syedzayyan/paper_mill_benchmark huggingface dataset:
High levels of serum IL-10 indicate disease progression, extramedullary involvement, and poor prognosis in multiple myeloma.

Multiple myeloma (mm) is a common malignant hematological tumor in adults, which is characterized by clonal malignant proliferation of plasma cells in the bone marrow and secretion of a large number of abnormal monoclonal immunoglobulins (m protein), leading to bone destruction, hypercalcemia, anemia, and renal insufficiency (alexandrakis et al., 2015; yang et al., 2018).Since a large number of new drugs, represented by proteasome inhibitors and immunomodulators, have been successfully used to treat mm, treatment efficacy and survival of patients have been significantly improved.However, due to the high heterogeneity of this disease, patients have responded differently to treatments with these new drugs (palumbo and anderson, 2011; wang et al., 2016; huang et al., 2020).Growth and survival of mm cells depend on the bone marrow microenvironment, especially numerous inflammatory cytokines secreted by myeloma cells and bone marrow stromal cells, such as vascular endothelial growth factor (vegf), interleukin (il)‍-6, transforming growth factor-‍β (tgf‍‍-‍‍β), and il-10.These cytokines can promote the growth of myeloma cells, induce angiogenesis, and inhibit antitumor immunity, and are often linked to patient prognosis (kumar et al., 2017).In this era of new drugs, the prognostic values of the serum levels of these cytokines in mm need further evaluation.

Journal: Journal of Zhejiang University. Science. B (2022)
Publication types: Journal Article
Learned value and predictiveness affect gaze but not figure assignment.

Many factors affect figure-ground segregation, but the contributions of attention and reward history to this process is uncertain.We conducted two experiments to investigate whether reward learning influences figure assignment and whether this relationship was mediated by attention.Participants learned to associate certain shapes with a reward contingency: during a learning phase, they chose between two shapes on each trial, with subsets of shapes associated with high-probability win, low-probability win, high-probability loss, and low-probability loss.In a test phase, participants were given a figure-ground task, in which they indicated which of two regions that shared a contour they perceived as the figure (high-probability win and low-probability win shapes were pitted against each other, as were high-probability loss and low-probability loss shapes).The results revealed that participants had learned the reward contingencies and that, following learning, attention was reliably drawn to the optimal stimulus.Despite this, neither reward history nor the resulting attentional allocation influenced figure-ground organization.

Journal: Attention, perception & psychophysics (2021)
Publication types: Journal Article
In Situ Grazing-Incidence SAXS Investigation of Thermal-Induced Self-Assembly Process of PS-b-PMMA Films Deposited on Surface-Modified Substrate.

Directed self-assembly of block copolymers (bcps) is widely investigated for its potential application in surface patterning.The self-assembly kinetics of bcp based on modified layers is the key to realizing structural control for obtaining highly ordered lamellar grains.In this study, morphological evolution of ps-b-pmma films during the thermal-induced self-assembly process was investigated via the in situ grazing-incidence small-angle x-ray scattering (gisaxs) technique.In the first heating stage, reorientation of lamellar grains occurred as the temperature increased above the glass transition temperature.Then, a fast increase in the lamellar repeat period l0was observed, which is considered as a phase separation process.Whereas the size of the lamellar grain ξ was observed to have rapidly increased in the stage wherein the temperature was held at 230 °c, the l0was almost constant.This result indicates that the formation of ordered structure in ps-b-pmma films was mainly determined by two periods: phase separation of block molecules followed by growth of grains in the nanodomain.In addition, it was interesting that the better-order nanodomains were obtained with thermal annealing at a faster heating rate.These findings suggest that accomplishing ordered structure control in a large area could be realized via the design of a proper heating profile.

Journal: The journal of physical chemistry. B (2022)
Publication types: Journal Article
Influence of Appeal Type and Message Framing on Residents' Intent to Engage in Pro-Environmental Behavior.

In this intervention study, we examined the effects and psychological processes of different types of messaging intended to promote waste-separation behavior on the intent of residents to separate household waste and to engage in other pro-environmental behaviors (pebs).Based on three studies (one survey with 76 residents and two experiments with 446 residents) in china, our results revealed that environmental appeals increased residents' intent to separate waste and engage in other pebs, whereas monetary incentives had no effect.Although the main effects of the framing of messages on the intent to separate waste and other pebs were not significant, we found an interactive effect of appeal type and message framing.When matched with loss framing, an environmental appeal indirectly generated a stronger positive impact by stimulating an individual's environmental risk perception.When monetary incentives matched with loss framing, individual pro-environmental identity weakened, thereby inhibiting the positive impact on intent to separate waste.With this study, we provide important theoretical support for the selection and optimization of waste-separation intervention strategies and guidance for persuading residents to engage in more pebs.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article
Utilizing Red Spotted Apollo Butterfly Transcriptome to Identify Antimicrobial Peptide Candidates againstPorphyromonas gingivalis.

Classical antibiotics are the foremost treatment strategy against microbial infections.Overuse of this has led to the evolution of antimicrobial resistance.Antimicrobial peptides (amps) are natural defense elements present across many species including humans, insects, bacteria, and plants.Insect amps are our area of interest, because of their stronger abilities in host defense.We have deciphered amps from an endangered species parnassius bremeri, commonly known as the red spotted apollo butterfly.It belongs to the second largest insect order lepidoptera, comprised of butterflies and moths, and lives in the high altitudes of russia, china, and korea.We aimed at identifying the amps from the larvae stages.The rationale of choosing this stage is that the p.Bremerilarvae development occurs at extremely low temperature conditions, which might serve as external stimuli for amp production.Rna was isolated from larvae (l1 to l5) instar stages and subjected to next generation sequencing.The transcriptomes obtained were curated in in-silico pipelines.The peptides obtained were screened for requisite amp physicochemical properties and in vitro antimicrobial activity.With the sequential screening and validation, we obtained fifteen candidate amps.One peptide tps-032 showed promising antimicrobial activity against porphyromonas gingivalis, a primary causative organism of periodontitis.

Journal: Insects (2021)
Publication types: Journal Article
Maintenance plasma exchange treatment for muscle specific kinase antibody positive myasthenia gravis patients.

Anti-muscle specific kinase antibody positive myasthenia gravis (mu sk mg) is often characterized by a relatively severe and progressive course, refractoriness to standard myasthenia gravis (mg) medications, and an increased risk of myasthenic crisis.We report here successful management of three mu sk mg patients using maintenance therapeutic plasma exchange (tpe) treatment for up to 4.5 years.Materials the study was a 5-year retrospective review of all mg patients treated with tpe between 2008 and 2013 at university of michigan.Inclusion criteria of mu sk mg were positive for anti-mu sk antibodies and a diagnosis of mu sk mg by staff neurologists.Patient data included age, gender, diagnostic testing results, medications, and the dates and response to tpe treatments.Results a total of 153 mg patients underwent at least one course of tpe between 2008 and 2013.A total of 12 patients (7.8%) were positive for anti-mu sk antibodies.Patients were predominantly female (83.3%) and a median age of onset was 46-years old.Three mu sk mg patients were successfully managed with maintenance tpe.Conclusion maintenance tpe may be an effective option for mu sk mg patients.The key of successful maintenance treatment at our institution has been to tailor the tpe frequency for each individual, and to modify the treatment interval in conjunction with medical management.

Journal: Journal of clinical apheresis (2015)
Publication types: Case Reports;Evaluation Study;Journal Article
Outcomes of Multiple Runs of Extracorporeal Membrane Oxygenation: An analysis of the Extracorporeal Life Support Registry.

When patients deteriorate after decannulation from extracorporeal membrane oxygenation (ecmo), a second run of extracorporeal support may be considered.However, repeat cannulation can be difficult and poor outcomes associated with multiple ecmo runs are a concern.The aim of this study was to evaluate outcomes and identify factors associated with survival and mortality in cases of multiple runs of extracorporeal membrane oxygenation.Design retrospective cohort analysis of the extracorporeal life support organization registry.Setting the extracorporeal life support organization's registry was queried for neonates, children, and adults receiving 2 or more runs of ecmo during the same hospitalization, for any indication, from 1998 to 2015.Patients 1,818 patients from the extracorporeal life support organization registry.Results of the 1,818 patients, 1,648 underwent 2 runs and 170 underwent 3 or more runs of ecmo.The survival to discharge rate was 36.7% for 2 runs and 29.4% for 3 or more runs.No significant differences in survival were detected in analysis by decade of ecmo run (p = 0.21).Pediatric patients had less mortality than adults (or: 0.45, 95%ci: 0.24-0.82).Cardiac support on the first run portrayed worse mortality than pulmonary support regardless of final run indication (or:1.38, 95%ci: 1.09-1.75).Across all age groups, patients receiving pulmonary support on the last run tended to have higher survival rates regardless of support type on the first run.The only first run complication independently predictive of mortality on the final run was renal complications (or: 1.60, 95%ci: 1.28-1.99).Conclusions though the use of multiple runs of ecmo is growing, outcomes remain poor for most cohorts.Survival decreases with each additional run.Patients requiring additional runs for a pulmonary indication should be considered prime candidates.Renal complications on the first run significantly increases the risk of mortality on subsequent runs, and as such, careful consideration should be applied in these cases.

Journal: Journal of intensive care medicine (2022)
Publication types: Journal Article
Biomineralized hydrogel DC vaccine for cancer immunotherapy: A boosting strategy via improving immunogenicity and reversing immune-inhibitory microenvironment.

The postoperative recurrence and metastasis of triple negative breast cancer (tnbc) remain one fatal reason for the failure of clinical treatments.Although the rise of immunotherapy has brought hopes for reducing postoperative recurrence and potential metastasis, the low immune response and immunosuppression of tumor microenvironment (tme) still restrain its extensive application.Herein, we reported a boosting strategy by improving immunogenicity and reversing suppressive tme to realize efficient immunotherapy of tnbc.In this work, a ca co3biomineralized hydrogel dc vaccine was synthesized by fixing the membrane proteins of 4t1 cells-dcs fusion cells (fp) into biomineralized silk fibroin hydrogel.On one side, the fp-containing biomineralized hydrogel vaccine (sh@fp@ca co3) has increased immunogenicity by providing a wide variety of tumor-associated antigens (taas) and realizing long-term protein release for dcs maturation and t cell activation.On the other side, the introduction of ca co3would increase the p h of tme and promote the polarization of m2-type macrophages to m1-type macrophages, thus reversing the immune-inhibitory microenvironment and relieving the immunosuppressive effect on t cells.The results indicate that the biomineralized hydrogel vaccine shows excellent immune activation effects by simultaneously enhancing the immunogenicity and reversing the immunosuppression tme, which provides a promising strategy for cancer immunotherapy.

Journal: Biomaterials (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The Roles of Host Noncoding RNAs inMycobacterium tuberculosisInfection.

Tuberculosis remains a major health problem.mycobacterium tuberculosis, the causative agent of tuberculosis, can replicate and persist in host cells.Noncoding rnas (nc rnas) widely participate in various biological processes, including mycobacterium tuberculosisinfection, and play critical roles in gene regulation.In this review, we summarize the latest reports on nc rnas (micro rnas, pi rnas, circ rnas and lnc rnas) that regulate the host response against mycobacterium tuberculosisinfection.In the context of host-mycobacterium tuberculosisinteractions, a broad and in-depth understanding of host nc rna regulatory mechanisms may lead to potential clinical prospects for tuberculosis diagnosis and the development of new anti-tuberculosis therapies.

Journal: Frontiers in immunology (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Circulating Tumor Cells Develop Resistance to TRAIL-Induced Apoptosis Through Autophagic Removal of Death Receptor 5: Evidence from an In Vitro Model.

Circulating tumor cells (ctcs) in the peripheral blood are the precursors to distant metastasis but the underlying mechanisms are poorly understood.This study aims at understanding the molecular features within ctcs, in relation to their metastatic potential.Using in vitro ctc models, in which breast cancer cell lines were cultured in non-adherent conditions simulating the microenvironment in the blood stream, we found that the suspension culture resulted in resistance to tnf-related apoptosis inducing ligand (trail)-mediated cell death.Such a resistance was directly correlated with a reduction in surface and total levels of dr5 protein.In the non-adherent state, the cells underwent a rapid autophagic flux, characterized by an accumulation of autophagosome organelles.Notably, dr5 was translocated to the autophagosomes and underwent a lysosomal degradation.Our data suggest that ctcs may evade the tnf cytokine-mediated immune surveillance through a downregulation of the death receptor (dr) expression.The data warrants further studies in cancer patients to find the status of drs and other molecular features within primary ctcs, in relation to disease progression or chemoresistance.

Journal: Cancers (2019)
Publication types: Journal Article
Severe re-expansion pulmonary edema after conventional cardiac surgery: Identification and management.

Re-expansion pulmonary edema (repe) is a recognized but rare complication of lung re-inflation after pathologic collapse or intentional deflation.The presentation of repe may be highly variable, ranging from a clinically asymptomatic, incidental radiologic finding to acute respiratory failure accompanied by severe, life-threatening hypoxemia.With the current report, we present a patient with severe aortic insufficiency, severe mitral regurgitation, coronary artery disease, pulmonary hypertension, who underwent aortic valve replacement, mitral valvuloplasty, coronary artery bypass grafting, and developed at the immediate post- operative period severe respiratory failure due to repe, requiring venous-venous extracorporeal membrane oxygenation (vv-ecmo).

Journal: Journal of cardiac surgery (2019)
Publication types: Case Reports;Journal Article
A study on drinking water quality in different income groups of Vizianagaram region of India.

Portable clean water consumption is the basic right of every individual.The major global concern is water pollution which can cause mortality.Change in physicochemical characteristics in drinking water is not only a pollution problem, but the presence of antibiotic-resistant microbes is also a significant issue.The study was carried out to assess the physicochemical and microbiological quality of the reservoir, municipality-supplied water, and bottled water.A total of 100 samples were collected from different income classes (higher, medium, and low) groups.The experiments were carried out based on the guidelines of apha.In the present study, 40% of samples have been found to be contaminated with bacteria such as escherichia coli, vibrio cholerae, and enterobacter aerogenes.Moreover, these bacteria also showed antibiotic resistance to certain drugs.The percentage of isolated bacterial strains was resistant to amoxicillin and ampicillin antibiotics.The statistical analysis of the chi-square test states that there is a significant correlation between e.Coli and other microbes (p ≤ 0.5).This study gives a piece of baseline information about the prevalence of antibiotic-resistant bacteria and focuses on the improvement of water from purification before reaching the consumer.

Journal: Journal of water and health (2022)
Publication types: Journal Article
Imaging of Dentate Nucleus Pathologies: A Case Series.

The dentate nucleus is the largest cerebellar nucleus, and it controls cognition and voluntary movement.It is found in each cerebellar hemisphere medially and posterolateral to the lateral ventricle.Pathologies of the dentate nucleus can be detected using computed tomography and magnetic resonance imaging of the brain.Here, we present a case series of seven different dentate nucleus diseases and their neuroimaging findings recovered from archives of our institution.

Journal: Journal of neurosciences in rural practice (2022)
Publication types: Journal Article
Early-stage iron deficiency alters physiological processes and iron transporter expression, along with photosynthetic and oxidative damage to sorghum.

Iron (fe) starvation in strategy ii plants is a major nutritional problem causing severe visual symptoms and yield reductions.This prompted us to investigate the physiological and molecular consequences of fe deficiency responses at an early stage in sorghum plants.The fe-starved sorghum did not show shoot biomass reduction, but the root length, biomass, and chlorophyll synthesis were severely affected.The chlorophyllafluorescence analysis showed that the quantum yield efficiency of psii (fv/fm) and photosynthesis performance index (pi_abs) in young leaves significantly reduced in response to low fe.Besides, fe concentration in root and shoot significantly declined in fe-starved plants relative to fe-sufficient plants.Accordingly, this fe reduction in tissues was accompanied by a marked decrease in ps-release in roots.The q pcr experiment showed the downregulation of sb dmas2(deoxymugineic acid synthase 2),sb nas3(nicotianamine synthase 3), and sb ysl1(fe-phytosiderophore transporter yellow stripe 1) in fe-deprived roots, suggesting that decreased rhizosphere mobilization of fe(iii)-ps contributes to reduced uptake and long-distance transport of fe.Thecis-acting elements of these gene promoters are commonly responsive to abscisic acid and methyl jasmonate, while sb ysl1additionally responsive to salicylic acid.Further, antioxidant defense either through metabolites or antioxidant enzymes is not efficient in counteracting oxidative damage in fe-deprived sorghum.These findings may be beneficial for the improvement of sorghum genotypes sensitive to fe-deficiency through breeding or transgenic approaches.

Journal: Saudi journal of biological sciences (2021)
Publication types: Journal Article
A novel 2-piece rose spiral curve model: Application in epileptic EEG classification.

This paper aimed to provide an innovative 2d phase space model and evaluate its performance in categorizing electroencephalogram (eeg) signals of normal and epileptic patients.The main contributions of the current study are as follows.(1) for the first time, it was proposed a new 2d model based on a 2-piece rose spiral curve (rsc) in eeg analysis.(2) the trajectory patterns of the model were examined for signals of different natures, including constant, periodic, random, and eeg.(3) it was presented some benchmarks for quantifying the trajectory patterns.(4) applying these measures, support vector machine, naïve bayes, ada boost, and k-nearest neighbor were used in the epileptic eeg classification problem to estimate the method efficiency.Bonn database, which takes account of eeg signals of healthy, in the course of an epileptic seizure occurrence, and seizure-free cases, was assessed.The results indicated that the proposed framework provided a correct rate of 100% for recognizing healthy subjects and the eegs with seizure activity.Additionally, seizure-free brain activity was classified with an accuracy of 96.7%.To conclude, the proposed rsc model can be suitable for serving as a computer-aided diagnosis tool for epileptic seizures.

Journal: Computers in biology and medicine (2022)
Publication types: Journal Article
Dihydroartemisinin Inhibits TGF-β-Induced Fibrosis in Human Tenon Fibroblasts via Inducing Autophagy.

The formation of hypertrophic scars (hs) can result in the failure of glaucoma surgery, and fibrosis is known to be closely associated with the progression of hs.Dihydroartemisinin (dha) has been reported to inhibit the progression of fibrosis; however, whether dha can alleviate the formation of hs remains unclear.Methods in the present study, in order to examine the effects of dha on the progression of hs, human tenon's capsule fibroblasts (htfs) were isolated from patients who underwent glaucoma surgery.In addition, western blot analysis, microtubule associated protein 1 light chain 3 α staining and reverse transcription-quantitative pcr were performed to detect protein and m rna expression levels in the htfs, respectively.Cell proliferation was detected by ki67 staining.Flow cytometry was used to examine apoptosis and reactive oxygen species (ros) levels in the htfs.Results the results revealed that tgf-β promoted the proliferation and fibrosis of htfs; however, dha significantly reversed the effects of tgf-β by increasing cell autophagy.In addition, dha notably induced the apoptosis of tgf-β-stimulated htfs by increasing the ros levels, while these increases were partially reversed by 3-methyladenine.Furthermore, dha notably increased the expression of micro rna (mi r)-145-5p in htfs in a dose-dependent manner.Conclusion the present study demonstrated that dha inhibits the tgf-β-induced fibrosis of htfs by inducing autophagy.These findings may aid in the development of novel agents for the prevention of the formation of hs following glaucoma surgery.

Journal: Drug design, development and therapy (2021)
Publication types: Journal Article