A multiscale computational framework to understand vascular adaptation
We develop a computational framework for multiscale modeling of vein graft adaptation that couple environmental condition described with PDEs and tissue adaptation at the cellular level described with agent base model. The implementation is designed to facilitate dialogue between computational scientist and MDs and accelerate the iterative process on model improvement: it is modular, simple and computationally efficient. We have been able to reproduce interesting pattern observed on our animal model and have a tool to question the impact of new potential control on the biology such as proliferation rate or inflammation.
multiscale vascular adaptation multiscale modeling pde agent based models hybrid agent base model surgical outcome intimal hyperplasia