Involvement of claudins in zebrafish brain ventricle morphogenesis
Zebrafish brain ventricle morphogenesis involves an initial circulation-independent opening followed by a blood flow and circulation-dependent expansion process. Zebrafish claudin-5a is required for the establishment of a neuroepithelialventricular barrier, which maintains the hydrostatic pressure within the ventricular cavity, thereby contributing to brain ventricle opening and expansion. In mammalia, several claudin family members, including claudin-3 and claudin-5, are expressed within microvessel endothelial cells of the bloodbrain barrier. Whether zebrafish brain ventricle morphogenesis provides a model for studying these claudins during early embryonic development was unknown. This review focuses on the expression and function of these zebrafish claudins during brain ventricle morphogenesis.
brain ventricle morphogenesis claudin-5a claudin-3 tight junction