syedzayyan/paper_mill_benchmark huggingface dataset:
Access to dental care barriers and poor clinical oral health in Australian regional populations.

This paper investigated the associations between oral health with behavioural, demographic, periodontitis risk, financial and access to dental care barriers and compared the results in three australian regional areas.Methods data were obtained from the australian national study of adult oral health (2017-18).Oral health status was measured using dmft-score, and mean numbers of decayed, missing or filled teeth and periodontitis prevalence using the center for disease control and prevention (cdc) and the american academy of periodontology (aap) periodontal classification.The analysis included these dependent variables by three regional areas, seven socio-demographic variables, two periodontal disease risk factors, two preventive dental behaviours, two barriers to dental care and three access to dental care variables.Results of the 15,731 people interviewed, 5,022 were examined.There was no significant difference in periodontitis prevalence between the regions.All the socio-demographic characteristics, periodontal disease risk factors and preventive dental behaviours were significantly associated with at least one of the dental caries indicators.In multivariable analysis, there was no significant association between regional location with any of the four clinical dental caries variables.Conclusion poorer oral health outside major cities was associated with household income, education level, higher smoking, usual reason for and frequency of dental visiting.

Journal: Australian dental journal (2022)
Publication types: Journal Article
Aloperine protects beta-cells against streptozocin-induced injury to attenuate diabetes by targeting NOS1.

Type 1 diabetes (t1d) is a metabolic dysfunction characterized by the selective destruction of islet β-cells, with oxidative stress playing an essential role in the manifestation of this disease state.Aloperine (alo) represents the main active alkaloid extracted from the traditional chinese herbal sophora alopecuroides l.And features outstanding antioxidative properties.In this study, t1d was induced by a single high dose streptozotocin (stz, 150 mg/kg, intraperitoneal) in mice.Diabetic animals were intragastrically administered alo at a dose of 50 mg/kg/day.Notably, treatment of alo (50 mg/kg/day) for seven consecutive days could observably reverse the onset of diabetes induced by stz accompanied by weight gain, lower blood glucose levels, and relief of β-cells damage.Our in vitro study further demonstrated that alo protected β-cells from stz/hydrogen peroxide-induced oxidative damage as manifested by increased expression of mn sod and cat.Furthermore, a network pharmacology study revealed that nos1 represented the main target of alo.Mechanistic studies subsequently showed that treatment of alo increased the expression of nos1, whereas nos2 was decreased.Moreover, a docking study carried out suggested that alo could fit into the binding pocket of human nos1 and molecular dynamics simulation further validated this docking event.Collectively, the administration of alo prior to diabetes could be a viable approach to the prevention of β-cell injury.This study may offer a novel potential herbal medicine against t1d and may further help improve the understanding of the underlying molecular mechanisms of alo-mediated protection against oxidative stress.

Journal: European journal of pharmacology (2022)
Publication types: Journal Article
Battle of the primes - The effect and interplay of health and hedonic primes on food choice.

People making food choices are often exposed to different cues that can activate relevant goals that influence the choice outcome.Hedonic goals are frequently primed by advertising while health policy enlists primes that activate health goals in the moment of food decision-making - e.g., healthy food labels.However, little is known about the effect of such goal-priming cues on the population level and how people respond when exposed to both types of primes simultaneously.The results of this study, based on a large, representative sample (n = 1200), show no effect of health-goal priming on healthy food choices.Being exposed to a sole hedonic prime, however, reduces healthy choices by 3%.This effect completely disappeared when both primes were presented at the same time.All effects remained insensitive to people's gender, hunger status, level of dietary restraint, and bmi.These findings cast doubt over the effectiveness of health goal primes as a tool to increase healthy food choices but suggest a protective effect against competing hedonic primes and could thereby prevent less healthy choices.

Journal: Appetite (2022)
Publication types: Journal Article
High thoracic ossification of ligamentum flavum causing partial Horner syndrome.

We report a case of high thoracic ossification of the ligamentum flavum (olf) causing a partial horner's syndrome.A 57-year-old man developed a walking disorder, as well as right-sided miosis and anhidrosis.Magnetic resonance imaging demonstrated a spinal cord compressing t2-t3 olf.The patient improved after surgery.

Journal: British journal of neurosurgery (2021)
Publication types: Case Reports;Journal Article
Trimetazidine inhibits liver fibrosis and hepatic stellate cell proliferation and blocks transforming growth factor-β (TGFβ)/Smad signalingin vitroandin vivo.

Trimetazidine (tmz) has been used extensively to treat coronary artery disease and to reduce fibrosis.Liver fibrosis is a reversible process.However, the impacts of tmz on liver fibrosis triggered by ccl4and on hepatic stellate cells in liver fibrosis remain to be elaborated.In the current study, the liver fibrosis models were constructed by using ccl4-induced mice and tgf-β-induced hepatic stellate cells.The involvement of tmz in liver fibrosis was subsequently investigated.In the ccl4-induced hepatic fibrosis mouse model, it was shown that the expression levels of alanine aminotransferase and aspartate aminotransferase were reduced after tmz treatment; the expression levels of the extracellular matrix proteins colla1 and α-sma were down-regulated; furthermore, the expression levels of tgfβ/smad signaling proteins were inhibited.In tgf-β-induced hepatic stellate cells, compared to the tgf-β-induced group, cell proliferation and migration were inhibited after tmz treatment; meanwhile, extracellular matrix protein and tgfβ/smad signaling protein expression levels followed the same trend as in the hepatic fibrosis model.In conclusion, tmz could block the tgfβ/smad signaling in liver fibrosis model, with inhibiting liver fibrosis and hepatic stellate cell proliferation.This may broaden the application sphere of tmz in liver fibrosis therapy.

Journal: Bioengineered (2022)
Publication types: Journal Article
Differences in the effects of laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass on gut hormones: systematic and meta-analysis.

Laparoscopic sleeve gastrectomy (lsg) and laparoscopic roux-en-y gastric bypass (lrygb) procedures are becoming more popular in the world of bariatric surgery.Objectives this study investigates how lsg and lrygb affect gut hormones and examines their differences.Setting systematic review and meta-analysis.Methods the literature was retrieved from pub med, web of science, embase, and the cochrane library database before april 2020.Results we included 53 articles in our meta-analysis.After bariatric surgery, the patients' ghrelin, fasting acyl-ghrelin, fasting peptide yy (pyy), and their auc in the lsg group were significantly lower than those in lrygb group.Fasting ghrelin levels were significantly reduced in patients who received lsg.After lrygb, the postoperative fasting pyy was higher than at baseline, and the results were statistically significant.Additionally, we found an increase in fasting ghrelin levels after lrygb.Lastly, insulin levels were both reduced after lsg and lrygb with no significant difference.Conclusions in terms of gut hormones, ghrelin decreased significantly after lsg, while pyy increased after lrygb.However, the impacts caused by the change in gut hormones after undergoing either lsg and lrygb on patients are complicated, therefore, the results should be interpreted cautiously.

Journal: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery (2021)
Publication types: Journal Article;Meta-Analysis;Systematic Review
Theoretical and experimental evaluation of the distance dependence of fiber-based fluorescence and reflection measurements for laser lithotripsy.

S.In laser lithotripsy, a green aiming beam overlying the infrared (ir) treatment radiation gives rise to reflection and fluorescence signals that can be measured via the treatment fiber.While stone autofluorescence is used for target detection, the condition of the fiber can be assessed based on its fresnel reflection.For good applicability, fluorescence detection of stones should work even when the stone and fiber are not in direct contact.Fiber breakage detection, on the other hand, can be falsified if surfaces located in front of the fiber reflect light from the aiming laser back into it.For both applications, therefore, a fundamental investigation of the dependence of the signal amplitude on the distance between fiber and surface is important.methods.Calculations of the signal drop of fluorescence or diffuse and specular reflection with increasing fiber distance were performed using ray tracing based on a simple geometric model for different fiber core diameters.Reflection signals from a mirror, diffuse reflector, human calculi, and porcine renal tissue placed in water were measured at varying distances (0-5 mm).For human calculi, fluorescence signals were recorded simultaneously.results.The calculations showed a linear signal decrease down to ∼60% of the maximum signal (fiber in contact).The distancezat which the signal drops to for example 50% depends linearly on the diameter of the fiber core.For fibers used in lithotripsy and positioned in water,z50%ranges from 0.55 mm (200μm core diameter) to 2.73 mm, (1 mm core diameter).The calculations were in good agreement with the experimental results.conclusions.The autofluorescence signals of stones can be measured in non-contact mode.Evaluating the fresnel signal of the end face of the fiber to detect breakage is possible unless the fiber is situated less than some millimeters to reflecting surfaces.

Journal: Biomedical physics & engineering express (2022)
Publication types: Journal Article
Robust and efficient fixed-point algorithm for the inverse elastostatic problem to identify myocardial passive material parameters and the unloaded reference configuration.

Image-based computational models of the heart represent a powerful tool to shed new light on the mechanisms underlying physiological and pathological conditions in cardiac function and to improve diagnosis and therapy planning.However, in order to enable the clinical translation of such models, it is crucial to develop personalized models that are able to reproduce the physiological reality of a given patient.There have been numerous contributions in experimental and computational biomechanics to characterize the passive behavior of the myocardium.However, most of these studies suffer from severe limitations and are not applicable to high-resolution geometries.In this work, we present a novel methodology to perform an automated identification ofin vivoproperties of passive cardiac biomechanics.The highly-efficient algorithm fits material parameters against the shape of a patient-specific approximation of the end-diastolic pressure-volume relation (edpvr).Simultaneously, an unloaded reference configuration is generated, where a novel line search strategy to improve convergence and robustness is implemented.Only clinical image data or previously generated meshes at one time point during diastole and one measured data point of the edpvr are required as an input.The proposed method can be straightforwardly coupled to existing finite element (fe) software packages and is applicable to different constitutive laws and fe formulations.Sensitivity analysis demonstrates that the algorithm is robust with respect to initial input parameters.

Journal: Journal of computational physics (2022)
Publication types: Journal Article
Observation of robust flat-band localization in driven photonic rhombic lattices.

We demonstrate that a flat-band state in a quasi-one-dimensional rhombic lattice is robust in the presence of external drivings along the lattice axis.The lattice was formed by periodic arrays of evanescently coupled optical waveguides, and the external drivings were realized by modulating the paths of the waveguides.We excited a superposition of flat-band eigenmodes at the input and observed that this state does not diffract in the presence of static, as well as high-frequency sinusoidal drivings.This robust localization is due to destructive interference of the analogous wavefunction and is associated with the symmetry in the lattice geometry.We then excited the dispersive bands and observed bloch oscillations and coherent destruction of tunneling.

Journal: Optics letters (2017)
Publication types: Journal Article
Physical and antibacterial properties of bacterial cellulose films supplemented with cell-free supernatant enterocin-producing Enterococcus faecium TJUQ1.

In this study, a composite film was prepared with bacterial cellulose (bc) of gluconacetobacter xylinus and cell-free supernatant (cfs) of enterococcus faecium tjuq1, which was named bc-e.The optimum conditions for the preparation of the composite film with a minimal antibacterial activity were the soak of bc in 80 au/m l cfs for 6 h.By scanning electron microscope observation, the surface network structure of bc-e was denser than that of bc.The tensile strength of bc and bc-e was 4.65 ± 0.88 mpa and 16.30 ± 0.92 mpa, the elongation at break of bc and bc-e was 3.33 ± 0.89% and 31.60 ± 1.15%, respectively, indicating the mechanical properties of bc-e were significantly higher than that of bc (p < 0.05).The swelling ratio of bc-e (456.67 ± 7.20%) was lower than that of bc (1377.78 ± 9.07%), demonstrating bc-e films presented better water resistance.Bc-e films were soaked with 320 au/m l cfs, and then used to pack the ground meat with 6.55 log10cfu/g of listeria monocytogenes.After 8 days of storage, the number of bacteria decreased by 3.16 log10cfu/g.Similarly, total mesophilic bacterial levels in the ground meat decreased by 2.41 log10cfu/g compared to control groups.

Journal: Food microbiology (2021)
Publication types: Journal Article
Personalised 3D Printed high tibial osteotomy achieves a high level of accuracy: 'IDEAL' preclinical stage evaluation of a novel patient specific system.

High tibial osteotomy (hto) is an effective surgical treatment for isolated medial compartment knee osteoarthritis; however, widespread adoption is limited due to difficulty in achieving the planned correction, and patient dissatisfaction due to soft tissue irritation.The aim of this study was to assess the accuracy of a novel hto system with 3d printed patient specific implants and surgical guides using cadaveric specimens.Local ethics committee approval was obtained.The novel opening wedge hto procedure was performed on eight cadaver leg specimens.Whole lower limb ct scans pre- and post-operatively provided geometrical assessment quantifying the discrepancy between pre-planned and post-operative measurements for key variables: the gap opening angle and the patient specific surgical instrumentation positioning.The average discrepancy between the pre-operative plan and the post-operative osteotomy correction angle was: 0.0 ± 0.2° the r2value for the regression correlation was 0.95.The average error in implant positioning was -0.4 ± 4.3 mm, -2.6 ± 3.4 mm and 3.1 ± 1.7° vertically, horizontally, and rotationally respectively.This novel hto surgery has greater accuracy in correction angle achieved compared to that reported for conventional or other patient specific methods with published data available.This system could potentially improve the accuracy of osteotomy correction angles achieved surgically.

Journal: Medical engineering & physics (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress.

Osteoarthritis (oa), characterized as an end-stage syndrome caused by risk factors accumulated with age, significantly impacts quality of life in the elderly.Circular rnas (circ rnas) are receiving increasing attention regarding their role in oa progression and development; however, their role in the regulation of age-induced and oxidative stress-related oa remains unclear.methods:herein, we explored oxidative stress in articular cartilage obtained from patients of different ages.The presence of circ rsu1 was detected using rna sequencing of h2o2-stimulated primary human articular chondrocytes (hcs), and validated in articular cartilage and hcs using fluorescencein situhybridization (fish) staining.Mi r-93-5p and mitogen-activated protein kinase kinase kinase 8 (map3k8) were identified as interactive circ rsu1 partners based on annotation and target prediction databases, and their associations were identified through dual-luciferase reporter analysis.The effect of the circ rsu1-mi r-93-5p-map3k8 axis on hcs was confirmed using western blot, quantitative real-time pcr (q rt-pcr), enzyme-linked immunosorbent assay (elisa), immunofluorescence, and reactive oxygen species (ros) analyses.Circ rsu1 and its mutant were ectopically expressed in mice to assess their effects in destabilization of the medial meniscus (dmm) in mice.results:we found a marked upregulation of circ rsu1 in h2o2-treated hcs and oa articular cartilage from elderly individuals.Circ rsu1 was induced by il-1β and h2o2stimulation, and it subsequently regulated oxidative stress-triggered inflammation and extracellular matrix (ecm) maintenance in hcs, by modulating the mek/erk1/2 and nf-κb cascades.Ectopic expression of circ rsu1 in mouse joints promoted the production of ros and loss of ecm, which was rescued by mutation of the mir-93-5p target sequence in circ rsu1.conclusion:we identified a circ rsu1-mi r-93-5p-map3k8 axis that modulates the progression of oa via oxidative stress regulation, which could serve as a potential target for oa therapy.

Journal: Theranostics (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Criteria for the Operating Room Confirmation of the Diagnosis of Hip Instability: The Results of an International Expert Consensus Conference.

The purpose of this study was to establish an international expert consensus on operating room findings that aid in the diagnosis of hip instability.Methods an expert panel was convened to build an international consensus on the operating room diagnosis/confirmation of hip instability.Seventeen surgeons who have published or lectured nationally or internationally on the topic of hip instability were invited to participate.Fifteen panel members completed a pre-meeting questionnaire and agreed to participate in a 1-day consensus meeting on may 15, 2021.A review of the literature was performed to identify published intraoperative reference criteria used in the diagnosis of hip instability.Studies were included for discussion if they reported and intraoperative findings associated with hip instability.The evidence for and against each criteria was discussed, followed by an anonymous voting process.For consensus, defined a priori, items were included in the final criteria set if at least 80% of experts agreed.Results a review of the published literature identified 11 operating room criteria that have been used to facilitate the diagnosis of hip instability.Six additional criteria were proposed by panel members as part of the pre-meeting questionnaire.Consensus agreement was achieved for 8 criteria, namely ease of hip distraction under anesthesia (100.0% agreement), inside-out pattern of chondral damage (100.0% agreement), location of chondral damage on the acetabulum (93.3% agreement), pattern of labral damage (93.3% agreement), anteroinferior labrum chondral damage (86.7% agreement), perifoveal cartilage damage (97.6% agreement), a capsular defect (86.7% agreement), and capsular status (80.0% agreement).Consensus was not achieved for 9 items, namely ligamentum teres tear (66.7% agreement), arthroscopic stability tests (46.7% agreement), persistent distraction after removal of traction (46.7% agreement), findings of examination under anesthesia (46.7% agreement), the femoral head divot sign (40.0% agreement), inferomedial synovitis (26.7% agreement), drive-through sign (26.7% agreement), iliopsoas irritation (26.7% agreement) and ligamentum teres-labral kissing lesion (13.3% agreement).All experts agreed on the final list of 8 criteria items reaching consensus.Conclusion this expert panel identified 8 criteria that can be used in the operating room to help confirm the diagnosis of hip instability.Level of evidence level v expert opinion.

Journal: Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association (2022)
Publication types: Journal Article;Review
Optical far-field extinction of a single GaAs nanowire towards in situ size control of aerotaxy nanowire growth.

A substrate-free approach of semiconductor nanowire growth has been achieved by the aerotaxy technique previously.In this work, we propose an in situ method to monitor the size of nanowires through non-destructive optical-extinction measurements.Our work aims to build a theoretical look-up database of extinction spectra for a single nanowire of varying dimensions.We describe the origin of possible peaks in the spectra, for example due to nanowire-length dependent fabry-perot resonances and nanowire-diameter dependent tm and te mode resonances.Furthermore, we show that the au catalyst on top of the nanowire can be ignored in the simulations when the volume of the nanowire is an order of magnitude larger than that of the au catalyst and the diameter is small compared to the incident wavelength.For the calculation of the extinction spectra, we use the finite element method, the discrete dipole approximation and the mie theory.To compare with experimental measurements of randomly oriented nanowires, we perform an averaging over nanowire orientation for the modeled results.However, in the experiments, nanowires are accumulating on the quartz window of the measurement setup, which leads to increasing uncertainty in the comparison with the experimental extinction spectra.This uncertainty can be eliminated by considering both a sparse and a dense collection of nanowires on the quartz window in the optical simulations.Finally, we create a database of extinction spectra for a ga as nanowire of varying diameters and lengths.This database can be used to estimate the diameter and the length of the nanowires by comparing the position of a peak and the peak-to-shoulder difference in the extinction spectrum.Possible tapering of nanowires can be monitored through the appearance of an additional peak at a wavelength of 700-800 nm.

Journal: Nanotechnology (2020)
Publication types: Journal Article