syedzayyan/paper_mill_benchmark huggingface dataset:
The Effect of Healing Perception on the Visitors' Place Attachment and Their Loyalty toward a Metropolitan Park-Under the Aspect of Environmental Design.

Healing perception is considered to increase visitors' place attachment and loyalty.This research employed structural equation modeling (sem) to examine the structural relationship between healing perception, place attachment, environmental design, and visitors' loyalty to a place.The study investigated a metropolitan park in gaoxiong, taiwan, and collected 431 valid questionnaires on the site.The results showed that the environmental design affected the human perception of healing and place attachment, which substantially affected the visitors' loyalty toward the place.The healing perception powerfully impacted loyalty (0.76), which contained an indirect effect through place attachment and enhanced the direct impact of healing perception.Moreover, the environmental design had a capable direct effect (0.62) on visitors' loyalty through two full mediation paths: healing perception and place attachment.The study sheds light on designing a healing park that could enhance visitors' place attachment and strongly affect their loyalty to the park.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Assessment of CircRNA Expression Profiles and Potential Functions in Brown Adipogenesis.

Brown adipose tissue (bat) is specialized for energy expenditure, thus a better understanding of the regulators influencing bat development could provide novel strategies to defense obesity.Many protein-coding genes, mi rnas, and lnc rnas have been investigated in bat development, however, the expression patterns and functions of circ rna in brown adipogenesis have not been reported yet.This study determined the circ rna expression profiles across brown adipogenesis (proliferation, early differentiated, and fully differentiated stages) by rna-seq.We identified 3,869 circ rnas and 36.9% of them were novel.We found the biogenesis of circ rna was significantly related to linear m rna transcription, meanwhile, almost 70% of circ rnas were generated by alternative back-splicing.Next, we examined the cell-specific and differentiation stage-specific expression of circ rnas.Compared to white adipocytes, nearly 30% of them were specifically expressed in brown adipocytes.Further, time-series expression analysis showed circ rnas were dynamically expressed, and 117 differential expression circ rnas (decs) in brown adipogenesis were identified, with 77 upregulated and 40 downregulated.Experimental validation showed the identified circ rnas could be successfully amplified and the expression levels detected by rna-seq were reliable.For the potential functions of the circ rnas, go analysis suggested that the decreased circ rnas were enriched in cell proliferation terms, while the increased circ rnas were enriched in development and thermogenic terms.Bioinformatics predictions showed that decs contained numerous binding sites of functional mi rnas.More interestingly, most of the circ rnas contained multiple binding sites for the same mi rna, indicating that they may facilitate functions by acting as micro rna sponges.Collectively, we characterized the circ rna expression profiles during brown adipogenesis and provide numerous novel circ rnas candidates for future brown adipogenesis regulating studies.

Journal: Frontiers in genetics (2021)
Publication types: Journal Article
Liver enhancement during hepatobiliary phase after Gd-BOPTA administration: correlation with liver and renal function.

S to assess the influence of liver and renal function on liver relative enhancement during hepatobiliary phase mri after gd-bopta administration.Methods in this irb-approved retrospective cohort study, we included 326 patients who underwent gd-bopta-enhanced 1.5t liver mri, including hepatobiliary phase (hbp) acquired 90-150 min after injection, in two centres between jan 2016 and dec 2019.Liver signal intensity was measured on native and hbp phases and normalized to paraspinal muscles.Liver normalized relative enhancement (nre) in hbp was calculated and compared with e gfr, total serum bilirubin and hbp acquisition delay by means of spearman r correlation test and mann-whitney u test.Results 221/326 patients received 0.05 mmol/kg gd-bopta (group a), whereas 105/326 received 0.1 mmol/kg (group b).Liver nre in hbp was significantly higher in group b than in group a (0.55vs.0.33, p 1.2 mg/dl showed significantly lower nre in hbp compared with those with total bilirubin ≤ 1.2 mg/dl (p 1.2 mg/dl.Key points • the degree of liver enhancement during hepatobiliary phase after gd-bopta administration has a negative correlation with total serum bilirubin level (r = - 0.32, p < 0.0001).• the degree of liver enhancement during hbp after gd-bopta administration is not significantly correlated with renal function and acquisition delay (comprised between 90 and 150 min after contrast injection).• 0.1 mmol/kg gd-bopta dose might be preferable in patients with increased total serum bilirubin levels.

Journal: European radiology (2021)
Publication types: Journal Article
Cyberbullying among adolescents in Turkey: the relationship between coping strategies and cyberbullying perpetration.

Cyberbullying is becoming a global threat with the ease of access to the internet.Although many studies addressed the relationship between coping strategies and cyber victimization, the role of coping strategies, protective or risk factors, on involvement in cyberbullying perpetration is unclear.Therefore, the present study aims to examine the effect of active, avoidant, and negative coping strategies and the sociodemographic variables (i.e., parents' education, gender, and family income) on cyberbullying perpetration behaviors.Method the study was conducted on 1032 adolescents (mean age = 16.01 years; range = 14-18 years), 608 (58.9%) were female, and 424 (41.1%) were male.Personal information form, cyberbullying scale, and coping scale for adolescents (the kidcope) were used in data collection.Multiple regression analysis was performed for data analysis.Results the study's findings revealed that active coping strategy (β = -.26, p .05), family income (β = .03, p > .05), and the father's education (β = .01, p > .05) were not predicting factors of cyberbullying perpetration behaviors.Conclusions the results are discussed in light of the relevant literature and presented some theoretical and practical implications.

Journal: Child and adolescent mental health (2023)
Publication types: Journal Article
Higher Phytohormone Contents and Weaker Phytohormone Signal Transduction Were Observed in Cold-Tolerant Cucumber.

Cucumbers (cucumis sativus l.) originated from the south asian subcontinent, and most of them are fragile to cold stress.In this study, we evaluated the cold tolerance of 115 cucumber accessions and screened out 10 accessions showing high resistance to cold stress.We measured and compared plant hormone contents between cold-tolerant cucumber ct90r and cold-sensitive cucumber ct57s in cold treatment.Most of the detected plant hormones showed significantly higher content in ct90r.To elucidate the role of plant hormones, we compared the leaf- and root-transcriptomes of ct90r with those of ct57s in cold stress treatment.In leaves, there were 1209 differentially expressed genes (degs) between ct90r and ct57s, while there were 703 in roots.These degs were not evenly distributed across the chromosomes and there were significant enrichments at particular positions, including q ltt6.2, a known qtl controlling cucumber cold tolerance.The go and kegg enrichment analysis showed that there was a significant difference in the pathway of plant hormone transductions between ct90r and ct57s in leaves.In short, genes involved in plant hormone transductions showed lower transcription levels in ct90r.In roots, the most significantly different pathway was phenylpropanoid biosynthesis.Ct90r seemed to actively accumulate more monolignols by upregulating cinnamyl-alcohol dehydrogenase (cad) genes.These results above suggest a new perspective on the regulation mechanism of cold tolerance in cucumbers.

Journal: Plants (Basel, Switzerland) (2022)
Publication types: Journal Article
Systems Bioinformatics Reveals Possible Relationship between COVID-19 and the Development of Neurological Diseases and Neuropsychiatric Disorders.

Coronavirus disease 2019 (covid-19) is associated with increased incidence of neurological diseases and neuropsychiatric disorders after infection, but how it contributes to their development remains under investigation.Here, we investigate the possible relationship between covid-19 and the development of ten neurological disorders and three neuropsychiatric disorders by exploring two pathological mechanisms: (i) dysregulation of host biological processes via virus-host protein-protein interactions (ppis), and (ii) autoreactivity of severe acute respiratory syndrome coronavirus 2 (sars-co v-2) epitopes with host "self" proteins via molecular mimicry.We also identify potential genetic risk factors which in combination with sars-co v-2 infection might lead to disease development.Our analysis indicated that neurodegenerative diseases (nds) have a higher number of disease-associated biological processes that can be modulated by sars-co v-2 via virus-host ppis than neuropsychiatric disorders.The sequence similarity analysis indicated the presence of several matching 5-mer and/or 6-mer linear motifs between sars-co v-2 epitopes with autoreactive epitopes found in alzheimer's disease (ad), parkinson's disease (pd), myasthenia gravis (mg) and multiple sclerosis (ms).The results include autoreactive epitopes that recognize amyloid-beta precursor protein (app), microtubule-associated protein tau (mapt), acetylcholine receptors, glial fibrillary acidic protein (gfap), neurofilament light polypeptide (nf l) and major myelin proteins.Altogether, our results suggest that there might be an increased risk for the development of nds after covid-19 both via autoreactivity and virus-host ppis.

Journal: Viruses (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Nutritional Value, Chemical Composition and Cytotoxic Properties of Common Purslane (Portulaca oleraceaL.) in Relation to Harvesting Stage and Plant Part.

Purslane (portulaca oleraceae l.) is a widespread weed, which is highly appreciated for its high nutritional value with particular reference to the content in omega-3 fatty acids.In the present study, the nutritional value and chemical composition of purslane plants in relation to plant part and harvesting stage were evaluated.Plants were harvested at three growth stages (29, 43 and 52 days after sowing (das)), while the edible aerial parts were separated into stems and leaves.Leaves contained higher amounts of macronutrients than stems, especially at 52 das.Α-tocopherol was the main isoform, which increased at 52 das, as well total tocopherols (values were in the ranges of 197-327 μg/100 g fresh weight (fw) and 302-481 μg/100 g fw, for α-tocopherol and total tocopherols, respectively).Glucose and fructose were the main free sugars in stems and leaves, respectively, whereas stems contained higher amounts of total sugars (values were ranged between 0.83 g and 1.28 g/100 g fw).Oxalic and total organic acid content was higher in leaves, especially at the last harvesting stage (52 das; 8.6 g and 30.3 g/100 g fw for oxalic acid and total organic acids, respectively).Regarding the fatty acid content, stems contained mainly palmitic (20.2-21.8%) and linoleic acid (23.02-27.11%), while leaves were abundant in α-linolenic acid (35.4-54.92%).Oleracein a and c were the major oleracein derivatives in leaves, regardless of the harvesting stage (values were in the ranges of 8.2-103.0 mg and 21.2-143 mg/100 g dried weight (dw) for oleraceins a and c, respectively).Cytotoxicity assays showed no hepatotoxicity, with gi50values being higher than 400 μg/m l for all the harvesting stages and plant parts.In conclusion, early harvesting and the separation of plant parts could increase the nutritional value of the final product through increasing the content of valuable compounds, such as omega-3 fatty acids, phenolic compounds and oleracein derivatives, while at the same time, the contents of anti-nutritional compounds such as oxalic acid are reduced.

Journal: Antioxidants (Basel, Switzerland) (2019)
Publication types: Journal Article
Biochemical characterization of a thermophilic exo-arabinanase from the filamentous fungus Rasamsonia emersonii.

Arabinan in plant cell wall constitutes a major source of arabinose and arabino-oligosaccharides in nature.Exo-α-l-1,5-arabinanases release arabinose or arabino-oligosaccharides from arabinan in an exo-acting manner and therefore contribute to arabinan degradation.In this study, an exo-α-l-1,5-arabinanase belonging to gh93 family was identified from the thermophilic filamentous fungus rasamsonia emersonii.The corresponding encoding gene (reabn93) was cloned from the r.Emersonii genome and heterologously expressed in pichia pastoris.The purified recombinant re abn93 exhibited the maximum activity at 70 °c and retained 70% of its activity after incubation at 70 °c for 3 h re abn93 had an acidic p h optimum (p h 4.0) but remained stable over a broad p h range (p h 3-9).The specific activity of re abn93 toward linear arabinan under optimal conditions was 466.08 u mg-1.Similar to the few other reported gh93 members, re abn93 degrades linear arabinan or arabino-oligosaccharides in an exo-acting manner with arabinobiose as the only hydrolytic product.Of note, re abn93 possessed remarkably better thermostability and higher specific activity compared to the only reported thermophilic counterpart in gh93, and therefore holds potential in relevant biotechnological applications.

Journal: Journal of bioscience and bioengineering (2022)
Publication types: Journal Article
A green photocatalytic-biosensor for colorimetric detection of pesticide (carbaryl) based on inhibition of acetylcholinesterase.

Carbaryl is a widely-used carbamate pesticide and the detection of its residues in environmental, food and clinical samples is of great importance.In this sturdy, we developed a green photocatalytic-biosensor based on double strand dna-sybr green i complex for sensitively colorimetric detection of carbaryl.This green photocatalytic-biosensor can oxidize 3,3',5,5'-tetramethylbenzidine (tmb) into blue ox-tmb.Meanwhile thiocholine is catalytically produced by acetylcholinesterase (ach e) to directly reduce blue ox-tmb into colorless tmb.But the activity of ach e will be suppressed by carbaryl, thus generating less thiocholine and resulting in more ox-tmb for colorimetric analysis.After the careful optimization of sensing conditions (2 μm for dna concentration, 50 × concentration for sybr green i, 10 min for illumination time), the lowest detectable concentration for carbaryl is 0.008 ng/m l with a linear response in the range of 0.01-0.25 ng/m l.In addition, this photocatalytic-biosensor has good selectivity over non-target chemicals (acetamiprid, atrazine, carbendazim, melamine, bisphenol a, estradiol).It also allows detection of pesticides in real samples verified by a standard hplc method.

Journal: Talanta (2022)
Publication types: Journal Article
Application of a Novel CVD TiN Coating on a Biomedical Co-Cr Alloy: An Evaluation of Coating Layer and Substrate Characteristics.

Titanium nitride (ti n) was deposited on the surface of a cobalt-chromium (co-cr) alloy by a hot-wall type chemical vapor deposition (cvd) reactor at 850 °c, and the coating characteristics were compared with those of a physical vapor deposition (pvd) ti n coating deposited on the same alloy at 450 °c.Neither coating showed any reactions at the interface.The face-centered cubic (fcc) structure of the alloy was changed into a hexagonal close-packed (hcp) phase, and recrystallization occurred over at 10 μm of depth from the surface after cvd coating.Characteristic precipitates were also generated incrementally depending on the depth, unlike the precipitates in the matrix of the as-cast alloy.On the other hand, the microstructure and phase of the pvd-coated alloy did not change.Depth-dependent nano-hardness measurements showed a greater increase in hardness in the recrystallization zone of the cvd-coated alloy than in the bulk center of the alloy.The cvd coating showed superior adhesion to the pvd coating in the progressive scratch test.The as-cast, pvd-coated, and cvd-coated alloys all showed negative cytotoxicity.Within the limitations of this study, cvd ti n coating to biomedical co-cr alloy may be considered a promising alternative to pvd technique.

Journal: Materials (Basel, Switzerland) (2020)
Publication types: Journal Article
Dexmedetomidine and sleep quality in mechanically ventilated critically ill patients: study protocol for a randomised placebo-controlled trial.

Introduction sleep deprivation, which is a common complication in the intensive care unit (icu), is associated with delirium and increased mortality.Sedation with gamma-aminobutyric acid agonists (propofol, benzodiazepine) results in significant disturbance of the sleep architecture.Dexmedetomidine is a lipophilic imidazole with an affinity for α2-adrenoceptors and it has sedative and analgesic properties.It has been reported to enhance sleep efficiency, thus sedate while preserving sleep architecture.Methods and analysis thirty consecutive patients are planned to be included, at the department of anesthesia and intensive care at the hospital of southwest jutland, denmark.The study is a double-blinded, randomised, controlled trial with two parallel groups (2:1 allocation ratio).Screening and inclusion will be done on day 1 from 8:00 to 16:00.Two 16 hours psg (polysomnography) recording will be done starting at 16:00 on day 1 and day 2.Randomisation is performed if the first recording is of acceptable quality, otherwise the patient is excluded before randomisation.Dexmedetomidine/placebo will be administered during the second recording from 18:00 on day 2 to 6:00 on day 3.Primary endpoint improvement of total sleep time and sleep quality of clinical significance determined by psg.Secondary endpoints sleep phases determined by psg.Daytime function and delirium determined by confusion assessment method-icu.Alertness and wakefulness determined by richmonde agitation sedation scale.The objective is to compare the effect of dexmedetomidine versus placebo on sleep quality in critical ill mechanically ventilated patients.Ethics and dissemination the trial investigate the potential benefit of dexmedetomidine on clinically relevant endpoints.If a beneficial effect is shown, this would have a large impact on future treatment of mechanically ventilated critically ill patients.Publication in peer-reviewed journal are plannedand the study has been approved by the national committee on health research ethics (id:s-20180214).Trial registration number eudra ct (2017-001612-11dk) and danish national committee on health research ethics (id:s-20180214).The study related to pre-results.

Journal: BMJ open (2022)
Publication types: Clinical Trial Protocol;Journal Article;Research Support, Non-U.S. Gov't
The Relative Efficacy of Seven Skeletal Muscle Relaxants. An Analysis of Data From Randomized Studies.

Low back pain (lbp) causes 2.6 million visits to u.s.Emergency departments (eds) annually.These patients are often treated with skeletal muscle relaxants (smrs).Objectives the goal of this study was to determine whether efficacy of smrs is associated with age, sex, or baseline lbp severity.Methods this was a planned analysis of data from 4 randomized studies of patients with acute nonradicular lbp.Patients were enrolled during an ed visit and followed-up 1 week later.The primary outcome was improvement in the roland-morris disability questionnaire (rmdq) between ed discharge and the 1-week follow-up.We compared the change in rmdq among 8 groups: placebo, baclofen, metaxalone, tizanidine, diazepam, orphenadrine, methocarbamol, and cyclobenzaprine.All patients also received a nonsteroidal anti-inflammatory drug.We performed analysis of variance to determine statistically significant differences between medications and linear regression to determine the association of age, sex, and baseline severity with the primary outcome.Results the mean improvement in rmdq per group was placebo 10.5 (95% confidence interval [ci] 9.5-11.5), baclofen 10.6 (95% ci 8.6-12.7), metaxalone 10.3 (95% ci 8.1-12.4), tizanidine 11.5 (95% ci 9.5-13.4), diazepam 11.1 (95% ci 9-13.2), orphenadrine 9.5 (95% ci 7.4-11.5), methocarbamol 8.1 (95% ci 6.1-10.1), and cyclobenzaprine 10.1 (95% ci 8.3-12).The between-group differences were not statistically significantly different.Results were similar regardless of age, sex, and baseline severity.Higher baseline rmdq was associated with greater clinical improvement (b coefficient 5.7, p < 0.01).Adverse medication effects were more common with cyclobenzaprine than with placebo (p < 0.01).Conclusions among patients in the ed with acute lbp treated with a nonsteroidal anti-inflammatory drug, smrs do not improve outcomes more than placebo.Neither age, sex, nor baseline impairment impacts these results.

Journal: The Journal of emergency medicine (2022)
Publication types: Journal Article
High levels of TIMP1 are associated with increased extracellular matrix stiffness in isocitrate dehydrogenase 1-wild type gliomas.

Glioma progression is accompanied with increased tumor tissue stiffness, yet the underlying mechanisms are unclear.Herein, we employed atomic force microscopy analysis to show that tissue stiffness was higher in isocitrate dehydrogenase (idh)-wild type gliomas than idh-mutant gliomas.Bioinformatic analyses revealed that tissue inhibitor of metalloproteinase-1 (timp1) was one of the preferentially upregulated genes in idh-wild type gliomas as compared to idh-mutant gliomas, and its higher expression indicated worse prognosis of glioma patients.Timp1 intensity determined by immunofluorescence staining on glioma tissues positively correlated with glioma tissue stiffness.Mechanistically, timp1 expression was positively correlated with the gene expression of two predominant extracellular matrix components, tenascin c and fibronectin, both of which were also highly expressed in idh-wild type gliomas.By introducing idh1-r132h-containing vectors into human idh1-wild type glioma cells to obtain an idh1-mutant cell line, we found that idh1 mutation increased the timp1 promoter methylation through methylation-specific pcr.More importantly, idh1-r132h mutation decreased both the expression of timp1, fibronectin, tenascin c, and the tumor tissue stiffness in idh1-mutant glioma xenografts in contrast to idh1-wild type counterparts.Moreover, timp1 knockdown in idh-wild type glioma cells inhibited the expression of tenascin c and fibronectin, and decreased tissue stiffness in intracranial glioma xenografts.Conclusively, we revealed an idh mutation status-mediated mechanism in regulating glioma tissue stiffness through modulating timp1 and downstream extracellular matrix components.

Journal: Laboratory investigation; a journal of technical methods and pathology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't