syedzayyan/paper_mill_benchmark huggingface dataset:
High-Availability Computing Platform with Sensor Fault Resilience.

Modern computing platforms usually use multiple sensors to report system information.In order to achieve high availability (ha) for the platform, the sensors can be used to efficiently detect system faults that make a cloud service not live.However, a sensor may fail and disable ha protection.In this case, human intervention is needed, either to change the original fault model or to fix the sensor fault.Therefore, this study proposes an ha mechanism that can continuously provide ha to a cloud system based on dynamic fault model reconstruction.We have implemented the proposed ha mechanism on a four-layer open stack cloud system and tested the performance of the proposed mechanism for all possible sets of sensor faults.For each fault model, we inject possible system faults and measure the average fault detection time.The experimental result shows that the proposed mechanism can accurately detect and recover an injected system fault with disabled sensors.In addition, the system fault detection time increases as the number of sensor faults increases, until the ha mechanism is degraded to a one-system-fault model, which is the worst case as the system layer heartbeating.

Journal: Sensors (Basel, Switzerland) (2021)
Publication types: Journal Article
Changes in phenological events in response to a global warming scenario reveal greater adaptability of winter annual compared with summer annual arabidopsis ecotypes.

And aims the impact of global warming on life cycle timing is uncertain.We investigated changes in life cycle timing in a global warming scenario.We compared arabidopsis thaliana ecotypes adapted to the warm/dry cape verdi islands (cvi), macaronesia, and the cool/wet climate of the burren (bur), ireland, northern europe.These are obligate winter and summer annuals, respectively.Methods using a global warming scenario predicting a 4 °c temperature rise from 2011 to approx.2080, we produced f1 seeds at each end of a thermogradient tunnel.Each f1 cohort (cool and warm) then produced f2 seeds at both ends of the thermal gradient in winter and summer annual life cycles.F2 seeds from the winter life cycle were buried at three positions along the gradient to determine the impact of temperature on seedling emergence in a simulated winter life cycle.Key results in a winter life cycle, increasing temperatures advanced flowering time by 10.1 d °c-1 in the winter annual and 4.9 d °c-1 in the summer annual.Plant size and seed yield responded positively to global warming in both ecotypes.In a winter life cycle, the impact of increasing temperature on seedling emergence timing was positive in the winter annual, but negative in the summer annual.Global warming reduced summer annual plant size and seed yield in a summer life cycle.Conclusions seedling emergence timing observed in the north european summer annual ecotype may exacerbate the negative impact of predicted increased spring and summer temperatures on their establishment and reproductive performance.In contrast, seedling establishment of the macaronesian winter annual may benefit from higher soil temperatures that will delay emergence until autumn, but which also facilitates earlier spring flowering and consequent avoidance of high summer temperatures.Such plasticity gives winter annual arabidopsis ecotypes a distinct advantage over summer annuals in expected global warming scenarios.This highlights the importance of variation in the timing of seedling establishment in understanding plant species responses to anthropogenic climate change.

Journal: Annals of botany (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Formulation, Characterization and Evaluation of Innovative O/W Emulsions Containing Curcumin Derivatives with Enhanced Antioxidant Properties.

In the present study, a series of semisolid oil in water (o/w) emulsions containing different curcumin (cur) derivatives (cur powder, cur extract and cur complexed with β-cyclodextrin) in varying concentrations, were prepared.Initially, dynamic light scattering (dls), microscopy, p h and viscosity measurements were performed to evaluate their stability over time.Moreover, the effect of the active cosmetic substances on the sun protection factor (spf), antimicrobial and antioxidant properties of the prepared emulsions was investigated.It was observed that emulsions containing cur extract and cur β-cyclodextrin complex presented great viscosity and p h stability for up to 90 days of storage contrary to the emulsions containing cur powder which showed unstable behavior due to the formation of agglomerates.All samples presented spf values between 2.6 and 3.2.The emulsions with cur in all forms exhibited high antioxidant activity, whereas the emulsion containing cur β-cyclodextrin complex presented the highest value.Despite their improved stability and antioxidant activity, the emulsions containing cur extract and cur-β-cyclodextrin exhibited a low percentage of antimicrobial activity against e.Coliand staphylococcusbacteria.Instead, the emulsions containing cur powder presented a reduction rate over 90 % against e.Coliand staphylococcuscolonies.

Journal: Antioxidants (Basel, Switzerland) (2022)
Publication types: Journal Article
Lactobacillus plantarum and Deoxynivalenol Detoxification: A Concise Review.

Mycotoxins are toxic secondary fungal metabolites that contaminate feeds, and their levels remain stable during feed processing.The economic impact of mycotoxins on animal production happens mainly due to losses related to direct effects on animal health and trade losses related to grain rejection.Deoxynivalenol (don) is a trichothecene mycotoxin that has contaminated approximately 60% of the grains worldwide.Ingestion of don induces many toxic effects on human and animal health.Detoxification strategies to decrease don levels in food and feeds include physical and chemical methods; however, they are not very effective when incorporated into the industrial production process.A valuable alternative to achieve this aim is the use of lactic acid bacteria.These bacteria can control fungal growth and thus overcome don production or can detoxify the mycotoxin through adsorption and biotransformation.Some lactobacillus spp.Strains, such as lactobacillus plantarum, have demonstrated preventive effects against don toxicity in poultry and swine.This beneficial effect is associated with a binding capacity of lactic acid bacteria cell wall peptidoglycan with mycotoxins.Moreover, several antifungal compounds have been isolated from l.Plantarum supernatants, including lactic, acetic, caproic, phenyl lactic, 3-hydroxylated fatty, and cyclic dipeptide acids.Biotransformation of don by l.Plantarum into other products is also hypothesized, but the mechanism remains unknown.In this concise review, we highlight the use of l.Plantarum as an alternative approach to reduce don levels and toxicity.Although the action mechanism of l.Plantarum is still not fully understood, these bacteria are a safe, efficient, and low-cost strategy to reduce economic losses from mycotoxin contamination cases.Highlights

Journal: Journal of food protection (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Multi-Modal Diagnosis of Infectious Diseases in the Developing World.

In low and middle income countries, infectious diseases continue to have a significant impact, particularly amongst the poorest in society.Tetanus and hand foot and mouth disease (hfmd) are two such diseases and, in both, death is associated with autonomic nervous system dysfunction (ansd).Currently, photoplethysmogram or electrocardiogram monitoring is used to detect deterioration in these patients, however expensive clinical monitors are often required.In this study, we employ low-cost and mobile wearable devices to collect patient vital signs unobtrusively; and we develop machine learning algorithms for automatic and rapid triage of patients that provide efficient use of clinical resources.Existing methods are mainly dependent on the prior detection of clinical features with limited exploitation of multi-modal physiological data.Moreover, the latest developments in deep learning (e.g.Cross-domain transfer learning) have not been sufficiently applied for infectious disease diagnosis.In this paper, we present a fusion of multi-modal physiological data to predict the severity of ansd with a hierarchy of resource-aware decision making.First, an on-site triage process is performed using a simple classifier.Second, personalised longitudinal modelling is employed that takes the previous states of the patient into consideration.We have also employed a spectrogram representation of the physiological waveforms to exploit existing networks for cross-domain transfer learning, which avoids the laborious and data intensive process of training a network from scratch.Results show that the proposed framework has promising potential in supporting severity grading of infectious diseases in low-resources settings, such as in the developing world.

Journal: IEEE journal of biomedical and health informatics (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Two-photon saturable absorption properties and laser Q-switch application of carbon quantum dots.

In this letter, high-quality carbon quantum dots (c-qds) with an average size of 15 nm are synthesized by using a solvothermal method.A c-qd saturable absorber mirror (sam) was prepared, characterized, and employed as an ultrafast optical switch successfully in a 1.0 μm solid-state laser.The saturable absorption effect (at 1 μm) far away from the linear absorption band of the c-qds could be attributed to two-photon saturable absorption, which has a native characteristic of wavelength selectivity.The modulation depth (δt) and saturable energy intensity (φs) of the c-qd-sa was measured to be about 4% and 15.34 w/mm2, respectively.By using this sa, a q-switched nd:gd vo4laser at 1 μm were first realized with the shortest pulse width of 66.8 ns and a maximum repetition rate of 1.13 mhz, respectively.The results indicate that c-qds may found to be a decent carbon sa material for the high-repetition-rate pulsed laser applications.

Journal: Optics letters (2017)
Publication types: Journal Article
Theory convergence in emotion science is timely and realistic.

Over the last century, emotion research has been beset by the problem of major disagreements with respect to the definition of the phenomenon and an abundance of different theories.Arguably, these divergences have had adverse effects on theory development, on the theoretical foundations of empirical research, and on knowledge accumulation in the study of emotion.Similar problems have been encountered in other areas of behavioural science.Increasingly, there have been calls to work towards some form of theory integration.In contrast, here an effort is made to show that a reasonable degree oftheory convergencein the area of emotion science can be attained by adopting a design feature-based working definition of emotion and highlighting the basic agreement on the components of the dynamic emotion process.The aim is to invite constructive discussion on communalities and divergences between different theories and foster the development of more complementary theoretical frameworks to guide future empirical research.

Journal: Cognition & emotion (2022)
Publication types: Journal Article
Mapping the progress of the process: Codevelopment of the therapeutic alliance with maltreated adolescents.

We used a longitudinal actor-partner interdependence model to examine the codeveloping alliance in alliance empowerment therapy (aet; escudero, 2013), a manualized team-based approach developed in spain specifically for child welfare-involved youth.In this first evaluation of aet, we sampled 102 adolescents, 83% of whom had been removed from their homes due to abuse or neglect, and 40% of whom were in crisis at the time of referral.Before each session, clients rated their improvement-so-far; after each session, both clients and therapists completed a brief alliance measure, an adaptation of the system for observing family therapy alliances (softa-s; friedlander et al., 2006) for individual therapy.In terms of outcome, clients' improvement ratings were significantly associated with posttreatment changes in overall functioning and personal goal attainment.With respect to the change process, growth was observed in both clients' and therapists' ratings of the alliance over 12 sessions, and an increased similarity in alliance ratings was due to more rapid growth in the therapists' ratings than the clients' ratings.Dynamic structural equation modeling indicated that at higher levels of adolescent goal attainment, a stronger association was observed between increased therapist-rated alliance and goal attainment.In other words, in the most effective cases, therapists were more responsive to how the adolescents seemed to have experienced the alliance in the previous session.The cocreated alliance perceptions were due to therapist (rather than client) responsiveness, as well as to unspecified aspects of sharing a therapy environment over time, such as familiarity with the process, regular meetings, and so on.(psyc info database record (c) 2022 apa, all rights reserved).

Journal: Journal of counseling psychology (2022)
Publication types: Journal Article
To Assess the Effect of Trauma on the Temporomandibular Joint in Postoperative Cases of Zygomaticomaxillary Complex Fractures.

And objectives the study aims to assess the incidence and features of temporomandibular joint(tmj) dysfunction in post-surgical treatment of unilateral zygomaticomaxillary complex(zmc) fractures.the objectives are:to assess severity of tmj dysfunction in postoperative cases of zmc fractures.to create awareness of the same among clinicians.Methods patients presenting with zygomaticomaxillary complex fractures were evaluated prospectively.Evaluation of tmj dysfunction was done by different parameters via questionnaire, clinical and radiographic examination preoperatively and a follow-up period of 1 week, 3 months and 6 months.The parameters were, clicking of joint, pain on opening /closing, pain on biting, deviation of mandible, pain in the preauricular region, ringing sound and mouth opening.Statistical analysis was done by the friedman test and post hoc analysis.Results on presentation, 69.1% patients diagnosed with zmc fractures presented with symptoms related to tmj dysfunction.Post-surgery 1 week majority findings persisted, with 21 patients complained of pain on opening or closing and 2 patients with a persistent opening click.These symptoms, however, decreased over the 3 month and 6 month follow up period.5 patients presented with decreased mouth opening which was attributed to lack of adequate physiotherapy.Conclusion patients presented with mild symptoms of tmj dysfunction until 6 months post-surgery, however these symptoms weren't significant as the pain score assessed was found to decrease in the following post-operative periods.And the symptoms present were'nt exclusive to conclude a tmj dysfunction.Early treatment and a close follow up are key to prevent progression of symptoms.

Journal: Journal of maxillofacial and oral surgery (2022)
Publication types: Journal Article
Efficacy and safety of elagolix with add-back therapy in women with uterine fibroids and coexisting adenomyosis.

To determine if coexisting adenomyosis limits the efficacy of elagolix, an oral gonadotropin-releasing hormone antagonist, with hormonal add-back therapy in reducing heavy menstrual bleeding in women with uterine fibroids.Design pooled analysis of two identical, double-blind, randomized, placebo-controlled, 6-month phase 3 trials (elaris uterine fibroids [uf]-1 and uf-2).Setting a total of 153 gynecological clinical care settings in the united states and canada.Patients premenopausal women (18-51 years) with >80 m l of menstrual blood loss (mbl)/cycle and uterine fibroids with and without coexisting adenomyosis diagnosed by ultrasound and/or magnetic resonance imaging at baseline.Interventions participants were randomized 1:1:2 to placebo, elagolix 300 mg twice daily alone, or elagolix 300 mg twice daily with estradiol 1 mg/norethindrone acetate 0.5 mg once daily.Main outcome measures the primary endpoint was the proportion of women who had <80 m l of mbl during the final month and ≥50% reduction in mbl from baseline to the final month.Adverse events were monitored.Results of 786 women treated across the two trials, 16% (126 women) had coexisting adenomyosis.Among this subset, a significantly greater proportion of women who received elagolix with add-back therapy (77.1% [95% confidence interval, 66.2, 88.0]) met both primary endpoint criteria compared with women who received placebo (12.2% [95% confidence interval, 1.0, 23.4]).Adverse events most frequently reported in the elagolix with add-back adenomyosis subset were hot flushes (18.3%), nausea (11.7%), and night sweats (8.3%).Conclusions elagolix with add-back therapy significantly reduced heavy menstrual bleeding in women with uterine fibroids and coexisting adenomyosis, suggesting that elagolix efficacy was not adversely affected by the presence of adenomyosis (elaris uf-1 and uf-2 clinical-trials.gov numbers, nct02654054 and nct02691494).

Journal: F&S reports (2021)
Publication types: Journal Article
A predictive model of offspring congenital heart disease based on maternal risk factors during pregnancy: a hospital based case-control study in Nanchong City.

Based on epidemiological field data, this study was to develop a prediction model which can be used as a preliminary screening tool to identify pregnant women who were at high risk of offspring congenital heart disease (chd) in nanchong city, and be beneficial in guiding prenatal management and prevention.methods:a total of 367 children with chd and 367 children without congenital malformations aged 0 to 14 years old were recruited from the affiliated hospital of north sichuan medical college and nanchong central hospital between march 2016 and november 2018.Using the spss 22.0 case-control matching module, the controls were matched to the cases at a rate of 1:1, according to the same gestational age of child (premature delivery or full-term), the maternal age of pregnancy (less than 1 year).327 matched case-control pairs were analyzed by spss 22.Univariate and multivariate analysis were performed to find the important maternal influencing factors of offspring chd.A logistic regression disease prediction model was constructed as the final predictors, and hosmer-lemeshow goodness of fit test and receiver operating characteristic (roc) curve were used to evaluate the model.results:654 subjects (327 cases and 327 controls) were matched.The 25 variables were analysed.The logistic regression model established in this study was as follows: logit(p)= -2.871+(0.686×respiratory infections)+(1.176×water pollution)+(1.019×adverse emotions during pregnancy) - (0.617×nutrition supplementation).The hosmer-lemeshow chi-square value was 7.208 (df = 6), with a nonsignificant p value of 0.302, which indicates that the model was well-fitted.The calibration plot showed good agreement between the bias-corrected prediction and the ideal reference line.Area under the roc curve was 0.72 (95% ci: 0.681~0.759), which means that the predictive power of the model set fitted the data.conclusion:in nanchong city, more attention should be paid to mother who had a history of respiratory infections, exposure to polluted water, adverse emotions during pregnancy and nutritional deficiency.The risk model might be an effective tool for predicting of the risk of chd in offspring by maternal experience during pregnancy, which can be used for clinical practise in nanchong area.

Journal: International journal of medical sciences (2020)
Publication types: Journal Article;Multicenter Study;Observational Study
Human Behavior-Inspired Linchpin-Directed Catalysis for Traceless Precision Labeling of Lysine in Native Proteins.

The complex social ecosystem regulates the spectrum of human behavior.However, it becomes relatively easier to understand if we disintegrate the contributing factors, such as locality and interacting partners.Interestingly, it draws remarkable similarity with the behavior of a residue placed in a social setup of functional groups in a protein.Can it inspire principles for creating a unique environment for the precision engineering of proteins?We demonstrate that localization-regulated interacting partner(s) could render precise and traceless single-site modification of structurally diverse native proteins.The method targets a combination of high-frequency lys residues through an array of reversible and irreversible reactions.However, excellent simultaneous control over chemoselectivity, site selectivity, and modularity ensures that the user-friendly protocol renders acyl group installation, including post-translational modifications (ptms), on a single lys.Besides, it offers a chemically orthogonal handle for the installation of probes.Also, a purification protocol integration delivers analytically pure single-site tagged protein bioconjugates.The precise labeling of a surface lys residue ensures that the structure and enzymatic activities remain conserved post-bioconjugation.For example, the precise modification of insulin does not affect its uptake and downstream signaling pathway.Further, the method enables the synthesis of homogeneous antibody-fluorophore and antibody-drug conjugates (afc and adc; k183 and k249 labeling).The trastuzumab-rhodamine b conjugate displays excellent serum stability along with antigen-specific cellular imaging.Further, the trastuzumab-emtansine conjugate offers highly specific antiproliferative activity toward her-2 positive skbr-3 breast cancer cells.This work validates that disintegrate theory can create a comprehensive platform to enrich the chemical toolbox to meet the technological demands at the chemistry, biology, and medicine interface.

Journal: Bioconjugate chemistry (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Mobility of insecticide residues and main intermediates in a clay-loam soil, and impact of leachate components on their photocatalytic degradation.

This work assesses the behavior (adsorption, degradation and leaching) of four insecticides (chlorantraniliprole, thiametoxam, imidacloprid and pirimicarb) and their main reaction intermediates in a clay-loam textured soil (1.6% om).Following the batch equilibrium method, the koc(as log values) ranged from 1.2 to 3.9 (thiametoxam and pirimicarb, respectively).All the insecticides were moderately persistent (t1⁄2= 39-100 days) in the following order: thiametoxam > imidacloprid > pirimicarb > chlorantraniliprole.Two major transformation products, desmethyl-formamido pirimicarb and desmethyl pirimicarb, were formed as consequence of dealkylation of the parent compound.Using disturbed soil columns only thiametoxam (93% of the initial amount) and imidacloprid (42% of the initial amount) were recovered from leachates.In the case of pirimicarb and chlorantraniliprole, 74% and 30%, respectively, were recovered from the soil.Thiametoxam and imidacloprid can be catalogued as mobile compounds, while pirimicarb and chlorantraniliprole are classified as immobile according to the screening indices used (gus and eli).Leachates containing thiametoxam and imidacloprid were subjected to photocatalytic treatment for 240 min using ti o2/na2s2o8with the help of a photochemical reactor equipped with led lamp.Both compounds had a very fast degradation rate (half-lives ≤ 0.5 min) in deionized water, while their half-lives were 112 min and 178 min, respectively, in leaching water.This implies a strong effect of the water matrix composition, mainly due to organic matter dissolved (quenching).Only traces of thiametoxam urea and hydroxy imidacloprid were detected during the photocatalytic experiment.

Journal: Chemosphere (2021)
Publication types: Journal Article