Comparative multi-goal tradeoffs in systems engineering of microbial metabolism
Metabolic engineering design methodology has evolved from using pathway-centric, random and empirical-based methods to using systems-wide, rational and integrated computational and experimental approaches. Persistent during these advances has been the desire to develop design strategies that address multiple simultaneous engineering goals, such as maximizing productivity, while minimizing raw material costs.
metabolism metabolic engineering microorganisms constraint-based modeling