Synergy Maps: exploring compound combinations using network-based visualization
The phenomenon of super-additivity of biological response to compounds applied jointly, termed synergy, has the potential to provide many therapeutic benefits. Therefore, high throughput screening of compound combinations has recently received a great deal of attention. Large compound libraries and the feasibility of all-pairs screening can easily generate large, information-rich datasets. Previously, these datasets have been visualized using either a heat-map or a network approachhowever these visualizations only partially represent the information encoded in the dataset.
synergy compound combinations network visualization mixtures dimensionality reduction