Calcium as the associative signal for a model of Hebbian plasticity: application to multi-input environments
The sign and magnitude of bi-directional synaptic plasticity have been shown to depend on: the rate of presynaptic stimulation, the level of postsynaptic depolarization, and the precise relative timing between pre- and postsynaptic spikes. It has been proposed that these different induction paradigms can coexist, and be accounted for by a single learning rule that depends on the dynamics of intracellular calcium concentration. We extend this rule to a multi-synaptic environment, where collective properties such as cooperativity, competition and selectivity can be investigated.
calcium synaptic plasticity hebbian learning stdp nmda