Postprandial response improvement via safety layer in closed-loop blood glucose controllers
The paper presents and intensively evaluates a method for reducing the incidence of postprandial hypoglycemia in patients with type 1 diabetes. The method adapts the glucose set-point when the insulin-on-board estimation reaches a given clinical constraint. Through a very challenging test scenario it is shown that the method not only reduces the hypoglycemia events but also allows reducing the postprandial glucose excursion.
postprandial safety layer glucose control hypoglycemia insulin-on-board artificial pancreas constrained control sliding mode control