Mating Attenuates Aging-Associated Increase of Lipid Peroxidation Activity in C57BL/6J Mice
In the frame of the free-radical hypothesis of aging and literature data on increased life span of mated animals, we evaluated brain, kidney, and liver lipid peroxidation in C57Bl/6J mice of various ages and compared lipid peroxidation activity in mated and non-mated mice of both genders. An aging-associated increase (from 3 to 12 months of age) of lipid peroxidation, as measured by malonaldehyde and 4-hydroxyalkenals (MDA + HAE) levels, was observed in the liver and kidney, but not in the brain. Tissue MDA + HAE levels were lower in 12-month old mated mice (housed with animals of opposite gender from three to five months of age) than in 12-month old non-mated animals. There were no gender differences in the observed effect. It is suggested that mating might attenuate the increase of lipid peroxidation associated with aging.
mating lipid peroxidation c57bl/6j mice aging malonaldehyde and 4-hydroxyalkenal (mda+hae)