Combinatorial control of ATF4-dependent gene transcription in osteoblasts
Osteoblast-specific gene transcription requires interaction between bone cellspecific transcription factors and more widely expressed transcriptional regulators. This is particularly evident for the basic domain-leucine zipper factor activating transcription factor 4 (ATF4), whose activity can be enhanced or inhibited through interaction with other leucine zipper proteins, intermediate filament proteins, components of the basic transcriptional machinery, nuclear matrix attachment molecules, or ubiquitously expressed transcription factors. We discuss the results supporting the relevance of these interactions and present the first evidence of a functional interaction between ATF4, FIAT (factor-inhibiting ATF4-mediated transcription), and ?NAC (nascent polypeptide-associated complex and coactivator alpha), three proteins that have been previously shown to associate using various proteinprotein interaction assays.
atf4 transcription osteoblast fiat ?nac