syedzayyan/paper_mill_benchmark huggingface dataset:
Nanodermatology-based solutions for psoriasis: State-of-the art and future prospects.

Nanodermatology is an emerging, multidisciplinary science, arising from the convergence of nanotechnology, pharmacology, physics/biophysics, chemistry/biochemistry, chemical engineering, material science, and clinical medicine.Nanodermatology deals with (a) skin biology, anatomy, and physiology at the nanoscale ("skin nanobiology"), (b) diagnosis performed by means of novel diagnostic devices, assisted by nanobiotechnologies ("nanodiagnosis"), and (c) treatment through innovative therapeutic agents, including phototherapy ("photonanotherapy"/"photonanodermatology") and systemic/topical drug administration ("nanotherapy") at the nanoscale, and drug delivery-such as transdermal or dermal drug delivery (tddd/ddd)-enhanced and improved by nanostructures and nanodrugs ("nanodrug delivery").Nanodermatology, as a super-specialized branch of dermatology, is a quite recent specialty: the "nanodermatology society" founded by the eminent dermatologist dr.Adnan nasir, was established in 2010, with the aim of bringing together different stakeholders, including dermatologists, nanotechnology scientists, policy-makers and regulators, as well as students and medical residents.Psoriasis has a prevalence of 2-3% worldwide and imposes a severe clinical and societal burden.Nanodermatology-based solutions appear promising for the proper treatment and management of psoriasis, assisting and enhancing different steps of the process of health-care delivery: from the diagnosis to the therapeutics, paving the way for a personalized approach, based on the specific dysregulated biomarkers.

Journal: Dermatologic therapy (2019)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Review
Real-World Prescription Patterns For Patients With Young-Onset Parkinson's Disease in China: A Trend Analysis From 2014 to 2019.

Introduction pharmacotherapy is one of the main treatments for patients with young-onset parkinson's disease (yopd).Although numerous studies on the treatment of yopd have been published, the real-world prescription patterns of these populations remain unclear in china.methods a national comprehensive evaluation was performed to reveal the pharmacological treatment patterns in chinese patients with parkinson's disease from 1 january 2014 to 31 december 2019, with patients aged 21-50 years classified as having yopd for the subgroup analysis.Information on patients and drugs was extracted to analyse the demographic characteristics, prescription patterns, and levodopa equivalent daily dose (led) during disease progression.results a total of 1,134 patients with yopd were included, and the majority were aged 41-50 years.Prescription of l-dopa/benserazide and pramipexole accounted for more than 30 and 20%, respectively, in each year from 2014 to 2019.There was no difference in prescription patterns in terms of age, sex and geographical areas.Half of the patients with yopd were on monotherapy, but the proportion decreased from 2016.Correspondingly, the proportion of patients receiving polytherapy increased, especially those who were prescribed more than two anti-parkinson's disease drugs.During the disease course, led showed high variability, which increased over time.conclusion l-dopa/benserazide and pramipexole were the most frequently prescribed anti-pd drugs for patients with yopd in china.There was a slight trend in the transition from monotherapy to polytherapy.Led increased with disease duration.Thus, we provided an overview of the prescription patterns for patients with yopd in china.

Journal: Frontiers in pharmacology (2022)
Publication types: Journal Article
Erratum: Croteau et al (2021).

In the article croteau f, robbins sm, pearsall d.Hand-held shoulder strength measures correlate with isokinetic dynamometry in elite water polo players.J sport rehabil.2021;30:1233–1236, kendall τ numbers were inaccurately written in the first paragraph of the results section.In addition, statistics were inaccurately written in table 2, figure 3, and the supplemental material.The online version of this article has been corrected.The authors apologize for this error.

Journal: Journal of sport rehabilitation (2022)
Publication types: Journal Article;Published Erratum
Integrating the evidence in allergen immunotherapy: Why real-world data should be important for the practicing clinician?

Data obtained from controlled clinical trials are the gold standard for evaluation of allergen immunotherapy (ait) efficacy and safety.Less prone to biases (with a strong internal validity), they allow their use and external validation in the real world.The quantity and diversity of real-world data has increased exponentially, and access to large cohorts and electronic medical records have made this information increasingly accessible and useful for research and regulatory purposes.New retrospective database studies have confirmed the sustained benefits of grass, birch pollen, and house dust mite ait for both allergic rhinitis and asthma symptom and medication scores, the prevention of asthma (when used in nonasthmatic rhinitics), and the real rate of adverse systemic reactions.They also have addressed clinical practice issues not elsewhere analyzed, including the management of polysensitized patients with respiratory allergies and adherence to ait.Real-world evidence has its own biases and limits that need to be taken into account.In this article we present a concise summary of the literature about the role of real-world evidence in ait.

Journal: Allergy and asthma proceedings (2022)
Publication types: Journal Article
Synthesis and Characterization of Activated Carbon Co-Mixed Electrospun Titanium Oxide Nanofibers as Flow Electrode in Capacitive Deionization.

Flow capacitive deionization is a water desalination technique that uses liquid carbon-based electrodes to recover fresh water from brackish or seawater.This is a potential second-generation water desalination process, however it is limited by parameters such as feed electrode conductivity, interfacial resistance, viscosity, and so on.In this study, titanium oxide nanofibers (ti o2nf) were manufactured using an electrospinning process and then blended with commercial activated carbon (ac) to create a well distributed flow electrode in this study.Field emission scanning electron microscope (fesem), x-ray diffraction (xrd), raman spectroscopy, x-ray photoelectron spectroscopy (xps), and energy dispersive x-ray (edx) were used to characterize the morphology, crystal structure, and chemical moieties of the as-synthesized composites.Notably, the flow electrode containing 1 wt.% ti o2nf (acti o2nf 1 wt.%) had the highest capacitance and the best salt removal rate (0.033 mg/min·cm2) of all the composites.The improvement in cell performance at this ratio indicates that the nanofibers are uniformly distributed over the electrode's surface, preventing electrode passivation, and nanofiber agglomeration, which could impede ion flow to the electrode's pores.This research suggests that the physical mixture could be used as a flow electrode in capacitive deionization.

Journal: Materials (Basel, Switzerland) (2021)
Publication types: Journal Article
Association between time-to-treatment and outcomes in non-small cell lung cancer: a systematic review.

National targets for timely diagnosis and management of a potential cancer are driven in part by the perceived risk of disease progression during avoidable delays.However, it is unclear to what extent time-to-treatment impacts prognosis for patients with non-small cell lung cancer, with previous reviews reporting mixed or apparently paradoxical associations.This systematic review focuses on potential confounders in order to identify particular patient groups which may benefit most from timely delivery of care.Methods medline, embase and cochrane databases were searched for publications between january 2012 and october 2020, correlating timeliness in secondary care pathways to patient outcomes.The protocol is registered with prospero (the international prospective register of systematic reviews; id 99239).Prespecified factors (demographics, performance status, histology, stage and treatment) are examined through narrative synthesis.Results thirty-seven articles were included.All but two were observational.Timely care was generally associated with a worse prognosis in those with advanced stage disease (6/8 studies) but with better outcomes for patients with early-stage disease treated surgically (9/12 studies).In one study, patients with squamous cell carcinoma referred for stereotactic ablative radiotherapy benefited more from timely care, compared with patients with adenocarcinoma.One randomised controlled trial supported timeliness as being advantageous in those with stage i-iiia disease.Conclusion there are limitations to the available evidence, but observed trends suggest timeliness to be of particular importance in surgical candidates.In more advanced disease, survival trends are likely outweighed by symptom burden, performance status or clinical urgency dictating timeliness of treatment.

Journal: Thorax (2022)
Publication types: Journal Article;Systematic Review;Research Support, Non-U.S. Gov't
Sex-specific variation in the use of vertical habitat by a resident Antarctic top predator.

Patterns of habitat use are commonly studied in horizontal space, but this does not capture the four-dimensional nature of ocean habitats (space, depth, and time).Deep-diving marine animals encounter varying oceanographic conditions, particularly at the poles, where there is strong seasonal variation in vertical ocean structuring.This dimension of space use is hidden if we only consider horizontal movement.To identify different diving behaviours and usage patterns of vertically distributed habitat, we use hidden markov models fitted to telemetry data from an air-breathing top predator, the weddell seal, in the weddell sea, antarctica.We present evidence of overlapping use of high-density, continental shelf water masses by both sexes, as well as important differences in their preferences for oceanographic conditions.Males spend more time in the unique high-salinity shelf water masses found at depth, while females also venture off the continental shelf and visit warmer, shallower water masses.Both sexes exhibit a diurnal pattern in diving behaviour (deep in the day, shallow at night) that persists from austral autumn into winter.The differences in habitat use in this resident, sexually monomorphic antarctic top predator suggest a different set of needs and constraints operating at the intraspecific level, not driven by body size.

Journal: Proceedings. Biological sciences (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Oxidative DMSO Cyclization Cascade to Bicyclic Hydroxyketonitriles.

Thermolysis of ω-iodoalkyl-β-siloxyalkenenitriles in dmso triggers an oxidative cyclization cascade that affords highly oxygenated hydrindanones, decalones, and undecanones.The cyclization cascade is highly unusual on three counts: the cyclization installs a contiguous array of tertiary-quaternary-tertiary centers, thermolysis equilibrates a quaternary center, and the enolsilyl ether crossed-aldol proceeds without a catalyst.

Journal: The Journal of organic chemistry (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Impact of the COVID-19 Pandemic on Exercise Physiology Services in Australia: A Retrospective Audit.

Introduction the covid-19 pandemic has led to a shift in healthcare towards telehealth delivery, which presents challenges for exercise physiology services.We aimed to examine the impact of the covid-19 pandemic on the reach, efficacy, adoption and implementation of telehealth delivery for exercise physiology services by comparing australian practises before (prior to 25 january 2020) and during the covid-19 pandemic (after 25 january 2020).Methods this retrospective audit included 80 accredited exercise physiology clinicians.We examined relevant dimensions of the re-aim framework (reach, effectiveness, adoption and implementation) from the clinician perspective.Results during the covid-19 pandemic, 91% (n = 73/80) of surveyed clinicians offered telehealth delivery service, compared to 25% (n = 20/80) prior.Mean (sd) telehealth delivery per week doubled from 5 (7) to 10 (8) hours.In-person delivery decreased from 23 (11) to 15 (11) hours per week.Typical reasons for not offering telehealth delivery were client physical/cognitive incapacity (n = 33/80, 41%) and safety (n = 24/80, 30%).Clinician-reported reasons for typical clients not adopting telehealth delivery were personal preference (n = 57/71, 80%), physical capacity (n = 35/71, 49%) and access to reliable delivery platforms (n = 27/71, 38%).Zoom (n = 54/71, 76%) and telephone (n = 53/71, 75%) were the most commonly used platforms.Of the reasons contributing to incomplete treatment, lack of confidence in delivery mode was sevenfold higher for telehealth compared to in-person delivery.No serious treatment-related adverse events were reported.Conclusions during the covid-19 pandemic, telehealth delivery of exercise physiology services increased and in-person delivery decreased, which suggests the profession was adaptable and agile.However, further research determining comparative efficacy and cost-effectiveness is warranted.

Journal: Sports medicine - open (2022)
Publication types: Journal Article
150 years of dental education and research - University of Birmingham School of Dentistry.

This paper discusses the historical development of dental education and research over the last 150 years from a birmingham school of dentistry perspective.The school opened its doors to students in 1858 and has seen many changes and developments in both education and research.Looking back throughout the history, one of our greatest abilities as dental professionals is to be adaptable and the future will bring plenty of opportunity for us to demonstrate this.We have seen how resilient dentistry has been over the covid-19 pandemic, both in terms of education and research; the next 150 years will be a very exciting time to work in the field.

Journal: British dental journal (2022)
Publication types: Journal Article
Interrogation of the Plasma-Catalyst Interface via In Situ/Operando Transmission Infrared Spectroscopy.

Plasma-surface coupling has emerged as a promising approach to perform chemical transformations under mild conditions that are otherwise difficult or impossible thermally.However, a few examples of inexpensive and accessiblein situ/operandotechniques exist for observing plasma-solid interactions, which has prevented a thorough understanding of underlying surface mechanisms.Here, we provide a simple and adaptable design for a dielectric barrier discharge (dbd) plasma cell capable of interfacing with fourier transform infrared spectroscopy (ftir), optical emission spectroscopy (oes), and mass spectrometry (ms) to simultaneously characterize the surface, the plasma phase, and the gas phase, respectively.The system was demonstrated using two example applications: (1) plasma oxidation of primary amine functionalized sba-15 and (2) catalytic low temperature nitrogen oxidation.The results from application (1) provided direct evidence of a 1% o2/he plasma interacting with the aminosilica surface by selective oxidation of the amino groups to nitro groups without altering the alkyl tether.Application (2) was used to detect the evolution of noxspecies bound to both platinum and silica surfaces under plasma stimulation.Together, the experimental results showcase the breadth of possible applications for this device and confirm its potential as an essential tool for conducting research on plasma-surface coupling.

Journal: ACS engineering Au (2022)
Publication types: Journal Article
Linguistic Tone and Non-Linguistic Pitch Imitation in Children with Autism Spectrum Disorders: A Cross-Linguistic Investigation.

The conclusions on prosodic pitch features in autism spectrum disorders (asd) have primarily been derived from studies in non-tonal language speakers.This cross-linguistic study evaluated the performance of imitating cantonese lexical tones and their non-linguistic (nonspeech) counterparts by cantonese- and mandarin-speaking children with and without asd.Acoustic analyses showed that, compared with typically developing peers, children with asd exhibited increased pitch variations when imitating lexical tones, while performed similarly when imitating the nonspeech counterparts.Furthermore, mandarin-speaking children with asd failed to exploit the phonological knowledge of segments to improve the imitation accuracy of non-native lexical tones.These findings help clarify the speech-specific pitch processing atypicality and phonological processing deficit in tone-language-speaking children with asd.

Journal: Journal of autism and developmental disorders (2022)
Publication types: Journal Article
A method of assessing peripheral stent abrasiveness under cyclic deformations experienced during limb movement.

Poor outcomes of peripheral arterial disease stenting are often attributed to the inability of stents to accommodate the complex biomechanics of the flexed lower limb.Abrasion damage caused by rubbing of the stent against the artery wall during limb movement plays a significant role in reconstruction failure but has not been characterized.Our goals were to develop a method of assessing the abrasiveness of peripheral nitinol stents and apply it to several commercial devices.Misago, absolute pro, innova, zilver, smart control, smart flex, and supera stents were deployed inside electrospun nanofibrillar tubes with femoropopliteal artery-mimicking mechanical properties and subjected to cyclic axial compression (25%), bending (90°), and torsion (26°/cm) equivalent to five life-years of severe limb flexions.Abrasion was assessed using an abrasion damage score (ads, range 1-7) for each deformation mode.Misago produced the least abrasion and no stent fractures (ads 3).Innova caused small abrasion under compression and torsion but large damage under bending (ads 7).Supera performed well under bending and compression but caused damage under torsion (ads 8).Absolute pro produced significant abrasion under bending and compression but less damage under torsion (ads 12).Zilver fractured under all three deformations and severely abraded the tube under bending and compression (ads 15).Smart control and smart flex fractured under all three deformations and produced significant abrasion due to strut penetration (ads 20 and 21).Ads strongly correlated with clinical 12-month primary patency and target lesion revascularization rates, and the described method of assessing peripheral stent abrasiveness can guide device selection and development.Statement of significance: poor outcomes of peripheral arterial disease stenting are related to the inability of stents to accommodate the complex biomechanics of the flexed lower limb.Abrasion damage caused by rubbing of the stent against the artery wall during limb movement plays a significant role in reconstruction failure but has not been characterized.Our study presents the first attempt at assessing peripheral stent abrasiveness, and the proposed method is applied to compare the abrasion damage caused by misago, absolute pro, innova, zilver, smart control, smart flex, and supera peripheral stents using artery-mimicking synthetic tubes and cyclic deformations equivalent to five life-years of severe limb flexions.The abrasion damage caused by stents strongly correlates with their clinical 12-month primary patency and target lesion revascularization rates, and the described methodology can be used as a cost-effective and controlled way of assessing stent performance, which can guide device selection and development.

Journal: Acta biomaterialia (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Biotransformation of 2,4,6-trinitrotoluene by Diaphorobacter sp. strain DS2.

Diaphorobacter strain ds2 degrades 3-nitrotoluene and 2-nitrotoluene via ring oxidation with 3-nitrotoluene dioxygenase (3ntdo).In the current study, we hypothesized that 3ntdo might also be involved in the degradation of 2,4,6-trinitrotoluene (tnt), a major nitroaromatic explosive contaminant in soil and groundwater.Strain ds2 transforms tnt as a sole carbon and nitrogen source when grown on it.Ammonium chloride and succinate in the medium accelerated the tnt degradation rate.A resting cell experiment suggested that tnt does not compete with 3nt degradation (no negative impact of tnt on the reaction velocity for 3nt).Enzyme assay with 3ntdo did not exhibit tnt transformation activity.The above results confirmed that 3ntdo of ds2 is not responsible for tnt degradation.In the resting cell experiment, within 10 h, 4adnt completely degraded.The degradation of 2adnt was 97% at the same time.We hypothesized that 3ntdo involve in this reaction.Based on the ds2 genome, we proposed that the n-ethylmaleimide reductases (nem a) were involved in the initial reduction of the nitro group and aromatic ring of tnt.Our findings suggest that strain ds2 could be helpful for the removal of tnt from contaminated sites with or without any additional carbon and nitrogen source and with minimal accumulation of undesirable intermediates.

Journal: Environmental science and pollution research international (2023)
Publication types: Journal Article
Understanding religious attachment among christians seeking spiritually integrated psychotherapies: A mixed methods study.

This mixed methods study aimed to understand ways of viewing and experiencing religious attachment among christians in spiritually integrated psychotherapies.Method in total, 190 christian-affiliated clients completed narrative responses about religious and parental attachment along with validated measures of spiritual and psychological functioning toward the start of treatment.Results an inductive content analysis revealed ten ways in which clients were viewing and experiencing god.Although painful themes were expressed, clients more frequently discussed comforting themes related to religious attachment.Additional analyses demonstrated convergence with parental attachment and quantitative measures of spirituality and mental health.Conclusion religious attachment appears to primarily provide a sense of strength and comfort for christians seeking care.Findings also indicate clients view and experience god in similar ways as their parents or caregivers.As such, assessing and affirming clients' faith may facilitate positive changes in how they view and experience themselves and others in treatment.

Journal: Journal of clinical psychology (2022)
Publication types: Journal Article
Tetrahalidometallate(II) Ionic Liquids with More than One Metal: The Effect of Bromide versus Chloride.

Fifteen n-butylpyridinium salts - five monometallic [c4py]2[mbr4] and ten bimetallic [c4py]2[m0.5a m0.5b br4] (m=co, cu, mn, ni, zn) - were synthesized, and their structures and thermal and electrochemical properties were studied.All the compounds are ionic liquids (ils) with melting points between 64 and 101 °c.Powder and single-crystal x-ray diffraction show that all ils are isostructural.The electrochemical stability windows of the ils are between 2 and 3 v.The conductivities at room temperature are between 10-5and 10-6s cm-1.At elevated temperatures, the conductivities reach up to 10-4s cm-1at 70 °c.The structures and properties of the current bromide-based ils were also compared with those of previous examples using chloride ligands, which illustrated differences and similarities between the two groups of ils.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (2022)
Publication types: Journal Article