syedzayyan/paper_mill_benchmark huggingface dataset:
Meta-Analysis of Anesthetic Efficacy and Safety of Propofol in Craniotomy Patients

The anesthetic effect and safety of propofol in craniotomy patients by meta‐analysis is investigated.Relevant studies consistent with the anesthetic effect and safety of propofol in craniotomy patients are searched and screened from domestic and foreign literature databases such as wanfang medical center, cnki, vip, and pub med, and meta‐analysis is performed by rev man 5.2 software.Experimental results show that the recovery time, intracranial pressure, cerebral edema, partial cerebral oxygen pressure, glutamate, and mda in the propofol group are better than those in the control group ( p &lt; 0.05), and the incidence of superoxide dismutase, tnf‐ α , and adr in the propofol group is better than that in the control group ( p &gt; 0.05).Intravenous anesthesia with propofol in patients with craniotomy has the advantage of rapid recovery, and this program can improve intracranial pressure, brain edema, and brain oxygen partial pressure and help to improve oxidative stress and inflammatory reaction.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Meta-Analysis;
lncRNA NBAT1 Inhibits Cell Metastasis and Promotes Apoptosis in Endometrial Cancer by Sponging miR-21-5p to Regulate PTEN

Long noncoding rna neuroblastoma-associated transcript 1 (nbat1) is implicated in the progression of various cancers.Nevertheless, its biological function in endometrial cancer (ec) remains unknown.Methods.The levels of nbat1, mi r-21-5p, and pten in ec cells and ec tissues were examined by rt-q pcr.Western blot was carried out to assess the protein expression of pten.The dual-luciferase reporter assay was conducted to explore the interactions among nbat1, mi r-21-5p, and pten.The effect of nbat1 on ec proliferation, metastasis, and apoptosis was evaluated by cck-8, transwell assays, wound healing, and flow cytometry.Mi r-21-5p mimics or nbat1+mi r-21-5p were transfected into hec-1a and ishikawa cells to investigate whether nbat1 regulated ec tumorigenesis via sponging mi r-21-5p.Results.Nbat1 is downregulated, and mi r-21-5p is upregulated in ec cells and tumor tissues.Overexpression of nbat1 inhibits the proliferation, migration, and invasion abilities of ec cells and facilitated apoptosis.Nbat1 directly binds and negatively regulates mi r-21-5p in ec.Mi r-21-5p mimics reverses the effect of lnc rna nbat1 overexpression on the proliferation and migration of ec cells.Pten is a downstream gene of mi r-21-5p.Lnc rna nbta1 elevates pten expression via sponging mi r-21-5p.Conclusions.Lnc rna nbat1 acts as a tumor suppressor in ec via regulating pten through sponging mi r-21-5p.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Knockdown of lncRNA FOXD2-AS1 Inhibits Proliferation, Migration, and Drug Resistance of Breast Cancer Cells

In order to investigate the effect of lnc rna foxd2-as1 on breast cancer cells proliferation, migration, and drug resistance as well as its molecular mechanism.Methods.Real-time pcr was used to detect the expression of breast cancer tissues and cells from patients admitted to our hospital and the expression of lnc rna foxd2-as1 in mcf-7/adr in adriamycin- (adr-) resistant breast cancer cells.After interfering with or overexpressing lnc rna foxd2-as1 in mcf-7/adr cells, cell proliferation, apoptosis, invasion, and migration were detected using cck-8, flow cytometry, transwell assay, and scratch test, respectively.The protein levels of pi3k, p-pi3k, akt, and p-akt in the pi3k/akt signaling pathway were detected by western blot.Results.Lnc rna foxd2-as1 was upregulated in breast cancer tissues and cells and increased cell drug resistance to adr.Downregulation of lnc rna foxd2-as1 inhibited invasion and migration of mcf-7/adr cells, promoted apoptosis, increased chemosensitivity of mcf-7/adr cells, and inhibited the activity of pi3k/akt signaling pathway in mcf-7/adr cells.Conclusions.Lnc rna foxd2-as1 can promote the proliferation, invasion, migration, and drug resistance of breast cancer cells, inhibit apoptosis, and accelerate the development of breast cancer by positively regulating the pi3k/akt signaling pathway.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
TTC7B Is a Novel Prognostic-Related Biomarker in Glioma Correlating with Immune Infiltrates and Response to Oxidative Stress by Temozolomide

Gliomas are one of the most prevalent malignant brain tumors.Hence, identifying biological markers for glioma is imperative.Ttc7b (tetratricopeptide repeat domain 7b) is a gene whose role in cancer in currently identified.To this end, we examined the ttc7b expression as well as its prognostic significance, biological roles, and immune system impacts in patients with glioma.Methods.We evaluated the function of ttc7b in gbm and lgg through the published cgga (chinese glioma genome atlas) and tcga (the cancer genome atlas) databases.Cibersort and timer were used to analyze the link between ttc7b and immune cells, while r was used for statistical analysis.In addition, transwell analysis, including migration and invasion assays, was performed to identify the relationship between ttc7b and temozolomide.Results.Low expression of ttc7b was observed in gbm and lgg.1p/19q codeletion, idh mutation, chemotherapy, and grade were found to have a significant correlation with ttc7b.Besides, low ttc7b expression was linked with low overall survival (os) in both gbm and lgg.In the cox analysis, ttc7b was found to independently function as a risk element for os of patients with glioma.Furthermore, cibersort analysis demonstrated a positive link between ttc7b and multiple immune cells, especially activated nk cells.Transwell analysis, including migration and invasion assays, revealed that temozolomide reduced the migration and invasion capacity of glioma cells and increased the expression of ttc7b.Conclusion.In all, ttc7b could serve as a promising prognostic indicator of lgg and gbm, and is closely associated with immune infiltration and response to oxidative stress by temozolomide.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Investigation of the Clinical Efficacy of Acupuncture Combined with Traditional Chinese Medicine Fumigation in the Treatment of Rheumatoid Arthritis by Meta-Analysis

In order to investigate the clinical efficacy of acupuncture combined with traditional chinese medicine fumigation in the treatment of rheumatoid arthritis (ra) by meta‐analysis, literature related to the treatment of rheumatoid arthritis by acupuncture combined with traditional chinese medicine fumigation are searched in line with the research direction.Meta‐analysis is conducted by rev man 5.2 software.A total of 17 literature are included and the publication bias of the included literature is low.The experimental results show that acupuncture combined with traditional chinese medicine fumigation can reduce the inflammatory response and clinical symptoms of ra patients, and the addition of acupuncture can improve the clinical efficacy, which has a certain feasibility of promotion.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Meta-Analysis;
Influence and Effect of Acupoint Application of Chinese Medicine on Height and Bone Age of Children with Short Stature

To explore the effect of acupoint application of chinese medicine on children’s height and bone age.Methods.Altogether, 120 children with a short stature treated in our hospital from september 2017 to september 2018 were divided into the control group (cg, n = 60) and the observation group (og, n = 60) according to the random number table method.The children in cg were given healthy diet and exercise plans and supplemented with daily vitamin intake.The og was treated with acupoint application of chinese medicine on the basis of the cg.The clinical efficacy of the cg and the og of children after treatment was observed.The height increment, growth rate, and bone age of children were compared before and after treatment.The levels of igf-1 and 25-(oh)d in the serum of children before and after treatment were tested.According to the clinical curative effect after treatment, the children were divided into good curative effect group (markedly effective + effective) and poor curative effect group (ineffective).Logistics regression analysis was applied to analyze the risk factors.Results.Compared with the cg, the curative effect on the og was evidently improved ( p &lt; 0.05 ).In addition, the height increment, the growth speed, and the bone age of the og increased evidently ( p &lt; 0.05 ).Compared with the cg, the expression of igf-1 and 25-(oh)d of the og elevated ( p &lt; 0.05 ).Serum igf-1 and 25-(oh)d concentrations were positively correlated with growth rate and bone age ( p &lt; 0.05 ).Risk factors analysis showed that disease course, igf-1, 25-(oh)d expression, and heredity were the risk factors affecting the curative effect on children.Conclusion.Acupoint application of chinese medicine has effect on the height and bone age of children with short stature, which is worthy of clinical promotion.In addition, early treatment should be carried out to improve the clinical efficacy of children.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Research Article;
Identification and Classification of Prostate Cancer Identification and Classification Based on Improved Convolution Neural Network

Prostate cancer is one of the most common cancers in men worldwide, second only to lung cancer.The most common method used in diagnosing prostate cancer is the microscopic observation of stained biopsies by a pathologist and the gleason score of the tissue microarray images.However, scoring prostate cancer tissue microarrays by pathologists using gleason mode under many tissue microarray images is time‐consuming, susceptible to subjective factors between different observers, and has low reproducibility.We have used the two most common technologies, deep learning, and computer vision, in this research, as the development of deep learning and computer vision has made pathology computer‐aided diagnosis systems more objective and repeatable.Furthermore, the u‐net network, which is used in our study, is the most extensively used network in medical image segmentation.Unlike the classifiers used in previous studies, a region segmentation model based on an improved u‐net network is proposed in our research, which fuses deep and shallow layers through densely connected blocks.At the same time, the features of each scale are supervised.As an outcome of the research, the network parameters can be reduced, the computational efficiency can be improved, and the method’s effectiveness is verified on a fully annotated dataset.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Hyperspectral Image Analysis of Colon Tissue and Deep Learning for Characterization of Health care

Colon cancer is a disease characterized by the unusual and uncontrolled development of cells that are found in the large intestine.If the tumour extends to the lower part of the colon (rectum), the cancer may be colorectal.Medical imaging is the denomination of methods used to create visual representations of the human body for clinical analysis, such as diagnosing, monitoring, and treating medical conditions.In this research, a computational proposal is presented to aid the diagnosis of colon cancer, which consists of using hyperspectral images obtained from slides with biopsy samples of colon tissue in paraffin, characterizing pixels so that, afterwards, imaging techniques can be applied.Using computer graphics augmenting conventional histological deep learning architecture, it can classify pixels in hyperspectral images as cancerous, inflammatory, or healthy.It is possible to find connections between histochemical characteristics and the absorbance of tissue under various conditions using infrared photons at various frequencies in hyperspectral imaging (hsi).Deep learning techniques were used to construct and implement a predictor to detect anomalies, as well as to develop a computer interface to assist pathologists in the diagnosis of colon cancer.An infrared absorbance spectrum of each of the pixels used in the developed classifier resulted in an accuracy level of 94% for these three classes.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
Ginkgolide A Participates in LPS-Induced PMVEC Injury by Regulating miR-224 and Inhibiting p21 in a Targeted Manner

Most studies have focused on the protective effects of ginkgolide a against ischemia/reperfusion‐induced cardiomyopathy and injury of the brain, liver, and other organs, but there are few reports about the protection of lung tissues.This study was designed to clarify the protection of ginkgolide a against lipopolysaccharide (lps)‐induced pulmonary microvascular endothelial cell (pmvec) injury.Pmvecs were extracted and fell into control, lps, and ginkgolide a groups.Next, we delved into the growth activity and apoptosis rate of cells via the cck‐8 assay and hoechst staining, independently.Beyond that, western blotting (wb) was implemented for measurement of the expressions of cyclin d1, cyclin‐dependent kinase 4 (cdk4), and cdk inhibitor (p21) that pertained to the cell cycle.The target sites of ginkgolide a were confirmed by mi rna array and real‐time quantitative pcr.The relationship between mi r‐224 and p21 was analyzed using dual‐luciferase reporter gene assay.Compared with the control group, the lps group and ginkgolide a group had significantly decreased cell growth activity and relative expressions of cyclin d1 and cdk4 and elevated apoptosis rate and p21 expression.Pronounced elevations were observable in the cell growth activity and expressions of cyclin d1, cdk4, and p21, while the ginkgolide a group presented with a reduced apoptosis rate in comparison with the lps group ( p &lt; 0.05).Mi r‐224 was the target of ginkgolide a, which had targeted regulatory effects on p21.Ginkgolide a can modulate mi r‐224 expression and regulate p21 expression in a targeted manner to enhance the resistance of pmvecs to lps‐induced cell apoptosis.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Gastrocnemius Muscle Injury Is the Condition to Induce Cartilage Degeneration of the Rabbit Tibiofemoral Joint: A New Perspective

The knee osteoarthritis is a common joint disease that causes pain and inconvenience.Clinically, patients with knee osteoarthritis often have response points on the gastrocnemius.Gastrocnemius plays an essential role in stabilizing joints and changing gait and pace, which also has a close relationship with the knee joint.The objective of this study is to determine changes in the tibiofemoral joint after medial and lateral gastrocnemius injury.Rabbits were divided into a medial gastrocnemius injury group, a lateral gastrocnemius injury group, and a control group with two intervals: 6 and 8 weeks after modeling of the semisevered gastrocnemius.The gastrocnemius was weighed and sectioned for histology.The joint space and subchondral bone were observed using x‐ray and microcomputed tomography.The cartilage was observed histologically using safranin o fast green and masson and immunohistochemically using antibodies to collagen type ii, matrix metalloproteinase 13, and integrin beta1.Results showed muscle fiber atrophy, and fibrotic changes occurred after gastrocnemius semidissociation.After gastrocnemius injury, the femoral condyle of the tibiofemoral joint produced abnormal sclerosis and bone degeneration.The pathological changes of cartilage included disordered or reduced cell alignment, cartilage matrix loss, and collagen loss due to decreased collagen type ii and increased matrix metalloproteinase 13 activity.The increase of integrin beta1 in the injured group may be related to mechanical conduction process.The results suggest that gastrocnemius injury is an essential factor in tibiofemoral arthritis.

Journal: BioMed Research International (2022)
Publication types: Research Article;
FAM87A as a Competing Endogenous RNA of miR-424-5p Suppresses Glioma Progression by Regulating PPM1H

Far less has been unveiled about the functions of lnc rnas on cancers yet.Here, we reported that lnc rna fam87a, as a ce rna of mi r-424-5p, played a vital role in glioma development.Q rt-pcr result indicated that fam87a was abnormally downregulated in glioma tissue and cells.Survival analysis suggested that the fam87a expression was negatively correlated with the survival rate.Effects of fam87a on human glioma cell lines were also analyzed by mtt, edu, and transwell assays.Fam87a hastened proliferation and migration of glioma cells.Mi r-424-5p, predicted target of fam87a, was fostered in glioma, which was examined by q rt-pcr.A negative correlation was indicated between fam87a and mi r-424-5p.Results of bioinformatics, dual luciferase, and rip assays unveiled that fam87a and mi r-424-5p act upon each other.In addition, mi r-424-5p targeted 3 ′ -utr of ppm1h.Also, effects of mi r-424-5p/fam87a on glioma cells were identified via the cell function experiments.Fam87a suppressed ppm1h by binding to mi r-424-5p competitively, thereby restraining cell proliferation, migration, and invasion.Collectively, these findings illuminated a new mechanism for glioma progression.Therefore, fam87a may act as a feasible target for glioma treatment.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
Efficacy of Shuanghe Jiyu Decoction in 126 Patients with Bone Marrow Suppression

Bone marrow suppression is a common complication of chemotherapy.In order to observe the effects of shuanghe jiyu decoction on peripheral white blood cells (wbc), hemoglobin (hb), and platelet (plt) in patients with bone marrow suppression, a total of 126 patients with bone marrow suppression were given at least three consecutive cycles of chemotherapy.The results show that among 126 patients with bone marrow suppression, 16 achieved marked efficacy and 100 achieved moderate efficacy.The overall effective rate is 92.06%.Moreover, the symptoms of bone marrow suppression are mitigated.No adverse events are reported during the treatment.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Efficacy of Respiratory Training in Relieving Postoperative Pain in Patients with Spinal Nerve Root Entrapment Syndrome

Breathing exercise can help patients with dyspnea to change the wrong breathing pattern, improve the degree of freedom of respiratory muscles, increase alveolar ventilation, promote breathing, and relieve the symptoms of dyspnea patients.Therefore, this study is aimed at investigating the role of breathing training in alleviating postoperative pain in patients with spinal nerve root entrapment syndrome.Objective.To explore the effect of respiratory training in relieving postoperative pain in patients with spinal nerve root entrapment syndrome.Methods.Fifty-eight patients with spinal nerve root entrapment syndrome treated in our hospital from may 2020 to may 2021 were analyzed retrospectively.The patients were randomly divided into a control group ( n = 29 ) and an observation group ( n = 29 ).The control group was given routine postoperative pain nursing, and the observation group was given respiratory training on the basis of the control group.The scores of visual analogue scale (vas), self-rating anxiety scale (sas), oswestry dysfunction index questionnaire (odi), the dosage of postoperative analgesics, and the time of first out-of-bed activity were recorded before pain nursing intervention and 3 days and 7 days after intervention.Results.The vas, sas, and odi scores of the observation group after 3 d and 7 d of intervention were lower than those of the control group.Compared with the same group, the scores of vas, sas, and odi after 3 d and 7 d of intervention were lower than those before intervention, and those after 7 d of intervention were lower than those after 3 d of intervention ( p &lt; 0.05 ).The dosage of postoperative analgesics and the time of first out-of-bed activity in the observation group were lower than those in the control group ( p &lt; 0.05 ).Conclusion.Respiratory training can effectively relieve postoperative pain, reduce anxiety, and improve spinal function in patients with spinal nerve root entrapment syndrome, which is beneficial to the prognosis of patients and is worthy of promotion.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Efficacy of Posterior Cervical Laminectomy and Decompression plus Lateral Mass Screw-Rod Internal Fixation in the Treatment of Multisegment Cervical Spinal Canal Stenosis and Effects on Cervical Curvature and Range of Motion Parameters

To investigate the clinical effects of posterior laminectomy and decompression plus lateral mass screw-rod internal fixation for the treatment of multisegment cervical spinal canal stenosis and the improvement of cervical curvature and range of motion in patients.Methods.A total of 68 patients with multisegment cervical spinal stenosis who were treated in our hospital from january 2019 to june 2020 were selected and randomly divided into the control group and the observation group according to the random number table, with 34 patients in each group.The patients in the control group were treated with traditional posterior cervical open-door laminoplasty with silk suture fixation, while those in the observation group were treated with posterior cervical laminectomy and decompression plus lateral mass screw-rod internal fixation.The perioperative index of patients in the two groups was recorded, and the clinical efficacy of patients was evaluated.The patient’s joa score, cervical physiological curvature, and cervical range of motion were evaluated.The occurrence of complications was recorded during follow-up.Results.The amount of intraoperative bleeding and postoperative rehabilitation training time in the observation group was less than that in the control group ( p &lt; 0.05 ).There was no significant difference in operation time between the two groups ( p &gt; 0.05 ).The total effective rate of the observation group was significantly higher than that of the control group ( p &lt; 0.05 ).The joa scores at 1 week, 6 months, and 12 months after operation in the observation group were higher than those in the control group ( p &lt; 0.05 ).The physiological curvature of cervical spine in the observation group at 1 week, 6 months, and 12 months after operation was higher than that in the control group ( p &lt; 0.05 ).The cervical range of motion at 12 months after operation in the observation group was significantly higher than that in the control group ( p &lt; 0.05 ).The incidence of postoperative complications in patients of the observation group was significantly lower than that of the control group ( p &lt; 0.05 ).Conclusion.Posterior laminectomy and decompression plus lateral mass screw-rod internal fixation can help patients to improve various clinical symptoms caused by nerve compression and obtain better improvement of cervical curvature and range of motion.It is an ideal surgical method for the treatment of multisegment cervical spinal canal stenosis, and it is conducive to improving the clinical efficacy of patients.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Clinical Study;