Simulation of five intracellular Ca2+ regulation mechanisms in response to voltage-clamp pulses
We report the simulation of five Ca2+ regulation mechanisms in response to voltage-clamp pulses applied at the membrane. We obtain the currents generated and also record the Ca2+ concentration changes in the whole cell during and after the pulse. Our simulator includes models for the L-type voltage-dependent Ca2+ channels, the Ca2+ pump, the Na+/Ca2+ exchanger and a fast buffering system, along with diffusion assuming a spheric cell shape. (C) 2003 Elsevier Ltd. All rights reserved.
simulation ca2+ regulation spheric cell voltage clamp calcium diffusion