Seq2Ref: a web server to facilitate functional interpretation
The size of the protein sequence database has been exponentially increasing due to advances in genome sequencing. However, experimentally characterized proteins only constitute a small portion of the database, such that the majority of sequences have been annotated by computational approaches. Current automatic annotation pipelines inevitably introduce errors, making the annotations unreliable. Instead of such error-prone automatic annotations, functional interpretation should rely on annotations of reference proteins that have been experimentally characterized or manually curated.
web server functional interpretation reference protein sequence homology pubmed literature