syedzayyan/paper_mill_benchmark huggingface dataset:
Comparative Analysis of Different Efficient Machine Learning Methods for Fetal Health Classification

Obstetricians often utilize cardiotocography (ctg) to assess a child’s physical health throughout pregnancy because it gives data on the fetal heartbeat and uterine contractions, which helps identify whether the fetus is pathologic or not.Obstetricians have traditionally analyzed ctg data artificially, which takes time and is unreliable.As a result, creating a fetal health classification model is essential, as it may save not only time but also medical resources in the diagnosis process.Machine learning (ml) is currently extensively used in fields such as biology and medicine to address a variety of issues, due to its fast advancement.This research covers the findings and analyses of multiple machine learning models for fetal health classification.The method was developed using the open-access cardiotocography dataset.Although the dataset is modest, it contains some noteworthy values.The data was examined and used in a variety of ml models.For classification, random forest (rf), logistic regression, decision tree (dt), support vector classifier, voting classifier, and k-nearest neighbor were utilized.When the results are compared, it is discovered that the random forest model produces the best results.It achieves 97.51% accuracy, which is better than the previous method reported.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Combination of Methotrexate and Leflunomide Is Efficient and Safe for 60 Patients with Rheumatoid Arthritis

The present work is aimed at exploring the clinical efficacy and safety of methotrexate (mtx) and leflunomide (lef) combination therapy for rheumatoid arthritis.From june 2019 to june 2021, a total of 120 individuals with rheumatoid arthritis received a diagnosis.Sixty patients each were randomly assigned to the control and observation groups.The observation group received mtx and lef combo medication while the control group only received mtx treatment.Clinical efficacy, complication incidence, and the alleviation of inflammatory markers, joint pain, and clinical symptoms were compared between the 2 groups.Posttreatment, the observation group had overall response rate of 96.66%, while the control group had 86.67%, with significant differences.Compared with pretreatment, both control and observation group patients showed decreasing trends of il-1 levels and increasing trends of il-10 levels posttreatment, with significant differences ( p &lt; 0.05 ).Compared with the control group, patients in the observation group had lower il-1 and tnf-α levels with significant differences ( p &lt; 0.05 ) and higher levels of il-10 with significant difference ( p &lt; 0.05 ).In both groups, the pain score and the number of painful joints were much lower than they were prior to treatment.Following treatment, the observation group displayed significantly lower levels of erythrocyte sedimentation rate, rheumatoid factor, and c-reactive protein than the control group ( p &lt; 0.05 ).Clinical measures in the observation group were all lower than those in the control group with statistically significant differences ( p &lt; 0.05 ).Moreover, the incidence rate of adverse reactions showed no significant difference between these 2 groups ( p &gt; 0.05 ).In conclusion, the combination therapy of mtx and lef is efficacious for rheumatic arthritis.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
College Calisthenics Teaching Based on Information Technology

Under the background of national fitness, aerobics has become a popular sport.Aerobics has a good fitness effect and is one of the compulsory courses of physical education.But it also puts forward higher requirements for college aerobics teaching.The traditional teaching method is no longer applicable.In order to improve the teaching effect of aerobics, this paper puts forward the research of college aerobics teaching method.In this paper, the traditional aerobics teaching methods and the current popular information teaching mode are analyzed in detail.Through the comparison, the traditional aerobics teaching process is too boring to stimulate students’ interest.But after the use of information technology teaching, students’ self-learning ability has been improved.In the study of the effect of traditional teaching mode and information-based teaching mode, this paper makes relevant experimental investigation.The physical fitness of the experimental group was p &gt; 0.05 .There were significant differences in basic physical qualities such as push-ups, rope skipping, and flexibility between the two groups ( p &lt; 0.05 ).the experimental data show that the use of information-based teaching mode is more conducive to students’ accurate grasp of action points, and because of the retrospectivity, students can consolidate knowledge and practice themselves more conveniently.The research of this paper promotes the innovation of traditional education, complements and promotes each other with traditional education, and creates greater learning and exploration space for students, in order to contribute to the construction of aerobics courses in colleges and universities.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
C-myc/TSPEAR-AS2 Axis Facilitates Breast Cancer Growth and Metastasis in a GLUT1-Dependent Glycolysis Manner

A large number of facts have shown that epigenetic modification and metabolic reprogramming represented by noncoding rna play an important role in the invasion and metastasis of breast cancer, but the mechanism is not clear.The purpose of our study is to find a new biomarker of breast cancer and to provide a new perspective for regulating glucose metabolism and aerobic glycolysis of bc.In this paper, by downregulating c‐myc protein, our team found that the expression of long‐chain noncoding rnatspar‐as2 was significantly downregulated.However, the expression of long‐chain noncoding rnaspar‐as2 in bc is relatively high, and the prognosis is poor.Tspear‐as2 can promote the malignant phenotype of bc cells, including proliferation, apoptosis, invasion and metastasis, and glycolysis.At the same time, tspear‐as2 can also upregulate the expression of glut1, an important regulator of glycolysis, thus promoting the metabolic reprogramming of bc.Molecular mechanism experiments show that tspear‐as2 may promote the expression of glut1 by participating in igf2bp2 modified by the glut1 gene.Our results suggest that the c‐myc/tspear‐as2/glut1 axis promotes the invasion and metastasis of bc by inducing glucose metabolism reprogramming.However, more phenotypic and molecular mechanism results need to be further verified.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Clustering of Brain Tumor Based on Analysis of MRI Images Using Robust Principal Component Analysis (ROBPCA) Algorithm

Automated detection of brain tumor location is essential for both medical and analytical uses.In this paper, we clustered brain mri images to detect tumor location.To obtain perfect results, we presented an unsupervised robust pca algorithm to clustered images.The proposed method clusters brain mr image pixels to four leverages.The algorithm is implemented for five brain diseases such as glioma, huntington, meningioma, pick, and alzheimer’s.We used ten images of each disease to validate the optimal identification rate.According to the results obtained, 2% of the data in the bad leverage part of the image were determined, which acceptably discerned the tumor.Results show that this method has the potential to detect tumor location for brain disease with high sensitivity.Moreover, results show that the method for the glioma images has approximately better results than others.However, according to the roc curve for all selected diseases, the present method can find lesion location.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Clinical Value of PET.CT Based on Big Data in Colorectal and Peritoneal Metastatic Cancer

This study focuses on the evaluation of the clinical utility of pet‐ct imaging in peritoneal metastases and colorectal cancer.One hundred patients with colorectal peritoneal metastases, who underwent whole‐body pet‐ct imaging from january 2015 to december 2019, were selected as the experimental group, and 20 healthy individuals were selected as the control group.The suvmax of the two groups of patients was 5.73 ± 3.84 and 2.70 ± 2.32, respectively, and the difference was statistically significant.The suvmax auc was 0.720, and the auc of serum afp, cea, ca125, and ca199 were 0.596, 0.677, 0.642, and 0.696, respectively.Conclusion .100 patients with colorectal and peritoneal metastatic cancer underwent pet/ct examination.The follow‐up or other imaging examinations confirmed the diagnosis.Analysis of the roc curve in this study found that with a peritoneal suvmax&gt; 3.2 as the diagnostic index for colorectal peritoneal metastatic cancer, the sum of sensitivity and specificity reached the maximum.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Clinical Observation of Computer Vision Technology Combined with Music Therapy in the Treatment of Alzheimer’s Disease

With the world’s population aging, alzheimer’s disease has attracted more and more attention as a common elderly disease.The clinical manifestations of cognitive function decline in alzheimer’s disease are mainly memory decline, which will seriously damage the patient’s sense of self-worth.The purpose is to use the method of song recall to conduct individual music therapy intervention for alzheimer’s disease patients, to help alzheimer’s disease patients activate autobiographical memory, trigger positive emotions, improve behavioral symptoms, and delay the development of the disease.This paper proposes to combine computer vision technology with music therapy to obtain relevant data before and after intervention through the literature method, measurement method, case study method and experimental method.It helps ad patients to improve and slow down the forgetting and confusion of autobiographical memory, thereby enhancing the mood and cognition of ad patients.It observes the changes of ad patients before and after intervention by song recall and provides new ideas and practical basis for the application of music therapy in the field of alzheimer’s disease research.The experimental results showed that the subjects’ autobiographical memory test (amt) after 16 sessions of music therapy, from 12 points before the test to 14 points after the test.The scores were significantly positively correlated, and the improvement of autobiographical memory could improve the patient’s orientation and memory.

Journal: Emergency Medicine International (2022)
Publication types: Research Article;
Clinical Features and Surgical Strategies of Distal Radius Posttraumatic Deformity

To investigate the clinical features and surgical strategies of distal radius posttraumatic deformity.Methods.A retrospective analysis was performed on the data of 30 patients with distal radius posttraumatic deformity treated by osteotomy and orthopedic surgery in the department of orthopedics, the first affiliated hospital of nanjing medical university, from february 2016 to november 2018.All the patients underwent preoperative anterior and lateral x-ray plain scanning of bilateral wrist joints, showing different degrees of radius shortening, inferior ulnar and radial mismatch, palmar angle, and ulnar deviation angle, among which 11 patients had an uneven joint surface.After a full evaluation, osteotomy and orthopedic surgery were performed to restore the original anatomical structure, plaster fixation was performed for two weeks after surgery, and regular outpatient follow-up was conducted.The function of the wrist was evaluated by the mmws (wrist joint improvement) scoring scale before and after surgery, and the changes in the wrist joint-related treatment parameters were evaluated according to x-ray.Results.All 30 patients had no neurological symptoms after surgery, and all wounds healed within the first stage.All patients were followed up for 6–12 months, with an average healing time of 3.5 months.There was no reduction loss, internal fixation loosening, or fracture in the regular postoperative review.Postoperative mmws (wrist joint improvement) score scale data were significantly higher than those before surgery, and there were differences between groups ( p &lt; 0.05 ).Postoperative treatment parameters of wrist joints such as palmar inclination angle, ulnar deviation angle, radius height, and lower ulnar and radial matching were significantly improved, and there were differences between groups ( p &lt; 0.05 ).Conclusions.The patients with distal radius posttraumatic deformity have the clinical characteristics of shortening of radius, mismatch of lower ulnar and radius, an abnormal inclination of palm, and ulnar declination.For patients with distal radius posttraumatic deformity, osteotomy and orthopedic surgery can effectively improve wrist function and improve patients’ quality of life, which is worthy of clinical reference.

Journal: Emergency Medicine International (2022)
Publication types: Research Article;
Clinical Evaluation of Efficacy on Ultrasound Combined with Neuromuscular Electrical Stimulation in Treating Lumbar Disc Herniation

To investigate the clinical efficacy of ultrasound (us) combined with neuromuscular electrical stimulation (nmes) in treating lumbar disc herniation (ldh) and its effect on the level of inflammatory factors.Methods.The data of 240 patients with ldh treated at our hospital from january 2020 to february 2021 were reviewed and classified into an us combined with nmes treatment group (us+nmes, n = 80 ), nmes only treatment group (nmes, n = 80 ), and us only treatment group (us, n = 80 ).Their visual analogue scale (vas) and oswestry disability index (odi) scores, levels of inflammatory factors and pain mediators, recovery rate, and total recovery time before and after treatment were compared.Additionally, the incidence of complications/adverse reactions was also investigated.Results.Compared with data before treatment, the three groups had lower vas and odi scores, inflammatory factor levels (interleukin- [il-] 1, il-6, and tumor necrosis factor- [tnf-] α), and pain mediators (transforming growth factor- [tgf-] β1, prostaglandin e2 [peg2], and 5-hydroxytryptamine [5-ht]) after treatment, with the most significant decrease observed in the us+nmes group.Compared with patients who received us or nmes treatment alone, patients from the us+nmes had faster recovery time and lower incidence of complications/adverse reactions.Conclusion.Collectively, us combined with nmes was associated with significant relief in pain and lumbar dysfunction and reduced local inflammatory response and pain mediator levels in ldh patients, suggesting that this combined approach could achieve better efficacy than us or nmes alone.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Clinical Evaluation and Exploration of Mechanisms for Modified Xiebai Powder or Modified Xiebai Powder Combined with Western Medicine in the Treatment of Pneumonia

To systematically evaluate the clinical efficacy of modified xiebai powder or modified xiebai powder combined with western medicine in the treatment of pneumonia and explore its potential mechanism of action.Methods.Meta-analysis was used to screen the eligible literature on randomized controlled trials (rcts) about xiebai powder in the treatment of pneumonia, and review manager 5.3 software was used for statistical analysis of the data.Based on the results of the meta-analysis, the active ingredients in xiebai powder and their therapeutic targets, disease-related targets, and intersection targets were screened using methods of network pharmacology, and their biological processes and key signaling pathways were analyzed using bioinformatics tools.Molecular docking was carried out to verify and predict the mechanisms for xiebai powder combined with western medicine in the treatment of pneumonia.Results.A total of 16 papers were screened out, with a total of 1,465 patients.The results of the meta-analysis showed that modified xiebai powder or modified xiebai powder combined with western medicine were superior to conventional western medicine in terms of clinical efficacy, shortening the disappearance time of symptoms (body temperature, cough, and pulmonary rales) and reducing the level of c-reactive protein, and the incidence of adverse reactions was significantly reduced.A total of 40 active ingredients in xiebai powder and 285 therapeutic targets of xiebai powder combined with azithromycin after deduplication were screened out from the database.Kegg enrichment analysis showed that xiebai powder combined with azithromycin might play a role in the treatment of pneumonia through the il-17 signaling pathway, tumor necrosis factor signaling pathway, c-type lectin receptor signaling pathway, toll-like receptor signaling pathway, and hif-1 signaling pathway.Conclusions.Modified xiebai powder or modified xiebai powder combined with azithromycin has better effects in treating pneumonia, and modified xiebai powder combined with azithromycin may play a role in treating pneumonia through several pathways such as the il-17 signaling pathway.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Meta-Analysis;
Clinical Efficacy and Safety Analysis of Levofloxacin for the Prevention of Infection after Traumatic Osteoarthrosis and Internal Fixation: Systematic Review and Meta-Analysis

Levofloxacin has been widely used in clinical anti-infection treatment; however, its adverse reactions to levofloxacin were also obvious in patients.Herein we aimed to systematically evaluate the clinical efficacy and safety of systemic administration of levofloxacin in the prevention of postoperative infection after traumatic osteoarthrosis and internal fixation.Methods.Pub med, cochrane library, ovid, ebsco, cnki, vip database, and wanfang database were searched from december 1993 to december 2021.Meanwhile, china adr information bulletin and who pharmaceutical were searched manually.Newsletter and fda drug safety newsletter, also to retrieve the websites of chinese, chinese, and drug regulatory authorities; to obtain data on adverse events in children with systemic administration of levofloxacin.The literature was screened according to inclusion and exclusion criteria.The risk of bias was evaluated for the included rct literature.Results.There was a statistical difference in the comparison of the incidence of fever between the experimental group and the control group (or = 2.29, 95% ci (1.75,2.98), p &lt; 0.00001 , i2 = 0%, z = 6.11); elevated white blood cell count (or = 1.82, 95% ci (1.31,2.52), p = 0.0003 , i2 = 0%, z = 3.60); incidence of wound infection (or = 2.11, 95% ci (1.54,2.90), p &lt; 0.00001 , i2 = 0%, z = 4.64); adverse drug reaction (or = 1.82, 95% ci (1.21,2.74), p = 0.004 , i2 = 0%, z = 2.86).Conclusion.In the clinical use of levofloxacin, adverse drug reactions including fever, elevated white blood cell count, and wound infection should be concerned.

Journal: Emergency Medicine International (2022)
Publication types: Meta-Analysis;
Clinical Effect of the Treatment of Lumbar Intervertebral Disc Protrusion

Compared with traditional acupuncture, it is urgently needed for more effective method for the disease to serve the clinical treatment.This paper combines acupuncture and massage to treat lumbar intervertebral disc protrusion, uses a controlled trial to study the clinical effects of acupuncture combined with massage for the treatment of lumbar intervertebral disc protrusion, combines mathematical statistics to test the data, and compares and analyzes the statistical object parameters.Through experimental research, it is known that in the treatment of lumbar intervertebral disc protrusion, in order to obtain a faster and better effect, traditional acupuncture treatment should be combined with massage therapy.On the basis of fully eliminating the pathological factors, the intervertebral disc is reset by mechanical treatment, which makes the patient more likely to heal.Therefore, it is a comprehensive treatment plan that is worth adopting.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Clinical Study;
Clinical Effect of Catgut Embedding plus Warm Needle Moxibustion on Improving Inflammation and Quality of Life of Knee Osteoarthritis Patients

To clarify influence of catgut embedding plus warm needle moxibustion on improving inflammation and quality of life of knee osteoarthritis patients.Materials and methods.The data of 120 patients with knee osteoarthritis admitted to our hospital from june 2018 to june 2021 were used for retrospective analysis.Patients were divided into control group and observation group in a random manner, with 60 cases each.The control group was orally administrated with one diclofenac sodium sustained-release tablet (100 mg) once a day, for 8 courses with 7 days for each course.The observation group underwent catgut embedding plus warm needle moxibustion.Results.The western ontario and mc master universities arthritis index and gonitis lequesne scores in two groups were decreased after treatment and were lower in observation group than control group ( p &lt; 0.05 ).Quality of life scores presented elevation after treatment and were higher in observation group than control group ( p &lt; 0.05 ).Curative efficacy presented no difference between two groups ( p &gt; 0.05 ), while clinical cure rate was higher in observation group than control group ( x 2 = 8.257 , p = 0.006 ).Conclusion.Warm needle moxibustion plus functional exercise can effectively improve clinical symptoms of knee osteoarthritis patients, and improve their knee joint function and inflammatory response.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Clinical Comparison of Preterm Birth and Spontaneous Preterm Birth in Severe Preeclampsia

Severe preeclampsia is accompanied by many complications, which is extremely harmful to pregnant women and fetuses.However, in the classification of preterm birth, it is generally divided into spontaneous preterm birth and therapeutic preterm birth, and insufficient attention has been paid to preterm birth in severe preeclampsia.This article aims to explore the clinical difference between preterm birth in severe preeclampsia and spontaneous preterm birth.In the experiment, this paper selected pregnant women who delivered and were treated in a hospital from april 2010 to april 2020 as cases.In terms of grouping, not only are they divided into severe eclampsia group (observation group 1), spontaneous preterm birth group (observation group 2), and general delivery group (control group) according to the cause of premature birth, but also according to the gestational age of severe eclampsia onset, preterm weeks, and other groups.Not only the clinical difference between severe preeclampsia preterm birth and spontaneous preterm birth was compared horizontally, but also the factors affecting the complications of preterm pregnant women, perinatal asphyxia rate, and mortality were longitudinally analyzed.The experimental results in this paper showed that there were significant differences in maternal complications and neonatal mortality between the severe preeclampsia preterm group and the spontaneous preterm group ( p &lt; 0.05).In addition, the severe preeclampsia preterm birth group was more harmful than the spontaneous preterm birth group.The complication rate of the severe preeclampsia preterm birth group was 10% higher than that of the spontaneous preterm birth group, and the neonatal mortality rate was 2% higher.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;