Transferring functional annotations of membrane transporters on the basis of sequence similarity and sequence motifs
Membrane transporters catalyze the transport of small solute molecules across biological barriers such as lipid bilayer membranes. Experimental identification of the transported substrates is very tedious. Once a particular transport mechanism has been identified in one organism, it is thus highly desirable to transfer this information to related transporter sequences in different organisms based on bioinformatics evidence.
membrane transporter substrate functional classification blast hmmer meme tc classification system sequence homology