Efficient prediction of protein conformational pathways based on the hybrid elastic network model
We developed hybrid elastic network (HENM) model based on rigid cluster model. HENM has been applied to both normal mode analysis and pathway generation. The simulation results of selected proteins and ribosome show the robustness and reliability of the model. HENM is expected to improve the computational efficiency of elastic network model.
elastic network model normal mode analysis pathway generation protein dynamics elastic network interpolation