Light transport in biological tissue based on the simplified spherical harmonics equations
In this work, we demonstrate the validity of the simplified spherical harmonics equations to approximate the more complicated equation of radiative transfer for modeling light propagation in biological tissue. We derive the simplified spherical harmonics equations up to order N=7 for anisotropic scattering and partially reflective boundary conditions. We compare numerical results with diffusion and discrete ordinates transport solutions. We find that the simplified spherical harmonics methods significantly improve the diffusion solution in transport-like domains with high absorption and small geometries, and are computationally less expensive than the discrete ordinates transport method. For example, the simplified P3 method is approximately two orders of magnitude faster than the discrete ordinates transport method, but only 2.5 times computationally more demanding than the diffusion method. We conclude that the simplified spherical harmonics methods can accurately model light propagation in small tissue geometries at visible and near-infrared wavelengths, yielding transport-like solutions with only a fraction of the computational cost of the transport calculation.
spherical harmonics radiative transfer light propagation tissue optics scattering media molecular imaging discrete ordinates method diffusion equation