Monte Carlo simulation of photon migration in multi-component media
A Monte Carlo model of steady-state light transport in multi-layered tissues had been compiled in C language so that it could be applied on various computers easily. In the standard model of photon transport in a semi-infinite geometry, only a group of optical parameters are employed (the absorption coefficient, the scattering coefficient and the anisotropy factor). In order to properly simulate the multi-component media, we proposed a modified model in which we gave each component a weight based on its percentage composition in every layer of tissue or complex solution, while the MCML model [Monte Carlo model of light transport in multi-layered tissues by Wang et al. (Comput Meth Prog Biol 47:131146, 1995)] cannot directly simulate the photon migration in multi-component media. The computational results using the modified model have been validated by existing analytical methods and the experiment. We have adopted the partial least-squares regression to measure the inner components percentage of the model solution of biological tissue, the percentage errors of both the calibration and prediction were \(>\)1%. It has been proven that the modified model is able to effectively simulate the multi-component media. It also has a potential advantage to be a valid method for relevant applications in biomedical optics.
monte carlo simulation photon migration multi-component media biomedical optics the random statistics