syedzayyan/paper_mill_benchmark huggingface dataset:
NMR Metabolite Profiling in the Quality and Authentication Assessment of Greek Honey-Exploitation of STOCSY for Markers Identification.

Honey is a natural, healthy commodity and is probably among the most complex foods produced by nature.It is the oldest recorded and certainly the only natural sweetener that can be used by humans without any further processing.Nowadays, the increase in honey's value, along with its growing list of healthy attributes, has made the present raw material a prime target for adulteration.In the current study, nmr-based metabolite profiling in combination with chemometrics was applied in the quality control of greek honeys from northeastern aegean islands.Moreover, statistical total correlation spectroscopy (stocsy) was employed for the first time as a dereplication and structural elucidation tool in the honey biomarker identification process.A total of 10 compounds were successfully identified in honey total extracts via1h nmr spectroscopy.Compounds such as 5-(hydroxymethyl)furfural, methyl syringate, a mono-substituted glycerol derivative and 3-hydroxy-4-phenyl-2-butanone, among others, were identified as potential biomarkers related to the botanical and geographical origin of the samples.High-resolution mass spectrometry (hrms) was used as an additional verification tool on the identified compounds.

Journal: Foods (Basel, Switzerland) (2022)
Publication types: Journal Article
Impact of washing parameters on bacterial filtration efficiency and breathability of community and medical facemasks.

Can medical face masks be replaced by reusable community face masks with similar performance?The influence of the number of wash cycles, the wash temperature and the use of detergent was evaluated on the performance of one medical face masks (mfm) and ten community face masks (cfm).The performance of the new and washed masks was characterized from the bacterial filtration efficiency (bfe) and the differential pressure (dp).The tests on the new masks showed that the mfm had always better bfe than cfms.Although two of the cfms showed a bfe value exceeding 95%, only one can be classified as type i mfm based on both bfe and dp requirements.The influence of the washing parameters was investigated on the mfm and these two cmfs with excellent bfe properties.The parameters had no effect on the bfe of cfms whilst the mfm exhibited a loss in efficiency when washed with detergent.The dp of masks were not impacted by the washing.The results clearly show that even though a compromise has to be made between the bfe and breathability, it seems possible to manufacture cfms with performances similar to a type i mfm, without achieving type ii requirements.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Effects of COVID-19 pandemic restrictions on an Australian neonatal and paediatric retrieval service.

The covid-19 pandemic and associated travel and social distancing restrictions have reduced paediatric intensive care unit admissions for respiratory illnesses.The effects on retrieval (transport) services remain unquantified.Our study examined the utility of statistical process control in assessing the impact of the covid-19 pandemic on the number of neonatal and paediatric transfers in an australian retrieval service.Methods data collected prospectively from the sa ambulance service med star emergency retrieval database in south australia were analysed from january 2015 to june 2021.Statistical process control methodology, a combination of a time series analysis and assessment for common and special cause variation, was used to assess the impact of the covid-19 pandemic on retrieval workload (primary outcome of interest).Results a total of 5659 neonatal and paediatric transfers occurred during the study period and were included.A significant decrease in paediatric transfers occurred after the initial lockdown measures in march 2020 were announced in south australia (special cause variation).However, a similar reduction was not observed for neonatal transfers (common cause variation).Conclusion our study demonstrates that statistical process control may be effectively used to understand the effects of external events and processes on usual activity patterns in the retrieval setting.We found a reduction in retrieval numbers for paediatric transfers but no effect on neonatal transfer numbers.The decline in paediatric transfers was primarily attributed to reduced respiratory cases.

Journal: Journal of paediatrics and child health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Safety evaluation of the food enzyme glucose oxidase from the genetically modifiedTrichoderma reeseistrain AR-352.

The food enzyme glucose oxidase (β-d-glucose:oxygen 1-oxidoreductase; ec 1.1.3.4) is produced with the genetically modified trichoderma reeseistrain ar-352 by ab enzymes gmb h.The genetic modifications do not give rise to safety concerns.The food enzyme is free from viable cells of the production organism, but the absence of its recombinant dna could not be established.The food enzyme is intended to be used in four food manufacturing processes, namely baking processes, cereal-based processes, grain treatment for the production of starch and gluten fractions, and egg processing.Since residual amounts of total organic solids (tos) are removed by repeated washing during the production of starch and gluten, dietary exposure was calculated only for the remaining three processes.Dietary exposure to the food enzyme-tos was estimated to be up to 0.13 mg tos/kg body weight (bw) per day in european populations.Genotoxicity tests did not indicate a safety concern.The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats.The panel identified a no observed adverse effect level of 1,000 mg tos/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, results in a margin of exposure of more than 7,800.A search for similarity of the amino acid sequence of the food enzyme to known allergens was made and one match was found.The panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is considered to be low.Based on the data provided, the panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.

Journal: EFSA journal. European Food Safety Authority (2022)
Publication types: Journal Article
The effect of simultaneously and sequentially delivered cognitive and aerobic training on mobility among older adults with hearing loss.

Older adults exhibit declines in auditory and motor functioning, which are compensated for through the recruitment of cognitive resources.Cognitive or physical training alone has been shown to improve cognitive functioning and transfer to motor tasks, but results are mixed when these are combined in studies of healthy older adults, and few studies have included those with age-related hearing loss (arhl), who are at a higher risk of falls.Research question to examine format effects in mixed training, we used a repeated measures intervention design to compare the efficacy of simultaneous and sequential multimodal training formats.Methods 42 older adults (mage= 68.05, sdage= 4.65, females = 26) with (arhl) and without hearing loss (oah) completed an intervention study consisting of 12 sessions of multimodal training (computerized cognitive dual-task and recumbent aerobic cycling).Participants were randomly assigned to either the simultaneous (concurrent cognitive and aerobic) or sequential training group (cognitive followed by aerobic) and completed assessments of single- and dual-task mobility concurrent with an auditory working memory task.Training gains were assessed with repeated measures anovas using magnitude of improvement from pre- to post-training on primary outcome measures as the dependent variable.Results gains in auditory working memory were greater in the sequential group than simultaneous particularly among oah.Arhl participants were unaffected by format.While all participants improved on a measure of chair rises, there was no benefit to standing balance.The results demonstrate an advantage to sequential training, suggesting a benefit to focusing on each task in isolation.Significance the gains noted in the arhl indicate the potential benefit of incorporating cognitive remediation into traditional audiological rehabilitation.Moreover, it is important to consider the cost of dividing attention when combining training.

Journal: Gait & posture (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Development of a core outcome set for the orthopaedic management of spinal dysraphism : a study protocol.

S the aim of this study is to define a core outcome set (cos) to allow consistency in outcome reporting amongst studies investigating the management of orthopaedic treatment in children with spinal dysraphism (sd).Methods relevant outcomes will be identified in a four-stage process from both the literature and key stakeholders (patients, their families, and clinical professionals).Previous outcomes used in clinical studies will be identified through a systematic review of the literature, and each outcome will be assigned to one of the five core areas, defined by the outcome measures in rheumatoid arthritis clinical trials (omeract).Additional possible outcomes will be identified through consultation with patients affected by sd and their families.Results outcomes identified in these stages will be included in a two-round delphi process that will involve key stakeholders in the management of sd.A final list including the identified outcomes will then be summarized in a consensus meeting attended by representatives of the key stakeholders groups.Conclusion the best approach to provision of orthopaedic care in patients with sd is yet to be decided.The reporting of different outcomes to define success among studies, often based on personal preferences and local culture, has made it difficult to compare the effect of treatments for this condition.The development of a cos for orthopaedic management in sd will enable meaningful reporting and facilitate comparisons in future clinical trials, thereby assisting complex decision-making in the clinical management of these children.Cite this article:bone jt open2022;3(1):54-60.

Journal: Bone & joint open (2022)
Publication types: Journal Article
"Toolbox" construction of an extremophilic nitrile hydratase from Streptomyces thermoautotrophicus for the promising industrial production of various amides.

Nitrile hydratase (nhase; ec 4.2.1.84) is widely used to synthesize the corresponding amides from nitriles, which is the most successful green biocatalyst.However, the limited acceptability of substrates and instability under harsh reaction conditions have hindered its widespread industrial application.Here, a gene encoding an extremophilic nhase from streptomyces thermoautotrophicus (s.t nhase) was successfully overexpressed in escherichia coli.The enzyme exhibited excellent thermostability, retaining >50 % of residual activity after heat treatment at 65 °c for 252 min.To further improve the catalytic performance of s.t nhase, semi-rational engineering of its substrate access tunnel was performed.A mutant βl48d showed a specific activity of 566.18 ± 18.86 u/mg towards 3-cyanopyridine, which was 7.7 times higher than its parent enzyme (73.80 ± 5.76 u/mg).Molecular dynamics simulation showed that the introduction of aspartic acid into βleu48 resulted in a larger and more frequent opening of the substrate access tunnel entrance.On this basis, a "toolbox" containing various mutants on the substrate access tunnel was further established, whose catalytic activity towards various nitrile substrates was extensively improved, showing great potential for efficient synthesis of multiple high-value amides.

Journal: International journal of biological macromolecules (2022)
Publication types: Journal Article
The prognostic utility of personality traits versus past psychiatric diagnoses: Predicting future mental health and functioning.

Past psychiatric diagnoses are central to patient case formulation and prognosis.Recently, alternative classification models such as the hierarchical taxonomy of psychopathology (hi top) proposed to assess traits to predict clinically-relevant outcomes.The current study directly compared personality traits and past diagnoses as predictors of future mental health and functioning in three independent, prospective samples.Regression analyses found that personality traits significantly predicted future first onsets of psychiatric disorders (δr2=06-.15), symptom chronicity (δr2=.03-.06), and functioning (δr2=.02-.07), beyond past and current psychiatric diagnoses.Conversely, past psychiatric diagnoses did not provide an incremental prediction of outcomes when personality traits and other concurrent predictors were already included in the model.Overall, personality traits predicted a variety of outcomes in diverse settings, beyond diagnoses.Past diagnoses were generally not informative about future outcomes when personality was considered.Together, these findings support the added value of personality traits assessment in case formulation, consistent with hi top model.

Journal: Clinical psychological science : a journal of the Association for Psychological Science (2022)
Publication types: Journal Article
Transfusion support for a patient with alloanti-D and the RHD*DV.1 allele.

Safe blood transfusion is significantly affected by the complex antigen polymorphism and a high proportion of autoantibodies of the rh blood group system.The patient and methods a male chinese patient with primary biliary cirrhosis, esophageal and gastric rupture, and bleeding was admitted to our hospital.Blood typing identified that he had serological o and d+ blood groups.Because autoantibody was not detected using routine immediate spin (is) and indirect antiglobulin test (iat), he was treated by transfusing d+ red blood cells (rbcs).However, this treatment was ineffective.Thus, manual polybrene test (mpt) and low ionic salt solution indirect antiglobulin test (liss-iat) were performed, followed by exon sequencing of the rhd gene.Results the patient was confirmed as a dv type 1 individual by gene sequencing, and had 4+ rh d antigen agglutination.The anti-d in serum and elution could only be detected by mpt (2+ agglutination) and liss-iat methods (1+/3+ agglutination).It was presumed that attenuated alloantibody contributed to ineffective rbc transfusion, causing a transient increase in hemoglobin (hgb) before falling back to 50 g/l or even lower within four days.Conclusion genotyping helps to support the specificity of detecting autoantibodies and alloantibodies.Combining more serological methods with molecular technology in blood typing is beneficial to improve the safety and effectiveness of blood transfusion.

Journal: Clinica chimica acta; international journal of clinical chemistry (2023)
Publication types: Case Reports;Journal Article
Seismic Damage Identification Method for Curved Beam Bridges Based on Wavelet Packet Norm Entropy.

Curved beam bridges, whose line type is flexible and beautiful, are an indispensable bridge type in modern traffic engineering.Nevertheless, compared with linear bridges, curved beam bridges have more complex internal forces and deformation due to the curvature; therefore, this type of bridge is more likely to suffer damage in strong earthquakes.The occurrence of damage reduces the safety of bridges, and can even cause casualties and property loss.For this reason, it is of great significance to study the identification of seismic damage in curved beam bridges.However, there is currently little research on curved beam bridges.For this reason, this paper proposes a damage identification method based on wavelet packet norm entropy (wpne) under seismic excitation.In this method, wavelet packet transform is adopted to highlight the damage singularity information, the lp norm entropy of wavelet coefficient is taken as a damage characteristic factor, and then the occurrence of damage is characterized by changes in the damage index.To verify the feasibility and effectiveness of this method, a finite element model of curved continuous rigid-frame bridges (ccrfb) is established for the purposes of numerical simulation.The results show that the damage index based on wpne can accurately identify the damage location and characterize the severity of damage; moreover, wpne is more capable of performing damage location and providing early warning than the method based on wavelet packet energy.In addition, noise resistance analysis shows that wpne is immune to noise interference to a certain extent.As long as a series of frequency bands with larger correlation coefficients are selected for wpne calculation, independent noise reduction can be achieved.

Journal: Sensors (Basel, Switzerland) (2021)
Publication types: Journal Article
Higher extracellular water to total body water ratio was associated with chronic kidney disease progression in type 2 diabetes.

We studied the association between extracellular volume status and chronic kidney disease (ckd) progression; and the role of extracellular volume excess as a potential mediator in the relationship between matrix metalloproteinases (mmp)-2 and ckd progression in type 2 diabetes mellitus (t2dm).Methods we conducted a prospective cohort study of 1079 t2dm patients.Bioelectrical impedance analysis (bia) was performed to assess body fluid status.Results after up to 8.6 years of follow-up, 471 (43.7%) patients experienced ckd progression.In the fully adjusted model, extracellular water (ecw)/ total body water (tbw)ratios 0.39-0.40 and > 0.40 were associated with 45% and 78% higher risk of ckd progression respectively.Patients with an increase in ecw/tbw ratio had 40% higher risk of ckd progression compared to those with no change or reduction of ecw/tbw ratio.Higher ecw/tbw ratio accounted for 17.4% of the relationship between mmp-2 and ckd progression in t2dm (p = 0.026).Conclusions extracellular volume excess was independently associated with ckd progression in t2dm.Higher ecw/tbw ratio mediated the positive association between mmp-2 and ckd progression.Further studies are needed to elucidate the role of extracellular volume excess in deterioration of renal function.

Journal: Journal of diabetes and its complications (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Phase II clinical trial of personalized VCD-VTD sequential therapy using the Vulnerable Elders Survey-13 (VES-13) for transplant-ineligible patients with newly diagnosed multiple myeloma.

The vulnerable elders survey-13 (ves-13) is a well-studied simplified frailty screening tool for elderly patients in the oncology setting.We conducted a prospective clinical trial to evaluate the efficacy and safety of dose-adjusted treatment based on the ves-13 in transplant-ineligible patients with newly diagnosed multiple myeloma (mm).In the fit group (ves-13 <3), patients were treated with 4 cycles of standard-dose vcd (bortezomib, cyclophosphamide, and dexamethasone) followed by 4 cycles of standard-dose vtd (bortezomib, thalidomide, and dexamethasone).In the frail group (ves-13 ≥3), patients were treated with 4 cycles of reduced-dose vcd followed by 4 cycles of reduced-dose vtd.The median age was 75 years (66-86 years), and 34% of the cases were classified as ps 3.Among the fit group (n=16), the overall response rate (orr) was 87.5%.Among the frail group (n=31), the orr was 87.1%.There were no significant differences in progression-free survival (pfs) and overall survival (os) between the fit and frail groups (3-year pfs: 68.8% vs 53.3%, p = 0.658; 3-year os: 70.0% vs 77.6%, p = 0.919).Personalized vcd-vtd sequential therapy based on the ves-13 was associated with high response rates and showed acceptable safety in elderly frail patients with mm.The study is registered as umin000011235.

Journal: Annals of hematology (2021)
Publication types: Clinical Trial, Phase II;Journal Article
Antipsychotics and the microbiota.

Of review the gut microbiota has been speculated to underpin metabolic changes associated with chronic antipsychotic use.The change in the gut microbiota can also cause abnormal absorbtion from the gut into the blood stream (leaky gut syndrome) that can lead to inflammatory reactions, and thus, secondary damage to the brain and central nervous system.Our article aims to highlight relevant research on antipsychotic's effect on the microbiota and to point out future directions.Recent findings antipsychtoic use can result in specific microbiota changes, and it is important to differentiate this from the innate microbiota of the patient.It is important to treat these microbiota changes, as they are correlated with obesity, which is a negative contributor to the cardiovascular health of those suffering with schizophrenia.Ways to prevent antipsychotic-induced side-effects include antibiotic treatment, histamine 3 receptor blockade and metformin use.Summary given the dearth of current literature, more research is needed, however, to determine, which comes first in people with schizophrenia--an abnormal gut microbiota that elevates one's risk for schizophrenia or psychopharmacologic treatment of schizophrenia leading to secondary microbiota abnormalities or the negative symptoms of schizophrenia leading to obesity and its associated microbiota changes.

Journal: Current opinion in psychiatry (2020)
Publication types: Journal Article;Review
Network analysis in Gamma Knife capsulotomy for intractable obsessive-compulsive disorder.

Introduction gamma-knife ventral capsulotomy (gvc) has been suggested as an efficacious treatment for a subset of patients with treatment refractory obsessive compulsive disorder (ocd).Research question the goal of this study was to investigate neural correlates of gvc and investigate the predictive value of white matter tracts that are known to be associated with clinical outcome to deep brain stimulation (dbs).Material and methods mr images of 8 treatment-refractory ocd patients with a minimum follow-up of 3-years who underwent gvc were used to correlate lesion characteristics with symptom improvement.This exploratory study investigated relations between differences in cortical grey matter structure and subcortical structures before and after gvc for responding and non-responding patients (n ​= ​6).Normative diffusion mri- based tractography was used to determine networks associated with successful lesions.Results the mean total y-bocs reduction was 19.6 after three years, resulting in a response rate of 63%.the strongest correlation with symptom improvement was found for a decrease of the left ventral diencephalon volume (r ​= ​-0.83, p ​= ​0.039).Discriminative tractography suggest streamlines connecting the prefrontal cortex with the subthalamic nucleus to be associated with clinical response.However, results could not be validated either implicating interpatient anatomical variability or reflecting the relative small sample size as a limitation.Discussion/conclusion taken together, the present study highlights the efficacy of gvc in patients with treatment-refractory ocd.Our results are suggestive of gvc treatment efficacy being mediated by the involvement of a subpart of the alic connecting the pfc and the stn.

Journal: Brain & spine (2022)
Publication types: Journal Article