syedzayyan/paper_mill_benchmark huggingface dataset:
Renal Cell Carcinoma in Fistulizing Crohn's Disease Patient Who Received Anti-TNFαTherapy.

Inflammatory bowel diseases are chronic inflammatory diseases affecting the gastrointestinal tract with different clinical presentations.These chronic inflammatory diseases are associated with an increased risk for both intestinal and different types of extra-intestinal malignancies.In this case report, we describe the condition of a 29-year-old saudi male diagnosed with fistulizing ileal crohn's disease 7 years ago.The patient presented to the gastroenterology clinic with left flank pain for the last 2 months, which started gradually.The pain was dull, intermittent, and without a history of fever, dysuria, or hematuria.The patient was passing 3-4 times bowel motion, watery without blood or mucus.On examination, the patient looked well.Abdomen examination revealed a soft and lax abdomen with no tenderness or organomegaly.Ct abdomen showed a well-defined hypodense focal lesion originally from the left kidney near the hilum region with a clue sign.Colonoscopy was performed and showed only terminal ileitis.The patient was referred to a urologist for further action.The patient was seen by the urologist, and they are planning for partial left nephrectomy.The renal surgical specimen histopathology was reported later as renal cell carcinoma.

Journal: Case reports in gastrointestinal medicine (2021)
Publication types: Case Reports;Journal Article
Emerging Concepts and Applied Machine Learning Research in Patients with Drug-Induced Repolarization Disorders.

The paper presents a review of current research to develop predictive models for automated detection of drug-induced repolarization disorders and shows a feasibility study for developing machine learning tools trained on massive multimodal datasets of narrative, textual and electrocardiographic records.The goal is to reduce drug-induced long qt and associated complications (torsades-de-pointes, sudden cardiac death), by identifying prescription patterns with pro-arrhythmic propensity using a validated electronic application for the detection of adverse drug events with data mining and natural language processing; and to compute individual-based predictive scores in order to further identify clinical conditions, concomitant diseases, or other variables that correlate with higher risk of pro-arrhythmic situations.

Journal: Studies in health technology and informatics (2020)
Publication types: Journal Article;Review
Highly Transparent and Flexible Zn-Ti3C2TxMXene Hybrid Capacitors.

With the development of transparent and wearable electronic devices, energy supply units with high transmittance and flexibility, long cycle life, and high power and energy density are urgently needed.Zinc ion hybrid capacitors (zihcs) combined with the advantages of both supercapacitors and zinc ion batteries are promising energy supply components in the abovementioned devices.In addition, the preparation of multifunctional devices has become a trend for the need of space- and resource-saving.Therefore, obtaining zihcs with high transmittance and exploring their potential applications are meaningful challenges.Herein, a transparent and flexible zihc composed of a patterned zinc foil anode, transparent mxene cathode, and zn so4-polyacrylamide (pam) hydrogel electrolyte is designed and realized.The zihc exhibits a superior capacitance of 318 μf cm-2(5 m v s-1) with 94% transmittance and retains 76% of the initial capacitance after 10,000 charge-discharge cycles.It also shows excellent flexibility, i.e., its capacitance has no obvious attenuation under different bending states.Interestingly, the leakage current of the zihc is highly sensitive to electric fields, which shows potential application in electric field detection.This work presents a method to realize the multifunctional zihc with electric field sensing function for transparent and flexible wearable devices in the future.

Journal: Langmuir : the ACS journal of surfaces and colloids (2022)
Publication types: Journal Article
Venous thromboembolism incidence and risk factors in adults with acute lymphoblastic leukemia treated with and without pegylated E. coli asparaginase-containing regimens.

Asparaginases, key agents in treatment of acute lymphoblastic leukemia (all), are associated with venous thromboembolism (vte).While risks of short-acting asparaginase-related vte is well-known, we studied vte incidence and risk factors in adult all patients treated with and without long-acting pegylated asparaginase (peg a).Methods single-center, retrospective analysis of 89 all patients treated with (n = 61) or without (n = 28) peg a at greenebaum comprehensive cancer center.Reviewed patient and disease characteristics, treatment, and vte incidence.Results vte during treatment occurred in 31 patients (35%), and was associated with peg a (p = 0.001) and philadelphia chromosome negativity (p = 0.002).Among peg a recipients, vte was associated with a significantly higher mean body mass index (bmi) of 31.3 kg/m2(p = 0.037), and was more common with pre-t/t cell compared to pre-b/b cell all (68.2% vs.33.3%, p = 0.009).Antithrombin-iii (atiii) levels were measured for 26 patients; 16 (61.5%) were < 50%.Of those, 8 (50%) experienced vte, while 3 of 10 (30%) patients with atiii levels ≥ 50% experienced vte.Vte occurred in 7 of 13 (54%) of patients who received atiii repletion.There was a trend toward a higher incidence of vte in the peg a group among patients with non-o compared to o blood type (55.9% vs.33.3%, p = 0.079) as well as those with a higher hemoglobin at diagnosis (9.3 vs 8.1 g/d l, p = 0.056).Conclusion this study confirms peg a as a risk factor for vte in patients with all.Risk factors among those receiving peg a include higher bmi and pre-t/t cell all.Atiii repletion was not shown to be protective against vte.There was a higher incidence of vte in patients who received peg a with non-o compared to o blood type, but the precise correlation is uncertain.

Journal: Cancer chemotherapy and pharmacology (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Real-life Effectiveness of Omalizumab in Patients with Severe Allergic Asthma: RELIEF Study.

Introduction patients with severe allergic asthma (saa) are at risk of severe exacerbations.Omalizumab is recommended as an add-on treatment for patients with uncontrolled saa, despite high-dose inhaled corticosteroids and long acting β2-agonist combination therapy (standard therapy).relief was a prospective, open label, multicenter study conducted to assess the real-life effectiveness of omalizumab co-administered with standard therapy in patients with saa for 24 months.Methods a total of 347 patients aged ≥ 6 years with saa were enrolled, 285 of whom (8 pediatrics and 277 adolescents and adults) completed this 24-month study.Compared with the 12 months prior to baseline, the mean number of exacerbations was reduced in the overall population at any time interval during the study.Proportion of patients with no exacerbations increased to 77.7% at 24 months from 32.6% at 12 months prior to baseline.A reduction in healthcare resource utilization was also observed.The mean number of specialist visits reduced from baseline (5.8 visits) to 2.4 visits at month 24.Results the mean asthma control test score was >19 at every time-point during the study.The rate of global evaluation of treatment effectiveness (gete) for asthma response significantly increased at months 18 and 24 (p<0.05) compared to baseline.Pulmonary function remained relatively stable for the overall study population.There were no new or unexpected safety findings in the study.Conclusion relief study showed that add-on therapy with omalizumab is effective in reducing exacerbations, healthcare utilization, and improving gete score in patients with saa uncontrolled by standard therapy.

Journal: The open respiratory medicine journal (2022)
Publication types: Journal Article
Osthole inhibited TGF β-induced epithelial-mesenchymal transition (EMT) by suppressing NF-κB mediated Snail activation in lung cancer A549 cells.

Epithelial-mesenchymal transition (emt), the transdifferentiation of epithelial cells into mesenchymal cells, has been implicated in the metastasis and provides novel strategies for cancer therapy.Osthole (ost), a dominant active constituent of chinese herb cnidium monnieri, has been reported to inhibit cancer metastasis while the mechanisms remains unclear.Here, we studied the inhibitory effect and mechanisms of ost on tgf-β1-induced emt in a549 cells.Cells were treated with tgf-β1 in the absence and presence of ost.The morphological alterations were observed with a microscopy.The protein and m rna expressions were determined by western blotting and real-time pcr.The protein localization was detected with immunofluorescence.The adhesion, migration, and invasion were determined by matrigel, wound-healing, and transwell assays.Tgf-β1 treatment induced spindle-shaped alterations of cells, upregulation of n-cadherin, vimentin, nf-κb p65, and downregulation of e-cadherin.Dysregulated membrane expression and m rna expression of e-cadherin and n-cadherin were observed after tgf-β1 treatment.Tgf-β1 increased abilities of migration and invasion and triggered the nuclear translocation of nf-κb p65.These alterations were dramatically inhibited by ost.Furthermore, pdtc, a nf-κb inhibitor, showed similar effects.In addition, tgf-β1-induced expression of snail was significantly inhibited by ost and silenced snail partially reversed tgf-β1-induced emt biomarkers without affecting nf-κb p-65.In conclusion, ost inhibited tgf-β1-induced emt, adhesion, migration, and invasion through inactivation of nf-κb-snail pathways in a549 cells.This study provides novel molecular mechanisms for the anti-metastatic effect of ost.

Journal: Cell adhesion & migration (2017)
Publication types: Journal Article
Fucosyltransferase 2: A Genetic Risk Factor for Intestinal Diseases.

The fucosyltransferase 2 gene (fut2) mediates the synthesis of histoblood group antigens (hbga) that occurin vivofrom multiple organs, particularly on the surface of intestinal epithelial cells and body fluids.To date, many studies have demonstrated that the interaction of hbga with the host microbiota is the cause of pathogenesis of intestinal diseases, making fut2non-secretor a risk factor for inflammatory bowel disease (ibd) due to the lack of hbga.As hbga also acts as an attachment site for norovirus (no v) and rotavirus (rv), the non-secretor becomes a protective factor for both viral infections.In addition, the interaction of norovirus and rotavirus with symbiotic bacteria has been found to play an important role in regulating enteroviral infection in ibd.Given the current incomplete understanding of the complex phenomenon and the underlying pathogenesis of intestinal diseases such as ibd, it has recently been hypothesized that the fut2gene regulates intestinal bacteria through attachment sites, may help to unravel the role of fut2and intestinal flora in the mechanism of intestinal diseases in the future, and provide new ideas for the prevention and treatment of intestinal diseases through more in-depth studies.

Journal: Frontiers in microbiology (2022)
Publication types: Journal Article;Review
Malnutrition and maternal vaccination against typhoid toxin.

Children are particularly susceptible to typhoid fever caused by the bacterial pathogen salmonella typhi.Typhoid fever is prevalent in developing countries where diets can be less well-balanced.Here, using a murine model, we investigated the role of the macronutrient composition of the diet in maternal vaccination efficacies of two subunit vaccines targeting typhoid toxin: toxoid vac and plt bvac.We found that maternal vaccinations protected all offspring against a lethal-dose typhoid toxin challenge in a balanced, normal diet (nd) condition, but the declined protection in a malnourished diet (md) condition was observed in the plt bvac group.Despite the comparable antibody titers in both md and nd mothers, md offspring had a significantly lower level of typhoid toxin neutralizing antibodies than their nd counterparts.We observed a lower expression of the neonatal fc receptor on the yolk sac of md mothers than in nd mothers, agreeing with the observed lower antibody titers in md offspring.Protein supplementation to md diets, but not fat supplementation, increased fc rn expression and protected all md offspring from the toxin challenge.Similarly, providing additional typhoid toxin-neutralizing antibodies to md offspring was sufficient to protect all md offspring from the toxin challenge.These results emphasize the significance of balanced/normal diets for a more effective maternal vaccination transfer to their offspring.

Journal: PLoS pathogens (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Immuno-modulation by heat-killedLacticaseibacillus paracaseiMCC1849 and its application to food products.

Probiotics are microorganisms that confer health benefits to host.Well-known examples include bifidobacteriumand lactobacillusspecies.In recent years, interest in promoting our health with probiotics has grown as life expectancy and health awareness has increased.However, some concerns for safety and stability exist for these live organisms.Thus, "postbiotics" and "paraprobiotics," non-viable heat-killed microbial cells or cell fractions that retain health benefits, are increasingly favored.Unfortunately, little information on clinical efficacy and mechanisms of action is available compared with many available probiotics.lacticaseibacillus(previous name lactobacillus)paracasei mcc1849 is a commonly used lactic acid bacterial strain in japan that displays immuno-modulatory effects in humans in non-viable heat-killed form.This review discusses health benefits of heat-killed l.Paracasei mcc1849 immune modulation and offers a theoretical basis for its mechanisms of action.We also discuss the feasibility of using heat-killed probiotics for application in food products.

Journal: International journal of immunopathology and pharmacology (2021)
Publication types: Editorial;Review
O 089 - A soft robotic exosuit assisting the paretic ankle in patients post-stroke: Effect on muscle activation during overground walking.

This study compared overground walking with and without exosuit assistance in post-stroke patients.Exosuit-assisted walking was found to improve paretic propulsion and ground clearance during swing, two common gait deviations in stroke patients.No changes in leg muscle activity was found, motivating further study of the exosuit as a tool for gait training during stroke rehabilitation.

Journal: Gait & posture (2022)
Publication types: Journal Article
From the Paper to the Tablet: On the Design of an AR-Based Tool for the Inspection of Pre-Fab Buildings. Preliminary Results of the SIRAE Project.

Energy-efficient buildings (ee b) are demanded in today&rsquo;s constructions, fulfilling the requirements for green cities.Pre-fab buildings, which are modularly fully-built in factories, are a good example of this.Although this kind of building is quite new, the in situ inspection is documented using traditional tools, mainly based on paper annotations.Thus, the inspection process is not taking advantage of new technologies.In this paper, we present the preliminary results of the sirae project that aims to provide an augmented reality (ar) tool that can seamlessly aid in the regular processes of pre-fab building inspections to detect and eliminate the possible existing quality and energy efficiency deviations.In this regards, we show a description of the current inspection process and how an interactive tool can be designed and adapted to it.Our first results show the design and implementation of our tool, which is highly interactive and involves ar visualizations and 3d data-gathering, allowing the inspectors to quickly manage it without altering the way the inspection process is done.First trials on a real environment show that the tool is promising for massive inspection processes.

Journal: Sensors (Basel, Switzerland) (2018)
Publication types: Journal Article
Nitrogen-rich ion salts of 1-hydroxytetrazole-5-hydrazide: a new series of energetic compounds that combine good stability and high energy performance.

High-efficiency explosives that combine high stability and excellent energy performance are one of the key directions of energetic materials research.In this study, a novel monocyclic hydroxytetrazole derivative (3) with high stability was prepared, and a series of insensitive energetic ionic salts were derived from it.Benefiting from their outstanding performance in terms of density, 3d hydrogen bonding and π-electron interactions, these salts are excellent in both detonation performance (d= 8709 to 9314 m s-1and p= 29.9 to 35.6 gpa) and thermal stability (td= 193.0-232.2 °c).The hydrazine salt (2) exhibits high detonation properties (d= 9314 m s-1and p= 35.6 gpa), due to its high density (ρ= 1.71 g cm-3) and high heat of formation (δf h= 563.2 k j mol-1= 3.19 k j g-1).In addition, the high thermal stability (td= 232.0 °c) and low mechanical sensitivity (is = 30 j and fs = 360 n) of 2 are also unmatched by hmx and tkx-50.These improved properties demonstrate the great promise of 2 as an insensitive high-energy explosive.

Journal: Dalton transactions (Cambridge, England : 2003) (2022)
Publication types: Journal Article
Optimized Simulation of Upper Body Timing on the Production of Bat-Head Speed in Baseball Batting.

The objectives of this study were to (1) investigate the effect of the timing of the upper body joint motions in baseball batting on the bat-head speed and (2) develop and evaluate a simulation model inputting the individual hand forces on the bat.Twenty-three male collegiate baseball players performed tee batting set at waist height.A 10-segment angle-driven simulation model consisting of a bat and upper body was driven using the coordinate data of the standard motion.Performance optimization was conducted by changing the timing of the joint angle time histories of the upper body to increase the maximum bat-head speed.The optimization simultaneously estimated the individual hand forces by polynomial approximation dependent on the total bat forces to assess joint torques of the upper body.The bat-head speed increased to 39.2 m/s from 35.6 m/s, and the optimized timings were characterized by the earlier timing of the barrel-side elbow supination, wrist radial flexion, torso right lateral flexion, and the later timing of the barrel-side shoulder abduction.It is concluded that the skillful coordination of the individual joint movements for the upper body can produce a higher bat-head speed through effective sequencing of proximal to distal movements.

Journal: Journal of applied biomechanics (2022)
Publication types: Journal Article
Crystal structure, Hirshfeld surface analysis and geometry optimization of 2-hy-droxy-imino-N-[1-(pyrazin-2-yl)ethyl-idene]propano-hydrazide.

In the mol-ecule of the title compound, c9h11n5o2, the oxime and hydrazide groups are situated in acis-position in relation to the c-c bond linking the two functional groups.The ch3c(=noh)c(o)nh fragment deviates from planarity because of a twist between the oxime and amide groups.In the crystal, mol-ecules are linked by o-h⋯o hydrogen bonds, forming zigzag chains in the [013] and [03] directions.

Journal: Acta crystallographica. Section E, Crystallographic communications (2022)
Publication types: Journal Article
Research on Herbal Therapies for Osteoarthritis in 2004-2022: A Web of Science-Based Cross-Sectional Bibliometric Analysis.

The extent, range, and nature of available research in the field of herbal therapies for osteoarthritis (oa) have not been systematically analyzed.This study aimed to map the literature available on herbal therapies for oa and identify global hotspots and trends in this field.Methods studies on herbal therapies for oa published between 2004 and 2022 were searched from the web of science core collection.Microsoft excel, spss statistics, and cite space software were used to analyze and visualize the quantity and citations of publications, and the research hotspots and trends in research on herbal therapies for oa.Results a total of 1649 publications mainly from 76 countries/regions and 270 institutions were included in this study.From 2004 to 2022, there is an upward trend in the publications of herbal therapies for oa.China ranked first in the number of publications (n= 568, 34.45%), followed by the usa (n= 353, 21.41%), south korea (n= 187, 11.34%), germany (n= 85, 5.15%), and england (n= 79, 4.79%).Kyung hee university (n= 46), xianxiang liu (n= 25), and evidence-based complementary and alternative medicine(n= 74) were the most prolific affiliation, author, and journal, respectively.Felson dt (n= 185) and arthritis and rheumatism(n= 1173) held the record for the most cited papers by an author and journal, respectively.Currently, the hot keywords in the field of herbal therapies for oa include knee oa, traditional chinese medicine (tcm), differentiation, rosa canina, inflammation, oxidative stress, stem cell, and regenerative medicine.The emerging research trends in herbal therapies for oa are herbal medicinal product, chronic knee pain, mesenchymal stem cell, and clinical pharmacology.Conclusions research on herbal therapies for oa is flourishing, but communication among countries/regions should be strengthened.Current research on herbal therapies for oa mainly focuses on knee oa, tcm, differentiation, rosa canina, inflammation, oxidative stress, stem cell, and regenerative medicine.The research frontiers are herbal medicinal product, chronic knee pain, mesenchymal stem cell, and clinical pharmacology.

Journal: Evidence-based complementary and alternative medicine : eCAM (2022)
Publication types: Journal Article
Planning for the next pandemic: Reflections on the early phase of the Australian COVID-19 public health response from the emergency department.

Eds play a crucial role as frontline health services throughout public health emergencies, including pandemics.The strength of the australian public health response to coronavirus disease 2019 (covid-19) has mitigated the impact of the pandemic on clinical services, but there has still been a substantial impact on eds and the health system.We revisit major events and lessons from the first wave of covid-19 in australia to consider the implications and avenues for system-level improvements for future pandemic and public health emergency response for eds.Notwithstanding, the remarkable efforts of healthcare workers across the health system, covid-19 has uncovered structural and planning challenges and highlighted weaknesses and strengths of the australian federation.In anticipating future pandemics and other public health threats, particularly in the face of climate change, hard-won lessons from the covid-19 response should be incorporated in future planning, policies, practice and advocacy.

Journal: Emergency medicine Australasia : EMA (2021)
Publication types: Journal Article