Automatic signal extraction, prioritizing and filtering approaches in detecting post-marketing cardiovascular events associated with targeted cancer drugs from the FDA Adverse Event Reporting System (FAERS)
Targeted cancer drugs are often associated with unexpectedly high cardiotoxicity. The Mechanisms underlying these drugcardiovascular (CV) relationships are unclear. Systems approaches in studying targeted cancer drugCV relationships are important. There exists no knowledge base of targeted drugCV relationships. We extract, rank, filter, and curate post-marketing drugCV pairs from FAERS.
cardiotoxicity targeted cancer therapy data mining post-market drug safety surveillance personalized medicine