Modeling the Spreading Cortical Depression Wavefront
Spreading cortical depression (SCD) is a wave of depolarization that spreads across the cortex at 25 mm/min and is followed by a 510 minute reduction in EEG activity. It is assumed that SCD is involved in the pathophysiology of migraine. We present a new model and a visualization technique for the spread of excitation on realistic brain surfaces. The usefulness of the technique is demonstrated on a rat brain that had been segmented from a three-dimensional magnetic resonance image data set. With the help of this methodology it is possible to create specific patient models to better understand the mechanisms of SCD.
spreading cortical depression (scd) brain surface three-dimensional modeling magnetic resonance imaging (mri) magnetoencephalography (meg) electroencephalography (eeg) neurons