syedzayyan/paper_mill_benchmark huggingface dataset:
Enhanced Corrosion Resistance of Layered Double Hydroxide Films on Mg Alloy: The Key Role of Cationic Surfactant.

In this study, dense anticorrosion magnesium-aluminum layered double hydroxide (mg al-ldh) films were prepared for the first time by introducing a cationic surfactant tetradecyltrimethyl ammonium bromide (ttab) in the process of in situ hydrothermal synthesis of mg-al ldh films on an az31 magnesium alloy.Results of xrd, ftir, and sem confirmed that ttab forms the mg al-ldh-ttab, although ttab cannot enter into ldh layers, and mg al-ldh-ttab powders are much smaller and more homogenous than mg al-co32--ldh powders.Results of sem, eds, mapping, and xps confirmed that ttab forms the mg al-ldh-ttab films and endows ldh films with denser structure, which provides films with better shielding efficiency.Results of potentiodynamic polarization curves (pdp) and electrochemical impedance spectroscopy (eis) confirmed that mg al-ldh-ttabx gfilms have better corrosion resistance than an mg al-co32--ldh film.The corrosion current density (icorr) of the mg al-ldh-ttab0.35 gfilm in 3.5 wt.% na cl solution was reduced to 1.09 × 10-8a.cm-2and the |z|f = 0.05 hzvalue was increased to 4.48 × 105ω·cm2.Moreover, the increasing concentration of ttab in mg al-ldh-ttabx g(x = 0.025, 0.05, 0.1, 0.2 and 0.35) provided denser outer layer ldh films and thereby increased the corrosion resistance of the az31 mg alloy.Additionally, the |z|f = 0.05 hzvalues of the mg al-ldh-ttab0.35 gfilm still remained at 105ω·cm2after being immersed in 3.5 wt.% na cl solution for 168 h, implying the good long-term corrosion resistance of mg al-ldh-ttabx gfilms.Therefore, introducing cationic surfactant in the process of in situ hydrothermal synthesis can be seen as a novel approach to creating efficient anticorrosion ldh films for mg alloys.

Journal: Materials (Basel, Switzerland) (2022)
Publication types: Journal Article
Geometrical Dependence on the Onset of Surface Plasmon Polaritons in THz Grid Metasurfaces.

The transmission response of metallo-dielectric grid metasurfaces is experimentally investigated through terahertz time domain spectroscopy and the corresponding effective dielectric function is retrieved.Using a lumped element model we can determine the dependence of the effective plasma frequency (the transition frequency) on the metasurface filling factor f.The change of the transition frequency vs.F spans over one order of magnitude and sets the threshold between the metamaterial (homogeneous) and the photonic crystal (diffraction-like) regime, ruling the onset of two different surface plasmon polaritons, spoof and high order.Field symmetry and spatial extension of such excitations are investigated for the possible applications of thz grid metasurfaces in bio- and chemical sensing and sub-wavelength imaging.

Journal: Scientific reports (2019)
Publication types: Journal Article
Optimization of decellularized liver matrix-modified chitosan fibrous scaffold for C3A hepatocyte culture.

Hepatocyte scaffold is an essential part in bioartificial liver device.We have designed a novel hepatocyte scaffold based on porcine liver extracellular matrix (ecm) and chitosan (cts) fabrics.This cts-ecm scaffold can improve cell adhesion and proliferation.In the present study, an orthogonal test was designed to optimize the cts/ecm composite scaffold, in which ecm concentration, edc concentration and edc to nhs ratio were taken as factors, proportion of nitrogen element and hydroxyproline content as indicators.The cytocompatibility of the novel scaffold for c3a hepatocytes was analyzed in vitro.The orthogonal test demonstrated that the optimal scaffold should be based on ecm concentration of 5 mg/m l, edc concentration of 5 mg/m l, and edc to nhs ratio 1:1.C3a hepatocytes cultured on the optimized cts-ecm scaffolds showed stronger proliferation and functionality than those on cytodex3 microcarriers (p< 0.05).The cts/ecm composite scaffold may be widely used as a promising hepatocyte culture carrier, especially in bioartificial liver support systems.

Journal: Journal of biomaterials applications (2022)
Publication types: Journal Article
Clinical characteristics of patients with listeriosis.

S to investigate the clinical characteristics of patients with listeriosis and to provide a basis for diagnosis, treatment, prevention and control of hospital infection.Methods a total of 10 inpatients, who suffered from the listeriosis in xiangya hospital, central south university from january 2013 to june 2019, were retrospectively collected for this study.The characteristics of the patients' age, gander, basic information, case type, clinical manifestations, first consultation department, days of diagnosis, infection indicator, specimen type, results of drug sensitivity, treatment plan, hospital infection or not, outcome, follow-up data were analyzed.Results two cases were pregnant women and other were non-pregnant adults among 10 patients with listeriosis.Among them, there were 3 cases with hospital acquired infection.The age of patient onset was 27-71 years old, and the time from onset to diagnosis was 5-36 days.Five cases had fever, and other 5 cases had not fever.There were headache, fatigue, local pain, and other specialized symptoms in the 10 patients.the white blood cell count,the neutrophil ratio, the inflammatory index c-reactive protein, the procalcitonin were all increased, and the erythrocyte sedimentation was accelerated in the 10 patients.all the patients were sensitive to ampicillin, penicillin g, meropenem, and compound sinomine.Conclusions listeriosis often affects the patients with low immunity, which often leads to misdiagnosis or missed diagnosis in clinic.so early prevention, early diagnosis, and early treatment can reduce mortality; it is important for departments of nosocomial infection management to manage patients' diet for avoiding outbreaks of listeriosis in hospital.

Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (2021)
Publication types: Journal Article
Targeted graphene oxide for drug delivery as a therapeutic nanoplatform against Parkinson's disease.

There has been an exponential increase in the rate of incidence of parkinson's disease (pd) with aging in the global population.Pd, the second most common neurodegenerative disorder, results from damaged dopamine neurons in the substantia nigra pars compacta (snpc), along with the deposition of abnormal α-synuclein (α-syn), and the progressive degeneration of neurons in striatal regions.Despite extensive investigations to understand the pathophysiology of pd to develop effective therapies to restrict its progression, there is currently no cure for pd.Puerarin (pue) is a natural compound with remarkable anti-pd properties.However, its poor pharmacological properties, including poor water solubility, inadequate bioavailability, and incomplete penetration of the blood-brain barrier (bbb) have restricted its use for the treatment of pd.Nevertheless, advancements in nanotechnology have revealed the potential advantages of targeted drug delivery into the brain to treat pd.Here, we used pue-loaded graphene oxide (go) nanosheets, which have an excellent drug-loading ability, modifiable surface functional groups, and good biocompatibility.Then, pue was transported across the bbb into the brain using lactoferrin (lf) as the targeting ligand, which could bind to the vascular endothelial receptor on the bbb.In vivo and in vitro results indicated that this multifunctional brain targeted drug delivery system (lf-go-pue) was an effective and safe therapy for pd.

Journal: Biomaterials science (2021)
Publication types: Journal Article
Draft Genome Sequence of Plant Growth-PromotingStreptomycessp. Strain SA51, Isolated from Olive Trees.

A streptomycete was isolated from the rhizosphere of olive trees in the autumn of 2004.Its molecular characterization showed the presence of metabolic pathways promoting plant growth and additional properties that indicate that this strain is a prospective agent for future biocontrol applicationsin planta we report here the draft genome sequence of streptomyces avermitilisstrain sa51.

Journal: Microbiology resource announcements (2020)
Publication types: Journal Article
Efficacy of Apneic Oxygenation During Pediatric Endotracheal Intubation.

Because of the abundance of complications associated with peri-intubation hypoxia, maintaining adequate oxygen saturation during endotracheal intubation (eti) is of great concern.In addition to standard preoxygenation techniques, apneic oxygenation (ao), the continuous flow of passive oxygenation, is a potential tool that can be used to eliminate hypoxia during eti.Although scarcely studied in the pediatric population, ao has proven effective in reducing the incidence of hypoxia in adult patients with minimal side effects.The objective of this study is to evaluate the use of apneic oxygenation in pediatric patients and to determine its efficacy in preventing or delaying oxygen desaturation during the apneic period of eti.Methods this literature review examines 4 studies that evaluate the practice of ao in pediatric patients.A total of 712 patients across 3 randomized control trials and 1 observational study were assigned to either a control group that did not receive any form of ao, a group that did not receive 100% fraction of inspired oxygen (fi o2), or an intervention group where various methods of ao were delivered.Results each ao method that provided 100% fi o2 saw a significantly longer time until initial desaturation when compared with those that did not receive any form of ao or those not receiving 100% fi o2.Conclusions the findings in this study confirm that the practice of ao is not only efficacious in increasing the time until initial desaturation but also reduces the overall incidence of hypoxia during laryngoscopy in children.

Journal: Pediatric emergency care (2021)
Publication types: Journal Article;Review
Employer-Led Strategies to Improve the Value of Health Spending: A Systematic Review.

To systematically review studies that evaluated the impact of employer-led efforts in the united states to improve the value of health spending, where employers have implemented changes to their health benefits to reduce costs while improving or maintaining quality.Methods we included all studies of employer-led health benefit strategies that reported outcomes for both employer health spending and employee health outcomes.Results our search returned 44 studies of employer health benefit changes that included measures of both health spending and quality.The most promising efforts were those that lowered or eliminated cost sharing for primary care or medications for chronic illnesses.High deductible health plans with a savings option appeared less promising.Conclusions more research is needed on the characteristics and contexts in which these benefit changes were implemented, and on actions that address employers' current concerns.

Journal: Journal of occupational and environmental medicine (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Systematic Review
COVID-19 vaccine acceptability and determinants among pregnant mothers attending antenatal care services at Debre Markos town public health institutions, Debre Markos Northwest Ethiopia: mixed study.

Introduction coronavirus is a communicable disease that produces severe morbidity and mortality in the globe and more than three million people died due to covid-19.Pregnant mothers are at higher risk of covid-19 viral infection, with great morbidity and mortality.Thus, the purpose of this research is to assess the level of covid-19 vaccine acceptability, determinants, and hesitancy among pregnant mothers attending antenatal care at debre markos town, public health institutions, debre markos, northwest ethiopia.Methods a mixed study was conducted among 350 pregnant mothers attending antenatal care at debre markos town health institutions and the participants were selected by consecutive sampling techniques.The collected data were entered into epi info version 7 and then exported to spss version 25 for data cleaning and analysis.The level of covid-19 vaccine acceptability was determined through descriptive statistics, whereas its determinants were identified by binary logistic regression analyses.Variables with p-value < 0.05 in multivariable were considered as significantly associated factors.The qualitative data were collected by an unstructured interviewer guide using in-depth interview data collection methods.Study participants were selected purposively until the required data was saturated.The data was analysed under selected themes based on the guide and summarized manually.Results sixty-five (18.5%) of the respondents accept the covid-19 vaccine [95% ci: 13, 23].Maternal age [aor: 3.281 (95% ci: 1.184, 9.092)], chronic medical illness [aor: 0.170 (95% ci: 0.051, .562)], information about covid-19 vaccine [aor: 4.063 (95% ci: 1.462, 11.293)], pregnancy-induced medical conditions [aor: 4.131 (95% ci: 1.055, 16.183) were identified as significant determinants of covid-19 vaccine acceptability.From the quantitative wing.The qualitative finding implied that misconception, fear of medical complications, lack of trust in its effectiveness, and religious constraints were the common reasons for vaccine hesitancy.Conclusion covid-19 vaccine acceptability by pregnant mothers attending anc at debre markos town public health institutions is very low.The health care providers and health extension workers shall create information about the covid-19 vaccine on its importance and side effects.

Journal: The Pan African medical journal (2022)
Publication types: Journal Article
Establishment and characterization of stable, diverse, fecal-derived in vitro microbial communities that model the intestinal microbiota.

Efforts to probe the role of the gut microbiota in disease would benefit from a system in which patient-derived bacterial communities can be studied at scale.We addressed this by validating a strategy to propagate phylogenetically complex, diverse, stable, and highly reproducible stool-derived communities in vitro.We generated hundreds of in vitro communities cultured from diverse stool samples in various media; certain media generally preserved inoculum composition, and inocula from different subjects yielded source-specific community compositions.Upon colonization of germ-free mice, community composition was maintained, and the host proteome resembled the host from which the community was derived.Treatment with ciprofloxacin in vivo increased susceptibility to salmonella invasion in vitro, and the in vitro response to ciprofloxacin was predictive of compositional changes observed in vivo, including the resilience and sensitivity of each bacteroides species.These findings demonstrate that stool-derived in vitro communities can serve as a powerful system for microbiota research.

Journal: Cell host & microbe (2022)
Publication types: Journal Article
The Multi-Kinase Inhibitor Lucitanib Enhances the Antitumor Activity of Coinhibitory and Costimulatory Immune Pathway Modulators in Syngeneic Models.

Lucitanib is a multi-tyrosine kinase inhibitor whose targets are associated with angiogenesis and other key cancer and immune pathways.Its antiangiogenic properties are understood, but lucitanib's immunomodulatory activity is heretofore unknown.Lucitanib exhibited such activity in vivo, increasing cd3 + , cd8 + , and cd4 + t cells and decreasing dendritic cells and monocyte-derived suppressor cells in mouse spleens.Depletion of cd8 + t cells from syngeneic mc38 colon tumor-bearing mice reduced the antitumor efficacy of lucitanib and revealed a cd8 + t-cell-dependent component of lucitanib's activity.The combination of lucitanib and costimulatory immune pathway agonists targeting 4-1bb, glucocorticoid-induced tnfr (gitr), inducible t-cell co-stimulator (icos), or ox40 exhibited enhanced antitumor activity compared with each single agent in immunocompetent tumor models.Lucitanib combined with blockade of cytotoxic t-lymphocyte-associated protein 4 (ctla-4) or programmed cell death protein-1 (pd-1) coinhibitory immune pathways also showed enhanced antitumor activity over the single agents in multiple models.In ct26 tumors, lucitanib, alone or combined with anti-pd-1, reduced cd31 + vessels and depleted f4/80 + macrophages.Combination treatment also increased the number of intratumoral t cells.Gene expression in pathways associated with immune activity was upregulated by lucitanib in mc38 tumors and further potentiated by combination with anti-pd-1.Accordingly, lucitanib, alone or combined with anti-pd-1, increased intratumoral cd8 + t-cell abundance.Lucitanib's antitumor and pharmacodynamic activity, alone or combined with anti-pd-1, was not recapitulated by specific vascular endothelial growth factor receptor-2 (vegfr2) inhibition.These data indicate that lucitanib can modulate vascular and immune components of the tumor microenvironment and cooperate with immunotherapy to enhance antitumor efficacy.They support the clinical development of lucitanib combined with immune pathway modulators to treat cancer.

Journal: Journal of immunotherapy (Hagerstown, Md. : 1997) (2022)
Publication types: Journal Article
Testing the Impact of a Collaborative, Goal-Setting, and Behavioral Telehealth Intervention on Diabetes Distress: A Randomized Clinical Trial.

Diabetes distress is underrecognized and associated with poor outcomes.This study tested whether a 12-month collaborative, goal-setting, and behavioral telehealth intervention reduced diabetes distress levels.methods:this is a secondary analysis of the healthy outcomes through patient empowerment (hope) study that included individuals (n = 225) with uncontrolled diabetes and depression living at least 20 miles from a veteran's affairs medical center.Participants were randomized to hope (intervention) or enhanced usual care (euc) with education.We evaluated diabetes distress levels as measured by the problem areas in diabetes (paid) questionnaire and its four subscales (emotional, diabetes management, social, and treatment distress) at baseline, 6, and 12 months.results:between-group analysis revealed greater improvements in hope versus euc for: 6-month paid total score (p= 0.04), emotional (p= 0.03), and social (p= 0.04) subscales; 12-month paid total score (p= 0.07) and emotional subscale (p= 0.07).Within-group comparisons showed larger effect sizes for hope compared with euc: 12-month paid total scores (0.82 vs.0.54), 6-month emotional burden (0.54 vs.0.31), and 6-month (0.32 vs.0.08) and 12-month (0.41 vs.0.12) social burdens.Repeated-measures analysis evaluating treatment group and time trended toward improvement in paid overall for hope compared with euc participants, but was not statistically significant (β= 6.96; se = 4.35;p= 0.13).discussion:clinically meaningful reductions in paid overall and the emotional and social subscales were observed in hope compared with euc participants.conclusion:further evaluation of diabetes telehealth interventions that include other facets related to diabetes distress, including treatment, diabetes management, social, and emotional burdens, is warranted.Clinical trial number.Nct01572389; clinical trial registry.

Journal: Telemedicine journal and e-health : the official journal of the American Telemedicine Association (2022)
Publication types: Journal Article;Randomized Controlled Trial;Research Support, N.I.H., Extramural;Research Support, U.S. Gov't, Non-P.H.S.
A multi-task fully deep convolutional neural network for contactless fingerprint minutiae extraction.

With the outbreak and wide spread of novel coronavirus (covid-19), contactless fingerprint recognition has attracted more attention for personal recognition because it can provide significantly higher user convenience and hygiene than the traditional contact-based fingerprint recognition.However, it is still challenging to achieve a highly accurate recognition due to the low ridge-valley contrast and pose variances of contactless fingerprints.Minutiae points are a kind of ridge flow discontinuities, and robust and accurate extraction is an important step for most automatic fingerprint recognition algorithms.Most of existing methods are based on two stages which locate the minutiae points first and then compute their directions.The two-stage method cannot make full use of location and direction information.In this paper, we propose a multi-task fully deep convolutional neural network for jointly learning the minutiae location detection and its corresponding direction computation which operates directly on the whole gray scale contactless fingerprints.The proposed method consists of offline training and online testing stages.In the training stage, a fully deep convolutional neural network is built for the tasks of minutiae detection and its direction regression, with an attention mechanism to make the direction regression branch concentrate on the minutiae points.A new loss function is proposed to jointly learn the tasks of minutiae detection and its direction regression from the whole fingerprints.In the testing stage, the trained network is applied on the whole contactless fingerprint to generate the minutiae location and direction maps.The proposed multi-task leaning method performs better than the individual single task and it operates directly on the raw gray-scale contactless fingerprints without preprocessing.The results on three contactless fingerprint datasets show the proposed algorithm performs better than other minutiae extraction algorithms and the commercial software.

Journal: Pattern recognition (2021)
Publication types: Journal Article
Real-Time Interfacial Nanothermometry Using DNA-PAINT Microscopy.

Biofunctionalized nanoparticles are increasingly used in biomedical applications including sensing, targeted delivery, and hyperthermia.However, laser excitation and associated heating of the nanomaterials may alter the structure and interactions of the conjugated biomolecules.Currently no method exists that directly monitors the local temperature near the material's interface where the conjugated biomolecules are.Here, a nanothermometer is reported based on dna-mediated points accumulation for imaging nanoscale topography (dna-paint) microscopy.The temperature dependent kinetics of repeated and reversible dna interactions provide a direct readout of the local interfacial temperature.The accuracy and precision of the method is demonstrated by measuring the interfacial temperature of many individual gold nanoparticles in parallel, with a precision of 1 k.In agreement with numerical models, large particle-to-particle differences in the interfacial temperature are found due to underlying differences in optical and thermal properties.In addition, the reversible dna interactions enable the tracking of interfacial temperature in real-time with intervals of a few minutes.This method does not require prior knowledge of the optical and thermal properties of the sample, and therefore opens the window to understanding and controlling interfacial heating in a wide range of nanomaterials.

Journal: Small (Weinheim an der Bergstrasse, Germany) (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't