Vitamin E Mediates Cell Signaling and Regulation of Gene Expression
?-Tocopherol modulates two major signal transduction pathways centered on protein kinase C and phosphatidylinositol 3-kinase. Changes in the activity of these key kinases are associated with changes in cell proliferation, platelet aggregation, and NADPH-oxidase activation. Several genes are also regulated by tocopherols partly because of the effects of tocopherol on these two kinases, but also independently of them. These genes can be divided in five groups
vitamin e gene expression signal transduction ?-tocopherol (tocopherols tocotrienols) cell regulation inhibition of cell proliferation transcription factor receptor