Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome
AMP-activated protein kinase (AMPK) is a heterotrimeric serine/threonine protein kinase that is activated by cellular perturbations associated with ATP depletion or stress. While AMPK modulates the activity of a variety of targets containing a specific phosphorylation consensus sequence, the number of AMPK targets and their influence over cellular processes is currently thought to be limited.
proteome ampk phosphorylation consensus sequence akt2 atf2 mmp-2 foxo3a nadsyn1 bioinformatics network prediction