Estimate hidden dynamic profiles of siRNA effect on apoptosis
For the representation of RNA interference (RNAi) dynamics, several mathematical models based on systems of ordinary differential equations (ODEs) have been proposed. These models consist of equations for each molecule that are involved in RNAi phenomena. Therefore, many real-value parameters must be optimized to identify the models. They also have many hidden variables, which cannot be observed directly through experimentation. Calculation of the values of the hidden variables is generally very difficult, if not impossible in some special cases. Identification of the ODE models is also quite difficult.
sirna rna interference ordinary differential equation preypredator model parameter estimation genetic algorithm