syedzayyan/paper_mill_benchmark huggingface dataset:
Establishment of a Finite Element Model of Normal Nasal Bone and Analysis of Its Biomechanical Characteristics

Nasal bone is a long, paired series of small bones, which is narrow at the top and broad at the bottom, that forms the base of the nasal dorsum.Together with the nasal part of the frontal bone, the frontal process of the maxilla and the middle plate of the ethmoid bone constitute the bone scaffold of the external nose.In this paper, the dicom image data file was imported into the mimics software for 3d reconstruction.At the same time, the geomagic software was used for relevant image processing, and the finite element software ansys was used to establish a finite element model to analyze the stress characteristics of the nasomaxillary complex.Results.The maximum principal stress and maximum strain force at the lower segment of nasal bone and the junction of nasal bone and maxilla were relatively large.When the same external force acts on the lower segment of the nasal bone and the angle is 0° (sagittal force), the maximum principal stress and maximum strain force are the smallest.When the angle continues to increase, the maximum principal stress and maximum strain force continue to increase.

Journal: Emergency Medicine International (2023)
Publication types: Research Article;
Endophytic Fungi and Secondary Metabolites of Rehmannia Glutinosa Based on Traditional Chinese Medicine Fingerprints

Research on the active components of medicinal plants has always been the focus of research, and research on the active components of medicinal plant endophytic fungi and their secondary metabolites has also attracted widespread attention.Endophytic fungi of medicinal plants are widely distributed and are ubiquitous in various biological groups in nature.Rehmannia glutinosa contains a variety of active ingredients, which are regarded as the top grade of chinese medicinal materials.It is of certain significance to study endophytic fungi and their metabolites of rehmannia glutinosa.In this paper, endophytic fungi and their secondary metabolites of rehmannia glutinosa were studied using fingerprint technology, which initially understands the diversity of endophytic fungi in rehmannia glutinosa.In this paper, the roots and leaves of rehmannia glutinosa were used as experimental materials.The fungi were cultured in the medium, the fungi were isolated and purified by the tissue block method, the fungal growth of rehmannia glutinosa in different parts was determined, and the types of endophytic fungi were identified by microscopic identification and fingerprinting.The isolated strains were tested for biological activity using oryza oryzae spores, and highly active strains were screened.Fermentation products of endophytic fungi were separated and purified by chromatography, and the structure of the compounds was identified by nuclear magnetic resonance spectroscopy.Through the above studies, the population structure of endophytic fungi of rehmannia glutinosa was determined, 3 highly active strains were found, and the structures of 7 endophytic fungi metabolites were identified, of which 3 were newly discovered compounds.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Elevated Substance P Is a Risk Factor for Postoperative Delirium in Patients with Hip Fracture

Hip fractures are quite common worldwide, especially among the elderly, and are associated with a high incidence of postoperative delirium, which worsens functional results and increases death.The causes of postoperative delirium in patients with hip fractures are unknown, and a separate pathobiology has been hypothesized.Substance p is a neuropeptide that has been linked to a number of immune‐inflammatory and neurological conditions.The purpose of this study was to see if serum substance p levels could predict postoperative delirium in a group of hip fracture patients.Methods .A total of 148 hip fracture patients were enrolled in the study, all of whom had no substantial pre‐existing medical or cognitive issues.Demographic and regular laboratory data were gathered as a starting point.Elisa was used to examine substance p levels before and after surgery (after 1 day).Patients were then divided into two groups: “postoperative delirium” and “no postoperative delirium.” intergroup comparisons, study of delirium prevalence rates in postoperative serum substance p quartile categories, and binary logistic regression for postoperative delirium category as outcome were all done.Results .Except for serum low‐density lipoprotein (ldl) levels, there were no statistically significant variations in preoperative substance p levels or other baseline characteristics between the two groups.The “postoperative delirium” group had significantly higher postoperative substance p levels than the “no postoperative delirium” group (46.36.1 versus 31.94.7 pg/ml).There was a significant difference in postoperative delirium rates between the quartile categories of postoperative substance p, with the fourth quartile having the highest rate.Regression analysis revealed that postoperative substance p levels were related with a significantly increased or (1.265, ci: 1.172‐1.283) of postoperative delirium.Conclusion .In the current sample of hip fracture patients, a higher postoperative serum substance p level was linked to a higher risk of postoperative delirium.Further research into the utility of early postoperative serum substance p as a delirium indicator in hip fracture patients is needed.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Electrophysiological Characteristics of Cervical Spinal Stenosis

To investigate electrophysiological characteristics of patients with cervical spinal stenosis (css) due to cervical disc herniation.Methods.A total of 51 patients with css diagnosed in our hospital from january 2018 to march 2020 were selected.According to magnetic resonance imaging (mri), the degree of spinal cord compression was divided into 1-3 grades, namely, group a (mri grade 1), group b (mri grade 2), and group c (mri grade 3), with 17 cases in each group.Subsequently, we analyzed the correlation of the degree of spinal cord compression with the general information, clinical data, and electromyography (emg) of patients.Results.Compared with group a and group b, group c had the longest disease course [( 48.06 ± 17.71 ) months], the lowest joa score ( 4.59 ± 2.15 ), and the highest number of positive results of emg (emg: a/b/c, 25/51/77); there were significant differences among the 3 groups.And group c had the higher number of positive cases of both upper and lower limbs in sep test compared with the other two groups (sep: a/b/c: 12/18/29: χ 2 = 7.559 , p = 0.023 ).According to correlation analysis, mri grading had no association with gender, age, and spinal canal diameter/volume but was positively correlated with disease course and negatively correlated with joa score.Conclusion.This study primarily verifies that higher mri grade of css is associated with longer disease duration and lower joa score and emg.The obtained results secondarily demonstrate the correlation between abnormal neurological status and the mri grade.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Electromyography Wearable Device Applied to the Medical Field

Electromyography is a diagnostic practice that examines the condition of the muscles and the nerves that regulate them.It allows neuromuscular disorders and lesions to be diagnosed, categorized based on their severity, and the most appropriate related treatment to be carried out based on the type of ailment detected.A neurologist or physical therapist is usually the one who performs this type of exam.The idea of carrying out this research arises from the need to work with a device that can perform the functions described so far to apply these medical studies to sports, physiotherapy, and rehabilitation to achieve full recovery after suffering a neuromuscular injury.This paper intends to work within the internet of medical things (io mt) to connect professionals and patients through the internet and speed up diagnoses and treatments.This article discusses the design of a wearable electromyography device capable of performing the functions of acquisition, processing, and transmission of the signal generated by the muscles to diagnose and treat neuromuscular diseases or injuries.Specifically, the paper focuses on the design of a device that is capable of acquiring the signal generated by the muscles and processing the signal.

Journal: Wireless Communications and Mobile Computing (2022)
Publication types: Research Article;
Efficacy of Cold Atmospheric Plasma Therapy on Chronic Wounds: An Updated Systematic Review and Meta-Analysis of RCTs

A previous meta-analysis has revealed that cold atmospheric plasma (cap) might not be clinically beneficial to chronic wounds.However, several new randomized controlled trials (rcts) reported that cap was an effective treatment option for accelerating wound healing in chronic wounds.The purpose of this review is to incorporate these new results and evaluate the efficacy of cap in chronic wounds.Methods.The major databases, including pub med, embase, cochrane library, and web of science, were searched for articles related to cap treatment in chronic wounds until march 21, 2022.The literature retrieval and evaluation were carried out by two independent researchers.Result.A total of 13 randomized clinical trials published between 2010 and 2022 were finally included.Cap therapy showed to be more effective in reducing the area of wounds (mean difference (md): -1.74, 95%; confidence interval (ci): [-3.14, -0.33], p = 0.02 ), compared with non-cap treatments.The immediate reduction of the bacterial load was higher in the cap group than in the control group.(md: -0.37, 95%; ci: [-0.7, -0.05], p = 0.02 ).Conclusion.No significant changes were found in long-term antibacterial efficacy and pain perception between the two groups.However, more rcts of excellent methodological quality are required to confirm technical details of the source of ap and the appropriate duration of the treatment with plasma.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Meta-Analysis;Review Article;
Efficacy of Bladder Intravesical Chemotherapy with Three Drugs for Preventing Non-Muscle-Invasive Bladder Cancer Recurrence

Epirubicin, gemcitabine, and pirarubicin are widely used as first-line drugs for intravesical chemotherapy to prevent tumor recurrence after transurethral bladder tumor resection for non-muscle-invasive bladder cancer (nmibc).However, which drug is better is less discussed.A total of 335 nmibc patients administered intravesical chemotherapy underwent transurethral bladder tumor resection (turbt) in our hospital from october 2015 to october 2019.After turbt, all the patients received standard intravesical chemotherapy.Through clinical data collection and telephone follow-up, the tumor recurrence and adverse reactions of all patients after bladder perfusion treatment were counted.Recurrence was defined as new tumor appearance in the bladder.Of the 335 patients who underwent intravesical chemotherapy, 109 patients received epirubicin and 114 patients and 112 patients were given gemcitabine and pirarubicin, respectively.According to the general information of the patients, the patients were divided into intermediate-risk and high-risk bladder cancer and compared separately.There was no statistical difference in clinical and pathological features between different groups ( p &gt; 0.05 ).The recurrence rate of intermediate-risk bladder cancer patients shows no difference between three groups ( p &gt; 0.05 ).As for the high-risk bladder cancer patients, it is found that the 1-year recurrence rate between three groups was not statistically significant ( p &gt; 0.05 ), whereas the 2-year recurrence rate of patients given gemcitabine (9.87%) was significantly lower than that of epirubicin (25.37%) and pirarubicin (24.32%), and the difference was statistically significant ( p &lt; 0.017 , bonferroni adjusted p value).The kaplan–meier survival curves showed that the recurrence-free survival rate of patients received gemcitabine was significantly higher than that of the other two groups.Comparing the incidence of adverse reactions during the infusion of the three groups of patients, the differences were not statistically significant ( p &gt; 0.05 ).In patients with high-risk non-muscle-invasive bladder cancer, the application of gemcitabine intravesical chemotherapy is related with a relatively lower recurrence rate but similar incidence of adverse reactions.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Efficacy of Analgesic Propofol/Esketamine and Propofol/Fentanyl for Painless Induced Abortion: A Randomized Clinical Trial

Patients have widely accepted abortion as a remedy for contraceptive failure all over the world.Esketamine is a new anesthetic, sedative, and analgesic drug.Fentanyl is an opioid receptor agonist and a commonly used sedative.It is necessary to choose appropriate sedative drugs for painless abortion.Methods .We selected 238 cases of painless induced abortion from january 2020 to january 2022.We collected surgical parameters, the performance of sedation, and postoperative scales with complications before and after the operation.Spss 21.0 was used to analyze data.Results .Surgical indicators between intervention and control groups had no difference; the preoperative indicators including intraoperative bispectral index (bis), systolic blood pressure (sbp), diastolic blood pressure (dbp), and pulse oxygen saturation (sp o2) had no difference between the two groups.But after surgery, experiment groups had a higher value than the control group in these four indicators.The incidence of postoperative complications including nausea and vomit had no significant difference while the experiment group had a lower r ‐value than the control group in hypotension, bradycardia, decreased oxygen saturation, and respiratory depression.The postoperative vas score and ramsay score in the experimental group were lower than those in the control group.Conclusion .Since esketamine had better sedation performance, reduce the risk of cardiovascular and respiratory depression during sedation, and reduce the pain scale compared with fentanyl, we supported that propofol/esketamine is a good choice for patients receiving a painless induced abortion, and it is a sedation plan worth promoting and further analysis.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Efficacy and Safety of Tripterygium Wilfordii Glycoside Tablets Combined with Acitretin Capsules in the Treatment of Moderate to Severe Plaque Psoriasis: A Randomized Controlled Trial

To probe into the clinical efficacy of tripterygium wilfordii glycoside (twgs) tablets combined with acitretin capsules in the treatment of patients with moderate to severe plaque psoriasis (mspp).Methods.Thirty-six patients with mspp were collected and divided into three groups, namely, group a ( n = 12 , twg tablets + acitretin capsules), group b ( n = 12 , compound glycyrrhizin capsules + acitretin capsules), and group c ( n = 12 , acitretin capsules).The general data of the patients was recorded.In addition, a comparison was made before treatment, 4 weeks and 8 weeks after treatment in terms of the clinical efficacy, liver function indicators (alanine aminotransferase (alt), aspartate transaminase (ast), and creatinine), psoriasis area, and severity index (pasi) scores.The incidence of adverse reactions after treatment and the recurrence rate during two months of follow-up was statistically analyzed.Results.The therapeutic effect of group a was superior to the other two groups, with obviously more satisfactory results of serum parameters, clinical efficacy and pasi score, and incidence of adverse reactions.Conclusions.Twgs combined with acitretin had better therapeutic effects and higher safety in the treatment of mspp.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Clinical Study;
Efficacy and Safety of N-Acetylcysteine for Chronic Obstructive Pulmonary Disease and Chronic Bronchitis

Patients with chronic obstructive pulmonary disease (copd) and chronic bronchitis are associated with poor clinical outcomes.N ‐acetylcysteine (nac) is a widely used therapeutic option for such patients; however, the clinical efficacy of nac has not been conclusively determined.We hypothesized that high‐dose oral nac can improve the clinical outcomes for patients with concurrent chronic bronchitis and copd.Objective and methods .This was a randomized, double‐blind, placebo‐controlled trial evaluating the efficacy of high‐dose nac for copd patients with concurrent chronic bronchitis.Study participants were randomized into two groups and administered with nac (900 mg) twice daily or matching placebo for 3 months.Then, respiratory health status was evaluated using the st.George’s respiratory questionnaire (sgqr), which was set as the primary end point.Results .A total of 143 copd patients with chronic bronchitis were screened, and as a result, only 100 patients were enrolled in this study (50 participants were randomized to receive placebo, and others were randomized to receive nac).After treatment, differences in sgqr scores between the placebo and nac groups were not significant.Moreover, differences in secondary end points between the two groups after treatment were insignificant.Discussion .High‐dose nac has no marked clinical benefits for copd patients with concurrent chronic bronchitis.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Efficacy and Clinical Value of Negative-Pressure Wound Therapy with Instillation (NPWTi) of Compound Phellodendron Liquid in the Treatment of Diabetic Foot Ulcer: A Prospective Cohort Study

To evaluate the efficacy and application value of compound phellodendron liquid (cpl) for negative-pressure wound therapy with instillation (npwti) in the treatment of diabetic foot ulcers by observing the improvement of diabetic foot ulcers.Methods.Sixty patients with diabetic foot ulcers who met the inclusion criteria were admitted to the department of peripheral blood vessels (wound repair) of chongqing hospital of traditional chinese medicine from august 2020 to august 2021.The random number table method divided it into the cpl npwti group and normal saline npwti group, with 30 cases in each group.The experimental group adopted fufang huangbaiye for npwti, and the control group used normal saline for npwti.The treatment effect was evaluated by baseline index, wound healing observation index, inflammatory factor index, pain scores during dressing change, and the number of days in hospital.Results.After 10 days of treatment, the symptom integration, procalcitonin (pct), and c reactive protein (crp) of the cpl npwti group were significantly reduced compared with the normal saline npwti group, while there was no obvious difference between wound area and erythrocyte sedimentation rate (esr).The wound area, symptom integral, pct, esr, and crp of the cpl npwti group were significantly reduced compared with the normal saline npwti group after treatment for 20 days and 30 days.The positive proportion of bacterial culture in the cpl npwti group was significantly reduced compared with the normal saline npwti group after treatment for 10 days, 20 days, and 30 days.After treatment, the pain scores during dressing change and the number of days in hospital in normal saline npwti group were significantly lower than those in the cpl npwti group.Conclusion.Compound phellodendron liquid npwti therapy can improve diabetic foot ulcers, providing a safe and effective method for treating diabetic foot ulcers.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Efficacy and Adverse Reactions of Arthroscopic Half-Moon Plate Invasive Surgery in Patients with Acute Knee Pain (AKP): Systematic Review and Meta-Analysis

To evaluate the efficacy and adverse reactions of arthroscopic half-moon plate invasive surgery (deb) in patients with knee pain (akp) using meta-analysis techniques.Methods.The computer retrieves from the english databases pub med, embase, cochrane library, and web of science and the chinese databases china knowledge network, wanfang database, vip database, and china biomedical literature database to collect information about deb therapeutic akp randomized controlled trial.Develop criteria for documentation inclusion and exclusion, evaluate the quality and bias risk of literature, and compare differences in efficacy and adverse responses before and after deb treatment and other conservative treatments.Results.A total of 14 randomized controlled trials and 1464 akp patients were included in the study, with follow-up duration of 1-12 months.The total knee scores for deb at 1, 3, 6, and 12 months after treatment were significantly better than baseline levels (1 month: wmd = 34.56 , p = 0.02 ; 3 months: wmd = 27.73 , p = 0.0001 ; 6 months: smd = 2.38 , p = 0.0001 ; 12 months: smd = 1.69 , p = 0.001 ).At 6 months of follow-up, deb improved knee function better than ha ( smd = 0.47 , p = 0.003 ), and during follow-up for 12 months, deb relieved knee pain ( smd = 0.55 , p = 0.0007 ) and improved knee function ( smd = 0.88 , p = 0.0001 ) which is significantly better than ha.Deb was less effective at improving knee function in 1, 3, and 12 months than deb joint ha injections (1 month p = 004 ; 3 months p = 0.01 ; 12 months p = 0.03 ).At 6 and 12 months of follow-up, deb was better at pain relief and improved function than ozone ( p &gt; 0.05 ).Deb and glucocorticosteroids have similar effects in pain relief and improved function at various follow-up times.In terms of adverse reactions, deb does not increase the risk of adverse events compared to ha ( or = 0.96 , p = 0.85 ).Conclusion.Compared to ha and ozone, deb is a more effective treatment for akp joints, while deb is combined with ha.The clinical efficacy of injection therapy akp is better than that of deb alone.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Meta-Analysis;
Effects of Quadruple Therapy Combined with Probiotics on Helicobacter Pylori-Related Peptic Ulcer

The present study was designed to observe the effect of quadruple therapy combined with probiotics on helicobacter pylori-related peptic ulcer.The patients in the control group ( n = 90 ) were given regular quadruple therapy including proton pump inhibitor ilaprazole enteric-coated tablet + two antibiotics amoxicillin dispersible tablet and metronidazole tablet + colloidal bismuth pectin capsule for 2 weeks.Patients in the study group ( n = 90 ) were given abovementioned quadruple therapy combined with probiotics live combined bifidobacterium, lactobacillus, and enterococcus capsules, oral for 2 weeks.Then hp clearance rate, recurrence rate, levels of gastrointestinal hormone makers, and advance reactions between two groups were compared.At the 2nd week after the treatment, the helicobacter pylori clearance rate in the study group (87.79%) was significantly higher than the control group (78.89%), and the total recurrence rate in the study group (6.67%) was significantly lower than the control group (13.33%) ( p &lt; 0.05 ).Serum gastrin and motilin expression were lower, and somatostatin expressions was significantly higher than those in the control group ( p &lt; 0.05 ).There was no significant difference in the total incidence of adverse reactions between the two groups ( p &gt; 0.05 ).In summary, quadruple therapy combined with probiotics in the treatment of helicobacter pylori-related peptic ulcer can improve the helicobacter pylori clearance rate, reduce the helicobacter pylori recurrence rate, and is beneficial to improving the level of gastrointestinal hormones, with certain safety.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;