Assessment of high-confidence proteinprotein interactome in yeast
The databases of interacting protein pairs for yeast are assembled. A huge protein interaction dataset comprising of 135154 interactions is obtained. An unsupervised statistical method to reduce the noise in interactome is proposed. The superiority of the proposed method over previous scoring schemes is showed. A highly reliable protein interaction network of yeast is reconstructed.
high-confidence yeast protein interaction network proteinprotein interactions saccharomyces cerevisiae