syedzayyan/paper_mill_benchmark huggingface dataset:
Palliative-care nurses' and physicians' descriptions of the competencies needed in their working units.

Specialists were asked to describe the most essential palliative and end-of-life care competencies needed in their working units, in order to deepen the understanding of the phenomenon.Aim to describe the most essential competencies of palliative-care nurses and physicians.Methods the data was collected using an open-ended question in a survey sent to registered nurses (n=129) working within palliative care and to physicians (n=64) with a special competency in palliative care.The data was analysed using content analysis.Results the description of the most essential competencies included 16 main categories and 63 subcategories in total.The three strongest main categories were 'clinical competence', 'competence in social interactions' and 'competence in giving support'.Eleven main categories were based on both nurses' and physicians' data, while five main categories were created from nurses' data only.Conclusion interprofessional palliative-care education is recommended for the undergraduate and postgraduate education of nurses and physicians.

Journal: International journal of palliative nursing (2022)
Publication types: Journal Article
Multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis.

Functional brain networks and the perception of pain can fluctuate over time.However, how the time-dependent reconfiguration of functional brain networks contributes to chronic pain remains largely unexplained.Here, we explored time-varying changes in brain network integration and segregation during pain over a disease-affected area (joint) compared to a neutral site (thumbnail) in 28 patients with rheumatoid arthritis (ra) in comparison with 22 healthy controls (hc).During functional magnetic resonance imaging, all subjects received individually calibrated pain pressures corresponding to visual analog scale 50 mm at joint and thumbnail.We implemented a novel approach to track changes of task-based network connectivity over time.Within this framework, we quantified measures of integration (participation coefficient, pc) and segregation (within-module degreez-score).Using these network measures at multiple spatial scales, both at the level of single nodes (brain regions) and communities (clusters of nodes), we found that pc at the community level was generally higher in ra patients compared to hc during and after painful pressure over the inflamed joint and corresponding site in hc.This shows that all brain communities integrate more in ra patients than in hc for time points following painful stimulation to a disease-relevant body site.However, the elevated community-related integration seen in patients appeared to not pertain uniquely to painful stimulation at the inflamed joint, but also at the neutral thumbnail, as integration and segregation at the community level did not differ across body sites in patients.Moreover, there was no specific nodal contribution to brain network integration or segregation.Altogether, our findings indicate widespread and persistent changes in network interaction in ra patients compared to hc in response to painful stimulation.

Journal: Frontiers in neuroscience (2022)
Publication types: Journal Article
Assessment of sequential extraction methods for the prediction of bioavailability of elements in plants grown on agricultural soils near to boron mines in Turkey.

Two sequential extraction methods (bcr sequential extraction method and a newly proposed sequential extraction method) were used to evaluate the bioavailability of the elements from the contaminated soils to different plants.The concentrations of as, b, cd, co, cr, cu, fe, mn, ni, pb and zn in acid digests from different plants collected from the fields near to boron mines in turkey were determined using icp-ms.The levels of the elements in some plants exceeded the limits of maximum and guideline levels for as, cd and pb; tolerable upper intake levels (uls) for ni and b; adequate intakes (ais) for cr and mn and recommended dietary allowances (rdas) for cu, fe and zn.The average transfer factor values for elements were in the order of b>ni>zn>cu>cr>co>fe>mn>cd>pb>as.In most cases, principal component analysis and correlation analysis showed that these methods gave similar results.However, the newly proposed sequential extraction method is a more detailed method, capable of separating metals associated with manganese oxides and iron as amorphous and crystalline fractions.Three different fractions are produced for these environmental phases instead of the bcr sequential extraction procedure in which they are represented together in the second fraction.The new method therefore specifically fractionates bioavailable manganese and iron to plants.

Journal: Talanta (2019)
Publication types: Journal Article
Real-world experience with Ropeginterferon-alpha 2b (Besremi) in Philadelphia-negative myeloproliferative neoplasms.

/purpose ropeginterferon alpha-2b (ropeg) is a novel pegylated interferon-alpha recently approved for the treatment of polycythemia vera (pv) in europe.However, other than data from clinical trials, little is known about this agent in real world practice.Methods a compassionate use program employing ropeg for treating patients with unmet medical need was initiated in taiwan in 2017.Herein, we collected clinical data and assessed the safety as well as efficacy of ropeg in nine patients treated in this program.Results collectively, among evaluable patients, both the molecular response and complete blood count remission rates were 62.5%.Most therapy-related side effects were mild, and there was no treatment discontinuation attributable to intolerable adverse events.The agent also showed efficacy in symptom amelioration and spleen size reduction.Although no specific patterns of cytokine level alteration could be identified, significantly attenuated plasma levels of inflammation markers were observed in one particular patient who happened to have normalized spleen size and most remarkable reduction in jak2 mutant allele burden, indicating all-around improvement in every aspect of this case.Furthermore, plasma hepcidin levels increased in two-thirds of pv patients, illustrating the potential of ropeg to restore normal regulation of erythropoiesis.Using rna sequencing on pre- and post-treatment samples from one patient, we demonstrated altered expression of genes participating in ifn response, inflammation, apoptosis, and cellular differentiation.Conclusion conclusively, observed signs of efficacy and safety in our real-world experience prove ropeg as a promising option for the treatment of mpn.

Journal: Journal of the Formosan Medical Association = Taiwan yi zhi (2021)
Publication types: Journal Article
Ensuring image integrity in the digital age.

Febs open bio and our fellow febs press journals have a strong commitment to maintaining the integrity of the scientific literature.The life sciences, in particular, are suffering from an ongoing reproducibility crisis, and this may in part be fuelled by mistakes, manipulation or outright fabrication of the presented data.We were recently made aware of several articles published in febs open bio that appear to contain full or partial duplications of images from other published articles in a different scientific context.In most of these cases, the duplications were taken from previously published papers.After thorough investigation and subsequent discussion within febs press and with wiley's integrity in publishing group, we have retracted most of these articles.

Journal: FEBS open bio (2022)
Publication types: Editorial
Size scaling of photophysiology and growth in four freshly isolated diatom species from Ryder Bay, western Antarctic peninsula.

Diatoms are one of the dominant groups in phytoplankton communities of the western antarctic peninsula (wap).Although generally well-studied, little is known about size dependent photophysiological responses in diatom bloom formation and succession.To increase this understanding, four antarctic diatom species covering two orders of magnitude in cell size were isolated in northern marguerite bay (wap).Fragilariopsis sp., pseudo-nitzschia cf.Subcurvata, thalassiosira cf.Antarctica, and proboscia cf.Alata were acclimated to three different irradiances after which photophysiology, electron transport, carbon fixation, and growth were assessed.The small species fragilariopsis sp., pseudo-nitzschia cf.Subcurvata, and large species proboscia cf.Alata showed similar photoacclimation to higher irradiances with a decrease in cellular chlorophyll a and an increase in chlorophyll a specific absorption and xanthophyll cycle pigments and activity.In contrast, pigment concentrations and absorption remained unaffected by higher irradiances in the large species thalassiosira cf.Antarctica.Overall, the small species showed significantly higher growth rates compared to the large species, which was related to relatively high light harvesting capacity and electron transport rates in the smaller species.However, photophysiological responses related to photoinhibition and photoprotection and carbon fixation showed no relationship with cell size.This study supports the dominance of small diatoms at low irradiances during winter and early spring, but does not provide photophysiological evidence for the dominance of large diatoms during the phytoplankton bloom in the wap.This suggests that other factors such as grazing and nutrient availability are likely to play a major role in diatom bloom formation.

Journal: Journal of phycology (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Fomitopsis meliaeCFA 2, a novel brown rot for endoglucanase: emphasis towards enhanced endoglucanase production by statistical approach.

Brown rot basidiomycetes are a principal group of wood-decaying fungi which degrade wood cellulose and hemicellulose by the combination of carbohydrate active enzymes and non-enzymatic oxidation reactions.Very scant information is available on carbohydrate active enzymes of brown rot fungi.In this context, present study focused on the production of cellulolytic-hemicellulolytic enzymes from newly isolated brown rot fomitopsis meliae cfa 2.Under solid-state fermentation using wheat bran as the substrate fomitopsis meliae cfa 2 was able to produce a maximum of 1391.12 ± 21.13 u/g of endoglucanase along with other cellulolytic and hemicellulolytic enzymes.Various fermentation parameters were optimised for enhanced production of endoglucanase by employing plackett-burman design followed by box-behnken design.A well-fitted regression equation with r2value of 98.91% was attained for endoglucanase.The yield of endoglucanase was enhanced by 1.83-fold after executing statistical optimisation of various fermentative parameters.The newly isolated fomitopsis meliae cfa 2 was found to be a potential producer of endoglucanase.Enzymatic saccharification of alkali-treated wheat straw and rice straw resulted in release of 190.8 and 318.8 mg/g of reducing sugars, respectively.

Journal: Mycology (2021)
Publication types: Journal Article
Quality Assessment of Hypertension Treatment-Related Information on WeChat: Cross-sectional Study.

The we chat platform has become a primary source for medical information in china.However, no study has been conducted to explore the quality of information on we chat for the treatment of hypertension, the leading chronic condition.Objective this study aimed to explore the quality of information in articles on we chat that are related to hypertension treatment from the aspects of credibility, concreteness, accuracy, and completeness.Methods we searched for all information related to hypertension treatment on we chat based on several inclusion and exclusion criteria.We used 2 tools to evaluate information quality, and 2 independent reviewers performed the assessment with the 2 tools separately.First, we adopted the discern instrument to assess the credibility and concreteness of the treatment information, with the outcomes classified into five grades: excellent, good, fair, poor, and very poor.Second, we applied the chinese guidelines for prevention and treatment of hypertension (2018 edition) to evaluate the accuracy and completeness of the article information with regard to specific medical content.Third, we combined the results from the 2 assessments to arrive at the overall quality of the articles and explored the differences between, and associations of, the 2 independent assessments.Results of the 223 articles that were retrieved, 130 (58.3%) full texts were included.Of these 130 articles, 81 (62.3%) described therapeutic measures for hypertension.The assessment based on the discern instrument reported a mean score of 31.22 (sd 8.46).There were no articles rated excellent (mean score >63); most (111/130, 85.4%) of the articles did not refer to the consequences-in particular, quality of life-of no treatment.For specific medical content, adherence to the chinese guidelines for prevention and treatment of hypertension was generally low in terms of accuracy and completeness, and there was much erroneous information.The overall mean quality score was 10.18 (sd 2.22) for the 130 articles, and the scores differed significantly across the 3 types (p=.03) and 5 sources (p=.02).Articles with references achieved higher scores for quality than those reporting none (p<.001).The results from the discern assessment and the medical content scores were highly correlated (ρ=0.58; p<.001).Conclusions the quality of hypertension treatment-related information on the we chat platform is low.Future work is warranted to regulate information sources and strengthen references.For the treatment of hypertension, crucial information on the consequences of no treatment is urgently needed.

Journal: Journal of medical Internet research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The value of four imaging modalities in diagnosing lymph node involvement in rectal cancer: an overview and adjusted indirect comparison.

Several systematic reviews have investigated the accuracy of imaging modalities for lymph node involvement of rectal cancer, but there are considerable differences in conclusions.This overview aimed to assess the methodological and reporting quality of systematic reviews that evaluated the diagnostic value of imaging modalities for lymph node involvement in patients with rectal cancer and to compare the diagnostic value of different modalities for lymph node involvement.The pub med, embase, cochrane library and chinese biomedicine literature were searched to identify relevant systematic reviews.The methodological quality was assessed using the amstar checklist, and the reporting quality was assessed using prisma-dta checklist.The indirect comparison was conducted to compare the accuracy of different imaging modalities.Seven systematic reviews involving 353 primary studies were included.The median (range) amstar scores were 6.0 (4.0-9.0); the median (range) prisma-dta scores were 18.0 (11.0-23.0).Sensitivity of mri [0.69 (95% ci 0.63, 0.77)] was significantly higher than that of erus [0.57 (95% ci 0.53, 0.62)].Specificity of erus [0.80 (95% ci 0.77, 0.83)] was significantly higher than that of ct [0.72 (95% ci 0.67, 0.78)].Positive likelihood ratio of eus [3.04 (95% ci 2.75, 3.36)] was significantly higher than that of ct [2.21 (95% ci 1.69, 2.90)].Eus had better diagnostic value than ct and erus in the diagnosis of lymph node involvement.Compared with ct and erus, mri was more sensitive.Eus and mri had comparable diagnostic accuracy, but no modality was proved to be particularly accurate.

Journal: Clinical and experimental medicine (2019)
Publication types: Comparative Study;Evaluation Study;Journal Article;Systematic Review
Implementation Science and Nursing Leadership: Improving the Adoption and Sustainability of Evidence-Based Practice.

Increasingly, nurse executives are embracing evidence-based practice (ebp).Yet, it takes 17 years to move only 14% of research evidence into practice.Implementation science (is) aims to reduce this gap through the study of factors that influence dissemination, adoption, implementation, and sustainability of evidence-based interventions.Nurse leaders aiming for ebp must be well equipped to support is.This article introduces is, leadership competencies essential for supporting implementation research and practice, and preparing an is-ready workforce.

Journal: The Journal of nursing administration (2021)
Publication types: Journal Article
Clinical Profile and Outcome in Patients of Complicated Urinary Tract Infections: A Single-Center Prospective Observational Study.

Complicated urinary tract infection (c uti) is the one which is associated with structural and functional abnormalities of the urinary tract, thus increasing the risk of infection and failure of therapy.Aim this study aims to determine the risk factors, changing trends in etiology, current treatment options, and outcomes in c uti.Materials and methods this prospective observational study was done on patients presenting with c uti.Hematological, biochemical workup, urine routine, urine culture, blood culture, ultrasonography, and wherever necessary computerized tomography of the genitourinary tract was done.The medical/surgical interventions and outcomes in these patients were recorded.Results a total of 100 patients were enrolled in the study.Diabetes mellitus was the most common risk factor present in 53%.The most common organism isolated in urine culture was escherichia coli(48%) followed by klebsiella pneumoniae(19%) and similar trend but lesser positive yield was there in blood culture (escherichia coli -26% followed by klebsiella pneumoniae -3%).The organisms were most susceptible to colistin/polymyxin (100%) followed by carbapenems (88%), and later were the most commonly used empirical antibiotics in our study, yielding 95% survival rate.Surgical interventions (percutaneous/endourological) were required in 28%, renal replacement therapy in 14%, intensive care in 40% and mechanical ventilation in 10%, with 4% overall mortality at the end of 1-month follow-up.The mean duration of hospital stay was 9.1 ± 2.7 days.Conclusion escherichia coliwas the most common organism causing c uti, with diabetes being the most common risk factor.Most of the patients were treated with carbapenems with excellent survival outcomes.

Journal: International journal of applied & basic medical research (2022)
Publication types: Journal Article
Emergency surgical decompression and long-term survival of glioblastoma presenting in coma in old age: case report and review of prognostic factors.

We present a case demonstrating that older age does not exclude long-term survival with glioblastoma.This is a malignant neoplasm with a median life expectancy of 14 months in patients treated with radical intent.Survival is dependent on several independent and interacting prognostic factors of which advancing age is a negative factor.We present a septuagenarian with a 3.5-year survival following aggressive management.The potential to improve glioblastoma survival in an elderly population by examination of additional prognostic factors and identifying biomarkers warrants further research.

Journal: Oxford medical case reports (2022)
Publication types: Case Reports;Journal Article
Surgical treatment of a giant right coronary aneurysm following coronary stent fracture.

Coronary artery aneurysm represents a challenging and potentially fatal disease.Aim and material methods we present the case of a giant right coronary artery aneurysm treated surgically after percutaneous intervention and fracture of the stent.Results and discussion the aneurism was opened and the coronary ligated proximally and distally.It was not possible to re-established continuity of the coronary artery or perform a bypass graft.An early surgical strategy would have re-established blood flow in the involved coronary artery and avoided chronic ischemia of the supplied myocardial territory.

Journal: Journal of cardiac surgery (2022)
Publication types: Case Reports;Journal Article
Mapping cell migrations and fates in a gastruloid model to the human primitive streak.

Although fate maps of early embryos exist for nearly all model organisms, a fate map of the gastrulating human embryo remains elusive.Here, we use human gastruloids to piece together a rudimentary fate map for the human primitive streak (ps).This is possible because differing levels of bmp, wnt and nodal lead to self-organization of gastruloids into homogenous subpopulations of endoderm and mesoderm, and comparative analysis of these gastruloids, together with the fate map of the mouse embryo, allows the organization of these subpopulations along an anterior-posterior axis.We also developed a novel cell tracking technique that detected robust fate-dependent cell migrations in our gastruloids comparable with those found in the mouse embryo.Taken together, our fate map and recording of cell migrations provides a first coarse view of what the human ps may resemblein vivo.

Journal: Development (Cambridge, England) (2019)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Diversity and toxicity of Pacific strains of the benthic dinoflagellate Coolia (Dinophyceae), with a look at the Coolia canariensis species complex.

Coolia meunier 1919 from benthic assemblages of hawai'i and guam were isolated and clonal cultures were established from single cells.Cultures were identified to species-level based on 28s r rna and its-5.8s r rna genes and tested for toxicity.In hawai'i, two strains of c.Malayensis were isolated.In guam, a high biodiversity was identified: four strains of c.Malayensis, one strain of c.Palmyrensis, one strain of c.Tropicalis, one strain of c.Canariensis phylogroup iii, and two strains forming a new phylogroup (phylogroup iv) of nontoxic c.Canariensis.Morphology of the new c.Canariensis phylogroup was described using light microscopy and scanning electron microscopy.Mass cultures and methanol extracts of representative cultures (c.Malayensis, c.Palmyrensis, c.Canariensis, c.Tropicalis) from guam were prepared for liquid chromatography-mass spectrometry analysis.Chemical analyses revealed yessotoxin analogue c56h78o18s2is produced by c.Malayensis, c.Canariensis phylogroup iv and c.Palmyrensis, but other analogues, c57h80o18s2and c58h86o18s2, were only found in c.Malayensis (okinawa) and c.Canariensis phylogroup iv.Individual toxin profiles were also different over time for an okinawa strain of c.Malayensis (nies-3637), highlighting intra and inter-species variation in yessotoxin-analogue expression.Biological activity was tested using artemia bioassay and toxicity was observed in guam and okinawa strains of c.Malayensis.Strong support of four distinct clades within the c.Canariensis species complex was recovered in phylogenetic analyses, despite morphological similarities.

Journal: Harmful algae (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't