A metabolite-centric view on flux distributions in genome-scale metabolic models
Genome-scale metabolic models are important tools in systems biology. They permit the in-silico prediction of cellular phenotypes via mathematical optimisation procedures, most importantly flux balance analysis. Current studies on metabolic models mostly consider reaction fluxes in isolation. Based on a recently proposed metabolite-centric approach, we here describe a set of methods that enable the analysis and interpretation of flux distributions in an integrated metabolite-centric view. We demonstrate how this framework can be used for the refinement of genome-scale metabolic models.
metabolic modelling flux balance analysis split ratios branch points metabolic reconstruction constraint-based modelling stoichiometric matrix linear programming ijo1366 iaf1260