CD45 Knockout Mice, Diet, and Colitis: In the Absence of CD45, Colitis Follows Dietary Changes
Healthy CD45 KO mice show a Th2-type cytokine secretion profile in their small intestines. Dietary supplementation with human infant formula induced colitis and a shift toward a Th1-type profile, suggesting that diet can alter cytokine secretion.
cd45ko mice gut lymphocytes intestinal intraepithelial lymphocyte cytokines