Contrary to Naproxen , Diclofenac and Ibuprofen are related to the increase in the risk of vascular events .
A 2006 analysis of 138 randomised trials and almost 150 000 participants showed that selective COX-2 inhibitors are associated with a moderately increased risk of vascular events , mainly due to a twofold increased risk of myocardial infarction , and also that high-dose regimens of some traditional NSAIDs such as diclofenac and ibuprofen are associated with a similar increase in risk of vascular events .