syedzayyan/paper_mill_benchmark huggingface dataset:
Trajectories of Visual and Vestibular Markers of Youth Concussion.

Visual and vestibular deficits, as measured by a visio-vestibular examination (vve), are markers of concussion in youth.Little is known about vve evolution post-injury, nor influence of age or sex on trajectory.The objective was to describe the time trend of abnormal vve elements after concussion.Two cohorts, 11-18 years, were enrolled: healthy adolescents (n= 171) from a high school with vve assessment before or immediately after their sport seasons and concussed participants (n= 255) from a specialty care concussion program, with initial assessment ≤28 days from injury and vve repeated throughout recovery during clinical visits.The primary outcome, compared between groups, is the time course of recovery of the vve examination, defined as the probability of an abnormal vve (≥2/9 abnormal elements) and modeled as a cubic polynomial of days after injury.We explored whether probability trajectories differed by: age (<14 years vs.14+ years), sex, concussion history (0 versus 1+), and days from injury to last assessment (≤28 days vs.29+ days).Overall, abnormal vve probability peaked at 0.57 at day 8 post-injury, compared with an underlying prevalence of 0.083 for uninjured adolescents.Abnormal vve probability peaked higher for those 14+ years, female, with a concussion history and whose recovery course was longer than 28 days post-injury, compared with their appropriate strata subgroups.Females and those <14 years demonstrated slower resolution of vve abnormalities.Vve deficits are common in adolescents after concussion, and the trajectory of resolution varies by age, sex, and concussion history.These data provide insight to clinicians managing concussions on the timing of deficit resolution after injury.

Journal: Journal of neurotrauma (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Research Support, N.I.H., Extramural
Comparison of visibility of iodinated hydrogel and gadolinium-modified hyaluronic acid spacer gels on computed tomography and onboard imaging.

And purpose in accelerated partial breast irradiation (apbi), accurate definition of the tumour bed is crucial to reduce the risk of local recurrence and the volume of healthy tissue irradiated.Recently, hydrogels have been proposed to improve visibility of the lumpectomy cavity for apbi.The aim of this study was to alter two commercially available hyaluronic acid (ha) gels, with gadopentenate dimeglumine (gd), a magnetic resonance imaging (mri) contrast agent.We hypothesize that after injection in the surgical cavity, the mixtures will be visible with computed tomography (ct) for improved treatment planning, cone-beam ct (cbct) for improved patient setup and planar kilovoltage (k v) x-ray for real-time tracking during treatment.Materials and methods in thisex vivostudy, gd was mixed with the two ha gels, and 1 m l of each mixture was injected into fatty and muscular tissue of a pork phantom.Visibility with ct, cbct and planar x-ray imaging was assessed.Contrast-to-noise ratios (cnr) were measured and compared to commercially available iodinated polyethylene glycol (peg).Results the gel mixtures showed increased visibility over ha gels without gd.When comparing cnr of the gel mixtures to that of iodinated peg on ct, there was a 4-fold increase in muscle for both mixtures and a 1.6-fold to 3.6-fold increase in fat, depending on the ha gel.Gel mixtures showed better visibility with planar k v imaging over iodinated peg.Conclusion addition of gd to ha gels increases visibility with ct, cbct and planar x-ray imaging, indicating potential for improved delineation and positioning in apbi.

Journal: Physics and imaging in radiation oncology (2022)
Publication types: Journal Article
Is recipient's body mass index a determinant of short term complications in early renal transplantation?

S obesity prevalence has increased over the past 20 years in the general population and among kidney transplant recipients.General surgical belief is that obesity increases surgical difficulty.The aim of this study was to assess the impact of body mass index (bmi) on perioperative complications.Methods all kidney transplantations performed in adults in our centre from 2006 to 2011 were analysed.Data on patients' characteristics, surgical protocol, intra and postoperative complications and renal function were collected.Patients were divided into 4 groups as follows: underweight (bmi<18.5kg/m2), normal weight (18.5kg/m2≤bmi<25kg/m2), overweight (25kg/m2≤bmi<30kg/m2) and obese (bmi≥30kg/m2).We also studied the impact of bmi on complications using it as a continuous variable to identify potential threshold values.Results among 694 patients included, 52% had normal bmi, 7%, 31% and 9% were underweight, overweight and obese, respectively.In multivariate analysis, overweight was significantly associated with longer operative time compared to normal-weight patients (estimated mean difference of 10,4min, 95% confidence interval (ci) [4.0; 16.9]) and obesity was associated with an increased risk of wound dehiscence (odds ratio 3.1, 95%ci [1.3; 7.3] compared with normal-weight patients).Considering bmi as a continuous variable, the risk of parietal dehiscence significantly increased beyond a bmi of 26kg/m2, intraoperative blood loss and the risk of ureteral stenosis beyond 32kg/m2and the risk of abdominal wall hematoma beyond a bmi of 34kg/m2.Conclusions we found bmi thresholds above which intraoperative blood loss and the risk of parietal dehiscence, ureteral stenosis, and parietal hematoma significantly increased.Level of evidence 3.

Journal: Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie (2020)
Publication types: Journal Article
Mass Spectrometry-Based Proteomics for Biomarker Discovery.

Proteomics plays a pivotal role in systems medicine, in which pharmacoproteomics and toxicoproteomics have been developed to address questions related to efficacy and toxicity of drugs.Mass spectrometry is the core technology for quantitative proteomics, providing the capabilities of identification and quantitation of thousands of proteins.The technology has been applied to biomarker discovery and understanding the mechanisms of drug action.Both stable isotope labeling of proteins or peptides and label-free approaches have been incorporated with multidimensional lc separation and tandem mass spectrometry (lc-ms/ms) to increase the coverage and depth of proteome analysis.A protocol of such an approach exemplified by dimethyl labeling in combination with 2d-lc-ms/ms is described.With further development of novel proteomic tools and increase in sample throughput, the full spectrum of mass spectrometry-based proteomic research will greatly advance systems medicine.

Journal: Methods in molecular biology (Clifton, N.J.) (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, P.H.S.
Treatment of Osteoporotic Compression Fractures at Thoracolumbar Spine With Neurodeficit: Short-Segment Stabilization With Cement-Augmented Fenestrated Pedicle Screws and Vertebroplasty by Minimally Invasive Percutaneous Technique.

Osteoporotic compression fractures often progress to neurological impairment and severe pain, which results in restriction of mobility in elderly patients.Conventional open spinal decompression and stabilization in these patients have significant morbidities related to age, surgical approach, and blood loss.This case series evaluates the treatment of osteoporotic compression fractures at the thoracolumbar junction with short-segment stabilization with cement-augmented fenestrated pedicle screws and vertebroplasty using a minimally invasive percutaneous technique.Methods eleven patients aged 75 years or older who had osteoporotic vertebral fractures with worsening back pain and neurologic impairment were included in this study.Plain radiographs, magnetic resonance imaging, and computed tomography images of these patients were assessed.These patients underwent minimally invasive percutaneous stabilization with cement-augmented fenestrated pedicle screws and vertebroplasty with or without decompression.Preoperative and postoperative american spinal cord injury association score, visual analog scale (vas) score, and charlson comorbidity index were recorded.Cobb angle, spinal alignment, spinal canal encroachment, and anterior vertebral body height were recorded preoperatively and during each follow-up.Results all patients neurologically recovered, and the vas score significantly improved from an average of 9 before surgery to 2 immediately after surgery and 1 at final follow-up (p< 0.001).An average, local angle of kyphosis was 15° preoperatively, which decreased to 7° postoperatively (p< 0.01).The average anterior vertebral body height was 11 mm, which increased to 22 mm postoperatively (p< 0.001).No revision was required due to screw loosening or failure of construct.Conclusion we concluded that patients with osteoporotic vertebral fractures treated with short-segment stabilization with cement-augmented fenestrated pedicle screws and vertebroplasty by minimally invasive percutaneous technique are associated with good clinical outcomes during an average follow-up of 18 months after spinal surgery.Level of evidence: 4

Journal: International journal of spine surgery (2022)
Publication types: Journal Article
Portable Real-Time Detection of Pb(II) Using a CMOS MEMS-Based Nanomechanical Sensing Array Modified with PEDOT:PSS.

Detecting the concentration of pb2+ions is important for monitoring the quality of water due to it can become a health threat as being in certain level.In this study, we report a nanomechanical pb2+sensor by employing the complementary metal-oxide-semiconductor microelectromechanical system (cmos mems)-based piezoresistive microcantilevers coated with pedot:pss sensing layers.Upon reaction with pb2+, the pedot:pss layer was oxidized which induced the surface stress change resulted in a subsequent bending of the microcantilever with the signal response of relative resistance change.This sensing platform has the advantages of being mass-produced, miniaturized, and portable.The sensor exhibited its sensitivity to pb2+concentrations in a linear range of 0.01-1000 ppm, and the limit of detection was 5 ppb.Moreover, the sensor showed the specificity to pb2+, required a small sample volume and was easy to operate.Therefore, the proposed analytical method described here may be a sensitive, cost-effective and portable sensing tool for on-site water quality measurement and pollution detection.

Journal: Nanomaterials (Basel, Switzerland) (2020)
Publication types: Journal Article
Histologic Subtype, Tumor Grade, Tumor Size, and Race Can Accurately Predict the Probability of Synchronous Metastases in T2 Renal Cell Carcinoma.

We investigated the association between synchronous metastases (sms), histologic subtype (hs), tumor size (ts), and tumor grade (tg) in surgically treated stage t2 renal cell carcinoma (rcc).Materials and methods within the surveillance, epidemiology, and end results database (2005-2015), 8344 patients with t2 rcc who had undergone radical nephrectomy were identified.The sm rates were tabulated according to the hs, tg, and ts and tested in multivariable logistic regression models.Results according to the hs, the average sm rates were 0%, 1.4%, 4.6%, 6.4%, 12.7%, 20.0%, and 32.7% for multilocular cystic, chromophobe, papillary, tg 1-2 clear cell, tg 3-4 clear cell, collecting duct, and sarcomatoid dedifferentiation rcc, respectively.In multivariable logistic regression models predicting for sms, hs represented the strongest predictor, followed by tg, ts, and race.When combined, hs, tg, ts, and race predicted for sms with 70.2% accuracy compared with 62.5% with hs, 60.2% with tg, 57.8% with ts, and 53.0% with race alone.Lung only was the most common metastatic site (43.6%), followed by bone only (27.6%), liver only (4.4%), and brain only (4.4%).Of all the patients with sms, 78.9% had a single metastatic site.Conclusions the sm rates showed very wide variation according to the hs, tg, and ts.When hs was combined with tg, ts, and race, sms could be accurately predicted in individual patients better than with ts alone.Thus, renal mass biopsy-derived hs and tg could improve the prediction of sms compared with using ts alone.

Journal: Clinical genitourinary cancer (2020)
Publication types: Journal Article
Comparison of Immediate Blanket Treatment versus a Delayed Pathogen-Based Treatment Protocol for Clinical Mastitis Using an On-Farm Culture Test at a Commercial German Dairy Farm.

The objective of this study was to compare immediate intramammary antimicrobial treatment of mild and moderate cases of clinical mastitis (cm) with a selective treatment protocol based on on-farm culture results using accumast®.The study was conducted at a 2600 cow commercial farm in northeast germany.Using a randomized design, mild and moderate clinical mastitis cases were assigned to either the blanket therapy (bt) or pathogen-based therapy (select) group.Overall, 468 cases were used for final analyses (bt = 236; select = 232).The percentage of cases assigned to the blanket and pathogen-based groups that received intramammary therapy were 100 and 69.9%, respectively.Implementation of a pathogen-based treatment protocol for mild and moderate cm cases resulted in no significant difference in post-event milk production, somatic cell count, survival to 30 d, and days spent in the hospital compared with a blanket therapy protocol.Cows in the select group had reduced odds of being culled within 60 d post cm (odds ratio = 0.54; 95% ci = 0.31-0.93;p= 0.027).The use of a pathogen-based treatment protocol using an on-farm culture system has the potential to efficiently reduce antimicrobial use without negative effects on health.

Journal: Antibiotics (Basel, Switzerland) (2022)
Publication types: Journal Article
Electrochemical sensor for human norovirus based on covalent organic framework/pillararene heterosupramolecular nanocomposites.

Noroviruses are the leading cause of acute gastroenteritis and food-borne diseases worldwide.Thus, a rapid, accurate, and easy-to-implement detection method for controlling infection and monitoring progression is urgently needed.In this study, we constructed a novel sandwich-type electrochemical biosensor integrated with two specific recognition elements (aptamer and peptide) for human norovirus (hu no v).The electrochemical biosensor was fabricated using magnetic covalent organic framework/pillararene heterosupramolecular nanocomposites (mb@apt@wp5a@au@cof@fe3o4) as the signal probes.The sensor showed high accuracy and selectivity.The detection method does not need the extraction and amplification of virus nucleic acid and has a short turn-around time.Intriguingly, the proposed biosensor had a limit of detection of 0.84 copy m l-1for hu no v, which was the highest sensitivity among published assays.The proposed biosensor showed higher sensitivity and accuracy compared with immunochromatographic assay in the detection of 98 clinical specimens.The biosensor was capable of determining the predominant infection strain of gii.4 and also gii.3 and achieved 74% selectivity for hu no v gii group.This study provides a potential method for point-of-care testing and highlights the integrated utilization of apt and peptide in sensor construction.

Journal: Talanta (2022)
Publication types: Journal Article
Facile hydrothermal synthesis of NiTe nanorods for non-enzymatic electrochemical sensing of whole blood hemoglobin in pregnant anemic women.

Electrochemical sensing methods monitor biomolecules because of their specificity, rapid response, lower cost, and automation.Hemoglobin is an abundant protein in the human body and is correlated with various physiological processes.Levels of hemoglobin in blood are associated with anemia in pregnant women.In this research, a non-enzymatic sensor based on ni te nanorods is developed for the detection and quantification of hemoglobin (hb) from anemic pregnant patients.Ni te nanorods are synthesized by the single-step method.After characterizing the material, sensing parameters such as the effect of scan rate, p h, concentration, and interferences are optimized using standard hemoglobin samples.Linearity, the limit of detection (lod), and the limit of quantification (loq) for ni te nanorods are 0.99698, 0.012 n m, and 0.04 n m, respectively.Stability is measured by cyclic chronoamperometry (12 h) and voltammetry (100 cycles).Recovery of hemoglobin from blood samples is in the range of 63-90%.Ni te nanorods quantitatively determine hemoglobin from the blood samples of anemic pregnant women.

Journal: Analytica chimica acta (2022)
Publication types: Journal Article
Impact of COVID-19 vaccine on epilepsy in adult subjects: an Italian multicentric experience.

S to investigate the safety and tolerability of covid-19 vaccines in people with epilepsy (pw e).Methods in this multicentric observational cohort study, we recruited adult patients (age > 18 years old) with epilepsy who attended the outpatient epilepsy clinic from 1st july to 30th october 2021.We administered to the patients a structured questionnaire and interview on demographic and epilepsy characteristics, current treatment, previous sars-co v-2 infection, vaccine characteristics, post-vaccine seizure relapse, other side effect, variation of sleep habits, caffeine, or alcohol intake.Seizure frequency worsening was defined as a ratio between mean monthly frequency post-vaccination and mean monthly frequency pre-vaccination superior to 1.Patients were categorized in two groups: patients with seizure frequency worsening (worse) and patients with seizure stability (stable).Results a total of 358 people participated with a mean age of 47.46 ± 19.04.Focal seizure (79.1%), generalized epilepsy (20.4%), and unknown types of epilepsy (0.5%) were detected among participants.In total, 31 (8.7%) people expressed that they were not willing to receive a covid-19 vaccine; 302 patients (92.35%) did not experience an increase in the seizure frequency (stable-group) whereas 25 patients (7.65%) had a seizure worsening (worse-group).Post-vaccine seizures occurred mainly in the 7 days following the administration of the vaccine.Patients in the worse-group were treated with a mean higher number of anti-seizure medication (asms) (p = 0.003) and had a higher pre-vaccine seizure frequency (p = 0.009) compared with patients in the stable-group.Drug-resistant epilepsy was also associated with seizure worsening (p = 0.01).One-year pre-vaccination seizure frequency pattern demonstrated that patients in the worse-group had a higher frequency pattern (p < 0.001).Multivariate analysis of the vaccinated group showed that only the seizure frequency pattern (confidence interval [ci] = 1.257-2.028; p < 0.001) was significantly associated with seizure worsening.Conclusion in our cohort of vaccinated pw e, only a little percentage had a transient short-term increase of seizure frequency.The present study demonstrates that covid-19 vaccines have a good safety and tolerability profile in the short term in pw e.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2022)
Publication types: Journal Article;Multicenter Study;Observational Study
Electrical stimulation of titanium to promote stem cell orientation, elongation and osteogenesis.

Electrical stimulation of cells allows exogenous electric signals as stimuli to manipulate cell growth, preferential orientation and bone remodelling.In this study, commercially pure titanium discs were utilised in combination with a custom-built bioreactor to investigate the cellular responses of human mesenchymal stem cells via in-vitro functional assays.Finite element analysis revealed the homogeneous delivery of electric field in the bioreactor chamber with no detection of current density fluctuation in the proposed model.The custom-built bioreactor with capacitive stimulation delivery system features long-term stimulation with homogeneous electric field, biocompatible, sterilisable, scalable design and cost-effective in the manufacturing process.Using a continuous stimulation regime of 100 and 200 m v/mm on cp ti discs, viability tests revealed up to an approximately 5-fold increase of cell proliferation rate as compared to non-stimulated controls.The human mesenchymal stem cells showed more elongated and differentiated morphology under this regime, with evidence of nuclear elongation and cytoskeletal orientation perpendicular to the direction of electric field.The continuous stimulation did not cause p h fluctuations and hydrogen peroxide production caused by faradic reactions, signifying the suitability for long-term toxic free stimulation as opposed to the commonly used direct stimulation regime.An approximate of 4-fold increase in alkaline phosphatase production and approximately 9-fold increase of calcium deposition were observed on 200 m v/mm exposed samples relative to non-stimulated controls.It is worth noting that early stem cell differentiation and matrix production were observed under the said electric field even without the presence of chemical inductive growth factors.Statement of significance: this manuscript presents a study on combining pure titanium (primarily preferred as medical implant materials) and electrical stimulation in a purpose-built bioreactor with capacitive stimulation delivery system.A continuous capacitive stimulation regime on titanium disc has resulted in enhanced stem cell orientation, nuclei elongation, proliferation and differentiation as compared to non-stimulated controls.We believe that this manuscript creates a paradigm for future studies on the evolution of healthcare treatments in the area of targeted therapy on implantable and wearable medical devices through tailored innovative electrical stimulation approach, thereby influencing therapeutic conductive and electroactive biomaterials research prospects and development.

Journal: Acta biomaterialia (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Multirate Processing with Selective Subbands and Machine Learning for Efficient Arrhythmia Classification.

The usage of wearable gadgets is growing in the cloud-based health monitoring systems.The signal compression, computational and power efficiencies play an imperative part in this scenario.In this context, we propose an efficient method for the diagnosis of cardiovascular diseases based on electrocardiogram (ecg) signals.The method combines multirate processing, wavelet decomposition and frequency content-based subband coefficient selection and machine learning techniques.Multirate processing and features selection is used to reduce the amount of information processed thus reducing the computational complexity of the proposed system relative to the equivalent fixed-rate solutions.Frequency content-dependent subband coefficient selection enhances the compression gain and reduces the transmission activity and computational cost of the post cloud-based classification.We have used mit-bih dataset for our experiments.To avoid overfitting and biasness, the performance of considered classifiers is studied by using five-fold cross validation (5cv) and a novel proposed partial blind protocol.The designed method achieves more than 12-fold computational gain while assuring an appropriate signal reconstruction.The compression gain is 13 times compared to fixed-rate counterparts and the highest classification accuracies are 97.06% and 92.08% for the 5cv and partial blind cases, respectively.Results suggest the feasibility of detecting cardiac arrhythmias using the proposed approach.

Journal: Sensors (Basel, Switzerland) (2021)
Publication types: Journal Article