syedzayyan/paper_mill_benchmark huggingface dataset:
Effect of Different Doses of Buprenorphine in Combination with Bupivacaine in the Management of Postoperative Analgesia: A Comparative Study.

Longer duration of analgesia, ceiling effect on respiratory depression, and the antihyperalgesia property make buprenorphine a good adjuvant for managing moderate-to-severe postoperative pain.Aims the aim of this study is to evaluate the onset and duration of postoperative analgesia of three different doses of buprenorphine of 60, 100, and 150 μg given intrathecally along with hyperbaric bupivacaine in patients undergoing lower limb surgeries.Setting and design this prospective observational study was carried out in the anesthesia department of a tertiary care hospital.Materials and methods the study included 90 patients of either sex, aged 18-60 years, scheduled for elective lower limb surgery under subarachnoid block.Patients were randomly allocated into three groups (30 each) receiving different doses of buprenorphine.In addition, all patients received 3 m l of 0.5% hyperbaric bupivacaine.Statistical analysis used the chi-square test or fisher's exact test was used to find out the association between the categorical variables.The association of quantitative variables between the groups was assessed by kruskal-wallis test while within the groups was assessed by repeated-measures analysis of variance test.Results baseline characteristics such as age, gender, and american society of anesthesiologist physical status classification were comparable among the three groups.Sensory block, motor block, and total duration of analgesia were significantly higher with higher doses of buprenorphine.The mean difference in the duration of analgesia was comparable in patients receiving 100 μg (720 min) and 150 μg (825 min) of buprenorphine.Bradycardia as a side effect was only in patients receiving 150 μg of buprenorphine.Conclusion risk-benefit of different doses of buprenorphine suggests that 100 μg may be the ideal dose for a better quality of spinal block and maintaining hemodynamic stability.

Journal: Anesthesia, essays and researches (2022)
Publication types: Journal Article
A Multidisciplinary Assessment of Remote Myocardial Fibrosis After Reperfused Myocardial Infarction in Swine and Patients.

In extensive nonreperfused myocardial infarction (mi), remote fibrosis has been documented.Early reperfusion by primary angioplasty represents the gold standard method to minimize the extension of the infarction.We aimed to ascertain whether fibrosis also affects remote regions in reperfused mi in swine and patients.Swine were subjected to a transient occlusion of the left anterior descending artery followed by 1-week or 1-month reperfusion.Collagen content in the remote area macroscopically, microscopically, by magnetic resonance microimaging, and at the molecular level was similar to controls.In patients with previous mi, samples from autopsies displayed a significant increase in collagen content only in the infarct region.In patients with previous mi submitted to cardiac magnetic resonance-t1 mapping, the extracellular volume fraction in remote segments was similar to that for controls.In all scenarios, the remote region did not show a significant increase of collagen content in comparison with controls.

Journal: Journal of cardiovascular translational research (2016)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Incidence of dural sac puncture during neuraxial anesthesia in cats: an observational, retrospective study.

S the aim of this study was to determine the occurrence of dural puncture, indicated by cerebrospinal fluid (csf) outflow, in cats receiving neuraxial anesthesia through a lumbosacral injection guided by a pop sensation method.Methods this was an observational, retrospective study.Cats that were scheduled for lumbosacral neuraxial anesthesia were included.Medical records were analyzed to investigate: (1) demographic data; (2) neuraxial anesthesia performed (epidural/spinal); (3) type of needle used, including gauge and length; (4) presence of csf (yes/no) and/or blood (yes/no) in the hub of the needle; and (5) flicking of the tail during needle advancement (yes/no).Results a total of 94 medical records were analyzed.A 22 g 50 mm tuohy needle was used in all cats scheduled for an epidural injection (n = 60), whereas a 22 g 40 mm quincke needle was used in all cats scheduled for an intrathecal injection (n = 34).Csf outflow was detected in 55/60 (91.7%) cats in which a tuohy needle was used, and 34/34 (100%) of the cats in which a quincke needle was used (p= 0.15).Flicking of the tail was detected in 41/60 (68.3%) and in 24/34 (70.6%) injections with tuohy and quincke needles, respectively (p>0.99).Traces of blood, but not active blood outflow, were detected via staining of the first drops of csf in 2/34 cats in which quincke needles were used and in none of the cats in which tuohy needles were used (p= 0.12).Conclusions and relevance this study shows that the lumbosacral approach for neuraxial anesthesia in cats may result in a dural sac puncture when 22 g quincke or tuohy needles are used.The pop sensation method should be deemed effective in predicting intrathecal but not epidural needle placement.

Journal: Journal of feline medicine and surgery (2022)
Publication types: Journal Article;Observational Study;Observational Study, Veterinary
Examining the relationship between land surface temperature and landscape features using spectral indices with Google Earth Engine.

Land surface temperature (lst) is strongly influenced by landscape features as they change the thermal characteristics of the surface greatly.Normalized difference vegetation index (ndvi), normalized difference water index (ndwi), normalized difference built-up index (ndbi), and normalized difference bareness index (ndbai) correspond to vegetation cover, water bodies, impervious build-ups, and bare lands, respectively.These indices were utilized to demonstrate the relationship between multiple landscape features and lst using the spectral indices derived from images of landsat 5 thematic mapper (tm), and landsat 8 operational land imager (oli) of sylhet sadar upazila (2000-2018).Google earth engine (gee) cloud computing platform was used to filter, process, and analyze trends with logistic regression.Lst and other spectral indices were calculated.Changes in lst (2000-2018) range from -6 °c to +4 °c in the study area.Because of higher vegetation cover and reserve forest, the north-eastern part of the study region had the greatest variations in lst.The spectral indices corresponding to landscape features have a considerable explanatory capacity for describing lst scenarios.The correlation of these indices with lst ranges from -0.52 (ndbi) to +0.57 (ndvi).

Journal: Heliyon (2022)
Publication types: Journal Article
Minimally invasive carpal tunnel release: A clinical case study and surgical technique.

Introduction and importance carpal tunnel syndrome (cts) is the most prevalent type of median nerve entrapment neuropathy.Ctr surgery with a single limited incision is becoming more widely accepted.A better recovery, less pillar pain, less scarring, and an earlier return to work are the key benefits of single limited incision.This study provides an inquiry report on the surgical method, surgical advice, and outcomes of single limited incision minimally invasive carpal tunnel release for cts.Case presentation a 60-year-old female developed carpal tunnel syndrome (cts).Patient received minimally invasive carpal tunnel release using single limited incision following the failure non operative treatment and the patient was able to return to work with excellent 1-year outcomes.The patient was extremely satisfied with this operative technique.Clinical discussion this case highlights a successful outcome of a minimal invasive surgery in cts.Visual efficiency during surgery and full transverse carpal ligament release are both improved with this technique which requires only a single limited incision.The transverse carpal ligament is totally released with this approach.During the operation, median nerves and superficial palmar arches are not injured.Conclusion this technique has been shown to be effective and safe for minimal invasive surgery.This technique could be of interest to surgeons performing minimal invasive surgery who treat cts.

Journal: Annals of medicine and surgery (2012) (2022)
Publication types: Case Reports;Journal Article
The pandemic toll and post-acute sequelae of SARS-CoV-2 in healthcare workers at a Swiss University Hospital.

Healthcare workers have potentially been among the most exposed to sars-co v-2 infection as well as the deleterious toll of the pandemic.This study has the objective to differentiate the pandemic toll from post-acute sequelae of sars-co v-2 infection in healthcare workers compared to the general population.The study was conducted between april and july 2021 at the geneva university hospitals, switzerland.Eligible participants were all tested staff, and outpatient individuals tested for sars-co v-2 at the same hospital.The primary outcome was the prevalence of symptoms in healthcare workers compared to the general population, with measures of covid-related symptoms and functional impairment, using prevalence estimates and multivariable logistic regression models.Healthcare workers (n = 3083) suffered mostly from fatigue (25.5 %), headache (10.0 %), difficulty concentrating (7.9 %), exhaustion/burnout (7.1 %), insomnia (6.2 %), myalgia (6.7 %) and arthralgia (6.3 %).Regardless of sars-co v-2 infection, all symptoms were significantly higher in healthcare workers than the general population (n = 3556).Sars-co v-2 infection in healthcare workers was associated with loss or change in smell, loss or change in taste, palpitations, dyspnea, difficulty concentrating, fatigue, and headache.Functional impairment was more significant in healthcare workers compared to the general population (a or 2.28; 1.76-2.96), with a positive association with sars-co v-2 infection (a or 3.81; 2.59-5.60).Symptoms and functional impairment in healthcare workers were increased compared to the general population, and potentially related to the pandemic toll as well as post-acute sequelae of sars-co v-2 infection.These findings are of concern, considering the essential role of healthcare workers in caring for all patients including and beyond covid-19.

Journal: Preventive medicine reports (2022)
Publication types: Journal Article
Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema.

To quantitatively detect aqueous levels of angiopoietin-like (angptl)3, angptl4, and angptl6 and investigate their correlation with optical coherence tomography angiography (octa) findings in patients with diabetic macular edema (dme).Methods this cross-sectional study included 23 patients (27 eyes) with type 2 diabetes and 16 control subjects (20 eyes).All patients underwent octa imaging and ultra-wide field fundus photography.Diabetic patients were categorized into two groups according to the presence or absence of diabetic retinopathy (dme group, 14 patients, 16 eyes); and non-diabetic retinopathy (ndr) group, 9 patients, 11 eyes, respectively.Aqueous levels of angptl3, angptl4, and angptl6 were assessed using suspension array technology, and foveal-centered 3×3 mm2octa scans were automatically graded to determine the central, inner, and full vessel density (cvd, ivd, fvd); central, inner, and full perfusion density (cpd, ipd, fpd), foveal avascular zone (faz) area, faz perimeter, and faz circularity index (faz-ci) on superficial capillary plexuses.Additionally, central subfield thickness (cst), cube volume (cv), and cube average thickness (cat) were measured in a model of macular cube 512×128.Results aqueous angptl3 levels were not significantly different among the three groups (p>0.05).Angptl4 levels were significantly higher in the dme group than the control and ndr groups (p<0.0001 and p<0.001), while angptl6 levels were significantly higher in the dme group than the control group (p<0.05).In the whole cohort, the aqueous angptl3 levels correlated negatively with the ivd, fvd, ipd, and fpd, and positively with the cv and cat.The aqueous angptl4 levels correlated negatively with the cvd, ivd, fvd, cpd, ipd, and fpd, and positively with the faz perimeter, cst, cv, and cat.The aqueous angptl6 levels correlated negatively with the ivd, fvd, ipd, fpd, faz-ci and positively with cst, cv, cat.Conclusion angptl4 and angptl6 may be associated with vascular leakage in dme and may represent good targets for dme therapy.In addition, octa metrics may be useful for evaluating macular ischemia in dme.

Journal: International journal of ophthalmology (2021)
Publication types: Journal Article
Predictors and clinical outcomes of post-coronary artery bypass grafting cerebrovascular strokes.

Despite the improved medical and surgical managements, still there is a significant risk of developing acute cerebrovascular strokes after coronary artery bypass grafting (cabg).Our objectives were to study the immediate and long-term outcomes after cabg and to identify the possible predictors of post-cabg strokes.Results between january 2016 and august 2020, 410 adult patients, mostly males (82.2%), were retrospectively enrolled after cabg.Acute postoperative strokes occurred in 31 (7.5%) patients; of them, 30 (96.8%) patients had ischemic stroke, while 1 (3.2%) had hemorrhagic stroke.Mechanical thrombectomy was done in two cases.The patients who developed acute cerebral stroke had significantly higher admission (p = 0.02) and follow-up (p < 0.001) sofa scores, higher arterial blood lactate level (p < 0.001), longer hospitalization (p < 0.001) and more hospital mortality (p < 0.001) compared with the patients who did not develop stroke.Kaplan-meier curves for 5-year mortality showed increased risk in those patients with postoperative stroke (hr: 23.03; 95% ci: 6.10-86.92, p < 0.001).After multivariate regression, the predictors of early postoperative stroke were carotid artery stenosis (cas), postoperative atrial fibrillation, cardiopulmonary bypass time, prior cerebral stroke, admission sofa score and chronic kidney disease (ckd).The predictors of late cerebrovascular stroke were cas, combined cabg and valve surgery, ckd, atrial fibrillation, prior stroke and hb a1c.Conclusions the development of post-cabg acute cerebrovascular stroke is associated with longer hospitalization, multiple morbidities and increased mortality.Careful assessment and management of risk factors especially atrial fibrillation and carotid artery stenosis should be implemented to decrease this substantial complication after cabg.

Journal: The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology (2022)
Publication types: Journal Article
First Report of Chlamydia Seroprevalence in Farmed Wild Boars in China.

Chlamydia is gram-negative obligate bacterium, which can cause human diseases worldwide and has huge economic impact on animals.It is yet to know whether farmed wild boars are infected with chlamydia in china.To assess risk factors of chlamydia infection in farmed wild boars in china, from april 2015 to february 2016, a total of 837 serum samples of farmed wild boars were collected in jilin province, northeastern china, and antibodies against chlamydia were examined by the indirect hemagglutination assay.The investigation showed that antibodies to chlamydia were detected in 332 (39.67%, 95% ci 33.36-42.98) of 837 serum samples of farmed wild boars, seroprevalence ranged from 33.71% to 44.42% among different regions and the differences were statistically significant by spss analysis (p = 0.0248).These results indicated that chlamydia is highly prevalent in farmed wild boars in jilin province, northeastern china, and may pose a potential risk for human health.To our knowledge, this is the first report of chlamydia seroprevalence in farmed wild boars in china, which provided baseline data for preventing and controlling chlamydia infection in wild boars in china.

Journal: Vector borne and zoonotic diseases (Larchmont, N.Y.) (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Scalable 3D Honeycombed Co3O4Modified Separators as Polysulfides Barriers for High-Performance Li-S Batteries.

Lithium sulfur batteries (lsbs) are regarded as one of the most promising energy storage devices due to the high theoretical capacity and energy density.However, the shuttling lithium polysulfides (li pss) from the cathode and the growing lithium dendrites on the anode limit the practical application of lsbs.To overcome these challenges, a novel three-dimensional (3d) honeycombed architecture consisting of a local interconnected co3o4successfully assembled into a scalable modified layer through mutual support, which is coated on commercial separators for high-performance lsbs.On the basis of the 3d honeycombed architecture, the modified separators not only suppress effectively the "shuttle effects" but also allow for fast lithium-ions transportation.Moreover, the theoretical calculations results exhibit that the collaboration of the exposed (111) and (220) crystal planes of co3o4is able to effectively anchor li pss.As expected, lsbs with 3d honeycombed co3o4modified separators present a reversible specific capacity with 1007 m ah g-1over 100 cycles at 0.1 c.More importantly, a high reversible capacity of 808 m ah g-1over 300 cycles even at 1 c is also acquired with the modified separators.Therefore, this proposed strategy of 3d honeycombed architecture co3o4modified separators will give a new route to rationally devise durable and efficient lsbs.

Journal: ACS applied materials & interfaces (2022)
Publication types: Journal Article
Balanced-ternary-inspired reconfigurable vortex beams using cascaded metasurfaces.

Electromagnetic vortex carries the orbital angular momentum, one of the most fundamental properties of waves.The order of such vortex can be unbounded in principle, thus facilitating high-capability wave technologies for optical communications, photonic integrated circuits and others.However, it remains a key challenge to generate the high-order vortex beams in a reconfigurable, broadband and cost-effective manner.Here, inspired by the balanced-ternary concept, we demonstrate the reconfigurable generation of order-controllable vortices via cascaded n-layer metasurfaces.We theoretically showed that3n-1different vortex modes can be generated by cascading nmetasurfaces, each one serving as an individual vortex beam generator for the order of3k(k= 0,1,2 ...,n-1).As a proof-of-concept demonstration, a reconfigurable generation of 26 different vortex beams, with orders from 1 to 13 and from -1 to -13, is showcased in a broad millimeter-wave region by a cascade of 3 metasurfaces.Our method can be easily extended to vortex beam generator of arbitrary orders in a reconfigurable and easily implementable manner, paving a new avenue towards tremendous practical applications.

Journal: Nanophotonics (Berlin, Germany) (2022)
Publication types: Journal Article
Outcomes of On-Label Reduced-Dose Edoxaban in Patients With Atrial Fibrillation: The LEDIOS Registry.

Non-vitamin k antagonist oral anticoagulants (noacs) are effective in preventing thromboembolisms and reduce the risk of bleeding compared with warfarin.There are few reports on the outcomes of on-label reduced-dose noacs.The aim of this study was to assess the safety and efficacy of on-label reduced-dose edoxaban in patients with atrial fibrillation (af).Methods this study is a multi-center, prospective, non-interventional study to evaluate the safety and efficacy of on-label reduced-dose edoxaban in patients with af.We evaluated outcomes of major bleeding, stroke or systemic embolism, all-cause death, and composite clinical outcomes.Results a total of 2,448 patients (mean age 75.0 ± 8.3 years, 801 [32.7%] males) was included in the present study.The mean cha2ds2-vasc score was 3.7 ± 1.5.Major bleeding events occurred at a rate of 1.34%/yr.The event rate of strokes and systemic embolisms was 1.13%/yr.The overall net clinical outcomes occurred at a rate of 3.19%/yr.There were no significant differences according to the number of dose reduction criteria, renal dysfunction, or body weight.Higher has-bled score and higher combination of cha2ds2-vasc and has-bled score was associated with an increased risk of composite clinical outcomes compared to the lower score groups.Conclusions this study was the largest prospective real-world study to investigate the safety and efficacy of on-label low-dose edoxaban in an asian population.Reduced-dose edoxaban can be used safely in patients with severe renal dysfunction or extremely low body weight.Our observation suggests that physicians should consider bleeding risk even in a low-dose regimen.Trial registration clinical trials.gov identifier: nct03554837.

Journal: Journal of Korean medical science (2022)
Publication types: Clinical Trial;Journal Article
Survival characteristics and transcriptome profiling reveal the adaptive response of theBrucella melitensis16M biofilm to osmotic stress.

Brucellacan inhabit hostile environments, including osmotic stress.How brucellaresponds collectively to osmotic stress is largely unexplored, particularly in spatially structured communities such as a biofilm.To gain insight into this growth mode, we set out to characterize the brucella melitensis16m biofilm, describe its phenotype, and carry out a comparative transcriptomic analysis between biofilms under osmotic stress and control conditions.We determined that the bacteria challenged with 1.5 m na cl had a reduced ability to aggregate and form clumps and develop a biofilm; however, the salt stress promoted the release of the outer membrane vesicles from the biofilm.Together with the genotypical response to osmotic stress, we identified 279 differentially expressed genes in b.Melitensis16m grown under osmotic conditions compared with control conditions; 69 genes were upregulated and 210 downregulated.Under osmotic stress, the main changed genes of biofilm were predicted to be involved in flagellar assembly, cell envelope, translation, small rna regulation, transport and binding proteins, and energy metabolism.In addition, the abc transporter was enriched in the gene ontology (go) and kyoto encyclopedia of genes and genomes (kegg) pathways.We highlight 12 essential abc transporter genes associated with a bacterial response to osmotic stress at the biofilm stage, including one specific locus, bme_rs12880, mediating betaine accumulation in biofilms to eliminate osmotic stress.The current study results can help researchers gain insights into b.Melitensis16m biofilm adaptation to osmotic stress and provide information for developing intervention strategies to control brucella.

Journal: Frontiers in microbiology (2022)
Publication types: Journal Article