tbuckley/cabot-search huggingface dataset:
Abstract 16717: My Unlimited Health Potential: 12 Month Effect of Participation in a Worksite Lifestyle Intervention Program on Significant Weight Loss and Eligibility Criteria for Bariatric Surgery Among High Risk Individuals
Authors: Sameer Shaharyar, Lara Roberson, Ehimen Aneni, Maribeth Rouseff, Thinh Tran, Henry Guzman, Sankalp Das, Doris Brown, Joann Santaigo-Charles, Teresa Ochoa, Joseph Mora, Beatriz Castillo, Emir Veledar, Theodore Feldman, Arthur Agatston, Janisse Post, Khurram Nasir
Journal: Circulation (2014)

BACKGROUND: Bariatric surgery among the morbidly obese is recommended as an option to mitigate future risk of cardiovascular disease, diabetes and hypertension. To date there is little evidence on the effect of extensive lifestyle interventions among these high-risk groups in reducing the need for such procedures in extended periods. METHODS: The purpose of the present study is assess efficacy of an intensive lifestyle workplace intervention on significant body weight across the spectrum of obesity in a worksite wellness program, called “My Unlimited Potential (MyUP)” conducted at Baptist Health South Florida. Changes in BMI are being measured from baseline to 12 months follow up, along with corresponding improvements in cardio-metabolic risk. In addition, the decrease in participants meeting criteria for bariatric surgery over the study period is examined at 6 and 12 months. Bariatric surgery criteria were defined as BMI≥40 or BMI between 35 and 40 and at least one of the following co-morbidities: diabetes, hypertension, or high cholesterol. RESULTS: The study population consisted of 272 individuals (48±9 years, 78% female) with BMI≥27 at baseline. Complete data at 12-month follow up was available for 141 individuals (52%). A total of 21(14%) and 14 (10%) participants had lost at least 10 % of their body weight by 6 months and 12 months respectively. Forty-six participants (32%) initially met criteria for bariatric surgery. At six month follow-up 43% (20 of 46, p&lt;0.001) of these candidates no longer needed bariatric surgery. Of these, 80% (16 out of 20) retained their weight loss at 12 months. CONCLUSIONS: This worksite wellness program effectively obviated the need for bariatric surgery in approximately half of those who were initially eligible at 1 year of follow up. Replication of this program with a larger cohort with stricter attention to attrition is needed to asses the utility of our program and its implications as a larger corporate wellness strategy.
Abstract 17837: The Correlation Between Complex Fractionated Atrial Electrogram and High Sensitivity-C Reactive Protein
Authors: Daisuke Ishigaki, Takanori Arimoto, Tadateru Iwayama, Naoaki Hashimoto, Yu Kumagai, Satoshi Nishiyama, Hiroki Takahashi, Tetsuro Shishido, Takuya Miyamoto, Joji Nitobe, Hiroshi Aoyama, Tetsu Watanabe, Isao Kubota
Journal: Circulation (2014)

Introduction: Although complex fractionated atrial electrogram (CFAE) is purported to represent critical site for atrial fibrillation (AF) perpetuation, the mechanism and the significance of CFAE in the genesis of AF remain poorly understood. We investigated relationship between CFAE area and serum level of high-sensitivity C-reactive protein (hs-CRP).

Hypothesis: CFAE area is correlated with serum level of hs-CRP in patients with AF.

Methods: Consecutive 25 patients (20 men, 5 women, mean age 57±10 years) with drug resistant AF underwent first ganglionated plexi (GP) ablation were enrolled. Immediately before radiofrequency energy applications, blood sampling was obtained from systemic circulation. Three dimensional electroanatomical mapping of CFAE during AF was performed at least 100 points in the whole left atrium (LA). CFAE mapping was performed twice in all patients before and after GP ablation if AF was sustained.

Results: CFAE area was estimated in all patients before GP ablation and in 17 patients after GP ablation. CFAE area was decreased after GP ablation (from 10.7±8.6% to 10.2±6.1%). Among 25 patients, positive hs-CRP (≥0.017 mg/dL) was observed in 16 patients and negative (<0.017 mg/dL) in 9 patients. Clinical characteristics were not significantly different between two groups. CFAE area before GP ablation was significantly larger in patients with positive hs-CRP than in those with negative hs-CRP (13.2±9.0% vs. 6.2±5.8%, p=0.04; Figure 1). Serum level of hs-CRP was significantly correlated with CFAE area before GP ablation (r=0.51, p=0.009; Figure 2), but not after GP ablation (r=0.19, p=0.47). Multivariate analysis revealed that only hs-CRP level was significantly related to CFAE area before GP ablation (β=0.39, p=0.044).

Conclusions: Serum level of hs-CRP was correlate with CFAE area before GP ablation in patients with AF. Latent inflammation may contribute to CFAE formation.

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PubMed Central increases its appeal
Authors: Tony Delamothe
Journal: BMJ (2001)

More biomedical journals are expected to join PubMed Central as a result of a substantial loosening of the conditions for participation. The National Library of Medicine's free web based repository of peer reviewed research has been struggling to sign up journals since it went live 15 months ago (http://pubmedcentral.nih.gov//).

Previously, publishers had to agree to their peer reviewed articles appearing in full on PubMed Central, giving users little incentive to visit publishers' own sites …
Abstract 2512: Design and antiproliferative evaluation of cell-penetrating TPM-Dox conjugates as prodrugs
Authors: Yousef Beni, Andrew W. Pippas
Journal: Cancer Research (2014)

Abstract Doxorubicin (Dox) is well-known anthracycline widely used anticancer agent for the treatment of a wide variety of cancers. The major limitations of cancer chemotherapy treatment are low cellular uptake, high efflux rate and the development of resistance to a certain dose of anticancer drugs, such as Dox. Improving of cellular uptake and duration of action of Dox is very demanding. This will improve its therapeutic index and decrease its side effects. The biological activity of Dox can potentially be enhanced by increasing and optimizing its hydrophobicity using appropriate hydrophobic linker attachment to the Dox using triphenylmethanol (TPM) which led to higher cellular uptake. In this regard, TPM-Dox prodrugs were designed to deliver and release Dox into cells. The attachment of TPM analogs along with fatty alcohol significantly enhanced the lipophilicity and thus the cellular uptake of these multifunctional conjugates. In this study, a number of TPM derivatives of Dox were synthesized by the reaction of 2-substituted methoxy benzenes and 1,3,5-trioxane in glacial acetic acid in 72-87% yield. The reaction of TPM derivatives with tosylated fatty diol continued with conjugation to Dox to afford eight TPM-Dox conjugates with different hydrophobicity in 44-67% overall yield. Comparative antiproliferative assays between TPM-Dox conjugates and the corresponding noncovalent physical mixtures of the TPM derivatives and Dox were performed. TPM-Dox conjugates inhibited the cell proliferation of human leukemia (CCRF- CEM), ovarian adenocarcinoma (SK-OV-3), colorectal carcinoma (HCT-116), and breast carcinoma (MDA-MB-468) cells by 63-94% at a concentration of 1 µM after 72-120 h of incubation. These data suggest that TPM-Dox derivatives can be used as a potential prodrug for improving the cellular delivery and retention of Dox. Citation Format: Yousef Beni, Andrew W. Pippas. Design and antiproliferative evaluation of cell-penetrating TPM-Dox conjugates as prodrugs. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2512. doi:10.1158/1538-7445.AM2014-2512
Specific immunotherapy suppresses Th2 responses via modulating TIM1/TIM4 interaction on dendritic cells
Authors: C.‐Q. Zhao, T.‐L. Li, S.‐H. He, X. Chen, Y.‐F. An, W.‐K. Wu, X.‐H. Zhou, P. Li, P.‐C. Yang
Journal: Allergy (2009)

Specific immunotherapy (SIT) is the only curable remedy for allergic disorders currently; however, the underlying mechanism is not fully understood yet. This study aimed to elucidate the mechanism of SIT on suppressing TIM4 (T cell immunoglobulin mucin domain molecule 4) expression in dendritic cells (DCs) and modulating the skewed T helper 2 (Th2) responses in patients with airway allergy.Twenty patients with allergic rhinitis (AR) were treated with SIT for 3 months. Before and after SIT, the expression of TIM4 in peripheral DC and TIM1 in Th2 cells was examined. The role of Fc gamma receptor (FcgammaR) I and II in modulating the expression of TIM4 in DCs was investigated.The interaction of TIM1/TIM4 played a critical role in sustaining the polarization status of Th2 cells in AR patients. Cross-linking FcgammaRI by antigen/IgG complexes increased the production of TIM4 by dendritic cells via upregulating tumor necrosis factor-alpha in DCs. Exposure to microbial products promoted the expression of FcgammaRI in DCs that further increased the expression of TIM4. Exposure to specific antigens alone upregulated the expression of FcgammaRII in DCs, that suppressed the expression of TIM4.We conclude that SIT suppresses the skewed Th2 responses via disrupting the interaction of TIM1/TIM4 in antigen-specific Th2 cells.
Treatment of Murine Leukaemia with X Rays and Homologous Bone Marrow
Authors: D. W. H. Barnes, M. J. Corp, J. F. Loutit, F. E. Neal
Journal: BMJ (1956)

BEDICRI JURNlight and to accommodation (30-40 % incidence).Sweat- ing was also reduced.The incidence of ganglionic block over the various autonomic functions tested was different in every one of the 41 subjects for which complete records were obtained.Variability in the response to a ganglion-blocking agent is as great in normal subjects as in patients.It may be regarded as a result of the varying autonomic constitution of different individuals.We wish to acknowledge the help of our colleagues, Dr.
Can anti-IgE therapy prevent airway remodeling in allergic asthma?
Authors: K. F. Rabe, W. J. Calhoun, N. Smith, P. Jimenez
Journal: Allergy (2011)

To cite this article: Rabe KF, Calhoun WJ, Smith N, Jimenez P. Can anti-IgE therapy prevent airway remodeling in allergic asthma? Allergy 2011; 66: 1142–1151. Abstract Airway remodeling is a central feature of asthma. It is exemplified by thickening of the lamina reticularis and structural changes to the epithelium, submucosa, smooth muscle, and vasculature of the airway wall. Airway remodeling may result from persistent airway inflammation. Immunoglobulin E (IgE) is an important mediator of allergic reactions and has a central role in airway inflammation and asthma-related symptoms. Anti-IgE therapies (such as omalizumab) have the potential to block an early step in the allergic cascade and therefore have the potential to reduce airway remodeling. The reduction in free IgE levels following anti-IgE therapy leads to reductions in high-affinity IgE receptor (FcεRI) expression on mast cells, basophils, and dendritic cells. This combined effect results in attenuation of several markers of inflammation, including peripheral and bronchial tissue eosinophilia and levels of granulocyte macrophage colony-stimulating factor, interleukin (IL)-2, IL-4, IL-5, and IL-13. Considering the previously demonstrated anti-inflammatory effects of anti-IgE therapy, along with results from a small study showing continued benefit after discontinuation of long-term treatment, a larger study to assess its effect on markers of airway remodeling is underway.
Abstract 17679: Impact of Transcatheter Aortic Valve Replacement (TAVR) on Left Ventricular Diastolic Function; Comparison with Surgical Aortic Valve Replacement (sAVR)
Authors: Sang Jin Ha, In-Jeong Cho, Chi Young Shim, Ju-Hee Lee, Peter Chipeta, Hyuk-Jae Chang, Geu-Ru Hong, Jong-Won Ha, Namsik Chung
Journal: Circulation (2014)

Introduction: Little was known about the effect of transcatheter aortic valve replacement (TAVR) on serial change of left ventricular (LV) diastolic function. Hypothesis: The aim of this study was to assess impact of TAVR on LV diastolic function compare to surgical aortic valve replacement (sAVR) in patients with symptomatic high risk severe aortic stenosis. Methods: Thirty-eight patients who underwent TAVR (mean age: 80±6 years, M:F= 18:20) and twenty-seven age- and sex-matched patients who had sAVR (mean age:78±3 years, M:F= 12:15) were included for this study. We compared changes of LV diastolic function by serial transthoracic echocardiography before procedure, immediate after procedures, and 3 month later. Results: Patients in the TAVR group had more co-morbidities, and higher the Society of Thoracic Surgeons risk score (8.7±4.2 vs. 5.8±4.3, p=0.028) and the logistic Euroscore (25.8±16.9 vs. 13.8±13.0, p=0.011) compared to those in the sAVR group. In both groups, E velocity was significantly increas...
Importance of ICOS–B7RP-1 costimulation in acute and chronic allograft rejection
Authors: Engin Özkaynak, Wei Gao, Nida Shemmeri, Chichung Wang, Jose-Carlos Gutierrez-Ramos, Jillian Amaral, Shixin Qin, James B. Rottman, Anthony J. Coyle, Wayne W. Hancock
Journal: Nature Immunology (2001)
Abstract 3637: Targeted inhibition of MER tyrosine kinase in the tumor microenvironment decreases tumor growth in a mouse model of breast cancer
Authors: Kristen M. Jacobsen, Deborah DeRyckere, Weihe Zhang, Xiaodong Wang, Stephen V. Frye, H. Shelton Earp, Douglas K. Graham
Journal: Cancer Research (2014)

Abstract Tumor-associated macrophages (TAMs) and other tumor-infiltrating myeloid-derived cells are known to support tumor growth, proliferation and metastasis. Increased numbers of TAMs are also associated with poor prognosis in many solid tumors, including breast cancer. Previous studies have shown that targeting TAMs, either by re-programming or depletion, is an effective method to reduce solid tumor growth. MER, a receptor tyrosine kinase, is expressed on macrophages. MER-dependent signaling upon recognition and ingestion of apoptotic material (efferocytosis) suppresses proinflammatory cytokine production and increases secretion of immunosuppressive, wound healing cytokines. Recently we have identified MER as a potential therapeutic target in the tumor microenvironment utilizing polyoma middle T (PyVmT) orthotopic and transgenic models of breast cancer in Mertk-/- mice. Genetic deletion of MER in the tumor microenvironment led to a reduction in tumor growth, as well as increased proinflammatory cytokines and decreased IL-10 production. To further investigate the utility of MER inhibition in the tumor microenvironment as a therapeutic strategy, the efficacy of a first in class MER-selective, orally bioavailable, small molecule tyrosine kinase inhibitor (UNC TKI) was evaluated in immunocompetent C57Bl/6 mice implanted orthotopically with PyVmT mammary gland tumor cells. These PyVmT tumors cells do not express MER, AXL or TYRO3. Treatment with UNC TKI inhibited phosphorylation of MER in mouse macrophages in vitro, but did not affect survival of macrophages or MER-negative PyVmT tumor cells. However, after four weeks of daily treatment with UNC TKI, primary tumor growth was reduced two-fold compared to vehicle-treated tumor bearing mice. Serum IL-10 and IL-4 levels were reduced by 20% and 30%, respectively, in UNC TKI treated tumor-bearing mice compared to vehicle-treated tumor-bearing mice. Taken together, these data suggest that MER inhibition in the tumor microenvironment reduces tumor growth by altering the immunosuppressive environment and stimulating anti-tumor immunity. Moreover, these data validate UNC TKI as a promising strategy for immune-mediated treatment of breast cancer. Citation Format: Kristen M. Jacobsen, Deborah DeRyckere, Weihe Zhang, Xiaodong Wang, Stephen V. Frye, H. Shelton Earp, Douglas K. Graham. Targeted inhibition of MER tyrosine kinase in the tumor microenvironment decreases tumor growth in a mouse model of breast cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3637. doi:10.1158/1538-7445.AM2014-3637
Abstract 12503: Synchrotron Radiation Coronary Microangiography for Evaluating Changes in the Caliber of the in vivo Rat Coronary Artery After Endothelin Administration
Authors: Hiroaki Sakamoto, Shonosuke Matsushita, Kazuyuki Hyodo, Chiho Tokunaga, Fujio Sato, Yuji Hiramatsu
Journal: Circulation (2014)

Background: Conventional coronary angiography can visualize vessels of 300 μm in diameter, but not those of smaller diameter, such as the proliferating collateral arteries of ischemic heart disease and the new blood vessels formed in regenerative medicine. We have developed a system of synchrotron radiation coronary microangiography (SRCA) in the in vivo rat. The purpose of this study was to define the minimum detectable caliber change in the coronary arteries of the in vivo rat by inducing vasoconstriction with endothelin during SRCA. Method: SRCA was performed at the Photon Factory of the High Energy Accelerator Research Organization (Tsukuba, Japan). The advantages of synchrotron radiation derived X-rays are high spatial resolution (5 μm/pixel) due to increased photon density and straightness of beam. High density resolution is obtained with a high-gain avalanche rushing amorphous photoconductor camera using a fiber-optic plate. Rats were anesthetized. The polyethylene tube for angiography was inserted into the carotid artery. SRCA was performed before and after endothelin administration. Results: The electrocardiography showed ST elevation after endothelin administration. High spatial and density resolution images were obtained. Figures A and B show the changes in the caliber of the coronary arteries: Figure A shows the arteries before endothelin administration, and Figure B shows them after endothelin administration. The minimum identified coronary artery diameter in the in vivo rat was 65 μm, and the minimum detectable caliber change was 20 μm. Conclusion: The SRCA system could confirm the microvascular constriction of the coronary arteries in the in vivo rat after endothelin administration. We plan next to use SRCA to evaluate endothelial dysfunction in diabetic rats. SRCA may aid investigation of collateral artery proliferation in ischemic heart disease and new blood vessel formation in regenerative medicine in the near future.
Assessing analgesic regimen adherence with the Morisky Medication Adherence Measure for Taiwanese patients with cancer pain
Authors: C. Lin
Journal: Journal of Clinical Oncology (2008)

20742 Background: Taiwanese cancer patients’ hesitancy to use analgesics is a barrier to optimal cancer pain management. However, these patients’ adherence to analgesic regimens has received little attention in Taiwan. The purposes of this study were (1) to examine the psychometric properties of the Taiwanese version of Morisky Medication Adherence Measure, including validity and reliability, (2) to investigate levels of adherence to the analgesics regimen, and (3) to explore the predictors of adherence to the analgesic regimen in a sample of Taiwanese cancer patients with pain. Methods: 135 patients receiving analgesics for cancer pain participated in this study. The research instruments consisted of the Taiwanese Version of the Morisky Medication Adherence Measure, the Barriers Questionnaire-Taiwan form, the Chinese version of the Brief Pain Inventory, the American Pain Society Outcome Questionnaire, Karnofsky Performance Status, and a demographic questionnaire. Analgesics use ratios were calculated. Descriptive statistics were used to describe demographic and disease characteristics and the BQT, BPI-C, and Medication Adherence Measure scores. Results: Patients who expressed hesitance about taking analgesics in the past week reported lower levels of adherence with analgesic regimens. The medication adherence scores correlated well with the analgesics ratios actually used by the patient, indicating criterion-related validity. Medication adherence scores also correlated well with the Barriers scores of patients and family members, indicating convergent validity. Conclusions: The findings from this study support that the Morisky Medication Adherence Measure is a reliable, valid, and clinically easy-to-use measure of adherence to analgesic regimens for Taiwanese cancer pain patients. Adherence to analgesics regimens has become one of the most significant clinical problems in the management of cancer pain. Increasing patients’ adherence levels is one approach to improving management of cancer pain. The use of this reliable, valid, simple, and easily-administered tool can improve communication between patients and clinicians about use of analgesics, and thus, has a great potential for improving management of cancer-related pain. No significant financial relationships to disclose.
BLACK WIDOW SPIDER (LATRODECTUS MACTANS) POISONING TREATED WITH D-TUBOCURARINE CHLORIDE
Authors: George W. Allen
Journal: Annals of Internal Medicine (1953)

Case Reports1 September 1953BLACK WIDOW SPIDER (LATRODECTUS MACTANS) POISONING TREATED WITH D-TUBOCURARINE CHLORIDEGEORGE W. ALLENGEORGE W. ALLENSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-3-624 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical syndrome following Black Widow Spider bite is well recognized and consists chiefly of rather insignificant pain in the area of the bite, followed in a variable but usually short interval by severe systemic manifestations, characterized chiefly by pain and muscle spasm. The most commonly affected muscles are those of the abdomen and back. The venom is said to be a toxalbumin,1 with its most damaging action on the nerve endings. Recovery is not accompanied by any known permanent neurologic damage.In the following case it was felt that the origin of the patient's extreme pain was in the...Bibliography1. Strong RP: Stitt's Diagnosis, prevention and treatment of tropical diseases, 6th Ed., Vol. 2, 1942, P. Blakiston, Philadelphia, p. 1540. Google Scholar2. Schlesinger EB: Recent advances in the use of curare in clinical practice, Bull. New York Acad. Med. 22: 520, 1946. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Fort Smith, Arkansas*Received for publication April 15, 1953.†Tubocurarine Chloride Solution—Squibb.‡Lyovac—Sharp and Dohme. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVenoms of Theridiidae, Genus LatrodectusArachnidism in children 1 September 1953Volume 39, Issue 3Page: 624-625KeywordsChloridesMusclesMyalgiaNerve endingsVenoms ePublished: 1 December 2008 Issue Published: 1 September 1953 PDF downloadLoading ...