G-NEST: a gene neighborhood scoring tool to identify co-conserved, co-expressed genes
In previous studies, gene neighborhoodsspatial clusters of co-expressed genes in the genomehave been defined using arbitrary rules such as requiring adjacency, a minimum number of genes, a fixed window size, or a minimum expression level. In the current study, we developed a Gene Neighborhood Scoring Tool (G-NEST) which combines genomic location, gene expression, and evolutionary sequence conservation data to score putative gene neighborhoods across all possible window sizes simultaneously.
gene neighborhood genomics gene expression computational biology gene duplication transcription cluster analysis gene cluster bioinformatics evolution