syedzayyan/paper_mill_benchmark huggingface dataset:
Factors associated with elevated low-density lipoprotein cholesterol levels among hill tribe people aged 30 years and over in Thailand: a cross-sectional study.

Low-density lipoprotein cholesterol (ldl-c) is one of the most important types of cholesterol and has an impact on health.Certain lifestyle and dietary habits in different populations may leads to increased levels of ldl-c, particularly among those with poor education and economic statuses, such as hill tribe people in thailand.This study aimed to estimate the prevalence of and determine the factors associated with high ldl-c levels among hill tribe people in northern thailand.Methods a cross-sectional study was performed to gather information from six main hill tribe populations: akha, lahu, hmong, yao, karen, and lisu.Individuals who were aged over 30 years and living in 30 selected hill tribe villages were invited to participate in the study.A validated questionnaire and 5-m l blood specimens were used to obtain data.Correlation analyses, chi-square tests, t-tests, and logistic regression were used to detect correlations and associations.Results a total of 2552 participants were recruited into the study; 65.9% were females, and 64.1% were aged younger than 60 years old.Approximately 69.6% of participants had abnormal ldl-c levels; 33.6% had above-optimal levels, 24.3% had borderline high levels, 8.0% had high levels, and 3.7% had very high levels.A total of 17.4% of participants had low high-density lipoprotein cholesterol (hdl-c) and high ldl-c levels, while 14.9% had high triglyceride and ldl-c levels.After controlling for sex, age, religion, education, annual family income, and marital status in the multivariate model, three variables were found to be associated with high ldl-c levels: occupation, the amount of lard used in daily cooking, and glycated hemoglobin (hb a1c).Those who were working as agriculturalists had a 1.34-fold greater chance of having abnormal ldl-c than traders and others (95% ci = 1.09-1.34).Those who used moderate and high quantities of lard in their daily cooking had a 1.45-fold (95% ci = 1.15-1.82) and 1.31-fold (95% ci = 1.04-1.68) greater likelihood of having abnormal ldl-c levels than those who used low quantities, respectively.Those who had abnormal hb a1c levels were less likely to develop abnormal ldl-c levels than those who had normal hb a1c levels (aor = 0.69, 95% ci = 0.51-92).Conclusions effective public health programs that do not conflict with the cultures of hill tribes are urgently needed, particularly programs encouraging the use of small quantities of lard for daily cooking practices.

Journal: BMC public health (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Antifungal susceptibility profile and molecular identification of Cyp51C mutations in clinical and environmental isolates of Aspergillus flavus from Argentina.

The emergence of azole resistance in non-fumigatus aspergillus strains is on the raise.Objectives to study the susceptibility profiles and the molecular mechanisms of azole resistance of environmental and clinical strains of aspergillus flavus from argentina.Methods thirty-five a flavus isolates (18 from soybean seeds and chickpea seeds and 17 from the clinic) were analysed for amphotericin b and azole resistance using the standard microbroth dilution method according to clsi m38-a2 guidelines.Sequencing analysis of the cyp51 genes was conducted in those isolates displaying high mics values to itraconazole, voriconazole and/or posaconazole.Results among the environmental isolates, 33.3% of them showed high mic values for at least one triazole whereas 23.5% of the clinical isolates displayed high mic values for amphotericin b.Point mutations in the cyp51c gene were recorded in most environmental isolates with non-wild-type mic values.Conclusions susceptibility differences among environmental a flavus isolates might suggest the possibility of native resistance to certain triazole antifungals used in the clinic.To the best of our knowledge, this is the first report of antifungal screening of environmental strains of a flavus in soybean seeds and chickpea seeds from argentina that showed increased resistance to voriconazole and itraconazole in comparison to clinical strains.

Journal: Mycoses (2021)
Publication types: Journal Article
ERα promotes transcription of tumor suppressor geneApoA-Iby establishing H3K27ac-enriched chromatin microenvironment in breast cancer cells.

Apolipoprotein a-i (apo a-i), the main protein component of high-density lipoprotein (hdl), plays a pivotal role in reverse cholesterol transport (rct).Previous studies indicated a reduction of serum apo a-i levels in various types of cancer, suggesting apo a-i as a potential cancer biomarker.Herein, ectopically overexpressed apo a-i in mda-mb-231 breast cancer cells was observed to have antitumor effects, inhibiting cell proliferation and migration.Subsequent studies on the mechanism of expression regulation revealed that estradiol (e2)/estrogen receptor α (erα) signaling activates apo a-igene transcription in breast cancer cells.Mechanistically, our ch ip-seq data showed that erα directly binds to the estrogen response element (ere) site within the apo a-igene and establishes an acetylation of histone 3 lysine 27 (h3k27ac)‍-enriched chromatin microenvironment.Conversely, fulvestrant (ici 182780) treatment blocked erα binding to ere within the apo a-igene and downregulated the h3k27ac level on the apo a-igene.Treatment with p300 inhibitor also significantly decreased the apo a-imessenger rna (m rna) level in mcf7 cells.Furthermore, the analysis of data from the cancer genome atlas (tcga) revealed a positive correlation between erα and apo a-iexpression in breast cancer tissues.Taken together, our study not only revealed the antitumor potential of apo a-i at the cellular level, but also found that erα promotes the transcription of apo a-igene through direct genomic effects, and p300 may act as a co-activator of erα in this process.

Journal: Journal of Zhejiang University. Science. B (2021)
Publication types: Journal Article
Mediolateral episiotomy and risk of obstetric anal sphincter injuries and adverse neonatal outcomes during operative vaginal delivery in nulliparous women: a propensity-score analysis.

The potential protective effect of mediolateral episiotomy for obstetrical anal sphincter injuries (oasis) remains controversial during operative vaginal delivery because of the difficulties to take into account the risk factors and clinical conditions at delivery; in addition, little is known about the potential benefits of mediolateral episiotomy on neonatal outcomes.The objectives were to investigate the associations between mediolateral episiotomy and both oasis and neonatal outcomes, using propensity scores.Methods we performed a retrospective population-based observational study from a perinatal registry that includes all births in a french region between 2010 and 2017.All nulliparous women with singleton pregnancy delivering by operative vaginal deliveries at 37 weeks gestational age or later were included.Inverse-probability-of-treatment weighting with propensity scores was used to minimize indication bias.Oasis was defined as third and fourth-degree tears according to royal college of obstetricians and gynecologists.Two neonatal outcomes were studied: condition at birth (5-min apgar score less than 7 and/or umbilical artery p h less than 7.10), and admission to neonatal intensive care unit.Results the study population consisted of 7589 women; 2880 (38.0%) received mediolateral episiotomy.After applying propensity scores, episiotomy was associated with a lower rate of oasis in forceps/spatula delivery (2.3 vs 6.8%, risk ratio (rr) 0.38, 95% confidence interval (ci) 0.28-0.52) and in vacuum delivery (1.3 vs 3.4%, rr 0.27, 95% ci 0.20-0.38) as compared with no episiotomy.Mediolateral episiotomy was associated with better condition at birth in case of forceps/spatula delivery (4.5 vs 8.8%, rr 0.56, 95% ci 0.39-0.81).In cases of fetal distress (40.7%), mediolateral episiotomy was associated with better condition of infant at birth in women who delivered by forceps/spatula (4.2 vs 13.5%, rr 0.52, 95% ci 0.31-0.89).No association was found with neonatal unit admission (rr 0.93, 95% ci 0.50-1.74).Conclusions use of mediolateral episiotomy was associated with a lower rate of oasis during operative vaginal delivery, and in infants it was associated with better condition at birth following forceps/spatula delivery.

Journal: BMC pregnancy and childbirth (2022)
Publication types: Journal Article;Observational Study
The Decisive Role of Spin States and Spin Coupling in Dictating Selective O2Adsorption in Chromium(II) Metal-Organic Frameworks.

The coordinatively unsaturated chromium(ii)-based cr3[(cr4cl)3(btt)8]2(cr-btt; btt3-=1,3,5-benzenetristetrazolate) metal-organic framework (mof) has been shown to exhibit exceptional selectivity towards adsorption of o2over n2/h2.Using periodic density functional theory (dft) calculations, we attempted to decipher the origin of this puzzling selectivity.By computing and analyzing the magnetic exchange coupling, binding energies, the partial density of states (p dos), and adsorption isotherms for the pristine and gas-bound mofs [(cr4(x)4cl)3(btt)8]3-(x=o2, n2, and h2), we unequivocally established the role of spin states and spin coupling in controlling the gas selectivity.The computed geometries and gas adsorption isotherms are consistent with the earlier experiments.The binding of o2to the mof follows an electron-transfer mechanism resulting in a cr iiisuperoxo species (o2.-) with a very strong antiferromagnetic coupling between the two centers, whereas n2/h2are found to weakly interact with the metal center and hence only slightly perturb the associated coupling constants.Although the gas-bound and unbound mofs have an s=0 ground state (gs), the nature of spin the configurations and the associated magnetic exchanges are dramatically different.The binding energy and the number of oxygen molecules that can favorably bind to the cr center were found to vary with respect to the spin state, with a significant energy margin (47.6 k j mol-1).This study offers a hitherto unknown strategy of using spin state/spin couplings to control gas adsorption selectivity in mofs.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (2022)
Publication types: Journal Article
Defining genomic events involved in the evolutionary trajectories of myeloma and its precursor conditions.

All patients with a diagnosis of multiple myeloma (mm) have a preceding, asymptomatic expansion of clonal plasma cells, clinically recognized as monoclonal gammopathy of undetermined significance or smoldering multiple myeloma (smm).While most patients with monoclonal gammopathy of undetermined significance have a very small rate of progression, smm is a widely heterogeneous condition where a fraction of patients will progress to symptomatic mm rather quickly, while others will experience an indolent clinical course.The differentiation between progressive and stable precursor condition thus represents one of the most important unmet clinical needs in the mm community.The ability to identify patients at high-risk of progression before major clonal expansion and onset of end-organ damage would enable strategies for early prevention and perhaps more effective intervention.All proposed criteria to predict the progression of myeloma precursor conditions are built around indirect markers of disease burden and, therefore, are generally able to accurately identify only a small fraction of patients in whom progression to mm is already occurring.Leveraging whole genome and exome sequencing, it has been shown that patients with stable myeloma precursor conditions are characterized by either absence or lower prevalence of distinct genomic events that are detectable in progressive precursor condition years before the progression.In this review, we discuss evolving genomic concepts and tools; and their ability to differentiate myeloma precursor conditions into two distinct entities: one benign (monoclonal gammopathy of benign significance) and another malignant (asymptomatic multiple myeloma).

Journal: Seminars in oncology (2022)
Publication types: Journal Article;Review;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Relevance of CSF, Serum and Neuroimaging Markers in CNS and PNS Manifestation in COVID-19: A Systematic Review of Case Report and Case Series.

The data on neurological manifestations in covid-19 patients has been rapidly increasing throughout the pandemic.However, data on cns and pns inflammatory disorders in covid-19 with respect to csf, serum and neuroimaging markers is still lacking.Methods we screened all articles resulting from a search of pub med, google scholar and scopus, using the keywords "sars-co v-2 and neurological complication", "sars-co v-2 and cns complication" and "sars-co v-2 and pns complication" looking for transverse myelitis, vasculitis, acute disseminated encephalomyelitis, acute hemorrhagic necrotizing encephalitis (ahne), cytotoxic lesion of the corpus callosum (clocc) and guillain-barré syndrome (gbs), published between 1 december 2019 to 15 july 2021.Results of the included 106 cns manifestations in our study, cns inflammatory disorders included transverse myelitis (17, 14.7%), ahne (12, 10.4%), adem (11, 9.5%), clocc/mers (10, 8.6%) and vasculitis (4, 3.4%).Others were nonspecific encephalopathy, encephalitis, seizures and stroke.Most patients were >50 years old (75, 70.8%) and male (64, 65.3%).Most (59, 63.4%) were severe cases of covid-19 and 18 (18%) patients died.Of the included 94 pns manifestations in our study, gbs (89, 92.7%) was the most common.Most of these patients were >50 years old (73, 77.7%) and male (59, 64.1%).Most (62, 67.4%) were non-severe cases of covid-19, and ten patients died.Conclusion our comprehensive review of the clinical and paraclinical findings in cns and pns manifestations of covid-19 provide insights on the pathophysiology of sars-co v-2 and its neurotropism.The higher frequency and severity of cns manifestations should be noted by physicians for increased vigilance in particular covid-19 cases.

Journal: Brain sciences (2021)
Publication types: Journal Article;Review
Between-hospital and between-surgeon variation in thresholds for hip and knee replacement.

Total hip replacement (thr) and total knee replacement (tkr) are cost-effective interventions to reduce pain and disability associated with osteoarthritis, however there is no clear guidelines available to determine appropriate patient selection and the timing of surgery.This prospective cohort study aimed to evaluate the hospital- and surgeon-level variation in the severity of patient-reported symptoms prior to thr and tkr.Methods patients undergoing primary thr (n = 4330) or tkr (n = 7054) for osteoarthritis who participated in a national registry-led patient reported outcome measures (proms) pilot program were included in the analysis.Pre-operative oxford hip score (ohs) and oxford knee score (oks) (range 0-48; representing worst to best hip/knee pain and function) data were examined for variation between private and public hospitals and between surgeons using linear mixed models.Results pre-operative mean ohs was significantly higher (better) in patients whose surgery was performed in a private hospital compared to public hospitals; 21.39 versus 18.11 (mean difference 3.27, 95% ci 1.75, 4.79).For oks, the difference between private hospital and public hospital scores was dependent on bmi and gender.Most of the variation in pre-operative ohs and oks was not at the individual hospital- or surgeon-level, which explained only a negligible proportion of the model variance (⟨5%) for thr and tkr.Conclusion apart from a difference between private and public hospitals, there was little between-hospital or between-surgeon symptom variation in joint-specific pain and function prior to thr or tkr.The findings suggest consistency in the surgical thresholds for patients being offered hip and knee joint replacement procedures.

Journal: ANZ journal of surgery (2022)
Publication types: Journal Article
Lipid-based nanocarriers for delivery of small interfering RNA for therapeutic use.

Small interfering rnas (si rnas) indicate the unprecedented versatility in silencing disease-causing genes.However, the therapeutic use of si rna is limited by its inherent instability in serum and immunogenicity.Thus, to realize their full therapeutic potential, there is a growing need to develop an efficient si rna delivery system that targets it towards the localized symptomatic sites.Consequently, nanosized lipid carriers have been utilized for the targeted delivery of therapeutic agents to improve their efficacy in clinical studies.In this review, we attempt to elaborate on the current improvements of chemically diverse lipid carriers for the delivery of si rnas-based drugs across a wide range of diseases.Finally, we discuss the patents and clinical status of si rna in lipid formulations, which continue to expand for years to come.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2020)
Publication types: Journal Article;Review
Nanostructured La0.75Sr0.25Cr0.5Mn0.5O3-Ce0.8Sm0.2O2Heterointerfaces as All-Ceramic Functional Layers for Solid Oxide Fuel Cell Applications.

The use of nanostructured interfaces and advanced functional materials opens up a new playground in the field of solid oxide fuel cells.In this work, we present two all-ceramic thin-film heterostructures based on samarium-doped ceria and lanthanum strontium chromite manganite as promising functional layers for electrode application.The films were fabricated by pulsed laser deposition as bilayers or self-assembled intermixed nanocomposites.The microstructural characterization confirmed the formation of dense, well-differentiated, phases and highlighted the presence of strong cation intermixing in the case of the nanocomposite.The electrochemical properties─solid/gas reactivity and in-plane conductivity─are strongly improved for both heterostructures with respect to the single-phase constituents under anodic conditions (up to fivefold decrease of area-specific resistance and 3 orders of magnitude increase of in-plane conductivity with respect to reference single-phase materials).A remarkable electrochemical activity was also observed for the nanocomposite under an oxidizing atmosphere, with no significant decrease in performance after 400 h of thermal aging.This work shows how the implementation of nanostructuring strategies not only can be used to tune the properties of functional films but also results in a synergistic enhancement of the electrochemical performance, surpassing the parent materials and opening the field for the fabrication of high-performance nanostructured functional layers for application in solid oxide fuel cells and symmetric systems.

Journal: ACS applied materials & interfaces (2022)
Publication types: Journal Article
Staying Strong with Schools: Testing an Elementary School-Based Intervention for Military-Connected Children.

To address the unique behavioral health challenges facing military-connected children (mcc) during parental deployment and reintegration, we developed a low-cost, low-burden school-based intervention, staying strong with schools (ssws).Ssws builds upon best educational practice by formalizing relationships between administrators, guidance staff, teachers, and parents to enhance social connection to support psychosocial functioning of mcc.We previously evaluated the feasibility and acceptability of the intervention in an open pilot with 2 elementary schools, finding high feasibility and high acceptability.A randomized controlled trial of 10 civilian elementary schools was conducted to examine the efficacy of ssws.Ten schools were randomly assigned to ssws versus an educational pamphlet waitlist control condition.Participants included 56 mcc, assessed on measures of behavioral and emotional functioning, perceived social support, and mental health symptoms at the beginning, middle, and end of school year.Over the course of the school year, parents in intervention schools reported their child exhibited less internalizing behavior than nonintervention school parents; there were no differences in parent report of child externalizing behavior.Children in ssws schools reported greater perceived social support than children in control schools.Findings from this small-scale randomized controlled trial suggest that ssws might be efficacious in supporting mcc in civilian elementary schools and support a larger scale implementation to test its efficacy further.

Journal: Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A study on how concurrent visual feedback affects motor learning of adjustability of grasping force in younger and older adults.

In this study, we investigated the differences of the effectiveness from concurrent visual feedback among younger and older adults in learning tasks that require adjustability of grasping force (agf), as well as the functions related to agf in each generation.The younger and older adult groups were evaluated for simple visual reaction time as visual-motor speed (vms) and a 100 g agf task that reflected the difference between desired performance and actual performance.The main learning task was then practiced using concurrent visual feedback and tested without feedback.The vms of older adults was slower than that of the younger, and the error in the 100 g agf task was larger in older adults than in the younger adults.Performance improved from pre-test to retention test in both groups, but the older adult group failed to reach the level of the younger adult group.The results of this study show that concurrent visual feedback is effective for learning the tasks that require agf in both groups.Indicatively, improvement in performance during practice is insufficient in older people for whom there is a large difference between desired performance and actual performance, or whose vms is slow.

Journal: Scientific reports (2022)
Publication types: Journal Article
Efficacy and Safety of Super-Selective Bronchial Arterial Infusion Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer.

The objective was to study the effectiveness and safety of super-selective bronchial arterial infusion (sbai) chemotherapy in the treatment of advanced stage non-small cell lung cancer (nsclc).Methods the clinical data of 120 advanced nsclc patients were retrospectively analyzed.Among them, 60 nsclc patients were treated with sbai method, another 60 nsclc patients received systemic intravenous chemotherapy as the control group.The efficacy and safety between two groups of patients were compared.Results the objective response rate and disease control rate of nsclc patients treated with sbai were significantly higher than those of the control group (p < 0.05).The 3-month progression-free survival (pfs) rate (96.67%) and 6-month pfs rate (86.67%) of the sbai group were significantly higher than those of the control group (73.33% and 56.67%) (p < 0.01).After treatment, the fact-l scores of patients in the sbai group were significantly higher than those of the control group (p < 0.05).The scores of all the 13 core symptom items and six symptom interference items of nsclc patients in the sbai group were lower than those of the control group (p < 0.05).The adverse reactions rate in the sbai group were significantly lower than those in the control group (p < 0.05).Conclusion the short-term efficacy of sbai chemotherapy for advanced nsclc is significantly higher than that of traditional peripheral intravenous chemotherapy, and it can significantly improve patients' quality of life and reduce the incidence of adverse reactions.

Journal: Chemotherapy (2022)
Publication types: Journal Article