Coarse-grained optimization-driven design and piecewise linear modeling of synthetic genetic circuits
Optimization-based approach for coarse-grained design of synthetic genetic circuits. Qualitative description of basic biological parts used for the circuit design. Promoters and ribosome binding sites categorized as low, medium and high efficiency. Designed a genetic toggle switch, a 24 genetic decoder and a genetic half adder. Identified novel and non-intuitive as well as known circuit structures.
synthetic genetic circuits (b) bioinformatics piecewise linear differential equations integer linear program