syedzayyan/paper_mill_benchmark huggingface dataset:
Computational analysis the relationships of energy and mechanical properties with sensitivity for FOX-7 based PBXs via MD simulation.

Molecular dynamics (md) simulations have been applied to investigate 1, 1-diamino-2, 2-dinitroethene (fox-7) crystal and fox-7 (011)-based polymer-bonded explosives (pbxs) with four typical polymers, polyethylene glycol (peg), fluorine-polymer (f2603), ethylene-vinyl acetate copolymer (eva) and ester urethane (estane5703) under compass force field.Binding energy (ebind), cohesive energy density (ced), initiation bond length distribution, rdg analysis and isotropic mechanical properties of fox-7 and its pbxs at different temperatures were reported for the first time, and the relationship between them and sensitivity.Using quantum chemistry, fox-7 was optimized with the four polymers at the b3lyp/6-311++g(d,p) level, and the structure and rdg of the optimized composite system were analysed.The results indicated that the binding energy presented irregular changes with the increase in temperature.The order of binding ability of different binders to the fox-7 (011) crystal surface is peg > estane5703 > eva > f2603.When the temperature increases, the maximum bond length (lmax) of the induced bond increases and the ced decreases.This result is achieved in agreement with the known experimental fact that the sensitivity of explosives increases with temperature, and they can be used as the criterion to predict the sensitivity of explosives.The descending order of lmaxis fox-7 > f2603> estane5703≈eva > peg.The intermolecular interactions between fox-7 and the four polymers were mainly weak hydrogen bonding and van der waals interactions, and these interactions helped to reduce the bond length of c-no2, leading to a decrease in the sensitivity of fox-7.The addition of polymers can effectively improve the mechanical properties of explosives.Among the four polymers, eva has the best effect on improving the mechanical properties of fox-7 (011).At the same temperature, the modulus can be used to predict the sensitivity of high-energy materials.Cauchy pressure can predict the sensitivity of non-brittle energetic materials.The nature of the interaction between fox-7 and the four polymers is hydrogen bonding and van der waals force, of which hydrogen bonding is the main one.These studies are meaningful for the formulation design and sensitivity prediction of fox-7 and its pbxs.

Journal: Royal Society open science (2021)
Publication types: Journal Article
Antecedents and outcomes of job embeddedness among nurses.

Embedding nurses in their jobs is associated with many positive results because they have to deal with varying patient needs and sometimes make close relationships with them.Having mentioned that, we have limited knowledge of antecedents and possible outcomes of job embeddedness.Accordingly, this study aimed to explore the mediating role of job embeddedness (je) among this group in the relationship between team-member exchange (tmx), empowering leadership (el), and perceived organizational support (pos) with innovative work behavior (iwb).Data were gathered from a group of 800 nurses, who were working in fourteen different public hospitals in the northeast of iran.Of 800 distributed questionnaires, 723 questionnaires were completely filled.Different statistical analysis methods, such as confirmatory factor analysis (cfa), pearson correlation coefficient, and structural equation modeling (sem), were used for data analysis.The results indicate the positive influence of tmx and pos on iwb through the mediating role of je in this group.It is worth noting that the je-mediated effect of el on iwb was not significant.

Journal: The Journal of social psychology (2022)
Publication types: Journal Article
Beyond probiotic legend: ESSAP gut microbiota health score to delineate SARS-COV-2 infection severity.

Covid-19 pandemic continues to be a global health crisis.The gut microbiome critically affects the immune system, and some respiratory infections are associated with changes in the gut microbiome; here, we evaluated the role of nutritional and lifestyle habits that modulate gut microbiota on covid-19 outcomes in a longitudinal cohort study that included 200 patients infected with covid-19.Of these, 122 cases were mild and seventy-eight were moderate, according to who classification.After detailed explanation by a consultant in clinical nutrition, participants responded to a written questionnaire on daily sugar, prebiotic intake in food, sleeping hours, exercise duration and antibiotic prescription, during the past 1 year before infection.Daily consumption of prebiotic-containing foods, less sugar, regular exercise, adequate sleep and fewer antibiotic prescriptions led to a milder disease and rapid virus clearance.Additionally, data on these factors were compiled into a single score, the essap score (exercise, sugar consumption, sleeping hours, antibiotics taken, and prebiotics consumption; 0-11 points), median essap score was 5 for both mild and moderate cases; however, the range was 4-8 in mild cases, but 1-6 in moderate (p = 0·001, or: 4·2, 95 % ci 1·9, 9·1); our results showed a negative correlation between regular consumption of yogurt containing probiotics and disease severity (p = 0·007, or: 1·6, 95 % ci 1·1, 2·1).Mild covid-19 disease was associated with 10-20 min of daily exercise (p = 0·016), sleeping at least 8 h daily, prescribed antibiotics less than 5 times per year (p = 0·077) and ate plenty of prebiotic-containing food.

Journal: The British journal of nutrition (2022)
Publication types: Journal Article
Endoscopic management of a spontaneous rectus sheath hematoma causing bladder perforation.

Rarely pelvic hemorrhage events can lead to bladder perforation.We present a 48-year-old female who developed a spontaneous rectal sheath hematoma which perforated her bladder.Her case was monitored with serial mri imaging and managed with two endoscopic clot resections which demonstrated new epithelialization of the bladder wall across the hematoma point of entry.We conclude that the bladder has an impressive potential to heal and select cases of symptomatic invasive bladder hematomas may be monitored with serial imaging and managed endoscopically.

Journal: Urology case reports (2022)
Publication types: Case Reports;Journal Article
The Regulatory Mechanism of EpCAM N-Glycosylation-Mediated MAPK and PI3K/Akt Pathways on Epithelial-Mesenchymal Transition in Breast Cancer Cells.

It was to investigate the regulation of motigen-activated protein kinase (mapk) and phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt) pathways mediated by epithelial cell adhesion molecules (ep cam) n-glycosylation on epithelial-mesenchymal transition (emt) in breast cancer cells.Breast cancer cells mcf-7 and mda-mb-231 were taken in the control group; the blank vector plasmid transfection (blank plasmid group) and ep cam n-glycosylation mutant plasmid transfection (mutant-ep cam group) were analyzed.The ep cam in breast cancer cells was localized by immunofluorescence technique, the proliferation activity of cells in each group was detected by methyl thiazolyl tetrazolium (mtt) assay, and the clonality of cells was detected by plate cloning.And apoptosis-related proteins (caspase-3, bcl-2, and bax), emt-related molecular markers (e-cadherin, n-cadherin, and vimentin), as well as mapk and pi3k/akt pathway-related proteins (p38, pi3k, and akt) in cells were detected by western blotting (wb).Ep cam n-glycosylation mutations did not alter the expression localization of ep cam in breast cancer cells.Compared with the control group and the blank plasmid group, the cell proliferation activity and the number of colonies formed were decreased in the mutant-ep cam group (p<0.05).The protein expressions of caspase-3, bax, and e-cadherin were up-regulated significantly, and the expressions of bcl-2, n-cadherin, vimentin, p-p38, p-pi3k, and p-akt were greatly down-regulated (p<0.05).Ep cam n-glycosylation could regulate the emt in breast cancer cells through mapk and pi3k/akt pathways.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) (2022)
Publication types: Journal Article
Adolescents at risk of eating disorders: The mediating role of emotional distress in the relationship between differentiation of self and eating disorders.

Introduction adolescents may feel dissatisfied with their bodies, which may lead to a risk of eating disorders (eds) due to several factors, with emotional distress being one of the most important.Evidence suggests that family might be one of the most significant factors that may increase or decrease emotional distress.An important family pattern found to contribute to mental and physical health is the differentiation of self (do s).The primary purpose of the current study was to map the complex relationships between do s, emotional distress, and eds among adolescents.We hypothesized that emotional distress would mediate the relationship between do s and the risk of eds among adolescents.Moreover, based on findings indicating a higher risk of eds among females, we expected sex differences in the research indices and the mediation model.Methods the sample included 194 non-clinical adolescents (mean age 15.15; mean bmi 21.66).Preliminary analyses examined differences between males and females usingt-tests.In addition, pearson correlations were run to assess the association between background variables and the study metrics among males and females.To examine the mediation effect, we ran sem.Results due to a sex moderation effect, two mediation models were run (sem), one for females and one for males.Results indicated that emotional distress partially mediated the relationships between do s and the risk of eds.In addition, sex differences were found in the mediated indices, showing that among female adolescents, perfectionism is the only dimension of eds that was associated with do s through the mediation of emotional distress.While the relationship between emotional distress and the risk of eds is well documented.Conclusions it is concluded that high do s may reduce emotional distress, which may, in turn, decrease the risk of eds.In addition, the results enable an in-depth understanding of specific risk factors of eds that characterize each sex.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article
Systematic review and meta-analysis of single injection fascia iliaca blocks in the peri-operative management of patients with hip fractures.

Introduction the aim of the study was to determine the analgesic efficacy and safety profile of single injection fascia iliaca compartment block (ficb) performed peri-operatively for isolated hip fractures.Evidence acquisition medline, embase, cochrane and cinahl were searched from inception to february 2018.Inclusion criteria were: english language, adult patients (>18 years old), isolated traumatic hip fracture treated with single injection ficb peri-operatively.Data were extracted into a pre-piloted form that utilized the prisma-p 2015 checklist.Two investigators conducted reviews independently; any ambiguity was resolved by discussion.The quality of studies was assessed using the grade checklist and cochrane risk of bias tool.A random-effects model was applied.Outcomes reviewed were pain level at rest and movement, breakthrough analgesia and complications.Evidence synthesis out of 3757 citations, eight rcts were included involving 645 participants.Pain was significantly reduced during movements (smd=-1.82, 95% ci -2.26 to -1.38, p<0.00001) but not at rest (smd=-0.68, 95% ci -1.70 to 0.35, p=0.20).Ficb allowed less (breakthrough) supplemental analgesic (n.=57 vs.N.=73), however this did not reach statistical significance (p=0.19).Conclusions ficb is effective in controlling acute peri-operative pain in adult patients with traumatic hip fractures.The benefit is more evident during mobilization of the limb when compared to patients at rest.

Journal: Minerva anestesiologica (2019)
Publication types: Journal Article;Meta-Analysis;Systematic Review
Retinal detachment during COVID-19 era: a review of challenges and solutions.

Since the beginning of the coronavirus disease 2019 (covid-19) pandemic, there have been obstacles in the proper diagnosis and management of many diseases.We evaluated the changes in retinal detachment (rd) presentation and surgery during the covid-19 pandemic and propose solutions to minimize the detrimental effects of lockdown on rd diagnosis.Materials and methods pub med, embase, scopus, web of science, and google scholar were searched for relevant articles with the keywords "retinal detachment" and "coronavirus or covid-19 or sars or mers." results the covid-19 lockdown was associated a 53-66% reduction in rd presentation.The decrease in the rate of macula-on rd, the increase in the mean duration of symptoms, and the rise in the number of patients with proliferative vitreoretinopathy were all suggestive of a delayed presentation of rd.Moreover, a drop of 56-62% in rd repair surgeries was observed.However, the most frequently performed ophthalmic surgery changed from cataract surgery in april 2019 to rd repair in april 2020.Using phacovitrectomy instead of vitrectomy alone can reduce the number of operations in ophthalmology centers, decrease the use of personal protective equipment by 50%, and cut costs per patient by 17-20%.Also, developing a well-organized telemedicine system can decrease unnecessary visits and delayed presentations.Conclusion delay in rd presentation and surgery is associated with a poorer prognosis.Optimizing the guidelines of rd management and developing a well-organized telemedicine system can minimize the impact of lockdown on rd management.

Journal: Spektrum der Augenheilkunde : Zeitschrift der Osterreichischen Ophthalmologischen Gesellschaft, OOG (2022)
Publication types: Journal Article;Review
Experiences of eating difficulties in siblings of people with anorexia nervosa: a reflexive thematic analysis.

Siblings of people with anorexia nervosa (an) have been found to experience strong emotions, changing family roles and poorer wellbeing as a consequence of experiencing the effects of the illness on their sibling and family system.These factors, combined with genetic influences, may put siblings at an increased risk of developing eating disorder psychopathology in addition to other mental health issues.This research aims to explore the experiences of siblings of people with an who have had eating difficulties themselves and investigate issues that may be important to the development and prevention of eating difficulties in this population.Methods this qualitative study used a reflexive thematic analysis approach.Ten adults who had witnessed a sibling with an and experienced eating difficulties themselves participated in semi-structured interviews.Analysis participants' own eating difficulties were affected by the specific experience of witnessing a sibling with an through mealtimes becoming emotionally charged, an increased focus on body size and diet, and comparisons with their sibling.Difficult experiences, such as marital discord amongst parents were common, as was a difficulty in managing emotions.The onset of an within the family caused participants to take on caring responsibilities for their sibling and to hide their own difficulties for fear of adding additional burden to their parents.This reduced their perceived ability to access support and for some increased a desire to restrict as a coping mechanism for the stress they were experiencing.Systemic beliefs regarding the value of thinness were prevalent and influential.Protective factors, such as not wanting to become as unwell as a sibling with an and an understanding of the negative consequences of an, aided recovery.Conclusions eating difficulties in siblings of people with an may be influenced by competition for slimness, increased focus on diet and body size, and a need to manage difficult emotions.The disruption to social connections and a difficulty finding emotional support that may be experienced by people when a sibling develops an may further influence susceptibility to eating difficulties.Further research is needed into the best ways to support siblings of people with an.

Journal: Journal of eating disorders (2022)
Publication types: Journal Article
Reproducible Inter-Personal Brain Coupling Measurements in Hyperscanning Settings With functional Near Infra-Red Spectroscopy.

Despite a huge advancement in neuroimaging techniques and growing importance of inter-personal brain research, few studies assess the most appropriate computational methods to measure brain-brain coupling.Here, we focus on the signal processing methods to detect brain-coupling in dyads.From a public dataset of functional near infra-red spectroscopy signals (n=24 dyads), we derived a synthetic control condition by randomization, we investigated the effectiveness of four most used signal similarity metrics: cross correlation, mutual information, wavelet coherence and dynamic time warping.We also accounted for temporal variations between signals by allowing for misalignments up to a maximum lag.Starting from the observed effect sizes, computed in terms of cohen's d, the power analysis indicated that a high sample size ([formula: see text]) would be required to detect significant brain-coupling.We therefore discuss the need for specialized statistical approaches and propose bootstrap as an alternative method to avoid over-penalizing the results.In our settings, and based on bootstrap analyses, cross correlation and dynamic time warping outperform mutual information and wavelet coherence for all considered maximum lags, with reproducible results.These results highlight the need to set specific guidelines as the high degree of customization of the signal processing procedures prevents the comparability between studies, their reproducibility and, ultimately, undermines the possibility of extracting new knowledge.

Journal: Neuroinformatics (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Predicting rectal temperature and respiration rate responses in lactating dairy cows exposed to heat stress.

Milk production and time effects are considered related to heat stress but they have not yet been combined in predictive models.In two parts, this study aimed to develop new models to predict heat stress (rectal temperature and respiration rate) of lactating dairy cows by inputting predictors, including ambient temperature (ta), relative humidity (rh), wind speed (ws), milk yield (my), and time blocks.In the first part of the study, we built the quantitative foundation for the second part, including the regression relation between respiration rate and rectal temperature (to convert predicted respiration rate to predicted body temperature), as well as between rectal temperature and respiration rate when heat stress was triggered (to recognize whether herds were under stress).In the second part, we built models that combined the abovementioned predictors to predict respiration rate.In part i, data were obtained from 45 high-producing holstein cows within a tarange of 9.5 to 30.8°c.We found a very strong correlation between mean respiration rate (mrr) and mean rectal temperature (mrt), where mrt = 0.021 × mrr + 37.6 (r2= 0.925), suggesting that for each 4.8 breaths per minute (bpm) increase of mrr, mrt would be expected to increase by 0.1°c.Rectal temperature was determined to be 38.6°c when heat stress was triggered, which corresponded to a respiration rate of 48 bpm.In part ii, data were obtained in 3 stalls within a tarange of 6.9 to 33.3°c over 3 time blocks, all of which were the 90 min preceding milking (0630-0800, 1230-1400, and 1830-2000 h).We found a nonlinear response of mrr to ta, which could be linearized by the quadratic term of ta.The response of mrr was the highest in the 0630-0800 h block, followed by 1230-1400 h, and finally 1830-2000 h.We proposed a model combining 3 time blocks (r2= 0.836): mrr in 0630-0800 h was determined to 56.28 + (-3.40 + 0.11 × ta+ 0.02 × rh) × ta- 0.21 × rh - 2.82 × ws + 0.62 × my; mrr in 1230-1400 h and 1830-2000 h were 4.6 and 10.3 bpm lower than that in 0630-0800 h, respectively (reducing the intercept of the expression in 0630-0800 h).Compared with temperature-humidity index equations, the proposed model performed better at suppressing prediction error, and had better sensitivity and accuracy in recognizing whether heat stress was triggered.

Journal: Journal of dairy science (2020)
Publication types: Journal Article
Plaster cast treatment for distal forearm fractures in children: which index best predicts the loss of reduction?

Several radiological indices were introduced to evaluate cast adequacy for paediatric distal forearm fractures: cast, gap, padding, canterbury (reflecting the cast shape and the amount of padding) and three-point indices, and second metacarpal-radius angle (measuring cast ulnar-moulding).The aim of this study is to define which index is most reliable in assessing cast adequacy and predicting redisplacements.Hundred twenty-four consecutive patients (age 5-18) affected by distal both-bone forearm or radius fractures treated with casting were included.These indices and the displacement angles were calculated on the initial radiograph after reduction.Radiographs at 7 and 30 days were taken to assess if the loss of reduction occurred, and measure the displacement deltas (displacement angle at day 30 - displacement angle at day 0).Student's t-test, chi-square test and pearson's correlation were used for the statistical analysis.High padding (p = 0.034), canterbury (p = 0.002) and cast (p < 0.001) indices showed an association with redisplacements in distal forearm fractures.Both-bone forearm fractures have a higher risk of loss of reduction than radius fractures [odds ratio (or = 4.99, 95% confidence interval (ci) = 2.21-11.3, p < 0.001].A higher displacement delta in antero-posterior (pearson's r = 0.418, p = 0.037) and lateral (p = 0.045) views for both-bone fractures showed an association with a high gap index.Regarding radius fractures, a high cast index is associated with a higher displacement delta in antero-posterior (p = 0.035).The three-point index and the second metacarpal-radius angle did not show any association with the redisplacement risk.Cast oval moulding without excessive padding may prevent redisplacements in paediatric distal forearm fractures, while casts ulnar-moulding does not.

Journal: Journal of pediatric orthopedics. Part B (2020)
Publication types: Journal Article