syedzayyan/paper_mill_benchmark huggingface dataset:
A Rather Universal Vibrational Resonance in 1:1 Hydrates of Carbonyl Compounds.

When the lower frequency oh stretching fundamental of a water molecule is shifted to the 3500 cm-1spectral range by the solvation of a carbonyl compound, in this case a ketone, its infrared intensity is shared with a dark state.It is shown by chemical and isotope substitution for more than a dozen systems that the location of this resonance is remarkably substitution-independent.Harmonic and anharmonic model calculations support its assignment to a combination of the water bending overtone and in-plane water libration.This previously unrecognized intramolecular-intermolecular coupling in single solvent water has a strength of 7-10 cm-1.It may have been sporadically observed before in a few other carbonyl compounds such as amides, without any previous exploration of its potential universality.The resulting generic picosecond energy redistribution channel for aqueous solutions may represent a slow counterpart and doorway model of what happens on a subpicosecond time scale when the hydrogen bonds become stronger, such as in carboxylic acid dimers or protonated water clusters.

Journal: The journal of physical chemistry letters (2021)
Publication types: Journal Article
Circulating C-Terminal Agrin Fragment: A Potential Marker for Sarcopenia Among Type 2 Diabetes.

Undetected onset of sarcopenia among individuals with chronic diseases especially type 2 diabetes mellitus (t2d) makes it important to be evaluated.The feasibility of diagnosing sarcopenia in a clinical setup might be a difficult task.Circulating markers including c-terminal agrin fragment (caf) are emerging as an alternative.Hence, the objectives of the study were to compare circulating caf levels between t2d, prediabetes (pd) and healthy controls and to study its association with sarcopenic index, muscle mass, strength and quality.Methods ninety-nine participants (n = 42, t2d; n = 33, pd; n = 24, healthy controls) aged 18 to 60 yrs were recruited.Homa (homeostatic model assessment) indices were derived using plasma glucose and insulin.All participants underwent lipid profiling, muscle strength including quality (isokinetic dynamometer), body composition (dual energy x-ray absorptiometry (dxa)) and sarcopenic index (appendicular skeletal muscle mass/body weight) assessment.Serum samples were used to estimate caf levelsusing enzyme-linked immunosorbent assay (elisa).Results median caf level was significantly higher among t2d group compared to pd and control groups (p < 0.0001).Circulating caf levels correlated positively with age and glycated haemoglobin (hb a1c) (both, p < 0.001) and negatively with homa-b and muscle quality (both, p < 0.001), and sarcopenic index (p = 0.07).Multivariable analysis demonstrated that the odds of being in the highest tertile category was 7.67, 95% c.i.(2.10, 29.3) among t2d.Conclusion circulating caf levels were significantly higher among t2d compared to pd and control study groups along with reduced skeletal muscle quality.This suggests that the circulating caf level has the potential to be considered as a clinical marker to evaluate sarcopenia among t2d.

Journal: Indian journal of endocrinology and metabolism (2022)
Publication types: Journal Article
The Relevance of Circadian Clocks to Stem Cell Differentiation and Cancer Progression.

The molecular mechanism of circadian clocks depends on transcription-translation feedback loops (ttfls) that have known effects on key cellular processes.However, the distinct role of circadian ttfls in mammalian stem cells and other less differentiated cells remains poorly understood.Neural stem cells (nscs) of the brain generate neurons and glia postnatally but also may become cancer stem cells (cscs), particularly in astrocytomas.Evidence indicates clock ttfl impairment is needed for tumor growth and progression; although, this issue has been examined primarily in more differentiated cancer cells rather than cscs.Similarly, few studies have examined circadian rhythms in nscs.After decades of research, it is now well recognized that tumors consist of cscs and a range of other cancer cells along with noncancerous stromal cells.The circadian properties of these many contributors to tumor properties and treatment outcome are being widely explored.New molecular tools and ones in development will likely enable greater discrimination of important circadian and non-circadian cells within malignancies at multiple stages of cancer progression and following therapy.Here, we focus on adult nscs and glioma cscs to address how cells at different stages of differentiation may harbor unique states of the molecular circadian clock influencing differentiation and cell fate.

Journal: NeuroSci (2022)
Publication types: Journal Article;Review
Construction of a two-dimensional DNA-RNA hybridized membrane for collecting tumor-derived exosomes.

Macroscopic nucleic acid-based structures have attracted much attention in biomedical fields.Here, we introduce a novel dna-rna hybridized membrane structureviaenzymatic dual polymerization.The membrane exhibited enhanced rigidity and functionality.Encoded with an aptamer, the membrane showed great potential as a collecting platform of tumor-derived exosomes without additional labeling.

Journal: Chemical communications (Cambridge, England) (2021)
Publication types: Journal Article
Cochrane Corner: Perioperative beta-blockers for preventing surgery-related mortality and morbidity.

Randomized controlled trials have yielded conflicting results regarding the impact of beta-blockers on perioperative cardiovascular morbidity and mortality.This cochrane systematic review assessed the impact of this intervention on mortality and cardiovascular events.Eighty-eight randomized controlled trials with 19 161 participants were included (53 trials on cardiac surgery and 35 trials on non-cardiac surgery).In cardiac surgery perioperative beta-blockers had a protective effect against supraventricular and ventricular arrhythmias but had no significant effect on mortality or on the occurrence of acute myocardial infarction (ami), stroke, heart failure, hypotension or bradycardia.In non-cardiac surgery, beta-blockers had a protective effect against ami and arrhythmias, but this was counterbalanced by an increased risk of death and stroke.In conclusion, perioperative use of beta-blockers appears overall to be beneficial in cardiac surgery.However, in non-cardiac surgery the substantial reduction in rhythm disturbances and ami appears to be offset by an increase in mortality and stroke, and so the systematic use of beta-blockers in this setting is not recommended.

Journal: Revista portuguesa de cardiologia (2019)
Publication types: Journal Article;Meta-Analysis;Systematic Review
Research on Bending and Ballistic Performance of Three-Dimensional Ply-to-Ply Angle Interlock Kevlar/EP Armor Material.

The three-dimensional (3d) shallow cross-bending composite material has many advantages in thickness and in-plane direction, such as high strength, high modulus, inter-layer shear strength, as well as large-area area bearing, energy absorption, etc., which has great application potential in the field of bulletproof armor.To prepare a protective material with both excellent bending performance and good ballistic performance, the effects of weft density and layering method on the bending performance and ballistic performance of three-dimensional ply-to-ply angle interlock (3dppai) kevlar/ep armor materials were studied.The results showed that when the weft density of the material was 33 pieces/cm, its bending performance and ballistic resistance were the best.The 3dppai kevlar/ep armor material prepared by orthogonal layup had more advantages in bending performance, and the unidirectional layup had better anti-ballistic performance.The research results will lay the foundation for structural optimization and engineering applications of such materials.

Journal: Materials (Basel, Switzerland) (2022)
Publication types: Journal Article
Untargeted serum metabolomic profiling for early detection ofSchistosoma mekongiinfection in mouse model.

Mekong schistosomiasis is a parasitic disease caused by blood flukes in the lao people's democratic republic and in cambodia.The standard method for diagnosis of schistosomiasis is detection of parasite eggs from patient samples.However, this method is not sufficient to detect asymptomatic patients, low egg numbers, or early infection.Therefore, diagnostic methods with higher sensitivity at the early stage of the disease are needed to fill this gap.The aim of this study was to identify potential biomarkers of early schistosomiasis using an untargeted metabolomics approach.Serum of uninfected and s.Mekongi-infected mice was collected at 2, 4, and 8 weeks post-infection.Samples were extracted for metabolites and analyzed with a liquid chromatography-tandem mass spectrometer.Metabolites were annotated with the ms-dial platform and analyzed with metaboanalyst bioinformatic tools.Multivariate analysis distinguished between metabolites from the different experimental conditions.Biomarker screening was performed using three methods: correlation coefficient analysis; feature important detection with a random forest algorithm; and receiver operating characteristic (roc) curve analysis.Three compounds were identified as potential biomarkers at the early stage of the disease: heptadecanoyl ethanolamide; picrotin; and theophylline.The levels of these three compounds changed significantly during early-stage infection, and therefore these molecules may be promising schistosomiasis markers.These findings may help to improve early diagnosis of schistosomiasis, thus reducing the burden on patients and limiting spread of the disease in endemic areas.

Journal: Frontiers in cellular and infection microbiology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Constrains for seeking post-abortion care among adolescents and young women in Guangzhou, China: a cross-sectional study.

In china, post-abortion care (pac) services mainly focus on married couples, such that adolescents and unmarried young womenhave limited access to those services for contraception counseling.The provision of youth-friendly pac services in public hospitals is a new concept in china.This study examined the magnitude of pac services utilization as well as factors influencing it's uptake among adolescents and young women in guangzhou, china.Methods a cross-sectional study was performed from 1st march 2020 to 30th september 2020 using anonymous self-administered questionnaire among 688 women aged 15-24 years in tianhe district, guangzhou.The multivariate logistic regression was used to determine factors that were significantly associated with the uptake of pac services.Results the magnitude of pac services utilization was 35.9% among adolescents and young women in guangzhou, china.Students were 69.0% significantly less likely to use pac services compared to women who had no job.Immigrants were 59.0% significantly less likely to use pac services than their native counterparts.Women who had a feeling of stigma were 70.0% significantly less likely to use pac services compared to those who did not feel stigmatized.Conclusions the study highlights the need to strengthen youth-friendly pac services provision, and emphasizes the importance of education about both family planning and abortion services among disadvantaged sub-groups of women in the study setting.

Journal: BMC health services research (2021)
Publication types: Journal Article
Angiography with the 256-multislice spiral computed tomography and its application in evaluating atherosclerotic plaque and cerebral ischemia.

Ulceration of carotid arterial plaque is associated with cerebral events.Detection of ulcerated plaques will benefit patient from stroke and other ischemic events.The aim of this study was to evaluate morphology of atherosclerotic plaques in the carotid arteries and to assess its clinical impact in predicting cerebral events.a total of 386 patients were examined with 256-multislice spiral computed tomographic angiography (mscta).it was found that 356 of the 386 patients had cerebral ischemic symptoms.Specifically, 35 patients had amaurosis fugax (am f), 178 had transient ischemic attack (tia), and 143 had ischemic stroke.Abnormal images were found in 658 carotid arteries by mscta.Of the 658 abnormal images of carotid arteries, besides the 34 cases of carotid arterial occlusion, 624 cases were atherosclerotic plaques.Of the 624 plaques, 394 (63.2%) were smooth surface plaques, 161 (25.8%) were irregular surface plaques, and 69 (11.1%) were ulcerated plaques.Incidence of ulcerated plaque was higher in the ischemic stroke patients (13.1%) compared with that in the tia group (10.3%), am f group (6.6%), or symptom-free group (9.4%) although it was not statistically significant (p = .288).However, there was significant difference in the incidence of ischemic stroke between the ulcerated (20/69, 28.9%) and nonulcerated groups (69/555, 12.4%, p < .05, odds ratio = 2.875).these findings suggested that 256-mscta is an advanced imaging tool to determine not only arterial stenosis but also morphologic assessment of atherosclerotic plaques, which will benefit the patients by predicting the cerebral events in advance.

Journal: Medicine (2018)
Publication types: Journal Article
Factors Influencing Sleep Quality in Open-Heart Patients in the Postoperative Intensive Care Unit.

Open-heart patients often experience sleep problems postoperatively.This cross-sectional study is aimed to investigate open-heart patients' sleep quality and its influencing factors during intensive care.A consecutive sample of 117 eligible open-heart patients was recruited from an intensive care unit (icu) of a general hospital.Data were collected using questionnaires.The respondents were 22-88 years, with a median age of 60.25 (13.51).Seventy-nine (67.5%) respondents were male.Most respondents reported a low-to-moderate postoperative pain level (average pain score = 2.02; range: 0-10).The average anxiety score was 4.68 (standard deviation [sd] = 4.2), and the average depression score was 6.91 (sd = 4.52; range: 0-21).The average sleep efficiency index was 70.4% (sd = 10.74%).Most (95.7%) respondents had a sleep efficiency index below 85%, indicating that most patients did not sleep well in the icu.Linear regression analysis showed that the key predictors of the sleep quality of open-heart patients in the icu were wound pain (β = -1.9) and noise disturbance (β = -1.86).These results provide information on sleep quality and the factors affecting postoperative patients in the icu.These findings can be used as a reference for developing relevant interventions.

Journal: Healthcare (Basel, Switzerland) (2022)
Publication types: Journal Article
External validation of clinical decision rules for children with wrist trauma.

Clinical decision rules help to avoid potentially unnecessary radiographs of the wrist, reduce waiting times and save costs.Objective the primary aim of this study was to provide an overview of all existing non-validated clinical decision rules for wrist trauma in children and to externally validate these rules in a different cohort of patients.Secondarily, we aimed to compare the performance of these rules with the validated amsterdam pediatric wrist rules.Materials and methods we included all studies that proposed a clinical prediction or decision rule in children presenting at the emergency department with acute wrist trauma.We performed external validation within a cohort of 379 children.We also calculated the sensitivity, specificity, negative predictive value and positive predictive value of each decision rule.Results we included three clinical decision rules.The sensitivity and specificity of all clinical decision rules after external validation were between 94% and 99%, and 11% and 26%, respectively.After external validation 7% to 17% less radiographs would be ordered and 1.4% to 5.7% of all fractures would be missed.Compared to the amsterdam pediatric wrist rules only one of the three other rules had a higher sensitivity; however both the specificity and the reduction in requested radiographs were lower in the other three rules.Conclusion the sensitivity of the three non-validated clinical decision rules is high.However the specificity and the reduction in number of requested radiographs are low.In contrast, the validated amsterdam pediatric wrist rules has an acceptable sensitivity and the greatest reduction in radiographs, at 22%, without missing any clinically relevant fractures.

Journal: Pediatric radiology (2017)
Publication types: Journal Article
Small Area Variations in Dietary Diversity Among Children in India: A Multilevel Analysis of 6-23-Month-Old Children.

Dietary diversity is an important indicator of child malnutrition.However, little is known about the geographic variation of diet indicators across india, particularly within districts and across states.As such, the purpose of this paper was to elucidate the small area variations in diet indicators between clusters within districts of india.Overall, we found that clusters were the largest source of variation for children not eating grains, roots, and tubers, legumes and nuts, dairy, vitamin a-rich vegetables and fruits, and other vegetables and fruits.We also found positive correlations between the district percent and cluster standard deviations of children not breastfeeding or eating grains, roots, and tubers, but negative correlations between the district percent and cluster standard deviation for the remaining seven outcomes.These findings underscore the importance of targeting clusters to improve child dietary diversity.

Journal: Frontiers in nutrition (2021)
Publication types: Journal Article
High bone union rate using a locking plate for proximal humeral fractures in patients older than 70 years: importance of the medial column.

This study aimed to evaluate the results of surgical treatment for proximal humeral fractures using a locking plate in patients aged > 70 years.Methods between september 2010 and march 2018, we retrospectively analyzed the clinical and radiological outcomes of 56 patients aged > 70 years who underwent locking plate fixation for proximal humeral fractures.We analyzed bone union, neck-shaft angle, university of california los angeles (ucla) score, range of motion (compared to that of the opposite side), and complications.Further, clinical and radiological results of unstable medial column fractures were investigated.Results fifty-four patients (96.2%) achieved bone union.The mean time to bone union was 14.7 ± 1.2 weeks, and the mean neck-shaft angle was 126.4° ± 14.2°.The mean ucla shoulder score was 22.4 ± 6.5.The mean forward flexion, abduction, and external rotation angles were 129.2° ± 19.4°, 112.3° ± 14.8°, and 44.2° ± 18.5°, respectively, with internal rotation to l2/3 (s-t11).The range of motion was significantly different from that in the opposite shoulder motion.Unstable medial column fractures led to a significant loss in the neck-shaft angle compared with fractures with an intact medial cortex.Conclusion for the surgical treatment of proximal humeral fractures in patients aged > 70 years, using a locking plate helped achieve a high bone union rate with relatively satisfactory results.However, the prevalence of unstable medial column fracture was high.Clinical and radiological outcomes were poor in these patients.Therefore, it is necessary to accurately understand the fracture pattern prior to surgery, and various surgical methods, including conservative treatment, should be considered.

Journal: European journal of trauma and emergency surgery : official publication of the European Trauma Society (2022)
Publication types: Journal Article
Are we still on the right path(way)?: the altered expression of the pentose phosphate pathway in solid tumors and the potential of its inhibition in combination therapy.

Introduction the pentose phosphate pathway (ppp) branches from glycolysis and is crucial for cell growth, since it provides necessary compounds for anabolic reactions, nucleotide synthesis, and detoxification of reactive-oxygen-species (ros).Overexpression of ppp enzymes has been reported in multiple cancer types and linked to therapy resistance, making their inhibition interesting targets for anti-cancer therapies.Areas covered this review summarizes the extent of ppp upregulation across different cancer types, and the non-metabolic functions that ppp-enzymes might contribute to cancer initiation and maintenance.The effects of ppp-inhibition and their combinations with chemotherapeutics are summarized.We searched the databases provided by the university of amsterdam to characterize the altered expression of the ppp across different cancer types, and to identify the effects of ppp-inhibition.Expert opinion it can be concluded that there are synergistic and additive effects of ppp-inhibition and various classes of chemotherapeutics.These effects may be attributed to the increased susceptibility to ros.However, the toxicity, low efficacy, and off-target effects of ppp-inhibitors make application in clinical practice challenging.Novel inhibitors are currently being developed, which could make ppp-inhibition a potential therapeutic strategy in the future, especially in combination with conventional chemotherapeutics and the inhibition of other metabolic pathways.

Journal: Expert opinion on drug metabolism & toxicology (2022)
Publication types: Journal Article;Review
An Immunoregulatory Role of Interleukin-3 in Allergic Asthma.

Allergic asthma is a chronic airway inflammatory disease associated with airway mucus hyper-production.Ilc2 cells, which express the th2 transcription factor gata3, have been associated with allergic asthma.The cytokine il-3 is known to support eosinophil, basophil and mucosal mast cell differentiation and survival; however, its role on t regulatory cells as well as on lung ilc2 and in pediatric asthma needs further investigation.Objectives to investigate the role of il-3 in preschool children and to explore its therapeutic role in experimental asthma.Methods in a cohort of preschool children with and without asthma, we analyzed the secretion of il-3 in nasopharyngeal fluid (npf) and il-3 receptor (r) alpha chain m rna expression in peripheral blood mononuclear cells (pbmcs).In a murine model of allergic asthma, we analyzed the phenotype of wild-type untreated and r il-3 intranasally treated asthmatic mice.Results il-3 was found downregulated in the nasopharyngeal fluid of children with partially controlled asthma, as compared to control children.Moreover, il-3 was found induced in phytohemagglutinin (pha)-stimulated pbmcs from children with asthma and treated with steroids.Finally, il-3 in npf directly correlated with the anti-inflammatory molecule s st2 in steroid-treated asthmatic children.Intranasal r il-3 deliveryin vivoduring the challenge phase decreased airway mucus production and inflammatory eosinophils.Moreover, r il-3 given during the challenge phase, reduced lung st2int gata3+ilc2, accompanied by an induction of t regulatory cells in the airways.Conclusions il-3 was found associated with steroid-resolved asthma.Moreover, treatment with r il-3 resulted in amelioration of airway eosinophilia and mucus production, two main pathophysiological conditions associated with asthma in a murine model of allergic asthma.Thus, r il-3 opens new strategies for immunotherapy of this disease.

Journal: Frontiers in immunology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't