Role of the Hedgehog/Patched Signaling Pathway in Oncogenesis: A New Polymorphism in the PTCH Gene in Ovarian Fibroma
We compared the expression of target genes of Hedgehog/Patched signaling in ovarian fibromas and ovarian dermoids. We noted that high levels of SHH appear almost regularly, especially in dermoids, usually accompanied by increased expression of SMO. GLI overexpression does not coincide with that of PTCH. Loss of heterozygosity findings in the PTCH locus and increased expression of several genes in the pathway strongly suggest that the pathway is involved in both ovarian fibroma and dermoids.
hedgehog/patched signaling ptch ovarian fibromas ovarian dermoids shh smo gli1 ptch polymorphisms