syedzayyan/paper_mill_benchmark huggingface dataset:
Application of Prescription Reviews for Traditional Chinese Medicine to Improve Medical Disputes and Patient Satisfaction

Medical disputes and patient satisfaction are related to inappropriate prescribing practices.We aim to investigate the clinical application of prescription reviews for traditional chinese medicine (tcm).Method.Tcm prescriptions performed prescription reviews in 372 patients from the year 2019 to 2020 were set as the observation group and those from the year 2017 to 2018 without prescription reviews as the control group (n = 341).According to the criteria for assessing prescription quality in chinese hospitals (capqch) items, “irrational” and “rational” tcm prescriptions were determined mainly based on the following category: nonstandard prescriptions, inappropriate prescriptions, and hypernormal prescriptions.The incidence of medical disputes and the degree of patient satisfaction were compared between the two groups.Result.No difference was found in age and gender between the control group and the observation group.The number of irrational tcm prescriptions from the year 2017 to 2020 was 6, 8, 2, and 3, respectively, with the percentage of 3.725%, 4.480%, 1.201%, and 1.446%.The irrational rate in the observation group (1.344%) was significantly lower than that in the control group (4.106%).Specifically, a higher rate of nonstandard prescriptions was revealed in the control group as compared with the observation group.Moreover, a reduced incidence of medical disputes was revealed in the observation group relative to the control group accompanying with the increased degree of patient satisfaction.Conclusion.Prescription reviews have high application value in the management of chinese pharmacies, which can improve the rationality of prescriptions, increase patient satisfaction, and reduce medical disputes.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Application of Melatonin with N-Acetylcysteine Exceeds Traditional Treatment for Acetaminophen-Induced Hepatotoxicity

Acetaminophen (apap) overdose is one of the leading causes of acute liver damage.Given n-acetylcysteine (nac) and melatonin (mlt) both have an attenuated value for apap-induced liver toxification, where an optimized integrated treatment has not been well deciphered.Here, by giving a single dose of apap (500 mg/kg) to wild-type male mice, combined with a single dose of 500 mg/kg nac or 100 mg/kg mlt separately as the therapeutic method, this study aimed to investigate the effects of nac and melatonin (mlt) alone or combined on acetaminophen (apap)-induced liver injury.In this study, nac and mlt both partially have an alleviated function in apap-challenged liver injury.However, mlt’s add-on role strengthens the hepatoprotective effect of nac on apap-induced liver damage and resolute the inflammatory infiltration.Meanwhile, the combination of two reagents attenuates the decreased glutathione (gsh) and activation of the p38/jnk pathway.The combination of mlt and nac can further ameliorate apap-induced liver injury, which provides a novel strategy for drug-induced liver injury (dili).

Journal: Emergency Medicine International (2022)
Publication types: Research Article;
Application of Emergency Specialist Nursing Combined with Green Channel Mode in Patients with Limb Amputation

The treatment of limb amputation is always a challenge to emergency medical staff.The success of replantation of severed limbs requires not only emergency professional nursing measures but also rapid transport against time.We that found emergency specialist nursing combined with green channel mode can effectively improve the success rate of amputated limb replantation surgery.Methods.From september 2017 to august 2020, the medical records of 80 patients with severed limb replantation treated by the emergency department of our hospital were collected and divided into the control group and the experimental group.36 patients in the control group were emergency patients treated from september 2017 to may 2019.These patients did not take appropriate emergency specialist nursing measures and opened green channels at that time; the other 44 patients were in the experimental group, for emergency patients treated from june 2019 to august 2020.These patients have received emergency specialist care and opened a green channel.We recorded the gender, age, preoperative examination time, and success rate of amputated limb replantation surgery of the two groups of patients.Results.The age of the patients in the control group was 41.17 ± 8.00 years old, and the age of the patients in the experimental group was 41.07 ± 7.31 years old ( p &gt; 0.05 ).The preoperative examination time of the patients in the control group was 46.53 ± 4.11 min, and the preoperative examination time of the patients in the experimental group was 40.34 ± 5.85 min ( p &lt; 0.05 ); the replantation success rate of the control group was 72.2%, and the replantation success rate of the experimental group was 81.8% ( p &lt; 0.05 ).Conclusion.Standardized emergency specialist nursing measures combined with green channel mode can effectively shorten the preoperative examination time and help improve the success rate of amputated limb replantation surgery.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Clinical Study;
Application of Cross-Linked and Non-Cross-Linked Hyaluronic Acid Nano-Needles in Cosmetic Surgery

The common feature of non-cross-linked hyaluronic acid nano-needles is that they penetrate the skin and dissolve rapidly, and the non-cross-linked hyaluronic acid will migrate under the skin, so it is difficult to maintain the long-term expansion effect in a fixed position.In order to achieve the relatively long-term antiwrinkle effect, a kind of cross-linked and non-cross-linked compound hyaluronic acid microne was prepared.By inserting the microne under the skin, dissolving the non-cross-linked part under the skin and introducing the cross-linked gel particles under the skin, the effect of extending the microne was achieved.The mechanical properties, permeability, and degradation rate of cross-linked and non-cross-linked hyaluronic acid composite nano-needles were studied in detail.Experimental results show that the higher the content of cha, the slower the degradation rate of the microneedle, and the skin swelling of the ha_cha (1 : 1) microneedle is the most lasting.With the increase of cha content in microneedle matrix materials, the degree of epidermal expansion decreased.The preparation of cross-linked and non-cross-linked hyaluronic acid microneedles has the potential to be effectively used as dermal fillers in cosmetics or antiaging treatments.

Journal: International Journal of Analytical Chemistry (2022)
Publication types: Research Article;
Application of Calcium-Based Nanomaterials in Art Sculpture Reinforcement Technology

In order to solve the problem of the reinforcement effect of art sculpture, the author proposes the application of a calcium-based nanomaterial in the reinforcement process of art sculpture.This application mainly passes the unconfined compression test, direct shear test, penetration resistance test, and disintegration test, and an in-depth evaluation of the reinforcement effect of different calcium-based reinforcement agents on the site soil was carried out from the perspective of mechanical strength and water stability.The results showed the following: compared with the untreated samples, the unconfined compressive strength of the samples treated with nano-calcium oxide and nano-calcium hydroxide increased by 13.5% and 25.9%, respectively, and the cohesion increased by 69.8% and 97.7%.Conclusion.Calcium-based nanomaterials fill in the pores between soil particles to support the soil particles, which greatly improves the mechanical strength and water stability of the specimen.

Journal: International Journal of Analytical Chemistry (2022)
Publication types: Research Article;
Application of Artificial Intelligence in the Intervention of Sports on Adolescent Health Risk Behavior

Through school education to intervene in the behavior of adolescent health risk behaviors students and guide students to have a correct concept of quality and health, this paper uses artificial intelligence technology to mine students’ body language to analyze students’ behavior in quality education dance classes, so as to achieve effective intervention for ahrb students.Before the experimental study, ahrb students and normal students were mixed into groups in a ratio of not less than 1 : 18.The results of the study showed that the implementation of intervention strategies could reduce the recurrence of various risky behaviors in adolescents.When non-ahrb students and ahrb students intervene together, there will be no adverse effects on non-ahrb students.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Application of 3D Printing Technology and Porous Nano-Ceramic Decorative Sheet in Interior Landscape Design

In order to solve the problems that the traditional ceramic method is difficult to form porous ceramics with complex structures, the mold production cycle is long, and the cost is high, the authors propose the application of 3d printing technology and porous nano-ceramic decorative sheet in interior landscape design.Based on the use of photocuring molding technology to make high-precision regular resin molds, optimize the low-viscosity, high-solid content alumina ceramic slurry required by the gel injection molding process and form alumina ceramic blanks by means of a vacuum pressure process, so as to realize the net shape of complex structural porous ceramic parts.In view of the filling problem of ceramic slurry in complex structure in the process, the effects of slurry p h value, dispersant dosage, and vacuum pressurization process on ceramic molding were studied, and parameters such as porosity and compressive strength of the green body were tested.Experimental results show the following.Under the conditions of p h value of 9, mass fraction of dispersant of 0.4%, and vacuum pressure of 90 min, alumina ceramics with a volume fraction of 52% can be prepared, the porosity is 51.5%, and the compressive strength is 40.1 mpa.The ceramic material prepared by this process has complete structure and smooth surface and can be used as a process for preparing porous ceramic parts with complex structure.

Journal: International Journal of Analytical Chemistry (2022)
Publication types: Research Article;
Application Effect of Somatostatin Combined with Transnasal Ileus Catheterization in Patients with Acute Intestinal Obstruction and Advanced Gastric Cancer

To explore the application of somatostatin combined with nasal plug catheterization in patients with advanced gastric cancer and acute intestinal obstruction.Methods.This study included 94 cases of patients with acute intestinal obstruction and advanced gastric cancer, and according to the length of hospital stay, the patients were randomly divided into two groups: the control group and the study group, with 47 cases in each group.Based on the observations made by the team in the control group given somatostatin combined treatment, we observed two groups of patients with gastrointestinal function, serum index, quality of life, therapeutic effect, and adverse reactions.Results.Abdominal distention, abdominal pain duration, and normal exhaust time were significantly shorter in the study group than in the control group.The study group was higher than the control group in terms of gastrointestinal decompression volume, drainage volume, and abdominal circumference reduction within 24 hours ( p &lt; 0.05 ).After treatment, the levels of crp, ig a, lps, and fabp were lower than before, and the levels of crp, ig a, lps, and fabp in the former group were much lower than those in the latter group ( p &lt; 0.05 ).Compared with before treatment, the former giqli scale score was significantly higher than the latter ( p &lt; 0.05 ).After treatment, the efficiency is much higher than the latter ( p &lt; 0.05 ).After treatment, the former significantly lowers the incidence of postoperative complications of the latter ( p &lt; 0.05 ).Conclusion.For patients with advanced gastric cancer and acute intestinal obstruction, it is safe and feasible to use somatostatin combined with transnasal intestinal obstruction catheterization to restore gastrointestinal function, improve inflammatory response, and promote the improvement of quality of life with high safety and feasibility.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Clinical Study;
Application Effect of New Material after Surface Modification of Zirconia Ceramics and Analysis of Patient Evaluation

To explore the application effect of new material after surface modification of zirconia ceramics and patient evaluation.Methods.A total of 60 patients with tooth defect treated in our hospital from april 2020 to april 2021 were selected as the study subjects and randomly divided into the control group and experimental group, with 30 cases each.The patients in the control group were treated with glass-ceramics, and those in the experimental group received li si surface treatment, so as to compare the application effect and patients’ evaluation between the two groups.Results.Between the two groups, no obvious differences in surface loss, adhesive strength, and transmittance at 3 months, 6 months, and 1 year were not observed ( p &gt; 0.05 ); and after intervention, the score on dental aesthetics, hardness value, and occlusal force were obviously higher in the experimental group than in the control group ( p &lt; 0.001 ).Conclusion.The new material enables forming an acid etchable coating on the zirconia surface, increases the adhesive strength, and achieves an aesthetic degree that is welcomed by the patients; meanwhile, after grinding, the edge is defect free and the tightness is higher.Further research will help to establish a better solution for patients.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Clinical Study;
Application and Effect Evaluation of Nursing Risk Management in Nursing of Cardiovascular Medicine

Cardiovascular medicine patients have complex conditions and rapid progress.They will cause a variety of complications during the illness and are difficult to care for.In addition, the above departments have many treatment tools, complex nursing points, and nursing risks.Scientific risk management should be carried out to avoid the occurrence of adverse events.Existing studies incorporating nursing risk management into cardiovascular health care are incomplete.This paper aims to explore the analysis and research methods of nursing cardiovascular medicine applications and effects evaluation based on nursing risk management and deep learning.Through the observation and experiment of grouping 100 cardiovascular medicine patients in a hospital, the total satisfaction degree of the experimental group reached 90%, and the control group was only 48%, which is quite different in comparison.The factors affecting the occurrence of nursing risk have the characteristics of multiplicity, instability, and uncertainty.Therefore, in order to improve the nursing effect and the rescue rate, it is imperative to strengthen the nursing risk management and, at the same time, reduce the patient’s physical pain and nursing risk.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Apatinib Functioned as Tumor Suppressor of Synovial Sarcoma through Regulating miR-34a-5p/HOXA13 Axis

Synovial sarcoma is a rare malignant tumor.The role of apatinib in synovial sarcoma remains unclear.In this study, we aimed to determine the biological functions and the potential molecular mechanism of action of apatinib in synovial sarcoma.Methods.Sw982 cells were stimulated with apatinib.The relative expression of the genes was determined by performing q pcr.Protein levels were evaluated by western blot and immunohistochemistry assays.Proliferation, apoptosis, migration, and invasion of sw982 cells were determined by the cck-8 assay, clone formation assay, flow cytometry, wound healing, and the transwell assay, respectively.Additionally, sw982 cells were injected into mice to induce synovial sarcoma.Results.Apatinib decreased the proliferation, migration, and invasion but increased the apoptosis of sw982 cells.Apatinib repressed tumor growth in vivo and elevated mi r-34a-5p in sw982 cells.The inhibition of mi r-34a-5p repressed the reduction of proliferation, migration, and invasion and also the elevation of apoptosis in apatinib-treated sw982 cells.The luciferase activity decreased after cotransfection of the mi r-34a-5p mimic and the wild-type hoxa13 vector.Additionally, an increase in mi r-34a-5p repressed the levels of hoxa13 m rna and protein.Moreover, hoxa13 reversed these patterns caused by the inhibition of mi r-34a-5p in apatinib-treated sw982 cells.Conclusion.Apatinib elevated mi r-34a-5p and reduced hoxa13, leading to a significant decrease in proliferation, migration, and invasion, along with an enhancement of apoptosis in sw982 cells.Apatinib suppressed tumorigenesis and tumor growth in sw982 cells in vivo.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Antioxidant and Immunomodulatory Activities of Essential Oil Isolated from Anti-Upper Respiratory Tract Infection Formulation and Their Chemical Analysis

This study evaluates the in vitro antioxidant and immunomodulation activities of essential oils isolated from an anti-upper respiratory tract infection (urti) formulation with a view to their therapeutic potential.The chemical components of the essential oil were analysed by gas chromatography-mass spectrometry (gc-ms).The antioxidative activity of the oils was investigated with regard to their ability to scavenge dpph●, abts●+, and hydroxyl free radical (•oh).Their immunostimulatory activities were determined using murine macrophage cells.The main components of the oil with pharmacological and biological activities include 1,8-eucalyptol (42.9%), patchouli alcohol (19.9%), trans-erinolide (9.2%), and guaiacol (5%).The oils displayed high dpph, abts, and hydroxyl radical scavenging activities and anti-inflammatory activities by reducing tumour necrosis factor-α (tnf-α) and interleukin-6 (il-6) production.The results indicate that essential oils have the potential to be used in products for anti-urti treatment.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Angiopoietin-Like Protein 2 Is Increased in Obese Mouse Models of Lung Injury

To investigate the regulatory role of angiopoietin-1ike protein 2 (angptl 2) in the pathogenesis of acute respiratory distress syndrome (ards).Methods.A high-fat diet (hfd) and tail vein injection of 0.1 ml/kg oleic acid were used to induce acute lung injury (ali) and ards models, and male kunming mice were randomly divided into four groups: control group (injected with normal saline), ali group (injected with oleic acid), hfd group (injection of normal saline), and ards group (hfd+injection of oleic acid).The degree of lung injury was assessed by lung histopathology score and lung injury index.At the same time, the m rna and protein expression levels of angptl 2 in lung tissue were also detected to determine the relationship between angptl 2 and ards.Results.Lee’s index of the hfd group and ards group was significantly higher than that of the control group and ali group ( p &lt; 0.05 ), and the lung injury index of the ards group was significantly higher than that of the ali group.The expression of angptl 2 in the lung tissue of the ali group and ards group was significantly different, and the angptl 2 m rna level was the highest in the ards group.Immunohistochemistry showed that the alveolar walls of the ali group and ards group were severely collapsed, and the ards group had the greatest angptl 2 aggregation at the site of edema exudation.Conclusion.Collectively, obesity might be mediated by angptl 2 and promotes lung injury.Immunohistochemistry analysis showed that the expression of the receptor on alveolar walls was correlated with angptl 2, which increased alveolar wall permeability, edema fluid exudation, and alveolar wall collapse.Thus, angptl 2 might be a target for improving the treatment of ards.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Analysis on the Efficacy of Bronchial Artery Chemoembolization Combined with 125I Seed Implantation in the Therapy of Advanced Non-Small-Cell Lung Cancer Based on the Medical Database

To investigate the use and the efficacy of bronchial artery chemoembolization combined with 125i seed implantation in advanced non‐small‐cell lung cancer (nsclc) therapy based on the medical database.Methods .A total of 102 patients with advanced nsclc were randomly divided into two groups.The control group was treated with 125i seed implantation, and the observation group was treated with bronchial artery chemoembolization (bace) combined with 125i seed implantation based on medical database.The clinical efficacy, carcinoembryonic antigen (cea), cytokeratin 19 fragment antigen 21‐1 (cyfra21‐1), glycan antigen 125 (ca125), peripheral blood cd3+, cd8+, cd4+/cd8+ t cells, insulin‐like growth factor type 1 receptor (igf‐1r), s100 calcium‐binding protein a2 (s100a2), long‐term efficacy (time to disease progression, six‐month survival rate, and one‐year survival rate), and safety were then analyzed.Result .The disease remission rate in the observation group was 62.75%, which was higher than that in the control group (41.18%).After 1 month and 3 months of treatment, the levels of serum cyfra21‐1, cea, ca125, and igf‐1r were lower, while serum s100a2 was higher in the observation group than in the control group ( p &lt; 0.05).For safety assessment, we found that the incidences of neutropenia, thrombocytopenia, and gastrointestinal reactions had no statistical differences between two groups.The time to disease progression in the observation group was 129.85 d longer than that in the control group, 89.74 d, and the six‐month survival rate and 1‐year survival rate were higher in the observation group relative to the control group.Conclusion .Medical database‐based bace combined with 125i seed implantation in the therapy of advanced nsclc patients has definite efficacy with certain safety, which can enhance antitumor effect and prolong survival rate in advanced nsclc patients.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;