Influence of dendritic topology on firing patterns in model neurons
Neuronal electrophysiology is influenced by both channel distribution and morphology. Distinguishing two sources of morphological variabilitymetrics and topologywe show that model neurons sharing the same channel densities and anatomical size can derive functional differentiation from their dendritic topology. Firing frequencies in these metrically reduced neurons show a strong correlation with both mean path length and total electrotonic transformed size of the dendritic tree. This dependency of spiking behaviour is robust to different modes of stimulation, different tapering powers, and the absence of active dendritic channels.
topology firing patterns morphology path length morpho-electrotonic transform