syedzayyan/paper_mill_benchmark huggingface dataset:
Tranexamic Acid versus Epsilon-Aminocaproic Acid in Total Knee Arthroplasty: A Meta-Analysis

At present, the effect of tranexamic acid (txa) and epsilon-aminocaproic acid (eaca) on total knee arthroplasty (tka) remains controversial.Therefore, the aim of this meta-analysis is to compare the differences between the effects of txa and eaca in tka.Methods.We used electronic databases, including pub med, embase, medline, ovid, science direct, cochran library, google scholar, clinical trial, and chinese related databases, for literature search to find any effect of txa and eaca in tka.The differences between groups were compared by odds ratio (or), weighted mean difference (wmd), and 95% confidence interval (ci).A total of four studies, including 3 randomized controlled trials (rct) and 1 cohort study, were involved in this meta-analysis, involving 1836 participants.Among these participants, 816 belonged to the txa group and 1020 belonged to the eaca group.Results.Meta-analysis indicated no difference in surgery time (wmd = 0.01, 95% ci −0.35 to 0.36), total amount of blood loss (wmd = 0.14, 95% ci −0.09 to 0.37), transfusion rate (or = 0.74, 95% ci 0.20 to 2.78), transfusion units per patient (smd = −0.15, 95% ci −0.54 to 0.25), complications (or = 0.75, 95% ci 0.37 to 1.55), and length of stay (smd = −0.01, 95% ci −0.11 to 0.08).Conclusions.Our results suggest that the effect of txa is not superior to eaca in tka.However, this conclusion still needs to be further confirmed by multicenter and large-sample clinical trials.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Meta-Analysis;
The Way of Severe Nursing of Respiratory System Failure

Respiratory failure is the most common clinical symptom, seriously endangering people’s health, which is mainly caused by a series of reasons, leading to serious respiratory dysfunction and severe pulmonary respiratory disorders, damaging the pulmonary airway function, and causing disability to maintain normal human gas exchange activities.At present, the main treatment of respiratory failure is to use the ventilator to help patients exchange gas and keep their breathing unobstructed.The nursing method is also around the artificial airway mechanical ventilation.The nursing of patients with respiratory failure is mainly respiratory nursing and psychological nursing.In this paper, the main research is to explore the way of severe nursing of respiratory failure.Before the nursing of respiratory failure, we should carry out nursing detection of the ventilator and test its performance, tightness, pipeline safety, and airway patency.Then carrying on the respiratory failure mechanical ventilation nursing and clarifying its mechanical ventilation nursing process is the main work of intensive care, at the same time, giving consideration to the psychological nursing of respiratory failure and implementing comprehensive nursing.In this paper, 50 patients were selected and divided into group a and group b; group a was given comprehensive nursing, and group b was given general nursing.The experimental results show that a series of situations in group a are more optimistic than those in group b.There was no doubt that the ph value of the two groups changed significantly 6 months after discharge.The p o2 value of group a was higher than that before discharge, while the p co2 value of group b was unstable and increased.The p o2 value of group a was 55.52 before discharge and 62.36 six months after discharge.The p co2 value of group a was 54.31 before discharge and 50.61 six months after discharge.The p co2 value of group b was 55.23 before discharge and 57.34 six months after discharge.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
The Value of Echocardiography Combined with NT-pro BNP Level in Assessment and Prognosis of Diastolic Heart Failure

To investigate the significance of echocardiography combined with n-terminal pro-b-type natriuretic peptide (nt-pro bnp) levels in the evaluation and prognosis of diastolic heart failure (dhf).Methods.Clinical data were collected from 168 patients with dhf.Serum levels of nt-pro bnp were first measured by elisa.Meanwhile, the echocardiography was used to examine left ventricular end-diastolic diameter (lvedd), left ventricular diameter (lvd), and other parameters.Multivariate logistic regression analysis was performed for variables in heart failure assessment grade or poor prognosis.Finally, the predictive ability for new york heart association (nyha) class as well as prognosis was assessed by roc curves.Results.Nt-pro bnp was the overexpression in the serum of patients with dhf.And the degree of elevation was related to nyha class, while nt-pro bnp levels were significantly higher in the p-mace group than in the n-mace group.According to the multivariate logistic regression analysis, the ratio of peak velocity of left atrial early diastolic blood flow to early diastolic peak velocity of mitral annulus ( e /ea) and serum nt-pro bnp level was risk factors for nyha class and prognosis.However, lvef, lvedd, and flow propagation velocity (vp) can be a benefit condition.In addition, roc curve showed that echocardiography combined with nt-pro bnp content had higher accuracy in nyha class and prognostic assessment of dhf than applied separately.Conclusions.The diagnosis of echocardiography combined with nt-pro bnp levels has the potential to distinguish the nyha class in heart function of patients with dhf and determine the prognosis of patients.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
The Understanding of Medical Informatics among Dental and Medical Students

Current medical care deeply relies on informatics during all stages of patient care, which is significantly enhanced due to its use.The healthcare professional’s formation in medical informatics results crucial for their everyday practice.However, healthcare study programs not always provide education about the use of this wide variety of systems, and young professionals find that they need to learn about it over the experience.The aim of this study was to assess the understanding of medical and dental students regarding medical informatics and icts.Materials and methods .A questionnaire was produced with 3 sections and a total of 24 questions.Students replied to the survey before and after taking the medical informatics course.Results .A total of 719 students from second year of medical and dental school were recruited for the study between the period of september of 2017‐may 2018, september 2018‐may 2019, september 2019‐may 2020, and september 2020‐may 2021.Medical and dental students showed a good level of understanding regarding medical informatics, as well as a good perception of the relevance of ict learning for the professional practice.Course attendance increased the percentage of students that felt confident of their knowledge about medical informatics.However, most students felt that little or no medical informatics education was lectured at their schools and that the university should adapt the academic program to include it.After taking the course, the student’s perception on this matter was improved.Conclusion .Medical and dental students find medical informatics learning useful for their future professional practice and feel inclined to use it.However, they feel that universities need to adapt their programs in order to include medical education courses and trainings; partly because they are not completely aware of the use of icts that already are established in their courses.

Journal: BioMed Research International (2022)
Publication types: Research Article;
The Teaching Method of Basketball Training Based on Intelligent Network Multimedia Technology

In the traditional sports basketball teaching, people gradually find that the simple use of body language and oral language as the carrier of teaching sports skills and theoretical knowledge has certain limitations.Therefore, we begin to focus on the combination of network multimedia technology (nmt) and basketball training teaching (btt).This article mainly studies the teaching method of basketball training based on nmt.This article expounds the concept and function of multimedia teaching, puts forward suggestions on btt methods based on nmt, and studies the making method of multimedia basketball training (mbt) courseware.Through the questionnaire survey and experimental research, this article analyzes the influence of mbt on basketball teaching, the effectiveness of multimedia basketball students’ mastery, the evaluation results of mbt, and the evaluation of experimental group students on mbt.In this study, 100 students were selected as the experimental objects, a group of 50 people for the basic basketball action test, one group had a period of multimedia basketball teaching, and the other group still carried on according to the traditional basketball teaching method.The results show that in the experiment of mbt, the total proportion of the experimental group is 56.61% and the control group is 33.72%; the experimental group is 57.28% and the control group is 42.35%; the experimental group is 63.26% and the control group is 32.79%; and the experimental group is 70.56% and 37% in the control group.

Journal: Mobile Information Systems (2021)
Publication types: Research Article;
The Relevance of Interventional Time and Clinical Outcomes in Patients with NSTEMI Based on the GRACE Score

To investigate the relevance between interventional time and clinical outcomes in non-st-elevation myocardial infarction (nstemi) patients of different risk stratifications, which were divided into different groups according to grace scores and the time from admission to percutaneous coronary intervention (pci).Method.Patients were grouped according to the grace score and the time from admission to intervention therapy.The cox multivariate risk regression model was used to analyze the correlation between the grace score and the time from admission to intervention therapy with major adverse cardiovascular events (maces).Cox interactive item regression was also used to investigate the correlation between the time of intervention therapy and grace risk stratification with clinical outcomes and to evaluate the efficacy of intervention therapy in different risk stratifications of patients with nstemi.Results.Interactive item cox regression analysis and subgroup analysis show that high-risk nstemi patients with a grace score &gt; 140 points and the time from admission to intervention &lt; 24 h ( p = 0.0004 ) and 24–72 h ( p = 0.0143 ) have interactive effects on the impact of the mace event with the reference of intervention time &gt; 72 h and grace score &lt; 108 points.The time from admission to intervention &lt; 24 h is an independent protective factor for the occurrence of mace events ( hr = 0.166 , 95% ci 0.052-0.532, p = 0.0025 ).Middle-risk patients with nstemi with a grace score of 109–140 points and the time from admission to intervention &lt; 24 h ( p = 0.0370 ) and 24–72 h ( p = 0.0471 ) have an interactive effect on the impact of mace.The time from admission to intervention &gt; 72 h is an independent protective factor for the occurrence of mace ( hr = 0.201 , 95% ci 0.045-0.897, p = 0.0355 ).Conclusion.The time from admission to intervention &lt; 24 h could effectively reduce the risk of mace events within 1 year in high-risk patients with nstemi (grace score &gt; 140 points); the time from admission to intervention &gt; 72 h can reduce the risk of mace events within 1 year in low-risk patients with nstemi (grace score ≤ 108 points).

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
The Protective Effect of Interval Exercise on Myocardial Ischemia-Reperfusion Injury in Players

In recent years, the popularity of sports has been increasing.In the high‐intensity competition, many players have been injured; most of them are myocardial ischemia.With the development of medical science and technology, myocardial ischemia can be reperfusion.However, sometimes, the function of tissues and organs cannot be restored, but the dysfunction and structural damage of tissues and organs can be aggravated.Therefore, it is necessary to actively carry out intermittent exercise to protect players from myocardial ischemia‐reperfusion injury.The purpose of this paper is to explore the protective effect of intermittent exercise on the myocardial ischemia‐reperfusion injury of players.60 clean male sprague dawley (sd) old rats were selected as the research objects, which were divided into control group, ischemia/reperfusion model group, intermittent exercise + model group, and intermittent exercise + control group, and compared the parameters of heart function indexes of each group.The results showed that the creatine kinase (ck) content of control group was 0.577 ± 0.176 u/ml, lactate dehydrogenase (ldh) content was 7.834 ± 1.507 u/ml, model group was 1.257 ± 0.113 u/ml, lactate dehydrogenase (ldh) content was 14.441 ± 1.793 u/ml, intermittent exercise + model group was 0.987 ± 0.127 u/ml, lactate dehydrogenase (ldh) content was 11.714 ± 3.017 u/ml, intermittent exercise + control group was 1.103 ± 0.125 u/ml, and lactate dehydrogenase (ldh) content was 14.647 ± 2.575 u/ml.It can be seen that intermittent exercise has a good protective effect on myocardial ischemia‐reperfusion injury.If the interval exercise method is integrated into the daily training of athletes, it can effectively improve the perfusion injury caused by myocardial ischemia.

Journal: BioMed Research International (2022)
Publication types: Research Article;
The Neuroprotective Effect of miR-136 on Pilocarpine-Induced Temporal Lobe Epilepsy Rats by Inhibiting Wnt/β-Catenin Signaling Pathway

To explore the effect of mi r-136 on temporal lobe epilepsy (ep) and its mechanism of action.Methods.30 male rats were injected intraperitoneally with 30 mg/kg pilocarpine to construct a rat temporal lobe epilepsy model, and they were randomly divided into 5 groups ( n = 6 per group): control group, ep group, agomir nc group, mi r-136 agomir group, and mi r-136+li cl group.The brain tissues of the rats were collected 7 days after the treatment.The expression of mi r-136 in the hippocampus tissue was detected by q rt-pcr.H&amp;e and nissl staining were used to observe the histopathological changes and neuron damage in the hippocampus tissue.Il-1β, il-6, and tnf-α levels in the hippocampus tissue were detected by elisa.Flow cytometry was used to detect the apoptosis rate in the hippocampus tissue.Western blot was used to detect the expression levels of c-caspase-3, bcl-2, β-catenin, cyclin d1, and c-myc protein in the hippocampus.Results.The expression of mi r-136 was significantly downregulated in the hippocampus tissue of epileptic rats.After overexpression of mi r-136, the number of seizures and the duration of epilepsy in rats were significantly reduced.At the same time, hippocampal tissue damage was improved considerably, and the degree of neuronal damage decreased.Overexpression of mi r-136 also significantly reduced the apoptosis rate in the hippocampus tissue and inhibited the levels of inflammatory factors.Meanwhile, mi r-136 downregulates the expression of wnt/β-catenin signaling pathway-related proteins.However, wnt pathway activator li cl could destroy the protective effect of mi r-136.Conclusion.Mi r-136 could exert its neuroprotective influence on temporal lobe epilepsy rats by inhibiting the wnt/β-catenin signaling pathway.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
The N6-Methyladenosine- (m6A-) Associated Genes Act as Strong Key Biomarkers for the Prognosis of Pancreatic Adenocarcinoma

Pancreatic adenocarcinoma (paad) has become the major cause of cancer-related deaths globally.The m6a (n6-methyladenosine) alteration plays a crucial function in carcinogenesis and tumor progression.The role of genes related to m6a and their expression level in pancreatic cancer is not identified yet.The objective of this research analysis is a demonstration of the m6a rna methylation regulators based as biomarkers for the paad diagnosis.Methods.About 23 extensively reported m6a rna methylation regulators were identified through the cancer genome atlas (tcga) database.This identification was based on consensus clustering analysis, protein-protein integration (ppi) analysis, risk prognostic model, cox-regression analysis, string spearman analysis, and lasso cox-regression.Results.Herein, we conclude that 23 m6a methylation regulators have a strong link with the clinical and molecular characteristics of paad.The three subgroups (1/2) of pancreatic adenocarcinoma were identified using the clustering of 23 m6a regulators.Subgroup cluster 2 had a lower survival rate than the subgroup of cluster 1, and the difference in grades between the two groups was substantial.An assessment was performed using the 23 reported m6a methylation regulators.Eight of these can be used as independent paad prognostic markers.The consequences of variable igf2bp3 expression in paad were then investigated further.Conclusions.The key finding of this study was that the m6a methylation regulator gene has the main role in pancreatic tumors, and it may be used as a biomarker in the prognosis of the paad and for therapy purposes.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
The Mechanism of Osthole in the Treatment of Gastric Cancer Based on Network Pharmacology and Molecular Docking Technology

To study the mechanism of osthole in gc based on network pharmacology and molecular docking.Methods.The potential targets of osthole were predicted through the tcm system pharmacology analysis platform, swiss target prediction, and pharm mapper database.Targets related to gastric cancer were obtained through omim and gene card database.The online tool venny 2.1.0 was used to screen gc and common target of osthole.The targets after the intersection of drugs and diseases were entered into the string database, and the protein interaction network was constructed, and the core targets with high correlation were screened out.The web gestalt website was used to go functional enrichment and kegg pathway analysis and visualization with kobas website.The cytoscape 3.8.2 was employed to draw the c-t-p-d (compound–target–pathway–disease) network visualization diagram.Finally, molecular docking validation was performed using py mol 2.5 and discovery studio standalone.Results.Through prediction and screening, 108 corresponding targets were screened from osthole, and 173 targets were obtained after intersecting with gastric cancer targets.Among them, the top ten targets were the core targets of this study, including mapk3, mapk1, src, akt1, hsp90aa1, rxra, esr1, rela, mapk14, and egfr.The analysis of go, kegg, and ppi showed that the mechanism of action of osthole against gc may be closely related to the regulation of the pi3k signaling pathway.The results of molecular docking showed that osthole had a good affinity with mapk3, which is a crucial part of the pi3k signaling pathway.Conclusion.This study preliminarily revealed the targets and related pathways of osthole in the treatment of gastric cancer and provided a new idea for further exploration of osthole targeted prevention and treatment of gastric cancer.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
The Imaging Diagnosis of Patients with Shoulder Pain Caused by Sports Injury

The shoulder joint is the most complex and movable joint of the human body.A variety of diseases can affect the shoulder joint and cause shoulder pain.Sports injuries are an important and common cause of shoulder pain.In the clinical diagnosis of shoulder joint injury, the most commonly used diagnostic methods are x-ray photography and ct imaging, but x-ray photography has poor ability to distinguish shoulder joints and other tiny tissue structures and has a sense of inspiration for shoulder joint injuries.In addition, ct arthrography has a certain risk to the lesion and is easy to form trauma, and it cannot clearly show the shoulder joint structures such as the rotator cuff and the labrum.Therefore, this article conducts mr imaging diagnostic research on patients with shoulder pain caused by sports injuries and plays an important role in imaging.This article deeply studied the clinical manifestations of shoulder joint pain and image processing technology, designed a research experiment on imaging diagnosis results of patients with shoulder joint pain caused by sports injuries, selected 87 patients with shoulder joint pain in a hospital, and analyzed x-ray photography, ct imaging, and mr imaging diagnosis, three methods to compare the diagnostic accuracy and inspection results and conduct an in-depth analysis of the causes of shoulder joint injury.The experimental results showed that there were 87 patients with shoulder joint pain, 65 patients with rotator cuff tear were diagnosed using arthroscopy, and 63 patients with rotator cuff tear were diagnosed by mr imaging.The accuracy rate was as high as 95.6%.Among them, the proportion caused by sports injuries is the highest, reaching 56%.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
The Efficacy and Safety of Anlotinib Alone and in Combination with Other Drugs in Advanced Lung Cancer: A Retrospective Cohort Study

Lung cancer is a disease associated with high levels of morbidity and mortality, with approximately 2.1 million new cases every year.Anlotinib is a new small-molecule multitarget tyrosine kinase inhibitor independently developed in china that can inhibit the formation of tumor blood vessels and has a therapeutic effect on various cancers.However, the application of anlotinib in lung cancer needs further investigation.Methods.We collected the progress notes of 43 patients with advanced lung cancer treated at the oncology department of guangzhou chest hospital from march 2019 to march 2021.Additionally, we assessed the differences between drug combination therapy and single-drug therapy among patients treated with anlotinib.Results.Patients in both the anlotinib-combination and anlotinib-monotherapy groups experienced remission; however, the overall disease control rate in the anlotinib-combination group was higher than that in the anlotinib-monotherapy group.Reexamination via computed tomography showed that patients in the anlotinib-combination group had better recovery than those in the anlotinib-monotherapy group.Although the overall incidence of adverse reactions in the anlotinib-combination group was higher than that in the monotherapy group, most of the adverse reactions were i–ii levels and improved after symptomatic treatment.Conclusion.Anlotinib combined with other therapies is better than anlotinib alone for the management of patients with advanced lung cancer.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;