syedzayyan/paper_mill_benchmark huggingface dataset:
A Study of Body Modification Artists' Knowledge, Attitudes, and Practices Toward Infection Control: A Questionnaire-Based Cross-Sectional Study.

Tattoos and piercings, which were once considered taboo, are now widespread like an epidemic, among people of all ages and gender.The rising demand for such body alterations has given rise to a large number of infective complications.This study was, therefore, designed to assess the infection control knowledge, attitudes, and practices of body modification artists in ethiopia, 2021.Methods an anonymous observational cross-sectional study was conducted in addis ababa, ethiopia, from may 25 to june 22, 2021.The data collection instrument was a structured questionnaire that covered the participants' socio-demographic characteristics, knowledge, attitudes, and practices related to infection control.On the whole, 172 tattoo and body piercing artists participated in the study.Spss v.20 software was used for data entry and analysis.Pearson's correlation test,t-test, tukey's test, and multiple linear regression analysis were conducted during the data analysis.Results male participants constituted well over three-fourths (96.5%, n = 166) of the sample considered in the study.According to the result, the participants' knowledge of infection control received the lowest score (7.1 ± 1.22).Participants' scores of knowledge of infection control increased with an increase in their experience in the multiple linear regression.Experience and training time were also associated with knowledge.Infection control practice was positively associated with the respondents' attitudes.After controlling other variables, it was found that a one-unit increase in respondents' attitude scores increased their practice level by 86%.Conclusion this is the first study in ethiopia to examine tattooists' and body piercers' infection control knowledge, attitude, and practice.Minimum standards for infection control in inking and piercing establishments are necessary.It is therefore important that local authorities and public health professionals work towards laying down the minimum code of practice for infection control in inking and piercing establishments.

Journal: Risk management and healthcare policy (2022)
Publication types: Journal Article
Mean platelet volume combined red cell distribution width as biomarker of chronic obstructive pulmonary disease with pulmonary heart disease.

And objective platelet activation, inflammatory reactions and oxidative stress are common pathogenesis of chronic obstructive pulmonary disease (copd) with pulmonary heart disease (phd).Mean platelet volume (mpv) and red blood cell distribution width (rdw) form part of the pathomechanisms of these conditions.Here, we investigated whether mpv and rdw can be biomarkers of phd occurring secondary to copd.Materials and methods this was a retrospective study on 229 participants with copd.Among them, 69 had phd.Complete blood count (cbc), blood gas analysis, pulmonary function tests and echocardiography were analyzed.Results mpv and rdw-standard deviation (rdw-sd) were significantly higher in patients with phd than in patients without phd (p ≤ 0.001).Mpv and rdw-sd were positively correlated with pulmonary artery pressure (pap) and the size of the right ventricle (p ≤ 0.05).Multivariate regression analysis showed that the risk of phd increased 3-fold per unit rise in mpv (or = 2.901, p ≤ 0.001).We observed that the risk of phd increased 1.5 times per unit rise in rdw-sd (or = 1.371, p ≤ 0.001).the auc of roc curve for the combined mpv and rdw-sd in predicting phd among copd patients was 0.900 (95%ci: 0.846-0.954, p ≤ 0.001), with a sensitivity of 76.8% and a specificity of 99.4%.Conclusions both mpv and rdw-sd were significantly elevated and correlated with disease severity in copd patients with phd.A combination of these two parameters presents an effective biomarker of phd.

Journal: The clinical respiratory journal (2020)
Publication types: Journal Article
Triterpenoid saponins from the buds of Lonicera similis.

Four new lupane triterpenoid saponins, along with one known lupane and eight hederagenin saponins, were isolated from the et oh extract of the buds of lonicera similis hemsl.The structures of the new compounds were established as 3-o-β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl 23-hydroxybetulinic acid 28-o-β-d-glucopyranosyl ester (lonisimilioside a, 1), 3-o-β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl 23-hydroxybetulinic acid 28-o-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl ester (lonisimilioside b, 2), 3-o-β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl betulinic acid 28-o-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl ester (lonisimilioside c, 3) and 3-o-β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl betulinic acid 28-o-β-d-glucopyranosyl ester (lonisimilioside d, 4), respectively.The cytotoxic activities of the isolates against human cancer cell lines hep g2, mcf-7 and a-549 were evaluated.Only the monodesmosidic saponin with a free carboxyl group at c-28 (12) exhibited significant cytotoxicities against hep g2, mcf-7 and a-549 cell lines with the ic50values of 8.98 ± 0.19, 12.48 ± 0.45 and 11.62 ± 0.54 μm, respectively.Furthermore, hoechst fluorescence 33342 staining was used to demonstrate that 12 could induce hep g2 and a-549 cells apoptosis significantly.

Journal: Natural product research (2018)
Publication types: Journal Article
Evaluation of biomarkers for treatment selection using individual participant data from multiple clinical trials.

Biomarkers that predict treatment effects may be used to guide treatment decisions, thus improving patient outcomes.A meta-analysis of individual participant data (ipd) is potentially more powerful than a single-study data analysis in evaluating markers for treatment selection.Our study was motivated by the ipd that were collected from 2 randomized controlled trials of hypertension and preeclampsia among pregnant women to evaluate the effect of labor induction over expectant management of the pregnancy in preventing progression to severe maternal disease.The existing literature on statistical methods for biomarker evaluation in ipd meta-analysis have evaluated a marker's performance in terms of its ability to predict risk of disease outcome, which do not directly apply to the treatment selection problem.In this study, we propose a statistical framework for evaluating a marker for treatment selection given ipd from a small number of individual clinical trials.We derive marker-based treatment rules by minimizing the average expected outcome across studies.The application of the proposed methods to the ipd from 2 studies in women with hypertension in pregnancy is presented.

Journal: Statistics in medicine (2018)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
A z-gradient array for simultaneous multi-slice excitation with a single-band RF pulse.

Multi-slice radiofrequency (rf) pulses have higher specific absorption rates, more peak rf power, and longer pulse durations than single-slice rf pulses.Gradient field design techniques using a z-gradient array are investigated for exciting multiple slices with a single-band rf pulse.Theory and methods two different field design methods are formulated to solve for the required current values of the gradient array elements for the given slice locations.The method requirements are specified, optimization problems are formulated for the minimum current norm and an analytical solution is provided.A 9-channel z-gradient coil array driven by independent, custom-designed gradient amplifiers is used to validate the theory.Results performance measures such as normalized slice thickness error, gradient strength per unit norm current, power dissipation, and maximum amplitude of the magnetic field are provided for various slice locations and numbers of slices.Two and 3 slices are excited by a single-band rf pulse in simulations and phantom experiments.Conclusion the possibility of multi-slice excitation with a single-band rf pulse using a z-gradient array is validated in simulations and phantom experiments.Magn reson med 80:400-412, 2018.© 2017 international society for magnetic resonance in medicine.

Journal: Magnetic resonance in medicine (2018)
Publication types: Journal Article
Comparison of intravitreal injection of conbercept and triamcinolone acetonide for macular edema secondary to branch retinal vein occlusion.

To compare the safety and efficacy of the intravitreal injection of conbercept (ivc) and triamcinolone acetonide (ivta) for macular edema (me) secondary to branch retinal vein occlusion (brvo).Methods a prospective, randomized clinical study.Patients with me secondary to brvo were randomly assigned to either ivc group or ivta group at a ratio of 2:1 and a 12-month follow-up was performed.The efficacy outcome measures included the mean changes and differences in best corrected visual acuity (bcva) and the central retinal thickness (crt).The safety profiles and the mean retreatment intervals were also compared.Results there was no statistically significant difference of baseline between the two groups (ivc group,n=36; ivta group,n=17).At 12mo, the bcva letters improved by 27.31±18.36 in the ivc group, and 13.53±11.37 in the ivta group (p=0.0004).Crt reduction was 253.33±163.69 and 150.24±134.32 μm, respectively (p=0.0034).The mean bcva in the ivc group was superior to that of the ivta group for months 6-12 (p<0.01).The mean crt at 9 and 12mo were thinner in the ivc group compared to the ivta group (p<0.01).The mean retreatment interval in the ivc group was longer than that in the ivta group (97.40±36.27dvs68.71±36.38d,p=0.0030).One eye in the ivc group and seven eyes in the ivta group developed elevated intraocular pressure (iop;p=0.0012).The proportion of eyes with cataract new-onset or progression were 19.44% in the ivc group and 64.71% in the ivta group (p=0.0012).Conclusion ivc could maintain or improve bcva and reduce crt for a longer time and have longer retreatment interval than ivta.In addition, patients treated with ivta are more susceptible to iop elevation and cataract progression.

Journal: International journal of ophthalmology (2020)
Publication types: Journal Article
A comparison of the antimicrobial resistance of fecal Bacteroides isolates and assessment of the composition of the intestinal microbiotas of carbapenem-treated and non-treated persons from Belgium and Hungary.

The antimicrobial susceptibilities of bacteroides strains isolated from the feces of imipenem-treated patients from belgium and hungary were compared with those isolated from the normal microbiota from these two and five other european countries and assessed.Of the 10 antibiotics tested, highly significant differences were found with cefoxitin (decrease for belgium and for this two and the five countries from the previous study), clindamycin (decrease for belgium and for this two and the five countries from the previous study) and moxifloxacin (increase for belgium and for this two and the five countries from the previous study) relative to normal microbiota strains reported earlier.Imipenem treatment brought about modest, but notable differences in the compositions of the microbiomes where there was less diversity in the treated group relative to the non-treated group.

Journal: Anaerobe (2022)
Publication types: Journal Article
Anshen Buxin Liuwei Pill, a Mongolian Medicinal Formula, Could Protect H2O2-Induced H9c2 Myocardial Cell Injury by Suppressing Apoptosis, Calcium Channel Activation, and Oxidative Stress.

Anshen buxin liuwei pill (ablp) is a mongolian medicinal formula which has a therapeutic effect on the symptoms such as coronary heart disease, angina pectoris, arrhythmia, depression and irritability, palpitation, and short breath.However, its bioactivity against cardiac injury remains unclear.Methods the protective effect of ablp was evaluated using h9c2 cells.Cell viability, intracellular ca2+, reactive oxidative indices, and mitochondrial membrane potential (∆ψ) were assessed, respectively.The m rna levels of ca2+channel-related genes (dhpr, ry r2, and scn5a) and oxidative stress-related genes (keap1, nrf2, and ho-1) were measured by rt-pcr.Results 0.5-50μg/m l ablp could significantly decrease h2o2-induced cell injury by suppressing cell necrosis/apoptosis and excess oxidative stress, ameliorating the collapse of ∆ψ, and reducing intracellular ca2+concentration.Furthermore, 0.5-50μg/m l ablp reversed h2o2-induced imbalance in the m rna levels of dhpr, ry r2, scn5a, keap1, nrf2, and ho-1 gene in h9c2 cells, which further illustrate the mechanism.Conclusion ablp provided protective and therapeutic benefits against h2o2-induced h9c2 cell injury, indicating that this formula can effectively treat coronary disease.In addition, the present study also provides an in-depth understanding of the pharmacological functions of ablp, which may lead to further successful applications of mongolian medicine.

Journal: Evidence-based complementary and alternative medicine : eCAM (2022)
Publication types: Journal Article
Associations of AHR, CYP1A1, EPHX1, and GSTP1 genetic polymorphisms with small-for-gestational-age infants.

To investigate the influences of aryl hydrocarbon (ahr), cytochrome p450 (cyp1a1), epoxide hydrolase 1 (ephx1), and glutathione s-transferase p1 (gstp1) genetic polymorphisms on small-for-gestational-age (sga) infants.Methods this nested case-control study (126 cases and 381 controls) was based on a prospective cohort study in shanxi province, china.We collected the general information of subjects using questionnaire and identified their single nucleotide polymorphisms by the mass array genotyping platform.Results the polymorphisms of cyp1a1 (rs4646421 and rs4646903) and ephx1 (rs1051740) were significantly associated with sga.Neonates of women with ephx1 (rs1051740) and gstp1 (rs1695) variant alleles were at a significantly increased risk of sga compared with the reference group (or = 5.26; 95% ci, 1.08-25.66), as were neonates of women with cyp1a1 (rs4646903) and ephx1 (rs1051740) variant alleles (or = 7.11; 95% ci, 1.55-32.62).The results of strata analysis by ahr (rs2282883 and rs17137566) showed that the associations between the polymorphisms of cyp1a1 (rs4646421 and rs4646903) ephx1 (rs1051740), gstp1 (rs1695) and sga were of significance in women with variant heterozygous or homozygous genotype.Conclusions cyp1a1 (rs4646421 and rs4646903), ephx1 (rs1051740), and gstp1 (rs1695) genetic variances might increase the risk of sga.Ahr (rs2282883 and rs17137566) resulted in estimated effects varying across strata on cyp1a1 (rs4646421 and rs4646903), ephx1 (rs1051740), and gstp1 (rs1695).

Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2021)
Publication types: Journal Article
Temporal changes in laboratory markers of survivors and non-survivors of adult inpatients with COVID-19.

Coronavirus disease 2019 (covid-19) is caused by severe acute respiratory syndrome coronavirus 2, and outbreaks have occurred worldwide.Laboratory test results are an important basis for clinicians to determine patient condition and formulate treatment plans.Methods fifty-two thousand six hundred forty-four laboratory test results with continuous values of adult inpatients who were diagnosed with covid-19 and hospitalized in the fifth hospital in wuhan between 16 january 2020 and 18 march 2020 were compiled.The first and last test results were compared between survivors and non-survivors with variance test or welch test.Laboratory test variables with significant differences were then included in the temporal change analysis.Results among 94 laboratory test variables in 82 survivors and 25 non-survivors with covid-19, white blood cell count, neutrophil count/percentage, mean platelet volume, platelet distribution width, platelet-large cell percentage, hypersensitive c-reactive protein, procalcitonin, d-dimer, fibrin (ogen) degradation product, middle fluorescent reticulocyte percentage, immature reticulocyte fraction, lactate dehydrogenase were significantly increased (p < 0.05), and lymphocyte count/percentage, monocyte percentage, eosinophil percentage, prothrombin activity, low fluorescent reticulocyte percentage, plasma carbon dioxide, total calcium, prealbumin, total protein, albumin, albumin-globulin ratio, cholinesterase, total cholesterol, nonhigh-density/low-density/small-dense-low-density lipoprotein cholesterol were significantly decreased in non-survivors compared with survivors (p < 0.05), in both first and last tests.Prothrombin time, prothrombin international normalized ratio, nucleated red blood cell count/percentage, high fluorescent reticulocyte percentage, plasma uric acid, plasma urea nitrogen, cystatin c, sodium, phosphorus, magnesium, myoglobin, creatine kinase (isoenzymes), aspartate aminotransferase, alkaline phosphatase, glucose, triglyceride were significantly increased (p < 0.05), and eosinophil count, basophil percentage, platelet count, thrombocytocrit, antithrombin iii, red blood cell count, haemoglobin, haematocrit, total carbon dioxide, acidity-basicity, actual bicarbonate radical, base excess in the extracellular fluid compartment, estimated glomerular filtration rate, high-density lipoprotein cholesterol, apolipoprotein a1/ b were significantly decreased in non-survivors compared with survivors (p < 0.05), only in the last tests.Temporal changes in 26 variables, such as lymphocyte count/percentage, neutrophil count/percentage, and platelet count, were obviously different between survivors and non-survivors.Conclusions by the comprehensive usage of the laboratory markers with different temporal changes, patients with a high risk of covid-19-associated death or progression from mild to severe disease might be identified, allowing for timely targeted treatment.

Journal: BMC infectious diseases (2020)
Publication types: Comparative Study;Journal Article
Relationship between Cervicocephalic Kinesthetic Sensibility Measured during Dynamic Unpredictable Head Movements and Eye Movement Control or Postural Balance in Neck Pain Patients.

Cervical afferent input is believed to affect postural balance and oculomotor control in neck pain patients, but its relationship to cervicocephalic kinesthesia, describing movement sense, has not yet been studied.The aim of this study was to analyze the relationship of two aspects of cervicocephalic kinesthesia to postural balance and oculomotor control in neck torsion positions.Forty-three idiopathic neck pain patients referred from orthopedic outpatient clinics and forty-two asymptomatic controls were enrolled in the study.A force plate was used to measure center-of-pressure movements during parallel stances under neutral and neck torsion maneuvers.Video-oculography was used to assess eye movements during smooth pursuit neck torsion test (spntt), while kinesthetic awareness was measured using the butterfly test and head-to-neutral relocation test.Multiple regression was used to describe relationships between tests.Body sway in the anterior-posterior direction was related to butterfly parameters but less to the head-to-neutral test.A medium relationship between butterfly parameters and gain during spntt, with less spnt-difference, was observed, but not for the head-to-neutral test.It can be concluded that specific aspect of neck kinesthetic functions (i.e., movement sense) importantly contributes towards oculomotor and balance control, which is more evident under neck torsion positions in neck pain patients, but is less pronounced in asymptomatic individuals.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Current Status of Mosquito Handling, Transporting and Releasing in Frame of the Sterile Insect Technique.

The sterile insect technique (sit) and its related technologies are considered to be a powerful weapon for fighting against mosquitoes.As an important part of the area-wide integrated pest management (aw-ipm) programs, sit can help reduce the use of chemical pesticides for mosquito control, and consequently, the occurrence of insecticide resistance.The mosquito sit involves several important steps, including mass rearing, sex separation, irradiation, packing, transportation, release and monitoring.To enable the application of sit against mosquitoes to reduce vector populations, the joint food and agriculture organization of the united nations (fao) and the international atomic energy agency (iaea) centre (previously called division) of nuclear techniques in food and agriculture (hereinafter called joint fao/iaea centre) and its insects pest control sub-program promoted a coordinated research project (crp) entitled "mosquito handling, transport, release and male trapping methods" to enhance the success of sit.This article summarizes the existing explorations that are critical to the handling and transporting of male mosquitoes, offers an overview of detailed steps in sit and discusses new emerging methods for mosquito releases, covering most processes of sit.

Journal: Insects (2022)
Publication types: Journal Article;Review
Effects of patellar taping on knee pain, functional disability, and patellar alignments in patients with patellofemoral pain syndrome: A randomized clinical trial.

Question what are the effects of patellar taping on pain, functional disability and patellar alignments in patellofemoral pain syndrome (pfps)?Design double-blind randomized clinical trial.Participants thirty pfps patients were randomly divided into two groups, intervention and control.Intervention patients in control group received only the routine physiotherapy.In addition to routine physiotherapy, patellar taping was used in the intervention group.Each patient was treated for 12 sessions over a period of 4 weeks.Outcome measures the koos and vas questionnaires were used to assess the quality of life (qol) and pain intensity, respectively.Three components of patellar alignment including patellofemoral congruence angle (pfca), lateral patellofemoral angle (lpfa) and lateral patellar displacement (lpd) were evaluated using the skyline radiography method.Results the results indicated that there was no significant difference between the control and intervention groups for lpd (p = 0.586), pfca (p = 0.704) and lpfa (p = 0.176) variables.No significant difference was found between the two groups in all items of the koos questionnaire.The knee pain intensity was significantly reduced in both the intervention (p < 0.001) and control (p = 0.001) groups at the end of the 4th week.Conclusion the results of the present study indicated that patellar taping compared to routine physiotherapy treatments had no beneficial effects on pain reduction, qol improvement and correction of patellar alignment in psps patients.Trial registration irct201111012851n2.

Journal: Journal of bodywork and movement therapies (2018)
Publication types: Journal Article;Randomized Controlled Trial