Genome-wide prediction of prokaryotic two-component system networks using a sequence-based meta-predictor
Two component systems (TCS) are signalling complexes manifested by a histidine kinase (receptor) and a response regulator (effector). They are the most abundant signalling pathways in prokaryotes and control a wide range of biological processes. The pairing of these two components is highly specific, often requiring costly and time-consuming experimental characterisation. Therefore, there is considerable interest in developing accurate prediction tools to lessen the burden of experimental work and cope with the ever-increasing amount of genomic information.
meta-predictor two-component signalling system protein-protein interactions protein-protein interaction predictions support vector machine web server genome context co-evolution