syedzayyan/paper_mill_benchmark huggingface dataset:
Effects of Ganoderic Acid A on Gastrointestinal Motility and Brain-Gut Peptide in Rats with Functional Dyspepsia

The therapeutic effect of drugs for functional dyspepsia (fd) is still limited.Ganoderic acid a (gaa) has anti-inflammatory and cellular protective activities.The aim of this study is to explore the therapeutic effect of gaa on fd.Methods.The fd rat model was established via tail damping and forced exercise fatigue.The gastric emptying rate and intestinal propulsion rate of the rats in each group were then detected, and the pathological damage of gastric antrum and duodenum tissues was observed by hematoxylin-eosin (he) staining.An enzyme-linked immunosorbent assay (elisa) was conducted to determine the levels of motilin (mtl), vasoactive intestinal peptide (vip), leptin, gastrin (gas), calcitonin gene-related peptide (cgrp), and somatostatin (ss) in plasma, and western blot was used to detect the protein expression levels of occludin, zonula occluden-1 (zo-1), and junctional adhesion molecule-1 (jam-1) in the duodenal tissue.Results.Treatment with gaa significantly raised the gastric emptying rate and intestinal propulsion rate of fd rats and histologically alleviated the gastric and duodenal damage.Meanwhile, gaa positively regulated the secretion of brain-gut proteins, such as upregulation of mtl, gas, and ss and downregulation of vip, leptin, and cgrp.In addition, gaa treatment increased the protein expression levels of occludin, zo-1, and jam-1 in the duodenal tissue of the fd rats.Conclusion.Gaa may exhibit protective effects on fd by regulating the secretion of brain-gut peptide, protecting the intestinal barrier and improving gastrointestinal motility.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Effect of Minimally Invasive Puncture Drainage and Conservative Treatment on Prognosis of Patients with Cerebral Hemorrhage

The objective of this study was to explore the effect of minimally invasive puncture drainage under unsupervised learning algorithm and conservative treatment on the prognosis of patients with cerebral hemorrhage.Fifty patients with cerebral hemorrhage were selected as the research objects.The ct images of patients were segmented by unsupervised learning algorithm, and the application value of unsupervised learning algorithm on ct images of patients with cerebral hemorrhage was evaluated.According to the treatment wishes of the patients themselves and their authorizers, they were divided into 30 patients with cerebral hemorrhage in the minimally invasive group and 20 patients with cerebral hemorrhage in the conservative group.The incidence rate of complications of cerebral hemorrhage, the length of hospitalization of the two groups, hematoma volume at admission, 3 days and 7 days after operation, and the hematoma dissipation rate on the 3rd and 7th day after operation were used as the evaluation index of therapeutic effect.Mrs and adl scores were used as prognostic indicators.The results show that k-means clustering algorithm has high quality and short time for ct image segmentation.The overall incidence rate of complications in minimally invasive group was 10%, lower than that in conservative group (25%) ( p &lt; 0.05 ), and the length of hospitalization in minimally invasive group was longer than that in conservative group ( p &lt; 0.05 ).The hematoma volume of minimally invasive group was 16.5 ± 2.4 m l on the 3rd day after operation, and that of conservative group was 27.4 ± 1.8 m l.There was significant difference between the two groups ( p &lt; 0.05 ).In addition, ct showed that the hematoma reduction degree of minimally invasive group was higher than that of conservative group, and the hematoma dissipation rate was higher than that of conservative group on the 3rd and 7th day ( p &lt; 0.05 ).The good mrs score in minimally invasive group was 3.15 times that in conservative group, and the good adl score was 1.6 times that in conservative group, and there was significant difference in the total score between the two groups ( p &lt; 0.05 ).Minimally invasive puncture drainage is better than conservative treatment in the clearance of hematoma, which is conducive to the recovery of neurological function and daily life of patients with cerebral hemorrhage and is of great help to the prognosis of patients.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Effect of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) Combined with Hyperbaric Oxygen (HBO) on Awakening of Coma Patients with Traumatic Brain Injury

Coma caused by craniocerebral injury is a common condition of neurosurgical acute injury.There is no specific method to promote awakening in a clinic.Early comprehensive treatment may be helpful to patients.The common methods are hyperbaric oxygen (hbo) and low-frequency repetitive transcranial magnetic stimulation (r tms).However, the application effect and mechanism of r tms combined with hbo on coma patients with traumatic brain injury need to be further studied.The brain stem auditory evoked potential (baep) is examined by the kennedy coma recovery scale (crs-r), the recovery of brain function and the state of consciousness are evaluated, and the therapeutic effect is evaluated by the glasgow coma scale (gcs).Cerebrospinal fluid ne level, mca blood flow velocity, and left brainstem and right brainstem auditory evoked potential are used to evaluate brain rehabilitation.Rtms combined with hbo could shorten the wake-up time, improve the wake-up rate, improve the gcs score and crs-r score, shorten the brain wave latency time of the left and right brainstem, increase the ne level of cerebrospinal fluid, and decrease the blood flow velocity of mca.Rtms combines with hbo can improve the nerve excitability of brain cells, reduce the disturbance of consciousness, promote the functional recovery of brain injury, and has a certain role in promoting the awakening of patients with traumatic brain injury coma.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Porcine Fibrin Sealant Promotes Skin Wound Healing in Rats

Fibrin sealant (fs) is widely used for skin wound healing, but data on porcine fs (pfs), a new type of fs, are limited.This study investigated the effects and potential mechanisms of porcine fibrin sealant (pfs) on skin wound healing in rats.Methods.Traumatic rats were randomly divided into three groups: control, pfs, and medical vaseline.The wound area and wound index of the rats were measured within 14 days after surgery.Hematoxylin-eosin (h&amp;e) staining and masson staining were used to observe the pathological images and collagen formation on the wounded skin, respectively.To investigate the healing mechanisms, the enzyme-linked immunosorbent assay (elisa) was used to detect platelet endothelial cell adhesion molecule-1 (cd31) and cluster of differentiation 34 (cd34) expression in the wounded skin.Additionally, quantitative real-time pcr (q rt-pcr) was used to evaluate the m rna levels of the vascular endothelial growth factor (vegf), fibroblast growth factor (fgf), and epidermal growth factor (egf), and transforming growth factor-β1 (tgf-β1).Meanwhile, tgf-β1 protein expression was assessed by western blot analysis.Results.Compared with the control group, both pfs and medical vaseline treatment significantly reduced the wounded area and increased the wound closure rate.H&amp;e staining showed that the cells in the pfs group proliferated rapidly, and the epidermis and dermis were thickened to some extent with a clear epidermal cell structure.Moreover, pfs promoted the formation of collagen and significantly increased the levels of cd31 and cd34 and the growth factors in the skin tissues of the traumatic rats.Conclusion.Pfs effectively promoted skin wound healing, especially in tissue formation, reepithelialization, angiogenesis, and collagen deposition, in traumatic rat models.This study provides a new strategy and scientific foundation for pfs application in skin wound healing.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Rehabilitation Treatment of Muscle Strain in Athlete Training under Intelligent Intervention

With the development of artificial intelligence technology in the medical field, clinical trials using artificial intelligence as an intervention method are constantly emerging.This article mainly introduces the intervention of artificial intelligence and emotional intelligence on the rehabilitation of athletes’ muscle strains.Among them, artificial intelligence and emotional intelligence are a brand-new nursing intervention method.This article compares conventional rehabilitation therapy with these two new types of intelligent interventions to explore the effects of artificial intelligence intervention and emotional intelligence intervention in the rehabilitation of athletes.The experimental results show that the average number of muscle restrains under the intervention of artificial intelligence is 4.1 times, the average restrain rate of muscles is 27.7%, and the average recovery degree of athletes is 94.7%.The average spb score under emotional intelligence intervention was 56 points.Artificial intelligence interventions can enhance rehabilitation through advanced technology, and emotional intelligence interventions can provide emotional support to effectively improve treatment outcomes and quality of life.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Innovation and Entrepreneurship of College Students Based on Random Matrix Big Data Analysis Model Educational Ecological Model Optimization

In this paper, the random matrix big data analysis model is thoroughly studied and constructed, the ecological model of college students’ innovation and entrepreneurship education is analyzed, and the optimization model of college students’ innovation and entrepreneurship education environmental model based on the random matrix big data analysis model is designed.This paper briefly explains the random matrix and its m-p rate theory deduces the idea of feature extraction by the difference of eigenvalue limit spectrum distribution between different nonrandom matrices and random matrices, gives the data matrix representation method of fempl and the specific feature composition basis, and describes the steps of fempl feature extraction.A performance model for predicting the running time of hadoop jobs is constructed using a random matrix.In this paper, innovation and entrepreneurship education has been carried out gradually, and the innovation and entrepreneurship education curriculum, platform, and mechanism have been progressively established.However, there is still a gap between the proper level of innovation and entrepreneurship education development.This study takes education ecology as the research perspective, analyzes the ecosystem of typical schools of innovation and entrepreneurship education, summarizes the dimensions and parameters of the invention and entrepreneurship education ecosystem, constructs an ecological model of innovation and entrepreneurship education for college students, and analyzes the problems and causes of the current innovation and entrepreneurship education ecology for college students based on the model, to propose specific strategies to promote the ecological development of innovation and entrepreneurship education for college students.

Journal: Mathematical Problems in Engineering (2022)
Publication types: Research Article;
Radiation Exposure of Crystalline Bodies during Interventional Therapy and Related Research Status

The aim of this study was to estimate the exposure dose level of ocular corpuscles during the common interventional procedures of interventional radiology workers.This article retrospectively analyzed the general instruments and equipment of interventional therapy, the general methods and steps of interventional therapy, and the influence of x‐ray of interventional surgery.The related contents of eye protection for interventional radiology workers were summarized.This study found that there was a significant linear correlation between the equivalent dose of lens and the exposure time.The tube voltage, tube current, and the size of fluoroscopic field of vision also have an impact on the radiation of workers during surgical exposure.Interventional surgery is difficult and easy.The exposure time of difficult surgery is relatively long, so the dose received by interventional staff is large.The intervention staff should improve their professional knowledge, be proficient in the operation technology, and try to reduce the exposure without affecting the diagnosis and treatment effect.During the intervention operation, the eye substance of the operator is exposed to a certain dose of radiation, and the wearing rate of protective lead glasses of the intervention staff is very low.Therefore, we must pay attention to the protection of the eyes, strengthen the protection management, and reduce the exposure dose of the intervention staff as much as possible.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
What Determines the Behavior of a System and How to Design a Satisfactory System for an Expected Behavior

Systems are everywhere around us, such as products, production lines, the internet, companies, schools, hospitals, airports, communities, cities, countries, governments, and military forces.System researchers and engineers always strive to achieve their desired system behaviors.Thus, this paper aims to solve two fundamental problems of systems engineering: what determines the behavior of a system and how to design a satisfactory system for the expected behavior.First, we determine the dimensions of a relationship flow, such as information flow, material flow, and capital flow.Second, we develop new theorems and propositions to solve the first problem.For example, they show that, for a given behavior of a system, if the dominant subsystem of the behavior has the basic level for the behavior, the behavior is only determined by its input flow and relationship flows at or above the basic level, all of which are collectively referred to as total relationship flow (trf).Third, we develop a relationship flow diagram which is of great significance to system design, just as a circuit diagram to circuit design, and a trf-oriented system design framework to solve the second problem.In order to show how the framework works, we apply it step by step to the schematic design of an airport system for the required passenger departure procedure service behavior, and get a system example; using this framework to design a system will greatly simplify the complexity of development and improve the maintainability of the system.Therefore, our findings provide a new theory for systems engineering and improve its methods and tools systematically.

Journal: Mobile Information Systems (2022)
Publication types: Research Article;
Quetiapine Combined with Sodium Valproate in Patients with Alzheimer’s Disease with Mental and Behavioral Symptoms Efficacy Observation

Quetiapine combined with sodium valproate is an effective and more suitable drug treatment for alzheimer’s disease.At present, there are relatively few studies on the combined action mechanism of these two drugs.This study has certain practical value.Alzheimer’s disease is a multifaceted, highly genetically heterogeneous neurodegenerative disease.The main clinical manifestations are memory loss, abnormal mental behavior, and loss of various cognitive functions.In order to improve the symptoms of patients with alzheimer’s disease, especially those with mental symptoms, this article combines quetiapine and sodium valproate, two commonly used drugs for the treatment of mental illnesses, and applies them to different levels of alzheimer’s and observes the results of the combination’s curative effect.This article introduces alzheimer’s disease and its potential mental behaviors in the method section, and it also introduces the mechanism of action of quetiapine and sodium valproate.For the algorithm, this paper introduces a data mining algorithm to understand the effect of drug efficacy.In the experimental part, firstly, it introduces the experimental objects, the proportion of medicines, and the statistical methods.Secondly, this article covers adverse reactions, inflammatory factors and vascular endothelial indicators, alzheimer’s disease performance, moas score, treatment effect evaluation, and satisfaction surveys.It can be seen from the experiment that, in mental behavior, the experimental group decreased from 8.2 before treatment to 0.5, and the control group decreased from 7.1 before treatment to 2.6.It can be seen that the scores of the experimental group changed after receiving the treatment of quetiapine combined with sodium valproate.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Preparation and Optical Properties of Compound Nanopowder Art Ceramics

The fluorescent glass of white leds has high physical and chemical stabilities, good heat dissipation performance, and can maintain an excellent performance of fluorescent powder itself.In order to realize luminescent materials such as white led lighting, laser lighting, and long-term lighting, this study proposes the preparation of a compound nanopowder art ceramic and its optical properties.In order to play the role of nanoparticles in optoelectronic or photonic devices, it is necessary to explore the preparation process and performance research of dielectric ceramics.This study uses high-purity aluminate (mg al2o4) powder for transparent ceramics, doped with yellow nanophosphor as raw materials, through a sintering process in oxygen atmosphere, sintering combined with heat treatment, and isostatic pressing to prepare transparent ceramics.The ceramic sample is placed in a high-temperature and high-pressure environment for heat and other static pressure, and fluorescent samples are obtained.The results show that under 350 m a driving current, high-power white leds in the fluorescent ceramic package have almost no attenuation after 700 h, and the average attenuation of the led package of the phosphor package is about 10%.The use of fluorescent ceramics can be packaged not only to improve the led device’s light efficiency but also to increase the life of the white led device.

Journal: International Journal of Analytical Chemistry (2022)
Publication types: Research Article;
Melatonin attenuates TNF-α-mediated hepatocytes damage via inhibiting mitochondrial stress and activating the Akt-Sirt3 signaling pathway

The role of mitochondrial dysfunction and its molecular mechanism in inflammation‐induced acute liver failure (alf) remain unknown.Despite the numerous studies performed to date, very few therapies are available for inflammation‐induced alf.Therefore, our study is aimed to explore the regulatory effects of mitochondrial stress and the akt‐sirt3 pathway on the development of tnf‐α‐induced hepatocyte death and assess the therapeutic effects of melatonin on the damaged liver.Our results exhibited that tnf‐α treatment induced hepatocyte damage in vitro; the effect of which was dose‐dependently inhibited by melatonin.At the molecular level, tnf‐α‐treated hepatocytes expressed lower levels of sirt3 and subsequently exhibited mitochondrial stress.Interestingly, melatonin treatment improved mitochondrial bioenergetics, reduced mitochondrial oxidative stress, reversed mitochondrial dynamics, and repressed mitochondrial apoptosis by reversing the decrease in sirt3 expression after tnf‐α challenge.In addition, we found that melatonin‐regulated sirt3 expression in a manner dependent on the akt pathway.Blockade of the akt pathway abolished the protective exerted by melatonin on mitochondria and hepatocyte under tnf‐α treatment.In conclusion, tnf‐α promotes hepatocyte apoptosis by inducing mitochondrial stress.However, melatonin significantly increases the activity of the akt/sirt3 axis and consequently maintains mitochondrial homeostasis, restoring hepatocyte viability in an inflammatory environment.Thus, the information compiled here might provide important perspectives for the use of melatonin in the clinic for preventive and therapeutic applications in patients with alf based on its anti‐inflammatory and mitochondria‐protective effects.

Journal: Journal of Cellular Physiology (2019)
Publication types: Research Article;
Effect of Core Stability Training on Correction and Surface Electronic Signals of Paravertebral in Adolescent Idiopathic Scoliosis

To observe the effect of 12‐week core stability training on cobb angle and the ratios of aemg (averaged emg) and iemg (integral emg) of paravertebral electromyography in thoracic and lumbar segments in adolescent idiopathic scoliosis (ais) patients and offer a practical‐based evidence for the rehabilitation treatment for ais patients.Methods .31 ais female middle school students were randomly divided into an exercise group ( n = 16, 12 weeks of core stability training, 3 times/week) and ais group ( n = 15).In addition, 15 female secondary school students without scoliosis were included as the normal group (the ais group and normal group did not perform any regular physical exercise throughout the trial period and only receive regular evaluation and guidance).Before and after the experiment, the digital diagnostic equipment of philips was used to examine the cobb angle and noraxon was used to measure the surface emg signals of the back thoracic and lumbar paravertebral muscles.Results .Compared with that before training, after 12 weeks of core stability training, the cobb angle in the exercise group significantly decreased, and the ratio of aemg (convex/concave) and iemg (convex/concave) of paravertebral muscles in the thoracolumbar segment significantly decreased ( p &lt; 0.01, respectively); there was no significant difference in the above indicators in the ais group before and after the experiment ( p &gt; 0.05, respectively).After 12 weeks of core stability training, compared with the ais group, the cobb angle decreased significantly ( p &lt; 0.01), and the ratio of aemg (convex/concave) and iemg (convex/concave) of paravertebral muscles in thoracolumbar segment decreased significantly ( p &lt; 0.01, p &lt; 0.05).Compared with the normal group, the ratio of aemg and iemg of paravertebral muscles in thoracolumbar segment significantly increased ( p &lt; 0.01) in the ais group ( p &lt; 0.01, respectively).Conclusions .The core stability training can significantly reduce the cobb angle of ais and correct the bad posture of scoliosis patients, which may be related to the balance of the electromyographic activities (convex concave side) of paravertebral muscles in ais patients.

Journal: BioMed Research International (2022)
Publication types: Research Article;