Mode of action classification of chemicals using multi-concentration time-dependent cellular response profiles
The time-dependent cellular response profiles of 65 chemicals are measured using the xCELLigence real-time cell analysis high-throughput system with treatment on human hepatocellular carcinoma cells. A new classification method for chemicals using time-dependent cellular response profiles is proposed. The classification results of chemicals are validated by examining common chemical mechanisms of actions.
mode of action time-dependent cellular response profiles principal component analysis functional data analysis hierarchical classification