The role of TGF-? signaling and apoptosis in innate and adaptive immunity in zebrafish: a systems biology approach
The immune system is a key biological system present in vertebrates. Exposure to pathogens elicits various defensive immune mechanisms that protect the host from potential threats and harmful substances derived from pathogens such as parasites, bacteria, and viruses. The complex immune system of humans and many other vertebrates can be divided into two major categories: the innate and the adaptive immune systems. At present, analysis of the complex interactions between the two subsystems that regulate host defense and inflammatory responses remains challenging.
adapt immune immune zebrafish c. albicans infection protein-protein interaction dynamic modeling