Andrographolide: A potent antituberculosis compound that targets Aminoglycoside 2?-N-acetyltransferase in Mycobacterium tuberculosis
The Anti-tuberculosis activity of Andrographis paniculata was screened using Luciferase Reporter Phage Assay (LRP). Based on the bioassay guided fractionation, Andrographolide has been identified as an active molecule. The probable drug target for Andrographolide was identified by using docking analysis. Molecular simulation was performed to refine the targetdrug complex.
andrographolide tuberculosis drug target docking molecular simulation antimycobacterial activity