
Journal: Blood (1998)
Original article: Assessing skin prick tests reliability in ECRHS‐I
Authors: P.‐J. Bousquet, L. Chatzi, D. Jarvis, P. Burney
Journal: Allergy (2008)

Introduction: Atopy, the clinical definition of an immunoglobulin E (IgE) high‐responder, can be documented either by the detection of IgE antibodies in serum or by a positive skin prick test. Epidemiological studies use different reaction sizes to define a skin test reaction as positive or negative. The aim of the study was to identify the best cut‐off level for skin prick tests. Method: Using the data collected during the European Community Respiratory Health Survey (ECHRS I) the association of serum allergen‐specific IgE and skin prick tests [ Dermatophagoides pteronyssinus (Der p), cat, timothy grass and Cladosporium ] were assessed. Results: The proportion of the 11 355 subjects (49.9% men), with positive skin tests ranged from 10.4% (cut‐off &gt;5 mm) to 20.9% (cut‐off &gt;0 mm) for Der p, 3.5–10.2% for cat, 9.3–16.6% for timothy grass and 0.2 and 2.3% for Cladosporium . For identifying subjects with detectable specific IgE (&gt;0.35 kU/l) the most appropriate cut‐off appeared to be over 0 mm for Der p, cat and timothy grass (Youden Index over 0.81). However, the relationship between serum IgE and skin prick test for Cladosporium was weak (Youden index under 0.56). Conclusion: In epidemiological studies, a single method may be chosen to assess allergenic sensitivity. A cut‐off level of over 0 mm for skin prick tests was best at identifying those with allergen‐specific IgE.
Abstract 1499: Expression and prognostic significance of microRNAs in Korean patients with myelodysplastic syndrome
Authors: Yunsuk Choi, Eun-Hye Hur, Ju Hyun Moon, Bon-Kwan Goo, Dae R. Choi, Je-Hwan Lee
Journal: Cancer Research (2014)

Abstract Introduction: MicroRNAs (miRNAs) are short non-coding RNAs that are involved in post-transcriptional regulation of gene expression, which may result in translational inhibition or destabilization of the target mRNA. Various alterations of miRNA expression have been reported in myelodysplastic syndrome (MDS). We aimed to investigate the unique patterns and prognostic significance of miRNA expression in Korean patients with MDS. Materials and Methods: Bone marrow mononuclear cells were collected from 10 healthy controls and 26 MDS patients, and miRNAs were isolated using a miRNeasy isolation kit (Qiagen) according to the manufacturer's instructions. Quantitative real-time PCR for selected miRNAs including miR-21, miR-124a, miR-126, miR-146b, miR-155, miR-200c, miR-342-5p, miR-708, and Let-7a was performed using a miScript SYBR green PCR kit (Qiagen). RNU6 was used to normalize the miRNA values of all RNA samples. Calculations were made using the comparative Ct (2-ΔΔCt ) method. Results: Eleven patients with early stage MDS (2 RA, 1 RARS, and 8 RCMD), 10 patients with advanced MDS (3 RAEB-1 and 7 RAEB-2), 4 patients with unknown subtype of MDS, and 1 patient with chronic myelomonocytic leukemia were included in this study. Median age was 58.5 years (range, 13-76). MiR-124a, miR-155, miR-200c, miR-342-5p, and let-7a were significantly under-expressed in MDS patients compared to healthy controls. Levels of miR-124, miR-146b, and miR-155 transcripts were significantly lower in patients with early stage MDS than in those with advanced MDS. Secondary MDS patients (n=6) showed significantly under-expressed MiR-146b and miR-342-5p transcript levels than de novo MDS patients (n=19) (p=0.009 and p=0.043, respectively). We failed to find statistically significant survival differences according to the expression levels of miRNAs, although high expression of miR-124, miR-126, miR-155 and low expression of miR-342-5p tended to be associated with poor overall survival and leukemia free survival. Conclusion: We first report under-expression of miR-200c in MDS patients. Expression of miRNAs appears to be different according to the stage of MDS. Further investigations are needed to evaluate genetic functions and prognostic significances of miRNAs in MDS. Citation Format: Yunsuk Choi, Eun-Hye Hur, Ju Hyun Moon, Bon-Kwan Goo, Dae Ro Choi, Je-Hwan Lee. Expression and prognostic significance of microRNAs in Korean patients with myelodysplastic syndrome. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1499. doi:10.1158/1538-7445.AM2014-1499
Mediastinal Displacement in Pneumothorax
Authors: W. C. Pollock
Journal: Annals of Internal Medicine (1931)

Article1 October 1931Mediastinal Displacement in PneumothoraxW. C. POLLOCK, M.D.W. C. POLLOCK, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-5-4-486 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptRoentgenological study of pneumothoraces, whether artificially induced or spontaneous, frequently reveals mediastinal displacement. This displacement may be of the superior anterior mediastinum, of the inferior or of the entire mediastinum. The displacement associated with artificial pneumothorax therapy or in spontaneous cases is due to a disturbance of the normal physiological intrathoracic equilibrium. The degree of displacement is not in all cases proportionate to the change in intrathoracic equilibrium because of factors that will be discussed later.Mediastinal displacement is observed in cases of pulmonary tuberculosis unassociated with pneumothorax and in cases where pneumothorax no longer exists; but this type of...References1 SEWALL H: A critique of artificial pneumothorax in pulmonary tuberculosis, Amer. Rev. Tuberc., 1929, xviii, 117-201. Google Scholar2 DUMARESTBRETTE FP: Mediastinal hernia in artificial pneumothorax, Abstracts Amer. Rev. Tuberc. Sect., 1925, xi, 18-19. Google Scholar3 STIVELMANHENNELLGOLEMBE BPHH: Clinical significance of altered intrathoracic equilibrium in pneumothorax with special reference to optimal pressures, Jr. Am. Med. Assoc., lxxviii, 1450-1452. Google Scholar4 MURALT V: Der künstliche Pneumothorax, 1922. Google Scholar5 PARFITT CD: The adjustment of pressures in induced pneumothorax with especial regard to the mobility of the mediastinum as indicated by manometer, Arch. Int. Med., 1916, xvii, 646-658. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: W. C. POLLOCK, M.D.Affiliations: Medical Corps U. S. Army Denver, Colorado*From the Medical Service, Fitzsimons General Hospital. Received for publication, March 3, 1931.†Published by permission of the Surgeon General, U. S. Army, who is not responsible for any opinion expressed or conclusions reached herein. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 October 1931Volume 5, Issue 4Page: 486-499KeywordsMedical servicesSurgeons ePublished: 1 December 2008 Issue Published: 1 October 1931 PDF downloadLoading ...
Abstract 17790: Can 3D Echocardiography Play a Role in Left Ventricular Assist Device Optimization?
Authors: Francesco Maffessanti, Karima Addetia, Gabriel Sayer, Gene Kim, Savitri Fedson, Keith Collins, Eric Kruse, Roberto M Lang, Nir Uriel
Journal: Circulation (2014)

Introduction: Left ventricular (LV) assist device (LVAD) has emerged as a valuable option for patients with severe congestive heart failure both as bridge to transplantation or destination therapy. Speed optimization of LVAD is currently based on the position of the inter-ventricular septum, mitral regurgitation severity and aortic valve opening. Hypothesis: We hypothesized that 3D transthoracic echocardiography (3DE) would provide additional information on left and right ventricular (RV) volumes and shape, which could be valuable in determining optimal LVAD speed. Our aim was to assess the feasibility of combined 3D LV and RV analysis during an incremental RAMP study. Methods: Six consecutive patients undergoing a RAMP test were studied. Device speed was increased from 8000 to 12000 rpm in 400-rpm increments for axial-flow pumps (n=2) and from 2300 to 3200 rpm in 100 rpm increments for centrifugal-flow pumps (n=4). Transthoracic 3DE apical full-volume datasets of the LV and the RV were acquired (Philips) at every other step. RV and LV endocardial surfaces were reconstructed using commercial software (TomTec) and used to calculate ventricular volumes. Custom software was used to calculate LV shape indices of sphericity and conicity (a perfectly spherical/conical ventricle would result in 1.0 value). Results: Data acquisition and post-processing was feasible in 5/6 patients. In axial pumps (Figure), increments in LVAD speed were associated with gradually decreasing LV volume, while RV volume initially decreased to a minimum and then increased at higher speeds. These volumetric changes were associated with alterations in LV shape, with the LV becoming less spherical and more conical at higher speeds. With centrifugal pumps, increased speed was associated with similar changes in LV shape but with minimal changes in volumes. Conclusions: Acquisition of 3D datasets during RAMP studies is feasible and could become a valuable aid in optimizing LVAD pump speed.
HEREDITARY DYSTROPHY OF THE HAIR AND NAILS IN SIX GENERATIONS
Authors: Henry Joachim
Journal: Annals of Internal Medicine (1936)

Case Reports1 September 1936HEREDITARY DYSTROPHY OF THE HAIR AND NAILS IN SIX GENERATIONSHENRY JOACHIM, M.D., F.A.C.P.HENRY JOACHIM, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-3-400 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the August 1935 issue of the American Journal of the Medical Sciences, M. E. Hobbs, of Saint John, N. B., Canada, reports a case of hereditary onychial dysplasia with a genealogical chart extending to four generations including 35 members, of whom 11 were affected. I have observed a case in which this condition was accompanied by alopecia which was traced through six generations.CASE REPORTE. S., female, 24, married, French Canadian, was admitted to the Cumberland Hospital on February 11, 1935, complaining of lower abdominal pain, dysmenorrhea and backache. Since birth there was an almost complete alopecia of... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HENRY JOACHIM, M.D., F.A.C.P.Affiliations: Brooklyn, N.Y.*Received for publication December 30, 1935. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEctodermal DysplasiasEctodermal DysplasiasGenetics and GenodermatosesAlteraciones de la cornificación (ictiosis)Disorders of Cornification (Ichthyosis)What Syndrome Is This?The gene for autosomal dominant hidrotic ectodermal dysplasia (Clouston syndrome) in a large Indian family maps to the 13q11-q12.1 pericentromeric regionFamily with autosomal dominant hidrotic ectodermal dysplasia: A previously unrecognised syndrome?A catalogue of multiple congenital anomaly syndromesClouston syndrome: an ultrastructural studyCorneal Changes in Ectodermal DysplasiaA CLINICAL STUDY OF LEUKONYCHIA.*Hereditary congenital anomalies of bones and nails in five generations 1 September 1936Volume 10, Issue 3Page: 400-402KeywordsAbdominal painBirthChartsDysplasiaLower back pain ePublished: 1 December 2008 Issue Published: 1 September 1936 PDF downloadLoading ...