Question: Please answer this: Given the background: Currently, millions of individuals with high cholesterol take a similar type of drug, known as a statin. The drug, an inhibitor of HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase), the rate limiting enzyme in cholesterol biosynthesis, decreases blood levels of cholesterol by induce the expression of low density lipoprotein (LDL) receptors in the liver. The increased levels of the LDL-receptors stimulate the catabolism of plasma LDL, removing cholesterol from plasma, which is an important determinant of atherosclerosis. You may know of people who take a statin to help with their cholesterol levels. However, these drugs probably work slightly differently in many of those people. In some, it lowers their cholesterol significantly; in others it may lower it only moderately; and in some, it may have no significant effect at all. (Luckily for those individuals, there are multiple versions of the statins, so different drugs can be tested to find the proper combination for that individual.) Why the difference? Because of the genetic background of all people; the different single nucleotide polymorphisms that make us all different. Pharmacogenomics, a combination of pharmacology and genomics (the study of the genome) that refers to the study of the relationship between pharmaceuticals and genetics, may explain and simplify this problem.  and the situation: Uncle Tom and uncle Sam both have high cholesterol. Uncle Tom is on statin drugs and uncle Sam is not.  Answer the following question: Which uncle takes an inhibitor of the rate limiting enzyme that decreases blood levels of cholesterol?
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Answer: Tom


Please answer this: Given the background: Blood vessels help regulate body processes by either constricting (becoming narrower) or dilating (becoming wider). These actions occur in response to signals from the autonomic nervous system or the endocrine system. Constriction occurs when the muscular walls of blood vessels contract. This reduces the amount of blood that can flow through the vessels (see Figure below ). Dilation occurs when the walls relax. This increases blood flows through the vessels.  and the situation: Greg is a physician working for the city hospital. Today he is seeing two patients, patient A and patient B. He noticed that patient A's blood vessels are constricted, but blood vessels of patient B are dilated. He needs to prescribe medicine according to his observation.  Answer the following question: In which patient the muscular walls of the blood vessels would not contract, patient A or patient B?
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Answer: patient B


Please answer this: Given the background: Acromyrmex heyeri is a species of leaf-cutter ant, a New World ant of the subfamily Myrmicinae of the genus Acromyrmex. Acromyrmex heyeri workers construct the colonies nest by thatching together cut grass. At temperatures ranging from 20–30 °C, workers created more openings in the nest thatch as the internal nest temperature goes up as a method of temperature regulation for the colony. The workers will close openings in the nest thatch as the air humidity surrounding the nest decreases to reduce water loss for the colony.  and the situation: In the ant world a war has been waged. Two rival groups of Acromyrmex heyeri ants, group A and group B, are battling each other to gain territory. The goal is to attack the rival group when they have more openings in their nest thatch. In battle day one group A territory had 5 °C temperature. In battle day two group A territory had 22 °C temperature. In battle day three group A territory had low air humidity. In battle day four group A territory had high air humidity.  Answer the following question: In battle day one would group A have less openings or more openings in their nest thatch?
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Answer:
Answer: less openings