Thymosin ?1
Thymosin ?1 (T?1), first described and characterized by Allan Goldstein in 1972, is used worldwide for the treatment of some immunodeficiencies, malignancies, and infections. Although T?1 has shown a variety of effects on cells and pathways of the immune system, its central role in modulating dendritic cell (DC) function has only recently been appreciated. As DCs have the ability to sense infection and tissue stress and to translate collectively this information into an appropriate immune response, an action on DCs would predict a central role for T?1 in inducing different forms of immunity and tolerance. Recent results have shown that T?
thymosin dendritic cells immunity and tolerance toll-like receptors regulatory t cells