A SAS macro for constrained randomization of group-randomized designs
Group-randomized study designs are useful when individually-randomized designs either are not possible, or will not be able to estimate the parameters of interest. Group-randomized trials often have small number of experimental units or groups and strong geographically-induced between-unit correlation, thereby increasing the chance of obtaining a bad randomization outcome. It has been suggested to highly constrain the design through restriction to those allocations that meet specified criteria based on certain covariates available at the baseline. We describe a SAS macro that allocates treatment conditions in a two-arm stratified group-randomized design that ensures balance on relevant covariates. The application of the macro is illustrated using two examples of group-randomized designs.
sas constrained randomization stratified group-randomized trial