An application of nonlinear optimization in molecular biology
A maximum likelihood approach has been proposed for finding protein binding sites on strands of DNA [G.D. Stormo, G.W. Hartzell, Proceedings of the National Academy of Sciences of the USA 86 (1989) 1183]. We formulate an optimization model for the problem and present calculations with experimental sequence data to study the behavior of this site identification method.
optimization molecular biology maximum likelihood protein binding nonlinear programming