Dendritic calcium signaling in cerebellar Purkinje cell
The Purkinje cells in the cerebellum are unique neurons that generate local and global Ca2+ 2 + signals in response to two types of excitatory inputs, parallel fiber and climbing fiber, respectively. The spatiotemporal distribution and interaction of these synaptic inputs produce complex patterns of Ca2+ 2 + dynamics in the Purkinje cell dendrites. The Ca2+ 2 + signals originate from Ca2+ 2 + influx through voltage-gated Ca2+ 2 + channels and Ca2+ 2 + release from intracellular stores that are mediated by the metabotropic glutamate receptor signaling pathway. These Ca2+ 2 + signals are essential for the induction of various forms of synaptic plasticity and for controlling the inputoutput relationship of Purkinje cells. In this article we review Ca2+ 2 + signaling in Purkinje cell dendrites.
parallel fiber climbing fiber synaptic plasticity ca2+ 2 + spikes 2+ 2 + 2+ 2 + 2 + synapse elimination patch-clamp recordings ca2+ 2 + imaging 2+ 2 + 2+ 2 + 2 +