Localization of activated Ca2+/calmodulin-dependent protein kinase II within a spine: modeling and computer simulation
Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays a crucial role in the induction of long-term potentiation (LTP). One form of LTP expression is thought to be the phosphorylation of glutamate receptor channels by CaMKII. Thus the localization of activated CaMKII within a spine will affect the expression of LTP. The translocation of activated CaMKII to PSD was reported. Here we investigated the localization of activated CaMKII in a model dendritic spine, and found that the diffusion of calmodulin and calcineurin but not CaMKII contribute to the localization of activated CaMKII near PSD. This will offer an additional mechanism for the localization.
localization calmodulin spine camkii synaptic plasticity