Models for H3 receptor antagonist activity of sulfonylurea derivatives
In the present study, a wide variety of 2D and 3D molecular descriptors (MDs) were successfully utilized for the development of models. Accuracy of prediction of proposed models developed through decision tree, random forest and moving average analysis varied from 88% to 95%. Proposed models offer vast potential for providing lead structures for development of potent but safe H3 receptor antagonist sulfonylurea derivatives.
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