ONCOGÊNESE MEDIADA PELO VÍRUS SÍMIO 40 (SV40)
Autor: Izabella Danezi Felin | Publicado: 2016-07-08T10:00:00-03:00

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ONCOGÊNESE MEDIADA PELO VÍRUS SÍMIO 40 (SV40)
O vírus símio 40 (SV40) é um Poliomavírus, cujo
hospedeiro natural é o macaco rhesus. Seu modo de transmissão ainda é pouco
conhecido, mas partículas virais presentes na urina contaminada do macaco podem
ser transmitidas via oral e/ou respiratória. A identificação do SV40 está
intimamente ligada ao desenvolvimento das vacinas de poliovírus inativada (VIP)
e da vacina do poliovírus oral atenuado (VOP), as quais foram produzidas a
partir de células renais do macaco rhesus infectadas pelo vírus. O SV40 é capaz
de infectar diversos tipos celulares, tanto em roedores quanto em primatas. O
hamster é o modelo animal utilizado no estudo da oncogênese mediada pelo SV40,
uma vez que estes são altamente suscetíveis aos tumores induzidos pelo vírus. O
espectro de tumores associados ao SV40 em humanos é o mesmo dos observados nos
roedores após a inoculação viral. O vírus símio 40 tem sido associado,
principalmente, a tumores de cérebro, osteossarcomas, linfomas não- Hodgkin e
mesoteliomas malignos. Nas células de roedores e de humanos suscetíveis ao
tumor, o SV40 não se replica, expressando somente seus genes precoces e
induzindo transformação maligna. O DNA viral é integrado ao cromossomo do
hospedeiro e proteínas denominadas antígenos T grandes são produzidas. Nos
tipos celulares sensíveis à oncogênese mediada pelo SV40, como as células
mesoteliais humanas, os antígenos (Ag-T) grandes parecem formar complexos com
algumas proteínas supressoras tumorais, como a p53 e pRB, inativando-as. Além
disso, os antígenos T grandes provenientes do vírus admitem a imortalização da
célula hospedeira, por meio da ativação da telomerase e dos oncogenes NOTCH-1,
Met e receptor de IGF-1. Diante disso, nessas amostras celulares, o SV40
comporta-se como um verdadeiro carcinógeno humano e não apenas como um
passageiro, sendo de extrema significância o papel por si desempenhado na
gênese de tumores humanos.