Fenitoína em pacientes com hipoalbuminemia
Autor: Helga Bischoff | Publicado: 2012-04-25T15:32:00-07:00


&nbsp;&nbsp; A fenitoína tem grande afinidade por proteínas, principalmente pela albumina. Com isso, pacientes que estão com hipoalbuminemia terão uma fração de fenitoína livre maior. Mas no que isso implica? Ao realizarmos a dosagem sérica de fenitoína, o resultado pode aparentemente estar dentro dos limites desejados, porém, não podemos deixar de levar em consideração a hipoalbuminemia. A fórmula de Sheiner- Tozer permite que se tenha uma concentração sérica corrigida de fenitoína para pacientes com hipoalbuminemia.



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C corrigida fenitoína = &nbsp; &nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp; C sérica de fenitoína&nbsp;&nbsp;&nbsp;&nbsp; 

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; &nbsp;&nbsp; 0,2 x
C sérica albumina + 0,1



Onde: &nbsp;C =
Concentração



&nbsp; A fenitoína é um medicamento antiepiléptico que em doses tóxicas pode ser letal, portanto é aconselhado um acompanhamento pelo farmacêutico clínico da dosagem sérica da mesma bem como da albumina e,quando necessário,&nbsp; fazer as sugestões de ajuste de dose junto à equipe médica.