TNF? Potentiates 2-Methoxyestradiol-Induced Mitochondrial Death Pathway
Ewing sarcoma cells are resistant to TNF?-induced cell death and this resistance results from the activation of the transcription factor NF-?B. Here, we investigated whether NF-?B activation interferes with 2-Me-induced cell death signaling in Ewing sarcoma cells and we examined the effect of treatment of these cells with 2-Me either alone or in combination with TNF?. Our results show that TNFa cooperates with 2-Me to induce apoptosis in Ewing tumor cells through mitochondrial cell death signaling. These results suggest that the use of TNF? in combination with 2-Me may be beneficial for Ewing tumor treatment.
tnf? nf-?b apoptosis 2-methoxyestradiol mitochondria