Inferring ancient metabolism using ancestral core metabolic models of enterobacteria
Enterobacteriaceae diversified from an ancestral lineage ~300-500 million years ago (mya) into a wide variety of free-living and host-associated lifestyles. Nutrient availability varies across niches, and evolution of metabolic networks likely played a key role in adaptation.
ancient metabolism ancestral core enterobacteria constraint-based modeling metabolic network reconstruction paleo systems biology