An effective method for refining predicted protein complexes based on protein activity and the mechanism of protein complex formation
Identifying protein complexes from protein-protein interaction network is fundamental for understanding the mechanism of cellular component and protein function. At present, many methods to identify protein complexes are mainly based on the topological characteristics or the functional similarity features, neglecting the fact that proteins must be in their active forms to interact with others and the formation of protein complex is following a just-in-time mechanism.
refining protein activity just-in-time protein complex formation model gene expression