Expression of Gonadotropin ?, Follicle-stimulating Hormone ?, and Luteinizing Hormone ? Genes of the Hermaphroditic Fish Kryptolebias marmoratus Exposed to Octylphenol, 17? Estradiol, and Tamoxifen
In order to study the expression of the gonadotropin ? subunit and ? subunit [follicle-stimulating hormone (FSH)-? and luteinizing hormone (LH)-?] cDNAs in the hermaphroditic fish Kryptolebias marmoratus, we cloned these genes and analyzed their modulatory effects in the brain/pituitary tissue after exposure to 17? estradiol (E2), tamoxifen (TMX), and octyphenol. Gonadotropin ? subunit (FSH-? and LH-?) showed E2-dependent upregulation in most hermaphrodites, whereas TMX did not show elevated expression. Octyphenol also showed a similar effect of upregulation on FSH-? expression but not for the LH-? gene. These results suggest that the expression of FSH-? and LH-? in K. marmoratus is associated with their expression on endocrine-disrupting chemicals in this species.
gonadotropin ? kryptolebias marmoratus octylphenol fsh-? lh-?