syedzayyan/paper_mill_benchmark huggingface dataset:
Protective impacts of circular RNA VMA21 on lipopolysaccharide-engendered WI-38 cells injury via mediating microRNA-142-3p

Circ rna derived from vacuolar atpase assembly factor (circ vma21) is a newly‐researched circ rna, which is reported to adjust the degeneration of intervertebral disc.But, function of circ vma21 in infantile pneumonia is yet to be explored.The research surveyed the role of circ vma21 in lipopolysaccharide (lps)‐caused wi‐38 cell inflammatory injury.Lps (10 μg/ml, 12 hr) was exploited to arouse wi‐38 cell inflammatory injury.Subsequently, the mediatory impacts of micro rna (mi r)‐142‐3p and circ vma21 in lps‐evoked cell injury were detected after transfection with the inhibited or overexpressed vectors.In above processes, cell behaviors of cell viability, apoptosis, and pro‐inflammatory factors were monitored.Nf‐κb and jnk pathways were elucidated to showcase the feasible molecular mechanisms.Results displayed that lps engendered wi‐38 cell inflammatory injury was alleviated as well as activated nf‐κb and jnk pathways was interdicted by mi r‐142‐3p suppression.Importantly, restrained mi r‐142‐3p expression was discovered in wi‐38 cells after overexpressing circ vma21.Moreover, overexpressed circ vma21 exerted the similar functions as mi r‐142‐3p suppression in lps‐triggered wi‐38 cell injury.But, the influence was clearly reversed by mi r‐142‐3p overexpression.Hindered nf‐κb and jnk pathways caused by overexpressed circ vma21 was also crippled by mi r‐142‐3p overexpression.The research discolsed that circ vma21 protected wi‐38 cells to resist lps‐triggered inflammatory injury via mi r‐142‐3p‐nf‐κb/jnk axis.

Journal: Biofactors (2019)
Publication types: Research Article;
Circular RNA ANKRD36 attends to lipopolysaccharide-aroused MRC-5 cell injury via regulating microRNA-31-3p

Background some circular rnas (circ rnas) are reported to attend to the pathogenesis of pneumonia.This study tested the impact of circ rna ankyrin repeat domain 36 (circ ankrd36) on human embryonic lung fibroblast mrc‐5 cell injury irritated by lipopolysaccharide (lps).Methods after lps irritation, viability, apoptosis, ros, protein, and cytokines, along with circ ankrd36 were tested by cck‐8, annexin v‐fitc, dcfh‐da, and elisa or western blot.Si‐circ ankrd36 and micro rna‐31‐3p/5p (mi r‐31‐3p/5p) inhibitor were applied to silence circ ankrd36 and mi r‐31‐3p/5p.Mi r‐31‐3p/5p mimic was utilized to upregulate mi r‐31‐3p/5p.Rt‐q pcr was used to detect mi rnas.The relationship between mi rnas and my d88 or il‐34 was analyzed by luciferase activity reporter assay.Results lps aroused a decrease in viability, increases in apoptosis, ros, and il‐6, il‐8, and tnf‐α, along with circ ankrd36, and activation of nf‐κb pathway.Silencing circ ankrd36 weakened the above‐mentioned influences of lps.Moreover, silencing circ ankrd36 hoisted mi r‐31‐3p expression.Silencing mi r‐31‐3p mitigated the impacts of circ ankrd36 silence on lps‐irritated mrc‐5 cells.Besides, my d88 was a downstream target of mi r‐31‐3p, and 3′utr of il‐34 m rna was targeted by mi r‐31‐5p.Lps induced the accumulation of my d88.Silencing my d88 was constructive to maintain cell viability, retard apoptosis and inhibit adverse oxidation and inflammation.Conclusion this research verified that silencing circ ankrd36 could weaken lps‐irritated mrc‐5 cell injury via regulating mi r‐31/my d88‐mediated repression of nf‐κb pathway.

Journal: Biofactors (2019)
Publication types: Research Article;
microRNA-29b inhibits cell growth and promotes sensitivity to oxaliplatin in colon cancer by targeting FOLR1

The present study was aimed to explore the functional role of micro rna (mi r)‐29b in colon cancer, as well as underlying mechanisms.Expressions of mi r‐29b and folate receptor 1 (folr1) were measured in both human colon tumor samples and cell lines.Colon cancer cell lines sw480 and sw620 were transfected with mi r‐29b mimic, antisense oligonucleotides (aso)‐mi r‐29b, small interfering (si rna) against folr1 (si‐folr1), or corresponding negative controls (ncs), and then were incubated with or without oxaliplatin (l‐ohp).Thereafter, cell viability, cytotoxicity, cell apoptosis, and expression of folr1, atp binding cassette subfamily g member 2 (abcg2) and p‐glycoprotein (p‐gp) were analyzed.We found that mi r‐29b was significantly decreased, while folr1 was statistically elevated in colon cancer samples and cell lines compared to the nontumor samples and nontumourigenic immortalized human colon epithelial cell line fhc.Overexpression of mi r‐29b markedly inhibited cell viability, promoted sensitivity to l‐ohp, stimulated cell apoptosis (all p &lt; .05), and decreased the levels of abcg2 and p‐gp in cancer cells, whereas suppression of mi r‐29b showed contrary results.Moreover, we observed that folr1 was a direct target of mi r‐29b and was negatively regulated by mi r‐29b.In addition, the findings revealed that the effects of folr1 inhibition on cell viability, sensitivity to l‐ohp, cell apoptosis, and the levels of abcg2 and p‐gp were similar to overexpression of mi r‐29b.Taken together, our study suggests that mi r‐29b inhibits cell growth and promotes sensitivity to l‐ohp in colon cancer by targeting folr1.

Journal: Biofactors (2019)
Publication types: Research Article;
MicroRNA-575 targets BLID to promote growth and invasion of non-small cell lung cancer cells

This study was designed to detect mi r‐575 expression and function in non‐small cell lung cancer (nsclc).A higher expression of mi r‐575 in nsclc tissues was observed compared with adjacent non‐neoplastic tissues.Furthermore, re‐introduction of mi r‐575 significantly promoted cell proliferation, migration, and invasion in the nsclc line.Moreover, we showed that blid is negatively regulated by mi r‐575 at the posttranscriptional level, via a specific target site within the 3′utr.Overexpression of blid counteracted mi r‐575‐induced proliferation and invasion in nsclc cells.The expression of blid is frequently downregulated in nsclc tumors and cell lines and inversely correlates with mi r‐575 expression.The findings of this study contribute to the current understanding of the functions of mi r‐575 in nsclc.

Journal: FEBS Letters (2015)
Publication types: Research Article;
A stepwise-targeting strategy for the treatment of cerebral ischemic stroke

Background effective amelioration of neuronal damages in the case of cerebral ischemic stroke (cis) is essential for the protection of brain tissues and their functional recovery.However, most drugs can not penetrate the blood–brain barrier (bbb), resulting in the poor therapeutic outcomes.Results in this study, the derivatization and dual targeted delivery technologies were used to actively transport antioxidant melatonin (mlt) into the mitochondria of oxidative stress-damaged cells in brain tissues.A mitochondrial targeting molecule triphenylphosphine (tpp) was conjugated to melatonin (tpp-mlt) to increase the distribution of melatonin in intracellular mitochondria with the push of mitochondrial transmembrane potential.Then, tpp-mlt was encapsulated in dual targeted micelles mediated by tgn peptide (tgnykalhphng) with high affinity for bbb and shp peptide (clevsrkng) for the glutamate receptor of oxidative stress-damaged neural cells.tgn/shp/tpp-mlt micelles could effectively scavenge the overproduced ros to protect neuronal cells from oxidative stress injury during cis occurrence, as reflected by the improved infarct volume and neurological deficit in cis model animals.Conclusions these promising results showed this stepwise-targeting drug-loaded micelles potentially represent a significant advancement in the precise treatment of cis.Graphical abstract

Journal: Journal of Nanobiotechnology (2021)
Publication types: Research Article;
Advances in Plant Genetic Engineering Based on the Analysis of Big Data from the Perspective of Biological Mechanism

By exploring the in-depth understanding of biological mechanism and plant genetic engineering and its application in production and life in recent decades, this paper briefly describes the concept, research contents and significance of plant genetic engineering based on the analysis of big data, puts forward the important role of priming factors in plant genetic engineering induction, and introduces the latest research results of plant genetic engineering.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
Clinical Efficacy Analysis of Conbercept Intravitreal Injection for Fundus Diseases Based on Computer Simulation

Fundus diseases can seriously damage the visual acuity of patients, including age-related macular degeneration (armd), retinal choroidal neovascularization (cnv), retinal vein occlusion (rvo), central serous chorioretinopathy (csc), diabetic retinopathy (dr), etc.At the same time, fundus disease generally has a long course, high severity, long-term delay, high recurrence rate, and as long as the patients do not receive timely treatment or do not receive the correct treatment, there will be a variety of complications, causing serious damage to the structure of the patient’s eyes and the patient’s visual function.Clinical trial simulation (cts) is a newly emerging interdisciplinary subject in recent years.With the increasing cost in the process of new drug development, computer simulation technology has attracted extensive attention of pharmaceutical enterprises.Clinical treatment of fundus diseases includes hormone therapy, etiological treatment, vitrectomy, laser treatment, etc, but the effect is different.This study mainly analyzes the effect of intravitreal injection of conbercept in the treatment of fundus diseases.Based on the analysis and research of cts research at home and abroad, aiming at the relationship between dosage, blood concentration and efficacy, the change of blood concentration under different dosage was analyzed, and the influence on drug effect under different administration scheme was predicted.Main work: establishment of simulation model (including proportional advantage model, pharmacokinetics / pharmacodynamics model), simulation calculation, model simulation and result analysis.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
Research on Application of Top-down Construction Method Based on Computer Technology in Excavation of Urban Deep Foundation Pit

With the development of urban construction in three dimensions, the increase of urban high-rise buildings and the in-depth utilization of underground space, the requirements for the excavation and support of deep foundation pit projects based on computer technology are getting higher and higher.The advantages of reverse method in urban deep foundation pit excavation make it quickly popularized and applied, which has high research value.This paper first introduces the application of the reverse method in the deep foundation pit support, then analyses the design of the reverse method, and finally studies the application of the reverse method in the urban deep foundation pit construction design [1-3] .

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
miR-519d downregulates LEP expression to inhibit preeclampsia development

The purpose of the current study was to characterize role of micro rna (mi r)-519d in trophoblast cells and preeclampsia (pe) development and its potential underlying mechanism.Regulation of leptin (lep) by mi r-519d was verified using a dual-luciferase reporter gene assay.Loss- and gain-of-function assays were conducted to detect the roles of mi r-519d and lep in proliferation, migratory ability, and invasive capacity of htr-8/svneo cells by means of cck-8 assay, scratch test, and transwell invasion assay, respectively.The cell apoptosis rate and cycle distribution were analyzed by flow cytometry.Lep expression was elevated, whereas mi r-519d level was suppressed in the pe placenta samples compared with those from normal pregnancy.Depletion of lep promoted proliferation, migratory ability, and invasive capacity and repressed apoptosis.Mi r-519d could bind 3′ untranslated regions (3′utrs) of lep, the extent of which correlated negatively with lep expression.Mi r-519d suppressed the expression of lep in htr-8/svneo cells.Moreover, overexpression of mi r-519d promoted survival and migratory ability of htr-8/svneo cells.Taken together, we find that mi r-519d targeted lep and downregulated its expression, which could likely inhibit the development of pe.

Journal: Open Medicine (2021)
Publication types: Research Article;
Research of Smart Tourism Management Model under the Background of Big Data

In recent years, communication and information technology have developed rapidly, and various industries are rapidly transforming into digitalization, informatization, and intelligence, thus entering a new era of big data.Smart tourism is no longer a slogan.It has become the goal of the transformation of the tourism.In the context of the development of big data, the essence of smart tourism is researched and the ideas of smart tourism development and construction are discussed.A platform can be used to build tourism service prediction and feedback, and the path of building a smart platform can be discussed.

Journal: Journal of Physics: Conference Series (2020)
Publication types: Conference Abstract/Paper;
Research on the Course Innovation of Construction Engineering Cost under the Concept of the OBE Based on Big Data Analysis

According to big data analysis, with the continuous improvement of international engineering quality requirements, obe concept has become an important method in construction engineering, which has been widely used in the teaching reform of cost course.Based on the obe concept, curriculum innovation will advocate novel teaching methods and evaluation concepts, which is a “student-centered” education concept.Through the integration and innovation of obe concept, we will complete the teaching reform of engineering cost course, which will provide better applied talents for the society.First of all, this paper analyzes the necessity of obe concept to the teaching of engineering cost course.Then, this paper puts forward some questions.Finally, some suggestions are put forward.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
SNHG5 promotes proliferation and induces apoptosis in melanoma by sponging miR-155

Melanoma is the most common malignancy of skin cancer.Small nucleolar rna host gene 5 (snhg5), a long non-coding rna (lnc rna), has been demonstrated to be upregulated in tumor tissues and cells of melanoma.

Journal: RSC Advances (2018)
Publication types: Research Article;
Research on the Connotation, Mechanism and Practice of Green Finance based on the Analysis of Big Data

With the national economy development under the background of computer, china’s per capita income continues to increase, which also strengthens the prosperity of china’s financial industry.However, the rapid economic growth is based on the plunder of natural resources, which has caused great damage to the natural environment.Therefore, we must be responsible for the environmental pollution, which requires financial institutions to pay close attention to and prevent the financial risks caused by potential environmental pollution, which is the fundamental purpose of the green finance development.Britain, japan, the european union and other countries have carried out a variety of attempts, which requires our country to continue to learn and accumulate green finance.China’s banking industry has issued a series of green financial policies, which need our financial institutions to pay more attention to.In practice, green finance has encountered many problems.Based on the operation mechanism of green finance, this paper puts forward some problems.

Journal: Journal of Physics: Conference Series (2020)
Publication types: Conference Abstract/Paper;
Financial Risk Control of Sports Industry Based on Big Data

With the widespread use of internet big data, all walks of life are developing rapidly, among which the sports industry has also encountered new development opportunities and challenges.Based on the background of big data era, this paper studies the financial risk control of sports industry in the era of big data.This paper will first give readers a specific introduction to what is big data and let them know the main characteristics of the era of big data; then, it will analyze and further discuss the potential financial risks in the sports industry; finally, it will study the development of sports industry and how to control financial risks in the era of big data.In the analysis, this paper through the investigation of the development trend of the fitness industry, shows that there are risks in the fitness industry, and this risk is fatal to the fitness industry.Then, based on the background of big data, this paper puts forward corresponding suggestions on the risk control of the fitness industry, hoping that this study can provide certain reference for the healthy development of the fitness industry.

Journal: Journal of Physics: Conference Series (2020)
Publication types: Conference Abstract/Paper;
Design of life assistance device for the elderly based on artificial intelligence

With the development of the times, china has entered a stage of aging population.Because of the increase of age, the elderly are often hard to finish like bend over, squat such simple actions, which brought great challenge to the basic life of old people.Some basic activities such as walking and the toilet, are very difficult for them.In order to guarantee the basic life of the elderly, a kind of life assistance device for the elderly based on artificial intelligence is designed to help the elderly in walking and toilet.The mechanical structure of the device mainly consists of five parts, namely, walking mechanism, lifting mechanism, rotating seat cushion mechanism, rotating handrail mechanism and pulling rod backrest mechanism.The control part is mainly based on voice recognition technology.The device is simple in structure, convenient in operation and low in cost.Compared with the existing life assistance devices for the elderly, the device has more complete functions, which better solves the difficulties of the elderly in walking and using the toilet, and provides great convenience for the elderly.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
Research on Optimization Plan of Enterprise Employee Training under the Background of Big Data

This article takes smes as the research object, and aims to study the problems and optimization schemes of sme employee training under the background of big data.This article uses a combination of literature reading, statistical analysis and questionnaire survey to investigate the employees of a certain company’s specific production base, and conducts research and analysis on the company’s employee training management.This article first introduces some concepts of modern enterprise training, and then analyzes the status quo of enterprise employee training.Through the interviews and questionnaires issued to the employees of the company, it analyzes the problems and causes of the company’s employee training management, and provides optimized solutions for the company’s employee training.The experimental results of this paper show that the optimization of corporate employee training programs under the background of big data plays a positive role in corporate management.It improves employee enthusiasm and work commitment, and increases the number of corporate trainings.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
Innovation of Cross-border E-commerce Practice Teaching Based on Big Data

With the development of the times, cross-border e-commerce has gradually become an important course, but the current teaching methods are difficult to provide students with good teaching.Based on the background of big data, this article hopes to practice cross-border e-commerce in schools the teaching finds a practical form with good feasibility, and summarizes from it that can reflect the universally applicable internal laws, so that the school’s e-commerce teaching can make more students realize the role of big data.Studies have shown that cross-border e-commerce practice teaching under the background of big data is more popular among students than the current traditional teaching model, with a favorable rate of over 90%.And in terms of teaching efficiency, the efficiency of teaching based on big data reaches 0.835, which is much higher than traditional teaching methods.This shows that practical teaching of cross-border e-commerce based on big data can play an important role.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
Research on Personalized Healthy Diet Recommendation Based on Artificial Intelligence

With the development of the internet, china’s good data mining technology in e-commerce has achieved development, and the recommendation service has gradually become popular and has been adopted by the majority of citizens.In order to facilitate people to quickly find what they need from a large number of commodities and save consumers’ time, the recommendation system pays more and more attention to the user experience.This paper constructs a healthy diet recommendation model based on improved apriori.When judging the user’s dietary preferences, the improved apriori algorithm is used to recommend the diet.The original algorithm and the improved algorithm are compared to the same example.The results show that the improved algorithm has advantages in mining association rules and can better realize personalized healthy diet recommendations.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
Analysis on the Competitiveness of Global Agricultural Remote Sensing Research Based on Artificial Intelligence Technology

In order to accelerate the overall progress of digital agricaulture, fully grasp the global agricultural remote sensing research, and support the basic application research of global agricultural remote sensing, this paper uses web of science as the data resouce, adopts bibliometrics and artificial intelligence methods, and excel, vosviewer and other tools are used to provide a comprehensive analysis of sci journal articles on global agricultural remote sensing research in terms of the overview of article publication, institutions, authors, and topics.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
Analysis of research situation of domestic tomato irrigation and fertilization based on artificial intelligence technology

To fully grasp the development trend of research on tomato irrigation and fertilization in my country.This article uses cnki journal database as the data source, using knowledge graph method, with the help of excel, vos viewer and other tools.A comprehensive analysis of the core scientific and technological journal papers of my country’s tomato irrigation and fertilization research is carried out from the aspects of publication volume, institutions, authors, journals, frequency of citations, disciplines, topics, and fund distribution.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;