Lack of Proopiomelanocortin Peptides Results in Obesity and Defective Adrenal Function but Normal Melanocyte Pigmentation in the Murine C57BL/6 Genetic Background
Mice deficient in proopiomelanocortin peptides (Pomc?/?) generated on a 129 (Aw/ Aw) genetic background were back-crossed onto the C57BL/6 (a/a) genetic background. These mice exhibited most of the phenotypic characteristics previously reported on the 129 genetic background (Yaswen et al. 1999. Nat. Med. 5
obesity adrenal pigmentation proopiomelanocortin (pomc) hypothalamic-pituitary-adrenal axis (hpa) corticosterone