syedzayyan/paper_mill_benchmark huggingface dataset:
Trabecular Bone Score as a Reliable Measure of Lumbar Spine Bone Microarchitecture in Acromegalic Patients.

Although gh and igf-1 excess has a controversial impact on bone mineral density (bmd), acromegalic patients display variable degrees of bone structure impairment.In this study, we aim to investigate the usefulness of trabecular bone score (tbs), compared to bmd, in identifying acromegalic patients with impaired lumbar spine trabecular microarchitecture.Forty-four acromegalic patients were investigated for disease control, metabolic and gonadal status, bone metabolism parameters, and the presence of vertebral fractures (vfs).Patients and matched healthy controls underwent bmd and tbs examination.Mean tbs values were lower in patients than in controls (p < 0.001), without significant differences in mean lumbar and femoral bmd.Tbs values were significantly higher in controlled patients compared to the uncontrolled ones (p = 0.012).No significant differences were found in bone markers with respect to disease control.Mean tbs or lumbar bmd did not significantly differ in patients with or without vfs (prevalence 11.4%).Tbs and bmd levels were lower in hypogonadal patients compared to the eugonadal ones (p = 0.030 and p < 0.001, respectively).In conclusion, tbs values are significantly lower in patients than in controls, confirming the presence of impaired lumbar spine trabecular bone in acromegaly.Both uncontrolled disease and hypogonadism contribute to tbs deterioration in acromegaly.

Journal: Journal of clinical medicine (2022)
Publication types: Journal Article
Burkholderia ambifariaXN08: A plant growth-promoting endophytic bacterium with biocontrol potential against sharp eyespot in wheat.

Plant growth-promoting bacteria (pgpb) have been considered promising biological agents to increase crop yields for years.However, the successful application of pgpb for biocontrol of sharp eyespot in wheat has been limited, partly by the lack of knowledge of the ecological/environmental factors affecting the colonization, prevalence, and activity of beneficial bacteria on the crop.In this study, an endophytic bacterium xn08 with antagonistic activity against rhizoctonia cerealis(wheat sharp eyespot pathogenic fungus), isolated from healthy wheat plants, was identified as burkholderia ambifariaaccording to the sequence analysis of 16s r rna.The antibiotic synthesis gene amplification and ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (uplc-qtof-ms) analyses were used to characterize the secondary metabolites.The results showed that the known powerful antifungal compound named pyrrolnitrin was produced by the strain xn08.In addition,b.Ambifaria xn08 also showed the capacity for phosphate solubilization, indole-3-acetic acid (iaa), protease, and siderophore productionin vitro.In the pot experiments, a derivate strain carrying the green fluorescent protein (gfp) gene was used to observe its colonization in wheat plants.The results showed that gfp-tagged b.Ambifariacould colonize wheat tissues effectively.This significant colonization was accompanied by an enhancement of wheat plants' growth and an induction of immune resistance for wheat seedlings, which was revealed by the higher activities of polyphenol oxidase (ppo), peroxidase (pod), and phenylalanine ammonia-lyase (pal).As far as we know, this is the first report describing the colonization traits of b.Ambifariain wheat plants.In addition, our results indicated that b.Ambifaria xn08 might serve as a new effective biocontrol agent against wheat sharp eyespot disease caused by r.Cerealis.

Journal: Frontiers in microbiology (2022)
Publication types: Journal Article
Worse outcomes of ACS patients without versus with traditional cardiovascular risk factors.

Introduction up to 20% of patients presenting with acute coronary syndrome (acs) have no traditional cardiovascular risk-factors (rfs).Data regarding the determinants, management, and outcomes of these patients are scarce.Objectives to evaluate the management, outcomes, and time-dependent changes of acs patients without rfs.Methods evaluation of clinical characteristics, management strategies, and outcomes as well as time-dependent changes [by 3 time periods: early (2000-2006), mid (2008-2013), and late (2016-2018)] of acs patients without rfs (diabetes mellitus, hypertension, dyslipidemia, family history of ischemic heart disease, and smoking) or known coronary artery disease, enrolled in the biennial acs israeli surveys (acsis) between 2000 and 2018.We compared acs patients without rfs (no-rf group) to those with ≥1 rfs (rf group).Results overall, 554/9,683 (5.7%) eligible acs patients did not have any rfs [median age 63 (iqr 52-76) years, 25% females].The no-rf group were older, with lower body mass index and prevalence of other cardiovascular comorbidity and chronic kidney disease compared with the rf group.The in-hospital percutaneous coronary intervention rates were lower among the no-rf vs.The rf group (55% vs.66%, respectively p<0.001).Furthermore, lower rate of guideline-recommended medical therapy upon discharge was prescribed in the no-rf group.The rate of in-hospital complications was greater in the no-rf vs.Rf group (31.6% vs.26.1%, respectively p=0.005).The rates of 30-day major adverse cardiovascular events (mace; 17.6% vs.12.8%, respectively, p=0.002) and of 30-day and 1-year all-cause mortality (8.4% vs.4.2%, p<0.001 and 11.4% vs.7.7%, p=0.003 respectively) were higher among patients with no-rf vs.Rf.Following propensity score matching 30-day mace, 30-day and 1-year mortality risk remained higher in the no-rf group.The rate of 30-day mace decreased between the early and the late study period in the no-rf group (21.5% vs.10.5%, p=0.003, respectively).Conclusions acs patients without traditional cardiovascular risk-factors comprise a unique group with reduced prevalence of comorbidities yet significantly worse outcomes.Additional research to identify unique risk-factors and targets for interventions to improve outcomes of this group of patients is warranted.

Journal: Journal of cardiology (2022)
Publication types: Journal Article
Temporal changes in morality attributed to heat extremes for 57 cities in Northeast Asia.

Recent studies have reported that heat-related mortality decreased by adaptation during decades.However, since the frequency of extreme heat events is increasing, it is difficult to conclude with certainty that the heat mortality burden is decreasing.To examine temporal changes in mortality attributed to heat extremes in northeast asia, we collected temperature and mortality data covering the years 1972-2012 from 57 cities of 3 countries (taiwan, korea, and japan) in northeast asia.Poisson regression curves were fitted to the data from each city.The temporal changes in heat-mortality association were estimated with a time-varying distributed lag non-linear model.Heat extremes were defined as temperatures greater than the 97.5th percentiles of city-specific average temperatures.Attributable deaths were calculated considering temporal variations in exposure and relative risk.The estimates were then pooled through meta-analysis.The results show that the mortality risk on extreme heat days declined during the study period in all countries.However, as summer temperatures in japan have shown more heat extremes over time, the mortality risk attributed to heat increased during 2003-2012 (0.32%) compared with 1972-1981 (0.19%).Thus, to assess the total health burden due to heat extremes related to climate change, public health strategies should focus on the temporal variation in heat-mortality association as well as changes in the distribution of heat extremes overtime.

Journal: The Science of the total environment (2018)
Publication types: Journal Article
A new dawn beyond lysine ubiquitination.

The ubiquitin system has become synonymous with the modification of lysine residues.However, the substrate scope and diversity of the conjugation machinery have been underappreciated, bringing us to an epoch in ubiquitin system research.The striking discoveries of metazoan enzymes dedicated toward serine and threonine ubiquitination have revealed the important role of nonlysine ubiquitination in endoplasmic reticulum-associated degradation, immune signaling and neuronal processes, while reports of nonproteinaceous substrates have extended ubiquitination beyond the proteome.Bacterial effectors that bypass the canonical ubiquitination machinery and form unprecedented linkage chemistry further redefine long-standing dogma.While chemical biology approaches have advanced our understanding of the canonical ubiquitin system, further study of noncanonical ubiquitination has been hampered by a lack of suitable tools.This perspective aims to consolidate and contextualize recent discoveries and to propose potential applications of chemical biology, which will be instrumental in unraveling this new frontier of ubiquitin research.

Journal: Nature chemical biology (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't
The Frailty Matters Project.

Preventing and managing frailty is a new area for many community practitioners; yet, frailty specific-education remains limited.This collaborative project aimed to understand and enhance the knowledge, confidence and capability of community nurses to manage frailty in a community setting.A person-centred coaching and educational programme was co-developed with community nurse participants to strengthen their leadership role in managing frailty within interprofessional teams.The "frailty house" was created as an educational framework for the elements that participants described as important in order to live well with frailty, built on a foundation of leadership and coaching skills.Thematic content analysis of the data revealed the added value of combining technical knowledge and relational skills-building with peer support and coaching.All recognised the challenge of caring for people living with frailty at a difficult time and acknowledged that they would benefit hugely from further knowledge and skill development in this field.

Journal: British journal of community nursing (2023)
Publication types: Journal Article
Reply to: Beyond Money: Conscientious Objection in Medicine as a Conflict of Interests.

Giubilini and savulescu in their recent journal of bioethical inquiry symposium article presented an account of conscientious objection that argues for its recognition as a non-financial conflict of interest.In this short commentary, i highlight some problems with their account.First, i discuss their solicitor analogy.Second, i discuss some problems surrounding their objectivity claim about standards of medical care.Next, i discuss some issues arising from consistently applying their approach.Finally, i highlight that conscientious objection should be viewed not as a conflict of interest but as something that society has an interest in preserving.I conclude by arguing that clinicians who have a conscientious objection can be treated in the same way as those who decide to subspecialize and do not need to give up work in their specialty.While giubilini and savulescu present an interesting argument about conscientious objection, theirs is not a compelling view.Indeed, the way we approach conscientious objection has more to teach us about conflicts of interest than the other way around.

Journal: Journal of bioethical inquiry (2021)
Publication types: Journal Article;Comment
Association between Prestored Smartphone Monitored Physical Activity and the Risk of HPV Infection and Cervical Cancer.

This study was to determine the prevalence of hpv in non-vaccinated women from east china, and the association between prestored smartphone monitored physical activity and the risk of human papillomaviruses (hpv) infection and cervical cancer.Methods we retrospectively reviewed medical records of unvaccinated women received first-time cervical hpv screening in the affiliated cancer hospital of university of chinese academy of sciences between march 2018 and december 2019.Hpv genotyping was examined by the geno array.Physical activity defined by any movements at speeds of 0.5-2 m/s was obtained from smartphones.We collected prestored physical activity data for 6 months prior to the hpv screening.Logistic regression models were applied to determine the association between physical activity and the risk of hpv infection and cervical cancer.Results a total of 11,730 women were initially included.Women with cervical cancer had significantly higher prevalence of infection with any high-risk (hr) hpv, or with individual hpv16, 18, 31, 33, 45, 52 and 58.Among them, 896 controls and 289 cervical cancer women had information of smartphone monitored physical activity.Multivariate logistic regression analysis showed that more daily physical activity time (or distance) was a protective factor for infection with any hr hpv, or infection with hpv16, but not other individual hpvs.Increased age, less physical activity time (or distance), and infection with any hr hpv (16, 18, 31, 52 and 58) were associated with a significantly increased risk of cervical cancer.In contrast, obesity was not associated with risk of hpv infection and cervical cancer.Conclusion the high prevalence of hpv infection in unvaccinated women highlights the importance of prevention.More daily physical activity time (or distance) may help to reduce the risk of hpv infection and cervical cancer.Smartphone monitoring is an effective tool for recording physical activity..

Journal: Asian Pacific journal of cancer prevention : APJCP (2022)
Publication types: Journal Article
Biosynthetic cellulose compared to porcine xenograft in the treatment of partial-thickness burns: A randomised clinical trial.

The aim was to compare two dressing treatments for partial-thickness burns: biosynthetic cellulose dressing (bs c) (epiprotect® s2medical ab, linköping, sweden) and porcine xenograft (ez derm®, mölnlycke health care, gothenburg, sweden).Methods twenty-four adults with partial-thickness burns were included in this randomized clinical trial conducted at the burn centers in linköping and uppsala, sweden between june 2016 and november 2018.Time to healing was the primary outcome.Secondary outcomes were wound infection, pain, impact on everyday life, length of hospital stay, cost, and burn scar outcome (evaluated with posas).Results we found no significant differences between the two dressing groups regarding time to healing, wound infection, pain, impact on everyday life, duration of hospital stay, cost, or burn scar outcome at the first follow up.Burn scar outcome at the 12-month follow up showed that the porcine xenograft group patients scored their scars higher on the posas items thickness (p = 0.048) and relief (p = 0.050).This difference was, however, not confirmed by the observer.Conclusions the results showed the dressings performed similarly when used in adults with burns evaluated as partial thickness.

Journal: Burns : journal of the International Society for Burn Injuries (2022)
Publication types: Journal Article;Randomized Controlled Trial
Active control of dielectric nanoparticle optical resonance through electrical charging.

A novel method for active control of resonance position of dielectric nanoparticles by increasing the excess charges carried by the nanoparticles is proposed in this paper.We show that as the excess charges carried by the particle increase, the oscillation frequency of excess charges will gradually increase, when it is equal to the incident frequency, resonance occurs due to resonant excitation of the excess charges.What is more, the formula of charges carried by an individual particle required to excite the resonance at any wavelength position is proposed.The resonance position can be directly controlled by means of particle charging, and the enhancement of resonance intensity is more obvious.This work has opened new avenues for the active control of plasmon resonances, which shows great promise for realizing tunable optical properties of dielectric nanoparticles.

Journal: Scientific reports (2022)
Publication types: Journal Article
Growth influence of juvenile golden trout (Oncorhynchus mykiss) in different osmotic conditions: implications for tissue histology, biochemical indicators, and genes transcription involved in GH/IGF system.

The objectives of this study were to evaluate the effects of different salinity levels on tissue histology, blood biochemistry, and genes transcription of the gh/igf system in juvenile golden trout (oncorhynchus mykiss).Five experimental salinity levels (0, 8, 16, 24, and 32‰) were selected to domesticate juvenile o.Mykiss for 7 days.Histological characteristics changed with salinity, including higher ionocites area and epithelium thickness in gills, narrow lumen of collecting tubules in kidneys, and high numbers of goblet cells in the intestines.Similarly, increments in slits, degenerate hepatocytes, and individualization of hepatocytes have been shown in fish reared in the 32‰ salinity group.The lowest triglyceride (tg) and the highest level of total protein (tp) were detected in fish reared at the 32‰ group.The genes transcription of the gh/igf system altered in response to the increase of salinity.The present results add to the understanding of the physiological responses of o.Mykiss on salinity stress and would be helpful in formulating strategies to optimize the aquaculture of this species in environments with fluctuating patterns of salinity.

Journal: Fish physiology and biochemistry (2021)
Publication types: Journal Article
Integrative analyses of genes related to liver ischemia reperfusion injury.

Liver ischemia reperfusion injury (liri) is not only a common injury during liver transplantation and major hepatic surgery, but also one of the primary factors that affect the outcome of postoperative diseases.However, there are still no reliable ways to tackle the problem.Our study aimed to find some characteristic genes associated with immune infiltration that affect liri, which can provide some insights for future research in the future.Therefore, it is essential for the treatment of liri, the elucidation of the mechanisms of liri, and exploring the potential biomarkers.Efficient microarray and bioinformatics analyses can promote the understanding of the molecular mechanisms of disease occurrence and development.Method data from gse151648 were downloaded from geo data sets, and we performed a comprehensive analysis of the differential expression, biological functions and interactions of liri-associated genes.Then we performed gene ontology (go) analysis and kyotoencydlopedia of genes and genomes (kegg) enrichment analysis of degs.At last, we performed a protein-protein interaction network to screen out hub genes.Results a total of 161 differentially expressed genes (degs) were identified.Go analysis results revealed that the changes in the modules were mostly enriched in the neutrophil degranulation, neutrophil activation involved in immune response, and neutrophil mediated immunity.Kegg enrichment analysis of degs demonstrated that liri mainly involved the cytokine-cytokine receptor interaction.Our data indicated that macrophages and neutrophils are closely related to liri.9 hub genes were screened out in the protein-protein interaction network.Conclusions in summary, our data indicated that neutrophil degranulation, neutrophil activation involved in immune response, neutrophil mediated immunity and cytokine-cytokine receptor interaction may play a key role in liri, hrh1, lrp2, p2ry6, pkd1l1, slc8a3 and tnfrsf8, which were identified as potential biomarkers in the occurrence and development of liri.However, further studies are needed to validate these findings and explore the molecular mechanism of these biomarkers in liri.

Journal: Hereditas (2022)
Publication types: Journal Article
Effect of Preoperative Anxiety on Postoperative Pain after Craniotomy.

Pain following craniotomy is challenging.Preoperative anxiety can be one of the controllable factors for prevention of post-craniotomy pain.The main objective of this prospective observational study is to determine this relationship in patients undergoing scheduled craniotomy from february to june 2021.After excluding patients with mini-mental state examination (mmse) ≤ 24 points, we administered a preoperative state trait anxiety inventory (stai) questionnaire.We recorded the patient's analgesic assessment using the numerical rating score (nrs) at 1, 8, 24, and 48 h after surgery.A total of 73 patients were included in the study.Twelve others were excluded due to a mmse ≤ 24 points.The main predictors for nrs postoperatively at 1, 8, 24, and 48 h were stai a/e score, male gender, youth, and depression.We identified a cut-off point of 24.5 in stai a/e for predicting a nrs > 3 (sensitivity 82% and specificity 65%) at 24 h postoperative and a cut-off of 31.5 in stai a/r (sensitivity 64% and specificity 77%).In conclusion, preoperative stai scores could be a useful tool for predicting which patient will experience at least moderate pain after craniotomy.The identification of these patients may allow us to highlight psychological preparation and adjuvant analgesia.

Journal: Journal of clinical medicine (2022)
Publication types: Journal Article
Understanding Factors Associated with Suicidality Among Transgender and Gender-Diverse Identified Youth.

Individuals who identify as transgender and gender-diverse (tgd) experience heightened rates of mental health challenges compared with cisgender people (including both heterosexual and lesbian, gay, and bisexual individuals).Furthermore, adolescence has been identified as a critical period for intervention as the majority of suicide attempts occur during this time period.However, no study to date has synthesized prior literature to understand the correlates of suicidal behavior among tgd youth, which is an essential step needed to inform intervention development and reduce suicidal behaviors in this community.methods:three databases were searched following the preferred reporting items for systematic reviews and meta-analyses method to assess eligibility for study inclusion.Five studies met full inclusion criteria.results:analyses revealed a consistent relationship across studies between suicidal behaviors and symptoms of depression, gender-based victimization, and bullying, and lack of parental support.conclusions:consistent with minority stress theory, this systematic review demonstrates that identification as tgd is associated with increased environmental stressors, highlighting the importance of considering both individual and contextual factors in the development of mental health interventions for tgd youth.Given the significance of findings related to the association between both depression and gender-based victimization and suicidal behavior, it is critical to advocate for the destigmatization of noncisgender identities through policy-level change.

Journal: LGBT health (2021)
Publication types: Journal Article;Review