Effects of Methyllycaconitine and Related Analogues on Bovine Adrenal ?3?4* Nicotinic Acetylcholine Receptors
Adrenal secretion and binding studies were performed using ring E analogues of methyllycaconitine to assess structural determinants affecting activity on bovine adrenal ?3?4* nicotinic receptors. The most potent analogues are as potent as many inhibitors of adrenal secretion. Our data support the potential use of methyllycaconitine analogues to generate nicotinic receptor subtype-specific compounds.
methyllycaconitine adrenal ?3?4 nicotinic acetylcholine receptors mla