syedzayyan/paper_mill_benchmark huggingface dataset:
The Dose-Related Efficacy of Acupuncture on Endometrial Receptivity in Infertile Women: A Systematic Review and Meta-Analysis.

Progress has been achieved by using acupuncture widely for poor endometrial receptivity (per).However, different acupuncture dosages may lead to controversy over efficacy.Objective to evaluate the evidence-based conclusions of dose-related acupuncture on infertile women with per.Method references were retrieved from nine databases from inception to 26 february 2022.This meta-analysis included randomized controlled trials (rcts) that investigated the dose-related efficacy of acupuncture for per with outcomes of endometrium receptivity (er) parameters by transvaginal sonography (tvs) and the subsequent pregnancy outcomes in three acupuncture-dose groups: the high-dosage group (three menstrual cycles), the moderate-dosage group (one menstrual cycle), and the low-dosage group (two or four days).Since there remained sufficient heterogeneity among the three subsets, we prespecified seven subgroup variables (four clinical and three methodological) to investigate the heterogeneities.Results a total of 14 rcts (1,564 women) of moderate or low overall quality were included.The results were different when the dosage of acupuncture was restricted.For the moderate or high-dosage group, cpr and part of er parameters were improved in the acupuncture group (i.e., cpr: or = 2.00, 95% ci [1.24, 3.22],p= 0.004,i2= 0% in one menstrual cycle; or = 2.49, 95%ci [1.67, 3.72],p< 0.05,i2= 0% in three menstrual cycles).However, for the low-dosage group, no statistical difference was observed in cpr (or = 0.07, 95% ci [-0.10, 0.23],p= 0.44,i2= 82%) and a part of the er parameters.In subgroup analysis, four subgroup variables (the routine treatment, risk of performance bias, duration of acupuncture treatment, and the age of participants) could explain some of the heterogeneities across all trials.Conclusion the finding indicated that the trend of relatively more acupuncture dosage showed better effects for poor endometrial receptivity among per women.It remains a potential heterogeneity in our studies.Further high-quality trials with a homogeneity trial design need to be conducted.

Journal: Frontiers in public health (2022)
Publication types: Meta-Analysis;Systematic Review;Research Support, Non-U.S. Gov't;Journal Article
Pulsed Magnetic Stimulation for Stress Urinary Incontinence and Its Impact on Sexuality and Health.

It is becoming increasingly common that patients' preferences move towards non-surgical approaches, such as pulsed magnetic stimulation, for female stress urinary incontinence.Objective we evaluated the efficacy and safety of a device that uses electromagnetic technology to treat urinary incontinence, with an emphasis on health-related quality of life.Methods a total of 47 female subjects from 18 to 80 years old were enrolled.After block randomization, treatment consisted of 2 pulsed planar magnetic stimulation sessions per week for 4 weeks (8 sessions).Validated questionnaires: female sexual function index, international consultation on incontinence questionnaire for urinary incontinence: short form, and pelvic floor bothersome.Follow-ups were performed at weeks 1, 9, and 14.Results the present study is one of the first clinical trials published evaluating the efficacy and safety of the electromagnetism-based device with flat configuration in patients with stress urinary incontinence, showing a reduction in pfbq, icqsf, and oxford test scores during follow-up, and significantly at week 14 of follow-up, which implied a favorable impact on clinical outcomes, quality of life, and sexuality.Conclusions the improved results in the treatment group compared with the simulated group show that pulsed magnetic stimulation is a safe and attractive non-invasive alternative for patients who prefer non-surgical treatments.

Journal: Medicina (Kaunas, Lithuania) (2022)
Publication types: Journal Article
Cluster-ID-Based Throughput Improvement in Cognitive Radio Networks for 5G and Beyond-5G IoT Applications.

Cognitive radio (cr), which is a common form of wireless communication, consists of a transceiver that is intelligently capable of detecting which communication channels are available to use and which are not.After this detection process, the transceiver avoids the occupied channels while simultaneously moving into the empty ones.Hence, spectrum shortage and underutilization are key problems that the cr can be proposed to address.In order to obtain a good idea of the spectrum usage in the area where the crs are located, cooperative spectrum sensing (css) can be used.Hence, the primary objective of this research work is to increase the realizable throughput via the cluster-based cooperative spectrum sensing (cbcss) algorithm.The proposed scheme is anticipated to acquire advanced achievable throughput for 5g and beyond-5g internet of things (io t) applications.Performance parameters, such as achievable throughput, the average number of clusters and energy, have been analyzed for the proposed cbcss and compared with optimal algorithms.

Journal: Micromachines (2022)
Publication types: Journal Article
Diversity and Long-Term Dynamics of Human Blood Anelloviruses.

Anelloviruses (avs) are commensal members of the human blood virome.Even though it was estimated that over 90% of the human population carries avs, the dynamics of the av virome ("anellome") are unknown.We investigated the dynamics of blood anellomes in two healthy people followed up for more than 30 years.Both subjects were positive for avs in the majority of samples.alphatorquevirus(torque teno virus [ttv]) was the most common genus in both subjects, followed by betatorquevirus(torque teno minivirus [ttmv]) and gammatorquevirus(torque teno midivirus [ttmdv]).Almost five times more lineages were found in subject 1 than in subject 2, and the anellomes differed phylogenetically.Both anellomes remained compositionally stable, and 9 out of 64 av lineages were detected in over half of the time points.We confirmed the long-term and short-term persistence of 13 lineages by specific quantitative pcr (q pcr).Av lineages were detected in blood for over 30 years.Noticeable differences in anellome richness were found between the tested subjects, but both anellomes remained compositionally stable over time.These findings demonstrate that the human blood anellome is personal and that av infection is chronic and potentially commensal.importanceknowledge of the persistence of avs in humans is crucial to our understanding of the nature of av infection (chronic or acute) and the role of av in the host.We therefore investigated the dynamics of anellovirus infection in two healthy people followed up for 30 years.Our findings suggest that the human blood anellovirus virome (anellome) remains stable and personal for decades.

Journal: Journal of virology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Using Interpretable Machine Learning to Identify Baseline Predictive Factors of Remission and Drug Durability in Crohn's Disease Patients on Ustekinumab.

Ustekinumab has shown efficacy in crohn's disease (cd) patients.To identify patient profiles of those who benefit the most from this treatment would help to position this drug in the therapeutic paradigm of cd and generate hypotheses for future trials.The objective of this analysis was to determine whether baseline patient characteristics are predictive of remission and the drug durability of ustekinumab, and whether its positioning with respect to prior use of biologics has a significant effect after correcting for disease severity and phenotype at baseline using interpretable machine learning.Patients' data from sustain, a retrospective multicenter single-arm cohort study, were used.Disease phenotype, baseline laboratory data, and prior treatment characteristics were documented.Clinical remission was defined as the harvey bradshaw index ≤ 4 and was tracked longitudinally.Drug durability was defined as the time until a patient discontinued treatment.A total of 439 participants from 60 centers were included and a total of 20 baseline covariates considered.Less exposure to previous biologics had a positive effect on remission, even after controlling for baseline disease severity using a non-linear, additive, multivariable model.Additionally, age, body mass index, and fecal calprotectin at baseline were found to be statistically significant as independent negative risk factors for both remission and drug survival, with further risk factors identified for remission.

Journal: Journal of clinical medicine (2022)
Publication types: Journal Article
Neural Stem Cell-Derived Exosomal Netrin1 Contributes to Neuron Differentiation of Mesenchymal Stem Cells in Therapy of Spinal Bifida Aperta.

Spinal bifida aperta (sba) is a congenital malformation with a high incidence.Bone marrow mesenchymal stem cell (bmsc) transplantation has the potential to repair the structure of damaged tissues and restore their functions.This is an optional treatment that can be used as a supplement to surgery in the treatment of sba.However, the application of bmscs is limited, as the neuronal differentiation rate of bmscs is not satisfactory when used in treating severe sba.Thus, we aimed to assess the effect of neural stem cell (nsc)-derived exosomes on bmsc neuronal differentiation and observe the therapeutic effect in an ex vivo rat sba embryo model.We found that nsc-derived exosomes increased the neuronal differentiation rate of bmscs in vitro and in the sba embryo model ex vivo.Proteomic analysis showed that nsc-derived exosomes were enriched in netrin1, which positively regulated neuronal differentiation.Netrin1 increased the neuronal differentiation rate of bmscs and nscs and upregulated the expression of the neuronal markers, microtubule-associated protein (map2), neurofilament, and β3-tubulin.Bioinformatic analysis revealed that netrin1 treatment increased the expression of the transcription factors hand2 and phox2b, related to neuronal differentiation.Furthermore, the netrin1-induced nsc neuronal differentiation was significantly blocked by phox2b knockdown.We suggest that nsc-derived exosomal netrin1 induces neuronal differentiation via the hand2/phox2b axis by upregulating the expression of hand2 and phox2b.Therefore, nsc-derived exosomes are a critical inducer of bmsc neuronal differentiation and represent a potential treatment agent that can benefit bmsc treatment in sba.

Journal: Stem cells translational medicine (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Social Determinants and COVID-19 in a Community Health Center Cohort.

Associations between social determinants of health (sdoh), demographic factors including preferred language, and sars-co v-2 detection are not clear.We conducted a retrospective cohort study among those seeking testing for sars-co v-2 at a multi-site, urban community health center.Logistic regression and exact matching methods were used to identify independent predictors of sars-co v-2 detection among demographic, sdoh, and neighborhood-level variables.Of 1,361 included individuals, sars-co v-2 was detected among 266 (19.5%).Logistic regression demonstrated that sars-co v-2 detection was less likely in white participants relative to hispanic participants (adjusted odds ratio [a or] 0.18, 95% confidence interval [ci] 0.05-0.46).And more likely in patients who prefer spanish relative to those that prefer english (a or 2.04, 95% ci 1.43-2.96).No observed sdoh predicted sars-co v-2 detection in adjusted models.A robustness analysis using a matched subset of the study sample produced findings similar to those in the main analysis.Preferring to receive care in spanish is an independent predictor of sars-co v-2 detection in a community health center cohort.

Journal: Journal of immigrant and minority health (2022)
Publication types: Journal Article
Clinicopathological significance of SOX4 and epithelial-mesenchymal transition markers in patients with laryngeal squamous cell carcinoma.

And aim sex-determining region-y-related high-mobility-group box 4 (sox4) is associated with the metastasis and prognosis of many cancer types.However, studies on the role of sox4 in laryngeal squamous cell carcinoma (lscc) are few, and hence the mechanism is unclear.Epithelial-mesenchymal transition (emt) allows neoplastic cells to gain the plasticity and motility required for tumor progression and metastasis.This study aimed to analyze the relationship between sox4 and emt, and their relationship with clinicopathological factors and related prognosis.Methods immunohistochemical staining was used to detect the positive expression of sox4 protein, emt-related transcription factor protein, and related marker protein in 127 lscc tissue samples.At the same time, data on various parameters of clinical pathology and postoperative survival were collected.Results the positive expression rate of sox4 and slug in lscc was related to pathological differentiation, lymphatic invasion, and pathological tumor node metastasis (tnm) of a tumor.The expression rates of zeb1, twist, e-cadherin, n-cadherin, and β-catenin in lscc correlated with lymphatic invasion and pathological tumor node metastasis.The expression of sox4, combined expression of sox4 and zeb1, and lymphatic invasion were independent prognostic factors for the total survival time of patients with lscc.Conclusions in summary, sox4 was vital in the lscc emt process, which might be mediated by transcription factor zeb1.Sox4 and zeb1 might serve as potential biomarkers of metastasis and prognosis, as well as promising therapeutic targets of lscc.

Journal: Medicine (2021)
Publication types: Journal Article
Current State of Non-surgical Devices for Female Stress Urinary Incontinence.

Of review the purpose of this review is to summarize and assess the current non-surgical devices for the treatment of stress urinary incontinence (sui).Recent findings devices for sui can generally be divided into two categories.One category is the augmentation of pelvic floor muscle training (pfmt), wherein devices such as vaginal cones, intravaginal biofeedback, and electrical or magnetic stimulation are used to strength the pelvic floor musculature, though none are more effective than traditional pfmt.The second category of devices mechanically occludes the outlet and includes incontinence pessaries, intravaginal occlusion devices, and urethral plugs and patches.While these are palliative rather than curative, they share similar rates of improvement in leakage.A number of novel devices exist for the treatment and management of sui.Though no single device has been shown to be more effective than pfmt alone, they may be beneficial for women who have difficulty isolating their pelvic floor muscles, desire accountability, or prefer technology-based engagement.Outlet occlusion devices are less comfortable for the patient, but remain an option for women who do not desire surgery.

Journal: Current urology reports (2022)
Publication types: Journal Article;Review
Renal agenesis associated with contralateral ectopic ureter and hydroureteronephrosis.

Congenital anomalies of the kidney and the urinary tract such as renal agenesis and ectopic ureter have complex development.These anomalies have variable presentations and associations.In this report, we highlight the case of a young man with congenital renal agenesis presenting for a urinary tract infection.Abdominal and pelvic computed tomography imaging revealed the rare association of renal agenesis with contralateral ectopic ureter and subsequent hydroureteronephrosis.A urinary tract infection can be the presenting complication of such association, and a long follow-up is needed to anticipate the management.

Journal: Radiology case reports (2021)
Publication types: Case Reports;Journal Article
Evaluation of the diagnostic management of deep vein thrombosis in the emergency department of a tertiary hospital in Santa Catarina, Brazil: a cross-sectional study.

Venous thromboembolism is an entity that encompasses both deep vein thrombosis and pulmonary thromboembolism.Although protocols for the diagnosis of these diseases are well defined, there is evidence of inappropriate use of diagnostic resources.Objectives to define the epidemiological profiles of patients admitted to the emergency department with suspected deep vein thrombosis, to determine rates of inappropriate ordering of d-dimer assays and color venous doppler echocardiography of the lower limbs, and to identify whether these requests followed the recommendations contained in the 2015 brazilian society of angiology and vascular surgery guidelines.Methods we conducted a cross-sectional observational study that retrospectively evaluated 168 patients with suspected deep vein thrombosis for whom d-dimer assays were requested.The most common risk factors were measured and the pretest probability was calculated with the wells score.The epidemiological profile of these patients and the rates of inappropriate d-dimer testing were assessed using descriptive statistics.Results the d-dimer requests were inadequate in 55 (32.7%) patients.Venous color doppler ultrasound was used to examine the lower limbs of 14 (8.3%) of the patients with a low probability according to the wells score and a negative d-dimer result.No additional diagnostic methods were used in 19 (11.3%) of those with a low probability according to the wells score and a high d-dimer result.There was unnecessary use of cdus in 35 (20.8%) cases.The overall rate of inappropriate workup was 53.5%.Conclusions differences were found between clinical practice and the recommendations for diagnostic evaluation of patients with suspected deep vein thrombosis, with inappropriate use of diagnostic tests.

Journal: Jornal vascular brasileiro (2022)
Publication types: Journal Article
Conservative interventions and clinical outcome measures used in the perioperative rehabilitation of breast cancer patients undergoing mastectomy: a scoping review.

Mastectomy is the first-line treatment approach for more than 90% of breast cancer patients.The numerous physical impairments associated with this surgical procedure negatively impact the patient's quality of life.To date, rehabilitation resources available for breast cancer patients undergoing mastectomy within the institutions affiliated to the centre intégré universitaire de soins de santé et de services sociaux de la mauricie-et-du-centre-du-québec (ciusss-mcq) are lacking and do not always seem to reflect the particularities of breast cancer care pathways.The purpose of this review was to identify and describe the conservative interventions and the clinical outcome measures used in the perioperative physical rehabilitation of women with breast cancer who are awaiting or have undergone mastectomy.We also aimed to report on the barriers and facilitators to study participation and completion.Methods medline, cinahl, and the cochrane library were searched from inception to january 2021, and we updated the search on july 11, 2022.We included peer-reviewed english and french literature with quantitative designs, describing conservative interventions and clinical outcome measures used within rehabilitation programs designed for women who were awaiting or had undergone mastectomy.Paired reviewers independently reviewed all citations and articles using a two-phase screening process and independently extracted the data.Results of the 6080 articles identified, 57 met the inclusion criteria.Most interventions were multimodal, which combined exercise with patient education, manual therapy, and/or lymphatic drainage.The most frequently used objective measures of physical function were shoulder range of motion, muscle strength, and signs of lymphedema.In contrast, the primary patient-reported outcome measures were quality of life, shoulder function, and pain.Undergoing another breast surgery, death, and cancer recurrence were the most reported barriers to study completion.Conclusion this scoping review reports on the heterogeneity and wide range of conservative interventions and clinical outcome measures used in the physical rehabilitation of breast cancer patients who had undergone or were scheduled to undergo mastectomy.Tailoring interventions to breast cancer patients' needs and promoting outpatient rehabilitation interventions appear to be better suited to the particularities of breast cancer care pathways.Further research is needed to better identify barriers and facilitators to study participation and completion.

Journal: BMC women's health (2022)
Publication types: Journal Article;Review
Urolithin A Promotes Angiogenesis and Tissue Regeneration in a Full-Thickness Cutaneous Wound Model.

The treatment of chronic wound is an important topic of current clinical issue.Neovascularization plays a crucial role in skin wound healing by delivering fresh nutrients and oxygen to the wound area.The aim of this study was to investigate the mechanisms of urolithin a (ua) in angiogenesis during wound healing.The results ofin vitroexperiments showed that treatment with ua (5-20 μm) promoted the proliferation, migration, and angiogenic capacity of huvecs.Furthermore, we investigated the effect of uain vivousing a full-thickness skin wound model.Subsequently, we found that ua promoted the regeneration of new blood vessels, which is consistent with the results of accelerated angiogenesisin vitroexperiments.After ua treatment, the blood vessels in the wound are rapidly formed, and the deposition and remodeling process of the collagen matrix is also accelerated, which ultimately promotes the effective wound healing.Mechanistic studies have shown that ua promotes angiogenesis by inhibiting the pi3k/akt pathway.Our study provides evidence that ua can promote angiogenesis and skin regeneration in chronic wounds, especially ischemic wounds.

Journal: Frontiers in pharmacology (2022)
Publication types: Journal Article
Genome instability is associated with ethnic differences between Asians and Europeans in hepatocellular carcinoma.

Hepatocellular carcinoma (hcc) is one of the deadliest cancer types with diverse etiological factors across the world.Although large scale genomic studies have been conducted in different countries, integrative analysis of hcc genomes and ethnic comparison across cohorts are lacking.methods:we first integrated genomes of 1,349 hcc patients from five large cohorts across the world and applied multiple statistical methods in identifying driver genes.Subsequently, we systematically compared hcc genomes and transcriptomes between asians and europeans using the tcga cohort.results:we identified 29 novel candidate driver genes, many of which are infrequent tumor suppressors driving late-stage tumor progression.When we systematically compared ethnic differences in the genomic landscape between asian and european hccs using the tcga cohort (n = 348), we found little differences in driver frequencies.Through multi-modal integrative analysis, we found higher genomic instability in asians together with a collection of molecular events ranging from tumor mutation burden (tmb), copy number alterations as well as transcriptomic subtypes segregating distinctively between two ethnic backgrounds.Strikingly, we identified an asian specific transcriptomic subtype with multiple ethnically enriched genomic alterations, in particular chromosome 16 deletion, leading to a clinically aggressive rna subgroup unique to asians.Integrating multi-modal information, we found that survival models predict patient prognosis much better in asians than in europeans, demonstrating a higher potential for precision medicine applications in asia.conclusion:for the first time, we have uncovered an unprecedented amount of genomic differences segregating distinctively across ethnicities in hcc and highlighted the importance of differential disease biology and management in hcc across ethnic backgrounds.

Journal: Theranostics (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't