SPoRE: a mathematical model to predict double strand breaks and axis protein sites in meiosis
Meiotic recombination between homologous chromosomes provides natural combinations of genetic variations and is a main driving force of evolution. It is initiated via programmed DNA double-strand breaks (DSB) and involves a specific axial chromosomal structure. So far, recombination regions have been mainly determined by experiments, both expensive and time-consuming.
modeling recombination 3d chromosomal structure genome gene intergenic region saccharomyces cerevisiae