syedzayyan/paper_mill_benchmark huggingface dataset:
Impaired Fasting Glucose (IFG) Prevalence Among Hypolipidemic Treatment- naïve Patients with Hypertension.

Impaired fasting glucose (ifg) predisposes to the future development of type 2 diabetes mellitus (t2dm) and may also be associated with increased cardiovascular disease (cvd) risk.Hypertension is an established cvd risk factor.Objective this study aimed to assess the prevalence of ifg and the associated anthropometric and metabolic disturbances in patients with hypertension.Methods consecutive hypertensive patients not on any hypolipidemic treatment and without a diagnosis of t2dm were included.Ifg was defined as serum glucose ≥100 mg/dl according to the american diabetes association criteria.Results the total sample consisted of 1381 participants; between them, 78 patients were diagnosed to have t2dm and they were excluded from the analyses, leaving a final sample of 1303 hypertensive patients [41.0% men; median age 58 (range: 15-90) years] not on any hypolipidemic treatment and without a diagnosis of t2dm.Ifg was identified in 469 patients (36%).Ifg was more prevalent in males than in females (42.4% vs.31.8%, p<0.001).Patients with ifg had greater body mass index (bmi), waist-to-hip ratio, systolic blood pressure, pulse pressure, triglycerides, alanine aminotransferase, gamma-glutamyl transferase, and uric acid serum levels compared with patients with normal serum glucose levels.Conclusion this study reveals that in a sample of patients with hypertension, one out of three has ifg.This is more prevalent among men.Ifg is associated with the presence of a more aggravated anthropometric and biochemical profile, possibly associated with an increased cvd risk.

Journal: Current hypertension reviews (2022)
Publication types: Journal Article
Atco, a yeast mitochondrial complex of Atp9 and Cox6, is an assembly intermediate of the ATP synthase.

Mitochondrial oxidative phosphorylation (oxphos) is the process by which the atp synthase conserves the energy released during the oxidation of different nutrients as atp.The yeast atp synthase consists of three assembly modules, one of which is a ring consisting of 10 copies of the atp9 subunit.We previously reported the existence in yeast mitochondria of high molecular weight complexes composed of mitochondrially encoded atp9 and of cox6, an imported structural subunit of cytochrome oxidase (cox).Pulse-chase experiments indicated a correlation between the loss of newly translated atp9 complexed to cox6 and an increase of newly formed atp9 ring, but did not exclude the possibility of an alternate source of atp9 for ring formation.Here we have extended studies on the functions and structure of this complex, referred to as atco.We show that atco is the exclusive source of atp9 for the atp synthase assembly.Pulse-chase experiments show that newly translated atp9, present in atco, is converted to a ring, which is incorporated into the atp synthase with kinetics characteristic of a precursor-product relationship.Even though atco does not contain the ring form of atp9, cross-linking experiments indicate that it is oligomeric and that the inter-subunit interactions are similar to those of the bona fide ring.We propose that, by providing atp9 for biogenesis of atp synthase, atco complexes free cox6 for assembly of cox.This suggests that atco complexes may play a role in coordinating assembly and maintaining proper stoichiometry of the two oxphos enzymes.

Journal: PloS one (2020)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Survival outcomes after breast-conserving therapy compared with mastectomy for patients with early-stage metaplastic breast cancer: a population-based study of 2412 patients.

Previous studies revealed that patients with early-stage metaplastic breast cancer (mbc) underwent mastectomy more often than breast-conserving therapy (bct) mainly due to the larger tumor size.This study was performed to compare the survival outcomes following bct versus mastectomy for patients with early-stage mbc.Methods surveillance, epidemiology, and end results (seer) database was used to identify women diagnosed with early-stage mbc (t1-3n0-3m0) between 2001 and 2016, who were treated with either bct or mastectomy.We assessed overall survival (os) and breast cancer-specific survival (bcss) using the kaplan-meier method and hazard ratios using cox proportional hazards models.Results a total of 2412 mbc patients were identified, 881 (36.5%) of whom underwent bct and 1531(63.5%) underwent mastectomy.The median follow-up time was 73 months.Most of patients had older age (≥50 years old), larger tumor size, higher american joint committee on cancer (ajcc) stage and hormone receptor negativity.After adjustment for confounding variables, patients who underwent bct had significantly improved os (5-year os: 84.3% vs 62.5%; 10-year os: 73.0% vs 52.1%; adjusted hr = 0.76, 95%ci: 0.59-0.97, p = 0.028) and bcss (5-year bcss: 89.1% vs 70.8%; 10-year bcss: 83.9% vs 67.5%; adjusted hr = 0.72, 95%ci: 0.53-0.96, p = 0.026) than those who underwent mastectomy, and this improvement remained significant for all t and n stages of mbc except for n2-3 stage.Conclusion bct conferred improved os and bcss compared with mastectomy for patients with early-stage mbc, and the improvement persisted in almost all of the subgroups of different t and n stages.

Journal: Breast (Edinburgh, Scotland) (2021)
Publication types: Journal Article
IL-24 Contributes to Neutrophilic Asthma in an IL-17A-Dependent Manner and Is Suppressed by IL-37.

Neutrophilic asthma is associated with asthma exacerbation, steroid insensitivity, and severe asthma.Interleukin (il)-24 is overexpressed in asthma and is involved in the pathogenesis of several allergic inflammatory diseases.However, the role and specific mechanism of il-24 in neutrophilic asthma are unclear.We aimed to elucidate the roles of il-24 and il-37 in neutrophilic asthma, the relationships with il-17a and the mechanisms regulating neutrophilic asthma progression.Methods purified human neutrophils were isolated from healthy volunteers, and a cell coculture system was used to evaluate the function of il-24 in epithelium-derived il-17a-dependent neutrophil migration.Il-37 or a small interfering rna (si rna) targeting il-24 was delivered intranasally to verify the effect in a murine model of house dust mite (hdm)/lipopolysaccharide (lps)-induced neutrophilic asthma.Results il-24 enhanced il-17a production in bronchial epithelial cells via the stat3 and erk1/2 signaling pathways; this effect was reversed by exogenous il-37.Anti-il-17a monoclonal antibodies reduced neutrophil chemotaxis induced by il-24-treated epithelial cellsin vitro.Increased il-24 and il-17a expression in the airway epithelium was observed in hdm/lps-induced neutrophilic asthma.Il-37 administration or il-24 silencing attenuated neutrophilic asthma, reducing il-17a levels and decreasing neutrophil airway infiltration, airway hyperresponsiveness, and goblet cell metaplasia.Silencing il-24 inhibited t-helper 17 (th17) immune responses, but not th1 or th2 immune responses, in the lungs of a neutrophilic asthma model.Conclusions il-24 aggravated neutrophilic airway inflammation by increasing epithelium-derived il-17a production, which could be suppressed by il-37.Targeting the il-24/il-17a signaling axis is a potential strategy, and il-37 is a potential candidate agent for alleviating neutrophilic airway inflammation in asthma.

Journal: Allergy, asthma & immunology research (2022)
Publication types: Journal Article
Antibiotics use evaluation among hospitalized adult patients at Jimma Medical Center, southwestern Ethiopia: the way to pave for antimicrobial stewardship.

An irrational antibiotic use is a common problem in developing countries like ethiopia, which makes empiric antibiotics use difficult.It is considered to be the greatest health problem in our time and future unless intervened.Therefore, this study aimed to assess the patterns of antibiotics use among hospitalized adult patients to pave the way for antimicrobial stewardship.Methods a hospital-based prospective observational study was conducted at jimma medical center, southwestern ethiopia, from 30 october 2020 to 29 january 2021 with 360 adult hospitalized patients participating.A semi-structured questionnaire and consecutive sampling technique was used for data collection.The data were collected through medical record reviews and patient interviews.The collected data were entered into epi-data and exported to spss®version 23.0 for analysis.Days of therapy (dot) and essential medicine lists "access, watch, and reserve (awa re)" antibiotics classification were used to assess antibiotic use pattern among participants.Results the majority of study participants were females (55.3%), attended formal education (59.4%), and live in rural areas (61.4%) with mean age ± (sd) of 37.65 ± (16.75).The overall rate of antibiotics consumption during the study was 111 days of therapy per 100 bed-days and about two-thirds (66%) of the prescribed antibiotics were from the "watch" group antibiotics.The indicator level of antibiotics use for "access" group antibiotics was 34% in this study based on the world health organization essential medicine list.Cephalosporins were the most commonly used class of antibiotics (93.9%).Conclusion higher antibiotics exposure and their consumption frequently observed among adult hospitalized patients in the study setting.There was a rapid increase in "watch" group antibiotics use and about two-thirds of the prescribed antibiotics were from this group.The third-generation cephalosporin were the most commonly used class of antibiotics.Generally, higher consumption and inappropriate antibiotics use among hospitalized adult patients showed the need for urgent interventions by implementing antimicrobial stewardship programs in hospitals.

Journal: Journal of pharmaceutical policy and practice (2022)
Publication types: Journal Article
Scrotal abscess as a manifestation of posterior duodenal perforation; a very rare presentation.

Posterior perforation of duodenal ulcers is very rare; the infection may spread from the retroperitoneal space to the scrotum.A 75-year-old male presented with painful right scrotal swelling for 2 days associated with fever.During abdominal examination there was abdominal tenderness and scrotal swelling and tenderness.Ct scan of the abdomen showed large amount of air collection in the retroperitoneal space extending to the right scrotum with contrast media passing to the retroperitoneum and right scrotum.Laparotomy done and there was a perforation in the posterior wall of the duodenum, suturing done and right scrotal abscess drained.

Journal: Urology case reports (2019)
Publication types: Case Reports;Journal Article
Examining Data Repository Guidelines for Qualitative Data Sharing.

Qualitative data provide rich information on research questions in diverse fields.Recent calls for increased transparency and openness in research emphasize data sharing.However, qualitative data sharing has yet to become the norm internationally and is particularly uncommon in the united states.Guidance for archiving and secondary use of qualitative data is required for progress in this regard.In this study, we review the benefits and concerns associated with qualitative data sharing and then describe the results of a content analysis of guidelines from international repositories that archive qualitative data.A minority of repositories provide qualitative data sharing guidelines.Of the guidelines available, there is substantial variation in whether specific topics are addressed.Some topics, such as removing direct identifiers, are consistently addressed, while others, such as providing an anonymization log, are not.We discuss the implications of our study for education, best practices, and future research.

Journal: Journal of empirical research on human research ethics : JERHRE (2018)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Functional connectivity of brain networks during semantic processing in older adults.

The neural systems underlying semantic processing have been characterized with functional neuroimaging in young adults.Whether the integrity of these systems degrade with advanced age remains unresolved.The current study examined functional connectivity during abstract and concrete word processing.Thirty-eight adults, aged 55-91, engaged in semantic association decision tasks during a mixed event-related block functional magnetic resonance imaging (f mri) paradigm.During the semantic trials, the task required participants to make a judgment as to whether pairs were semantically associated.During the rhyme trials, the task required participants to determine if non-word pairs rhymed.Seeds were placed in putative semantic hubs of the left anterior middle temporal gyrus (a mtg) and the angular gyrus (ag), and also in the left inferior frontal gyrus (ifg), an area considered important for semantic control.Greater connectivity between a mtg, ag, and ifg and multiple cortical areas occurred during semantic processing.Connectivity from the three seeds differed during semantic processing: the left ag and a mtg were strongly connected with frontal, parietal, and occipital areas bilaterally, whereas the ifg was most strongly connected with other frontal cortical areas and the ag in the ipsilateral left hemisphere.Notably, the strength and extent of connectivity differed for abstract and concrete semantic processing; connectivity from the left a mtg and ag to bilateral cortical areas was greater during abstract processing, whereas ifg connectivity with left cortical areas was greater during concrete processing.With advanced age, greater connectivity occurred only between the left ag and supramarginal gyrus during the processing of concrete word-pairs, but not abstract word-pairs.Among older adults, robust functional connectivity of the a mtg, ag, and ifg to widely distributed bilateral cortical areas occurs during abstract and concrete semantic processing in a manner consistent with reports from past studies of young adults.There was not a significant degradation of functional connectivity during semantic processing between the ages of 55 and 85 years.As the study focused on semantic functioning in older adults, a comparison group of young adults was not included, limiting generalizability.Future longitudinal neuroimaging studies that compare functional connectivity of young and older adults under different semantic demands will be valuable.

Journal: Frontiers in aging neuroscience (2022)
Publication types: Journal Article
The clinical significance of preoperative serum triglyceride, high-density lipoprotein, and low-density lipoprotein levels in lung squamous cell carcinoma.

To evaluate the prognostic role of the preoperative plasma lipid profile, including triglycerides (tg), total cholesterol (tc), low-density lipoprotein cholesterol (ldl-c), and high-density lipoprotein cholesterol (hdl-c) in patients with lung squamous cell carcinoma (lusc) who underwent complete resection.Clinical data, including preoperative plasma profile levels, were retrospectively collected and reviewed in 300 patients with lusc who underwent radical lung resection between 2016 and 2017.The overall survival (os) and disease-free survival (dfs) were assessed by the kaplan-meier method and the cox proportional hazards regression model.Tg ≤ 1.35, hdl-c ≤ 1.17, and ldl-c ≤ 2.32 were deemed as independent preoperative risk factors for os, and hdl-c ≤ 1.17 was an independent preoperative risk factor for dfs.In the multivariate analyses involving os and dfs, a decreased hdl-c level was significantly associated with worse os (hr, 0.546; 95% ci, 0.380-0.784, p = 0.001) and dfs (hr, 0.644; 95% ci, 0.422-0.981, p = 0.041).Additionally, an increased tg (hr, 0.546; 95% ci, 0.366-0.814, p = 0.003) or ldl-c (hr, 0.652; 95% ci, 0.456-0.933, p = 0.019) level was significantly associated with better os.In patients with lusc, decreased levels of hdl-c may predict worse outcomes for both dfs and os, while increased tg or ldl-c levels may predict better os.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The Use of Heptamethine Cyanine Dyes as Drug-Conjugate Systems in the Treatment of Primary and Metastatic Brain Tumors.

Effective cancer therapeutics for brain tumors must be able to cross the blood-brain barrier (bbb) to reach the tumor in adequate quantities and overcome the resistance conferred by the local tumor microenvironment.Clinically approved chemotherapeutic agents have been investigated for brain neoplasms, but despite their effectiveness in peripheral cancers, failed to show therapeutic success in brain tumors.This is largely due to their poor bioavailability and specificity towards brain tumors.A targeted delivery system might improve the efficacy of the candidate compounds by increasing the retention time in the tumor tissue, and minimizing the numerous side effects associated with the non-specific distribution of the chemotherapy agent.Heptamethine cyanine dyes (hmcds) are a class of near-infrared fluorescence (nirf) compounds that have recently emerged as promising agents for drug delivery.Initially explored for their use in imaging and monitoring neoplasms, their tumor-targeting properties have recently been investigated for their use as drug carrier systems.This review will explore the recent developments in the tumour-targeting properties of a specific group of nirf cyanine dyes and the preclinical evidence for their potential as drug-delivery systems in the treatment of primary and metastatic brain tumors.

Journal: Frontiers in oncology (2021)
Publication types: Journal Article;Review
Prevalence of Self-Reported Muscle Pain Among Statin Users From National Guard Hospital, Riyadh.

Statin, a hydroxymethylglutaryl-coenzyme a reductase inhibitor, is one of the commonly used lipid-lowering drugs that is used for lowering lipid levels in the body.Muscle pain is a commonly reported adverse effect of statins, yet little is known about the prevalence of muscle pain and statin use in the general population.Methods the cross-sectional study was conducted in national guard hospital, riyadh, saudi arabia.All study subjects were adult statin users aged 18 years old or above.A total of 313 patients were included in the study.The study was conducted based on a questionnaire distributed among patients according to inclusion and exclusion criteria.Results among 313 statin users, patients underwent cardiac catheterization (39, 12.5%), stress test (62; 19.8%), percutaneous coronary intervention (three; 1.0%), and coronary artery bypass graft (six, 1.9%), while 203 patients didn't have any intervention (64.9%).Most of the study subjects were on atorvastatin (139; 44.4%).The prevalence of muscle pain was 73.5%; 95% ci = (68.4% - 78.1%).The most common sites of pain were lower limb pain (160; 51.1%), upper limb pain (145; 46.3%), and trunk pain (96; 30.7%).The common types of pain were joint pain (52; 16.6%), muscle weakness (51; 16.3%), muscle aches (43; 13.7%), and muscle cramps (41; 13.1%); and patients who reported that they stopped statin at some point because of muscle pain were 92 (29.4%).Conclusion statins are important for managing and preventing ischemic heart diseases.Our study found that muscle pain is highly associated with statin use with a prevalence of 73.5%, which causes many patients to tend to stop taking their medication.Therefore, preventing the side effects by adjusting the proper dose or switching to another type of statin for high-risk patients will help them to continue using the drug.Also, it is important to rule out secondary causes of myopathy such as physical activity, fracture, thyroid dysfunction, or infection.

Journal: Cureus (2022)
Publication types: Journal Article
Differences Between Autistic and Non-Autistic Adults in the Recognition of Anger from Facial Motion Remain after Controlling for Alexithymia.

To date, studies have not established whether autistic and non-autistic individuals differ in emotion recognition from facial motion cues when matched in terms of alexithymia.Here, autistic and non-autistic adults (n = 60) matched on age, gender, non-verbal reasoning ability and alexithymia, completed an emotion recognition task, which employed dynamic point light displays of emotional facial expressions manipulated in terms of speed and spatial exaggeration.Autistic participants exhibited significantly lower accuracy for angry, but not happy or sad, facial motion with unmanipulated speed and spatial exaggeration.Autistic, and not alexithymic, traits were predictive of accuracy for angry facial motion with unmanipulated speed and spatial exaggeration.Alexithymic traits, in contrast, were predictive of the magnitude of both correct and incorrect emotion ratings.

Journal: Journal of autism and developmental disorders (2022)
Publication types: Journal Article
Overlapping Transcriptional Profile in Proton Pump Inhibitor Responsive and Nonresponsive Eosinophilic Esophagitis.

Introduction we compared esophageal mucosal gene transcript expression in proton pump inhibitor (ppi) responsive (ppi-r) eosinophilic esophagitis (eo e), ppi nonresponsive (ppi-nr) eo e, and healthy controls.Methods transcript expression in midesophagus biopsies was determined using nano string and a custom panel of eo e-specific genes.The top upregulated and downregulated genes with ≥2-fold difference in expression and statistically significant ( p < 0.05) were identified.Results nearly all the top upregulated (17 of 20) and downregulated (5 of 5) genes in eo e, compared with healthy controls, were shared between the ppi-r and ppi-nr groups.Discussion esophageal mucosal transcript expressions are remarkably similar in ppi-r eo e and ppi-nr eo e compared with healthy controls.

Journal: Clinical and translational gastroenterology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Machiavellianism and learning-related subjective well-being among Chinese senior high school students: A moderated mediation model.

Based on the life history theory and broadening construction theory, the study aimed to investigate the influence of machiavellianism on the learning-related subjective well-being and the underlying mechanism, 582 chinese senior high school students (16.8 ± 0.9 years old) including 289 girls (48.3%) and 310 boys were recruited to participate in this study, and they anonymously filled out questionnaires regarding machiavellianism, learning-related subjective well-being, gratitude, and subjective family economic level.The results showed that: (1) a higher level of machiavellianism was associated with a lower level of learning-related subjective well-being; (2) gratitude partially mediated the relationship between machiavellianism and learning-related subjective well-being; (3) subjective family economic level moderated the links between machiavellianism and learning-related subjective well-being, and between gratitude and learning-related subjective well-being.This study explained how and when machiavellianism affected chinese senior high school students' learning-related subjective well-being and provided a deeper understanding of the relationship between machiavellianism and learning-related subjective well-being.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article
The Chronically Blocked Ear - A dive into external auditory exostosis.

Numerous papers have reported the presence of reactive but benign bony exostosis in the external auditory canal of swimmers; of both cold and warm water.This outgrowth may lead to stenosis of the canal with associated complications such as repeated cerumen impaction, infections and also hearing loss.In this case report, we will present the case of a 62-year-old gentleman who was referred for imaging by an ent specialist following difficulty with visualisation of the tympanic membrane during otoscopy.

Journal: BJR case reports (2022)
Publication types: Case Reports;Journal Article