Ventricular fibrillation mechanisms and cardiac restitutions: An investigation by simulation study on whole-heart model
Effects of restitutions on ventricular fibrillation (VF) were examined insilico. Action potential duration restitution (APDR) heterogeneity causes mother-rotor VF. The effect of conduction velocity restitution on VF depends on the APDR Conversion of two types of VF was successfully simulated.
apd action potential duration apdr action potential duration restitution cv conduction velocity cvr conduction velocity restitution d600 methoxyverapamil df dominant frequency di diastolic intervals erp effective refractory period fft fast fourier transform foi frequency of interest fpaz the r-value of the first peak after zero of the autocorrelation function lr luorudy model mf median frequency rv right ventricle scd sudden cardiac death shd structural heart diseases spw spectral width vf ventricular fibrillation vt ventricular tachycardia