Caspase Inhibitors as a Supplement in Immune Activation Therapies to Achieve Eradication of HIV in Its Latent Reservoirs
Synthetic caspase inhibitors are known to block death receptor-induced apoptosis. We have reported previously that in addition to apoptosis inhibition, caspase inhibitors induce a switch from proapoptotic to proinflammatory signaling in T cells. This switch sensitizes TNF-R1 to trigger TNF-?-induced reactivation of HIV in latently infected T cells. Here we ponder the prospects of caspase inhibitors as a supplement in immune activation therapies (IAT) to achieve eradication of HIV from the latent virus reservoirs in HIV-infected patients.
caspase inhibitors eradication hiv apoptosis tnf-r1 reactivation