Structural and functional impact of missense mutations in TPMT: An integrated computational approach
Pathogenecity of TPMT mutations could be predicted by an integrative approach. Most of the mutations resulting in no enzyme activity are in conserved positions. Missense mutations have different effects on TPMT structure and function. Residue interaction network of approximately 85% of the alleles are different from wild type. Cytoscape is a robust program for visualization of residue interaction network in TPMT.
missense mutations tpmt bioinformatic analysis structure-function relationship