syedzayyan/paper_mill_benchmark huggingface dataset:
Total Thoracoscopic versus Robotic Surgery for Repair of Atrial Septum Defect: A Propensity Matching Score Analysis

Robotic surgery can provide less surgical trauma than conventional surgery, but differences between robotic and thoracoscopic surgery for atrial septal defect (asd) repair are not well documented.To explore whether asd can be repaired by thoracoscopic surgery or robotic surgery, which procedure is less invasive, and the difference in outcomes between these two procedures, this article studies 160 patients undergoing asd repair at our institution.Sixty-five patients underwent total thoracoscopic surgery and 95 patients underwent total endoscopic robotic surgery.Propensity score matching yielded 64 well-matched patient pairs.Surgical data and early postoperative outcomes between the two matched groups were analyzed and compared.The results show that thoracoscopic and robotic surgery to repair asd are both safe and reliable, and the early curative effect is good.However, regardless of similar complication rates, robotic surgery has a shorter time, less postoperative drainage, and faster recovery than thoracoscopic surgery.

Journal: Emergency Medicine International (2022)
Publication types: Clinical Study;
To Investigate the Effect of Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) in the Diagnosis of Mild Craniocerebral Injury

In order to assess the value of magnetic resonance imaging (mri) and diffusion tensor imaging (dti) in microscopic brain scans.Diffusion tensor imaging (dti) and magnetic resonance spectroscopy (mri) changes over time in patients with traumatic brain injury (tbi) show a relationship between recovery from coma and overall glasgow prognostic parameters.The value of dti combined with mri in evaluating tbi has been investigated.10 patients with tbi received 10 evaluations of magnetic resonance imaging, dti and mri scans.Thalamic plate nucleus, reticular nucleus, and retinal developmental activity were measured in normal controls and tbi coma (2‐3 weeks) and mild (&gt;4 weeks) patients.Anisotropy, mean diffusion coefficient, axial diffusion coefficient, and radial diffusion coefficient were measured using mri together with acetylaspartic acid, choline, creatinine, and lactic acid.Independent control t ‐tests were conducted between controls and tbi patients, and 1‐test paired between moderate and severe injuries, and regression and correlation were evaluated.Evaluated for all measures and treatments.Dti and mri scores in tbi patients differed from normal controls.Dti and mri can predict the prognosis of tbi patients better.The limitations of the thalamus‐retinal activation system are gradually restored.Axial diffusion coefficient and radial diffusion coefficient can be used to evaluate the reliability of comatose patients with tbi.Dti and mri scans of the patient’s brain can predict recovery and guide treatment in tbi coma patients.

Journal: BioMed Research International (2022)
Publication types: Research Article;
To Explore the Application of PDCA in Hemodialysis Center and Its Effect on the Maintenance of Internal Fistula

The survey found that in recent years, with the incidence of chronic kidney disease (ckd) increasing, some patients with ckd even progressed to end‐stage renal disease.Luckily, progressive hemodialysis technology and nursing level can improve the quality of life and prognosis of patients.Objective .To explore the application of plan‐do‐check‐adjust (pdca) cycle in the management of nurses in hemodialysis center and its effect on the maintenance of internal fistula in patients.Methods .In this study, a randomized controlled trail (rct) was used to select 90 patients who underwent maintenance hemodialysis in the hemodialysis center of our hospital from january 2018 to june 2021 as objects.They were divided into a pdca group (with pdca nursing management) and routine group (with routine nursing management) by random number table with each of 45 cases for 6 months to compare the differences of the internal fistula complications, internal fistula maintenance quality, patients’ microinflammatory state, and satisfaction with nursing, as well as nursing staff’s operational and theoretical performance between the two groups.Results .There was no significant difference in crp, il‐1, tnf‐ α , and il‐6 levels between the two groups before intervention ( p &gt; 0.05); after that, these levels in the pdca group were lower than those in the routine group, with statistically significant difference ( p &lt; 0.05); before intervention, there was no statistically significant difference in the qualification rate of blood flow, the awareness rate of health education, and the incidence of nursing defects between the two groups ( p &gt; 0.05); after that, the qualification rate of blood flow and the awareness rate of health education among nurses in pdca group were higher than those in routine group, while the incidence of nursing defect accidents in the pdca group was lower than that in routine group, and the differences were statistically significant ( p &lt; 0.05); before intervention, there was no significant difference in the complication rate between the two groups ( p &gt; 0.05); after that, the complication rate of the pdca group was lower than that of the routine group, and the differences were statistically significant ( p &lt; 0.05); after intervention, the theoretical assessment and practical skills assessment scores of the pdca group were higher than those of the routine group, and the differences were statistically significant ( p &lt; 0.05); after intervention, the nursing satisfaction of the pdca group was higher than that of the routine group, and the differences were statistically significant ( p &lt; 0.05).Conclusion .The application of pdca approach in the management of nurses in hemodialysis centers can effectively improve the quality of internal fistula management and improve the practical and theoretical level of nurses, as well as reduce the microinflammation of patients.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
The Use of Cytotoxic Drugs as First Line Chemotherapy for EGFR (+) Nonsquamous NSCLC: A Network Meta-Analysis

To assess the use of cytotoxic drugs as first-line chemotherapy for nonsquamous non-small-cell lung cancer (nsclc) with egfr mutation.Method.This study uses the network meta-analysis (nma) method, with the inclusion of prospective randomized control studies related to the treatment of egfr-positive nonsquamous nsclc, to compare the efficacy of various egfr-tkis.As of september 4, 2022, 16 studies on a total of 4180 patients were included.The retrieved literature was comprehensively evaluated as per the established inclusion and exclusion criteria, and valid data were extracted and included for analysis.Results.The 6 treatment regimens included cetuximab, ctx (cyclophosphamide), icotinib, gefitinib, afatinib, and erlotinib.All of the 16 studies reported their findings about overall survival (os), and 15 of them also reported findings about progression-free survival (pfs).The nma results showed that there was no significant difference in os among the 6 treatment regimens.It was observed that erlotinib had the highest likelihood of obtaining the best os, followed by afatinib, gefitinib, icotinib, ctx, and cetuximab, in descending order.This indicates that the highest possibility of achieving the best os was with erlotinib, while the lowest was with cetuximab.The nma results also showed that the pfs achieved with treatment using afatinib, erlotinib, and gefitinib were all higher than that with treatment using ctx, with statistically significant differences.The results showed that there was no significant difference in pfs among erlotinib, gefitinib, afatinib, cetuximab, and icotinib.Ctx, cetuximab, icotinib, gefitinib, afatinib, and erlotinib were ranked in descending order based on the pfs indicator sucra values, which implied that erlotinib had the highest possibility in achieving the best pfs, while ctx had the lowest.Discussion.Egfr-tkis must be carefully selected for the treatment of different histologic subtypes of nsclc.For egfr mutation (+) nonsquamous nsclc, erlotinib is most likely to achieve the best os and pfs, which makes it the first choice in the formulation of a treatment plan.

Journal: Disease Markers (2023)
Publication types: Meta-Analysis;
The Temporal and Spatial Changes of Th17, Tregs, and Related Cytokines in Epilepsy Lesions

The cellular and molecular mechanisms in pathogenesis and development of epilepsy are still unclear.Specific inflammatory mediators and immune cells may play an important role.The aim of the present study was to investigate the temporal and spatial changes of th17, tregs, and related cytokines in epilepsy lesions.Li cl-pilocarpine-induced temporal lobe epilepsy (tle) rat models were established, sensorimotor function was examined using modified neurological severity score (m nss), cognitive function was evaluated by morris water maze (mwm) test, pathological damages were detected by h&amp;e staining and nissl staining, helper t cells 17 (th17), regulatory cd4+ t cells (tregs), and their related cytokines were detected by western blotting and immune staining.Results showed that th17 and its related cytokines in epilepsy lesions played a role mainly at acute phase of epilepsy, and they were positively correlated with the pathological changes in the hippocampus and neurological and cognitive dysfunction caused by epilepsy.Conversely, tregs and their related cytokines mainly played a role at progressive phase and had the opposite effect.Th17 and tregs restricted each other during the recovery phase to achieve functional balance.Our results suggested that th17, tregs, and related cytokines in epilepsy lesions played an important role in the pathogenesis and development of epilepsy and balancing th17 and tregs may be efficacious therapeutics for patients with epilepsy.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
The Role and Clinical Observation of Traditional Chinese Medicine in Relieving Senile Insomnia: A Systematic Review and Meta-Analysis

To assess the role and clinical observation of traditional chinese medicine (tcm) in relieving senile insomnia and conduct a systematic evaluation and meta‐analysis.Methods .We searched chinese literatures from some database, including the china knowledge network database, chongqing cqvip chinese database, wanfang database, and chinese biomedical literature database.In addition, english literature retrieval database pub med and the cochrane library were included in this meta‐analysis.The randomized controlled trial (rct) of cognitive behavioral therapy was found in the treatment of chronic insomnia.All articles were current up to december 1, 2021, and references in the literature were hand searched.Results .About 16 studies were included, involving 1260 elderly patients with insomnia.Meta‐analysis results showed that compared with the control group, the sleep latency of the experimental group md = −8.02, 95% ci (10.95, 5.01), the number of awakenings of the experimental group md = −0.41, 95% ci (0.68, 0.14), the total sleep time of the experimental group md = 39.41, 95% ci (27.05, 51.71), the sleep efficiency of the experimental group md = 7.82, 95% ci (1.87, 13.75) the pittsburgh sleep quality index of the experimental group md = 2.41, 95% ci (3.12, 1.46), the effective rate of the experimental group: or = 3.12, 95% ci (1.76, 5.48), and the insomnia severity index of the experimental group md = 1.05, 95% ci (2.04, 0.52).Conclusion .Our current study has indicated that tcm may play a central role in relieving senile insomnia and may be effective when treating insomnia.However, due to the low quality of trial methodology and publication bias, it cannot be fully confirmed.Further high‐quality trials are needed to be investigated in the future.

Journal: BioMed Research International (2022)
Publication types: Meta-Analysis;Review Article;
The Relationship between Cuff Pressure and Air Injection Volume of Endotracheal Tube: A Study with Sheep Trachea Ex Vivo

Endotracheal intubation is a widely used treatment.Excessive pressure of the endotracheal tube cuff leads to a series of complications.Here, we used tracheae of sheep to analyze the relationship between the air injection volume and endotracheal tube cuff pressure so as to guide the doctors and nurses in controlling the pressure of the endotracheal tube cuff during clinical work and minimise the risk of complications.Materials and methods.Forty sheep tracheae were utilised and were divided into five groups according to their diameters.Different sizes of endotracheal tubes were inserted into each trachea, and the cuff pressure with the increase of air injection volume was recorded.The formulas that reflect the relationship between air injection volume and cuff pressure were obtained.Then, sheep tracheae were randomly selected; different types of tubes were inserted, and the stipulated volume of air was injected.The actual pressure was measured and compared with the pressure predicted from the formulas.Statistical analysis was conducted to verify whether the formulas obtained from the first part of the experiment were in accordance with the expert evaluation table, which consists of opinions of several experts.Results.After obtaining 15 formulas, we collected the differences between the theoretical cuff pressure and the actual cuff pressure that satisfied the expert evaluation.Relying on the formulas, the medical turntable was obtained, which is a tool that consists of two round cards with data on them.The top card has a notch.The two cards are stacked together, and as the top card rotates, the data on the bottom card can be easily seen in a one-to-one relationship.Conclusion.The formulas are capable of showing the relationship between the cuff air injection volume and pressure of endotracheal tube cuff.The medical turntable can estimate the air injection volume to ensure that the pressure stays in an acceptable range.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
The Practical Effect of Action Intervention Strategy Combined Based on Surgical and Psychological Factors

This study mainly analyzes the related surgical and psychological factors that cause the change of thirst degree after gastrointestinal surgery, and observes the practical effect of action intervention strategy combined with the two factors on reducing postoperative thirst degree.Based on this, the clinical data of 87 patients who underwent gastrointestinal tumor resection in our hospital from january 2020 to january 2021 is retrospectively analyzed.The degree of thirst is evaluated by the visual analogue scale (vas) and the subjects are divided into three groups: a mild group ( n = 29), a moderate group ( n = 35), and a severe group ( n = 23), and their psychological and surgical indicators are compared and analyzed.The results show that the thirst degree and light comfort of mouth in the study group are better than those in the control group at 2 h after surgery, and there is no significant difference when compared to 6 h after surgery, but the thirst degree and oral discomfort in the control group at 6 h after surgery are significantly higher than those in the study group at 2 h after surgery.It is suggested that an action research intervention strategy with a high practical effect can effectively reduce postoperative thirst and oral discomfort.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
The Optimal Integration of Computer Information Technology and Energy Economic Management

The author proposes a method combining entropy weight method and topsis method with computer information technology in order to save energy with maximum efficiency and improve efficiency.The author constructs the optimal integration of computer information technology and enterprise economic management.Managers use computer information technology to analyze data and problems more accurately and have stronger control ability.The noncooperative game model of gender warfare game and smart pig game are used to simulate negotiation and cooperation in reality, which is conducive to the formulation of cooperation mechanisms and the flexibility of negotiation to promote the realization of regional energy cooperation.Finally, combined with computer information technology, a comprehensive evaluation model of the energy economic system is constructed by using the entropy weight method and the topsis method.The authors used a paired t test for the three evaluation results to examine whether their evaluation results were significantly different.Experimental results show that the correlation coefficient between method 1, method 2, and method 3 are both 0.984, and the correlation coefficient between method 2 and method 3 is 0.974, and the results are all significant.Conclusion.The method can effectively improve the efficiency and effectiveness of energy economy, and the detection results are better.

Journal: International Transactions on Electrical Energy Systems (2022)
Publication types: Research Article;
The Nine RNA Methylation Regulatory Gene Signature Is Associated with the Pathogenesis of Atrial Fibrillation by Modulating the Immune Microenvironment in the Atrial Tissues

Atrial fibrillation (af) is the most common type of cardiac arrhythmias and a major cause of cardiovascular disease (cvd)-related deaths globally.Rna methylation is the most frequent posttranscriptional modification in the eukaryotic rnas.Previous studies have demonstrated close associations between the status of rna methylation and cvd.Methods.We comprehensively evaluated the relationship between rna methylation and af.Least absolute shrinkage and selection operator (lasso) logistic regression analysis was used to establish a risk score model in af.Biological functional analysis was used to explore the relationship between rna methylation related signatures and immune microenvironment characteristics.Machine learning was used to recognize the outstanding rna methylation regulators in af.Results.There was a significant variant of the m rna expression of rna methylation regulators in af.Rna methylation related risk score could predict the onset of af and closely associated with immune microenvironment features.Xg-boost algorithm and shap recognized that nsun3 and dcps might play a key role in the development of af.Meanwhile, nsun3 and dcps had potential diagnostic value in af.Conclusion.Rna methylation regulatory genes are associated with the onset of af by modulating the immune microenvironment.The nine af risk-related rna methylation regulatory gene signature is a potential diagnostic biomarker and therapeutic target for af.

Journal: Disease Markers (2023)
Publication types: Research Article;
The Mediating Role of Alexithymia: Social Support and Depression among Colorectal Cancer Patients

The purpose of this study was to investigate the relationship among depression, alexithymia, and social support and examine the main influence factors of depression in patients with colorectal cancer (crc).In addition, the mediating role of alexithymia between social support and depression was analyzed.Methods.Patients with crc were recruited in two tertiary hospitals in changchun via a convenience sampling method.All survivors were asked to complete self-report questionnaires assessing medical and demographic variables, depression, alexithymia, and social support.Results.A total of 183 patients with crc were included.The results showed that education level and family monthly income were the main factors affecting depression patients with in crc.Alexithymia was positively correlated with depression ( r = 0.389 , p &lt; 0.01 ).Social support was negatively correlated with alexithymia ( r = − 0.322 , p &lt; 0.01 ) and depression ( r = − 0.316 , p &lt; 0.01 ).Moreover, alexithmia partially mediated the relationship between social support and depression, and the ratio of mediating effect with total effect was 23.82%.Conclusions.To sum up, there is a correlation between depression, social support, and alexithymia in patients with crc; alexithymia plays a partially intermediary role in the impact of social support on depression.Our findings remind clinicians to treat the depression of patients with crc from multiple perspectives, such as by increasing social support and reducing alexithymia.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
The Investigation on Nosocomial Infection of Acinetobacter baumannii and the Clinical Analysis of Sequential Therapy of Cefoperazone/Sulbactam Sodium for Intracranial Infection

Intracranial infection is a serious complication after neurosurgery.According to a survey, the incidence of intracranial infection is about 2.2%-2.6%, and patients with severe symptoms may even pose a threat to their life safety.Objective.To explore the risk factors for intracranial infection caused by acinetobacter baumannii after surgery and the clinical effect of sequential therapy of cefoperazone/sulbactam sodium.Methods.In this study, a retrospective study was used.In this case-control study, 48 cases of intracranial acinetobacter baumannii infection after neurosurgery in our hospital from january 2016 to december 2021 were selected as the infection group, and 96 patients without intracranial infection after surgery during the same period were selected as the control group to study all kinds of related factors and analyze the risk factors for intracranial acinetobacter baumannii infection; in addition, in accordance with the therapeutic regimen for anti-infection, the infection group was divided into the tigecycline group (patients with tigecycline therapy in this group) and the combined group (patients with tigecycline combined with cefoperazone/sulbactam sequential therapy), with 24 cases in each group in order to compare the therapeutic effects of the two groups.Results.Logistic regression factor model results show that increasing age of patients, surgical treatment for intracranial tumor or craniocerebral trauma, postoperative drainage time (≥3 days), and postoperative hospital stay (≥10 days) were the risk factors for postoperative intracranial infection of acinetobacter baumannii in neurosurgical patients ( p &lt; 0.05 ), and postoperative prophylactic antibiotic treatment can reduce the incidence of intracranial infection ( p &lt; 0.05 ).The cerebrospinal fluid nucleated cell count, serum crp, and serum pct in the combined group 72 h after treatment were lower than those in the tigecycline group, and the difference was statistically significant ( p &lt; 0.05 ).Compared with the clinical efficacy after 72-hour treatment, the cure rate and effective rate in the combined treatment group were 83.33% and 16.67%, respectively, and those in the tigecycline group were 54.17% and 33.33%, respectively.The invalid interest rate was 12.50%, and the combined treatment group was superior to the tigecycline group ( p &lt; 0.05 ).Conclusion.For patients with craniocerebral surgery, targeted preventive interventions should be carried out for the risk factors that may lead to intracranial acinetobacter baumannii infection.The clinical effect of tigecycline combined with cefoperazone and sulbactam sodium sequentially in the treatment of intracranial acinetobacter baumannii infection is better.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;