Barrett's esophagus: natural history
The following on the natural history of Barrett's esophagus (BE) includes commentary on histological sequences of the development of Barrett mucosa; the transformation of esophageal cells from squamous to columnar phenotype; the stages of natural history of dysplasia; the difficulties of predicting progression of dysplasia to adenocarcinoma; the preferable biopsy protocols; the role of?Helicobacter pylori?infection and gastric atrophy in the risk of BE; the value of decrease of proton pump inhibitor efficacy following eradication of?H. pylori; the place of antireflux surgery in the natural history of BE; the newest procedures for the endoscopic detection of early neoplasia; and the essential importance of a good understanding of the natural history for the best management of high-grade dysplasia.
barrett's esophagus adenocarcinoma adenocarcinoma biopsy protocol gastric atrophy high-grade dysplasia reflux cdx2 dilated intercellular spaces bile salts h. pylori gerd endoscopic grading system cag a-postive strain metaplasia laparoscopic surgery high resolution endoscopy narrow band imaging trimodal technology bimodal protocol esophageal metaplasia radiofrequency ablation endoscopic mucosal resection interobserver reproducibility