A systems biology analysis of brain microvascular endothelial cell lipotoxicity
Neurovascular inflammation is associated with a number of neurological diseases including vascular dementia and Alzheimers disease, which are increasingly important causes of morbidity and mortality around the world. Lipotoxicity is a metabolic disorder that results from accumulation of lipids, particularly fatty acids, in non-adipose tissue leading to cellular dysfunction, lipid droplet formation, and cell death.
activating transcription factor 3 microarray triglyceride-rich lipoprotein bloodbrain barrier