syedzayyan/paper_mill_benchmark huggingface dataset:
Polyphenols from Arctium lappa L ameliorate doxorubicin-induced heart failure and improve gut microbiota composition in mice.

In this study, the ameliorative effect of purified polyphenols from arctium lappa l (alpp) on doxorubicin (dox)-induce heart failure was investigated.Results indicated that alpp pretreatment significantly reduced the activities of casein kinase and lactate dehydrogenase, lowered the levels of inflammatory indexes (tnf-α and no), and alleviated antioxidant stress in dox-induce mice, thus leading to a reduced heart failure syndrome.In addition, according to 16s high-throughput sequencing, the increased abundance of lactobacillaceae,muribaculaceae, and ruminococcaceae and the decreased abundance of proteobacteria,enterobacteriaee, and escherichia_shigella were observed in alpp treatment group.Alpp could significantly enhance the abundance of bacteria producing short chain fatty acids (scfas) and then promote the increase of scfas.Consequently, alpp might be a therapeutic alternative in the treatment of dox-induced heart failure.Practical applications: the effect of arctium lappa l (alpp) on doxorubicin (dox)-induced heart failure was investigated.It provided experimental basis for further studies on the biological activity of polyphenols from alpp.The results demonstrated that alpp could significantly ameliorate dox-induced heart failure and improve the gut microbiota composition.The obtained results could provide the potential application of alpp as an alternative therapy for heart failure in the functional food industry.

Journal: Journal of food biochemistry (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Müller-Lyer illusion: Cognitive style, attentional and temperamental determinants data.

While the cognitive predictors of visual illusions have been widely researched, thus far, the temperamental ones have not been studied.The dataset provides data on cognitive and temperamental determinants of the müller-lyer illusion recorded in a group of 170 participants aged 20-33.The cognitive predictors included: the field dependent-independent cognitive style and the efficacy of attention networks: alerting, orienting, and executive control.The dataset is related to the research findings in the paper 'cognitive and temperamental determinants of susceptibility to the müller-lyer illusion' published in personality and individual differences.

Journal: Data in brief (2021)
Publication types: Journal Article
Association between Receipt of Intrapartum Magnesium Sulfate and Postpartum Hemorrhage.

The aim of the study is to investigate the association between intrapartum administration of magnesium sulfate in women with hypertensive disorders of pregnancy and postpartum hemorrhage.study design this was a retrospective cohort study of women diagnosed with a hypertensive disorder of pregnancy who delivered singleton gestations >32 weeks at a single, large volume tertiary care center between january 2006 and february 2015.Women who received intrapartum magnesium sulfate for seizure prophylaxis were compared with women who did not receive intrapartum magnesium sulfate.The primary outcome was frequency of postpartum hemorrhage.Secondary outcomes included estimated blood loss, uterine atony, and transfusion of packed red blood cells.Bivariable analyses were used to compare the frequencies of each outcome.Multivariable logistic regression models examined the independent associations of magnesium sulfate with outcomes.results of 2,970 women who met inclusion criteria, 1,072 (36%) received intrapartum magnesium sulfate.Women who received magnesium sulfate were more likely to be nulliparous, publicly insured, of minority race or ethnicity, earlier gestational age at delivery, and undergo labor induction.The frequency of postpartum hemorrhage was significantly higher among women who received magnesium sulfate compared with those who did not (12.4 vs.9.3%,p= 0.008), which persisted after controlling for potential confounders.Of secondary outcomes, there was no difference in estimated blood loss between women who did and did not receive magnesium sulfate (250 m l [interquartile range 250-750] vs.250 m l [interquartile range 250-750],p= 0.446).However, compared with women who did not receive magnesium sulfate, women who received magnesium sulfate had a greater frequency of uterine atony (8.9 vs 4.9%,p< 0.001) and transfusion of packed red blood cells (2.0 vs.0.8%,p= 0.008).These differences persisted after controlling for potential confounders.conclusion intrapartum magnesium sulfate administration to women with hypertensive disorders of pregnancy is associated with increased odds of postpartum hemorrhage, uterine atony, and red blood cell transfusion.

Journal: AJP reports (2021)
Publication types: Journal Article
Association of Estrogen-Related Polygenetic Risk Scores with Breast Cancer and Interactions with Alcohol Intake, Early Menarche, and Nulligravida.

S early menstruation, late menopause, no pregnancy, and genetic factors are known risk factors of the disease, but their effects may differ in asian and caucasian women.The purpose of this study was to identify genetic variants of genes related to estrogen signaling in a large city hospital-based cohort and to determine their interactions with lifestyles.Methods this is a case-control study.Three hundred ninety participants diagnosed with breast cancer were compared with 36,290 controls(no cancer)to explore the genetic variants to influence breast cancer risk.Based on gwas results, the selected genetic variants were subjected to their interactions by generalized multifactor dimensionality reduction (gmdr) analysis.Results early menstruation(or=1.55), early menopause (or=1.70), and no experience of pregnancy(or=2.86) had a positive association with breast cancer risk(p<0.05).The selected polygenetic risk score(prs) models included four snps and seven snps: the four-snp prs model included cdh13_rs12600325, smyd3_rs3753686, fgf12_rs2134635, and esrrb_rs10873289, and in the seven-snp prs model, esr1_ rs2046210, estrogen-related receptor gamma(esrrg)_rs17043393, and egfr_ rs6958497 were added into the four-snp prs model.Early menstruation, early menopause, and no pregnancy experience interacted with four-snp prs.For the participants who had early menstruation and early menopause, high-prs had an association with a much higher breast cancer risk than the low-prs in the four-snp model.However, metabolic parameters, nutrient intakes, and different dietary patterns did not interact with prs for breast cancer risk.However, alcohol intake interacted with prs for breast cancer risk (or=2.33 and 8.07 for mild and moderate alcohol consumption, respectively; p=0.0004).Conclusion consideration of age at menarche and menopause, pregnancy experience, and alcohol intake may be required to reduce breast cancer risk in women with a high-prs of genes related to the estrogen signaling pathway.

Journal: Asian Pacific journal of cancer prevention : APJCP (2022)
Publication types: Journal Article
Internet-based peer support interventions for people living with HIV: A scoping review.

Peer support interventions for people living with hiv and aids (plwha) are effective, but their associated time and material costs for the recipient and the health system make them reachable for only a small proportion of plwha.Internet-based interventions are an effective alternative for delivering psychosocial interventions for plwha as they are more accessible.Currently, no reviews are focusing on internet-based interventions with peer support components.This scoping review aims to map the existing literature on psychosocial interventions for plwha based on peer support and delivered through the internet.We conducted a systematic scoping review of academic literature following methodological guidelines for scoping reviews, and 28 articles met our criteria.We summarized the main characteristics of the digital peer support interventions for plwha and how they implemented peer support in a virtual environment.Overall the reported outcomes appeared promising, but more robust evidence is needed.

Journal: PloS one (2022)
Publication types: Journal Article;Systematic Review;Research Support, Non-U.S. Gov't
Rates in Bronchiolitis Hospitalization, Intensive Care Unit Use, Mortality, and Costs From 2004 to 2018.

Importance over the last 2 decades, bronchiolitis guidelines and improvement efforts focused on supportive care and reducing unnecessary tests, treatments, and hospitalization.There have been limited population-based studies examining hospitalization outcomes over time.Objective to describe rates and trends in bronchiolitis hospitalization, intensive care unit (icu) use, mortality, and costs.Design, setting, and participants this cohort study used population-based health administrative data from april 1, 2004, to march 31, 2018, to identify bronchiolitis encounters using hospital discharge diagnosis codes in ontario, canada.Children younger than 2 years with and without bronchiolitis hospitalization were included.Data were analyzed from january 2020 to july 2021.Main outcomes and measures bronchiolitis hospitalization per 1000 person-years, icu use per 1000 hospitalizations, mortality per 100 000 person-years, and costs per 1000 person-years adjusted to 2018 canadian dollars and reported in 2018 us dollars.Results among 2 336 446 included children, 1 199 173 (51.3%) were male.During the study period, 43 993 children (1.9%) younger than 2 years had 48 058 bronchiolitis hospitalizations at 141 hospitals.Bronchiolitis accounted for 48 058 of 360 920 all-cause hospitalizations (13.3%) and 215 654 of 2 566 348 all-cause hospital days (8.4%) in children younger than 2 years.Bronchiolitis hospitalization was stable over time, at 14.0 (95% ci, 13.6-14.4) hospitalizations per 1000 person-years in 2004-2005 and 12.7 (95% ci, 12.2-13.1) hospitalizations per 1000 person-years in 2017-2018 (annual percent change [apc], 0%; 95% ci, -1.6 to 1.6; p = .97).Icu admission increased significantly from 38.1 (95% ci, 32.2-44.8) per 1000 hospitalizations in 2004-2005 to 87.8 (95% ci, 78.3-98.0) per 1000 hospitalizations in 2017-2018 (apc, 7.2%; 95% ci, 5.4-8.9; p < .001).Over the study period, bronchiolitis mortality was 2.8 (95% ci, 2.3-3.4) per 100 000 person-years and remained stable (apc, 1.1%; 95% ci, -8.4 to 11.7; p = .85).Hospitalization costs per 1000 person-years increased from $49 640 (95% ci, $49 617-$49 663) in 2004-2005 to $58 632 (95% ci, $58 608-$58 657) in 2017-2018 (apc, 3.0%; 95% ci, 1.3-4.8; p = .002).Conclusions and relevance from 2004 to 2018, bronchiolitis hospitalization and mortality rates remained stable; however, icu use and costs increased substantially.This represents a major increase in high-intensity hospital care and costs for one of the most common and cumulatively expensive conditions in pediatric hospital care.

Journal: JAMA pediatrics (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Electroacupuncture improves repeated social defeat stress-elicited social avoidance and anxiety-like behaviors by reducing Lipocalin-2 in the hippocampus.

Post-traumatic stress disorder (ptsd) is a trauma-related disorder that is associated with pro-inflammatory activation and neurobiological impairments in the brain and leads to a series of affective-like behaviors.Electroacupuncture (ea) has been proposed as a clinically useful therapy for several brain diseases.However, the potential role of ea treatment in ptsd and its molecular and cellular mechanisms has rarely been investigated.Methods we used an established preclinical social defeat stress mouse model to study whether ea treatment modulates ptsd-like symptoms and understand its underlying mechanisms.To this end, male c57bl/6 mice were subjected to repeated social defeat stress (rsds) for 6 consecutive days to induce symptoms of ptsd and treated with ea at baihui (gv 20) and dazhui (gv 14) acupoints.Results the stimulation of ea, but not needle insertion at baihui (gv 20) and dazhui (gv 14) acupoints effectively improved ptsd-like behaviors such as, social avoidance and anxiety-like behaviors.However, ea stimulation at the bilateral tianzong (si11) acupoints did not affect the ptsd-like behaviors obtained by rsds.Ea stimulation also markedly inhibited astrocyte activation in both the dorsal and ventral hippocampi of rsds-treated mice.Using next-generation sequencing analysis, our results showed that ea stimulation attenuated rsds-enhanced lipocalin 2 expression in the hippocampus.Importantly, using double-staining immunofluorescence, we observed that the increased lipocalin 2 expression in astrocytes by rsds was also reduced by ea stimulation.In addition, intracerebroventricular injection of mouse recombinant lipocalin 2 protein in the lateral ventricles provoked social avoidance, anxiety-like behaviors, and the activation of astrocytes in the hippocampus.Interestingly, the overexpression of lipocalin 2 in the brain also altered the expression of stress-related genes, including monoamine oxidase a, monoamine oxidase b, mineralocorticoid receptor, and glucocorticoid receptor in the hippocampus.Conclusions this study suggests that the treatment of ea at baihui (gv 20) and dazhui (gv 14) acupoints improves rsds-induced social avoidance, anxiety-like behaviors, astrocyte activation, and lipocalin 2 expression.Furthermore, our findings also indicate that lipocalin 2 expression in the brain may be an important biomarker for the development of ptsd-related symptoms.

Journal: Molecular brain (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Delta-aminolevulinate dehydratase enzyme activity and the oxidative profile of pregnant women being treated for acute toxoplasmosis.

The aim of this study was to investigate the clinical and oxidative profile, including the activity of the enzyme delta-aminolevulinate dehydratase (δ-ala-d), in women who acquired toxoplasmosis during pregnancy and used the triple regimen (sulfadiazine + pyrimethamine + folinic acid [spfa]) as treatment.These parameters have not been evaluated in pregnant women with toxoplasmosis who used the triple regimen.A total of 53 pregnant women were recruited and divided into two groups: control (c; n = 27) and acute toxoplasmosis (at; n = 26).Clinical data and blood samples were obtained from all patients.The clinical profile was analyzed by checking parameters such as body mass index, blood pressure, and complete blood count.Oxidative stress was evaluated by quantifying protein (p-sh) and non-protein (np-sh) thiol groups, vitamin c, plasma iron reduction capacity (frap), δ-ala-d enzyme activity, reactive substances to thiobarbituric acid (tbars), and nitric oxide (no).Changes in hematological parameters (increased red cell distribution width and decreased hemoglobin and mean corpuscular hemoglobin concentration), increased antioxidant system (p-sh, np-sh, frap, δ-ala-d enzyme activity), as well as damage markers (tbars and no), were significantly elevated in pregnant women with toxoplasmosis, compared to those in the control group.Pregnant women treated for this acute infection showed increased damage markers, as well as a significant increase in the antioxidant system, including the activity of the δ-ala-d enzyme.Given this evidence, it is suggested that these changes occur as a form of compensation, with a possible contribution from drug therapy.

Journal: Microbial pathogenesis (2022)
Publication types: Journal Article
Identification of the Temperature Dependence of the Thermal Expansion Coefficient of Polymers.

In this paper, we proposed an approach to study the strain response of polymer film samples under various temperature effects and note their corresponding effects.The advantages of the developed approach are determined by the fact that thin films of material are used as samples where it is possible to generate a sufficiently uniform temperature field in a wide range of temperature change rates.A dynamic mechanical analyzer was used for the experimental implementation of the above approach for two uv-curable polymers and one type of epoxy resin.Experimental results have shown that the thermal expansion coefficients for these polymers depend significantly not only on the temperature but also on its change rate.The strain response of the polymer to heating and cooling, with the same absolute values of the rate of temperature change, differs significantly, and this dissimilarity becomes stronger with its increasing.The results of thermomechanical experiments for massive samples on traditional dilatometer are shown to compare with the results for film samples.The discovered dependences of the temperature expansion coefficient on the temperature and its change rate can be used for mathematical modeling of thermomechanical processes arising during the operation of products made of polymers.

Journal: Polymers (2021)
Publication types: Journal Article
Central vein sign: A diagnostic biomarker in multiple sclerosis (CAVS-MS) study protocol for a prospective multicenter trial.

The specificity and implementation of current mri-based diagnostic criteria for multiple sclerosis (ms) are imperfect.Approximately 1 in 5 of individuals diagnosed with ms are eventually determined not to have the disease, with overreliance on mri findings a major cause of ms misdiagnosis.The central vein sign (cvs), a proposed mri biomarker for ms lesions, has been extensively studied in numerous cross sectional studies and may increase diagnostic specificity for ms.Cvs has desirable analytical, measurement, and scalability properties."central vein sign: a diagnostic biomarker in multiple sclerosis (cavs-ms)" is an nih-supported, 2-year, prospective, international, multicenter study conducted by the north american imaging in ms cooperative (naims) to evaluate cvs as a diagnostic biomarker for immediate translation into clinical care.Study objectives include determining the concordance of cvs and mc donald criteria to diagnose ms, the sensitivity of cvs to detect ms in those with typical presentations, and the specificity of cvs among those with atypical presentations.The study will recruit a total of 400 participants (200 with typical and 200 with atypical presentations) across 11 sites.T2*-weighted, high-isotropic-resolution, segmented echo-planar mri will be acquired at baseline and 24 months on 3-tesla scanners, and flair* images (combination of flair and t2*) will be generated for evaluating cvs.Data will be processed on a cloud-based platform that contains clinical and cvs rating modules.Imaging quality control will be conducted by automated methods and neuroradiologist review.Cvs will be determined by select6* and select3* lesion methods following published criteria at each site and by central readers, including neurologists and neuroradiologists.Automated cvs detection and algorithms for incorporation of cvs into mc donald criteria will be tested.Diagnosis will be adjudicated by three neurologists who served on the 2017 international panel on the diagnosis of ms.The cavs-ms study aims to definitively establish cvs as a diagnostic biomarker that can be applied broadly to individuals presenting for evaluation of the diagnosis of ms.

Journal: NeuroImage. Clinical (2021)
Publication types: Clinical Trial Protocol;Journal Article;Research Support, N.I.H., Extramural;Research Support, N.I.H., Intramural
Development of a CRISPR interference system for selective gene knockdown in Acidithiobacillus ferrooxidans.

Acidithiobacillus ferrooxidans is an iron-oxidizing chemolithotroph used for bioleaching of precious metals and is also regarded as a potential host for bioelectrochemical production of value-added chemicals.Despite its industrial utility, however, it is difficult to genetically engineer a.Ferrooxidans due to low transformation and recombination efficiencies.Here, we developed a clustered regularly interspaced short palindromic repeats interference (crispri) system that can selectively repress the expression of a target gene in a.Ferrooxidans.The mutated gene encoding a nuclease-deactivated cas9 protein was cloned into the broad-host-range plasmid p bbr1-mcs2, and the applicability of the crispri system was examined using the nitrogenase nif h gene as a knockdown target.Introduction of the crispri plasmid into a.Ferrooxidans resulted in decreased nif h transcription and retarded cell growth in the absence of nitrogen sources, demonstrating that the crispri system altered the phenotype of this bacterium via selective gene knockdown.We suggest that the crispri system developed in this study provides an efficient technique for constructing a.Ferrooxidans knockdown mutants that are useful for the genetic dissection of this bacterium.

Journal: Journal of bioscience and bioengineering (2022)
Publication types: Journal Article
Human amniotic membrane intra-articular injection prevents cartilage damage in an osteoarthritis model.

Osteoarthritis (oa) is a degenerative joint disease that affects the soft tissues and bones of involved articulations as a result of deregulation between synthesis and extracellular matrix degradation in articular cartilage.The present study evaluated the effect of intra-articular injection of human amniotic membrane (am) as a treatment in an oa animal model in the knee.Chemical oa was developed in the knees of new zealand rabbits.Once oa was established, the right knees only were treated with an intra-articular injection of human am, with the left knees considered as a negative control group.The evaluation was performed at 3 and 6 weeks post-treatment.At 3 weeks post-injection, the cartilage exhibited fibrillation, erosion, cracks and cell clusters in the negative control group, but not in the treated group (p=0.028).At 6 weeks post-injection, the left knees exhibited hypertrophy, cracks, cell clusters, decreased matrix staining and structure loss.However, the right knees exhibited cell clusters without evidence of disruption in cartilage integrity (p=0.015).These results suggested that the intra-articular injection of human am delays histological changes of cartilage in oa.

Journal: Experimental and therapeutic medicine (2019)
Publication types: Journal Article
Shining a light on autophagy in neurodegenerative diseases.

Small-molecule modulators of autophagy have been widely investigated as potential therapies for neurodegenerative diseases.In a recent issue of jbc, safren et al.Described a novel assay that uses a photoconvertible fusion protein to identify compounds that alter autophagic flux.Autophagy inducers identified using this assay were found to either alleviate or exacerbate neurotoxicity in different cellular models of amyotrophic lateral sclerosis, challenging the notion that autophagy stimulation can be used as a one-size-fits-all therapy for neurodegenerative disease.

Journal: The Journal of biological chemistry (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.;Comment
MicroRNA-30c-2-3p targets STRIP2 to suppress malignant progression of gastric cancer cells.

Micro rna plays a crucial part in genesis and development of gastric cancer (gc).We uncovered that micro rna-30c-2-3p was down-regulated in gc tissue and cell lines.Suppression of micro rna-30c-2-3p promoted progression of gc cells in vitro.Strip2 was confirmed as a target for micro rna-30c-2-3p.Micro rna-30c-2-3p overexpression remarkably suppressed cell malignant behaviours, while reintroduction of strip2 partially restored the anticancer effect of micro rna-30c-2-3p.Taken together, these findings suggested that micro rna-30c-2-3p acted as a candidate tumour suppressor in gc by directly targeting strip2.Therefore, micro rna-30c-2-3p can be used as a towardly gc therapeutic target.

Journal: Journal of biochemistry (2022)
Publication types: Journal Article