syedzayyan/paper_mill_benchmark huggingface dataset:
Effects of Transcranial Magnetic Stimulation Combined with Computer-Aided Cognitive Training on Cognitive Function of Children with Cerebral Palsy and Dysgnosia

This study is aimed at researching transcranial magnetic stimulation (tms) effects combined with computer-aided cognitive training (cact) on cognitive function of children suffering from cerebral palsy and dysgnosia.Methods.From december 2019 to october 2021, 86 children with cerebral palsy and dysgnosia who were treated at our hospital were recruited and assigned into observation and control groups ( n = 43 , each) using the random number table technique.The observation group received tms combined with cact (tms+cact), whereas the control group received only tms.Chinese wechsler young children scale of intelligence (c-wycsi) and chinese-wechsler intelligence scale for children (c-wisc) were used to evaluate the intelligence level of the two groups; gross motor function measure-88 (gmfm-88) of fudan chinese version was employed for evaluating the gross motor function of the two groups; a comparison was drawn among the two groups for the cerebral hemodynamic parameters before and after the treatment.Results.For young children, the verbal intelligence quotient (viq) scores at 6 and 12 weeks of treatment in the observation group were increased when compared to those in the control group ( 48.91 ± 3.70 vs.47.32 ± 3.33 , 54.25 ± 4.46 vs.49.48 ± 3.36 ), and the observation group’s performance intelligence quotient (piq) score at 12 weeks of treatment was higher as to that of the control group ( 65.38 ± 4.23 vs.62.81 ± 4.74 , all p &lt; 0.05 ).For older age children, the observation group’s viq and piq scores were greater than the control group’s at 6 and 12 weeks of treatment, with statistical significance ( 63.80 ± 3.76 vs.59.50 ± 5.32 , 74.64 ± 12.04 vs.65.08 ± 6.30 ; 63.91 ± 5.96 vs.58.42 ± 3.70 , 72.73 ± 5.06 vs.66.42 ± 5.93 ; all p &lt; 0.05 ).The gmfm-88 scale scores in both groups were increased after 6 and 12 weeks of treatment.After treatment for 12 weeks, the observation group’s a-e scores were greater than those of the control group (all p &lt; 0.05 ).The peak systolic velocity ( v s ), end-diastolic velocity ( v d ), and mean velocity ( v m ) at the anterior cerebral artery (aca), middle cerebral artery (mca), and posterior cerebral artery (pca) in the observation group were dramatically increased than those in the control group (all p &lt; 0.05 ) after 12 weeks of treatment.Conclusion.Tms+cact can effectively improve the intelligence level, cognitive ability, gross motor function, and cerebral blood flow of children suffering from cerebral palsy and intellectual disability.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Effects of Thoracic Paravertebral Block on Postoperative Anxiety and Depression for Patients Undergoing Thoracoscopic Lung Cancer Radical Surgery

This study is aimed at investigating the effect of thoracic paravertebral block (tpvb) on the occurrence of chronic postoperative pain, postoperative anxiety, and depression in patients undergoing thoracoscopic radical lung cancer surgery.A total of 120 patients who underwent thoracoscopic radical lung cancer surgery in our hospital from june 2019 to march 2021 were included.There were 62 males and 58 females, with an age of 18-75 years old and a body mass index of 20-28 kg/m2.Patients were divided into two groups using the random number table method, tpvb group ( n = 60 ) and normal saline group (control group, n = 60 ).Two-point nerve block was performed at t5-6 and t6-7 levels.Patients in the tpvb group received nerve block with 15 m l of 0.375% ropivacaine hydrochloride, while those in the control group received 5 m l of 0.9% normal saline.The numeric rating scale (nrs) scores at rest and during movement at 24 and 48 hours after surgery and the number of times the button on the patient-controlled analgesia pressed at 24 h after surgery in two groups were recorded.All patients were followed up by outpatient visits or phone visits at 1 year after surgery and assessed using leeds assessment of neuropathic symptoms and signs (lanss) pain scale and hospital anxiety and depression scale (hads).According to the inclusion, exclusion, and drop-out criteria, 108 patients were finally included, with 52 patients in the tpvb group and 56 patients in the control group.There was no statistically significant difference between the two groups in terms of age, sex, height, body weight, body mass index, asa classification, and operation time ( p &gt; 0.05 ).Nrs pain scores at 24 h ( p = 0.01 08) and 48 h ( p = 0.0000 ) after surgery, the number of times pressing patient-controlled analgesia at 24 h after surgery ( p = 0.0000 ), the lanss scores ( p = 0.0000 ), hads anxiety score ( p = 0.0000 ), and depression scores ( p = 0.0000 ) at 1 year after surgery in the tpvb group were both significantly lower than those in the control group.To sum up, ultrasound-guided tpvb can effectively relieve pain at 48 hours after thoracoscopic lung cancer radical surgery and chronic postoperative pain at 6 months after v thoracoscopic lung cancer radical surgery.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Effects of the Wenyang Zhenshuai Granule on the Expression of LncRNA-MiR143HG/miR-143 Regulating ERK5 in H9C2 Cardiomyocytes

Chronic heart failure (chf) is a complex clinical syndrome caused by a variety of heart problems, with a high incidence.The 5-year survival rate of patients with clinical symptoms is similar to that of malignant tumors.Wenyang zhenshuai granules are a safe and effective granule of traditional chinese medicine components, including aconite, dried ginger, licorice, and red ginseng.In contemporary clinical applications, it is widely used in acute and chronic heart insufficiency, coronary heart disease, and arrhythmia.This research cultured h9c2 cardiomyocytes and divided them into the normal control group, lnc rna-mi r143hg overexpression group, lnc rna-mi r143hg silence group, adriamycin (adr) group, adr + medicated serum group, adr + lnc rna-mi r143hg overexpression + medicated serogroup, and adr + lnc rna-mi r143hg silence + medicated serogroup.The cells of each group were treated differently, and the survival rate of each group of cells and the expression levels of lnc rna-mi r143hg/mi r-143 and erk5 were detected at the end of the experiment, and the expression of lnc rna-mi r143hg/mi r-143 in h9c2 cardiomyocytes was regulated by wenyang zhenshuai granules’ impact.The results of this study showed that, in the doxorubicin-induced h9c2 cardiomyocyte injury model, the expression of mi r-143 was upregulated, and the expression of lnc rna-mi r143hg and erk5 was significantly downregulated.Wenyang zhenshuai granules can downregulate the expression of mi r-143 to promote erk5 protein expression and phosphorylation.The process is regulated by lnc rna-mi r143hg/mi r-143, which may be one of its important mechanisms for the treatment of chronic heart failure.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Research Article;
Effects of the Dectin-2/TNF-α Pathway on Ventricular Arrhythmia after Acute Myocardial Infarction in Mice

Inflammatory responses are involved in ischemic injuries and cardiac repair after acute myocardial infarction (ami).Dectin-2 is a c-type lectin receptor that induces cytokine production and promotes local inflammatory responses.Methods.Sixty c57bl/6 mice were randomly assigned to a sham-surgery group, ami group, or ami + etanercept group, with 20 mice in each group.Programmed electrical stimulation (pes) was used to anesthetized mice to induce ventricular tachycardia.Real-time polymerase chain reaction (pcr) and western blot analysis were adopted to determine the expression and distribution of dectin-2 in heart tissues.The tumor necrosis factor-α (tnf-α), interferon-gamma (ifn)-γ, interleukin (il) 4, and il-5 levels in the serum were determined using elisas.Results.The expression of dectin-2 and tnf-α was increased in the myocardium in ami, and the susceptibility to ventricular arrhythmia (va) was increased.The induction rate of va was significantly decreased by etanercept.Compared with those in the sham-surgery group, the ami group showed significantly higher serum tnf-α and ifn-γ levels and lower il-4 and il-5levels.Conclusion.Dectin-2 intensifies the activation of the tnf-α immune reaction through the th1 differentiation, which may increase vulnerability to va in ami.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Effects of Sulcus Vocalis Depth on Phonation in Three-Dimensional Fluid-Structure Interaction Laryngeal Models

Sulcus vocalis is an indentation parallel to the edge of vocal fold, which may extend into the cover and ligament layer of the vocal fold or deeper.The effects of sulcus vocalis depth d on phonation and the vocal cord vibrations are investigated in this study.The three-dimensional laryngeal models were established for healthy vocal folds (0 mm) and different types of sulcus vocalis with the typical depth of 1 mm, 2 mm, and 3 mm.These models with fluid-structure interaction (fsi) are computed numerically by sequential coupling method, which includes an immersed boundary method (ibm) for modelling the glottal airflow, a finite-element method (fem) for modelling vocal fold tissue.The results show that a deeper sulcus vocalis in the cover layer decreases the vibrating frequency of vocal folds and expands the prephonatory glottal half-width which increases the phonation threshold pressure.The larger sulcus vocalis depth makes vocal folds difficult to vibrate and phonate.The effects of sulcus vocalis depth suggest that the feature such as phonation threshold pressure could assist in the detection of healthy vocal folds and different types of sulcus vocalis.

Journal: Applied Bionics and Biomechanics (2021)
Publication types: Research Article;
Effects of Stress on Osteoblast Proliferation and Differentiation Based on Endoplasmic Reticulum Stress and Wntβ-Catenin Signaling Pathway

In order to investigate the effect of fluid shear stress on the proliferation of osteoblasts and the regulatory role of the wnt/ β ‐catenin signaling pathway in cell proliferation, a new method based on endoplasmic reticulum stress and wnt/ β ‐catenin signaling pathway stress‐mediated was proposed.Taking mg63 osteoblasts as the research object, they were inoculated on glass slides (g group), polished titanium sheets (p group), and sandblasted acid‐base treated pure titanium sheets (s group).In addition, fss of 0 dunes/cm 2 (static group) and 12 dunes/cm 2 (stress group) were given, respectively.Then, quantitative reverse transcription‐pcr (rt‐q pcr) and western blot were used to detect the m rna and protein expressions of low‐density lipoprotein receptor‐related protein 5 (lrp5) and β ‐catenin in mg63 cells.The results showed that the expression levels of β ‐catenin m rna and protein in cells in the stress group were significantly increased ( p &lt; 0.05), and the protein expression level of lrp5 was significantly decreased ( p &lt; 0.05).The expression level of lrp5 in group s was greatly inhibited, while the expression level of β ‐catenin was significantly upregulated.Therefore, fss can stimulate the expression of lrp5 and β ‐catenin in osteoblasts.Fluid shear stress can promote osteoblast proliferation in vitro; the wnt/ β ‐catenin signaling pathway is involved in regulating fluid shear stress to promote osteoblast proliferation.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Effects of Shenkang Injection Combined with Jinshuibao on Early Diabetic Nephropathy and Effects on Coagulation Fibrinolysis System and Urinary Protein

To explore the effect of shenkang injection (ski) combined with jinshuibao for early diabetic nephropathy (dn) and its effect on the coagulation fibrinolysis system and urinary protein.Methods.136 patients with early dn admitted to our hospital from march 2018 to october 2019 were divided into the observation group (n = 68) and the control group (n = 68) randomly.On the basis of the conventional treatment, the control group was treated with ski, and the observation group was treated with ski and jinshuibao.Two weeks later, the therapeutic effects of the 2 groups were compared.The prothrombin time (pt), activated partial thromboplastin time (aptt), thrombin time (tt), fibrinogen (fib), tissue plasminogen activator (t-pa), plasminogen activator inhibitor-1 (pai-1), and d-dimer (d-d) were observed and compared before and after the treatment.24 hour urine total protein (24 h-utp), urine albumin excretion rate (uaer), and urine β2 microglobulin (β2-mg) were measured and compared before and after the treatment.Adverse reactions in the two groups were recorded during the treatment.Results.The effective rate of the observation group after treatment was 92.65% higher than the control group 79.41%.The difference was statistically significant ( p &lt; 0.05 ).The levels of pt, aptt, tt, fib, pai-1, and d-d in the two groups after treatment were lower, and t-pa levels after treatment were higher than those before, and all of the above indicators were significantly changed in the observation group than in the control group.The difference was statistically significant ( p &lt; 0.05 ).The 24 h-utp, uaer, and β2-mg in the two groups after treatment were lower than those before, and all of the above indicators were significantly changed in the observation group than in the control group.The difference was statistically significant ( p &lt; 0.05 ).There was no statistically significant difference during the treatment for 2 groups in terms of adverse reactions.The difference was statistically significant ( p &gt; 0.05 ).Conclusion.Ski combined with jinshuibao has a significant effect in the treatment of early dn, which can reduce the risk of hyperfunction of coagulation and fibrinolysis system, further reduce the content of urine protein, and delay the process of dn.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Effects of Ruanmailing in Blocking Early Stages of Atherosclerosis by TNF-i Regulation via Kir2.1

Ruanmailing oral solution consists of 16 herbs, has anti-lipid peroxidation activity, protects vascular endothelial cells, and improves vascular elasticity.It is an effective drug for the treatment of atherosclerosis (as).The objective of this study was to investigate the mechanism underlying the antiatherosclerotic effects of ruanmailing oral solution.Methods.Macrophages were isolated, cultured, and divided into the macrophage control; macrophage foam cell; and low-, medium-, and high-concentration ruanmailing groups.Cell proliferation was analyzed by cell counting kit-8 (cck-8) assay, and the expression levels of inward-rectifier potassium ion channel 2.1 (kir2.1) and tumor necrosis factor (tnf)-α were detected by reverse transcription-polymerase chain reaction (rt-pcr) and western blot analyses.Results.Cck-8 assay results showed that the tested concentrations of ruanmailing solution did not affect macrophage proliferation.Rt-pcr and western blot assays indicated that tnf-α expression increased significantly with the formation of macrophage foam cells (p &lt; 0.05).In addition, significant decreases in kir2.1 and tnf-α expression were observed following treatment with various concentrations of ruanmailing (p &lt; 0.05).Conclusion.Based on the results, ruanmailing affects macrophage foam cell formation by regulating kir2.1 expression, which in turn reduces tnf-α expression and exerts antiatherosclerotic effects.These findings provide a scientific basis for the use of traditional chinese medicine for as treatment.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Effects of Nifedipine and Labetalol Combined with Magnesium Sulfate on Blood Pressure Control, Blood Coagulation Function, and Maternal and Infant Outcome in Patients with Pregnancy-Induced Hypertension

The purpose is to investigate the influence of nifedipine, labetalol, and magnesium sulfate on blood pressure control, blood coagulation, and maternal and infant outcome in those suffering from pregnancy-induced hypertension (pih).Methods.From january 2019 to april 2021, 100 participants with pih in our center were randomly assigned to a control group and a research group.As a control, nifedipine combined with magnesium sulfate was administered.Nifedipine, labetalol, and magnesium sulfate were administered to the research group.The curative effect, blood pressure level, blood coagulation function, vascular endothelial function, and pregnancy comparisons were made between the two groups.Results.Based on the results of the study, the effective rate totaled 92.00%, while as for the control group, it was 80.0%, which indicates that there was a statistically significant difference between the effective rates of the research group and that of the control group, and the difference was statistically significant ( p &lt; 0.05 ).Blood pressure and blood coagulation function did not differ significantly between the two groups before treatment, and the difference was not statistically significant ( p &gt; 0.05 ).After treatment, both groups experienced a significant drop in systolic and diastolic blood pressure.After treatment, a higher pt index was found in the research group than in the control group.Likewise, the fbg, d-d, and plt were lower compared to those in the control group, and the difference was statistically significant ( p &lt; 0.05 ).Neither group had significantly different vascular endothelial function before treatment, and the difference was not statistically significant ( p &gt; 0.05 ).After treatment, the et-1 of the two groups decreased, and the level of no increased.There was a lower et-1 in the research group than in the control group as well as a higher no level in the research group than in the control group, and the difference was statistically significant ( p &lt; 0.05 ).Compared with the pregnancy outcome, in comparison to the controls, the research group had a higher vaginal delivery rate.Significantly, fewer cases of fetal distress, intrauterine asphyxia, and placental abruption were reported in the research group than in the control group, and the difference was statistically significant ( p &lt; 0.05 ).Conclusion.Nifedipine, in combination with magnesium sulfate and labetalol, is effective at treating pih, reducing blood pressure, improving blood coagulation, preventing cardiovascular events and vascular endothelial function, and further improve the pregnancy outcome.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Effects of Enalapril on TLR2/NF-κB Signaling Pathway and Inflammatory Factors in Rabbits with Chronic Heart Failure

Chronic heart failure (chf) refers to the state of persistent heart failure, which is a complex clinical syndrome of various advanced heart diseases.The toll-like receptor 2 (tlr2)/nuclear transcription factor-κb (nf-κb) signal transduction pathway is one of the pathological mechanisms of chf.Adriamycin can significantly induce the upregulation of tlr2 expression.Angiotensin-converting enzyme inhibitors (acei) are commonly used drugs for the treatment of chf.In our study, the chf model was established by injection of doxorubicin into the rabbit ear vein.The effect of enalapril on the tlr2/nf-κb signaling pathway in chf rabbits has been analyzed and determined.Our research results showed that enalapril reduced the inflammatory response by inhibiting the activation of the tlr2/nf-κb signaling pathway, thereby improving cardiac structure, myocardial remodeling, and cardiac function.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Research Article;
Effects of Early Weight-Bearing Treadmill Training Combined with Pre-Emptive Analgesia on Femoral Fracture Recovery

The effect of pre‐emptive analgesia plus early weight‐bearing treadmill training (ewbtt) on healing and motor function recovery of femoral shaft fracture is not clear.Methods .A total of 60 sd male rats were randomly allocated into 4 groups: group a (pre‐emptive analgesia with ewbtt), group b (pre‐emptive analgesia with delayed weight‐bearing treadmill training, dwbtt), group c (pre‐emptive analgesia with no weight‐bearing), and group d (ewbtt with no pre‐emptive analgesia).All rats were molded by internal fixation with kirschner wire after right femoral shaft fracture.In groups a, b, and c, tramadol was intramuscularly injected 15 minutes before surgery.Ewbtt was performed at day 1 postoperatively in groups a and d, and dwbtt was performed at day 14 postoperatively in group b.Oblique plate test was accomplished to assess hindlimb motor function recovery of rats in each group.Status of fracture healing was assessed through digital radiography (dr).Hematoxylin‐eosin (he) staining and immunohistochemistry of bone morphogenetic protein‐2 (mbp‐2) and vascular endothelial growth factor (vegf) in callus were performed to explore fracture healing.The expression of bmp‐2 and vegf protein in quadriceps femoris muscle was detected by western blot technique and m rna expression of bmp‐2 and vegf in callus ascertained via reverse transcription‐polymerase chain reaction (rt‐pcr) technique.Results .For oblique plate test, rats in group a outperformed those in groups b and c at all time points after operation.Dr image revealed that large numbers of callus growth, blurred fracture line, and obvious continuous callus passing through the fracture line can be found in group a at day 28 postoperatively, which is the best healing status among all groups.He staining of callus confirmed the optimal effect of healing for rats in group a.Vegf and bmp‐2 expression by immunohistochemistry showed a significantly higher positive score for callus in group a while those in group c being the lowest at all time points postoperatively.Significantly higher expression level of vegf and bmp‐2 protein was detected in quadriceps femoris muscle from group a, which exceeded those in all other groups at all time points.Rt‐pcr testing proved the highest expression of bmp‐2 and vegf m rna in callus of rats from group a, significantly higher than those of other groups.Conclusions .Both pre‐emptive analgesia and ewbtt can effectively invoke the expression of vegf and bmp‐2 and promote recovery of hindlimb locomotor function in rats with femoral fracture, and the combination of them leads to more superior results.

Journal: Evidence-Based Complementary and Alternative Medicine (2023)
Publication types: Research Article;
Effects of DNA Immunoadsorption Combined with Medication on Immune Function and Renal Function in Patients with Systemic Lupus Erythematosus

At present, glucocorticoids combined with cyclophosphamide are still used for the clinical treatment of systemic lupus erythematosus (sle).However, long-term practice has shown that drug treatment currently has the phenomena of long treatment duration, uncontrollable conditions in a short period of time, and unsatisfactory efficacy.Dna immunoadsorption therapy is a newly developed therapy.The combination of drugs and dna immunoadsorption has been reported for the treatment of slen in clinics for a long time.In this study, we observed the effects of dna immunoadsorption combined with drug therapy on immune function and renal function in patients with systemic lupus erythematosus (sle).The results showed that the dna immunosorbent assay combined with medication in the treatment of sle could quickly and specifically remove pathogenic substances from patients, improve renal function, immune function, and complement levels in patients, and help to relieve disease activity.

Journal: Journal of Environmental and Public Health (2023)
Publication types: Research Article;