A parallel/distributed architecture for hierarchically heterogeneous web-based cooperative applications
A new class of applications is described which requires cooperation among diverse users in multiple data and problem instance domains. The hierarchy of parallelism includes heterogeneity within a single instance of the problem, homogeneity among subsets of users within a problem domain, and multiple problem domains which share computational resources. The particular problem of genetic linkage analysis is used to illustrate and implement the architecture. GenoMap, the first implementation of this system is being deployed for several groups of cooperating users at multiple institutions in a study to isolate the genomic locus of the controlling gene(s) in several diseases including autism.
distributed genetic linkage genomap socket server