syedzayyan/paper_mill_benchmark huggingface dataset:
The impact of the National Science Foundation's Innovation Corps (I-Corps) on academic innovation and entrepreneurship.

In 2011, the u.s.National science foundation created the innovation corps (i-corps) program in an effort to explore ways to translate the results of the academic research the agency has funded into new products, processes, devices, or services and move them to the marketplace.The agency established a 3-tier structure to support the implementation of the i-corps concept.Selected i-corps teams consisting of the principal investigator, an entrepreneurial lead, and an industry mentor participate in a 7-week accelerated version of the lean launchpad methodology that was first developed by steve blank at stanford university.Participating teams engage in talking to potential customers, partners, and competitors and address the challenges and the uncertainty of creating successful ventures.I-corps sites were set up to promote selected aspects of innovation and entrepreneurship ecosystems at the grantee institutions.I-corps regional nodes were charged with recruiting i-corps teams in a larger geographical area as well as stimulating a new culture of academic entrepreneurship in the institutions in their area of influence.This topical review describes the experiences and the impact of the new york city regional innovation node, which is led by the city university of new york, in partnership with new york university and columbia university.Graphic abstract

Journal: The European physical journal. D, Atomic, molecular, and optical physics (2022)
Publication types: Journal Article;Review
Financial inclusion and its influence on economic-environmental performance: demand and supply perspectives.

In this study, we want to test the impact of financial inclusion on the economic growth and the environmental quality of obor economies.We have selected four different proxies of financial inclusion, two from the perspective of the supply side and two from the perspective of the demand side.For empirical analysis, we have applied 2sls and gmm methods.In the economic growth model, among the variables of financial inclusion, only the variable of atms is positively significant in the 2sls approach; however, when we apply the gmm approach, two variables, i.e., atms and branches, are positively significant implying that supply-side financial inclusion is vital for economic growth in obor countries.On the other side, the variables of financial inclusion, whether supply side or demand side, exerted a positive impact on the co2 emissions irrespective of the estimation techniques, i.e., 2sls and gmm.These findings imply that financial inclusion, in general, causes co2 emissions to rise.

Journal: Environmental science and pollution research international (2022)
Publication types: Journal Article
Reference Trajectory Reshaping Optimization and Control of Robotic Exoskeletons for Human-Robot Co-Manipulation.

For human-robot co-manipulation by robotic exoskeletons, the interaction forces provide a communication channel through which the human and the robot can coordinate their actions.In this article, an optimization approach for reshaping the physical interactive trajectory is presented in the co-manipulation tasks, which combines impedance control to enable the human to adjust both the desired and the actual trajectories of the robot.Different from previous studies, the proposed method significantly reshapes the desired trajectory during physical human-robot interaction (p hri) based on force feedback, without requiring constant human guidance.The proposed scheme first formulates a quadratically constrained programming problem, which is then solved by neural dynamics optimization to obtain a smooth and minimal-energy trajectory similar to the natural human movement.Then, we propose an adaptive neural-network controller based on the barrier lyapunov function (blf), which enables the robot to handle the uncertain dynamics and the joint space constraints directly.To validate the proposed method, we perform experiments on the exoskeleton robot with human operators for co-manipulation tasks.The experimental results demonstrate that the proposed controller could complete the co-manipulation tasks effectively.

Journal: IEEE transactions on cybernetics (2020)
Publication types: Journal Article
Rehabilitation of Individuals With Cancer.

The survival rate of cancer is increasing as treatment improves.As patients with cancer now live longer, impairments may arise that impact quality of life (qol) and function.Therefore, a focus on qol is often as important as survival.An interdisciplinary team can achieve goal-oriented and patient-centered rehabilitation, which can optimize function and qol, and minimize impairments, restrictions, and activity limitations.In most cases, cancer patients must be active participants in therapy and exhibit carryover.Patients with cancer often have impairments that include fatigue, pain, brain fog, impaired cognition, paresis, mood disorders, difficulty with activities of daily living (adl), bowel/bladder/sexual dysfunction, and bone and soft tissue involvement.Adaptive equipment, exercise, and adl training can mitigate restrictions on activity.The trajectory and phase of the disease along the continuum of cancer care may influence the goals of rehabilitation in that time window.Qol is often influenced by participation in vocational, recreational, and home-based activities.A holistic perspective should include an analysis of distress, socioeconomic barriers, and transportation limitations when addressing issues.

Journal: Annals of rehabilitation medicine (2022)
Publication types: Journal Article
Designing highly efficient 3D porous Ni-Fe sulfide nanosheets based catalyst for the overall water splitting through component regulation.

Constructing efficient and stable bifunctional catalysts is essential to improve the conversion efficiency of overall water splitting (ows).In this work, 3d porous ni-fe sulfide nanosheets supported on nickel foam (ni-fe-s/nf) were synthesized by a facile hydrothermal method.The optimized ni3s2-fe s/nf-2 electrode realized ultra-high efficiency for oxygen evolution reaction (oer) and hydrogen evolution reaction (her).Benefiting from the unique 3d porous nanosheets structure and the strong electronic interactions between ni3s2and fe s through component regulation, low overpotentials of 253 and 262 m v are required to drive a current density of 100 m a cm-2for oer and her, respectively.Importantly, ni3s2-fe s/nf-2 bifunctional catalyst only needs 1.55 and 1.75 v at 10 and 100 m a cm-2respectively and works continuously for at least 100 h.The work thus provides an extraordinary promising catalyst for ows and can be envisioned of potential for large-scale applications.

Journal: Journal of colloid and interface science (2022)
Publication types: Journal Article
Climate change and COVID-19: Assessing the vulnerability and resilience of U.S. Indigenous communities to syndemic crises.

The rapid emergence of the covid-19 pandemic and the insidiously evolving climate crisis represent two of the most pressing public health threats to indigenous peoples in the united states.Understanding the ways in which these syndemics uniquely impact indigenous peoples, given the existing health disparities for such communities, is essential if we are to address modifiable root causes of health vulnerability and devise effective and equitable strategies to protect and improve health in the evolving climate landscape.We explore the compounding burden of the covid-19 pandemic and climate change on indigenous peoples' health, and present several case studies which outline novel indigenous approaches and perspectives that address climate change, covid-19 and future health threats.

Journal: The journal of climate change and health (2022)
Publication types: Journal Article;Review
Insights into methionine S-methylation in diverse organisms.

Dimethylsulfoniopropionate (dmsp) is an important marine anti-stress compound, with key roles in global nutrient cycling, chemotaxis and, potentially, climate regulation.Recently, diverse marine actinobacteria, α- and γ-proteobacteria were shown to initiate dmsp synthesis via the methionine (met) s-methyltransferase enzyme (mmt n), generating s-methyl-met (smm).Here we characterize a roseobacterial mmt n, providing structural and mechanistic insights into this dmsp synthesis enzyme.We propose that mmt n uses the proximity and desolvation mechanism for met s-methylation with two adjacent mmt n monomers comprising the met binding site.We also identify diverse functional mmt n enzymes in potentially symbiotic archaeal candidatus woesearchaeota and candidate phyla radiation (cpr) bacteria, and the animalcule adineta steineri, not anticipated to produce smm and/or dmsp.These diverse mmt n enzymes, alongside the larger plant mmt enzyme with an n-terminus homologous to mmt n, likely utilize the same proximity and desolvation mechanism.This study provides important insights into the catalytic mechanism of smm and/or dmsp production, and proposes roles for these compounds in secondary metabolite production, and smm cycling in diverse organisms and environments.

Journal: Nature communications (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A Study on Nonvisual Effects of Natural Light Environment in a Maternity Ward of a Hospital in Cold Area.

Thanks to the discovery of human eye photoreceptor cells, ip grc and human nonvisual channels, the nonvisual effects of light have gradually come to our vision and been rationally utilized.Along with this trend, people have expanded their demand for the light environment to both visual and nonvisual needs from only visual needs.With a good natural daylighting, parturients will find their psychological pressure and physiological pain relieved, their rehabilitation rate increased, and they get rehabilitated more quickly.This study was carried out in a representative maternity ward in harbin based on the latest research results on nonvisual effects at home and abroad.Specifically, the nonvisual effects on the natural light environment in the ward throughout the year were simulated and analyzed from the aspects of equivalent melanopic lux (eml), stimulus frequency (stim.freq), and circadian effective area (cea).During the study, natural light in the ward was measured on site, and the evaluation tool and workflow of nonvisual effects were created with the aid of grasshopper modeling platform, ladybug+honeybee, and vb script editor.The results show that the nonvisual effects of natural light on the body of parturients gradually weaken as they further go inside the ward.What is worse, in the most unfavorable all-overcast condition, daylighting on beds far away from the window does not meet the stimulus of human circadian rhythm from april to august.Therefore, additional light is required.The wards have the best nonvisual natural light environment when they are south facing and have a window to floor ratio of 0.3.

Journal: BioMed research international (2022)
Publication types: Journal Article;Retracted Publication
Technical challenges of lymphadenectomy in renal carcinoma performed with a 3D laparoscopic approach at a low pressure pneumoperitoneum due to associated pulmonary pathology - case report.

We report the case of a 63-year-old male patient presenting left renal cell carcinoma (75/70/60 mm) associated with retroperitoneal lymph node masses (peri hilar of 15 mm; lombo-aortic of 50/40/30 mm), known also with chronic obstructive pulmonary disease gold4, sleep apnea and asthma with oxygen-dependent chronic obstructive respiratory insufficiency, a bmi of 37 with grade iii obesity.Surgical treatment was performed using a 3d transperitoneal laparoscopic approach.The surgery lasted 131 minutes, with 400 ml blood loss and grade 1 clavien-dindo post operative complications.An optimal pulmonary ventilation of the patient during surgery required a low intra-abdominal pressure (10 mm hg) which raised technical difficulties due to the lymph node mass dissection from the great vessels in a small operative field on an already obese patient with a voluminous renal tumor.The 3d transperitoneal laparoscopic approach was feasible within safe oncologic parameters.

Journal: Medicine and pharmacy reports (2022)
Publication types: Case Reports;Journal Article
Salmonellaspp. infection - a continuous threat worldwide.

Acute diarrheal disease remains a major public health issue.salmonellaspp.Infection is one of the leading causes of acute diarrheal disease despite the preventive measures implemented.The clinical picture of salmonellosis varies from a common gastroenteritis to enteric fevers which are life-threatening diseases requiring a prompt and correct antibiotic treatment.In this review we present recent salmonellosis outbreaks and point out that salmonellainfections continue to be an important health issue.Numerous outbreaks of salmonellaspp.Have been reported worldwide in recent years, indicating that prevention and control programs need to be improved as well as the infectious diseases surveillance, all over the world.

Journal: Germs (2021)
Publication types: Journal Article;Review
Poly(A)-Binding Protein Cytoplasmic 1 Inhibits Porcine Epidemic Diarrhea Virus Replication by Interacting with Nucleocapsid Protein.

Porcine epidemic diarrhea virus (pedv) is the etiological agent of porcine epidemic diarrhea (ped) characterized by vomit, watery diarrhea, dehydration and high mortality.Outbreaks of highly pathogenic variant strains of pedv have resulted in extreme economic losses to the swine industry all over the world.The study of host-virus interaction can help to better understand the viral pathogenicity.Many studies have shown that poly(a)-binding proteins are involved in the replication process of various viruses.Here, we found that the infection of pedv downregulated the expression of poly(a)-binding protein cytoplasmic 1 (pabpc1) at the later infection stage in vero cells.The overexpression of pabpc1 inhibited the proliferation of pedv at transcription and translation level, and si rna-mediated depletion of pabpc1 promoted the replication of pedv.Furthermore, mass spectrometry analysis and immunoprecipitation assay confirmed that pabpc1 interacted with the nucleocapsid (n) protein of pedv.Confocal microscopy revealed the co-localizations of pabpc1 with n protein in the cytoplasm.Taken together, these results demonstrate the antiviral effect of pabpc1 against pedv replication by interacting with n protein, which increases understanding of the interaction between pedv and host.

Journal: Viruses (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Determining Factors that Influence Adoption of New Post-Stroke Sensorimotor Rehabilitation Devices in the USA.

Rehabilitation device efficacy alone does not lead to clinical practice adoption.Previous literature identifies drivers for device adoption by therapists but does not identify the best settings to introduce devices, the roles of different stakeholders including rehabilitation directors, or specific criteria to be met during device development.The objective of this work was to provide insights into these areas to increase clinical adoption of post-stroke restorative rehabilitation devices.We interviewed 107 persons including physical/occupational therapists, rehabilitation directors, and stroke survivors and performed content analysis.Unique to this work, care settings in which therapy goals are best aligned for restorative devices were found to be outpatient rehabilitation, followed by inpatient rehabilitation.Therapists are the major influencers for adoption because they typically introduce new rehabilitation devices to patients for both clinic and home use.We also learned therapists' utilization rate of a rehabilitation device influences a rehabilitation director's decision to acquire the device for facility use.Main drivers for each stakeholder are identified, along with specific criteria to add details to findings from previous literature.In addition, drivers for home adoption of rehabilitation devices by patients are identified.Rehabilitation device development should consider the best settings to first introduce the device, roles of each stakeholder, and drivers that influence each stakeholder, to accelerate successful adoption of the developed device.

Journal: IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Multiple Dermal Abscesses byTrichophyton rubrumin an Immunocompromised Patient.

We report the case of a 52-year-old man who presented with a 10 year history of multiple nodules with purulent drainage on the upper extremities.Several attempts of treatment with oral antibiotics had been unsuccessful.A skin biopsy specimen showed a dermal abscess with branched septate hyphae.A mycological culture of pus and of the biopsy specimen revealed trichophyton rubrum.Deeper dermatophytosis presenting as dermal abscesses is a rare disease which occurs normally in immunocompromised conditions.Our patient was on immunosuppressive therapy with methylprednisolone and azathioprine because of inflammatory demyelinating polyneuropathy and presented with extensive abscesses.In cases of dermal abscesses it is important to not only consider bacterial but also fungal infections as underlying cause.

Journal: Frontiers in medicine (2019)
Publication types: Case Reports;Journal Article
Pro-Apoptotic and Immunotherapeutic Effects of Carbon Nanotubes Functionalized with Recombinant Human Surfactant Protein D on Leukemic Cells.

Nanoparticles are efficient drug delivery vehicles for targeting specific organs as well as systemic therapy for a range of diseases, including cancer.However, their interaction with the immune system offers an intriguing challenge.Due to the unique physico-chemical properties, carbon nanotubes (cnts) are considered as nanocarriers of considerable interest in cancer diagnosis and therapy.Cnts, as a promising nanomaterial, are capable of both detecting as well as delivering drugs or small therapeutic molecules to tumour cells.In this study, we coupled a recombinant fragment of human surfactant protein d (rfh sp-d) with carboxymethyl-cellulose (cmc) cnts (cmc-cnt, 10-20 nm diameter) for augmenting their apoptotic and immunotherapeutic properties using two leukemic cell lines.The cell viability of aml14.3d10 or k562 cancer cell lines was reduced when cultured with cmc-mw cnt-coupled-rfh sp-d (cnt + rfh sp-d) at 24 h.Increased levels of caspase 3, 7 and cleaved caspase 9 in cnt + rfh sp-d treated aml14.3d10 and k562 cells suggested an involvement of an intrinsic pathway of apoptosis.Cnt + rfh sp-d treated leukemic cells also showed higher m rna expression of p53 and cell cycle inhibitors (p21 and p27).This suggested a likely reduction in cdc2-cyclin b1, causing g2/m cell cycle arrest and p53-dependent apoptosis in aml14.3d10 cells, while p53-independent mechanisms appeared to be in operation in k562 cells.We suggest that cnt + rfh sp-d has therapeutic potential in targeting leukemic cells, irrespective of their p53 status, and thus, it is worth setting up pre-clinical trials in animal models.

Journal: International journal of molecular sciences (2021)
Publication types: Journal Article
Fluoride and nitrate contamination of groundwater in the Loess Plateau, China: Sources and related human health risks.

Fluoride (f-) and nitrate (no3-) in groundwater have caused serious health problems worldwide.However, in the chinese loess plateau where groundwater is the primary source of drinking water, previous studies have rarely reported the health risks from fluoride and nitrate in groundwater.Therefore, we collected 105 groundwater samples (78 from shallow aquifers and 27 from deep aquifers) from the western district of the loess plateau for physicochemical and isotopic analysis to investigate the sources of f-and no3-in groundwater and associated health risks.Fluoride concentration in 73.1% of shallow groundwater and 22.2% of deep groundwater exceeds 1.5 mg/l, while no3-content in 76.3% of shallow groundwater and 51.9% of deep groundwater surpasses 50 mg/l.High-f-groundwater is associated with hco3-na, so4-na·mg and cl-na·mg types water.Fluorine-bearing minerals dissolution, cation exchange, calcite precipitation, evaporation, and anthropogenic activities contribute significantly f-in groundwater.Mixing with shallow groundwater is an important source of f-in deep groundwater.The no3-content is highest in cl type water, followed by so4type and hco3type water.No3-mainly originates from soil organic nitrogen (son), chemical fertilizers (cf), and manure and sewage (m&s).Nitrification is the dominant transformation process of nitrogen nutrients in groundwater.The hazard index (hi) values for shallow groundwater are 0.203-9.232 for adults, 0.253-11.522 for teenagers, 0.359-16.322 for children, and 0.507-23.043 for infants, while those for deep groundwater are 0.713-5.813 for adults, 0.890-7.254 for teenagers, 1.261-10.277 for children, and 1.780-14.508 for infants.Approximately 96.2% of shallow groundwater poses non-carcinogenic risks to infants and children, followed by 92.3% to teenagers, and 89.7% to adults.All deep groundwater poses non-carcinogenic risks to infants and children, followed by 92.6% to teenagers, and 74.1% to adults.This study is helpful to develop strategies for the integrated management of high fluoride or nitrate groundwater in arid areas.

Journal: Environmental pollution (Barking, Essex : 1987) (2021)
Publication types: Journal Article
GM-CSF-activated human dendritic cells promote type 1 T follicular helper cell polarization in a CD40-dependent manner.

T follicular helper (tfh) cells regulate humoral responses and present a marked phenotypic and functional diversity.Type 1 tfh (tfh1) cells were recently identified and associated with disease severity in infection and autoimmune diseases.The cellular and molecular requirements to induce human tfh1 differentiation are not known.Here, using single-cell rna sequencing (sc rnaseq) and protein validation, we report that human blood cd1c+ dendritic cells (dcs) activated by gm-csf (also known as csf2) drive the differentiation of naive cd4+ t cells into tfh1 cells.These tfh1 cells displayed typical tfh molecular features, including high levels of pd-1 (encoded by pdcd1), cxcr5 and icos.They co-expressed bcl6 and tbet (encoded by tbx21), and secreted large amounts of il-21 and ifn-γ (encoded by ifng).Mechanistically, gm-csf triggered the emergence of two dc sub-populations defined by their expression of cd40 and icos ligand (icos-l), presenting distinct phenotypes, morphologies, transcriptomic signatures and functions.Cd40high icos-llow dcs efficiently induced tfh1 differentiation in a cd40-dependent manner.In patients with mild covid-19 or latent mycobacterium tuberculosis infection, tfh1 cells were positively correlated with a cd40high icos-llow dc signature in sc rnaseq of peripheral blood mononuclear cells or blood transcriptomics, respectively.Our study uncovered a novel cd40-dependent tfh1 axis with potential physiopathological relevance to infection.This article has an associated first person interview with the first author of the paper.

Journal: Journal of cell science (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't