PhenoPredict: A disease phenome-wide drug repositioning approach towards schizophrenia drug discovery
Schizophrenia (SCZ) is among the most enigmatic disorders without curative drugs. Systems approaches to study phenotypic interconnections among diseases can lead novel drug discovery. We developed a phenome-wide systems drug repositioning approach for SCZ. Our approach is effective in finding FDA-approved SCZ drugs as well as in novel predictions. Our algorithm performed significantly better than one of most comprehensive drug repositioning system.
drug repositioning schizophrenia drug discovery systems biology disease phenotype