Simulating the temporal evolution of neuronal discharge ?
Computer simulation was employed to explore the discharge behavior of one- and two-compartment models of a cerebellar Purkinje cell in response to climbing fiber and current pulse stimulation. We could not find a unique parameter set for any model that replicated the full temporal detail of reported discharge patterns. However, simplified composite models gave a better match than those employing HodgkinHuxley (HH)-type conductances. The better match achieved by the simpler models suggests that the composite level of description is well suited to simulation of the temporal detail required for the realistic simulation of large-scale neuronal networks.
purkinje cell composite model hodgkinhuxley model temporal discharge patterns