Comparison of time-frequency distribution techniques for analysis of spinal somatosensory evoked potential
Spinal somatosensory evoked potential (SSEP) has been employed to monitor the integrity of the spinal cord during surgery. To detect both temporal and spectral changes in SSEP waveforms, an investigation of the application of time-frequency analysis (TFA) techniques was conducted. SSEP signals from 30 scoliosis patients were analysed using different techniques; short time Fourier transform (STFT), Wigner-Ville distribution (WVD), Choi-Williams distribution (CWD), cone-shaped distribution (CSD) and adaptive spectrogram (ADS). The time-frequency distributions (TFD) computed using these methods were assessed and compared with each other. WVD, ADS, CSD and CWD showed better resolution than STFT. Comparing normalised peak widths, CSD showed the sharpest peak width (0.13 +/- 0.1) in the frequency dimension, and a mean peak width of 0.70 +/- 0.12 in the time dimension. Both WVD and CWD produced cross-term interference, distorting the TFA distribution, but this was not seen with CSD and ADS. CSD appeared to give a lower mean peak power bias (10.3% +/- 6.2%) than ADS (41.8% +/- 19.6%). Application of the CSD algorithm showed both good resolution and accurate spectrograms, and is therefore recommended as the most appropriate TFA technique for the analysis of SSEP signals.
spinal somatosensory evoked potential (ssep) time-frequency analysis (tfa) short time fourier transform (stft) wigner-ville distribution (wvd) choi-williams distribution (cwd) adaptive spectrogram (ads) intraoperative spinal cord monitoring cone shaped distribution (csd)