Metabolismo absortivo e jejum 18/05
Autor: Akemi | Publicado: 2012-06-10T15:09:00-07:00







A nossa alimentação é importante para à
reposição de água, substratos energéticos, vitaminas e sais minerais. Mas como
o ser humano come de tempos em tempos ele reserva esses substratos. 



Tais reservas energéticas são
armazenadas como formas complexas:



<!--[if !supportLists]-->· <!--[endif]-->TRIGLICERÍDEOS
(ácidos graxos e glicerol)

<!--[if !supportLists]-->· <!--[endif]-->GLICOGÊNIO
HEPÁTICO E MUSCULAR (glicose/lactato)

<!--[if !supportLists]-->· <!--[endif]-->PROTEÍNAS
(aas glicogênicos)



Hormônios reguladores do metabolismo
energético



Fase catabólica -&gt; Suprarrenais ou
adrenais -&gt; cortisol e adrenalina

Fase anabólica -&gt; Pâncreas -&gt;
glucagon e insulina



Estado alimentado



Insulina -&gt; estoque de energia -&gt;
Glicose -&gt; Glicogênio hepático -&gt; fígado (glicogênese)

Insulina -&gt; estoque de energia -&gt;
ácidos graxos ( AGL) -&gt; triglicerídeos -&gt; tecido adiposo (lipogênese)

Insulina -&gt; estoque de energia -&gt;
aminoácidos -&gt; PTN -&gt; músculos (partenogênese)



Fase
anabólica 



ESTADO ABSORTIVO:&nbsp; Período de 2 a 4 horas após ingestão de
refeição normal. 

Ocorre: aumento no sangue da glicose, Aa
e Triglicérides. 

O pâncreas responde à elevação de
glicose e Aa com a liberação de insulina e redução de glucagon = ANABOLISMO

Neste período, praticamente todos os
tecidos usam glicose como combustível.



TECIDO ADIPOSO 

Grande sensibilidade do tecido adiposo à
insulina. Aumenta influxo de glicose (Mostrar animação da ação insulina)

Gliconeogênese diminuída 

&nbsp;Aumenta a síntese de ácidos graxos, TG.



GLUT – Transportador de Glicose



<!--[if !supportLists]-->· <!--[endif]-->Glut1
– Eritrócitos

<!--[if !supportLists]-->· <!--[endif]-->Glut2
- Fígado e Células b-Pancreáticas

<!--[if !supportLists]-->· <!--[endif]-->Glut3
- Cérebro e tecidos nervosos

<!--[if !supportLists]-->· <!--[endif]-->Glut4
- Músculo e tecido adiposo

<!--[if !supportLists]-->· <!--[endif]-->Glut5
- Intestino delgado

FÍGADO 

PAPEL CENTRAL
-&nbsp; Capta e metaboliza os nutrientes.

GLICOSE:
Fígado retém 60% da glicose que entra pelo sistema porta.&nbsp; Não influenciado pela insulina. 



<!--[if !supportLists]-->•&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<!--[endif]-->Síntese de
glicogênio

<!--[if !supportLists]-->•&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<!--[endif]-->Glicólise
aumentada – produzir acetil CoA como bloco construtor

<!--[if !supportLists]-->•&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<!--[endif]-->Gliconeogênese
diminuída 

LÍPIDES: 

<!--[if !supportLists]-->•&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<!--[endif]-->Aumenta a
síntese de ácidos graxos, TG, colesterol, etc. 

PROTEÍNAS: 

<!--[if !supportLists]-->•&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<!--[endif]-->Degradação aumentada de Aa (há mais Aa que o fígado pode utilizar). Fígado libera Aa para tecidos
periféricos ou degrada (desaminação e formação de intermediários de Krebs para
fonte de energia)

<!--[if !supportLists]-->•&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
<!--[endif]-->Síntese protéica: O corpo não
armazena proteínas e assim a síntese protéica é baixa, para repor eventuais
proteínas degradadas
no estado absortivo prévio. 



TECIDO MUSCULAR

Captação aumentada de glicose para
utilização&nbsp; 

Síntese aumentada de glicogênio:
depletado como resultado da atividade muscular 

Síntese aumentada protéica: Síntese para
repor a proteína perdida desde a refeição anterior



CÉREBRO

Consome 20% do oxigênio corporal em
repouso. 

Prioridade de energia. Usa
exclusivamente glicose como fonte de energia. Não contém depósito de glicogênio
– Dependente da glicose do sangue. 

Ácidos graxos não atravessam
eficientemente barreira hemato-encefálica = TG não contribui como fonte de
energia e nem deposita neste órgão.



Jejum



Glucagon, adrenalina e cortisol -&gt;
mobilização da reserva&nbsp; energética 

Fígado -&gt; Glicogenólise,
neoglicogênese -&gt; glicose

Lipólise -&gt; tecido adiposo -&gt;
triglicerídeos -&gt; glicerol 

Lipólise -&gt; tecido adiposo -&gt; triglicerídeos
-&gt; ácidos graxos (AGL)

GLICONEOGÊNESE



<!--[if !supportLists]-->v <!--[endif]-->Síntese
de glicose a partir de diferentes substratos

<!--[if !supportLists]-->v <!--[endif]-->&nbsp;Rota essencialmente de JEJUM

<!--[if !supportLists]-->v <!--[endif]-->&nbsp;90% Hepática, 10% renal

<!--[if !supportLists]-->v <!--[endif]-->&nbsp;Produz Glicose para ser lançada a circulação 

<!--[if !supportLists]-->v <!--[endif]-->&nbsp;Mantém a glicemia em níveis mínimos normais

<!--[if !supportLists]-->v <!--[endif]-->&nbsp;IMPORTANTE:


<!--[if !supportLists]-->o&nbsp;
<!--[endif]-->Qualquer substrato da via gliconeogênica
deve ter no mínimo 3 Carbonos, logo o Acetil CoA (2C) NÃO é substrato para esta
via.

<!--[if !supportLists]-->v <!--[endif]-->&nbsp;Substratos utilizados:

<!--[if !supportLists]-->o&nbsp;
<!--[endif]-->- Lactato

<!--[if !supportLists]-->§ <!--[endif]-->&nbsp;Aas
gliconeogênicos

<!--[if !supportLists]-->§ <!--[endif]-->&nbsp;Glicerol



Fase catabólica




 
 
  
  
  
  
  
  
  
  
  
  
  
  
 
 
 
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Estado inicial do jejum

<!--[if !supportLists]-->Ø <!--[endif]-->Após
1 a 2 dias – a concentração do glicogênio do fígado cai a 10% do valor inicial
e assim permanece o resto do período de jejum

<!--[if !supportLists]-->Ø <!--[endif]-->O
glicogênio do músculo também sofre decréscimo

<!--[if !supportLists]-->Ø <!--[endif]-->A
glicemia permanece em 80 mg/dl por cerca de 4 semanas ou pouco mais

<!--[if !supportLists]-->Ø <!--[endif]-->A
degradação de glicogênio permite a manutenção da glicemia no início do jejum

<!--[if !supportLists]-->Ø <!--[endif]-->A
oxidação de triacilgliceróis é acompanhada por aumento de corpos cetônicos no
sangue



<!--[if !supportLists]-->v <!--[endif]-->Corpos
Cetônicos são compostos derivados do Acetil-CoA



Em situações especiais, como jejum
prolongado e diabetes, Corpos Cetônicos
são produzidos porque há um :

<!--[if !supportLists]-->Ø <!--[endif]-->&nbsp;Excesso de degradação de triacilgliceróis,

<!--[if !supportLists]-->Ø&nbsp; <!--[endif]-->&nbsp;Falta de intermediários do Ciclo de Krebs para
oxidar todo o Acetil-CoA formado

<!--[if !supportLists]-->Ø <!--[endif]-->&nbsp;Nota: O Ciclo de Krebs funciona pouco, pois há
falta de glicose



O cérebro precisa de glicose (14 g/dia)
por isso as proteínas começam a ser degradadas mesmo quando a reserva de
gordura ainda não foi esgotada.



<!--[if !supportLists]-->Ø <!--[endif]-->A
glicose não pode ser sintetizada a partir de ácidos graxos (Acetil-CoA) ou
corpos cetônicos

<!--[if !supportLists]-->Ø <!--[endif]-->&nbsp;Então deve ser sintetizada a partir de
aminoácidos glicogênicos

<!--[if !supportLists]-->Ø <!--[endif]-->Ao
final da 4a ou 6a semana de jejum, menos de 15 g de
proteína/dia são consumidos

<!--[if !supportLists]-->Ø <!--[endif]-->Nesta
altura, volta a ocorrer a degradação de gorduras

<!--[if !supportLists]-->Ø <!--[endif]-->&nbsp;Pois o cérebro passa a utilizar corpos
cetônicos para obter energia (principalmente &nbsp;b-hidroxibutirato).


<!--[if !supportLists]-->Ø <!--[endif]-->Não
há alteração da capacidade mental

<!--[if !supportLists]-->Ø <!--[endif]-->A
grande produção de corpos cetônicos leva a uma acidose, com significativa
redução do bicarbonato plasmático. 

<!--[if !supportLists]-->Ø <!--[endif]-->Após
terem se esgotado as reservas de gordura, o indivíduo volta a utilizar proteínas
para obter energia. 

<!--[if !supportLists]-->Ø <!--[endif]-->São
degradadas proteínas musculares (ex: coração) e o indivíduo chegaria a óbito.



Tempo de sobrevivência depende do depósito de TG +
Terminado as reservas de TG&nbsp; -&gt;
proteólise =&nbsp; Perda da função cardíaca,
hepática e renal = MORTE 



Reflexão



Pude observar como o nosso organismo é
bioquimicamente antes e depois de nos alimentarmos. E como o metabolismo do
nosso organismo é muito mais complexo do que imaginamos. Apesar de não entender
muito bem desse assunto pude tirar bastantes informações da aula.