Doença de Parkinson
Autor: Lígia Martins | Publicado: 2011-10-05T17:53:00-07:00

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Os sintomas mais claros da doença de Parkinson são o tremor em repouso, a rigidez muscular e a dificuldade para realizar movimentos voluntários. É causada por uma apoptose descontrolada dos neurônios.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; O principal medicamento utilizado no tratamento é a levodopa, que pode ser dada em conjunto com um inibidor periférico da dopadescarboxilase, (carbidopa, benserazida), ou com a selegina, que é um inibidor seletivo da MAO-B. Os efeitos adversos da levodopa são náuseas, anorexia, hipotensão postural, delírios, alucinações, confusão, desorientação, insônia e pesadelos tendem a desaparecer com a continuidade do tratamento, discinesia (movimentos involuntários de contorção), hipocinesia e rigidez.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Outra opção são os agonistas do receptor de dopamina. A bromocriptina causa náuseas, vômitos e fibrose peritonial. Enquanto a lisurida, a pergolida, o ropinirol, a carbegolina e o pramipexol, geram confusão e delírios ocasionais, e distúrbios do sono.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; A amantadina também aumenta a liberação da dopamina, mas é menos efetiva que a levodopa.