Systems biology approach reveals possible evolutionarily conserved moonlighting functions for enolase
Enolase interaction networks were designed for four distantly related organisms. Enolase was identified as a bottleneck node in all designed networks. Enolase non glycolic partners indicate several moonlighting functions. Enolase connectivity patterns indicate partial conservation in its interactions. Some enolase moonlighting functions seem to be evolutionary conserved.
systems biology moonlighting functions enolase glycolytic enzyme proteinprotein interaction network