syedzayyan/paper_mill_benchmark huggingface dataset:
Clinical management of vascular lake during transarterial chemoembolization with CalliSpheres drug-eluting beads (DEBs) for the treatment of hepatocellular carcinoma.

To summarize the incidence and management strategy of vascular lake (vl) during the treatment of hepatocellular carcinoma (hcc) using transarterial chemoembolization (tace) with calli spheres drug-eluting beads (debs), and to analyze its relationship with tumor response rate (rr).The etiology and clinical significance of vl were also analyzed based on the available literature.Methods the clinical data of 92 hcc patients who were treated with chemoembolization using calli spheres debs (deb-tace) in two centers were retrospectively analyzed.All 92 patients were treatment-naïve and treated by deb-tace.The incidence of vl and its clinical treatment during the first embolization session were summarized.The lesions were divided into a vl group and a non-vl group to analyze the relationship between vl and tumor rr.Results the embolization was successful in 98.9% of patients (91/92).A total of 33 vls (18.4%; including 15 stable and 18 unstable vls) were found among the 179 nodules treated.The unstable vls were further embolized with embolic agent.One patient with unstable vl developed bleeding due to hepatic rupture and died.During the follow-up, residual tumors were found around 2 stable vls, 2 lesions in 2 patients were treated with ct-guided radiofrequency ablation.The tumor rr was 84.4% in vl group, which was significantly higher than that (58.9%) in the non-vl group (p=0.007).Conclusions vl is a unique phenomenon during deb-tace.It may be accompanied by residual tumors and bleeding due to rupture.Therefore, vl should be cautiously managed in clinical practice.

Journal: Translational cancer research (2020)
Publication types: Journal Article
Bio-enabling strategies to mitigate the pharmaceutical food effect: A mini review.

The concomitant administration of oral drugs with food can result in significant changes in bioavailability, leading to variable pharmacokinetics and considerable clinical implications, such as over- or under-dosing.Consequently, there is increasing demand for bio-enabling formulation strategies to reduce variability in exposure between the fasted and fed state and/or mitigate the pharmaceutical food effect.The current review critically evaluates technologies that have been implemented to overcome the positive food effects of pharmaceutical drugs, including, lipid-based formulations, nanosized drug preparations, cyclodextrins, amorphisation and solid dispersions, prodrugs and salts.Additionally, improved insight into preclinical models for predicting the food effect is provided.Despite the wealth of research, this review demonstrates that application of optimal formulation strategies to mitigate the positive food effects and the evaluation in preclinical models is not a universal approach, and improved standardisation of models to predict the food effects would be desirable.Ultimately, the successful reformulation of specific drugs to eliminate the food effect provides a panoply of advantages for patients with regard to clinical efficacy and compliance.

Journal: International journal of pharmaceutics (2022)
Publication types: Journal Article;Review
Size-Selective Suzuki-Miyaura Coupling Reaction over Ultrafine Pd Nanocatalysts in a Water-Stable Indium-Organic Framework.

Metal nanoparticles stabilized by crystalline metal-organic frameworks (mofs) are highly promising for green heterogeneous catalysis.In this work,in situformed ultrafine pd nanocatalysts with an average size of 3.14 nm have been successfully immobilized into the mesopores or defects of a water-stable indium-based mof by the double-solvent method and subsequent reduction.Significantly, the obtained pd@in of-1 displays an obvious and satisfactory size-selective effect in the suzuki-miyaura coupling reaction between arylboronic acids and aryl bromides.On the basis of the synergistic effect, microporous in of-1 nanorods afford a confined space for improving the selectivity of target products while pd nanoparticles endow abundant active sites for catalysis.Herein, choosing the smallest size reactant with only one benzene ring gives the highest isolated yield of 90%, and if the size is larger, the yield is obviously reduced or even the target product could not be collected.Looking forward, this demonstrated study not only assembles a well-designed pd@mof composite with unique micro-nanostructures but also delivers an impressive option for cross-coupling reaction, which has implications for the further development of mof hybrids for sustainable applications.

Journal: Inorganic chemistry (2022)
Publication types: Journal Article
Occurrence and mass flows of contaminants of emerging concern (CECs) in Sweden's three largest lakes and associated rivers.

Contaminants of emerging concern (cecs) are a concern in aquatic environments due to possible adverse effects on the environment and humans.This study assessed the occurrence and mass flows of cecs in sweden's three largest lakes and 24 associated rivers.The occurrence and distribution of 105 cecs was investigated, comprising 71 pharmaceuticals, 13 perfluoroalkyl substances (pfass), eight industrial chemicals, four personal care products (pcps), three parabens, two pesticides, and four other cecs (mostly anthropogenic markers).This is the first systematic study of cecs in sweden's main lakes and one of the first to report environmental concentrations of the industrial chemicals tributyl citrate acetate and 2,2'-dimorpholinyldiethyl-ether.The ∑cec concentration was generally higher in river water (31-5200 ng/l; median 440 ng/l) than in lake water (36-900 ng/l; median 190 ng/l).At urban lake sites, seasonal variations were observed for pcps and parabens, and also for antihistamines, antidiabetics, antineoplastic agents, antibiotics, and fungicides.The median mass cec load in river water was 180 g/day (range 4.0-4300 g/day), with a total mass load of 5000 g/day to lake vänern, 510 g/day to lake vättern, and 5600 g/day to lake mälaren.All three lakes are used as drinking water reservoirs, so further investigations of the impact of cecs on the ecosystem and human health are needed.

Journal: Chemosphere (2022)
Publication types: Journal Article
Comparison of Efficacy of Different Surgical Techniques for Benign Prostatic Obstruction.

We compared success rates of 3 surgical techniques (holmium laser enucleation of the prostate [ho lep], transurethral resection of the prostate [turp], and photoselective laser vaporization prostatectomy [pvp]) for treatment of benign prostatic obstruction (bpo).We aimed to identify preoperative clinical variables and urodynamic parameters that predict surgical success.Methods a total of 483 patients who underwent surgical treatment for bpo at samsung medical center between 2006 and 2017 were retrospectively analyzed; of these 361, 81, and 41 patients underwent ho lep, turp, and pvp, respectively.Prostate-specific antigen, prostate volume, urodynamic parameters, and international prostate symptom score (ipss)/quality of life (qo l) index were evaluated preoperatively; uroflowmetry, postvoid residual urine, and ipss/qo l index were measured 6 months postoperatively.Surgical success was defined based on ipss, maximum flow rate, and qo l index and predictive factors were identified using multiple logistic regression analyses.Results success rates of ho lep, turp, and pvp were 67.6%, 65.4%, and 34.1%, respectively, and the ho lep and turp groups were not significantly different.Regression analysis revealed prostate volume ≥50 m l and bladder outlet obstruction index (booi) ≥40 to be independent factors predicting ho lep success.Only high preoperative qo l could predict the success of turp, whereas other urodynamic parameters remained unrelated.Conclusion patients treated with ho lep and turp displayed equivalent efficacies, but pvp was relatively less efficient than both.Preoperative variables of prostate volume ≥50 m l and booi ≥40 were independent predictive factors for the success of ho lep but not of turp.

Journal: International neurourology journal (2021)
Publication types: Journal Article
High spatiotemporal resolution dynamic contrast-enhanced MRI improves the image-based discrimination of histopathology risk groups of peripheral zone prostate cancer: a supervised machine learning approach.

To assess if adding perfusion information from dynamic contrast-enhanced (dce mri) acquisition schemes with high spatiotemporal resolution to t2w/dwi sequences as input features for a gradient boosting machine (gbm) machine learning (ml) classifier could better classify prostate cancer (pca) risk groups than t2w/dwi sequences alone.Materials and methods one hundred ninety patients (68 ± 9 years) were retrospectively evaluated at 3t mri for clinical suspicion of pca.Included were 201 peripheral zone (pz) pca lesions.Histopathological confirmation on fusion biopsy was matched with normal prostate parenchyma contralaterally.Biopsy results were grouped into benign tissue and low-, intermediate-, and high-risk groups (gleason sum score 6, 7, and > 7, respectively).Dce mri was performed using golden-angle radial sparse mri.Perfusion maps (ktrans, kep, ve), apparent diffusion coefficient (adc), and absolute t2w signal intensity were determined and used as input features for building two ml models: gbm with/without perfusion maps.Areas under the receiver operating characteristic curve (auc) values for correlated models were compared.Results for the classification of benign vs.Malignant and intermediate- vs.High-grade pca, perfusion information added relevant information (auc values 1 vs.0.953 and 0.909 vs.0.700, p < 0.001 and p = 0.038), while no statistically significant effect was found for low- vs.Intermediate- and high-grade pca.Conclusion perfusion information from dce mri acquisition schemes with high spatiotemporal resolution to ml classifiers enables a superior risk stratification between benign and malignant and intermediate- and high-risk pca in the pz compared with classifiers based on t2w/dwi information alone.Key points • in the recent guidelines, the role of dce mri has changed from a mandatory to recommended sequence.• dce mri acquisition schemes with high spatiotemporal resolution (e.g., grasp) have been shown to improve the diagnostic performance compared with conventional dce mri sequences.• using perfusion information acquired with grasp in combination with ml classifiers significantly improved the prediction of benign vs.Malignant and intermediate- vs.High-grade peripheral zone prostate cancer compared with non-contrast sequences.

Journal: European radiology (2020)
Publication types: Journal Article
Dexmedetomidine use in the ED for control of methamphetamine-induced agitation.

Chemical restraint is often required to control agitation induced by methamphetamine.Dexmedetomidine is an α-2 adrenergic receptor agonist with sedative, analgesic, and sympatholytic properties.Its use in the emergency department (ed) to control methamphetamine-induced agitation has not been reported.Objective to report two cases of methamphetamine-induced agitation successfully sedated with dexmedetomidine in the ed.Case report the first case was a 42-year-old man with unstable emotion and violent behaviours after smoking methamphetamine.His agitation did not respond to a large cumulative dose of benzodiazepines (10mg of diazepam and 332mg of midazolam) administered over 48h and sedation was achieved with dexmedetomidine.The second case was a 38-year-old methamphetamine user with unstable emotion and recurrent episodes of agitation despite repeated doses of benzodiazepines, whose agitation was controlled with dexmedetomidine infusion.Discussion in both cases, dexmedetomidine apparently reduced the dose of benzodiazepines needed to achieve adequate sedation.Transient falls in blood pressure and slowing of the heart rate were noted, which resolved either spontaneously or after reducing the infusion rate without requiring drug treatment.Conclusion dexmedetomidine can be considered as an adjunct for chemical restraint when standard treatment fails to control the agitation induced by methamphetamine, but patient's hemodynamic state should be monitored closely during administration.Its efficacy and safety in the ed warrant further evaluation with prospective controlled trials.

Journal: The American journal of emergency medicine (2017)
Publication types: Case Reports;Journal Article
Emergence of complex dynamics of choice due to repeated exposures to extinction learning.

Extinction learning, the process of ceasing an acquired behavior in response to altered reinforcement contingencies, is not only essential for survival in a changing environment, but also plays a fundamental role in the treatment of pathological behaviors.During therapy and other forms of training involving extinction, subjects are typically exposed to several sessions with a similar structure.The effects of this repeated exposure are not well understood.Here, we studied the behavior of pigeons across several sessions of a discrimination-learning task in context a, extinction in context b, and a return to context a to test the context-dependent return of the learned responses (aba renewal).By focusing on individual learning curves across animals, we uncovered a session-dependent variability of behavior: (1) during extinction, pigeons preferred the unrewarded alternative choice in one-third of the sessions, predominantly during the first one.(2) in later sessions, abrupt transitions of behavior at the onset of context b emerged, and (3) the renewal effect decayed as sessions progressed.We show that the observed results can be parsimoniously accounted for by a computational model based only on associative learning between stimuli and actions.Our work thus demonstrates the critical importance of studying the trial-by-trial dynamics of learning in individual sessions, and the power of "simple" associative learning processes.

Journal: Animal cognition (2021)
Publication types: Journal Article
Whole-genome assembly and analysis of a medicinal fungus:Inonotus hispidus.

Inonotus hispidus(i.Hispidus) is a medicinal macrofungus that plays a key role in anti-tumor and antioxidant functions.To further understand and enhance the value of i.Hispidus, we performed whole-genome sequencing and an analysis of its strain for the first time.i.Hispiduswas sequenced using the illumina nova seq high-throughput sequencing platform.The genome length was 35,688,031 bp and 30 contigs, with an average length of 1,189,601.03 bp.Moreover, database alignment annotated 402 cazyme genes and 93 functional genes involved in regulating secondary metabolites in the i.Hispidusgenome to find the greatest number of genes involved in terpenes in that genome, thus providing a theoretical basis for its medicinal value.Finally, the phylogenetic analysis and comparative genomic analysis of single-copy orthologous protein genes from other fungi in the same family were conducted; it was found that i.Hispidusand sanghuangporus baumiihave high homology.Our results can be used to screen candidate genes for the nutritional utilization of i.Hispidusand the development of high-yielding and high-quality i.Hispidusvia genetic means.

Journal: Frontiers in microbiology (2022)
Publication types: Journal Article
Pharmacogenomics and histone deacetylase inhibitors.

The histone deacetylase inhibitor valproic acid (vpa) has been used for many decades in neurology and psychiatry.The more recent introduction of the histone deacetylase inhibitors (hdis) belinostat, romidepsin and vorinostat for treatment of hematological malignancies indicates the increasing popularity of these agents.Belinostat, romidepsin and vorinostat are metabolized or transported by polymorphic enzymes or drug transporters.Thus, genotype-directed dosing could improve pharmacotherapy by reducing the risk of toxicities or preventing suboptimal treatment.This review provides an overview of clinical studies on the effects of polymorphisms on the pharmacokinetics, efficacy or toxicities of hdis including belinostat, romidepsin, vorinostat, panobinostat, vpa and a number of novel compounds currently being tested in phase i and ii trials.Although pharmacogenomic studies for hdis are scarce, available data indicate that therapy with belinostat (ugt1a1), romidepsin (abcb1), vorinostat (ugt2b17) or vpa (ugt1a6) could be optimized by upfront genotyping.

Journal: Pharmacogenomics (2016)
Publication types: Journal Article;Review
RA-DENet: Reverse Attention and Distractions Elimination Network for polyp segmentation.

To address the problems of polyps of different shapes, sizes, and colors, low-contrast polyps, various noise distractions, and blurred edges on colonoscopy, we propose the reverse attention and distraction elimination network, which includes improved reverse attention, distraction elimination, and feature enhancement.First, we input the images in the polyp image set, and use the five levels polyp features and the global polyp feature extracted from the res2net-based backbone as the input of the improved reverse attention to obtain augmented representations of salient and non-salient regions to capture the different shapes of polyp and distinguish low-contrast polyps from background.Then, the augmented representations of salient and non-salient areas are fed into the distraction elimination to obtain the refined polyp feature without false positive and false negative distractions for eliminating noises.Finally, the extracted low-level polyp feature is used as the input of the feature enhancement to obtain the edge feature for supplementing missing edge information of polyp.The polyp segmentation result is output by connecting the edge feature with the refined polyp feature.The proposed method is evaluated on five polyp datasets and compared with the current polyp segmentation models.Our model improves the m dice to 0.760 on the most challenge dataset (etis).

Journal: Computers in biology and medicine (2023)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Exercise Addiction Stability and Health Effects. A 6-Month Follow-up Postcompetition Study in Amateur Endurance Cyclists.

To study the longitudinal stability of exercise addiction and its health effects in apparently healthy amateur endurance cyclists from pre- to 6-month post-competition.Methods in total, 330 (30 women) adult cyclists were divided into 4 groups based on scores on the exercise addiction inventory at both periods: nonrisk (n=262, 79.1%), transient (n=35, 10.6%), emerging (n=14, 4.2%) and persistent (n=20, 6.1%).Results the prevalence of high-risk exercise addiction was reduced postcompetition (16.7% vs 10.3%, p = 0.017).Of the cyclists with a high precompetition risk of exercise addiction, 63.6% (35/55) had a transient addiction associated with favorable effects on mental quality of life (effect size [es]=0.52, 95% confidence interval: [0.20, 0.86]) and sleep quality (es=-0.50 [-0.89, -0.12]) and avoided the worsening of depression symptom severity compared to the remaining groups (es range=0.51-0.65).The 5.1% (14/275) of cyclists with a precompetition low risk of exercise addiction presented emerging exercise addiction that was associated with a worsened mental quality of life compared to the remaining groups (es ranged 0.59-0.91), sleep quality compared to the nonrisk (es=-0.56 [-0.02, -1.10]) and transient (es=-0.72 [-1.36, -0.08]) groups and anxiety symptom severity compared to the persistent group (es=0.51 [1.20,-0.19]).Conclusions exercise addiction had a marked transitory component at 6-month postcompetition with associated health benefits in amateur endurance cyclists.

Journal: Journal of addiction medicine (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Addressing Public Health Aspects of Cancer Center Catchment Areas.

Serving the catchment area has become an integral mission of cancer centers, and examining the geographic extent of cancer coverage is an important component aimed at efficiently maximizing care and reducing the cancer burden.In addition to cancer incidence and mortality, geographic analyses of cancer center coverage must also be measured by the need for reducing the prevalence of risk factors and increasing screening rates within communities.Here, we briefly comment on these additional parameters and their relevance to analyzing cancer coverage across the united states.See related article by leader et al., p.955.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2022)
Publication types: Editorial;Comment
Cooperative Friendly Jamming Techniques for Drone-Based Mobile Secure Zone.

Threats of eavesdropping and information leakages have increased sharply owing to advancements in wireless communication technology.In particular, the internet of things (io t) has become vulnerable to sniffing or jamming attacks because broadcast communication is usually conducted in open-network environments.Although improved security protocols have been proposed to overcome the limitations of wireless-communication technology and to secure safe communication channels, they are difficult to apply to mobile communication networks and io t because complex hardware is required.Hence, a novel security model with a lighter weight and greater mobility is needed.In this paper, we propose a security model applying cooperative friendly jamming using artificial noise and drone mobility, which are autonomous moving objects, and we demonstrate the prevention of eavesdropping and improved security through simulations and field tests.The cooperative friendly jamming techniques for drone-based mobile secure zone (cfj-dmz) can set a secure zone in a target area to support a safe wireless mobile communication network through friendly jamming, which can effectively reduce eavesdropping threats.According to the experimental results, the average information leakage rate of the eavesdroppers in cfj-dmz-applied scenarios was less than or equal to 3%, an average improvement of 92% over conventional methods.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article
Disposable Electrochemical Sensors for Highly Sensitive Detection of Chlorpromazine in Human Whole Blood Based on the Silica Nanochannel Array Modified Screen-Printed Carbon Electrode.

Rapid and highly sensitive quantitative analysis of chlorpromazine (cpz) in human whole blood is of great importance for human health.Herein, we utilize the screen-printed carbon electrodes (spce) as the electrode substrates for growth of highly electroactive and antifouling nanocomposite materials consisting of vertically ordered mesoporous silica films (vmsf) and electrochemically reduced graphene oxide (er go) nanosheets.The preparation of such vmsf/er go/spce could be performed by using an electrochemical method in a few seconds and the operation is controllable.Inner er go layer converted from graphene oxide (go) in the growth process of vmsf provides oxygen-containing groups and two-dimensional π-conjugated planar structure for stable fabrication of outer vmsf layer.Owing to the π-π enrichment and excellent electrocatalytic abilities of er go, electrostatic preconcentration and antifouling capacities of vmsf, and inherent disposable and miniaturized properties of spce, the proposed vmsf/er go/spce sensor could be applied for quantitative determination of cpz in human whole blood with high accuracy and sensitivity, good stability, and low sample consumption.

Journal: Molecules (Basel, Switzerland) (2022)
Publication types: Journal Article