PLC?2: where bone and immune cells find their common ground
Identifying common signaling pathways to bone and immune system may lead to better therapeutic approaches in diseases such as inflammatory arthritis. In this context, PLC?2 seems to be a promising target. PLC?2 modulates bone homeostasis by affecting osteoclast recruitment and function. Via its catalytic activity and the adapter domains, PLC?2 controls RANKL and ?v?3 integrin-dependent signaling pathways in the resorbing cell. Thus, mice lacking PLC?2 are osteopetrotic. PLC?2 also regulates neutrophil degranulation after ?2 integrin-dependent attachment. Indeed PLC?2?/? mice are protected from K/BxN serum transfer arthritis, which is known to require neutrophil activation. These studies position PLC?2 as a critical regulator of the cellular and molecular mechanisms occurring in bone and immune cells during autoimmune inflammation.
plc?2 bone inflammation arthritis osteoclasts neutrophils