Involvement of Protein Kinase C in the PACAP-Induced Differentiation of Neural Stem Cells into Astrocytes
Expression of members of the conventional protein kinase C (cPKC) family in the differentiation of mouse neural stem cells (NSCs) induced by pituitary adenylate cyclase-activating polypeptide (PACAP) was investigated. In particular, expression of the ? and ? subtypes of cPKC in NSCs was observed. In response to activation by PACAP, cPKC? transiently increased twofold by day 2 and returned to basal levels by day 4, suggesting that cPKC? might be responsible for the differentiation process
differentiation neural stem cell astrocyte pituitary adenylate cyclase-activating polypeptide progenitor cell