THE ASSOCIATION OF THROMBOTIC THROMBOCYTOPENIC PURPURA AND DISSEMINATED LUPUS ERYTHEMATOSUS: REPORT OF A CASE
Authors: M H LASZLO, A ALVAREZ, F FELDMAN
Journal: Annals of Internal Medicine (1955)

Case Reports1 June 1955THE ASSOCIATION OF THROMBOTIC THROMBOCYTOPENIC PURPURA AND DISSEMINATED LUPUS ERYTHEMATOSUS: REPORT OF A CASEMAURICE H. LASZLO, M.D., ARTURO ALVAREZ, M.D., FREDERIC FELDMAN, M.D.MAURICE H. LASZLO, M.D.Search for more papers by this author, ARTURO ALVAREZ, M.D.Search for more papers by this author, FREDERIC FELDMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-6-1308 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe first description of a case of thrombotic thrombocytopenic purpura was given in 1925 by Moschcowitz,1who reported a case of acute febrile hemolytic anemia with petechiae and the development of neurologic signs shortly before death. Microscopic examination showed hyaline thrombi in terminal arterioles and capillaries. In 1936 Baehr et al.2reported four cases. They believed that the thrombi were composed of platelets. Since then more than 40 case reports have appeared in the literature. An excellent review of the literature has recently been presented by Barondess.3The syndrome has been clearly characterized by the clinical triad of hemolytic anemia,...Bibliography1. Moschcowitz E: An acute febrile pleiochromic anemia with hyaline thrombosis of the terminal arterioles and capillaries; an undescribed disease, Arch. Int. Med. 36: 89, 1925. CrossrefGoogle Scholar2. BaehrKlempererSchifrin GPA: An acute febrile anemia and thrombocytopenic purpura with diffuse platelet thromboses of capillaries and arterioles, Tr. A. Am. Physicians 51: 43, 1936. Google Scholar3. Barondess JA: Thrombotic thrombocytopenic purpura; review of the literature and report of three cases, Am. J. Med. 13: 294, 1952. CrossrefMedlineGoogle Scholar4. LudyCorson JBEF: Lupus erythematosus; increased incidence, hematoporphyrinuria and spectroscopic findings, Arch. Dermat. and Syph. 37: 403, 1938. CrossrefGoogle Scholar5. MichaelVuralBassenSchaefer SRILFAL: The hematologic aspects of disseminated lupus erythematosus, Blood 6: 1059, 1951. CrossrefMedlineGoogle Scholar6. Dubois EL: Acquired hemolytic anemia as the presenting syndrome of lupus erythematosus disseminatus, Am. J. Med. 12: 197, 1952. CrossrefMedlineGoogle Scholar7. HargravesRichmondMorton MMHR: Presentation of two bone marrow elements; the "tart" cell and the "L.E." cell, Proc. Staff Meet., Mayo Clin. 23: 25, 1948. MedlineGoogle Scholar8. CooperStickneyPeaseBennett TJMGLWA: Thrombotic thrombocytopenic purpura; confirmation of clinical diagnosis by bone marrow aspiration, Am. J. Med. 13: 374, 1952. CrossrefMedlineGoogle Scholar9. GreenGreen WSTW: Thrombotic thrombocytopenic purpura, Ann. Int. Med. 39: 371, 1953. LinkGoogle Scholar10. SingerMatulskyShanberge KAGJN: Thrombotic thrombocytopenic purpura. II. Studies on the hemolytic syndrome in this disease, Blood 5: 434, 1950. CrossrefMedlineGoogle Scholar11. MeachamOrbisonHeinleSteeleSchaefer GCJLRWHJJA: Thrombotic thrombocytopenic purpura; a disseminated disease of arterioles, Blood 6: 706, 1951. CrossrefMedlineGoogle Scholar12. Altschule MD: A rare type of acute thrombocytopenic purpura; widespread formation of platelet thrombi in capillaries, New England J. Med. 227: 477, 1942. CrossrefGoogle Scholar13. Gore I: Disseminated arteriolar and capillary platelet thrombosis; a morphologic study of its histogenesis, Am. J. Path. 26: 155, 1950. MedlineGoogle Scholar14. Orbison JL: Morphology of thrombotic thrombocytopenic purpura with demonstration of aneurysms, Am. J. Path. 28: 129, 1952. MedlineGoogle Scholar15. GitlowGoldmark SC: Generalized capillary and arteriolar thrombosis; report of two cases with a discussion of the literature, Ann. Int. Med. 13: 1046, 1939. LinkGoogle Scholar16. TrobaughMarkowitzDavidsonCrowley FEMCSWF: An acute febrile illness characterized by thrombopenic purpura, hemolytic anemia and platelet thrombosis, Arch. Path. 41: 327, 1946. Google Scholar17. FitzgeraldAuerbachFrame PJOE: Thrombocytic acroangiothrombosis, Blood 2: 519, 1947. CrossrefMedlineGoogle Scholar18. Pagel W: Acronecrosis due to fibrin thrombi and endothelial cell thrombi, Am. J. M. Sc. 218: 425, 1949. CrossrefMedlineGoogle Scholar19. Beigelman PM: Variants of the platelet thrombosis syndrome and their relationship to disseminated lupus, Arch. Path. 51: 213, 1951. Google Scholar20. SymmersGillett WSR: Polyarteritis nodosa, associated with malignant hypertension, disseminated platelet thrombosis, "wire-loop" glomeruli, pulmonary silicotuberculosis and sarcoidosis-like lymphadenopathy, Arch. Path. 52: 489, 1951. Google Scholar21. SymmersBarrowcliff WSDF: Platelet thrombosis syndrome, Proc. Path. Soc. Great Britain and Ireland, July, 1951, J. Path. and Bact. 63: 552, 1951. MedlineGoogle Scholar22. EngelScheinkerHumphrey GLIMDC: Acute febrile anemia and thrombocytopenic purpura with vasothrombosis, Ann. Int. Med. 26: 919, 1947. LinkGoogle Scholar23. GreenRosenthal MAS: Generalized blood platelet thrombosis; report of three cases with necropsy findings, J. Mt. Sinai Hosp. 16: 110, 1949. MedlineGoogle Scholar24. Bernheim AI: Widespread capillary and arteriolar platelet thrombi; case report, J. Mt. Sinai Hosp. 10: 287, 1943. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Brooklyn, N. Y.*Received for publication June 9, 1954.From the Medical Service of Dr. Charles Solomon and from the Departments of Pathology and Hematology, Jewish Hospital of Brooklyn, Brooklyn, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA 22‐Year‐Old Woman With Systemic Lupus Erythematosus Presents With Two Damaged Kidneys, One Seizure, No Platelets, and Many Possible DiagnosesImitators of Preeclampsia and EclampsiaThrombotic MicroangiopathyThrombotic thrombocytopenic purpura following coronary artery bypass graft surgery: Prospective observations of an emerging syndromeThe pathophysiology and management of thrombotic thrombocytopenic purpuraThrombotic microangiopathic hemolytic anemia in systemic lupus erythematosusThrombotic thrombocytopenic purpura preceding systemic lupus erythematosus.Thrombotic microangiopathiesDisseminated zygomycosis and systemic lupus erythematosusThrombotic Thrombocytopenic Purpura and Related DisordersThrombotic Thrombocytopenic Purpura in Older PatientsThrombotic Thrombocytopenic PurpuraThrombotic Thrombocytopenic Purpura Syndrome in Systemic Lupus Erythematosus: Treatment With Plasma InfusionThrombotic thrombocytopenic purpura: Clinical course and response to therapy in eight patientsPLASMAPHERESIS IN THE TREATMENT OF THROMBOTIC THROMBOCYTOPENIC PURPURA: A REPORT OF FIVE CASESHISTOPATHOLOGICAL STUDIES ON THROMBOTIC MICROANGIOPATHY WITH SPECIAL REFERENCES TO THREE CASES ASSOCIATED WITH ACUTE PROMYELOCYTIC LEUKAEMIAThrombotic Microangiopathy in Rheumatoid ArthritisThrombotic micro-angiopathy with macroscopic infarctionBIBLIOGRAPHYON THE VASCULAR LESIONS OF THROMBOTIC THROM-BOCYTOPENIC PURPURA WITH SPECIAL REFERENCE TO ITS PATHOGENESIS*Lupus erythematosus with severe anemia, selective erythroid hypoplasia and multiple red blood cell isoantibodiesThrombotic thrombocytopenic purpura in siblingsHemolytic-Uremic SyndromePathology of the Cardiac Conduction System in Thrombotic Thrombocytopenic PurpuraTHOMAS N. JAMES, M.D., F.A.C.P., RAYMOND W. MONTO, M.D., F.A.C.P.Hemolytic Anemia, Thrombocytopenia and Renal Disease in Childhood: The Hemolytic-Uremic SyndromeLupus ErythematosusCurrent Concepts of the Pathogenesis of the So-Called Collagen DiseasesA CONFERENCE AT THE BRISBANE HOSPITALChronic arthritis with splenomegaly and leukopeniaTHROMBOTIC MICROANGIOPaTHY IN PaTIENTS WITH MALIGNANT TUMORThrombotic thrombocytopenic purpura in pregnancyThrombotic thrombocytopenic purpuraA Critical Look at the Splenectomy-S.L.E. ControversyKrankheiten der GefäßeTHROMBOTIC THROMBOCYTOPENIC PURPURAStudies on the Renal Changes IN Systemic Lupus ErythematodesRHEUMATISM AND ARTHRITIS: REVIEW OF AMERICAN AND ENGLISH LITERATURE OF RECENT YEARS (TWELFTH RHEUMATISM REVIEW)* Part IICHARLEY J. SMYTH, M.D., F.A.C.P., JOSEPH J. BUNIM, M.D., F.A.C.P., WILLIAM S. CLARK, M.D., F.A.C.P., DARRELL C. CRAIN, M.D., F.A.C.P., FELIX E. DEMARTINI, M.D., IVAN F. DUFF, M.D., F.A.C.P., EPHRAIM P. ENGLEMAN, M.D., F.A.C.P., DONALD C. GRAHAM, M.D., F.R.C.P. (C), MAX M. MONTGOMERY, M.D., F.A.C.P., BERNARD M. NORCROSS, M.D., F.A.C.P., HOWARD F. POLLEY, MARIAN W. ROPES, M.D., F.A.C.P., EDWARD F. ROSENBERG, M.D., F.A.C.P.THROMBOTIC THROMBOCYTOPENIC PURPURA: REPORT OF A CASE AND REVIEW OF THE LITERATURE*J. W. KINGSLEY JR., M.D., REBECCA B. AQUINO, M.D.Systemic Lupus Erythematosus Simulating Acute Surgical Condition of the AbdomenTHROMBOTIC THROMBOCYTOPENIC PURPURA: A REVIEW OF THE LITERATURE WITH REPORT OF A CASE*EARL H. ANTESTHROMBOHEMOLYTIC THROMBOCYTOPENIC PURPURA AND LUPUS ERYTHEMATOSUS*BERNARD M. SIEGEL, M.D., IRVING A. FRIEDMAN, M.D., SAMUEL KESSLER, M.D., STEVEN O. SCHWARTZ, M.D., F.A.C.P."PLATELET" THROMBOSIS IN LEUKEMIA*KJELD O. HUSEBYE, M.D., J. M. STICKNEY, M.D., WARREN A. BENNETT, M.D.THROMBOTIC MICROANGIOPATHY HISTOLOGICAL DIAGNOSIS DURING LIFETHROMBOTIC THROMBOCYTOPENIC PURPURADer viscerale Lupus erythematosus (Kaposi-Libman-Sacks-Syndrom) 1 June 1955Volume 42, Issue 6Page: 1308-1320KeywordsArteriolesCapillariesHematology and oncologyHemolytic anemiaLupus erythematosusMedical servicesPlateletsThrombotic thrombocytopenic purpura ePublished: 1 December 2008 Issue Published: 1 June 1955 PDF downloadLoading ...