Transglutaminase-Mediated Crosslinking of Specific Core Histone Subunits and Cellular Senescence
We observed that the transglutaminase (tTGase) level and activity increased in aged rats and senescent primary fibroblasts, suggesting that the tTGase-mediated macromolecule crosslinking may play a mechanistic role during aging. Although preliminary, our in vitro experiment suggests that the target of tTGase is core histones
transglutaminase histones macromolecular crosslinking