COMPUTER SIMULATION FOR THE CROSSING TIME IN A DIPLOID, ASYMMETRIC, SHARPLY-PEAKED LANDSCAPE IN THE INFINITE POPULATION LIMIT
This study calculated the crossing time in the diploid mutation - selection model in an infinite population limit for various dominance parameters, h, and selective advantages, by switching on a diploid, asymmetric, sharply-peaked landscape, from an initial state which is the steady state in a diploid, sharply-peaked landscape. The crossing time for h   1 became saturated at a long sequence length. The crossing time decreased with increasing selective advantage, mainly because the larger selective advantage caused the increase in relative density of the reversal allele to grow exponentially at an earlier time.
crossing time infinite population diploid mutation - selection model dominance parameter asymmetric sharply-peaked landscape