Dynamical behaviors of an HBV infection model with logistic hepatocyte growth
In this paper, a hepatitis B virus (HBV) infection model with logistic hepatocyte growth is investigated, and the basic reproduction number of HBV determining the extinction and the persistence of infection is obtained. When the basic reproduction number is less than one, the infection becomes extinct eventually; when the basic reproduction number is greater than one, the infection becomes persistent in vivo. Hopf bifurcation surface determining the stability of the chronic infection equilibrium is found, and the effect of all the parameters on stability of the chronic infection equilibrium is also discussed. (C) 2011 Published by Elsevier Ltd
hbv persistence hopf bifurcation viral dynamics