syedzayyan/paper_mill_benchmark huggingface dataset:
Association of serum bisphenol A levels with incident overweight and obesity risk and the mediating effect of adiponectin.

Existing cross-sectional studies indicated a positive association of bisphenol a (bpa) with overweight and obesity.However, the relationship and potential mechanisms underlying this association remain to be elucidated in prospective studies.Objective this study was designed to investigate whether serum bpa is associated with incident overweight and obesity risk, and to further explore whether adiponectin plays a mediating role in the association.Methods we measured blood bpa and adiponectin in chinese populations.The association of serum bpa with overweight and obesity risk was evaluated using multivariable logistic regression models.We further examined the mediating effect of adiponectin by causal mediation analysis.Results among 796 participants free of overweight and obesity at baseline, 133 individuals developed overweight and obesity during the follow-up period.Compared with those in the lowest quartile of serum bpa, those in the second and third quartiles were positively associated with incident overweight and obesity risk adjusting for covariates (all p-values < 0.05), whereas this association was not observed in the fourth quartile.Further spline analysis showed an inverted u-shaped dose-response relationship (pnon-linear= 0.04).Furthermore, each unit of serum log10-transformed bpa levels was associated with higher changes in waist-to-height ratio and body roundness index (all p-values < 0.05).Mediation analysis indicated significant indirect effects of adiponectin on the associations of bpa with overweight and obesity prevalence (mediation proportion: 46.08%; p = 0.02), and bmi levels (mediation proportion: 30.32%; p = 0.03).Conclusion serum bpa displayed a positive association with incident overweight and obesity risk in a non-monotonic pattern, and adiponectin might mediate the association.Further mechanistic studies are warranted.

Journal: Chemosphere (2022)
Publication types: Journal Article
Faces are not always special for attention: Effects of response-relevance and identity.

Research over the past 25 years indicates that stimulus processing is diminished when attention is engaged in a perceptually demanding task of high 'perceptual load'.These results have generalized across a variety of stimulus categories, but a controversy evolved over the question of whether perception of distractor faces (or other categories of perceptual expertise) can proceed irrespective of the level of perceptual load in the attended task.Here we identify task-relevance, and in particular identity-relevance, as a potentially important factor in explaining prior inconsistencies.In four experiments, we tested whether perceptual load in an attended letter or word task modulates the processing of famous face distractors, while varying their task-relevance.Distractor interference effects on task rts was reduced by perceptual load not only when the faces were entirely task-irrelevant, but also when the face gender was task relevant, within a name gender classification response-competition task, using famous female or male distractor faces.However, when the identity associated with the famous faces was primed by the task using their names, as in prior demonstrations that face distractors are immune to the effects of perceptual load, we were able to replicate these prior findings.Our findings demonstrate a role for identity-priming by the relevant task in determining attentional capture by faces under high perceptual load.Our results also highlight the importance of considering even relatively subtle forms of task-relevance in selective attention research.

Journal: Vision research (2021)
Publication types: Journal Article
Wasserstein GAN based Chest X-Ray Dataset Augmentation for Deep Learning Models: COVID-19 Detection Use-Case.

The novel coronavirus infection (covid-19) is still continuing to be a concern for the entire globe.Since early detection of covid-19 is of particular importance, there have been multiple research efforts to supplement the current standard rt-pcr tests.Several deep learning models, with varying effectiveness, using chest x-ray images for such diagnosis have also been proposed.While some of the models are quite promising, there still remains a dearth of training data for such deep learning models.The present paper attempts to provide a viable solution to the problem of data deficiency in covid-19 cxr images.We show that the use of a wasserstein generative adversarial network (wgan) could lead to an effective and lightweight solution.It is demonstrated that the wgan generated images are at par with the original images using inference tests on an already proposed covid-19 detection model.

Journal: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference (2022)
Publication types: Journal Article
COVID-19 in Patients on Maintenance Dialysis in the Paris Region.

Introduction coronavirus disease 2019 (covid-19) represents a serious threat to patients on maintenance dialysis.The clinical setting, mortality rate, and prognostic factors in these patients have not been well established.Methods we included all dialyzed patients with covid-19 referred to our dialysis center between march 11 and april 11, 2020.Data were obtained through the review of the medical records and were censored at the time of data cutoff, on may 11, 2020.Results forty-four patients on maintenance dialysis with covid-19 were referred to our dialysis unit during the covid-19 epidemic.Median age was 61 years (interquartile range [iqr]: 51.5-72.5); 65.9% were men.Comorbidities included hypertension (97.7%), diabetes mellitus (50%), and chronic cardiac (38.6%) and respiratory (27.3%) diseases.Initial symptoms were fever (79.5%), shortness of breath (29.5%), cough (43.2%), and diarrhea (13.6%).Three profiles of severity were distinguished based on the world health organization (who) progression scale.Forty-one (93.2%) were hospitalized and only 3 were maintained on outpatient hemodialysis.Thirty-three (75%) patients required oxygen therapy, including 15 (45.5%) who were referred to the intensive care unit.Overall, 27.3% of patients died, and 58.5% were discharged from hospital, including only 2 (13.3%) of those admitted to the intensive care unit.By multivariate analysis, cough, thrombopenia 175 mg/l were significantly associated with death.Conclusion a major outbreak of covid-19 occurred in the paris region, and spread among dialyzed patients.Our study underscores the severity of covid-19 in these patients and identified prognostic markers.

Journal: Kidney international reports (2020)
Publication types: Journal Article
Crosstalk Suppression in Individually Addressed Two-Qubit Gates in a Trapped-Ion Quantum Computer.

Crosstalk between target and neighboring spectator qubits due to spillover of control signals represents a major error source limiting the fidelity of two-qubit entangling gates in quantum computers.We show that in our laser-driven trapped-ion system coherent crosstalk error can be modeled as residual xσ[over ^]_{φ} interaction and can be actively canceled by single-qubit echoing pulses.We propose and demonstrate a crosstalk suppression scheme that eliminates all first-order crosstalk utilizing only local control of target qubits, as opposed to an existing scheme which requires control over all neighboring qubits.We report a two-qubit bell state fidelity of 99.52(6)% with the echoing pulses applied after collective gates and 99.37(5)% with the echoing pulses applied to each gate in a five-ion chain.This scheme is widely applicable to other platforms with analogous interaction hamiltonians.

Journal: Physical review letters (2022)
Publication types: Journal Article
Involvement of inducible nitric oxide synthase and mitochondrial dysfunction in the pathogenesis of enterovirus 71 infection.

Enterovirus71 (ev71) is recognized as the main causative agent of severe hand, foot and mouth disease (hfmd).However, the pathogenesis of ev71 infection has not been well characterized.Clinical evidence indicated that inducible nitric oxide synthase (i nos) induction in the lung of hfmd patients contributes to the severe symptoms of pulmonary edema.In the present study, we recruited 142 subjects including hfmd patients and controls, and serum level of nitric oxide (no) was determined.Next, cellular and animal model were used to further investigate the roles of i nos and mitochondria damage during ev71 infection.Serum no level in hfmd patients with mild or severe symptoms was higher than that in controls, and there was a trend towards an increase in the serum no level of severe cases relative to mild cases.Ev71 infection caused apoptosis and increased levels of no, i nos, superoxide dismutase (sod) activity and malondialdehyde (mda), and degraded mitochondrial membrane potential (δψm)in vitro.Pathological alterations of mitochondrial morphology were observedin vitroandin vivo.Furthermore, the expression of i nos levels in target organs including brain, spinal cord, skeletal muscle, lung and heart were increased with the progression of the pathogenesis of ev71 infection in mice.Taken together, i nos and mitochondrial damage participate in the pathogenesis of ev71 infection.

Journal: Oncotarget (2017)
Publication types: Journal Article
Controlled Release of Anti-Inflammatory and Proangiogenic Factors from Macroporous Scaffolds.

The simultaneous local delivery of anti-inflammatory and proangiogenic agents via biomaterial scaffolds presents a promising method for improving the engraftment of tissue-engineered implants while avoiding potentially detrimental systemic delivery.In this study, polydimethylsiloxane (pdms) microbeads were loaded with either anti-inflammatory dexamethasone (dex) or proangiogenic 17β-estradiol (e2) and subsequently integrated into a single macroporous scaffold to create a controlled, dual-drug delivery platform.Compared to a standard monolithic drug dispersion scaffold, macroporous scaffolds containing drug-loaded microbeads exhibited reduced initial burst release and increased durability of drug release for both agents.The incubation of scaffolds with lipopolysaccharide (lps)-stimulated m1 macrophages found that dex suppressed the production of proinflammatory and proangiogenic factors when compared to drug-free control scaffolds; however, the coincubation of macrophages with dex and e2 scaffolds restored their proangiogenic features.Following implantation, dex-loaded microbead scaffolds (dex-μbs) suppressed host cell infiltration and integration, when compared to controls.In contrast, the codelivery of dexamethasone with estrogen from the microbead scaffold (dex+e2-μbs) dampened overall host cell infiltration, but restored graft vascularization.These results demonstrate the utility of a microbead scaffold approach for the controlled, tailored, and local release of multiple drugs from an open framework implant.It further highlights the complementary impacts of local dex and e2 delivery to direct the healthy integration of implants, which has broad applications to the field of tissue engineering and regenerative medicine.Impact statement inflammatory responses and vascularization are two significant challenges associated with the engraftment of tissue-engineered implants.To overcome these challenges, we developed a microbead scaffold platform for the local delivery of anti-inflammatory and proangiogenic agents.This drug delivery system showed the potential to simultaneously control the release of multiple agents, leading to a healthy integration of implants with host tissues.This multifunctional platform could be useful to numerous cellular transplants and engineered tissues.

Journal: Tissue engineering. Part A (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Effect of Alkyl Side Chain Length on the Lithium-Ion Conductivity for Polyether Electrolytes.

The design guidelines of polymer structure to effectively promote lithium-ion conduction within the polymer electrolytes (pes) are crucial for its practical use.In this study, the electrolyte properties of a simple polyether having alkyl side chains with varied lengths (-(ch2)m-h,m= 1, 2, 4, 6, 8, and 12) were compared and established a valid design strategy based on the properties of the alkyl side chain.Various spectro-electrochemical measurements successfully connected the electrolyte properties and the alkyl side chain length.Steric hindrance of the alkyl side chain effectively suppressed the interaction between ether oxygen and lithium-ion (m≥ 2), decreasing the glass transition temperature and the activation energy of lithium-ion transfer at the electrode-electrolyte interface.The strong hydrophobic interactions aligned and/or aggregated the extended alkyl group (m≥ 8), creating a rapid lithium-ion transport pathway and enhancing lithium-ion conductivity.A clear trend was observed for the following three crucial factors determining bulk lithium-ion transport properties along with the extension of the alkyl side chain: 1) salt dissociability decreased due to the non-polarity of the alkyl side chain, 2) segmental mobility of polymer chains increased due to the internal plasticizing effect, and 3) lithium-ion transference number increased due to the inhibition of the bulky anion transport by its steric hindrance.The highest lithium-ion conductivity was confirmed for the pes with an alkyl side chain of moderate length (m= 4) at 70°c, indicating the optimized balance between salt dissociability, polymer segmental mobility, and selective lithium-ion transfer.The length of an alkyl side chain can thus be a critical factor in improving the performance of pes, including thermal stability and lithium-ion conductivity.Precise tuning of the alkyl side chain-related parameters such as steric hindrance, polarity, internal plasticizing effect, and self-alignment optimizes the polymer segmental mobility and salt dissociability, which is crucial for realizing high lithium-ion conductivity for pes.

Journal: Frontiers in chemistry (2022)
Publication types: Journal Article
Action observation activates neurons of the monkey ventrolateral prefrontal cortex.

Prefrontal cortex is crucial for exploiting contextual information for the planning and guidance of behavioral responses.Among contextual cues, those provided by others' behavior are particularly important, in primates, for selecting appropriate reactions and suppressing the inappropriate ones.These latter functions deeply rely on the ability to understand others' actions.However, it is largely unknown whether prefrontal neurons are activated by action observation.To address this issue, we recorded the activity of ventrolateral prefrontal (vlpf) neurons of macaque monkeys during the observation of videos depicting biological movements performed by a monkey or a human agent, and object motion.Our results show that a population of vlpf neurons respond to the observation of biological movements, in particular those representing goal directed actions.Many of these neurons also show a preference for the agent performing the action.The neural response is present also when part of the observed movement is obscured, suggesting that these vlpf neurons code a high order representation of the observed action rather than a simple visual description of it.

Journal: Scientific reports (2017)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Neuroinflammation and Oxidative Stress in Alzheimer's Disease; Can Nutraceuticals and Functional Foods Come to the Rescue?

Alzheimer's disease (ad), the most prevalent form of age-related dementia, is typified by progressive memory loss and spatial awareness with personality changes.The increasing socioeconomic burden associated with ad has made it a focus of extensive research.Ample scientific evidence supports the role of neuroinflammation and oxidative stress in ad pathophysiology, and there is increasing research into the possible role of anti-inflammatory and antioxidative agents as disease modifying therapies.While, the result of numerous preclinical studies has demonstrated the benefits of anti-inflammatory agents, these benefits however have not been replicated in clinical trials, necessitating a further search for more promising anti-inflammatory agents.Current understanding highlights the role of diet in the development of neuroinflammation and oxidative stress, as well as the importance of dietary interventions and lifestyle modifications in mitigating them.The current narrative review examines scientific literature for evidence of the roles (if any) of dietary components, nutraceuticals and functional foods in the prevention or management of ad.It also examines how diet/ dietary components could modulate oxidative stress/inflammatory mediators and pathways that are crucial to the pathogenesis and/or progression of ad.

Journal: Anti-inflammatory & anti-allergy agents in medicinal chemistry (2022)
Publication types: Review;Journal Article
Assessment of the healthy worker survivor effect in the relationship between psychosocial work-related factors and hypertension.

S the healthy worker survivor effect (hwse) usually leads to underestimation of the effects of harmful occupational exposures.Hwse is characterised by the concomitance of three associations: (1) job status-subsequent exposure, (2) job status-disease and (3) previous exposure-job status.No study has reported the coexistence of these associations in the relationship between psychosocial work-related factors and health.We assessed if hwse is present when measuring the effects of cumulative exposure to psychosocial work-related factors on the prevalence of hypertension in white-collar workers.Methods data were obtained from two timepoints (1991-1993 at baseline and 1999-2001 at follow-up) of a prospective cohort study.At baseline, the population was composed of 9188 white-collar employees (women: 49.9%) in quebec city.Job strain as psychosocial work-related factor and blood pressure were measured using validated methods.Job status (retirees vs employees) at follow-up was self-reported.Multiple multilevel robust poisson regressions were used to estimate prevalence ratios of hypertension and risk ratios of retirement separately by gender.We performed multiple imputations to control selection bias due to missing values.Results retirement eliminated the subsequent exposure to job strain de facto and was associated with the reduction in the prevalence of hypertension in younger (-33%) and older (-11%) men and in older women (-39%).Job strain was associated with job status in younger men and in women of any age.Conclusion data showed the presence of hwse in younger men and older women given the coexistence of the three structural associations.

Journal: Occupational and environmental medicine (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Geographic and Racial Disparities in Access to Chimeric Antigen Receptor-T Cells and Bispecific Antibodies Trials for Multiple Myeloma.

Importance the use of chimeric antigen receptor-t cell (car-t) therapy and bispecific antibodies in multiple myeloma is expanding, with encouraging early results.It is unknown if the current geographic distribution of car-t therapy and bispecific antibodies in multiple myeloma allows access for patients in need, especially for black populations, which have a higher incidence of multiple myeloma.Objective to investigate if the current geographic distribution of car-t cell therapy and bispecific antibodies for multiple myeloma allows equitable access for black patients with multiple myeloma.Design, setting, and participants this cross-sectional study of data from car-t therapy and bispecific antibodies multiple myeloma clinical trials for all available studies listed in clinical trials.gov until january 31, 2022.Only studies with 1 or more open sites in the us were analyzed.Data were analyzed february 2022.Results a total of 162 clinical trials were found, and 69 analyzed-7896 participants were either enrolled or expected to enroll, with 4386 participants (55.5%) enrolled or to be enrolled in car-t therapies clinical trials.The vast majority of clinical trials (66 [96%]) were sponsored by industry, and there were 140 clinical trials sites.The mean number of sites per trial was 8.1 (7.8 for car-t trials [range, 1-30 trials] vs 8.7 for bispecific antibodies [range, 1-26 trials]).Only 35.9% of black patients lived in a county with an open trial.For the 10 states with the highest proportion of black residents (ranging from 18.6% to 41.4%), 6 of those states (60%) had no (3 states) or less than 3 clinical trial openings (3 states) for either a car-t or bispecific antibody study.Conclusions and relevance in this cross-sectional study, we found that the geographic distribution of clinical trials for car-t and bispecific antibodies may contribute to disparities in access to the most advanced clinical trials for new multiple myeloma therapies.Since most of the ongoing trials were sponsored by industry, regulating the distribution of clinical trial sites may reduce these inequities.

Journal: JAMA network open (2022)
Publication types: Journal Article
Distribution, Ecological Factors, Molecular Diversity, and Specific PCR for Major Species of Pin Nematodes (Paratylenchusspp.) inPrunusPlantations in Spain.

This study aimed to evaluate the prevalence and distribution of paratylenchusspecies in the main areas of prunusspp.Production in spain, their ecological constraints, and new molecular tools for the specific identification of major species.Pin nematodes are recognized as plant-parasitic nematodes with a wide host range and global distribution.Therefore, understanding the environmental and agronomic factors involved in their distribution is critical to design environmental and sustainable management strategies to reduce plant damage.A total of 219 sampling sites were surveyed and 12paratylenchusspecies were identified based on an integrative taxonomic approach (p.baldaccii,p.enigmaticus,p.goodeyi,p.hamatus,p.holdemani,p.indalus,p.israelensis,p.pedrami,p.tateae,p.tenuicaudatus,p.veruculatus, and p.zurgenerus).The most common pin nematode was p.hamatus, followed by p.tenuicaudatus.Nematode abundance was influenced by climatic characteristics, soil chemical properties, and agronomic management practices.Nine explanatory variables were selected as the most strongly associated with paratylenchusdistribution.Specifically,p.tenuicaudatuswas significantly correlated with soil chemical characteristics, such as p h and carbon, sulfur, and sodium content, whereas p.goodeyiwas closely related to fields with <10 years of almond cultivation.Species-specific pcrs were developed for p.hamatusand p.tenuicaudatusand their validity was evaluated studying the molecular variability of these species and against other paratylenchusspecies.

Journal: Plant disease (2022)
Publication types: Journal Article