syedzayyan/paper_mill_benchmark huggingface dataset:
CTP Synthase 2 FromArabidopsis thalianaIs Required for Complete Embryo Development.

Pyrimidinede novosynthesis is an essential pathway in all organisms.The final and rate-limiting step in the synthesis of the nucleotide cytidine triphosphate (ctp) is catalyzed by ctp synthase (ctps), and arabidopsisharbors five isoforms.Single mutant lines defective in each one of the four isoforms do not show apparent phenotypical alterations in comparison to wild-type plants.However,arabidopsislines that contain t-dna insertions in the ctps2gene were unable to produce homozygous offspring.Here, we show that ctps2exhibits a distinct expression pattern throughout embryo development, and loss-of-function mutants are embryo lethal, as siliques from+/ctps2plants contained nearly 25% aborted seeds.This phenotype was rescued by complementation with ctps2under control of its endogenous promoter.Ctps2::gfp lines revealed expression only in the tip of columella cells in embryo root tips of the heart and later stages.Furthermore,ctps2expression in mature roots, most pronounced in the columella cells, shoots, and vasculature tissue of young seedlings, was observed.Filial generations of+/ctps2plants did not germinate properly, even under external cytidine supply.During embryo development, the ctps2expression pattern resembled the established auxin reporter dr5::gfp.Indeed, the cloned promoter region we used in this study possesses a repeat of an auxin response element, and auxin supply increased ctps2expression in a cell-type-specific manner.Thus, we conclude that ctps2 is essential for ctp supply in developing embryos, and loss-of-function mutants in ctps2are embryo lethal.

Journal: Frontiers in plant science (2021)
Publication types: Journal Article
Dietary ferulic acid supplementation improved cottonseed meal-based diet utilization by enhancing intestinal physical barrier function and liver antioxidant capacity in grass carp (Ctenopharyngodon Idellus).

The present study explored the effects of ferulic acid (fa) supplementation in cottonseed meal (csm)-based diets on grass carp growth performance, feed utilization, liver antioxidation status, and intestinal physical barrier function.Here, four experimental diets supplemented with fa at graded levels (0, 50, 100 and 200 mg/kg) and csm as the main protein source (384.6 g/kg feed) for an 8-week feeding trial.Our results indicated that 200 mg/kg fa supplementation in a csm-based diet significantly improved growth performance [including final body weight (fbw), weight gain rate, and specific growth rate] and feed utilization [including feed conversion ratio and protein efficiency ratio] in grass carp (p< 0.05).The results of polynomial regression analysis based on fbw recommended that the optimal dose for fa supplementation was 204 mg/kg.Compared with that no fa supplementation, 200 mg/kg fa supplementation significantly reduced liver malondialdehyde levels and increased glutathione reductase activities (p< 0.05) and 100 mg/kg fa supplementation significantly increased liver total superoxide dismutase activities and reduced blood alanine transaminase levels (p< 0.05).Compared with the control group, 100 mg/kg fa supplementation also led to significantly increased m rna expression ofzo-1,zo-2,occludin,claudin-b,claudin-3,claudin-7a, andclaudin-12, encoding intestinal tight junction proteins (p< 0.05).Notably, fa supplementation could reduce lipid deposition by regulating bile acid (ba) secretion.In this study, 100 and 200 mg/kg fa supplementation significantly increased blood and liver total ba levels, respectively (p< 0.05); 100 mg/kg fa also significantly activated m rna expressions offxrandcyp7a1(p< 0.05).Furthermore, the whole-body composition results presented that fa treatment relieved lipid deposition, particularly 50 and 200 mg/kg fa supplementation (p< 0.05).Moreover, triglyceride and total cholesterol levels were significantly lower and high-density lipoprotein levels were significantly higher with 200 mg/kg fa supplementation than with no fa supplementation (p< 0.05).Taken together, the results indicated that fa may be a beneficial feed additive to boost fish growth performance and increase csm utilization.

Journal: Frontiers in physiology (2022)
Publication types: Journal Article
Global trends in lifespan inequality: 1950-2015.

Using data from the un world population prospects, we document global trends in lifespan inequality from 1950 until 2015.Our findings indicate that (i) there has been a sustained decline in overall lifespan inequality, (ii) adult lifespan variability has also declined, but some plateaus and trend reversals have been identified, (iii) lifespan inequality among the elderly has increased virtually everywhere, and (iv) most of the world variability in age-at-death can be attributed to within-country variability.Such changes have occurred against a backdrop of generalized longevity increases.Our analyses suggest that the world is facing a new challenge: the emergence of diverging trends in longevity and age-at-death inequality among the elderly around the globe-particularly in high-income areas.As larger fractions of the world population survive to more advanced ages, it will be necessary for national and international health planners to recognize the growing heterogeneity that characterizes older populations.

Journal: PloS one (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Lamplight Stabilization for GPS Rb Atomic Clocks via RF-Power Control.

Recent evidence indicates that the signal-in-space user-range-error (sis-ure) for gps is strongly influenced by the satellite atomic clock's rubidium (rb) lamplight intensity jumps.Following a proposal by bloom and bell, we have implemented rf-power control of an rf-discharge lamp of the type employed in rb atomic frequency standards (rafs).Since rb lamplight intensity jumps are mapped onto the clock's output frequency via the light-shift effect, stabilization of the rb light emitted by the lamp has the potential to significantly improve the rafs' long-term frequency stability, and hence the gps sis-ure.Here, we not only demonstrate that rf-power control of the discharge lamp is possible, but also that by employing such control the fluctuations in rb lamplight intensity can be reduced by orders of magnitude, providing a pathway for significant improvement in global navigation satellite systems.

Journal: IEEE transactions on ultrasonics, ferroelectrics, and frequency control (2018)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.
Lateralization of Brain Networks and Clinical Severity in Toddlers with Autism Spectrum Disorder: A HARDI Diffusion MRI Study.

Recent diffusion tensor imaging studies in adolescents and children with autism spectrum disorder (asd) have reported a loss or an inversion of the typical left-right lateralization in fronto-temporal regions crucial for sociocommunicative skills.No studies explored atypical lateralization in toddlers and its correlation with clinical severity of asd.We recruited a cohort of 20 subjects aged 36 months or younger receiving a first clinical diagnosis of asd (15 males; age range 20-36 months).Patients underwent diffusion mri (high-angular-resolution diffusion imaging protocol).Data from cortical parcellation were combined with tractography to obtain a connection matrix and diffusion indexes (di ) including mean fractional anisotropy (dfa ), number of tracts (dnum ), and total tract length (dttl ).A laterality index was generated for each measure, and then correlated with the autism diagnostic observation schedule-generic (ados-g) total score.Laterality indexes of dfa were significantly correlated with ados-g total scores only in two intrafrontal connected areas (correlation was positive in one case and negative in the other).Laterality indexes of dttl and dnum showed significant negative correlations (p < 0.05) in six connected areas, mainly fronto-temporal.This study provides first evidence of a significant correlation between brain lateralization of diffusion indexes and clinical severity in toddlers with a first diagnosis of asd.Significant correlations mainly involved regions within the fronto-temporal circuits, known to be crucial for sociocommunicative skills.It is of interest that all correlations but one were negative, suggesting an inversion of the typical left-right asymmetry in subjects with most severe clinical impairment.

Journal: Autism research : official journal of the International Society for Autism Research (2016)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
AIDEx - An Open-source Platform for Real-Time Forecasting Sepsis and A Case Study on Taking ML Algorithms to Production.

Sepsis, a dysregulated immune response to infection, has been the leading cause of morbidity and mortality in critically ill patients.Multiple studies have demonstrated improved survival outcomes when early treatment is initiated for septic patients.In our previous work, we developed a real-time machine learning algorithm capable of predicting onset of sepsis four to six hours prior to clinical recognition.In this work, we develop aidex, an open-source platform that consumes data as fhir resources.It is capable of consuming live patient data, securely transporting it into a cloud environment, and monitoring patients in real-time.We build aidex as an ehr vendor-agnostic open-source platform that can be easily deployed in clinical environments.Finally, the computation of the sepsis risk scores uses a common design pattern that is seen in streaming clinical informatics and predictive analytics applications.Aidex provides a comprehensive case study in the design and development of a production-ready ml platform that integrates with healthcare it systems.

Journal: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference (2020)
Publication types: Journal Article
Inflation versus filling-in: why we feel we see more than we actually do in peripheral vision.

Do we perceive fine details in the visual periphery?Here, we propose that phenomenology in the visual periphery can be characterized by aninflatedsense of perceptual capacity, as observers overestimate the quality of their perceptual inputs.Distinct from the well-known perceptual phenomenon of 'filling-in' where perceptual content is generated or completed endogenously, inflation can be characterized by incorrect introspection at the subjective level.The perceptual content itself may be absent or weak (i.e.Not necessarily filled-in), and yet such content is mistakenly regarded by the system as rich.Behaviourally, this can be reflected bymetacognitivedeficits in the degree to which confidence judgements track task accuracy, anddecisionalbiases for observers to think particular items are present, even when they are not.In two experiments using paradigms that exploit unique attributes of peripheral vision (crowding and summary statistics), we provide evidence that both types of deficits are present in peripheral vision, as observers' reports are marked by overconfidence in discrimination judgements and high numbers of false alarms in detection judgements.We discuss potential mechanisms that may be the cause of inflation and propose future experiments to further explore this unique sensory phenomenon.this article is part of the theme issue 'perceptual consciousness and cognitive access'.

Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences (2018)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
Aged dominant negative p38α MAPK mice are resistant to age-dependent decline in adult-neurogenesis and context discrimination fear conditioning.

A major aspect of mammalian aging is the decline in functional competence of many self-renewing cell types, including adult-born neuronal precursors.Since age-related senescence of self-renewal occurs simultaneously with chronic up-regulation of the p38mapkalpha (p38α) signaling pathway, we used the dominant negative mouse model for attenuated p38α activity (dn-p38αaf/+) in which thr180 and tyr182 are mutated (t→a/y→f) to prevent phosphorylation activation (dn-p38αaf/+) and kinase activity.As a result, aged dn-p38αaf/+mice are resistant to age-dependent decline in proliferation and regeneration of several peripheral tissue progenitors when compared to wild-type littermates.Aging is the major risk factor for non-inherited forms of alzheimer's disease (ad); environmental and genetic risk factors that accelerate the senescence phenotype are thought to contribute to an individual's relative risk.In the present study, we evaluated aged dn-p38αaf/+and wildtype littermates in a series of behavioral paradigms to test if p38α mutant mice exhibit altered baseline abnormalities in neurological reflexes, locomotion, anxiety-like behavior, and age-dependent cognitive decline.While aged dn-p38αaf/+and wildtype littermates appear equal in all tested baseline neurological and behavioral parameters, dn-p38αaf/+exhibit superior context discrimination fear conditioning.Context discrimination is a cognitive task that is supported by proliferation and differentiation of adult-born neurons in the dentate gyrus of the hippocampus.Consistent with enhanced context discrimination in aged dn-p38αaf/+, we discovered enhanced production of adult-born neurons in the dentate gyrus of dn-p38αaf/+mice compared to wildtype littermates.Our findings support the notion that p38α inhibition has therapeutic utility in aging diseases that affect cognition, such as ad.

Journal: Behavioural brain research (2017)
Publication types: Journal Article
Association of exposure to polycyclic aromatic hydrocarbons with inflammation, oxidative DNA damage and renal-pulmonary dysfunctions in barbecue makers in Southern Nigeria.

Multiple organ dysfunctions have been linked to exposure to polycyclic aromatic hydrocarbons (pah) and oxidative stress (os), oxidative dna damage, and inflammatory response to pah have been implicated.The biomarkers of os (malondialdehyde (mda), total plasma peroxide (tpp), total antioxidant capacity (tac), glutathione (gsh), nitric oxide (no), oxidative stress index (osi)); 8-hydroxy-2-deoxyguanosine (8-ohd g)); tumor necrosis factor-alpha (tnf-α)); 1-hydroxy pyrene (1-hop)), serum and urine creatinine, uric acid (ua), estimated glomerular filtration rate (e gfr) and peak expiratory flow rate (pefr) were assessed in barbecue makers.Methods one hundred barbecue makers and 50 controls were enrolled into the study.Serum and urine creatinine, ua, tac, mda, gsh, no and tpp were estimated by colorimetry, 8-ohd g and tnf-α by elisa, pefr using peak flow meter, 1-hop by hplc, e gfr and osi by calculation.Results barbecue makers had lower tac, pefr, and higher tnf-α and os compared to controls (p 5years compared to <5years (p <0.05).Increasing number of working hours was associated with higher no, lipid peroxidation, os and lower antioxidants in barbecue makers (p <0.05).Positive associations were observed between 1-hop and tpp (r=0.570, p=0.000), osi (r=0.299, p=0.035) and negative association between tac and tnf-α (r=-0.209, p=0.037), mda (r=-0.265, p=0.008) in barbecue makers.Conclusion increased lipid peroxidation, os, inflammation and depressed antioxidants and lung function observed in barbecue makers suggest increased risk of chronic lung conditions which may be associated with exposure to pah in barbecue fumes.

Journal: Reports of biochemistry & molecular biology (2022)
Publication types: Journal Article
Rational Pore Design of a Cage-like Metal-Organic Framework for Efficient C2H2/CO2Separation.

Considering the importance of c2h2in industry, it is of great significance to develop porous materials for efficient c2h2/co2separation.Besides the high selectivity, the c2h2adsorption capacity is another vital factor in c2h2/co2separation.However, the "trade-off" between these two factors is still perplexing.Rational pore design of metal-organic frameworks (mofs) has been proven to be an effective way to solve the above problem.In this work, we have appropriately combined three kinds of strategies in the design of the mof (fji-h33), i.e., the introduction of open metal sites, construction of cage-like cavities, and adjustment of moderate pore size.As anticipated,fji-h33exhibits both outstanding c2h2adsorption capacity and high c2h2/co2selectivity.At 298 k and 100 k pa, the c2h2storage capacity of fji-h33is 154 cm3/g, while the co2uptake is only 80 cm3/g.The ideal adsorbed solution theory (iast) selectivity of c2h2/co2(50:50) is calculated as high as 15.5 at 298 k.More importantly, the excellent practical separation performance was verified by breakthrough experiments.In addition, the calculation of adsorption sites and relevant energy by density functional theory (dft) provides a good explanation for the excellent separation performance and pore design strategy.

Journal: ACS applied materials & interfaces (2022)
Publication types: Journal Article
The predictive role of nursing students' individual characteristics and psychological resilience in psychological distress.

This study aims to determine the predictive role of nursing students' individual characteristics and psychological resilience in psychological distress.Design and methods this study is a descriptive cross-sectional study.The study sample included 652 nursing students.Binary logistic regression analysis was used for analysis.Findings it has been determined that 65.3% of nursing students have psychological distress.Having a chronic disease, being a woman, poor academic success, choosing the profession so as not to be unemployed, being single and low psychological resilience are factors that affect psychological distress.Practice implications it is recommended to screen nursing students for psychological distress to increase interventions that improve the psychological resilience of risky students.

Journal: Perspectives in psychiatric care (2021)
Publication types: Journal Article
Mass fractal dimension from 2D microscopy images via an aggregation model with variable compactness.

Microscopy-image analysis provides precious information on size and structure of colloidal aggregates and agglomerates.The structure of colloids is often characterized using the mass fractal dimensiondf$d_f$, which is different from the two-dimensional (2d) fractal dimensiondp$d_p$that can be computed from microscopy images.In this work, we propose to use a recent morphological aggregation model to find a relationship between 2d image fractal dimension and 3d mass fractal dimension of aggregates and agglomerates.Our case study is represented by scanning transmission electron microscopy images of boehmite colloidal suspensions.The behaviour of the computeddf$d_f$at different acid and base concentration shows a fair agreement with the results of small angle x-ray scattering and with the literature, enabling to use thedf$d_f$versusdp$d_p$relationship to study the impact of the composition of the colloidal suspension on the density of colloidal aggregates and agglomerates.

Journal: Journal of microscopy (2022)
Publication types: Journal Article
Utilization of intraoperative neuromonitoring during the Woodward procedure for treatment of Sprengel deformity.

Brachial plexus injury (bpi) leading to palsy of the upper extremities is the most serious complication of the woodward procedure for treatment of sprengel deformity.Intraoperative neuromonitoring (ionm) is widely used for detecting emerging spinal cord or peripheral nerve injury during spinal and shoulder surgery.However, to date, its utilization in pediatric patients with sprengel deformity is limited.Furthermore, it remains unclear whether ionm can help prevent bpi during surgery.The purpose of the current study was to assess the feasibility and effectiveness of ionm for early identification and prevention of nerve injury during the woodward procedure.Methods we retrospectively reviewed the records of patients who underwent the woodward procedure for sprengel deformity at our institution between january 2017 and january 2020.Ionm, including somatosensory evoked potentials (sep) and motor evoked potentials (meps), was performed in all patients.Detailed ionm data were collected and analyzed.Preoperative and postoperative cosmetic appearance (according to the cavendish classification), shoulder joint abduction function, and radiologic evaluation of the scapula were reviewed.Surgical complications were recorded.Results forty-six patients (19 girls, 27 boys) were included (mean age, 5.1 ± 2.1 years).Both sep and mep (amplitude of the abductor pollicis) were successfully performed (100%).Mep alerts occurred in 3 patients (6.5%).After scapula position adjustment, signals recovered in 2 patients and remained unchanged in 1 patient-this patient exhibited postoperative motor deficits that resolved completely by 4 months recovery.The sep amplitudes decreased in all 3 patients but did not reach the warning criteria.Forty patients were classified as grade iii and 6 as grade iv in the cavendish classification, whereas 35 patients were classified as grade ii and 11 as grade iii in the rigault scale.The preoperative cavendish grade was iii (iii, iv) and the postoperative cavendish grade was i (i, ii) (χ2= 88.098, p < .001).The preoperative rigault grade was ii (ii, iii) and the postoperative rigault grade was i (i, ii) (χ2= 62.133, p < .001).The mean arc of shoulder joint abduction improved from 99° ± 8° to 167° ± 7° (t = -45.871, p < .001) after surgery.Except for temporary motor deficits detected in 1 patient, no other postoperative complications were observed through the time of final follow-up.Conclusion ionm during the woodward procedure for sprengel deformity is feasible and effective in detecting intraoperative neurologic changes and may be effective in preventing bpi associated with surgery.

Journal: Journal of shoulder and elbow surgery (2022)
Publication types: Journal Article
Academic Perfectionism, Psychological Well-Being, and Suicidal Ideation in College Students.

High levels of perfectionism in college students can compromise their academic performance and psychological well-being.This study aims to analyze the implication of perfectionism in psychological well-being and suicidal ideation in the last year.A total of 1.287 students from different degrees reported their academic performance in the previous academic year and completed questionnaires on academic perfectionism, psychological well-being, and suicidal thoughts in the last year.In both men and women, academic perfectionism correlates positively with academic performance and negatively with the different dimensions of psychological well-being.Likewise, both the average grade in the previous year (β= 0.364) and the level of demand of the degree (β= -0.461) are mediating variables between perfectionism and psychological well-being.Furthermore, the interaction between perfectionism and academic performance is related positively to psychological well-being, but not to with suicidal ideation.So, the relation between suicidal ideation and perfectionism is positive (or = 1.075), but this is negative with academic performance (or = 0.900), although both variables show a mild predictive capacity.These findings suggest that the levels of perfectionism are associated differently with the mental health of students, since if perfectionism is effective (high academic performance), psychological well-being is high, although in our results, this interaction is not as important for suicidal thoughts.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article