Induction of Myasthenia Gravis in HLA Transgenic Mice by Immunization with Human Acetylcholine Receptors
We utilized HLA transgenic mice to identify the dominant epitopes on the human (H)-AChR ? subunit. The cytoplasmic H-AChR peptide ?320337 was the dominant T cell epitope for DQ8, DR3, and DQ8DQ6 F1 mice. The H-AChR-immunized HLA-DQ8, DR3, DQ8DR3 F1 and DQ8DQ6 F1 mice developed clinical EAMG, whereas HLA-DQ6 mice were less susceptible.
hla transgenic mice myasthenia gravis (mg) experimental autoimmune myasthenia gravis (eamg) achr