syedzayyan/paper_mill_benchmark huggingface dataset:
Effect of Dapagliflozin on Clinical Outcome after Drug-Eluting Stent Implantation in Elderly T2DM Patients: A Real-World Study

To investigate the effect of dapagliflozin therapy on the clinical outcome of drug‐eluting stent (des) implantation in elderly patients with type 2 diabetes mellitus (t2dm).Methods .We retrospectively studied the real‐world data of patients with coronary heart disease who received des implantation in our hospital from may 2019 to may 2021.Baseline general data and laboratory results of patients were collected.All patients were followed up for two years after pci, and the follow‐up endpoints included in‐stent restenosis, major adverse cardiovascular events (mace), revascularization, rehospitalization, and all‐cause mortality.Results .Compared with those before treatment, body mass index, systolic blood pressure, diastolic blood pressure, tg, tc, ldl‐c, fbg, and hb a1c were decreased in both groups after treatment, while hdl‐c was increased after treatment ( p &lt; 0.05).There were significant differences in bmi, systolic blood pressure, diastolic blood pressure, fbg, and hb a1c between the two groups before and after treatment.At the end of follow‐up, the incidence of in‐stent restenosis and mace in the dapagliflozin group was lower than that in the nondapagliflozin group.K‐m curve analysis showed a significant difference in in‐stent restenosis and mace after des implantation between the dapagliflozin group and the nondapagliflozin group (logrank χ 2 = 5.093, 4.524; p = 0.024, 0.033).Conclusion .In accurate clinical data, dapagliflozin could significantly improve the postoperative bmi, blood pressure, and blood glucose outcome of patients with t2dm complicated with coronary heart disease and positively impact in‐stent restenosis and mace.

Journal: Computational and Mathematical Methods in Medicine (2023)
Publication types: Research Article;
Effect of Anti-Infective Reconstituted Bone Xenograft Combined with External Fixator on Serum CRP and PCT Levels and Prognosis of Patients with Bone Infection after Lower Extremity Long Bone Trauma

Bone infection is one of the common complications of orthopedic surgery.After bone trauma occurs in the human body, the infection of staphylococcus aureus and gram-negative bacteria into the fracture area can lead to double infection of the soft tissue and bone tissue at the fracture site, leading to a variety of complications, mostly in the lower extremities.Bone infection easily causes bone destruction, bone nonunion, and bone defect, seriously affecting the quality of life of patients.The traditional treatment method of bone infection is to control the infection first and then repair the bone graft, but this method has a long course, poor efficacy, and high disability rate.In this study, anti-infective reconstituted bone xenograft (arbx) combined with external fixation was used to treat patients with posttraumatic bone infections of the long bones of the lower extremities, to explore its efficacy, and to analyze its effects on serum crp, pct levels, and prognosis.Our results showed that arbx combined with the external fixator had a good effect on the treatment of patients with bone infection after lower extremity long bone trauma, which could effectively enhance the repair and functional recovery of the limb bone, significantly alleviate the infection degree of patients, reduce the inflammatory response of the body, and have a good prognosis.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Clinical Study;
Effect of Alteplase Thrombolysis on Coagulation Function and Nerve Function of Patients with Ischemic Stroke

To investigate the effects of alteplase thrombolysis on coagulation function and nerve function of patients with ischemic stroke.Methods.76 cases with ischemic stroke receiving thrombolytic therapy in cangzhou central hospital from november 2018 to november 2019 were recruited.They were assigned via the random number table method at a ratio of 1 : 1 to receive alteplase thrombolysis either within 3h after the onset (observation group) or within 3–4.5 h after the onset (control group), followed by aspirin administration after no bleeding in cranial computed tomography (ct).Outcome measures included plasma fibrinogen (fib), activated partial prothrombin time (aptt), platelet (plt) levels, the national institute of health stroke scale (nihss) score, and adverse events.Results.Alteplase thrombolysis within 3 h was associated with better prothrombin time (pt), aptt, fib, and plt levels versus thrombolysis within 3–4.5 h ( p &lt; 0.05 ).Thrombolysis within 3 h showed significantly lower nihss scores versus within 3–4.5 h ( p &lt; 0.05 ).The two groups showed a similar incidence of adverse events (x2 = 2.963, p = 0.615 ).Conclusion.Alteplase thrombolysis showed benefits in mitigating the coagulation function and nerve function damage of patients with ischemic stroke, especially within 3 hours after the onset, with a high safety profile.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Effect Evaluation of Platelet-Rich Plasma Combined with Vacuum Sealing Drainage on Serum Inflammatory Factors in Patients with Pressure Ulcer by Intelligent Algorithm-Based CT Image

This work was to explore the efficacy of intelligent algorithm-based computed tomography (ct) to evaluate platelet-rich plasma (prp) combined with vacuum sealing drainage (vsd) in the treatment of patients with pressure ulcers.Based on the u-net network structure, an image denoising algorithm based on double residual convolution neural network (dr-cnn) was proposed to denoise the ct images.A total of 84 patients who were hospitalized in hospital were randomly divided into group a (without any intervention), group b (prp treatment), group c (vsd treatment), and group d (prp+vsd treatment).Procalcitonin (pct) was detected by enzyme-linked immunosorbent assay (elisa) combined with immunofluorescence method, c-reactive protein (crp) was detected by rate reflectance turbidimetry (rrt), and interleukin-6 (il-6) was detected by electrochemiluminescence method.The results showed that after treatment, 44 cases (52.38%) of pressure ulcers patients recovered, 24 cases (28.57%) had no change in stage, and 16 cases (19.04%) developed pressure ulcers.The pain scores of group d at 1 week ( 3.35 ± 0.56 points) and 2 weeks ( 2.76 ± 0.55 points) after treatment were significantly lower than those in group c ( 7.77 ± 0.58 points and 6.34 ± 0.44 points, respectively).The time of complete wound healing in group d ( 24.5 ± 2.32 ) was obviously lower in contrast to that in groups a, b, and c ( 35.54 ± 3.22 days, 30.23 ± 2 days, and 29.34 ± 2.15 days, respectively).In addition, the medical satisfaction of group d ( 8.74 ± 0.69 ) was significantly higher than that of groups a, b, and c ( 4.69 ± 0.85 , 5.22 ± 0.31 , and 5.18 ± 0.59 , respectively).The levels of il-6 and pct in group d were lower than those in groups a, b, and c, and the differences were statistically significant ( p &lt; 0.01 ).The average values of peak signal to noise ratio (psnr) and structural similarity index measure (ssim) of the dr-cnn network model were 37.21 ± 1.09 d b and 0.925 ± 0.01 , respectively, which were higher than other algorithms.The mean values of root mean square error (mse) and normalized mean absolute distance (nmad) of the dr-cnn network model were 0.022 ± 0.002 and 0.126 ± 0.012 , respectively, which were significantly lower than other algorithms ( p &lt; 0.05 ).The experimental results showed that pr p combined with vsd could significantly reduce the inflammatory response of patients with pressure ulcers.Prp combined with vsd could significantly reduce the pain of dressing change for patients.Moreover, the performance model of image denoising algorithm based on double residual convolutional neural network was better than other algorithms.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Diagnostic Values of Advanced Glycation End Products and Homocysteine in Patients with Alzheimer’s Disease and Sarcopenia

This study is aimed at exploring the diagnostic value of advanced glycation end products (ages) and homocysteine (hcy) in alzheimer’s disease (ad) complicated with sarcopenia (sp) and to analyze the risk factors related to ad complicated with sp.A total of 168 patients admitted to our hospital from november 2019 to december 2021 were enrolled.Patients were divided into the nc (no sp and ad) group with 29 cases, the ad group with 39 cases, the ad+sp group with 35 cases, and the sp group with 65 cases.The general information, mini-mental state examination (mmse) scores, and serum levels of ages and hcy among the four groups were compared.Unordered logistic regression was used to analyze the influencing factors of sp patients complicated with dementia.The age level was higher in the ad or ad+sp group than the nc or sp group ( p &lt; 0.05 ).There was no significant difference between the sp group and the nc group or between the ad group and the ad+sp group ( p &gt; 0.05 ).The hcy level was higher in the sp or ad group than the nc group ( p &lt; 0.05 ).There were no significant differences between the ad group and nc group or between the sp group and ad+sp group ( p &gt; 0.05 ).The roc curve of serum ages and hcy for the diagnosis of ad showed that the area under curve (auc) was 0.887, p &lt; 0.05 (95% ci: 0.821-0.954, sensitivity: 80.95%, specificity: 73.81%) and 0.7423, p &lt; 0.05 (95% ci: 0.6382-0.8465, sensitivity: 60.42%, specificity: 57.59%), respectively.The roc curve of serum ages and hcy for the diagnosis of sp showed that the auc was 0.5533, p &gt; 0.05 (95% ci: 0.4294-0.6771) and 0.8744, p &lt; 0.05 (95% ci: 0.8006-0.9483).Age ( p &lt; 0.001 ), depression ( p = 0.001 ), malnutrition ( p = 0.002 ), and bmi ( p &lt; 0.001 ) were independent influencing factors of sp complicated with ad in elderly inpatients.In conclusion, combined serum ages and hcy had a good diagnostic value for ad combined with sp, which may be helpful for early detection of patient condition.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Diagnostic Value of Color Doppler Ultrasonography in Subacute Thyroiditis

In order to explore the clinical effect of color doppler ultrasonography in the diagnosis of subacute thyroiditis, a method for the diagnosis of subacute thyroiditis by color doppler ultrasonography was proposed.From november 2019 to november 2020, 90 patients with subacute thyroiditis in our hospital were selected as the experimental group; 90 healthy people were selected as the control group during the same period.Both groups were diagnosed by color doppler ultrasonography and compared.The experimental results showed that patients with subacute thyroiditis showed mild to moderate enlargement of the involved thyroid gland, and local or diffuse inhomogeneous hypoechoic areas may appear in bilateral or unilateral thyroid glands: irregular edges, unclear boundaries, no “ball feel,” mottled changes, and accompanied by tenderness.The blood flow signal around the hypoechoic area is rich, and the internal blood flow signal is less.There was no significant increase in the blood flow velocity of the superior thyroid artery on the affected side.Color doppler ultrasound not only is simple, economical, and non-invasive but also has a good diagnostic accuracy for subacute thyroiditis, which can provide an important basis for clinical diagnosis and treatment and is worthy of popularization and application.

Journal: Scanning (2022)
Publication types: Research Article;
Diagnostic Efficacy of CT Radiomic Features in Pulmonary Invasive Mucinous Adenocarcinoma

In order to solve the problem of the effect of ct images on the diagnosis of lungs, the authors proposed a method for the diagnosis of invasive mucinous adenocarcinoma of the lungs based on ct radiomic features, and the modified method is found by reviewing past cases: among the 34 cases of primary pulmonary lymphoma, 12 cases were nodular mass type, 19 cases were nonnodular mass type, and 3 cases were mixed type; 13 cases involved bilateral lung lobes, 7 cases involved right lung, and 4 cases involved left lung example.There were 17 cases of tumor consolidation density shadow, 17 cases of mixed density shadow, the average ct value was about 32hu, 15 cases of cavitation sign, 6 cases of cavity, 9 cases of angiography sign, 30 cases of air bronchus sign, 22 cases of bronchiectasis, bronchial stenosis or amputation in 8 cases, pleural effusion in 12 cases, lymph node enlargement in 15 cases, and pleural metastasis in 2 cases.The final pathological results included 24 cases of membrane-associated lymphoid tissue (malt) lymphoma, 9 cases of diffuse large b-cell lymphoma (dlbcl), and 1 case of t-cell lymphoma.The ct manifestations of primary pulmonary lymphoma (ppl) are diverse and do not have obvious specificity, the imaging manifestations are correlated with pathological types, and air bronchial signs, bronchiectasis, angiography signs, and other signs are used for the diagnosis of ppl.This is of great significance for the diagnosis of ppl.

Journal: Scanning (2022)
Publication types: Research Article;
Diagnosis of Lumbar Spondylolisthesis Using a Pruned CNN Model

Convolutional neural network (cnn) models have made tremendous progress in the medical domain in recent years.The application of the cnn model is restricted due to a huge number of redundant and unnecessary parameters.In this paper, the weight and unit pruning strategy are used to reduce the complexity of the cnn model so that it can be used on small devices for the diagnosis of lumbar spondylolisthesis.Experimental results reveal that by removing 90% of network load, the unit pruning strategy outperforms weight pruning while achieving 94.12% accuracy.Thus, only 30% (around 850532 out of 3955102) and 10% (around 251512 out of 3955102) of the parameters from each layer contribute to the outcome during weight and neuron pruning, respectively.The proposed pruned model had achieved higher accuracy as compared to the prior model suggested for lumbar spondylolisthesis diagnosis.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Diagnosis of Liver Cirrhosis and Liver Fibrosis by Artificial Intelligence Algorithm-Based Multislice Spiral Computed Tomography

This research was aimed at investigating the artificial intelligence (ai) segmentation algorithm-based multislice spiral computed tomography (msct) in the diagnosis of liver cirrhosis and liver fibrosis.Besides, it was aimed at providing new methods for the diagnosis of liver cirrhosis and liver fibrosis.All patients were divided into the control group, mild liver fibrosis group, and significant liver fibrosis group.A total of 112 patients were included, with 40 cases in the mild liver fibrosis group, 48 cases in the significant liver fibrosis group, and 24 cases who underwent computed tomography (ct) examination in the control group.In the research, deconvolution algorithm of ai segmentation algorithm was adopted to process the images.The average hepatic arterial fraction (haf) values of patients in the control group, mild liver fibrosis group, and severe liver fibrosis group were 17.59 ± 10.03 %, 18.23 ± 5.57 %, and 20.98 ± 6.63 %, respectively.The average mtt values of patients in the control group, mild liver fibrosis group, and severe liver fibrosis group were 12.69 ± 1.78 s, 12.53 ± 2.05 s, and 12.04 ± 1.57 s, respectively.The average blood flow (bf) values of patients in the control group, mild liver fibrosis group, and severe liver fibrosis group were 105.68 ± 15.57 m l 100 g-1·min-1, 116.07 ± 16.5 m l·100 g-1·min-1, and 110.39 ± 16.32 m l·100 g-1·min-1, respectively.Besides, the average blood volume (bv) values of patients in the control group, mild liver fibrosis group, and significant liver fibrosis group were 15.69 ± 4.35 m l·log-1, 16.97 ± 2.68 m l·log-1, and 16.11 ± 4.87 m l·100 g-1, respectively.According to statistics, the differences among the average haf, mtt, bf, and bv values showed no statistical meaning.Ai segmentation algorithm-based msct imaging could promote the diagnosis of liver cirrhosis and liver fibrosis effectively and offer new methods to clinical diagnosis of liver cirrhosis and liver fibrosis.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Detection and Correlation Analysis of Serum Uric Acid in Patients with Thyroid-Associated Ophthalmopathy

To probe the property of serum uric acid in evaluating the activity of patients with thyroid-associated ophthalmopathy.Methods.A total of 443 patients with tao admitted to our hospital from march 2016 to february 2021 were selected for the observation group.Simultaneously, 443 healthy subjects were selected for the control group.The observation group was divided into the active group ( n = 254 ) and the inactive group ( n = 189 ) according to the clinical activity score (cas).Besides, the patients were divided into mild group ( n = 201 ), moderate severe group ( n = 133 ) and extremely severe group ( n = 109 ) based on the severity of tao.Serum uric acid, free triiodothyronine (ft3), free thyroid hormone (ft4), thyrotropin stimulating hormone (tsh) and glycosylated hemoglobin (hb a1c) levels were detected and analyzed in each group.Results.Serum ua, ft3, ft4, tsh and hb a1c in the active group were significantly enhanced than those in the other two groups ( p &lt; 0.05 ), and there was no significant difference between the inactive group and the control group ( p &gt; 0.05 ).In different disease severity groups, the serum ua level of patients in the active group was significantly promoted than that in the inactive group and control group ( p &lt; 0.05 ) and was decreased successively in extremely severe group, moderate severe group and mild group, with statistical significance ( p &lt; 0.05 ).Pearson’s analysis showed that ua was positively correlated with ft3, ft4, and hb a1c ( r = 0.652 , p = 0.031 ; r = 0.571 , p = 0.042 ; r = 0.737 , p = 0.024 ), while was reversely correlated with tsh level ( r = − 0.137 , p = 0.262 ).There was no correlation between ua and ft3, ft4, and hb a1c levels in the inactive group.Ua detection showed the average sensitivity and specificity of tao activity were 94.3% and 85.2%, respectively.There was no significant correlation between the severity of disease and serum ua in inactive patients ( p = 0.135 ).There was a positive correlation between the severity of disease and serum ua in active patients ( p = 0.005 ).Conclusion.Ua may be used as a laboratory indicator for quantitative clinical diagnosis of thyroid-associated ophthalmopathy (tao) and as a parameter for the presence of tao activity.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Design of Water Quality Monitoring System in Shaanxi Section of Weihe River Basin Based on the Internet of Things

Monitoring environmental water quality in an efficient, cheap, and sustainable way can better serve the country’s strategic requirements for water resources and water ecological protection.This paper takes the shaanxi section of the weihe river basin as a pilot project and aims to use the internet of things technology to develop water quality monitoring sensors, so as to realize the construction of low-cost, high-reliability water quality monitoring demonstration applications.First of all, we established the design of the water quality collection terminal, designed the low-power water quality sensor node, supported the internet of things protocol and the collection of various water quality parameters, and used networking for data transmission.Secondly, we use the ant colony algorithm-based system clustering model to obtain a cluster map of water quality monitoring tasks in a certain section of the weihe river basin.We take the task clustering graph as an example for analysis, optimize the monitoring model through the ant colony algorithm, and obtain the weight of the optimization index.The weight of the scheduled task limit of the monitoring point becomes larger, so the release of the monitoring task mainly affects the limit of the scheduled task of the monitoring point.Through the above work, we designed and implemented a set of online water quality monitoring system based on the internet of things and data mining technology.The system can provide reference for large-scale water resource protection and water environment governance.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Design of Children’s Motor Skills Training Management System Based on Human Movement Recognition Algorithm of Depth Information

With the deepening of the concept of all-round development, the training of children’s motor skills is becoming more and more popular.Children’s motor skills training management system is based on the product of children’s motor skills training combined with modern technology.This article aims to design a management system for children’s motor skills training based on human motion recognition methods.This article proposes a human motion recognition algorithm based on depth information.The traditional human motion recognition algorithm is more biased towards children’s motor skills.For the design of the system, this article also pays great attention to children’s experience.After analyzing the performance of the system in this study, it is found that the system is not ideal for multitarget human motion recognition.Therefore, this article optimizes the recognition.After the optimization, the recognition rate of the head, upper body, and lower body of the multiobjective human motion recognition is more than 80%.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Design for Bedridden Elderly: Presenting Pressure Ulcer Product Design Based on Anthropometric Characteristics

Pressure ulcers are a type of injury that causes tissue ischemia, a deficiency of nutrition and oxygen to the tissues, and, eventually, tissue necrosis when an area of skin is placed under constant pressure for an extended length of time.With the acceleration of the aging process, the problem of providing care for pressure ulcers for the bedridden elderly becomes increasingly urgent.This study conducts a field survey based on the research status of 221 disabled elderly in 16 communities on 7 typical streets in beijing, focusing on the problem of pressure ulcer complications caused by bedridden.An automatic inflatable airbag mattress is designed according to anthropometric dimensions of bedridden elderly, pressure ulcer-prone areas, and the decompression standard, so that the airbag mattress can reduce the pressure in its initial shape.To achieve accurate control of the pressure in the pressure-prone areas of an airbag, air pressure control system is proposed which can control airbags individually and link multiple airbags, evaluating the safety of pressure ulcer points based on the data from sensors and making corresponding air pressure changes to reduce the possibility of generating pressure ulcers.The proposed pressure ulcer preventing system will be an efficient healthcare tool for families who had elderly bedridden patients, patients with chronic degenerative disease side effects, and terminal and postsurgical patients, as well as femur fractures, in their homes.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;