syedzayyan/paper_mill_benchmark huggingface dataset:
Carbon Dots-in-EuAPO-5 Zeolite: Triple-Emission for Multilevel Luminescence Anti-Counterfeiting.

Multilevel luminescence materials have aroused wide attention for their advanced anti-counterfeiting abilities.However, various complicated stimuli factors involved in multilevel luminescence anti-counterfeiting (ml la) limit the practical applications of such materials.Herein, carbon dots (cds) are in situ introduced into eu-substituted al po4-5 zeolite (named cds@eu apo-5) via a solvent-free thermal crystallization method, which exhibits triple emissions including pink fluorescence mainly associated with eu3+in the zeolite framework, blue fluorescence and green room temperature phosphorescence (rtp) associated with cds.Cds are uniformly embedded in the eu apo-5 zeolite matrix.Such composite displays excellent photo-, thermo-, and solvent resistance, as well as long-term storage-stability.Moreover, the triple emissions of the composite only need two kinds of common excitation lights to trigger, without involving other complicated stimuli.A triple-level luminescence anti-counterfeiting (tl la) label has been built, realizing facile, quick, and advanced luminescence anti-counterfeiting that is hard to copy.

Journal: Small (Weinheim an der Bergstrasse, Germany) (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Ectopic ovary with torsion: uncommon diagnosis made by ultrasound.

Ultrasound is an important diagnostic tool in inguinal hernia and in the evaluation of the contents of the hernia sac.This report presents a case in which ultrasound revealed a herniated ectopic ovary, complicated by torsion of its vascular pedicle, in the right labia majora.We also present a brief discussion of ovarian hernia, its potential complications, and the treatments available.

Journal: Radiologia brasileira (2017)
Publication types: Case Reports;Journal Article
Integrated multidisciplinary approach to hidradenitis suppurativa in clinical practice,.

The european hidradenitis suppurativa (hs) guidelines recommend a multidisciplinary approach for patients with hs and management of comorbidities.Objective we aimed to describe the organization of a multidisciplinary hs program and characterize the patient population.Methods we conducted a retrospective study of patients with hs undergoing prospectively defined multidisciplinary work-up including examinations by a dermatologist, plastic surgeon, smoking specialist, and nutritionist in our outpatient unit between october 2015 and january 2017.Results the study included 49 patients with a sex ratio of 1:1.A total of 73.4% of patients were smokers, 20.4% were overweight, 48.9% were obese, and 30.6% had symptoms of depression.The mean sartorius score was 30.4 (±17.6).The outcome of plastic surgery consultation was as follows: 16 patients had operations, 5 were excluded based on medical history, 9 refused surgery, and 16 remained undecided.The refusal rates for consulting with the smoking cessation and nutrition specialists were 55.8% and 69.5%, respectively.Twelve patients received antibiotics, 9 received biologics, 9 underwent medico-surgical treatment, 9 underwent surgery, and 10 were lost to follow-up.The mean visual analogue scale score for satisfaction was 8.3 (±1.6; n = 28).Conclusion an integrated multidisciplinary care model for hs is associated with high patient satisfaction.Adherence to the proposed comorbidity management was higher in female patients and related to empathetic interactions with physicians.

Journal: International journal of women's dermatology (2020)
Publication types: Journal Article
Leveraging mobile phone surveys during the COVID-19 pandemic in Ecuador and Sri Lanka: Methods, timeline and findings.

Effective and rapid decision making during a pandemic requires data not only about infections, but also about human behavior.Mobile phone surveys (mps) offer the opportunity to collect real-time data on behavior, exposure, knowledge, and perception, as well as care and treatment to inform decision making.The surveys aimed to collect coronavirus disease 2019 (covid-19) related information in ecuador and sri lanka using mobile phones.In ecuador, a knowledge, attitudes and practices (kap) survey was conducted.In sri lanka, an evaluation of a novel medicine delivery system was conducted.Using the established mobile network operator channels and technical assistance provided through the bloomberg philanthropies data for health initiative (d4h), ministries of health fielded a population-based covid-19-specific mps using surveda, the open source data collection tool developed as part of the initiative.A total of 1,185 adults in ecuador completed the mps in 14 days.A total of 5,001 adults over the age of 35 in sri lanka completed the mps in 44 days.Both samples were adjusted to the 2019 united nations population estimates to produce population-based estimates by age and sex.The ecuador covid-19 mps found that there was compliance with the mitigation strategies implemented in that country.Overall, 96.5% of ecuadorians reported wearing a face mask or face covering when leaving home.Overall, 3.8% of sri lankans used the service to receive medicines from a government clinic.Among those who used the medicine delivery service in sri lanka, 95.8% of those who used a private pharmacy received their medications within one week, and 69.9% of those using a government clinic reported the same.These studies demonstrate that mps can be conducted quickly and gather essential data.Mps can help monitor the impact of interventions and programs, and rapidly identify what works in mitigating the impact of covid-19.

Journal: PloS one (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Genetics and biochemistry remain essential in the structural era of the spliceosome.

The spliceosome is not a single macromolecular machine.Rather it is a collection of dynamic heterogeneous subcomplexes that rapidly interconvert throughout the course of a typical splicing cycle.Because of this, for many years the only high resolution structures of the spliceosome available were of smaller, isolated protein or rna components.Consequently much of our current understanding of the spliceosome derives from biochemical and genetic techniques.Now with the publication of multiple, high resolution structures of the spliceosome, some question the relevance of traditional biochemical and genetic techniques to the splicing field.We argue such techniques are not only relevant, but vital for an in depth mechanistic understanding of pre-m rna splicing.

Journal: Methods (San Diego, Calif.) (2017)
Publication types: Journal Article;Review;Research Support, N.I.H., Extramural
Design of functionalized magnetic silica multi-core composite nanoparticles for synergistic magnetic hyperthermia/radiotherapy in cancer cells.

Nanomaterials in particular the magnetic nanoparticles (mnps) offer tremendous potential for cancer treatment due to their unique intrinsic properties.Combining materials with a variety of functional groups, and forming a multifunctional nanosystem to overcome the limitations of monotherapy for cancer treatment has always been a research focus with notable difficulties.Considering the many challenges faced by radiotherapy and hyperthermia, in this study, we designed a rational strategy for magnetic hyperthermia using fe3o4@si o2@sec2@fa nanoparticles as a novel nano-radiosensitizer to simultaneously enhance the therapeutic effects of radiotherapy in the future.Fe3o4@si o2core-shell structured nanoparticles were synthesized with an appropriate silica layer thickness to maintain good saturation magnetization.The as-prepared fe3o4@si o2@sec2@fa nanoparticles had the specific absorption rate (sar)value of 57 w/g, which was below the clinically acceptable alternating magnetic field value of 4.9 × 109am-1s-1, indicating good heat generation efficiency (the temperature level δt=6-10 °c).Moreover, folate-modified nanoparticles exhibited approximately 6-fold higher cellular internalization of hela cells with no obvious cytotoxicity for the hela and mda-mb-231 cells, and lower cytotoxicity for the huvecs in a concentration range of 0-150 μg/m l.In addition, these nanoparticles were modified on the silica surface by l-selenocystine, which could enhance the elimination of tumor cells by producing reactive oxygen species under x-rays, resulting in a novel radiosensitization effect.Therefore, the as-prepared fe3o4@si o2@sec2@fa nanoparticles with good biocompatibility and active targeting would possess synergistic magnetic hyperthermia/radiotherapy effect.

Journal: Colloids and surfaces. B, Biointerfaces (2022)
Publication types: Journal Article
First principles characterisation of bio-nano interface.

Nanomaterials possess a wide range of potential applications due to their novel properties and exceptionally high activity as a result of their large surface to volume ratios compared to bulk matter.The active surface may present both advantage and risk when the nanomaterials interact with living organisms.As the overall biological impact of nanomaterials is triggered and mediated by interactions at the bio-nano interface, an ability to predict those from the atomistic descriptors, especially before the material is produced, can present enormous advantage for the development of nanotechnology.Fast screening of nanomaterials and their variations for specific biological effects can be enabled using computational materials modelling.The challenge lies in the range of scales that needs to be crossed from the material-specific atomistic representation to the relevant length scales covering typical biomolecules (proteins and lipids).In this work, we present a systematic multiscale approach that allows one to evaluate crucial interactions at the bionano interface from the first principles without any prior information about the material and thus establish links between the details of the nanomaterials structure to protein-nanoparticle interactions.As an example, an advanced computational characterization of titanium dioxide nanoparticles (6 different surfaces of rutile and anatase polymorphs) has been performed.We computed characteristics of the titanium dioxide interface with water using density functional theory for electronic density, used these parameters to derive an atomistic force field, and calculated adsorption energies for essential biomolecules on the surface of titania nanoparticles via direct atomistic simulations and coarse-grained molecular dynamics.Hydration energies, as well as adsorption energies for a set of 40 blood proteins are reported.

Journal: Physical chemistry chemical physics : PCCP (2021)
Publication types: Journal Article
Per Oral Endoscopic Myotomy for the Management of Achalasia in a Patient with Prior Lap Band, Sleeve Gastrectomy, and Roux-en-Y Gastric Bypass.

Introduction achalasia after bariatric surgery is a rare pathological entity.Nonetheless, several cases have been described in literature.Per oral endoscopic myotomy has recently emerged as the preferred approach for the management of esophageal motility disorders.Material and methods we report a video case of poem performed in a female patient with prior multiple bariatric surgical procedures.In her past medical history, she underwent to laparoscopic lap band, sleeve gastrectomy, and roux-y-gastric bypass.Results poem was carried out without complication.Myotomy was performed only for 1 cm below the cardias due to the presence of the gastro-jejunal anastomosis.Post-operative course was uneventful and oral diet was restarted after one day.At 2 months follow-up, the patient is asymptomatic with no weight regain.Conclusion we report the first case of poem after three different bariatric surgical procedure.Fibrosis due to prior interventions did not hampered poem procedure, and the shorter myotomy due to the presence of small gastric pouch did not reduced its efficacy.

Journal: Obesity surgery (2021)
Publication types: Journal Article
Brain volume and magnetic susceptibility differences in children and adolescents with prenatal alcohol exposure.

Prenatal alcohol exposure (pae) can negatively affect brain development thereby increasing the risk of cognitive deficits, behavioral challenges, and mental health problems.Brain iron is important for a number of physiological processes for healthy brain development.Animal studies show that pae reduced brain iron; however, this has not been investigated in human children with pae.Methods we studied 20 children and adolescents with pae and 44 unexposed children and adolescents aged 7.5 to 15 years.All children underwent quantitative susceptibility mapping and t1-weighted magnetic resonance imaging scans.Susceptibility and volume measurements of the caudate, putamen, pallidum, thalamus, amygdala, hippocampus, and nucleus accumbens were extracted using free surfer.Ancovas were used to compare volume and susceptibility between groups for each region of interest, controlling for age and gender.For structures where susceptibility differed by group, we also tested for an association between intelligence quotient (iq) and susceptibility.Results there were no significant group differences in susceptibility after multiple comparison correction, though the pae group had higher susceptibility in the thalamus compared to unexposed participants before correction (p = 0.032, q = 0.230).There was no association between iq and thalamus susceptibility.The pae group had significantly lower volume in the bilateral caudate, bilateral pallidum, and left putamen.Conclusions these findings suggest susceptibility may be altered in children and adolescents with pae, though more research is needed.Volume reductions are consistent with previous literature and likely underlie cognitive and behavioral deficits associated with pae.

Journal: Alcoholism, clinical and experimental research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
MdNAC4 Interacts With MdAPRR2 to Regulate Nitrogen Deficiency-Induced Leaf Senescence in Apple (Malus domestica).

Nitrogen (n) is one of the important macronutrients in plants, and n deficiency induces leaf senescence.However, the molecular mechanism underlying how n deficiency affects leaf senescence is unclear.Here, we report an apple nac tf, md nac4, that participates in n deficiency-induced leaf senescence.The senescence phenotype of apple leaves overexpressing md nac4was enhanced after n deficiency.Consistently, the chlorophyll content of transgenic leaves was significantly lower than that in the wt control leaves, the expression of chlorophyll catabolism-related genes (md nyc1,md pao, and md sgr1) was significantly higher than that in the wt controls, and the expression of chlorophyll synthesis-related genes (md hema,md chli, and md chlm) was significantly lower than that in the wt control leaves.Furthermore, md nac4 was found to directly activate the transcription of the chlorophyll catabolism-related genes md nyc1and md pao.Additionally, md nac4 was proven to interact with md aprr2 proteins bothin vitroandin vivo, and overexpression of md aprr2seemed to delay n deficiency-induced leaf senescence.Correspondingly, the chlorophyll loss of md aprr2-overexpressing (md aprr2-oe) lines was significantly lower than in wt control plants.Although downregulated, the expression of the chlorophyll synthesis-related genes md hema,md chli, and md chlmin the transgenic plants was more than twice that in the wt control plants.Taken together, our results enrich the regulatory network of leaf senescence induced by n deficiency through the interaction between md nac4 and md aprr2.

Journal: Frontiers in plant science (2022)
Publication types: Journal Article
Polyphenol-Rich Extracts of Xylopia and Aframomum Species Show Metabolic Benefits by Lowering Hepatic Lipid Accumulation in Diet-Induced Obese Mice.

Metabolic syndrome is a complex condition associated with a series of pathologies featuring glucose intolerance, diabetes, high blood pressure, dyslipidemia, microalbuminuria, overweight, and obesity.It is also related to nonalcoholic fatty liver disease (nafld), recognized as the most familiar cause of chronic liver disease worldwide.The overall prevalence of metabolic syndrome and, consequently, the one of nafld is constantly increasing worldwide.The initial management of these diseases involves lifestyle modifications, including changes in diet and physical exercise.In addition to conventional drugs like orlistat, botanicals are traditionally used to counteract these disorders, and some of them are currently under evaluation.The present work evaluated the in vivo beneficial effects of hydroalcoholic extracts of two cameroonian spices, focusing on obesity-related hepatic lipid injury in high-fat-fed c57bl/6 mice.Hydroethanolic extracts were prepared and characterized by reverse phase-high-performance liquid chromatography (hplc)-photodiode array detection and ultra performance liquid chromatography-triple time-of-flight electrospray ionization tandem mass spectroscopy (tof-esi-ms/ms) analysis.Plant extracts were orally administered for 30 days at different dose levels (100 and 200 mg kg-1body weight (bw)) to obese c57bl/6 mice.Food intake (fi) and bw were recorded daily.Plasma biochemical parameters and lipid content were estimated at the beginning and at the end of the experiment.Liver tissues were subjected to histological examinations, lipid content, as well as oxidative stress markers, and fame (fatty acid methyl esters) were estimated.Oral administration of extracts at 200 mg kg-1bw significantly reduced fi and prevented bw gain.A decrease in the weight of the liver and a decrease in the hepatic and plasma lipid content were observed.Plasma enzyme (serum glutamic-oxaloacetic transaminase, sgot; serum glutamic pyruvic transaminase, sgpt; alkaline phosphatase, alp) activities were not indicative of any organ damage.Chemical analysis suggested that phenolic acids (4-caffeoylquinic acid, p-coumaric acid 4-o-glucoside, 5-caffeoylshikimic acid, caffeic acid hexose, and 4-o-methyl gallic acid) and flavonoids (morusin derivatives, naringenin-7-o-glucoside, and homoisoflavanone) identified in the extracts could potentially justify the biological properties observed.The main findings of this study showed that xylopia parviflora(a.Rich.) benthand aframomum citratum(pereira ex oliv.Et hanb.) k.Shumdecreased hepatic lipid accumulation in high-fat-diet (hfd)-induced obese c57bl/6 mice and confirmed, at least in part, our previous in vitro and ex vivo studies.The molecular mechanisms underlying these effects are still unclear and will be explored in the future.

Journal: ACS omega (2022)
Publication types: Journal Article
Magnetic Laryngeal Reanimation as a Novel Treatment of Vocal Fold Immobility.

Vocal fold paralysis may result from surgical complications, trauma, tumor, or unknown causes.When both cords are affected, paramedian fixation can lead to life-threatening obstruction.Current treatments, including tracheostomy, cordotomy, and arytenoidectomy, compromise speech and swallow function to maintain a safe airway.To preserve all three critical laryngeal functions, otolaryngologists need a solution for bilateral vocal fold paralysis that restores motion.This study uses implantable electromagnet technology to create dynamic vocal fold movement in a proof-of-concept, preliminary model.Methods a prototype was constructed from a neodymium disk magnet and cylindrical solenoid electromagnet coupled to a battery and 3-way switch.The disk magnet was implanted in an ex vivo porcine larynx model lateral to the arytenoid, affixed with suture.The electromagnet was seated in a window cut in the thyroid cartilage.Results by driving current in two directions through the electromagnet, the vocal fold was successfully moved towards and away from the electromagnet.The neutral vocal fold opening was 5.8 mm, and the maximal opening was 7.7 mm, representing a 31.4% increase in the cross-sectional area of the glottis.Conclusion this model demonstrated proof of concept of a magnetic laryngeal reanimation device.The full device will include a respiratory effort sensor and implantable processor to time the action of the magnets with respirations.There is currently no effective treatment to re-establish vocal fold motion in patients with vocal fold paralysis.This system has the potential to give patients with bilateral vocal fold paralysis a surgical option to restore vocal fold motion.

Journal: Journal of voice : official journal of the Voice Foundation (2021)
Publication types: Journal Article
Religious Coping and Gender Moderate Trajectories of Marital Love among Black Couples.

An increasing body of work documents the roles of religion and spirituality in black american marriages.We built on this research to examine religious coping as a potential cultural resource for black marriages using a dyadic analytic approach with longitudinal data.Specifically, we investigated the effects of positive (i.e., sense of spiritual connectedness) and negative (i.e., spiritual tension or struggle) religious coping on trajectories of marital love reported by wives and husbands in 161 black, married, mixed-gender couples, and we tested the potential moderating role of spouse gender.At baseline, spouses reported on their religious coping, and they rated their marital love at baseline and during two additional home interviews conducted annually.Data were analyzed using growth curve modeling within an actor-partner interdependence modeling framework.Husbands who reported more positive religious coping at baseline exhibited relatively high and stable marital love over time, whereas those who reported less positive religious coping reported less love at baseline and exhibited declines in love over time.Wives who reported less negative religious coping at baseline were higher in marital love initially but showed declines over time, whereas those who reported more negative religious coping at baseline were lower in marital love initially but showed increases in love over time.Results highlight the importance of further research on the role of religion and religious coping in black couples' marital experiences and suggest differential roles of positive and negative religious coping for men's and women's marital love.Clinical and policy implications are discussed.

Journal: Family process (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't