syedzayyan/paper_mill_benchmark huggingface dataset:
Effect of speech in noise training in the auditory and cognitive skills in children with auditory processing disorders.

S speech perception in the presence of background noise is identified as one of the most affected auditory processes in children with auditory processing disorders (apd).Mechanism of speech-in-noise perception is extensively studied and is reported to involve different auditory and cognitive skills.However previous research has reported mixed results investigating the relationship between the cognitive skills and speech-in-noise perception in children with apd.The present study intended to study the correlation between the speech-in-noise perception and other auditory and cognitive skills, and also to find the efficacy of speech-in-noise training in other auditory and cognitive skills in children with apd.Method the study imparted words in noise training utilizing monosyllable and trisyllable words in the presence of speech shaped noise and 4-talker babble.Participants included 20 children with apd, 10 of them in the experimental group who underwent the training and the remaining 10 served as controls.Auditory outcome measures included five behavioural apd tests and four digit span tests to assess cognition.Results there was a significant improvement in the speech-in-noise perception measures, temporal processing measures (gap detection test and duration pattern test) and the backward, ascending and descending digit span measures after the training in participants in the experimental group.However, spearman rank order correlation did not reveal a significant correlation between the speech-in-noise perception scores and any of the auditory or cognitive measures.Conclusion even though there was no correlation within and between auditory and cognitive measures, speech-in-noise training improved the temporal processing skills as well as the working memory skills in children with apd supporting the relationship between the said processes.These relationships with evidence from further research could be utilized to design more effective treatment strategies for children with apd.

Journal: International journal of pediatric otorhinolaryngology (2021)
Publication types: Journal Article
Effect of Static Magnetic Field onMonascus ruberM7 Based on Transcriptome Analysis.

The effects of a static magnetic field (smf) on monascus ruber m7 (m.Ruber m7) cultured on potato dextrose agar (pda) plates under smf treatment at different intensities (5, 10, and 30 m t) were investigated in this paper.The results revealed that, compared with the control (ck, no smf treatment), the smf at all tested intensities did not significantly influence the morphological characteristics of m.Ruber m7, while the intracellular and extracellular monascuspigments (mps) and extracellular citrinin (cit) of m.Ruber m7 were increased at 10 and 30 m t smf but there was no impact on the mps and cit at 5 m t smf.The transcriptome data of m.Ruber m7 cultured at 30 m t smf on pda for 3 and 7 d showed that the smf could increase the transcriptional levels of some relative genes with the primary metabolism, including the carbohydrate metabolism, amino acid metabolism, and lipid metabolism, especially in the early growing period (3 d).Smf could also affect the transcriptional levels of the related genes to the biosynthetic pathways of mps, cit, and ergosterol, and improve the transcription of the relative genes in the mitogen-activated protein kinase (mapk) signaling pathway of m.Ruber m7.These findings provide insights into a comprehensive understanding of the effects of smf on filamentous fungi.

Journal: Journal of fungi (Basel, Switzerland) (2021)
Publication types: Journal Article
Newborn screening and genetic variation of medium chain acyl-CoA dehydrogenase deficiency in the Chinese population.

S medium-chain acyl-co a dehydrogenase deficiency (mcadd) is an autosomal recessive disorder of the fatty acid oxidative metabolism.This study aimed to investigate the epidemiological characteristics, the spectrum of variation, clinical phenotype, and prognosis of mcadd in chinese newborns.Methods we retrospectively analysed newborn screening (nbs) data in the zibo area from january 2016 to march 2022 and summarized 42 cases recently reported in chinese neonates.High-performance liquid chromatography-tandem mass spectrometry (hplc-ms/ms) and next-generation sequencing (ngs) were used to detect the concentrations of carnitine in the blood spots and for diagnosis.Results a total of 183,082 newborns were detected, and six patients were diagnosed with mcadd (1/3,0514).The primary octanoylcarnitine (c8) and the octanoylcarnitine/decanoylcarnitine ratio (c8/c10) were elevated in all patients.Gene analysis revealed four known and four novel variants of the acadm gene.Five patients were asymptomatic and developed normally under dietary guidance.One child died of vaccination-induced mcadd, presenting with hypoglycemia and elevated acylcarnitines.Conclusions the incidence of mcadd in chinese newborns varies geographically from 1/222,903 to 1/30,514, and the most common pathogenic variant is c.449_452 del ctga (p.T150rfs∗4) in acadm gene with a frequency of 27.7%.Hplc-ms/ms and genetic analysis are beneficial for early prevention and good prognosis of mcadd.

Journal: Journal of pediatric endocrinology & metabolism : JPEM (2022)
Publication types: Journal Article
Mycobacterium avium subsp. paratuberculosis exploits miRNA expression to modulate lipid metabolism and macrophage polarisation pathways during infection.

Pathogenic mycobacteria including mycobacterium avium subsp.Paratuberculosis (map), the causative agent of johne's disease, manipulate host macrophages to persist and cause disease.In mycobacterial infection, highly plastic macrophages, shift between inflammatory m1 and permissive m2 phenotypes which alter the disease outcome and allow bacteria to survive intracellularly.Here we examine the impact of map infection on polarised macrophages and how increased lipid availability alters macrophage phenotype and bacterial persistence.Further, we assess if host micro rna (mi rna) are sensitive to macrophage polarisation state and how map can drive their expression to overcome innate responses.Using in vitro map infection, we find that increasing lipid availability through supplementing culture media with exogenous lipid increases cellular nitric oxide production.Lipid-associated mi rs -19a, -129, -24, and -24-3p are differentially expressed following macrophage polarisation and lipid supplementation and are further regulated during map infection.Collectively, our results highlight the importance of host lipid metabolism in map infection and demonstrate control of mi rna expression by map to favour intracellular persistence.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Face-to-Face Mentoring, Remotely Supervised Home Exercise Prehabilitation to Improve Physical Function in Patients Awaiting Kidney Transplantation: A Randomized Clinical Trial.

This study aims to explore the feasibility, safety, and effectiveness of home exercise prehabilitation on a new social platform for remote guidance to optimize the physical function of patients with end-stage renal disease awaiting kidney transplantation and provide scientific guidance on home prehabilitation exercises for patients awaiting kidney transplantation.Methods the subjects of this randomized clinical trial were randomly divided into the test and control groups.The control group maintained their exercise habits, while the trial group was given a 12-week personalized home prehabilitation exercise prescription (aerobic exercise + functional resistance exercise + flexibility exercise) on a new social platform with remote guidance.The participants' physical and cardiorespiratory fitness, quality of life, and psychological functioning were assessed before and after the intervention.The 6-min walk test (6mwt) walking distance and its percentage of attainment, the handgrip, the 5 repetition-sit-to-stand test, and the 4-m gait speed were used as primary outcome indicators, while the short form health survey sf-36 (health survey summary table) and the hospital anxiety and depression scale were used as the secondary outcome indicators.Results after 12 weeks of intervention, the changes in the 6mwt measured distance (+ 44.9 ± 40.2,p= 0.001) and the percentage of 6mwt measured distance achieved (+ 6.8 ± 5.7,p= 0.001), the handgrip (+ 2.7 ± 4.3,p= 0.028), the 5-sit-to-stand test (-1.1 ± 1.4,p= 0.005), and the 4-m walking speed (-0.3 ± 0.4,p< 0.001) of the test group (n= 21) improved significantly.In the control group (n= 16), the changes in the 6mwt measured distance (-13.1 ± 57.2), the 6mwt measured distance attainment percentage (-2.1 ± 9.1), the handgrip (-0.1 ± 2.5), the 5-sit-to-stand test value (0.6 ± 2.2), and the 4-m walking speed (0.2 ± 0.5) showed no significant difference.No significant improvement in anxiety, depression, and sf-36 was noted in both the test and control groups.Conclusion the remote coaching of home exercise pre-habilitation on a new social platform significantly improves the physical and cardiopulmonary fitness of patients with end-stage renal disease awaiting kidney transplantation.This treatment is safe and feasible in this population.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article
Dihydrotanshinone Inhibits Hepatocellular Carcinoma by Suppressing the JAK2/STAT3 Pathway.

Liver cancer is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer death.Most (75-85%) primary liver cancers occurring worldwide are hepatocellular carcinoma (hcc).The development of resistance and other drug related side effects are the prime reasons for the failure of treatment.Therefore, developing high-efficacy and low-toxicity natural anticancer agents is greatly needed in the treatment of hcc.Dihydrotanshinone (dhts) is widely used for promoting blood circulation and antitumor.The aim of the present study was to investigate the effect and mechanism of dhts-induced apoptosis of hcc, bothin vitroandin vivo.We found that dhts inhibited the growth of several hcc cells (hcclm3, smmc7721, hep3b and hep g2).Dhts induced the apoptosis of smmc7721 cells.Immunofluorescence results have showed that dhts decreased stat3 nuclear translocation.Moreover, western blot results have demonstrated that dhts suppressed the activation of jak2/stat3 signaling pathway.In addition, xenograft results have showed that dhts suppressed tumor growth of smmc7721 cellsin vivoby inhibiting the p-stat3.Thus, we demonstrated that dhts could inhibit hcc by suppressing the jak2/stat3 pathway.Dhts has potential to be a chemotherapeutic agent in hcc and merits further clinical investigation.

Journal: Frontiers in pharmacology (2021)
Publication types: Journal Article
Case of Serotonin Syndrome Initially Presenting as Diffuse Body Pain.

Serotonin syndrome is a common yet potentially life-threatening condition caused by increased serotonergic activity, usually from serotonergic pharmaceutical agents.Primary features of serotonin syndrome include mental status changes, autonomic hyperactivity, and neuromuscular abnormalities.However, the presentation of serotonin syndrome is often quite variable, leading to its under-diagnosis.Case report a 50-year-old female with chronic kidney disease on peritoneal dialysis presented to the emergency department with severe, diffuse body pain.Over the course of her hospital stay, she developed severe nausea, vomiting, and diarrhea followed by hyperreflexia and inducible clonus.Laboratory studies were remarkable for elevated liver transaminases.Review of her medications revealed several serotonergic agents, including duloxetine, tramadol, and ondansetron.Given her symptoms and the multiple serotonergic agents she was taking, she was diagnosed with serotonin syndrome.Discontinuation of the serotonergic agents led to resolution of her symptoms over the course of 4 days.Conclusions our patient's initial presentation of diffuse body pain highlights the variable presentation of serotonin syndrome.Our case also demonstrates the importance of recognizing serotonin syndrome, as the supportive ondansetron we gave to alleviate her nausea and vomiting likely exacerbated her serotonin syndrome.

Journal: The American journal of case reports (2018)
Publication types: Case Reports;Journal Article
Research and academic output evaluation for career initiation or progression: Critical issues for Health Professionals.

In current times, much stress is being laid on the evaluation of research productivity of researchers or faculty in addition to the academic qualifications and experience for the purposes of recruitment, promotion, and research grant funding.Over the years, several quantitative indices have been devised for this purpose.Some of these indices such ash-index, impact factor ande-indexare being extensively used by research organizations, universities, accreditation bodies and funding agencies for basic scientists as well as health professionals.In the absence of any formal training, these parameters or their advantages and shortcomings may not be well understood by the health professionals, especially in the early stages of their careers and sometimes, even by the evaluators.A big unanswered question is the validity of the same criteria for health professionals as are applicable for the basic science researchers.Since health professional undertaking research assignments are neither adequately trained in basic research nor can they comprehend these indices well, the same yardstick to evaluate these two widely different groups of researchers often places the health professionals at a disadvantage.this paper aims to highlight certain vital issues related to the application of research productivity indicators for recruitment and career progression of health care professionals.

Journal: Medical teacher (2022)
Publication types: Journal Article
Clinical outcomes of nicorandil administration in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: a systematic review and meta-analysis of randomized controlled trials.

Primary percutaneous coronary intervention is the treatment of choice in st-segment elevation myocardial infarction and no-reflow phenomenon is still an unsolved problem.Methods we searched pub med, em base, and cochrane central register of controlled trials for relevant randomized controlled trials.The primary endpoint was the incidence of major adverse cardiac events and the secondary endpoint was the incidences of no-reflow phenomenon and complete resolution of st-segment elevation.Results eighteen randomized controlled trials were enrolled.Nicorandil significantly reduced the incidence of no-reflow phenomenon (or, 0.46; 95% ci, 0.36-0.59; p < 0.001; i2= 0%) and major adverse cardiac events (or, 0.42; 95% ci, 0.27-0.64; p < 0.001; i2= 52%).For every single outcome of major adverse cardiac events, only heart failure and ventricular arrhythmia were significantly improved with no heterogeneity (or, 0.36; 95% ci, 0.23-0.57, p < 0.001; or, 0.43; 95% ci, 0.31-0.60, p < 0.001 respectively).A combination of intracoronary and intravenous nicorandil administration significantly reduced the incidence of major adverse cardiac events with no heterogeneity (or, 0.24; 95% ci, 0.13-0.43, p < 0.001; i2= 0%), while a single intravenous administration could not (or, 0.66; 95% ci, 0.40-1.06, p = 0.09; i2= 52%).Conclusions nicorandil can significantly improve no-reflow phenomenon and major adverse cardiac events in patients undergoing primary percutaneous coronary intervention.The beneficial effects on major adverse cardiac events might be driven by the improvements of heart failure and ventricular arrhythmia.A combination of intracoronary and intravenous administration might be an optimal usage of nicorandil.

Journal: BMC cardiovascular disorders (2021)
Publication types: Journal Article;Meta-Analysis;Research Support, Non-U.S. Gov't;Systematic Review
Quantification of autophagy flux in isolated mouse skeletal muscle fibers with overexpression of fluorescent protein mCherry-EGFP-LC3.

Evaluation of autophagy flux could be challenging for muscle fibers due to the baseline expression of m cherry-egfp-lc3 along the z-line.We established a protocol to overcome this difficulty.We overexpress m chery-egfp-lc3 in the fdb muscle of an adult mouse via electroporation.Then, we enzymatically digest fdb muscle to yield individual fibers for live cell imaging.Finally, we develop an image j-based program to eliminate the baseline striation pattern and semi-automatically quantify autophagosomes (aps) and autolysosomes (als) for autophagy flux analysis.

Journal: STAR protocols (2023)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Quality Characteristics of Semi-Dried Restructured Jerky Processed Using Super-Heated Steam.

Moisture content and water activity play important roles in extending the shelf life of dried meat products, such as jerky.However, the commonly used hot air drying process is time-consuming, costly, and adversely affects the quality of dried meat products, warranting the development of an advanced and economical drying method.This study investigated the effect of super-heated steam (shs) drying on the quality characteristics of semi-dried restructured jerky as a measure to prevent the excessive quality deterioration of meat products during drying.The control sample was dried using hot air, and the treatment samples were dried using shs at different temperatures (200, 250, and 300 °c) and for different durations (90, 105, and 120 min).With increasing shs temperature and duration, the moisture content, water activity, and residual nitrite content of the jerky were reduced.The shear force values for treatments at 200 and 250 °c were lower than those for the control.With a non-significant difference in lipid oxidation compared with the control, the overall acceptability score was the highest for the treatment at 250 °c for 120 min.In conclusion, shs (250 °c for 120 min) drying has a potential industrial value to replace the hot air drying method.

Journal: Foods (Basel, Switzerland) (2021)
Publication types: Journal Article
Heterogeneous epidemic modelling within an enclosed space and corresponding Bayesian estimation.

Since march 11th, 2020, covid-19 has been a global pandemic for more than one years due to a long and infectious incubation period.This paper establishes a heterogeneous epidemic model that divides the incubation period into infectious and non-infectious and employs the bayesian framework to model the 'diamond princess' enclosed space incident.The heterogeneity includes two different identities, two transmission methods, two different-size rooms, and six transmission stages.This model is also applicable to similar mixed structures, including closed schools, hospitals, and communities.As the covid-19 pandemic continues, our mathematical modeling can provide management insights to the governments and policymakers on how the covid-19 disease has spread and what prevention strategies still need to be taken.

Journal: Infectious Disease Modelling (2022)
Publication types: Journal Article
High impact: Examining predictors of faculty-undergraduate coauthored publication and presentation in psychology.

Despite the increasing popularity of faculty-undergraduate research, a dearth of research has investigated factors that predict the professional outcomes of these collaborations.We sought to address this gap by examining a wide range of institutional (e.g., institution type, selectivity, course load) and faculty variables (e.g., rank, years of experience, enjoyment of mentoring) potentially related to coauthored undergraduate publication and conference presentation in psychology.Negative binomial regressions were used to analyze online survey data from 244 faculty members from both graduate-serving institutions (i.e., doctoral, master's) and primarily undergraduate institutions.The results showed that, after controlling for overall research productivity, faculty at primarily undergraduate institutions were more likely to publish journal articles with undergraduates, whereas faculty at graduate-serving institutions were more likely to coauthor conference presentations with undergraduates.Institutions with higher selectivity, more support for faculty-undergraduate research, and lower course loads produced higher numbers of undergraduate publications.Faculty characteristics were even more strongly related to undergraduate research outcomes.Specifically, publication was most likely with faculty who are of higher rank, have more years of experience, spend more time on research, foster close collaborative relationships with undergraduates, and/or perceive their students as high quality and well trained.By contrast, conference presentation was most likely with faculty who work with more undergraduate students on more projects per year and/or who enjoying mentoring undergraduates.Our findings suggest ways that institutions can facilitate undergraduate publication, which we argue is an increasingly common and achievable outcome.

Journal: PloS one (2022)
Publication types: Journal Article
Exercise-Induced Improvement in Insulin-Stimulated Glucose Uptake by Rat Skeletal Muscle Is Absent in Male AS160-Knockout Rats, Partially Restored by Muscle Expression of Phosphomutated AS160, and Fully Restored by Muscle Expression of Wild-Type AS160.

One exercise session can elevate insulin-stimulated glucose uptake (isgu) in skeletal muscle, but the mechanisms remain elusive.Circumstantial evidence suggests a role for akt substrate of 160 k da (as160 or tbc1d4).We used genetic approaches to rigorously test this idea.The initial experiment evaluated the role of as160 in postexercise increase in isgu using muscles from male wild-type (wt) and as160-knockout (ko) rats.The next experiment used as160-ko rats with an adeno-associated virus (aav) approach to determine if rescuing muscle as160 deficiency could restore the ability of exercise to improve isgu.The third experiment tested if eliminating the muscle glut4 deficit in as160-ko rats via aav-delivered glut4 would enable postexercise enhancement of isgu.The final experiment used as160-ko rats and aav delivery of as160 mutated to prevent phosphorylation of ser588, thr642, and ser704 to evaluate their role in postexercise isgu.We discovered the following: 1) as160 expression was essential for postexercise increase in isgu; 2) rescuing muscle as160 expression of as160-ko rats restored postexercise enhancement of isgu; 3) restoring glut4 expression in as160-ko muscle did not rescue the postexercise increase in isgu; and 4) although as160 phosphorylation on three key sites was not required for postexercise elevation in isgu, it was essential for the full exercise effect.

Journal: Diabetes (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural