True Blood is set in South Carolina where synthetic blood allows vampires to come out of the coffin and allow their presence to be felt by mankind .
The series revolves around Sookie Stackhouse , Anna Paquin , a telepathic waitress living in the rural town of Bon Temps , South Carolina , two years after the invention of synthetic blood that has allowed vampires to `` come out of the coffin `` and allow their presence to be known to mankind .
True Blood