TRANSCUTANEOUS FOCAL ELECTRICAL STIMULATION VIA CONCENTRIC RING ELECTRODES REDUCES SYNCHRONY INDUCED BY PENTYLENETETRAZOLE IN BETA AND GAMMA BANDS IN RATS
Epilepsy is a neurological disorder that affects approximately one percent of the world population. Antiepileptic drugs are ineffective in 25 similar to 30% of cases. Electrical stimulation to control seizures may be an additive therapy. We applied noninvasive transcutaneous focal electrical stimulation (TFES) via concentric ring electrodes on the scalp of rats after inducing seizures with pentylenetetrazole. We found a significant increase in synchrony within the beta-gamma bands during seizures and that TFES significantly reduced the synchrony of the beta-gamma activity and increased synchrony in the delta band.
electrical stimulation synchrony epilepsy seizure beta-gamma band coherence