Effects of Homocysteine on the Cellular Responses of Murine Endothelial Cells Cultured in Vitro
Homocysteine, derived from the metabolism of methionine, is claimed as a proatherogenic factor that leads to vascular dysfunction. To gain better insight into the molecular mechanisms involved, homocysteine was tested on a model of murine endothelial cells cultured in vitro, using a prototype DNA chip. The DNA chip was designed to follow the expression at the mRNA level of some major proinflammatory genes; TNF-? was used as a positive control.
hyperhomocysteinemia atherosclerosis endothelial dysfunction dna microarray