syedzayyan/paper_mill_benchmark huggingface dataset:
The Long-Term Change of Arrhythmias after Transcatheter Closure of Perimembranous Ventricular Septal Defects

S.To observe and analyze the long-term change of different types of arrhythmias after transcatheter closure of perimembranous ventricular septal defect (pm vsd).Methods.We retrospectively collected the data of patients who underwent pm vsd closure in our institution from march 2002 to december 2010.Results.One hundred thirty-nine patients met the inclusion criteria, of which 265 (25.5%) had early arrhythmia.They were classified into two categories: conduction abnormality (191/1039; 18.4%) and origin abnormality (94/1039; 9.0%), including 20 patients with both types of arrhythmias.The median follow-up time was 84.5 months, and 103 patients (103/191; 53.9%) with early conduction block got permanent arrhythmias, while only three patients (3/94; 3.2%) with early anomalous origin arrhythmias still had an abnormal electrocardiogram.Serious arrhythmias (28/1039; 2.7%), including ii° atrioventricular block (avb), iii° avb, and complete left bundle branch block (clbbb), can appear immediately in the early postoperative period (21 patients) or in the late outset (seven patients) after several months or even years (6 months to 8.3 years).Twenty patients (20/21; 95.2%) with serious arrhythmia in the early postoperative period improved after early treatment, but six patients relapsed or worsened during follow-up.At the endpoint, severe arrhythmia persisted in 13 patients, of which four patients got permanent pacemaker implanted, and one patient with recurrent clbbb died from heart failure.Conclusions.The probability of delayed cavb or bundle branch block after vsd closure is low but often occurs several years after surgery.Therefore, long-term ecg follow-up should last for several years or even decades.Serious arrhythmias that appear early after transcatheter pm vsd closure may impose a risk of recurrence although they have been cured already.Close attention should be paid to the changes of cardiac function in patients with clbbb after vsd closure, and the severity of such arrhythmia should be taken seriously and reexamined.

Journal: Cardiology Research and Practice (2021)
Publication types: Clinical Study;
Clinical Study on Long-Term Sinus Reversion Rate and Left Atrial Function Recovery of Mitral Valve Disease with Atrial Fibrillation under Modified Surgical Radiofrequency Ablation

We aimed to study the long-term sinus reversion rate and recovery of left atrial function after modified surgical radiofrequency ablation for permanent atrial fibrillation caused by mitral valve disease.From march 2014 to may 2020, 35 patients who underwent modified surgical radiofrequency ablation during cardiac valve surgery in our hospital were selected as the study group, and 25 normal individuals without cardiac structural changes were selected as the control group.The time of modified surgical radiofrequency ablation and long-term sinus reversion rate were measured, and left atrial anteroposterior, superoinferior, left and right diameters, left atrial ejection fraction, left atrial filling index, and left atrial ejection force were measured before and 6 months after surgery.The mean ablation time was 23.2 min, and the long-term sinus reversion rate was 80.0%.The left atrium diameter decreased and the left atrium ejection fraction increased after the operation ( p &lt; 0.05 ).The left atrium filling index and ejection force were significantly increased in 28 patients with sinus reversion ( p &lt; 0.05 ).The decrease in left atrial diameter and the increase in left atrial ejection fraction were correlated with sinus conversion after surgery ( p &lt; 0.05 ).The modified operation is simple, the curative effect is definite, and the sinus reversion rate is high, which is beneficial to the restoration of left atrial structure, ejection function, and hemodynamic function.

Journal: Cardiology Research and Practice (2021)
Publication types: Clinical Study;Research Article;
Efficacy of Low Molecular Heparin on Preeclampsia by Inhibiting Apoptosis of Trophoblasts via the p38MAPK Signaling Pathway

To explore the efficacy of low molecular heparin on preeclampsia by inhibiting apoptosis of trophoblasts via the p38mapk signaling pathway.Methods.A preeclampsia rat model was established, and the effects of low molecular heparin on preeclampsia via the p38mapk signaling pathway were analyzed based on intervention of the rats with different combinations of low molecular heparin and p38mapk signaling pathway activator.Furthermore, a hypoxia/reoxygenation model of trophoblasts in vitro was established to explore the effects of low molecular heparin on trophoblasts via the p38mapk signaling pathway.Results.After treatment with low molecular heparin, pregnant rats in the heparin group showed significantly decreased blood pressure, 24 h proteinuria, and p38mapk protein levels in placenta tissues and decreased apoptosis rate of placenta tissue cells (all p &lt; 0.05 ) and showed more fetal rats and lowered weight of them (both p &lt; 0.05 ) but showed no significant change in the weight of placenta (all p &gt; 0.05 ).Pregnant rats treated with low molecular heparin and p38mapk activator showed significantly higher blood pressure, 24 h proteinuria, and p38mapk protein levels in placenta tissues and apoptosis rate of placenta tissue cells than those of pregnant rats in the heparin group (all p &lt; 0.05 ) and also showed less fetal rats and lighter fetal rats than those in the heparin group (both p &lt; 0.05 ) but showed no difference with them in the weight of placenta ( p &gt; 0.05 ).Further analysis revealed that low molecular heparin could protect the survival and migration of trophoblasts under hypoxia/reoxygenation conditions and reduce apoptosis of them (all p &lt; 0.05 ).Conclusion.Low molecular heparin can alleviate preeclampsia by inhibiting the p38mapk signaling pathway and can inhibit apoptosis of trophoblasts and promote proliferation and migration of them.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
Implications of Ezetimibe in Combination with Low- to Moderate-Intensity Atorvastatin Adjuvant Aspirin Therapy for Cerebrovascular Disease

To analyze the significance of ezetimibe in combination with low- to moderate-intensity atorvastatin adjuvant aspirin therapy for cerebrovascular disease.Methods.110 patients with cerebrovascular disease treated in our hospital from june 2020 to june 2021 were selected and divided into 55 patients in the control group and 55 patients in the study group according to the lottery method.After a comprehensive examination, patients in the two groups should be given aspirin for treatment; the control group was treated with conventional dose of atorvastatin on top of the above, and the study group was given ezetimibe and medium-low-dose atorvastatin on top of aspirin treatment, activities of daily living (adl) score, carotid artery intima-media thickness, lipid level, coagulation level, clinical effect, and adverse rate of the two groups which were tested and compared.Results.After treatment, adl score, high-density leptin cholesterol (hdl-c), and atiii levels increased, while carotid artery media thickness, triglyceride (tg), total cholesterol (tc), low-density leptin cholesterol (ldl-c), dd, pc, and hs-crp levels decreased ( p &lt; 0.05 ).After treatment, adl score, hdl-c, and atiii levels were higher in the study group.The levels of carotid media thickness, tg, tc, ldl-c, dd, pc, and hs-crp were significantly lower ( p &lt; 0.05 ).The clinical effect of the study group was outstanding ( p &lt; 0.05 ).The defect rate of the study group was lower than that of the control group, but there was no difference ( p &lt; 0.05 ).Conclusion.Ezetimibe combined with medium- and low-intensity atorvastatin with aspirin in the treatment of cerebrovascular diseases can effectively improve the coagulation function of patients, reduce the level of inflammatory factors in patients, and improve the level of blood lipids in patients, with high safety and worthy of clinical application.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Simulation Study on Fire Visibility of Typical Floor Planes of Modern Super High-Rise Office Buildings in China

With the development of office forms, the space form of super high-rise office buildings changed from the unitary efficient office space to a complex space that integrated office, communication, and experience, which also diversified the design of typical floors in the office zone.However, from the perspective of fire prevention, the placement of shared space changed the form of the plane in typical floors in the office zone, affecting the smoke spreading of fire and paths of personnel evacuation.Hence, the subject on the planar relationship among high-rise office buildings based on fire prevention analysis, which optimizes space design, is worthy of discussion.After collecting many cases of super high-rise office buildings in china, this study categorized them into six typical planes and adopted the software pyro sim for comparative simulation of the smoke spreading of fire.By comparing the visibility of different zones in fires, this study analyzed the effects of the area of the office zone, the location of the atrium, and the form of the plane on the fire visibility on the typical floor and put forth the key factors that influence fire visibility, thus optimizing the plane design of the typical floor of super high-rise buildings.The findings show that in the six fire scenes, the area of the office zone is between 1136m2 and 1736m2.The peak of duration for visibility decline at 1.5 m appeared in scene 3.Its office zone is 1536m2, and the duration of visibility decline is greater than 1000 s.In other fire scenes, the duration of visibility decline is less than 300 s.By comparing the plane arrangement features of the fire scenes, the paper concludes that in a given fire scene, establishing an atrium in the office zone, expanding the length of the adjacent edge between the atrium and the office zone, and building an evacuation corridor between the atrium and the core tube can greatly extend the effective evacuation time.This can serve as reference for the plane design of super high-rise office buildings.

Journal: Complexity (2020)
Publication types: Research Article;
Research on Lung Nodule Detection Based on Improved Target Detection Network

Lung nodules are an early symptom of lung cancer.The earlier they are found, the more beneficial it is for treatment.However, in practice, chinese doctors are likely to cause misdiagnosis.Therefore, deep learning is introduced, an improved target detection network is used, and public datasets are used to diagnose and identify lung nodules.This paper selects the mask-rcnn network and uses the dense block structure of densenet and the channel shuffle convolution method to improve the mask-rcnn network.The experimental results prove that proposed algorithm is extremely effective.

Journal: Complexity (2020)
Publication types: Research Article;
Clinical Features and Risk Factors of Fever in Acute Gouty Arthritis

S .This study aimed to investigate the clinical characteristics and risk factors of fever in hospitalised patients with acute gouty arthritis (aga).Methods .The clinical data of 167 hospitalised patients with aga who met the inclusion criteria were retrospectively analysed.The demographic, clinical, and medication data of patients with and without fever were compared, and risk factors associated with fever were identified via logistic regression analysis.Results .The incidence of fever in hospitalised patients with aga was 31.1%, with low‐grade fever being predominant.Visual analogue scale (vas) scores, white blood cell counts, neutrophil proportion, c‐reactive protein (crp) levels, and erythrocyte sedimentation rate (esr) were higher in the fever group than in the non‐fever group ( p &lt; 0.05 for all).In addition, the incidence rates of arthritis of single knee and polyarthritis were higher in patients in the fever group ( p &lt; 0.05).The proportion of patients who received betamethasone injection and combination therapy were higher in the fever group ( p &lt; 0.05).However, no significant differences were observed in age; sex; uric acid (ua) levels; and the incidence rate of hypertension, diabetes mellitus, cardiovascular disease, and renal function abnormalities between the two groups.Logistic regression analysis revealed that arthritis of single knee, polyarthritis, age of ≥65 years, crp levels, and vas scores were risk factors for concomitant aga and fever.Among these factors, crp levels and vas scores were identified as independent risk factors (odds ratio [or], 1.014 and 1.686, respectively; 95% confidence interval [ci], 1.004–1.025 and 1.115–2.549, respectively; p &lt; 0.05 for both).Conclusion .The incidence of fever is high in hospitalised patients with aga.Elderly patients, patients with arthritis affecting only one knee, and those with polyarthritis are predisposed to fever.In addition, the risk of developing fever increases with increasing vas scores and crp levels, and patients presenting with fever require enhanced anti‐inflammatory and analgesic therapy.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Predicting the Growth of F. proliferatum and F. culmorum and the Growth of Mycotoxin Using Machine Learning Approach

In distinct parts of the food web, fusarium culmorum and fusarium preserving the relationship can germinate and grow zearalenone (zea) and fumonisins (fum), accordingly.Antimicrobial drugs used to combat these fungi and toxic metabolites raise the risk of hazardous residue in food products, as well as the development of fungus tolerance.For modeling fungal growth and pathogenicity under separate water action ( a q ) (0.96 and 0.99) and surface temp (20 and 28°c) tyrannies, several machine learning (ml) methodologies (artificial neural, regression trees, and extreme rise enhanced trees) and multiple regression model (mlr) were used also especially in comparison.Gr and mycotoxin levels inside the environment often reduced as eoc concentrations grew, although some treatment in association with specific a q and temperature values caused zea production.In terms of predicting the growth rate of f.Culmorum and f.Maintaining the relationship and the production of zea and fum, random forest techniques outperformed neural network models and extreme gradient boosted trees.The mlr option was the most inefficient.It is the first research to look at the ml potential of bio evoh products containing eocs and ambient variables of f.Culmorum and f.Proliferatum development, as well as the generation of zearalenone and fumonisins.The findings show that these entire novel wrapping technologies, in tandem using machine learning techniques, could be useful in predicting and controlling the dangers connected with fungal species or biotoxins in foodstuff.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Research on Microseismic Source Location Method Based on Waveform Characteristics Monitored by Nanomaterial Sensor under the Background of Metal Oxide Polluted Environment

In recent years, the monitoring range of source location technology has developed from being one‐dimensional and two‐dimensional to being three‐dimensional.However, due to the complexity and nonuniformity of the seismic wave propagation medium and the uncertainty of the propagation law, there will be large errors in the source location results.Therefore, the analysis of vibration signal has become the key problem of current research.This paper designs a microseismic monitoring system based on internet of things sensors, which can monitor the vibration wave characteristics of vibration signals.In order to test the positioning accuracy of the system, this paper introduces three positioning methods: target positioning method based on time difference, time delay estimation method based on emd, and source target positioning method based on the characteristic frequency of vibration signal.The purpose of this paper is to find the most accurate method from the three source location methods.Through these three methods, the vibration source generated by a single person walking in situ can be located in the vibration positioning experiment of human walking.The error between the actual position and the measurement source position is compared.The results show that the time delay estimation method based on empirical mode decomposition has the highest positioning accuracy.In addition, in the microseismic experiment, it is proved that the positioning accuracy of emd using l1 norm statistical criterion is higher than that using l2 norm statistical criterion.

Journal: Bioinorganic Chemistry and Applications (2022)
Publication types: Research Article;
A Study on Glycyrrhiza glabra-Fortified Bread: Predicted Glycemic Index and Bioactive Component

Bread is one of the highest‐selling food products throughout the world.Lots of demand arose from the bread producers by the consumers to convert the traditional bread into functional food.In this study, normal bread was converted to functional herbal bread by infusing it with extracts of glycyrrhiza glabra .The functional components of the glycyrrhiza glabra were analyzed by liquid chromatography‐mass spectroscopy (lcms).The antioxidant study revealed that the extract has high antioxidant potency.The present study also investigated the antidiabetic potency of the extract.Bread is fortified with various percentages of glycyrrhiza glabra , such as 2, 4, and 6.The fortified bread was analyzed for various sensory and taste parameters.Biochemical assays such as the in vitro digestibility test and glycaemic index suggest that fortified bread reduces the glycaemic index.From the study, it was inferred that 6% of infused bread was found to have high potency as a functional food when compared to 2 and 4%.From the above study, it was suggested that fortified bread reduces the glycaemic index and is best suited for diabetic people and diet watchers.

Journal: Bioinorganic Chemistry and Applications (2022)
Publication types: Research Article;
Clinical Diagnostic Value of Quantitative Hepatitis B Virus Core Antibody Test in Chronic Viral Hepatitis B

The level of chb virus (hbv) core antibody (hbc ab) is different in four stages of chronic hbv infection and may be used for differential diagnosis of the natural history of chronic hbv infection.To address this question, we examined multiple blood biomarkers and assessed the efficacy to diagnose different stages of chronic hbv infection.The quantitative detection of hbc ab, hepatitis b surface antigen (hbs ag), hbv dna, alanine aminotransferase (alt), aspartate aminotransferase (ast), and platelet count (plt) were determined in the serum of 73 cases of low-replicative phase (lr), 46 cases of immune-tolerant phase (it), 44 cases of immune clearance phase (ic), and 57 cases of hbe ag-negative hepatitis (enh).Differentiating performance of these serum protein levels was analyzed by receiver operating characteristic (roc) curve analysis.Our results showed that the levels of hbc ab, alt, and ast levels were significantly higher in ic and enh than those in lr and it (both p ≤ 0.001 ).The levels of hbv dna and hbs ag were higher in ic and it than those in lr and enh (both p ≤ 0.001 ).Logistic regression models showed that hbc ab, hbs ag, hbv dna, alt, and ast were the independent variables, respectively, and when combined, they provided high diagnostic accuracy for the staging of chb.To sum up, hbc ab quantification is a new index, which can reflect whether the liver is in the immune activation state of hbv infection, and is related to the inflammatory state of the host liver.The combined detection of hbc ab quantification and other indicators has showed promising efficiency for staging of ic and enh and can assist the diagnosis and treatment of chb.

Journal: Bioinorganic Chemistry and Applications (2021)
Publication types: Research Article;
Study on Nano Drug Particles in the Diagnosis and Treatment of Alzheimer’s Disease in the Elderly

To study the clinical effect of nano drug particles in the diagnosis and treatment of alzheimer’s disease in the elderly, we promote the research on the treatment of alzheimer’s disease and provide basis.Methods .80 patients with alzheimer’s disease treated in our hospital from april 2021 to april 2022 were selected as the research objects and were divided into the reference group and the observation group by random number table method.The reference group was given traditional treatment drugs, and the observation group was given nano drug particles.The treatment effect, blood lipid level, cognitive function status, and comprehensive effective rate of the two groups were compared, and the treatment data of the patients were scored by adl and mmse scale to understand the intelligence level and daily living ability of the patients.Results .From the comparison results, it is found that the blood lipid level of the control group was in the normal range.The cognitive function of the control group was also better than that of the reference group.The scores of adl and mmse in the control group were higher than those in the reference group.The effective rate of the control group was also higher than that of the reference group; p &lt; 0.05, with statistical significance.Conclusion .In the diagnosis and treatment of alzheimer’s disease in the elderly, nano drug particles have good stability and less toxic and side effects, improve the ability of daily living of patients, and have good clinical treatment effect, which is worthy of clinical application.

Journal: Bioinorganic Chemistry and Applications (2022)
Publication types: Research Article;
Research on the Purification of Environmental Pollution by Biomaterials and Its Treatment Methods in the Development of Rural Cultural and Creative Industries

Since our country put forward the rural revitalization strategy, we have attached great importance to the construction and development of urban and rural areas.In recent years, we have continuously enhanced the driving force of development and further promoted rural reform.However, in the construction of rural cultural industry, how to purify environmental pollution is a key and difficult point.Through the comprehensive analysis of the role and effect of biomaterials in environmental pollution purification, this study compares the comprehensive role of different materials in environmental purification, compares the trend of environmental pollution in the development of rural industries in recent years, and analyzes the coupling degree of environmental pollution purification in different technological environments.Through the analysis, we can draw a conclusion that under the action of nanomaterials and biomaterials, some water pollution, air pollution, construction waste pollution, and noise pollution in industrial development have achieved good results and impact.Through continuous practice and research, it can be seen that biotechnology and materials can play a relatively good role in the environmental pollution control.And this treatment technology has the advantages of low cost, high efficiency, and no secondary pollution.It also plays an important role in the treatment of pollutants and the development of new energy.It conforms to the concept of sustainable development and environmental construction in the modern society and provides more reference data and research value for the future research and development prospects of nanomaterials and biomaterials in industrial development and environmental governance.

Journal: Bioinorganic Chemistry and Applications (2022)
Publication types: Research Article;