A mathematical model for projecting the replenishment of compounds in a sample bank
Sample banks are repositories of compounds that are screened for therapeutic potential in the drug discovery process. Effectively managing a sample bank requires good intelligence to plan the storage of compounds and the workload of personnel and equipment. We help address this concern with a mathematical model to project compound depletion and replenishment as a function of screening activity and compound copy count. The model is deterministic and formulated in terms of probabilities. Its results show good agreement with those of randomization-based simulations of sample bank operations. This suggests that the model produces reliable projections. (c) 2013 Elsevier B.V. All rights reserved.
sample bank probability compound management high throughput screening inventory replenishment