syedzayyan/paper_mill_benchmark huggingface dataset:
An Evaluation of the Relationship between Retinal Nerve Fiber Thickness, Cochlear Nerve Thickness, the Level of Tinnitus, and Hearing Loss in Unilateral Tinnitus Patients.

In this study, optic coherence tomography (oct) examination was performed to check whether there was any interaction between ophthalmic axonal structures in unilateral tinnitus patients, and the relationship between optic nerve thickness and cochlear nerve thickness was evaluated.Objective the aim of the study was to evaluate the relatioship between hearing loss, tinnitus, and nerve thicknesses.Study design prospective study.Setting tertiary referral university hospital.Patients the study included 88 patients with unilateral tinnitus, for which no organic cause could be found in physical examination, psychiatric evaluation, or with imaging methods.Study groups were formed of the tinnitus side and control groups were formed of the healthy side as follows: group 1 (non-tinnitus side normal hearing values - n = 30), group 2 (non-tinnitus side minimal hearing loss - n = 27), group 3 (non-tinnitus side moderate hearing loss - n = 31), group 4 (tinnitus side normal hearing values - n = 25), group 5 (tinnitus side minimal hearing loss - n = 25), and group 6 (tinnitus side moderate hearing loss - n = 38).Intervention retinal nerve fiber layer (rnfl) thickness was evaluated with oct, and the cochlear nerve cross-sectional area was evaluated with mri.Main outcome measures rnfl measurements were taken with oct from the subfoveal area (rnfl-sf) and 1.5 mm temporal to the fovea (rnfl-t μm) and nasal (rnfl-n μm) sectors.On mri, 3 measurements were taken along the nerve from the cerebellopontine angle as far as the internal auditory canal, and the mean value of these 3 measurements was calculated.Results when the groups were evaluated in respect of cochlear nerve thickness, a significant difference was seen between group 1 and both the groups with hearing loss and the tinnitus groups.In the subgroup analysis, a statistically significant difference was determined between group 1 and groups 3, 4, 5, and 6 (p = 0.013, p = 0.003, p < 0.001, and p < 0.001, respectively).When the groups were evaluated in respect of the rnfl-sf (μm), rnfl-t (μm), and rnfl-n (μm) values, the differences were determined to be statistically significant (p < 0.001 for all).In the correlation analysis, a negative correlation was determined between hearing loss and cochlear nerve diameter (r: -0.184, p = 0.014), and rnfl-n (r: -0.272, p < 0.001) and between tinnitus and cochlear nerve diameter (r: -0.536, p < 0.001), and rnfl-t (r: -0.222, p < 0.009).Conclusion the study results clearly showed a relationship between cochlear nerve fiber thickness and hearing loss and the severity of tinnitus in cases with unilateral tinnitus and that there could be neurodegenerative factors in the disease etiology.A similar relationship seen with the rnfl supports the study hypothesis.

Journal: Audiology & neuro-otology (2021)
Publication types: Journal Article
Quantitative Analysis for Chinese and US-listed Pharmaceutical Companies by the LightGBM Algorithm.

This article aims to quantitatively analyze the growth trend of listed pharmaceutical companies in the us and china by a machine learning algorithm.Background in the last two decades, the global pharmaceutical industry has faced the dilemma of low research & development (r&d) success rate.The us is the world's largest pharmaceutical market, while china is the largest emerging market.Objective to collect data from the database and apply machine learning to build the model.Methods light gbm algorithm was used to build the model and identify the factor important to the performance of pharmaceutical companies.Results the prediction accuracy for us companies was 80.3%, while it was 64.9% for chinese companies.The feature importance shows that the net profit growth rate and debt liability ratio are significant in financial indicators.The results indicated that the us may continue to dominate the global pharmaceutical industry, while several chinese pharmaceutical companies rose sharply after 2015 with the narrowing gap between the chinese and us pharmaceutical industries.Conclusion in summary, our research quantitatively analyzed the growth trend of listed pharmaceutical companies in the us and china by a machine learning algorithm, which provide a novel perspective for the global pharmaceutical industry.According to the r&d capability and profitability, 141 us-listed and 129 china-listed pharmaceutical companies were divided into four levels to evaluate the growth trend of pharmaceutical firms.

Journal: Current computer-aided drug design (2023)
Publication types: Journal Article
Nonbonding/Bonding Molecular Orbital Regulation of Nitrogen-Boron-Oxygen-embedded Blue/Green Multiresonant TADF Emitters with High Efficiency and Color Purity.

Invited for the cover of this issue is the group of h.Sasabe and j.Kido at yamagata university in japan.The image depicts the molecular structures of n-b-o embedded multi-resonant thermally activated delayed fluorescent (mr-tadf) emitters, which achieved ultra-pure deep-blue/green emission with high efficiency in oleds.Read the full text of the article at .

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (2022)
Publication types: Journal Article
Neurobehavioral Characteristics of Older Veterans With Remote Traumatic Brain Injury.

While traumatic brain injury (tbi) is common across the life span, the detailed neurobehavioral characteristics of older adults with prior tbi remain unclear.Our goal was to compare the clinical profile of older independently living veterans with and without prior tbi.Setting two veterans' retirement communities.Participants seventy-five participants with tbi and 71 without (mean age = 78 years).Design cross-sectional.Main measures tbi history was determined by the ohio state university tbi questionnaire.We assessed psychiatric and medical history via interviews and chart review and conducted measures assessing functional/lifestyle, psychiatric, and cognitive outcomes.Regression analyses (adjusted for demographics, diabetes, prior depression, substance abuse, and site) were performed to compare between tbi and non-tbi participants.Results compared with veterans without tbi, those with tbi had greater functional impairment (adjusted p = .05), endorsed more current depressive (adjusted p = .04) and posttraumatic stress disorder symptoms (adjusted p = .01), and had higher rates of prior depression and substance abuse (both adjusted ps < .01).While composite memory and language scores did not differ between groups, participants with tbi performed worse on tests of executive functioning/processing speed (adjusted p = .01).Conclusions our results suggest that tbi may have adverse long-term neurobehavioral consequences and that tbi-exposed adults may require careful screening and follow-up.

Journal: The Journal of head trauma rehabilitation (2017)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
Multipartite Correlations in Quantum Collision Models.

Quantum collision models have proved to be useful for a clear and concise description of many physical phenomena in the field of open quantum systems: thermalization, decoherence, homogenization, nonequilibrium steady state, entanglement generation, simulation of many-body dynamics, and quantum thermometry.A challenge in the standard collision model, where the system and many ancillas are all initially uncorrelated, is how to describe quantum correlations among ancillas induced by successive system-ancilla interactions.Another challenge is how to deal with initially correlated ancillas.Here we develop a tensor network formalism to address both challenges.We show that the induced correlations in the standard collision model are well captured by a matrix product state (a matrix product density operator) if the colliding particles are in pure (mixed) states.In the case of the initially correlated ancillas, we construct a general tensor diagram for the system dynamics and derive a memory-kernel master equation.Analyzing the perturbation series for the memory kernel, we go beyond the recent results concerning the leading role of two-point correlations and consider multipoint correlations (waldenfelds cumulants) that become relevant in the higher-order stroboscopic limits.These results open an avenue for the further analysis of memory effects in collisional quantum dynamics.

Journal: Entropy (Basel, Switzerland) (2022)
Publication types: Journal Article
Pretransitional behavior of viscoelastic parameters at the nematic to twist-bend nematic phase transition in flexible n-mers.

We report dynamic light scattering measurements of the orientational (frank) elastic constants and associated viscosities among a homologous series of a liquid crystalline dimer, trimer, and tetramer exhibiting a uniaxial nematic (n) to twist-bend nematic (ntb) phase transition.The elastic constants for director splay (k11), twist (k22) and bend (k33) exhibit the relations k11> k22> k33and k11/k22> 2 over the bulk of the n phase.Their behavior near the n-ntbtransition shows dependency on the parity of the number (n) of the rigid mesomorphic units in the flexible n-mers.Namely, the bend constant k33in the dimer and tetramer turns upward and starts increasing close to the transition, following a monotonic decrease through most of the n phases.In contrast, k33for the trimer flattens off just above the transition and shows no pretransitional enhancement.The twist constant k22increases pretransitionally in both even and odd n-mers, but more weakly so in the trimer, while k11increases steadily on cooling without evidence of pretransitional behavior in any n-mer.The viscosities associated with pure splay, twist-dominated twist-bend, and pure bend fluctuations in the n phase are comparable in magnitude to those of rod-like monomers.All three viscosities increase with decreasing temperature, but the bend viscosity in particular grows sharply near the n-ntbtransition.The n-ntbpretransitional behavior is shown to be in qualitative agreement with the predictions of a coarse-grained theory, which models the ntbphase as a "pseudo-layered" structure with the symmetry (but not the mass density wave) of a smectic-a* phase.

Journal: Physical chemistry chemical physics : PCCP (2019)
Publication types: Journal Article
Investigation of Peptide Toxin Diversity in Ribbon Worms (Nemertea) Using a Transcriptomic Approach.

Nemertea is a phylum of nonsegmented worms (supraphylum: spiralia), also known as ribbon worms.The members of this phylum contain various toxins, including peptide toxins.Here, we provide a transcriptomic analysis of peptide toxins in 14 nemertean species, including cephalothrixcf.simula, which was sequenced in the current study.The summarized data show that the number of toxin transcripts in the studied nemerteans varied from 12 to 82.The most represented groups of toxins were enzymes and ion channel inhibitors, which, in total, reached a proportion of 72% in some species, and the least represented were pore-forming toxins and neurotoxins, the total proportion of which did not exceed 18%.The study revealed that nemerteans possess a much greater variety of toxins than previously thought and showed that these animals are a promising object for the investigation of venom diversity and evolution, and in the search for new peptide toxins.

Journal: Toxins (2022)
Publication types: Journal Article
E6E7 regulates the HK2 expression in cervical cancer via GSK3β/FTO signal.

Cervical cancer is one of the most common cancers in women worldwide.Hexokinase 2 (hk2) is responsible for phosphorylating glucose into glucose-6-phosphate, which is required for tumorigenesis and metastasis.Methods e6e7 and fto were exogenously expressed, and their effects on hk2 m rna and protein levels were detected by rt-q pcr and western blot.Results the exogenous expression of e6e7 in si ha and c33a cells up-regulated the m rna and protein levels of intracellular hk2, up-regulated the total m6a levels, changed the expression of m6a proteins and activated the gsk3β transcription.The expression levels of mettl3 and wtap were enhanced, whereas the expression of fto and alkbh5 were decreased.In addition, fto down-regulated the m rna and protein levels of hk2.Fto overexpression partially inhibited the up-regulated expression of hk2 caused by e6e7.Furthermore, fto overexpression increased the level of hk2 pre-m rna in the nucleus and decreased the level of mature hk2 m rna in the cytoplasm.We also found that gsk3β overexpression enhanced fto ubiquitination and decreased fto protein levels.Conclusion this study found that e6e7 oncogene activates the transcription of gsk3β; gsk3β can promote the ubiquitination-proteasomal degradation of fto and reduce the level of fto protein; fto inhibits the maturation and translation of hk2 m rna by retaining hk2 pre-m rna in the nucleus.

Journal: Archives of biochemistry and biophysics (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Neural detection of changes in amplitude rise time in infancy.

Amplitude rise times play a crucial role in the perception of rhythm in speech, and reduced perceptual sensitivity to differences in rise time is related to developmental language difficulties.Amplitude rise times also play a mechanistic role in neural entrainment to the speech amplitude envelope.Using an erp paradigm, here we examined for the first time whether infants at the ages of seven and eleven months exhibit an auditory mismatch response to changes in the rise times of simple repeating auditory stimuli.We found that infants exhibited a mismatch response (mmr) to all of the oddball rise times used for the study.The mmr was more positive at seven than eleven months of age.At eleven months, there was a shift to a mismatch negativity (mmn) that was more pronounced over left fronto-central electrodes.The mmr over right fronto-central electrodes was sensitive to the size of the difference in rise time.The results indicate that neural processing of changes in rise time is present at seven months, supporting the possibility that early speech processing is facilitated by neural sensitivity to these important acoustic cues.

Journal: Developmental cognitive neuroscience (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Conglomerate ring and tract-like enhancement lesions: Neuroimaging inListeria monocytogenesbrain abscess.

This report aims to describe a characteristic neuroimaging of listeria monocytogenesbrain abscess in predisposed patients.A 56-year-old man presented with fever and headache for 3 weeks.Cerebrospinal fluid (csf) revealed pleocytosis with lymphocytosis, high protein, and low glucose.Both hemoculture and csf culture yielded l monocytogenes.another case is a 23-year-old woman with systemic lupus erythematosus, who presented with fever, headache and left hemiparesis.Csf showed pleocytosis with polymorphonuclear cells predominance and low glucose.Hemoculture positive for l monocytogenes.their mri brain revealed conglomerate ring and tract-like enhancement lesions at the right parietotemporal lobe.The patients were diagnosed with l monocytogenesbrain abscess.They received a high dose of ceftriaxone and ampicillin for 6 weeks.The clinical and mri at the end of treatment was a substantial improvement.Our information can help the physician concern about this pathogen in patients who presented with brain abscess and had these mri findings.

Journal: Radiology case reports (2022)
Publication types: Case Reports;Journal Article
Does Organizational Cronyism Lead to Lower Employee Performance? Examining the Mediating Role of Employee Engagement and Moderating Role of Islamic Work Ethics.

In this research, using a time-lagged approach, we investigated the relationship between organizational cronyism and employee performance.Drawing on the conservation of resources theory, we tested the mediating role of employee engagement in the relationship between organizational cronyism and employee performance.We also examined how islamic work ethics moderated the relationship between organizational cronyism and work engagement.The study, with a total of 267 participants, was conducted in the healthcare sector of pakistan.The results revealed that organizational cronyism was negatively related to employee performance.The analyses confirmed the mediating role of work engagement in the relationship between organizational cronyism and employee performance.Similarly, islamic work ethics moderated the relationship between organizational cronyism and work engagement.Implications for future research as well as managerial implications of our findings along with the limitations and future research directions are also discussed.

Journal: Frontiers in psychology (2020)
Publication types: Journal Article
Pharmacokinetics and Toxicities of Oral Docetaxel Formulations Co-Administered with Ritonavir in Phase I Trials.

Introduction docetaxel is widely used as intravenous (iv) chemotherapy.Oral docetaxel is co-administered with the cytochrome p450 3a4 and p-glycoprotein inhibitor ritonavir to increase oral bioavailability.This research explores the relationship between the pharmacokinetics (pk) and toxicity of this novel oral chemotherapy.Methods the patients in two phase i trials were treated with different oral docetaxel formulations in combination with ritonavir in different dose levels, ranging from 20 to 80 mg docetaxel with 100 to 200 mg ritonavir a day.The patients were categorized based on the absence or occurrence of severe treatment-related toxicity (grade ≥3 or any grade leading to treatment alterations).The docetaxel area under the plasma concentration-time curve (auc) and maximum plasma concentration (cmax) were associated with toxicity.Results thirty-four out of 138 patients experienced severe toxicity, most frequently observed as mucositis, fatigue, diarrhea, nausea and vomiting.The severe toxicity group had a significantly higher docetaxel auc (2231 ± 1405 vs 1011 ± 830 ng/m l*h, p<0.0001) and cmax(218 ± 178 vs 119 ± 77 ng/m l, p<0.0001) as compared to the patients without severe toxicity.When extrapolated from iv pk data, the patients without severe toxicity had a similar cumulative docetaxel auc as with standard 3-weekly iv docetaxel, while the cmaxwas up to 10-fold lower with oral docetaxel and ritonavir.Conclusion severe toxicity was observed in 25% of the patients treated with oral docetaxel and ritonavir.This toxicity seems related to the pk, as the docetaxel auc0-infand cmaxwere up to twofold higher in the severe toxicity group as compared to the non-severe toxicity group.Future randomized trials will provide a further evaluation of the toxicity and efficacy of the new weekly oral docetaxel and ritonavir regimen in comparison to standard iv docetaxel.

Journal: Clinical pharmacology : advances and applications (2021)
Publication types: Journal Article
Plastid RNA editing reduction accompanied with genetic variations inCymbidium, a genus with diverse lifestyle modes.

Recent sequencing efforts have broadly uncovered the evolutionary trajectory of plastid genomes (plastomes) of flowering plants in diverse habitats, yet our knowledge of the evolution of plastid posttranscriptional modifications is limited.In this study, we generated 11 complete plastomes and performed ultra-deep transcriptome sequencing to investigate the co-evolution of plastid rna editing and genetic variation in cymbidium, a genus with diverse trophic lifestyles.Genome size and gene content is reduced in terrestrial and green mycoheterotrophic orchids relative to their epiphytic relatives.This could be partly due to extensive losses and pseudogenization ofndhgenes for the plastid nadh dehydrogenase-like complex, but independent pseudogenization ofndhgenes has also occurred in the epiphyte c.Mannii, which was reported to use strong crassulacean acid metabolism photosynthesis.Rna editing sites are abundant but variable in number among cymbidiumplastomes.The nearly twofold variation in editing abundance is mainly due to extensive reduction of ancestral editing sites inndhtranscripts of terrestrial, mycoheterotrophic, and c.Manniiplastomes.The co-occurrence of editing reduction and pseudogenization inndhgenes suggests functional constraints on editing machinery may be relaxed, leading to nonrandom loss of ancestral edited sites via reduced editing efficiency.This study represents the first systematic examination of rna editing evolution linked to plastid genome variation in a single genus.We also propose an explanation for how genomic and posttranscriptional variations might be affected by lifestyle-associated ecological adaptation strategies in cymbidium.

Journal: Plant diversity (2022)
Publication types: Journal Article
Implementation of core elements of antibiotic stewardship in nursing homes-National Healthcare Safety Network, 2016-2018.

To assess the national uptake of the centers for disease control and prevention's (cdc) core elements of antibiotic stewardship in nursing homes from 2016 to 2018 and the effect of infection prevention and control (ipc) hours on the implementation of the core elements.Design retrospective, repeated cross-sectional analysis.Setting us nursing homes.Methods we used the national healthcare safety network (nhsn) long-term care facility component annual surveys from 2016 to 2018 to assess nursing home characteristics and percent implementation of the core elements.We used log-binomial regression models to estimate the association between weekly ipc hours and the implementation of all 7 core elements while controlling for confounding by facility characteristics.Results we included 7,506 surveys from 2016 to 2018.In 2018, 71% of nursing homes reported implementation of all 7 core elements, a 28% increase from 2016.The greatest increases in implementation from 2016 to 2018 were in education (19%), reporting (18%), and drug expertise (15%).In 2018, 71% of nursing homes reported pharmacist involvement in improving antibiotic use, an increase of 27% since 2016.Nursing homes that reported at least 20 hours of ipc activity per week were 14% (95% confidence interval, 7%-20%) more likely to implement all 7 core elements when controlling for facility ownership and affiliation.Conclusions nursing homes reported substantial progress in antibiotic stewardship implementation from 2016 to 2018.Improvements in access to drug expertise, education, and reporting antibiotic use may reflect increased stewardship awareness and resource use among nursing home providers under new regulatory requirements.Nursing home stewardship programs may benefit from increased ipc staff hours.

Journal: Infection control and hospital epidemiology (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, P.H.S.