Computational prediction of hybridization patterns between hepatitis C viral genome and human microRNAs
This study analyzed hybridization patterns between human microRNA (miRNA) and genomes of HCV. Selection of candidate miRNAs based on minimum free energy (MFE) and hybridization pattern. hsa-miR-24-3p, hsa-miR-624-3p and hsa-miR-1915-5p were found to target multiple genotypes of HCV. The predicted miRNAs targeting HCV might be useful and have a potential role for inhibition of viral replication.
hybridization micrornas hepatitis c virus