Transcriptional regulation prediction of antiestrogen resistance in breast cancer based on RNA polymerase II binding data
Although endocrine therapy impedes estrogen-ER signaling pathway and thus reduces breast cancer mortality, patients remain at continued risk of relapse after tamoxifen or other endocrine therapies. Understanding the mechanisms of endocrine resistance, particularly the role of transcriptional regulation is very important and necessary.
transcriptional regulation antiestrogen resistance rna polymerase ii prediction of tfs