syedzayyan/paper_mill_benchmark huggingface dataset:
CO2emission accounting and emission reduction analysis of the steel production process based on the material-energy-carbon correlation effect.

This paper develops a process-level carbon emission calculation model for iron and steel enterprises through the carbon emission mechanism of the whole production process.The relationship between material, energy and carbon flows is considered and combined.The carbon emissions of enterprises are divided into industrial emissions and combustion emissions, and the indirect emissions of purchased intermediate products and electricity purchased from the grid are also considered.Carbon emission targets and corresponding emission reduction strategies are formulated at the enterprise and process levels.For example, consider an iron and steel enterprise.The different types of carbon emissions are accounted for, with their reduction potential analysed based on the carbon material flow analysis method.The results show that the carbon emission of this enterprise is 1930.87 kg co2/t (cs), and the combustion emission caused by energy flow is the main contributor to the enterprise's carbon emission, accounting for 57.02% of the total emission.The carbon emission during iron-making accounts for 69.06% of the entire process and is critical in any carbon emission reduction of the enterprise.Among them, process emissions from the blast furnace process account for 81.79% of industrial emissions of the whole process, which is 356.51 kg co2/t (cs), and is the main challenge of low carbon transformation in this extensive process.This study highlights that increasing the integrated steel-making scrap ratio and electric furnace steel production can break through the existing emission reduction limits.A 65.02% carbon emission reduction can be achieved, and using green electricity can reduce emissions by 24.15%.Reasonably determining the amount of purchased coke and paying attention to the high-value recycling of byproduct gas resources in the plant are essential to achieve low-carbon economic development of steel.

Journal: Environmental science and pollution research international (2023)
Publication types: Journal Article
Melanoma Cancer Immunotherapy Using PD-L1 siRNA and Imatinib Promotes Cancer-Immunity Cycle.

Cancer-immunity cycle is a cascade of anticancer immune responses in the body that continues and fights against the cancer expansion.The cancer-immunity cycle is halted by tumor cell immunosuppression of host t cell through programmed cell death receptor 1 (pd-1) and programmed cell death ligand 1 (pd-l1) interactions that induce the functional suppression of tumor-reactive cytotoxic t cells and actively promotes the tumorigenesis via the m tor signaling pathway.Methods here, we demonstrated that this cycle could be enhanced by the synergistic knock down of pd-l1 through co-delivery of si rna-pd-l1 (si pd-l1) and imatinib (imt) in a liposomal nanoparticle.Results the si pdin effectively downregulated the protein expressions of pd-l1 and significantly knocked down the expression of p-s6k protein at in vitro and in vivo conditions which inhibited tumorigenic m tor pathway.The combination-based si pdin exhibited a significantly higher cytotoxic effect compared to that of individual anticancer agents.B16f10 cells treated with si pdin exhibited a significantly higher cancer cell apoptosis (~60%) compared to cocktail combination of si rna+imt (~35%) analyzed by flow cytometer.Importantly, si pdin significantly delayed the tumor growth with significantly lower tumor-specific growth rate than the animals treated with individual free imt or si rna.Si pdin produced a 3-fold higher ifn-γ compared to control in dlns and 4-fold higher ifn-γ in spleens.Conclusion overall, results revealed that the tumors treated with si pdin restored the immunity of ctls by potentially inhibiting the immune checkpoint interactions, suppressed the m tor signaling pathway and exhibited an enhanced anticancer efficacy in melanoma.

Journal: Pharmaceutical research (2020)
Publication types: Journal Article
Detection of Three Sexually Transmitted Infections by Anatomic Site: Evidence From an Internet-Based Screening Program.

Urogenital and rectal specimens collected from the "iwant the kit" internet-based sexually transmitted infection screening program were evaluated for chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis.Of 881 paired specimens submitted from august 2013 to december 2016, 15.0% (n = 132) tested positive for 1 or more sexually transmitted infections, of which 50.8% (n = 67) were identified exclusively through rectal testing.

Journal: Sexually transmitted diseases (2020)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Third-Generation Sequencing: The Spearhead towards the Radical Transformation of Modern Genomics.

Although next-generation sequencing (ngs) technology revolutionized sequencing, offering a tremendous sequencing capacity with groundbreaking depth and accuracy, it continues to demonstrate serious limitations.In the early 2010s, the introduction of a novel set of sequencing methodologies, presented by two platforms, pacific biosciences (pac bio) and oxford nanopore sequencing (ont), gave birth to third-generation sequencing (tgs).The innovative long-read technologies turn genome sequencing into an ease-of-handle procedure by greatly reducing the average time of library construction workflows and simplifying the process of de novo genome assembly due to the generation of long reads.Long sequencing reads produced by both tgs methodologies have already facilitated the decipherment of transcriptional profiling since they enable the identification of full-length transcripts without the need for assembly or the use of sophisticated bioinformatics tools.Long-read technologies have also provided new insights into the field of epitranscriptomics, by allowing the direct detection of rna modifications on native rna molecules.This review highlights the advantageous features of the newly introduced tgs technologies, discusses their limitations and provides an in-depth comparison regarding their scientific background and available protocols as well as their potential utility in research and clinical applications.

Journal: Life (Basel, Switzerland) (2021)
Publication types: Journal Article;Review
Metabolic outcomes in adults with type 2 diabetes and sleep disorders.

Insomnia is frequently co-morbid with obstructive sleep apnea (osa); the effect of insomnia or co-morbid insomnia and osa (osa + i) on associated metabolic outcomes in adults with type 2 diabetes (t2d) remains unclear.This study in adults with t2d compared metabolic outcomes among persons with osa, insomnia, or osa + i.Methods this study analyzed baseline data from the diabetes sleep treatment trial of persons recruited for symptoms of osa or poor sleep quality.Home sleep studies determined osa presence and severity.Insomnia was evaluated using the insomnia severity index.Height and weight to calculate body mass index (bmi) and blood for laboratory values were obtained.Multivariate general linear models were used to examine the impact of the type of sleep disorder and sociodemographic, lifestyle, and sleep risk factors on metabolic outcomes.Results participants (n = 253) were middle-aged (56.3 ± 10.5 years), white (60.5%), obese (mean bmi of 35.3 ± 7.1 kg/m2), and male (51.4%) with poor glucose control (mean hb a1c of 8.0 ± 1.8%).Most participants had osa + i (42.7%) or insomnia only (41.0%).Hb a1c and bmi differed among the sleep disorder groups.In addition, in the adjusted models, having insomnia only, compared to osa only, was associated on average with higher hb a1c levels (b = 1.08 ± 0.40, p < 0.007) and lower bmi (b = - 7.03 ± 1.43, p < 0.001).Conclusions findings suggest that insomnia frequently co-exists with osa, is independently associated with metabolic outcomes in adults with t2d, and should be considered in investigations of the effects of osa in persons with t2d.Trial registration diabetes-obstructive sleep apnea treatment trial (nct01901055), https: clinicaltrials.gov/ct2/show/nct01901055; registration date: july 17, 2013.

Journal: Sleep & breathing = Schlaf & Atmung (2022)
Publication types: Comparative Study;Journal Article
Blosozumab in the treatment of postmenopausal women with osteoporosis: a systematic review and meta-analysis.

Postmenopausal women are one of the most vulnerable groups to osteoporosis.Romosozumab is a newly monoclonal drug that inhibits the activity of sclerostin.Since it has been on the market for only 3 years, there is a lack of systematic analysis on postmenopausal women and the efficacy is not clear.In this study, we compared randomized controlled trials to assess the effects of blosozumab versus placebo in perimenopausal and postmenopausal women.Methods this meta-analysis has been registered in the prospero registry (number crd42020145839).The pub med, cochrane library, clinical key, and embase databases were searched from inception date to july 01, 2021.We used the keywords "osteoporosis", "decreased bone mass", and "blosozumab" to retrieve studies on the relationship between blosozumab and osteoporosis in each database.The inclusion criteria were: (i) randomized controlled trials (rcts) comparing the treatment of osteoporosis with blosozumab and a placebo or without treatment, (ii) studies on postmenopausal women aged over 50 years, and (iii) studies providing bone mineral density data.The quality of all randomized controlled trials included in this study was independently assessed by two researchers according to the cochrane risk manual and was divided into high, medium and low quality.The main results analyzed were bone mineral density (bmd) and t-score.Our results mainly include bmd and procollagen type i n-terminal propeptide (p1np), c-terminal telopeptide of type i collagen (ctx), bone-specific alkaline phosphatase (bsap), and osteocalcin (oc).Results three rcts with 105 patients were selected from 157 retrieved articles.Due to high heterogeneity [bmd: tau2=2.79; chi2=11.70, degrees of freedom (df) =1 (p=0.0006); i2=91%], we could not perform statistical analysis of bmd.The results of bmd were then evaluated systematically.Three rct studies were included in the evaluation.Compared with that of the placebo, blosozumab increased levels of the bmd biomarker osteocalcin [mean deviation (md) 12.55; 95% confidence interval (ci), 8.18, 16.91; p<0.00001].None of the 3 rcts presented a risk of bias during the meta-analysis.Conclusions the results suggested that blosozumab could be used as a target drug to improve bmd in postmenopausal women.This will provide a reference for the clinical treatment of postmenopausal women with osteoporosis.

Journal: Annals of palliative medicine (2022)
Publication types: Meta-Analysis;Systematic Review;Journal Article
Ball milling potassium ferrate activated biochar for efficient chromium and tetracycline decontamination: Insights into activation and adsorption mechanisms.

Herein, novel fe-biochar composites (mbcbm500and mbcbm700) were synthesized through k2fe o4co-pyrolysis and ball milling, and were used to eliminate cr(vi)/tc from water.Characterization results revealed that higher temperature promoted formation of zero-valent iron and fe3c on mbcbm700through carbothermal reduction between k2fe o4and biochar.The higher specific surface area and smaller particle size of mbcbm500/700stemmed from the corrosive functions of k and the ball milling process.And the maximal uptake amount of mbcbm700for cr(vi)/tc was 117.49/90.31 mg/g, relatively higher than that of mbcbm500(93.86/84.15 mg/g).Furthermore, ion exchange, pore filling, precipitation, complexation, reduction and electrostatic attraction were proved to facilitate the adsorption of cr(vi), while hydrogen bonding force, pore filling, complexation and π-π stacking were the primary pathways to eliminate tc.This study provide a reasonable design of fe-carbon materials for cr(vi)/tc contained water remediation, which required neither extra modifiers nor complex preparation process.

Journal: Bioresource technology (2022)
Publication types: Journal Article
Extracolonic tumours in a pedigree with EPCAM-related Lynch Syndrome.

Lynch syndrome is characterized by phenotypic and genotypic heterogeneity.Despite scarce evidence, individuals with an epcam deletion appear to have a comparable risk of colorectal cancer (crc) as msh2 mutation carriers, but a lower risk of extracolonic cancer (such as endometrial cancer) unless the deletion extends close to the promoter of msh2.A genotype-phenotype correlation is yet to be established for epcam alterations.In this report, we describe a family with epcam deletion characterized by a particularly aggressive phenotype and extracolonic cancer.We present a family with 5 members carrying an epcam deletion encompassing exons 8 and 9.Three female family members presented crc at the ages of 32, 44 and 60 (mucinous moderately and well-differentiated adenocarcinoma); in two of them metachronous colon cancers and advanced adenomas were diagnosed in the intensive surveillance program.Two female patients (42 and 63 years-old) presented with gastric cancer (gc).Two patients presented with small bowel cancer at 51 and 60 years-old - the first one presented a metachronous jejunal cancer at 68 years.Only one family member was submitted to hemithyroidectomy due a right-lobe hürthle cell carcinoma at 56 years-old.This report illustrates the existence of intrafamilial clinical heterogeneity among carriers of this epcam alteration, and hence the difficulty in predicting phenotype for epcam-associated lynch syndrome.

Journal: European journal of medical genetics (2022)
Publication types: Journal Article
Australian Perspectives on Opt-In and Opt-Out Consent Systems for Deceased Organ Donation.

Introduction:as many countries change to opt-out systems to address organ shortages, calls for similar reform in australia persist.Community perspectives on consent systems for donation remain under-researched, therefore australian perspectives on consent systems and their effectiveness in increasing donation rates were explored.design:in this descriptive cross-sectional study, participants completed a survey presenting opt-in, soft opt-out, and hard opt-out systems, with corresponding descriptions.Participants chose the system they perceived as most effective and described their reasoning.results:participants (n = 509) designated soft opt-out as the most effective system (52.3%; hard opt-out 33.7%; opt-in 13.7%).Those who identified with an ethnic/cultural group or were not registered had greater odds of choosing opt-out.Six themes identified in thematic analysis reflected their reasoning: (1) who decides (individual, shared decision with family); (2) right to choose; (3) acceptability (ethics, fairness); and utility in overcoming barriers for (4) individuals (apathy, awareness, ease of donating, fear/avoidance of death); (5) family (easier family experience, family veto); (6) society (normalizing donation, donation as default, expanding donor pool).Choice and overcoming individual barriers were more frequently endorsed themes for opt-in and opt-out, respectively.discussion:results suggested the following insights regarding system effectiveness: uphold/prioritize individual's recorded donation decision above family wishes; involve family in decision making if no donation preference is recorded; retain a register enabling opt-in and opt-out for unequivocal decisions and promoting individual control; and maximize ease of registering.Future research should establish whether systems considered effective are also acceptable to the community to address organ shortages.

Journal: Progress in transplantation (Aliso Viejo, Calif.) (2021)
Publication types: Journal Article
Autonomy-supportive exercise behaviors promote breast cancer survivors' well-being.

Grounded in self-determination theory (sdt), this pilot study aimed to test an autonomy-supportive exercise instructing style to promote hedonic (seeking comfort and pleasure) and eudaimonic (seeking to develop the best within one and pursue excellence)orientations, exercise motivation, and psychological well-being of breast cancer survivors.methods:twenty-four breast cancer survivors were randomized in either autonomy-supportive exercise instructing style (treatment condition) or usual exercise instructing style (control condition).The study consisted of a pre-intervention session followed by 22 exercise sessions and a post-intervention session.Hedonic and eudaimonic orientations, exercise motivation, and psychological well-being (subjective vitality) measured at baseline and post-intervention sessions.results:as expected, participants in the treatment condition reported greater eudaimonic and hedonic orientations and subjective vitality compared to the participants in the control condition.The results showed no difference in exercise motivation across conditions.conclusion:we concluded that the sdt-based intervention was successful in helping breast cancer survivors increase hedonic and eudaimonic orientations and subjective vitality.Practical and theoretical implications, along with limitations and future research suggestions are discussed inside.

Journal: Health promotion perspectives (2020)
Publication types: Journal Article
A Case-Control Comparison of Single-Stage Bilateral vs Unilateral Medial Unicompartmental Knee Arthroplasty.

We aimed to compare postoperative pain, functional recovery, and patient satisfaction among patients receiving one-stage medial bilateral or medial unilateral uka (unicompartmental knee arthroplasty).Our main hypothesis was that during the first 72 postoperative hours, patients who underwent medial bilateral uka did not consume more analgesics than those who underwent medial unilateral uka.Methods a prospective case-control study was undertaken involving 148 patients (74 one-stage medial bilateral vs 74 medial unilateral oxford uka).The primary outcome was evaluation of the postoperative total consumption of analgesics from 0 to 72 hours.Next, the postoperative evolution of pain scores and functional recovery were assessed.Oxford knee scores were assessed preoperatively at 6 and 12 months with the occurrence of clinical or radiological complications.Finally, patient satisfaction was evaluated at the final follow-up.Results the cumulative sums of analgesic consumption (0-72 hours) calculated in the morphine equivalent dose were 21.61 ± 3.70 and 19.11 ± 3.12 mg in the patient and control groups, respectively (p = .30).Moreover, there were no significant differences in terms of pain scores (p = .45), functional recovery (p = .59, .34), length of stay (p = .18), oxford knee scores (p = .68, .60), complications (p = .50), patient satisfaction (p = .66), or recommendations for intervention (p = .64).Conclusion patients who undergo one-stage medial bilateral uka do not experience more pain and do not consume more analgesics than those who undergo medial unilateral uka.A bilateral procedure is not associated with a lower recovery or a higher rate of complications, as functional outcomes at 6 and 12 months are similar to those of unilateral management.

Journal: The Journal of arthroplasty (2021)
Publication types: Journal Article
Cation Vacancy in Wide Bandgap III-Nitrides as Single-Photon Emitter: A First-Principles Investigation.

Single-photon sources based on solid-state material are desirable in quantum technologies.However, suitable platforms for single-photon emission are currently limited.Herein, a theoretical approach to design a single-photon emitter based on defects in solid-state material is proposed.Through group theory analysis and hybrid density functional theory calculation, the charge-neutral cation vacancy in iii-v compounds is found to satisfy a unique 5-electron-8-orbital electronic configuration with tdsymmetry, which is possible for single-photon emission.Furthermore, it is confirmed that this type of single-photon emitter only exists in wide bandgap iii-nitrides among all the iii-v compounds.The corresponding photon energy in ga n, al n, and al ga n lies within the optimal range for transfer in optical fiber, thereby render the charge-neutral cation vacancy in wide-bandgap iii-nitrides as a promising single-photon emitter for quantum information applications.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2021)
Publication types: Journal Article
Mesoporous silica particles are phagocytosed by microglia and induce a mild inflammatory responsein vitro.

Mesoporous silica particles (msps) are broadly used drug delivery carriers.In this study, the authors analyzed the responses to msps of astrocytes and microglia, the two main cellular players in neuroinflammation.materials & methods:primary murine cortical mixed glial cultures were treated with rhodamine b-labeled msps.results:msps are avidly internalized by microglial cells and remain inside the cells for at least 14 days.Despite this, msps do not affect glial cell viability or morphology, basal metabolic activity or oxidative stress.Msps also do not affect m rna levels of key proinflammatory genes; however, in combination with lipopolysaccharide, they significantly increase extracellular il-1β levels.conclusion:these results suggest that msps could be novel tools for specific drug delivery to microglial cells.

Journal: Nanomedicine (London, England) (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Buckwheat hull-derived biochar immobilized in alginate beads for the adsorptive removal of cobalt from aqueous solutions.

Buckwheat hull-derived biochar (bhbc) beads were synthesized by immobilizing biochar powder with alginate.Due to their cation-exchange ability, abundant functional groups, microporous structure, and large surface area, bhbc beads were successfully applied for the removal of cobalt from aqueous solution.The adsorption behavior followed pseudo-second-order kinetics and the langmuir isotherm model showed a better fit to adsorption data than the freundlich or temkin isotherm models.The maximum adsorption capacity of bhbc beads was 24.0 mg/g at p h 5, 35 °c, and an initial cobalt concentration of 1.0 g/l, which was higher than those of previously reported natural resource-based adsorbents.In a fixed-bed column study, the effects of operating parameters such as flow rate, bed height, and bed diameter were investigated.Both the thomas and yoon-nelson models were applied to the experimental data to predict the breakthrough curves using nonlinear regression.Overall, bhbc beads can be used as an efficient adsorbent for removal of radioactive cobalt from aqueous solution.

Journal: Journal of hazardous materials (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't