Estudos comparativos entre Tobramicina Inalatória (TOBI) e Colistina na erradicação de Pseudomonas aeruginosa
Autor: Mauro Ferreira | Publicado: 2012-09-20T11:32:00-03:00








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<!--StartFragment-->







Uma publicação online da
CFNN (Cystic Fibrosis News Network) de 18 de setembro pp. apresentou uma discussão sobre novos
estudos comparativos entre Tobramicina inalatória vs Colistina na erradicação
da primeira infestação por Pseudomonas em pacientes com FC.&nbsp; Abaixo uma tradução livre do artigo que
mostoru eficácia semelhante entre a utilização dos dois produtos. &nbsp;Na publicação online também foi incluídos
comentários do Dr. Patrick Daigneault sobre o assunto.



Round Two: Inhaled
tobramycin vs. colistimethate 


Um recente estudo italiano demonstrou que a tobramicina inalatória
(TOBI)+ciprofloxacina oral e colistina inalatória+ciprofloxacina oral foram
comparavelmente eficazes na erradicação de uma primeira infecção de P. aeruginosa (Taccetti et al Thorax2012;. Epublished 29 de fevereiro de 2012). Erradicação foi obtida em 65,2% e
62,8% nos dois grupos de tratamento respectivamente.



Um estudo realizado na Bélgica relatou resultados similares
(Proesmans et al J Cisto Fibros 2012;. Epublished 02 de julho de 2012). Um
total de 58 crianças e adolescentes (idade média de 9 anos) com FC foram
randomizados para ciprofloxacina e&nbsp; TOBI
BID 300 mg por 28 dias ou colistimetato de sódio 2 x 2MU/dia por três meses em
pacientes com primeiro isolamento de P.
aeruginosa.



A taxa de eliminação foi similar com o regime de tratamento
de 1 mês com Tobramicina vs.&nbsp; 3 meses com
colistimetato. Erradicação foi alcançada em 23 de 29 pacientes (79,3%) tratados
com tobramicina / ciprofloxacina em comparação com 26 de 29 pacientes (89,6%)
tratados com colistimetato / ciprofloxacina. Esta diferença não foi
estatisticamente significativa.



Não houve diferença entre os dois grupos no índice de FVE1
ou de massa corporal em 1 ano de follow-up. Aos dois anos, a taxa de infecção
crônica por P. aeruginosa foi de 10%.
<!--EndFragment-->