Influence of the decay time of the GABAergic postsynaptic current on the spatial spread of network activity
The subunit composition of the GABAA receptor determines the decay time of the GABAergic inhibitory postsynaptic current (IPSC). In mice in which the ?1 subunit is deleted, the decay time is longer than in wild-type mice, while the spatial spread of activity in the visual cortex following local stimulation is reduced. Using a simple network model of the visual cortex, we show that this reduced spread of activity could be accounted for by the longer IPSC decay time. After local stimulation of the network, a patch of activity develops, the equilibrium size of which depends on the IPSC decay time.
network activity gabaa receptor ?1 subunit ipsc decay time spatiotemporal patterns