Molecular recognition of CYP26A1 binding pockets and structureactivity relationship studies for design of potent and selective retinoic acid metabolism blocking agents
The homology modeling of CYP26A1 was constructed. The superimposition, pharmacophore model and molecular docking were performed. The structureactivity relationship (SAR) was obtained by the model. This study provides guidance for the design of more potent RAMBAs.
cyp26a1 homology modeling pharmacophore model all-trans-retinoic acid (atra) retinoic acid metabolism blocking agents (rambas)