Recovery of the wild type atomic flexibility in the HIV-1 protease double mutants
We compare the CA atoms flexibility between the WT, single and double mutants by NMA. Flexibility profile of double mutants becomes more similar to that of WT. Single mutants showed a significant alteration in h-bond formation compared to WT. H-bond pattern of double mutants becomes more similar to that of WT.
hiv-1 protease double mutants molecular modeling normal modes analysis protein flexibility