Complex between Human RNase HI and the phosphonate-DNA/RNA duplex: Molecular dynamics study
2001000ns MD simulations produced using GPU and the ACEMD software package. Biologically active 3pc5 phosphonate oligonucleotide binds to RNase H. Biologically inactive 3cp5 phosphonate oligonucleotide dissociates from RNase H. Glu512 completes the catalytic tetrad of Thermus thermophilus Argonaute.
phosphonate molecular dynamics acemd argonaute rnase h antisense oligonucleotides rnai