syedzayyan/paper_mill_benchmark huggingface dataset:
Relationships Between Memory Impairments and Hippocampal Structure in Patients With Subcortical Ischemic Vascular Disease.

And purpose patients with subcortical ischemic vascular disease (sivd) suffer from memory disorders that are thought to be associated with the hippocampus.We aimed to explore changes in hippocampal subfields and the relationship between different hippocampal subfield volumes and different types of memory dysfunction in sivd patients.Methods a total of 77 sivd patients with cognitive impairment (sivd-ci,n= 39) or normal cognition (hc-sivd,n= 38) and 41 matched healthy controls (hcs) were included in this study.Memory function was measured in all subjects, and structural magnetic resonance imaging (mri) was performed.Then, the hippocampus was segmented and measured by free surfer 6.0 software.One-way anova was used to compare the volume of hippocampal subfields among the three groups while controlling for age, sex, education and intracranial volume (icv).Then,post hoctests were used to evaluate differences between each pair of groups.Finally, correlations between significantly different hippocampal subfield volumes and memory scores were tested in sivd patients.Results almost all hippocampal subfields were significantly different among the three groups except for the bilateral hippocampal fissure (p= 0.366,p= 0.086, respectively.) and left parasubiculum (p= 0.166).Furthermore, the sivd-ci patients showed smaller volumes in the right subiculum (p< 0.001), ca1 (p= 0.002), presubiculum (p= 0.002) and molecular layer of the hippocampus (p= 0.017) than the hc-sivd patients.In addition, right subiculum volumes were positively related to rey's auditory verbal learning test (ravlt) word recognition (r= 0.230,p= 0.050), reverse digit span test (r-dst) (r= 0.326,p= 0.005) and rey-osterrieth complex figure test (rocf) immediate recall (r= 0.247,p= 0.035) scores, right ca1 volumes were positively correlated with ravlt word recognition (r= 0.261,p= 0.026), and right presubiculum volumes showed positive relationships with r-dst (r= 0.254,p= 0.030) and rocf immediate recall (r= 0.242,p= 0.039) scores.Conclusion sivd might lead to general reductions in volume in multiple hippocampal subfields.However, sivd-ci patients showed atrophy in specific subfields, which might be associated with memory deficits.

Journal: Frontiers in aging neuroscience (2022)
Publication types: Journal Article
Ten years of China's new healthcare reform: a longitudinal study on changes in health resources.

China launched a new round of healthcare-system reform in 2009 and proposed the goal of equal and guaranteed essential medical and health services for all by 2020.We aimed to investigate the changes in china's health resources over the past ten years after the healthcare reform.Methods data were collected from the china statistical yearbook and china health statistics yearbook from 2009 to 2018.Four categories and ten indicators of health resources were analyzed.A descriptive analysis was used to present the overall condition.The health resource density index was applied to showcase health-resource distribution in demographic and geographic dimensions.The global and local moran's i were used to assess the spatial autocorrelation of health resources.Concentration index (ci) was used to quantify the equity of health-resource distribution.A geo-detector model and geographic weighted regression (gwr) were applied to assess the association between gross domestic product (gdp) per capita and health resources.Results health resources have increased over the past ten years.The global and local moran's i suggested spatial aggregation in the distribution of health resources.Hospital beds were concentrated in wealthier areas, but this inequity decreased yearly (from ci=0.0587 in 2009 to ci=0.0021 in 2018).Primary medical and health institutions (pmhi) and their beds were concentrated in poorer areas (ci remained negative).Healthcare employees were concentrated in wealthier areas (ci remained positive).In 2017, the q-statistics indicated that the explanatory power of gdp per capita to beds, health personnel, and health expenditure was 40.7%, 50.3%, and 42.5%, respectively.The coefficients of gwr remained positive with statistical significance, indicating the positive association between gdp per capita and health resources.Conclusions from 2009 to 2018, the total amount of health resources in china has increased substantially.Spatial aggregation existed in the health-resources distribution.Health resources tended to be concentrated in wealthier areas.When allocating health resources, the governments should take economic factors into account.

Journal: BMC public health (2021)
Publication types: Journal Article
Polyploidy and Myc Proto-Oncogenes Promote Stress Adaptation via Epigenetic Plasticity and Gene Regulatory Network Rewiring.

Polyploid cells demonstrate biological plasticity and stress adaptation in evolution; development; and pathologies, including cardiovascular diseases, neurodegeneration, and cancer.The nature of ploidy-related advantages is still not completely understood.Here, we summarize the literature on molecular mechanisms underlying ploidy-related adaptive features.Polyploidy can regulate gene expression via chromatin opening, reawakening ancient evolutionary programs of embryonality.Chromatin opening switches on genes with bivalent chromatin domains that promote adaptation via rapid induction in response to signals of stress or morphogenesis.Therefore, stress-associated polyploidy can activate myc proto-oncogenes, which further promote chromatin opening.Moreover, myc proto-oncogenes can trigger polyploidization de novo and accelerate genome accumulation in already polyploid cells.As a result of these cooperative effects, polyploidy can increase the ability of cells to search for adaptive states of cellular programs through gene regulatory network rewiring.This ability is manifested in epigenetic plasticity associated with traits of stemness, unicellularity, flexible energy metabolism, and a complex system of dna damage protection, combining primitive error-prone unicellular repair pathways, advanced error-free multicellular repair pathways, and dna damage-buffering ability.These three features can be considered important components of the increased adaptability of polyploid cells.The evidence presented here contribute to the understanding of the nature of stress resistance associated with ploidy and may be useful in the development of new methods for the prevention and treatment of cardiovascular and oncological diseases.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article;Review
Google Trends Analysis Shows Increasing Public Interest in Platelet-Rich Plasma Injections for Hip and Knee Osteoarthritis.

Osteoarthritis is a chronic musculoskeletal condition that frequently affects the hip and knee joints.Given the burden associated with surgical intervention for hip and knee osteoarthritis, patients continue to search for potential nonoperative treatments.One biologic therapy with mixed clinical and basic science evidence for treating osteoarthritis is platelet-rich plasma injections into the affected joint.We used the google trends tool to provide a quantitative analysis of national interest in platelet-rich plasma injections for hip and knee osteoarthritis.Methods google trends parameters were selected to obtain search data from january 2009 to december 2019.Various combinations of "arthritis," "osteoarthritis," "prp," "platelet-rich plasma," "knee," and "hip" were entered into the google trends tool and trend analyses were performed.Results three linear models were generated to display search volume trends in the united states for platelet-rich plasma and osteoarthritis, hip osteoarthritis, and knee osteoarthritis, respectively.All models showed increased google queries as time progressed (p < .001), with r2ranging from 0.837 to 0.940.Seasonal, income-related, and geographic variations in public interest in platelet-rich plasma for osteoarthritis were noted.Conclusion our results demonstrate a significant rise in google queries related to platelet-rich plasma injections for osteoarthritis of the hip and knee since 2009.Surgeons treating hip and knee osteoarthritis patients can expect continued interest in platelet-rich plasma, despite inconclusive clinical and basic science data.Trends in public interest may inform patient counseling, shared decision-making, and directions for future clinical research.

Journal: The Journal of arthroplasty (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Increased risk for uterine cancer among first-degree relatives to Swedish gastric cancer patients.

In order to further understand genetically predisposing factors of gastric cancer, a retrospective study on 107 patients with gastric cancer was conducted.The family history of cancer cases was registered, in search of associations between gastric cancer and other cancer types.Materials and methods within stockholm county in sweden, all patients previously diagnosed with gastric cancer and still alive were invited to participate in the study.Patients were asked to complete a questionnaire about their gastric cancer diagnosis and if any cancers had occurred in their family.A blood sample for dna extraction was collected.The proportions of different cancer types in the relatives of the patients were compared to the general swedish population in 1970 and 2010.Results among first- and second-degree relatives to the index patients with gastric cancer, the frequency of uterine cancer as well as gastric cancer was significantly overrepresented compared to the general population in sweden.The frequency of breast cancer was significantly lower.Conclusions there seems to be an increased risk of both gastric cancer and uterine cancer in the families of gastric cancer survivors, indicating a possible hereditary connection between these two cancer types.

Journal: Hereditary cancer in clinical practice (2020)
Publication types: Journal Article
Setting the stage for speaking up: psychological safety and directing care in acute care collaboration.

Managing a safe and efficient anaesthetic induction within a team involves the challenge of when, if, and how to surface, discuss, and implement the best plan on how to proceed.The lemke and colleagues study in this issue of the british journal of anaesthesia is a unique view into real-world conversations that naturally occur in anaesthesia teams in moments of high task and cognitive load, such as induction of anaesthesia.The study spotlights important small moments of physician, nurse, and trainee team coordination.It illuminates key patterns of conversation in naturally occurring anaesthesia teams, and raises important questions about what the speaking up standard should be and the psychological safety-shaping role consultants play in setting the norms for speaking up.

Journal: British journal of anaesthesia (2022)
Publication types: Editorial;Comment
Menstrual Cycle Modulates Motor Learning and Memory Consolidation in Humans.

Numerous studies have noted that sex and/or menstrual phase influences cognitive performance (in particular, declarative memory), but the effects on motor learning (ml) and procedural memory/consolidation remain unclear.In order to test the hypothesis that ml differs across menstrual cycle phases, initial ml, overlearning, consolidation, and final performance were assessed in women in the follicular, preovulation and luteal phases.Primary motor cortex (m1) oscillations were assessed neuro-physiologically, and premenstrual syndrome and interoceptive awareness scores were assessed psychologically.We found not only poorer performance gain through initial ml but also lower final performance after overlearning a day and a week later in the luteal group than in the ovulation group.This behavioral difference could be explained by particular premenstrual syndrome symptoms and associated failure of normal m1 excitability in the luteal group.In contrast, the offline effects, i.e., early and late consolidation, did not differ across menstrual cycle phases.These results provide information regarding the best time in which to start learning new sensorimotor skills to achieve expected gains.

Journal: Brain sciences (2020)
Publication types: Journal Article
Association between obesity phenotypes in adolescents and adult metabolic syndrome: Tehran Lipid and Glucose Study.

Obesity phenotypes can be regarded as an indicator of cvd risk factors.The aim of the present study was to determine the prevalence of adolescents with different obesity phenotypes and the role of obesity phenotypes in prediction of the metabolic syndrome (met s) in adults.For this population-based cohort study, 2159 adolescents aged 11-18 years were included.Subjects were divided into four obesity phenotype groups: metabolically healthy normal weight (mhnw), metabolically healthy obese (mho), metabolically unhealthy normal weight (munw) and metabolically unhealthy obese (muo).Cox proportional hazard modelling was used to estimate the incidence of the met s in adults after a median follow-up of 11·3 years.The incidence rate of the met s in early adulthood was 111·6 (95 % ci 98·7, 126·3) per 10 000 person-years, with higher values in boys (210·1 (95 % ci 183·0, 241·3)), compared with girls (39·7 (95 % ci 30·2, 52·1)).In the age- and adult bmi-adjusted model, the hazard ratio of the met s in adulthood for boys was 3·33 (95 % ci 2·08, 5·32) among muo phenotype followed less than 6 years, 1·71 (95 % ci 1·01, 2·90) among mho, and 2·52 (95 % ci 1·72, 3·68) among munw.All associations were attenuated in girls except for muo phenotype followed less than 6 years (5·72 (95 % ci 2·14, 15·3)).In conclusion, munw and mho phenotypes in boys, but not in girls, and muo phenotype in both sexes with less than 6 years of follow-up increased the risk of adult met s compared with mhnw.It seems that lack of obesity at least in boys does not protect them from met s development in adulthood.

Journal: The British journal of nutrition (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A Non-Hereditary Case of Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome.

Hereditary leiomyomatosis and renal cell carcinoma (hlrcc) syndrome is believed to result from an autosomal dominant mutation in the fumarate hydratase (fh) gene on chromosome 1.It is characterized by leiomyomas, mainly uterine or cutaneous, and renal cell carcinoma (rcc).The most common type of rcc associated with hlrcc is type ii papillary rcc although other types are seen.Of note, chromophobe rcc has not been described in previously documented cases of hlrcc.Hlrcc is typically associated with germline mutations with occasional somatic mutations reported, however, to the best of our knowledge, none have yielded the full phenotype until now.Herein, we report a case of a 45-year-old woman who underwent a hysterectomy following a year of heavy vaginal bleeding, yielding a diagnosis of uterine leiomyomas.Eight months later, the patient presented with hematuria and was subsequently found to have a left renal mass.Following a left radical nephrectomy, histologic exam revealed a chromophobe rcc with fh deficiency.

Journal: Cureus (2021)
Publication types: Case Reports;Journal Article
Shared genetic links between amyotrophic lateral sclerosis and obesity-related traits: a genome-wide association study.

Epidemiological and clinical studies have suggested comorbidities between amyotrophic lateral sclerosis (als) and obesity-related traits.However, little is known about their shared genetic architecture.To examine whether genetic enrichment exists between als and obesity-related traits and to identify shared risk loci, we analyzed summary statistics from genome-wide association studies using the conditional false discovery rate statistical framework, and further conducted functional enrichment analysis.Robust genetic enrichment was observed for als conditional on body mass index, body fat percentage, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and type 2 diabetes.Nine shared genetic loci were identified, among which 6 were replicated in a second als cohort, including c9orf72, g2e3, scfd1, atxn3, clcn3 and ggnbp2.We further identified ggnbp2 as a novel als risk gene, by integrating summary data-based mendelian randomization analysis.Functional enrichment analysis indicated that the shared risk genes were involved in 2 pathways, namely membrane trafficking and vesicle-mediated transport.These results provide a better understanding for the pleiotropy of als and have implications for future therapeutic trials.

Journal: Neurobiology of aging (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The Black-Box Deconstruction of Dynamic Sustainable Development Ability Driving Environmental Performance of Manufacturing Enterprises

Based on the conceptual model of the black‐box deconstruction of dynamic sustainable development ability driving environmental performance of manufacturing enterprises, the nonparametric percentile bootstrap method based on deviation correction is used to demonstrate the theoretical hypothesis and empirically deconstruct the black‐box of dynamic sustainable development driving environmental performance.Empirical results show that (1) dynamic sustainable development ability has a positive influence on environmental performance; (2) green resource integration ability, green duality, low‐carbon manufacturing practice, and green intelligence capital play mediating roles in the influence of dynamic sustainable development ability on environmental performance; and (3) environmental regulation positively moderates the mediating mechanism of green resource integration ability, green duality, low‐carbon manufacturing practice, and green intelligence capital of the relationships between dynamic sustainable development ability and environmental performance.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
The Application of Color Psychology in Community Health Environment Design

The topic of health has gained importance in today’s society in the context of a healthy china.The success of community environmental design is intimately correlated with everyone’s physical and mental health since it is the setting for people’s daily lives.At present, although the facilities and equipment of the community environment in our country are improving day by day, the important role of color psychology in the community environment has been neglected.Color has always been a part of human life and a very important component of the community environment.When it comes to the design of communal environments, the color design of various areas will have variable degrees of influence on the psychological space and perspective of individuals.Therefore, the purpose of this paper is to investigate the application value of color psychology in the design of community health environments using color psychology as a scientific foundation.Additionally, the paper attempts to use color psychology as a scientific basis to study the thinking of health issues in the community environment.In addition, the results of the questionnaire survey are used to perform analysis and discussion in order to investigate the regular characteristics of the various research objects, as well as their preferences and psychological needs for color.This is done with the goal of providing empirical support for the improvement of the community environment and the health of the people living in it.In the end, the results of the questionnaire survey are compiled with four different design concepts.These design principles include functionality, naturalness, beauty, and safety.And the design intention and optimization strategy from the three directions the overall building, planting, and paving in the community healthy environment are then presented.This is done in order to create a colorful and comfortable healthy environment for the community life of people and to support the development of people’s physical and mental health.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
The Anesthetic Effect of Ultrasound-Guided Serratus Anterior Plane Block in Arthroscopic Shoulder Surgery and Its Effect on Postoperative Analgesia

To investigate the anesthetic effect of anterior serratus muscle plane block under ultrasound guidance in arthroscopic shoulder surgery and its effect on postoperative analgesia.Methods.A total of 94 patients who received arthroscopic shoulder surgery in our hospital were selected as the research subjects, and they were divided into a control group and a study group according to the random number table method.The control group underwent brachial plexus block under ultrasound guidance, and the study group underwent anterior serratus plane block under ultrasound guidance.The visual analogue score (vas) of pain at each time point, intraoperative anesthetic dosage, the use of postoperative analgesic, pain mediators and oxidative stress factors before and after surgery, and the occurrence of adverse reactions were compared between the two groups after surgery.Results.At 6, 12, 48, and 72 h after surgery, there was no obvious difference in the vas score between the two groups ( p &gt; 0.05 ); 24 h after surgery, the vas score of the study group was significantly lower than that of the control group ( p &lt; 0.05 ).The intraoperative dosage of propofol and remifentanil in the study group was significantly lower than that in the control group ( p &lt; 0.05 ).The number of effective compressions of analgesic pump and the total amount of sufentanil in the study group were significantly lower than those in the control group within 48 hours after operation, and the time of first compressions of analgesic pump was significantly longer than that in the control group ( p &lt; 0.05 ).Before surgery, there were no significant differences in cgrp, npy, and mda levels and sod enzyme activity between the two groups ( p &gt; 0.05 ).After surgery, the levels of pain mediators cgrp and npy in the study group were lower than those in the control group ( p &lt; 0.05 ).The level of mda was lower than that of the control group, and sod enzyme activity was higher than that of the control group ( p &lt; 0.05 ).There was no significant difference in the incidence of adverse reactions between the two groups ( p &gt; 0.05 ).Conclusion.Ultrasound-guided anterior serratus plane block for arthroscopic shoulder surgery has a good anesthesia effect and long action time.It can significantly reduce the dosage of opioids, enhance the postoperative analgesic effect, effectively inhibit postoperative pain and oxidative stress reaction, and has good safety.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Clinical Study;