Caspase-3 Activation, Bcl-2 Contents, and Soluble FAS-Ligand Are Not Related to the Inflammatory Marker Profile in Patients with Sepsis and Septic Shock
The current comparative investigation analyses markers of inflammation and apoptosis in peripheral blood of intensive care unit (ICU) patients with postoperative/posttraumatic SIRS (systemic inflammatory response syndrome), sepsis, severe sepsis, or septic shock. Inflammatory markers (C-reactive protein [CRP], cytokines, metalloproteinases [MMPs]) and soluble FAS-Ligand (sCD178) were determined in plasma, and apoptosis-relevant antigens such as active caspase-3, Bcl-2, and sCD178 were quantified in whole-blood cell lysates. These parameters were analyzed daily in 20 postoperative/posttraumatic patient
bcl-2 sepsis septic shock mmps soluble fas-ligand (scd178) whole-blood lysates active caspase-3 inflammatory cytokines tnf-? il-6