Question: Q: TEXT: By. Deni Kirkova. PUBLISHED:. 09:31 EST, 2 April 2013. |. UPDATED:. 09:31 EST, 2 April 2013. It was once a skill we all took for granted, but now it appears fewer than one in ten young people can change a plug. Only eight per cent of 18 to 25-year-olds now say they could confidently rewire a plug without help or instruction, according to new research. Moreover, only five per cent of young people would be confident unblocking a sink, while only six per cent said they would be happy to bleed a radiator. Where does this wire go? Just 8 per cent of young people in the UK are confident enough to rewire a plug. An inept 17 per cent said they wouldn't even be confident hanging a picture, with only 12 per cent vowing themselves capable of using a power drill. Just four per cent said they could put up wallpaper, and more than a fifth (21 per cent), doubted their own ability to assemble flat-pack furniture. A spokesperson from NetVoucherCodes.co.uk, who conducted the survey, said: 'In the past electrical goods came without a plug attached so it was necessary to know how to wire one. 'Now though our toasters and TVs come with the plugs already fitted so it seems wiring one is becoming something of a lost skill. 'The Easter weekend is traditionally a time to tackle DIY tasks but it seems young people are content to sit back and let Dad take the strain. Let’s hope future generations don’t lose the skills their fathers and grandfathers took for granted.' Left a bit...: An inept 17 per cenr said they wouldn't even be confident in hanging up a picture up. One man said: 'I still have to ring up my Dad for DIY help. I can just about manage to put a bookshelf together' (picture posed by model) One young man who took part in the survey said: 'I still have to ring up my Dad for DIY help. I can just about manage to put a bookshelf together, but for anything more complicated I need his help. 'It’s not the end of the world that I’m unable to do certain DIY tasks, I mean, if it weren’t for people like me there’d be no work for plumbers and electricians.' A woman who took part commented: 'It’s very unattractive in a man not to be able to do simple jobs round the house. Although I have to admit if there is a DIY task I can’t do my first response is to reach for the internet.' Pretty as a picture: While only 12 per cent can use a power drill, women say they find men not able to do simple DIY unattractive.
A: Highlights: Over 90% of 18-25-year-olds cannot change a plug with confidence. One fifth can't hang a picture, and only 5% would unblock a sink. Women say it's 'very unattractive for a man not to be able to do simple jobs' Male participants say they ring parents for DIY help, women look online.

Q: TEXT: Scientists have identified what they believe is the key to wrinkle free skin, raising hopes for creams and treatments that could defy aging. In a 20-week tanning experiment, they found that mice who lacked the enzyme Granzyme-B had aged significantly less than than those who had it. The researchers found that they also had noticeably smoother skin and their collagen was more intact. The secret to wrinkle-free skin may lie in blocking an enzyme called Granzyme B, scientists believe. Incredibly the discovery was made by accident as the researchers were looking into the role of Granzyme-B in atherosclerosis and heart attacks. During their experiments they happened to notice the difference in the quality of the skin on the different groups of mice. Lead researcher David Granville of the University of British Columbia said: ‘This is one of those moments that we live for in science. ‘We were interested in the effects of aging on blood vessels; we had no idea (the absence of this enzyme) would have any effect on their skin.’ Professor Granville added that his team was developing drugs that can block Granzyme B - and hoped to make them commercially available soon. He said: ‘We have generated natural and synthetic inhibitors of this enzyme and one can easily see the application for this after excessive sun exposure...or in other cosmetics as well. ‘That’s obviously the first thing that comes to mind’. The research team created a miniature tanning salon for the mice in the experiment and each mouse was put on a carousel that turned under UV lamps. The animals were exposed to the light three times a week for three to four minutes each session, which was enough to make them red but not to burn. By week 20, it was clear that the mice who had been engineered to lack Granzyme B had pristine skin - but the control group had wrinkles. Professor Granville said: ‘About 80 to 90 per cent of visible skin aging is caused by sunlight. ‘We found that by knocking out (Granzyme B) we could markedly protect against the loss of collagen and it prevented wrinkling in these mice.’ Scientists hope creams and treatments that could defy aging may come from the discovery. Granzyme B appears to work by interfering with the the integrity of collagen and dismantling the ‘cellular scaffolding’ that binds its cells together. This results in structural weakness which we see on the surface as wrinkles. Exposure to sunlight appears to increase the level of Granzyme B, thus accelerating its harmful effect on the skin. Professor Granville said that many anti-aging cosmetics include collagen which consumers apply to the skin even though it does very little. He said: ‘By adding collagen without putting out the fire, you are just adding wood to the fire. ‘This offers an actual realistic solution, where you can inhibit the enzyme that is leading to the breakdown of collagen.’ Professor Granville’s Canadian company, viDa Therapeutics, is currently working on a lotion that will stop sores and burns caused by too much sun. And whilst the experiment worked in mice who were bred to have no Granzyme B at all, in humans things are more complicated as the enzyme it is part of the immune system and removing it may have unintended consequences.
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Answer: Highlights: Mice who lacked the enzyme Granzyme-B aged significantly less. Also had noticeably smoother skin and their collagen was more intact. Discovery was made by accident as the researchers were looking into the role of Granzyme-B in hardening of the arteries and heart attacks. Scientists hope treatments that could defy aging may come from discovery.