syedzayyan/paper_mill_benchmark huggingface dataset:
Effect of methomyl on water quality, growth performance and antioxidant system in liver of GIFT (Oreochromis niloticus) in the presence of peppermint (Mentha haplocalyxBriq.) as a floating bed.

This study was conducted to investigate the effect of methomyl (met) on water quality, growth and antioxidant system of genetically improved farmed tilapia (gift,oreochromis niloticus) in the presence of peppermint as a floating bed.The concentration of nh3-n, no2--n, no3--n and tp in t3(with 200 g wet peppermint) was significantly lower (p< 0.05) than that in t2(100 g), t1(50 g) and control, and the nutrient removal rates were 61.90%, 31.59%, 59.86% and 45.92% in 20 days, respectively.Juveniles gift (5.1 ± 0.2 g) were exposed to sub-lethal concentrations of 0.2, 2.0, 20 and 200 μg/l of met for 45 days.After 6 weeks of a feeding trial, percentage weight gain (pwg), specific growth rate (sgr) and feed conversion ratio (fcr) were significantly decreased in 0.2, 2.0, 20 μg/l met groups respectively and increased in the 200 μg/l met group.Compared with the control, no significant changes in superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx) were detected in the 0.2 μg/l group.The significant increase in activities of sod, cat and gpx was accompanied by a diminution in reduced glutathione (gsh) levels resulting with tilapia exposed to 2.0, 20, or 200 μg/l for 45 days.The highest rates observed in sod, cat, gpx were 157.63%, 164.05% and 167.46% of the control respectively, and the lowest inhibition rate in gsh was 66.42% of the control.Peppermint as a floating bed can alleviate the adverse effects of met, such as growth retardation and oxidative stress.

Journal: Science progress (2022)
Publication types: Journal Article
Translational Development of a Silk-Elastinlike Protein Polymer Embolic for Transcatheter Arterial Embolization.

Locally blocking blood flow to tumors with embolic materials is the key to transcatheter arterial embolization for treating hepatocellular carcinoma.Current microparticle agents do not deeply penetrate target tissues and are compatible with a very limited selection of therapeutic agents.Silk-elastinlike protein polymers (selps) combine the solubility of elastin and the strength of silk to create an easily injected liquid embolic that transition into a solid depot amenable to loading with drugs, gene therapy agents, or biologics.Selp, injected as liquid solution, penetrates the vasculature before transitioning to a solid hydrogel.The objective of this manuscript is to evaluate selp embolization, stability, and biocompatibility at 7-, 30-, and 90-day survival intervals in a porcine model.Selp embolics selectively block blood flow in the kidneys and livers, with no off-target infarctions.As assessed with angiography, selp renal embolization exhibits decreasing persistence for the duration of the 90-day study period.There is an increased presence of microscopic selp emboli in the renal setting, compared to embosphere.Histologically scored inflammatory reactions to selp are decreased in both the renal and hepatic implantations compared to embosphere.In conclusion, a bioresorbable selp liquid embolic system deeply penetrates target tissue and selectively embolizes blood vessels in vivo.

Journal: Macromolecular bioscience (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, U.S. Gov't, Non-P.H.S.
Differences in access to virtual and in-person primary care by race/ethnicity and community social vulnerability among adults diagnosed with COVID-19 in a large, multi-state health system.

Research exploring telehealth expansion during the covid-19 pandemic has demonstrated that groups disproportionately impacted by covid-19 also experience worse access to telehealth.However, this research has been cross-sectional or short in duration; geographically limited; has not accounted for pre-existing access disparities; and has not examined covid-19 patients.We examined virtual primary care use by race/ethnicity and community social vulnerability among adults diagnosed with covid-19 in a large, multi-state health system.We also assessed use of in-person primary care to understand whether disparities in virtual access may have been offset by improved in-person access.Methods using a cohort design, electronic health records, and centers for disease control and prevention social vulnerability index, we compared changes in virtual and in-person primary care use by race/ethnicity and community social vulnerability in the year before and after covid-19 diagnosis.Our study population included 11,326 adult patients diagnosed with covid-19 between march and july 2020.We estimated logistic regression models to examine likelihood of primary care use.In all regression models we computed robust standard errors; in adjusted models we controlled for demographic and health characteristics of patients.Results in a patient population of primarily hispanic/latino and non-hispanic white individuals, and in which over half lived in socially vulnerable areas, likelihood of virtual primary care use increased from the year before to the year after covid-19 diagnosis (3.6 to 10.3%); while in-person use remained stable (21.0 to 20.7%).In unadjusted and adjusted regression models, compared with white patients, hispanic/latino and other race/ethnicity patients were significantly less likely to use virtual care before and after covid-19 diagnosis; hispanic/latino, native hawaiian/pacific islander, and other race/ethnicity patients, and patients living in socially vulnerable areas were also significantly less likely to use in-person care during these time periods.Conclusions newly expanded virtual primary care has not equitably benefited individuals from racialized groups diagnosed with covid-19, and virtual access disparities have not been offset by improved in-person access.Health systems should employ evidence-based strategies to equitably provide care, including representative provider networks; targeted, empowering outreach; co-developed culturally and linguistically appropriate tools and technologies; and provision of enabling resources and services.

Journal: BMC health services research (2022)
Publication types: Journal Article
Classification of three types of ginseng samples based on ginsenoside profiles: appropriate data normalization improves the efficiency of multivariate analysis.

It is well known that ginsenosides are the main active ingredients in ginseng, and they have also been important indexes for assessing the quality of ginseng.However, the absolute contents of ginsenosides in ginseng were shown to be varied with the origin, cultivated type, cultivated year and climate.It is a great challenge to distinguish the commercial types of ginsengs according to the content of one or several ginsenosides.Methods the common commercial types of ginsengs are white ginseng (wg), red ginseng (rg), american ginseng (ag).To clearly illustrate the differences among wg, rg and ag at the ginsenosides level, we established a strategy for the detection and identification of ginsenosides based on an optimized lc-q-orbitrap ms/ms method coupled with an in-house database of ginsenosides.Before and after the normalization, the ginsenosides datasheet was analyzed and compared using several state-of-the-art multivariate statistical analysis methods.Results here, 81 ginsenosides were identified in different ginseng samples.The majority of the ginsenosides (59 in 81) were all shared by wg, rg and ag.When the shared ginsenosides datasheet was normalized by the level of ginsenoside ro, our analysis strategy clearly divided the ginseng samples into three groups (i.e., wg, rg and ag groups).We found that the ginsenoside profiles in rg and wg were significantly different from those in ag.The potential markers and multivariate diagnostic models differentiating the three types of ginsengs were also indicated.Conclusion our novel methodology based on ginsenoside profiles is more robust than existing methods, and data normalization is required to improve the efficiency of multivariate statistical analysis.

Journal: Heliyon (2022)
Publication types: Journal Article
Enhanced physicochemical stability of ω-3 PUFAs concentrates-loaded nanoliposomes decorated by chitosan/gelatin blend coatings.

To enhance the physicochemical stability of ω-3 pufas concentrates from fish oil, biopolymer coating based on chitosan (ch) and gelatin (ge) deposited on the surface of nanoliposomes (nls) has been synthesized and characterized.The mean particle size of surface-decorated nanoliposomes (sdnls) containing ω-3 pufas concentrates was found to be in the range of 209.5-454.3 nm.Scanning and transmission electron microscopy revealed the spherical shape and smooth surface of the nanovesicles.Fourier-transform infrared spectroscopy and x-ray diffraction observations confirmed that the nls have been successfully coated by biopolymeric blends.The highest entrapment efficiency of 81.6% was obtained in polymer-stabilized nls with a concentration ratio of 0.3:0.1 (ch:ge).Differential scanning calorimetry results revealed enhanced thermal stability of vesicles after polymeric blend desorption.Finally, the oxidative stability assays demonstrated that the ω-3 pufas concentrates entrapped in sdnls was protected against oxidation in comparison to the free ω-3 pufas concentrates.

Journal: Food chemistry (2021)
Publication types: Journal Article
Safety and efficacy of GammaTile intracranial brachytherapy implanted during awake craniotomy.

Introduction gamma tile intracranial brachytherapy (cesium-131 seeds) has demonstrated encouraging safety and local control results, and recently received food and drug administration clearance for newly diagnosed and recurrent brain tumors.The authors present the first reported case of gamma tile intraoperative brachytherapy performed during an awake craniotomy.Methods a 50-year-old man had a biopsy-proven, 2.8 cm left lateral frontal glioblastoma lesion nearing broca's area on mri.Despite several interventions (craniotomy, adjuvant chemoradiation, tumor treating fields) tumor progression occurred near the left parietal resection cavity.Re-resection was planned with awake craniotomy and language mapping.A preoperative planning session involving radiation oncology and neurosurgery identified the area of the expected postoperative bed, and consequently five gamma tiles were ordered, each containing 4 cesium-131 3.5 u seeds.Results during surgery, tumor mapping and bipolar stimulation were performed while the patient spoke in complete sentences.Speech arrest occurred upon stimulation at the posterior edge of the gyrus, indicative of language cortex.Microsurgical maximal safe resection subsequently occurred, and areas at risk for residual/recurrence disease were determined in consultation with radiation oncology.Subsequently, neurosurgery placed all five gamma tiles (20 cesium-131 seeds total) after which closure was completed and radioactive surveys of the room remained within state statue.Postoperative dosimetry yielded excellent coverage.Conclusions the first reported case of gamma tile intraoperative brachytherapy during awake craniotomy supports the safety and feasibility of this treatment strategy.This case indicates that for patients with tumors adjacent to eloquent cortex, awake craniotomy can allow for custom implantation of intraoperative brachytherapy following maximum safe resection.

Journal: Brachytherapy (2021)
Publication types: Case Reports;Journal Article
Bidirectional Lithiophilic Gradients Modification of Ultralight 3D Carbon Nanofiber Host for Stable Lithium Metal Anode.

Using 3d host is an effective way to solve the dendrite growth problem and accommodate volume changes of lithium (li) metal anode.However, the preferred li deposition on the top surface leads to the li metal agglomeration at the surface.In addition, the large weight of the 3d host also greatly decreases the capacity based on the whole anode.Herein, a bidirectional lithiophilic gradient modification, including a top-down zn o gradient and a bottom-up sn gradient, is applied to an ultralight 3d carbon nanofiber host (density: 0.1 g cm-3) and ensures the evenly filling lithium deposition in the 3d host.Zn o transforms into highly ionic conductive li-zn alloy and li2o during cycling, enhancing the li-ion transportation from top to bottom.The metallic sn also lowers the li nucleation potential, guiding the preferential li deposition from the bottom.With such a host, a stable ce of 97.5% over 100 cycles at 1 m a cm-2and 3 m ah cm-2is achieved, and the full battery also delivers good cycling stability over 300 cycles with a high ce of 99.8% coupled with high loading li fe po4cathode (10 mg cm-2) and low n/p ratio (≈3).

Journal: Small (Weinheim an der Bergstrasse, Germany) (2022)
Publication types: Journal Article
Small-scale variability in a mosaic tropical rainforest influences habitat use of long-tailed macaques.

Pristine habitats have generally been considered to be the most important ecological resource for wildlife conservation, but due to forest degradation caused by human activities, mosaics of secondary forests have become increasingly prominent.We studied three forest types in a mosaic tropical forest consisting of short secondary forest (ss), tall secondary forest (ts) and freshwater swamp forest (sf).These forests differed in stand structure and floristic composition, as well as phenological productivity of fruits, flowers and young leaves.We examined habitat use of long-tailed macaques (macaca fascicularis) in relation to indices of phenological activity.The macaques used the ss for feeding/foraging more than the ts and the sf.This was because the ss had higher productivity of fruit, which is a preferred food resource for macaques.Stem densities of young leaves in the ss and the ts also influenced habitat use, as they provided more clumped resources.Use of sf was limited, but these forests provided more species-rich resources.Our results showed that m.Fascicularis responded to small-scale variability in phenological activity between forest types found in a heterogeneous mosaic forest, with young secondary regrowth forests likely providing the most important food resources.Mosaic landscapes may be important as they can buffer the effects of temporal food resource variability in any given forest type.In our increasingly human-altered landscapes, a better understanding of the role of secondary forest mosaics is crucial to the conservation and management of wildlife habitats and the animals they support.

Journal: Primates; journal of primatology (2018)
Publication types: Journal Article
Relationships Among Belief in God, Well-Being, and Social Capital in the 2020 European and World Values Surveys: Distinguishing Interpersonal and Ideological Prosociality.

Analyses of the 2020 combined european and world values surveys (124,958 respondents from 77 countries) found that people who believed in god tended to be happier, more satisfied with lives, and healthier than non-believers.Believers trusted people close to them (e.g., neighbors) more than non-believers, although non-believers tended to trust people in general and trust people from other countries more than believers.Non-believers tended to be more ideologically prosocial than non-believers (e.g., belonging to an environmental organization, advocating freedom of speech vs.Control).Such differences were stronger in countries in which there were more vs fewer believers.Moreover, these differences remained after controlling for individual differences in sex, age, education, income, and left-right political orientation.

Journal: Journal of religion and health (2022)
Publication types: Journal Article
The Tinel Sign and Myelinated Axons in the Cross-Face Nerve Graft: Predictors of Smile Reanimation Outcome for Free Gracilis Muscle Transfer?

Introduction:during a two-stage free gracilis muscle transfer (fgmt) to restore smile to patients with facial paralysis, some surgeons assess nerve regeneration through the cross-face nerve graft (cfng) with the tinel sign and a nerve biopsy.objective:to test whether ultimate smile reanimation outcomes are correlated with (1) the tinel sign or (2) myelinated axons of the biopsied cfng at the time of fgmt.methods:retrospective case series was performed at a tertiary care facial nerve center.Dynamic smile outcomes were quantified with emotrics analysis of pre- and postoperative photographs.results:of the 113 fgmt surgeries by cfng performed since 2002, 92 patients had pre- and postoperative photo-documentation.Most patients (89%,n= 82) had a positive tinel sign at the time of fgmt; however, 14 patients with positive tinel signs were deemed failures.Interestingly, 4 patients with a negative tinel sign went on to have successful dynamic outcomes and 16 patients lacking myelinated axons in their cfng biopsy ultimately achieved successful smile outcomes.conclusion:although the majority of patients had a positive tinel sign and myelinated axons in the cfng at the time of fgmt, the presence or absence of either factor did not predict ultimate smile outcome in this series.

Journal: Facial plastic surgery & aesthetic medicine (2022)
Publication types: Journal Article
Potential and challenges for an integrated management of tuberculosis, diabetes mellitus, and hypertension: A scoping review protocol.

In many low- and middle-income countries (lmics), the epidemiological transition is characterized by an increased burden of non-communicable diseases (ncds) and the persistent challenge of infectious diseases.The transmission of tuberculosis, one of the leading infectious diseases, can be halted through active screening of risk groups and early case findings.Studies have reported comorbidities between tuberculosis (tb) and ncds, which necessitates the development of an integrated disease management model.This scoping review discusses the possibilities and problems of integration in managing tb and ncds, with a particular emphasis on diabetic mellitus (dm) and hypertension screening and control.We will conduct this review following arksey and o'malley's framework for scoping review.We will use key terms related to integrated management, i.e., screening, diagnosis, treatment, and care, of tb, dm, and hypertension in pub med, scopus database, and science direct for research published from january 2005 to july 2021.This review will also consider grey literature, including unpublished literature and international disease management guidelines on tb, dm, and hypertension from who or other health professional organization.We will export the search results to citation manager software (end note).We will remove duplicates and apply the inclusion and exclusion criteria to identify the set of papers for the review.After screening the titles and abstract, two authors will independently review the full text of selected studies and extract the data.We will synthesize all selected studies qualitatively and the results will be discussed with the experts.The results will be used as the basis of the development of a guideline for integrated tb, dm, and hypertension management.

Journal: PloS one (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Operative Treatments for Reflux After Bariatric Surgery: Current and Emerging Management Options.

Gastroesophageal reflux disease (gerd) is a common disorder that has a well-established connection with obesity.To ameliorate the morbidity associated with obesity, bariatric procedures have become an established pathway to accomplish sustained weight loss.In some procedures, such as with the roux-en-y gastric bypass surgery, weight loss is also accompanied by the resolution of gerd symptoms.However, other popular bariatric surgeries, such as the sleeve gastrectomy, have a controversial impact on their effect on reflux.Consequently, increased attention has been given to the development of strategies for the management of de novo or recurrent reflux after bariatric surgery.This article aims to discuss medical and surgical strategies for reflux after bariatric surgery, and their outcomes.

Journal: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (2017)
Publication types: Journal Article;Review
A Modified Power-on Programming Method after Deep Brain Stimulation for Parkinson Disease.

To explore the feasibility of using a modified power-on programming method in deep brain stimulation (dbs) for parkinson disease (pd).Methods we conducted a retrospective cohort study including 151 pd patients with bilateral robot-assisted dbs surgery from july 2017 to june 2020.Ninety-seven patients were adopted to the modified power-on programming method (group i) and 54 patients were adopted to the traditional power-on programming method (group ii).In one-year follow-up, power-on programming duration, stimulation parameters, scores of unified pd rating scale (updrs) and updrs-iii of the 2 groups were recorded and compared.Results there were no significant differences in the postoperative updrs, updrs-iii improvement rate, and stimulation parameters between the 2 groups.The duration of power-on programming of group i (1.7 ± 1.1 hours) was significantly less than that of group ii (3.5 ± 1.8 hours, p < 0.0001).Conclusions the modified power-on programming method can achieve a similar clinical effect to the traditional method, with the advantage of more efficiency.

Journal: World neurosurgery (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Control of the Induced Handedness of Helical Nanofilaments Employing Cholesteric Liquid Crystal Fields.

In this paper, a simple and powerful method to control the induced handedness of helical nanofilaments (hnfs) is presented.The nanofilaments are formed by achiral bent-core liquid crystal molecules employing a cholesteric liquid crystal field obtained by doping a rod-like nematogen with a chiral dopant.Homochiral helical nanofilaments are formed in the nanophase-separated helical nanofilament/cholesteric phase from a mixture with a cholesteric phase.This cholesteric phase forms at a temperature higher than the temperature at which the helical nanofilament in a bent-core molecule appears.Under such conditions, the cholesteric liquid crystal field acts as a driving force in the nucleation of hnfs, realizing a perfectly homochiral domain consisting of identical helical nanofilament handedness.

Journal: Molecules (Basel, Switzerland) (2021)
Publication types: Journal Article
Genotype-Phenotype Association in ABCA4-Associated Retinopathy.

Stargardt disease (stgd1) is the most common inherited retina degeneration.It is caused by biallelic abca4 variants, and no treatment is available to date.Stgd1 shows marked phenotypic variability, especially regarding the age of onset.The underlying genotype can partially explain this variability.Notably, a subset of abca4 variants was previously associated with an earlier disease onset than truncating abca4 variants, pointing toward pathogenic mechanisms beyond the loss of gene function in these patients.On the other end of the spectrum, variants such as p.gly1961glu were associated with markedly slower extrafoveal disease progression.Given that these drastic differences in phenotype are based on genotype (resulting in important prognostic implications for patients), this chapter reviews previous approaches to genotype-phenotype correlation analyses in stgd1.

Journal: Advances in experimental medicine and biology (2023)
Publication types: Journal Article
Literature search: Simple rules for confronting theunknown.

Literature search forms the foundation of most clinical decisions about patient management and is the starting point for all bedside/bench-side research.Despite being an essential tool in the armamentarium of all medical professionals and researchers, literature search remains a challenge, often resulting in frustration and waste of time (and resources).This article aims to provide a beginner's guide to information seekers for a step-wise approach to literature search on web-based databases.

Journal: Medical journal, Armed Forces India (2022)
Publication types: Journal Article;Review