syedzayyan/paper_mill_benchmark huggingface dataset:
First Record of Ichthyofauna from Gomal Zam Dam, District South Waziristan, Khyber Pakhtunkhwa, Pakistan

The present study reports the fish fauna of gomal zam dam at three different sites from october 2018 to july 2019.The total sampled fish belong to 18 species, 15 genera, 5 families, and 4 orders.Fourteen species belong to family cyprinidae, which was the most abundant, while one species belong to each family mastacembelidae, channidae, siluridae, and sisoridae.The prominent species were labeo dyochielus (18.6%), barilius vagra (16.5%), and barilius pakistanicus (13.8%), while the rare species were tor zhobensis , wallago attu , hyphophthalmicthys molitrix , ctenophyrngodon idella , and bagarius bagarius each one forming (0.1%).Species were rich in spring with ideal temperature, followed by summer, whereas species abundance was high in summer with high temperature and minimum abundance was recorded in autumn.In conclusion, the gomal zam dam is a favorable reservoir for the fish particularly for family cyprinidae.This present study will provide useful information about the diversity of fish fauna of gomal zam dam that could be used in systematic fisheries management and conservation of the country.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Effect of miR-25 on Proliferation of Nasopharyngeal Carcinoma Cells through Wnt/β-Catenin Signaling Pathway

To investigate the biological role and potential mechanism of mi r‐25 in nasopharyngeal carcinoma.Methods .The expression of mi r‐25 in nasopharyngeal carcinoma cell lines was detected by q rt‐pcr.The effect of inhibition of mi r‐25 expression on the proliferative activity of nasopharyngeal carcinoma cell line hone‐1 was examined by cck‐8 method.Flow cytometry was used to detect the effect of mi r‐25 expression inhibition on the apoptosis rate of nasopharyngeal carcinoma cell line hone‐1.The mi rna target gene prediction site target scan predicts the target protein action site of mi r‐124 and verifies whether mi r‐25 interacts with the target by luciferase activity assay, q pcr, and western experiments.The mi r‐25 inhibitor and target egg gene expression plasmids were cotransfected into hone‐1 cells for rescue experiments to investigate whether mi r‐25 inhibits proliferation of nasopharyngeal carcinoma cells by target genes.At the same time, q rt‐pcr was used to detect the m rna expression levels of wnt/ β ‐catenin pathway key proteins tcf4, c‐myc, and cyclin d1 in different transfected cells.Results .Mi r‐25 expression was upregulated in nasopharyngeal carcinoma cell lines.Functional studies showed that inhibition of mi r‐25 expression significantly inhibited the proliferation of nasopharyngeal carcinoma cell line hone‐1 ( p &lt; 0.05).Inhibition of mi r‐25 expression by flow cytometry significantly promoted apoptosis ( p &lt; 0.05).Detection of dual luciferase activity indicated that dkk3 is a direct target site for mi r‐25.Western blots showed that inhibition of mi r‐25 significantly upregulated dkk3 m rna and protein levels.Supplementation with dkk3 significantly attenuated the inhibitory effect of mi r‐25 on the proliferation of nasopharyngeal carcinoma cell line hone‐1 ( p &lt; 0.05).Q rt‐pcr found that m rna levels of tcf4, c‐myc, and cyclin d1 were significantly upregulated in mi r‐25‐transfected cells compared to control transfection.Qrt pcr showed that the m rna and protein levels of tcf4, c‐myc, and cyclin d1 were significantly upregulated in mi r‐25 overexpression‐transfected cells.Conclusion .Inhibition of mi r‐25 expression promotes dkk3 gene expression, and inactivation of wnt/ β ‐catenin signaling pathway inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Effect and Repair Mechanism of Nano Ag Sponge Dressing Combined with Gelatin-Bletilla Striata Gum/Salvia Miltiorrhiza on Refractory Orthopedic Wounds

To explore the effect and mechanism of the sponge dressing on the healing of refractory orthopedic wound, and the gelatin‐bletilla striata gum/salvia miltiorrhiza nano ag (gbs‐ag) sponge dressing was prepared.Methods .Gbs‐ag sponge dressing was prepared by the freeze‐drying method.Twenty male sd rats were randomly divided into the control group (ctrl group) and gbs‐ag group, with 10 rats in each group, and the rats in the two groups were established a model of back wound infection.The ctrl group was treated with gauze, while the gbs‐ag group was treated with gbs‐ag sponge dressing.Wound healing rate, blood immune indexes, ag content in each organ, morphological changes of wound, and expression of transforming growth factor‐ β 1 (tgf‐ β 1) in wound transformation were detected in the two groups of rats.Results .The mechanical properties of gbs‐ag sponge dressing were all in line with the standard, and it had good killing effect on the conventional strain after being incubated for 24 hours.Compared with the ctrl group, the healing rate and lymphocyte percentage in the gbs‐ag group were significantly increased on day 4 and day 10 ( p &lt; 0.05), while the total number of white blood cells and the percentage of neutrophils were significantly decreased ( p &lt; 0.05).Compared with ctrl group, the ag content in liver, spleen, and kidney of rats in the gbs‐ag group was significantly increased ( p &lt; 0.05).The histological results showed that the ctrl group lacked collagen fibers in the dermis, and the angiogenesis was not rich, accompanied by a large number of inflammatory cell infiltration.The epidermal repair of rats in the gbs‐ag group was complete and partially keratinized, the dermis was rich in collagen fibers, with elastic fibers and new blood vessels, inflammatory cells were rare, and new hair follicles and thick‐walled blood vessels were also observed.The expression of tgf‐ β 1 protein in the wounds of rats in the gbs‐ag group was higher than that of the ctrl group.Conclusion .Gbs‐ag sponge dressing had multiple effects of sterilization and promoting wound healing, and its mechanism may be related to promoting the tgf‐ β 1 protein expression.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Clinical Effect of Flexible Ureteroscope and Laparoscope in the Treatment of Parapelvic Cyst

Comparing the clinical effect of flexible ureteroscope and laparoscope in the treatment of parapelvic cyst.Method .A total of 82 patients with parapelvic cyst who underwent surgical treatment in our hospital from may 2019 to may 2020 were selected.Patients were randomly divided into a control group and an observation group; the control group underwent laparoscopic parapelvic cyst topical decompression; the observation group underwent transurethral flexible ureteroscope holmium laser incision and drainage of parapelvic cyst.The intraoperative (operative time, intraoperative blood loss, and ventilation time), postoperative (time of getting out of bed, pain score, and length of hospital stay), and recurrence were compared between the two groups.Results .(1) the operative time and intraoperative blood loss in the observation group were significantly better than those in the control group ( p &lt; 0.05), while the ventilation time had no significant difference ( p &gt; 0.05).(2) the pain score and length of hospital stay in the observation group were better than those in the control group ( p &lt; 0.05).There was no significant difference in the time of getting out of bed ( p &gt; 0.05).(3) there was no serious infection or bleeding in either group.The observation group had no recurrence, and the postoperative recurrence rate was 0.There were 11 cases of recurrence in the control group, and the postoperative recurrence rate was 26.83%.The postoperative recurrence rate of the observation group was significantly lower than that of the control group, with statistical significance ( χ 2 = 4.604, p &lt; 0.05).Conclusion .Flexible ureteroscope for the treatment of parapelvic cyst could effectively reduce the operative time, intraoperative blood loss, and pain; in addition, the postoperative recovery was fast and the recurrence is rare, which was worth popularizing.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Clinical Application of Peritoneal Dialysis Catheterization without Capsular Puncture Technique

To summarize the advantages of peritoneal dialysis (pd) catheters without capsular puncture (only one pneumoperitoneum needle) puncture technique conducted by our center.Methods .The study examines the clinical data of pd patients (including the general situation of patients, intraoperative and postoperative characteristics, and complications) undergoing pneumoperitoneum needle catheterization from january 2019 to may 2021 in the department of nephrology at the first affiliated hospital of hebei north university (the largest peritoneal dialysis center in zhangjiakou).Results .A total of 153 surgical cases were collected.There were 91 males and 62 females.The mean (± standard deviation) age was 56.1 ± 18.6 years, and the mean (± standard deviation) follow‐up time was 16.7 ± 8.2 months.The average operation time was 30.33 minutes with a standard deviation of 14.80 minutes.The length of abdominal incision is 2.38 ± 0.42 cm, and the blood loss was about 26.3 ± 9.2 ml, including 2 cases of laparoscopic reposition of drift tube, 0 case of pipe blockage, 3 cases of fluid leakage, 1 case of peritoneal dialysis catheter tunnel infection, 4 cases of outlet infection, 12 occurrences of peritonitis, 121.3 patient months in peritonitis, and 0 times in omentum wrapping without bladder injury, incisional hernia, or intestinal injury.Conclusion .Relative to open operation, the peritoneal dialysis (pd) catheters with pneumoperitoneum needle puncture technique has the following advantages: simpler operation, shorter operation time, less bleeding, less injury, less complications, and higher safety.Moreover, there are no additional costs compared with open operation.Thus, the technique is recommended for clinical applications.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Value of Humanized Nursing under Emergency Green Channel on Gastrointestinal Function Recovery in Patients with Acute Intestinal Obstruction after Operation

Acute intestinal obstruction (aio) is one of the most common surgical acute abdomens.Emergency green channel refers to a fast and efficient service system provided by hospitals for critically ill patients.It is the key to ensure that emergency patients receive timely, standardized, efficient and thoughtful medical services, improve the success rate of rescue, and reduce medical risks.Acute intestinal obstruction is mainly treated by surgery in the clinic.Previous reports have shown that the application of different nursing methods in the operation of acute intestinal obstruction has different effects on the results of surgical treatment.In this study, the clinical data of 80 patients with aio were retrospectively analyzed to explore the value of humanistic care under the emergency green channel in promoting the recovery of gastrointestinal function after aio surgery.

Journal: Emergency Medicine International (2023)
Publication types: Research Article;
USP21 Promotes the Progression of Nasopharyngeal Carcinoma by Regulating FOXM1

The purpose of this work was to explore the molecular mechanisms by which usp21 regulates nasopharyngeal carcinoma tumor growth and cancer cell stemness.In this study, the usp21 transcript data was obtained from tcga database.Then, q pcr and western blot tests revealed that, in contrast to normal tissue or normal nasopharyngeal epithelial cells, the expression of usp21 was greater in nasopharyngeal carcinoma tissues or cell lines, respectively.Cck-8 and ed u immunofluorescent staining assays revealed that usp21 promoted the proliferation of nasopharyngeal carcinoma cells.Meanwhile, scratch and transwell assays showed that usp21 facilitated migration and invasion of nasopharyngeal carcinoma cells.Sphere formation assay was performed on nasopharyngeal carcinoma cells after knockdown of usp21, which revealed that knockdown of usp21 inhibited the stemness profiles of nasopharyngeal carcinoma cells.Then, the western blot assays indicated that knockdown of usp21 in nasopharyngeal carcinoma cells would inhibit foxm1 expression, and overexpression of foxm1 could reverse the cell proliferation ability, cell migration and invasion ability, and cell stemness profiles.Finally, a nasopharyngeal xenograft model suggested that usp21 facilitated tumor growth in mice.These findings proved that usp21 promoted tumor growth and cancer cell stemness in nasopharyngeal carcinoma by regulating foxm1.

Journal: Stem Cells International (2023)
Publication types: Research Article;
Using Color Difference Compensation Method to Balance and Repair the Image of Art Design

In the case of complex illumination background, the image has fuzziness and chromatic aberration, which can improve the imaging effect of the image by white balance chromatic aberration compensation.The traditional method uses the contour feature fusion adaptive matching method to compensate the white balance under the complex illumination background, which leads to the good color difference compensation effect when the image pixel is low.A white balance color compensation algorithm for fuzzy chromatic aberration based on wavelet packet decomposition is proposed.The original image was denoised and filtered.The white balance characteristics of the image were analyzed and extracted based on the wavelet packet decomposition method, and the adaptive balance design was carried out to realize the white balance and color difference compensation of the art design chromatic aberration image.By using the known pixel information of the image block to be repaired, the statistical properties of the image block to be repaired are predicted, and the matching cost of the image block to be matched that meets the restriction conditions is calculated.By introducing the objective factor, the matching cost function is improved to balance the restoration process, and the unnatural problem caused by the repeated appearance of some image details in the restoration results is solved.The simulation results show that the method can effectively balance the color difference of the image, improve the aesthetic feeling of the image, and improve the performance of the detail features of the image.The peak signal‐to‐noise ratio is high.

Journal: Complexity (2021)
Publication types: Research Article;
The Role of Gender-Related Immune Genes in Childhood Acute Myeloid Leukemia

The study of immune genes and immune cells is highly focused in recent years.To find immunological genes with prognostic value, the current study examines childhood acute myeloid leukemia according to gender.The target database was used to gather the “m rna expression profile data” and relevant clinical data of children with aml.To normalize processing and find differentially expressed genes (deg) between male and female subgroups, the limma software package is utilized.We identified prognostic‐related genes and built models using lasso, multivariate cox, and univariate cox analysis.The prognostic significance of prognostic genes was then examined through the processing of survival analysis and risk score (rs) calculation.We investigated the connections between immune cells and prognostic genes as well as the connections between prognostic genes and medications.Finally, five immune genes from the target database have been identified.These immune genes are considerably correlated to the prognosis of male patients.

Journal: BioMed Research International (2022)
Publication types: Research Article;
A K-Means Clustering Algorithm for Early Warning of Financial Risks in Agricultural Industry

As the primary industry, agricultural industry is the basis of guaranteeing people’s basic life and national economic development.Agricultural industrial finance/financial is a weak link in the financial system, which seriously hinders the emergence of agricultural scale effect and the improvement in agricultural production efficiency.In order to find the financial risk of agricultural industry in time, this article proposes an agricultural industry financial risk early warning system based on improved k-means clustering algorithm.Because the traditional k-means algorithm is easy to fall into local optimization in the clustering process, the clustering effect is not reliable.In this article, the idea of immune cloning and particle swarm optimization location update is added to the grey wolf optimization algorithm.Grey wolf optimization algorithm and k-means algorithm are combined to solve the problem that k-means algorithm is easy to fall into local optimization.In the experimental part, through comparative verification, it can be found that the prediction performance of this system is superior to other models.Its practical application value is higher.Therefore, choosing this system for early warning of agricultural industry finance can effectively improve the accuracy of early warning and provide guarantee for the economic development of agricultural industry.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Wireless Intelligent Sensor Network in Dynamic Environmental Monitoring of Archaeological Excavation Site

This paper intends to apply the intelligent wireless sensor network (iwsn) to the archaeological excavation site and make the dynamic site of archaeological excavation can be monitored intelligently in real‐time.This paper firstly discusses the structure and function of wireless sensor network (wsn).Secondly, according to the problem of limited dynamic monitoring of wsn, an iwsn is established.The dynamic environmental monitoring of archaeological excavation sites is achieved by using geographic information system (gis) and remote sensing technology combined with iwsn.Finally, this paper analyses the environmental monitoring results of the archaeological excavation site, the dynamic environmental monitoring location of the archaeological excavation site of the iwsn, and the simulation results of the intelligent wireless sensor network‐geographic information system (iwsn‐gis) in the dynamic environmental monitoring of the archaeological excavation site.The results show that the inverse distance to a power (idp) algorithm in temperature and humidity monitoring data on the overall downward trend, the algorithm performance is relatively stable, and the algorithm performance is better than the other two algorithms.The monitoring performance of iwsn‐gis system is better than that of iwsn system.It shows that with the increase in the communication distance of sensor nodes, the relative error of different monitoring systems for the dynamic monitoring position of the archaeological excavation site is decreasing.Iwsn‐gis can monitor the environment before, during, and after the archaeological site.This paper realizes the intelligent, scientific, and technological archaeology of archaeological excavation through iwsn, gis, and remote sensing image technology, and provides technical support for digital archaeology in archaeological research.

Journal: Journal of Sensors (2023)
Publication types: Research Article;
An Effective Machine Learning-Based Model for an Early Heart Disease Prediction

Heart disease (hd) has become a dangerous problem and one of the most significant mortality factors worldwide, which requires an expensive and sophisticated detection process.Most people are affected due to the failure of the heart which seriously threatens their lives due to high morbidity and mortality.Therefore, accurate prediction and diagnosis are needed for early prevention, detection, and treatment to reduce the death threats to human life.However, an early and accurate prediction of hd is still a challenging task to be addressed.In this work, we propose a machine learning‐based prediction model (mlb pm) that exploits a combination of the data scaling methods, the split ratios, the best parameters, and the machine learning algorithms for predicting hd.The performance of the proposed model is tested by performing experiments on a university of california irvine hd dataset to indicate the presence or absence of hd.The results show that the proposed mlb pm provides an accuracy of 96.7% when logistic regression, robust scaler, best parameter, and 70 : 30 as a split ratio of the dataset are considered.In addition, mlb pm outperforms other compared works in terms of accuracy.

Journal: BioMed Research International (2023)
Publication types: Research Article;
Analysis and Application of the Business English Translation Query and Decision Model with Big Data Corpus

This paper aims to build an english translation query and decision support model using big data corpus and applies it to business english translation.Firstly, the existing convolutional network is improved by using depth-separable convolution, and the input statements are mapped to the depth feature space.Secondly, the attentional mechanism is used to enhance the expressive ability of input sentences in deep feature space.Then, considering the sequential relationship, use long short-term memory (lstm) neural network as a decoder block to generate the corresponding translation of the input sentence.Finally, nonparametric metric learning module is used to improve the model in an end-to-end way.Wide range of experiments on the multiple corpora have shown the proposed model has better real-time performance while maintaining high precision in translation and query, and it has a certain practical application value.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Topological Coindices and Quantitative Structure-Property Analysis of Antiviral Drugs Investigated in the Treatment of COVID-19

Sars-co v-2 is a new strain of coronavirus family that has never been previously detected in humans.This has grown into a huge public health issue that has affected people all around the world.Presently, there is no specific antiviral treatment for covid-19.To tackle the outbreak, a number of drugs are being explored or have been utilized based on past experience.A molecular descriptor (or topological index) is a numerical value that describes a compound’s molecular structure and has been successfully employed in many qspr/qsar investigations to represent several physicochemical attributes.In order to determine topological characteristics of graphs, coindices (topological) take nonadjacent pair of vertices into account.In this study, we introduced co m-polynomial and numerous degree-based topological coindices for several antiviral medicines such as lopinavir, ritonavir remdesivir, hydroxychloroquine, chloroquine, theaflavin, thalidomide, and arbidol which were studied using the co m-polynomial approach.In the qspr model, the linear regression approach is used to analyze the relationships between physicochemical properties and topological coindices.The findings show that the topological coindices under investigation have a substantial relationship with the physicochemical properties of possible antiviral medicines in question.As a result, topological coindices may be effective tools for studying antiviral drugs in the future for qspr analyses.

Journal: Journal of Chemistry (2022)
Publication types: Research Article;