An Approach to Identification of Dynamic Model for Optimization of Fed-Batch Fermentation Processes
A computation procedure is developed for identification of dynamic model intended for solving the biomass growth-related optimization problems at fed-batch fermentation processes. The model identification relies on exploiting a versatile structure model that covers several particular structure models commonly used in bioprocess engineering practice. The model parameters are found by using experimental data of batch or fed-batch fermentation processes and a consecutive identification procedure, which includes preliminary estimation of the parameters. Practical application of the proposed procedure of model identification is demonstrated for solving the feed-rate optimization problem in fed-batch culture Escherichia coli.
optimization fed-batch fermentation process model identification