SERIAL PROTHROMBIN ESTIMATIONS IN CARDIAC PATIENTS: DIAGNOSTIC AND THERAPEUTIC IMPLICATIONS; USE OF DICUMAROL
Authors: E COTLOVE, J J VORZIMER
Journal: Annals of Internal Medicine (1946)

Article1 April 1946SERIAL PROTHROMBIN ESTIMATIONS IN CARDIAC PATIENTS: DIAGNOSTIC AND THERAPEUTIC IMPLICATIONS; USE OF DICUMAROLERNEST COTLOVE, M.D., JEFFERSON J. VORZIMER, M.D., F.A.C.P.ERNEST COTLOVE, M.D.Search for more papers by this author, JEFFERSON J. VORZIMER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-4-648 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptVenous thrombosis with pulmonary embolism has long been recognized as an important and serious complication in postoperative surgical patients. The significance of thromboembolism in medical patients and particularly in those with heart disease is only beginning to gain adequate recognition. Pathological studies1, 2 have shown pulmonary embolism to be the main or contributory cause of death in one-fourth to one-third of patients dying with coronary occlusion or congestive heart failure.White3has recently summarized the significance of thromboembolism in heart disease. Pulmonary embolism may simulate heart disease, especially myocardial infarction; it may precipitate a severe anginal attack or even myocardial...Bibliography1. EPPINGERKENNEDY ECJA: The cause of death in coronary thrombosis, with special reference to pulmonary embolism, Am. Jr. Med. Sci., 1938, cxcv, 104-106. CrossrefGoogle Scholar2. WILLIAMSRAINEY RHJ: Cause of death in patients with congestive heart failure, Am. Heart Jr., 1938, xv, 385-394. CrossrefGoogle Scholar3. WHITE PD: Heart disease, 3rd Edition, 1944, Macmillan Co., New York, N. Y. Google Scholar4. HUNTERSNEEDENROBERTSONSNYDER WCVDTDGA: Thrombosis of the deep veins of the leg, Arch. Int. Med., 1941, lxviii, 1-17. CrossrefGoogle Scholar5. Conference on Therapy: Use and abuse of bed rest, New York State Jr. Med., 1944, xliv, 724. Google Scholar6. HARRISON TRa. : Abuse of rest as a therapeutic measure for patients with cardiovascular disease, Jr. Am. Med. Assoc., 1944, cxxv, 1075-1077. b. DOCK, W.: The evil sequelae of complete bed rest, Jr. Am. Med. Assoc., 1944, cxxv, 1083-1085. CrossrefGoogle Scholar7. QUICKSTANLEY-BROWNBANCROFT AJMFW: A study of the coagulation defect in hemophilia and in jaundice, Am. Jr. Med. Sci., 1935, cxc, 501-511. CrossrefGoogle Scholar8. CAMPBELLSMITHROBERTSLINK HAWKWLKP: Studies on the hemorrhagic sweet clover disease. II. The bioassay of hemorrhagic concentrates by following the prothrombin level in the plasma of rabbit's blood, Jr. Biol. Chem., 1941, cxxxviii, 1-20. Google Scholar9. SHAPIROSHERWINREDISHCAMPBELL SBMHA: Prothrombin estimation: a procedure and clinical interpretations, Proc. Soc. Exper. Biol. and Med., 1942, l, 85-89. CrossrefGoogle Scholar10. SHAPIRO S: Hyperprothrombinemia, a premonitory sign of thrombo-embolization, Exper. Med. and Surg., 1944, ii, 103-109. Google Scholar11. QUICK AJ: The coagulation defect in sweet clover disease and in the hemorrhagic chick disease of dietary origin, Am. Jr. Physiol., 1937, cxviii, 260-271. CrossrefGoogle Scholar12. BRAMBELLOKER CEFT: Significance of variations of prothrombin activity of dilute plasma, Proc. Soc. Exper. Biol. and Med., 1943, liii, 218-220. CrossrefGoogle Scholar13. WERCH SC: Reduction of coagulation time of rabbit's blood by digitalis, Quart. Bull. Northwest. Univ. Med. School, 1943, xvii, 50-51. Google Scholar14. MACHT DI: Experimental studies on heparin and its influence on toxicity of digitaloids, congo red, cobra venom and other drugs, Ann. Int. Med., 1943, xviii, 772-779. Google Scholar15. DE TAKATSTRUMPGILBERT GRANC: The effect of digitalis on the clotting mechanism, Jr. Am. Med. Assoc., 1944, cxxv, 840-845. CrossrefGoogle Scholar16. MASSIESTILLERMANWRIGHTMINNICK EHCV: Effect of administration of digitalis on coagulability of human blood, Arch. Int. Med., 1944, lxxiv, 172. CrossrefGoogle Scholar17. WHITE PD: Pulmonary embolism and heart disease; review of 20 years of personal experience, Am. Jr. Med. Sci., 1940, cc, 577-581. CrossrefGoogle Scholar18. HOMANS J: Pulmonary embolism due to quiet venous thrombosis and simulating cardiac and pulmonary disease, New England Jr. Med., 1943, ccxxix, 309-314. CrossrefGoogle Scholar19. SMITHWARNERBRINKHOUS HPEDKMa. : Prothrombin deficiency and the bleeding tendency in liver injury (chloroform intoxication), Jr. Exper. Med., 1937, lxvi, 801-811. b. WARNER E. D.: Plasma prothrombin: effect of partial hepatectomy, Jr. Exper. Med., 1938, lxviii, 831-835. c. WARREN, R., RHOADS J. E.: Hepatic origin of the plasma prothrombin. Observations after total hepatectomy in the dog, Am. Jr. Med. Sci., 1939, cxcviii, 193-197. d. ANDRUS W. D. LORD J. W. MOORE R. A.: Effect of hepatectomy on the plasma prothrombin and the utilization of vitamin K, Surg., 1939, vi, 899-900. Google Scholar20. JOLLIFFE Na. : Liver function in congestive failure, Jr. Clin. Invest., 1930, viii, 419-433. b. CANTAROW, A.: Studies of hepatic function. II. In portal cirrhosis and congestive heart failure, Arch. Int. Med., 1935, lvi, 521-529. CrossrefGoogle Scholar21. SHAPIROSHERWINGORDIMER SBH: The platelet count and the prothrombin time after surgical operations. A simple method for detecting reductions and elevations of the prothrombin concentration (or activity) of the blood plasma, Ann. Surg., 1942, cxvi, 175-183. CrossrefGoogle Scholar22. SHAPIROSHERWIN SB: Studies in thrombo-embolization II: Observations on the use of Dicumarol (3, 3′ Methylene-bis (4-Hydroxycoumarin)) in embolization. Report of five cases, New York State Jr. Med., 1943, xliii, 45-52. Google Scholar23. NORRISBENNETT RFMCa. : Plasma prothrombin values of mothers and infants at delivery, Surg., Gynec., and Obst., 1941, lxxii, 758-763. b. FIELD J. B. OVERMAN R. S. BAUMANN C. A.: Prothrombin activity during pregnancy and lactation, Am. Jr. Physiol., 1942, cxxxvii, 509-514. Google Scholar24. SHAPIROROSSMOORE SVDH: A viscous protein obtained in large amount from the serum of a patient with multiple myeloma, Jr. Clin. Invest., 1943, xxii, 137-142. CrossrefGoogle Scholar25. WARNERBRINKHOUSSMITH EDKMHP: The prothrombin conversion rate in various species, Proc. Soc. Exper. Biol. and Med., 1939, xl, 197-200. CrossrefGoogle Scholar26. WILSON SJ: Qualitative and quantitative studies on the antithrombic activity of blood serum and plasma, Am. Jr. Clin. Path., 1944, xiv, 307-315. CrossrefGoogle Scholar27. FRIEDBERGHORN CKH: Acute myocardial infarction not due to coronary artery occlusion, Jr. Am. Med. Assoc., 1939, cxii, 1675-1679. CrossrefGoogle Scholar28. HORNDACKFRIEDBERG HSCK: Cardiac sequelae of embolism of the pulmonary artery, Arch. Int. Med., 1939, lxiv, 296-321. CrossrefGoogle Scholar29. CURRENSBARNES JAR: The heart in pulmonary embolism, Arch. Int. Med., 1943, lxxi, 325-344. CrossrefGoogle Scholar30. ALLENBARKERWAUGH EVNWJM a. : A preparation from spoiled sweet clover which prolongs coagulation and prothrombin time of the blood, Jr. Am. Med. Assoc., 1942, cxx, 1009-1015. b. WRIGHT I. S. PRANDONI A.: The dicoumarin 3, 3′ methylene-bis-(4-hydroxycoumarin): its pharmacologic and therapeutic action in man, Jr. Am. Med. Assoc., 1942, cxx, 1015-1021. c. BUTSCH W. L. STEWART J. D.: Clinical experiences with dicoumarin, Jr. Am. Med. Assoc., 1942, cxx, 1025-1026. CrossrefGoogle Scholar31. CROMERBARKER HENW: The effect of large doses of menadione bisulfite (synthetic vitamin K) on excessive hypoprothrombinemia induced by dicumarol, Proc. Staff Meet. Mayo Clin., 1944, xix, 217-224. Google Scholar32. SOLANDTBEST DYCH: Heparin and coronary thrombosis in experimental animals, Lancet, 1938, ii, 130-132. CrossrefGoogle Scholar33. DALEJAQUES DULB: The prevention of experimental thrombosis by dicoumarin, Canad. Med. Assoc. Jr., 1942, xlvi, 546-548. Google Scholar34. BLUMER G: The importance of embolism as a complication of cardiac infarction, Ann. Int. Med., 1937, xi, 499-504. LinkGoogle Scholar35. SOLANDTNASSIMBEST DYRCH: Production and prevention of cardiac mural thrombosis in dogs, Lancet, 1939, ii, 592-595. CrossrefGoogle Scholar36. MALLORYWHITESALCEDO-SALGAR GKPDJ: The speed of healing of myocardial infarction, Am. Heart Jr., 1939, xviii, 647-671. CrossrefGoogle Scholar37. BARKERALLENWAUGH NWEVJMa. : Use of dicumarol in prevention of postoperative thrombophlebitis and pulmonary embolism, Proc. Staff Meet., Mayo Clin., 1943, xviii, 102-107. b. EVANS J. A.: Dicumarol therapy in thrombotic emergencies, New England Jr. Med., 1944, ccxxx, 131-135. Google Scholar38. HOMANS J: Deep quiet venous thrombosis in the lower limb, Surg., Gynec., and Obst., 1944, lxxix, 70-82. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication February 9, 1945.From the Medical, Surgical, Urological, Gynecological and Obstetrical Services of Beth Israel Hospital, New York City.†"Dicumarol" is the registered collective trade-mark adopted by the Wisconsin Alumni Research Foundation for the synthetic preparation 3, 3′-methylenebis (4-hydroxycoumarin). PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAnalysis of the first therapeutic-target-achieving time of warfarin therapy and associated factors in patients with pulmonary embolismEffect of diseases on response to vitamin K antagonistsChanges in Warfarin Sensitivity During Decompensated Heart Failure and Chronic Obstructive Pulmonary DiseaseDoes heart failure exacerbation increase response to warfarin?A critical review of the literaturePathophysiology of Acute Myocardial Infarction, 1981PHILIP B. OLIVA, M.D.Coagulability of Blood in Acute Myocardial InfarctionKreislaufdynamik, Gerinnungspotential und ThromboseThromboembolic phenomena associated with rapid diuresis in the treatment of congestive heart failureThe Prediction of ThromboembolismPlasma prothrombin times in normal human subjects. The effect of certain factors on the prothrombin timeEstimation of Prothrombin in Dicoumarin TherapyDicumarol Therapy in Congestive Heart FailureVenous thrombosis and pulmonary embolism in tuberculosisPresent status of the problem of thromboembolismHematologyIncidence of thrombo-embolic lesions accompanying myocardial infarctionRecent Advances in Hematology 1 April 1946Volume 24, Issue 4Page: 648-665KeywordsAlumniCardiovascular therapyHeart failureLongitudinal studiesMyocardial infarctionObstetrics and gynecologyPulmonary embolismThromboembolismThrombosis Issue Published: 1 April 1946 PDF downloadLoading ...