Fibrillar and Oligomeric ?-Amyloid as Distinct Local Biomarkers for Alzheimer's Disease
?-amyloid is a key component of Alzheimer's disease (AD) pathology. Researchers in both academic and industry are actively pursuing the development of imaging tracers and techniques to noninvasively measure local levels of ?-amyloid in the Alzheimer's brain. This presentation summarizes recent data and discusses the opportunities and challenges of imaging plaques containing fibrillar ?-amyloid for the early diagnosis and therapeutic monitoring of amyloid targeted therapies. Further, the value and feasibility of measuring the recently described soluble oligomeric form of ?-amyloid as an alternative noninvasive biomarker is also discussed
biomarkers alzheimer's imaging plaque ?-amyloid imaging ?-amyloid oligomers soluble ?-amyloid