syedzayyan/paper_mill_benchmark huggingface dataset:
Effects of feeding extruded flaxseed on layer performance, total tract nutrient digestibility, and fatty acid concentrations of egg yolk, plasma and liver.

A study was conducted to determine the effects of graded levels of extruded flaxseed (ef) on laying hen performance, apparent total tract nutrient retention (attnr) and fatty acid concentrations of egg yolk, blood plasma and liver.Seventy-two white leghorn layers (58 weeks old; three per cage) were randomly assigned to one of four dietary treatments: 0 (control), 3, 6 and 9% of ef-supplemented diets for 8 weeks.Results showed that feed intake, egg production, feed conversion ratio and egg weight were not affected by treatments.The attnr of dry matter (p = .001) and gross energy (p = .014) was lower for layers fed 9% ef than those fed the control diet, while attnr of organic matter (p = .001) and nitrogen-corrected apparent metabolizable energy (p = .003) were lower for birds fed 6% and 9% ef compared with those fed the control diet.Relative to the control diet, feeding ef increased (p 300 mg of n-3 pufa after two weeks of feeding, while the highest of n-3 pufa concentrations were achieved for birds fed 9% ef.It was concluded that feeding ef up to 9% of the diet had no adverse effects on layer performance and increased n-3 pufa concentrations in blood plasma, liver and egg yolk.However, moderate to high levels of ef (i.e., 6% and 9% of the diet) reduced nutrient attnr and nitrogen-corrected apparent metabolizable energy.Omega-3-enriched eggs can be achieved by feeding layers ef at 6% of the diet.

Journal: Journal of animal physiology and animal nutrition (2020)
Publication types: Journal Article;Randomized Controlled Trial, Veterinary
Model of nutritional care in older adults: improving the identification and management of malnutrition using the Mini Nutritional Assessment&#x2013;Short Form (MNA&#xae;-SF) in general practice.

Despite clinical guidelines recommending routine nutrition screening, malnutrition in community-living older adults remains under-recognised.This study evaluated the uptake of a model of nutritional care in older adults designed to improve the identification and management of malnutrition.A pragmatic quasi-experimental study was conducted in eight general practices in regional new south wales between january 2017 and june 2018.Study participants comprised gps and practice nurses who participated in a training event on the identification and management of malnutrition and patients (aged >65 years) attending the practices recruited to the study.Nutritional screening was conducted using the mini nutritional assessment-short form.The specific objectives of the study were to: (1) evaluate the effects of the intervention on knowledge, attitudes and practices of staff related to malnutrition screening using questionnaires and in-depth interviews; and (2) identify patients' experiences and outcome measures following malnutrition screening through self-completed surveys.Across the eight practices, 11 healthcare professionals completed in-depth interviews.Post-training knowledge surveys (n = 25) identified that knowledge increased in 96% of staff (p < 0.001).Fifty-five older adults who were screened (two malnourished, 10 'at risk of malnutrition') reported an increased awareness of risk factors for malnutrition.This study provides proof-of-concept that a model of care that includes routine malnutrition screening and accompanying pathways for management is acceptable to general practice staff and has promising effects on patient outcomes.However, the low number of patients screened suggests that additional processes are required to improve feasibility (e.g.Incorporation into medicare-funded nurse-led consultations such as the 75+ health assessment).

Journal: Australian journal of primary health (2022)
Publication types: Journal Article
Half-Time Heat Map Reveals Ultrasonic Effects on Morphology and Kinetics of Amyloidogenic Aggregation Reaction.

Ultrasonication has been recently adopted in amyloid-fibril assays because of its ability to accelerate fibril formation, being promising in the early stage diagnosis of amyloidoses in clinical applications.Although applications of this technique are expanding in the field of protein science, its effects on the aggregation reactions of amyloidogenic proteins are poorly understood.In this study, we comprehensively investigated the morphology and structure of resultant aggregates, kinetics of fibril formation, and seed-detection sensitivity under ultrasonication using β2-microglobulin and compared these characteristics under shaking, which has been traditionally adopted in amyloid-fibril assays.To discuss the ultrasonic effects on the amyloid-fibril formation, we propose the half-time heat map, which describes the phase diagram of the aggregation reaction of amyloidogenic proteins.The experimental results show that ultrasonication greatly promotes fibril formation, especially in dilute monomer solutions, induces short-dispersed fibrils, and is capable of detecting ultra-trace-concentration seeds with a detection limit of 10 f m.Furthermore, we indicate that ultrasonication highly alters the energy landscape of an aggregation reaction due to the effect of ultrasonic cavitation.These insights contribute not only to our understanding of the effects of agitation on amyloidogenic aggregation reactions but also to their effective application in the clinical diagnosis of amyloidoses.

Journal: ACS chemical neuroscience (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Core-Shell Structured SiO2@NiFe LDH Composite for Broadband Electromagnetic Wave Absorption.

In this work, a novel core-shell structure material, ni fe layered double hydroxide (ni fe ldh) loaded on si o2 microspheres (si o2@ni fe ldh), was synthesized by a one-step hydrothermal method, and the spontaneous electrostatic self-assembly process.The morphology, structure, and microwave absorption properties of si o2@ni fe ldh nanocomposites with different ni fe element ratios were systematically investigated.The results show that the sample of si o2@ni fe ldh-3 nanocomposite has excellent microwave absorption properties.It exhibits broadband effective absorption bandwidth (rl < −10 d b) of 8.24 ghz (from 9.76 ghz to 18.0 ghz) and the reflection loss is −53.78 d b at the matched thickness of 6.95 mm.It is expected that this si o2@ni fe-ldh core-shell structural material can be used as a promising non-precious, metal-based material microwave absorber to eliminate electromagnetic wave contamination.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article
α-C(sp3)-H Arylation of Cyclic Carbonyl Compounds.

Α-c(sp3)-h arylation is an important type of c-h functionalization.Various biologically significant natural products, chemical intermediates, and drugs have been effectively prepared via c-h functionalization.Cyclic carbonyl compounds comprise of cyclic ketones, enones, lactones, and lactams.The α-c(sp3)-h arylation of these compounds have been exhibited high efficiency in forming c(sp3)-c(sp2) bonds, played a crucial role in organic synthesis, and attracted majority of interests from organic and medicinal communities.This review focused on the most significant advances including methods, mechanism, and applications in total synthesis of natural products in the field of α-c(sp3)-h arylations of cyclic carbonyl compounds in recent years.

Journal: Natural products and bioprospecting (2021)
Publication types: Journal Article;Review
Analysis of the prevalence of ankylosing spondylitis and treatment patterns and drug utilization among affected patients: an Italian real-world study.

S to evaluate the prevalence of ankylosing spondylitis (as) and associated treatment patterns and drug utilization in real-world clinical practice in italy.Methods this observational study used data from administrative databases of selected italian entities and included patients with as diagnosis identified by icd-9-cm and/or exemption codes.Patients without biologic disease-modifying antirheumatic drug (b dmard) prescriptions prior to inclusion were defined bio-naïve.A cross-sectional analysis identified treatment patterns from 2016 to 2018.A longitudinal analysis investigated b dmard utilization (persistence, switch, discontinuing treatment) among bio-naïve patients, with 2014 and 2017 as inclusion periods.Follow-up extended from first b dmard prescription (index date) to end of data availability.Results the prevalence of as was 75.5 per 100,000 (88.3 per 100,000 in adults) in 2018.In total, 5,942 as patients were identified in 2016, 6,554 in 2017, and 7,146 in 2018.B dmards were prescribed to 21.4% (2016), 22.0% (2017), and 16.9% (2018) of the patients.Among the 349 patients included in 2014, 9.5% switched therapies, 13.8% discontinued treatment.In 2017, 12.2% of the 262 patients included switched therapies, 27.1% discontinued treatment.Conclusions this study provided an up-to-date prevalence of as diagnosis in italy.Bio-naïve patients showed an increasing tendency toward switch of therapy and discontinuation.

Journal: Expert review of pharmacoeconomics & outcomes research (2022)
Publication types: Journal Article;Observational Study
Composites of waterborne polyurethane and cellulose nanofibers for 3D printing and bioapplications.

Waterborne polyurethane (pu) is a green, high performance elastomer but the viscosity of the dispersion is generally too low for direct three-dimensional (3d) printing.Composite brings additional properties while reinforcing the substrate.In the study, printable pu composites were successfully prepared by introducing cellulose nanofibrils (cnfs) and the viscosity was effectively regulated by the amount of neutralizing agent during in-situ synthesis.Rheological measurements supported the good printability.Tem images revealed that cnfs linked multiple pu nanoparticles to form a 'skewer' structure.Pu/cnf scaffolds were 3d-printed with excellent pattern fidelity and structure stability.Meanwhile, the compression modulus was much higher than the scaffolds printed with a water-soluble viscosity enhancer (peo).Fibroblasts kept proliferating in the scaffolds for two weeks.The interaction between cnf and pu may offer a novel and unique way to tune the viscosity of waterborne pu for direct 3d printing and enhance the properties of the green elastomers.

Journal: Carbohydrate polymers (2019)
Publication types: Journal Article
Tuning the Surface Properties of Poly(Allylamine Hydrochloride)-Based Multilayer Films.

The layer-by-layer (lb l) method of polyelectrolyte multilayer (pem) fabrication is extremely versatile.It allows using a pair of any oppositely charged polyelectrolytes.Nevertheless, it may be difficult to ascribe a particular physicochemical property of the resulting pem to a structural or chemical feature of a single component.A solution to this problem is based on the application of a polycation and a polyanion obtained by proper modification of the same parent polymer.Polyelectrolyte multilayers (pems) were prepared using the lb l technique from hydrophilic and amphiphilic derivatives of poly(allylamine hydrochloride) (pah).Pah derivatives were obtained by the substitution of amine groups in pah with sulfonate, ammonium, and hydrophobic groups.The pems were stable in 1 m na cl and showed three different modes of thickness growth: exponential, mixed exponential-linear, and linear.Their surfaces ranged from very hydrophilic to hydrophobic.Root mean square (rms) roughness was very variable and depended on the pem composition, sample environment (dry, wet), and the polymer constituting the topmost layer.Atomic force microscopy (afm) imaging of the surfaces showed very different morphologies of pems, including very smooth, porous, and structured pems with micellar aggregates.Thus, by proper choice of pah derivatives, surfaces with different physicochemical features (growth type, thickness, charge, wettability, roughness, surface morphology) were obtained.

Journal: Materials (Basel, Switzerland) (2021)
Publication types: Journal Article
First records of powdery mildew fungi (Erysiphales) on medicinal plants in Taiwan.

Production of medicinal plants in taiwan is not only hampered by international market competition, but also lack of knowledge of their pathogens, such as powdery mildew fungi (erysiphales, ascomycota).Records of these fungi in taiwan originate from few researchers for the last one hundred years and are still incomplete.Since powdery mildews in tropical/subtropical environments rarely develop the sexual stages with morphologically diagnostic characteristics, internal transcribed spacer sequences (its) of the ribosomal rna genes obtained from the asexual stages have become important modern tools for species identification.Results powdery mildews on medicinal plants from educational and ornamental plantations in taiwan were identified based on the anamorph morphology and its sequences.Four powdery mildews on medicinal plants are new records for taiwan, arthrocladiella mougeotii on lycium chinense, erysiphe glycines on pueraria lobata, erysiphe lespedezae on bauhinia sp., desmodium caudatum, and uraria crinita, and e.Lonicerae on lonicera japonica.Eryngium foetidum is a new host for erysiphe heraclei hitherto known on other host plants in taiwan.Eryngium foetidum and uraria crinita are new host plants for powdery mildews worldwide.Only specific field collection of the pathogens yielded the new records, not checking plant specimens in a phanerogam herbarium.The pathogens did not cause death of the host plants, but appeared to enhance stress by infection of mature leaves.Conclusions taxonomic study of powdery mildews in taiwan results into new host records of economically important medicinal plants in taiwan with potential consequences for plant production and quarantine and also shows that host records are quite incomplete worldwide.Although its sequences were useful for species identification, the lack of data for several species on the same host genus on the one hand and the low variation between closely related species on the other indicate the need for further study.

Journal: Botanical studies (2021)
Publication types: Journal Article
Comparison of Shock Index With the Assessment of Blood Consumption Score for Association With Massive Transfusion During Hemorrhage Control for Trauma.

Hemorrhage is a leading cause of early mortality following trauma.A massive transfusion protocol (mtp) to guide resuscitation while bleeding is definitively controlled may improve outcomes.Prompts to initiate massive transfusion (mt) include shock index (si) and the assessment of blood consumption (abc) score.Objective to compare si with the abc score for association with transfusion requirement, need for emergency hemorrhage interventions, and early mortality.Methods a retrospective cohort analysis of trauma mtp activations at our level i trauma center was conducted from january 1, 2012, to december 31, 2016.The study data were obtained from the trauma registry and the blood bank.An si cutoff of 1.0 was chosen for comparison with the positive abc score.Results the study cohort included 146 patients.Shock index ≥ 1 had significant association with mt requirement (p = .002) whereas a positive abc score did not (p = .65).More patients with si ≥ 1 required bleeding control interventions (67% surgery, 47% interventional radiology) than patients having a positive abc score (49% surgery, 29% interventional radiology).For geriatric patients who received mt, 65% had si ≥ 1 but only 30% had a positive abc score.Three-hour mortality following emergency department arrival was similar (60% si ≥ 1, 62% positive abc score).Conclusion shock index ≥ 1 outperformed a positive abc score for association with mt requirement.Shock index is a simple tool registered nurses can independently utilize to anticipate mt.

Journal: Journal of trauma nursing : the official journal of the Society of Trauma Nurses (2021)
Publication types: Journal Article
Impact of transitioning to an online course - A report from the ESTRO gyn teaching course.

Introduction in 2020, the estro course on image-guided radiotherapy and chemotherapy in gynaecological cancer was converted into an online version due to the covid-19 pandemic.This paper describes the change process and evaluates the impact on participants compared with previous live courses.Methods and materials the 2019 live course contained 41 h of educational content, comprising 33 h of synchronous activities (lectures, interactive activities, videos) and 8 h of homework (contouring, dose planning).For the online course, the lectures were provided as pre-course material (11 mandatory, 22 optional).Contouring/dose planning homework was unchanged.The synchronous sessions were reconfigured as six 2-hour webinars (total educational content ~38 h).participant numbers/characteristics, engagement and satisfaction for six live courses and the online course were compared.Results participant numbers for the online and live courses were similar (90 vs.Mean 96).There were more participants from outside europe (28% vs.Mean 18%) and more non-doctors (47% vs.Mean 33%).Proportion of participants responding to the pre-course questionnaire was similar (77% vs.Mean 78%) but post-course questionnaire response was lower (62% vs.Mean 92%).43% participants viewed ≥75% of mandatory lectures before the webinars.86% viewed the optional lectures.Submissions of contouring and dose planning homework was higher (contouring 77%-90% vs.56%-69%, dose planning 74%-89% vs.29%-57%).96% (47/49) participants rated the online course as excellent (43%) or good (53%).Overall satisfaction was similar (4.4 vs.Mean 4.6).Conclusion participant satisfaction and engagement with the online course remained high despite less contact time with faculty.

Journal: Clinical and translational radiation oncology (2021)
Publication types: Journal Article
Genetic diversity and relationship between cultivated, weedy and wild rye species as revealed by chloroplast and mitochondrial DNA non-coding regions analysis.

The genus secale is small but very diverse.Despite the high economic importance, phylogenetic relationships of rye species have not been fully determined, and they are extremely important for the process of breeding of new cultivars that can be enriched with functional traits derived from wild rye species.The study analyzed the degree of relationship of 35 accessions of the genus secale, representing 13 most often distinguished species and subspecies, originating from various seed collections in the world, based on the analysis of non-coding regions of the chloroplast (cp dna) and mitochondrial genome (mt dna), widely used in phylogenetic and population plant studies, because of a higher rate of evolution than the coding regions.There was no clear genetic structure between different species and subspecies, which may indicated the introgression between these taxa.The obtained data confirmed that s.Vavilovii was very similar to s.Cereale, which confirmed the assumption that they might share a common ancestor.The results also confirmed the divergence of s.Sylvestre from other species and subspecies of rye.Areas that may be useful molecular markers in studies on closely related species of the genus secale were also indicated.

Journal: PloS one (2019)
Publication types: Comparative Study;Journal Article;Research Support, Non-U.S. Gov't
Super-Resolution SERS Spectral Bioimaging.

Advances in nanotechnology enable the detection of trace molecules from the enhanced raman signal generated at the surface of plasmonic nanoparticles.We have developed technology to enable super-resolution imaging of plasmonic nanoparticles, where the fluctuations in the surface enhanced raman scattering (sers) signal can be analyzed with localization microscopy techniques to provide nanometer spatial resolution of the emitting molecule's location.Additional work now enables the super-resolved sers image and the corresponding spectrum to be acquired simultaneously.Here we will discuss how this approach can be applied to provide new insights into biological cells.

Journal: Proceedings of SPIE--the International Society for Optical Engineering (2022)
Publication types: Journal Article
Tests of Dental Properties of Composite Materials Containing Nanohybrid Filler.

Complex composite materials are used in many areas of dentistry.Initially, chemically hardened materials were also used, and in this group nanohybrid composites are highly valued.They are often used today, mainly for the direct reconstruction of damaged hard tooth tissue materials for rebuilding damaged tissues using indirect adhesive techniques.The research was conducted to determine the mechanical properties of materials with nanofillers.The article focuses on methods of important test methods for dental prosthetics: resilience, abrasion, wear test, impact strength, hardness, sem, and chemical analysis.As part of this work, five different series of hybrid composites with nano-fillers were tested.The mechanical properties of composites, such as compressive strength, microhardness, flexural strength, and modulus of elasticity, depend mainly on the type, particle size, and amount of filler introduced.The obtained test results showed that the type and amount of nanofiller have a significant influence on the mechanical and tribological properties.The introduction of nanofillers allowed us to obtain higher mechanical properties compared to classic materials discussed by other researchers.The study observed a change in vibrations in the ir spectrum, which allowed a comparison of the organic structures of the studied preparations.

Journal: Materials (Basel, Switzerland) (2022)
Publication types: Journal Article
Macular integrity assessment microperimeter, Humphrey field analyzer and OCT in glaucoma practice: a correlation study.

To compare and correlate retinal sensitivities measured with macular integrity assessment microperimetry (maia-mp) and humphrey field analyzer (hfa) 10-2 tests with structural parameters obtained from optical coherence tomography (oct) in primary open-angle glaucoma (poag) and ocular hypertension.Methods this study included 63 participants (22 with poag, 20 with ocular hypertension, and 21 control individuals).All participants underwent hfa 10-2 and maia-mp (macular retinal sensitivity tests) and measurements for optic nerve head (onh), peripapillary retinal nerve fibre layer thickness (prnflt), and ganglion cell inner plexiform layer thickness (gciplt) using oct.The relationship between macular retinal sensitivity and oct parameters was evaluated by pearson correlation analysis and linear regression modelling.Results poag cases had a strong association between the maia-mp and onh parameters (optic disc area [oda], p = 0.037; cup volume, p = 0.043), prnflt (average, p = 0.009; inferior prnflt, p = 0.004), and gciplt in all macula sectors (p ≤ 0.005 for all).Hfa 10-2 had a moderate correlation with the onh parameters (cup-to-disc ratio [cdr], p = 0.042; vertical cdr, p = 0.037; cup volume, p = 0.037; oda, p = 0.014), prnflt (average, inferior, and nasal, p < 0.05 for all), and gciplt in all macula sectors (p < 0.005 for all).Oht cases had a weak correlation between hfa 10-2 and nasal and superior prnflts (p = 0.035 and p = 0.047, respectively).Conclusion maia-mp and hfa 10-2 functional parameters have strong correlations with the structural parameters obtained by oct in poag cases.Both devices are useful in assessing the central visual field in glaucoma, with maia-mp potentially beneficial in patients with limited cooperation or poor vision.

Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie (2023)
Publication types: Journal Article