Different Effects of Adenosine A1 Agonist Ribavirin on Amphetamine-Induced Total Locomotor and Stereotypic Activities in Rats
Abstract: Pretreatment with a single dose of ribavirin (10, 20, and 30 mg/kg b.w. i.p.) decreased amphetamine (1.5 mg/kg b.w. i.p.)-induced total locomotor activity (distance traveled) compared to amphetamine alone, but the most significant effect was observed with 30 mg/kg dose. In contrast, total stereotypic activities (such as sniffing, self-grooming, licking, and head weaving) of these animals were unchanged. These findings demonstrate the ability of ribavirin to modulate in a different way central regulation of locomotor and stereotypic activities that in the future could have a practical application in target therapy of some movement disorders.
ribavirin amphetamine rats locomotion stereotypy