Simulation of a vertebrate receptor cell of the olfactory epithelium for use in network models ?
We developed a realistic model of a bipolar receptor cell of the olfactory epithelium. It has four compartments, namely cilia, dendritic knob, dendrite and soma. Cilia is a biochemical compartment including the molecular pathways of odor interpretation; dendrite is a passive compartment without channels; dendritic knob has Ca2+-dependent chloride channels; and soma has all channels of Traub's CA3 hippocampal pyramidal neuron model plus MoczydlowskiLatorre's BK channel model. A pool of molecular odors, which increase Ca2+ intracellular concentration and conductance of chloride channels, provides the input. The model's bursting behavior compares well with experimental data found in literature.
olfactory epithelium olfactory system olfactory receptor cell biochemical pathways