syedzayyan/paper_mill_benchmark huggingface dataset:
AGREEing on Clinical Practice Guidelines for Autism Spectrum Disorders in Children: A Systematic Review and Quality Assessment.

Autism spectrum disorder (asd) is a multifaceted neurodevelopmental disorder requiring multimodal intervention and an army of multidisciplinary teams for a proper rehabilitation plan.Accordingly, multiple practice guidelines have been published for different disciplines.However, systematic evidence to detect and intervene must be updated regularly.Our main objective is to compare and summarize the recommendations made in the clinical practice guidelines (cpgs) for asd in children released from november 2015 to march 2022.Methods cpgs were subjected to a systematic review.We developed the inclusion and exclusion criteria and health-related questions, then searched and screened for cpgs utilizing bibliographic and cpg databases.Each of the cpgs used in the study were critically evaluated using the appraisal of guidelines for research and evaluation ii (agree ii) instrument.In a realistic comparison table, we summarized the recommendations.Results four eligible cpgs were appraised: australian autism crc (acrc); ministry of health new zealand (nz); national institute for health and care excellence (nice); and scottish intercollegiate guidelines network, healthcare improvement scotland (sign-his).The overall assessments of all four cpgs scored greater than 80%; these findings were consistent with the high scores in the six domains of agree ii, including: (1) scope and purpose, (2) stakeholder involvement, (3) rigor of development, (4) clarity of presentation, (5) applicability, and (6) editorial independence domains.Domain (3) scored 84%, 93%, 86%, and 85%; domain (5) 92%, 89%, 54%, and 85%; and domain (6) 92%, 96%, 88%, and 92% for acrc, nice, nz, and sign-his, respectively.Overall, there were no serious conflicts between the clinical recommendations of the four cpgs, but some were more comprehensive and elaborative than others.Conclusions all four assessed evidence-based cpgs demonstrated high methodological quality and relevance for use in practice.

Journal: Children (Basel, Switzerland) (2022)
Publication types: Journal Article;Review
Molecular dynamics simulation, synthesis and topoisomerase inhibitory actions of vanillin derivatives: a systematic computational structural integument.

A series of 4-hydroxy-3-methoxy benzaldehyde (vanillin) derivatives (3a-3r) was designed for the principle of schiff base condensation with several individual sulfanilamide analogues.The inhibitory potencies of the designed compounds were evaluated through molecular docking simulation studies against the targets, breast cancer-topo isomerase-iiα and estrogen receptor-α; and the top scoring poses with higher binding energy were selected to assess the mode of binding and stability of each complex through molecular dynamics simulations.Compounds that remained stable in the active sites of the both target receptors through a number of strong h-bonds and hydrophobic contacts were selected.Based on the computational results, these selected compounds,3b, 3eand3fwere synthesized and were followed up for structural elucidation attempts, by ft/atr,1h nmr and13c nmr.From the experimentalin vitrostudies on3b, 3e and 3f,the following remarkable activities against breast cancer cell line were done; ic50values of3b, 3eand3fwere noted, 6.7, 4.3 and 11 ng/m l, respectively.These newly synthesized compounds may be used as novel inhibitors of nuclear receptors with potential therapeutic applications in control of cancer.communicated by ramaswamy h.Sarma.

Journal: Journal of biomolecular structure & dynamics (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Positive experiences of family caregivers of patients with chronic heart failure: protocol for a qualitative systematic review and meta-synthesis.

Introduction previous studies have highlighted the experiences of caregivers for patients with chronic heart failure (chf), specifically focusing on their negative experiences.There are few systematic reviews on the topic to synthesise the positive experiences of family caregivers for patients with chf.This study will examine how experiences such as developing new skills, strengthening their relationships (between caregivers and recipients) and receiving appreciation from the care recipient assist to improve caregivers' perception of their circumstances.Methods and analysis this review will be conducted in accordance with the joanna briggs institute (jbi) methodology for qualitative systematic reviews.Qualitative and mixed methods studies related to the positive experiences of family caregivers for patients with chf, reported in english or chinese and published from inception in the following databases will be included: pub med, medline, embase, cochrane library, web of science, psyc info, cinahl, wan fang data, china national knowledge infrastructure, chongqing vip, chinese biomedical literature database, open grey and deep blue library databases.The standard jbi critical appraisal checklist for qualitative research will be used by two independent reviewers to appraise the quality of the included studies, and the standardised jbi qualitative data extraction tool for qualitative research will be applied to extract data.The final synthesised findings will be graded according to the con qual approach for establishing confidence in the output of qualitative research synthesis.Ethics and dissemination ethical approval is not required as no primary data are being collected.The results will be made available through a peer-reviewed publication.Prospero registration number crd42021282159.

Journal: BMJ open (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Ultrathin Two-Dimensional Bimetal-Organic Framework Nanosheets as High-Performance Electrocatalysts for Benzyl Alcohol Oxidation.

Ultrathin two-dimensional metal-organic frameworks (2d mofs) have the potential to improve the oxidation of benzyl alcohol (ba) with a large surface area and open catalytic active sites.To achieve high-efficiency electrocatalysts for the oxidation of benzyl alcohol, a moderate solvothermal method was evolved to synthesize a series of 2d mofs on nickel foam (ni-mof/nf, ni co-61-mof/nf, ni co-21-mof/nf).As the electrocatalyst used for the oxidation of benzyl alcohol, ni co-61-mof/nf presented a lower overpotential and superior chemical durability than other electrocatalysts; it only required a potential of ∼1.52 v (vs rhe) to reach 338.16 m a cm-2, with an oxidation efficiency of more than 86%.Besides, after continuous electrocatalysis for 20 000 s at 1.42 v (vs rhe), the current density of ni co-61-mof/nf nanosheets was still 38.67 m a cm-2with 77.34% retention.This demonstrated that ni co-61-mof/nf nanosheet electrocatalysts had great potential for benzyl alcohol oxidation.From both the experimental and theoretical studies, it was discovered that ni co-61-mof/nf nanosheets have the highest electrocatalytic activity due to their distinctive ultrathin 2d structure, optimized electron structure, and more accessible active sites.This finding would pave a brand-new thought for the design of electrocatalysts with electrocatalytic activity for benzyl alcohol oxidation (ebo).

Journal: Inorganic chemistry (2022)
Publication types: Journal Article
Postinterventional antithrombotic management after venous stenting of the iliofemoral tract in acute and chronic thrombosis: A systematic review.

Venous stenting has become a common treatment option for central deep venous outflow obstructions and postthrombotic syndrome.Following successful recanalization and stenting, stent patency is endangered by in-stent thrombosis and recurrent venous thromboembolism.Antithrombotic therapy might reduce patency loss.This systematic review summarizes the literature on antithrombotic therapy following (post)thrombotic venous stenting.A systematic pub med, medline, embase, and cochrane search was performed for studies addressing antithrombotic therapy prescribed following venous stenting of the iliofemoral tract indicated by acute or chronic thrombotic pathology.A total of 277 articles was identified of which 64 (56 original studies) were selected.Overall, a mean primary patency rate of 82.3% was seen 1 year after the intervention, which decreased to 73.3% after 2 years.In the majority (43 of 56 studies, 77%), treatment was based on use of vitamin k antagonists, either with (18%) or without (59%) use of antiplatelet drugs.Only two studies (4%) directly assessed the effect of antithrombotic therapy on treatment outcomes.The impact of postinterventional antithrombotic therapy on stent patency remains unknown because of limited and insufficient data available in current literature.Further clinical research should more clearly address the role of antithrombotic therapy for preservation of long-term patency following venous stenting.

Journal: Journal of thrombosis and haemostasis : JTH (2021)
Publication types: Journal Article;Systematic Review
Knowledge and Attitude of Iranian University Students toward Genital Warts.

Human papillomavirus (hpv) is one of the well-known causes of cervical cancer and one of the most prevalent sexually transmitted diseases (stds).Since cervical cancer is one of the most common causes of morbidity and mortality in women, this study was performed to investigate iranian medical students' knowledge and attitudes towards genital warts.This cross-sectional study assessed the perception and attitudes of 385 students at babol university of medical sciences using a preconceived questionnaire.The participants' mean age was 23.70 ± 3.27 years, with a range of 20-50 years.Evaluation of these students' level of general information about hpv showed that 7 (1.8%) students had inadequate general information, 34 (8.8%) had moderate knowledge, and 344 (89.4%) had good general knowledge in this regard.There was also a significant association between students' general knowledge of hpv and their field of study.Based on our results, the knowledge of the majority of babol university of medical sciences students about genital warts was in a good range, and their knowledge about hpv routes of transmission was of moderate level.Moreover, the majority had an appropriate attitude to interact with people infected with hpv.

Journal: Interdisciplinary perspectives on infectious diseases (2022)
Publication types: Journal Article
Effect of host and environment-related factors on fleas of the pichi, an armadillo from Argentina.

The pichi (zaedyus pichiy; cingulata: chlamyphoridae) is an armadillo whose ectoparasite fauna is composed of ticks and fleas.Fleas were collected from 218 pichis in southern mendoza, argentina, in summer and winter of 2015 and 2016.Prevalences were analyzed and differences in the intensities of the total number of fleas related to host (age, sex, weight, size and physical condition) and environment-related (seasonality and year) factors evaluated.Phthiropsylla agenoris was the only species found.Intensities of fleas were higher in 2015, in juveniles, and in males.Individuals with poor physical condition were more parasitized than those with good or normal body condition.The main explanatory variable was sampling year.This factor was directly associated with precipitation.The extreme conditions and heavy rains during the el niño event in 2015/2016 led to environmental changes that seem to have severely affected the life cycle of fleas.

Journal: Anais da Academia Brasileira de Ciencias (2020)
Publication types: Journal Article
Costs of health and social services use in children of parents with mental illness.

Children of parents with mental illness have a higher risk of developing mental health problems when compared with the general population.Therefore, families with parents with mental illness are a suitable target group for selective prevention.In order to plan and evaluate the health economic consequences of preventive interventions for this target group, data on the societal costs related to parenthood under the condition of mental disorders are needed.To date, within germany there has been a lack of research evaluating the costs of mental health treatment and use of social services by children and adolescents with parents with mental illness.Methods as part of a multicentre randomised controlled trial, use and costs of health and social services were assessed for a sample of 332 children and adolescents with parents with mental illness in six regions of germany.Service use at baseline was assessed by the german version of the children and adolescent mental health service receipt inventory.Costs were calculated for 12 months based on diagnosis and service user status and described separately.Cost drivers were identified by means of a two-part regression model.Results total mean costs for 12 months for the total sample amount of € 3736.35 (95% ci: € 2816.84-4813.83) per person.Children with a psychiatric diagnosis generated a total of € 5691.93 (95% ci: € 4146.27-7451.38) of costs per person, compared to € 1245.01 (95% ci: € 657.44-1871.49) for children without a psychiatric diagnosis.The logit part indicates significant odds ratios for individual functioning and diagnosis of the child as well as for family functioning.The linear part reveals that increasing individual functioning in the child is related to decreasing costs.Conclusions children of families with parents with mental illness use a broad spectrum of mental health care, school-based support and youth welfare services even if they are not yet diagnosed as having a mental disorder.Further research should examine whether these institutions are sufficiently qualified and interlinked to meet the support needs of this vulnerable group.Trial registration the study was registered at the 07/10/2014 before the start of data collection (04/11/2014) at the german clinical trials register (deutsches register klinischer studien, drks, nr: drks00006806, id=trial.html&trial_id=drks00006806 ).

Journal: Child and adolescent psychiatry and mental health (2021)
Publication types: Journal Article
Dual-network polyacrylamide/carboxymethyl chitosan-grafted-polyaniline conductive hydrogels for wearable strain sensors.

Conductive, wearable, and flexible hydrogel-based sensors are considered as promising applications in human motion detection and physiological signal monitoring.However, it is still a problem to integrate multiple functions into one material for the next-generation smart devices.Herein, we fabricated an ionic/electronic dual conductive hydrogel by combining the chemically crosslinked polyacrylamide (pam) and the physically crosslinked carboxymethyl chitosan-grafted-polyaniline (cmcs-g-pani)/ag+network.The double-network hydrogel displays a high stretchability, repeatable adhesiveness, antibacterial activities, and biocompatibility.It also has high sensitivity and stable electrical performance for wearable strain sensors.Furthermore, we assembled a self-powered strain sensor based on the conversion of chemical energy to electrical energy.It can be used for human motion detection even without external power supply.This work provides an avenue for the development of multifunctional hydrogels with outstanding mechanical and electronic performances for application in wearable electronic devices.

Journal: Carbohydrate polymers (2022)
Publication types: Journal Article
Targeted delivery of a vaccine protein to Langerhans cells in the human skin via the C-type lectin receptor Langerin.

Human skin is a preferred vaccination site as it harbors multiple dendritic cell (dc) subsets, which display distinct c-type lectin receptors (clr) that recognize pathogens.Antigens can be delivered to clr by antibodies or ligands to boost antigen-specific immune responses.This concept has been established in mouse models but detailed insights into the functional consequences of antigen delivery to human skin dc in situ are sparse.In this study, we cloned and produced an anti-human langerin antibody conjugated to the ebv nuclear antigen 1 (ebna1).We confirmed specific binding of anti-langerin-ebna1 to langerhans cells (lc).This novel lc-based vaccine was then compared to an existing anti-dec-205-ebna1 fusion protein by loading lc in epidermal cell suspensions before coculturing them with autologous t cells.After restimulation with ebna1-peptides, we detected elevated levels of ifn-γ- and tnf-α-positive cd4+t cells with both vaccines.When we injected the fusion proteins intradermally into human skin explants, emigrated skin dc targeted via dec-205-induced cytokine production by t cells, whereas the langerin-based vaccine failed to do so.In summary, we demonstrate that antibody-targeting approaches via the skin are promising vaccination strategies, however, further optimizations of vaccines are required to induce potent immune responses.

Journal: European journal of immunology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Persistence Infection of TGEV PromotesEnterococcus faecalisInfection on IPEC-J2 Cells.

Transmissible gastroenteritis virus (tgev) is a coronavirus causing diarrhea with high incidence in swine herds.Its persistent infection might lead to epithelial-mesenchymal transition (emt) of swine intestinal epithelial cells, followed by subsequent infections of other pathogens.enterococcus faecalis(e.Faecalis) is a member of the enteric microorganisms and an opportunistic pathogen.There is no report of secondary e.Faecalisinfection to tgev, even though they both target to the intestinal tracts.To investigate the interactions between tgev and e.Faecalis, we set up an in vitro infection model by the swine ipec-j2 cells.Dynamic changes of cell traits, including emt and cell motility, were evaluated through q pcr, western blot, electronic microscopy, scratch test, transwell migration test and invasion test, respectively.The adhesion and invasion tests of e.Faecaliswere taken to verify the impact of the preceding tgev infection.The cell morphology and molecular marker evaluation results showed that the tgev persistent infection induced emt on ipec-j2 cells; increased cellular motility and invasion potential were also observed.Spontaneously, the expression levels of fibronectin (fn) and the membrane protein integrin-α5, which are dominant bacterial receptors on ipec-j2 cells, were upgraded.It indicated that the bacteria e.Faecalisadhered to ipec-j2 cells through the fn receptor, and then invaded the cells by binding with the integrin-α5, suggesting that both molecules were critical for the adhesion and invasion of e.Faecalisto ipec-j2 cells.Additionally, it appeared that e.Faecalisalone might trigger certain emt phenomena, implying a vicious circle might occur.Generally, bacterial and viral co-infections are frustrating yet common in both human and veterinary medicines, and our observations on enteric tgev and e.Faecalisinteractions, especially the diversity of bacterial invasion strategies, might provide new insights into the mechanisms of e.Faecalispathogenicity.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article
Multi-material 3D printing of programmable and stretchable oromucosal patches for delivery of saquinavir.

Oromucosal patches for drug delivery allow fast onset of action and ability to circumvent hepatic first pass metabolism of drugs.While conventional fabrication methods such as solvent casting or hot melt extrusion are ideal for scalable production of low-cost delivery patches, these methods chiefly allow for simple, homogenous patch designs.As alternative, a multi-material direct-ink-write 3d printing for rapid fabrication of complex oromucosal patches with unique design features was demonstrated in the present study.Specifically, three print-materials: an acidic saquinavir-loaded hydroxypropyl methylcellulose ink, an alkaline effervescent sodium carbonate-loaded ink, and a methyl cellulose backing material were combined in various designs.The co2content and p h of the microenvironment were controlled by adjusting the number of alkaline layers in the patch.Additionally, the rigid and brittle patches were converted to compliant and stretchable patches by implementing mesh-like designs.Our results illustrate how 3d printing can be used for rapid design and fabrication of multifunctional or customized oromucosal patches with tailored dosages and changed drug permeation.

Journal: International journal of pharmaceutics (2021)
Publication types: Journal Article
Distributed Blockchain-Based Platform for Unmanned Aerial Vehicles.

Internet of things (io t)-inspired drone environment is having a greater influence on daily lives in the form of drone-based smart electricity monitoring, traffic routing, and personal healthcare.However, communication between drones and ground control systems must be protected to avoid potential vulnerabilities and improve coordination among scattered uavs in the io t context.In the current paper, a distributed uav scheme is proposed that uses blockchain technology and a network topology similar to the io t and cloud server to secure communications during data collection and transmission and reduce the likelihood of attack by maliciously manipulated uavs.As an alternative to relying on a traditional blockchain approach, a unique, safe, and lightweight blockchain architecture is proposed that reduces computing and storage requirements while keeping privacy and security advantages.In addition, a unique reputation-based consensus protocol is built to assure the dependability of the decentralized network.Numerous types of transactions are established to characterize diverse data access.To validate the presented blockchain-based distributed system, performance evaluations are conducted to estimate the statistical effectiveness in the form of temporal delay, packet flow efficacy, precision, specificity, sensitivity, and security efficiency.

Journal: Computational intelligence and neuroscience (2022)
Publication types: Journal Article
The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon.

The cullin-ring ligase 4 e3 ubiquitin ligase component cereblon (crbn) is a well-established target for a class of small molecules termed immunomodulatory drugs (imi ds).These drugs drive crbn to modulate the degradation of a number of neosubstrates required for the growth of multiple cancers.Whereas the mechanism underlying the activation of crbn by imi ds is well described, the normal physiological regulation of crbn is poorly understood.We recently showed that crbn is activated following exposure to wnt ligands and subsequently mediates the degradation of a subset of physiological substrates.Among the wnt-dependent substrates of crbn is casein kinase 1α (ck1α), a known negative regulator of wnt signaling.Wnt-mediated degradation of ck1α occurs via its association with crbn at a known imi d binding pocket.Herein, we demonstrate that a small-molecule ck1α agonist, pyrvinium, directly prevents the wnt-dependent interaction of crbn with ck1α, attenuating the consequent ck1α degradation.We further show that pyrvinium disrupts the ability of crbn to interact with ck1α at the imi d binding pocket within the crbn-ck1α complex.Of note, this function of pyrvinium is independent of its previously reported ability to enhance ck1α kinase activity.Furthermore, we also demonstrate that pyrvinium attenuates crbn-induced wnt pathway activation in vivo.Collectively, these results reveal a novel dual mechanism through which pyrvinium inhibits wnt signaling by both attenuating the crbn-mediated destabilization of ck1α and activating ck1α kinase activity.

Journal: The Journal of biological chemistry (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural