syedzayyan/paper_mill_benchmark huggingface dataset:
The role of intravitreal ranubizumab in the treatment of familial exudative vitreoretinopathy of stage 2 or greater.

To evaluate the role of intravitreal ranubizumab (ivr) in the treatment of familial exudative vitreoretinopathy (fevr) of stage 2 or greater either as primary or an ajunct to conventional treatments.Methods retrospective, non-controlled clinical study.Thirty patients (37 eyes) diagnosed with fevr were enrolled.Twenty patients (66.67%) were male and 10 patients (33.33%) were female.Age ranged from 0.4 to 35 years old (median 3y).Ivr was used either as primary or as a combined therapy according to the retinal neovasuclar activities.The follow up ranged from 1 to 57mo with mean 16.73±15.73 (median 11)mo.The treatment effect of retinal neovasuclar activites were recorded as well as the ocular and systemic side effects.Results among 30 patients (37 eyes), 10 eyes received single ivr, 1 eye received 2 injections.Three eyes were treated with ivr and simutanous laser photocoagulation.Laser indirect ophthalmoscopy (lio) was applied in 5 eyes 1mo after the primary ivr.Seven eyes were treated surgically following the primary ivr due to persistent retinal neovasuclar activities and retinal traction.Ivr was used as combined treatment with vitrectomy in 11 eyes.Retinal neovascular regression was notified 1mo following the primary ivr in all eyes.Neither systemic nor ocular complications were recorded.Conclusion ivr may be an effective modality in the treatment of fevr either as primary or as an ajunct to the conventional therapies.The long term effect and safty of ivr still need further research.

Journal: International journal of ophthalmology (2018)
Publication types: Journal Article
Usefulness of Dapagliflozin for Nephrotic Syndrome Secondary to Diabetic Kidney Disease.

An 81-year-old woman with a medical history of type 2 diabetes mellitus and diabetic nephropathy was admitted with a diagnosis of multiple cerebellar infarctions.Proteinuria and leg edema were observed on the day after admission and diagnosed as nephrotic syndrome.Furosemide and spironolactone were started but showed no diuretic effect, and the renal function deteriorated.These agents were then replaced with dapagliflozin, which resulted in a positive diuretic effect and subsequent improvement of hypoalbuminemia and renal dysfunction.This case report demonstrates the utility of dapagliflozin for nephrotic syndrome to achieve a positive diuretic effect and improve hypoalbuminemia without deteriorating the renal function.

Journal: Internal medicine (Tokyo, Japan) (2022)
Publication types: Case Reports;Journal Article
Bioactive Low Molecular Weight Keratin Hydrolysates for Improving Skin Wound Healing.

Keratin biomaterials with high molecular weights were intensively investigated but few are marketed due to complex methods of extraction and preparation and limited understanding of their influence on cells behavior.In this context the aim of this research was to elucidate decisive molecular factors for skin homeostasis restoration induced by two low molecular weight keratin hydrolysates extracted and conditioned through a simple and green method.Two keratin hydrolysates with molecular weights of 3758 and 12,400 da were physico-chemically characterized and their structure was assessed by circular dichroism (cd) and ftir spectroscopy in view of bioactive potential identification.Other investigations were focused on several molecular factors: α1, α2 and β1 integrin mediated signals, cell cycle progression in pro-inflammatory conditions (tnfα/lps stimulated keratinocytes and fibroblasts) and icam-1/vcam-1 inhibition in human vascular endothelial cells.Flow cytometry techniques demonstrated a distinctive pattern of efficacy: keratin hydrolysates over-expressed α1 and α2 subunits, responsible for tight bounds between fibroblasts and collagen or laminin 1; both actives stimulated the epidermal turn-over and inhibited vcam over-expression in pro-inflammatory conditions associated with bacterial infections.Our results offer mechanistic insights in wound healing signaling factors modulated by the two low molecular weight keratin hydrolysates which still preserve bioactive secondary structure.

Journal: Polymers (2022)
Publication types: Journal Article
Anesthesia myTIPreport: A Web-Based Tool for Real-Time Evaluation of Accreditation Council for Graduate Medical Education's Milestone Competencies and Clinical Feedback to Residents.

Feedback in clinical education is essential but challenged by multiple barriers.This report describes the use of my tipreport, a web-based tool, which streamlines the dual purpose of milestone evaluation and real-time feedback from faculty to residents in a us anesthesiology program.In a 6-month trial, faculty members and residents used my tipreport for daily clinical feedback.We believe my tipreport will be a valuable tool for clinical feedback given further refinement of the tool and improved faculty and resident development on program use.

Journal: A&A practice (2019)
Publication types: Journal Article
Blood Transcriptomes of Anti-SARS-CoV-2 Antibody-Positive Healthy Individuals Who Experienced AsymptomaticVersusClinical Infection.

The reasons behind the clinical variability of sars-co v-2 infection, ranging from asymptomatic infection to lethal disease, are still unclear.We performed genome-wide transcriptional whole-blood rna sequencing, bioinformatics analysis and pcr validation to test the hypothesis that immune response-related gene signatures reflecting baseline may differ between healthy individuals, with an equally robust antibody response, who experienced an entirely asymptomatic (n=17)versusclinical sars-co v-2 infection (n=15) in the past months (mean of 14 weeks).Among 12.789 protein-coding genes analysed, we identified six and nine genes with significantly decreased or increased expression, respectively, in those with prior asymptomatic infection relatively to those with clinical infection.All six genes with decreased expression (ifit3, ifi44l, rsad2, folr3, pi3, alox15), are involved in innate immune response while the first two are interferon-induced proteins.Among genes with increased expression six are involved in immune response (gzmh, clec1b, clec12a), viral m rna translation (gcat), energy metabolism (cacna2d2) and oxidative stress response (enc1).Notably, 8/15 differentially expressed genes are regulated by interferons.Our results suggest that subtle differences at baseline expression of innate immunity-related genes may be associated with an asymptomatic disease course in sars-co v-2 infection.Whether a certain gene signature predicts, or not, those who will develop a more efficient immune response upon exposure to sars-co v-2, with implications for prioritization for vaccination, warrant further study.

Journal: Frontiers in immunology (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Rigidified Derivative of the Non-macrocyclic Ligand H4OCTAPA for Stable Lanthanide(III) Complexation.

The stability constants of lanthanide complexes with the potentially octadentate ligand chxoctapa4-, which contains a rigid 1,2-diaminocyclohexane scaffold functionalized with two acetate and two picolinate pendant arms, reveal the formation of stable complexes [log kla l= 17.82(1) and log kyb l= 19.65(1)].Luminescence studies on the eu3+and tb3+analogues evidenced rather high emission quantum yields of 3.4 and 11%, respectively.The emission lifetimes recorded in h2o and d2o solutions indicate the presence of a water molecule coordinated to the metal ion.1h nuclear magnetic relaxation dispersion profiles and17o nmr chemical shift and relaxation measurements point to a rather low water exchange rate of the coordinated water molecule (kex298= 1.58 × 106s-1) and relatively high relaxivities of 5.6 and 4.5 m m-1s-1at 20 mhz and 25 and 37 °c, respectively.Density functional theory calculations and analysis of the paramagnetic shifts induced by yb3+indicate that the complexes adopt an unprecedented cis geometry with the two picolinate groups situated on the same side of the coordination sphere.Dissociation kinetics experiments were conducted by investigating the exchange reactions of lu l occurring with cu2+.The results confirmed the beneficial effect of the rigid cyclohexyl group on the inertness of the lu3+complex.Complex dissociation occurs following proton- and metal-assisted pathways.The latter is relatively efficient at neutral p h, thanks to the formation of a heterodinuclear hydroxo complex.

Journal: Inorganic chemistry (2022)
Publication types: Journal Article
Preoperative evaluation of liver regeneration following hepatectomy in hepatocellular carcinoma using magnetic resonance elastography.

For patients with hepatocellular carcinoma (hcc) undergoing hepatectomy, insufficient remnant liver regenerative capacity can lead to liver failure.The aim of this study was to evaluate the potential role of magnetic resonance elastography (mre) for the preoperative prediction of liver regeneration in patients with hcc after partial hepatectomy (ph).Methods a total of 54 patients with hcc undergoing mre prior to ph were retrospectively included.The total functional liver, volume of preoperative future liver remnant (lvpre), and volume of postoperative liver remnant (lvpost), respectively, were measured, and the regeneration index (ri) and parenchymal hepatic resection rate (phrr) were manually calculated.Univariate and multivariate logistic regression analyses were conducted to identify factors associated with a high ri, and receiver operating characteristic (roc) curves were employed to evaluate the diagnostic performance of the liver stiffness (ls) values.Patients were classified into three subgroups based on the value of phrr: low phrr ( 50%).Subsequently, spearman correlation analysis was used to investigate the relationship between ls values and ri in the subgroups.Results multivariable analysis revealed a low ls value was associated with greater odds of a high ri [odds ratio (or), 0.049; 95% confidence interval (ci): 0.002 to 0.980].An optimal cutoff value of 3.30 k pa was used to divide all patients into a low ri group and a high ri group with an area under the curve (auc) value of 0.882 (95% ci: 0.767 to 0.996).A significant negative relationship between ri and ls values (r=-0.799; p<0.001) was observed in the intermediate phrr subgroup.Conclusions the ls values based on mre may serve as a potential preoperative predictor of liver regeneration for patients with hcc undergoing ph.

Journal: Quantitative imaging in medicine and surgery (2022)
Publication types: Journal Article
Evaluation of Epigenetic and Radiomodifying Effects during Radiotherapy Treatments in Zebrafish.

Radiotherapy is still a long way from personalizing cancer treatment plans, and its effectiveness depends on the radiosensitivity of tumor cells.Indeed, therapies that are efficient and successful for some patients may be relatively ineffective for others.Based on this, radiobiological research is focusing on the ability of some reagents to make cancer cells more responsive to ionizing radiation, as well as to protect the surrounding healthy tissues from possible side effects.In this scenario, zebrafish emerged as an effective model system to test for radiation modifiers that can potentially be used for radiotherapeutic purposes in humans.The adoption of this experimental organism is fully justified and supported by the high similarity between fish and humans in both their genome sequences and the effects provoked in them by ionizing radiation.This review aims to provide the literature state of the art of zebrafish in vivo model for radiobiological studies, particularly focusing on the epigenetic and radiomodifying effects produced during fish embryos' and larvae's exposure to radiotherapy treatments.

Journal: International journal of molecular sciences (2021)
Publication types: Journal Article;Review
New Napyradiomycin Analogues fromStreptomycessp. Strain CA-271078.

As part of our continuing efforts to discover new bioactive compounds from microbial sources, a reinvestigation of extracts of scaled-up cultures of the marine-derived streptomycessp.Strain ca-271078 resulted in the isolation and structural elucidation of four new napyradiomycins (1-3,5).The known napyradiomycin sc (4), whose structural details had not been previously described in detail, and another ten related known compounds (6-15).The structures of the new napyradiomycins were characterized by hrms and 1d- and 2d-nmr spectroscopies and their relative configurations were established through a combination of molecular modelling withn oeand coupling constants nmr analysis.The absolute configuration of each compound is also proposed based on biosynthetic arguments and the comparison of specific rotation data with those of related compounds.Among the new compounds,1was determined to be the first non-halogenated member of napyradiomycin a series containing a functionalized prenyl side chain, while2-4harbor in their structures the characteristic chloro-cyclohexane ring of the napyradiomycin b series.Remarkably, compound5displays an unprecedented 14-membered cyclic ether ring between the prenyl side chain and the chromophore, thus representing the first member of a new class of napyradiomycins that we have designated as napyradiomycin d1.Anti-infective and cytotoxic properties for all isolated compounds were evaluated against a set of pathogenic microorganisms and the hep g2 cell line, respectively.Among the new compounds, napyradiomycin d1 exhibited significant growth-inhibitory activity against methicillin-resistant staphylococcus aureus,mycobacterium tuberculosis, and hep g2.

Journal: Marine drugs (2019)
Publication types: Journal Article
Heterostructure engineering of iridium species on nickel/molybdenum nitride for highly-efficient anion exchange membrane water electrolyzer.

Developing highly active electrocatalysts is a pivotal issue for anion-exchange membrane water electrolyzers (aemwe).However, realizing the continuous hydrogen generation at a large current density remains challenging.Herein, a novel kind of hybrid electrode is successfully developed by introducing trace iridium (ir) species onto a hierarchical ni/mo5n6heterostructure on ni foam (ir-ni/mo5n6/nf).The synergistic advantages of high conductivity, abundant active sites, and strong electronic interaction endow superior reaction kinetics, presenting a highly-active bifunctional electrocatalyst.Remarkably, the ir-ni/mo5n6/nf exhibit extremely low overpotentials of 52 m v and 250 m v at 100 m a cm-2for hydrogen evolution reaction (her) and oxygen evolution reaction (oer).By exploiting the ir-ni/mo5n6as both anode/cathode, the constructed aemwe device delivers superior performance.The current density reaches 2.1 a cm-2at a voltage of 2.0 v and 250 m a cm-2at 1.8 v in alkaline/neutral media.This work put forward a facile and effective strategy to synthesize advanced bifunctional electrocatalysts for water electrolysis.

Journal: Journal of colloid and interface science (2022)
Publication types: Journal Article
Reversing electron transfer in a covalent triazine framework for efficient photocatalytic hydrogen evolution.

Covalent triazine-based frameworks (ctfs) have emerged as some of the most important materials for photocatalytic water splitting.However, development of ctf-based photocatalytic systems with non-platinum cocatalysts for highly efficient hydrogen evolution still remains a challenge.Herein, we demonstrated, for the first time, a one-step phosphidation strategy for simultaneously achieving phosphorus atom bonding with the benzene rings of ctfs and the anchoring of well-defined dicobalt phosphide (co2p) nanocrystals (∼7 nm).The hydrogen evolution activities of ctfs were significantly enhanced under simulated solar-light (7.6 mmol h-1g-1), more than 20 times higher than that of the ctf/co2p composite.Both comparative experiments andin situ x-ray photoelectron spectroscopy reveal that the strong interfacial p-c bonding and the anchoring of the co2p cocatalyst reverse the charge transfer direction from triazine to benzene rings, promote charge separation, and accelerate hydrogen evolution.Thus, the rational anchoring of transition-metal phosphides on conjugated polymers should be a promising approach for developing highly efficient photocatalysts for hydrogen evolution.

Journal: Chemical science (2022)
Publication types: Journal Article
Adolescents and Resilience: Factors Contributing to Health-Related Quality of Life during the COVID-19 Pandemic.

This study aimed to examine health-related quality of life of adolescents before and during the covid-19 outbreak, and its relationship to resilience embodied in hope and a sense of coherence.Typically developed adolescents between the ages of 13 to 18 participated in the study; 84 were recruited before the pandemic outbreak and 64 in march to april 2020 during the worldwide outbreak.The participants completed the pediatric quality of life inventory, sense of coherence scale, and children’s hope scale.During the outbreak, adolescents reported higher physical health-related quality of life scores (f(1146) = 3.710, p < 0.05, η2 = 0.027) and lower school health-related quality of life scores (f(1146) = 5.748, p < 0.05, η2 = 0.028), compared to adolescents during the pre-outbreak period.Furthermore, adolescents during the outbreak reported a significantly (p < 0.05) higher sense of coherence but no difference in levels of hope.Finally, the results of multiple linear regression indicated that resilience factors (hope and sense of coherence) contributed to the prediction of health-related quality of life, independent of socio-demographic variables.Hope and a sense of coherence were both found to positively impact one core aspect of health, which highlights the importance of addressing resilience factors in educational and therapeutic settings for adolescents thus that they are better able to adapt to stressful events such as pandemics.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article
Spinal location is prognostic of survival for solitary-fibrous tumor/hemangiopericytoma of the central nervous system.

Prior studies have highlighted infratentorial tumor location as a prognostic factor for solitary fibrous tumor (sft) and hemangiopericytoma (hpc) of the central nervous system (cns), and spinal location is considered a positive prognostic factor for other tumors of the cns.While sft/hpc of the cns is known to frequently arise from the spinal meninges, there are no case series that report outcomes for spinally located cns tumors, and their prognosis in relation to intracranial and other cns-located tumors is unknown.Objective to investigate outcomes for patients with sft/hpc of the spinal meninges.Methods the surveillance, epidemiology, and end-results program was used to identify patients with sft/hpc within the cns from 1993-2015.We retrospectively analyzed the relationship between tumor location (spinal vs.Brain and other cns) and survival.Results we identified 551 cases of cns sft/hpc, 64 (11.6%) of which were primary tumors of the spinal meninges.Spinal tumors were more likely than brain and other cns tumors to be sft vs.Hpc (37.5 vs.12%, p < 0.001), benign (42.2 vs.20.3%, p < 0.001), and less than 5 cm (53.1 vs.35.7%, p < 0.001).The 10-year survival rates for spinal and brain/other cns tumors were 85 and 58%, respectively.Median survival time was significantly longer for spinal tumors (median survival not reached vs.138 months, p = 0.03, hr = 0.41 [95% ci 0.18-0.94]).On multivariable analysis, spinal tumor location was associated with improved survival over tumors located in the brain and other cns (hr = 0.36 [95% ci 0.15-0.89], p = 0.03).Conclusion spinal tumor location is associated with improved survival in patients with sft/hpc of the cns.Larger institutional studies are necessary to characterize the relationship between tumor location and other relevant factors such as presentation and amenability to gross-total resection and adjuvant radiotherapy.Future studies exploring optimal management of spinally located tumors are also needed.

Journal: Journal of neuro-oncology (2019)
Publication types: Journal Article
Microtubule Severing Enzymes Oligomerization and Allostery: A Tale of Two Domains.

Severing proteins are nanomachines from the aaa+ (atpases associated with various cellular activities) superfamily whose function is to remodel the largest cellular filaments, microtubules.The standard aaa+ machines adopt hexameric ring structures for functional reasons, while being primarily monomeric in the absence of the nucleotide.Both major severing proteins, katanin and spastin, are believed to follow this trend.However, studies proposed that they populate lower-order oligomers in the presence of cofactors, which are functionally relevant.Our simulations show that the preferred oligomeric assembly is dependent on the binding partners and on the type of severing protein.Essential dynamics analysis predicts that the stability of an oligomer is dependent on the strength of the interface between the helical bundle domain (hbd) of a monomer and the convex face of the nucleotide binding domain (nbd) of a neighboring monomer.Hot spots analysis found that the region consisting of the hbd tip and the c-terminal (ct) helix is the only common element between the allosteric networks responding to nucleotide, substrate, and intermonomer binding.Clustering analysis indicates the existence of multiple pathways for the transition between the secondary structure of the hbd tip in monomers and the structure(s) it adopts in oligomers.

Journal: The journal of physical chemistry. B (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.
Acute combined collateral ligaments injury of the elbow without any fracture or dislocation-a case report.

Introduction the combination of both collateral ligaments injury in the elbow without fractures or dislocations is not reported in the literature.Case presentation a case report of rare acute combined collateral ligaments injury of the elbow was treated surgically by repairing both collateral ligament complexes with two different approaches.Clinical discussion clinical examination at 3 months showed a stable elbow with a flexion arc from 0 to 140.10 degrees residual varus laxity was observed.Pronation and supination were unrestricted.The patient experienced mild pain and was able to do push up and was completely satisfied with the result.Conclusion the case presented is the first case presented in the literature with acute combined and isolated collateral ligaments injury of the elbow.Based on the clinical result obtained.We propose acute surgical approach of both collateral ligaments for such types of injury.Level of evidence: 4

Journal: International journal of surgery case reports (2022)
Publication types: Case Reports;Journal Article