Metabolic network motifs can provide novel insights into evolution: The evolutionary origin of Eukaryotic organelles as a case study
We present a novel application of metabolic network motifs that can provide insights into evolution. We illustrate our novel application to investigate the ancestral origin of Eukaryotic organelles. Our preliminary analysis supports the hypothesis of an early proto-Eukaryote. Our analysis also suggests that a ?- or ?-Poteobacteria may have been the endosymbiotic partner that gave rise to modern mitochondria. We propose a methodology for constructing phylogenetic trees that incorporates metabolic network signatures.
metabolism network motifs evolution eukaryotic cell phylogenies enzyme classification