9º Fichamento - A Predisposição Genética
Autor: Lorena Moura | Publicado: 2011-06-03T07:40:00-07:00

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A Predisposição Genética para o Desenvolvimento daMicroangiopatia no DM1
“A prevenção das complicações crônicas é uma questãochaveno manejo do diabetes melito (DM) por causada morbimortalidade a elas associadas. O Diabetes Controland Complications Trial (DCCT) (1) demonstrouque o controle intensivo da glicemia reduz a incidênciade complicações microvasculares em diabéticos melitotipo 1 (DM1), reforçando a hiperglicemia como o fatorde risco mais importante para o aparecimento dessascomplicações. Sabe-se, entretanto, que outros fatores derisco modificáveis, como a hipertensão arterial sistêmica(HAS), a dislipidemia e o tabagismo, participam do desenvolvimentoda microangiopatia diabética.”“Tendo em vista as dificuldades de aderência ao tratamentointensivo, a identificação de marcadores genéticospara o desenvolvimento das complicações pode ajudar adefinir que pacientes necessitam de um controle glicêmicomais (ou menos) rigoroso (3), além de permitir melhorcompreensão da patogênese das complicações, oque pode possibilitar o desenvolvimento de novas terapiasdirecionadas para prevenção e tratamento.”“Em conclusão, para melhor compreensão dos fatoresgenéticos associados ao desenvolvimento das complicaçõesmicrovasculares são necessários estudos comgrande número de pacientes incluídos, que estes apresentemfenótipos bem caracterizados e que formemgrupos bem estratificados. Com a evolução da tecnologiae a popularização de métodos capazes de rastrearmilhares de polimorfismos simultaneamente, os estudosde associação ganharão maior importância e poderãopermitir que se conheça mais profundamente apatogênese das complicações e que se desenvolvam medidaspreventivas específicas a serem adotadas no tratamentodaqueles pacientes predispostos.”FONTE: //www.fag.edu.br/professores/fernando/Fisiologia%204%B0%20P%20Integral%20e%20Noturno/artigo%202.pdf