In vivo correlation between semi-quantitative hemodynamic parameters and Ktrans derived from DCE-MRI of brain tumors
Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) has become more and more widely applied in cancer diagnosis and treatment follow-up. Without complicated calculation, a semiquantitative parameter  modified initial area under the curve (mIAUCc)  was proposed for better correlation with volume transfer constant (Ktrans) by computer simulation. In this study, we aim to further investigate the correlation between mIAUCc and Ktrans in clinical. A total of 10 patients with brain tumors participated in this study and images were acquired by using a 3-Tesla clinical MR scanner. The results showed that mIAUCc was highly correlated with Ktrans with the correlation coefficient of 0.913. Although the ideals of Ktrans and mIAUCc are different, mIAUCc does the trick for brain tumors evaluations in DCE-MRI. It reveals that mIAUCc could be an alternative for physiological condition evaluation in DCE-MRI.  2012 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 22, 132136, 2012
magnetic resonance imaging initial area under the curve volume transfer constant dynamic contrast enhanced