syedzayyan/paper_mill_benchmark huggingface dataset:
Characterization of performance fatigability during a self-paced exercise.

Pacing during a high-intensity cycling time trial (tt) appears to prevent premature task failure, but the performance fatigability during a self-paced exercise is currently unknown.Therefore, the current study characterized the time course of performance fatigability during a 4-km tt.Eleven male cyclists performed three separated tts in a crossover, counterbalanced design.The tts lasted until the end of the fast-start (fs; 600 ± 205 m), even-pace (ep; 3,600 ± 190 m), and end-spurt (es; 4,000 m) phases.Performance fatigability was characterized by using isometric maximal voluntary contractions (imvcs), whereas the muscle activation [i.e., voluntary activation (va)] and contractile function of knee extensors [e.g., peak torque of potentiated twitches (tw pt)] were evaluated using electrically evoked contractions performed before and 1 min after each specific part of the trial.Gas exchange, power output (po), and electromyographic activity (emg) were also recorded.Emg/po showed an abrupt increase followed by a continuous decrease toward the end of fs, resulting in a drop in imvc (-12%), va (-8%), and tw pt (-23%).Emg/po was stable during ep, with no additional drop on imvc, va, or tw pt (-12%, -6%, and -22%, respectively).Emg/po increased abruptly during the es, but there was no change in imvcs, va, or tw pt (-13%, -8%, and -26%, respectively).These findings demonstrate that the performance fatigability during a self-paced exercise is characterized by a large drop in contractile function and muscle activation at the beginning of the trial (i.e., fs), without additional change during the middle and end phases (i.e., ep and es).new & noteworthythe time course of performance fatigability throughout a self-paced exercise is currently unknown.The results showed that a large amount of muscle activation and contractile function impairments are attained early on a self-paced exercise (first ∼15% of the total time trial distance) and maintained throughout the test.This novel finding characterizes the performance fatigability from a contractile function and muscle activation perspective, which brings new insights for future studies focused on real-world exercise training and competition.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Orderliness of Visual Stimulus Motion Mediates Sensorimotor Coordination.

We explored the coupling of gaze and postural sway to the motion of a visual stimulus, to further understand sensorimotor coordination.Visual stimuli consisted of a horizontally oscillating red dot, moving with periodic (sine), chaotic, or aperiodic (brown noise) temporal structure.Cross recurrence quantification analysis (c rqa) was used to investigate the coupling between each measured signal with the time series of the visual stimulus position.The c rqa parameter of percent determinism indicated similar strength of coupling of gaze with either periodic or chaotic motion structures, yet weaker coupling to aperiodic stimulus motion.The c rqa parameter of maxline indicated a particular affinity toward chaotic motion.Analysis of postural coupling supports the idea that the complex periodicity of body sway affords interactivity with non-simple environmental dynamics.These results collectively strengthen the argument that chaos is an invariant and beneficial feature of biological motion, a feature which may be critical for immediate and robust coordination of the self with the environment and other environmental agents.

Journal: Frontiers in physiology (2018)
Publication types: Journal Article
Clinical Effects of Repetitive Transcranial Magnetic Stimulation of the Motor Cortex Are Associated With Changes in Resting-State Functional Connectivity in Patients With Fibromyalgia Syndrome.

In this double-blinded, sham-controlled, counterbalanced, and crossover study, we investigated the potential neuroplasticity underlying pain relief and daily function improvements following repetitive transcranial magnetic stimulation of the motor cortex (m1-r tms) in fibromyalgia syndrome (fms) patients.Specifically, we used magnetic resonance imaging (mri) to examine changes in brain structural and resting-state functional connectivity (rs fc) that correlated with improvements in fms symptomology following m1-r tms.Twenty-seven women with fms underwent real and sham treatment series, each consisting of 10 daily treatments of 10hz m1-r tms over 2 weeks, with a washout period in between.Before and after each series, participants underwent anatomical and resting-state functional mri scans and questionnaire assessments of fms-related clinical pain and functional and psychological burdens.The expected reductions in fms-related symptomology following m1-r tms occurred with the real treatment only and correlated with rs fc changes in brain areas associated with pain processing and modulation.Specifically, between the ventromedial prefrontal cortex and the m1 (t = -5.54, corrected p = .002), the amygdala and the posterior insula (t = 5.81, corrected p = .044), and the anterior and posterior insula (t = 6.01, corrected p = .029).Neither treatment significantly changed brain structure.Therefore, we provide the first evidence of an association between the acute clinical effects of m1-r tms in fms and functional alterations of brain areas that have a significant role in the experience of chronic pain.Structural changes could potentially occur over a more extended treatment period.Perspective: we show that the neurophysiological mechanism of the improvement in fibromyalgia symptoms following active, but not sham, r tms applied to m1 involves changes in resting-state functional connectivity in sensory, affective and cognitive pain processing brain areas, thus substantiating the essence of fibromyalgia syndrome as a treatable brain-based disorder.

Journal: The journal of pain (2022)
Publication types: Clinical Trial;Journal Article;Research Support, Non-U.S. Gov't
Association of Weight Loss With Type 2 Diabetes Remission Among Adults in Medically Underserved Areas: A Retrospective Cohort Study.

To examine the association between weight loss and type 2 diabetes remission among vulnerable populations living in medically underserved areas of the mid-southern united states.Design quantitative, retrospective cohort study.Setting 114 ambulatory sites and 5 adults' hospitals in the mid-south participating in a regional diabetes registry.Participants 9,900 adult patients with type 2 diabetes, stratified by remission status, with 1 year of baseline electronic medical record data, and 1 year of follow-up data for the 2015-2018 study period.Measures the outcomes were diabetes remissions, categorized asanyremission,partialremission, andcompleteremission based on the guidelines of the american diabetes association.The exposure was weight loss, calculated by the change in the body mass index (bmi) as a proxy measure.Analysis χ2tests, fisher's exact tests, and the mann-whitney u-test were used to examine the differences in patient characteristics by remission status across the 3 remission categories, as appropriate.Multiple multivariable logistic regressions adjusting for confounders were performed to estimate the adjusted odds ratios (a ors) for the associations between weight loss and diabetes remission.Results among 9,900 patients identified, a reduction of 0.3 kg/m2(standard deviation: 2.5) in the average bmi from the baseline to the follow-up was observed.10.8% achieved any type of remission, with 9.8% for partial and 1.0% for complete remissions.Greater weight loss was significantly associated with an increased likelihood of any (a or = 1.07, 95% confidence interval (ci), 1.06-1.08), partial (a or 1.06, 95% ci, 1.04-1.07), and complete diabetes remission (a or 1.10, 95% ci, 1.07-1.13).Conclusions weight loss is significantly associated with diabetes remission among patients living in medically underserved areas, but complete remission is rare.

Journal: American journal of health promotion : AJHP (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Translation of Chemical Structure into Dissipative Particle Dynamics Parameters for Simulation of Surfactant Self-Assembly.

Dissipative particle dynamics (dpd) can be used to simulate the self-assembly properties of surfactants in aqueous solutions, but in order to simulate a new compound, a large number of new parameters are required.New methods for the calculation of reliable dpd parameters directly from chemical structure are described, allowing the dpd approach to be applied to a much wider range of organic compounds.The parameters required to describe the bonded interactions between dpd beads were calculated from molecular mechanics structures.The parameters required to describe the nonbonded interactions were calculated from surface site interaction point (ssip) descriptions of molecular fragments that represent individual beads.The ssips were obtained from molecular electrostatic potential surfaces calculated using density functional theory and used in the ssimple algorithm to calculate transfer free energies between different bead liquids.This approach was used to calculate dpd parameters for a range of different types of surfactants, which include ester, amide, and sugar moieties.The parameters were used to simulate the self-assembly properties in aqueous solutions, and comparison of the results for 27 surfactants with the available experimental data shows that these dpd simulations accurately predict critical micelle concentrations, aggregation numbers, and the shapes of the supramolecular assemblies formed.The methods described here provide a general approach to determining dpd parameters for neutral organic compounds of arbitrary structure.

Journal: The journal of physical chemistry. B (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Increased Risk of COVID-19-Related Deaths among General Practitioners in Italy.

To date, data on covid-19-related death cases among physicians from different medical specialties are incomplete and scattered.In italy, available data highlight that general practitioners (gps) are, apparently, the most heavily affected group.Indeed, they currently represent 44.1% of the total covid-19 related death cases occurred among physicians, whereas they constitute about 15% of the total number of doctors.This high proportion is most likely the consequence of a work-related contagion happening especially during the first weeks of the epidemic, and persisting also in the following weeks, after the national lockdown.There are various reasons for these higher contagion rates: gps perform a lot of medical examinations daily, usually in close contact with patients.Especially at the beginning of the epidemic, gps might have had scant information on the specific safety procedures for the prevention of sars-co v-2 transmission (e.g., there was limited knowledge on the possibility of contagions deriving from asymptomatic patients) and, moreover, the availability of personal protective equipment was insufficient.Furthermore, the risk of infection is highly increased by the virus' characteristics, like its survival for several hours/days on different surfaces and its persistence in the air after an aerosolization process, with possibilities to be transmitted over distances longer than two meters.Following these observations, and considering the high cost in term of gps' lives, the covid-19 pandemic will probably revolutionize the approach to patients in general practice.Clear and effective guidelines are absolutely and urgently needed for the refinement of adequate measures to prevent sars-co v-2 infections among gps.

Journal: Healthcare (Basel, Switzerland) (2020)
Publication types: Journal Article
Multimodality approach to the diagnosis and management of constrictive pericarditis.

Despite advances in cardiovascular imaging, the diagnosis of constrictive pericarditis remains challenging.A multimodality approach to the diagnosis of cp is essential to (a) fully assess the extent of pericardial thickening and calcification, (b) detect the functional and hemodynamic consequences of the constricting pericardium, and (c) implement the optimal management strategy in these often complex cases.This case-based review highlights the role and diagnostic ambiguities of multimodality imaging.

Journal: Echocardiography (Mount Kisco, N.Y.) (2020)
Publication types: Journal Article
Antidiabetic drugs and blood pressure changes.

New era antidiabetic drugs are characterized by cardiovascular safety, including specific outcome benefits observed in randomized clinical trials (rcts).It has been postulated that the favorable effects of new antidiabetic agents are related both to better control of blood pressure (bp) levels and to activation of multiple anti-atherosclerotic properties.In this review, we aimed to assess whether antidiabetic drugs have a pressor effect in glucose control and outcome-oriented rcts, and to summarize the activated pathophysiological mechanisms relevant to bp control following the use of different antidiabetic drug classes.We also tried to determine which, if any, are the bp-lowering effects of more intense vs less intense glucose-lowering strategy irrespectively of trial antidiabetic regimen.To provide more robust results and evidence-based argumentation, a meta-analysis of placebo-controlled antidiabetic drug rcts was undertaken to estimate the ongoing bp reduction for all considered and each separate drug class alone.This quantitative synthesis might be helpful for the clinician 1) to select or avoid the use of some classes of antidiabetic agents with a potential favorable or adverse pressor effect, respectively 2) to organize the overall drug regimen in patients with diabetes mellitus and minimize side effects because of concomitant use of drugs with established pressor effect (i.e.Antihypertensive agents).This review was also organized to indicate whether bp change associated with different antidiabetic treatments may explain the specific macrovascular outcome benefits.Between all antidiabetic drugs including exogenous insulin, only sodium-glucose cotransporter 2 inhibitors produce a clinically important bp-lowering effect, but this bp reduction alone cannot explain the observed cardiovascular benefit.

Journal: Pharmacological research (2020)
Publication types: Journal Article;Meta-Analysis;Review
Monitoring Cellular Immune Responses after Consumption of Selected Probiotics in Immunocompromised Mice.

Probiotics are currently considered as one of tools to modulate immune responses under specific clinical conditions.The purpose of this study was to evaluate whether oral administration of three different probiotics (lactiplantibacillus plantarum cjlp243, cjw55-10, and cjlp475) could evoke a cell-mediated immunity in immunodeficient mice.Before conductingin vivoexperiments, we examined thein vitropotency of these probiotics for macrophage activation.After co-culture with these probiotics, bone marrow derived macrophages (bmdms) produced significant amounts of proinflammatory cytokines including interleukin-6 (il-6), il-12, and tumor necrosis factor-α (tnf-α).Levels of inducible nitric oxide synthase (inos) and co-stimulatory molecules (cd80 and cd86) were also upregulated in bmdms after treatment with some of these probiotics.To establish an immunocompromised animal model, we intraperitoneally injected mice with cyclophosphamide on day 0 and again on day 2.Starting day 3, we orally administered probiotics every day for the last 15 d.After sacrificing experimental mice on day 18, splenocytes were isolated and co-cultured with these probiotics for 3 d to measure levels of several cytokines and immune cell proliferation.Results clearly indicated that the consumption of all three probiotic strains promoted secretion of interferon-γ (ifn-γ), il-1β, il-6, il-12, and tnf-α.Nk cell cytotoxicity and proliferation of immune cells were also increased.Taken together, our data strongly suggest that consumption of some probiotics might induce cell-mediated immune responses in immunocompromised mice.

Journal: Food science of animal resources (2022)
Publication types: Journal Article
Prognostic Analysis of Patients with Acute Myocardial Infarction Undergoing Implantation of Different Stents for the First Time.

For patients with acute myocardial infarction scheduled to undergo percutaneous coronary stent implantation, in most cases a drug-eluting stent is recommended as the first choice for treatment.However, there is a lack of research on the effectiveness of bare-metal stents and drug-eluting stents on patients with different types of myocardial infarction.Our objective was to explore the effects of bare-metal stents and drug-eluting stents on patients with different types of myocardial infarction in terms of major cardiovascular incidents.This retrospective cohort study included 934 patients with myocardial infarction undergoing coronary artery stent implantation for the first time at the cardiac catheter room of the tri-service general hospital in the neihu district between 2014 and 2018.Patients' information, including demographic data, laboratory data, cardiac echocardiography results, and angiocardiography results, was collected by reviewing medical records.Cox proportional hazards regression was used to adjust the potential confounding factors, and the adjusted data were then used to compare the correlation between different types of stents and major cardiovascular incidents in patients with st-elevation myocardial infarction and non-st-elevation myocardial infarction.After the confounding factors were adjusted, in patients with st-elevation myocardial infarction receiving a drug-eluting stent compared with those receiving a bare-metal stent, it was found that the mortality risk was lower in terms of all causes of death (adj-hr = 0.26, 95% ci = 0.14-0.48,p< 0.001) and cardiogenic death (adj-hr = 0.20, 95% ci = 0.08-0.55,p= 0.002), the risk of non-fatal myocardial infarction was lower (adj-hr = 0.17, 95% ci = 0.04-0.73,p= 0.017), and there was no difference in the risk of revascularization at the lesion site (adj-hr = 0.59, 95% ci = 0.24-1.43,p= 0.243).It terms of the findings in patients with non-st-elevation myocardial infarction, those receiving a drug-eluting stent had a lower risk of revascularization at the lesion site (adj-hr = 0.48, 95% ci = 0.24-0.97,p= 0.04); however, there was no difference in the mortality risk in terms of all causes of death (adj-hr = 0.71, 95% ci = 0.37-1.35,p= 0.296) or cardiogenic death (adj-hr = 0.59, 95% ci = 0.18-1.90,p= 0.379),or in the risk of non-fatal myocardial infarction (adj-hr = 0.27, 95% ci = 0.06-1.25,p= 0.093).Compared with bare-metal stents, drug-eluting stents provide better protection against death to receivers with st-elevation myocardial infarction; however, this protection is decreased in receivers with non-st-elevation myocardial infarction.It is recommended that for patients with non-st-elevation myocardial infarction who are indicated to receive a drug-eluting stent, the clinical effectiveness of the treatment must be considered.

Journal: Journal of clinical medicine (2021)
Publication types: Journal Article
The accuracy and learning curve of active and passive dynamic navigation-guided dental implant surgery: An in vitro study.

S infrared dynamic navigation systems can be categorized into active and passive based on whether the surgical instruments can emit or only reflect light.This in vitro study aimed to compare the accuracy of implant placement and the learning curve of both active and passive dynamic navigation systems, using different registration methods.Methods implants (n = 704) were placed in 64 sets of models and divided into active (yizhime, dcarer, suzhou, china) and passive (iris-clinic, eped, kaohsiung, china) dynamic navigation groups.Both marker point-based registration (m-pbr) and feature point-based registration (f-pbr) were employed for the two groups.Based on preoperative and postoperative cone-beam computed tomography imaging, the coronal, midpoint, apical, and angular deviations were analyzed from 2d and 3d views.The operation time was recorded for each group.Results the active dynamic navigation group exhibited significantly higher accuracy than the passive dynamic navigation group (angular deviation, 4.13 ± 2.39° versus 4.62 ± 3.32°; coronal global deviation, 1.48 ± 0.60 versus 1.86 ± 1.12 mm; apical global deviation, 1.75 ± 0.81 versus 2.20 ± 1.68 mm, respectively).Significant interaction effects were observed for both registration methods and four quadrants with different dynamic navigation systems.Learning curves for the two dynamic navigation groups approached each other after 12 procedures, and finally converged after 27 procedures.Conclusions the accuracy of active dynamic navigation system was superior to that of passive dynamic navigation system.Different combinations of dynamic navigation systems, registration methods, and implanted quadrants displayed various interactions.Clinical significance our findings could provide guidance for surgeons in choosing an appropriate navigation system in various implant surgeries.Furthermore, the time required by surgeons to master the technique was calculated.Nevertheless, there are certain limitations in this in vitro study, and therefore further research is required.

Journal: Journal of dentistry (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Expression of NAC1 Restrains the Memory Formation of CD8+T Cells during Viral Infection.

Nucleus accumbens-associated protein 1 (nac1) is a transcription co-factor that has been shown to possess multiple roles in stem cell and cancer biology.However, little is known about its roles in regulation of the immune system.In the current study, we observed that expression of nac1 impacted the survival of cd8+t cells in vitro.Nac1-/-cd8+t cells displayed lower metabolism, including reduced glycolysis and oxidative phosphorylation.In vivo, compared with wild-type (wt) mice, nac1-/-mice produced a lower response to vaccinia virus (vacv) infection, and viral antigen (ag)-specific cd8+t cells decreased more slowly.Additionally, we observed that the nac1-/-mice demonstrated a stronger memory formation of viral ag-specific cd8+t cells post-viral infection.Mechanically, we identified that compared with wt cd8+t cells, the interferon regulatory factor 4 (irf4), a key transcription factor in t cell development, was highly expressed in nac1-/-cd8+t cells, insinuating that irf4 could be a critical regulatory target of nac1 in the memory formation of cd8+t cells.Our results indicate that nac1 restrains the memory formation of cd8+t cells by modulating irf4, and targeting nac1 may be exploited as a new approach to boosting cd8+t cell memory.

Journal: Viruses (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.;Research Support, N.I.H., Extramural