syedzayyan/paper_mill_benchmark huggingface dataset:
Evaluation of Therapeutic Effect and Prognosis of Danzhi Xiaoyao Powder Combined with Photodynamic Therapy in the Treatment of Rose Acne

Rose acne is a chronic inflammatory skin disease that can cause paroxysmal flushing, persistent erythema, papules or papules on the face, and pustules, and it has a greater impact on the life of patients, so it is important to treat it.Objective.To investigate the effect of danzhi xiaoyao powder combined with photodynamic therapy (pdt) on the curative effect evaluation and prognosis of patients with rose acne.Patients and methods.The clinical data of 110 rose acne patients who were treated in our hospital from january 2019 to january 2021 were selected as the subject of this retrospective study.They were divided into a control group and a treatment group according to the random residue grouping method.The new crown epidemic, loss to follow-up, etc.Fell out of 5 cases in each group, and finally, 50 cases in each group were left.Among them, the control group was treated with pdt, and the treatment group was combined with danzhi xiaoyao powder on the basis of the control group.Then we observe and compare the effects of skin lesion scores and clinical symptom scores and differences in clinical efficacy between the two groups.Results.The comparison of the clinical symptom scores of the two groups of patients before treatment was not statistically significant ( p &gt; 0.05 ), while the burning score, tingling score, dryness score, and pruritus score of the treatment group after treatment were significantly different.The internal comparison after treatment was lower than before treatment, and the comparison between the treatment groups was significantly higher than the control group, which was statistically significant ( p &lt; 0.05 ).There was no statistically significant difference in the skin lesion scores of the two groups before treatment ( p &gt; 0.05 ), while the papules score, pustule score, erythema score, and telangiectasia score of the treatment group after treatment were significantly different and compared within the group.After treatment, the treatment group was significantly higher than the control group, and the comparison was statistically significant ( p &lt; 0.05 ).The effective rate of 98.00% in the treatment group was significantly higher than the 76.00% in the control group, and the difference was statistically significant ( p &lt; 0.05 ).The clinical efficacy of the two groups of patients showed that the rash, chest tightness, nausea, and diarrhea of the treatment group were significantly lower than those of the control group, and the difference was statistically significant ( p &lt; 0.05 ).Conclusion.Danzhi xiaoyao powder combined with pdt to treat rose acne is effective, can quickly control inflammatory papules and inflammatory erythema, effectively improve the clinical symptoms of patients, and reduce adverse reactions.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
LncRNA MALAT1 increases the stemness of gastric cancer cells via enhancing SOX2 mRNA stability

Gastric cancer is one of the most common malignancies globally; cancer stem cells ( csc s) are regarded as being at the root of tumor progression, and there is thus a need to identify potential drugs to target csc s.The long non‐coding rna malat 1 promotes epithelial–mesenchymal transition and angiogenesis in colorectal cancer, but it is unknown whether it affects the stemness of gastric cancer cells.Here, we found that knockdown (kd) of malat 1 attenuated the stemness of non‐adherent gastric cancer cell spheroids, as evidenced by a decrease in primary and secondary spheroid formation capacity and expression of stemness markers.In contrast, overexpression (oe) of malat 1 enhanced the stemness of adherent gastric cancer cells.Notably, kd of malat 1 enhanced radiosensitivity and chemosensitivity of gastric cancer cell spheroids.We report that malat 1 directly binds to sox2 m rna (which encodes a critical master pluripotency factor), enhances the m rna stability and increases its expression; kd of sox2 partially reversed the effect of malat 1 oe on the stemness of gastric cancer cells.Importantly, expression of malat 1 and sox2 exhibited a positive correlation in clinical samples.Therefore, our results indicate the existence of a novel malat 1–sox2 axis which promotes the stemness of gastric cancer cells and may be a potential target for gastric cancer.

Journal: FEBS Open Bio (2019)
Publication types: Research Article;
HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail

Background liver cancer is one of the main causes of cancer-related death in human.Hoxa7 has been proved to be related with several cancers.Method the expression levels of hoxa7 were examined by western blot, q rt-pcr or ich.Mtt was used to detect the proliferative rate of liver cancer cells.The invasive abilities were examined by matrigel and transwell assay.The metastatic abilities of liver cancer cells were revealed in balb/c nude mice.Results in this report, we revealed that hoxa7 promoted metastasis of hcc patients.First, increased levels of hoxa7 were examined in liver cancer especially in metastatic liver cancer.Moreover, higher expression level of hoxa7 was associated with poorer prognosis of liver cancer patients.Overexpression of hoxa7 significantly enhanced proliferation, migration, invasion in vitro and tumor growth and metastasis in vivo meanwhile silencing hoxa7 significantly inhibited the aboves abilities of liver cancer cells.In this research, we identified that hoxa7 performed its oncogenic characteristics through activating snail .Conclusion collectively, we identify the critical role and possible mechanism of hoxa7 in metastasis of liver cancer which suggest that hoxa7 may be a potential therapeutic target of liver cancer patients.

Journal: Molecular Cancer (2016)
Publication types: Research Article;
Targeting a novel LncRNA SNHG15/miR-451/c-Myc signaling cascade is effective to hamper the pathogenesis of breast cancer (BC) in vitro and in vivo

Background to our knowledge, lnc rna snhg15 exerted its tumor-promoting effects to facilitate the development of breast cancer (bc), but there still needed more data to elucidate the potential underlying mechanisms.Methods we examined genes expression status by performing real-time q pcr and western blot analysis, and cellular functions, including cell proliferation, viability, apoptosis, mobility, were measured by using the cck-8 assay, colony formation assay, trypan blue staining assay, flow cytometer (fcm), transwell assay and wound scratch assay, respectively.The predicted targeting sites in lnc rna snhg15, mi r-451 and c-myc 3′utr were validated by dual-luciferase reporter gene system assay.Finally, we established the tumor-bearing mice models, and the expression status, including its enrichment and cellular localization were examined by immunohistochemistry (ihc) assay.Results our data indicated lnc rna snhg15 upregulated c-myc to facilitate bc progression by sponging mi r-451 in a competing endogenous rna (ce rna)-dependent manner in vitro and in vivo.Specifically, lnc rna snhg15 and c-myc were upregulated, while mi r-451 was downregulated in bc cells and clinical tissues, compared to their normal counterparts.In addition, mi r-451 negatively correlated with lnc rna snhg15 and c-myc, and lnc rna snhg15 was positively relevant to c-myc in bc tissues.Next, we validated that lnc rna snhg15 sponged mi r-451 to upregulate c-myc in bc cells.Further gain- and loss-of-function experiments evidenced that lnc rna snhg15 promoted, while mi r-451 inhibited malignant phenotypes, including cell proliferation, viability, migration, invasion and epithelial-mesenchymal transition (emt) in bc cells.Interestingly, the inhibiting effects of lnc rna snhg15 ablation on bc progression were abrogated by both silencing mi r-451 and overexpressing c-myc.Conclusions we concluded that targeting the lnc rna snhg15/mi r-451/c-myc signaling cascade was novel to hamper bc progression, which broadened our knowledge in this field, and provided potential biomarkers for bc diagnosis and treatment.

Journal: Cancer Cell International (2021)
Publication types: Research Article;
Energy transition, sustainable development opportunities, and carbon emissions mitigation: Is the developed world converging toward SDGs-2030?

The success of sustainable development heavily depends on successful energy transition toward renewable or carbon-free energy sources.This study attempted to analyze the impact of sustainable development and environmental initiatives on sustainable energy transition in selected oecd economies.For this purpose, the study generated the dataset of environment air and ghg emission, environmental-related technologies, development (gross domestic product, trade openness, and gross domestic spending on r&amp;amp;d) and sustainable environment (air and ghg emission and environmental-related technologies), and energy sources (renewable energy consumption, nonrenewable energy consumption, and sum of total energy consumption) of selected economies of oecd between 2000 and 2020.This study utilized dynamic panel gmm for regression analysis, and fmols and dols were applied as the robustness models.Empirical results indicated that sustainable development and a sustainable environment contribute positively to the energy transition process in oecd economies.However, these factors also negatively contribute to non-renewable energy consumption in oecd.Thus, the study’s outcomes confirmed the sustainable energy transition in oecd.Therefore, this study suggested that the success of sustainable development goals depends on successful energy transition.

Journal: Frontiers in Environmental Science (2022)
Publication types: Research Article;
Efficiency measurement and spatial spillover effect of green agricultural development in China

Green agriculture is mainstream for the sustainable development of agriculture.Based on the chinese provincial agriculture panel data from 2010 to 2019, we adopted the slack-based measure (sbm) super-efficiency model, sales force automation (sfa) model, and global malmquist–luenberger (gml) production index to measure the efficiency of agricultural green development (agd).Moreover, moran’s i and spatial econometric model were applied to analyze factors influencing agd.The threshold model was used to analyze the relationship between the scale of agd and gross domestic product (gdp).The results show that 1) chinese green agricultural development efficiency is on a rising trend, reducing the impact of environmental factors and random interference on the agd.2) the analysis of agd in the spatial effect showed a direct positive effect from agricultural mechanization, science and technology innovation, industrial agglomeration, income level, and environmental rule and a direct negative effect from agricultural yield structure, farmland pollution, and agricultural disasters.Furthermore, industrial structure optimization and environmental rule evoke a demonstration effect, but technical innovation, income level, and agricultural industrial agglomeration triggered a siphonic effect.3) the threshold model was used to analyze the scale of agd to realize sustainable development between agriculture and economy.

Journal: Frontiers in Environmental Science (2022)
Publication types: Research Article;
CAR-NK Cell: a new paradigm in tumor immunotherapy

The tumor microenvironment (tme) is greatly multifaceted and immune escape is an imperative attribute of tumors fostering tumor progression and metastasis.Based on reports, the restricted achievement attained by t cell immunotherapy reflects the prominence of emerging other innovative immunotherapeutics, in particular, natural killer (nk) cells-based treatments.Human nk cells act as the foremost innate immune effector cells against tumors and are vastly heterogeneous in the tme.Currently, there exists a rapidly evolving interest in the progress of chimeric antigen receptor (car)-engineered nk cells for tumor immunotherapy.Car-nk cells superiorities over car-t cells in terms of better safety (e.g., absence or minimal cytokine release syndrome (crs) and graft-versus-host disease (gvhd), engaging various mechanisms for stimulating cytotoxic function, and high feasibility for ‘off-the-shelf’ manufacturing.These effector cells could be modified to target various antigens, improve proliferation and persistence in vivo , upturn infiltration into tumors, and defeat resistant tme, which in turn, result in a desired anti-tumor response.More importantly, car-nk cells represent antigen receptors against tumor-associated antigens (taas), thereby redirecting the effector nk cells and supporting tumor-related immunosurveillance.In the current review, we focus on recent progress in the therapeutic competence of car-nk cells in solid tumors and offer a concise summary of the present hurdles affecting therapeutic outcomes of car-nk cell-based tumor immunotherapies.

Journal: Frontiers in Oncology (2021)
Publication types: Review Article;
The COVID-19 fear, anxiety, and resilience among emergency nurses

Besides physical complications, covid-19 is associated with psychological issues such as fear and anxiety.High resilience in nurses enables them to adopt positive coping mechanisms and successfully operate in the stressful environment of covid-19 wards.The present study aimed to evaluate the correlation between covid-19 fear and anxiety with resilience in the emergency nurses of the hospital affiliated with kurdistan university of medical sciences (west of iran) in 2021.Materials and methods this cross-sectional study was conducted on 295 emergency nurses of selected hospitals in kurdistan province, iran, in 2021.Data were collected using a demographic questionnaire, fear of covid-19 scale (fcv-19s), corona disease anxiety scale (cdas), and connor-davidson resilience scale (cd-risc).Data analysis was performed in r software version 3.6.3.Results the mean scores of resilience, covid-19 fear, and covid-19 anxiety were 55.07 ± 19.82 (ranging from 0 to 100), 20 ± 7.37 (ranging from 7 to 35) and 36.48 ± 13.21 (ranging from 18 to 54) respectively.There was a negative and significant correlation between resilience with covid-19 fear ( r = −0.449, p = 0.001), covid-19 anxiety ( r = 0.458, p = 0.001).A significant correlation was observed between covid-19 fear and anxiety, which indicated that if the other demographic variables remained unchanged, a one-unit increase in covid-19 fear and anxiety decreased the mean resilience score by −0.66 ( p = 0.008) and −0.34 ( p = 0.015), respectively.Conclusion covid-19 fear and anxiety were significantly correlated.Therefore, providing training courses for promoting resilience could reduce the fear and anxiety of nurses during the covid-19 pandemic.

Journal: Frontiers in Psychology (2022)
Publication types: Research Article;
A deep insight into CAR-T cell therapy in non-Hodgkin lymphoma: application, opportunities, and future directions

Non-hodgkin’s lymphoma (nhl) is a cancer that starts in the lymphatic system.In nhl, the important part of the immune system, a type of white blood cells called lymphocytes become cancerous.Nhl subtypes include marginal zone lymphoma, small lymphocytic lymphoma, follicular lymphoma (fl), and lymphoplasmacytic lymphoma.The disease can emerge in either aggressive or indolent form.5-year survival duration after diagnosis is poor among patients with aggressive/relapsing form of nhl.Therefore, it is necessary to understand the molecular mechanisms of pathogenesis involved in nhl establishment and progression.In the next step, we can develop innovative therapies for nhl based on our knowledge in signaling pathways, surface antigens, and tumor milieu of nhl.In the recent few decades, several treatment solutions of nhl mainly based on targeted/directed therapies have been evaluated.These approaches include b-cell receptor (bcr) signaling inhibitors, immunomodulatory agents, monoclonal antibodies (m abs), epigenetic modulators, bcl-2 inhibitors, checkpoint inhibitors, and t-cell therapy.In recent years, methods based on t cell immunotherapy have been considered as a novel promising anti-cancer strategy in the treatment of various types of cancers, and particularly in blood cancers.These methods could significantly increase the capacity of the immune system to induce durable anti-cancer responses in patients with chemotherapy-resistant lymphoma.One of the promising therapy methods involved in the triumph of immunotherapy is the chimeric antigen receptor (car) t cells with dramatically improved killing activity against tumor cells.The car-t cell-based anti-cancer therapy targeting a pan–b-cell marker, cd19 is recently approved by the us food and drug administration (fda) for the treatment of chemotherapy-resistant b-cell nhl.In this review, we will discuss the structure, molecular mechanisms, results of clinical trials, and the toxicity of car-t cell-based therapies.Also, we will criticize the clinical aspects, the treatment considerations, and the challenges and possible drawbacks of the application of car-t cells in the treatment of nhl.

Journal: Frontiers in Immunology (2021)
Publication types: Review Article;
Psychometric assessment of the Persian translation of the interpersonal mindfulness scale with undergraduate students

Interpersonal mindfulness is a construct that significantly contributes to social interaction.To date, no validated measure assessing interpersonal mindfulness has been developed in iran.Therefore, the aim of this study was to translate and validate the interpersonal mindfulness scale (ims) among iranian undergraduate students.Participants in the study (370 undergraduate students; 220 females) from the azad university completed the translated ims, the five facet mindfulness questionnaire, and the inventory of interpersonal problems scale.The translated measure demonstrated acceptable face validity.All items had acceptable content validity and were deemed essential to the scale.The results of a confirmatory factor analysis (cfa) confirmed a scale with four subscales (presence, awareness of self and others, non-judgmental acceptance, and non-reactivity), with acceptable internal consistency.The findings support the psychometric properties of the persian translated interpersonal mindfulness scale, which could be used to measure interpersonal mindfulness among undergraduate students in iran.

Journal: Frontiers in Psychiatry (2022)
Publication types: Research Article;
Sustainable financial dimensions of managing poverty in the era of the COVID-19 pandemic: a developing country perspective

The covid-19 pandemic is dangerous to people’s lives and livelihoods, creating immediate obstacles for organizations that support impacted populations.This research concentrates on the consequences for local microfinance institutions in pakistan, which is a well-developed sector that has pulled many households out of the poverty trap.Microfinance programs in pakistan provide financial resources to vulnerable and deprived people to engage in income-generating practices on more favorable terms.As a result, this study addressed and assessed the financial dimensions of managing poverty reduction in rural pakistan through the microfinance segment and its effectiveness on poverty-reduction programs in pakistan during the covid-19 pandemic.The primary data were collected through a questionnaire survey to determine the views of the households, beneficiaries, and non-beneficiaries on the outcome and efficacy of poverty-reduction programs during the pandemic to meet the study objectives.The mann-whitney u test of the non-parametric method and cronbach’s alpha of the data reliability test have been applied for the empirical analysis.According to the non-parametric findings, programs, marital status, working women members, and resources such as land, livestock, business assets, shares, and loans have all been affected during the covid-19 pandemic.Education, wages, gender, size, child dependency, and district variables are significant factors related to poverty, but they fell into second position during covid-19.These findings suggests that the small loan system must be improved and made efficient during the pandemic.This could be a practical tool to maintain poor people’s current economic and poverty position.

Journal: Frontiers in Environmental Science (2022)
Publication types: Research Article;
PM2.5, household income, and health hazard: the role of economic integration in the process of decarbonization in the developing economies

The goal of this study is to examine the impact of household income and air pollution on the health of developing-country residents.The panel dataset of twelve developing nations used for this purpose.High levels of fine particulate matter in the air are linked to increased health problems, and lower incomes for households in the economies studied.However, effective environmental management and renewable energy resources have a significant role in controlling the harmful impact of fine particulate matter in the air.It highlights that developing economies could lower the fine particulate matter in the air by strengthening the regional environmental policies and adopting renewable resources.In emerging countries, environmentally friendly strategies and the shift from carbon base to non-carbon-based energy would minimize pollution in the atmosphere and improve the quality of life for inhabitants and other organisms.Improved quality of life and lower levels of fine particulate matter pollution are expected to increase people’s per capita income in the region.Finally, air pollution is a transboundary phenomenon; therefore, strict compliance with environmental protection policies at the regional level is a prerequisite for improved quality of the natural environment.

Journal: Frontiers in Environmental Science (2022)
Publication types: Research Article;
Synthesis of bioactive yttrium-metal–organic framework as efficient nanocatalyst in synthesis of novel pyrazolopyranopyrimidine derivatives and evaluation of anticancer activity

Novel yttrium-metal–organic framework (y-mof) was synthesized under optimal conditions of microwave with a power of 20 w, the temperature of 30 degrees of centigrade, and time duration of 10 min.The products were characterized by sem (morphology and size distribution), tga (thermal stability), bet technique (surface area), and ftir (characterization of the related group).The yttrium-metal–organic framework (y-mof) synthesized in this study, after identifying and confirming the structure, was used as an efficient and recyclable catalyst in the synthesis of new pyrazolopyranopyrimidine derivatives.Following the study of the properties and applications of y-mof, its anticancer properties on breast cancer cells based on the mtt method were evaluated, and significant results were observed.In addition, the anticancer properties of the pyrazolopyranopyrimidine derivatives were investigated.

Journal: Frontiers in Chemistry (2022)
Publication types: Research Article;