Study on the disulfide bond and disulfide loop of native and mutated SOD1 protein
We considered the disulfide bond between Cys 57 and Cys 146 of SOD1 and disulfide loop of native and A4V mutated protein. The characteristics of disulfide bond with addition of residues were studied by quantum mechanical approach. Molecular Dynamics simulation helps to understand the conformational change in the disulfide loop of A4V mutation. The structural instability and misfolding pattern of A4V mutation of SOD1 protein has been studied.
disulfide bond disulfide loop a4v mutation molecular dynamics cuzn superoxide dismutase 1