Structure- and context-based analysis of the GxGYxYP family reveals a new putative class of Glycoside Hydrolase
Gut microbiome metagenomics has revealed many protein families and domains found largely or exclusively in that environment. Proteins containing the GxGYxYP domain are over-represented in the gut microbiota, and are found in Polysaccharide Utilization Loci in the gut symbiont Bacteroides thetaiotaomicron, suggesting their involvement in polysaccharide metabolism, but little else is known of the function of this domain.
glycoside hydrolase protein family gut microbiota carbohydrate metabolism polysaccharide utilization locus pul protein function prediction jcsg 3d structure