Identification of novel allosteric modulator binding sites in NMDA receptors: A molecular modeling study
We generated the 3D models of full length NMDA receptor hetero-tetrameric structures. Using subunit selective allosteric modulators we identified four novel binding sites. We elucidated the influence of specific amino acid residues within each modulator binding site. Our insights contribute for the development of better drugs to treat neurological disorders.
allosteric modulators molecular modeling n-methyl-d-aspartate receptors (nmdars) d docking modulator binding sites (mbss)