title: The BIOGENES system for knowledge-based bioprocess control
abstract: The application of knowledge-based control systems in the area of biotechnological processes has become increasingly popular over the past decade. This paper outlines the structure of the advanced knowledge-based part of the BIOGENES Copyright control system for the control of bioprocesses such as the fed-batch Saccharomyces cerevisiae cultivation. First, a brief overview of all the tasks implemented in the knowledge-based level including process data classification, qualitative process state identification and supervisory process control is given. The procedures performing the on-line identification of metabolic states and supervisory process control (setpoint calculation and control strategy selection) are described in more detail. Finally, the performance of the system is discussed using results obtained from a number of experimental cultivation runs in a laboratory unit
keyphrases: BIOGENES system knowledge-based bioprocess control biotechnological processes fed-batch Saccharomyces cerevisiae cultivation process data classification qualitative process state identification supervisory process control metabolic states online identification experiment