POTENCIAL ONCOGÊNICO DOS RETROVÍRUS
Autor: Izabella Danezi Felin | Publicado: 2016-07-08T09:59:00-03:00

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POTENCIAL
ONCOGÊNICO DOS RETROVÍRUS
Os retrovírus são vírus que têm o ácido
ribonucleico (RNA) como material genético, portanto, suas enzimas não são
capazes de corrigir erros durante a replicação viral, logo, ocorrem mais
mutações genéticas nos vírus RNA. Os retrovírus estão relacionados a várias
neoplasias em animais, pois apresentam oncogenes em seu genoma ou alta
capacidade de integração ao genoma celular. Os oncogenes provocam mutações no DNA
da célula infectada. Apesar de estarem comprovadamente relacionados a neoplasias
em animais, apenas um vírus a RNA é aceito como causador de tumores em humanos,
o HTLV-1. Este vírus está associado a um tipo de leucemia de células T em
adultos. Ele apresenta as seguintes regiões típicas dos retrovírus e essenciais
para a integração à célula do hospedeiro, são as gag, pol e env que
codificam proteínas para capsídeo, enzima transcriptase e proteínas do envelope
viral, respectivamente. Além disso, possui regiões adicionais px, codificantes de proteínas
regulatórias como Tax e Rex. A proteína Tax induz uma resposta imune de células T CD8 capaz de incapacitar
o vírus, porém dependendo de propriedades do hospedeiro, pode interagir com
fatores de transcrição celulares e interferir na replicação e transformação
celular, através do aumento da expressão de citocinas e receptores relacionados
ao crescimento e proliferação celular, além de ser capaz de inibir diferentes
proteínas responsáveis pela supressão tumoral, suprimindo o reparo e a apoptose,
com consequente imortalização celular. Testes em camundongos comprovam que essa
proteína é capaz de imortalizar células T primárias, transformar fibroblastos e
induzir tumores em camundongos transgênicos que apresentam Tax. A proteína Rex atua
em eventos após a tradução através na regulação da expressão gênica, o que a
torna essencial para a multiplicação, infecção e disseminação viral. A
facilidade com que os RNA vírus conseguem se integrar ao genoma e codificar
diferentes proteínas capazes de regular a expressão dos genes sugere que outros
tipos de tumores humanos possam estar relacionados aos retrovírus. Encontra-se
na literatura hipóteses de que ele possa estar relacionado a algumas leucemias
e ao câncer de mama humanos, pois foram encontrados expressões do vírus em tecidos
tumorais mamários, entretanto os estudos são controversos. A importância do
estudo do potencial oncogênico dos retrovírus é justificada pelas diversas
possibilidades de relacioná-los, através de estudos de bases moleculares genéticas,
a afecções neoplásicas em humanos.