syedzayyan/paper_mill_benchmark huggingface dataset:
Psychological Capital on College Teachers' and Students' Entrepreneurial Performance and Sports Morality Under Social and Political Education.

The aim of this study was to improve the entrepreneurial performance (ep) and sports morality of college teacher-and-student entrepreneurs (i.e., college entrepreneurs).Consequently, psychological capital (psy cap) is creatively combined with social and political education (spe) to explore college entrepreneurs' ep and sports morality.First, following a theoretical model implementation, this article proposes several hypotheses.Then, a questionnaire survey (qs) was designed, and the data were analyzed.The results show that (1) gender has little impact on ep and sports morality; (2) psy cap significantly affects the ep of college entrepreneurs at the age of 33-38 years; (3) in terms of educational background, average scores of psy cap + spe of bachelors are the highest, followed by masters or above, and finally, the college undergraduate; (4) the average score of psy cap + spe of married respondents is 4.0, while that of the unmarried is 3.7; (5) there is a significant difference between college entrepreneurs' ep under the dimension of the basic enterprise situation; and (6) the average score of the length of entrepreneurship is 9.87, which has the most significant impact on the ep and sports morality, and the significance of sports morality is 0.04.Among them, the most significant impact on ep and sports morality is weekly sports participation, with a score of 9.67.Therefore, psy cap + spe plays a positive role in the ep of college entrepreneurs.In contrast, sports morality has little impact on ep.This study provides a reference for the research on the influence of entrepreneurship and sports morality of college entrepreneurs.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article
Systematic review with meta-analysis: the effects of family history on the risk of Barrett's oesophagus and oesophageal adenocarcinoma.

Current guidelines recommend different screening approaches for individuals with a family history of barrett's oesophagus (bo) or oesophageal adenocarcinoma (oac), varying from no screening to screening all individuals with a positive family history.Aims to determine evidence-based risk estimates for individuals with a family history of bo or oac methods: we systematically searched pubmed, embase and cochrane library until october 2020 to identify all studies that reported on the association between family history and the risk of bo and oac.Pooled summary estimates of adjusted relative risks and prevalence of familial bo/oac with 95% confidence intervals (cis) were calculated using a random effects model.Results fourteen studies comprising 16 189 bo/oac patients were analysed.Familial clustering was seen in 8.84% (95% ci: 5.54-13.82) and 4.37% (95% ci: 2.15-8.69) of patients with bo and oac, respectively (nine studies).Screening first-degree relatives of bo patients had a diagnostic yield between 12% and 44% for bo (four studies).However, the yield for high-grade dysplasia and oac was low (<2%).Individuals with a positive family history had a higher risk of having bo (a rr 3.26; 95% ci 1.43-7.40; i2= 46%; three studies) and oac (a rr 2.19; 95% ci 1.14-4.21; i2= 48%; five studies) compared to individuals without a family history.Conclusions a verified family history of bo or oac is a strong risk factor for both bo and oac.A positive family history could be a clinically meaningful way to identify high-risk individuals who may benefit from early detection strategies.

Journal: Alimentary pharmacology & therapeutics (2021)
Publication types: Journal Article;Meta-Analysis;Systematic Review
Stochastic frontier analysis as knowledge-based model to improve sparing of organs-at-risk for VMAT-treated prostate cancer.

Stochastic frontier analysis (sfa) is used as a novel knowledge-based technique in order to develop a predictive model of dosimetric features from significant geometric parameters describing a patient morphology.406 patients treated with vmat for prostate cancer were analyzed retrospectively.Cases were divided into three prescription-based groups.Seven geometric parameters are extracted to characterize the relationship between the organs-at-risk (bladder and rectum) with the planning volume (ptv).In total, 37 dosimetric parameters are tested for these two oars.Sfa allows the determination of the minimum achievable dose to the oar based on the geometric parameters.Stochastic frontiers are determined with a maximum likelihood estimation technique.The sfa model was tested using validation cohort (30 patients with prescribed dose between 60 and 70 gy) where 77% (23 out of 30) of the predicted dvhs present a 5% or less dose deterioration for the bladder and rectum with the planned dvh.Sfa can be used in ebrt planning as a predictive model based on anatomical features of previously treated plans.

Journal: Physics in medicine and biology (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Rubber-enhanced polyamide nanofibers for a significant improvement of CFRP interlaminar fracture toughness.

Nanofibrous mats provide substantial delamination hindering in composite laminates, especially if the polymer (as rubbers) can directly toughen the composite resin.Here, the well-known nylon 66 nanofibers were impregnated with nitrile butadiene rubber (nbr) for producing rubber/thermoplastic membranes for hampering the delamination of epoxy carbon fiber reinforced polymers (cfrps).The starting polyamide mats were electrospun using two different solvent systems, and their effect on the mat's thermal and mechanical properties was investigated, as well as the laminate mode i delamination resistance via double cantilever beam (dcb) tests.Plain nylon 66 mats electrospun from formic acid/chloroform perform better than the ones obtained from a solvent system containing trifluoroacetic acid, showing up to + 64% vs + 53% in interlaminar fracture toughness (gi), respectively.The effect of nbr coating benefits both nanofiber types, significantly raising the gi.The best results are obtained when interleaving medium-thickness and lightweight mats (20 μm, 9-10 g/m2) with 70-80 wt% of loaded rubber, achieving up to + 180% in gi.The work demonstrates the ability of nbr at improving the delamination hindering of common polyamide nonwovens, paving the way to the use of nbr-coated nylon 66 nanofibers as effective interleaves for gienhancement and overall composite safety improvement.

Journal: Scientific reports (2022)
Publication types: Journal Article
Failure of Abdominal Wall Closure: Prevention and Management.

This article reviews evidence-based techniques for abdominal closure and management strategies when abdominal wall closures fail.In particular, optimal primary fascial closure techniques, the role of prophylactic mesh, considerations for combined hernia repair, closure techniques when the fascia cannot be closed primarily, and management approaches for fascial dehiscence are reviewed.

Journal: The Surgical clinics of North America (2021)
Publication types: Journal Article;Review
Layer Rotation-Angle-Dependent Excitonic Absorption in van der Waals Heterostructures Revealed by Electron Energy Loss Spectroscopy.

Heterostructures comprising van der waals (vd w) stacked transition metal dichalcogenide (tmdc) monolayers are a fascinating class of two-dimensional (2d) materials.The presence of interlayer excitons, where the electron and the hole remain spatially separated in the two layers due to ultrafast charge transfer, is an intriguing feature of these heterostructures.The optoelectronic functionality of 2d heterostructure devices is critically dependent on the relative rotation angle of the layers.However, the role of the relative rotation angle of the constituent layers on intralayer absorption is not clear yet.Here, we investigate mo s2/wse2vd w heterostructures using monochromated low-loss electron energy loss (eel) spectroscopy combined with aberration-corrected scanning transmission electron microscopy and report that momentum conservation is a critical factor in the intralayer absorption of tmdc vd w heterostructures.The evolution of the intralayer excitonic low-loss eel spectroscopy peak broadenings as a function of the rotation angle reveals that the interlayer charge transfer rate can be about an order of magnitude faster in the aligned (or anti-aligned) case than in the misaligned cases.These results provide a deeper insight into the role of momentum conservation, one of the fundamental principles governing charge transfer dynamics in 2d vd w heterostructures.

Journal: ACS nano (2019)
Publication types: Journal Article
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.

Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci.However, the nature and mechanisms of these pleiotropic effects remain unclear.We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and tourette syndrome.Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders.Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders.The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes.These findings have important implications for psychiatric nosology, drug development, and risk prediction.

Journal: Cell (2019)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Advanced Squamous Cell Carcinomas of the Pelvic and Perineal Region: A Comprehensive Genomic Profiling Study.

Advanced pelvic squamous cell carcinoma (p scc) is a broad category of cancers affecting different pelvic organs and usually featuring unfavorable clinical outcomes.Thus, we aimed to assess genomic differences among p scc cases and learn whether p scc could potentially benefit from targeted therapies and/or immunotherapy.Materials and methods a total of 1917 advanced p sccs, including penile (pen scc), male urethral (murth scc), male anal (man scc), female urethral (furth scc), vulvar (vul scc), cervical (crv scc), female anal (fan scc), and vaginal (vag scc), underwent comprehensive genomic profiling (cgp).We used hybrid capture-based cgp to evaluate recurrent genomic alterations (gas).Tumor mutational burden (tmb) was determined on up to 1.1 mb of sequenced dna and microsatellite instability (msi) was determined on up to 95 loci.Programmed cell-death-ligand-1 (pd-l1) expression was determined by immunohistochemistry (ihc; dako 22c3).Results pik3ca was the most frequently identified potentially "actionable" ga (22%-43%), followed by m tor pathway [pten (0%-18%), fbxw7 (7%-29%)], and cell-cycle gas.Dna-damage response (ddr) gas and receptor-tyrosine kinase (rtk) targeted options were uncommon.Notch1 gas were present in >15% of pen scc and vulv scc.Tmb ≥10 mut/mb was >15% in man scc, fan scc, crv scc, and vag scc.Pd-l1 high expression was >18% in all p scc except urth scc, man scc, and vag scc.Hpv-16/18 detection was highest in man scc, fan scc, and crv scc.Conclusion despite similar histology, p sccs can differ in gas and hpv status.Overall, pik3ca is the most frequent potentially "targetable" ga followed by m tor and cell cycle pathway.Rtk and ddr gas are rare in p scc.Immunotherapy could be considered for p scc management based on tmb and pd-l1 expression.

Journal: The oncologist (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Metamaterial Absorbers: From Tunable Surface to Structural Transformation.

Since the first demonstration, remarkable progress has been made in the theoretical analysis, structural design, numerical simulation, and potential applications of metamaterial absorbers (mas).With the continuous advancement of novel materials and creative designs, the absorption of mas is significantly improved over a wide frequency spectrum from microwaves to the optical regime.Further, the integration of active elements into the ma design allows the dynamical manipulation of electromagnetic waves, opening a new platform to push breakthroughs in metadevices.In the last several years, numerous efforts have been devoted to exploring innovative approaches for incorporating tunability to mas, which is highly desirable because of the progressively increasing demand on designing versatile metadevices.Here, a comprehensive and systematical overview of active mas with adaptive and on-demand manner is presented, highlighting innovative materials and unique strategies to precisely control the electromagnetic response.In addition to the mainstream method by manipulating periodic patterns, two additional approaches, including tailoring dielectric spacer and transforming overall structure are called back.Following this, key parameters, such as operating frequency, relative tuning range, and switching speed are summarized and compared to guide for optimum design.Finally, potential opportunities in the development of active mas are discussed.

Journal: Advanced materials (Deerfield Beach, Fla.) (2022)
Publication types: Journal Article;Review
Deficiency of p53 Causes the Inadequate Expression of miR-1246 in B Cells of Systemic Lupus Erythematosus.

Underexpression of p53 is considered the leading cause of the decreased mi r-1246 expression in b cells of systemic lupus erythematosus (sle) patients, yet the exact mechanism of action still remains unclear.To further explore the molecular mechanism of p53 upregulating mi r-1246 expression, we targeted the methylation and acetylation of histone h3 in the mi r-1246 promoter region of sle b cells.We found that increased histone h3 trimethylation at lys27(h3k27me3) and decreased histone h3 acetylation at lys9and lys14(h3k9/k14ac) in the mi r-1246 promoter region are essential for the low expression of mi r-1246 in sle b cells.P53 can promote mi r-1246 transcription by recruiting jumonji domain-containing protein 3 (jmjd3), e1a-binding protein p300 (ep300), and creb-binding protein (cbp) to bind to the mi r-1246 promoter, downregulating h3k27me3 and upregulating h3k9/k14ac.Furthermore, early b cell factor 1 (ebf1), cd40, cd38, and x box binding protein-1 (xbp-1) expression levels in sle b cells transfected with p53 expression plasmid were significantly decreased, whereas autoantibody ig g production in autologous cd4+t cells cocultured with overexpressed p53 sle b cells was reduced.Collectively, our data suggest that the reduction of p53 decreases mi r-1246 expression via upregulation of h3k27me3 and downregulation of h3k9/14ac, which in turn results in sle b cell hyperactivity.

Journal: Journal of immunology (Baltimore, Md. : 1950) (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Comparison of long occlusive femoropopliteal de novo versus previous endovascularly treated lesions managed with in situ saphenous bypass.

The aim of this study was to compare the 2-year outcomes of de novo versus postendovascular lesion treatment of femoropopliteal occlusions included in a national, multicenter, observational, prospective registry based on the treatment of critical limb-threatening ischae mia with infragenicular bypass adopting in situ saphenous vein technique (limbsave) registry.Methods from january 2018 to december 2019, 541 patients from 43 centers have been enrolled in the limbsave registry.Of these patients, 460 were included in the present study: 341 (74.1%) with de novo lesions (dn group) and 119 (25.9%) with postendovascular treatment lesions (pe group).Initial outcome measures were assessed at 30 days after treatment.Furthermore, at the 2-year follow-up, the estimated outcomes of primary patency, primary-assisted patency, secondary patency, and limb salvage were analyzed with kaplan-meier curves and compared between groups with the log-rank test.Results both groups were homogeneous in terms of demographic data, preoperative risk factors, and clinical presentation.However, compared with dn group, more patients in pe group had a great saphenous vein diameter of less than 3 mm (11.1% vs 21%; p = .007).Intraoperatively, both groups showed similar distal anastomosis sites: below-the-knee popliteal artery (63% dn group, 66.4% pe group) and tibial vessel (37% dn group, 33.6% pe group) (p = .3).The overall mean duration of follow-up was 11.6 months (range, 1-24 months).At the 2-year follow-up, there were no differences between the two groups in terms of primary patency (66.3% dn group vs 74.1% pe group; p = .9), primary-assisted patency (78.2% dn group vs 79.5% pe group; p = .2), secondary patency (85.1% dn group vs 91.4% pe group; p = .2), and limb salvage (95.2% dn group vs 95.1% pe group; p = .9).Conclusions the limbsave registry did not show a worsening of overall patency and limb salvages rates at the 2-year follow-up in patients undergoing in situ saphenous bypass after a failed endovascular approach for long femoropopliteal occlusive disease.This finding is in contrast with what has been published in literature.

Journal: Journal of vascular surgery (2022)
Publication types: Journal Article;Multicenter Study;Observational Study
Early Toll-like receptor 4 inhibition improves immune dysfunction in the hippocampus after hypoxic-ischemic brain damage.

Toll-like receptor 4 (tlr4) is implicated in neonatal hypoxic-ischemic brain damage (hibd), but the underlying mechanism is unclear.hypothesis: we hypothesized that tlr4 mediates brain damage after hypoxic ischemia (hi) by inducing abnormal neuroimmune responses, including activation of immune cells and expression disorder of immune factors, while early inhibition of tlr4 can alleviate the neuroimmune dysfunction.method: postnatal day 7 rats were randomized into control, hi, and hi+tak-242 (tak-242) groups.The hibd model was developed using the rice-vannucci method (the left side was the ipsilateral side of hi).Tak-242 (0.5 mg/kg) was given to rat pups in the tak-242 group at 30 min before modeling.Immunofluorescence, immunohistochemistry, and western blotting were used to determine the tlr4 expression; the number of iba-1+, gfap+, cd161+, mpo+, and cd3+ cells; icam-1 and c3a expression; and interleukin (il)-1β, tumor necrosis factor (tnf)-α, and il-10 expression in the hippocampal ca1 region.result:significantly increased tlr4 expression was observed in the left hippocampus, and was alleviated by tak-242.The significant increases in iba-1+, mpo+, and cd161+ cells at 24 h and 7 days after hi and in gfap+ and cd3+ t cells at 7 days after hi were also counteracted by tak-242, but no significant differences were observed among groups at 24 h after hi.Icam-1 expression increased 24 h after hi, while c3a expression decreased; tak-242 also alleviated these changes.Tnf-α and il-1β expression increased, while il-10 expression decreased at 24 h and 7 days after hi; tak-242 counteracted the increased tnf-α and il-1β expression at 24 h and the changes in il-1β and il-10 at 7 days, but induced no significant differences in il-10 expression at 24 h and tnf-α expression at 7 days.conclusion:early tlr4 inhibition can alleviate hippocampal immune dysfunction after neonatal hibd.

Journal: International journal of medical sciences (2022)
Publication types: Journal Article
PSG7 indicates that age at diagnosis is associated with papillary thyroid carcinoma: A study based on the cancer genome atlas data.

The age of the patients at diagnosis (age at diagnosis) is a self-contained element of danger for the prognosis of patients with papillary thyroid carcinoma (ptc), which has been well recognized and continuously adopted by the international cancer staging system.However, few studies have investigated its intrinsic mechanisms.In this study, we aim to comprehensively reveal the age-related pathogenesis of ptc and identify potential prognostic biomarkers.We divided the samples into two groups, young and elderly, to filter differentially expressed genes in the cancer genome atlas (tcga), with an age of 55 years serving as a cutoff.Moreover, we combined univariate, lasso, and multivariate cox regression analyses to construct age-related signatures for predicting progression-free survival.Additionally, functional enrichment analysis, immune infiltration analysis, differential expression analysis, clinicopathological correlation analysis, and drug sensitivity analysis were performed in different risk subgroups and expression subgroups.We screened 88 upregulated genes and 58 downregulated genes.Both the lasso regression model that is validated in tcga and the model of six age-related prognostic genes (igf2bp1, gprc6a, il37, crct1, semg1, and psg7) can be used to evaluate the progression-free survival of ptc patients.The go, kegg, and gsea analyses revealed that each key gene was closely associated with ptc development.Furthermore, cd8+t cells decreased significantly, while regulatory t cells increased dramatically in the high-risk and psg7 high expression groups.Psg7 was remarkably correlated with clinicopathological parameters (pathologic stage, t stage, and n stage) of ptc patients, and psg7 expression was elevated in tumor samples from both tcga and the gene expression omnibus and was strongly associated with progressive stage and poor prognosis.Our results provide an innovative understanding of the age-related molecular mechanisms of ptc development.Psg7 was identified to exert a critical role in ptc progression and may serve as a promising strategy for predicting the prognosis of ptc.

Journal: Frontiers in genetics (2022)
Publication types: Journal Article