FreeContact: fast and free software for protein contact prediction from residue co-evolution
20years of improved technology and growing sequences now renders residue-residue contact constraints in large protein families through correlated mutations accurate enough to drive de novo predictions of protein three-dimensional structure. The method EVfold broke new ground using mean-field Direct Coupling Analysis (EVfold-mfDCA); the method PSICOV applied a related concept by estimating a sparse inverse covariance matrix. Both methods (EVfold-mfDCA and PSICOV) are publicly available, but both require too much CPU time for interactive applications. On top, EVfold-mfDCA depends on proprietary software.
evfold psicov protein structure prediction protein sequence analysis fast protein contact prediction 2d prediction open-source software evcouplings mfdca bioxsd debian package