syedzayyan/paper_mill_benchmark huggingface dataset:
Hyperbolic Dispersion Arising from Anisotropic Excitons in Two-Dimensional Perovskites.

Excitations of free electrons and optical phonons are known to permit access to the negative real part of relative permittivities (ε^{'}<0) that yield strong light-matter interactions.However, negative ε^{'} arising from excitons has been much less explored.Via development of a dielectric-coating based technique described herein, we report fundamental optical properties of two-dimensional hybrid perovskites (2dhps), composed of alternating layers of inorganic and organic sublattices.Low members of 2dhps (n=1 and n=2) exhibit negative ε^{'} stemming from the large exciton binding energy and sizable oscillator strength.Furthermore, hyperbolic dispersion (i.e., ε^{'} changes sign with directions) occurs in the visible range, which has been previously achieved only with artificial metamaterials.Such naturally occurring, exotic dispersion stems from the extremely anisotropic excitonic behaviors of 2dhps, and can intrinsically support a large photonic density of states.We suggest that several other van der waals solids may exhibit similar behaviors arising from excitonic response.

Journal: Physical review letters (2018)
Publication types: Journal Article
Genome-Based Exploration ofRhodococcusSpecies for Plastic-Degrading Genetic Determinants Using Bioinformatic Analysis.

Plastic polymer waste management is an increasingly prevalent issue.In this paper,rhodococcusgenomes were explored to predict new plastic-degrading enzymes based on recently discovered biodegrading enzymes for diverse plastic polymers.Bioinformatics prediction analyses were conducted using 124 gene products deriving from diverse microorganisms retrieved from databases, literature data,omic-approaches, and functional analyses.The whole results showed the plastic-degrading potential of rhodococcusgenus.Among the species with high plastic-degrading potential,r.erythropolis,r.equi,r.opacus,r.qingshengii, r.fascians, and r.rhodochrousappeared to be the most promising for possible plastic removal.A high number of genetic determinants related to polyester biodegradation were obtained from different rhodococcusspecies.However, score calculation demonstrated that rhodococcusspecies (especially r.pyridinivorans,r.qingshengii, and r.hoagii) likely possess pe-degrading enzymes.The results identified diverse oxidative systems, including multicopper oxidases, alkane monooxygenases, cytochrome p450 hydroxylases,para-nitrobenzylesterase, and carboxylesterase, and they could be promising reference sequences for the biodegradation of plastics with c-c backbone, plastics with heteroatoms in the main chain, and polyesters, respectively.Notably, the results of this study could be further exploited for biotechnological applications in biodegradative processes using diverse rhodococcusstrains and through catalytic reactions.

Journal: Microorganisms (2022)
Publication types: Journal Article
Low Sensitivity of Admission Lung US Compared to Chest CT for Diagnosis of Lung Involvement in a Cohort of 82 Patients with COVID-19 Pneumonia.

And objectives: the potential role of lung ultrasound (lus) in characterizing lung involvement in coronavirus disease 2019 (covid-19) is still debated.The aim of the study was to estimate sensitivity of admission lus for the detection of sars-co v-2 lung involvement using chest-ct (computed tomography) as reference standard in order to assess lus usefulness in ruling out covid-19 pneumonia in the emergency department (ed).methods: eighty-two patients with confirmed covid-19 and signs of lung involvement on chest-ct were consecutively admitted to our hospital and recruited in the study.Chest-ct and lus examination were concurrently performed within the first 6-12h from admission.Sensitivity of lus was calculated using ct findings as a reference standard.results: global lus sensitivity in detecting covid-19 pulmonary lesions was 52%.Lus sensitivity ranged from 8% in case of focal and sporadic ground-glass opacities (mild disease), to 52% for a crazy-paving pattern (moderate disease) and up to 100% in case of extensive subpleural consolidations (severe disease), although lus was not always able to detect all the consolidations assessed at chest-ct.Lus sensitivity was higher in detecting a typical chest-ct pattern (60%) and abnormalities showing a middle-lower zone predominance (79%).conclusions: as admission lus may result falsely negative in most cases, it should not be considered as a reliable imaging tool in ruling out covid-19 pneumonia in patients presenting in ed.It may at least represent an expanded clinical evaluation that needs integration with other diagnostic tests (e.g., nasopharyngeal swab, chest-ct).

Journal: Medicina (Kaunas, Lithuania) (2021)
Publication types: Journal Article
Effect of COVID-19 on the Activity Level of Elderly people with Dementia.

Measures against physical and social frailty after the covid-19 epidemic in elderly people with dementia are required.However, there are no studies that have systematically examined the level of activity maintained by elderly people with dementia.In this study, we developed an ict-based steps monitoring system and investigated changes in the number of steps taken by 13 community-dwelling elderly people with dementia from before the covid-19 epidemic to during the epidemic.Six of the thirteen subjects maintained approximately 7,000 steps, which was the same level as that before the epidemic.However, some subjects showed a significant decrease in their frequency of going out.This system indicated the construction of a health promotion strategy based on quantitative daily step count data for community-dwelling elderly people with dementia.

Journal: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference (2023)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Controllable synthesis of nitrogen-doped carbon containing Co and Co3Fe7nanoparticles as effective catalysts for electrochemical oxygen conversion.

Sufficient and well-distributed active sites and highly conductive carbon matrix are two important factors to achieve highly efficient electrocatalysts.In this study, we report an adjusted metal-organic frameworks (mof)-based route for the preparation of nitrogen-doped fe/co bimetallic electrocatalysts.With suitable fe/co molar ratio (fe/co = 1/4.15), co nanoparticles (nps) with mild oxidation state and co3fe7alloys wrapped with thin graphene layers are embedded in an integrated and continuous carbon network.The corresponding fc@ncs-4.15 catalyst exhibits excellent oxygen reduction reaction (orr) activity (onset potential (eonset) of 0.94 v and half-wave potential (e1/2) of 0.84 v vs rhe) in alkaline medium, close to commercial pt/c and superior to the other two fc@ncs.The desirable orr performance results from the uniform distribution co3fe7active sites, electron density modification from co nps to surrounding carbon layers, hierarchical pore structure with large surface area, low carbon content, high pyridinic and graphitic n components.The fc@ncs-4.15 also displays satisfactory methanol crossover tolerance and durability.

Journal: Journal of colloid and interface science (2021)
Publication types: Journal Article
Genotoxicity assessment of food-flavoring chemicals used in Japan.

We assessed the genotoxicity of 30 food-flavoring chemicals used in japan that have not been investigated before.These 30 food-flavoring chemicals have representative chemical structures belonging to 18 chemical classes.The ames and chromosomal aberration (ca) tests (in vitrotests) were first conducted in accordance with the "food additive risk assessment guidelines" of the japan food safety commission.If thein vitrotest yielded a positive result, anin vivomicronucleus test or a transgenic mouse gene mutation assay was performed to verify thein vitrotest results.Of the 30 food-flavoring chemicals, 3 yielded a positive result in both ames and ca tests.Another 11 chemicals yielded positive results in the ca test.However, none of the chemicals yielding positivein vitrotest results yielded positive results in thein vivotests.These findings indicate no genotoxicity concerns of the food-flavoring chemicals belonging to the abovementioned 18 chemical classes used in japan unless there are other structural modifications.

Journal: Toxicology reports (2022)
Publication types: Journal Article
Pullout strength of connected pins in hand surgery: Effect of pin diameter and insertion angle.

The purpose of this study was to examine the effect of insertion angles on the pullout strength of connected pins using a synthetic model simulating a hand bone.Material and methods the material consisted of sawbones® (20 mm×20 mm × 60 mm), fixation pins secured to a connecting rod much like an external fixator, an electric drill (speed 1,290 rpm) and a tensile testing machine.The sawbones® were drilled with different pin diameters (1.2 mm, 1.5 mm, and 1.8 mm) and insertion angles (100°, 110° and 120°).A vertical displacement of 1 mm/min was applied until the pins were extracted (maximum force).Results the pullout strength increased with the insertion angle of the connected pins.It also increased with their diameter.Regardless of the pin diameter, the load-displacement curve during the pullout test had 4 sections (peak 1, ascending slope, peak 2, descending slope) that corresponded to the combined frictional force and contact force between the pins and sawbones®.Discussion our study findings showed that, theoretically, for wrist or hand fractures treated with connected pins, the larger the diameter and insertion angle, the better the mechanical holding power of the pins.Level of evidence i, experimental study.

Journal: Orthopaedics & traumatology, surgery & research : OTSR (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Suicide Possibility Scale Detection via Sina Weibo Analytics: Preliminary Results.

Suicide, as an increasingly prominent social problem, has attracted widespread social attention in the mental health field.Traditional suicide clinical assessment and risk questionnaires lack timeliness and proactivity, and high-risk groups often conceal their intentions, which is not conducive to early suicide prevention.In this study, we used machine-learning algorithms to extract text features from sina weibo data and built a suicide risk-prediction model to predict four dimensions of the suicide possibility scale-hopelessness, suicidal ideation, negative self-evaluation, and hostility-all with model validity of 0.34 or higher.Through this method, we can detect the symptoms of suicidal ideation in a more detailed way and improve the proactiveness and accuracy of suicide risk prevention and control.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Patient Education and Sacubitril/Valsartan: A Randomized Comparative Trial.

To compare video to pharmacist education for patients taking sacubitril/valsartan.methods:we conducted a randomized controlled trial comparing video to pharmacist education with a second randomized intervention of education delivered through text or phone call at 14 days.The primary outcome compared the change in short term knowledge between groups and the secondary outcome was long term knowledge at 1 month.results:forty-three patients were included.Scores improved significantly (p< .05) in the pharmacist group from 54.1% to 85.9% and from 64.3% to 86.1% in the video education group, although there was no difference between groups (31.8% vs 22.9%,p= .13).At 30 days, scores were significantly higher than baseline (difference 16.5%,p< .05) although did decrease from the posttest (difference 7.4%,p< .05).There was no difference at 30 days between those that received text messages versus phone calls (-10% vs -5.5%, respectively;p= .36).conclusion:we saw improvements in both short term and long term knowledge for patients receiving education through pharmacist or video education.Neither approach was more effective than the other.Clinicians can use either approach based on patient preference.

Journal: Hospital pharmacy (2022)
Publication types: Journal Article
COVID-19 Vaccination Willingness and Vaccine Uptake among Healthcare Workers: A Single-Center Experience.

Healthcare workers (hcws) are at higher risk of developing covid-19 due to their professional exposition to the sars-co v-2 virus.This study assesses the intention of vaccination against covid-19 before the vaccines were approved, and the rate of vaccine uptake during the first nine months of immunization among hcws.A cross-sectional seroprevalence study was carried out during july 2020 in university clinical hospital center bezanijska kosa in belgrade, serbia that included 62.8% of all hcws.Besides serological testing for ig g antibodies, data about hcws' intention to accept covid-19 vaccination if a vaccine became available were collected.This cohort of hcws was followed up until the end of october 2021 to assess the number of vaccinated and pcr-positive staff.In the cross-sectional study, 18.3% hcws had positive sars-co v-2 ig g antibodies without difference with ig g-negative hcws regarding age, gender, profession type, and years of service.Before vaccines became available, a significantly higher percentage of ig g-positive hcws compared to ig g-negative hcws was unsure whether to be vaccinated (62.5% vs.49.0%), and significantly fewer stated that they would not be vaccinated (16.7% vs.25.1%).When the vaccines became available in serbia, among ig g-negative hcws, those who stated clear positive (yes) and clear negative (no) attitude toward vaccination before the immunization period had begun were vaccinated at 28% and 20%, respectively, while 51% of unsure hcws received a vaccine (p= 0.006).Among ig g-positive hcws, there was no statistical difference in vaccine uptake regarding those with previous negative, positive, and unsure opinions about vaccination (p= 0.498).In multivariate analysis, independent factors associated with uptake were being female (or = 1.92; 95%ci: 1.04-3.55), age of 30-59 years, previously vaccine-unsure (or = 1.84; 95%ci: 1.04-3.25), and those with previous positive vaccine attitudes (or = 2.48; 95%ci:1.23-5.01), while nurses were less likely to become vaccinated (or = 0.39 95% ci: 0.20-0.75) these findings indicate a positive change in attitudes of hcws towards covid-19 vaccination.

Journal: Vaccines (2022)
Publication types: Journal Article
Preconception period in women and men undergoing Assisted Reproduction: A gender approach for reproductive health.

To evaluate lifestyle and risk factors playing a role in increasing the burden of cardiovascular diseases and to increase attention of clinicians who should envision a broader preconception approach in art, not only in women but also in men.Study design in this cross-sectional study we investigated 90 caucasian couples, referred to the internal medicine clinic at the assisted reproductive technology centre, in order to better define in preconceptional period their cardiovascular risk profile, based on metabolic parameters and lifestyle behaviours.Results we observed two-fold increase of overweight in men in comparison to women (p = 0.006).Values of waist ≥ 94 cm in men and ≥ 80 cm in women were present in 53.3% of men and 32.2% of women (p = 0.007).Similarly, values of whr according to gender cut-off, were present in 64.4% of men and in 32.2% of women (p < 0.0001).In men we observed a significantly higher prevalence of hypertension (p = 0.02), significantly lower hdl-c (p = 0.001) and higher levels of total cholesterol (p = 0.01), ldl-c and triglycerides (p = 0.001).Sedentary behaviour was observed in about 60% of both genders.Alcohol consumption was reported by 42.2% of men and 26.7% of women (p = 0.04) and smokers were more prevalent among women (26.7%) than men (24.4%).We observed a lower adherence to mediterranean diet related to consumption of red meat and meat products (p = 0.02), as well as of legumes consumption (p = 0.01) in men, whereas sweet/pastries (p = 0.05) and fruits (p = 0.06) in women.Men and women with normal bmi, waist and whr, showed a higher mediterranean diet adherence in comparison to overweight/obese study population(p < 0.001).Finally, higher education level predicted the higher mediterranean diet adherence in both gender (p = 0.01 for men, p = 0.03 for women).Conclusions this study paid attention on preconceptional health in couples planning art.Women have a greater biological role in childbearing, whereas the role of men is underestimated.The need to conceive through art offers a window of opportunity not only to evaluate cardiovascular profile and lifestyle factors in couples prior to conception, but also to manage comorbidities and promote health behaviours in order to improve fertility and health outcomes in both women and men at short and long-term.

Journal: European journal of obstetrics, gynecology, and reproductive biology (2022)
Publication types: Journal Article
Clinical trials in Bosnia and Herzegovina: Challenges and future perspectives.

Clinical trials (cts) are research investigations in which participants receive medical treatments, interventions, or tests to assess their safety and efficacy.Each planned clinical is registered through local or national medical agencies, which may differ in the amount of administrative and legal procedures.The objective of this study was to systematically analyze the registration process for clinical trials in bosnia and herzegovina in comparison to other balkan countries.Methods the search strategy was based using two online databases: clinicaltrials.gov (ctgr) and cortellis clinical trials intelligence (c ti).Search engines included studies until 26th april 2021 and countries were compared in terms of the number of studies, status, type, funding, clinical phases and demographic data.Results the total number of clinical trials from bosnia and herzegovina recorded in the ctgr database was 219, while the c ti database comprised 254 registered studies.The total number of reported clinical trials in ctgr and c ti databases were highest in serbia (n = 1229, n = 1438), followed by croatia (n = 1142, n = 1300), and slovenia (n = 801, n = 948), respectively.However, the highest number of clinical trials per capita is in slovenia (3.85e-4 in ctgr; 4.56e-4 in c ti), followed by croatia (2.78e-4 in ctgr; 3.17e-4 in c ti), serbia (1.41e-4 in ctgr; 1.65e-4 in c ti), and bosnia and herzegovina (0.67e-4 ctgr; 0.78e-4 c ti).Conclusion our analysis showed that bosnia has the lowest number of clinical trials in the balkans.Furthermore, the registration process is complex and longer than in developed countries.Since the healthcare system has been in a transition in the past decade, clinical trials are underutilized as a tool for the improvement of patient care.The clinical trial registration process could be improved by establishing an ethical committee at the state level and by enabling a parallel submission process to ethical committees and databases.

Journal: Contemporary clinical trials communications (2022)
Publication types: Journal Article
Hypotensive Anesthesia Combined with Tranexamic Acid Reduces Perioperative Blood Loss in Simultaneous Bilateral Total Hip Arthroplasty: A Retrospective Cohort Study.

To assess the efficacy and safety of hypotensive anesthesia (ha) combined with tranexamic acid (txa) for reducing perioperative blood loss in simultaneous bilateral total hip arthroplasty (sbtha).Methods in this retrospective cohort study, a total of 183 eligible patients (15 females and 168 males, 44.01 ± 9.29 years old) who underwent sbtha from january 2015 to september 2020 at our medical center were enrolled for analysis.Fifty-nine patients received standard general anesthesia (std-ga group), the other 85 and 39 patients received ha with an intraoperative mean arterial pressure between 70 and 80 mm hg (70-80 ha group) and below 70 mm hg (<70 ha group), respectively.Txa was administrated to all patients.Perioperative blood loss (total, dominant, and hidden), transfusion rate and volume, hemoglobin and hematocrit reduction, duration of operation and anesthesia, length of hospitalization, range of hip motion as well as postoperative complications were collected from hospital's electronic records and compared between groups.Results all patients were followed for more than 3 months.Total blood loss in the two ha groups (1390.25 ± 595.67 ml and 1377.74 ± 423.46 ml, respectively) was significantly reduced compared with that in std-ga group (1850.83 ± 800.73 ml, p < 0.001).Both dominant and hidden blood loss were dramatically decreased when ha was applied (both p < 0.001).Accordingly, the transfusion rate along with volume in 70-80 ha group (14.1%, 425.00 ± 128.81 ml) and <70 ha group (12.8%, 340.00 ± 134.16 ml) were reduced in comparison with those in std-ga group (37.3%, 690.91 ± 370.21ml; p = 0.001 and p = 0.014, respectively).The maximal hemoglobin and hematocrit reduction in both ha groups were significantly less than those in std-ga group (both p < 0.001).Of note, 70-80 and <70 ha groups exhibited comparable efficacy with no significant differences between them.Besides, significant difference in duration of surgery was found among groups (p = 0.044 and p < 0.001), while no differences in anesthesia time and postoperative range of hip motion were observed.Regarding complications, the incidence of both acute kidney injury and postoperative hypotension in <70 ha group was significantly higher than that in 70-80 ha and std-ga groups (p = 0.014 and p < 0.001).Incidence of acute myocardial injury was similar among groups (p = 0.099) and no other severe complications or mortality were recorded.Conclusion the combination of ha with a mean arterial pressure (map) of 70-80 mm hg and txa could significantly reduce blood loss and transfusion during sbtha, in addition to shortening operation time and length of hospitalization, and with no increase in complications.

Journal: Orthopaedic surgery (2022)
Publication types: Journal Article
Immune Responses Against SARS-CoV-2 WT and Delta Variant in Elderly BNT162b2 Vaccinees.

Residents of nursing homes are one of the most vulnerable groups during the severe acute syndrome coronavirus 2 (sars-co v-2) pandemic.The aim of this study was to characterize cellular and humoral immune responses in >70-year-old participants before vaccination, after first and second vaccination with bnt162b2, in contrast to second-dose-vaccinated participants younger than 60 years.Methods peripheral blood mononuclear cells of 45 elderly and 40 younger vaccinees were analyzed by ifnγ elispot, specific immunoglobulin g antibody titers against sars-co v-2 spike protein, and neutralization abilities against sars-co v-2 wild-type (wt) and delta variant (b.1.617.2).Results our results clearly demonstrate a significantly increased t cell response, ig g titers, and neutralization activities against sars-co v-2 wt and delta between first and second vaccination with bnt162b2 in elderly vaccinees, thereby highlighting the importance of the second booster.Interestingly, similar cellular and humoral immune responses against sars-co v-2 wt and delta were found after the second vaccine dose in the young and elderly groups.Conclusions our data demonstrate a full picture of cellular and humoral immune responses of bnt162b2-vaccinees in two age cohorts.In all vaccines, sars-co v-2 wt-specific antibodies with similar neutralizing activity were detected in all vaccinees.After the second vaccination, neutralization titers against sars-co v-2 delta were impaired in both age groups compared with sars-co v-2 wt, thereby emphasizing the need for an additional booster to overcome rising variants of sars-co v-2.

Journal: Frontiers in immunology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't