New Molecular Mechanisms of Duodenal Ulceration
Stress is a major etiologic factor in the pathogenesis of gastric and duodenal ulceration, as first described in rats by Hans Selye. In patients with peptic ulcers duodenal ulcers are more frequent than gastric ulcers (except in Japan). Thus, our research during the last three decades focused on the molecular mechanisms of duodenal ulcer in rodent models of chemically induced duodenal ulceration, and here we review our three recent finding
duodenal ulceration endothelin-1 early growth response 1 angiogenesis vegf endostatin/angiostatin