Early Effects of Modulating Nuclear Factor-?B Activation on Traumatic Spinal Cord Injury in Rats
Abstract: Genes regulated by NF-?B play an important role on secondary damage and repair after spinal cord injury (SCI). To assess the early effects of the pharmacological inhibition and overactivation of NF-?B, pyrrolidine dithiocarbamate (PDTC) or lipopolysaccharide were given to rats before or after SC contusion. The amount of spared SC tissue was higher (P < 0.05) at 24 h postinjury in rats posttreated with PDTC; both PDTC-treated rats showed no significant trend to decrease polymorphonuclear infiltrate. p65 subunit was present in inflammatory cells, neurons, and astrocytes at the injury site. These data support further investigation on functional effects of NF-?B inhibition in acute SCI.
spinal cord injury (sci) pyrrolidine dithiocarbamate lipopolysaccharide inflammation nuclear factor-?b (nf-?b) spared tissue