Is a Pro12Ala Polymorphism of the PPAR?2 Gene Related to Obesity and Type 2 Diabetes Mellitus in the Czech Population?
The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor subfamily of transcription factors. PPAR?2 plays a key role in regulation of adipocyte differentiation and energy homeostasis. Recent studies provide evidence that the Pro12Ala polymorphism is linked to obesity and type 2 diabetes mellitus, but the results are controversial and depend on ethnicity. The aim of this study was to determine allele frequencies and to study the influence of the polymorphism on biochemical and anthropometric parameters in a Czech healthy adult population, in type 2 diabetics, and in a group of obese women. Results
pro12ala polymorphism ppar?2 gene type 2 diabetes mellitus obesity in humans