syedzayyan/paper_mill_benchmark huggingface dataset:
Nudging patients and surgeons to change ambulatory surgery pain management: Results from an opioid buyback program.

Optimal postoperative opioid stewardship combines adequate pain medication to control expected discomfort while avoiding abuse and community diversion of unused prescribed opioids.We hypothesized that an opioid buyback program would motivate patients to return unused opioids, and surgeons will use that data to calibrate prescribing.Methods prospective cohort study of postambulatory surgery pain management at a level ii veterans affairs rural hospital (2017-2019).Eligible patients were offered $5/unused opioid pill ($50 limit) returned to our veterans affairs hospital for proper disposal.After 6 months, buyback data was shared with each surgical specialty.Results overall, 934 of 1,880 (49.7%) eligible ambulatory surgery patients were prescribed opioids and invited to participate in the opioid buyback.We had 281 patients (30%) return 3,165 unused opioid pills; this return rate remained constant over the study period.In 2017, 62.4% of patients were prescribed an opioid; after data was shared with providers, prescriptions for opioids were reduced to 50.7% and 38.3% of eligible patients in 2018 and 2019, respectively (p < .0001).The median morphine milligram equivalents prescribed also decreased from 108.8 morphine milligram equivalents in 2017 to 75.0 morphine milligram equivalents in 2018 and sustained at 75.0 morphine milligram equivalents in 2019 (p < .001).Surgical providers, surgeries performed, patient characteristics, and 30-day refill rates were similar throughout the study period.Conclusion a small financial incentive resulted in patients returning unused opioids after ambulatory surgery.Feedback to surgeons regarding opioids returned reduced the proportion of patients prescribed an opioid and the amount of opioid after ambulatory surgery without an increase in refills.

Journal: Surgery (2021)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.
Defect Detection Method of Carbon Fiber Sucker Rod Based on Multi-Sensor Information Fusion and DBN Model.

Because of its unique characteristics of small specific gravity, high strength, and corrosion resistance, the carbon fiber sucker rod has been widely used in petroleum production.However, there is still a lack of corresponding online testing methods to detect its integrity during the process of manufacturing.Ultrasonic nondestructive testing has become one of the most accepted methods for inspection of homogeneous and fixed-thickness composites, or layered and fixed-interface-shape composites, but a carbon fiber sucker rod with multi-layered structures and irregular interlayer interfaces increases the difficulty of testing.In this paper, a novel defect detection method based on multi-sensor information fusion and a deep belief network (dbn) model was proposed to identify online its defects.A water-immersed ultrasonic array with 32 ultrasonic probes was designed to realize the online and full-coverage scanning of carbon fiber rods in radial and axial positions.Then, a multi-sensor information fusion method was proposed to integrate amplitudes and times-of-flight of the received ultrasonic pulse-echo signals with the spatial angle information of each probe into defect images with obvious defects including small cracks, transverse cracks, holes, and chapped cracks.Three geometric features and two texture features from the defect images characterizing the four types of defects were extracted.Finally, a dbn-based defect identification model was constructed and trained to identify the four types of defects of the carbon fiber rods.The testing results showed that the defect identification accuracy of the proposed method was 95.11%.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article
Comparison of 3-Year Outcomes between Early and Delayed Invasive Strategies in Older and Younger Adults with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation.

We evaluated the 3-year clinical outcomes of early invasive (ei) and delayed invasive (di) strategies in older and younger adults with non-st-segment elevation myocardial infarction (nstemi) undergoing successful new-generation drug-eluting stent (des) implantation to reflect current real-world practice.Overall, 4513 patients with nstemi were recruited from the korea acute myocardial infarction registry-national institute of health and divided into two groups according to age: group a (age ≥ 65 years, n = 2253) and group b (age < 65 years, n = 2260).These two groups were further divided into two subgroups: group ei (a1 and b1) and di (a2 and b2).The primary clinical outcome was the occurrence of major adverse cardiac and cerebrovascular events (macces), defined as all-cause death, recurrent mi (re-mi), any repeat coronary revascularization, or stroke.The secondary clinical outcome was definite or probable stent thrombosis (st).In both groups a and b, after multivariable-adjusted and propensity score-adjusted analyses, macce (group a, p = 0.137 and p = 0.255, respectively; group b, p = 0.171 and p = 0.135, respectively), all-cause death, cardiac death (cd), non-cd, re-mi, any repeat revascularization, stroke, and st rates were similar between the ei and di groups.When including only those with complex lesions, the primary and secondary clinical outcomes were not significantly different between the ei and di groups.In the era of new-generation dess, major clinical outcomes were not significantly different between the ei and di strategies in both older and younger adults with nstemi.

Journal: Journal of clinical medicine (2022)
Publication types: Journal Article
Photoelectrochemical aptasensor based on nanocomposite of CdSe@SnS2for ultrasensitive and selective detection of sulfamethazine.

A photoelectrochemical (pec) aptasensor based on cd se@sn s2nanocomposite has been developed to detect sulfamethazine (smz).The introduction of cd se into sn s2displayed an amplified pec signal, which was higher than that of pure cd se and sn s2, attributable to its enhanced light harvesting capacity and promoted pec energy conversion efficiency.Due to the formation of specific non-covalent bonds, the smz-binding aptamer (sba) has significant specificity and sensitivity.When smz was incubated on a cd se@sn s2modified electrode fixed with aminated sba, the formation of the smz/sba complex increased the space resistance of electron transfer and hindered the electronic migration between the electrodes, resulting in a decrease in photocurrent.The greater the adsorbed amount on the sba, the lower the photocurrent produced.Under optimized conditions the photocurrent response of mch/sba/cd se@sn s2/fto was inversely proportional to the smz concentration in the range 0.1 to 100 p m, with a detection limit (3 s/n) of 0.025 p m (at 0 v vs.Hg/hg cl).The recoveries ranged from 95.8 to 104% with relative standard deviations (rsds) < 6.3% (n = 3) in actual water sample.This pec aptasensor which shows considerable potential in smz detection applications has high selectivity, reproducibility, and good stability.

Journal: Mikrochimica acta (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Virulence analysis of Staphylococcus aureus in a rabbit model of infected full-thickness wound under negative pressure wound therapy.

The aim of this study was to evaluate the virulence of staphylococcus aureus in a controlled animal study using the standard sterile gauze and negative pressure wound therapy (npwt), including activation of agr, gene expression and production of virulence foctors and depth of bacterial invasion.The tissue specimens were harvested on days 0 (6 h after bacterial inoculation), 2, 4, 6, and 8 at the center of wound beds.Laser scanning confocal microscopy was performed to obtain bioluminescent images which were used to measure the depth of bacterial invasion.The agr a expression of s.aureus and the transcription and production of virulence factors including eap, spa and α-toxin were significantly different.The bacterial invasion depth was significantly less with effect of npwt.The markedly different activation of quorum sensing systems that enable cell-to-cell communication and regulation of numerous colonization and virulence factors result in distinct gene expression and pathogenicity over time in different microenvironment.Thus, the agr system represents a fundamental regulatory paradigm that can encompass different adaptive strategies and accommodate horizontally acquired virulence determinants.

Journal: Antonie van Leeuwenhoek (2018)
Publication types: Journal Article
Observations of Atmospheric Tides in the Middle and Upper Atmosphere of Mars From MAVEN and MRO.

Variability in the martian upper atmosphere is strongly linked to the lower atmosphere and much of it can be attributed to vertical wave propagation.Atmospheric tides in particular are a well-known phenomenon in the martian atmosphere that play a key role in the transport of energy as they propagate to higher altitudes.Previous theoretical predictions and observations suggest that tides producing wavenumber-2 and wavenumber-3 patterns are strongest in a fixed local time at high altitudes, however, the energy they carry and the region of deposition are not well characterized.Given the availability of atmospheric observations from several spacecraft at the same time, in this paper, the nature and behavior of tides are studied concurrently at several altitudes.Here, six intervals are identified focused at fixed low latitudes utilizing simultaneous observations of the middle and upper atmosphere from in situ and remote sensing instruments on different spacecraft.In the middle atmosphere, strong wavenumber-2 signatures are identified in the intervals north of the equator whereas, in the south, wavenumber-3 signatures are strongest.Wave signatures observed in the upper atmosphere seem to be dominated by a mix of wavenumbers-2 and -3.Seasonal variation is observed in the northern intervals, with very little interannual variability in all intervals considered.Estimates of energy based on dominant wavenumber amplitude suggest that most of the energy dissipates below ∼90 km.Furthermore, model sampled output captures the dominant wavenumbers observed in the middle atmosphere as well as the energy dissipation characteristics.

Journal: Journal of geophysical research. Planets (2022)
Publication types: Journal Article
DNA Repair Protein HELQ and XAB2 as Chemoresponse and Prognosis Biomarkers in Ascites Tumor Cells of High-Grade Serous Ovarian Cancer.

Nucleotide excision repair (ner) is an important mediator for responsiveness of platinum-based chemotherapy.Our study is aimed at investigating the ner-related genes expression in ascites tumor cells and its application in the prediction of chemoresponse in high-grade serous ovarian cancer (hgsc) patients.The relationship between 16 ner-related genes and the prognosis of ovarian cancer was analyzed in the tcga database.Ner-related genes including helq and xab2 expressions were determined via immunocytochemistry in ascites cell samples from 92 ovarian cancer patients prior to primary cytoreduction surgery.Kaplan-meier analysis and cox model were used to investigate the association between ner-related gene expression and prognosis/chemotherapeutic response.Predicting models were constructed using a training cohort of 60 patients and validated in a validation cohort of 32 patients.We found that high expression of helq and xab2 in the training cohort was associated with poor prognosis (for helq,p= 0.001, hr = 2.83, 95% ci: 1.46-5.49; for xab2,p= 0.008, hr = 2.38, 95% ci: 1.23-4.63) and platinum resistance (for helq,p< 0.001; for xab2,p= 0.006).In the validation cohort, the combination of helq and xab2 (auc = 0.863) showed the highest auc.The expression levels of helq (rr 5.7, 95% ci 1.7-19.2) and xab2 (rr 3.2, 95% ci 0.9-10.8) in ascites tumor cells were positively correlated to the risk of platinum resistance.In summary, we revealed that the expression levels of helq and xab2 are candidate predictors for primary chemotherapy responsiveness and prognosis in hgsc.Ascites cytology is applicable as a promising method for chemosensitivity prediction in hgsc.

Journal: Journal of oncology (2022)
Publication types: Journal Article
Oxidized low-density lipoprotein contributes to injury of endothelial cells via the circ_0090231/miR-9-5p/TXNIP axis.

Atherosclerosis (as) has been reported to induce severe clinical complications.Circular rna (circ rna) circ_0090231 was found to be aberrantly overexpressed in oxidized low-density lipoprotein (ox-ldl)-induced endothelial cells.This study was designed to explore the role and mechanism of circ_0090231 in ox-ldl-triggered endothelial cell injury in as.Circ_0090231, micro rna-9-5p (mi r-9-5p), and thioredoxin interacting protein (txnip) levels were detected by real-time quantitative polymerase chain reaction (rt-q pcr).Cell viability, angiogenesis, and apoptosis were detected by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-h-tetrazolium bromide (mtt), tube formation, and flow cytometry assay.Bcl-2, bax, and txnip protein levels were gauged by western blot assay.Malondialdehyde (mda), lactate dehydrogenase (ldh), and superoxide dismutase (sod) activity were determined by special kits.Tumor necrosis factor α (tnf-α), interleukin-1β (il-1β), and interleukin 6 (il-6) levels were analyzed using enzyme-linked immunosorbent assay (elisa) kits.The binding relationship between mi r-9-5p and circ_0090231 or txnip was predicted by star base, and then verified by a dual-luciferase reporter and rna immunoprecipitation (rip) assays.Circ_0090231 and txnip were increased, and mi r-9-5p was decreased in ox-ldl-treated huvecs.Moreover, circ_0090231 knockdown mitigated ox-ldl-induced huvec injury by boosting angiogenesis, oxidative stress, and inflammation, and hindering apoptosis.The mechanical analysis revealed that circ_0090231 acted as a sponge of mi r-9-5p to regulate txnip expression.Circ_0090231 could attenuate ox-ldl-mediated huvec damage by the mi r-9-5p/txnip axis, providing a promising therapeutic strategy for as treatment.

Journal: Central-European journal of immunology (2022)
Publication types: Journal Article
Ultraslow light realization using an interacting Bose-Einstein condensate trapped in a shallow optical lattice.

In this article, we propose an experimentally feasible scheme for the ultraslow light realization based on the optomechanically induced transparency (omit) phenomenon using a hybrid optomechanical system consisting of a one-dimensional bose-einstein condensate trapped in a shallow optical lattice considering the nonlinear effect of atom-atom interaction.It is shown how the system can switch from the normal mode splitting to the omit regime by manipulation of the s-wave scattering frequency of atomic collisions when the cavity is pumped at a fixed rate.Then, it is shown that an ultraslow light with a time delay more than 150 ms corresponding to a group velocity about 1 mm/s is achievable by controlling the optical lattice depth as well as the strength of atom-atom interaction and the number of atoms.Importantly, such an ultraslow light is detectable in the output of the cavity since it occurs in the frequency region of coupling-probe detuning where the reflection coefficient of the cavity is maximum.

Journal: Scientific reports (2022)
Publication types: Journal Article
Amphiphilic Cellulose Nanocrystals for Aqueous Processing of Thermoplastics.

Conventional composite formulation of cellulose nanocrystals (cncs) with thermoplastics involves melt compounding or in situ polymerisation.In this rather unconventional approach, polypropylene (pp) microparticles were finely suspended and stabilized, at varying weight loadings, in aqueous suspensions of amphiphilic cncs to enable adsorption of the nanoparticles onto the thermoplastic.In order to achieve these suspensions, cncs were modified with either octyl or hexadecyl groups.These modifications imparted hydrophobic properties to the cncs, hence increasing interfacial adhesion to the pp microparticles.The modification, however, also retained the sulfate half ester groups that ensured dispersibility in aqueous media.The cncs were evidently coated on the pp microparticles as revealed by confocal microscope imaging and had no detrimental effect on the melt properties of the pp-based composites.The approach is demonstrated to increase the young's moduli of cnc-thermoplastic composites prepared in optimum suspension loadings of 0.5 wt.% octyl-modified and 0.1 wt % hexadecyl-modified cncs.This procedure can be extended to other thermoplastics as the ability to aqueously process these composites is a major step forward in the drive for more sustainable manufacturing.

Journal: ACS applied polymer materials (2022)
Publication types: Journal Article
Systemic treatment of advanced or recurrent biliary tract cancer.

Biliary tract cancer (btc) is a disease entity comprising diverse epithelial tumors with features of cholangiocyte differentiation, and it includes cholangiocarcinoma (cca) and gallbladder cancer (gbc).Depending on its anatomical location, cholangiocarcinoma is categorized as intrahepatic (i cca), perihilar (p cca), or distal (d cca).Nearly two-thirds of patients with biliary tract cancer present with advanced disease at diagnosis and in 68-86% of resections the cancer eventually recurs either locoregionally or at a distance.Chemotherapy is the first-line therapy for advanced or recurrent btc.With the development of next-generation sequencing (ngs)-guided molecular targeted therapy, more options are available for treatment of advanced btc.Chemotherapy, and especially a triplet regimen based on gemcitabine/cisplatin/nab-paclitaxel, has had the most significant effect, and fluorouracil, leucovorin, irinotecan plus oxaliplatin (folfirinox) combined with bevacizumab is promising.Molecular targeted therapy should be based on genome sequencing and appears essential to precision medicine.Fibroblast growth factor receptor (fgfr) inhibitors and isocitrate dehydrogenase (idh) inhibitors are promising emerging targeted therapies mainly for i cca.Other targeted therapies such as anti-human epidermal growth factor receptor-2 (her2) therapies, mek inhibitors, braf inhibitors, and poly adp ribose polymerase (parp) inhibitors had tentatively displayed efficacy.Further evaluations of combination strategies in particular are needed.An immune checkpoint inhibitor (ici) alone is less efficacious, but an ici in addition to chemotherapy or radiotherapy has resulted in a response according to many case series.However, icis are still being evaluated in several ongoing studies.Combination therapies have garnered attention because of interactions between signaling pathways of carcinogenesis in btc.

Journal: Bioscience trends (2020)
Publication types: Journal Article;Review
Dihydrochalcones as Antitumor Agents.

Dihydrochalcones are a class of secondary metabolites, possessing several biological properties such as antitumor, antioxidant, antibacterial, antidiabetic, estrogenic, anti-inflammatory, antithrombotic, antiviral, neuroprotective, and immunomodulatory properties; therefore, they are currently considered promising candidates in the drug discovery process.This review intends to debate their pharmacological actions with particular attention to their antitumor activity against a panel of cancer cell lines and to the description of the inhibition mechanisms of cell proliferation such as the regulation of angiogenesis, apoptosis, etc.

Journal: Current medicinal chemistry (2022)
Publication types: Journal Article;Review
Influence of low modulus Co-Zr alloys surface modification on protein adsorption and MC3T3-E1, NIH3T3 and RAW264.7 cell behaviour.

Three types of co-x zr (x = 5, 7.5, and 10 wt.%) were treated with hydroxyapatite (ha) and used as an object to investigate the effect of ha coating on the surface and biocompatibility of co-x zr alloys.And the protein adsorption and the subsequent biological behaviour of osteoblast, fibroblast and macrophages were also investigated.The surface microstructure and wettability were assessed by scanning electron microscopy (sem) and static angle profilometer.To evaluate the biocompatibility of co-x zr and co-x zr-ha, we quantified plasma proteins adsorption by bicinchoninic acid assay (bca), cytotoxicity and cell proliferation by cell counting kit-8 (cck-8) and scanning electron microscopy (sem).The results indicated that co-x zr-ha alloy surfaces were more hydrophilic and had higher affinity to plasma proteins.Higher protein concentrations were found adsorbed onto co-7.5zr-ha and co-10zr-ha alloys.Cytotoxicity analysis indicated that ha coating improved the biocompatibility of co-x zr alloys.Furthermore, the comparable results of co-incubation of co-x zr-ha alloys with cells reveal cellular attachments to ha surfaces.Ha was successfully formed on co-x zr alloys and modified the surface structure and biocompatibility of the alloys.Co-10zr-ha and co-7.5zr-ha had the most favourable properties and cytocompatibility, and therefore can be potentially used for dental implants.

Journal: Journal of biomaterials applications (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Feasibility of a virtual nutrition intervention for adolescents with autism spectrum disorder.

Adolescents with autism spectrum disorder are at an increased risk of unhealthy eating behaviors and obesity compared to their typically developing peers.Many nutrition interventions for this population focus on improving autism spectrum disorder symptoms or managing weight rather than addressing participants' healthy eating self-efficacy.The purpose of this study was to examine a virtual implementation of a new intervention for adolescents with autism spectrum disorder, bringing adolescent learners with autism nutrition and culinary education.We used fidelity checklists, engagement records, and field notes to measure implementation.We also examined the feasibility of assessing outcome measures, including a food frequency questionnaire (ffq), psychosocial survey, height, and weight.We recruited adolescents with autism spectrum disorder aged 12-21 years.Six groups of 2-7 adolescents (27 total) participated in the intervention and pre-/post-intervention measurements.Bringing adolescent learners with autism nutrition and culinary education consisted of eight weekly lessons: exploring taste, flavor, and texture; mealtimes and rules; food groups and nutrients; moderation; beverages; cooking; well-being; sustaining healthy eating habits.The virtual implementation was feasible based on lesson attendance, participation, homework completion, fidelity, and prevalence of technical difficulties.Evaluation was also feasible based on response rate, completion, and data quality for the food frequency questionnaire, psychosocial survey, and height and weight measurements.Bringing adolescent learners with autism nutrition and culinary education may be used in virtual settings to reach diverse populations of adolescents with autism spectrum disorder.Future research is needed to evaluate the impact of bringing adolescent learners with autism nutrition and culinary education on dietary behavior and obesity outcomes.

Journal: Autism : the international journal of research and practice (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't