syedzayyan/paper_mill_benchmark huggingface dataset:
The Effect of Liposomal Curcumin as an Anti-Inflammatory Strategy on Lipopolysaccharide e fromPorphyromonas gingivalisTreated Endothelial Committed Neural Crest Derived Stem Cells: Morphological and Molecular Mechanisms.

Curcumin, a yellow polyphenol extracted from the turmeric root is used as a diet supplement.It exhibits anti-inflammatory, antioxidant, and antitumor properties by modulating different intracellular mechanisms.Due to their low solubility in water, the curcumin molecules must be encapsulated into liposomes to improve the bioavailability and biomedical potential.For the periodontal tissue and systemic health, it is essential to regulate the local inflammatory response.In this study, the possible beneficial effect of liposomes loaded with curcumin (cur lip) in neural crest-derived human periodontal ligament stem cells (h pdlscs) and in endothelial-differentiated h pdlscs (e-h pdlscs) induced with an inflammatory stimulus (lipopolysaccharide obtained from porphyromonas gingivalis, lps-g) was evaluated.The cur lip formulation exhibited a significant anti-inflammatory effect by the downregulation of toll-like receptor-4 (tlr4)/myeloid differentiation primary response 88 (my d88)/nuclear factor kappa light chain enhancer of activated b cells (nfk b)/nlr family pyrin domain containing 3 (nlrp3)/caspase-1/interleukin (il)-1β inflammation cascade and reactive oxygen species (ros) formation.Moreover, the exposure to lps-g caused significant alterations in the expression of epigenetic modifiers, such as dna methyltransferase 1 (dnmt1) and p300, while the cur lip treatment showed physiological expression.Overall, our in vitro study provides novel mechanistic insights into the intracellular pathway exert by cur lip in the regulation of inflammation and epigenetic modifications.

Journal: International journal of molecular sciences (2021)
Publication types: Journal Article
Sensitivity and specificity of potassium hydroxide and calcofluor white stain to differentiate between fungal andPythiumfilaments in corneal scrapings from patients ofPythiumkeratitis.

To assess the sensitivity of potassium hydroxide and calcofluor white (koh+cfw) mount in the diagnosis of pythium keratitis and concordance among microbiologists.Methods three microbiologists evaluated the microscopic images of koh + cfw mounts of confirmed cases of pythium and fungal keratitis seen between january 2019 and february 2021.The filaments were compared using specific differentiating features.The sensitivity and specificity of koh + cfw in diagnosing pythium infection were evaluated along with concordance among the microbiologists.Results sixty consecutive cases with confirmed growth of fungus or pythium insidiosum (n = 29) were evaluated.The sensitivity of koh + cfw in the correct identification of pythium filaments ranged from 79.3% to 96.5% among three microbiologists.There was good interobserver (k = 0.76-0.90) and intraobserver (k = 0.70-0.97) agreements among three microbiologists.The differentiating findings (p < 0.0001) suggestive of pythium filaments were the absence of septae in 23 (79.3%) and collapsed walls in 22 (75.9%) cases.Conclusion koh + cfw has good sensitivity and specificity in the diagnosis of pythium keratitis with good interobserver and intraobserver concordance.

Journal: Indian journal of ophthalmology (2022)
Publication types: Journal Article
Does a MediDiet With Additional Extra Virgin Olive Oil and Pistachios Reduce the Incidence of Gestational Diabetes?

The present study aimed to evaluate gestational diabetes mellitus (gdm) incidence in pregnant women following the mediterranean diet (med diet) with the addition of extra virgin olive oil (evoo) and pistachios.Methods a total of 560 pregnant patients were enrolled in the present study.The med diet was introduced in both the interventional group (ig) and the control group.The women in the ig received 40 m l of evoo every day along with 25 to 30 g of roasted pistachios.The incidence of gdm was recorded along with specific maternal and neonatal outcomes.Results the nutritional scores and med diet adherence screener scores were not statistically different between the groups at baseline, but the difference was statistically significant and higher in the ig at 24 to 28 weeks (p = .001) and at 36 to 38 weeks (p = .001).Gdm was diagnosed in 51 (20.4%) women in the control group and 34 (13.6%) women in the ig.The med diet significantly reduced gdm incidence (p = .02) after adjusting for confounding factors.Conclusion the present study shows that dietary intervention in pregnant women, including a med diet and increased consumption of evoo and pistachios, decreases the incidence of gdm.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists (2022)
Publication types: Journal Article
Threats and violence towards urban bus drivers in Sweden': Drivers experiences and general recommendations to prevent violence and threats.

Approximately 30% of swedish urban bus drivers report having been exposed to threats or violence.As 50% of drivers have voiced concerns about the occurrences, threats and violence also represent contributing factors to driver stress and fatigue.Objective the aim of this study was to explore bus drivers' experience of threats and violence; how threats and violence manifests and how the problem is handled by drivers.Gaining understanding of the circumstances is important to reduce the number of threats and violent incidents to provide healthy and attractive working conditions for drivers.Methods this study is based on in-depth interviews with 12 urban bus drivers in the city of malmö in sweden.Results urban bus drivers experience threats daily from passengers, although physical violence occurs less often.The most common situations resulting in threats involve asking passengers to show valid tickets, denying child carriages onboard and running late to a bus stop.The drivers have not received clear guidelines as to strategic handling of the invalid ticket situation.Conclusions recommendations include a clear policy and consensus with regard to handling invalid tickets, providing drivers with guidelines for appropriate procedures for passengers refusing to pay, improving reporting routines and establishing a strategy for the public transportation provider and operator to follow with regard to reports, in-vehicle surveillance cameras including informing passengers that they are being video recorded as well as harmonizing the location of alarm buttons on buses.

Journal: Work (Reading, Mass.) (2022)
Publication types: Journal Article
A Comparative Analysis of Functional Status and Mobility in Stroke Patients with and without Aphasia.

All researchers agree that aphasia is a serious consequence of a stroke, but they also report contradictory data regarding the functional outcome.The aim of this study was, therefore, to assess the functional outcomes of stroke patients with and without aphasia, who were undertaking a regular rehabilitation programme.Materials and methods the study group consisted of 116 post-stroke patients, including 54 patients without aphasia (g1) and 62 patients with aphasia (g2).The following tests were used before (t1) and after (t2) rehabilitation measurement points: barthel index (bi), sitting assessment scale (sas), berg balance scale (bbs), trunk control test (tct), test up & go (tug) and the timed walk test (twt).Results the group of post-stroke patients with aphasia had a significantly longer time since a stroke on admission, a significantly longer length of stay in the ward and significantly worse sas and tct scores at t2, compared to patients without aphasia.Both groups achieved significant improvement in all studied parameters (sas, tct, bi, bbs, tug and twt).Aphasia was a predictor of functional status in the stroke patients group, but only at the time of admission to the ward.Conclusions patients with and without aphasia have an equal likelihood of improving their functional status and returning to independence.Aphasia should not be an absolute factor that excludes stroke patients from research studies on their functional status.

Journal: Journal of clinical medicine (2022)
Publication types: Journal Article
Intelligibility of Noise-Adapted and Clear Speech in Energetic and Informational Maskers for Native and Nonnative Listeners.

This study explored clear speech (cs) and noise-adapted speech (nas) intelligibility benefits for native and nonnative english listeners.It also examined how the two speaking style adaptations interact with maskers that vary from purely energetic to largely informational at different signal-to-noise ratios (snrs).Method materials consisted of 40 sentences produced by 10 young adult talkers in a conversational and a clear speaking style under two conditions: (a) in quiet and (b) in response to speech-shaped noise (ssn) played over headphones (nas).Young adult native (experiment 1) and nonnative (experiment 2) english listeners heard target sentences presented in two-talker (2t) babble, six-talker (6t) babble, or ssn and at an "easier" and a "harder" snr.Results when talkers produced cs and nas, word recognition accuracy was significantly improved for both listener groups.The largest intelligibility benefit was obtained for the cs produced in response to noise (cs+nas).Overall accuracy was highest in 2t babble.Accuracy was higher in ssn than in 6t babble for nonnative listeners at both levels of listening difficulty but only at a more difficult snr for native listeners.Listeners benefited from cs and nas most in the presence of ssn and least in 2t babble.When snrs were the same for the two listener groups, native listeners outperformed nonnative listeners in almost all listening conditions, but nonnative listeners benefited more from cs and nas in 6t babble than native listeners did.Conclusions combined speaking style enhancements, cs+nas, provided the largest intelligibility increases for native and nonnative listeners in all listening conditions.The results add to the body of evidence supporting speech-oriented, behavioral therapy techniques for maximizing speech intelligibility in everyday listening situations.

Journal: Journal of speech, language, and hearing research : JSLHR (2022)
Publication types: Journal Article
Severe acute malnutrition in children aged under 5 years can be successfully managed in a non-emergency routine community healthcare setting in Ghana.

This study investigated the performance of community-based management of severe acute malnutrition (cmam) within routine healthcare services in ghana.This was a retrospective cohort study of n = 488 children (6-59 months) who had received cmam.Data for recovery, default, and mortality rates were obtained from enrolment cards in 56 outpatient centres in upper east region, ghana.Satisfactory rates of recovery of 71.8% were reported.Children who were enrolled with higher mid-upper arm circumference (muac) ≥11.5 cm had seven times greater chance of recovery compared with children who were enrolled with lower muac <11.5 cm, or = 7.35, 95% ci [2.56, 21.15], p < .001.Children who were diagnosed without malaria at baseline were 30 times, or = 30.39, 95% ci [10.02, 92.13], p < .001, more likely to recover compared with those with malaria (p < .001).The average weight gain was 4.7 g-1·kg-1·day-1, which was influenced by muac status at baseline, β = .78, 95% ci [0.46, 1.00], p < .001, presence of malaria, β = -1.25, 95% ci [-1.58, 0.92], p < .001, and length of stay, β = 0.13, 95% ci [0.08, 0.18], p < .001.The default rate (28.5%) was higher than international standards recommendations by sphere.Mortality rate (1.6%) was lower than international standards.Our findings suggest that community-based management of sam can achieve similar success when delivered in routine non-emergency settings.However, this success can be diluted by a high default rate, and the factors contributing to this need to be explored to improve programme effectiveness within communities.

Journal: Maternal & child nutrition (2017)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A rare case of primary solitary endobronchial plasmacytoma.

Extramedullary plasmacytoma (emp) is a rare plasma cell tumor involving the organs but without bone marrow involvement or the characteristics of multiple myeloma.Primary solitary endobronchial plasmacytoma is extremely rare.Here we present the case of an 86-year-old male ex-smoker who visited our outpatient clinic for an endobronchial mass in the left upper lobe of the lung.Fiberoptic bronchoscopy revealed a protruding mass in the left upper lobar bronchus; based on the bronchoscopic biopsy findings, a primary solitary endobronchial plasmacytoma was diagnosed.After radiation therapy the patient was well and 6 months after treatment showed no evidence of disease recurrence.Extramedullary plasmacytoma should be considered in the differential diagnosis of an endobronchial mass.

Journal: Thoracic cancer (2021)
Publication types: Case Reports;Journal Article;Research Support, Non-U.S. Gov't
Behavior therapy for depressed breast cancer patients: predictors of treatment outcome.

Major depressive disorder (mdd) is the most common psychiatric disorder among breast cancer patients and is associated with substantial functional impairment.Although several outcome studies have explored the utility of psychotherapy for breast cancer patients with subsyndromal depression symptoms, only a few clinical trials have explored the efficacy of behavior therapy for patients with well-diagnosed mdd.An additional limitation of this research is that little is known about factors that best predict treatment outcome.Method in the context of a recent randomized trial of behavior activation and problem-solving therapy for depressed breast cancer patients (n = 80; hopko et al., 2011), this study explored predictors of treatment outcome with selected demographic (age, education, marital status, occupational status), psychosocial (pretreatment depression and environmental reward, coexistent anxiety disorders, social support, history of psychotherapy) and cancer-related variables (cancer stage, duration of cancer diagnosis, and cancer treatment).Results positive treatment outcome as defined by beck depression inventory-ii (beck et al., 1996) response and remission criteria was associated with being married, increased social support, not actively undergoing cancer treatment during psychotherapy, and having a history of psychotherapy.Conclusions the efficacy of behavior therapy for depressed breast cancer patients may depend on several patient variables.Implications for the provision of behavior therapy for breast cancer patients are discussed.

Journal: Journal of consulting and clinical psychology (2015)
Publication types: Journal Article;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
Fate of Patients With Intraductal Papillary Mucinous Neoplasms of Pancreas After Resection According to the Pathology and Margin Status: Continuously Increasing Risk of Recurrence Even After Curative Resection Suggesting Necessity of Lifetime Surveillance.

This study evaluated the associated factors and prognosis according to pathology and margin after surgical resection of intraductal papillary mucinous neoplasms (ipmn).Background there is limited information on recurrence patterns according to pathology and margin in ipmn.Methods total 577 patients who underwent operation for ipmn at a tertiary center were included.Factors associated with recurrence, survival, and recurrence outcomes according to pathology and margin were analyzed.Results among 548 patients analyzed, 353 had low-grade dysplasia (lgd), 78 had high-grade dysplasia (hgd), and 117 had invasive ipmn.Total 50 patients developed recurrences, with 4 resection margins, 10 remnant pancreas, 11 locoregional, and 35 distant recurrences.Invasive ipmn showed worse 5-year cumulative recurrence risk (lgd vs hgd vs invasive: 0.7% vs 4.3% vs 37.6%, p 37 ( p = 0.003), invasive ipmn ( p < 0.001), and malignant margin ( p = 0.036) were associated with recurrence.Conclusions invasive ipmn developed more recurrences and had worse survival than lgd or hgd, indicating the need for more efficient postoperative treatment strategies.Patients with lgd and hgd also need regular follow-up for recurrence after 5 years.Malignant margins need additional resection to achieve negative or at least lgd margin.

Journal: Annals of surgery (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Concurrent schedules: How responses per reinforcer affects estimates of sensitivity to reinforcement.

Conventionally, when choice is measured under concurrent schedules, all responses are included.However, the class of all responses consists of 2 sub-classes which are discriminable by their properties: reinforced responses always equal obtained reinforcers, while unreinforced responses are free to vary.As a result, the inclusion of reinforced responses in choice measures results in sensitivity values in generalized matching that are biased toward larger values, and this bias becomes extreme in some combinations of overall response and reinforcer rates.Different ways of varying concurrent-schedule values also affect estimated sensitivity and the linearity between choice based on all responses and reinforcer ratios.To avoid spurious results and comparisons, and as a matter of good practice, generalized-matching fits and measures should be done using only unreinforced responses.

Journal: Journal of the experimental analysis of behavior (2021)
Publication types: Journal Article
Effect of Commercial Yeast Starter Cultures on Cabernet Sauvignon Wine Aroma Compounds and Microbiota.

Commercial saccharomyces cerevisiae plays an important role in the traditional winemaking industry.In this study, the correlation of microbial community and aroma compound in the process of alcohol fermentation of cabernet sauvignon by four different commercial starters was investigated.The results showed that there was no significant difference in the fermentation parameters of the four starters, but there were differences in microbial diversity among the different starters.The wine samples fermented by cec01 had higher microbial abundance.Gc-ms detected a total of 58 aromatic compounds from the fermentation process by the experimental yeasts.There were 25 compounds in the f6d variant, which was higher than in other samples.The pca score plot showed that 796 and f15 yeast-fermented wines had similar aromatic characteristic compositions.According to partial least squares (pls, vip > 1.0) analysis and spearman’s correlation analysis, 11, 8, 8 and 10 microbial genera were identified as core microorganisms in the fermentation of 796, cec01, ceca and f15 starter, respectively.Among them, leuconostoc, lactobacillus, sphingomonas and pseudomonas played an important role in the formation of aroma compounds such as ethyl caprylate, ethyl caprate and ethyl-9-decenoate.These results can help us to have a better understanding of the effects of microorganisms on wine aroma and provide a theoretical basis for improving the flavor quality of cabernet sauvignon wine.

Journal: Foods (Basel, Switzerland) (2022)
Publication types: Journal Article
Alleviating excess boron stress in tomato calli by applying benzoic acid to various biochemical strategies.

Benzoic acid (ba) represents vital roles in plant activity and response to diverse unfavorable conditions.However, its participation in mitigating excess boron (eb) stress in plants is elusive.Herein, we have examined the impacts of ba (1 μm) in controlling boron (b) uptake in tomato (solanum lycopersicum l.) calli exposed to various eb levels (0, 1, 2, and 3 m m).The free, semi-bound, and bound b forms were stimulated by eb, while these forms were reduced in b-stressed calli by ba supplementation (40.37%, 36.08%, and 66.91%, respectively, less than 3 m m b-stressed calli alone).Eb caused a reduction in the uptake of potassium (k+), calcium (ca2+), magnesium (mg2+), and nitrite (no2-) while increasing the concentration of phosphorus (p), nitrate (no3-), sulfur (s), and sulfate (so42-) in b-stressed calli.Ba application induced the uptake of k+, ca2+, mg2+, no3-, s, and so42-; however, it reduced p and no2-concentrations in b-stressed calli.Eb reduced nitrate reductase activity (nr), while ba application did not alleviate this reduction.Eb treatments significantly, in most cases, increased sulfite oxidase (so) activity.Supplementation of ba along with eb further enhanced so activity.Cell wall components (cellulose, hemicellulose, and pectin) were decreased under eb treatments but considerably increased in b-stressed calli by ba application.Fourier transform infrared spectrometer (ft-ir) output showed that eb treatments with/without ba led to alterations in cell wall functional groups of calli.Our findings indicated that ba application enabled tomato callus to counteract the harmful effect of eb, leading to improved callus growth.

Journal: Plant physiology and biochemistry : PPB (2022)
Publication types: Journal Article
Noise Level inside Sri Lanka Transport Board Buses and Hearing Impairment of Long- and Short-Distance Bus Drivers of Ampara and Batticaloa Districts, Sri Lanka.

Transport drivers are more vulnerable to hearing impairment due to the traffic environment and fast-growing urbanization.Objective the study aims to determine the noise level inside the sri lanka transport board (sltb) buses, hearing impairment of state transport bus drivers, and its associated factors in the selected districts of eastern province, sri lanka.Materials and methods a cross-sectional descriptive study was carried out among 256 state bus drivers using a systematic sampling technique.A screening tool to assess the level of hearing impairment of drivers and a format to measure equivalent noise level inside the sltb buses were used to collect data.Noise measurement was done using benetech sound level meter (model db 130).Results with reference to the noise level inside buses, 88.4% (n= 53) exceeded 85 d b (a), and 21.7% of buses (n= 13) were above 90 d b (a).According to the hearing tool's hearing impairment assessment, the hearing of the majority of the study participants (84.4%,n= 216) was not affected.The association between hearing impairment and past history of ear diseases, surgeries, or head trauma was statistically significant (p= 0.017).Conclusions noise level inside the sltb buses in ampara and batticaloa districts exceeded the 85 d b limit prescribed under the who standards of occupational noise exposure.The years of service of a bus was the only factor shown a statistically significant association with the level of noise inside the bus.

Journal: Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine (2022)
Publication types: Journal Article