syedzayyan/paper_mill_benchmark huggingface dataset:
The Effect of Temperature on Intestinal Flora Imbalance Based on Time Series Prediction Model

A series of effects caused by temperature change are the biggest problems faced by biological systems.These irregular environmental characteristics have brought new challenges to people and even animal groups.The immune function of human intestinal flora has a great protective effect on other organs and the body environment.It can help the human body carry out intestinal digestion, food absorption, nutritional metabolism, and so on.Based on the above situation, this paper uses the time series prediction model to study the factors affecting the imbalance of intestinal flora in the process of temperature change.Firstly, biological experiments are carried out with animals to simulate the human environment.Based on the sequence information of historical temperature change parameters, a temperature prediction device based on time series model is proposed.The effects of air factors and carbon dioxide content on the prediction results are evaluated by statistical analysis.Secondly, in order to ensure the accuracy of the experimental data, the neural network algorithm is used to optimize the model, and the white blood cell count is used to analyze the influence of temperature change on the intestinal flora structure of the two organisms.Finally, the experimental results are applied to the human environment to analyze the research results.The results showed that with the irregular change of temperature, the number of intestinal flora and internal colony structure also changed.The richness index in the normal temperature environment is relatively large, which can effectively explain the high richness of intestinal microflora in the experimental population.Further analyze the subjects and distinguish the animals according to sex.The number of bacteroides in the intestinal flora of male animals was higher than that of female animals, but this phenomenon disappeared immediately after physical ligation.In addition, the intestinal flora abundance of female animals is higher than that of male animals, and the metabolic level is faster.

Journal: Journal of Function Spaces (2022)
Publication types: Research Article;
A Secure Environment Using a New Lightweight AES Encryption Algorithm for E-Commerce Websites

Providing security for transmitted data through the e-commerce environment requires using a fast and high secure encryption algorithm.Balancing between the speed and the security degree is a problem that many of the encryption algorithms suffer from.Increasing the security degree requires increasing the level of complexity which results in increasing encryption time.On the other hand, increasing the algorithm speed may reduce the complexity degree which affects the security level.This paper aims to design an encryption algorithm that balances time and complexity (speed and security).This is done by suggesting a security environment that depends on creating and providing an agent software to be settled into each customer device that manages the purchase and security process without customer interference.The suggested encryption algorithm is applied within this environment.Several modifications are performed on the aes encryption algorithm.The aes was chosen due to its performance (security and speed), which makes it suitable for encrypting transmitted data over the internet.These modifications involve adding preprocessing steps (padding and zigzag), eliminating sub byte step, and reducing the number of rounds.The experimental results showed that the suggested algorithm provides more security and speed in the encryption and decryption process.The randomness degree has increased by 29.5%.The efficiency is increased because the encryption and decryption times are reduced, as is the cpu usage.The throughput for the suggested algorithm is increased by 10% for the encryption process and is increased by 9.3% for the decryption process.

Journal: Security and Communication Networks (2021)
Publication types: Research Article;
A Brief Talk on the Design of Biopharmaceutical Separation and Purification Technology Course

Biological separation and purification technology is the basic technology of modern biotechnology, which is widely used in the pharmaceutical industry, especially the biopharmaceutical industry.In recent years, the biopharmaceutical industry has had a lot of room for development in the development of science and technology in south korea, and the research on biopharmaceutical equipment and pharmaceutical technology has also achieved good research results.This article proposes a brief discussion on the design of biopharmaceutical separation and purification technology courses.In this study, by analyzing the synthesis potential of the secondary metabolites of the strain, using the α-glucosidase inhibition rate as an inspection indicator, the fermentation medium of the strain was optimized, and batch fermentation was carried out, and then, the metabolites were separated and purified, and the following conclusion was obtained: the α-glucosidase inhibition rate of the crude extract of the strain in the optimized fermentation medium is 35% higher than that of the initial medium.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Review Article;
An ECG Heartbeat Classification Method Based on Deep Convolutional Neural Network

The electrocardiogram (ecg) is one of the most powerful tools used in hospitals to analyze the cardiovascular status and check health, a standard for detecting and diagnosing abnormal heart rhythms.In recent years, cardiovascular health has attracted much attention.However, traditional doctors’ consultations have disadvantages such as delayed diagnosis and high misdiagnosis rate, while cardiovascular diseases have the characteristics of early diagnosis, early treatment, and early recovery.Therefore, it is essential to reduce the misdiagnosis rate of heart disease.Our work is based on five different types of ecg arrhythmia classified according to the aami ec57 standard, namely, nonectopic, supraventricular ectopic, ventricular ectopic, fusion, and unknown beat.This paper proposed a high-accuracy ecg arrhythmia classification method based on convolutional neural network (cnn), which could accurately classify ecg signals.We evaluated the classification effect of this classification method on the supraventricular ectopic beat (sveb) and ventricular ectopic beat (veb) based on the mit-bih arrhythmia database.According to the results, the proposed method achieved 99.8% accuracy, 98.4% sensitivity, 99.9% specificity, and 98.5% positive prediction rate for detecting veb.Detection of sveb achieved 99.7% accuracy, 92.1% sensitivity, 99.9% specificity, and 96.8% positive prediction rate.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Analysis of Cardiovascular Disease Angiography Process Based on Rough Set and Internet of Things

The angiography image enhancement technology has the potential to enhance the vascular structure in the image while suppressing the background and nonvascular structures simultaneously.This technology has the ability to enhance the result as close to the real structure of blood vessels as possible.Angiographic image processing is one of the essential contents in the field of medical image processing and analysis.However, the existing cardiovascular angiography schemes suffer from various issues.In this paper, the detection process of cardiovascular angiography is studied by combining the internet of things and rough set technology.Firstly, this paper designs the architecture design of the cardiovascular angiography process combined with the internet of things technology.Secondly, this paper uses a rough set algorithm to optimize the background noise and boundary shrinkage because of the sensitivity of the contrast background noise and boundary shrinkage.Simulation results verified the applicability and efficiency of the proposed model in the cardiovascular angiography scheme.The model has been optimized during implementation.Compared with the traditional algorithm, the same image data processing speed is significantly improved to ensure the enhancement effect.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
An Automated Data Desensitisation System Based on the Middle Platform

Built on top of a big data platform, the middle platform develops data through abstraction, sharing, and reuse capabilities to provide data products and data services for upper-level business development.While fully analysing and mining the intrinsic value of data, privacy and sensitive information in the data must also be protected, so the middle platform needs a data desensitisation system to ensure the safe and open use of data.In order to solve the problems of high usage costs, low efficiency, and lack of standardised results of desensitisation that exist in conventional data desensitisation systems, an automated desensitisation system with data assets, access control, and desensitisation strategies as the main modules is established using an adaptive method of generating dynamic desensitisation rules, combined with a security monitoring mechanism of sensitivity classification and two-level permissions.The system optimises the configuration structure to obtain stable and reliable desensitisation results and efficiently respond to diverse business needs.Users are able to get rid of complex rule management and focus on the data usage itself.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
The Effect of Microwave Ablation Combined with Anti-PD-1 Monoclonal Antibody on T Cell Subsets and Long-Term Prognosis in Patients Suffering from Non-Small-Cell Lung Cancer

This research is aimed at studying the effect of microwave ablation combined with the antiprogrammed death- (pd-) 1 monoclonal antibody on t cell subsets and long-term prognosis in patients suffering from non-small-cell lung cancer (nsclc).Methods.Employing the random number table technique, a total of 122 nsclc patients who received treatment at our hospital between may 2015 and june 2019 were selected and assigned to the observation group and the control group, and each group comprised 61 patients ( n = 61 ).While the control group received only anti-pd-1 monoclonal antibody treatment, the observation group received microwave ablation in combination with anti-pd-1 monoclonal antibody.The clinical efficacy was observed for both groups.The levels of t cell subsets (cd3+, cd4+, and cd8+), serum tumor markers (squamous cell carcinoma antigen (scca), cytokeratin ig fragment (cyfra21-1), and serum carcinoembryonic antigen (cea)), nuclear factor kappa b (nf-κb), protease c (pkc), and mitogen-activated protein kinase (mapk) m rna expression between the two groups were compared.The frequency of adverse reactions was observed in both groups.The survival time of both the groups was recorded over the course of three years of follow-up.The kaplan-meier method was employed for analyzing the survival of both the control and the observation group.Results.The response rate (rr) of the observation group (80.33%) was considerably greater in comparison to that of the control group (62.30%) ( p &lt; 0.05 ).Following treatment, the observation group’s levels of cd3+, cd4+, cd8+, scca, cy fra21-1, and cea and the m rna expressions of nf-κb, pkc, and mapk were superior to those of the control group, with statistical significances (all p &lt; 0.05 ).Between the two groups, there was no significant difference in the occurrence of adverse reactions ( p &gt; 0.05 ).The observation group had greater 1-, 2-, and 3-year survival rates (57.38%, 39.34%, and 29.51%) than the control group (32.79%, 18.03%, and 8.20%), with statistically significant differences (all p &lt; 0.05 ).Conclusion.Microwave ablation in combination with an anti-pd-1 monoclonal antibody could effectively improve the level of t cell subsets and serum tumor markers in nsclc patients, resulting in a long-term prognosis of patients with good therapeutic effect and safety.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
The Clinical Observation on PONV with the Intervention of Thumbtack Needles Combined with Chinese Medicine Ironing Therapy

This study aimed to analyze the clinical efficacy of the intervention of thumbtack needles (applicable to subcutaneous embedding) combined with chinese medicine ironing therapy on postoperation nausea and vomiting (ponv).Methods.106 patients who scheduled elective surgery were enrolled and randomized into control group and experimental group, with 53 cases in each group.The control group received modern medication, while the experimental group was given thumbtack needles combined with chinese medicine ironing therapy based on the control group.The ponv score, incidence rate, gastrointestinal hormone level, functional living index-emesis (flie), and general comfort questionnaire (gcq) of the two groups were compared.Results.After treatment, the incidence of ponv and gcq in the experimental group was observed to be remarkably lower than that in the control group ( p &lt; 0.05 ), while the levels of gastrointestinal hormones and the level in the flie of the experimental group were comparatively higher than those in the control group ( p &lt; 0.05 ).Conclusion.Thumbtack needles combined with chinese medicine ironing therapy can be utilized to reduce the incidence of ponv, to improve the level of gastrointestinal hormones, and to improve the comfort and quality of patients’ lives.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
The Clinical Efficacy of Cedilanid and Isosorbide Dinitrate plus Pericardial Dissection for Chronic Constrictive Pericarditis in the Elderly and Its Influence on Plasma Endothelin, Atrial Natriuretic Peptide, and Systemic Immune-Inflammation Index

To investigate the clinical efficacy of cedilanid and isosorbide dinitrate plus pericardial dissection for chronic constrictive pericarditis in the elderly.Methods.Ninety elderly patients with chronic constrictive pericarditis admitted to our hospital from march 2018 to october 2020 were recruited and assigned to receive either cedilanid and isosorbide dinitrate (control group a), pericardial dissection (control group b), or cedilanid and isosorbide dinitrate plus pericardial dissection (combination group) via random number table method, with 30 patients in each group.Outcome measures included plasma endothelin, atrial natriuretic peptide, system immune-inflammation indices, treatment effect, quality of life, mental state, and treatment satisfaction.Results.The combination group had significantly higher treatment satisfaction and treatment efficacy than control groups a and b ( p &gt; 0.05 ).The combination group showed the lowest levels of atrial natriuretic peptide and endothelin, followed by control group a, and group b ( p &lt; 0.001 ).The combined therapy resulted in significantly lower levels of system immunity index, lower hospital anxiety and depression scale (had) scores, and better general quality of life inventory-74 (gqoli-74) scores than those of the control group b, followed by group a ( p &lt; 0.001 ).Conclusion.Cedilanid and isosorbide dinitrate plus pericardial dissection for elderly patients with chronic constrictive pericarditis enhances the level of plasma endothelin, atrial natriuretic peptide, and systemic immune-inflammation indexes of patients and improves their quality of life, which shows great potential for clinical promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Tetramethylpyrazine Inhibits the Proliferation and Invasion of Glioma Cells by Regulating the UBL7-AS1/miR-144-3p Pathway

This work aims to investigate the effects of tetramethylpyrazine (tmp) on the proliferation, migration, and invasion of glioma cells and to analyze the regulation mechanism of tmp on the long noncoding rna ubl7-as1/mi r-144-3p pathway.Glioma cell line and normal astrocytes were collected.The expression of ubl7-as1 was detected by real-time pcr.The glioma cells were overexpressed with ubl7-as1.Cck-8 and transwell assays were used to detect cell proliferation and cell invasion ability, respectively.Bioinformatics was adopted to predict the possible regulatory mechanisms of ubl7-as1.The dual luciferase reporter gene was applied to verify the regulatory effect of rna ubl7-as1 with mi r-144-3p.Tmp inhibited the proliferation and invasion of glioma cells.Ubl7-as1 was highly expressed in glioma tissues and cells.The overexpression of ubl7-as1 promotes the cell proliferation and invasion of glioma.Ubl7-as1 can act as a sponge for mi r-144-3p in glioma cells.The overexpression of ubl7-as1 can reverse the inhibition of tmp on proliferation, migration, and invasion of glioma cells.Tmp inhibits the proliferation, migration, and invasion of glioma cells by regulating the ubl7-as1/mi r-144-3p pathway.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Tea Drinking and the Risk of Carcinoma of the Urinary Bladder: A Meta-Analysis

For evaluation of the correlation between tea drinking and the risk of carcinoma of the urinary bladder.Methods .By searching pub med, embase, and cochrane library databases, the original studies on tea drinking and carcinoma of the urinary bladder risk were collected, the data were extracted, and meta‐analysis package 5.2‐0 of r language was used for meta‐analysis.Results .This study contained 11 researches, composed of 7686 patients and 10320 controls.Tea drinking was not linked to carcinoma of the urinary bladder risk (or:1.02, 95%ci: 0.95–1.11).Conclusion .Tea drinking may not be linked to carcinoma of the urinary bladder, but more definitive results are needed from higher‐quality trials.

Journal: Evidence-Based Complementary and Alternative Medicine (2023)
Publication types: Meta-Analysis;
Systematic Evaluation of the Efficacy of Acupuncture Associated with Physical and Mental Intervention when Treating Idiopathic Tinnitus and the Improvement of Tinnitus Symptoms

To systematically evaluate the efficacy of acupuncture associated with physical and mental intervention when treating idiopathic tinnitus and the improvement of tinnitus symptoms, so as to supply evidence-based medicine for its popularization and adoption.Methods.Pub med, embase, science direct, cochrane library, china knowledge network database (cnki), china vip database, wanfang database, and china biomedical literature database (cbm) online database were searched for the controlled trial of acupuncture associated with physical and mental intervention when treating idiopathic tinnitus.The retrieval time limit is from january 2010 to march 2022.Separately, two researchers extracted the data, and according to the cochrane handbook 5.3, the bias risk of each piece of literature was assessed.The collected data were measured using rev man5.3 statistical software.Results.Finally, 5 ct articles were included in this study, with a total sample size of 282.Meta-analysis showed that the effective rate of the study group was significantly higher than that of the control group ( p &lt; 0.05 ).The scores of tinnitus disorder scale (thi) after treatment were analyzed by meta.The thi scores of the study group after treatment were significantly lower than those before treatment.Meta-analysis of the severity of tinnitus after treatment showed that the severity of tinnitus in the observation group after treatment was significantly lower than that before treatment.There is a certain publication deviation in the literature, which may be related to the heterogeneity of the research and the small number of literatures.Conclusion.On the basis of acupuncture treatment, associated with physical and mental intervention is helpful to the recovery of patients with idiopathic tinnitus, can effectively improve their clinical symptoms, and is suitable for clinical application.A popularization of this concept in clinical practice is worth considering, but further research and follow-up with a higher methodological quality and longer intervention time are needed to confirm its efficacy.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Meta-Analysis;
Systematic Evaluation of Randomized Clinical Trials of Huangqin Tang in Combination with Mesalazine for Ulcerative Colitis

To systematically evaluate the efficacy and safety of huangqin tang (hqt) combined with mesalazine for the treatment of ulcerative colitis (uc).Methods.The china knowledge network, wanfang data, vip, pub med, sino med, embase, and cochrane library databases were searched for randomized controlled trials (rcts) of uc with hqt in chinese and english.The search time was from the establishment of the database to october 2021.The included literature was evaluated for data extraction and risk of bias, efficacy and safety were evaluated using the rev man5.3 software, and the quality of evidence was evaluated using grade.Results.Six studies with a total of 565 subjects were included, and a meta-analysis showed that hqt combined with mesalazine for uc significantly improved the cure rate (rr = 1.56, 95% ci [1.23, 1.98), p = 0.0003 ) and overall efficacy rate (rr = 1.24, 95% ci [1.14, 1.35], p = 0.00001 ), which significantly reduced the clinical symptom scores; however, all had high heterogeneity.Hqt combined with mesalazine modulated the patients’ serum il-6, il-10, ig a, and ig g levels.Hqt combined with mesalazine for uc tended to reduce adverse effects; however, the difference was not statistically significant.All grade ratings of the quality of evidence were of low quality.Conclusions.Hqt combined with mesalazine in the treatment of uc significantly improved the cure rate and overall treatment efficiency and regulated the expression levels of serum il-6, il-10, ig a, and ig g.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
A Career Guidance and Career Planning Assessment Method Based on Improved Correlation Analysis

The number of college graduates in china has dramatically risen in recent years, the employment structural contradiction is evident, and the pressure on employment is gradually increasing.How to improve the employment rate of graduates and the quality of employment is an important issue at present.In order to fundamentally solve the employment problem, there are some other ways besides changing the talent cultivation mode of colleges and universities, such as carrying out career guidance work.At present, the career guidance model in china’s universities is still limited to the traditionalized guidance model, which is too consistent.In order to meet the needs of the development of the market economy and the development of students’ individuality, it is necessary to study the construction of a personalized career guidance model.This study first analyzes the current situation of career guidance work in china’s colleges and universities and puts forward the importance and necessity of building a personalized career guidance model.Subsequently, based on improved correlation analysis, this research provides a method for evaluating employee knowledge and career planning.The experimental results suggest that the proposed method can accurately assess the impact of job counseling and establish the groundwork for future job counseling and career planning work in colleges and universities.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;