The Role of Mitogen-Activated Protein Kinases and Their Relationship with NF-?B and PPAR? in Indomethacin-Induced Apoptosis of Colon Cancer Cells
We have evaluated the role of mitogen-activated protein kinases (MAPKs) and their relationship with nuclear factor ?B (NF-?B) and peroxisome proliferator-activated receptor ? (PPAR?) in indomethacin-induced apoptosis of colon cancer cells. We demonstrated that indomethacin can induce the prolonged activation of MAPKs in colon cancer cells; and that of these MAPKs, p38 MAPK may play a partial but significant role in indomethacin-induced apoptosis. Furthermore, indomethacin-induced p38 MAPK-mediated apoptosis of colon cancer cell lines is independent of caspase activation and not associated with indomethacin-induced NF-?B suppression and PPAR? activation.
mitogen-activated protein kinases indomethacin apoptosis