Molecular modeling revealed that ligand dissociation from thyroid hormone receptors is affected by receptor heterodimerization
We investigated the effect of TR heterodimerization on T3 dissociation. TR heterodimerization causes complete loss of pathway I in TR ?-RXR LBD. The second dominant dissociation pathway switched after TR heterodimerization. Mechanisms of T3 egress were elucidated at atomic level.
thyroid hormone receptor dissociation pathway heterodimer molecular dynamics simulation ramd