syedzayyan/paper_mill_benchmark huggingface dataset:
The NanoInformatics Knowledge Commons: Capturing spatial and temporal nanomaterial transformations in diverse systems.

The empirical necessity for integrating informatics throughout the experimental process has become a focal point of the nano-community as we work in parallel to converge efforts for making nano-data reproducible and accessible.The nano informatics knowledge commons (nikc) database was designed to capture the complex relationship between nanomaterials and their environments over time in the concept of an 'instance'.Our instance organizational structure (ios) was built to record metadata on nanomaterial transformations in an organizational structure permitting readily accessible data for broader scientific inquiry.By transforming published and on-going data into the ios we are able to tell the full transformational journey of a nanomaterial within its experimental life cycle.The ios structure has prepared curated data to be fully analyzed to uncover relationships between observable phenomenon and medium or nanomaterial characteristics.Essential to building the nikc database and associated applications was incorporating the researcher's needs into every level of development.We started by centering the research question, the query, and the necessary data needed to support the question and query.The process used to create nanoinformatic tools informs usability and analytical capability.In this paper we present the nikc database, our developmental process, and its curated contents.We also present the collaboration tool which was built to foster building new collaboration teams.Through these efforts we aim to: 1) elucidate the general principles that determine nanomaterial behavior in the environment; 2) identify metadata necessary to predict exposure potential and bio-uptake; and 3) identify key characterization assays that predict outcomes of interest.

Journal: NanoImpact (2021)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.;Research Support, Non-U.S. Gov't
Advance Care Planning, Shared Decision Making, and Serious Illness Conversations in Onconephrology.

Advance care planning, shared decision making, and serious illness conversations are communication processes designed to promote patient-centered care.In onconephrology, patients face a series of complex medical decisions regarding their care at the intersection of oncology and nephrology.Clinicians who aim to ensure that patient preferences and values are integrated into treatment planning must work within a similarly complex care team comprising multiple disciplines.In this review, we describe key decision points in a patient's care trajectory, as well as guidance on how and when to engage in advance care planning, shared decision making, and serious illness discussions.Further research on these processes in the complex context of onconephrology is needed.

Journal: Seminars in nephrology (2022)
Publication types: Journal Article;Review
Factors that Affect the Frequency of HIV Testing in College Men Who Have Sex with Men - Northeast China, 2017-2018.

What is already known about this topic?Human immunodeficiency virus (hiv) testing is a critical tool in reducing hiv transmission among men who have sex with men (msm); young msm frequently use mobile phone applications and participate in social hook-ups.What is added by this report?The prevalence of hiv testing-frequency (≥2) over the whole study period (15 months) was 38.6% among college msm in northeast china.Msm with more social contacts, recreational drug use, and prior hiv self-test experience (reported via mobile phone geo-social apps) were more likely to have higher offline hiv testing frequency.What are the implications for public health practice?A gay-oriented app provides opportunities for online interventions to promote hiv testing services.

Journal: China CDC weekly (2022)
Publication types: Journal Article
Delusion of pregnancy: Conception in brain.

Delusional disorders are common psychiatric disorders, but a delusion of pregnancy is a rare condition.Four cases that presented at a single tertiary care psychiatry center with delusion of pregnancy as a part of different psychological disorders are illustrated here.These cases were seen over a period of 6 months and had varied presentations and associated psychopathologies.Three of the four patients showed rapid recovery to treatment, but one patient was lost to follow-up.The heterogeneity in the presentation, sociodemographic profile of the patients and even in the symptom profile and response to treatment in this condition is highlighted and discussed in this case series.

Journal: Industrial psychiatry journal (2022)
Publication types: Case Reports;Journal Article
Development of an Assessment Tool of Menstrual-Cycle-Related Signs and Symptoms Based on Thai Traditional Medicine Principles for Evaluation of Women's Health.

Utilization of thai traditional medicine (ttm) was considered in menstrual-cycle-related signs and symptoms (mcss) to evaluate women's health.Ttm clinicians diagnosed the mcss by signs, symptoms, and associated factors of patients including a physical examination to find patterns of imbalance elements and the origin of the disorder to optimize treatment.Thus, the purpose of this study was to develop a new assessment tool, the menstrual-cycle-related signs and symptoms questionnaire (mcsq) based on ttm principles for evaluation of women's menstrual health.Methods the items and components of the mcsq were adjusted by ttm expert consensus using the delphi technique.The content validity of the mcsq was quantified by the content validity index (cvi).Mcsq were examined by construct validity and internal consistency reliability using exploratory factor analysis (efa) and cronbach'sαcoefficient, respectively.Results : all 19 experts (100%) responded to the questionnaires in the three rounds of the delphi technique.The mcsq showed high content validity of individual items (i-cvi = 0.83-1.00) and high overall content validity of the questionnaire (s-cvi/ave = 0.98).Overall, 429 of 432 participants completed the questionnaire (99.31%).After factor analysis, the final mcsq was divided into two sections, which consisted of 49 items.The first had 23 items focusing on the mcss.And, the second had 14 items of personal and medical data including 12 items of associated factors.Cronbach'sαcoefficient of the final mcsq was 0.87, and that of each component was between 0.32 and 0.82.Conclusions this study reports a new mcs questionnaire tool, which was developed from ttm knowledge to evaluate women's health.This questionnaire showed an acceptable level of validity and reliability.Thus, it is also expected to be useful in clinical practice and ongoing research on evaluation of women's health.

Journal: Evidence-based complementary and alternative medicine : eCAM (2021)
Publication types: Journal Article
Toward an understanding of allogeneic conflict in pregnancy and transplantation.

Pregnancy is recognized as a spontaneously acquired state of immunological tolerance by the mother to her semi-allogeneic fetus, but it is a major cause of allosensitization in candidates for organ transplantation.This sensitization, assessed by the presence of anti-hla ig g, contributes to sex disparity in access to transplantation and increases the risk for rejection and graft loss.Understanding this dual tolerance/sensitization conundrum may lead to new strategies for equalizing access to transplantation among sexes and improving transplant outcomes in parous women.Here, we review the clinical evidence that pregnancy results in humoral sensitization and query whether t cell responses are sensitized.Furthermore, we summarize preclinical evidence on the effects of pregnancy on fetus-specific cd4+ conventional, regulatory, and cd8+ t cells, and humoral responses.We end with a discussion on the impact of the divergent effects that pregnancy has upon alloantigen re-encounter in the context of solid organ transplantation, and how these insights point to a therapeutic roadmap for controlling pregnancy-dependent allosensitization.

Journal: The Journal of experimental medicine (2022)
Publication types: Journal Article;Review;Research Support, N.I.H., Extramural
Nuances of Responses to Two Sources of Grapevine Leafroll Disease on Pinot Noir Grown in the Field for 17 Years.

Grapevine leafroll disease (gld) is one of the most economically damaging virus diseases in grapevine, with grapevine leafroll-associated virus 1 (glra v-1) and grapevine leafroll-associated virus 3 (glra v-3) as the main contributors.This study complements a previously published transcriptomic analysis and compared the impact of two different forms of gld to a symptomless control treatment: a mildly symptomatic form infected with glra v-1 and a severe form with exceptionally early leafroll symptoms (up to six weeks before veraison) infected with glra v-1 and glra v-3.Vine physiology and fruit composition in 17-year-old pinot noir vines were measured and a gradient of vigor, yield, and berry quality (sugar content and berry weight) was observed between treatments.Virome composition, confirmed by individual rt-pcr, was compared with biological indexing.Three divergent viromes were recovered, containing between four to seven viruses and two viroids.They included the first detection of grapevine asteroid mosaic-associated virus in switzerland.This virus did not cause obvious symptoms on the indicators used in biological indexing.Moreover, the presence of grapevine virus b (gvb) did not cause the expected corky bark symptoms on the indicators, thus underlining the important limitations of the biological indexing.Transmission of glra v-3 alone or in combination with gvb by planococcus comstockimealybug did not reproduce the strong symptoms observed on the donor plant infected with a severe form of gld.This result raises questions about the contribution of each virus to the symptomatology of the plant.

Journal: Viruses (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Assessing Aerated Vermicompost Tea Combined with Microbial Biological Control Agents for Suppression ofFusariumandRhizoctonia.

Biological control of plant diseases is important in organic greenhouse vegetable production, where fungicide use is limited.Organic producers use microbially diverse substrates, including composts, as media for plant growth.Previous research into the impact of vermicompost on the efficacy of applied biocontrol agents is limited.An in vitro assay was developed to test the efficacy of two biological control agents in a competitive microbial background.Suppression of the pathogen fusarium oxysporumf.Sp.radicis-cucumerinumby clonostachys roseaf.catenulata(gliocladium catenulatumstrain j1446 [prestop]) and bacillus subtilisstrain qst 713 (rhapsody), was assessed on agar media amended with aerated vermicompost tea (act).Pathogen growth was reduced more by c.Roseathan act alone, and c.Roseawas equally effective when combined with act.In contrast,b.Subtilisreduced pathogen growth less than act and, when combined, reduced pathogen growth no more than act alone.Both biocontrol agents were similarly tested with act against f.Oxysporumf.Sp.radicis-cucumerinumand rhizoctonia solanion cucumber and radish.Additive, neutral, and antagonistic responses, depending on host, pathogen, and biocontrol agent, were observed.Act alone provided more consistent disease suppression on cucumber compared with b.Subtilisor c.Rosea.In combination, disease suppression was most often better than each biocontrol alone but not better than act alone.Act had antagonistic or additive interactions with c.Roseain the radish/r.Solanipathosystem, depending on the experiment.The specific and general suppression of plant diseases by biological control agents in microbially rich environments is variable and warrants further study.

Journal: Phytopathology (2021)
Publication types: Journal Article
Recent Update on Neonatal Resuscitation.

Every 5 y, the international liaison committee on resuscitation publishes consensus on cardiopulmonary resuscitation, and emergency cardiovascular science and treatment recommendations.The latest update on neonatal resuscitation guidelines was published in 2020.Here, the authors review the important changes in the recent recommendations, including initial steps of resuscitation, umbilical cord management, management of nonvigorous infants born through meconium-stained amniotic fluid, sustained inflation in preterm infants, epinephrine, vascular access, timing of discontinuation of resuscitative effort, and team briefing and debriefing.

Journal: Indian journal of pediatrics (2022)
Publication types: Journal Article;Review
Bismuth chelation for targeted alpha therapy: Current state of the art.

Current interest in the α-emitting bismuth radionuclides, bismuth-212 (212bi) and bismuth-213 (213bi), stems from their great potential for targeted alpha therapy (tat), an expanding and promising approach for the treatment of micrometastatic disease and the eradication of single malignant cells.To selectively deliver their emission to the cancer cells, these radiometals must be firmly coordinated by a bifunctional chelator (bfc) attached to a tumour-seeking vector.This review provides a comprehensive overview of the current state-of-the-art chelating agents for bismuth radioisotopes.Several aspects are reported, from their 'cold' chelation chemistry (thermodynamic, kinetic, and structural properties) and radiolabelling investigations to the preclinical and clinical studies performed with a variety of bioconjugates.The aim of this review is to provide both a guide for the rational design of novel optimal platforms for the chelation of these attractive α-emitters and emphasize the prospects of the most encouraging chelating agents proposed so far.

Journal: Nuclear medicine and biology (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't
Trends and predictors of 30-day readmissions in subjects with eosinophilic esophagitis: results from a national cohort.

Eosinophilic esophagitis (eo e) is a chronic allergic inflammatory condition causing recurrent dysphagia and may predispose patients to repeated hospitalizations.We assessed temporal trends and factors affecting readmissions in patients with eo e.Methods patients with primary diagnosis of eo e and/or a complication (dysphagia, weight loss, and esophageal perforation) from eo e between 2010 and 2017 were identified from the national readmissions database using the international classification of diseases codes.The primary outcome was incidence of eo e related 30-day readmission.Independent risk factors for readmissions were evaluated using multivariable logistic regression analysis.Secondary outcomes were temporal trends of readmissions and healthcare costs.Results of the 2,676 (mean age 45 ± 17.8 years, 1,667 males) index adult admissions, 2,103 (79%) patients underwent an upper endoscopy during the admission.The mean length of stay (los) was 3 ± 3.7 days.The 30-day readmission rate was steady at 6.8% from 2010 to 2017 and majority of the readmissions occurred by day 10 of index discharge.Age > 70 years was associated with a higher trend in 30-day readmission (p < 0.001).Longer los, history of smoking and the presence of eosinophilic gastroenteritis predicted readmission.Conversely, a history of foreign body impaction and upper endoscopy (including esophageal dilation) at index admission were negatively associated with readmission.Mean hospital charges significantly increased from $24,783 in 2010 to $40,922 in 2017.Conclusion readmissions due to eo e are more likely to occur in the first 10 days of discharge and at a lesser rate when upper endoscopies are performed at the index admission.

Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus (2022)
Publication types: Journal Article
The association of breakfast skipping and television viewing at breakfast with weight status among parents of 10-12-year-olds in eight European countries; the ENERGY (EuropeaN Energy balance Research to prevent excessive weight Gain among Youth) cross-sectional study.

The main objective was to assess the relationship of breakfast skipping, television (tv) viewing at breakfast and breakfast without tv with weight status among parents of 10-12-year-olds in eight european countries.Design a cross-sectional survey assessed breakfast eating and tv viewing at breakfast by three frequency questions and parents were categorized into: (i) breakfast skippers; (ii) breakfast with tv (tv watchers at breakfast); and (iii) breakfast without tv (breakfast eaters who do not watch tv during breakfast).Self-reported weight and height were used to categorize weight status as underweight, normal weight, overweight and obese.Multinomial logistic regression analyses were conducted with weight status as the dependent variable and breakfast habits as predictors, adjusting for sex, ethnicity and level of education.Setting the survey was conducted in 2010 in 199 primary schools across eight european countries participating in the energy (europea n energy balance research to prevent excessive weight gain among youth) cross-sectional study.Subjects parents (n 6512) of 10-12-year-olds responded to the questionnaire.Results in the total study sample, with breakfast without tv as the reference group and adjusting for sex, ethnicity and level of education, the or of being respectively overweight or obese (compared with normal weight) was 1.2 (95% ci 1.0, 1.4) or 1.8 (95% ci 1.5, 2.3) for breakfast skippers.The or of being respectively underweight or obese was 0.5 (95% ci 0.2, 0.9) or 1.4 (95% ci 1.1, 1.8) for breakfast with tv.Conclusions breakfast skippers were significantly more likely to be overweight and obese, and those eating breakfast while watching tv were significantly more likely to be obese and less likely to be underweight.

Journal: Public health nutrition (2014)
Publication types: Journal Article;Multicenter Study;Research Support, Non-U.S. Gov't
Beyond the canonical role of TFIIB in eukaryotic transcription.

The role of general transcription factor tfiib in transcription extends well beyond its evolutionarily conserved function in initiation.Chromatin localization studies demonstrating binding of tfiib to both the 5' and 3' ends of genes in a diverse set of eukaryotes strongly suggested a rather unexpected role of the factor in termination.Tfiib indeed plays a role in termination of transcription.Tfiib occupancy of the 3' end is possibly due to its interaction with the termination factors residing there.Interaction of the promoter-bound tfiib with factors occupying the 3' end of a gene may be the basis of transcription-dependent gene looping.The proximity of the terminator-bound factors with the promoter in a gene loop has the potential to terminate promoter-initiated upstream anti-sense transcription thereby conferring promoter directionality.Tfiib, therefore, is emerging as a factor with pleiotropic roles in the transcription cycle.This could be the reason for preferential targeting of tfiib by viruses.Further studies are needed to understand the critical role of tfiib in viral pathogenesis in the context of its newly identified roles in termination, gene looping and promoter directionality.

Journal: Current genetics (2022)
Publication types: Journal Article;Review
Learnings from a successful transformation to a high-performance organization: a longitudinal case study.

An increasing number of organizations embark on a journey to transform themselves into a high-performance organization (hpo) to be able to better deal with the changes in their environment.Unfortunately, in the current literature hardly any approaches are described that can support them during this transformation.One promising approach, the (waal and heijtel, meas bus excell 21:101-116, 2017) hpo transformation approach, has only been validated in one instance.This study outlines an additional validated approach.A simplified version of the aforementioned transformation approach (waal et al.The high-performance finance function, handbook for the future-oriented financial professional, igi global, hershey, 2022) was used at a case company which in 5 year time transformed into an hpo.Based on a questionnaire which collected and evaluated interventions undertaken by the case company, coupled with an extensive interview on the interventions with the manager of the case company, the interventions were categorized in the hpo transformation approach.The hpo transformation approach made it possible to make a structured overview of the interventions, which gave insight into how the case company went about its successful hpo transformation.Thus, the research has both a theoretical and practical contribution.Theoretically, the currently rather limited academic literature on transformation approaches regarding high-performance organizations is extended with another validated case, thus further developing this line of research.Practically, organizations get access to a validated transformation approach, thereby increasing their chance on a successful hpo transformation.Supplementary information the online version contains supplementary material available at .

Journal: SN business & economics (2022)
Publication types: Journal Article
Crop Sorghum Ensiled With Unsalable Vegetables Increases Silage Microbial Diversity.

Ensiling vegetables with forage crops is a suggested method of waste diversion and can be directly utilized as a livestock feed.Carrot or pumpkin, ensiled at 0, 20, or 40% dry matter (dm) with crop sorghum, and with or without a second-generation silage inoculant were assessed for nutritive composition, organic acid profiles, aerobic stability andin vitrorumen fermentation characteristics.The study was a completely randomized design, with the fixed effects consisting of vegetable type (carrot vs.Pumpkin), level (i.e., the level of vegetables), inoculant (inoculant or non-inoculant) and the interactions, and mini-silos within treatment as the random effect.The experimental unit for sorghum treatments represented by each mini-silo (5 kg capacity).Silage was sampled after 70-days ensiling for nutrient composition, 14-day aerobic stability, organic acid profiles and microbial diversity.After 24 hin vitroincubation, rumen fermentation parameters were assessed, measuring gas and methane (ch4) production,in vitrodigestibility and volatile fatty acid concentrations.Sorghum ensiled with carrot or pumpkin at 20% or 40% dm increased crude fat (p≤ 0.01) and decreased (p≤ 0.01) silage surface temperature upon aerobic exposure compared to the control.Bacterial communities analyzed through 16s r rna gene sequencing linearly increased (p≤ 0.01) in diversity across both vegetables when the vegetable proportion was increased in the silage; dominated by lactobacillusspecies.Its analysis of the fungal microbiota upon silage opening and after 14 days (aerobic stability) identified increased (p≤ 0.03) fungal diversity with increasing vegetable proportions, predominantly populated by fusarium denticulatum,issatchenkia orientalis,kazachstania humilis, and monascus purpureus.Upon assessmentin vitro, there was an increase (p≤ 0.04) inin vitrodigestibility and some ch4parameters (% ch4, and mg ch4/g dm), with no effect (p≥ 0.17) on remaining ch4parameters (m l ch4/g dm, mg ch4/g digested dm), gas production or p h.However, increasing vegetable amount decreased percentage of acetic acid and increased percentage of propionic acid of the total vfa, decreasing a:p ratio and total vfa concentration as a result (p≤ 0.01).The results from this study indicate including carrot or pumpkin at 20 or 40% dm in a sorghum silage can produce a highly digestible, microbially diverse and energy-rich livestock feed.

Journal: Frontiers in microbiology (2019)
Publication types: Journal Article