Investigation of factors affecting hypothermic pelvic tissue cooling using bio-heat simulation based on MRI-segmented anatomic models
This study investigated the influence of different pelvic tissue types as well as the choice of thermal property parameters on the efficacy of endorectal cooling balloon (ECB). Prostate size and periprostatic venous plexus were two major factors affecting ECB cooling efficiency. Large prostate made the cooling difficult to propagate through the prostate. Patients with abundant periprostatic venous plexus required a longer time for neurovascular bundle (NVB) cooling. This feasibility study demonstrated that the simulation tool could potentially be used for adjusting the setting of ECB for hypothermic radical prostatectomy.
mri magnetic resonance imaging ecb endorectal cooling balloon 2d two-dimensional nvb neurovascular bundle psa prostate specific antigen nfs-t2wi non-fat-saturated t2 weighted images fs-t2wi fat-saturated t2 weighted images fse fast spin echo fov field of view tr repetition time te echo time p prostate gland rw rectal wall rf peri-rectal fatty tissue pf peri-prostatic fatty tissue pv peri-prostatic venous plexus b urinary bladder roi region of interest fem finite element model hifu high-intensity focused ultrasound 3d three-dimensional iv intravenous liit laser induced interstitial thermotherapy