syedzayyan/paper_mill_benchmark huggingface dataset:
Patient's perception of recovery after osteotome-mediated sinus floor elevation with Bio-Oss collagen compared with no grafting material: a randomized single-blinded controlled trial.

Osteotome-mediated sinus floor elevation with or without a grafting material is associated with high implant survival, intrasinus bone gain, and low frequency of complications.However, patient's perception of recovery and satisfaction with the surgical intervention are rarely reported.The objective of the present randomized controlled trial was to assess patient's perception of recovery after osteotome-mediated sinus floor elevation with bio-oss collagen compared with no grafting material.Forty healthy patients were randomly allocated to bio-oss collagen or no grafting material.Oral health-related quality of life was assessed by oral health impact profile-14 at enrollment.Patient's perception of recovery was assessed by self-administrated questionnaires and visual analog scale evaluating pain, social and working isolation, physical appearance, duration and quality of life alterations, eating and speaking ability, diet variations, and sleep impairment after 1 week and 1 month, respectively.Descriptive statistics was expressed as mean percentage with standard deviation.Correlation between impaired oral health-related quality of life, age, gender, and recovery were assessed by t test.Level of significance was 0.05.Results osteotome-mediated sinus floor elevation is associated with high patient satisfaction, limited postoperative discomfort, and willingness to undergo similar surgery.Influence on patient's daily life activities seems to be minimal and limited to the first postoperative days.Most patients managed to return to work and their routine daily activities after 0-2 days.Impaired preoperative oral health-related quality of life, gender, or younger age seems not to predispose for delayed recovery.However, number of days with pain, eating difficulties, and sleep disturbances were significantly increased with bio-oss collagen compared with no grafting material (p<0.05).Conclusion patient's discomfort seems to be minimal and limited to the first postoperative days following osteotome-mediated sinus floor elevation with or without a grafting material.Impaired preoperative oral health-related quality of life, gender, or younger age seems not to predispose for delayed recovery.

Journal: International journal of implant dentistry (2021)
Publication types: Journal Article;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
A Longitudinal Analysis of the Internal Rotation and Shift (IRO/Shift) Test Following Arthroscopic Repair of Superior Rotator Cuff Lesions.

Although the use of clinical tests to diagnose superior rotator cuff pathology is common, there is paucity in the research regarding the accuracy of such tests following arthroscopic repair.The aim of this study was to determine the accuracy of the iro/shift test compared to the jobe test at 3 months and 6 months post-surgery for superior rotator cuff repair.Arthroscopic repair was conducted on 51 patients who were subsequently seen for clinical evaluation at 3 and 6 months following surgery.At 3 months post-surgery only 27% of the patients had a negative iro/shift test and 18% had a negative jobe test.However, at 6 months 88% of the patients presented with a negative iro/shift test and 61% a negative jobe test.When compared to each other, the iro/shift test and the jobe test had 90% agreement pre-operatively, 71% agreement at 3 months post-surgery, and 67% agreement at 6 months.These results demonstrate that the accuracy of the iro/shift test and the jobe test improved between 3 and 6 months following arthroscopic surgery of the superior rotator cuff, with the iro/shift test having better accuracy.

Journal: Journal of personalized medicine (2022)
Publication types: Journal Article
Electron Spin Relaxation of Tb3+and Tm3+Ions.

Electron spin relaxation times t1and tmof tb3+and tm3+in 1:1 water:ethanol and of tb3+doped (2%) in crystalline la2(oxalate)3decahydrate were measured between about 4.2 and 10 k.Both cations are non-kramers ions and have j = 6 ground states.Echo-detected spectra are compared with cw spectra and with field-stepped direct-detected epr spectra.Due to the strong temperature dependence of t1, measurements were not made above 10 k.Between about 4.2 and 6 k t1is strongly concentration dependent between 1 and ~50 m m.T1values at 4.2 k are in the μs range which is orders of magnitude faster than for 3d transition metals.Phase memory times, tm, are less than 500 ns, which is short relative to values observed for 3d transition metals and organic radicals at 4 k.Tmis longer in the oxalate lattice which is attributed to the lower proton concentration in oxalate than in the organic solvent, which decreases nuclear spin diffusion.The rigidity of the crystalline lattice also may contribute to longer tm.

Journal: Applied magnetic resonance (2020)
Publication types: Journal Article
Infectious Bronchitis Virus Evolution, Diagnosis and Control.

Rna viruses are characterized by high mutation and recombination rates, which allow a rapid adaptation to new environments.Most of the emerging diseases and host jumps are therefore sustained by these viruses.Rapid evolution may also hinder the understanding of molecular epidemiology, affect the sensitivity of diagnostic assays, limit the vaccine efficacy and favor episodes of immune escape, thus significantly complicating the control of even well-known pathogens.The history of infectious bronchitis virus (ibv) fits well with the above-mentioned scenario.Despite being known since the 1930s, it still represents one of the main causes of disease and economic losses for the poultry industry.A plethora of strategies have been developed and applied over time, with variable success, to limit its impact.However, they have rarely been evaluated objectively and on an adequate scale.Therefore, the actual advantages and disadvantages of ibv detection and control strategies, as well as their implementation, still largely depend on individual sensibility.The present manuscript aims to review the main features of ibv biology and evolution, focusing on their relevance and potential applications in terms of diagnosis and control.

Journal: Veterinary sciences (2020)
Publication types: Journal Article;Review
Sagittal Band Injuries: A Review and Modification of the Classification System.

Sagittal band injuries, although relatively uncommon, can be difficult to treat.This review provides a contemporary perspective on this pathology, as well as a modification to the classification system.This modification aims to incorporate the spectrum of disease seen, guide treatment, and allow standardization when documenting and describing injuries.

Journal: The Journal of hand surgery (2022)
Publication types: Journal Article;Review
Laparoscopically guided transversus abdominis plane block offers better pain relief after laparoscopic cholecystectomy: results of a triple blind randomized controlled trial.

Transversus abdominis plane (tap) block is a regional anaesthetic technique providing analgesia to the parietal peritoneum, muscles and skin of the anterior abdominal wall innervated by somatic nerves t6 to l1.We present the results of our randomized triple blind study comparing laparoscopically guided tap block with the commonly used port site local anaesthetic infiltration for pain relief after laparoscopic cholecystectomy.Methods a hundred patients with symptomatic gallstones planned for laparoscopic cholecystectomy were randomized into two groups of tap block and port site infiltration.Group a received 4-quadrant tap block with 10 ml of 0.25% bupivacaine at each of the four sites guided laparoscopically and port site infiltration with 10 ml of normal saline at each of the 4 ports for blinding the surgeon.Group b received port site infiltration with 0.25% bupivacaine, and infiltration with normal saline at tap block sites for blinding the surgeon.Post-operative pain (at 3, 6, 24 h and 1-week post-operative) (vas), time to return to activities of daily living and patient satisfaction (capuzzo score) were recorded by an observer blinded towards the groups of the patients.Results the median vas at 3, 6, 24 h, at discharge, and 1-week post-operative were lesser in group a compared to group b (p ≤ 0.001 for all).The median duration of hospital stay was also lesser in group a compared to group b (p = 0.48, not significant) as was the time to return to activities (p < 0.05).The median capuzzo score was higher in group a compared to group b (p < 0.001).Conclusion this study shows that laparoscopically guided tap block is a safe and easy-to-use technique.It reduces the severity of post-operative pain, helps in quick recovery, early discharge and improved patient satisfaction after laparoscopic cholecystectomy.Clinical trials registry of india 020227.

Journal: Surgical endoscopy (2021)
Publication types: Journal Article;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
Effect of Paprika Xanthophyll Supplementation on Cognitive Improvement in a Multitasking Exercise: A Pilot Study for Middle-Aged and Older Adults.

Ingestion of paprika xanthophyll supplement (px), which has antioxidant effects, has been recently reported to maintain red blood cell deformability and improve oxygen delivery efficiency.Therefore, we hypothesized that the brain activation induced by multitasking exercise in middle-aged and older participants along with the improved erythrocyte oxygen-carrying efficiency induced by px supplementation would show a synergistic effect, increasing oxygen supply to the brain and improving cognitive function more effectively.In study 1, cerebral blood flow measurements were conducted during the multitasking exercise and cognitive function tests to verify their effect on cognitive function.The results confirmed that cerebral blood flow increased during the exercise and cognitive function improved after the exercise.In study 2, we compared the effects of the multitasking exercise on cognitive function before and after px supplementation in middle-aged and older participants to evaluate the effects of px supplementation.The results suggested that px supplementation enhanced the effects of active multitasking exercise on cognitive function.We speculate that the improvement of oxygen transport efficiency by px resulted in more effective oxygen supply, allowing the multitasking exercise to occur more effectively, which was reflected as an improvement in the cognitive function.

Journal: Healthcare (Basel, Switzerland) (2022)
Publication types: Journal Article
RNAi-mediated knockdown of PFK1 decreases the invasive capability and metastasis of nasopharyngeal carcinoma cell line, CNE-2.

Nasopharyngeal carcinoma (npc) is the most prevailing malignancy of the head and neck with unique geographic distribution.Southern china has one of the highest incidence rates of npc in the world.Although radiotherapy and chemotherapy are the most important treatment modalities for npc, recurrence, and metastasis severely interfere with the survival quality of patients.It is much-needed to find an effective method of npc treatment with a good prognosis such as gene therapy.Pfk1, a key regulatory enzyme of glycolysis, is frequently shown to be amplified and overexpressed in a variety of human cancers.However, the function of pfk1 and molecular mechanism in npc is elusive.Here, we knockdown pfk1 expression by utilizing dna vector-based rna interference.Western blotting and real-time pcr show that the expression of pfk1 is efficiently down-regulated in both protein and m rna levels by stable transfection with pfk1 si rna expression vector.In addition, stable knockdown of pfk1 expression inhibits cell growth, induces apoptosis, decreases the invasive capability and metastasis in the cne2 human npc cell line.This present study finds the importance of pfk1 which can be worked as a novel target in npc treatment and holds great potential to be extended to other malignant cancers.

Journal: Cell cycle (Georgetown, Tex.) (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
To Be, or Not to Be, an Inhibitor: A Comparison of Azole Interactions with and Oxidation by a Cytochrome P450 Enzyme.

The cytochrome p450 (cyp) superfamily of heme monooxygenases is involved in a range of important chemical biotransformations across nature.Azole-containing molecules have been developed as drugs that bind to the heme center of these enzymes, inhibiting their function.The optical spectrum of cyp enzymes after the addition of these inhibitors is used to assess how the molecules bind.Here we use the bacterial cyp199a4 enzyme, from rhodopseudomonas palustris ha a2, to compare how imidazolyl and triazolyl inhibitors bind to ferric and ferrous heme.4-(imidazol-1-yl)benzoic acid induced a red shift in the soret wavelength (424 nm) in the ferric enzyme along with an increase and a decrease in the intensities of the δ and α bands, respectively.4-(1h-1,2,4-triazol-1-yl)benzoic acid binds to cyp199a4 with a 10-fold lower affinity and induces a smaller red shift in the soret band.The crystal structures of cyp199a4 with these two inhibitors confirmed that these differences in the optical spectra were due to coordination of the imidazolyl ligand to the ferric fe, but the triazolyl inhibitor interacts with, rather than displaces, the ferric aqua ligand.Additional water molecules were present in the active site of 4-(1h-1,2,4-triazol-1-yl)benzoic acid-bound cyp199a4.The space required to accommodate these additional water molecules in the active site necessitates changes in the position of the hydrophobic phenylalanine 298 residue.Upon reduction of the heme, the imidazole-based inhibitor fe-n ligation was not retained.A 5-coordinate heme was also the predominant species in 4-(1h-1,2,4-triazol-1-yl)benzoic acid-bound ferrous cyp199a4, but there was an obvious shoulder at 447 nm indicative of some degree of fe-n coordination.Rather than inhibit cyp199a4, 4-(imidazol-1-yl)benzoic acid was a substrate and was oxidized to generate a metabolite derived from ring opening of the imidazolyl ring: 4-[[2-(formylamino)acetyl]amino]benzoic acid.

Journal: Inorganic chemistry (2022)
Publication types: Journal Article;Comparative Study
Pharyngeal bulb prosthesis and speech outcome in patients with cleft palate.

Introduction individuals with cleft palate can present with velopharyngeal dysfunction after primary palatoplasty and require a secondary treatment due to insufficiency.In these cases, the pharyngeal bulb prosthesis can be used temporarily while awaiting secondary surgery.Objective this study aimed to investigate the outcome of treatment of hypernasality with pharyngeal bulb prosthesis in patients with history of cleft palate presenting with velopharyngeal insufficiency after primary palatal surgery.We hypothesized that the use of the pharyngeal bulb prosthesis is an effective approach to eliminate hypernasality related to velopharyngeal insufficiency in patients with cleft palate.Methods thirty speakers of brazilian portuguese (15 males and 15 females) with operated cleft palate, ages ranging from 6 to 14 years (mean: 9 years; sd = 1.87 years), participated in the study.All patients were fitted with a pharyngeal bulb prosthesis to manage velopharyngeal insufficiency while they were awaiting corrective surgery to be scheduled.Auditory-perceptual analysis of speech recorded in the conditions with and without pharyngeal bulb prosthesis were obtained from three listeners who rated the presence or absence of hypernasality for this study.Results seventy percent of the patients eliminated hypernasality while employing the pharyngeal bulb prosthesis, while 30% still presented with hypernasality.The comparison was statistically significant (p < 0.001).Conclusion the use of the pharyngeal bulb prosthesis is an effective approach to eliminate hypernasality related to velopharyngeal insufficiency.

Journal: Brazilian journal of otorhinolaryngology (2022)
Publication types: Journal Article
Targeted drug delivery systems: synthesis and in vitro bioactivity and apoptosis studies of gemcitabine-carbon dot conjugates.

Gemcitabine (gem) is used to treat various cancers such as breast, pancreatic, non-small lung, ovarian, bladder, and cervical cancers.Gem, however, has the problem of non-selectivity.Water-soluble, fluorescent, and mono-dispersed carbon dots (cds) were fabricated by ultrasonication of sucrose.The cds were further conjugated with gem through amide linkage.The physical and morphological properties of these carbon dot-gemcitabine (cd-gem) conjugates were determined using different analytical techniques.In vitro cytotoxicity and apoptosis studies of cd-gem conjugates were evaluated by various bioactivity assays on human cell lines, mcf-7 (human breast adenocarcinoma), and he la (cervical cancer) cell lines.The results of kinetic studies have shown a maximum drug loading efficacy of 17.0 mg of gem per 50.0 mg of cds.The cds were found biocompatible, and the cd-gem conjugates exhibited excellent bioactivity and exerted potent cytotoxicity against tumor cells with an ic50value of 19.50 μg ml-1in he la cells, which is lower than the ic50value of pure gem (∼20.10 μg ml-1).In vitro studies on cd-gem conjugates demonstrated the potential to replace the conventional administration of gem.Cd-gem conjugates are more stable, have a higher aqueous solubility, and are more cytotoxic as compared to gem alone.The cd-gem conjugates show reduced side effects in the normal cells along with excellent cellular uptake.Hence, cd-gem conjugates are more selective toward cancerous cell lines as compared to non-cancerous cells.Also, the cd-gem conjugates successfully induced early and late apoptosis in cancer cell lines and might be effective and safe to use for in vivo applications.

Journal: Biomedical materials (Bristol, England) (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Commentary: A pathway forward for implementation science in the search to accelerate the delivery of effective mental health treatment and services for youth: reflections on Williams and Beidas (2019).

Over the past several decades, implementation science has emerged as a promising new field designed to reduce the gap between research and practice.One population that has not fully benefitted from recent efforts to implement evidence-based mental health treatment and services are children and adolescents.In the review by williams and beidas, the authors provide a thoughtful discussion on where the implementation science field has previously been within the area of child psychology and psychiatry, identified the scientific limitations of prior phases or 'waves' in the historical development of implementation science, and recommend where the field needs to go - by underscoring the importance of developing and testing multilevel, integrated causal theories and mechanism-based approaches.This commentary draws attention to the importance of the perspectives and recommendations proposed in this review, which offer the potential to generate new advances in the field of implementation science that will ultimately, improve mental health care and clinical outcomes for youth.

Journal: Journal of child psychology and psychiatry, and allied disciplines (2019)
Publication types: Journal Article;Comment
Consolidation of the clinical and genetic definition of aSOX4-related neurodevelopmental syndrome.

A neurodevelopmental syndrome was recently reported in four patients with sox4heterozygous missense variants in the high-mobility-group (hmg) dna-binding domain.The present study aimed to consolidate clinical and genetic knowledge of this syndrome.Methods we newly identified 17 patients with sox4variants, predicted variant pathogenicity using in silico tests and in vitro functional assays and analysed the patients' phenotypes.Results all variants were novel, distinct and heterozygous.Seven hmg-domain missense and five stop-gain variants were classified as pathogenic or likely pathogenic variant (l/pv) as they precluded sox4 transcriptional activity in vitro.Five hmg-domain and non-hmg-domain missense variants were classified as of uncertain significance (vus) due to negative results from functional tests.When known, inheritance was de novo or from a mosaic unaffected or non-mosaic affected parent for patients with l/pv, and from a non-mosaic asymptomatic or affected parent for patients with vus.All patients had neurodevelopmental, neurological and dysmorphic features, and at least one cardiovascular, ophthalmological, musculoskeletal or other somatic anomaly.Patients with l/pv were overall more affected than patients with vus.They resembled patients with other neurodevelopmental diseases, including the sox11-related and coffin-siris (css) syndromes, but lacked the most specific features of css.Conclusion these findings consolidate evidence of a fairly non-specific neurodevelopmental syndrome due to sox4haploinsufficiency in neurogenesis and multiple other developmental processes.

Journal: Journal of medical genetics (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
"Tuned into a different channel": Autistic transgender adults' experiences of intersectional stigma.

In this critical-constructivist grounded theory study, we interviewed 13 autistic-transgender, nonbinary, and/or gender diverse (tng) individuals on the intersection of their autistic-tng identities and how they resisted marginalization related to these experiences.Analysis revealed the experiences of living in a world that "doesn't seem quite set up the right way" and situated autistic-tng experiences in complex set of intersectional processes that require navigating relationships, health care systems, and safety challenges living in a heterosexist, cissexist, and ableist society.Participants had to constantly assess the safety and disclosure of their identities in the face of oppressive systems while claiming space and creating community that affirmed them.We conclude by highlighting the importance of taking an intersectional lens to highlight the many positive aspects of being autistic and tng, which have been largely absent in research and clinical dialogues.We provide some suggestions for providing culturally responsive mental health and ways neurotypical and cisgender people can begin to challenge ableist and cissexist narratives in their clinical practice and research, alongside autistic-tng people.(psyc info database record (c) 2022 apa, all rights reserved).

Journal: Journal of counseling psychology (2022)
Publication types: Journal Article