Barrett's esophagus: progression to adenocarcinoma and markers
The following on progression to adenocarcinoma and markers of Barrett's esophagus includes commentariess on the expression of claudin 4 in Barrett's adenocarcinoma; the role of acid and bile salts; the role of insulin-like growth factor; the value of reactive oxygen species; the importance of abnormal methylation; genetic alterations in stromal cells and genomic changes in the epithelial cells; the value of confocal laser endomicroscopy for the subsurface analysis of the mucosa; indications for statins as adjuvant chemotherapeutic agent; the sequence of molecular events in malignant progression in Barrett's mucosa; and the value of the macroscopic markers and of p53 mutations.
barrett's esophagus claudin 4 confocal laser endomicroscopy squamous epithelium gerd acid exposure bile exposure carcinoma in vitro?transformation phenotype changes morphological changes cdx2 mrna expression p53 protein nox5 cox2 pge2 p16 aneuploidy tetraploidy ecle pcle hydroxymethyl-coa reductase inhibitors cyclooxygenase-2 inhibitors protein farnesyltransferase neoplastic progression