syedzayyan/paper_mill_benchmark huggingface dataset:
Late-Onset Fabry Disease Affecting the Kidneys and Liver While Sparing the Heart: A Case Report.

Fabry disease (fd), also known as anderson-fabry disease, is an x-linked inherited lysosomal storage disorder caused by the deficiency or reduced activity of alpha-galactosidase a enzyme, which results in the accumulation of globotriaosylceramide (gb3) in the cells.Atypical (late-onset) fd is characterized by the preserved residual activity of alpha-galactosidase a enzyme resulting in a later presentation in life than classic fd.Patients with late-onset fd are usually present in their third to seventh decades of life with the heart being the most commonly affected organ.Fd can also affect the renal and gastrointestinal (gi) systems, however, in the literature, fd limited to the kidneys is scarcely reported and there is no data to suggest disease involvement of the liver.We present a rare case of late-onset fd affecting the kidneys and liver without cardiac or other organ involvement in a patient without having a family history of fd.

Journal: Cureus (2022)
Publication types: Case Reports;Journal Article
18-Item Version of the Short Gambling Harm Screen (SGHS-18): Validation of Screen for Assessing Gambling-Related Harm among Finnish Population.

And aims it is common for gambling research to focus on problem and disordered gambling.Less is known about the prevalence of gambling-related harms among people in the general population.This study aimed to develop and validate the 18-item version of the short gambling harms screen (sghs-18).Methods population-representative web-based and postal surveys were conducted in the three geographical areas of finland (n= 7186, aged 18 or older).Reliability and internal structure of sghs-18 was assessed using coefficient omega and via confirmatory factor analysis (cfa).Four measurement models of sghs-18 were compared: one-factor, six-factor, a second-ordered factor model and a bifactor model (m4).Results the analysis revealed that only the bifactor model had adequate fit for sghs-18 (cfi = 0.953, tli = 0.930, gfi = 0.974, rmsea = 0.047, srmr = 0.027).The general factor explained most of the common variance compared to specific factors.Coefficient omega hierarchical value for global gambling harm factor (0.80) was high, which suggested that sghs-18 assessed the combination of general harm constructs sufficiently.The correlation with the problem and pathological gambling measures (ppgm) was 0.44, potentially reflecting that gambling harms are closely-although not perfectly-aligned with the mental health issue of problem gambling.Sghs-18 scores were substantially higher for participants who gambled more often, who spent more money or who had gambling problems, demonstrating convergent validity for the screen.Discussion the sghs-18 comprehensively measures the domains of gambling harm, while demonstrating desirable properties of internal consistency, and criterion and convergent validity.

Journal: International journal of environmental research and public health (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Facilitators, Challenges, and Messaging Strategies for Hispanic/Latino Populations Participating in Alzheimer's Disease and Related Dementias Clinical Research: A Literature Review.

Alzheimer's disease and alzheimer's disease-related dementias (ad/adrd) disproportionally affect hispanic and latino populations, yet hispanics/latinos are substantially underrepresented in ad/adrd clinical research.Diverse inclusion in trials is an ethical and scientific imperative, as underrepresentation reduces the ability to generalize study findings and treatments across populations most affected by a disease.This paper presents findings from a narrative literature review (n = 210) of the current landscape of hispanic/latino participation in clinical research, including the challenges, facilitators, and communication channels to conduct culturally appropriate outreach efforts to increase awareness and participation of hispanics/latinos in ad/adrd clinical research studies.Many challenges identified were systemic in nature: lack of culturally relevant resources; staffing that does not represent participants' cultures/language; eligibility criteria that disproportionately excludes hispanics/latinos; and too few studies available in hispanic/latino communities.The paper also details facilitators and messaging strategies to improve engagement and interest among hispanics/latinos in ad/adrd research, starting with approaches that recognize and address the heterogeneity of the hispanic/latino ethnicity, and then, tailor outreach activities and programs to address their diverse needs and circumstances.The needs identified in this article represent longstanding failures to improve engagement and interest among hispanics/latinos in ad/adrd research; we discuss how the field can move forward learning from the experiences of the covid-19 pandemic.

Journal: Journal of Alzheimer's disease : JAD (2021)
Publication types: Journal Article;Review
COVID-19-Related Glomerulopathy: A Report of 2 Cases of Collapsing Focal Segmental Glomerulosclerosis.

Coronavirus disease 19 (covid-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (sars-co v-2), has been associated with acute kidney injury, presumably due to acute tubular injury.However, this does not explain proteinuria, sometimes severe, and hematuria often observed.We present 2 african american patients with glomerulopathy demonstrated by kidney biopsy in the setting of acute kidney injury and covid-19 infection.Kidney biopsy specimens showed a collapsing variant of focal segmental glomerulosclerosis in addition to acute tubular injury.Both patients were homozygous for apolipoprotein l1 (apol1).Covid-19 infection likely caused the interferon surge as a second hit causing podocyte injury leading to collapsing focal segmental glomerulosclerosis.apol1testing should be strongly considered in african american patients with nephrotic-range proteinuria.More data from future kidney biopsies will further elucidate the pathology of kidney injury and glomerular involvement from covid-19 infections.

Journal: Kidney medicine (2020)
Publication types: Case Reports;Journal Article
Retrospective observational study of neonatal attendances to a children's emergency department.

Attendances to emergency departments (eds) in the uk are increasing, particularly for younger children.Community services are under increasing pressure and parents may preferentially bring their babies to the ed, even for non-urgent problems.This study aimed to characterise the presenting features, management and disposition of neonatal attendances to a children's ed (ced).Methods retrospective observational review of neonatal attendances (≤28 days) to the ced at bristol royal hospital for children (brhc) from 01/01/2016 to 31/12/2016.Further information was obtained from investigation results and discharge summaries.Data abstracted included sex, age, referral method, presenting complaint, diagnosis, investigations and treatments.Results neonatal attendances increased from 655 to 1,205 from 2008 to 2016.The most common presenting complaints were breathing difficulty (18.1%) and vomiting (8.3%).The most common diagnoses were 'no significant medical problem' (41.9%) and bronchiolitis (10.5%).Half of neonatal attendances to the ced had no investigations performed and most (77.7%) needed advice or observation only.Conclusion many neonates presenting to the ced were well and discharged with observation only.This suggests potential for improving community management and in supporting new parents.Drivers of health policy should consider developing enhanced models of out of hospital care which are acceptable to clinicians and families.

Journal: Acta paediatrica (Oslo, Norway : 1992) (2021)
Publication types: Journal Article;Observational Study
Use of rose oil in probiotic fermented whey as a functional food.

Medicinal use of phytochemicals dates back to ancient times.Following that, in the 1980s those phytochemicals because of their chemical composition were used to produce new functional foods with added health benefits.Based on their positive effects, nowdays phytochemicals are integrated into the composition of various food products such as whey.This study aimed to develop a functional beverage using probiotics, inulin and rose oil (0.5%, 1% and 2%) and to reveal their effects on some quality properties of the product during 28 days of storage.lactobacillus acidophilussimultaneously with bifidobacterium animaliswere inoculated into reconstituted whey and inulin was added to enhance their growth and survival in the gastrointestinal tract.Beverage containing 0.5% rose oil (group d) was the most preferred and at the 28th day of storage contained 8.70 log10cfu/ml, which is essential for a product to have probiotic properties.Microbiological evaluations including rose oil sample showed the absence of coliform in all the samples, while total mesophilic aerobic, yeast and mould counts showed no significant differences related to rose oil during storage period.Groups c, d, e and f had low p h values while group e exhibited the highest acidity level with its highest value (1.6% la) at the 21st day.For the most part of storage period, group c had the highest levels of total solids while groups d, e and f had higher amounts of protein.Through storage duration, in all groups (except group b) the levels of ash, total solids and protein decreased.

Journal: Journal of food science and technology (2021)
Publication types: Journal Article
The co-occurrence of multidimensional loneliness with depression, social anxiety and paranoia in non-clinical young adults: A latent profile analysis.

Introduction loneliness is a negative experience arising from a mismatch between perceived and actual social relationships.Several dimensions of loneliness have been suggested, namely intimate, relational and collective loneliness.Loneliness has been linked to poorer mental health, with its co-occurrence with depression, social anxiety, and paranoia most widely reported.While expressions of these symptoms are heterogeneous across individuals in the non-clinical population, it remains unclear how these symptoms co-occur with one another and with various dimensions of loneliness.It is also of interest how trait factors such as core schemas about self/others may moderate these relationships between loneliness and co-occurring symptoms.Methods a demographically diverse sample of young adults was recruited from multiple sources.The validated sample consisted of 2,089 participants (68.4% female), who completed an online survey consisting of questionnaires assessing levels of multidimensional loneliness, depression, social anxiety, paranoia, core schemas, and demographic characteristics.Latent profile analysis (lpa) was used to identify distinct profiles of loneliness and the three symptoms.Positive and negative core schemas about self and others were modeled as predictors of these profiles.Results five distinct profiles were identified.Profile 1 had low levels across all symptoms and dimensions of loneliness (n= 1,273, 60.9%).Profiles 2-5 were elevated on dimensions of loneliness, and were heightened in depression (n= 189, 9.0%), social anxiety (n= 206, 9.9%), paranoia (n= 198, 9.5%), and all symptoms (n= 223, 10.7%), respectively.Relative to profile 1, the other four profiles scored higher on negative-self (adjusted ors= 1.36-1.49,ps< 0.001) and negative-other schemas (adjusted ors= 1.24-1.44,ps< 0.001), and lower on positive-self (adjusted ors= 0.82-0.85,ps< 0.001) and positive-other schemas (adjusted ors= 0.81-0.90,ps< 0.001).Conclusion more marked intimate, relational and collective loneliness were evident across profiles that had heightened depression, social anxiety and/or paranoia, suggesting that loneliness may serve as a general risk factor for these psychopathologies.Our findings shed light on the heterogeneity of the co-occurrence of loneliness and various mental health difficulties in non-clinical young adults.Core schemas are suggested to be putative psychological mechanisms underlying their co-occurrence and even development.

Journal: Frontiers in psychiatry (2022)
Publication types: Journal Article
Self-Healing Materials-Based Electronic Skin: Mechanism, Development and Applications.

Electronic skin (e-skin) has brought us great convenience and revolutionized our way of life.However, due to physical or chemical aging and damage, they will inevitably be degraded gradually with practical operation.The emergence of self-healing materials enables e-skins to achieve repairment of cracks and restoration of mechanical function by themselves, meeting the requirements of the era for building durable and self-healing electronic devices.This work reviews the current development of self-healing e-skins with various application scenarios, including motion sensor, human-machine interaction and soft robots.The new application fields and present challenges are discussed; meanwhile, thinkable strategies and prospects of future potential applications are conferenced.

Journal: Gels (Basel, Switzerland) (2022)
Publication types: Journal Article;Review
PUB25 and PUB26 Promote Plant Freezing Tolerance by Degrading the Cold Signaling Negative Regulator MYB15.

Cold stress adversely affects plant growth, development, and crop productivity and quality.Plants employ cold acclimation strategy to protect them from cold damage.The transcription-factor-cbf-dependent cold signaling pathway plays a key role in plant cold acclimation.However, how this signaling pathway is dynamically and precisely regulated remains unknown.Here, we report that two u-box type e3 ubiquitin ligases, pub25 and pub26, positively regulate freezing tolerance in arabidopsis thaliana.Both pub25 and pub26 poly-ubiquitinate myb15, a transcriptional repressor of the cbf-dependent cold signaling pathway, leading to myb15 degradation and thus enhanced cbf expression under cold stress.Furthermore, cold-activated ost1 specifically phosphorylates pub25 and pub26 at conserved threonine residues, enhancing their e3 activity and facilitating the cold-induced degradation of myb15.Our results thus unravel the regulatory role of the ost1-pub25/26 module in regulating the duration and amplitude of the cold response by controlling the homeostasis of the negative regulator myb15.

Journal: Developmental cell (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Redirecting Nonurgent Patients From the Pediatric Emergency Department to Their Pediatrician Office for a Same-Day Visit-A Quality Improvement Initiative.

S providing high-quality care in the appropriate setting to optimize value is a worthy goal of an efficient health system.Consequences of managing nonurgent complaints in the emergency department (ed) have been described including inefficiency, loss of the primary care-patient relationship, and delayed care for other ed patients.The purpose of this initiative was to redirect nonurgent patients arriving in the ed to their primary care office for a same-day visit, and the smart aim was to increase redirected patients from 0% of those eligible to 30% in a 12-month period.Methods the setting was a pediatric ed (ped) and primary care office of a tertiary care pediatric medical system.The initiative utilized the electronic health record to identify and mediate the redirection of patients to the patient's primary care office after ed triage.The primary measurement was the percentage of eligible patients redirected.Additional measures included health benefits during the primary care visit (vaccines, well-visits) and a balancing measure of patients returned to the ped.Results the smart aim of >30% redirection was achieved and sustained with a final redirection rate of 46%.In total, 216 of 518 eligible patients were redirected, with zero untoward outcomes.The encounter time for redirected patients was similar for those who remained in the ped, and additional health benefits were appreciated for redirected patients.Conclusions this initiative redirected nonurgent patients efficiently from a ped setting to their primary care office.The process is beneficial to patients and families and supports the patient-centered medical home.The balancing measure of no harm done to patients who accepted redirect reinforced the reliability of ped triage.The benefits achieved through the project highlight the value of the primary care-patient relationship and the continued need to improve access for patients and families.

Journal: Pediatric emergency care (2022)
Publication types: Journal Article
Effects of Half-Somersault and Brandt-Daroff exercise on dizziness, fear of fall and quality of life in patients with posterior canal benign paroxysmal positional vertigo: A randomised control trial.

The aim of this study was to compare the effects of half-somersault and brandt-daroff exercises on dizziness, fear of fall, and quality of life in patients with posterior canal benign paroxysmal positional vertigo (pc-bppv).This study was conducted from july 2020 to november 2020.A total of 20 patients were enrolled in the study, through sealed envelope method, and assigned to two groups, a and b (10 in each).Vestibular activity and participation measure and fall efficacy scale (fes) were used.The mean age of the patients was 36.70±11.58 years.There was a significant (p=0.05) difference between the vestibular activities and participation measure (vap) score at post intervention and fall efficacy scale (fes) (p<0.05) between the groups.Within group analysis showed significant results (p=0.01).This study concluded that both manoeuvers are significantly effective in the treatment of pc-bppv, but patients treated with brandt-daroff exercises reported more improvement in terms of quality of life and residual dizziness compared to the half somersault group.Clinical trials.gov identifier (nct number): nct04469309.

Journal: JPMA. The Journal of the Pakistan Medical Association (2023)
Publication types: Randomized Controlled Trial;Journal Article
Petroleum hydrocarbon rhizoremediation and soil microbial activity improvement via cluster root formation by wild proteaceae plant species.

Rhizoremediation potential of different wild plant species for total (aliphatic) petroleum hydrocarbon (tph)-contaminated soils was investigated.Three-week-old seedlings of acacia inaequilatera, acacia pyrifolia, acacia stellaticeps, banksia seminuda, chloris truncata, hakea prostrata, hardenbergia violacea, and triodia wiseana were transplanted in a soil contaminated with diesel and engine oil as tph at pollution levels of 4,370 (tph1) and 7,500 (tph2) mg kg-1, and an uncontaminated control (tph0).After 150 days, the presence of tph negatively affected the plant growth, but the growth inhibition effect varied between the plant species.Plant growth and associated root biomass influenced the activity of rhizo-microbiome.The presence of b.Seminuda, c.Truncata, and h.Prostrata significantly increased the tph removal rate (up to 30% compared to the unplanted treatment) due to the stimulation of rhizosphere microorganisms.No significant difference was observed between tph1 and tph2 regarding the plant tolerance and rhizoremediation potentials of the three plant species.The presence of tph stimulated cluster root formation in b.Seminuda and h.Prostrata which was associated with enhanced tph remediation of these two members of proteaceae family.These results indicated that b.Seminuda, c.Truncata, and h.Prostrata wild plant species could be suitable candidates for the rhizoremediation of tph-contaminated soil.

Journal: Chemosphere (2021)
Publication types: Journal Article
Reproducibility of tumor budding assessment in pancreatic cancer based on a multicenter interobserver study.

Tumor budding has been reported to be an independent prognostic factor in pancreatic ductal adenocarcinoma (pdac).Its use in daily diagnostics would improve the prognostic stratification of patients.We performed a multicenter interobserver study to test various budding assessment methods for their reproducibility.Two serial sections of 50 resected, treatment-naïve pdacs were stained for hematoxylin and eosin (h&e) and pancytokeratin.Tumor budding was scored by independent observers at five participating centers in switzerland, germany, and canada.Pathologists assessed tumor budding on a digital platform comparing h&e with pancytokeratin staining in 10 high-power fields (10hpf) and one hpf hotspot (1hpf).Additionally, tumor budding was assessed in one h&e hotspot at × 20 magnification, as suggested by the international tumor budding consensus conference (itbcc).Correlation coefficients for bud counts between centers ranged from r = 0.58648 to r = 0.78641 for h&e and from r = 0.69288 to r = 0.81764 for pancytokeratin.The highest interobserver agreement across all centers was observed for pancytokeratin 10hpfs (icc = 0.6).Icc values were 0.49, 0.48, 0.41, and 0.4 for h&e in 1hpf hotspot, h&e in 10hpfs, pancytokeratin in 1hpf, and h&e in one hotspot at ×20, respectively (itbcc method).This interobserver study reveals a range between moderately poor to moderate agreement levels between pathologists for the different tumor budding assessment methods in pdac.Acceptable levels of agreement were reached with the pancytokeratin 10hpf method, which can thus be recommended for the assessment of tumor budding in pdac resection specimens.To improve the levels of interobserver agreement, the implementation of machine learning applications should be considered.

Journal: Virchows Archiv : an international journal of pathology (2021)
Publication types: Journal Article;Multicenter Study
Long noncoding RNA XIST modulates microRNA-135/CREB1 axis to influence osteogenic differentiation of osteoblast-like cells in mice with tibial fracture healing.

Fracture healing is a complex event with the involvement of many cell systems, cytokines, as well as m rnas.Herein, we report the interactions among long noncoding rna x-inactive specific transcript (xist)/micro rna-135 (mi r-135)/c amp response element-binding protein 1 (creb1) axis during fracture healing.We observed increased expression of xist in patients with long-term unhealed fracture by microarray analysis.Subsequently, a mouse model with tibial fracture and a cell model using osteoblast-like mc3t3-e1 cells were generated.The xist overexpression during fracture healing decreased proliferation and differentiation of mc3t3-e1 cells, while silencing of xist facilitated mc3t3-e1 cell growth.Furthermore, mi r-135 targeted creb1 and negatively regulated its expression.Xist acted as a sponge for mi r-135, thereby upregulating creb1 and promoting the activity of the tnf-α/rankl pathway.Transfection of mi r-135 inhibitor or creb1 overexpression blocked the stimulating effects of xist knockdown on mc3t3-e1 cell growth.Besides, specific inhibitors of the tnf-α/rankl pathway reversed the repressive role of xist in cell osteogenic differentiation.All in all, these findings suggest that xist knockdown induces the differentiation of osteoblast-like cells via regulation of the mi r-135/creb1/tnf-α/rankl axis.Xist, as a consequence, represents an attractive therapeutic strategy to accelerate fracture healing.

Journal: Human cell (2022)
Publication types: Journal Article