syedzayyan/paper_mill_benchmark huggingface dataset:
Optimized Platelet-Rich Fibrin With the Low-Speed Concept: Growth Factor Release, Biocompatibility, and Cellular Response.

Over the past decade, use of leukocyte platelet-rich fibrin (l-prf) has gained tremendous momentum in regenerative dentistry as a low-cost fibrin matrix used for tissue regeneration.This study characterizes how centrifugation speed (g-force) along with centrifugation time influence growth factor release from fibrin clots, as well as the cellular activity of gingival fibroblasts exposed to each prf matrix.Methods standard l-prf served as a control (2,700 revolutions per minute [rpm]-12 minutes).Two test groups using low-speed (1,300 rpm-14 minutes, termed advanced prf [a-prf]) and low-speed + time (1,300 rpm-8 minutes; a-prf+) were investigated.Each prf matrix was tested for growth factor release up to 10 days (eight donor samples) as well as biocompatibility and cellular activity.Results the low-speed concept (a-prf, a-prf+) demonstrated a significant increase in growth factor release of platelet-derived growth factor (pdgf), transforming growth factor (tgf)-β1, epidermal growth factor, and insulin-like growth factor, with a-prf+ being highest of all groups.Although all prf formulations were extremely biocompatible due to their autogenous sources, both a-prf and a-prf+ demonstrated significantly higher levels of human fibroblast migration and proliferation compared with l-prf.Furthermore, gingival fibroblasts cultured with a-prf+ demonstrated significantly higher messenger rna (m rna) levels of pdgf, tgf-β, and collagen1 at either 3 or 7 days.Conclusions the findings from the present study demonstrate modifications to centrifugation speed and time with the low-speed concept favor an increase in growth factor release from prf clots.This, in turn, may directly influence tissue regeneration by increasing fibroblast migration, proliferation, and collagen m rna levels.Future animal and clinical studies are now necessary.

Journal: Journal of periodontology (2017)
Publication types: Journal Article
Enhancement of microalgae growth using magnetic artificial cilia.

Microalgae have shown great potential as a source of biofuels, food, and other bioproducts.More recently, microfluidic devices have been employed in microalgae-related studies.However, at small fluid volumes, the options for controlling flow conditions are more limited and mixing becomes largely reliant on diffusion.In this study, we fabricated magnetic artificial cilia (mac) and implemented them in millimeter scale culture wells and conducted growth experiments with scenedesmus subspicatus while actuating the mac in a rotating magnetic field to create flow and mixing.In addition, surface of mac was made hydrophilic using plasma treatment and its effect on growth was compared with untreated, hydrophobic mac.The experiments showed that the growth was enhanced by ten and two times with hydrophobic and hydrophilic mac, respectively, compared with control groups which contain no mac.This technique can be used to investigate mixing and flow in small sample volumes, and the enhancement in growth can be beneficial for the throughput of screening studies.Moreover, the methods used for creating and controlling mac can be easily adopted in labs without microfabrication infrastructures, and they can be mastered by people with little prior experience in microfluidics.

Journal: Biotechnology and bioengineering (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Self-Assembly of Colloidal Nanocrystals into 3D Binary Mesocrystals.

Biominerals are unique materials found in many living organisms that often display outstanding functionalities attributed to their mesocrystalline structure.Mesocrystals are nanocrystal superstructures with mutual crystallographic alignment of the building units.One could thus imagine these optimized evolutionary systems as archetypes to fabricate advanced materials.The main advantage of such systems relies on their ability to combine the features of the nanocrystals with those of single crystalline microscopic structures, yielding assemblies with directional, enhanced, and potentially emergent properties.Moreover, fueled by the promises of multifunctional materials with unprecedented and tunable properties, the rational design of mesocrystals assembled from two distinct colloidal nanocrystal ensembles has become a recent focus of research.However, the combination of dissimilar nanocrystals into ordered binary superstructures is still a major scientific challenge due to the nature of the coassembly process.we focus this account on the growth of tridimensional (3d) binary mesocrystals and the understanding of the self-assembly of two colloidal nanocrystal ensembles with the ultimate goal to serve as a basis for more rational mesocrystal syntheses in the future.The formation of mesocrystals demands nanocrystals with defined surface faceting, the primary factor influencing their oriented self-assembly.Notably, such a process cannot be successfully afforded without functionalized nanocrystals with high and, in many cases, tunable colloidal stability.Besides, the nature and solvation degree of the surface ligand shell influences the effective shape of the nanocrystals and the kinetics of self-assembly.If the assembly is triggered by reducing the colloidal stability with nonsolvents, 3d single-component mesocrystals are often grown.Here, the different magnitude of the van der waals attraction forces between nanocrystals with differing compositions, dimensions, and morphologies generally favors the segregation and growth of single component mesocrystals.This phenomenon was illustrated during the successful preparation of 3d binary mesocrystals composed of iron oxide and platinum nanocubes.Although the building blocks possessed comparable sizes and were stabilized by similar ligands, the amount of the second component could only be arbitrarily tuned up to some extent, even when the assembly conditions were rationally optimized to achieve 3d binary mesocrystals.Only a small amount of it was effectively incorporated into the matrix of the initial mesocrystal.The 3d binary mesocrystal growth process demands a delicate control over the size, shape, and surface chemistry of the nanocrystals, the solvent nature, and the self-assembly process.Hence, the improvement of our ability to control the synthesis of 3d binary mesocrystalline materials is critical to exploit their potential toward technological applications in catalysis, energy storage, or structural materials.

Journal: Accounts of chemical research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Graves' disease, its treatments, and the risk of atrial fibrillation: A Korean population-based study.

Atrial fibrillation (af) is occasionally diagnosed in individuals with graves' disease.Definite treatments, including radioactive iodine therapy (rait) or surgery might lower the risk of af in the literature.However, no studies have compared the effects of anti-thyroid drugs (atds), rait, and surgery on the risk of af.Methods this retrospective cohort study included 94,060 newly diagnosed graves' disease patients and 470,300 controls from the korean national health insurance database.The incidence of af was evaluated in patients and controls.Patients were categorized based on treatment method into atd (95.6%), rait (3.5%), and surgery (0.9%) groups.In the atd group, the dose and duration of atds were calculated for each patient.In the rait and surgery groups, remission was defined as levothyroxine prescription.Results graves' disease patients had a 2.2-fold higher risk of developing af than controls.Regardless of demographic factors, the patient group had a consistently higher risk of af than controls, with the highest risk of af (hr, 5.49) in the younger patient group.The surgery group had a similar risk of af compared with controls, whereas the atd (hr, 2.23) and rait (hr, 2.00) groups had increased risks of af, even in patients reaching hypothyroid status after rait.Patients with higher dose or longer treatment duration of atds were at greater risk of af.Conclusion we observed differing risks of af according to methods of treatment for graves' disease, and that definite treatment can be an option for subjects needing sustained medical treatment considering the risk of af.

Journal: Frontiers in endocrinology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Source identification of exhaust and non-exhaust traffic emissions through the elemental carbon fractions and Positive Matrix Factorization method.

Our study implies the importance of exhaust and non-exhaust emissions in a highway road tunnel, which is crucial to assess their impacts on air quality, human health, climate and developing functional methods for controlling.The total suspended particulates (tsp) and road dust (rd) samples were collected by puf samplers and manually sweeping, respectively.Campaigns were performed in the summer and winter of 2014 in a highway road tunnel in bolu, turkey.Chemical analyses were presented to characterize the contents of organic carbon (oc) fractions (oc1,2,3,4), elemental carbon (ec) fractions (ec1,2,3,4,5,6), polycyclic aromatic hydrocarbons (pahs) and metals (al, ba, ca, cu, mg, mn, pb, sr, cr and fe) in the collected tsp and rd samples.Positive matrix factorization (pmf) and orthogonal (deming) regression analysis were applied to find out the exhaust and non-exhaust vehicle emissions of metal and carbonaceous species in the tunnel.The results showed that the identified source profiles included resuspended road dust (43%), non-exhaust emissions (37%), diesel exhaust emissions (13%), and gasoline exhaust emissions (7%).The relationship between emission markers of metal species and ec carbon fractions was supported by correlation studies.Among these ec fractions, ec4 and ec2 were the most abundant fractions in aerosol and rd samples, respectively and so they highly represented the diesel and non-exhaust emissions.Besides, the ec1 fraction was the indicator of gasoline-fueled emissions.Lower ec1 and higher soot-ec contribution obtained in tunnel aerosol (as) samples showed the dominance of diesel-fueled vehicles in the tunnel.The data represented herein would help to identify the characteristic of vehicle emissions.

Journal: Environmental research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Collective narrative practice with unaccompanied refugee minors: "The Tree of Life" as a response to hardship.

During the summer of 2016, in the midst of one of the biggest refugee crises in centuries, the author of this article joined the team from a shelter for unaccompanied refugee minors on samos, greece, in an effort to provide young boys seeking asylum in europe with an opportunity to engage in speaking about the difficulties they have encountered in life.The team used a collective narrative methodology called the "tree of life", originally developed by ncube-mlilo and denborough.In addition to traditional psychological treatments, collective narrative practice creates a secure foundation for addressing trauma, suffering, and hardship.This approach takes into consideration cultural differences and is easy to access for refugees with perceived stigma of traditional mental health services.The tree of life is a minimum of 8-hour workshop involving a strength-based narrative methodology, using the tree as a metaphor.This enables participants to share and develop enriching stories about their lives, which are rooted in their cultural and social histories.The workshop conducted on samos proved to be an effective way to invite young unaccompanied minors to speak about their difficulties in ways that were not retraumatizing, but instead made them stronger.

Journal: Clinical child psychology and psychiatry (2018)
Publication types: Journal Article
Copper(I) Catalyzed Decarboxylative Synthesis of Diareno[a,e]cyclooctatetraenes.

Diareno[a,e]cyclooctatetraenes find widespread applications as building blocks, ligands, and responsive cores in topologically switchable materials.However, current synthetic methods to these structures suffer from low yields or operational disadvantages.Here, we describe a practical three-step approach to diareno[a,e]cyclooctatetraenes using an efficient copper(i) catalyzed double decarboxylation as the key step.The sequence relies on cheap and abundant reagents, is readily performed on scale, and is amenable also to unsymmetrical derivatives that expand the utility of this intriguing class of structures.

Journal: The Journal of organic chemistry (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Oromandibular Dystonia - A Systematic Review.

Oromandibular dystonia (omd) is a clinical problem which is commonly encountered in the practice of movement disorders.Omd results from a variety of genetic and acquired etiologies and can occur as an isolated manifestation, or as part of an isolated generalized or a combined dystonia syndrome.There are only very few systematic reviews on this condition which often causes significant disability.We review here the etiology, clinical features, diagnostic approach and management of omd.

Journal: Annals of Indian Academy of Neurology (2022)
Publication types: Journal Article
Feedback from HTC Vive Sensors Results in Transient Performance Enhancements on a Juggling Task in Virtual Reality.

Virtual reality headsets, such as the htc vive, can be used to model objects, forces, and interactions between objects with high perceived realism and accuracy.Moreover, they can accurately track movements of the head and the hands.This combination makes it possible to provide subjects with precise quantitative feedback on their performance while they are learning a motor task.Juggling is a challenging motor task that requires precise coordination of both hands.Professional jugglers throw objects so that the arc peaks just above head height, and they time their throws so that the second ball is thrown when the first ball reaches its peak.Here, we examined whether it is possible to learn to juggle in virtual reality and whether the height and the timing of the throws can be improved by providing immediate feedback derived from the motion sensors.Almost all participants became better at juggling in the ~30 min session: the height and timing of their throws improved and they dropped fewer balls.Feedback on height, but not timing, improved performance, albeit only temporarily.

Journal: Sensors (Basel, Switzerland) (2021)
Publication types: Journal Article
Binocular mirror-symmetric microsaccadic sampling enablesDrosophilahyperacute 3D vision.

Significance to move efficiently, animals must continuously work out their x,y,z positions with respect to real-world objects, and many animals have a pair of eyes to achieve this.How photoreceptors actively sample the eyes' optical image disparity is not understood because this fundamental information-limiting step has not been investigated in vivo over the eyes' whole sampling matrix.This integrative multiscale study will advance our current understanding of stereopsis from static image disparity comparison to a morphodynamic active sampling theory.It shows how photomechanical photoreceptor microsaccades enable drosophilasuperresolution three-dimensional vision and proposes neural computations for accurately predicting these flies' depth-perception dynamics, limits, and visual behaviors.

Journal: Proceedings of the National Academy of Sciences of the United States of America (2022)
Publication types: Journal Article
Dental discoloration following Le Fort 1 osteotomy, a systematic review.

Introduction this study was conducted to review current knowledge concerning factor and how to proceed with dental discoloration after le fort 1 osteotomy (lf1o).Material & methods a systematic search of the literature was performed in pub med/medline and cochrane library until december 1, 2020 using the following key words: "dental discoloration and osteotomy", "dental discoloration and le fort", "dental discoloration and orthognathic", "dental discoloration and surgery", "tooth discoloration and osteotomy", "tooth discoloration and le fort", "tooth discoloration and orthognathic", "tooth discoloration and surgery".Results 705 studies were located by initial screening; 232 were duplicate, 468 did not meet the eligibility criteria, leaving 5 studies.The post-operative follow-up period of the included studies ranged from 6 months to 2 years.Conclusion the present revue found dental discoloration can occur after lf1o in 3.56% of the cases.The follow-up before treatment should be around one years.If the discoloration persisted and pulpal sensibility test is negative, the tooth should be treated.If the pulpal sensibility test is positive, follow-up should be carry on.

Journal: Journal of stomatology, oral and maxillofacial surgery (2022)
Publication types: Journal Article;Systematic Review
Transitions Between Frailty States and Its Predictors in a Cohort of Community-Dwelling Spaniards.

S study the frequency and determinants of frailty transitions in a community-dwelling older population.Design population-based prospective longitudinal study [the toledo study of healthy ageing (tsha)].Setting and participants 1748 community-dwelling individuals aged >65 years living in toledo, a spanish province.Methods frailty was measured with the fried phenotype.Logistic models were used to assess the associations of sociodemographic, clinical, life-habits, functional, physical performance, and analytical variables with frailty transitions (losing robustness, transitioning from prefrailty to robustness, and from prefrailty to frailty) over a median of 5.2 years.Results mean age on enrolment was 75 years, and 55.8% were females.At baseline, 10.3% were frail and 43.1% prefrail.At follow-up, 35.8% of the frail individuals recovered to a prefrail and 15.1% to a robust state.In addition, 43.7% of the prefrail participants became robust, but 14.5% developed frailty.Of those robust at baseline, 32.9% became prefrail and 4.2% frail.In multivariate logistic models, chair-stands had a predictive role in all transitions studied: linearly in keeping robustness and with a floor effect (5 stands) in transitions from prefrailty to robustness and (inversely) from prefrailty to frailty.More depressive symptoms were associated with unfavorable transitions.Not declaring the amount of alcohol drunk and low grip strength were associated with loss of robustness.Hearing and cognitive impairment, low physical activity and smoking with transitioning from prefrailty to frailty.Autonomy for instrumental activities of daily living and uricemia were associated with transitions between robustness and prefrailty in both directions.Increasing body mass index in the range of moderate to severe obesity hampered regaining robustness.Conclusions and implications spontaneous improvement of frailty measured with the fried phenotype is frequent, mainly to prefrailty.Most of the variables associated with transitions are modifiable and suggest research topics and interventions to reduce frailty in clinical and social care settings.

Journal: Journal of the American Medical Directors Association (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Preventing Retinal Detachment: The Encircling Laser Retinopexy Technique.

Encircling (360 degree) retinal detachment prophylaxis using indirect ophthalmoscope laser delivery recently achieved strong proof of safety and effectiveness by preventing the development of peripheral retinal tears and detachments in the eyes of patients with stickler syndrome (syndromic eyes).Untreated, stickler syndrome patients have a 65% lifetime risk of retinal detachment (half by age 20, 80% bilateral).This report describes an optimal technique of encircling laser retinopexy to also prevent the more common retinal detachments seen in aging (non-syndromic) eyes that share with stickler syndrome the common pathogenesis of peripheral retinal tears caused by vitreous traction.

Journal: Clinical ophthalmology (Auckland, N.Z.) (2023)
Publication types: Journal Article
Biotechnological Approaches for Genetic Improvement of Lemon (Citrus limon(L.) Burm. f.) againstMal SeccoDisease.

Among citrusspecies, lemon is one of the most susceptible tomal seccodisease, a tracheomycosis caused by the mitosporic fungus plenodomus tracheiphilus,which induces chlorosis followed by leaf drop and progressive desiccation of twigs and branches.Severe infection can cause the death of the plant.Since no effective control strategies are available to efficiently control the pathogen spread, host tolerance is the most desirable goal in the struggle againstmal seccodisease.To date, both traditional breeding programs and biotechnological techniques were not efficient in developing novel varieties coupling tolerance tomal seccowith optimal fruit quality.Furthermore, the genetic basis of host resistance has not been fully deciphered yet, hampering the set-up of marker-assisted selection (mas) schemes.This paper provides an overview of the biotechnological approaches adopted so far for the selection ofmal seccotolerant lemon varieties and emphasizes the promising contribution of marker-trait association analysis techniques for both unraveling the genetic determinism of the resistance tomal seccoand detecting molecular markers that can be readily used for mas.Such an approach has already proved its efficiency in several crops and could represent a valuable tool to select novel lemon varieties coupling superior fruit quality traits and resistance tomal secco.

Journal: Plants (Basel, Switzerland) (2021)
Publication types: Journal Article;Review
Structural changes of ethanolamine plasmalogen during intestinal absorption.

Considerable attention has been paid to the absorption mechanisms of plasmalogen (pls) because its intake has been expected to have preventive effects on brain-related diseases.Possible structural changes of pls during absorption (i.e., preferential arachidonic acid re-esterification at the sn-2 position and base conversion of ethanolamine pls (pe-pls) into choline pls (pc-pls)) have previously been proposed.Since the physiological functions of pls differ according to its structure, further elucidation of such structural changes during absorption is important to understand how pls exerts its physiological effects in vivo.Hence, the absorption mechanism of pls was investigated using the lymph-cannulation method and the everted jejunal sac model, with a focus on pls molecular species.In the lymph-cannulation method, relatively high amounts of pe-pls 18:0/20:4 and pc-pls 18:0/20:4 were detected from the lymph even though these species were minor in the administered emulsion.Moreover, a significant increase of pe-pls 18:0/20:4 and pc-pls 18:0/20:4 in the intestinal mucosa was also confirmed by the everted jejunal sac model.Therefore, structural changes of pe-pls in the intestinal mucosa were strongly suggested.The results of this study may provide an understanding of the relationship between intestinal absorption of pls and exertion of its physiological functions in vivo.

Journal: Food & function (2020)
Publication types: Journal Article