syedzayyan/paper_mill_benchmark huggingface dataset:
Medial compartment cartilage repair and lower extremity biomechanical changes after single-plane high tibial osteotomy of distal tibial tuberosity.

To observe the cartilage repair of the medial compartment and the biomechanical changes of the lower extremities after single-plane high tibial osteotomy of distal tibial tuberosity (dtt-hto).Methods a total of 30 patients, including 11 males and 19 females, who underwent dtt-hto with arthroscopic operation in our hospital from january 2020 to january 2021 and underwent arthroscopic exploration again during the second operation for internal fixation were enrolled.There were 32 knees, including 13 left knees and 19 right knees.Age ranged from 50 to 78, with an average of 63.20 ± 6.61 years old.All patients completed two surgeries and were followed up, and no adverse events occurred during the period.International cartilage repair society (icrs) was used to assess the cartilage condition of the medial compartment of the knee during the two surgeries.In this paper, the weight-bearing line ratio (wblr), the medial proximal tibia angle (mpta), the femoral tibial angle (fta) and the posterior tibial slope (pts) were used to evaluate the changes of the mechanical state of the lower limbs.The visual analogue scale (vas) score and the western ontario and mc master university osteoarthritis (womac) index score were used to evaluate the improvement in knee pain and function.Results all patients completed two operations without adverse events and serious complications.The medial compartment cartilage of all patients had different degrees of repair during the second operation, and the difference was statistically significant compared with the first operation (p 0.05).At the second operation, the vas score decreased from 7.50 ± 1.34 to 0.34 ± 0.85, the womac score decreased from 119.50 ± 10.43 to 46.25 ± 4.13, and the difference was statistically significant (p < 0.05).Conclusion dtt-hto can significantly correct the weight-bearing line, restore the biomechanical parameters of the lower limb to the normal range, significantly relieve pain and improve knee function, and the medial compartment cartilage repair and regeneration phenomenon will occur after the correction of the weight-bearing line.

Journal: Computer methods and programs in biomedicine (2022)
Publication types: Journal Article
Lower cranial nerve syndromes: a review.

The purpose of this paper is to provide a comprehensive review encompassing the syndromes associated with the lower cranial nerves (lcns).We will discuss the anatomy of some of these syndromes and the historical contributors after whom they were named.The lcns can be affected individually or in combination, since the cranial nerves at this level share their courses through the jugular foramen and hypoglossal canal and the extracranial spaces.Numerous alterations affecting them have been described in the literature, but much remains to be discovered on this topic.This paper will highlight some of the subtle differences among these syndromes.Symptoms and signs that have localization value for lcn lesions include impaired speech, deglutition, sensory functions, alterations in taste, autonomic dysfunction, neuralgic pain, dysphagia, head or neck pain, cardiac or gastrointestinal compromise, and weakness of the tongue, trapezius, or sternocleidomastoid muscles.To assess the manifestations of lcn lesions correctly, precise knowledge of the anatomy and physiology of the area is required.Treatments currently used for these conditions will also be addressed here.Effective treatments are available in several such cases, but a precondition for complete recovery is a correct and swift diagnosis.

Journal: Neurosurgical review (2021)
Publication types: Journal Article;Review
Confusing terminology used in the abbreviation of pharmacy journal names.

The lack of commonly agreed terminology in pharmacy field is highly prevalent and may have influence on the relevance and robustness of the area, especially how others see pharmacy literature.Potential consequences of this poor perception of pharmacy field by the national library of medicine (nlm) could be the omission of several pharmacy-related medical subject headings (me sh) or the low indexing rate of pharmacy practice journals in medline.Journal name abbreviation, under the responsibility of the nlm, is the unambiguous way to identify a journal in bibliographic references and catalogs.The present study investigated the consistency of pharmacy journal abbreviations in the nlm catalog.For the 290 journals containing any word with the root pharm in their names, a consistent procedure for nlm title abbreviations was found for 27 of the words in journal names but not for the abbreviation "pharm", which represented several words with very different meanings: pharmaceutical, pharmaceutics, pharmacists, and pharmacy.The use by the nlm of different abbreviation for pharmaceutical and pharmaceutics would increase journal identification clarity.

Journal: Research in social & administrative pharmacy : RSAP (2022)
Publication types: Journal Article
A novel prognostic signature based on cuproptosis-related lncRNA mining in colorectal cancer.

Colorectal cancer (crc) is a common malignant tumor that affects the large bowel or the rectum.Cuproptosis, recently discovered programmed cell death process, may play an important role in crc tumorigenesis.Long non-coding rnas (lnc rnas) can alter the proliferation of colorectal cancer cells through the control and activation of gene expression.To date, cuproptosis-related lnc rnas, have not been investigated as potential predictive biomarkers in colorectal cancer.methods:the m rna and lnc rna expression data of colorectal cancer were gathered from the tumor genome atlas (tcga) database, and pearson correlation analysis and univariate cox regression analysis were used to identify the lnc rnas with differential prognosis.Colorectal cancer was classified using consistent clustering, and the clinical significance of different types, tumor heterogeneity, and immune microenvironment differences was investigated.The differential lnc rnas were further screened using lasso regression to develop a risk scoring model, which was then paired with clinicopathological variables to create a nomogram.Finally, the copy number changes in the high-risk and low-risk groups were compared.results:two clusters were formed based on the 28 prognostic cuproptosis-related lnc rnas, and the prognosis of cluster 2 was found to be significantly lower than that of cluster 1.Cluster 1 showed increased immune cell infiltration and immunological score, as well as strong enrichment of immune checkpoint genes.Next, lasso regression was used to select 11 distinctive lnc rnas, and a risk score model was constructed using the training set to distinguish between high and low-risk groups.Patients in the high-risk group had a lower survival rate than those in the low-risk group, and both the test set and the total set produced consistent results.The auc value of the roc curve revealed the scoring model's efficacy in predicting long-term os in patients.Moreover, the model could be used as an independent predictor when combined with a multivariate analysis of clinicopathological features, and our nomogram could be used intuitively to predict prognosis.conclusion:collectively, we developed a risk model using 11 differential lnc rnas and demonstrated that the model has predictive value as well as clinical and therapeutic implications for predicting prognosis in crc patients.

Journal: Frontiers in genetics (2022)
Publication types: Journal Article
Orientin relieves lipopolysaccharide-induced acute lung injury in mice: The involvement of its anti-inflammatory and anti-oxidant properties.

Oxidative stress and inflammatory responses are nearly involved in the pathogenesis of various diseases, including acute lung injury (ali).Orientin (ori), a flavonoid component extracted from natural plants, displayed anti-inflammatory and antioxidant properties in our previous studies.In the current study, we aimed to investigate the amelioration effect of ori on lipopolysaccharide (lps)-induced ali, and we further explored the potential molecular mechanisms.The present results indicated that ori effectively alleviated lps-induced ali by improving the histological changes of lung; decreasing the lung w/d ratio and protein levels, the release of inflammatory cells and cytokines into the bronchoalveolar lavage fluid (balf); inhibiting nitric oxide synthase (i nos), cyclooxygenase-2 (cox-2) and high mobility group box 1 (hmgb1) protein expression; reducing malondialdehyde (mda) formation and reactive oxygen species (ros) generation; and increasing the content of glutathione (gsh) and superoxide dismutase (sod) contents.Moreover, ori treatment not only significantly suppressed the lps-induced nucleotide-binding domain (nod)-like receptor protein 3 (nlrp3) inflammasome, and nuclear factor-kappa b (nf-κb) signaling pathway activation, but also obviously restored the expression of nuclear factor erythroid 2-related factor 2 (nrf2), nad (p) h: quinone oxidoreductase (nqo1), glutamate-cysteine ligase catalytic (gclc), and heme oxygenase 1 (ho-1) expression in the lung; all of which are reduced by lps.Taken together, these data suggested that ori plays an important role in the protection against ali by suppressing inflammation and oxidative stress which may be strongly related to the suppression of nlrp3 inflammasome and nf-κb activation, as well as the upregulation of the nrf2 signaling pathway.

Journal: International immunopharmacology (2021)
Publication types: Journal Article
α-Tocopherol application as a countermeasure to UV-B stress in bread wheat (Triticum aestivum L.).

The source of energy for all photoautotrophic organisms is light, which is absorbed by photosynthetic processes and used to transform carbon dioxide and h2o into organic molecules.The majority of uv-b light (280 to 320 nm) is absorbed by stratospheric ozone layer, although some of it does reach at the earth's surface.Because of the sedentary lifestyle of plants, this form of abiotic stress is unavoidable and can induce growth and even cell death.Ten-day-old calli generated from mature kirik wheat embryos were subjected to uv-b radiation for 0, 2, 4, and 6 h to examine the function of exogenous α-tocopherol, a lipophilic antioxidant, in wheat tolerance to uv-b radiation stress.The calli were then moved to a callus medium containing α-tocopherol (0, 50, and 100 mg/l) and cultivated there for 20 days after being subjected to uv-b stress.For plant regeneration, embryogenic calli were put on a medium for plant regeneration after 30 days.The findings of this investigation demonstrated that an increase in uv-b exposure period resulted in a substantial drop in the relative growth rate of callus, the rate of embryogenic callus, the rate of responding embryogenic callus, and the number of plants in each explant.On the other hand, with the application of α-tocopherol, all these parameters improved, and the best result was observed in the application of 100 mg/l of α-tocopherol in terms of plant regeneration under uv-b stress.

Journal: Environmental science and pollution research international (2023)
Publication types: Journal Article
Cardiovascular disease in women: A review of spontaneous coronary artery dissection.

Research has demonstrated the disproportionate quality of care for women with cardiovascular disease.These findings have prompted a renewed focus on cardiovascular disease awareness and disease prevention in women.Spontaneous coronary artery dissection (scad) is a significant cause of myocardial infarction (mi) and sudden death that primarily affects women.Ongoing research has led to improved diagnostic capabilities and changes in approaches to initial and long-term management most importantly this research has provided evidence that scad is more common than previously thought and must be evaluated and treated differently from atherosclerotic mi.The difference between scad and atherosclerotic mi is highlighted in high rates of recurrent disease, gender distribution, association with exogenous hormones, pregnancy, migraine, physical and emotional stress triggers, concurrent systemic arteriopathies, and connective tissue disease.In this review, we provide updated insights and a summary of the epidemiology, risk factors, clinical presentation, diagnosis, treatment options, prognosis, and recurrence prevention of scad.We aim to provide a review of scad as a focus on cardiovascular disease awareness and disease prevention in women.

Journal: Medicine (2022)
Publication types: Journal Article;Review
Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NF-κB pathway activation.

Type 2 diabetes mellitus (t2dm) and nonalcoholic fatty liver disease (nafld) are the most problematic metabolic diseases in the world.Nafld encompasses a spectrum of severity, ranging from simple steatosis to non-alcoholic steatohepatitis (nash) and fibrosis, increasing the risk of cirrhosis and hepatocellular carcinoma.Importantly, nafld is closely linked to obesity and tightly interrelated with insulin resistance and t2dm.T2dm and nafld (t2dm-nafld) are called as the xike rixijing disease and tonglaga indigestion disease respectively, in mongolian medicine.Xike rixijing disease maybe develop into tonglaga indigestion disease.Forturnately many mongolian medicines show efficient treatment of t2dm-nafld, such as agriophyllum squarrosum, haliyasu (dried powder of camel placenta), digeda-4 (herbs of lomatogonium carinthiacum, rhizomata of coptis chinensis, ripe fruits of gardenia jasminoides, herbs of dianthus superbus), guangmingyan siwei decoction powder (halite, ripe fruits of terminalia chebula, rhizomata of zingiber officinale, fruit clusters of piper longum), tonglaga-5 (ripe fruits of punica granatum, barks of cinnamomum cassia, ripe fruits of amomum kravanh, fruit clusters of piper longum, flowers of carthamus tinctorius), tegexidegeqi (rhizomata of inula helenium, ripe fruits of gardenia jasminoides, rhizomata of platycodon grandiflorum, rhizomata of coptis chinensis, heartwood of caesalpinia sappan), ligan shiliu bawei san (ripe fruits of punica granatum, barks of cinnamomum cassia, ripe fruits of amomum kravanh, fruit clusters of piper longum, flowers of carthamus tinctorius, ripe fruits of amomum tsao-ko, rhizomata of zingiber officinale), etc.Principles of mongolian medicine in treating diseases: by balancing "three essences or roots" and "seven elements", strengthening liver and kidney function, transporting nutrients to enhance physical strength and disease resistance, and combined with drugs for comprehensive conditioning treatment.However, their molecular mechanisms remain unclear.In this review, we prospect that mongolian medicines might be a promising treatment for t2dm-nafld by activating p2x7r/nlrp3/nf-κb inflammatory pathway via lipid-sensitive nuclear receptors (i.e., fxr and lxr).

Journal: Chinese herbal medicines (2022)
Publication types: Journal Article;Review
Mussel-Inspired Reversible Molecular Adhesion for Fabricating Self-Healing Materials.

Nature offers inspiration for the development of high-performance synthetic materials.Extensive studies on the universal adhesion and self-healing behavior of mussel byssus reveal that a series of reversible molecular interactions occurring in byssal plaques and threads play an essential role, and the mussel-inspired chemistry can serve as a versatile platform for the design of self-healing materials.In this perspective, we provide an overview of the recent progress in the detection, quantification, and utilization of mussel-inspired reversible molecular interactions, which includes the elucidation of their binding mechanisms via force-measuring techniques and the development of self-healing materials based on these dynamic interactions.Both conventional catechol-medicated interactions and newly discovered chemistry beyond the catechol groups are discussed, providing insights into the design strategies of advanced self-healing materials via mussel-inspired chemistry.

Journal: Langmuir : the ACS journal of surfaces and colloids (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't
Isolated Liver Rejection After Lung and Combined Kidney-Liver Transplantation: A Case Report.

Liver allografts are unique in solid organ transplantation as they are less susceptible to both acute and chronic rejection.Operational tolerance, defined as prolonged graft survival in the absence of immunosuppression, is also achieved more frequently with liver allografts.It is unknown if the presence of multiple allografts in the same individual, levels of immunosuppression, or the presence of cystic fibrosis (cf) impacts the livers ability to ward off rejection or achieve operational tolerance.We describe an unsensitized, abo-compatible patient with cf who underwent double lung transplantation and several years later a combined liver-kidney transplant.He developed isolated late acute t-cell mediated rejection of his liver allograft despite a high level of immunosuppression (is) required for his lung and kidney allografts.To our knowledge, this is the first case of isolated liver rejection in a patient with 3 separate organ allografts, or in a patient with cf, to be reported in the literature.This isolated liver rejection is out of keeping with typically accepted ideas about orthotopic liver tolerance.

Journal: Transplantation proceedings (2021)
Publication types: Case Reports;Journal Article
Cerebrospinal Fluid Leakage to the Chest Subcutaneous Pocket Due to Aggressive Brain Edema around the Leads for Deep Brain Stimulation: A Case Report and Literature Review.

Cerebral edema around the lead has been reported as a complication of deep brain stimulation; however, the causes remain unknown.Herein, we present a rare case of sudden cerebral edema around the lead occurring after deep brain stimulation.This was accompanied by cerebrospinal fluid (csf) leakage into the subcutaneous thoracic pocket around the implantable pulse generator in a 53-year-old man with parkinson's disease.No such case has been reported thus far.Lumbar drainage was performed to improve csf leakage.The cerebral edema initially responded to steroids, but then it stopped responding to treatment.The edema appeared alternately on the left and right sides, and cyst formation was noted around the left lead.There are some reports of cyst formation around the lead; however, in our case, images were used to monitor the edema and cyst from their appearance to their disappearance.Our data suggest that cyst formation and cerebral edema are related.

Journal: NMC case report journal (2022)
Publication types: Case Reports;Journal Article
"Maybe what happened is actually OK?" Child sexual abuse by authority figures in the ultra-orthodox community in Israel: Survivors' perceptions of their relationships with the perpetrator.

Child sexual abuse (csa) by authority figures in a religious community (afrcs) has been studied extensively among the catholic clergy, and to a limited extent among orthodox jewish communities in the united states and australia.However, less attention has been devoted to the phenomenon within the israeli context.Objective this article examines the perceptions of survivors within the ultra-orthodox jewish community in israel of their relationships with authority figures in the community who sexually abused them.Methods 21 in-depth interviews were conducted with men who were abused by authority figures within ultra-orthodox institutions, which were analyzed based on a thematic approach (braun & clarke, 2006).Results the results indicated that in childhood, almost none of the participants recognized that they were sexually abused.Their relationships with the authority figures were instead perceived as one of four variations: (1) normative-educative; (2) mutual; (3) an episode in a hypersexual routine; or (4) abusive punitive.Perceptions later shifted, mostly in adulthood, towards a recognition of the sexual abuse and its personal consequences.Conclusions the findings stress the importance of contextual factors (such as perceptions of sexuality, community structures, and cultural norms) in how ultra-orthodox children experience abuse by authority figures in the community and its aftermath, with implications for successful prevention and intervention efforts.

Journal: Child abuse & neglect (2021)
Publication types: Journal Article
Forensic parameters and mutation analysis of 23 short tandem repeat (PowerPlex® Fusion System) loci in Fujian Han Chinese population.

Kinship testing based on genetic markers has valuable practical applications.Short tandem repeat polymorphisms (strps) can have large number of alleles, and become the dominant marker for kinship identification.However, the high mutation rates affect the identification accuracy.Thus, accurate investigation of the mutation rate of str loci in different populations is crucial for the reliability of phylogenetic relationships.In present study, forensic parameters and mutation rates (include 95% ci) of 23 short tandem repeats (str) loci (d3s1358, d1s1656, d2s441, d10s1248, d13s317, d16s539, d18s51, d2s1338, csf1po, th01, v wa, d21s11, d7s820, d5s818, tpox, d8s1179, d12s391, d19s433, fga, d22s1045, penta e, penta d and dys391) were investigated through power plex® fusion system in fujian han population.The high level of cdp (0.999999999999999999999999992) and cpe (0.999999993) indicated the panel was high efficiency in forensic dna identification and paternity testing.In mutation analysis, 43 mutation cases were found through 54,124 parent-child meiotic transfers.The observed mutation rates ranged from 0 (d3s1358, d1s1656, d13s317, th01, d19s433 and d22s1045) to 0.0025 (penta e and fga).The overall mutation rate across all loci was 0.0008 and the average mutation rate for the 23 loci was estimated to be 0.00078 per meiosis.The vast majority of mutations were single-step (88.4%) mutation and also include double-step (9.3%) and triple-step (2.3%) mutations.Paternal mutation rate was more common than maternal mutation rate with a ratio of 7.2:1.In addition, mutation rates indicated positive correlation (r = 0.633, p = 0.009) with the expected heterozygosity (he).

Journal: Legal medicine (Tokyo, Japan) (2019)
Publication types: Journal Article
Are People with Aphasia (PWA) Involved in the Creation of Quality of Life and Aphasia Impact-Related Questionnaires? A Scoping Review.

Quality of life (qo l) questionnaires are used to describe the impact of aphasia on stroke survivors' life.People with aphasia (pwa) are traditionally excluded from research, potentially leading to a mismatch between the factors chosen in the tools and the realistic needs of pwa.The purpose of this review was to determine the direct involvement of pwa in the creation of qo l and aphasia impact-related questionnaires (air-qs).Methods a scoping review methodology was conducted by an expert librarian and two independent reviewers on health sciences based on the preferred reporting items for systematic reviews and metanalyses extension for scoping reviews (prisma-sc r) protocol, through a literature search in five databases: medline complete, pub med, psych info, scopus, and google scholar.Search terms included 'stroke', 'people with aphasia', 'communication', 'well-being', and 'quality of life'.Results of 952 results, 20 studies met the eligibility criteria.Of these, only four air-qs studies (20%) were found reporting the direct involvement of pwa, while no qo l tools did so.Evidence showed involvement in the creation phase of air-q, mainly in a consultation role.Conclusions there is an absence of a framework for conducting and reporting the involvement of pwa in qualitative participatory research studies, which limits effectiveness to promote equitable best practice in aphasia rehabilitation.

Journal: Brain sciences (2020)
Publication types: Journal Article;Review