syedzayyan/paper_mill_benchmark huggingface dataset:
Application of Microspectral Imaging in Motor and Sensory Nerve Classification

It aimed to explore the application of the microscopic hyperspectral technique in motor and sensory nerve classification.Methods.The self-developed microscopic hyperspectral acquisition system was applied to collect the data of anterior and posterior spinal cord sections of white rabbits.The joint correction algorithm was employed to preprocess the collected data, such as noise reduction.On the basis of pure linear light source index, a new pixel purification algorithm based on cross contrast was proposed to extract more regions of interest, which was used for feature extraction of motor and sensory nerves.Besides, the ml algorithm was employed to classify motor and sensory nerves based on feature extraction results.Results.The joint correction algorithm was adopted to preprocess the data collected by the microscopic hyperspectral technique, so as to eliminate the influence of the incident light source and the system and improve the classification accuracy.The axon and myelin spectrum curves of the two kinds of nerves in the stained specimens had the same trend, but the values of all kinds of spectrum of sensory nerves were higher than those of motor nerves.However, the myelin sheath spectrum curves of motor nerves in the unstained specimens were greatly different from the curves of sensory nerves.The axon spectrum curves had the same trend, but the axon spectrum values of sensory nerves were higher than those of motor nerves.The ml algorithm had high accuracy and fast speed in motor and sensory nerve classification, and the classification effect of stained specimens was better than that of unstained specimens.Conclusion.The microscopic hyperspectral technique had high feasibility in sensory and motor nerve classification and was worthy of further research and promotion.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Application of Isothermal Signal Amplification Technique in the Etiological Diagnosis of Gonorrhea and Drug Resistance Gene Detection

Isothermal signal amplification technique is developed based on the rolling ring amplification mechanism of cyclic dna molecules in nature.This technique plays an extremely beneficial role in gonorrhea pathogen identification and drug resistance gene detection.Aims: this study analyzes the isothermal signal amplification techniques in the etiological diagnosis of gonorrhea and drug resistance gene detection.Materials and methods: urethral, cervical secretion, or prostatic fluid samples from 322 cases of gonorrhea collected from january 2018 to december 2021 at the std clinic of our hospital dermatology department were selected for direct smear examination and gonococcal culture examination; dna was extracted from urethral, cervical secretion, or prostatic fluid samples and then used for pathogen identification by sat assay and rolling loop nucleic acid amplification technique, smear examination and pathogen culture examination methods, sat assay, and isothermal signal amplification technique for comparative sensitivity and specificity analysis.Results: the highest rate of gonorrhea positivity was for the urine rolling loop nucleic acid amplification technique, followed by the swab rolling loop nucleic acid amplification technique, and the lowest rate of gonorrhea positivity was for the urine sat test.The difference in the positivity rate between the two urine testing methods was statistically significant ( p &lt; 0.05 ).The highest sensitivity of the urine rolling loop nucleic acid amplification technique method for the detection of gonorrhea pathogens and the lowest sensitivity of the urine sat method were statistically significant ( p &lt; 0.01 ).The differences in sensitivity and specificity between the swab rolling loop nucleic acid amplification technique and the swab sat method were not statistically significant ( p &gt; 0.05 ).Roc curves were plotted based on sensitivity and specificity, with swab sat assay ( a u c = 0.998 ) &gt; rolling loop nucleic acid amplification technique ( a u c = 0.981 ).Comparing the negative rates of urine and swab rolling loop nucleic acid amplification technique and urine sat assay, the differences were not statistically significant ( p &gt; 0.05 ).Conclusion: the isothermal signal amplification technique improves the shortcomings of gonorrhea pathogen identification means and drug resistance gene detection methods, with good detection sensitivity and specificity, simple operation, low price, and easy promotion, which has obvious advantages in clinical applications and epidemiological studies.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Application of Digital Orthopedic Technology in Orthopedic Trauma

In order to solve the limitation of auxiliary treatment means in the process of orthopedic trauma surgery, and further improve the effective integration of orthopedic trauma clinical surgery and computer technology, a new orthopedic trauma auxiliary treatment means based on digital orthopedic technology was proposed with the aid of virtual digital technology.The method builds a 3d model of fracture fragments through 3d orthopedic modeling and obtains a high-quality 3d model through processing.Later clinical tests verify the feasibility of this auxiliary treatment method.The test results show that the precision of the 3d reconstruction model based on custom option fitting is higher than that based on optimal option fitting, and the precision difference is within 0.2%.This result also indicates that the 3d model obtained by 3d reconstruction has higher accuracy.The results show that three-dimensional finite element modeling technology can accurately simulate the stress of the spine of orthopedic patients and can reduce the incidence of complications through preoperative diagnosis, curative effect prediction, and trauma surgery, which has a good aid for postoperative recovery.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Application of a Remotely Controlled Artificial Intelligence Analgesic Pump Device in Painless Treatment of Children

In order to effectively improve the application of analgesic pump devices in the treatment of children, a method based on remote control artificial intelligence is proposed.100 children with dental pulpitis who were treated in a hospital from december 2018 to december 2020 were selected as the research subjects; they were randomly divided into control group and observation group by an equidistant sampling method, with 50 cases in each group.Children in the control group were given articaine and adrenaline anesthesia, and the observation group was treated with articaine and adrenaline combined with a computer‐controlled anesthesia system, the anesthesia pain degree and satisfaction degree of the two groups of children were observed and compared.The results showed that the pain score in anesthesia and intraoperative pain score in the observation group was significantly lower than that in the control group, and the differences were statistically significant ( p &lt; 0.05).The total satisfaction of 96.6% patients in the observation group was significantly higher than that in the control group (84.7%) and the difference was statistically significant ( p &lt; 0.05).There were no serious complications in both groups.The application of the computer anesthesia system combined with articaine adrenaline in the painless treatment of children’s dental pulp proved to have better effects, the treatment compliance is higher, and it is worthy of clinical promotion.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Clinical Study;
Application Effect of Cluster-Based Care in Patients with Hypertensive Disorders of Pregnancy and Osteoarthritis

To explore the application effect of cluster-based care in patients with hypertensive disorders of pregnancy and osteoarthritis.Methods.The clinical data of 60 patients with hypertensive disorders of pregnancy and osteoarthritis in our hospital were retrospectively analyzed, among which those receiving routine care from january 2020 to december 2020 were grouped into the control group (30 patients), and those receiving cluster-based care from january 2021 to january 2022 were grouped into the research group (30 patients).Psychological status, care satisfaction, and pregnancy outcomes were compared between the two groups.Results.After intervention, self-rating anxiety scale (sas) and self-rating depression scale (sds) scores in the research group were lower than those in the control group ( p &lt; 0.05 ).There was no statistical significance in the difference of the modes of delivery between the two groups ( χ 2 = 1.763 , p &gt; 0.05 ).Patients in the research group had a lower incidence of perinatal complications than those in the control group ( χ 2 = 5.689 , p &lt; 0.05 ).And the satisfaction rate of care in the research group (93.33% vs 70%) was higher than that in the control group ( χ 2 = 4.238 , p &lt; 0.05 ).Conclusion.Cluster-based care can reduce patients’ negative mood, increase their satisfaction, and improve the maternal and infant outcomes.This type of care offers better quality care measures for patients with pregnancy hypertension and osteoarthritis, and has a wide clinical application prospect.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Anesthesia, Sedation, and Unplanned Extubation of Tracheal Intubation in Children with Severe Pneumonia

We randomly divided 200 children with severe pneumonia who met the indications for tracheal intubation into 2 groups in this prospective study.One group that received dexmedetomidine for sedation was recorded as the dexmedetomidine group (n = 100), and the group that received midazolam for sedation was recorded as the midazolam group (n = 100).We compared the anesthesia sedation scores, time to fall asleep, time to wake up from anesthesia, related hemodynamic parameters, and adverse reactions between the two groups of children.The failure mode and effect analysis method (fmea) was also used to investigate the causes of unplanned extubation (uex) of tracheal intubation in 32 children with severe pneumonia.Our conclusion is as follows: (1) compared with midazolam, the comprehensive effect of dexmedetomidine on children with severe pneumonia undergoing tracheal intubation for anesthesia and sedation is better, it can effectively shorten the anesthesia induction time and the recovery time after stopping the drug, and there are few adverse reactions, which is worthy of application and promotion.(2) uex is an important risk factor in the monitoring and nursing of children with severe pneumonia tracheal intubation, and the nursing method of pdca cycle management is particularly important for them.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Clinical Study;
Analysis on Value of Continuous Nursing Based on WeChat in Improving Healthy Quality of Life and Self-Management Behavior of Patients with Diabetic Nephropathy

To explore the value of continuous nursing (cn) based on we chat in improving healthy quality of life and self-management behavior of patients with diabetic nephropathy (dn).Methods.A total of 100 patients with dn who were treated in our hospital from november 2019 to january 2020 were selected.Thereinto, 54 patients who received cn based on we chat were considered as the research group, and 46 patients who received the routine nursing intervention were considered as the control group.Peripheral blood samples were collected before nursing intervention (t0), 1 month after intervention (t1), and 2 months after intervention (t2) to test blood glucose, blood lipid, and renal function.Exercise of self-care agency (esca) scale and general self-efficacy scale (gses) was conducted to evaluate patients’ self-management ability, and a short-form 36-item health survey (sf-36) was conducted to evaluate their quality of life.Finally, the treatment compliance and satisfaction of patients were investigated.Results.There was no marked difference in blood glucose, blood lipid, and renal function between groups at t0 ( p &gt; 0.05 ), but the research group was better than the control group at t1 and t2 ( p &lt; 0.05 ).After the nursing intervention, the scores of esca, gses, and sf-36 in the research group were higher ( p &lt; 0.05 ).In addition, the treatment compliance rate and satisfaction of the research group were also higher.Conclusion.Cn based on we chat can effectively improve the self-management behavior and quality of life of dn patients, which is extremely suitable for such chronic diseases with extremely long treatment cycles and can provide a more effective guarantee for their recovery.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Analysis of the Role and Mechanism of ZEB1 in Regulating Cervical Carcinoma Progression via Modulating PD-1/PD-L1 Checkpoint

Cervical carcinoma (cc) is a common and highly malignant tumor in women.The involvement of zinc finger e-box binding homeobox 1 (zeb1) in many kinds of tumors has been well-documented; however, its role and mechanism in cc remain to be clarified.Objective.This study investigated the mechanism of zeb1 in modulating the growth and metastasis of cc cells.Methods.The expression of zeb1 in cc tissues and adjacent normal counterparts was determined by reverse transcription-polymerase chain reaction (rt-pcr).The correlation between zeb1 and patient clinicopathological indexes was analyzed.In vitro, gain and loss functions of zeb1 were performed in c-33a and he la cell lines.The proliferation, migration, and invasion of cc cells were detected by cell counting kit-8 (cck-8) assay and transwell assay, respectively.The expression levels of apoptosis-related proteins such as bcl2-associated x (bax), b-cell lymphoma-2 (bcl2), and caspase-3, as well as epithelial-mesenchymal transition (emt)-associated proteins including e-cadherin, vimentin, and snail, were measured by western blotting.In addition, the targeting relationship between zeb1 and programmed death 1 (pd-1)/programmed cell death-ligand 1 (pd-l1) was predicted by bioinformatics and further verified by dual-luciferase reporter assay.Results.Zeb1 was significantly up-regulated in cc tissues compared with normal counterparts.Zeb1 overexpression promoted the migration, proliferation, and invasion of cc cells and inhibited apoptosis, while knocking down zeb1 contributed to the opposite effects.In addition, experiments on related mechanisms confirmed that zeb1 targeted the 3’eutr terminal of pd-1/pd-l1 and negatively regulated its expression.And an interaction between zeb1 and pd-1/pd-l1 was identified.Conclusion.Zeb1 can promote the proliferation and metastasis of cc cells via modulating the pd-1/pd-l1 checkpoint.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Analysis of the Relationship between the Expression Level of TTR and APOH and Prognosis in Patients with Colorectal Cancer Metastasis Based on Bioinformatics

The expression of ttr and apolipoprotein h (apoh) genes and their relationship with prognosis in patients with colorectal cancer (crc) metastasis by using bioinformatics analysis techniques are explored.The expression profiles of related genes in patients with crc metastasis are retrieved from the gene expression omnibus (geo) database.The core genes transthyretin (ttr) and apoh are screened by constructing protein‐protein interaction (ppi) network, and the corresponding patient data of 327 patients are extracted and included in the metastasis group.The ttr and apoh genes of 300 patients without crc metastasis are screened and included in the control group.The relationship between the expression levels of ttr and apoh and the clinicopathological parameters of patients with crc metastasis is analyzed.Kaplan–meier survival curve is drawn to observe the influence of overexpression and low expression of ttr and apoh on the prognosis and survival of patients in the metastatic group.Receiver operating characteristic (roc) curve is drawn to observe the prognostic efficacy of combined ttr and apoh detection in patients with crc metastasis.The experimental results show that bioassay can confirm the close relationship between ttr, apoh, and patients with crc metastasis.Regular detection of serum ttr and apoh expression can effectively assess the patient’s condition and take measures to improve the prognosis of the patients.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Analysis of the Mechanism of Ureproofing Technology and Postlaparoscopy on Patients with Urology and Infection

To analyze the effect of ureteroscopy and retrolaparoscopy on urinary calculi and infection.Method.A total of 64 patients with urinary calculi and infection who received treatment in our hospital from june 2018 to january 2018 were selected.According to the different treatment methods, they were divided into two groups: a control group and a study group.The study group was treated with laparoscopic ureteroscopy, and the control group was treated with ureteroscopy.The surgical results, complications, renal function, stress response, and inflammatory reaction were compared between the two groups.Results.Compared with the control group, the study group stone clearance rate was higher, the surgical time was shorter p &lt; 0.05 ; the incidence of complications in the study group (23.3%) was lower than that in the control group (5.9%) p &lt; 0.05 ; there was no significant difference in kidney function indicators before treatment p &gt; 0.05 ; after treatment, the scr, bun, ngal, and cys-c indicators of the two groups were significantly increased.Compared with the control group, the study group change was more obvious, and the difference was statistically significant p &lt; 0.05 ; after treatment, the two sets of stress response indicators were significantly increased, but relative to the control group, the study group stress response indicator was lower p &lt; 0.05 ; before treatment, there was no significant difference in inflammatory factors p &gt; 0.05 ; after treatment, the two sets of inflammatory factor levels were significantly increased, but relative to the control group, the study group was lower p &lt; 0.05 .Conclusion.In the clinical treatment of urinary stones, ureteroscopy technology and the laparoscopic technique have played an important role.But the laparoscopic technique is shorter, the stone clearance is higher, and the patient’s renal function can be improved, and the patient is postoperative.The stress reaction should be small.Therefore, in the clinical treatment of urinary stones and infection, laparoscopic technical treatment is worth promoting.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Clinical Study;
Analysis of the Efficacy and Safety of Pulpitis Treated with Different Root Canal Flushing Fluids Based on VAS and Temporomandibular Joint Function

Pulpitis is one of the common diseases indicated by the department of stomatology that is located in the tooth and contains abundant nerve vessels.In order to evaluate the pain degree and functional recovery of patients after treatment by visual analogue pain scale (vas) and temporomandibular joint function score, a retrospective analysis was performed on 128 patients diagnosed with pulpitis who received root canal treatment in the department of stomatology from january 2020 to march 2021.The results show that 3%na cl o combined with 0.9% sodium chloride injection can effectively relieve the pain degree of patients after treatment, and the antibacterial effect is significantly better than 3%h 2 o 2 combined with 0.9% normal saline.Meanwhile, it can effectively improve the temporomandibular joint function and reduce the recurrence rate, which has good clinical application value.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Analysis of the Effectiveness of the Nurse-Led “Outpatient-Ward-Home” Management Model in Chronic Kidney Patients

To investigate the application and effect of the nurse-led “outpatient-ward-home” management model in the care of patients with chronic kidney disease (ckd).Methods.120 patients with ckd admitted to our hospital between april 2020 and april 2021 were selected as trial subjects.All patients were divided into experimental and control groups according to the random number table method, with 60 cases in each group.The patients in the experimental group implemented the nurse-led “outpatient-ward-home” management model; the patients in the control group were given routine care and telephone follow-up.The self-rating anxiety scale (sas), self-rating depression scale (sds), pittsburgh sleep quality index (psqi) score, self-management scores, nutritional status, renal function indicators, and chronic renal failure quality of life scale (qlicd-crf2.0) were compared between the two groups before and 6 months after the intervention.Results.Before the intervention, there were no statistically significant differences between the control and experimental groups in sas, sds, psqi scores, self-management scores, qlicd-crf2.0 scores, body mass index (bmi), prealbumin (pab), albumin (alb), serum creatinine (scr), blood urea nitrogen (bun), and glomerular filtration rate (gfr) levels ( p &gt; 0.05 ).After 6 months of intervention, sas, sds, psqi scores, scr, bun, and gfr levels were lower in the experimental group than in the control group; self-management scores, qlicd-crf2.0 scores, bmi, pab, and alb levels were higher in the experimental group than in the control group ( p &lt; 0.05 ).Conclusion.The nurse-led “outpatient-ward-family” intervention model can improve the negative emotions and sleep disorders of ckd patients, enhance patients’ self-management ability, and to a certain extent, slow down the disease process and improve the quality of life.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Analysis of the Effect of Video-Guided Dance Creation for Young Children

Children’s dance is an important part of quality education for children, and it is also an important channel for children’s physical and mental development.Traditional children’s dance education adheres to the teaching method taught by teachers, and teachers insist on teaching progress.In order to improve the level and quality of children’s dance creation, this paper analyzes the effect of children’s dance creation under video guidance and discusses the integration strategies in children’s dance creation.Children’s dance education in the video teaching environment advocates the combination of online and offline teaching characteristics, and it is necessary to pay attention to the subjective initiative of students.At the same time, how to effectively use video teaching to improve aesthetic ability, effectively summarize online and offline resources to enhance educational efficiency, and make arrangements to strengthen the network.The quality of video-guided dance teaching is an era subject for the development of video-guided learning.Children’s dance education in the video teaching environment needs to focus on the development of teaching forms and the transformation of teaching thinking ability and guide students to strengthen their aesthetic ability in practical activities and teaching methods.

Journal: Mobile Information Systems (2022)
Publication types: Research Article;