Macrophage Migration Inhibitory Factor and Activator Protein-1 in Ulcerative Colitis
Macrophage migration inhibitory factor (MIF) is a cytokine that has potent antisteroid effects. We determined that MIF is involved in the glucocorticoid-resistant inflammatory process of ulcerative colitis (UC), and the altered AP-1 signal is a potent therapeutic target for refractory UC.
glucocorticoids inflammatory bowel disease transcriptional factors