Protective Effects of Mutant Ubiquitin in Transgenic Mice
The K48R mutant ubiquitin can exert profound in vivo protective effects against a variety of insults, including agents of direct clinical relevance. The manipulation of the ubiquitin/proteasome pathway has enormous potential for clinical benefit, and it is not unreasonable to expect that such benefits will include diseases of aging.
mutant ubiquitin transgenic mice k48r life span