syedzayyan/paper_mill_benchmark huggingface dataset:
Interrogating Light-initiated Dynamics in Metal-Organic Frameworks with Time-resolved Spectroscopy.

Time-resolved spectroscopy is an essential part of both fundamental and applied chemical research.Such techniques access light-initiated dynamics on time scales ranging from femtosecond to microsecond.Many techniques falling under this description have been applied to gain significant insight into metal-organic frameworks (mofs), a diverse class of porous coordination polymers.Mofs are highly tunable, both compositionally and structurally, and unique challenges are encountered in applying time-resolved spectroscopy to interrogate their light-initiated properties.These properties involve various excited state mechanisms such as crystallographically defined energy transfer, charge transfer, and localization within the framework, photoconductivity, and structural dynamics.The field of time-resolved mof spectroscopic studies is quite nascent; each original report cited in this review was published within the past decade.As such, this review is a timely and comprehensive summary of the most significant contributions in this emerging field, with focuses on the overarching spectroscopic concepts applied and on identifying key challenges and future outlooks moving forward.

Journal: Chemical reviews (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.;Review
Long noncoding RNA KB-1460A1.5 inhibits glioma tumorigenesis via miR-130a-3p/TSC1/mTOR/YY1 feedback loop.

Long noncoding rnas (lnc rnas) have been shown to be closely related to cancer progression and therapy.However, the clinical significance of lnc rnas and the mechanisms by which they function in glioma are largely unknown.In this study, using online data sets combined with collected clinical glioma tissues, we determined that the lnc rna kb-1460a1.5 is downregulated and positively correlated with prognosis in glioma.Functional experiments showed that overexpression of kb-1460a1.5 inhibits glioma cell proliferation, migration and invasion in vitro and in vivo, while downregulation of kb-1460a1.5 has the opposite effects.Mechanistically, tandem mass tag (tmt)-based quantitative proteomic analysis revealed that kb-1460a1.5 preferentially affects the akt/tsc1/m tor pathway.Kb-1460a1.5 was found to function as a competing endogenous rna (ce rna) to regulate the expression of tsc1, a key regulatory component of the m tor pathway, by sponging mi r-130a-3p in glioma cells.Furthermore, our data demonstrate that the m tor pathway regulates the expression of the transcription factor yin yang 1 (yy1), which in turn binds directly to the kb-1460a1.5 promoter and affects the expression of kb-1460a1.5.Untargeted metabolomics and quantitative real-time pcr (q rt-pcr) analysis further confirmed the effects of kb-1460a1.5 on amino acid metabolism.In conclusion, this study revealed that lnc rna kb-1460a1.5 inhibits glioma tumorigenesis via mi r-130a-3p/tsc1/m tor/yy1 feedback loop.

Journal: Cancer letters (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A Differentiable Dynamic Model for Musculoskeletal Simulation and Exoskeleton Control.

An exoskeleton, a wearable device, was designed based on the user's physical and cognitive interactions.The control of the exoskeleton uses biomedical signals reflecting the user intention as input, and its algorithm is calculated as an output to make the movement smooth.However, the process of transforming the input of biomedical signals, such as electromyography (emg), into the output of adjusting the torque and angle of the exoskeleton is limited by a finite time lag and precision of trajectory prediction, which result in a mismatch between the subject and exoskeleton.Here, we propose an emg-based single-joint exoskeleton system by merging a differentiable continuous system with a dynamic musculoskeletal model.The parameters of each muscle contraction were calculated and applied to the rigid exoskeleton system to predict the precise trajectory.The results revealed accurate torque and angle prediction for the knee exoskeleton and good performance of assistance during movement.Our method outperformed other models regarding the rate of convergence and execution time.In conclusion, a differentiable continuous system merged with a dynamic musculoskeletal model supported the effective and accurate performance of an exoskeleton controlled by emg signals.

Journal: Biosensors (2022)
Publication types: Journal Article
Trends in Management and Mortality in Adults Hospitalized With Cardiac Arrest in the United States.

We sought to examine temporal trends in management (ie, use of extracorporeal membrane oxygenation [ecmo], therapeutic hypothermia [th], coronary angiogram, and percutaneous coronary intervention [pci]) and in-hospital mortality in adults hospitalized with cardiac arrest.Methods utilizing the nationwide inpatient sample, medical history, clinical management, and in-hospital mortality were assessed in 942 495 hospitalizations in adults with cardiac arrest (identified through international classification of diseases-9codes) from 2006 to 2012.Results from 2006 to 2012, there was an overall rise in the use of coronary angiogram (12.8%, 13.0%, 14.7%, 15.0%, 14.3%, 14.7%, and 15.8%), pci (7.5%, 7.1%, 8.4%, 8.1%, 8.1%, 8.4%, and 8.9%), th (0.2%, 0.3%, 0.6%, 1.2%, 1.9%, 2.8%, and 3.0%), and ecmo (0.1%, 0.1%, 0.1%, 0.2%, 0.2%, 0.3%, and 0.4%;p< .001 for all).In-hospital mortality significantly decreased over the 7-year study period (65.5%, 63.4%, 59.3%, 57.9%, 57.0%, 56.0%, and 56.3% from 2006 to 2012).In multivariable analysis, a 31% decrease in mortality was accompanied by a concomitant 24% and 27% increase in coronary angiogram and pci, respectively, during the study period.Therapeutic hypothermia and ecmo were associated with an approximate 11-fold and 7-fold increase, respectively, from 2006 to 2012.The strongest predictors of use of ecmo, th, coronary angiogram, and pci were younger age and the presence of coronary artery disease.Conclusion during 2006 to 2012, a decline in mortality was accompanied by a steady rise in the use of ecmo, th, coronary angiogram, and pci in adults hospitalized with cardiac arrest.Patients of younger age and with coronary artery disease were more likely to receive these advanced therapies.

Journal: Journal of intensive care medicine (2019)
Publication types: Journal Article
Association of genetic polymorphisms with local steroid metabolism in human benign breasts.

Although alterations of concentrations in circulating steroids have been linked to single nucleotide polymorphisms (snps) of steroidogenic enzymes, we hypothesized that snps of such enzymes located within the breast affect local steroid concentrations more than products of such snps absorbed from the circulation.Methods steroids (estradiol, estrone, testosterone, androstenedione, dhea, dhea sulfate, progesterone) in nipple aspirate fluid (naf) were purified by hplc and they along with serum steroids were quantified by immunoassays.Polymorphisms of the transporter slco2b1 and enzymes hsd3b1, cyp19a1, hsd17b12, akr1c3, cyp1b1, and srd5a1 were measured in white blood cell dna.Results steroid concentrations in naf of subjects with homozygous minor genotypes differed from those with heterozygotes, i.e., slco2b1 (rs2851069) decreased dheas (p = 0.04), hsd17b12 (rs11555762) increased estradiol (p < 0.004), and cyp1b1 (rs1056836) decreased estradiol (p = 0.017) and increased progesterone (p = 0.05).Also, in serum, cyp19a1 (rs10046 and rs700518) both decreased testosterone (p = 0.02) and srd5a1 increased androstenedione (p = 0.006).Steroids in subjects with major homozygotes did not differ from those with heterozygotes indicating recessive characteristics.Conclusions in the breast, snps were associated with decreased uptake of dheas (slco2b1), increased estradiol concentrations through increased oxidoreductase activity (hsd17b12), or decreased estradiol concentrations by presumed formation of 4-hydroxyestradiol (cyp1b1).Cyp19a1 was associated with decreased testosterone concentrations in serum but had no significant effect on estrogen or androgen concentrations within the breast.The hormone differences observed in naf were not usually evident in serum, indicating the importance of assessing the effect of these snps within the breast.

Journal: Steroids (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Immature Vascular Smooth Muscle Cells in Healthy Murine Arteries and Atherosclerotic Plaques: Localization and Activity.

The local development of atherosclerotic lesions may, at least partly, be associated with the specific cellular composition of atherosclerosis-prone regions.Previously, it was demonstrated that a small population of immature vascular smooth muscle cells (vsmcs) expressing both cd146 and neuron-glial antigen 2 is postnatally sustained in atherosclerosis-prone sites.We supposed that these cells may be involved in atherogenesis and can continuously respond to angiotensin ii, which is an atherogenic factor.Using immunohistochemistry, flow cytometry, wound migration assay x celligence system, and calcium imaging, we studied the functional activities of immature vsmcs in vitro and in vivo.According to our data, these cells do not express nestin, cd105, and the leptin receptor.They are localized in atherosclerosis-prone regions, and their number increases with age, from 5.7% to 23%.Immature vsmcs do not migrate to low shear stress areas and atherosclerotic lesions.They also do not have any unique response to angiotensin ii.Thus, despite the localization of immature vsmcs and the presence of the link between their number and age, our study did not support the hypothesis that immature vsmcs are directly involved in the formation of atherosclerotic lesions.Additional lineage tracing studies can clarify the fate of these cells during atherogenesis.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article
Oil-gelling properties of soy lecithin fractions.

Lecithin is a mixture of amphiphilic lipids with health benefits.In this study, four different fractions (ethanol soluble, ethanol insoluble, phospholipid and glycolipid fractions) from soy lecithin were obtained and evaluated as oleogelators.As with the parent lecithin, the ethanol insoluble fraction (eif) was unable to function as an oleogelator.The ethanol soluble fraction (esf) and phospholipid fraction (plf) formed oleogels at 30% (wt%), while the glycolipid fraction (glf) formed oleogels at 15%.Esf resulted in an oleogel with a similar appearance and microstructure, but a harder and less cohesive texture than the plf-supported oleogel.The oleogels formed with glf were different from those formed with esf and plf in appearance and microstructure.Glf at 20% formed an oleogel with better texture characteristics (in the light of hardness) and oil-holding capacity than those formed with 30% of esf and plf.This is the first study to investigate the oil-gelling properties of fractions from soy lecithin.Our results show that the naturally occurring glycolipids from soy lecithin exhibit great potential as oleogelators.

Journal: Food & function (2021)
Publication types: Journal Article
Hematologic Complications Associated With Intra-arterial Chemotherapy for Retinoblastoma Treatment: A Single Institution Experience.

Retinoblastoma (rb) is the most common intraocular pediatric malignancy.Advancements in intra-arterial chemotherapy (iac) for treatment of rb have resulted in dramatic improvement in eye salvage rates.Data regarding iac outcomes and associated hematologic toxicities are limited.The objective of this retrospective study was to analyze baseline characteristics, efficacy, and hematologic complications associated with iac treatment in children with rb at a single international referral institution.Ninety-five sessions of iac were performed in 28 patients.Mean age at rb diagnosis was 12.5 months (sd, 9.2 mo).Fourteen patients had bilateral rb.Iac agents included melphalan, carboplatin, and topotecan.The most common regimens were triple-agent iac and single-agent melphalan (66.3% and 15.8%, respectively).Median number of iac sessions was 3 (mean: 3.39, range: 1 to 9).Eye salvage rate was 83.7% with an overall survival rate of 100% at a median follow-up of 29 months (mean: 29.8 mo, range: 1 to 63 mo).A total of 26 patients (92.9%) experienced at least 1 hematologic toxicity during their treatment course prevalence of neutropenia, anemia, and thrombocytopenia were 89.3%, 85.7%, and 25%, respectively.While iac is effective in salvaging most eyes with advanced intraocular rb, over half of patients experienced clinically significant neutropenia and anemia.Clinicians should be vigilant in monitoring patients for iac-related complications.

Journal: Journal of pediatric hematology/oncology (2022)
Publication types: Journal Article
Ventricular-Vascular Uncoupling in Heart Failure: Effects of Arterial Baroreflex-Induced Sympathoexcitation at Rest and During Exercise.

Autonomic alterations in blood pressure are primarily a result of arterial baroreflex modulation of systemic vascular resistance and cardiac output on a beat-by-beat basis.The combined central and peripheral control by the baroreflex likely acts to maintain efficient energy transfer from the heart to the systemic vasculature; termed ventricular-vascular coupling.This level of control is maintained whether at rest or during exercise in healthy subjects.During heart failure, the ventricular-vascular relationship is uncoupled and baroreflex dysfunction is apparent.We investigated if baroreflex dysfunction in heart failure exacerbated ventricular-vascular uncoupling at rest, and during exercise in response to baroreceptor unloading by performing bilateral carotid occlusions in chronically instrumented conscious canines.We observed in healthy subjects that baroreceptor unloading caused significant increases in effective arterial elastance (ea) at rest (1.2 ± 0.3 mm hg/ml) and during exercise (1.3 ± 0.2 mm hg/ml) that coincided with significant increases in stroke work (sw) (1.5 ± 0.2 mm hg/ml) and (1.6 ± 0.2 mm hg/ml) suggesting maintained ventricular-vascular coupling.Heart failure significantly increased the effect of baroreceptor unloading on ea at rest (3.1 ± 0.7 mm hg/ml) and during exercise (2.3 ± 0.5 mm hg/ml) whereas no significant increases in stroke work occurred, thus signifying further ventricular-vascular uncoupling.We believe that the enhanced ventricular-vascular uncoupling observed during baroreceptor unloading only worsens the already challenged orthostatic and exercise tolerance and thereby contributes to poor exercise performance and quality of life for heart failure patients.

Journal: Frontiers in physiology (2022)
Publication types: Journal Article
Synthesis and Biological Evaluation of Umifenovir Analogues as Anti-SARS-CoV-2 Agents.

The unprecedented novel coronavirus disease 2019 (covid-19) pandemic is a threat to global health and the economy.Since the outbreak of covid-19, great effort has been made to reposition existing drugs to shorten development timelines, in addition to vaccine development and drug discovery campaigns.Umifenovir is a broad-spectrum antiviral agent used to treat influenza in china and russia and is currently undergoing clinical trials for the treatment of covid-19.In this article, the synthesis of umifenovir analogues and their biological evaluation are reported.The inhibitory activities of analogues against the binding of the spike glycoprotein (s-protein) of the novel severe acute respiratory syndrome coronavirus-2 (sars-co v-2) to the ace2 receptor, which is a possible mode of action for umifenovir to inhibit viral infection, were investigated.

Journal: ChemistrySelect (2022)
Publication types: Journal Article
Underlying selection for the diversity of spike protein sequences of SARS-CoV-2.

The global spread of sars-co v-2 is fast moving and has caused a worldwide public health crisis.In the present article, we analyzed spike protein sequences of sars-co v-2 genomes to assess the impact of mutational diversity.We observed from amino acid usage patterns that spike proteins are associated with a diversity of mutational changes and most important underlying cause of variation of amino acid usage is the changes in hydrophobicity of spike proteins.The changing patterns of hydrophobicity of spike proteins over time and its influence on the receptor binding affinity provides crucial information on the sars-co v-2 interaction with human receptor.Our results also show that spike proteins have evolved to prefer more hydrophobic residues over time.The present study provides a comprehensive analysis of molecular sequence data to consider that mutational variants might play a crucial role in modulating the virulence and spread of the virus and has immediate implications for therapeutic strategies.

Journal: IUBMB life (2022)
Publication types: Journal Article
Young people and parents' views towards individual cognitive remediation therapy-qualitative findings from a feasibility randomised controlled trial.

Cognitive remediation therapy (crt) has been used mostly in adults.Randomised controlled trials (rcts) in anorexia nervosa (an) have shown that crt enhances cognitive flexibility, abstract thinking and is associated with quality-of-life improvement.More research is needed in younger populations.Methods a single-centre feasibility rct with young people (yp) with an was conducted in an inpatient setting.A secondary aim of this study was to explore patient satisfaction and parents' views towards crt to inform further development and implementation of crt in yp.Yp were asked to complete a therapy feedback questionnaire and write a letter with their views on crt.Parents were asked to complete a questionnaire exploring their perceptions of crt.Data were analysed using inductive thematic and deductive content analysis.Results both yp and parents valued crt.Its engaging and pragmatic nature and its focus on thinking styles were perceived as a novel aspect.Parents expressed the need to be involved in the sessions to be able to continue to support their children at home.Conclusions this study confirms previous qualitative findings.Should a fully powered rct be conducted, it would be important to take into account these findings to further adapt the content of the crt sessions to the yp needs and to consider their parents' involvement in the sessions, which could also increase the likelihood of parents' engagement in providing their feedback.Level of evidence level i: evidence obtained from one randomized controlled trial.

Journal: Eating and weight disorders : EWD (2022)
Publication types: Journal Article
Black phosphorous/palladium functionalized carbon aerogel nanocomposite for highly efficient ethanol electrooxidation.

Direct ethanol fuel cells have great potential for practical power applications due to their easy operation, high energy density, and low toxicity.However, the slow and incomplete ethanol electrooxidation (eeo) reaction is a major drawback that hinders the development of this type of fuel cell.Here, we report a facile approach for the preparation of highly active, low cost and stable electrocatalysts based on palladium (pd) nanoparticles and black phosphorus/palladium (bp/pd) nanohybrids supported on a carbon aerogel (ca).The nanocomposites show remarkable catalytic performance and stability as anode electrocatalysts for eeo in an alkaline medium.A mass peak current density of 8376 m a mg pd-1is attained for eeo on the bp/pd/ca catalyst, which is 11.4 times higher than that of the commercial pd/c catalyst.To gain deep insight into the structure-property relationship associated with superior electroactivity, the catalysts are well characterized in terms of morphology, surface chemistry, and catalytic activity.It is found that the bp-doped ca support provides high catalyst dispersibility, protection against leaching, and modification of the electronic and catalytic properties of pd, while the catalyst modifies ca into a more open and conductive structure.This synergistic interaction between the support and the catalyst improves the transport of active species and electrons at the electrode/electrolyte interface, leading to rapid eeo reaction kinetics.

Journal: RSC advances (2022)
Publication types: Journal Article
Equilibrium and thermodynamic investigation of biosorption of nickel from water by activated carbon made from palm kernel chaff.

Novel biosorbents were derived from a waste product of palm kernel oil extraction known as palm kernel chaff (pkc).One portion of the pkc was carbonized in a furnace and then activated chemically, while the other half was activated without carbonization.Both were designated as cpkc and upkc, respectively.The two biosorbents so produced were then used to conduct batch equilibrium and kinetic sorption studies at 30 °c, 35 °c and 40 °c and p h 3.0 and 9.0 for an agitation period of 5, 10, 20, 40, 60, 90, and 120 min.The koble-corrigan, dubinin-radushkevich, and the freundlich isotherms fitted the experimental data very well with r2values of 0.97 to 1.0, 0.95 to 1.0, and 0.96 to 1.0, respectively.The linear type ii langmuir isotherm performed much better (0.96 ≤ r2≤ 1.0) than the nonlinear isotherm.The maximum sorption capacity was obtained as 120.6 mg/g using cpkc at p h 9.0 and 35 °c.The langmuir separation coefficient values (0.022 ≤ rl≤ 0.926) show that the sorption of nickel to pkc is favorable.The most favorable sorption condition was found for cpkc at p h 9 and temperature of 40 °c.The values of sorption energy (8.21 ≤ e ≤ 14.27) and the isosteric heat of sorption (-133.09 ≤ ∆hx≤ -17.92) indicate that the mode of sorption is mostly ion exchange.Thermodynamic parameters also show that the process is exothermic and entropy-driven.The pseudo-second-order kinetic model shows the best correlation compared to the other kinetic models.The coefficient of correlation for the pseudo-second-order model was mostly within the range of 0.999-1.000 for 90% of all kinetic studies carried out.

Journal: Scientific reports (2021)
Publication types: Journal Article
A vacuum-annealing strategy for improving near-infrared super long persistent luminescence in Cr(3+) doped zinc gallogermanate nanoparticles for bio-imaging.

Novel cr(3+) doped zinc gallogermanate (zggo) nanoparticles with 697 nm near-infrared (nir) super long afterglow were prepared via a hydrothermal method.Subsequently, a vacuum-annealing strategy was adopted to improve nir afterglow in zggo:cr(3+) nanoparticles.For the sample annealed at 800 °c, no variation in the particle size is observed, the persistent luminescence increases by an order of magnitude (∼14 times) and the nir afterglow time reaches more than 15 hours relative to the as-prepared sample.After annealing at temperatures higher than 880 °c, the persistent luminescence of the nanoparticles is enhanced, but they show aggregated-surface behavior.Meanwhile, shallow and deep traps are generated, related to the antisite defects and vge-cr(3+)-vo defect clusters, respectively.Finally, we apply zggo:cr(3+) persistent luminescence nanoparticles (plnps) to a human serum albumin (hsa) colloid solution, and more than 1 h of nir persistent luminescence is detected under 320 nm excitation.The quenching effect of nir luminescence by oh(-) in the hsa solution is observed based on the reduced contribution of surface cr(3+) in plnps to nir luminescence.Our results suggest that zggo:cr(3+) plnps have potential applications for in vivo bio-imaging.

Journal: Dalton transactions (Cambridge, England : 2003) (2016)
Publication types: Journal Article;Research Support, Non-U.S. Gov't