data mining of mrna-seq and small rna-seq data to find microrna targets
The computational identification of miRNA target sites in an mRNA transcript is a challenging problem. In this paper, we describe an integrative approach to efficiently predict the miRNA:mRNA interactions by data-mining of massive parallel sequencing based data, such as mRNA-Seq and small RNA-Seq, and transcript isoform specific miRNA binding scores of miRanda algorithm.
rna-seq small rna-seq microrna mirna mcf-7 human breast cancer