Sindrome de Down
Autor: Enf. Jessica Borges | Publicado: 2012-10-09T07:02:00-07:00

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; A síndrome de Down é um
distúrbio genético que ocorre ao acaso durante a divisão celular do embrião.
Esse distúrbio ocorre, em média, em 1 a c

ada 800 nascimentos e tem maiores chances de
ocorrer em mães que engravidam quando mais velhas. É uma síndrome que atinge
todas as etnias.

Em uma célula normal da espécie humana existem 46
cromossomos divididos em 23 pares. A pessoa que tem síndrome de Down possui 47
cromossomos, sendo que o cromossomo extra é ligado ao par 21. Esse distúrbio
genético pode se apresentar das seguintes formas:

Trissomia 21 padrão

Cariótipo 47XX ou 47XY (+21). O indivíduo
apresenta 47 cromossomos em todas as suas células, tendo no par 21 três
cromossomos. Ocorre aproximadamente em 95% dos casos.

Trissomia por translocação

Cariótipo 46XX (t14;21) ou 46XY (t14; 21). O
indivíduo apresenta 46 cromossomos e o cromossomo 21 extra se adere a outro
par, geralmente o 14. Ocorre aproximadamente em 3% dos casos.

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<![endif]--><!--[if gte mso 10]>

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<![endif]-->


Mosaicismo: é a causa de 1% a 2% dos casos apontados e pode ocorrer
de duas formas. Na primeira, uma não-disjunção em uma divisão celular durante
as primeiras divisões do zigoto (deixando essa célula com uma trissomia 21) dá
origem a mais células iguais a si nas divisões seguintes, e as células
restantes permanecem iguais. Na segunda, um zigoto (ou embrião) com Síndrome de
Down sofre igual mutação, revertendo as células para um estado de euploidia, ou
seja, correto número de cromossomos, que não possuem trissomia 21.



&nbsp;



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<![endif]-->

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<![endif]--><!--[if gte mso 10]>

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<![endif]-->http://www.brasilescola.com/doencas/sindrome-de-down.htm

<!--[if gte mso 9]>
 
  
  
 
<![endif]-->

<!--[if gte mso 9]>
 
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<![endif]--><!--[if gte mso 9]>
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<![endif]--><!--[if gte mso 10]>

 /* Style Definitions */
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 mso-fareast-language:EN-US;}

<![endif]-->http://www.sindromededown.info/causas-geneticas.php