Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations ?
In Part 1, we discuss state-of-the-art methods used to model cardiac optogenetics. Required techniques at the protein, cell, tissue, and organ scales are summarized. A novel exploration of optogenetic cardiac action potential silencing is included. In Part 2, we review findings that have emerged from cardiac optogenetics modeling. Simulations will help assess the efficacy of potential clinical applications.
cardiac optogenetics cardiac arrhythmia multiscale computational simulations optical stimulation light attenuation viral gene delivery cell delivery