syedzayyan/paper_mill_benchmark huggingface dataset:
Advisory opinion of the AWMF Ad hoc Commission In-vitro Diagnostic Medical Devices regarding in-vitro diagnostic medical devices manufactured and used only within health institutions established in the Union according to Regulation (EU) 2017/746 (IVDR).

In view of the approaching application date of regulation (eu) 2017/746 ("ivdr") and the resulting eu-wide, harmonized requirements for in-vitro diagnostic medical devices (ivd) manufactured and used within european health institutions, the ad hoc commission ivd of the german association of the scientific medical societies (awmf) takes a national position on the details of the requirements and conditions related to the use of these ivd products.The ad hoc commission ivd emphasizes the relevance of examination procedures developed in medical laboratories, especially in the field of orphan diseases and new diagnostic markers.The ivdr sets an adequate regulatory framework for ivd manufactured and used within health institutions as long as these requirements are fulfilled with reliability and in accordance with the current state of the art in medical laboratory sciences.At the same time, the ivdr requirements have to be regarded under a pragmatic view and in accordance with the quality management systems approved within the different eu member states.On the one hand, the mandatory requirements of the ri li bäk play an essential role in germany.On the other hand, elements of voluntarily applicable international standards may support the fulfilment of product requirements for safety and performance according to annex i of the ivdr.Both the complexity and possible solutions for the implementation of the ivdr requirements are discussed on the basis of examples such as the required documentation, performance evaluation and software validation.The ad hoc commission ivd recommends that, while aiming at a preferably eu-wide harmonized interpretation of the ivdr requirements, the flexibility in medical laboratory diagnostics necessary for patient care, including the use of ivd from in-house production, should be emphasized.

Journal: German medical science : GMS e-journal (2021)
Publication types: Journal Article
Temperature Influences on Powdery Mildew Susceptibility and Development in the Hop Cultivar Cascade.

The hop cultivar 'cascade' possesses partial resistance to powdery mildew (podosphaera macularis) that can be overcome by recently emerged, virulent isolates of the fungus.Given that hop is a long-lived perennial and that brewers still demand cascade, there is a need to better understand factors that influence the development of powdery mildew on this cultivar.Growth chamber experiments were conducted to quantify the effect of constant, transient, and fluctuating temperature on cascade before, concurrent to, and after inoculation as contrasted with another powdery mildew-susceptible cultivar, 'symphony'.Exposure of plants to supraoptimal temperature (26 and 32°c) before inoculation led to more rapid onset of ontogenic resistance in intermediately aged leaves in cascade as compared with symphony.Cascade was overall less susceptible to powdery mildew when exposed to constant temperature ranging from 18 to 32°c directly after inoculation.However, cultivar also interacted with temperature such that proportionately fewer and smaller colonies developed on cascade than symphony at supraoptimal yet permissive temperatures for disease.When plants were inoculated and then exposed to high temperature, colonies became progressively more tolerant to temperatures of 26 to 30°c with increasing time from inoculation to exposure, as moderated by cultivar, the specific temperature, and their interaction.Subjecting plants to simulated diurnal temperature regimes at the time of inoculation or 24 h later indicated cascade and symphony responded proportionately similarly on days predicted to be marginally unfavorable or marginally favorable for powdery mildew, although cascade was quantitatively less susceptible than symphony.In sum, this research indicates that cascade is overall less susceptible to powdery mildew than symphony, and supraoptimal temperature before, concurrent to, or after infection may interact differentially to moderate disease risk in cascade.Therefore, cultivar-specific risk assessments for powdery mildew appear warranted.

Journal: Plant disease (2022)
Publication types: Journal Article
Neutralization or enhancement of SARS-CoV-2 infection by a monoclonal antibody targeting a specific epitope in the spike receptor-binding domain.

Neutralizing antibodies (nabs) are believed to be promising prophylactic and therapeutic treatment against the coronavirus disease 2019 (covid-19), which is caused by severe acute respiratory syndrome coronavirus 2 (sars-co v-2).Here, we reported two mouse monoclonal antibodies 7 eb-4g and 1ba-3h that specifically recognized the receptor-binding domain (rbd) of sars-co v-2 spike (s) protein without exhibiting cross-reactivity with the s proteins of sars-co v and mers-co v.The binding epitopes of 7 eb-4g and 1ba-3h were respectively located in the regions of residues 457-476 and 477-496 in the s protein.Only 1ba-3h exhibited the neutralizing activity for preventing the pseudotyped lentivirus from binding to the angiotensin-converting enzyme 2 (ace2)-transfected hek293t cells.The competitive elisa further showed that 1ba-3h interfered with the binding between rbd and ace2.Epitope mapping experiments demonstrated that a single alanine replacement at residues 480, 482, 484, 485, and 488-491 in the rbd abrogated 1ba-3h binding.1ba-3h exhibited the neutralizing activity against the wild-type, alpha, delta, and epsilon variants of sars-co v-2, but lost the neutralizing activity against gamma variant in the plaque reduction assay.On the contrary, 1ba-3h enhanced the cellular infection of gamma variant in a dose-dependent manner.Our findings suggest that the antibody-dependent enhancement of infection mediated by the rbd-specific antibody for different sars-co v-2 variants must be considered while developing the nab.

Journal: Antiviral research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Case report: Two cases of primary paratesticular liposarcoma.

Paratesticular liposarcoma is a sporadic urological tumor.We report the clinical presentation, treatment course, and prognosis of 2 cases of primary paratesticular liposarcoma with different pathological types, with the aim of further understanding the diagnosis and treatment of this rare disease.Case 1 was a 53-years-old male patient who presented with left scrotal enlargement with swelling 3 years ago and was considered to have a testicular malignancy on preoperative ct scan and enhanced mri.The patient underwent resection of the left scrotal mass and left orchiectomy under general anaesthesia.Histopathological study confirmed the diagnosis of dedifferentiated liposarcoma.At the 4-months follow-up, no local recurrence or distant metastasis was observed.Case 2 is a 42-years-old male patient with a left scrotal mass which was discovered six months ago.Preoperatively, he underwent ct plain and enhanced mri examinations suggesting an intra-scrotal occupancy.The patient underwent scrotoscopic excision of the left scrotal mass under general anesthesia.Histopathological studies confirmed the diagnosis of highly differentiated liposarcoma.At the 10-months follow-up, no local recurrence or distant metastasis was observed.Preoperative differential diagnosis of paratesticular liposarcoma should be noted with testicular tumor and extra-abdominal hernia.Extensive local excision and, if necessary, concomitant radical testicular resection is the treatment of choice.If the tumor in the scrotum spreads to the inguinal region, surgical removal with the aid of a scrotoscope may be attempted.This procedure avoids the formation of a large incision in the inguinal region compared to traditional open surgery.Patients commonly experience local recurrence and less distant metastases after surgery, so long-term follow-up is recommended.

Journal: Frontiers in oncology (2022)
Publication types: Case Reports;Journal Article
The Association of Age With Clinical Presentation and Comorbidities of Pyoderma Gangrenosum.

Importance pyoderma gangrenosum is an inflammatory neutrophilic dermatosis.Current knowledge of this rare disease is limited owing to a lack of validated diagnostic criteria and large population studies.Objective to evaluate the association of age with the clinical presentation and comorbidities of pyoderma gangrenosum.Design, setting, and participants this was a multicenter retrospective cohort study performed at tertiary academic referral centers in urban settings.Adults (≥18 years) who were evaluated and diagnosed as having pyoderma gangrenosum at the brigham and women's and massachusetts general hospitals from 2000 to 2015 and the university of pennsylvania health system from 2006 to 2016 were included.Main outcomes and measures patient demographics, clinical features, medical comorbidities, and treatment.Results of the 356 validated cases of pyoderma gangrenosum included in the study, 267 (75%) were women and 284 (84.8%) were white.The mean (sd) age at presentation was 51.6 (17.7) years.Pathergy was recorded in 100 patients (28.1%).A total of 238 patients (66.9%) had associated medical comorbidities: inflammatory bowel disease in 146 patients (41.0%); inflammatory arthritis in 73 patients (20.5%); solid organ malignant neoplasms in 23 patients (6.5%); hematologic malignant neoplasms in 21 patients (5.9%); and hematologic disorders, specifically monoclonal gammopathy of undetermined significance, myelodysplastic syndrome, and polycythemia vera in 17 patients (4.8%).When stratified by age, pathergy was more common in patients 65 years or older (36.3% vs 24.3%; p = .02).Inflammatory bowel disease was the only medical comorbidity that was more common in patients younger than 65 years (47.7% vs 26.6%; p < .001), while a number of medical comorbidities were more common in those 65 years or older, including rheumatoid arthritis (13.3% vs 6.2%; p = .03), ankylosing spondylitis (1.8% vs 0%; p = .04), solid organ malignant neoplasms (13.3% vs 3.3%; p < .001), hematologic malignant neoplasms (9.7% vs 4.1%; p = .04), and the aforementioned hematologic disorders (10.6% vs 2.1%; p < .001).Conclusions and relevance although clinical presentation in this large cohort was similar between different age groups, disease associations varied by age.The findings of this study may allow for a more focused, age-specific evaluation of patients with pyoderma gangrenosum.

Journal: JAMA dermatology (2018)
Publication types: Journal Article;Multicenter Study;Research Support, Non-U.S. Gov't
Case Report: Endovascular Treatment of Chronic Atherosclerotic Renal Artery Total Occlusions with Failed Medical Therapy.

Current guidelines generally no longer support revascularization for chronic renal artery occlusive diseases because results from randomized controlled trials favor medical therapy over angioplasty.However, increasing reports indicate that patients with renal artery occlusion (rao) can benefit from revascularization under certain circumstances.Case summary here, we present a patient with renal artery stenosis (ras) who does not have refractory hypertension or fit any clinical trial inclusion criteria by far.Medical therapy failed to prevent the progression of ras in this patient, leading to total occlusion of his right renal artery.This patient had progressive renal insufficiency but recovered renal function after endovascular treatment.Conclusion this case demonstrates that angioplasty can be beneficial in selected rao patients, especially those with residual renal function and collateral perfusion.

Journal: Frontiers in surgery (2022)
Publication types: Case Reports;Journal Article
Business Cycle and Occupational Accidents in Korea.

Occupational accidents occur for a variety of reasons, such as unsafe behaviors of workers and insufficient safety equipment at the workplace, but there are also various economic and social factors that can impact working conditions and working environment.This study analyzed the relationship between changes in economic factors and the occurrence of occupational accidents in korea.Methods multilinear regression analysis was used as the analysis model.The general to specific method was also used, which consecutively removes statistically insignificant variables from a general model that includes dependent variables and lagged variables of dependent variables.Results the frequency of occupational accidents was found to have a statistically significant relationship to economic indicators.The monthly number of cases of occupational injury and disease and fatal occupational injuries were found to be closely related to manufacturing capacity utilization, differences in the production index in the services sector, and commencements of building construction.The increase in equipment investment indicators was found to reduce fatal occupational injuries.Conclusion the results of this study may be used to develop occupational accident trends or leading indicators, which in turn can be used by organizations that manage and monitor occupational accidents toward taking administrative action designed to reduce occupational accidents.The results also imply that short-term and mid- to long-term economic and social changes that can impact workers, workplaces and working conditions, and workplace organizations must be taken into account if more effective government policies are to be established and implemented toward further prevention of occupational accidents.

Journal: Safety and health at work (2020)
Publication types: Journal Article
COVID-19 recovery packages can benefit climate targets and clean energy jobs, but scale of impacts and optimal investment portfolios differ among major economies.

To meet the paris temperature targets and recover from the effects of the pandemic, many countries have launched economic recovery plans, including specific elements to promote clean energy technologies and green jobs.However, how to successfully manage investment portfolios of green recovery packages to optimize both climate mitigation and employment benefits remains unclear.Here, we use three energy-economic models, combined with a portfolio analysis approach, to find optimal low-carbon technology subsidy combinations in six major emitting regions: canada, china, the european union (eu), india, japan, and the united states (us).We find that, although numerical estimates differ given different model structures, results consistently show that a >50% investment in solar photovoltaics is more likely to enable co2emissions reduction and green jobs, particularly in the eu and china.Our study illustrates the importance of strategically managing investment portfolios in recovery packages to enable optimal outcomes and foster a post-pandemic green economy.

Journal: One earth (Cambridge, Mass.) (2022)
Publication types: Journal Article
Concentrations of urinary parabens and reproductive hormones in Iranian women: Exposure and risk assessment.

Parabens are antimicrobial preservatives in a variety of processed foods and beverages, cosmetics, pharmaceuticals, and personal care products.Parabens may be associated with reproductive and endocrine disorders among women of reproductive age.The first objective of this study was to examine the association between urinary parabens concentrations and follicle-stimulating hormone(fsh), luteinizing hormone (lh), and prolactin disorders.The second objective of this study was to calculate the hazard quotient (hq) and margin of exposure (moe) to assess the potential risk for endocrine disrupts for each woman based on urinary paraben concentrations.To address these two objectives, a cross-sectional study was designed in the imam reza hospital in kermanshah.The association between early morning urinary paraben concentrations and the serum of fasting blood specimens was analyzed using multivariable linear regressions adjusted for confounding variables (i.e., creatinine, age, body mass index, and time spent on physical activity).Among the 96 women who participated in the study, those with bmi> 25 and aged 18-40 years showed higher levels of total urinary parabens.The highest sum of urinary parabens (54,955.16 μg/l) was observed among the women who were using toothpaste several times per day.Almost all the parabens such as methyl paraben(me p), ethyl paraben(et p), propyl paraben(pr p), butyl paraben(bu p) had a positive and negative significant association with serum concentrations of fsh and lh (p-value 0.05).The margin of exposure (moe) approach calculated for all parabens (<10000) showed a potential risk in the studied population.The results suggested that parabens could adversely affect reproductive and endocrine systems in women.Further studies relying on long-term exposure to parabens are necessary to better understand the potential risk of the association between urinary parabens concentrations with reproductive hormones.

Journal: Toxicology reports (2022)
Publication types: Journal Article
Stigma: A Barrier in Supporting Nurse Well-Being During the Pandemic.

Public media and the nursing literature are replete with data and anecdotal stories evidencing the overwhelming impact to nurses' well-being during the covid-19 pandemic.Although many organizations have rallied and are providing robust services to support nurses through the pandemic, stigma (negative perceptions, attitudes, and discrimination) about mental health support is contributing to nurses' reluctance to use the many resources available to them.This article outlines strategies for reducing the stigma and eliminating the barriers associated with obtaining the mental and emotional well-being support and services that nurses need and deserve.

Journal: Nurse leader (2022)
Publication types: Journal Article
Swimming trajectories of a three-sphere microswimmer near a wall.

The hydrodynamic flow field generated by self-propelled active particles and swimming microorganisms is strongly altered by the presence of nearby boundaries in a viscous flow.Using a simple model three-linked sphere swimmer, we show that the swimming trajectories near a no-slip wall reveal various scenarios of motion depending on the initial orientation and the distance separating the swimmer from the wall.We find that the swimmer can either be trapped by the wall, completely escape, or perform an oscillatory gliding motion at a constant mean height above the wall.Using a far-field approximation, we find that, at leading order, the wall-induced correction has a source-dipolar or quadrupolar flow structure where the translational and angular velocities of the swimmer decay as inverse third and fourth powers with distance from the wall, respectively.The resulting equations of motion for the trajectories and the relevant order parameters fully characterize the transition between the states and allow for an accurate description of the swimming behavior near a wall.We demonstrate that the transition between the trapping and oscillatory gliding states is first order discontinuous, whereas the transition between the trapping and escaping states is continuous, characterized by non-trivial scaling exponents of the order parameters.In order to model the circular motion of flagellated bacteria near solid interfaces, we further assume that the spheres can undergo rotational motion around the swimming axis.We show that the general three-dimensional motion can be mapped onto a quasi-two-dimensional representational model by an appropriate redefinition of the order parameters governing the transition between the swimming states.

Journal: The Journal of chemical physics (2018)
Publication types: Journal Article
Social media exposure during COVID-19 lockdowns could lead to emotional overeating via anxiety: The moderating role of neuroticism.

China was a major hotspot during the beginning of the covid-19 pandemic.Several studies have reported changes in residents' eating behaviors and appetite during city wide lockdowns and home confinements.However, few have investigated how neuroticism interacts with the impact of covid-19 to influence eating behaviors during city lockdowns.Thus, the current study aims to establish a pathway model to understand social media exposure, negative affect, neuroticism, and their interaction with eating behaviors during the covid-19 lockdowns.We present data from 1,128 participants (mage = 24.34 ± 10.48 years) who completed an online survey between february 17 and 27, 2020.The extent of respondents' social media exposure, negative affect, eating behaviors, and desire for high-calorie food during city lockdowns, as well as the personality trait of neuroticism, were measured.Results show that city lockdowns and home confinements had a negative impact on residents' eating behaviors and appetite.Forty-eight percent of respondents showed moderate to constant emotional overeating, and respondents' desire for high-calorie food significantly increased.Correlation analysis showed that emotional overeating is positively associated with social media exposure, neuroticism, and anxiety.Then, a moderated mediation model was established, showing that heavy social media exposure could lead to emotional overeating through anxiety, and the association between social media exposure and anxiety varies depending on the extent of neuroticism.The current study provides novel insight into how the interaction of a personality trait and the stressful situation of covid-19 influence people's negative emotions and eating behaviors.

Journal: Applied psychology. Health and well-being (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
De novo designed transmembrane peptides activating the α5β1 integrin.

Computationally designed transmembrane α-helical peptides (champ) have been used to compete for helix-helix interactions within the membrane, enabling the ability to probe the activation of the integrins αiibβ3 and αvβ3.Here, this method is extended towards the design of champ peptides that inhibit the association of the α5β1 transmembrane (tm) domains, targeting the ala-x3-gly motif within α5.Our previous design algorithm was performed alongside a new workflow implemented within the widely used rosetta molecular modeling suite.Peptides from each computational approach activated integrin α5β1 but not αvβ3 in human endothelial cells.Two champ peptides were shown to directly associate with an α5 tm domain peptide in detergent micelles to a similar degree as a β1 tm peptide does.By solution-state nuclear magnetic resonance, one of these champ peptides was shown to bind primarily the integrin β1 tm domain, which itself has a gly-x3-gly motif.The second peptide associated modestly with both α5 and β1 constructs, with slight preference for α5.Although the design goal was not fully realized, this work characterizes novel champ peptides activating α5β1 that can serve as useful reagents for probing integrin biology.

Journal: Protein engineering, design & selection : PEDS (2018)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't