syedzayyan/paper_mill_benchmark huggingface dataset:
Secretive fish diversity: A new species of Listrura (Siluriformes, Trichomycteridae) from a supposedly well-known river in south-eastern Brazil.

The trichomycterid catfish listrura menezesi, new species, is described from a flooded area adjacent to rio das panelas, rio são joão basin, cachoeiras de macacu municipality, rio de janeiro state, brazil.It represents a most valuable remnant of atlantic forest biome that still resists the devastation of brazilian coastlands.Listrura menezesi can be distinguished from its congeners, except l.Boticario and l.Depinnai, by the absence of a dorsal fin.It mainly differs from l.Boticario and l.Depinnai by a continuous midlateral dark stripe along the entire body (vs.Discontinuous) and a longitudinal row of irregular dots along the dorsal limit of the abdomen extending for nearly the entire body (vs.Only on the posterior half of the body in l.Boticario and not forming a distinct row in l.Depinnai).Although the new species shares with l.Boticario and l.Depinnai the absence of dorsal fin, recent phylogenetic analyses show a close relationship between l.Menezesi and l.Macaensis, the latter having a dorsal fin.A putative apomorphic condition for this clade is presented: the abrupt widening on the mesethmoid axis starting posteriorly on the horizontal through the middle region of the autopalatine (vs.Anteriorly, on the horizontal through the anterior region of the autopalatine).Listrura menezesi comes as an addition to the ichthyofauna of the rio são joão drainage, a region extensively sampled for the past 20 years and supposedly well known.This paper also highlights the vulnerability of this species and the possibility of its disappearance in the near future.

Journal: Journal of fish biology (2022)
Publication types: Journal Article
Mechanism of chiral recognition by enantiomorphous cytosine crystals during enantiomer adsorption.

The quest to understand why life exhibits chirality has been far from successful.In the terrestrial theory of chirality emergence in living matter, one of the main possible mechanisms is the chiral recognition of organic molecules by enantiomorphic crystals.In this work, we studied the ability of enantiomorphic cytosine crystals, obtained by viedma ripening, for chiral recognition by enantiomers adsorption.For this, we used md calculations, inverse gas chromatography, and adsorption from solutions.The difference between the isotherms of enantiomers was determined using a t-test.We found that cytosine crystals were capable of chiral recognition only when the adsorbate concentration on the surface was sufficient for lateral interactions leading to layer formation.In order to approximate adsorption isotherms, langmuir, freundlich, bet, and fowler-guggenheim equations were used.The difference in lateral interactions between menthol enantiomers during their adsorption from a solution in n-heptane was established.A mechanism of chiral recognition of the adsorbed substance by cytosine crystals was proposed.The conditions under which chiral recognition could proceed were determined.We observed that, upon adsorption from a solution, chiral recognition manifested itself at higher coverages than in md simulations.This was caused by the competitive adsorption of the solvent.The results obtained show that adsorption on enantiomorphic crystals could be the source of the first minute enantiomeric excess, providing an opportunity to understand the origin of chiral imbalance.

Journal: Physical chemistry chemical physics : PCCP (2021)
Publication types: Journal Article
Economic value of three grassland ecosystem services when managed at the regional and farm scale.

Grasslands cover a major share of the world's agricultural land and their management influences ecosystem services.Spatially targeted policy instruments can increase the provision of ecosystem services by exploiting how they respond to spatial differences in environmental characteristics such as altitude, slope, or soil quality.However, most policy instruments focus on individual farms, where spatial differences are small.Here we assess the economic value of three grassland ecosystem services (i.e., forage provision, carbon sequestration, and habitat maintenance) and its variability in a swiss region of 791 km2that consists of 19,000 farmland parcels when managed at the regional and farm scale, respectively.Our spatially explicit bio-economic simulation approach combines biophysical information on grassland ecosystem services and their economic values.We find that in our case study region, spatial targeting on a regional scale management increases the economic value of ecosystem services by 45% compared to targeting at farm scale.We also find that the heterogeneity of economic values coming from prices and willingness to pay estimates is higher than the economic gains from spatial targeting that make use of the spatial difference in environmental characteristics.This implies that heterogeneity in prices and/or societal demand of these three ecosystem services is more important for grassland management than spatial heterogeneity in our case study region.The here applied framework allows for an ex-ante assessment of economic gains from spatial targeting and thus provides basic information for the implementation of incentive mechanisms addressing the nexus of food production and ecosystem service provision in grasslands.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Determinants of quality of life in individuals with chronic low back pain: a systematic review.

Chronic low back pain (clbp) is a prominent medical condition that can affect an individual at some point in their life time which could lead to poor quality of life (qol).Low back pain has affected approximately 577 million individuals globally by 2017.The aim of the current systematic review is to synthesise the existing evidence on the factors influencing the qol in individuals with clbp and to identify strategies to improve their qol.Method pub med, science direct, psych net and google scholar were used to extract studies reporting quantitative relationships between qol and its possible determinants in individuals having clbp and the intervention strategies to improve qol.Results 10,851 studies were initially identified and twenty-six studies which met the inclusion criteria were selected for the review.21 studies reported relationship between qol and potential determinants and five studies assessed the influence of interventions on qol.Determinants were classified as kinesiophobia, fear avoidance belief, or pain belief; occupation-related factors; pain and disability; activity; personal factors including age, gender, employment status; and other psychological factors including anxiety, quality of sleep, and health locus of control.Intervention strategies including mbsr, pilates method and back school programme improved qol in individuals with clbp.Conclusion psychosocial factors as well as the physical status of the individual contributed to the qol in individuals having clbp.

Journal: Health psychology and behavioral medicine (2022)
Publication types: Journal Article;Review
LncRNAs in tumor metabolic reprogramming and immune microenvironment remodeling.

Evidence accumulated over the past decade has verified that long non-coding rnas (lnc rnas) exert important functions in multiple cell programs.As a novel class of cellular regulatory molecules, lnc rnas interact with different molecules, such as dna, rna or proteins, depending on their subcellular distribution, to modulate gene transcription and kinase cascades.It has been widely clarified that lnc rnas play important roles in modulating metabolic reprogramming and reshaping the immune landscape and serve as hinges bridging tumor metabolism and anti-tumor immunity.Given these facts, lnc rnas, as putative regulators of tumor initiation and progression, have attracted extensive attention in recent years.In this review, we summarized the current research progress on the role of lnc rnas in tumor metabolic reprogramming and tumor-immune microenvironment remodeling, and conclude with our laboratory's contributions in advancing the clinical applications of lnc rnas.

Journal: Cancer letters (2022)
Publication types: Journal Article;Review
The potential of tebuconazole for mitigating oxidative stress caused by limited irrigation and improving sugar yield and root quality traits in sugar beet.

Water deficit is the main reason for sugar yield losses in semi-arid areas.Triazole derivatives may mitigate the harmful impacts of water stress.Therefore, this study aimed to assess the effect of tebuconazole (teb) application on antioxidants, root quality traits, and sugar yield under drought stress conditions.The treatments included three levels of irrigation set according to crop evapotranspiration (etc): 100%, 75%, and 50% etc, as well as three levels of teb (0, 25, and 50 mg l-1).While significantly increasing antioxidant and alpha-amino-nitrogen (α-amino-n) contents, limited irrigation decreased total chlorophyll content, net photosynthesis rate, leaf relative water content, the weight of roots, and sugar yield.In contrast, teb treatment resulted in a marked rise in all biological and physiological traits as well as enzymatic antioxidants.Our findings indicated that the decline in α-amino-n content might be linked to increased nr activity in response to the teb application.Our results also showed that the stress-ameliorating role of teb cannot be associated with the increase of flavonols (quercetin and rutin).Overall, the results demonstrated that teb has a high potential for ameliorating the negative impacts of limited irrigation.

Journal: Plant physiology and biochemistry : PPB (2021)
Publication types: Journal Article
Sleep preferentially consolidates negative aspects of human memory: Well-powered evidence from two large online experiments.

Research suggests that sleep benefits memory.Moreover, it is often claimed that sleep selectively benefits memory for emotionally salient information over neutral information.However, not all scientists are convinced by this relationship [e.g., j.M.Siegel.curr.Sleep med.Rep., 7, 15-18 (2021)].One criticism of the overall sleep and memory literature-like other literature-is that many studies are underpowered and lacking in generalizability [m.J.Cordi, b.Rasch.curr.Opin.Neurobiol., 67, 1-7 (2021)], thus leaving the evidence mixed and confusing to interpret.Because large replication studies are sorely needed, we recruited over 250 participants spanning various age ranges and backgrounds in an effort to confirm sleep's preferential emotional memory consolidation benefit using a well-established task.We found that sleep selectively benefits memory for negative emotional objects at the expense of their paired neutral backgrounds, confirming our prior work and clearly demonstrating a role for sleep in emotional memory formation.In a second experiment also using a large sample, we examined whether this effect generalized to positive emotional memory.We found that while participants demonstrated better memory for positive objects compared to their neutral backgrounds, sleep did not modulate this effect.This research provides strong support for a sleep-specific benefit on memory consolidation for specifically negative information and more broadly affirms the benefit of sleep for cognition.

Journal: Proceedings of the National Academy of Sciences of the United States of America (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.
Dexmedetomidine protects against acute lung injury in mice via the DUSP1/MAPK/NF-κB axis by inhibiting miR-152-3p.

Acute lung injury (ali) is a debilitating condition in clinics.Dexmedetomidine (dex) is known for its anti-apoptotic and anti-inflammatory properties.This study attempted to investigate the protective mechanism of dex in ali mice.Methods mice were pretreated with dex before model establishment by tracheal injection of lipopolysaccharide (lps).Pulmonary function indexes and wet-to-dry (w/d) ratio were measured.Pulmonary pathological changes were observed through he staining, cd31+-positive mouse pulmonary microvascular endothelial cells (mpmvecs) were counted through immunofluorescence staining, and apoptosis was detected through tunel staining.Mi r-152-3p mimic, sh-dusp1, or p38 mapk inhibitor was delivered into mpmvecs, followed by combined treatment of dex and lps.Mi r-152-3p expression, apoptosis, levels of apoptosis- and mapk/nf-κb pathway-associated proteins, and inflammatory factors were measured through rt-q pcr, flow cytometry, western blot, and elisa.The binding relationship of mi r-152-3p and dusp1 was verified through bioinformatics software and dual-luciferase assay.Ali mouse model was established after injection of mi r-152-3p antagomir.Results dex improved ali mouse pulmonary function and mitigated injury in mice and mpmvecs.Mi r-125-3p overexpression or sh-dusp1 partially abolished the protection of dex on mpmvecs.Mi r-152-3p targeted dusp1.Sh-dusp1 partially averted the protection of dex on mpmvecs.Dex inhibited the activation of the mapk/nf-κb pathway in mpmvecs mediated by lps, which was partially reversed by sh-dusp1.The p38 mapk inhibitor sb203580 antagonized the protective effect of dex on mpmvecs mediated by sh-dusp1.Similarly, downregulation of mi r-152-3p mitigated ali via the dusp1/mapk/nf-κb axis in vivo.Conclusion dex relieved ali in mice via the dusp1/mapk/nf-κb axis by down-regulating mi r-152-3p.

Journal: Pulmonary pharmacology & therapeutics (2022)
Publication types: Journal Article
Machine Learning Assisted Cervical Cancer Detection.

Cervical malignant growth is the fourth most typical reason for disease demise in women around the globe.Cervical cancer growth is related to human papillomavirus (hpv) contamination.Early screening made cervical cancer a preventable disease that results in minimizing the global burden of cervical cancer.In developing countries, women do not approach sufficient screening programs because of the costly procedures to undergo examination regularly, scarce awareness, and lack of access to the medical center.In this manner, the expectation of the individual patient's risk becomes very high.There are many risk factors relevant to malignant cervical formation.This paper proposes an approach named cerv detectthat uses machine learning algorithms to evaluate the risk elements of malignant cervical formation.cerv detectuses pearson correlation between input variables as well as with the output variable to pre-process the data.cerv detectuses the random forest (rf) feature selection technique to select significant features.Finally,cerv detectuses a hybrid approach by combining rf and shallow neural networks to detect cervical cancer.Results show that cerv detectaccurately predicts cervical cancer, outperforms the state-of-the-art studies, and achieved an accuracy of 93.6%, mean squared error (mse) error of 0.07111, false-positive rate (fpr) of 6.4%, and false-negative rate (fnr) of 100%.

Journal: Frontiers in public health (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration.

Activation of the alternative complement pathway is an initiating event in the pathology of age-related macular degeneration (amd).Unchecked complement activation leads to the formation of a pro-lytic pore, the membrane attack complex (mac).Mac deposition is observed on the choriocapillaris of amd patients and likely causes lysis of choroidal endothelial cells (cecs).Complement factor h (fh, encoded by the gene cfh) is an inhibitor of complement.Both loss of function of fh and reduced choroidal levels of fh have been reported in amd.It is plausible that reduced local fh availability promotes mac deposition on cecs.Fh is produced primarily in the liver; however, cells including the retinal pigment epithelium can produce fh locally.We hypothesized that cecs produce fh locally to protect against mac deposition.We aimed to investigate the effect of reduced fh levels in the choroid to determine whether increasing local fh could protect cecs from mac deposition.We demonstrated that si rna knockdown of fh (cfh) in human immortalized cecs results in increased mac deposition.We generated amd i psc-derived cecs and found that overexpression of fh protects against mac deposition.These results suggest that local cec-produced fh protects against mac deposition, and that increasing local fh protein may be beneficial in limiting mac deposition in amd.© 2022 the pathological society of great britain and ireland.

Journal: The Journal of pathology (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Interaction between Myricetin Aggregates and Lipase under Simplified Intestinal Conditions.

Myricetin, a flavonoid found in the plant kingdom, has previously been identified as a food molecule with beneficial effects against obesity.This property has been related with its potential to inhibit lipase, the enzyme responsible for fat digestion.In this study, we investigate the interaction between myricetin and lipase under simplified intestinal conditions from a colloidal point of view.The results show that myricetin form aggregates in aqueous medium and under simplified intestinal condition, where it was found that lipase is in its monomeric form.Although lipase inhibition by myricetin at a molecular level has been reported previously, the results of this study suggest that myricetin aggregates inhibit lipase by a sequestering mechanism as well.The size of these aggregates was determined to be in the range of a few nm to >200 nm.

Journal: Foods (Basel, Switzerland) (2020)
Publication types: Journal Article
Three-Dimensional Porous h-BC2N Based on BN Chains and Prismane C8Units for Alkali Metal Ion Battery Anodes.

Here, a new three-dimensional (3d) porous h-bc2n was designed via the assembly of prismane c8and boron nitride chains as the candidates for alkali metal ion battery anodes.By systematic calculations, it is found that h-bc2n is both thermally and mechanically stable, even at a temperature as high as 1000 k.Li ions can migrate with multiple diffusion directions in h-bc2n, and the minimum diffusion barrier is only 0.10 e v lower than that of graphite.The theoretical specific capacity of the h-bc2n anode for li is 549 m ah/g, which is higher than that reported for graphite.H-bc2n is also a promising anode for sodium (nibs) and potassium ion batteries (kibs) whose specific capacities are also large (549 m ah/g), and the energy barriers are 0.35 and 0.19 e v, respectively.Additionally, libs, nibs, and kibs exhibit voltage stability upon charging/discharging and good cycling stability.This theoretical exploration may open a new frontier in the search for more practical 3d porous structures as libs, nibs, and kibs anodes.

Journal: The journal of physical chemistry letters (2022)
Publication types: Journal Article
Preterm Complete Uterine Rupture With En Caul Expulsion.

Spontaneous uterine rupture is a catastrophic obstetric complication for both the mother and fetus.We highlight a case of a 32-year-old g2p1a0l1 hispanic female at 36 weeks gestation who presented to the labor and delivery unit with minimal prenatal care, complaining of abdominal pains and vaginal bleeding.An abdominopelvic ultrasound confirmed an empty uterus and fetal demise in the abdominal cavity, leading to an exploratory laparotomy to evacuate the fetus.At surgery, a preterm sized fetus "en caul" with intact amnions was floating in the abdominal cavity and a hemostatic, complete rupture of the anterior uterine wall was discovered.Uterus was repaired and the patient recovered postoperatively without complications.Despite the best evidence suggesting that a history of low-transverse cesarean section poses a low risk for spontaneous uterine rupture, this complication should always be considered and patients should be counseled regardless of the low risk should they desire a cesarean section.

Journal: Clinical medicine insights. Case reports (2022)
Publication types: Case Reports;Journal Article
Description of two three-gendered nematode species in the new genus Auanema (Rhabditina) that are models for reproductive mode evolution.

The co-existence of males, females and hermaphrodites, a rare mating system known as trioecy, has been considered as an evolutionarily transient state.In nematodes, androdioecy (males/hermaphrodites) as found in caenorhabditis elegans, is thought to have evolved from dioecy (males/females) through a trioecious intermediate.Thus, trioecious species are good models to understand the steps and requirements for the evolution of new mating systems.Here we describe two new species of nematodes with trioecy, auanema rhodensis and a.Freiburgensis.Along with molecular barcodes, we provide a detailed analysis of the morphology of these species, and document it with drawings and light and sem micrographs.Based on morphological data, these free-living nematodes were assigned to a new genus, auanema, together with three other species described previously.Auanema species display convergent evolution in some features with parasitic nematodes with complex life cycles, such as the production of few males after outcrossing and the obligatory development of dauers into self-propagating adults.

Journal: Scientific reports (2017)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
The Lima Surgical Protocol for Cleft Palate Repair.

A cleft team experience addressing non-syndromic cleft palate and cleft lip and palate is presented.The purpose of the present study is to compare surgical outcomes using 2 different protocols for cleft palate repair provided by a cleft team in lima, perú.Methods this is a comparative study between 2 groups of patients with non-syndromic cleft palate who were operated using different surgical protocols from 1999 to 2014.One hundred twenty-four children with non-syndromic isolated cleft palate and cleft lip and palate treated from 2007 to 2014 using a surgical protocol developed by our cleft team in lima, perú were compared with 145 children with cleft palate and cleft lip and palate treated by the same team using different protocol from 1999 to 2007.Data collection was accomplished by evaluation of symptomatic oronasal fistulas, presence of velopharyngeal insufficiency (vpi) and postoperative complications.Results statistical significant differences were observed between the 2 groups regarding the development of flap necrosis in favor of the lima protocol.No significant difference in palatal fistula and vpi rate between the 2 protocols was found.Conclusions the lima surgical protocol for cleft palate repair is an alternative strategy which uses the strengths of different surgical techniques based on the severity of the cleft.We observed better surgical outcomes using the lima protocol with regards to postoperative complications in patients with non-syndromic cleft palate.

Journal: The Journal of craniofacial surgery (2020)
Publication types: Journal Article