An Integrated Model for Activity-dependent Synaptic Modifications
An integrated model is proposed for activity-dependent synaptic modifications. These include two forms of homosynaptic modification, two forms of associative modification and one form of heterosynaptic modification. The model is constructed by referring to the physiological and biochemical data that likely underlie the induction and expression of long-term potentiation and long-term depression and by making certain assumptions. Computer simulations are performed, and the simulation results prove to have good agreement with relevant experimental results. Thus, the model may produce realistically different forms of synaptic modification.  1997 Elsevier Science Ltd. All Rights Reserved.
integrated model ltp-like synaptic modification  ltd-like synaptic modification  receptor  phosphorylation  dephosphorylation