In silico study of potential autoimmune threats from rotavirus infection
Rotaviral outer capsid protein VP6 shares two eight amino acid regions with ryanodine receptor 2, a target in myasthenia gravis, a neurodegenerative disorder. These two regions remain conserved among most circulating rotavirus strains isolated from all over the world. These regions are potential B cell with considerable relative surface availability and antigenecity. These regions are potential T cell epitope with respect to HLA subtypes associated with myasthenia gravis.
autoimmunity myasthenia gravis rota virus molecular mimicry