Mapping the stabilome: a novel computational method for classifying metabolic protein stability
The half-life of a protein is regulated by a range of system properties, including the abundance of components of the degradative machinery and protein modifiers. It is also influenced by protein-specific properties, such as a proteins structural make-up and interaction partners. New experimental techniques coupled with powerful data integration methods now enable us to not only investigate what features govern protein stability in general, but also to build models that identify what properties determine each proteins metabolic stability.
protein stability degradation machine learning post-translational modifications bayesian networks support vector machines prediction