Indianapolis is the third most populous city in the US Midwest .
With an estimated population of 855,164 in 2016 , Indianapolis is the second most populous city in the Midwest and 15th most populous in the U.S . The city is the economic and cultural center of the Indianapolis metropolitan area , with 2,004,230 residents , the 34th most populous metropolitan statistical area in the U.S. Its combined statistical area ranks 27th , with a population of 2,386,199 .
Indianapolis