Early Activation of Antioxidant Mechanisms in Muscle of Mutant Cu/Zn-Superoxide Dismutase-Linked Amyotrophic Lateral Sclerosis Mice
A subset of familial ALS cases is associated with missense mutations in the gene encoding Cu/Zn-superoxide dismutase (SOD1), a free radical scavenging enzyme that protects cells against oxidative stress. Overexpression of these ALS-linked mutations confers an unidentified gain of function to the enzyme that triggers a series of neurological disorders characteristic of human ALS. To understand how skeletal muscle may counteract the progression of the disease, we explored the expression of different molecular effectors involved in antioxidant pathways. Our results are strongly indicative of the early and long-lasting activation of a series of molecular effectors thought to act coordinately in preventing the increased oxidative stress characteristic of ALS.
amyotrophic lateral sclerosis sod1 oxidative stress axotomy c-jun gastrocnemius muscle ?-glutamylcysteine synthetase glutathione peroxidase nrf-2