syedzayyan/paper_mill_benchmark huggingface dataset:
Potential of honey against the onset of autoimmune diabetes and its associated nephropathy, pancreatitis, and retinopathy in type 1 diabetic animal model.

Honey has been used as a traditional remedy for various health benefits.This study investigated the potential of honey against the onset of autoimmune diabetes and its associated secondary complications in type 1 diabetic (t1d) experimental animals.Autoimmune diabetes was induced in sprague dawley rats, and at the same time, the rats were treated with honey or metformin.Sandwich elisas were used to estimate blood glucose, hemoglobin a1c (hb a1c), total cholesterol, and triglycerides.Histopathological examinations determined the t1d-induced lesions on kidneys, pancreas, cornea, and retina.Treatment of rats with honey during the course of t1d induction showed a significant reduction in fasting-blood-glucose and hb a1c (p< 0.01), and total lipid profile was also improved (p< 0.05).Not only these, but honey also reduced the t1d-induced lesions in the kidney, pancreas, and cornea/retina (p< 0.05).Metformin showed similar effects and was used as a positive control.In conclusion, honey showed therapeutic potential against the onset of autoimmune diabetes, as it reduces blood glucose/hb a1c and improves the lipid profile by reducing the plasma levels of total cholesterol, low-density lipoproteins (ldl), very low-density lipoprotein (vldl), and triglycerides.Moreover, it also showed protective potential against the development of diabetic nephropathy, pancreatitis, and retinopathy.

Journal: Open life sciences (2022)
Publication types: Journal Article
Application of systane complete for the treatment of contact lens discomfort.

To understand the safety of treating contact lens (cl) discomfort with a new artificial tear when it is directly applied to a cl-wearing eye.Methods this was a two-week, two-visit, double-masked study that randomized participants with cl discomfort to use systane complete (artificial tear), sensitive eyes (rewetting drop), or no treatment.Drops were applied before, twice during, and after cl use each day.Corneal staining served as the primary safety metric.Conjunctival staining, tear break-up time, schirmer's test, cl comfort (contact lens dry eye questionnaire-8 [cldeq-8]), and dry eye symptoms (standardized patient evaluation of eye dryness [speed]) were also evaluated.Results this study recruited 73 participants with a mean age of 30.3 ± 11.5 years; 18 % of the participants were male.There were no significant changes in ocular surface signs from baseline or between the artificial tear and rewetting drop groups after two weeks (p ≥ 0.05).Participants in the artificial tear and rewetting drop groups had significant improvements in cldeq-8 scores after two weeks of treatment compared with baseline (p < 0.0001), though scores for this test were not significantly different between these groups after two weeks (p = 0.94).Cldeq-8 scores were significantly better in the artificial tear and rewetting drop groups compared with no treatment after two weeks (p < 0.0001).Conclusions both drops were found to be safe for use with cls while also significantly improving ocular symptoms compared to no treatment after two weeks of use.

Journal: Contact lens & anterior eye : the journal of the British Contact Lens Association (2021)
Publication types: Journal Article
Natural Convection Water/Glycerin-CNT Fractionalized Nanofluid Flow in a Channel with Isothermal and Ramped Conditions.

This article investigates heat and mass transport enrichment in natural convection fractionalized nanofluid flow inside a channel with isothermal and ramped wall conditions under the effects of chemical reactions, radiation, heat absorption, and the soret effect.To obtain the fractional model, the caputo time-fractional derivative definition is used, and analytical results are obtained by the laplace transform.In two base fluids, water and glycerin, the impacts of two nanoparticles, single-wall carbon nanotubes (swcnts) and multiple-wall carbon nanotubes (mwcnts), are investigated.The comparison of six distinct fluids, including water, water-swcnt, water-mwcnt, glycerin, glycerin-swcnt and glycerin-wmcnt, is explored graphically.Physical parameters' effects on isothermal and ramped conditions are graphically depicted and explained in depth.For isothermal wall conditions, the variation in concentration, temperature and velocity is exponential, while for ramped wall conditions, the variation is steady.Finally, the results of skin frictions, nusselt numbers and sherwood numbers and for both ramped wall and isothermal wall conditions are evaluated in tabular form for various values of volume fraction.Moreover, it is observed that the temperature, velocity, nusselt numbers and skin frictions increase by increasing the volume fraction of cnts.

Journal: Nanomaterials (Basel, Switzerland) (2022)
Publication types: Journal Article
PLCOjs, a FAIR GWAS web SDK for the NCI Prostate, Lung, Colorectal and Ovarian Cancer Genetic Atlas project.

Motivation the division of cancer epidemiology and genetics (dceg) and the division of cancer prevention (dcp) at the national cancer institute (nci) have recently generated genome-wide association study (gwas) data for multiple traits in the prostate, lung, colorectal, and ovarian (plco) genomic atlas project.The gwas included 110 000 participants.The dissemination of the genetic association data through a data portal called gwas explorer, in a manner that addresses the modern expectations of fair reusability by data scientists and engineers, is the main motivation for the development of the open-source java script software development kit (sdk) reported here.Results the plco gwas explorer resource relies on a public stateless http application programming interface (api) deployed as the sole backend service for both the landing page's web application and third-party analytical workflows.The core plcojs sdk is mapped to each of the api methods, and also to each of the reference graphic visualizations in the gwas explorer.A few additional visualization methods extend it.As is the norm with web sdks, no download or installation is needed and modularization supports targeted code injection for web applications, reactive notebooks (observable) and node-based web services.Availability and implementation code at project page at

Journal: Bioinformatics (Oxford, England) (2022)
Publication types: Journal Article
Effects of a Novel Gel Formulation of Dog Appeasing Pheromone (DAP) on Behavioral and Physiological Stress Responses in Dogs Undergoing Clinical Examination.

The veterinary visit is necessary for safeguarding the health of dogs, but it can be stressful and threaten both the welfare of the patient and the accuracy of the examination.This randomized, triple-blind, placebo-controlled, crossover study aims at evaluating how dog appeasing pheromone (dap) in a novel gel formulation influences the behavioral and physiological stress responses of 28 dogs undergoing a standardized clinical examination, while staying in the waiting room (wr) and visited in the examination room (er).Behavioral responses were studied through behavioral categories and subjective scales (wr and er).Autonomic response considered heart rate (wr and er), blood pressure (wr and er), respiratory rate (er), and rectal temperature (er).Neuroendocrine response considered salivary cortisol (wr and er).In the waiting room, the use of dap was associated with a significant reduction of lip licking (p= 0.0189), an increase in panting (p= 0.0276), and a reduction close to significance (p= 0.0584) of low body postures.No significant differences were observed within the physiological responses.In the examination room, neither behavioral nor physiological differences were found.

Journal: Animals : an open access journal from MDPI (2022)
Publication types: Journal Article
Comparison of functional and oncological outcomes between uterus-sparing radical cystectomy and standard radical cystectomy in females: A retrospective study.

This study aimed to compare the functional and oncological outcomes of females who underwent uterus-sparing radical cystectomy (usrc) and standard radical cystectomy (src).Materials and methods between february 2009 and december 2020, 90 female patients who underwent radical cystectomy with urinary diversion were included in this study, comprising the usrc and src groups.Functional outcomes were assessed in 63 patients who only underwent radical cystectomy with neobladder formation.Questionnaire scores, clean intermittent catheterization (cic) rate, and urinary continence rate were analyzed.Oncological outcomes were assessed in 86 patients, regardless of the urinary diversion type.Overall survival (os), cancer-specific survival (css), and recurrence-free survival (rfs) were compared.Results cic rate was significantly lower in the usrc group than in the src group (14.7% vs.48.0%; p=0.005).The continence rate was significantly higher in the usrc group than in the src group (85.3% vs.40.0%; p=0.001).There were no significant differences in os (p=0.890), css (p=0.700), or rfs (p=0.270) between the two groups.In multivariate analysis, uterine preservation did not significantly increase the hazard ratio (hr) of os (hr, 0.62; 95% ci, 0.18-2.11; p=0.450), css (hr, 0.99; 95% ci, 0.22-4.40; p=0.990), or rfs (hr, 0.46; 95% ci, 0.19-1.11; p=0.840).Conclusions usrc resulted in higher continence rates and lower cic rates than src without negatively affecting oncological outcomes.Hence, with thorough deliberation, usrc should be considered for females undergoing radical cystectomy.

Journal: Investigative and clinical urology (2022)
Publication types: Journal Article
Depressed Systemic Arterial Compliance is Associated with the Severity of Heart Failure Symptoms in Moderate-to-Severe Aortic Stenosis: a Cross-Sectional Retrospective Study.

Patients with aortic stenosis (as) may develop heart failure even in the absence of severe valve stenosis.Our aim was to assess the contribution of systemic arterial properties and the global left ventricular afterload to graded heart failure symptoms in as.Methods we retrospectively reviewed medical records of 157 consecutive subjects (mean age, 71±10 years; 79 women and 78 men) hospitalized owing to moderate-to-severe degenerative as.Exclusion criteria included more than mild aortic insufficiency or disease of another valve, atrial fibrillation, coronary artery disease, severe respiratory disease or anemia.Heart failure symptoms were graded by nyha class at admission.Systemic arterial compliance (sac) and valvulo-arterial impedance (zva) were derived from routine echocardiography and blood pressure.Results sixty-one patients were asymptomatic, 49 presented mild (nyha ii) and 47 moderate-to-severe (nyha iii-iv) heart failure symptoms.Mild symptoms were associated with lower sac and transvalvular gradients, while more severe exercise intolerance coincided with older age, lower systolic blood pressure, smaller aortic valve area and depressed ejection fraction.By multiple ordinal logistic regression, the severity of heart failure symptoms was related to older age, depressed ejection fraction and lower sac.Each decrease in sac by 0.1 ml/m2 per mm hg was associated with an increased adjusted odds ratio (or) of a patient being in one higher category of heart failure symptoms graded as no symptoms, mild exercise intolerance and advanced exercise intolerance (or: 1.16 [95% ci, 1.01-1.35], p=0.045).Conclusions depressed sac may enhance exercise intolerance irrespective of stenosis severity or left ventricular systolic function in moderate-to-severe as.This finding supports the importance of non-valvular factors for symptomatic status in as.

Journal: International journal of medical sciences (2015)
Publication types: Journal Article
Kinetic Model of Olefins/Isobutane Alkylation Using Sulfuric Acid as Catalyst.

The alkylation of isobutane and low molecular olefins using strong acid as catalysts is an important process in the petrochemical field, and its product, alkylate, is an ideal gasoline blending component due to high octane number, low vapor pressure, low sulfur, and lack of aromatics.To better meet the optimization process of the simulation of the alkylation unit, a reaction kinetic model with 20 reactions based on industrial data was developed, in which the alkylation products were divided into lumped components in detail.The reactor model was established based on the flow state and structural pattern of the industrial reactor, considering the internal circulation flow, and is suitable for the simulation of the du pont alkylation process.Also, eventually, the model parameters were solved by the nonlinear least-squares fitting method.The results of the validation calculations showed that the kinetic model fitted the experimental data with good agreement.In addition, the reaction kinetic model was used to predict the influence of operating conditions, which is consistent with the trend in actual industrial production.

Journal: ACS omega (2022)
Publication types: Journal Article
High-Performance Adhesive Joint Made from Densified Wood.

The strength of an adhesive joint plays a major role in the implementation of engineering wood products; therefore, joint performance receives intense scrutiny.This study investigated a wooden adhesive joint, made from densified wood, the performance of which was dramatically enhanced.The wood sample was developed by performing mechanical compression and polymer impregnation on rubberwood.This treated rubberwood was additionally prepared by simple surface sanding prior to jointing.The highest wettability was found on surfaces sanded with the largest grit sandpaper.Consequently, glueline thickness increased with progressively larger grit (smaller grit number) sandpaper.In addition, the maximum shear strength for the joint made from the densified rubberwood was greater than that of that made from the original one, by 40%.Surprisingly, with the optimal sanding treatment, the shear strength of the wooden joint gradually increased with an increase in the density of the densified rubberwood from 1.05 to 1.30 g/cm3.Moreover, the rate of wood failure also increased throughout the stated density range.

Journal: Polymers (2022)
Publication types: Journal Article
Rate of speech decline in individuals with amyotrophic lateral sclerosis.

Although speech declines rapidly in some individuals with amyotrophic lateral sclerosis (als), longitudinal changes in speech have rarely been characterized.The study objectives were to model the rate of decline in speaking rate and speech intelligibility as a function of disease onset site, sex, and age at onset in 166 individuals with als; and estimate time to speech loss from symptom onset.We also examined the association between clinical (speaking rate/intelligibility) measures and patient-reported measures of als progression (alsfrs-r).Speech measures declined faster in the bulbar-onset group than in the spinal-onset group.The rate of decline was not significantly affected by sex and age.Functional speech was still maintained at 60 months since disease onset for most patients with spinal onset.However, the time to speech loss was 23 months based on speaking rate &lt; 120 (w/m) and 32 months based on speech intelligibility &lt; 85% in individuals with als-bulbar onset.Speech measures were more responsive to functional decline than were the patient-reported measures.The findings of this study will inform future work directed toward improving speech prognosis in als, which is critical for determining the appropriate timing of interventions, providing appropriate counseling for patients, and evaluating functional changes during clinical trials.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Research Support, N.I.H., Extramural
Telemedicine in practice: Patient selection and strategies adopted in spinal care during the COVID-19 era and beyond.

The sars-co v-2 (covid-19) pandemic has had a substantial effect on health-care systems around the world.To deal with this challenge, we developed a prospectus design and test a teleconsultation procedure suitable for both diagnostic and therapeutic needs of outpatients in our spine and spinal cord surgery units.Methods (1) the first 15 patients received in-person and telemedicine visits: our pilot began with screening protocol that involved 15 patients who received an in-person assessment and a telemedicine consult.The 15 patients who were selected were already known to our unit after having had at least one previous in-person visit.Further, they had to be neurologically intact or have a stable neurological examination.The secondary teleconsultation took place as a synchronous face-to-face communication between the doctor and the patient through a video interface (lifesize video conferencing, austin, texas).If the patient demonstrated worsening of symptoms or of their condition, they were rescheduled for an immediate/timely in-person revisit with a spinal physician.(2) fifty patients were offered telemedicine visits alone: 35 accepted: next, from 2020 to 2021, we provided a questionnaire to 50 patients, we deemed eligible for teleconsultations: 35 agreed to the teleconsultations, while 15 refused (i.e., selecting direct in-person assessments).Results we found a comparable quality for the clinical consultations/assessments provided in-person versus through telemedicine.Further, the additional 35 patients who were positively impressed with the quality of the medical care provided utilizing the telemedicine/remote visits alone.Conclusion when pandemic conditions worsen, telemedicine appears to be a viable and important tool/ alternative for spinal surgeons to screen potential patients for treatment/surgery.This preliminary study suggests that a remote examination may be effective, particularly in patients who have previously undergone prior in-person evaluations.

Journal: Surgical neurology international (2022)
Publication types: Journal Article
Actinoplanes lichenicolasp. nov. andActinoplanes ovalisporussp. nov., isolated from lichen in Thailand.

Two actinobacteria, designated as strain ldg1-01tand ldg1-06t, were isolated from lichen samples collected in thailand.Results of morphological characterization, chemotaxonomic studies and 16s r rna gene analysis indicated that both strains were members of the genus actinoplanes.Mk-9(h4) was found as the major menaquinone.The major fatty acids were anteiso-c15 : 0, iso-c15 : 0, iso-c16 : 0and anteiso-c17 : 0.Phosphatidylglycerol, diphosphatidylglycerol, phosphatidylethanolamine and phosphatidylinositol were observed as the polar lipids, but differences in minor unidentified polar lipids were found between the strains.Results of comparative genome analysis based on average nucleotide identity and digital dna-dna hybridization calculations revealed that both strains showed values below 95 and 70 %, respectively, from each other and closely related actinoplanestype strains.Based on data from this polyphasic study, strains ldg1-01tand ldg1-06trepresent novel species of the genus actinoplanes.The names proposed are actinoplanes lichenicolasp.Nov.(type strain, ldg1-01t(=jcm 33066t=tistr 2982t) and actinoplanes ovalisporussp.Nov.(type strain, ldg1-06t=jcm 33067t=tistr 2983t).

Journal: International journal of systematic and evolutionary microbiology (2021)
Publication types: Journal Article
Global magnitude of encephalitis burden and its evolving pattern over the past 30 years.

We aimed to estimate the spatiotemporal patterns of the encephalitis burden along with its attributable risk factors at the national, regional, and global levels, which may be helpful in guiding targeted prevention and treatment programs.Methods based on available data sources, the incidence, mortality, and disability-adjusted life years (dalys) of encephalitis in 204 countries and regions from 1990 to 2019 were reconstructed by the global burden of disease study 2019 using the cause of death ensemble model, spatiotemporal gaussian process regression, and dis mod-mr 2.1.We conducted a systematic analysis on the epidemiological characteristics of encephalitis in detail by gender, region, and age over the past three decades.Results globally, 1,444,720 incident cases, 89,900 deaths, and 4.80 million dalys related to encephalitis were estimated in 2019.The age-standardized incidence rate and age-standardized mortality rate (asmr) decreased from 23.17 and 2.18 to 19.33 and 1.19 per 100,000 person-years over the past 30 years, respectively.However, beginning in 2011-2013, the burden of encephalitis has shown an inflection point, with a further decline of the asrs ceasing.Lower socio-demographic index (sdi) regions in south asia, western and eastern sub-saharan africa had the highest burden of encephalitis in 2019.During the past three decades, most countries of south asia achieved significant control of the burden.In contrast, developed countries with a higher sdi have shown a notable increase in asmr and age-standardized dalys rate.Children and older adults have always been high-risk groups for encephalitis.Conclusion although the global burden of encephalitis has decreased in the past 30 years, a further decline stopped from 2011 to 2013.The diverse burden in different regions calls for differentiated management, and the persistent high burden in some low-sdi regions and the increased burden in developed countries with higher sdis deserve more attention.

Journal: The Journal of infection (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Elucidating the potential neurotoxicity of chiral phenthoate: Molecular insight from experimental and computational studies.

Chiral organophosphorus pollutants are existed ubiquitously in the ecological environment, but the enantioselective toxicities of these nerve agents to humans and their molecular bases have not been fully elucidated.Using experimental and computational approaches, this story was to explore the neurotoxic response process of the target acetylcholinesterase (ach e) to chiral phenthoate and further decipher the microscopic mechanism of such toxicological effect at the enantiomeric level.The results showed that the toxic reaction of ach e with chiral phenthoate exhibited significant enantioselectivity, and (r)-phenthoate (k=1.486 × 105m-1) has a bioaffinity for the nerve enzyme nearly three times that of (s)-phenthoate (k=4.503 × 104m-1).Dynamic research outcomes interpreted the wet experiments, and the inherent conformational flexibility of the target enzyme has a great influence on the enantioselective neurotoxicological action processes, especially reflected in the conformational changes of the three key loop regions (i.e.Residues his-447, gly-448, and tyr-449; residues gly-122, phe-123, and tyr-124; and residues thr-75, leu-76, and tyr-77) around the reaction patch.This was supported by the quantitative results of conformational studies derived from circular dichroism spectroscopy (α-helix: 34.7%→30.2%/31.6%; β-sheet: 23.6%→19.5%/20.7%; turn: 19.2%→22.4%/21.9%; and random coil: 22.5%→27.9%/25.8%).Meanwhile, via analyzing the modes of toxic action and free energies, we can find that (r)-phenthoate has a strong inhibitory effect on the enzymatic activity of ach e, as compared with (s)-phenthoate, and electrostatic energy (-23.79/-17.77 k j mol-1) played a critical role in toxicological reactions.These points were the underlying causes of chiral phenthoate displaying different degrees of enantioselective neurotoxicity.

Journal: Chemosphere (2020)
Publication types: Journal Article