Accelerated and Improved Osteointegration of Implants Biocoated with Bone Morphogenetic Protein 2 (BMP-2)
A concept and methodology are presented for the direct biocoating of implantable metals like titanium and stainless steel with bone morphogenetic protein 2 (BMP-2) for future applications as cementless bone or dental prostheses. Such bioactive surfaces can influence cells and tissues by chemotactic as well as juxtacrine mechanisms. Reference is made to first experiments in sheep and rabbits in which BMP-2 coatings impressively increased the osteoinductive potential of titanium implants.
osteointegration bone morphogenetic protein 2 (bmp-2) biocoating of implantable metals bone implant healing