syedzayyan/paper_mill_benchmark huggingface dataset:
A Study on the Innovative Use of Blockchain in the Human Resources Service Industry

The growing maturity of block chain in the context of the big data era has provided new opportunities for the development of the human resources service industry.This paper analyses the problems of the traditional hr service industry from the emerging technology of block chain and innovatively combines block chain technology with hr service industry, conceives a hr service platform based on block chain technology, and uses this platform as the center to connect job seekers, enterprises, partners, and the government, and actively explores the innovative application of block chain technology in hr service industry.The concept of “user profiling” provides new ideas and new ways to realise precise knowledge services for innovation and entrepreneurship.Under the strategic background of the internet +, mass entrepreneurship, and innovation, we integrate precise service elements into the field of personalised knowledge services for innovation and entrepreneurship, establish a user portrait model for innovation and entrepreneurship, dig deeper into the information resources and knowledge service needs of users for innovation and entrepreneurship from the perspective of portrait, and build a precise knowledge service model that fits the knowledge needs of users for “dual innovation.” it also proposes the implementation and guarantee strategies of the precise knowledge service model for innovation and entrepreneurship based on the dimensions of the concept, resources, users, and services.

Journal: Wireless Communications and Mobile Computing (2022)
Publication types: Research Article;
A Birth Cohort Study of Neurodevelopmental Outcomes from Birth to 2 Years of Age in Preterm Infants under 34 Weeks of Gestation

The tissues and organs of premature infants are immature and easily damaged by external adverse factors, leading to functional development disorders and abnormalities.Besides, the incidence of premature babies in various countries has an increasing trend, with the incidence rate exceeding 10%.Objective.This study aims to investigate the neurodevelopment and the incidence of various developmental delays, cerebral palsy, autism spectrum disorder, and audio-visual impairment in premature infants under 34 weeks of gestation from birth to 2 years of age, so as to provide the basis for early intervention of premature infants in the clinic.Methods a cohort of premature infants was established using 263 premature infants with a gestational age of 28–33 + 6 weeks who were born alive from march 1, 2018, to february 28, 2019, in four tertiary hospitals in shenzhen.In addition, 263 full-term infants of the same sex who were born in the same period in the four hospitals were randomly selected and paired in a ratio of 1 : 1 as the control group.The subjects were assessed for neurodevelopment using the gesell test scale at 6, 12, 18, and 24 months after birth (premature infants were corrected for months).We calculated the neurodevelopmental indicators of children in each month of age and the incidence of various developmental delays, cerebral palsy, autism spectrum disorder, and audio-visual impairment in the two groups.Results the results of this study showed that the cohort of premature infants with birth gestational age less than 34 weeks had higher adaptive, fine motor, and personal-social energy domain development quotient (dq) values from the corrected gestational age of 6 months to the corrected gestational age of 24 months after birth compared with the full-term cohort.And it also achieved catch-up growth in neurological development, but the detection rates of neurodevelopmental abnormalities at the corrected gestational age of 12 and 24 months were higher than those in the full-term cohort.Conclusion it is important to reduce the disability rate and degree of premature infants by strengthening the systematic management, early promotion and supervision, as well as early intervention for preterm infants with developmental abnormalities who were born at gestational age less than 34 weeks after birth.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
An Investigation in Applying Internet of Things Approach in Safe Food Dietary Plan for Better Chronic Diabetes Management among Elderly Adults

Chronic diabetes among adults is a public health concern and clinicians are trying to implement new strategies to effectively manage the disease.Traditionally, healthcare professionals are used to monitor and track the lab reports of patients.After that, they used to provide respective medicines and lifestyle plans to manage the chronic disease.The lifestyle of the patients and access to safe and secure food products is also responsible for developing chronic diseases.Thus, the internet of things (io t) has taken an utmost interest in managing diabetes.This research is going to analyze the accuracy of io t in assisting chronic diabetes management and determining food safety.To accomplish the research objectives, the researchers performed a linear regression analysis to understand whether io t devices and artificial intelligence (ai) assist in assessing food safety and diabetes management.The independent variables selected were lab test values, treatment records, epoch size of ai, and image resolution of the training dataset.Dependent variables were the accuracy of io t.Here, the accuracy of io t and ai has been determined.Moreover, the accuracy of clinicians in diabetes management has been observed.It has been found that clinicians have high variance in accuracy (max 99%) whereas machines have limited variance in accuracy (max.98%).Secondary research identified that clinicians need to be involved along with io t devices for better management of this chronic disease and help patients by providing the safest food options.

Journal: Journal of Food Quality (2022)
Publication types: Research Article;
lncRNA ABHD11-AS1, regulated by the EGFR pathway, contributes to the ovarian cancer tumorigenesis by epigenetically suppressing TIMP2

Objective epithelial ovarian cancer (eoc) is a common gynecologic malignancy characterized by extensive peritoneal metastasis and high mortality rate.Abhd11 antisense rna1 (abhd11‐as1) has recently been identified as a regulator of growth and metastasis in multiple tumors, including eoc.However, the biological function and potential mechanism of abhd11‐as1 in eoc remains poorly understood.Methods immunohistochemistry, western blot, and q rt‐pcr analysis were used to determine the expression pattern of abhd11‐as1 and epidermal growth factor receptor (egfr) in both eoc tissues and cell lines, respectively.Colony formation, transwell and wound healing assays were performed to evaluate the roles of egfr and abhd11‐as1 on the capacity of cell proliferation, migration, and invasion.Western blot analysis was performed to measure the regulation of egfr pathway on stat3.Moreover, chromatin immunoprecipitation was employed to demonstrate the interaction between abhd11‐as1 and stat3.Rna immunoprecipitation was subjected to prove the direct binding between abhd11‐as1 and ezh2.Immunofluorescence staining was performed to measure the expression and localization of timp2.Eoc mouse model was conducted for validating the role of abhd11‐as1 in vivo.Results egfr and abhd11‐as1 were highly expressed in eoc tissues and cell lines.Knockdown of egfr or abhd11‐as1 inhibited cell growth, migration, and invasion of eoc cells.Expression of abhd11‐as1 was regulated by the activation of egfr signaling pathway, mediated by stat3.Besides, abhd11‐as1 was shown to silence timp2 by binding to chromatin‐modifying enzyme ezh2.Furthermore, inhibition of egfr pathway or abhd11‐as1 repressed the tumor growth of eoc.Conclusion we defined the regulatory relationship between the egfr signaling pathway, abhd11‐as1, ezh2, and timp2 suggesting that abhd11‐as1 may act as an oncogene and a potential target for antitumor therapies in ovarian cancer.

Journal: Cancer Medicine (2019)
Publication types: Research Article;
LncAPC Drives Wnt/Β-Catenin Activation and Liver TIC Self-Renewal Through EZH2 Mediated APC Transcriptional Inhibition

Liver tumor initiating cells (tics), a small subset cells in tumor bulk, are responsible for liver tumor initiation, metastasis, and relapse.However, the regulatory mechanism of liver tics remains largely unknown.Here we found a long noncoding rna lnc apc , locating near from apc locus, was highly expressed in liver cancer and liver tics.Lnc apc was required for liver tic self‐renewal.Silencing and overexpressing lnc apc showed impaired and enhanced sphere formation capacity of liver tics, respectively.By recruiting ezh2 to apc promoter, lnc apc inhibits apc transcription and thus drives the activation of wnt/β‐catenin signaling.Attenuate binding between ezh2 and apc promoter was observed upon lnc apc knockdown.What is more, lnc apc ‐ezh2‐apc axis can be targeted to eliminate liver tics.Altogether, lnc apc promotes liver tic self‐renewal through ezh2‐dependent apc transcriptional inhibition.

Journal: Molecular Carcinogenesis (2017)
Publication types: Research Article;
Kinesin family member 15 can promote the proliferation of glioblastoma

&lt;abstract&gt; &lt;p&gt;glioblastoma is one of the most dangerous tumors for patients in clinical practice at present, and since glioblastoma originates from the brain, it will have a serious impact on patients.Therefore, more effective clinical therapeutic targets are still needed at this stage.Kinesin family member 15 (kif15) promotes proliferation in several cancers, but its effect on glioblastoma is unclear.In this study, differentially expressed gene analysis and network analysis were performed to identify critical genes affecting glioma progression.The samples were divided into a kif15 high-expression group and kif15 low-expression group, and the association between fik15 expression level and clinical characteristics was summarized and analyzed by performing medical data analysis; the effect of kif15 on glioblastoma cell proliferation was detected by employing colony formation and mtt assays.The effect of kif15 on tumor growth in mice was determined.It was found that kif15 was a potential gene affecting the progression of glioblastoma.In addition, kif15 was highly expressed in glioblastoma tumor tissues, and kif15 was correlated with tumor size, clinical stage and other clinical characteristics.After the kif15 gene was knocked out, the proliferation ability of glioblastoma was significantly inhibited.Kif15 also contributed to the growth of glioblastoma tumors in mice.Therefore, we found kif15 to be a promising clinical therapeutic target.&lt;/p&gt; &lt;/abstract&gt;

Journal: Mathematical Biosciences and Engineering (2022)
Publication types: Research Article;
MCM3AP-AS1/miR-876-5p/WNT5A axis regulates the proliferation of prostate cancer

Background although the fact that long non-coding rna mcm3ap antisense rna 1 (mcm3ap-as1) is oncogenic in several cancers is well documented, very few researchers investigate its expression and function in prostate cancer.Methods paired prostate cancer samples were selected, and expressions of mcm3ap-as1, mi r-876-5p and wnt5a were examined by q rt-pcr.Mcm3ap-as1 sh rna was transfected into lnca p and pc-3 cell lines, and then the proliferative activity and apoptosis of cancer cells were detected by cck-8 assay, ed u assay and flow cytometry analysis, respectively.Q rt-pcr and western blot were used to analyze the changes of mi r-876-5p and wnt5a.Luciferase reporter gene assay was employed to determine the regulatory relationship between mi r-876-5p and mcm3ap-as1, mi r-876-5p and wnt5a.Results mcm3ap-as1 was significantly up-regulated in cancerous tissues of prostate cancer samples, positively correlated with the expression of wnt5a, while negatively related with mi r-876-5p.After transfection of mcm3ap-as1 sh rna into prostate cancer cells, the proliferative ability of cancer cells was signally inhibited, but the apoptosis of cancer cells was increased.Mcm3ap-as1 sh rna could reduce the expression of wnt5a on both m rna and protein levels.Besides, mcm3ap-as1 was identified as a sponge of mi r-876-5p.Wnt5a was validated as a target gene of mi r- 876-5p.Conclusion mcm3ap-as1 is abnormally up-regulated in prostate cancer tissues and can modulate the proliferation and apoptosis of prostate cancer cells, which has the potential to be the “ce rna” to regulate the expression of wnt5a by targeting mi r-876-5p.

Journal: Cancer Cell International (2020)
Publication types: Research Article;
LINC01224 accelerates malignant transformation via MiR-193a-5p/CDK8 axis in gastric cancer

Background gastric cancer (gc) is a malignant tumor with a significantly high mortality rate, yet, its pathogenesis is not fully understood.Bioinformatics predicted that linc01224 is highly expressed in stomach adenocarcinoma (stad), and showed that linc01224 adsorbed mi r‐193a‐5p to target cdk8.Therefore, this study intended to verify the effect of the linc01224/mi r‐193a‐5p/cdk8 axis on the biological behavior of gastric cancer.Methods expressions of linc01224, mi r‐193a‐5p, cdk8, apoptosis‐, and emt‐related genes were analyzed using the gepia website, rt‐q pcr, in situ hybridization, and western blot as needed.Bioinformatics and dual luciferase assay were used to evaluate the relationship between linc01224, mi r‐193a‐5p, and cdk8.Functional experiments and rescue experiments (mtt assay, flow cytometry, wound healing assay, and transwell) were conducted to detect the effects of the above genes on the biological characteristics of gc cells.Tumorigenesis assay was used to verify the results of in vitro experiments.Results linc01224 adsorbed mi r‐193a‐5p to target and upregulate cdk8.The expressions of linc01224 and cdk8 were increased, while the expression of mi r‐193a‐5p was decreased in gc.Overexpressed linc01224 promoted cell viability, migration and invasion, accelerated tumor formation, attenuated apoptosis, inhibited the expressions of apoptosis‐related proteins, and promoted the expressions of emt‐related proteins, whereas silenced linc01224 led to the opposite effect.Mi r‐193a‐5p inhibitor partially offset the effect of silenced linc01224; interestingly, si cdk8 significantly reversed the effect of mi r‐193a‐5p inhibitor on gc cells.Conclusion linc01224 affects the biological behavior of gastric cancer by mediating mi r‐193a‐5p to regulate cdk8.

Journal: Cancer Medicine (2021)
Publication types: Research Article;
Long noncoding RNA UCA1 promotes cell growth, migration, and invasion by targeting miR-143-3p in oral squamous cell carcinoma

Background the long noncoding rna (lnc rna) urothelial carcinoma‐associated 1 ( uca1 ) is dysregulated in many types of tumors; however, its role in oral squamous cell carcinoma (oscc) remains unclear.This study aims to determine the effect of lnc rna uca1 on oscc.Methods fifty‐six paired oscc and adjacent nontumorous tissues were collected and the levels of uca1 , mi r‐143‐3p, and myo6 in the tissues were evaluated by q rt‐pcr.In in vitro experiments, cell viability, migration, and invasion were measured by, respectively, performing cck‐8, wound healing, and transwell assays.The target relationships among uca1 , mi r‐143‐3p, and myo6 were verified by dual‐luciferase assay.Western blot and immunohistochemistry were carried out to determine the protein levels.Xenograft mouse model was established to explore the effects of uca1 in vivo.Results levels of uca1 and myo6 were increased significantly in oscc, while the level of mi r‐143‐3p was decreased compared with the adjacent nontumorous tissues.Uca1 promoted oscc cell growth, migration, and invasion both in vitro and in vivo, while mi r‐143‐3p reversed the progression.Myo6 was validated as a target for mi r‐143‐3p, and myo6 overexpression reversed the effects of mi r‐143‐3p mimic on oscc cells.Conclusion lnc rna uca1 contributes to the proliferation and metastasis of oscc cells by targeting mi r‐143‐3p and upregulating its downstream gene myo6 .Uca1 could serve as a promising novel target therapy for treatment of oscc.

Journal: Cancer Medicine (2020)
Publication types: Research Article;
MicroRNA-223 decreases cell proliferation, migration, invasion and enhances cell apoptosis in childhood acute lymphoblastic leukemia via targeting Forkhead box O1

Objective: acute lymphoblastic leukemia (all) is a frequent malignancy in childhood.The present study was aimed to investigate the effect of mi r-223 in all and its underlying molecular mechanisms.Methods: the m rna expression of mi r-223 and foxo1 was detected by q rt-rcr in all children.The correlation between mi r-223 and clinical indexes of all was determined.Ccrf-cem and nalm-6 cells were transfected with mi r-223 mimic and mi r-223 inhibitor, respectively.The proliferation, apoptosis, invasion and migration of ccrf-cem and nalm-6 cells were measured by mtt, flow cytometry and transwell assay.The protein expression of foxo1 was detected by western blot.Additionally, dual-luciferase reporter and rna pull-down assay were performed to investigate the target gene of mi r-223 and validate their targeting relationship.Results: the m rna expression of mi r-223 was markedly down-regulated in all, but foxo1 was up-regulated.The protein expression of foxo1 was highly expressed in ccrf-cem and nalm-6 cells.The expression of mi r-223 was related to wbc, plt, rbc and risk stratification.Overexpression of mi r-223 not only inhibited cell proliferation, migration and invasion, but also induced cell apoptosis.Importantly, foxo1 was a target gene of mi r-223 in all cells.Silencing of foxo1 reversed the effects of mi r-223 inhibitor on cell proliferation, migration, invasion and apoptosis in all.Conclusions: mi r-223 could inhibit cell proliferation, migration and invasion, and promote apoptosis by targeting foxo1 in all.

Journal: Bioscience Reports (2020)
Publication types: Research Article;
Two New Co(II) Coordination Polymers: Photocatalytic Properties and Treatment Activity on Sepsis by Reducing TNF-α and IL-1β Releasing

Two novel coordination polymers (cps) containing co(ii) with the compositions of [co(l)(2,2′‐bipy)] n ( 1 ) and [co(l)(4,4′‐bipy) 4 ⋅ 2h 2 o] n ( 2 ) have been prepared via utilizing bipyridine (2,2′‐bipy for 1 and bipy, 4,4′‐bipy for 2 ) and the ligand of 1,4‐bis(3‐carboxylbenzyl)piperazine acid (h 2 l) as the co‐ligand under the hydrothermal conditions.In addition, the photodegradation of organic dyes performances for complex 1 and complex 2 have been studied.It is important that complex 2 reveals excellent dye adsorption and photodegradation performances.In addition, their protective activity on sepsis was assessed and the specific mechanism was discussed detailly.Firstly, the tnf‐α and il‐1β content released via immune cells was detected through the elisa detection kit after treated by compounds 1 and 2 .Next, the activation level of nf‐κb signaling pathway in the macrophages was determined via western blot.

Journal: ChemistrySelect (2020)
Publication types: Research Article;
A New Mixed-Ligand Coordination Polymer: Crystal Structure, Molecular Docking and Alleviating Effect on Myocarditis by Inhibiting the NLRP3-Caspase-1 Pathway in Cardiomyocytes

A new mixed‐ligand coordination polymer {[co(hbidc)(2,2′‐bpy)(h 2 o) 2 ] ⋅ 1.5h 2 o} n ( 1 ) has been successfully prepared by the reaction of co(no 3 ) 2 ⋅6h 2 o, 2, 2′‐bipyridine (2,2′‐bpy) as well as benzimidazole‐5, 6‐dicarboxylic acid (h 3 bidc) in the mixed solvent of water and dma under solvothermal conditions.Furthermore, a mechanical grinding method was used to produce the nanostructure 1 with the average size of 263 nm.The integrity of h9 c2 cardiomyocytes cell membrane after nano 1 treatment was detected by ldh detection.After nano 1 incubation, the inflammatory level in the h9 c2 cardiomyocytes was evaluated by western blot and elisa measurement.In addition, the ros accumulation in h9 c2 cardiomyocytes after nano 1 treatment was determined by h2dcfda detection assay.Finally, possible interactions between the studied complex 1 and protein has been probed using molecular docking simulation.

Journal: ChemistrySelect (2019)
Publication types: Research Article;
A New Cu(I)-Based Coordination Polymer: Crystal Structure, Molecular Docking and Protective Effect in Streptococcus-pneumoniae-Infected Mice by Promoting Immune Cell Response

In this study, a new cu(i)‐based coordination polymer (cp) whose chemical formula is [cu 4 (cn) 4 (h 2 l)](h 2 o) 2 (ch 3 cn) 4 ( 1 ) has been successfully prepared by reaction of the bipyrazolyl ligand 1h,1′h‐4,4′‐bipyrazole (h 2 l) and the cu(no 3 ) 2 ⋅3h 2 o.Furthermore, the nanoparticle of complex 1 was prepared by a mechanical grinding technique, which has good water dispersibility.In the in vivo pharmacodynamics and mechanism research, the elisa was performed to detect the content of ig g in the plasma and the lg a in the alveolar lavage fluid of streptococcus pneumoniae infected mice.After infection and nano 1 treatment, the streptococcus pneumoniae colony numbers were counted by colony‐forming units (cfu) assay for the anti‐bacterial activity evaluation.The drug‐like features of synthesized cu(i) complex that observed in experiments have been checked into details at the molecular level by performing the molecular docking.

Journal: ChemistrySelect (2019)
Publication types: Research Article;
Experimental Studies on Mechanical and Thermal Properties of Polyester Hybrid Composites Reinforced with Sansevieria Trifasciata Fibers

In the recent decades, natural fiber reinforced composite (nfrc) plays a vital role in most of the engineering applications including automobile and structural.The demand for novel natural fiber increasing steeply in recent times.Current research work aimed to develop hybrid sansevieria trifasciata fiber (hstf)/polyester composite, and researchers combined untreated sansevieria trifasciata fibers (ustfs) with na oh treated sisal fibers (nstfs) and combined them with a polyester matrix.The reinforced effect of hstfs was shown to be superior to that of nstfs.It has the tensile strength of 48.47 mpa, the flexural strength of 69.17 mpa, and the impact strength of 16.34 k j/m2.The thermal behaviour of the composite increased because of chemical treatment and hybrid composition.Polyester/hstfs show superior mechanical properties compared to other developed samples.

Journal: Advances in Materials Science and Engineering (2022)
Publication types: Research Article;
Construction and Performance Research of Reinforced Iron-Based Powder Metallurgy Materials Based on Phyllanthin as Drug Transport Carriers

Iron-based powder metallurgy materials are the largest type of powder metallurgy materials, mainly used in structural parts, bearings, and friction materials.Iron-based powder metallurgy materials have a series of advantages such as low cost, good machinability, good weldability, and heat treatment.In recent years, the enhanced iron-based powder metallurgy materials based on lavender elements have become a hot spot in the development of material transportation carriers.In order to study the effects of different hot pressing and sintering temperatures on the density, microstructure, and hardness of the enhanced iron-based powders of caladium, we conducted related studies on the structure core properties of the enhanced iron-based powders of caladium to explore whether it can be used as a drug transport carrier.The research results show that hot pressing sintering can make the powder achieve high densification at lower temperature and shorter cycle, especially in the preparation of difficult-to-form and sintered powder metallurgy materials with unique advantages.

Journal: Advances in Materials Science and Engineering (2022)
Publication types: Research Article;