Molecular descriptors calculation as a tool in the analysis of the antileishmanial activity achieved by two series of diselenide derivatives. An insight into its potential action mechanism
We describe the study carried out for antileishmanial diselenides. Structural changes can modulate the release of the active fragments. The conformational behavior proves to be of great importance in target activity. The antileishmanial activity might be related with a modulation of redox system.
molecular descriptors diselenide leishmania diselenosulfonamides sar