syedzayyan/paper_mill_benchmark huggingface dataset:
Enthusiasm, Questions about ARPA-H.

The biden administration recently proposed creating the advanced research projects agency for health, a biomedical research agency under the nih to accelerate research for widespread diseases such as diabetes, alzheimer disease, and cancer.Although many researchers express enthusiasm for the idea, questions remain about how the entity would function and mesh with existing institutes and agencies.

Journal: Cancer discovery (2021)
Publication types: News
Oleuropein-Rich Olive Leaf Extract Attenuates Neuroinflammation in the Alzheimer's Disease Mouse Model.

Alzheimer's disease (ad) is the most common form of dementia among several neurodegenerative disorders afflicting the elderly.Ad is characterized by the deposition of extracellular amyloid-β (aβ) plaques, disrupted blood-brain barrier (bbb), and neuroinflammation.Several studies have demonstrated the health benefits of olive oil and olive leaf extract (ole) due to their polyphenolic content.The main phenolic compound in ole is glycosylated oleuropein (olg), while the aglycon form of oleuropein (ola) exists in much lower amounts.This work aimed to evaluate the effect of a low dose of olg-rich ole and the mechanism(s) that contributed to the observed beneficial effects against aβ pathology in the homozygous 5x fad mouse model.Mice were fed with ole-enriched diet (695 μg/kg body weight/day) for 3 months, starting at 3 months old.Overall findings demonstrated that ole reduced neuroinflammation by inhibiting the nf-κb pathway and suppressing the activation of nlrp3 inflammasomes and rage/hmgb1 pathways.In addition, ole reduced total aβ brain levels due to increased clearance and reduced production of aβ and enhanced bbb integrity and function, which collectively improved the memory function.Thus, the consumption of ole as a dietary supplement is expected to stop and/or slow the progression of ad.

Journal: ACS chemical neuroscience (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Small fiber neuropathy as a complication of SARS-CoV-2 vaccinations.

Generally, severe acute respiratory syndrome coronavirus 2 (sars-co v-2) vaccinations are not free of side effects.A rarely reported adverse reaction to sars-co v-2 vaccinations is small fiber neuropathy (sfn).Here, we present three patients with sfn after the second dose of messenger ribonucleic acid-based sars-co v-2 vaccines.Data for this study were collected via the self-made platform "pubbly" for reporting side effects of sars-co v-2 vaccinations.Three patients with post-sars-co v-2 vaccination sfn were identified: a 40 yo caucasian female (patient 1), a 52 yo caucasian female (patient 2), and a 32 yo caucasian female (patient 3).Patient 1 complained about fatigue, dizziness, flushing, palpitations, diarrhea, muscle weakness, and gait disturbance 10 days after the second pfizer jab.Patient 2 reported dizziness, balance problems, brain fog, palpitations, dysphagia, and sleep problems.Patient 3 complained about profound fatigue, brain fog, vertigo, pre-syncopal sensations, hair loss, chest pain, dyspnea, palpitations, paresthesias, irregular menstrual cycles, muscle weakness, and hives 1 day after the second moderna dose.All three patients underwent skin biopsy upon which sfn was diagnosed.Patient 1 profited from immunoglobulins, but patient 2 did not require any treatment.Symptoms in patient 3 resolved upon symptomatic treatment.Despite treatment, patient 1 did not completely recover.Sfn can be a rare side effect of sars-co v-2 vaccinations.Post-sars-co v-2 vaccination sfn can be mild or severe and may or may not require treatment.Post-sars-co v-2 vaccination sfn is most likely immune-mediated as it responds to intravenous immunoglobulins.

Journal: Journal of family medicine and primary care (2022)
Publication types: Case Reports;Journal Article
Identifying Candidate Genes for Short Gestation Length Trait in Chinese Qingping Pigs by Whole-Genome Resequencing and RNA Sequencing.

Gestation length is a complex polygenic trait that affects pig fetal development.The qingping (qp) pig, a chinese native black pig breed, is characterized by short gestation length.However, the genetic architecture of short gestation length is still not clear.The present study aimed to explore the genetic architecture of short gestation length in qp pigs.In this study, selective sweep analyses were performed to detect selective sweep signatures for short gestation length traits between 100 qp pigs and 219 pigs from 15 other breeds.In addition, differentially expressed genes for the short gestation length between qp pigs and large white pigs were detected by rna sequencing.Comparing candidate genes from these methods with known genes for preterm birth in the database, we obtained 111 candidate genes that were known preterm birth genes.Prioritizing other candidate genes, 839 novel prioritized candidate genes were found to have significant functional similarity to preterm birth genes.In particular, we highlighted egfr, which was the most prioritized novel candidate relative to preterm birth genes.Experimental validations in placental and porcine trophectoderm cells suggest that egfris highly expressed in the qp pigs with short gestation length and could regulate the nf-κβ pathway and downstream expression of ptgs2.These findings comprehensively identified candidate genes for short gestation length trait at the genomic and transcriptomic levels.These candidate genes provide an important new resource for further investigation and genetic improvement of gestation length.

Journal: Frontiers in genetics (2022)
Publication types: Journal Article
Limb Salvage after Lower-Leg Fracture and Popliteal Artery Transection-The Role of Vessel-First Strategy and Bone Fixation Using the Ilizarov External Fixator Device: A Case Report.

Open traumatic lesion of the popliteal artery is relatively rare.Ischemia time longer than 6 h and severity of limb ischemia have been shown to be associated with an increased risk of limb loss.Severe local infection is critical in the presence of major soft tissue trauma or open fractures.We report the case of a young female who suffered a traumatic transection of the popliteal artery associated with an open fracture of the distal tibia and fibula managed by direct vessel reconstruction with an end-to-end repair and skeletal stabilization initially with half-pin external fixation, then replaced by an ilizarov circular frame.The patient had a very satisfactory outcome, but the fracture healed malunited, later corrected by open reduction and internal fixation with lag-screwing and a neutralization plate.

Journal: Medicina (Kaunas, Lithuania) (2021)
Publication types: Case Reports;Journal Article
Neuromonitoring in Severe Traumatic Brain Injury: A Bibliometric Analysis.

Traumatic brain injury (tbi) is the leading cause of mortality and disability among trauma-related injuries.Neuromonitoring plays an essential role in the management and prognosis of patients with severe tbi.Our bibliometric study aimed to identify the knowledge base, define the research front, and outline the social networks on neuromonitoring in severe tbi.We conducted an electronic search for articles related to neuromonitoring in severe tbi in scopus.A descriptive analysis retrieved evidence on the most productive authors and countries, the most cited articles, the most frequently publishing journals, and the most common author's keywords.Through a three-step network extraction process, we performed a collaboration analysis among universities and countries, a cocitation analysis, and a word cooccurrence analysis.A total of 1884 records formed the basis of our bibliometric study.We recorded an increasing scientific interest in the use of neuromonitoring in severe tbi.Czosnyka, hutchinson, menon, smielewski, and stocchetti were the most productive authors.The most cited document was a review study by maas et al.There was an extensive collaboration among universities.The most common keywords were "intracranial pressure," with an increasing interest in magnetic resonance imaging and cerebral perfusion pressure monitoring.Neuromonitoring constitutes an area of active research.The present findings indicate that intracranial pressure monitoring plays a pivotal role in the management of severe tbi.Scientific interest shifts to magnetic resonance imaging and individualized patient care on the basis of optimal cerebral perfusion pressure.

Journal: Neurocritical care (2022)
Publication types: Journal Article;Review
Swimming Exercise Alleviates Endothelial Mitochondrial Fragmentation via Inhibiting Dynamin-Related Protein-1 to Improve Vascular Function in Hypertension.

Regular exercise has been recommended clinically for all individuals to protect against hypertension but the underlying mechanisms are not fully elucidated.We recently found a significant mitochondrial fragmentation in the vascular endothelium of hypertensive human subjects.In this study, we investigated whether exercise could restore endothelial mitochondrial dynamics and thus improve vascular function in hypertension.Methods vascular endothelial mitochondrial morphological alterations were examined in patients with hypertension and hypertensive animal models.Furthermore, swimming exercise-induced endothelial mitochondrial dynamics and vascular function changes were investigated in spontaneously hypertensive rats (shrs).Results mitochondrial fragmentation with an elevated mitochondrial fission mediator drp1 (dynamin-related protein-1) was observed in the mesenteric artery endothelium from hypertensive patients.A similar mitochondrial fragmentation with increased drp1 expression were exhibited in the aortic endothelium of angiotensin ii-induced hypertensive mice and shrs.Interestingly, swimming exercise significantly reduced vascular drp1 expression and alleviated endothelial mitochondrial fragmentation, thus improving blood pressure in shrs.In cultured endothelial cells, angiotensin ii exposure induced drp1 upregulation, mitochondrial fragmentation and dysfunction, and reduced nitric oxide production, which was blunted by drp1 genetic reduction or its inhibitor mdivi-1.Mdivi-1 administration also ameliorated endothelial mitochondrial fragmentation, vascular dysfunction and blood pressure elevation in shrs while swimming exercise plus mdivi-1 treatment provided no additional benefits, suggesting that drp1 inhibition may partially contribute to swimming exercise-conferred anti-hypertensive effects.Conclusions these findings suggest that swimming exercise alleviates endothelial mitochondrial fragmentation via inhibiting drp1, which may contribute to exercise-induced improvement of vascular function and blood pressure in hypertension.

Journal: Hypertension (Dallas, Tex. : 1979) (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Thyroid gland invasion in total laryngectomy: A systematic review and meta-analysis.

Although guidelines indicate that thyroidectomy should be performed routinely during total laryngectomy in patients with advanced laryngeal cancer, its clinical indications remain controversial.Some researchers believe that thyroid invasion is uncommon and that thyroid preservation should be considered in most cases.Objective this study aimed to identify the incidence and predictors of thyroid invasion in patients with laryngeal cancer to facilitate decision-making regarding whether to perform thyroidectomy during total laryngectomy.Materials and methods the author conducted a systematic review and meta-analysis of all published articles retrieved from a search of the medline (1982-2020) and embase (1971-2020) databases.The published studies of advanced laryngeal cancer with total laryngectomy and partial or total thyroidectomy for laryngeal cancer were selected.The incidence and predictors of thyroid invasion were analyzed.Results we analyzed 25 studies (2177 cases), of which 176 people (8.08%) had thyroid invasion.Subglottic tumors (odds ratio [or], 3.74; 95% ci, 1.75-7.99), t4 stage tumors (or, 2.39; 95% ci, 1.20-4.75), subglottic extension (or, 3.85; 95% ci,2.09-7.11), and thyroid cartilage invasion (or, 3.98; 95% ci, 1.47-10.75) are risk factors for thyroid invasion, and no statistically significant difference was noted between recurrent tumor and thyroid invasion.Conclusion the risk of thyroid invasion was significantly higher when advanced laryngeal cancer involved subglottic tumors, t4 stage tumors, subglottic extension, and thyroid cartilage invasion.The overall incidence of thyroid gland invasion was low; therefore, thyroidectomy may be performed for cases deemed risky rather than as a routine measure of total laryngectomy.Research registry uin: reviewregistry1226.

Journal: International journal of surgery (London, England) (2022)
Publication types: Journal Article;Meta-Analysis;Review;Systematic Review
Practice, barriers, and facilitators of healthcare providers in smoking cessation in Mexico.

To assess the clinical practice, barriers, and facilitators in promoting smoking cessation in primary healthcare clinics in mexico city.Materials and methods a mixed method design was used.Surveys (n = 70) and semi-structured interviews (n = 9) were conducted with health personnel involved in smoking cessation clinics.Results quantitative data revealed that physicians were more likely than nurses to 1) ask patients if they smoke (57.9% vs 34.5%, p = .057), 2) ask patients if they are interested in quitting smoking (65.7% vs 26.9%, p = .003), 3) provide advice to quit smoking (54.3% vs 29.2%, p = .056), and 4) assess whether pharmacotherapy is needed (21.9% vs 10%, p = .285).Qualitative data showed that nurses were more likely than physicians to report lack of resources to refer patients to smoking cessation services, lack of pharmacotherapy availability, and lack of provider training in smoking cessation.Reported barriers include lack of motivation among patients, lack of time for assessment, long appointment wait times, and lack of training.Reported facilitators include existence of smoking cessation programmes and pharmacotherapy at no cost to the patient, and having a multidisciplinary team.Conclusions due to numerous barriers, smoking cessation interventions are partially implemented in primary care clinics in mexico city.A restructuring of services is necessary, and nurses should be given a more prominent role.

Journal: Enfermeria clinica (English Edition) (2022)
Publication types: Journal Article
Novel Approaches Guiding the Future of Spinal Biologics for Bone Regeneration.

Of review despite the continued growth of spine fusion procedures, the ideal material for bone regeneration remains unclear.Current bone graft substitutes and extenders in use such as exogenous bmp-2 or demineralized bone matrix and hydroxyapatite either have serious complications associated with use or lead to clinically significant rates of non-union.The introduction of nanotechnology and 3d printing to regenerative medicine facilitates the development of safer and more efficacious bone regenerative scaffolds that present solutions to these problems.Many researchers in orthopedics recognize the importance of lowering the dose of recombinant growth factors like bmp-2 to avoid the complications associated with its normal required supraphysiologic dosing to achieve high rates of fusion in spine surgery.Recent findings recent iterations of bioactive scaffolds have moved towards peptide amphiphiles that bind endogenous osteoinductive growth factor sources at the site of implantation.These molecules have been shown to provide a highly fluid, natural mimetic of natural extracellular matrix to achieve 100% fusion rates at 10-100 times lower doses of bmp-2 relative to controls in pre-clinical animal posterolateral fusion models.Alternative approaches to bone regeneration include the combination of existing natural growth factor sources like human bone combined with bioactive, biocompatible components like hydroxyapatite using 3d-printing technologies.Their elastomeric, 3d-printed scaffolds demonstrate an optimal safety profile and high rates of fusion (~92%) in the rat posterolateral fusion model.Bioactive peptide amphiphiles and developments in 3d printing offer the promising future of a recombinant growth factor- free bone graft substitute with similar efficacy but improved safety profiles compared to existing bone graft substitutes.

Journal: Current reviews in musculoskeletal medicine (2022)
Publication types: Journal Article;Review
Changes in the Serum Metabolome of Patients Treated With Broad-Spectrum Antibiotics.

The gut microbiome (gmb) generates numerous small chemicals that can be absorbed by the host and variously biotransformed, incorporated, or excreted.The resulting metabolome can provide information about the state of the gmb, of the host, and of their relationship.Exploiting this information in the service of biomarker development is contingent on knowing the gmb-sensitivity of the individual chemicals comprising the metabolome.In this regard, human studies have lagged far behind animal studies.Accordingly, we tested the hypothesis that serum levels of chemicals unequivocally demonstrated to be gmb-sensitive in rodent models would also be affected in a clinical patient sample treated with broad spectrum antibiotics.Methods we collected serum samples from 20 hospitalized patients before, during, and after treatment with broad-spectrum antibiotics.We also collected samples from 5 control patients admitted to the hospital but not prescribed antibiotics.We submitted the samples for a non-targeted metabolomic analysis and then focused on chemicals known to be affected both by germ-free status and by antibiotic treatment in the mouse and/or rat.Results putative identification was obtained for 499 chemicals in human serum.An aggregate analysis did not show any time x treatment interactions.However, our literature search identified 10 serum chemicals affected both by germ-free status and antibiotic treatment in the mouse or rat.Six of those chemicals were measured in our patient samples and additionally met criteria for inclusion in a focused analysis.Serum levels of 5 chemicals (p-cresol sulfate, phenol sulfate, hippurate, indole propionate, and indoxyl sulfate) declined significantly in our group of antibiotic-treated patients but did not change in our patient control group.Conclusions broad-spectrum antibiotic treatment in patients lowered serum levels of selected chemicals previously demonstrated to be gmb-sensitive in rodent models.Interestingly, all those chemicals are known to be uremic solutes that can be derived from aromatic amino acids (l-phenylalanine, l-tyrosine, or l-tryptophan) by anaerobic bacteria, particularly clostridialspecies.We conclude that judiciously selected serum chemicals can reliably detect antibiotic-induced suppression of the gmb in man and thus facilitate further metabolome-based biomarker development.

Journal: Pathogens & immunity (2020)
Publication types: Journal Article
An Improved Analytical Method for the Determination of Brown FK in Food using HPLC.

In this study, an improved analytical method for the detection of the colorant brown fk in foods using high-performance liquid chromatography was developed.The method, which employed an rc-c18 column and diode array detection at 254 nm with sodium acetate solution and methanol as mobile phases, exhibited good linearity (r2 = 1.0), and its limits of detection and quantification were determined to be 0.06 and 0.19 μg/m l, respectively.The precision was found to be 0-1.2% and the accuracy was between 86.5% and 94.8%.Liquid chromatography-tandem mass spectrometry was also performed to identify brown fk in peaks.The pretreatment method was optimized for three different food sample groups, i.e., seafood, noodles and other, affording recoveries of 86.5-92.8%, 90.8-94.8% and 90.0-92.3%, respectively.In addition, inter-laboratory testing was also conducted to check the precision.

Journal: Journal of chromatographic science (2018)
Publication types: Journal Article
Resilience and mental health among juveniles: role of strategies for coping with stress.

Mental health is an important aspect of the process of individual adaptation and development.The present study analysed the role played by resilience in mental health while taking into account both positive and negative indicators among juveniles.The aim of the first study (study 1) is to analyse the relationship between resilience and the broadly understood mental health of juveniles admitted to youth education centres.Study 2 aimed to understand the direct and indirect role of resilience in shaping the mental health of juveniles.In the model we tested, we looked at the relationship among resilience, coping strategies, and mental well-being.Methods the first study involved 201 juveniles, and the second involved 253 juveniles.Resilience was measured by the resilience scale-14.Coping strategies were measured with the brief-cope questionnaire, and information on mental health was obtained using the kutcher adolescent depression scale, the satisfaction with life scale and the warwick-edinburgh mental well-being scale.Results the results of both studies have shown that resilience is an important predictor of the mental health of juveniles, primarily with respect to its positive indicator.The stronger the severity of resilience, the greater the satisfaction with life and mental well-being of the juveniles surveyed.In addition, two coping strategies (seeking support from others and coping through emotions) mediated the relationship between resilience and mental well-being.Conclusions the results obtained indicate that work at the level of juvenile resilience leads to the strengthening of positive mental health indicators and buffering of negative indicators.

Journal: Health and quality of life outcomes (2021)
Publication types: Journal Article
Joint selection of brain network nodes and edges for MCI identification.

And objective functional brain graph (fbg), by describing the interactions between different brain regions, provides an effective representation of f mri data for identifying mild cognitive impairment (mci), an early stage of alzheimer's disease (ad).Prior to the identification task, selecting features from the estimated fbg is a necessary step for reducing computational cost, alleviating the risk of overfitting, and finding potential biomarkers of brain diseases.In practice, either node-based features (e.g., local clustering coefficients) or edge-based features (e.g., adjacency weights) are generally considered in current studies.Despite their popularity, these schemes can only capture one granularity (node or edge) of information in the fbg, which might be insufficient for the classification task and the interpretation of the classification result.Methods to address this issue, in this paper, we propose to jointly select nodes and edges from the estimated fbgs.Specifically, we first assign the edges to different node groups.Then, sparse group least absolute shrinkage and selection operator (sg lasso) is used to select groups (nodes) and edges in the groups towards a better classification performance.Such a technique enables us to simultaneously locate discriminative brain regions, as well as connections between these brain regions, making the classification results more interpretable.Results experimental results show that the proposed method achieves better classification performance than state-of-the-art methods.Moreover, by exploring brain network "features" that contributed most to mci identification, we discover potential biomarkers for mci diagnosis.Conclusion a novel method for jointly selecting nodes and edges from the estimated functional brain graphs (fbgs) is proposed.

Journal: Computer methods and programs in biomedicine (2022)
Publication types: Journal Article