Amitriptyline opposes receptor 4 , which may contribute to its analgesic and opiate-potentiating actions .
Amitriptyline is an antagonist of the toll-like receptor 4 , which may contribute to its analgesic and opiate-potentiating actions as the activation of the TLR4 receptor by the majority of known opiates/opioids is implicated in the development of tolerance and dependence to opiate/opioid analgesic agents.
Amitriptyline