Testing equality of risk ratios in multiple 2 x 2 tables with structural zero
This paper investigates the equality test of risk ratios in multiple 2 x 2 tables with structural zero which is formed by a confounding factor such as age gender severity of disease region or other variables of Interest Score statistic Wald statistic and likelihood ratio statistic for testing equality of risk ratios in multiple 2 x 2 tables with structural zero e proposed Three procedures for calculating p-values of the above three statistics based on the MaxT MinP and Bonferroni methods are developed An algorithm for determining sample size required for attaining the pre-specified power is presented Empirical results show that (1) likelihood ratio statistic and score statistic via the MaxT and MinP methods be have satisfactorily in the sense that their type I error rates are close to the pre-given significance level (2) the Wald-type statistic with logarithmic transformation behaves better than the Wald-type statistic Simulation studies and a real example are used to Illustrate the proposed methodologies (C) 2010 Elsevier B V All rights reserved
2 x 2 table with structural zero equality test likelihood ratio statistic multiple testing procedure score test