Decoding the EGFR mutation-induced drug resistance in lung cancer treatment by local surface geometric properties
A method for predicting the EGFR mutation-induced drug resistance is proposed. Four types of local surface changes are defined for the mutants compared with wild-type EGFR. Three types of the changes have strong correlation with the progression-free survival (PFS). The number of convex shapes also shows a correlation with the PFS.
drug resistance lung cancer egfr mutation alpha shape solid angle protein surface geometric properties