Determining the bistability parameter ranges of artificially induced lac operon using the root locus method ?
We use root locus method to determine bistability parameter ranges for lac operon. The method captures parameter ranges ensuring triple roots to equilibrium equation. Analyzing gene regulatory networks under parameter uncertainties is achieved. Bistability ranges for TMG- and IPTG-induced lac operon models are obtained. The method is applicable to any biological model based on mass action kinetics.
bistability lac operon root locus tmg iptg