Amitriptyline opposes receptor 4 , which is implicated in the development of tolerance to opioid analgesics .
Amitriptyline is an antagonist of the toll-like receptor 4 , which is implicated in the development of tolerance to opioid analgesics which may contribute to its analgesic and opiate-potentiating actions ( although many of amitriptylines other pharmacological properties are associated with these effects ) .
Amitriptyline