syedzayyan/paper_mill_benchmark huggingface dataset:
Association of Blood Pressure Lowering With Incident Dementia or Cognitive Impairment: A Systematic Review and Meta-analysis.

Importance the benefit of blood pressure lowering for the prevention of dementia or cognitive impairment is unclear.Objective to determine the association of blood pressure lowering with dementia or cognitive impairment.Data sources and study selection search of pub med, embase, and central for randomized clinical trials published from database inception through december 31, 2019, that evaluated the association of blood pressure lowering on cognitive outcomes.The control groups consisted of either placebo, alternative antihypertensive agents, or higher blood pressure targets.Data extraction and synthesis data were screened and extracted independently by 2 authors.Random-effects meta-analysis models were used to report pooled treatment effects and cis.Main outcomes and measures the primary outcome was dementia or cognitive impairment.The secondary outcomes were cognitive decline and changes in cognitive test scores.Results fourteen randomized clinical trials were eligible for inclusion (96 158 participants), of which 12 reported the incidence of dementia (or composite of dementia and cognitive impairment [3 trials]) on follow-up and were included in the primary meta-analysis, 8 reported cognitive decline, and 8 reported changes in cognitive test scores.The mean (sd) age of trial participants was 69 (5.4) years and 40 617 (42.2%) were women.The mean systolic baseline blood pressure was 154 (14.9) mm hg and the mean diastolic blood pressure was 83.3 (9.9) mm hg.The mean duration of follow-up was 49.2 months.Blood pressure lowering with antihypertensive agents compared with control was significantly associated with a reduced risk of dementia or cognitive impairment (12 trials; 92 135 participants) (7.0% vs 7.5% of patients over a mean trial follow-up of 4.1 years; odds ratio [or], 0.93 [95% ci, 0.88-0.98]; absolute risk reduction, 0.39% [95% ci, 0.09%-0.68%]; i2 = 0.0%) and cognitive decline (8 trials) (20.2% vs 21.1% of participants over a mean trial follow-up of 4.1 years; or, 0.93 [95% ci, 0.88-0.99]; absolute risk reduction, 0.71% [95% ci, 0.19%-1.2%]; i2 = 36.1%).Blood pressure lowering was not significantly associated with a change in cognitive test scores.Conclusions and relevance in this meta-analysis of randomized clinical trials, blood pressure lowering with antihypertensive agents compared with control was significantly associated with a lower risk of incident dementia or cognitive impairment.

Journal: JAMA (2020)
Publication types: Journal Article;Meta-Analysis;Research Support, Non-U.S. Gov't;Systematic Review
Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma.

Uterine serous carcinoma (usc) is a highly aggressive endometrial cancer subtype with limited therapeutic options and a lack of targeted therapies.While mutations to ppp2r1a, which encodes the predominant protein phosphatase 2a (pp2a) scaffolding protein aα, occur in 30% to 40% of usc cases, the clinical actionability of these mutations has not been studied.Using a high-throughput screening approach, we showed that mutations in aα results in synthetic lethality following treatment with inhibitors of ribonucleotide reductase (rnr).In vivo, multiple models of aα mutant uterine serous tumors were sensitive to clofarabine, an rnr inhibitor (rnri).Aα-mutant cells displayed impaired checkpoint signaling upon rnri treatment and subsequently accumulated more dna damage than wild-type (wt) cells.Consistently, inhibition of pp2a activity using lb-100, a catalytic inhibitor, sensitized wt usc cells to rnri.Analysis of the cancer genome atlas data indicated that inactivation of pp2a, through loss of pp2a subunit expression, was prevalent in usc, with 88% of patients with usc harboring loss of at least one pp2a gene.In contrast, loss of pp2a subunit expression was rare in uterine endometrioid carcinomas.While rnri are not routinely used for uterine cancers, a retrospective analysis of patients treated with gemcitabine as a second- or later-line therapy revealed a trend for improved outcomes in patients with usc treated with rnri gemcitabine compared with patients with endometrioid histology.Overall, our data provide experimental evidence to support the use of ribonucleotide reductase inhibitors for the treatment of usc.Significance a drug repurposing screen identifies synthetic lethal interactions in pp2a-deficient uterine serous carcinoma, providing potential therapeutic avenues for treating this deadly endometrial cancer.

Journal: Cancer research (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Real-Time Gait Phase and Task Estimation for Controlling a Powered Ankle Exoskeleton on Extremely Uneven Terrain.

Positive biomechanical outcomes have been reported with lower-limb exoskeletons in laboratory settings, but these devices have difficulty delivering appropriate assistance in synchrony with human gait as the task or rate of phase progression change in real-world environments.This paper presents a controller for an ankle exoskeleton that uses a data-driven kinematic model to continuously estimate the phase, phase rate, stride length, and ground incline states during locomotion, which enables the real-time adaptation of torque assistance to match human torques observed in a multi-activity database of 10 able-bodied subjects.We demonstrate in live experiments with a new cohort of 10 able-bodied participants that the controller yields phase estimates comparable to the state of the art, while also estimating task variables with similar accuracy to recent machine learning approaches.The implemented controller successfully adapts its assistance in response to changing phase and task variables, both during controlled treadmill trials (n=10, phase rmse: 4.8 ± 2.4%) and a real-world stress test with extremely uneven terrain (n=1, phase rmse: 4.8 ± 2.7%).

Journal: IEEE transactions on robotics : a publication of the IEEE Robotics and Automation Society (2023)
Publication types: Journal Article
The Role of Mindfulness in Mitigating the Detrimental Effects of Harsh Parenting among Chinese Adolescents: Testing a Moderated Mediation Model in a Three-Wave Study.

Based on the conservation of resources theory, this study aimed to investigate the mediating role of depressive symptoms and the moderating role of mindfulness in the association between harsh parenting and adolescent suicidal ideation in the chinese cultural context.Using a three-wave (i.e., three months apart) data collection among 371 chinese adolescents, this study found that depressive symptoms mediated the relationship between harsh parenting and adolescent suicidal ideation.Moreover, adolescent mindfulness mitigated the effects of harsh parenting on suicidal ideation, as well as the indirect effect of harsh parenting on suicidal ideation via depressive symptoms.The theoretical and practical implications are discussed.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article
A bifunctional peptide-based fluorescent probe for ratiometric and "turn-on" detection of Zn(II) ions and its application in living cells.

In this work, a bifunctional peptide-based fluorescent probe l containing a tetrapeptide scaffold (pro-gly-his-trp-nh2) and a dansyl group was synthesized using solid phase peptide synthesis (spps) technology.As designed, l, based on a fret mechanism, exhibited high selectivity, excellent ratiometric signals, and fast response to zn2+in aqueous solutions at an excitation wavelength of 280 nm.In addition, when excited at 320 nm, l exhibited a fluorescent "turn-on" response towards zn2+based on pet mechanism.More importantly, the stoichiometry of l and zn2+was determined to be 2:1 by fluorescent titration, job's plot method, and esi-ms spectrometry.The association constant for zn2+ions was determined to be 6.26 × 108m-2, while the limit of detection (lod) of l was estimated as 5.43 n m, which is a much lower value than who and epa guidelines for drinking water.Moreover, l was successfully applied to detect both zn2+and cu2+in living cells due to good biocompatibility and excellent low toxicity.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2022)
Publication types: Journal Article
Diversity and composition of microbiota during fermentation of traditional Nuodeng ham.

The microbial community is one of the most important factors in shaping the characteristics of fermented food.Nuodeng ham, traditionally produced and subjected to 1-4 years of fermentation, is a dry fermented food product with cultural and economic significance to locals in southwestern china.In this study, we aimed to characterize the microbiota and physicochemical profiles of nuodeng ham across different stages of fermentation.Ham samples from each of the four years were analyzed by sequencing bacterial 16s r rna gene and fungal internal transcribed spacer sequence, in order to characterize the diversity and composition of their microflora.A total of 2,679,483 bacterial and 2,983,234 fungal sequences of high quality were obtained and assigned to 514 and 57 genera, respectively.Among these microbes, staphylococcus and candida were the most abundant genera observed in the ham samples, though samples from different years showed differences in their microbial abundance.Results of physicochemical properties (p h, water, amino acid, na cl, nitrate and nitrite contents, and the composition of volatile compounds) revealed differences among the ham samples in the composition of volatile compounds, especially in the third year samples, in which no nitrite was detected.These results suggest that the structure and diversity of microbial communities significantly differed across different stages of fermentation.Moreover, the third year hams exhibits a unique and balanced microbial community, which might contribute to the special flavor in the green and safe food products.Thus, our study lends insights into the production of high quality nuodeng ham.

Journal: Journal of microbiology (Seoul, Korea) (2021)
Publication types: Journal Article
Population pharmacokinetic/pharmacodynamic modeling of the psychedelic experience induced by N,N-dimethyltryptamine - Implications for dose considerations.

N,n-dimethyltryptamine (dmt) is a psychedelic compound that is believed to have potential as a therapeutic option in several psychiatric disorders.The number of clinical investigations with dmt is increasing.However, very little is known about the pharmacokinetic properties of dmt as well as any relationship between its exposure and effects.This study aimed to characterize population pharmacokinetics of dmt as well as the relationship between dmt plasma concentrations and its psychedelic effects as measured through subjective intensity ratings.Data were obtained from 13 healthy subjects after intravenous administration of dmt.The data were analyzed using nonlinear mixed-effects modeling in nonmem.Dmt plasma concentrations were described by a two-compartment model with first-order elimination leading to formation of the major metabolite indole 3-acetic acid.The relationship between plasma concentrations and psychedelic intensity was described by an effect site compartment model with a sigmoid maximum effect (emax) response.Dmt clearance was estimated at 26 l/min, a high value indicating elimination of dmt to be independent of blood flow.Higher concentrations of dmt were associated with a more intense experience with the concentration of dmt at the effect site required to produce half of the maximum response estimated at 95 n m.The maximum achievable intensity rating was 10 and the simulated median maximum rating was zero, 2, 4, 8, and 9 after doses of 1, 4, 7, 14, and 20 mg, respectively.The model can be useful in predicting suitable doses for clinical investigations of dmt based on the desired intensity of the subjective experience.

Journal: Clinical and translational science (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Debonding of cast metal-based cantilever and fixed-fixed resin-retained bridgework: A review of the literature.

Cast metal-based resin-retained bridgework (rrb) offers a practical, conservative approach when restoring edentulous spaces.This review examines the debonding of cast metal-based rrb, comparing cantilever resin-retained bridgework (crrb) and fixed-fixed resin-retained bridgework (frrb) designs taking into context developments in rrb design, construction, and cementation over time.Methods an electronic search was conducted through medline and embase with the aid of boolean operators to combine the following key words: "adhesive bridges", "resin-bonded bridges", "resin-retained bridges", "resin-bonded fixed partial dentures", "cantilever", "debond", "fixed-fixed", "decementation", "failure", "success", "outcome", "longevity" and "survival".The search was limited to peer-reviewed articles written in english and published from 1995 through to 2019.Main findings thirty-one studies were included.Five studies compared the longevity of crrb versus frrb, five assessed the clinical performance of crrbs alone, and 21 studies assessed the clinical performance of frrbs.There was great variability in study design and the reporting of clinical outcomes, and an analysis and critique of the included papers is provided.Overall, crrb tend to debond less and hence provide longer-term and more reliable clinical service when compared to frrb.Principal conclusions more high-level, long-term, prospective and clinical controlled trials are required to further analyse and evaluate the long-term outcomes of cast metal-based rrb.

Journal: Primary dental journal (2022)
Publication types: Journal Article;Review
MaxQuant.Live Enables Global Targeting of More Than 25,000 Peptides.

Mass spectrometry (ms)-based proteomics is often performed in a shotgun format, in which as many peptide precursors as possible are selected from full or ms1 scans so that their fragment spectra can be recorded in ms2 scans.Although achieving great proteome depths, shotgun proteomics cannot guarantee that each precursor will be fragmented in each run.In contrast, targeted proteomics aims to reproducibly and sensitively record a restricted number of precursor/fragment combinations in each run, based on prescheduled mass-to-charge and retention time windows.Here we set out to unify these two concepts by a global targeting approach in which an arbitrary number of precursors of interest are detected in real-time, followed by standard fragmentation or advanced peptide-specific analyses.We made use of a fast application programming interface to a quadrupole orbitrap instrument and real-time recalibration in mass, retention time and intensity dimensions to predict precursor identity.Max quant.live is freely available (www.maxquant.live) and has a graphical user interface to specify many predefined data acquisition strategies.Acquisition speed is as fast as with the vendor software and the power of our approach is demonstrated with the acquisition of breakdown curves for hundreds of precursors of interest.We also uncover precursors that are not even visible in ms1 scans, using elution time prediction based on the auto-adjusted retention time alone.Finally, we successfully recognized and targeted more than 25,000 peptides in single lc-ms runs.Global targeting combines the advantages of two classical approaches in ms-based proteomics, whereas greatly expanding the analytical toolbox.

Journal: Molecular & cellular proteomics : MCP (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Calibration of blood pressure measurements in the Jackson Heart Study.

In longitudinal research studies with follow-up examinations, the devices used to measure phenotypes may change over time.When a device change occurs, the two devices should be calibrated to each other to ensure that measurements are comparable.This paper details the jackson heart study (jhs) blood pressure (bp) comparability study.Participants and methods during its second clinic exam (2005-2008), the jhs switched from a random-zero sphygmomanometer (rzs) bp measurement device to an oscillometric device (od).During this exam, bp measurements from both an rzs and an od were taken simultaneously in 2117 participants for the purpose of calibration.Five methods for calibrating systolic bp (sbp) and diastolic bp (dbp) were considered: ignoring the change, ordinary least squares regression, adding the average difference, deming regression, and robust regression.Results using the rzs and od, the mean (sd) sbp was 125.5 (19.2) and 126.5 (19.9), respectively, and the mean (sd) dbp was 76.4 (10.6) and 74.0 (11.0), respectively.The correlation between rzs and the od was 0.90 for sbp and 0.80 for dbp.The prevalence of high bp and hypertension and associations with albuminuria were similar when applying each of the five calibration methods.Robust regression was chosen for calibration, giving the following equations:(equation is included in full-text article.)these equations had a higher r statistic than using calibration equations from the coronary artery risk development in young adults study and the heinz nixdorf recall study.Conclusions the jhs bp data have been calibrated using the above equations for use in future analyses.

Journal: Blood pressure monitoring (2019)
Publication types: Comparative Study;Journal Article
Unenhanced multidetector computed tomography findings in acute central pulmonary embolism.

Computed tomography pulmonary angiography (ctpa) is the gold standard for the diagnosis of pulmonary embolism (pe).However, contrast is contraindicated in some patients.The purpose of this study was to determine the diagnostic accuracy of unenhanced multidetector ct (mdct) for diagnosis of central pe using ctpa as the gold standard.Methods the records of patients with suspected pe seen between 2010 and 2013 were retrospectively reviewed.Inclusion criteria were an acute, central pe confirmed by ctpa and non-enhanced mdct before contrast injection.Patients with a pe ruled out by ctpa served as a control group.Mdct findings studied were high-attenuation emboli in pulmonary artery (pa), main pa dilatation > 33.2 mm, and peripheral wedge-shaped consolidation.Receiver operating characteristic (roc) analysis was used to determine the sensitivity and specificity of unenhanced mdct to detect pe.Wells score of all patients were calculated using data extracted from medical records prior to imaging analysis.Results thirty-two patients with a pe confirmed by ctpa and 32 with a pe ruled out by ctpa were included.Among the three main mdct findings, high-attenuation emboli in the pa showed best diagnostic performance (sensitivity 72.9%; specificity 100%), followed by main pa dilatation > 33.2 mm (sensitivity 46.9%; specificity 90.6%), and peripheral wedge-shaped consolidation (sensitivity 43.8%; specificity 78.1%).Given any one or more positive findings on unenhanced mdct, the sensitivity was 96.9% and specificity was 71.9% for a diagnosis of pe in patients.The area under the curve (auc) of a composite measure of unenhanced mdct findings (0.909) was significantly higher than that of the wells score (0.688), indicating unenhanced mdct was reliable for detecting pe than wells score.Conclusions unenhanced mdct is an alternative for the diagnosis of acute central pe when ctpa is not available.

Journal: BMC medical imaging (2019)
Publication types: Journal Article
Chemical Composition and Phytotoxic, Antibacterial and Antibiofilm Activity of the Essential Oils of Eucalyptus occidentalis, E. striaticalyx and E. stricklandii

The eucalyptusgenus (myrtaceae) is characterized by a richness in essential oils (eo) with multiple biological activities.This study reports the chemical composition and the phytotoxic and antimicrobial activities of the eos from tunisian e.occidentalis,e.striaticalyxand e.stricklandii.The eos were analyzed using gc/ms and their phytotoxicities were assessed against the germination and seedling growth of sinapis arvensis,trifolium campestreand lolium rigidum.Antimicrobial activity was investigated against both gram-negative (pseudomonas aeruginosa, escherichia coliand acinetobacter baumannii)and gram-positive (staphylococcus aureusand listeria monocytogenes) bacteria.The inhibition of biofilm formation and its metabolism was determined at different times.All eos were rich in oxygenated monoterpenes (36.3-84.8%); the eo of e.occidentaliswas rich in sesquiterpenes, both oxygenated and hydrocarbon (40.0% and 15.0%, respectively).Eucalyptol was the main constituent in all samples.The eos showed phytotoxic activity on seed germination and seedling growth, depending both on chemical composition and weed.The eos show a remarkable antibacterial potential resulting in a significant inhibition of the formation of bacterial biofilm and its metabolism, depending on the eo and the strain, with activity on the mature biofilm as well.Therefore, these eucalyptus eos could have potential applications both in the food and health fields.

Journal: Molecules (Basel, Switzerland) (2022)
Publication types: Journal Article
Analysis and Prevention and Control System of Domino Accident Risk Data in Chemical Parks Based on Topological Neural Network.

A topologically based neural network algorithm is used to conduct an in-depth study and analysis of domino accident risk data in chemical parks, and this is used to construct a prevention and control system applied to the safety prediction of chemical parks.Firstly, the operating model of the flue gas turbine is expanded and analyzed according to the basic theory of topology, and the object element model is constructed to determine the feature vector and potential risk level.Then, the idea of differential evolution is introduced into the topological neural network to solve the problem that the learning rate and weighting coefficients are difficult to determine, and then the complete de-enn algorithm is proposed and tested with the uci standard data set to verify the effectiveness of the algorithm.Finally, the algorithm is applied to the potential risk identification of the smoke machine operation model, and the experimental results show that the method not only has a simple structure, short running time, and high prediction accuracy but also has excellent generalization ability.For the inherent risk and domino effect risk of chemical equipment in chemical fiber enterprises, the accident risk assessment method based on the protection layer analysis method is proposed; combined with the probability of domino accident and personnel vulnerability model based on the comprehensive analysis of the research results of the allowable risk standard, the allowable risk standard applicable to chemical fiber production enterprises in china is proposed.Given the potential accident risk characteristics of chemical fiber production enterprises, the calculation method of firefighting demand and firefighting capacity of firefighting system is given; the index system of firefighting system emergency response capacity assessment is constructed from three aspects of firefighting system integrity, reliability, and effectiveness, and the assessment model and grade classification standard of firefighting emergency response capacity of chemical fiber production enterprises are determined.

Journal: Computational intelligence and neuroscience (2022)
Publication types: Journal Article