Intrinsic T Cell Defects in Systemic Autoimmunity
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of T cell tolerance to nuclear antigens. Studies in mice and humans have demonstrated that T cells from individuals with lupus are abnormal. Here, we review the known T cell defects in lupus and their possible biochemical nature, genetic causes, and significance for lupus pathogenesis.
autoimmunity systemic lupus erythematosus (sle) cd4 t cells anergy immunological tolerance