Identification of parameter correlations for parameter estimation in dynamic biological models
One of the challenging tasks in systems biology is parameter estimation in nonlinear dynamic models. A biological model usually contains a large number of correlated parameters leading to non-identifiability problems. Although many approaches have been developed to address both structural and practical non-identifiability problems, very few studies have been made to systematically investigate parameter correlations.
parameter correlation parameter estimation identifiability data sets with different inputs zero residual surfaces experimental design