Effect of Agmatine on the Time Course of Brain Inflammatory Cytokines After Injury in Rat Pups
Pro-inflammatory cytokines play an important role in brain injury. Agmatine reduces brain injury. Does agmatine act by reducing cytokines? Seven-day-old rat pups had the right carotid artery ligated and then were subjected to 2.5 hours of 8% oxygen. Agmatine (100 mg/kg) or vehicle was administered at 5 minutes after reoxygenation. Cytokines were measured in the cortex by enzyme-linked immunosorbent assay. Interleukin (IL)-6, IL-1b, and tumor necrosis factor-alpha (TNF-a) were significantly increased after reoxygenation. Agmatine had no effect.
newborn ischemia hypoxia imidazoline agonist