syedzayyan/paper_mill_benchmark huggingface dataset:
Survival outcomes of robotic radical hysterectomy for early stage cervical cancer: A 9-year study.

Recently, the results of a rct have raised concerns on the management of cervical cancer through a minimally invasive approach.This study reports on the outcomes of patients with early stage cervical cancer submitted to robotics.Methods retrospective review of a consecutive series of patients with an early cervical cancer treated with robotics at a single institution over a 9-year period.Results a total of 91 women were managed; 39 (41.1%) had cervical adenocarcinoma.One (1.1%) conversion to laparotomy and one (1.1%) intraoperative complication occurred.Five (5.5%) patients experienced postoperative (>g2) complications; 24 (26.4%) patients required further adjuvant therapies.After a median follow-up of 40.7 (3.8-96.6) months, the dfs and os were 90.4 (95%ci 85.3-95.6)% and 94.5 (95%ci 91.8-97.2)%, respectively.Conclusions according to the available literature, the survival outcomes of this series of rrh for ecc are not inferior to what recorded in the past by an open approach.

Journal: The international journal of medical robotics + computer assisted surgery : MRCAS (2019)
Publication types: Journal Article;Observational Study
HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice.

Regulatory t (treg) cells are essential to maintain immune homeostasis in the intestine and tregcell dysfunction is associated with several inflammatory and autoimmune disorders including inflammatory bowel disease (ibd).Efforts using low-dose (ld) interleukin-2 (il-2) to expand autologous tregcells show therapeutic efficacy for several inflammatory conditions.Whether ld il-2 is an effective strategy for treating patients with ibd is unknown.Recently, we demonstrated that ld il-2 was protective against experimental colitis in immune humanized mice in which human cd4+t cells were restricted to human leukocyte antigen (hla).Whether hla restriction is required for human tregcells to ameliorate colitis following ld il-2 therapy has not been demonstrated.Here, we show that treatment with ld il-2 reduced 2,4,6-trinitrobenzensulfonic acid (tnbs) colitis severity in nod.prkdcscid il2rg-/-(nsg) mice reconstituted with human cd34+hematopoietic stem cells.These data demonstrate the utility of standard immune humanized nsg mice as a pre-clinical model system to evaluate therapeutics targeting human tregcells to treat ibd.

Journal: Frontiers in immunology (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Skin tape proteomics identifies pathways associated with transepidermal water loss and allergen polysensitization in atopic dermatitis.

Atopic dermatitis (ad) and food allergy (fa) are associated with skin barrier dysfunction.Objective skin biomarkers are needed for skin barrier interventions studies.Methods in this study, skin tape strip (sts) samples were collected from nonlesional skin of 62 children in ad fa+, ad fa-, and nonatopic groups for mass spectrometry proteomic analysis.Transepidermal water loss and allergic sensitization were assessed.Sts proteomic analysis results were validated in an independent cohort of 41 adults with ad with and without fa versus nonatopic controls.Results a group of 45 proteins was identified as a principal component 1 (pc1) with the highest expression in ad fa+ stss.This novel set of sts proteins was highly correlative to skin transepidermal water loss and allergic sensitization.Pc1 proteins included keratin intermediate filaments; proteins associated with inflammatory responses (s100 proteins, alarmins, protease inhibitors); and glycolysis and antioxidant defense enzymes.Analysis of pc1 proteins expression in an independent adult ad cohort validated differential expression of sts pc1 proteins in the skin of adult patients with ad with the history of clinical reactions to peanut.Conclusions sts analysis of nonlesional skin of ad children identified a cluster of proteins with the highest expression in ad fa+ children.The differential expression of sts pc1 proteins was confirmed in a replicate cohort of adult ad patients with fa to peanut, suggesting a unique sts proteomic endotype for ad fa+ that persists into adulthood.Collectively, pc1 proteins are associated with abnormalities in skin barrier integrity and may increase the risk of epicutaneous sensitization to food allergens.

Journal: The Journal of allergy and clinical immunology (2020)
Publication types: Clinical Trial;Journal Article;Research Support, N.I.H., Extramural;Validation Study
Screen-printed electrode-based biosensors modified with functional nucleic acid probes and their applications in this pandemic age: a review.

Electrochemical methodology has probably been the most used sensing platform in the past few years as they provide superior advantages.In particular, screen-printed electrode (spe)-based sensing applications stand out as they provide extraordinary miniaturized but robust and user-friendly detection system.In this context, we are focusing on the modification of spe with functional nucleic acid probes and nanostructures to improve the electrochemical detection performance in versatile sensing applications, particularly in the fight against the covid-19 pandemic.Aptamers are immobilized on the electrode surface to detect non-nucleic acid targets and complementary probes to recognize and capture nucleic acid targets.In a step further, spe-based biosensors with the modification of self-assembled dna nanostructures are emphasized as they offer great potential for the interface engineering of the electrode surface and promote the excellent performance of various interface reactions.By equipping with a portable potentiostat and a smartphone monitoring device, the realization of this spe-based miniaturized diagnostic system for the further requirement of fast and poc detection is revealed.Finally, more novel and excellent works are previewed and future perspectives in this field are mentioned.

Journal: Analytical methods : advancing methods and applications (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't
Female survivors of intimate partner violence and risk of depression, anxiety and serious mental illness.

Internationally, intimate partner violence (ipv) cohorts have demonstrated associations with depression and anxiety.However, this association has not yet been described in a uk population, nor has the association with serious mental illness (smi).Aims to explore the relationship between ipv exposure and mental illness in a uk population.Method we designed a retrospective cohort study whereby we matched 18 547 women exposed to ipv to 74 188 unexposed women.Outcomes of interest (anxiety, depression and smi) were identified through clinical codes.Results at baseline, 9174 (49.5%) women in the exposed group had some form of mental illness compared with 17 768 (24.0%) in the unexposed group, described as an adjusted odds ratio of 2.62 (95% ci 2.52-2.72).Excluding those with mental illness at baseline, 1254 exposed women (incidence rate 46.62 per 1000 person-years) went on to present with any type of mental illness compared with 3119 unexposed women (incidence rate 14.93 per 1000 person-years), with an a irr of 2.77 (95% ci 2.58-2.97).Anxiety (a irr 1.99, 95% ci 1.80-2.20), depression (a irr 3.05, 95% ci 2.81-3.31) and smi (a irr 3.08, 95% ci 2.19-4.32) were all associated with exposure to ipv.Conclusions ipv remains a significant public health issue in the uk.We have demonstrated the significant recorded mental health burden associated with ipv in primary care, at both baseline and following exposure.Clinicians must be aware of this association to reduce mental illness diagnostic delay and improve management of psychological outcomes in this group of patients.

Journal: The British journal of psychiatry : the journal of mental science (2020)
Publication types: Journal Article
Gold nanoparticle-based enhanced lateral flow immunoassay for detection of Cronobacter sakazakii in powdered infant formula.

Cronobacter sakazakii is an opportunistic foodborne pathogen that can infect newborns through powdered infant formula (pif).In this study, we developed a novel enhanced lateral flow immunoassay (lfa) with enhanced sensitivity for detection of c.Sakazakii in pif by the naked eye.The proposed strategy for signal enhancement of the traditional lfa used concentrated gold nanoparticles (au np) as the enhancer to conjugate with capture antibodies, which could increase the immobilized capture antibodies concentration at the detection zone to improve capture efficiency.Besides, the detection signal was further amplified by accumulated au np as the c.Sakazakii labeled with au np probes was captured by antibodies conjugated with enhancer at the test line.We also studied the effect of different concentrations of capture antibodies and concentrated au np on detection performance, and found that 2.2 mg/m l of capture antibodies and 0.06 n m concentrated au np were the optimal combination that could avoid a false-positive signal and maximally amplify the detection signal of the enhanced lfa.Using this strategy, the detection sensitivity of the enhanced lfa was 103cfu/m l and improved 100-fold compared with traditional lfa.The strip was highly specific to c.Sakazakii, and the time for detection of c.Sakazakii in pif was shortened by 3 h.In summary, the enhanced lfa developed by the addition of concentrated au np as the enhancer can be used as a sensitive, rapid, visual qualitative and point-of-care test method for detecting target analytes.

Journal: Journal of dairy science (2018)
Publication types: Evaluation Study;Journal Article
Neutralizing monoclonal antibodies for COVID-19 treatment and prevention.

The sars-co v-2 pandemic has caused unprecedented global health and economic crises.Several vaccine approaches and repurposed drugs are currently under evaluation for safety and efficacy.However, none of them have been approved for covid-19 yet.Meanwhile, several n mabs targeting sars-co v-2 spike glycoprotein are in different stages of development and clinical testing.Preclinical studies have shown that cocktails of potent n mabs targeting the receptor binding site of sars-co v-2, as well as broad-n mabs targeting conserved regions within the virus spike, might be effective for the treatment and prophylaxis of covid-19.Currently, several clinical trials have started to test safety, tolerability, pks and efficacy of these n mabs.One paramount limitation for the use of n mabs in clinical settings is the production of large amounts of mabs and the high costs related to it.Cooperation among public and private institutions coupled with speed of development, rapid safety evaluation and efficacy, and early planning for scale-up and manufacture will be critical for the control of covid-19 pandemic.

Journal: Biomedical journal (2021)
Publication types: Journal Article;Review
Comparison of Smoking Cessation Program Registration, Participation, Smoking Cessation Medication Utilization, and Abstinence Rates Between Smokers With and Without Schizophrenia, Schizo-affective Disorder, or Bipolar Disorder.

Introduction people with serious mental illness (smi) are three times more likely to smoke and be heavy smokers than smokers without smi.Counseling combined with smoking cessation medication (scm) is the recommended treatment.However, until 2017, scm prescription for smi smokers was discouraged (fda black box warning).This study compared use of smoking cessation programs (scp) and scm between smokers with and without smi.Aims and methods data regarding scp and scm use were extracted from the database of a large hmo that offers free group and telephone scp.Scp registration, participation, completion, and abstinence rates between july 2013 and december 2019 were compared between smokers with and without smi, controlling for demographic and health variables.Results 48 000 smokers registered for a scp during the study period.Smokers with smi were 1.8 times more likely to register for a scp than smokers without smi.Smokers without smi were, however, 1.2 times more likely to start the scp, 1.5 times more likely to complete the scp, and 1.6 times more likely to have quit by the end of the program.The strongest factors predicting abstinence were scp completion and scm use.Smokers with smi were less likely to purchase scm, although their purchase rate increased after the black box warning was lifted.Conclusions smoking cessation programs and scm use should be encouraged in the smi population.Providing support during the quit attempt and adapting scp to the needs of smokers with smi, combined with scm prescription promotion, should improve abstinence.Implications smokers with serious mental illness (smi) were more likely to seek professional help to quit smoking than non-smi smokers, with over 30% achieving abstinence, discrediting healthcare professional beliefs that smi smokers don't want to and cannot quit.Smoking cessation program (scp) completion and smoking cessation medication (scm) utilization were the strongest predictors of abstinence.Smi smokers were more likely to drop out of scps and less likely to use scms.Providing support during the quit attempt and adapting scps to the needs of smokers with smi, combined with scm prescription promotion, should improve abstinence.

Journal: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Hyperglycemia affects neuronal differentiation and Nestin, FOXO1, and LMO3 mRNA expression of human Wharton's jelly mesenchymal stem cells of children from diabetic mothers.

Pregestational diabetes mellitus (pdm) during pregnancy constitutes an unfavorable embryonic and fetal development environment, with a high incidence of congenital malformations (cm).Neural tube defects are the second most common type of cm in children of diabetic mothers (cdm), who also have an elevated risk of developing neurodevelopmental disorders.The mechanisms that lead to these neuronal disorders in cdm are not yet fully understood.The present study aimed to know the effect of hyperglycemia on proliferation, neuronal differentiation percentage, and expression of neuronal differentiation m rna markers in human umbilical cord wharton's jelly mesenchymal stem cells (h ucwjmsc) of children from normoglycemic pregnancies (ngp) and pdm.We isolated and characterized h ucwjmsc by flow cytometry, immunofluorescence, rt-pcr and were induced to differentiate into adipocytes, osteocytes, and neurons.Proliferation assays were performed to determine the doubling time, and nestin, tubb3, foxo1, kcnk2, lmo3, and map2 m rna gene expression was assessed by semiquantitative rt-pcr.Hyperglycemia significantly decreased proliferation and neuronal differentiation percentage in ngp and pdm cells treated with 40 m m d-glucose.Nestin m rna expression decreased under control glycemic conditions, while foxo1, kcnk2, lmo3, and map2 m rna expression increased during neuronal differentiation in both ngp and pdm cells.On the other hand, under hyperglycemic conditions, nestin was significantly decreased in cells from ngp but not in cells from pdm, while m rna expression of foxo1 and lmo3 was significantly increased in cells from ngp, but not in cells from pdm.We found evidence that maternal pdm, with hyperglycemia in culture, affects the biological properties of fetal cells.All these results could be part of fetal programming.

Journal: Biochemical and biophysical research communications (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Patellar Tendon Injury: A Bibliometric Analysis of the Most-Cited Articles Demonstrates Relatively High Overall Level of Evidence.

To identify and analyze the 50 most-cited articles in patellar tendon injury research.Methods the isi web of science and scopus databases were used to conduct a search for articles pertaining to patellar tendon injury.For the top 50 most-cited articles, bibliometric data (title, first and senior author, citation count, journal, publication year, citation density, country of origin, level of evidence [loe]) and topic of article were recorded.Results the mean number of citations was 172.0 ± 88.2 (range 101-546).There was a statistically significant correlation between publication year and citation density (r = 0.61, p < .01).The earliest article was the third most-cited article (362 citations), published by blazina et al.In 1973, which discussed the epidemiology of patellar tendinopathy.The first and second most-cited articles (546 and 466 citations, respectively) covered surgical outcomes of patellar tendinopathy and prevalence of patellar tendinopathy among elite athletes.A total of 14 articles (28%) discussed nonoperative management, whereas only 5 articles discussed surgical management (10%).The most frequent loe category was a loe of iv (n = 18, 36%), but 19 studies (38%) were loe i or loe ii.Conclusions among the top 50 most-cited studies regarding patellar tendon injury, a relatively high number were of a high loe (19 level i or ii, 38%), affirming that these articles in patellar tendon injury research are not only influential, but also of high-quality evidence.Clinical relevance this bibliometric analysis provides an efficient tool for educators, researchers, and evidence-based practitioners to identify and evaluate the most influential articles in patellar tendon injury research.

Journal: Arthroscopy, sports medicine, and rehabilitation (2022)
Publication types: Journal Article
Complaints of reduced cognitive functioning during perimenopause: a cross-sectional analysis of the Japan Nurses' Health Study.

Many women experience various symptoms during the period of menopausal transition, including complaints of reduced cognitive functioning.However, these complaints are not necessarily recognized as core menopausal symptoms.In this study, we sought to characterize subjective complaints of reduced cognitive functioning by analyzing cross-sectional data from the japan nurses' health study (jnhs).Methods the jnhs 4-year follow-up questionnaire containing a 21-item climacteric symptom checklist, which included a question about "poor memory or forgetfulness", was mailed between 2005 and 2011 to all jnhs participants, regardless of their age at the time of the survey.We estimated the prevalence of slight and severe complaints in 5-year age-groups.We used principal component analysis to explore the underlying factors among the 21 symptoms during the menopausal transition period in women aged 45-54 years at the time of the survey.We also examined risk factors for complaints using multivariable modified poisson regression analysis.Results in total, 12,507 women responded to the 4-year survey.The mean age at the time of the 4-year survey was 46.5 years (range 27-82)."poor memory or forgetfulness" showed a peak prevalence of 81.7% (severe 27.9%; slight 53.8%) at 50-54 years, and gradually decreased after 55 years.Principal component analysis indicated that "poor memory or forgetfulness" belonged to somatic symptoms and was close to psychological symptoms in women aged 45-54 years.In women aged 45-54 years, the complaint was also significantly associated with hot flashes and sweats.Multivariable modified poisson regression analysis showed that menopausal status (uncertain and postmenopausal), less sleep (sleep of < 5 h and sleep of 5- < 6 h), night-shift work, and severe vasomotor symptoms (vms) were significantly associated with the prevalence of severe complaints of reduced cognitive functioning in women aged 45-54 years.Conclusions we found that prevalence of "poor memory or forgetfulness" was highest during the menopausal transition period and among perimenopausal women.This subjective complaint was associated with somatic, psychological complaints and vms.It may be useful for women with cognitive problems in the transition period to consider management of comorbid menopausal symptoms.

Journal: Women's midlife health (2022)
Publication types: Journal Article
Cone-beam computed tomography for trauma.

Radiographic imaging is critical in helping guide treatment of critically injured patients.Cone-beam computed tomography is an axial imaging technique available from fixed imaging systems found in hybrid operating rooms.It can be used to provide focused studies of specific anatomical regions, where patients cannot undergo conventional multidetector computed tomography.This includes non-contrast-enhanced evaluation of the intracranial contents and vascular imaging throughout the body.There are a number of advantages and disadvantages to cone-beam computed tomography, but these are not widely discussed within the trauma literature.This narrative review article presents the initial practical experience of this novel imaging modality.Level of evidence: review article, level iii.

Journal: The journal of trauma and acute care surgery (2020)
Publication types: Journal Article;Review
Chitosan-Coated Liposomes: The Strategy to Reduce Intestinal Toxicity and Improve Bioavailability of Oral Vinorelbine.

In recent years, the oral administration of vinorelbine has gradually replaced intravenous administration in the treatment of several types of tumors.Even though the risk of phlebitis is avoided with oral administration, oral vinorelbine is still not a highly patient-compliant route due to the severe gastrointestinal toxicity.Vinorelbine-loaded liposomes with high encapsulation efficiency and suitable particle size were prepared using the ammonium sulfate gradient method.Chitosan-coated liposomes showed the slowest in vitro release compared to uncoated liposomes and vinorelbine solution.No damage was observed in the intestinal epithelial cells of mice orally administered with coated vinorelbine liposomes due to the low presence of the free drug in the gastrointestinal tract and the ld50was increased from 129.83 to 182.25 mg/kg compared to oral vinorelbine solution.In addition, the positive surface potential of chitosan-coating endowed liposomes with mucosal adhesive function, delaying the time to reach the peak plasma concentration of vinorelbine from 1 to 4 h after administration.And bioavailability was increased to 2.1-fold compared to vinorelbine solution.In short, a new strategy to address the severe gastrointestinal side effects of oral vinorelbine has been developed.

Journal: AAPS PharmSciTech (2022)
Publication types: Journal Article