syedzayyan/paper_mill_benchmark huggingface dataset:
Can green trade save the environment? Introducing the Green (Trade) Openness Index.

Environmental degradation is one of the main drivers of climate change.One of the most broadly accepted tools to minimize environmental degradation is the introduction of "green products".This paper introduces the "green trade openness index" to (a) measure the importance of green products in a region and (b) revisit the trade-environment nexus in a sample study of 31 oecd countries over the period 2007-2017.The empirical analysis confirms the environmental kuznets curve hypothesis and - more importantly - demonstrates for the first time that the presence of green products in a country's trade basket reduces that country's ecological footprint.This is essential information for practitioners and policy makers looking for a pathway to sustainable development.Finally, the novel index creates opportunities for future research, as the index can be used as explanatory variable in different research questions and fields of research.

Journal: Environmental science and pollution research international (2022)
Publication types: Journal Article
Single-Vendor Electronic Health Record Use Is Associated With Greater Opportunities for Organizational and Clinical Care Improvements.

To compare how hospitals that use single-vendor vs best-of-breed electronic health record (ehr) vendors utilize clinical and organizational evaluation capabilities.Methods data from the 2018 (june 1, 2016, to december 31, 2017) american hospital association information technology supplement survey and medicare final rule standardizing file were used.Multinomial logistic regression analysis of hospitals (n=1902) was conducted to identify hospital characteristics associated with the use of ehrs for (1) clinical care evaluation capabilities and (2) organizational evaluation capabilities.Results single-vendor ehr hospitals were more likely (relative risk ratio, 3.37; 95% confidence interval, 1.97-5.76) to use ehrs for clinical care and organizational evaluation capabilities.Not-for-profit hospitals were more likely to use ehrs for all organizational evaluation capabilities than government nonfederal hospitals.For-profit hospitals were less likely to use ehrs for organizational or clinical evaluation capabilities than government nonfederal hospitals.Conclusion hospitals using the single-vendor ehr system were more likely to engage in clinical care and organizational evaluation than hospitals using best-of-breed ehr systems.

Journal: Mayo Clinic proceedings. Innovations, quality & outcomes (2022)
Publication types: Journal Article
Impact of Cabozantinib Exposure on Proteinuria and Muscle Toxicity in Patients with Unresectable Hepatocellular Carcinoma.

This prospective study investigated the impact of cabozantinib exposure on proteinuria and muscle toxicity, in a cohort of 14 japanese patients with unresectable hepatocellular carcinoma (u hcc).We measured the trough concentration of cabozantinib (ctrough) weekly for 6 weeks after starting treatment.Although the initial dose was less than 60 mg in most cases, dose interruption occurred in 79%, primarily because of proteinuria and/or malaise.The median and coefficient of variation of maximum ctrough at 7−42 d were 929.0 ng/m l and 59.2%, respectively.The urinary protein-to-creatinine ratio (upcr), serum creatine kinase, and serum aldolase values were all significantly elevated following treatment.Moreover, maximum changes in serum creatine kinase and aldolase were significantly associated with maximum ctrough (r = 0.736, p < 0.01; r = 0.798, p < 0.001; respectively).Receiver operating characteristic (roc) curve analysis showed that changes in serum creatine kinase ≥70.5 u/l and aldolase ≥6.1 u/l from baseline relatively accurately predicted inclusion in the high-maximum ctrough (≥929.0 ng/m l) group, with an area under the roc of 0.929 and 0.833, respectively.Measurement of serum creatine kinase and aldolase may increase the clinical usefulness of cabozantinib treatment for u hcc and help alleviate difficulties with dose adjustments.

Journal: Pharmaceuticals (Basel, Switzerland) (2022)
Publication types: Journal Article
Predicting outcomes for locally advanced rectal cancer treated with neoadjuvant chemoradiation with CT-based radiomics.

A feasibility study was performed to determine if ct-based radiomics could play an augmentative role in predicting neoadjuvant rectal score (nar), locoregional failure free survival (lrffs), distant metastasis free survival (dmfs), disease free survival (dfs) and overall survival (os) in locally advanced rectal cancer (larc).The nar score, which takes into account the pathological tumour and nodal stage as well as clinical tumour stage, is a validated surrogate endpoint used for early determination of treatment response whereby a low nar score ( 16) has been correlated with poorer outcomes.Ct images of 191 patients with larc were used in this study.Primary tumour (gtv) and mesorectum (ctv) were contoured separately and radiomics features were extracted from both segments.Two nar models (nar > 16 and nar 16 and nar 16 and nar < 8 models respectively, while the most significant clinical features are age, surgical margin and nar score across all the four survival models.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Maternal pro-inflammatory state during pregnancy and newborn leukocyte telomere length: A prospective investigation.

Introduction telomere biology plays a fundamental role in maintaining the integrity of the genome and cell, and shortened telomeres have been linked to several age-related diseases.The initial (newborn) telomere length (tl) represents a critically important feature of the telomere biology system.Exposure to a variety of adverse prenatal conditions such as maternal stress, suboptimal diet, obesity, and obstetric complications, is associated with shorter offspring tl at birth and in adult life.Many, if not all, of these exposures are believed to have an inflammatory component.In this context, stress-related immunological processes during pregnancy may constitute a potential additional biological pathway because they can affect telomere length and telomerase activity via transcriptions factors such as cyclic adenosine monophosphate-dependent transcription factor (atf7) and nuclear factor-kappa b (nf-κb).Thus, in the present study we examined the hypothesis that maternal pro-inflammatory state across pregnancy, operationalized as the balance between tumor necrosis factor (tnf)-α, a major pro-inflammatory cytokine, and interleukin-10 (il-10), the major anti-inflammatory cytokine, is associated with newborn leukocyte telomere length (ltl) at birth.Methods and materials participants were healthy women (n = 112) recruited in early pregnancy.Concentrations of tnf- α and il-10 were quantified in early, mid and late pregnancy from maternal blood samples.Telomere length was assessed in newborn blood samples soon after birth.Results after adjusting for maternal age, maternal pre-pregnancy bmi, birth weight percentile, and infant sex, a higher mean tnf-α/il-10 ratio across pregnancy was significantly associated with shorter newborn tl (β = -.205, p = .030).Newborn tl was, on average, 10% shorter in offspring of women in the upper compared to lower quartile of the tnf-α/il-10 ratio during pregnancy.Discussion these findings provide new evidence in humans for a potential "programming" mechanism linking maternal systemic pro-inflammatory processes during pregnancy with the initial (newborn) setting of her offspring's telomere system.

Journal: Brain, behavior, and immunity (2019)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Interaction of Serum Alkaline Phosphatase and Folic Acid Treatment on Chronic Kidney Disease Progression in Treated Hypertensive Adults.

The relation of alkaline phosphatase (alp) with chronic kidney disease (ckd) is still uncertain.We aimed to examine the prospective association between serum alp and ckd progression, and the modifying effect of serum alp on folic acid in preventing ckd progression in treated hypertensive patients.This is a post-hoc analysis of 12,734 hypertensive adults with relevant measurements and without liver disease at baseline from the renal sub-study of the china stroke primary prevention trial, where participants were randomly assigned to daily treatments of 10 mg enalapril and 0.8 mg folic acid, or 10 mg enalapril alone.The primary outcome was ckd progression, defined as a decrease in estimated glomerular filtration rate (e gfr) of ≥30% and to a level of <60 ml/min/1.73 m2if baseline e gfr was ≥60 ml/min/1.73 m2; or a decrease in e gfr of ≥50% if baseline e gfr was <60 ml/min/1.73 m2; or end-stage renal disease.Over a median of 4.4 years, in the enalapril only group, participants with baseline serum alp≥110iu/l (quartile 4) had a significantly higher risk of ckd progression (3.4%vs2.3%; adjusted or,1.61; 95%ci:1.11, 2.32), compared with those with alp<110iu/l.For those with enalapril and folic acid treatment, compared with the enalapril only treatment, the risk of ckd progression was reduced from 3.4 to 2.1% (adjusted or, 0.53; 95%ci:0.34, 0.83) among participants with baseline alp≥110iu/l, whereas there was no significant effect among those with alp<110iu/l.In hypertensive patients, higher serum alp was associated with increased risk of ckd progression, and this risk was reduced by 47% with folic acid treatment.

Journal: Frontiers in pharmacology (2021)
Publication types: Journal Article
Human Serum Low Molecular Mass Prostate-specific Antigen As Biomarker.

Prostate-specific antigen (psa) is a glycoprotein tumor marker known to exist as numerous glycospecies.Investigations on its glycobiochemical properties aimed at their use in the preparation of adjuncts in determining psa concentration for clinical purposes have accumulated a lot of data on its structural properties.In this study, we reconsidered unexplored ubiquitously present low molecular mass species of psa regarding to molecular mass, origin and pathophysiological source specificity in order to evaluate them as biomarkers.Methods data on low molecular mass psa-immunoreactive species from sera of subjects with prostate cancer (pca), benign prostatic hyperplasia (bph), breast cancer (bca), and urine of healthy males obtained by on-chip immunoaffinity chromatography combined with mass spectrometry were analyzed.Results the results obtained indicated psa species common to bca, pca, and bph at 12-13 k da, 17-19 k da and 21-24 k da.The striking difference in predominant frequencies made the profile characteristic in each examined pathophysiological condition.On the other hand, paired groups of prostatic and extraprostatic psa contained rare species with small differences among groups concerning individual species.Low molecular mass psa also included rare species unique for each group of samples.Conclusion the results obtained revealed that uniformity of low molecular mass psa-immunoreactive species in sera prevails over diversity related to cancer and non-cancer conditions, but at the same time some of them are molecules with biomarker potential for bph detection.

Journal: Journal of medical biochemistry (2017)
Publication types: Journal Article
Ecotoxicological Assessment of "Glitter" Leachates in Aquatic Ecosystems: An Integrated Approach.

The most worrisome fraction within plastic pollution is that of microplastics (mp).A category of mp almost completely ignored is that of glitter.The objective of this study is to test the toxicity of nine types of glitter leachate (3 soak times: 3, 90 and 180 days) on model organisms in freshwater (allivibrio fischeri,raphidocelis subcapitata,daphnia magna) and saltwater (allivibrio fischeri,phaeodactylum tricornutum,paracentrotus lividus).An integrated approach was applied to obtain the percentage of ecotoxicological risk.The results show that (i) photosynthesizing primary producers are the most sensitive trophic level; (ii) algae transitioned from growth inhibition to biostimulation; (iii)d.Magnashowed higher sensitivity after 48 h compared to 24 h; (iv)a.Fischeriresponded more strongly in saltwater than in freshwater.The integrated data show a greater risk associated with the marine environment, with the highest risk for glitters that are hexagonal and composed of poly-methyl-methacrylate.Our multivariate analysis shows that the toxicity of plastic leaching is a complex phenomenon that depends on the sensitivity of the species, in some cases on the soaking time and on the medium, and is not clearly linked to the polymer type, the contact area or the colors of the particles.

Journal: Toxics (2022)
Publication types: Journal Article
An ultra-sensitive rifampicin electrochemical sensor based on Fe3O4nanoparticles anchored Multiwalled Carbon nanotube modified glassy carbon electrode.

This study aimed to guide future sensor studies against other pharmaceutical drugs by synthesizing fe3o4nps@mwcnt metallic nanoparticles (nps).Side damage caused by excessive accumulation of tuberculosis drugs in the body can cause clots in the organs, and cause serious damage such as heart attack and respiratory failure, and threaten human life.Therefore, the development of sensors sensitive to various antibiotics in this study is important for human health.In this study, the sensitivity of fe3o4nps to tuberculosis drug (rifampicin) was evaluated by catalytic reaction using bare/gce, mwcnt/gce, and fe3o4nps@mwcnt/gce electrodes.First of all, fe3o4nps were successfully synthesized for the study and mwcnt/gce and fe3o4nps@mwcnt/gce electrodes were formed with the modification of the mwcnt support material.It was observed that the fe3o4nps@mwcnt/gce electrode gave the highest signal against the other electrodes.The morphological structure of fe3o4nps was determined by various characterization techniques such as transmission electron microscopy (tem), fourier transmission infrared spectroscopy (ftir), ultraviolet-visible (uv-vis), and x-ray differential (xrd) and the obtained nps were used for sensor studies, and it was observed that the current intensity increased as the scanning speed of each electrode increased in cv and dpv measurements.The average size of fe3o4nps was found to be 7.32 ± 3.2 nm.Anodic current peaks occurred in the linear range of 2-25 μm.According to the results obtained from the measurements, the limit of detection (lod) value was calculated as 0.64 μm limit of quantification (loq) 1.92 μm.

Journal: Chemosphere (2022)
Publication types: Journal Article
Effects of UV Absorber on Zirconia Fabricated with Digital Light Processing Additive Manufacturing.

This study evaluated the effect of uv absorbers on the dimensional accuracy of zirconia specimens fabricated by additive manufacturing using a digital light process.Zirconia suspension for additive manufacturing was prepared by setting the volume fractions (0, 0.005, 0.05, and 0.1%) of various uv absorbers.The effect of uv absorber content was evaluated through curing thickness, geometric overgrowth model design, linear deviation, and microstructure evaluation before and after sintering.Statistical analysis was performed by kruskal-wallis h and post-tested by the bonferroni correction method.There was no significant difference in the cure depth according to the presence or absence of the uv absorber, the difference in geometric overgrowth was from 2.1 to 12.5%, and the overgrowth significantly decreased as the amount of added uv absorber increased.This result may contribute to improved precision of 3d multilayer ceramic products.

Journal: Materials (Basel, Switzerland) (2022)
Publication types: Journal Article
High influenza vaccination coverage among healthcare workers in acute care hospitals in Finland, seasons 2017/18, 2018/19 and 2019/20.

Influenza vaccination is widely recommended for healthcare workers (hcws) in european countries, but the coverage is not always satisfactory.In finland, a new act was introduced in march 2017, according to which it is the employer's responsibility to appoint only vaccinated hcws for servicing vulnerable patients.aim we determined the influenza vaccination coverage among hcws in finnish acute care hospitals in three influenza seasons after introduction of the act.methods we analysed data collected by an internet-based survey sent annually to all finnish acute care hospitals and described the influenza vaccination coverage among hcws during seasons 2017/18, 2018/19 and 2019/20.We calculated mean coverage per healthcare district and season.results in season 2017/18, 38 of 39 hospitals, in 2018/19, 35 of 36 hospitals and in 2018/19 31 of 33 hospitals provided data.The mean influenza vaccination coverage was 83.7% (sd: 12.3) in season 2017/18, 90.8% (sd: 8.7) in 2018/19 and 87.6% (sd: 10.9) in season 2019/20.There was no significant increase or decrease in the mean coverage across the three seasons.The differences between districts were only significant in 2018/19 (p < 0.005).conclusions the coverage of influenza-vaccinated hcws in finnish hospitals was high in all three seasons and the current legal situation (semi-mandatory system) in finland seems to provide a good background for this.Data collection should be maintained and improved for further monitoring.

Journal: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin (2022)
Publication types: Journal Article
An update on liquid biopsy analysis for diagnostic and monitoring applications in non-small cell lung cancer.

Collection of tumor samples is not always feasible in non-small cell lung cancer (nsclc) patients, and circulating free dna (cf dna) extracted from blood represents a viable alternative.Different sensitive platforms have been developed for genetic cf dna testing, some of which are already in clinical use.However, several difficulties remain, particularly the lack of standardization of these methodologies.Areas covered: here, the authors present a review of the literature to update the applicability of cf dna for diagnosis and monitoring of nsclc patients.Expert commentary: detection of somatic alterations in cf dna is already in use in clinical practice and provides valuable information for patient management.Monitoring baseline alterations and emergence of resistance mutations is one of the most important clinical applications and can be used to non-invasively track disease evolution.Today, different technologies are available for cf dna analysis, including whole-genome or exome sequencing and targeted methods that focus on a selection of genes of interest in a specific disease.In the case of next generation sequencing (ngs) approaches, in depth coverage of candidate mutation loci can be achieved by selecting a limited number of targeted genes.

Journal: Expert review of molecular diagnostics (2018)
Publication types: Journal Article;Review
Is a female physical empowerment campaign effective in improving positive body image, motivation for physical activity, and physical activity behavior in young female adults? A two-study experimental test of "This Girl Can".

This girl can is a campaign designed to empower women to increase physical activity.The campaign uses images/videos of women of diverse body weights/shapes, ages and ethnicities being physically active, emphasizing body functionality.First, we examined the effects of multi-session (n = 3) exposures to this girl can on body functionality, body appreciation and self-compassion (study 1).Second, we explored if autonomous motivation for physical activity mediated effects of this girl can on physical activity (study 2).Women (study 1: n = 186, m (sd) age = 27.55 (14.01); study 2: n = 153, m (sd) age = 28.31 (11.70)) were randomized to this girl can, or control videos/images depicting idealized women of thin/athletic body types being physically active (study 1), or control videos highlighting physical activity benefits (study 2).Outcomes were measured at baseline, post-test and 1-week follow-up.Study 1 results showed significant group by time interactions for body functionality (decreasing in the control group), body appreciation and self-compassion (both increased only in the experimental conditions).In study 2, path analysis revealed no statistically significant mediation effect (ab = 13.18, 95 % ci [-107.92, 152.59]) of autonomous motivation.Future interventions designed to promote positive body image and self-compassion should incorporate media focusing on diverse women engaging in self-chosen physical activity.

Journal: Body image (2022)
Publication types: Journal Article;Randomized Controlled Trial
Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model.

Circular rna (circ rna) is a covalently closed single-stranded rna produced from pre-m rnasviaback-splicing reaction, an alternative form of splicing.Here, we show naphthyridine carbamate dimer (ncd) upregulating the production of a circ rna from a pre-m rna containing ncd-binding site uggaa/uggaa in cells, demonstrating the feasibility of small-molecule mediated circ rna production.

Journal: Chemical communications (Cambridge, England) (2022)
Publication types: Journal Article
Distribution Features and Potential Effects of Serotonin in the Cerebrum of SOD1 G93A Transgenic Mice.

Serotonin (5-ht) participates in the pathogenesis of amyotrophic lateral sclerosis (als), but its effects have not been completely clarified.Therefore, we observed the distribution features and potential effects of 5-ht in the cerebrum of g93a sod1 transgenic (tg) and wild-type (wt) mice by fluorescence immunohistochemistry, western blotting, elisa, as well as motor function measurements.Both 5-ht and tryptophan hydroxylase-2 (tph2) were mainly present in the limbic systems of the cerebrum, such as the glomerular layer of the olfactory bulb, nucleus accumbens, cingulate, fimbria of the hippocampus, mediodorsal thalamic nucleus, habenular nucleus, ventromedial hypothalamus nucleus, lateral hypothalamus area, dorsal raphe nucleus, and piriform cortex.Tph2 and 5-ht were expressed in cell bodies in the dorsal raphe nucleus and piriform cortex, while in other regions they were distributed as filaments and clump shapes in axons.The tph2 distribution in the cerebrum of tg was significantly lower than that in wt in preset, onset, and progression stages.Tph2 expression in the fimbria of the hippocampus, mediodorsal thalamic nucleus, habenular nucleus, ventromedial hypothalamus nucleus and lateral hypothalamus area was increased in the onset stage and decreased in the progression stage, gradually decreased in the cingulate with disease progression and significantly decreased in the glomerular layer of the olfactory bulb and nucleus accumbens in the onset stage in tg.The number of mammalian achaete-scute homolog-1 in the subventricular zone (svz) in tg was significantly lower than that in wt, which was correlated with the tph2 distribution.Double immunofluorescence staining showed that tph2, mammalian achaete-scute homolog-1 and 5-ht were mainly expressed in neurons but rarely expressed in microglia or astrocytes in the piriform cortex.The relative fluorescence density of tph2 in the cingulate region was negatively correlated with the disease severity.Our findings suggest that 5-ht plays a protective role in als, likely by regulating neural stem cells in the subventricular zone that might be involved in neuron development in the piriform cortex.

Journal: eNeuro (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't