Mechanisms Mediating Anti-CD3 Antibody Efficacy
Anti-CD3 antibody therapy, a promising clinical approach for the treatment of type 1 diabetes (T1D), was investigated using a mathematical model of T1D in the female nonobese diabetic (NOD) mouse. Analyses of model simulation results indicate that, in addition to the known direct effects of anti-CD3 antibody on T lymphocytes, two additional mechanisms are required for sustained disease remissio
diabetes remission ? cells antigen presenting cells 145-2c11 systems biology glucose control