Identifying targets of multiple co-regulating transcription factors from expression time-series by Bayesian model comparison
Complete transcriptional regulatory network inference is a huge challenge because of the complexity of the network and sparsity of available data. One approach to make it more manageable is to focus on the inference of context-specific networks involving a few interacting transcription factors (TFs) and all of their target genes.
transcription factor bayesian inference gene regulation gene regulatory network systems biology