Exploring the relationship between hub proteins and drug targets based on GO and intrinsic disorder
The relationship between hubs and drug targets was investigated. Intrinsic disorder and semantic similarity were used for PPI representation. Only 8-dimensional features fully characterize the PPI information. The model gives a good performance in predicting PPIs and identifying drug targets. We prove that both hubs and intrinsic disorder proteins are potential drug targets.
drug target intrinsic disorder proteinprotein interactions (ppis) gene ontology (go) terms