Halogen bonding in complexes of proteins and non-natural amino acids
We have analyzed the influence of halogen bonding to the stability of complexes of proteins and non-natural amino acids. We employed conservation pattern, structural motif, secondary structure, and solvent accessibility calculation. The roles of key residues and geometry of interactions are also be elucidated. Results from this study will provide valuable insight into rational drug design.
halogen bonding complexes proteins non-natural amino acids stabilization centers