syedzayyan/paper_mill_benchmark huggingface dataset:
The alcohol consumption of wine drinkers with the onset of Covid-19.

The onset of covid-19 has been the most evident global crisis of the current decade so far.This study explores the difference between professionals in the drinks industry and non-professional wine lovers and the impact on their consumption behaviour of wine and other alcoholic beverages in the early stages of the pandemic, particularly in the context of anxiety.A survey by questionnaire was administered worldwide from the end of march to the end of june 2020 to test four research hypotheses.Results are relevant for the alcoholic beverage industry and public policy.They highlight a higher incidence of unchanged alcohol consumption among non-professionals.They also reveal similarities and differences in changes in consumption behaviour and trends among the two cohorts.Anxiety has an impact on the wine consumption of professionals, and on beer consumption of non-professionals, where the gender and age of respondents are also relevant.The findings of a short qualitative data-collection process enrich our understanding of the results.

Journal: Food quality and preference (2022)
Publication types: Journal Article
Low Perceived Self-Efficacy Impedes Discriminative Fear Learning.

Perceived self-efficacy refers to a subject's expectation about the outcomes his/her behavior will have in a challenging situation.Low self-efficacy has been implicated in the origins and maintenance of phobic behavior.Correlational studies suggest an association between perceived self-efficacy and learning.The experimental manipulation of perceived self-efficacy offers an interesting approach to examine the impact of self-efficacy beliefs on cognitive and emotional functions.Recently, a positive effect of an experimentally induced increased self-efficacy on associative learning has been demonstrated.Changes in associative learning constitute a central hallmark of pathological fear and anxiety.Such alterations in the acquisition and extinction of conditioned fear may be related to cognitive and neurobiological factors that predict a certain vulnerability to anxiety disorders.The present study builds on previous own work by investigating the effect of an experimentally induced low perceived self-efficacy on fear acquisition, extinction and extinction retrieval in a differential fear conditioning task.Our results suggest that a negative verbal feedback, which leads to a decreased self-efficacy, is associated with changes in the acquisition of conditioned fear.During fear acquisition, the negative verbal feedback group showed decreased discrimination of fear responses between the aversive and safe conditioned stimuli (cs) relative to a group receiving a neutral feedback.The effects of the negative verbal feedback on the acquisition of fear discrimination learning were indexed by an impaired ability to discriminate the probability of receiving a shock during acquisition upon presentation of the aversive (cs+) relative to the safe stimuli (cs-).However, the effects of low self-efficacy on discrimination learning were limited to fear acquisition.No differences between the groups were observed during extinction and extinction retrieval.Furthermore, analysis of other outcome measures, i.e., skin conductance responses and cs valence ratings, revealed no group differences during the different phases of fear conditioning.In conclusion, lower perceived self-efficacy alters cognitive/expectancy components of discrimination during fear learning but not evaluative components and physiological responding.The pattern of findings suggests a selective, detrimental role of low(er) self-efficacy on the subject's ability to learn the association between ambiguous cues and threat/safety.

Journal: Frontiers in psychology (2019)
Publication types: Journal Article
Can Google Searches Predict the Popularity and Harm of Psychoactive Agents?

Predicting the popularity of and harm caused by psychoactive agents is a serious problem that would be difficult to do by a single simple method.However, because of the growing number of drugs it is very important to provide a simple and fast tool for predicting some characteristics of these substances.We were inspired by the google flu trends study on the activity of the influenza virus, which showed that influenza virus activity worldwide can be monitored based on queries entered into the google search engine.Objective our aim was to propose a fast method for ranking the most popular and most harmful drugs based on easily available data gathered from the internet.Methods we used the google search engine to acquire data for the ranking lists.Subsequently, using the resulting list and the frequency of hits for the respective psychoactive drugs combined with the word "harm" or "harmful", we estimated quickly how much harm is associated with each drug.Results we ranked the most popular and harmful psychoactive drugs.As we conducted the research over a period of several months, we noted that the relative popularity indexes tended to change depending on when we obtained them.This suggests that the data may be useful in monitoring changes over time in the use of each of these psychoactive agents.Conclusions our data correlate well with the results from a multicriteria decision analysis of drug harms in the united kingdom.We showed that google search data can be a valuable source of information to assess the popularity of and harm caused by psychoactive agents and may help in monitoring drug use trends.

Journal: Journal of medical Internet research (2016)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Mitochondria-targetable colorimetric and far-red fluorescent sensor for rapid detection of SO2derivatives in food samples and living cells.

Sulfur dioxide (so2) derivatives are intertwined with many physiological and pathological processes in living systems, and excess intake of them are associated with various diseases.Herein, we have rationally constructed a novel colorimetric and far-red fluorescent probe for hso3-based on a rhodamine analogue skeleton bearing a 3-quinolinium carboxaldehyde moiety.The novel probe exhibited a significant far-red fluorescence "turn-on" response to hso3-, along with obvious color change from reddish to purple via the specific 1,4-nucleophilic addition reaction of hso3-with the quinolinium moiety in 3-(4-(2-carboxyphenyl)-7-(diethylamino)chromenylium-2-yl)-1-methylquinolin-1-ium hypochlorite trifluoromethanesulfonate (aqcb).The aqcb had excellent water-solubility, and presented rapid response (<15 s),highsensibility(lod = 49 n m) and selectivity toward hso3-.In addition, the probe was able to detect the content of hso3-in food samples with satisfactory results.Furthermore, the probe possessed good cell membrane and could be successfully applied for imaging hso3-in the mitochondria of living cells.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2022)
Publication types: Journal Article
Increased Asymmetry of Lower Limbs and Leading Joint Angles during Crossing Obstacles in Healthy Male with Cold Exposure.

Lower ambient temperatures impair neuromuscular function and balance.However, whether lower ambient temperatures could alter joint angles and symmetry of lower limbs during crossing obstacles in males still remains unknown.Therefore, we investigated whether there is reduction of ambient temperature (20°c; 15°c; 10°c) on lower limbs joint angles and symmetry when crossing obstacles in males.On three different occasions, eighteen male participants underwent 30 min exposure to three different environmental temperatures (10°c, 15°c, and 20°c), which was followed by the obstacle crossing test at 10%, 20%, and 30% of the participant leg length.In each trial, we assessed joint angles and symmetry of lower limbs when crossing obstacles at 10%, 20%, and 30% of the participants' leg length.The results showed that leading limb maximum joint angles were greater in 10°c than in 15°c and 20°c when leading limb crossed obstacle heights of 20% and 30% leg length (p 0.05).Lower limb asymmetry increased when participants crossed obstacle heights of 20% and 30% leg length at 10°c (p< 0.05).This study concluded that in male participants, cold exposure can increase lower limb asymmetry to increase falling risk when crossing obstacles.Also, the increased leading limb joint angles and constant trailing limb joint angles increase safety during crossing obstacles.

Journal: Applied bionics and biomechanics (2022)
Publication types: Journal Article
Fathers' and mothers' praise and spatial language during play with first graders: Patterns of interaction and relations to math achievement.

Parents provide motivational and cognitive support within the same interaction, yet researchers have investigated these separately.We examined two key aspects of parental support, praise (motivational support) and spatial language (cognitive support), from fathers and mothers during three tasks with their first-grade children (6-7-year-olds;n= 107; 56 girls; 72.0% white, 23.4% black).Parents' praise and spatial language varied by task but not child sex: both parents produced more praise in the etch-a-sketch and block tasks than the card game and produced more spatial language in the etch-a-sketch task than other tasks.We further examined whether praise and spatial language in the two spatial tasks (etch-a-sketch and block construction) were related to children's later math and spatial skills.We found neither additive nor multiplicative effects of parents' praise or spatial language.We also did not see additive or multiplicative effects of fathers' and mothers' support.However, fathers' greater spatial language at first grade was negatively associated with boys' (but not girls') math achievement in third grade, with greater father spatial tokens related to their sons' lower math achievement.This suggests that boys may perceive fathers' support more negatively than girls do or that fathers may offer additional support for boys with lower abilities.Taken together, this study emphasizes the importance of considering contexts in examining parental support.The correlational nature of the study warrants future research to establish causal relations and to enhance our understanding of multifaceted parent-child interactions.(psyc info database record (c) 2022 apa, all rights reserved).

Journal: Developmental psychology (2022)
Publication types: Journal Article
Compressive Fatigue Investigation on High-Strength and Ultra-High-Strength Concrete within the SPP 2020.

The influence of the compressive strength of concrete on fatigue resistance has not been investigated thoroughly and contradictory results can be found in the literature.To date, the focus of concrete fatigue research has been on the determination of the numbers of cycles to failure.Concerning the fatigue behaviour of high-strength concrete (hpc) and, especially, ultra-high-strength concrete (uhpc), which is described by damage indicators such as strain and stiffness development, little knowledge is available, as well as with respect to the underlying damage mechanisms.This lack of knowledge has led to uncertainties concerning the treatment of high-strength and ultra-high-strength concretes in the fatigue design rules.This paper aims to decrease the lack of knowledge concerning the fatigue behaviour of concrete compositions characterised by a very high strength.Within the priority programme spp 2020, one hpc and one uhpc subjected to monotonically increasing and cyclic loading were investigated comparatively in terms of their numbers of cycles to failure, as well as the damage indicators strain and stiffness.The results show that the uhpc reaches a higher stiffness and a higher ultimate strain and strength than the hpc.The fatigue investigations reveal that the uhpc can resist a higher number of cycles to failure than the hpc and the damage indicators show an improved fatigue behaviour of the uhpc compared to the hpc.

Journal: Materials (Basel, Switzerland) (2022)
Publication types: Journal Article
Electronically Reconfigurable Photonic Switches Incorporating Plasmonic Structures and Phase Change Materials.

The ever-increasing demands for data processing and storage will require seamless monolithic co-integration of electronics and photonics.Phase-change materials are uniquely suited to fulfill this function due to their dual electro-optical sensitivity, nonvolatile retention properties, and fast switching dynamics.The extreme size disparity however between cmos electronics and dielectric photonics inhibits the realization of efficient and compact electrically driven photonic switches, logic and routing elements.Here, the authors achieve an important milestone in harmonizing the two domains by demonstrating an electrically reconfigurable, ultra-compact and nonvolatile memory that is optically accessible.The platform relies on localized heat, generated within a plasmonic structure; this uniquely allows for both optical and electrical readout signals to be interlocked with the material state of the pcm while still ensuring that the writing operation is electrically decoupled.Importantly, by miniaturization and effective thermal engineering, the authors achieve unprecedented energy efficiency, opening up a path towards low-energy optoelectronic hardware for neuromorphic and in-memory computing.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2022)
Publication types: Journal Article
Severe colchicine poisoning treated successfully with kidney replacement therapy and plasmapheresis: a case report.

Colchicine is commonly prescribed for treatment of inflammatory conditions but has a narrow therapeutic window and dangerous toxicity profile.Here we describe a case of survival after massive unintentional colchicine overdose treated with plasmapheresis and renal replacement therapy.A 37 year old male with history of pericarditis presented to the emergency department with a chief complaint of nausea, vomiting, and diarrhea after unintentionally ingesting 36 mg of colchicine 17 h prior to arrival.An initial colchicine concentration resulted at 5.1 ng/m l (30 h post-ingestion) and peaked at 12 ng/m l (40 h post-ingestion).He was treated with continuous kidney replacement therapy (ckrt) beginning on his first day of hospitalization and with plasmapheresis on hospital days two through four.The patient's course was complicated by multiorgan failure including coagulopathy, respiratory failure, neuropathy, renal failure, pancytopenia, and heart failure.He was discharged to inpatient rehabilitation on hospital day 24.On clinical follow up four months after discharge the patient was found to have no significant persistent morbidity related to colchicine overdose.

Journal: Toxicology communications (2022)
Publication types: Journal Article
Accuracy of Dental Photography: Professional vs. Smartphone's Camera.

There is a scant literature on the accuracy of dental photographs captured by digital single-lens reflex (dslr) and smartphone cameras.The aim was to compare linear measurements of plaster models photographed with dslr and smartphone's camera with digital models.Thirty maxillary casts were prepared.Vertical and horizontal reference lines were marked on each tooth, with exception to molars.Then, models were scanned with the trios 3 basic intraoral dental scanner (control).Six photographs were captured for each model: one using dslr camera (canon eos 700d) and five with smartphone (i phone x) (distance range 16-32 cm).Teeth heights and widths were measured on scans and photographs.The following conclusions could be drawn: (1) the measurements of teeth by means of dslr and smartphone cameras (at distances of at least 24 cm) and scan did not differ.(2) the measurements of anterior teeth by means of dslr and smartphone cameras (at all distances tested) and scan exhibited no difference.For documentational purposes, the distortion is negligeable, and both camera devices can be applied.Dentists can rely on dslr and smartphone cameras (at distances of at least 24 cm) for smile designs providing comparable and reliable linear measurements.

Journal: BioMed research international (2021)
Publication types: Journal Article
A chromosome-level reference genome for the giant pink sea star, Pisaster brevispinus, a species severely impacted by wasting.

Efforts to protect the ecologically and economically significant california current ecosystem from global change will greatly benefit from data about patterns of local adaptation and population connectivity.To facilitate that work, we present a reference-quality genome for the giant pink sea star, pisaster brevispinus, a species of ecological importance along the pacific west coast of north america that has been heavily impacted by environmental change and disease.We used pacific biosciences hi fi long sequencing reads and dovetail omni-c proximity reads to generate a highly contiguous genome assembly of 550 mb in length.The assembly contains 127 scaffolds with a contig n50 of 4.6 mb and a scaffold n50 of 21.4 mb; the busco completeness score is 98.70%.The p.Brevispinus genome assembly is comparable to the genome of the congener species p.Ochraceus in size and completeness.Both pisaster assemblies are consistent with previously published karyotyping results showing sea star genomes are organized into 22 autosomes.The reference genome for p.Brevispinus is an important first step toward the goal of producing a comprehensive, population genomics view of ecological and evolutionary processes along the california coast.This resource will help scientists, managers, and policy makers in their task of understanding and protecting critical coastal regions from the impacts of global change.

Journal: The Journal of heredity (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Prognostic Value of Preoperative Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 Levels for Adjuvant Chemotherapy in Stage II Colorectal Cancer: A Nationwide Multicenter Retrospective Study.

S adjuvant chemotherapy for stage ii colorectal cancer patients with high-risk factors for recurrence can be useful; however, its advantage in prognosis remains to be controversial.Thus, in this study, we aimed to assess whether a combination of preoperative serum carcinoembryonic antigen (cea) and carbohydrate antigen 19-9 (ca19-9) levels can predict the prognosis and advantage of adjuvant chemotherapy.Methods using a japanese nationwide database, in total, 3,688 patients with curative resected stage ii colorectal cancer were registered retrospectively between 2008 and 2012 in 24 referral institutions.Patients were classified into three groups as follows: group a (both non-high levels of cea and ca19-9), group b (either high levels of cea or ca19-9), and group c (both high levels of cea and ca19-9).Results multivariable cox regression analysis, adjusting the depth of tumor invasion, number of dissected lymph nodes, tumor differentiation, lymphatic and venous invasion, and other covariates, showed that the 5-year disease-free survival and overall survival were shorter in group c than in groups a and b.Furthermore, in group c, the 5-year disease-free survival rate was improved in the surgery-plus-ac group compared to the surgery-alone group.Conclusions as with existing high-risk factors for recurrence, the combination assessment of preoperative serum cea and ca19-9 can predict the prognosis for colorectal cancer.Adjuvant chemotherapy may provide a prolonged disease-free survival advantage in stage ii colorectal cancer patients with high levels of both tumor markers.

Journal: Journal of the anus, rectum and colon (2022)
Publication types: Journal Article
Transcriptome-Wide Detection of Intron/Exon Definition in the Endogenous Pre-mRNA Transcripts of Mammalian Cells and Its Regulation by Depolarization.

Pairing of splice sites across an intron or exon is the central point of intron or exon definition in pre-m rna splicing with the latter mode proposed for most mammalian exons.However, transcriptome-wide pairing within endogenous transcripts has not been examined for the prevalence of each mode in mammalian cells.Here we report such pairings in rat gh3 pituitary cells by measuring the relative abundance of nuclear rna-seq reads at the intron start or end (rise).Interestingly, rise indexes are positively correlated between 5' and 3' splice sites specifically across introns or exons but inversely correlated with the usage of adjacent exons.Moreover, the ratios between the paired indexes were globally modulated by depolarization, which was disruptible by 5-aza-cytidine.The nucleotide matrices of the rise-positive splice sites deviate significantly from the rat consensus, and short introns or exons are enriched with the cross-intron or -exon rise pairs, respectively.Functionally, the rise-positive genes cluster for basic cellular processes including rna binding/splicing, or more specifically, hormone production if regulated by depolarization.Together, the rise analysis identified the transcriptome-wide regulation of either intron or exon definition between weak splice sites of short introns/exons in mammalian cells.The analysis also provides a way to further track the splicing intermediates and intron/exon definition during the dynamic regulation of alternative splicing by extracellular factors.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article
Guardiola, Klopp, and Pochettino: The Purveyors of What? The Use of Passing Network Analysis to Identify and Compare Coaching Styles in Professional Football.

We applied social networks analysis to objectively discriminate and describe interpersonal interaction dynamics of players across different top-coaching styles.The aim was to compare metrics in the passing networks of jürgen klopp, pep guardiola, and mauricio pochettino across the uefa champions league seasons from 2017 to 2020.Data on completed passes from 92 games were gathered and average passing networks metrics were computed.We were not only able to find the foundations on which these elite coaches build the passing dynamics in their respective teams, but also to determine important differences that represent their particular coaching signatures.The local cluster coefficient was the only metric not significantly different between coaches.Still, we found higher average shortest-path length for guardiola's network (mean ± std = 3.00 ± 0.45 a.u.) compared to klopp's (2.80 ± 0.52 a.u.,p= 0.04) and pochettino's (2.70 ± 0.39 a.u.,p= 0.01).Density was higher for guardiola's (64.16 ± 20.27 a.u.) than for pochettino's team (51.42 ± 17.28 a.u.,p= 0.008).The largest eigenvalue for guardiola's team (65.95 ± 16.79 a.u.) was higher than for klopp's (47.06 ± 17.25 a.u.,p< 0.001) and pochettino's (42,62 ± 12.01 a.u.,p< 0.001).Centrality dispersion was also higher for guardiola (0.14 ± 0.02 a.u.) when compared to klopp (0.12 ± 0.03 a.u.,p= 0.008).The local cluster coefficient seems to build the foundation for passing work, however, cohesion characteristics among players in the three teams of the top coaches seems to characterize their own footprint regarding passing dynamics.Guardiola stands out by the high number of passes and the enhanced connection of the most important players in the network.Klopp and pochettino showed important similarities, which are associated to preferences toward more flexibility of interpersonal linkages synergies.

Journal: Frontiers in sports and active living (2021)
Publication types: Journal Article