Combining multiple disambiguation methods for gene mention normalization
The rapid growth of biomedical literature prompts pervasive concentrations of biomedical text mining community to explore methodology for accessing and managing this ever-increasing knowledge. One important task of text mining in biomedical literature is gene mention normalization which recognizes the biomedical entities in biomedical texts and maps each gene mention discussed in the text to unique organic database identifiers. In this work, we employ an information retrieval based method which extracts gene mentions semantic profile from PubMed abstracts for gene mention disambiguation. This disambiguation method focuses on generating a more comprehensive representation of gene mention rather than the organic clues such as gene ontology which has fewer co-occurrences with the gene mention. Furthermore, we use an existing biomedical resource as another disambiguation method. Then we extract features from gene mention detection systems outcome to build a false positive filter according to Wikipedias retrieved documents. Our system achieved F-measure of 83.1% on BioCreative II GN test data.
gene mention normalization biocreative ii gene symbol disambiguation web-based kernel