Glicosídeos cardíacos
Autor: Lígia Martins | Publicado: 2011-10-05T17:47:00-07:00

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Os glicosídeos cardíacos aumentam a força de contração do miocárdio e diminuem a velocidade de condução através do nó atrioventricular. Esses efeitos são alcançados através da inibição da bomba de Na+/K+ e aumento da atividade vagal.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; São usados no tratamento da insuficiência cardíaca em pacientes que continuam sintomáticos, apesar da efetividade dos tratamentos anteriores, e para diminuir a freqüência em fibrilação atrial rápida persistente. Os efeitos adversos incluem náuseas, vômitos, diarréia e confusão.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; O principal glicosídeo cardíaco é a digoxina. O glucagon e alguns agonistas β1-adrenérgicos, como a dobutamina, também aumentam a contratibilidade do miocárdio.