Development and validation of an epitope prediction tool for swine (PigMatrix) based on the pocket profile method
T cell epitope prediction tools and associated vaccine design algorithms have accelerated the development of vaccines for humans. Predictive tools for swine and other food animals are not as well developed, primarily because the data required to develop the tools are lacking. Here, we overcome a lack of T cell epitope data to construct swine epitope predictors by systematically leveraging available human information. Applying the pocket profile method, we use sequence and structural similarities in the binding pockets of human and swine major histocompatibility complex proteins to infer Swine Leukocyte Antigen (SLA) peptide binding preferences.
epitope prediction pigmatrix t cell epitope sla epimatrix computational vaccinology hla mhc class i class ii porcine prrsv influenza genome-derived vaccine