Improving low-dose bloodbrain barrier permeability quantification using sparse high-dose induced prior for Patlak model
Interweaving the standard Patlak model with sparse high-dose induced prior. Construct location adaptive dictionary based on anatomical structure of the brain. Learn sparse high-dose induced prior from different patients without the need of accurate registration. Propose EM style iterative optimization for sparse high-dose induced Patlak model. Outperform Patlak model in low-dose BBBP estimation in terms of different metrics.
bloodbrain barrier permeability sparse high-dose induced prior patlak model radiation dose reduction