syedzayyan/paper_mill_benchmark huggingface dataset:
Multipoint Distribution Vehicle Routing Optimization Problem considering Random Demand and Changing Load

In the distribution scenario, the using cost of vehicles is closely related to energy consumption, and the energy consumption rate of a vehicle is closely related to the size of its load.The traditional vehicle routing optimization model takes the shortest distance as the optimization goal when the customer demand is determined, while the influence of the random demand and the changing load on the energy consumption and cost of vehicles in the process of distribution is ignored.Therefore, in this paper, load varying vehicle routing problem with stochastic demands (lvgvrpsd) model is proposed with the goal of minimizing transportation energy consumption and considering the load variability and the randomness of customer demand.K-means clustering algorithm is combined with ant colony optimization (aco) to solve the problem, and the constraint of risk probability is introduced to describe the vehicle overload problem.Examples in the standard vehicle routing problem test data set are provided and analyzed.Lvgvrpsd is also compared with the traditional capacitated vehicle routing problem (cvrp) model.The case study results show that the vehicle energy consumption can be reduced by 2% in the model that considers changing load compared to the model that does not consider changing load.The results illustrate that the method of path optimization is more advantageous and reasonable in the pursuit of reducing energy consumption, when the changing load and the random demand of customer are considered.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
MRI View of Rehabilitation Methods to Relieve Anterior Cruciate Ligament Injury in Dancers

In order to solve the problem of the difference in the diagnostic effect of different sequences of magnetic resonance imaging (mri) examinations for anterior and posterior cruciate ligament injuries, the author proposes an mri rehabilitation method to relieve anterior cruciate ligament injury in dancers.This method retrospectively analyzed the clinical data of 60 patients with knee anterior and posterior cruciate ligament injuries in our hospital, and all patients were diagnosed with knee anterior and posterior cruciate ligament injuries.All patients underwent mri 3d sequence and 2d sequence examination successively to compare anatomical measurements.This study aimed at comparing the measurements of the posterior cruciate ligament (pcl) and anterior cruciate ligament (acl) between the two examination sequences; comparing the diagnosis; comparing the grading and judgment of the anterior and posterior cruciate ligament injuries of the knee joint between the two inspection sequences; and comparing the diagnostic coincidence rates of the two examination sequences in the complete tear of the anterior and posterior cruciate ligaments of the knee.Experimental results show that, in terms of pcl and acl, the angle, thickness, and length of two-dimensional mri examination were significantly different from those of mri examination and anatomical measurement ( p &lt; 0.05 ); for pcl and acl, the angle, thickness, and length of 3d mri were not significantly different from anatomical measurements ( p &gt; 0.05 ).The diagnostic accuracy of 2d mri was 83.33%, which was lower than 95.00% of 3d mri ( p &lt; 0.05 ).There was no significant difference in the grading of anterior and posterior cruciate ligament injuries between the two examination sequences ( p &gt; 0.05 ).The diagnostic coincidence rates of 3d mri and 2d mri for complete tear of the anterior and posterior cruciate ligaments were 95.55% and 80.00%, respectively ( p &lt; 0.05 ).In conclusion, three-dimensional mri examination can obtain higher diagnostic value for patients with knee joint anterior and posterior cruciate ligament injury.

Journal: Scanning (2022)
Publication types: Research Article;
MRI and DC/TMD Methods Analyze the Diagnostic Accuracy of the Change in Articular Disc of Temporomandibular Joint

Object.The diagnostic superiority of functional magnetic resonance imaging (f mri) over temporomandibular joint disc (tmj) changes was investigated by comparing the diagnostic results of magnetic resonance imaging (mri) and dc/tm.Methods.Dc/tmd clinical questionnaire diagnosis was conducted for 30 patients with temporomandibular disorder (tmd) and 11 asymptomatic volunteers who were admitted to the department of oral medicine of the first hospital affiliated with jinan university from june 2020 to june 2021.At the same time, mri scanned the opening and closed positions to obtain the image information of the articular disc and compared the diagnostic difference between mri and dc/tmd to the position of the articular disc through statistical analysis.Results.The probability of dc/tmd’s diagnosis of reusable/nonreusable anterior disc displacement (add) was 80.1% and 62.7%, respectively.Conclusion.Dc/tmd’s diagnosis of abnormal articular disc position is less accurate than mri testing.Therefore, the diagnosis of these two diseases for dc/tmd examination is of little significance, and mri examination is required at the same time.It can improve diagnosis specificity and sensitivity, reduce missed diagnosis and misdiagnosis rates to ensure that true positive patients can be detected in time, and establish a basis for clinical diagnosis and treatment.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Monitoring and Analysis Solid Formulation Dissolution Phenomenon with Image Recognition Technologies

The dissolution test has become the most important quality index in the research and development of solid formulation, especially the evaluation of drug bioequivalence.However, it had low operability, was tedious, and was always overlooked.The previously related studies required a fixed tablet and analysed the recorded video by disso guaro pro and microsoft painttm.Therefore, we have developed a novel image recognition system to automatically track the moving tablet and analyse the volume change at the same time.Image recognition technology is often used to monitor the dissolution process.The camera system with visible light and infrared camera functions was placed on the dissolution tester.The system collects the plate image for binary processing and then records and calculates its pixel area, which can automatically record the volume change of the tablet in the dissolution test, no matter disintegration or corrosion.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Molecular Mechanism of Gas Anesthetics on the Invasion, Metastasis, and Chemosensitivity of Osteosarcoma Cells

Osteosarcoma is one of the most prominent bone cancers which has a predominant occurrence in children and adolescents.This study is focused on determining the effects of treatment of gas anesthetics on invasion, metastasis, and chemosensitivity in the progression of osteosarcoma cells.Material and methods.The biological effects of the common gas anesthetics—desflurane, isoflurane, and sevoflurane—on osteosarcoma cells were studied and compared.The biological assays were performed for analysis of cell migration and proliferation.Results.Isoflurane and sevoflurane have shown significant inhibition in the osteosarcoma cells at clinically relevant concentrations.Desflurane has shown less potent action on cell migration and inhibition.All three gas anesthetics have shown inhibition in cell proliferation.The effective antiproliferative action was at a clinically significant dose.At low millimolar concentrations, cell apoptosis was moderately affected.Drug combination analysis with chemotherapeutic drugs showed relevant inhibition in cell migration.All three agents showed significant augmentation of chemotherapeutic drugs in suppression and inhibition of inducing apoptosis.The antimigration action is likely to affect the pi3k/akt pathway and igf-1.Conclusion.The study demonstrates the proposed mechanisms of gas anesthetics and their differential effects on osteosarcoma cells and their survival, migration, growth, and chemosensitivity.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
Mining of Potential Biomarkers and Pathway in Valvular Atrial Fibrillation (VAF) via Systematic Screening of Gene Coexpression Network

We apply the bioinformatics method to excavate the potential genes and therapeutic targets associated with valvular atrial fibrillation (vaf).Methods.The downloaded gene expression files from the gene expression omnibus (geo) included patients with primary severe mitral regurgitation complicated with sinus or atrial fibrillation rhythm.Subsequently, the differential gene expression in left and right atrium was analyzed by r software.Additionally, weighted correlation network analysis (wgcna), principal component analysis (pca), and linear model for microarray data (limma) algorithm were used to determine hub genes.Then, metascape database, david database, and string database were used to annotate and visualize the gene ontology (go) analysis, kegg pathway enrichment analysis, and ppi network analysis of differentially expressed genes (degs).Finally, the tfs and mi rnas were predicted by using online tools, such as pastaa and mi rdb.Results.20,484 differentially expressed genes related to atrial fibrillation were obtained through the analysis of left and right atrial tissue samples of gse115574 gene chip, and 1,009 were with statistical significance, including 45 upregulated genes and 964 downregulated genes.And the hub genes implicated in af of npc2, odc1, snap29, laptm5, st8sia5, and fcgr3b were screened.Finally, the main regulators of targeted candidate biomarkers and micro rnas, eif5a2, hif1a, zic2, elf1, and stat2, were found in this study.Conclusion.These hub genes, npc2, odc1, snap29, laptm5, st8sia5, and fcgr3b, are important for the development of vaf, and their enrichment pathways and tfs elucidate the involved molecular mechanisms and assist in the validation of drug targets.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Microencapsulation of Fe2+ in Spray-Dried Lactose for Improved Bioavailability

The development of spray drying technology has been widely used for drying and preservation of food products.Though infant milk powder iron fortification is necessary for infants and children, iron fortification is accompanied by some limitations that reduce its quality and oxidation of fe2+ into fe3+, causing sensory problems and even a decrease in iron absorption, which does not meet the normal requirements of infant and child body development.To overcome this adverse effect and to improve the bioavailability of iron, a spray drying method was used to simulate the milk powder production process by codrying a mixture of ascorbic acid and ferrous sulfate, where ascorbic acid was uniformly coated on the outer layer of ferrous sulfate.It was demonstrated that ascorbic acid had a very obvious inhibitory effect on the oxidation of ferrous iron and could maintain the stability of ferrous iron in solid and solution for a long time, thus improving the bioavailability of iron.

Journal: Bioinorganic Chemistry and Applications (2021)
Publication types: Research Article;
Microarray and Bioinformatics Analysis of Differential Gene and lncRNA Expression during Erythropoietin Treatment of Acute Spinal Cord Injury in Rats

We performed a genome-wide analysis of long noncoding rna (lnc rna) expression to identify novel targets for the further study of recombinant human erythropoietin (rh epo) treatment of acute spinal cord injury (sci) in rats.Methods.Nine rats were randomly divided into 3 groups.No operation was performed in group 1.In groups 2 and 3, a laminectomy was performed at the 10th thoracic vertebra, and a contusion injury was induced by extradural application of an aneurysm clip.Group 1 rats did not receive any treatment, group 2 rats received a single intraperitoneal injection of normal saline, and group 3 rats received rh epo.Three days after injury, spinal cord tissues were collected for rna-seq, microarray, differentially expressed genes (degs), gene ontology (go) function enrichment, kyoto encyclopedia of genes and genomes (kegg) pathway enrichment, and protein-protein interaction (ppi) analyses.Results.Compared with group 1, 4,446 genes were found to be differentially expressed in group 2.Furthermore, 99 lnc rnas were found to be changed in the injury group.The data indicate that 2,471 m rnas were upregulated, and 1,975 m rnas were downregulated in group 2 as compared with group 1.In addition, 45 of the lnc rnas were upregulated, and the other 44 lnc rnas were downregulated.The top 5 upregulated and top 5 downregulated lnc rnas that were different between group 2 and group 1 are shown.The top 5 downregulated and the top 5 upregulated lnc rnas that were different between group 3 and group 2 are shown.Conclusion.Rh epo treatment alters the expression profiles of the differentially expressed lnc rnas and genes beneficial to the development of new treatments.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Review Article;
Meta-Analysis of the Effectiveness and Safety of Glucocorticoid for the Treatment of IgA Kidney Disease

To explore the effect of glucocorticoid on immune globulin a (ig a) nephropathy by meta-analysis.Method.Search the data and literature libraries of science direct, ebsco, wiley, pub med, cbmdisc, and cnki and collect the literature on the treatment of ig a nephropathy with glucocorticoids as randomized controlled trials published at home and abroad from 1995 to 2021.The standardized mean difference (smd) and 95% confidence interval (ci) were calculated by fixed-effects model.Rev man 5.0 software was used for meta-analysis of the subgroups of overall curative effect, different degree of proteinuria, different course of treatment, different creatinine level, and combined acei.Result.1 the overall efficacy of glucocorticoid in the treatment of ig a nephropathy was better than that in the control group ( p = 0.00001).2 the efficacy of glucocorticoid treatment in patients with ig a nephropathy with proteinuria greater than 1.50 g/d and less than 1.50 g/d was better than that in the control group ( p &lt; 0.01).3 for ig a nephropathy patients with serum creatinine less than 1.50 mg/dl, the curative effect of glucocorticoid treatment was better than that of the control group ( p &lt; 0.01).4 the effects of short-term treatment (&lt;1 year) and long-term treatment (≥1 year) with glucocorticoid were better than those in the control group ( p &lt; 0.01).5 the effect of hormone combined with acei drugs on ig a nephropathy was more significant ( p &lt; 0.01).Conclusion.The overall efficacy of glucocorticoid in the treatment of ig a nephropathy is accurate.Hormone treatment is effective for different degrees of ig a nephropathy.Considering that there is no significant effect on the efficacy of different courses of treatment, it is suggested that the course of hormone treatment can be appropriately shortened.Hormone combined with angiotensin-converting enzyme inhibitors (acei) can reduce proteinuria more effectively than acei drugs alone.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Meta-Analysis;
Meta-Analysis of the Association Study between Allergic Rhinitis and HLA-II Gene (DQB1) in Northern China

To explore the association between allergic rhinitis and hla-ii gene (dqb1) in the chinese population.Methods.The literature studies related to allergic rhinitis and hla-ii gene (dqb1) in the chinese population were searched, and those that did not meet the requirements were excluded.The consistency was checked by using rev man 4.1 software.Results.The hla-ii gene (dqb1) may be a risk gene for patients with allergic rhinitis in northern china ( p &lt; 0.01 ).Conclusion.Allergic rhinitis in china was associated with the hla-ii gene (dqb1).

Journal: Journal of Healthcare Engineering (2021)
Publication types: Meta-Analysis;
Medical Image Recognition Technology in the Effect of Substituting Soybean Meal for Fish Meal on the Diversity of Intestinal Microflora in Channa argus

To study the application of medical image recognition technology based on backpropagation neural network (bpnn) in the effect of soybean meal replacing fish meal on intestinal microbial diversity of channa argus and to evaluate the application value of this intelligent algorithm, channa argus was fed with different contents of soybean meal instead of fish meal.Methods.After intestinal samples were collected and bacteria were isolated, microscopic imaging was performed, and the images were classified and identified.Bpnn was constructed to perform denoising, smoothing, and segmentation.Results.After bpnn processing, the bacteria were completely separated from the original image background, and the bacteria was in the closed state, which was beneficial to feature extraction and species recognition.If there were 2 hidden layer nodes, the segmentation accuracy of bacterial microscopic images was the highest, up to 97.3%.With the replacement ratio of fish meal increased, the species of intestinal microbiome gradually enriched, and the relative abundance of intestinal microbiome was higher after fish meal was completely replaced by soybean meal (replacement).The intestinal microbial enzyme activities were affected by different fish meal and soybean meal contents in the diet.The glutamate transaminase and adenosine deaminase activities were increased after the replacement and were higher than those before the replacement, with statistically significant differences ( p &lt; 0.05 ).Conclusion.Replacement of fish meal with soybean meal has a significant effect on the intestinal flora diversity of channa argus, and there is a close relationship between them.The image recognition technology based on bpnn has high recognition rate and segmentation accuracy for microbiological microscopic images.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Mechanisms of Banxia Xiexin Decoction Underlying Chronic Atrophic Gastritis via Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations

Chronic atrophic gastritis (cag) is a common chronically digestive disease which is notoriously characterized by atrophy of the epithelium and glands of the gastric mucosa, reduced number, thinning of the gastric mucosa, thickening of the mucosal base, or pyloric glandular hyperplasia and intestinal glandular hyperplasia, or with atypical hyperplasia.Banxia xiexin decoction (bxd) has been applied for two thousand years and is considered an effective therapy for functional dyspepsia, gastroesophageal reflux disease and colon cancer.In this current study, to probe into the underlying mechanism of bxd on cag, network pharmacology was conducted to collect druggable ingredients and predicted targets of bxd and the cag-associated targets were harvested to take intersection with druggable ingredients from bxd predicted targets to obtain potential critical action targets.Subsequently, go enrichment analysis and kyoto encyclopedia of genes and genomes pathway enrichment analysis were conducted to elucidate the underlying mechanisms and roles from the perspective of overall pathways and cellular functions.Eventually, molecular docking integrated with molecular dynamics simulations was conducted to further investigate the mechanism of action of bxd active ingredients on cag from drug molecule-target interactions and to provide a theoretical basis for bxd drug development.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Mechanical Analysis and Clinical Application of Butterfly-Shaped Patellar Claw

Memory alloy patella claws for treating patella fractures have been used for more than 30 years with many desirable features including fast healing, quick recovery, and avoidance of top abrasion of kirschner wires and other complications.However, there are many models and it is difficult to choose the accurate claw for the patient.In this study, a finite element model of the butterfly-shaped patellar claw made of shape memory alloy was established, its mechanical structure was analyzed, and its clinical application was monitored.We used solidworks simulation software for modeling and mainly analyzed the force of the compression ring of the butterfly-shaped patellar claw.Clinically, we chose a closed fresh patella fracture case.After finite element analysis, the maximum stress that the compression ring of the butterfly-shaped patellar claw can withstand is 568.1 mpa.In this range, it always has elastic deformation resistance.The butterfly-shaped patella claw is fixed on the patella and will not break when subjected to a maximum force of 150 n on the encircling arm, and at the same time, there will be no pressure failure due to plastic deformation.A total of 27 cases were clinically used for the assessment of the clinical efficacy of the newly designed butterfly-shaped patella claws.The average follow-up time was 15.5 months, and the average fracture healing time was 8-12 weeks.All patients can get out of bed with crutches within 2 to 3 days after surgery.Among them, there were 15 cases with excellent functional ratings, 10 cases with good ratings, 2 cases with acceptable ratings, and no cases with poor ratings.The designed butterfly-shaped patella claws can provide an effective method for the treatment of patella fractures.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
MDH1 and MDH2 Promote Cell Viability of Primary AT2 Cells by Increasing Glucose Uptake

Acute lung injury (ali) is a clinical disease with high morbidity and mortality, with limited treatment means.For primary alveolar epithelial type ii (at2) cells, glycolysis is an essential bioenergetic process.However, the significance of at2 cell glycolysis in sepsis ali remains unknown.Methods and results.In the current study, based on microarray analysis, real-time quantitative pcr, and western blotting, we found that the hsa00020: citrate cycle pathway was inactivated, specifically its downstream gene: malate dehydrogenase 1 (mdh1) and mdh2 in ali.In this context, lipopolysaccharides (lps) were used to construct the septic-ali mouse model and the biological function of mdh1 and mdh2 in primary alveolar epithelial type ii (at2) cells was explored.Through cck-8, ed u, transwell, and apoptosis assays, we found that mdh1 and mdh2 promoted the cell vitality of at2 cells, which relied on mdh1 and mdh2 to promote the glucose intake of at2 cells.Conclusion.Overall, these findings suggest that targeting mdh1/mdh2-mediated at2 cell glycolysis may be a potential strategy for ali patients.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Review Article;