Dynamics of the HPA axis and inflammatory cytokines: Insights from mathematical modeling
A 5-D model of the interaction between the HPA axis and immune system is introduced. This work models the dynamics of TNF-a, IL-6, ACTH and cortisol in LPS injection. The model captures the main qualitative features of cytokine and hormone dynamics. The role of HPA axis in transition from acute to prolonged inflammation is analyzed
inflammatory cytokines mathematical model immune system nervous system hypothalamic-pituitary-adrenal (hpa) axis