syedzayyan/paper_mill_benchmark huggingface dataset:
Adiponectin as a novel biomarker of disease severity in alopecia areata.

The frequent coexistence of obesity and metabolic syndrome in patients with alopecia areata may indicate the common pathogenetic pathway in these conditions with an important role of adipokines.The aim of the study was to evaluate the serum level of adiponectin, resistin and leptin in patients with alopecia areata in comparison to healthy controls.The study included 65 patients with alopecia areata and 71 healthy controls.The concentration of adipokines was determined with the enzyme-linked immunosorbent assay.The mean concentrations of adiponectin and resistin were significantly lower in the sera of patients with alopecia areata when compared to healthy controls (7966 [formula: see text] 4087 vs 9947 [formula: see text] 5692 ng/ml; p = 0.0312 and 11.04 [formula: see text] 3.88 vs 14.11 [formula: see text] 8.69 ng/ml; p = 0.0176, respectively).A negative correlation between the serum level of adiponectin and severity of alopecia tool (salt) score was observed (r = - 0.26; p < 0.05).The concentration of adiponectin was significantly lower in patients with alopecia universalis than in patients with patchy alopecia areata (4951 [formula: see text] 2499 vs 8525 [formula: see text] 4085 ng/ml; p = 0.0135).No significant difference in the serum concentration of leptin was observed between patients with alopecia areata and healthy controls.The negative correlation between the serum level of adiponectin and hair loss severity indicates that adiponectin may be considered a marker of hair loss severity in alopecia areata.Further studies are needed to evaluate the role of resistin in patients with alopecia areata and its decreased level irregardless of severity or activity of the disease.

Journal: Scientific reports (2021)
Publication types: Journal Article
A parallel classification strategy to simultaneous control elbow, wrist, and hand movements.

In the field of myoelectric control systems, pattern recognition (pr) algorithms have become always more interesting for predicting complex electromyography patterns involving movements with more than 2 degrees of freedom (do fs).The majority of classification strategies, used for the prosthetic control, are based on single, hierarchical and parallel linear discriminant analysis (lda) classifiers able to discriminate up to 19 wrist/hand gestures (in the 3-do fs case), considering both combined and discrete motions.However, these strategies were introduced to simultaneously classify only 2 do fs and their use is limited by the lack of online performance measures.This study introduces a novel classification strategy based on the logistic regression (lr) algorithm with regularization parameter to provide simultaneous classification of 3 do fs motion classes.Methods the parallel pr-based strategy was tested on 15 healthy subjects, by using only six surface emg sensors.Twenty-seven discrete and complex elbow, hand and wrist motions were classified by keeping the number of electromyographic (emg) electrodes to a bare minimum and the classification error rate under 10 %.To this purpose, the parallel classification strategy was implemented by using three classifiers one for each do f: the "elbow classifier", the "wrist classifier", and the "hand classifier" provided the simultaneous control of the elbow, hand, and wrist joints, respectively.Results both the offline and real-time performance metrics were evaluated and compared with the lda parallel classification results.The real-time recognition results were statistically better with the lr classifier with respect to the lda classifier, for all motion classes (elbow, hand and wrist).Conclusions in this paper, a novel parallel pr-based strategy was proposed for classifying up to 3 do fs: three joint classifiers were employed simultaneously for classifying 27 motion classes related to the elbow, wrist, and hand and promising results were obtained.

Journal: Journal of neuroengineering and rehabilitation (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Design of effective self-powered SnS2/halide perovskite photo-detection system based on triboelectric nanogenerator by regarding circuit impedance.

Self-powered detectors based on triboelectric nanogenerators (teng) have been considered because of their capability to convert ambient mechanical energy to electrical out-put signal, instead of conventional usage of electrochemical batteries as power sources.In this regard, the self-powered photodetectors have been designed through totally two lay out called passive and active circuit.In former model, impedance matching between the teng and the resistance of the circuit's elements is crucial, which is not investigated systematically till now.In this paper, a cost effective novel planar photodetector (pd) based on heterojunction of sn s2sheets and cs0.05(fa0.83ma0.17)0.95pb(i0.83br0.17)3three cationic lead iodide based perovskite (pvk) layer fabricated which powered by graphene oxide (go) paper and kapton based contact-separated teng (cs-teng).To achieve the high performance of this device, the proper range of the load resistances in the circuit regards to teng's characterization has been studied.In the next steps, the integrated self-powered photo-detection system was designed by applying kapton/fto and hand/fto teng, separately, in the proposed impedance matching circuit.The calculated d* of integrated self-powered sn s2/pvk supplied by tapping the kapton and hand on fto is 2.83 × 1010and 1.10 × 1013jones under the 10 m w/cm2of white light intensity, the investigations determine that for designing significate performance of self-powered pd supplied by teng, the existence of the load resistance with the well match amount to the utilized teng is crucial.Our results which can be generalized to other types of passive self-powered sensors, are substantial to both academia and industry concepts.

Journal: Scientific reports (2022)
Publication types: Journal Article
Fucoidan-loaded nanofibrous scaffolds promote annulus fibrosus repair by ameliorating the inflammatory and oxidative microenvironments in degenerative intervertebral discs.

Tissue engineering holds potential in the treatment of intervertebral disc degeneration (idd).However, implantation of tissue engineered constructs may cause foreign body reaction and aggravate the inflammatory and oxidative microenvironment of the degenerative intervertebral disc (ivd).In order to ameliorate the adverse microenvironment of idd, in this study, we prepared a biocompatible poly (ether carbonate urethane) urea (pecuu) nanofibrous scaffold loaded with fucoidan, a natural marine bioactive polysaccharide which has great anti-inflammatory and antioxidative functions.Compared with pure pecuu scaffold, the fucoidan-loaded pecuu nanofibrous scaffold (f-pecuu) decreased the gene and protein expression related to inflammation and the oxidative stress in the lipopolysaccharide (lps) induced annulus fibrosus cells (afcs) significantly (p<0.05).Especially, gene expression of il 6 and ptgs2 was decreased more than 50% in f-pecuu with 3.0 wt% fucoidan (hf-pecuu).Moreover, the gene and protein expression related to the degradation of extracellular matrix (ecm) were reduced in a fucoidan concentration-dependent manner significantly, with increased almost 3 times gene expression of col1a1 and acan in hf-pecuu.Further, in a 'box' defect model, hf-pecuu decreased the expression of cox-2 and deposited more ecm between scaffold layers when compared with pure pecuu.The disc height and nucleus pulposus hydration of repaired ivd reached up to 75% and 85% of those in the sham group.In addition, f-pecuu helped to maintain an integrate tissue structure with a similar compression modulus to that in sham group.Taken together, the f-pecuu nanofibrous scaffolds showed promising potential to promote af repair in idd treatment by ameliorating the harsh degenerative microenvironment.Statement of significance: annulus fibrosus (af) tissue engineering holds potential in the treatment of intervertebral disc degeneration (idd), but is restricted by the inflammatory and oxidative microenvironment of degenerative disc.This study developed a biocompatible polyurethane scaffold (f-pecuu) loaded with fucoidan, a marine bioactive polysaccharide, for ameliorating idd microenvironment and promoting disc regeneration.F-pecuu alleviated the inflammation and oxidative stress caused by lipopolysaccharide and prevented extracellular matrix (ecm) degradation in af cells.In vivo, it promoted ecm deposition to maintain the height, water content and mechanical property of disc.This work has shown the potential of marine polysaccharides-containing functional scaffolds in idd treatment by ameliorating the harsh microenvironment accompanied with disc degeneration.

Journal: Acta biomaterialia (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The fractional amplitude of low-frequency fluctuations signals related to amyloid uptake in high-risk populations-A pilot fMRI study.

Patients with type 2 diabetes mellitus (t2dm) and subjective cognitive decline (scd) have a higher risk to develop alzheimer's disease (ad).Resting-state-functional magnetic resonance imaging (rs-f mri) was used to document neurological involvement in the two groups from the aspect of brain dysfunction.Accumulation of amyloid-β (aβ) starts decades ago before the onset of clinical symptoms and may already have been associated with brain function in high-risk populations.However, this study aims to compare the patterns of fractional amplitude of low-frequency fluctuations (f alff) maps between cognitively normal high-risk groups (scd and t2dm) and healthy elderly and evaluate the association between regional amyloid deposition and local f alff signals in certain cortical regions.Materials and methods a total of 18 t2dm, 11 scd, and 18 healthy elderlies were included in this study.The differences in the f alff maps were compared between hc and high-risk groups.Regional amyloid deposition and local f alff signals were obtained and further correlated in two high-risk groups.Results compared to hc, the altered f alff signals of regions were shown in scd such as the left posterior cerebellum, left putamen, and cingulate gyrus.The t2dm group illustrated altered neural activity in the superior temporal gyrus, supplementary motor area, and precentral gyrus.The correlation between f alff signals and amyloid deposition was negative in the left anterior cingulate cortex for both groups.In the t2dm group, a positive correlation was shown in the right occipital lobe and left mesial temporal lobe.Conclusion the altered f alff signals were demonstrated in high-risk groups compared to hc.Very early amyloid deposition in scd and t2dm groups was observed to affect the neural activity mainly involved in the default mode network (dmn).

Journal: Frontiers in aging neuroscience (2022)
Publication types: Journal Article
Managing an altered social context-Patients experiences of staying away from home while undergoing proton beam therapy.

To illuminate the experience of an altered social context for patients with primary brain tumours living away from home while undergoing proton beam therapy.Design a descriptive, qualitative cross-sectional interview study.Methods nineteen patients were interviewed between december 2015-august 2016, either during (n= 7) or before and after (n= 12) their proton beam therapy.A hermeneutical analysis was performed.Results participants made adjustments to achieve control and well-being during the treatment period.The analysis also revealed two interrelated patterns that helped participants adjust: being part of the family from a distance and seeking affinity.Conclusion it is important that patients receiving treatment far from home find a way to remain a part of their family and find affinity in the altered social context.Health professionals can prepare patients for the treatment period and can implement interventions to promote well-being for both patients and their relatives.

Journal: Nursing open (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Cardioprotective effect of Hrudroga Chintamani Rasa in isoproterenol induced cardiotoxicity in male Sprague Dawley rats.

Ayurvedic system, a traditional medicinal system has mentioned a preparation bruhat vata chintamani rasa (suvarnayukta) for management of heart diseases.hrudroga chintamani rasa (hcr) is a formulation containing bruhat vata chintamani rasa and a few additional ingredients having beneficial effects in heart diseases.The present study was designed to investigate the cardioprotective activity of the hrudroga chintamani rasa in isoproterenol (iso)-induced myocardial infarction in rats.Methods male sprague dawley rats were treated with hcr at a dose of 56.16 and 112.32 mg/kg for 30 days.Animals received iso (85 mg/kg.s.c.) on 28th and 29th day at an interval of 24 h.Result disease control animals treated with hcr at a dose of 56.16 mg/kg and 112.32 mg/kg to rats showed a significant reduction in elevated levels of aspartate aminotransferase (ast), lactate dehydrogenase (ldh), and creatine phosphokinase mb (ck-mb), and prevented loss of depleted antioxidant enzymes from the cardiac tissue.Iso-altered electrocardiogram pattern and haemodynamic parameters were also brought about to normal by treatment with hcr.Hcr treatment also improved the levels of 5' adenosine monophosphate-activated protein kinase (ampk) and silent information regulator 1 (sirt1) which have potent role in antioxidant defence mechanism.Histopathological findings also showed hcr treatment prevented cardiac tissue from damage.Conclusion hcr treatment showed a significant cardioprotective effect in iso-induced cardiotoxicity in rats probably because of the potent antioxidant activity.Supplementary information the online version contains supplementary material available at .

Journal: Journal of diabetes and metabolic disorders (2022)
Publication types: Journal Article
B-Cell Epitope Mapping from Eight Antigens ofCandida albicansto Design a Novel Diagnostic Kit: An Immunoinformatics Approach.

Invasive candidiasis is an emerging fungal infection and a leading cause of morbidity in health care facilities.Despite advances in antifungal therapy, increased antifungal drug resistance in candida albicanshas enhanced patient fatality.The most common method for candida albicansdiagnosing is blood culture, which has low sensitivity.Therefore, there is an urgent need to establish a valid diagnostic method.Our study aimed to use the bioinformatics approach to design a diagnostic kit for detecting candida albicanswith high sensitivity and specificity.Eight antigenic proteins of candida albicans(hyr1, hwp1, ece1, als, eap1, sap1, bgl2, and met6) were selected.Next, a construct containing different immunodominant b-cell epitopes was derived from the antigens and connected using a suitable linker.Different properties of the final construct, such as physicochemical properties, were evaluated.Moreover, the designed construct underwent 3d modeling, reverse translation, and codon optimization.The results confirmed that the designed construct could identify candida albicanswith high sensitivity and specificity in serum samples of patients with invasive candidiasis.However, experimental studies are needed for final confirmation.Supplementary information the online version contains supplementary material available at .

Journal: International journal of peptide research and therapeutics (2022)
Publication types: Journal Article
Identification of Compounds Targeting HuD. Another Brick in the Wall of Neurodegenerative Disease Treatment.

Elav-like (elavl) rna-binding proteins play a pivotal role in post-transcriptional processes, and their dysregulation is involved in several pathologies.This work was focused on hu d (elavl4), which is specifically expressed in nervous tissues, and involved in differentiation and synaptic plasticity mechanisms.Hu d represents a new, albeit unexplored, candidate target for the treatment of several relevant neurodegenerative diseases.The aim of this pioneering work was the identification of new molecules able to recognize and bind hu d, thus interfering with its activity.We combined virtual screening, molecular dynamics (md), and std-nmr techniques.Starting from around 51 000 compounds, four promising hits eventually provided experimental evidence of their ability to bind hu d.Among the selected best hits, folic acid was found to be the most interesting one, being able to well recognize the hu d binding site.Our results provide a basis for the identification of new hu d interfering compounds which may be useful against neurodegenerative syndromes.

Journal: Journal of medicinal chemistry (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Association of Human Leucocyte Antigen Polymorphism with Coronavirus Disease 19 in Renal Transplant Recipients.

Human leucocyte antigens (hlas) are highly polymorphic glycoproteins expressed at the surface of all nucleated cells.It is required for the sars-co v-2 peptide antigen presentation to immune cells for their effector response.However, polymorphism in hla significantly impacts the binding of sars-co v-2 antigenic peptide to the hla pocket and regulates immune activation.In this study, 514 renal transplant recipients (rtrs) were recruited from the outpatient department and categorized either into symptomatic (n = 173) or asymptomatic groups (n = 341) based on coronavirus disease-19 (covid-19) symptoms.The anti-sars-co v-2 spike protein-specific ig g antibody titer was measured by chemiluminescent microparticle immune-assay methods in 310 rtrs.The hla details of 514 patients were retrieved from the electronic medical records and analyzed retrospectively.We found that hla antigen allele a*24 was significantly associated with asymptomatic infection in 22.78%, hla c*02 in 4.51%, drb1*12 in 10.85%, and hla dqa1*02 in 27.74% of rtrs.Whereas hla a*29 in 3.46%, a*33 in 26.01%, b*13 in 10.40%, drb1*10 in 4.62%, drb1*15 in 39.30%, drb1*30 in 1.15%, and dqa1*60 in 3.57% of rtrs were associated with symptomatic infection.Hla drb1*13 and drb1*15 were associated with moderate to severe degrees of covid-19 disease.The seroconversion rate in asymptomatic patients was 118/137 (86.13%), had a median titer of 647.80 au/ml, compared to symptomatic patients 148/173 (85.54%) with a median titer of 400.00 au/ml, which was not significant between the two groups (p= 0.88 and 0.13).In conclusion, hla alleles a*24, c*02, drb1*12, and dqa1*02 were significantly associated with asymptomatic infection, and a*29, a*33, b*13, drb1*10, drb*15, and drb1*30 were significantly associated with symptomatic infection.Hla drb1*13 and drb1*15 were associated with moderate to severe degrees of covid-19 disease.

Journal: Vaccines (2022)
Publication types: Journal Article
Sensory and metabolite migration from tilapia skin to soup during the boiling process: fast and then slow.

This study mainly studied sensory and metabolite migration from the skin to the soup in the boiling process of tilapia skin using content analysis, electronic nose technique, electronic tongue technique, and metabolomics technique based on ultra-high performance liquid chromatography-mass spectrometry/mass spectrometry and gas chromatography-time-of-flight-mass spectrometry.The content changes, flavor changes, taste changes, metabolite numbers and differential metabolite numbers for both tilapia skin and soup mainly occurred in the initial 30 min.Moreover, the initial 10 min was the key period for the metabolite changes in the boiling process.Further, the differential metabolites in these three periods (0-10, 10-30, and 30-60 min) were identified to show the metabolites migration process.Six (adenine, gingerol, terephthalic acid, vanillin, pentanenitrile, and 2-pyrrolidinonede) and seven (butyramide, lysope(0:0/20:4(5z,8z,11z,14z)), lysope(22:6(4z,7z,10z,13z,16z,19z)/0:0), linoleic acid, n-acetylneuraminic acid, l-threose, and benzoin) chemicals were screened out in the differential metabolites of tilapia skin and soup, respectively, with variable importance in the projection of >1 and p value of <0.05.This work would be beneficial to understand the sensory and metabolite migration in the preparation process of fish soup and provided a metabolomic analysis route to analyze metabolites migration in food.

Journal: NPJ science of food (2022)
Publication types: Journal Article
A new cardiac phantom for dynamic SPECT.

In recent years, with the advance of myocardial blood flow (mbf) measurement capability in dynamic single photon emission computerized tomography (spect) systems, significant effort has been devoted to validation of the new capability.Unfortunately, the mechanical phantoms available for the validation process lack essential features-they either have a constant radiotracer concentration or they have rigid (static) walls unable to simulate cardiac beating.Methods and results we have developed a mechanical cardiac phantom that is able to mimic physiological radiotracer variation in the left ventricle (lv) cavity and in the myocardium (m), while performing beating-like motion.We have also developed a mathematical model of the phantom, allowing a description of the radiotracer concentrations in both regions (lv, m) as a function of time, which served as a tool for experiment planning and to accurately mimic physiological-like time-activity curves (tacs).A net retention model for the phantom was also developed, which served to compute the theoretical (i.e., expected) mbf of the phantom from measured quantities only, and thus validate the mbf reported by the spect system.In this paper, phantom experiments were performed on a ge discovery nm 530c spect system.Conclusions a novel dynamic cardiac phantom for emission tomography has been developed.The new phantom is capable of producing a wide range of tacs that can mimic physiological (and potentially in the future, pathological) curves, similar to those observed in dynamic spect systems.Spect-reported mbf values were validated against known (measured) activity of the injected radiotracer from phantom experiments, which allowed to determine the accuracy of the ge discovery 530c spect system.

Journal: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (2021)
Publication types: Journal Article