syedzayyan/paper_mill_benchmark huggingface dataset:
Perioperative gabapentinoid use lowers short-term opioid consumption following lower limb arthroplasty: Systematic review and meta-analysis.

The management of post-operative pain and high levels of acute and chronic opioid use following total knee arthroplasty (tka) and total hip arthroplasty (tha) remain challenges to the perioperative team.We performed a system-atic review and meta-analysis to determine the opioid sparing effects, analgesic effects, and safety profile of perioperative gabapentinoid usage in lower limb arthroplasty.Methods we searched multiple databases from inception until may 2019 and included randomized controlled trials (rct) on perioperative gabapentinoids in lower limb arthroplasty.The primary outcome was cumulative opioid con-sumption (oral morphine equivalents) at 24 and 48 hours, and the secondary outcomes were pain scores, time to hospi-tal discharge, and adverse events including nausea, vomiting, pruritus, and sedation.Methodological quality was as-sessed using the cochrane tool.The grading of recommendations assessment, development, and evaluation method-ology for the certainty of evidence was also used.Results we included 19 rct involving 2,455 patients undergoing lower limb arthroplasty.The overall methodological quality of included studies was good.Gabapentinoid use was associated with a significant reduction in opioid consump-tion at 24 hour (mean difference (md) 22.81 mg [95 percent confidence interval (ci) 13.64-31.98]) and 48 hour (md 44.03 mg [95 percent ci 16.92-71.14]).We found no meaningful difference in pain scores at rest between gabapenti-noid and placebo groups at 24 or 48 hours.Gabapentinoid use reduced the risk of post-operative nausea (risk ratio (rr) 0.69 [95 percent ci 0.57-0.82]), vomiting (rr 0.65 [95 percent ci 0.47-0.91]), and pruritus (rr 0.60 [0.37-0.98]), but not sedation (rr 1.25 [0.76-2.06]).There was no effect on time to discharge from hospital (md-0.05 days [95 per-cent ci -0.31 to 0.20].Conclusions the addition of gabapentinoids to perioperative multimodal analgesia decreases opioid consumption fol-lowing lower limb arthroplasty, while also lowering rates of nausea, vomiting, and pruritus.Further study is required to evaluate the effect of gabapentinoid use on long-term opioid use and dependence.

Journal: Journal of opioid management (2021)
Publication types: Journal Article;Meta-Analysis;Systematic Review
Design and Synthesis of Fluorescent 1,3-Diaryl-β-carbolines and 1,3-Diaryl-3,4-dihydro-β-carbolines.

The 1,3-diaryl-β-carboline derivatives, including 3,4-dihydro variants, were synthesized via a multiple-step approach.These compounds possess rigid and twisted configurations, which are expected to exhibit unique optical properties.The absorption and fluorescence properties of the newly synthesized compounds were investigated.These synthetic 1,3-diaryl-β-carbolines displayed strong emission in the range of 387-409 nm and exhibited absolute photoluminescence quantum yields of up to 74%.Density functional theory calculations were performed to better elucidate the geometric, electronic, and optical properties of these novel 1,3-diaryl-β-carbolines.

Journal: ACS omega (2021)
Publication types: Journal Article
Use of Telemedicine to Improve Neonatal Resuscitation.

Most newborn infants do well at birth; however, some require immediate attention by a team with advanced resuscitation skills.Providers at rural or community hospitals do not have as much opportunity for practice of their resuscitation skills as providers at larger centers and are, therefore, often unable to provide the high level of care needed in an emergency.Education through telemedicine can bring additional training opportunities to these rural sites in a low-resource model in order to better prepare them for advanced neonatal resuscitation.Telemedicine also offers the opportunity to immediately bring a more experienced team to newborns to provide support or even lead the resuscitation.Telemedicine can also be used to train and assist in the performance of emergent procedures occasionally required during a neonatal resuscitation including airway management, needle thoracentesis, and umbilical line placement.Telemedicine can provide unique opportunities to significantly increase the quality of neonatal resuscitation and stabilization in rural or community hospitals.

Journal: Children (Basel, Switzerland) (2019)
Publication types: Journal Article;Review
Hormone-mediated foraging strategies in an uncertain environment: Insights into the at-sea behavior of a marine predator.

Hormones are extensively known to be physiological mediators of energy mobilization and allow animals to adjust behavioral performance in response to their environment, especially within a foraging context.few studies, however, have narrowed focus toward the consistency of hormonal patterns and their impact on individual foraging behavior.Describing these relationships can further our understanding of how individuals cope with heterogeneous environments and exploit different ecological niches.to address this, we measured between- and within-individual variation of basal cortisol (cort), thyroid hormone t3, and testosterone (test) levels in wild adult female galápagos sea lions (zalophus wollebaeki) and analyzed how these hormones may be associated with foraging strategies.In this marine predator, females exhibit one of three spatially and temporally distinct foraging patterns (i.e., "benthic," "pelagic," and "night" divers) within diverse habitat types.night divers differentiated from other strategies by having lower t3 levels.Considering metabolic costs, night divers may represent an energetically conservative strategy with shorter dive durations, depths, and descent rates to exploit prey which migrate up the water column based on vertical diel patterns.intriguingly, cort and test levels were highest in benthic divers, a strategy characterized by congregating around limited, shallow seafloors to specialize on confined yet reliable prey.This pattern may reflect hormone-mediated behavioral responses to specific risks in these habitats, such as high competition with conspecifics, prey predictability, or greater risks of predation.overall, our study highlights the collective effects of hormonal and ecological variation on marine foraging.In doing so, we provide insights into how mechanistic constraints and environmental pressures may facilitate individual specialization in adaptive behavior in wild populations.

Journal: Ecology and evolution (2021)
Publication types: Journal Article
Surgery for colorectal cancer in elderly patients: how can we improve outcome?

Patients over 70 years of age are characterised by diminished long-term survival rates following resection of colorectal cancer (crc) compared to younger patients.The aim of this study was to clarify whether reduced survival is a result of malignancy, comorbidities or the treatment received.Methods all patients with crc, who were admitted to our institution over a period of 10 years, were selected from a prospectively maintained database.Disease-specific, disease-free and overall survival rates were calculated dependent on variables considered potentially relevant for the patients' prognosis.Results 915 patients were included in the study.Observed 5- and 10-year survival rates for the whole group were 48 ± 2% and 40 ± 2%, respectively, but 10-year survival rates dropped to 14 ± 4% for patients aged 80 and older.Resection of the primary tumour was attempted in all cases independent of age.Emergency admission, charlson index ≥2, ecog ≥2, old age, second malignancies, distant metastases, high grading and non-resective surgery were identified as independent prognostic parameters associated with decreased overall survival.In contrast, disease-specific and disease-free survival rates for patients after elective radical resection in uicc-stage i-iii did not show significant differences related to age.Tumour site, uicc-stage and resection status were independent statistically significant predictors of disease-specific survival.Conclusions similar disease-specific survival rates in all age groups speak in favour of tumour resection in curative intent even in old patients.Better outcome may be achieved, if regular screening for colorectal cancer is considered even in the elderly to avoid late presentation requiring emergency surgery.

Journal: Journal of cancer research and clinical oncology (2017)
Publication types: Journal Article
Harnessing Intronic microRNA Structures to Improve Tolerance and Expression of shRNAs in Animal Cells.

Exogenous rna polymerase iii (pol iii) promoters are commonly used to express short hairpin rna (sh rna).Previous studies have indicated that expression of sh rnas using standard pol iii promoters can cause toxicity in vivo due to saturation of the native mi rna pathway.A potential way of mitigating sh rna-associated toxicity is by utilising native mi rna processing enzymes to attain tolerable sh rna expression levels.Here, we examined parallel processing of exogenous sh rnas by harnessing the natural mi rna processing enzymes and positioning a sh rna adjacent to micro rna107 (mi r107), located in the intron 5 of the pantothenate kinase 1 (pank1) gene.We developed a vector encoding the pank1 intron containing mi r107 and examined the expression of a single sh rna or multiple sh rnas.Using q rt-pcr analysis and luciferase assay-based knockdown assay, we confirmed that mi r30-structured sh rnas have resulted in the highest expression and subsequent transcript knockdown.Next, we injected hamburger and hamilton stage 14-15 chicken embryos with a vector encoding multiple sh rnas and confirmed that the parallel processing was not toxic.Taken together, this data provides a novel strategy to harness the native mi rna processing pathways for sh rna expression.This enables new opportunities for rnai based applications in animal species such as chickens.

Journal: Methods and protocols (2022)
Publication types: Journal Article
Effect of acupoint catgut embedding in chronic fatigue syndrome patients: A protocol for systematic review and meta-analysis.

Chronic fatigue syndrome (cfs) is a relatively complex and disabling illness with a substantial economic burden and functional impairment.Until now, many cfs patients lack appropriate healthcare.Acupoint catgut embedding is an effective and emerging alternative therapy for cfe.With this research, we endeavor to investigate the effect and safety of ace for cfs.Methods eight databases will be searched from inception to december 2020: pub med, embase, the cochrane library, web of science, china national knowledge infrastructure, chinese biomedical literature database, chong-qing vip database, and wan-fang database.We regard studies as eligible for inclusion if they were rcts done in cfs patients, compare acupoint catgut embedding to another treatment strategy, and report fatigue changes at the end of the intervention period.Two independent reviewers complete the study selection, data extraction, and the risk of bias assessment.We assess pooled data using a random-effects model through revman software (v.5.3) and stata (version 15.0).Ethics and dissemination ethics approval is not required because the individual patient data will not be involved, with no privacy concerns.This systematic review and meta-analysis will provide a reference for cfs patients and clinicians on the non-drug interventions.We will publish and disseminate the results of this review in a peer-reviewed journal or relevant conference.Osf registration number (

Journal: Medicine (2021)
Publication types: Journal Article
Can a pandemic make people more socially conservative? Political ideology, gender roles, and the case of COVID-19.

The first months of 2020 rapidly threw people into a period of societal turmoil and pathogen threat with the covid-19 pandemic.By promoting epistemic and existential motivational processes and activating people's behavioral immune systems, this pandemic may have changed social and political attitudes.The current research specifically asked the following question: as covid-19 became pronounced in the united states during the pandemic's emergence, did people living there become more socially conservative?We present a repeated-measures study (n= 695) that assessed political ideology, gender role conformity, and gender stereotypes among u.s.Adults before (january 25-26, 2020) versus during (march 19-april 2, 2020) the pandemic.During the pandemic, participants reported conforming more strongly to traditional gender roles and believing more strongly in traditional gender stereotypes than they did before the pandemic.Political ideology remained constant over time.These findings suggest that a pandemic may promote the preference for traditional gender roles.

Journal: Journal of applied social psychology (2021)
Publication types: Journal Article
A Nanovessel-Catalyzed Three-Component Aza-Darzens Reaction.

It has been previously demonstrated that nanovessels can be highly competent catalysts providing high rate accelerations and unique selectivity to the organic transformations which they mediate.However, for supramolecular assemblies to be considered a standard reagent in organic synthesis they must first demonstrate the ability to catalyze increasingly complex transformations.Herein, we report a three-component aza-darzens reaction that generates n-phenylaziridines, catalyzed by a supramolecular host, that provides the stereoisomer opposite to the one generated in bulk solution (transvscis).This transformation constitutes a rare catalytic three-component coupling within a supramolecular assembly, providing a supramolecular solution to a synthetically challenging transformation.

Journal: Journal of the American Chemical Society (2020)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, U.S. Gov't, Non-P.H.S.
Exploring the most important factors related to self-perceived health among older men in Sweden: a cross-sectional study using machine learning.

To evaluate which factors are the most strongly related to self-perceived health among older men and describe the shape of the association between the related factors and self-perceived health using machine learning.Design and setting this is a cross-sectional study within the population-based vascular and chronic obstructive lung disease study (vascol) conducted in southern sweden in 2019.Participants a total of 475 older men aged 73 years from the vascol dataset.Measures self-perceived health was measured using the first item of the short form 12.An extreme gradient-boosting model was trained to classify self-perceived health as better (rated:excellentorvery good) or worse (rated:fairorpoor) using self-reported data on 19 prevalent physician-diagnosedhealth conditions, intensity of 9symptomsand 9demographic and lifestyle factors.Importance of factors was measured in shapley additive ex planations absolute mean and higher scores correspond to greater importance.Results the most important factors for classifying self-perceived health were: pain (0.629), sleep quality (0.595), breathlessness (0.549), fatigue (0.542) and depression (0.526).health conditionsranked well belowsymptomsandlifestyle variables.Low levels of symptoms, good sleep quality, regular exercise, alcohol consumption and a body mass index between 22 and 28 were associated with better self-perceived health.Conclusions symptomsare more strongly related to self-perceived health thanhealth conditions, which suggests that the impacts ofhealth conditionsare mediated throughsymptoms, which could be important targets to improve self-perceived health.Machine learning offers a new way to assess composite constructs such as well-being or quality of life.

Journal: BMJ open (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Parental Internet Use and Lifestyle Factors as Correlates of Prolonged Screen Time of Children in Japan: Results From the Super Shokuiku School Project.

Prolonged screen time (st), which includes tv viewing and gaming on smartphones and computers, is linked to poor health.Our aim was to explore the associations between school children with prolonged st and parental internet use (iu) and lifestyles in japan.Methods children aged 6 to 13 years from the super shokuiku school project, were surveyed using questionnaires in 2016.The survey assessed the grade, sex, and lifestyle of 1,659 children and parental internet use (iu) and lifestyle using breslow's seven health behaviors.Iu consisted of internet surfing and gaming on personal computers (pc), smartphones, or consoles.Three or more hours of st was defined as prolonged st, and its correlates were analyzed using logistic regression.Results of all, 643 (38.8%) children spent ≥2 hours/day of st on a week day, whilst 153 (9.2%) children spent ≥3 hours/day.Prolonged st was significantly associated with children in higher grade (odds ratio [or] 1.74; 95% confidence interval [ci], 1.20-2.51), boys (or 2.16; 95% ci, 1.49-3.14), skipping breakfast (or 1.88; 95% ci, 1.05-3.35), late bedtime (or 1.80; 95% ci, 1.15-2.82), physical inactivity (or 1.79; 95% ci, 1.12-2.87), father's iu ≥2 hours/day (or 2.35; 95% ci, 1.52-3.63), mother's prolonged iu ≥2 hours/day (or 2.55; 95% ci, 1.43-4.52), mothers with unhealthy behaviors (or 1.81; 95% ci, 1.05-3.13), no rule setting governing screen time (or 2.41; 95% ci, 1.63-3.58), and mothers with full-time employment (or 1.95; 95% ci, 1.06-3.64).Conclusions prolonged st among japanese children was strongly associated with parental iu, no set rules for st, and mother's unhealthy lifestyles.To reduce children's st, parental engagement is warranted in the intervention strategy.

Journal: Journal of epidemiology (2018)
Publication types: Journal Article
Targeting IDH-Mutant Glioma.

Standard treatment for patients with idh-mutant gliomas with radiation therapy and chemotherapy is non-curative and associated with long-term neurotoxicity.This has created intense interest in targeted therapeutic strategies that are specifically designed of idh-mutant tumors.Much progress has been made in understanding the unique biology of idh-mutant gliomas, and now various idh-mutant-specific targeting strategies are in various phases of development.Here, we will review a range of idh-mutant targeting treatments being explored, including direct idh inhibitors, as well as strategies that take advantage of idh-mutant-specific vulnerabilities.

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2022)
Publication types: Journal Article;Review;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Antimicrobial Resistance and Predisposing Factors Associated with Catheter-Associated UTI Caused by Uropathogens Exhibiting Multidrug-Resistant Patterns: A 3-Year Retrospective Study at a Tertiary Hospital in Mogadishu, Somalia.

Widespread and rapidly emerging multidrug-resistant uropathogens, particularly carbapenem-resistant pathogens, are a public health concern that impairs the determination of empirical therapy.This study aims to evaluate the antimicrobial susceptibility profile and factors associated with catheter-associated urinary tract infection (ca-uti).Method: this retrospective study was carried out on a total of 779 urine cultures over a 3-year period.Antimicrobial sensitivity tests were performed using the standard kirby−bauer disk diffusion method.Results: the prevalence of ca-uti in our study was 12.7%; a total of 47% of cultures had multi-drug-resistant (mdr) uropathogens, and 13% of the cultures showed extended-spectrum beta-lactamase (esbl)-producing pathogens.Elderly patients, intensive care unit admissions, and associated comorbidities were correlated with higher rates of ca-uti caused by multidrug-resistant uropathogens (p 2 w at 73.1 and 69%, respectively).Higher antimicrobial resistance against ceftriaxone (85.7%), meropenem (54.3%), ertapenem (50%), ciprofloxacin (58.5%), amikacin (27%), tigecycline (7.6%), and colistin (4.6%), was revealed in the study.Conclusion: aside from the higher antimicrobial resistance against cephalosporins and fluoroquinolones, the findings of this study revealed that carbapenems are facing increased rates of antimicrobial resistance and are associated with substantial morbidity, prolonged hospitalization times, and increased healthcare expenses.

Journal: Tropical medicine and infectious disease (2022)
Publication types: Journal Article
A Case of Unilateral Retinitis Pigmentosa Associated with Full Thickness Macular Hole.

A 44-year-old saudi female presented with poor right eye vision for 3 years.Visual acuity (va) was 20/400 in the right eye and 20/20 in the left eye.Examination and imaging showed all the typical features of retinitis pigmentosa in the right eye associated with full thickness macular hole (ftmh) and an essentially normal left eye.The case underwent pars plana vitrectomy with internal limiting membrane peeling and gas tamponade that resulted in anatomical closure of the ftmh, but va remained the same.

Journal: Middle East African journal of ophthalmology (2017)
Publication types: Case Reports;Journal Article
TripletCough: Cougher Identification and Verification From Contact-Free Smartphone-Based Audio Recordings Using Metric Learning.

Cough, a symptom associated with many prevalent respiratory diseases, can serve as a potential biomarker for diagnosis and disease progression.Consequently, the development of cough monitoring systems and, in particular, automatic cough detection algorithms have been studied since the early 2000s.Recently, there has been an increased focus on the efficiency of such algorithms, as implementation on consumer-centric devices such as smartphones would provide a scalable and affordable solution for monitoring cough with contact-free sensors.Current algorithms, however, are incapable of discerning between coughs of different individuals and, thus, cannot function reliably in situations where potentially multiple individuals have to be monitored in shared environments.Therefore, we propose a weakly supervised metric learning approach for cougher recognition based on smartphone audio recordings of coughs.Our approach involves a triplet network architecture, which employs convolutional neural networks (cnns).The cnns of the triplet network learn an embedding function, which maps mel spectrograms of cough recordings to an embedding space where they are more easily distinguishable.Using audio recordings of nocturnal coughs from asthmatic patients captured with a smartphone, our approach achieved a mean accuracyof 88 % ( ± 10 % sd) on two-way identification tests with 12 enrollment samples and accuracy of 80 % and an equal error rate (eer) of 20 % on verification tests.Furthermore, our approach outperformed human raters with regard to verification tests on average by 8% in accuracy, 4% in false acceptance rate (far), and 12% in false rejection rate (frr).Our code and models are publicly available.

Journal: IEEE journal of biomedical and health informatics (2022)
Publication types: Journal Article