syedzayyan/paper_mill_benchmark huggingface dataset:
Impact of an electronic health record alert on inappropriate prescribing of high-risk medications to patients with concurrent "do not give" orders.

To evaluate the effectiveness of clinical decision support (cds) alerts tied to high-risk medications at a michigan health system by determining the true prescriber action rate in response to select "do not give" (dng) alerts.Methods a retrospective review of prescriber actions in response to cds alerts was conducted to evaluate the effectiveness of alerts designed to prevent prescribing of high-risk medications to patients with concurrent dng orders.The primary endpoint was the overall action rate, determined by totaling orders cancelled within the alert display and orders modified shortly after an alert.The overall action rate was hypothesized to significantly exceed the action rate estimated on the basis of alert overrides alone.Following the initial review, changes were made to the alert format and preset documentation choices ("acknowledgement comments"), and it was hypothesized that these changes would increase the overall action rate.A repeat analysis was conducted to evaluate the impact of these changes.Results across a total of 506 cds alerts over 14 months, 78% resulted in prescribers modifying orders to comply with alert recommendations.Prescribers cancelled orders in response to only 26% of alerts, often overriding alerts prior to modifying orders.Documentation of rationale or approval for overrides was inconsistent, and while requiring acknowledgement comments facilitated documentation of prescriber rationale, it did not consistently improve overall action rates.Conclusion these findings demonstrate that override rates alone are not good markers for the true effectiveness of cds alerts and support the need for frequent evaluation of alerts at the institutional level.Cds alerts remain a valuable tool to prevent inappropriate prescribing of high-risk medications and for promoting patient safety.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists (2022)
Publication types: Journal Article
Results of a Surface Roughness Comparison between Stylus Instruments and Confocal Microscopes.

This article presents the results of an lmm-r-2019 interlaboratory comparison.Such comparisons of different families of measuring instruments are one of the activities conducted among the calibration laboratories to maintain their iso 17025 accreditation.Given that the study of surface roughness is becoming increasingly important in the field of dimensional metrology, the comparison focused on determining the ra parameter on a pseudorandom metallic roughness standard using two types of measuring instruments: physical contact (stylus instruments) and optical (confocal microscopes).Among the aspects studied was whether the roughness measurements obtained using calibrated confocal microscopes could be compared with those using traditional methods since optical instruments obtain measurements more quickly and responsively than do stylus instruments.The results showed that roughness measurements using confocal microscopes are comparable with those from a traditional stylus instrument.

Journal: Materials (Basel, Switzerland) (2022)
Publication types: Journal Article
Baicalin attenuates XRCC1-mediated DNA repair to enhance the sensitivity of lung cancer cells to cisplatin.

Baicalin plays important roles in different types of cancer.A previous report showed that baicalin attenuates cisplatin resistance in lung cancer.However, its mechanism remains unclear.In this study, we investigated the effect and mechanism of baicalin on dna repair and sensitivity of lung cancer cells to cisplatin.A549 and a549/dpp cells were treated with baicalin and cisplatin.A549/dpp cells were transfected with xrcc1 and si xrcc1.Cell viability and dna damage were detected by mtt and comet assay.Apoptosis rate and cell cycle were detected by flow cytometry assay.The expressions of bax, bcl-2, and cyclin d1 were detected by western blot.Xrcc1 expression was detected by reverse transcription quantitative polymerase chain reaction (rt-q pcr) and western blot.Baicalin and cisplatin decreased cell viability in a549 and a549/dpp cells in dose-dependent manner.Baicalin enhanced the effect of cisplatin on promoting apoptosis, arresting cell on s stage and triggering dna damage accompanied with the upregulation of bcl-2-associated x protein (bax) and downregulation of b-cell lymphoma 2 (bcl-2) and cyclin d1 in a549/dpp cells.Moreover, baicalin promoted the inhibitory effect of cisplatin on xrcc1 expression in a549 and a549/dpp cells.However, the synthetic effects of baicalin and cisplatin on a549/dpp cells were partially inhibited by xrcc1 overexpression and promoted by xrcc1 knockdown.This study demonstrates that baicalin interferes with xrcc1-mediated cellar dna repair to sensitize lung cancer cells to cisplatin.

Journal: Journal of receptor and signal transduction research (2022)
Publication types: Journal Article
SonoGames: sounds of the right kind introducing gamification into radiology training.

Radiology as compared to other fields of medicine has lagged, in incorporating modern training modalities such as gamification and simulation into its teaching curriculum.Objective this study aims to evaluate effectiveness of simulation-based teaching in collaboration with gamification.Bandura's conception of self-efficacy was used to provide qualitative assessment of participants' learning process through training event.Modified competitive game-based teaching methodology was utilized in an experimental study conducted for radiology residents.Workshop was divided into two sessions, first being three interactive didactic lectures followed by three competitive rounds.All participants were required to fill pre and post-self-efficacy questionnaire along with an activity evaluation form.Results significant self-efficacy scores were calculated for simulation-based stations of knowledge assessment and hands-on stations.Whereas significant association was also found between gender and knowledge assessment in communication skill (0.054), professionalism (0.004), and general knowledge (0.018).Similarly, noteworthy correlation was found between gender and all hands-on skills.In conclusion, study reported an overall increase in knowledge of post-test scores compared to pre-test scores due to use of gamification in combination with simulation-based teaching which shows a positive role in clinical training.However, further consideration is needed to improve process of integrating simulation in clinical training of participants.

Journal: BMC research notes (2021)
Publication types: Journal Article
Left lateral flank approach for spaying in cats.

Spaying is considered a reliable surgical method for birth control and preventing potential feline reproductive diseases.Aim this experiment was carried out to evaluate the suitability of the left lateral flank approach for routine spaying in cats.Methods twenty-seven queens of 7-24 months old and 1.5-3.5 kg body weight (bw) were spayed through flank laparotomy on the left lateral side of the abdomen.The cats were categorized into two groups: group a (n= 12; cats did not yet give birth) and group b (n= 15; cats gave birth before).The studied variables included age, bw, vaccination history, skin incision length, total surgical duration, the time needed for ligating ovarian pedicles and uterine body, suture materials, postoperative complications, and healing duration.Results there were no significant differences (p< 0.05) in age, bw, and vaccination history of the cats between the two groups.The mean incision length and total duration of surgery were greater in the case of group b than in group a.The ease of entering into the peritoneal cavity, duration of ligating the ovarian pedicles, and transfixing the uterine body did not vary significantly (p< 0.05) between the groups although a longer time was taken for group b than group a.62.96% spayed cats were found with no postoperative complication.The observed complications included wound site infection (7.41%), dehiscence of suture lines (11.11%), bleeding (3.70%), and oozing (14.82%) from wounds which were further treated successfully for complete recovery.Conclusion left lateral flank approach can be an effective method of spaying in queens without any life-threatening complications.

Journal: Open veterinary journal (2022)
Publication types: Journal Article
Association between depressive symptoms and subsequent injuries in early adolescents: a population-based study.

S depressive symptoms (dss) may be frequent and highly increase the risk of injuries in early adolescents (10-16 years).This study assessed the association between dss and subsequent school and out-of-school injuries in early adolescents.Methods the study population included 1219 middle-school adolescents from north-eastern france (mean age =12.7 ± 1.3) who completed at the end of school-year a questionnaire gathering socioeconomic features (nationality, family structure, parents' occupation, parents' education, and family income), obesity, alcohol use, tobacco use, health status, dss (kandel scale higher than the median value, hence including moderate levels), and school and out-of-school injuries during the present school-year.Were only considered the dss and confounders that had started before the school-year.Data was analyzed using multinomial logistic regression models.Results dss were strongly associated with one or more school-physical/sports-training injuries (sex-age-adjusted odds ratio orsa 2.08,p< 0.001), other-school-training injuries (orsa 2.13,p< 0.01), school-free-time injuries (orsa 2.84,p< 0.001), out-of-school-sports injuries (orsa 1.95,p< 0.001), and traffic injuries (orsa 3.78,p< 0.001).The risk was higher for having two or more injury categories (orsa 4.03,p< 0.001) than for only one injury category (orsa 1.80,p< 0.001).These results were robust and remained after further adjustment for socioeconomic features, obesity, alcohol use, tobacco use, and health status.Conclusions dss strongly increase the injury risk in early adolescents.Injury prevention should include dss screening and monitoring and help adolescents and their neighborhood be aware of the risk.highlights injuries and depressive symptoms (dss) are frequent in early adolescents.dss highly predict subsequent school and out-of-school injuries and cumulating several injury types.these results are robust after adjustment for socioeconomic features, being obese, alcohol use, tobacco use and poor health status.injury prevention should include early dss screening and monitoring and help adolescents and their neighborhood be aware of the risk.

Journal: Nordic journal of psychiatry (2021)
Publication types: Journal Article
Early Numeracy and Literacy Skills Among Monolingual and Bilingual Kindergarten Children.

Early numeracy and literacy skills are all the knowledge that children acquire spontaneously and independently before entering school and beginning formal learning.This knowledge is essential and forms the basis for the acquisition of reading and arithmetic in school.A bilingual child is a child who is fluent in two languages, as opposed to a monolingual child who is exposed to only one language.Bilingualism has been found to affect verbal and mathematical abilities in children, but only a few studies have focused on the early numeracy and literacy skills of preschoolers.This study examined the connection between early numeracy and literacy skills and among monolingual children as compared to bilingual children in preschool.Three hundred and two children aged 5-6years old were recruited from 74 kindergartens.Participants were divided into two groups: 151 monolingual children who spoke and were exposed to only one language (hebrew) and 151 bilingual children who spoke and were exposed to two languages (the bilingual children spoke different languages).Monolingual children performed better than the bilingual children in most of the literacy tasks, except for phonological awareness, in which no differences were found between the groups.In addition, in the early numeracy tasks, a difference was found only in the task, which included linguistic knowledge, number knowledge, and counting tasks, in which the monolingual children performed better.Furthermore, stronger correlations were found between the early numeracy and literacy skills among the monolingual group compared to the bilingual group.The study findings stress the importance of strengthening linguistic abilities, such as vocabulary expansion in kindergarten among populations in which more than one language is spoken.Supporting these abilities can reduce the gap between bilingual children and their monolingual classmates before entering school.

Journal: Frontiers in psychology (2021)
Publication types: Journal Article
Proposing a surgical algorithm for graduated orbital decompression in patients with Graves' orbitopathy.

To determine the outcome after orbital decompression using a graduated technique, adapting the surgical technique according to individual patients' disease characteristics.Methods we retrospectively examined the postoperative outcome in patients treated with a graduated balanced orbital decompression regarding reduction of proptosis, new onset diplopia and improvement in visual function.542 patients (1018 orbits) were treated between 2012 and 2020 and included in the study.Clinical examinations including visual acuity, exophthalmometry (hertel) and orthoptic evaluation were performed preoperatively and at minimum 6 weeks postoperatively.Mean follow-up was 22.9 weeks.Results mean proptosis values have significantly decreased after surgery (p < 0.01).In 83.3% of the patients hertel measurement normalized (≤ 18 mm) after surgery, new onset diplopia within 20° of primary position occurred in 33.0% of patients, of whom 16.0% had preoperative double vision in secondary gaze.Patients suffering from dysthyroid optic neuropathy (don) had a significant increase in visual acuity (p < 0.01).Conclusion we demonstrated that individually adapted graduated orbital decompression successfully improves key disease parameters of graves' orbitopathy with low morbidity.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2022)
Publication types: Journal Article
Commentary for an article on spin trapping of superoxide and hydroxyl radical: Practical aspect.

This commentary describes a highly cited paper by eli finkelstein, gerald m.Rosen, and elmer j.Raukman that appeared in archives of biochemistry and biophysics published in 1980.They reviewed many reports being regularly appearing in the literature describing spin trapping and hydroxyl radicals from various sources and contributed to the development and progress that has been made in oxidative stress research.

Journal: Archives of biochemistry and biophysics (2022)
Publication types: Journal Article;Review
Tisagenlecleucel in pediatric and young adult patients with Down syndrome-associated relapsed/refractory acute lymphoblastic leukemia.

Down syndrome-associated acute lymphoblastic leukemia (ds-all) patients suffer risk of chemotherapy-associated toxicities and poor outcomes.We evaluated tisagenlecleucel in 16 patients with ds-all in two phase 2 trials (eliana [nct02435849], ensign [nct02228096]) and a phase 3b, managed access protocol (b2001x [nct03123939]).Patients were 5-22 years old, had a median of two prior lines of therapy (range, 1-4), and four (25%) had prior stem cell transplants.Fourteen of 16 patients (88%) achieved complete remission (cr) or cr with incomplete blood count recovery (cri); 12 of 14 (86%) with cr/cri were minimal residual disease-negative.With a median follow-up of 13.2 months (range, 0.5-49.3 months), six patients (43%) relapsed after cr (three, cd19-negative; three, unknown) between 80-721 days post-infusion.Ongoing remissions in nine patients ranged from 6-48 months.Any-grade and grade 3/4 aes occurred in 16 and 14 patients, respectively; 44% experienced grade 3/4 cytokine release syndrome and 13% experienced grade 3/4 neurological events.Grade 3/4 prolonged cytopenias occurred in 44% of patients.No grade 3/4 infections were observed.Tisagenlecleucel expansion and long-term persistence were consistent with previous reports.Comparable to all patients without ds, tisagenlecleucel produced high remission rates, manageable side-effects, and promising long-term outcomes in pediatric/young adult patients with ds-all.

Journal: Leukemia (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Who is more likely to adopt and comply with the electronic patient-reported outcome measure (ePROM) mobile application? A real-world study with cancer patients undergoing active treatment.

This study aims to identify factors associated with the adoption and compliance of electronic patient-reported outcome measure (e prom) use among cancer patients in a real-world setting.Methods this prospective cohort study was conducted at the samsung medical center in seoul, korea, from september 2018 to january 2019.Cancer patients aged 18 years or older who owned smartphones and who were receiving chemotherapy or radiation therapy were eligible for this study.Patients were asked to use the app to report their symptoms every 7 days for a total of 21 days (3 weeks).Logistic regression was performed to identify the factors associated with the adoption and compliance.Results among 580 patients, 417 (71.9%) adopted the e prom app and 159 (27.4%) out of 417 had good compliance.Patients who had greater expectations regarding the ease of use (adjusted odds ratio [a or] 2.67, 95% ci: 1.28-5.57) and usefulness (a or 1.69, 95% ci: 1.05-2.72) of the e prom app were more likely to adopt the app than those who did not.Patients who had greater satisfaction with usefulness (a or 1.89, 95% ci 1.10-3.25) were more likely to comply with using the app, but satisfaction with ease of use was not related to the compliance.Conclusion while expectation regarding the ease of use and usefulness of the e prom app was associated with the adoption of the app, satisfaction with ease of use was not related to compliance with the e prom app.Satisfaction with usefulness was associated with the compliance of e prom app use.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2022)
Publication types: Journal Article
All-Aqueous Freeform Fabrication of Perfusable Self-Standing Soft Compartments.

Compartmentalized structures obtained in all-aqueous settings have shown promising properties as cell encapsulation devices, as well as reactors for trans-membrane chemical reactions.While most approaches focus on the preparation of spherical devices, advances on the production of complex architectures have been enabled by the interfacial stability conferred by emulsion systems, namely mild aqueous two-phase systems (atps), or non-equilibrated analogues.However, the application of non-spherical structures has mostly been reported while keeping the fabricated materials at a stable interface, limiting the free-standing character, mobility and transposition of the obtained structures to different setups.Here, the fabrication of self-standing, malleable and perfusable tubular systems through all-aqueous interfacial assembly is shown, culminating in the preparation of independent objects with stability and homogeneity after disruption of the polymer-based aqueous separating system.Those hollow structures can be fabricated with a variety of widths, and rapidly printed as long structures at flow rates of 15 mm s-1.The materials are used as compartments for cell culture, showcasing high cytocompatibility, and can be tailored to promote cell adhesion.Such structures may find application in fields that benefit from freeform tubular structures, including the biomedical field with, for example, cell encapsulation, and benchtop preparation of microfluidic devices.

Journal: Advanced materials (Deerfield Beach, Fla.) (2022)
Publication types: Journal Article
Hereditary thrombotic thrombocytopenic purpura and COVID-19: Impacts of vaccination and infection in this rare disease.

Introduction severe covid-19 is associated with an important increase of von willebrand factor and mild lowering of adamts13 activity that may, in the presence of a strong inflammatory reaction, increase the risk of acute thrombotic thrombocytopenic purpura (ttp).Although acute episodes of immune-mediated ttp associated with covid-19 or sars-co v-2 vaccination have been reported, data about clinical evolution of hereditary ttp (h ttp) during the pandemic are scarce.Method we conducted a survey among adult patients of the international hereditary ttp registry about sars-co v-2 vaccination, covid-19, and occurrence of acute h ttp episodes.Results of 122 adult h ttp patients invited to participate, 86 (70.5%) responded.Sixty-five had been vaccinated (75.6%), of which 14 had received in addition a booster, resulting in 139 individual vaccine shots.Although vaccinations in patients on plasma prophylaxis were done within 1 week of the last plasma infusion, all 23 patients treated with plasma on demand were vaccinated without prior plasma infusions.One patient on uninterrupted weekly plasma infusions presented within 3 days from his second vaccination with neurological symptoms and computed tomography scan 9 days later showed subacute ischemic/hemorrhagic frontal lobe infarction.A second male patient developed acute myocarditis after his second dose of m rna-1273 vaccine.Twelve (14%) patients had covid-19, associated with an acute h ttp episode in three of them: one patient had a transient ischemic attack, one a stroke, and a pregnant woman was hospitalized to intensify plasma treatment.Discussion the risk of an acute episode triggered by covid-19 seems higher than following vaccination in h ttp patients, who can be safely vaccinated against sars-co v-2.

Journal: Research and practice in thrombosis and haemostasis (2022)
Publication types: Journal Article
Employment and family caregiving in palliative care: An international qualitative study.

Family caregivers provide the majority of palliative care.The impact of family caregiving on employment and finances has received little research attention in the field of palliative care.Aim the aim of this study was to explore perspectives and experiences of combining paid employment with palliative care family caregiving, and to assess the availability and suitability of employment support across three countries - the united kingdom (uk), aotearoa new zealand and canada.Design a qualitative descriptive study design was used.Semi-structured interviews were held with 30 key informants with professional or personal experience in palliative care from the uk (n= 15), aotearoa new zealand (n= 6) and canada (n= 9).Interviews were recorded, transcribed and analysed using the principles of thematic analysis.Results four main themes were identified: (1) significant changes to working practices are required to enable end of life family carers to remain in work; (2) the negative consequences of combining caregiving and employment are significant, for both patient and carer; (3) employer support for working end of life caregivers is crucial but variable and; (4) national, federal and government benefits for working end of life family carers are necessary.Conclusion supporting carers to retain employment whilst providing care has potential benefits for the patient at end of life, the caregiver, and the wider economy and labour market.Employers, policymakers and governments have a role to play in developing and implementing policies to support working carers to remain in employment.

Journal: Palliative medicine (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't