METÁSTASE DO FÍGADO
Autor: UNIVERSO PATOLÓGICO | Publicado: 2010-11-27T05:55:00-08:00

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O fígado é um órgão relativamente sólido e pesado (1.200 a 1.500 g), localizado no quadrante superior direito do abdome. Fica estrategicamente localizado de modo que praticamente todo o sangue que provém dos intestinos passa por ele. Desse modo, as substâncias que ingerimos passam por uma "inspeção" antes de serem encaminhadas ao restante do organismo. Se forem consideradas indesejadas, são transformadas em outras e descartadas na bile ou levadas pelo sangue para serem retiradas pelos rins na urina. Os remédios que ingerimos seguiriam o mesmo caminho, se não fossem engenhosamente feitos de modo a burlar essa defesa. O álcool passa pelo mesmo processo e é transformado para ser eliminado. O grande problema é que, se ingerido em grande quantidades, ao ser transformado torna-se ainda mais tóxico ao fígado, levando à destruição celular.
CÂNCER DE FÍGADOO câncer de fígado é dividido em duas categorias: o primário do fígado e o secundário, ou metastático (originado em outro órgão e que atinge também o fígado). O termo "primário do fígado" é usado nos tumores originados no fígado, como o hepatocarcinoma ou carcinoma hepatocelular (tumor maligno primário mais freqüente que ocorre em mais de 80% dos casos), o colangiocarcinoma (que acomete os ductos biliares dentro do fígado), angiossarcoma (tumor do vaso sangüíneo) e, na criança, o hepatoblastoma.O Hepatocarcinoma
O hepatocarcinoma (ou carcinoma hepatocelular - CHC) é o câncer primário do fígado, ou seja, o câncer derivado das principais células do fígado - os hepatócitos. Como os demais cânceres, surge quando há uma mutação nos genes de uma célula que a faz se multiplicar desordenadamente. Essa mutação pode ser causada por algum agente externo (como o vírus da hepatite B) ou pelo excesso de multiplicações das células (como a regeneração crônica nas hepatites), o que aumenta o risco de surgimento de erros na duplicação dos genes. O hepatocarcinoma é caracteristicamente agressivo, com altíssimo índice de óbito após o início dos sintomas (icterícia, ascite e outros). Se for detectado apenas na fase sintomática, o paciente tem expectativa de vida média inferior a um mês se não for realizado nenhum tratamento, sendo que nessa fase os tratamentos disponíveis são limitados e pouco eficazes.

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 <![endif]-->  O Colangiocarcinoma&nbsp;&nbsp; O colangiocarcinoma é o câncer derivado das células biliares, tanto no interior quanto no exterior do fígado (vesícula e ductos biliares). Surge principalmente em homens (3 homens para cada mulher), geralmente entre os 70 e 80 anos. A incidência dessa doença é de 2 a 2,8 casos a cada 100.000 pessoas. As pessoas de maior risco são aquelas portadoras de parasitas das vias biliares (raros no Brasil), colangite esclerosante primária (outra doença que pode levar à cirrose),colite ulcerativa (doença que leva a diarréia crônica, com episódios de sangramento, em adultos jovens) e cálculos biliares.<!--[if gte mso 9]>     Normal   0         21         false   false   false      PT-BR   X-NONE   X-NONE                                                                                                     <!--[endif]--><!--[if gte mso 9]>  <w:LatentStyles DefLockedState="false" DefUnhideWhenUsed="true"
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 <![endif]-->  Conclusão&nbsp;&nbsp; O fígado é um órgão de fundamental importância ao organismo e pode ser acometido por muitas doenças diferentes, a maior parte delas silenciosa. Os cânceres provenientes das vias biliares e de outros órgãos que metastatizam para o fígado tem um prognóstico mais reservado, também dependendo do estágio do tumor. Novamente, é de fundamental importância que o diagnóstico seja realizado rapidamente para melhorar as possibilidades de cura.
Acadêmicos de Enfermagem do 3º Período noturno FAESF:Iranilde SousaKarla Crystina UchôaRenata Klycia XavierSirlândia TocantinsTamilly Carneiro