Stat and interferon genes identified by network analysis differentially regulate primitive and definitive erythropoiesis
Hematopoietic ontogeny is characterized by overlapping waves of primitive, fetal definitive, and adult definitive erythroid lineages. Our aim is to identify differences in the transcriptional control of these distinct erythroid cell maturation pathways by inferring and analyzing gene-interaction networks from lineage-specific expression datasets. Inferred networks are strongly connected and do not fit a scale-free model, making it difficult to identify essential regulators using the hub-essentiality standard.
definitive erythropoiesis primitive erythropoiesis stat1 stat3 ifn-signaling gene-regulatory networks co-expression network inference