visualization of neuronal fiber connections from dt-mri with global optimization
Diffusion Tensor MRI (DT-MRI) provides valuable 3D data describing diffusion characteristics of water molecules in the human brain. From DT-MRI, it is hoped that neuronal fiber connections among cortical regions can be reliably extracted and adequately interpreted. To achieve this goal, several significant challenges persist. In this paper, by means of dynamic programming we have developed a global fiber reconstruction algorithm enabling efficient visualization of neuronal connections queried by both the start and end points on the fly. Besides an inherent ability to handle noisy datasets, our algorithm also naturally addresses situations where neuronal fibers branch or cross each other. We demonstrate the efficacy of our approach with visualization of neuronal connections among activated brain cortical regions detected by functional MRI (fMRI).
dt-mri global optimization dynamic programming reconstruction fmri fiber tracking conditional probability and bayes rule