Novo Tratamento do Alzheimer  Aponta Restauração  da Memória
Autor: Aleh | Publicado: 2015-03-24T03:13:00-03:00

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Pesquisadores australianos criaram uma tecnologia de ultra-som não-invasiva
que limpa o cérebro das placas amilóides neurotóxicos responsáveis pela perda
de memória e pelo declínio da função cognitiva em pacientes com
Alzheimer."





Matéria publicada na Revista Ciência Online
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&nbsp;Se uma pessoa tem a doença de Alzheimer, isso é geralmente o
resultado de uma acumulação de dois tipos de lesões - placas amilóides e
emaranhados neurofibrilares. As placas amilóides ficam entre os neurônios e
criam aglomerados densos de moléculas de beta-amilóide.

Os emaranhados neurofibrilares são encontrados no interior dos neurónios
do cérebro, e são causados por proteínas Tau defeituosas que se aglomeram numa
massa espessa e insolúvel. Isso faz com que pequenos filamentos chamados microtúbulos
fiquem torcidos, perturbando o transporte de materiais essenciais, como
nutrientes e organelas.

Como não temos qualquer tipo de vacina ou medida preventiva para a
doença de Alzheimer - uma doença que afeta 50 milhões de pessoas em todo o
mundo - tem havido uma corrida para descobrir a melhor forma de tratá-la,
começando com a forma de limpar as proteínas beta-amilóide e Tau defeituosas do
cérebro dos pacientes.



Agora, uma equipa do Instituto do Cérebro de Queensland, da Universidade
de Queensland, desenvolveu uma solução bastante promissora. Publicando na Science
Translational Medicine, a equipa descreve a técnica como a utilização de um
determinado tipo de ultra-som chamado de ultra-som de foco terapêutico, que
envia feixes feixes de ondas sonoras para o tecido cerebral de forma não
invasiva.



Por oscilarem de forma super-rápida, estas ondas sonoras são capazes de
abrir suavemente a barreira hemato-encefálica, que é uma camada que protege o
cérebro contra bactérias, e estimular as células microgliais do cérebro a
moverem-se. As células da microglila são basicamente resíduos de remoção de
células, sendo capazes de limpar os aglomerados de beta-amilóide tóxicos.

Os pesquisadores relataram um restauro total das memórias em 75 por
cento dos ratos que serviram de cobaias para os testes, havendo zero danos ao
tecido cerebral circundante. Eles descobriram que os ratos tratados
apresentavam melhor desempenho em três tarefas de memória - um labirinto, um
teste para levá-los a reconhecer novos objetos e um para levá-los a relembrar
lugares que deviam evitar.





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fique antenado com as novidades nos campos da Filosofia , Ciências e Artes :



https://www.facebook.com/pages/Forum-Atenas/195099823853913?fref=ts




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