Structural and Functional Role of the ?-Strand Insert (?381390) in the Fibrinogen ?-Module
Study of the folding status of the fibrinogen ?-module (residues ?148411) revealed that its COOH-terminal ?-strand (residues ?381390), that is normally inserted into its central domain, can be removed without destroying its compact structure. Based on this and other observations we propose a pull out hypothesis that suggests a mechanism for the formation of transverse ?-? crosslinks in fibrin.
?-strand insert fibrinogen ?-module pull out hypothesis ?-? crosslinking