syedzayyan/paper_mill_benchmark huggingface dataset:
Dermatofibrosarcoma protuberans: when the age makes the difference.

Dermatofibrosarcoma protuberans is a malignant tumor that affects exclusively the skin.It is a low-grade malignant tumor of subcutaneous tissues, characterized by a local recurrence but it seldom metastasizes.This study aimed to evaluate the impact of different clinical parameters on disease free survival and overall survival of dermatofibrosarcoma protuberans patients.Methods a retrospective study of data including seventeen cases of dermatofibrosarcoma protuberans (eleven male, six female) retrieved from the files of the dermatology clinics of la sapienza university, rome.We evaluated three clinical parameters (age, sex and anatomic site of the primary tumor) using the kaplan-meier product and the log-rank test.Results the results highlighted that patients with an age ≤49 years showed a median disease free survival of 36 months, while patients with an age ≥50 years of 4 months (p<0.0003).In addition, performing rank-correlation, only the variable age (p<0.0001) reached the statistical significance.Regarding overall survival, performing rank-correlation only the variable age reached the statistical significance (p=0.02).Conclusions our data suggests that age has a statistically significant role on disease free survival and overall survival of dermatofibrosarcoma protuberans patients.

Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia (2018)
Publication types: Journal Article
Measurement error is often neglected in medical literature: a systematic review.

S in medical research, covariates (e.g., exposure and confounder variables) are often measured with error.While it is well accepted that this introduces bias and imprecision in exposure-outcome relations, it is unclear to what extent such issues are currently considered in research practice.The objective was to study common practices regarding covariate measurement error via a systematic review of general medicine and epidemiology literature.Study design and setting original research published in 2016 in 12 high impact journals was full-text searched for phrases relating to measurement error.Reporting of measurement error and methods to investigate or correct for it were quantified and characterized.Results two hundred and forty-seven (44%) of the 565 original research publications reported on the presence of measurement error.83% of these 247 did so with respect to the exposure and/or confounder variables.Only 18 publications (7% of 247) used methods to investigate or correct for measurement error.Conclusions consequently, it is difficult for readers to judge the robustness of presented results to the existence of measurement error in the majority of publications in high impact journals.Our systematic review highlights the need for increased awareness about the possible impact of covariate measurement error.Additionally, guidance on the use of measurement error correction methods is necessary.

Journal: Journal of clinical epidemiology (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Systematic Review
Improving pathways to eliminate underrepresentation in the pediatric surgery workforce: A call to action.

Despite progress, diversity and minority representation within the pediatric surgery workforce still does not match the expansive backgrounds of the patients we treat.The problem stems from underrepresentation of minority populations at every step along the pediatric surgery training pathway.Strategies aimed at improving diversity and representation in medical school, general surgery residencies, and ultimately pediatric surgery fellowship are necessary to assemble a more diverse pool of pediatric surgeons.The aim of this paper is to review the current demographic make-up of medical and surgical specialties, highlight the value of diversity, and provide evidence-based strategies for increasing minority representation throughout the pediatric surgery pathway.Future patients will be better served with a more representative pediatric surgery workforce.

Journal: Journal of pediatric surgery (2022)
Publication types: Journal Article;Review
Leukocytapheresis in Chronic Myeloid Leukemia With Leukostasis.

Leukostasis in acute and chronic leukemias leads to increased cell burden and increased blood viscosity.Therapeutic leukocytapheresis is an automated procedure aimed at white blood cell depletion, and it thereby reduces the complications associated with increased blood viscosity, such as thrombotic events and mortality.In this report, we present the case of a 25-year-old patient with leukostasis and splenic laceration who was treated with therapeutic leukocytapheresis with symptomatic relief in leukostasis.

Journal: Cureus (2020)
Publication types: Case Reports;Journal Article
The Mediation Effect of Attitudes for the Association between Thoughts and the Use of Condoms in a Mobile-App Environment: From Thought to Intention.

The ubiquity of mobile devices and access to the internet has changed our daily life and, in some cases, promoted and facilitated social and sexual interrelationships.There are many applications of technology and campaigns promoting healthy behaviors and prevention of sexually transmitted infections.Can we develop a strategy for the same purpose using mobile devices, based on the theory of attitude change?We developed an app and tested it with 105 undergraduate students, where they had to actively think in favor of condom use with a high amount of elaboration, leading to attitudes and behavioral intention (bi) in concordance with contemporary theories about attitudes and behavioral change.Process macro models were used to analyze potential mediations.Results show a significant correlation between thoughts and attitudes, and attitudes partially mediated the association between thoughts and condom use.Individuals with positive thoughts tended to positively correlate their thoughts with their attitudes, and, consequently, these attitudes with their bi.In this study, we showed that (1) it was possible to develop and test an app based on the elaboration likelihood model (elm); (2) consistent with previous studies, attitudes partially mediated the association between thoughts and condom use (bi) in a mobile environment; and (3) applications of this strategy can be used to build new approaches for prevention in health care.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Criterion Validity and Test-Retest Reliability of a Modified Version of the International Physical Activity Questionnaire-Short Form (IPAQ-SF) in Kidney Transplant Recipients.

Introduction accelerometry, the clinically valued standard of physical activity monitoring, has limited acceptance in transplantation rehabilitation; therefore, the international physical activity questionnaire (ipaq) self-report instrument is widely used.However, while the ipaq's repeatability is good, its criterion validity is unsatisfactory.We hypothesized that adding a concise oral introduction would help overcome this shortfall.Materials and methods this is a secondary analysis of a rct in a sample of kidney transplant recipients that underwent observational follow-up.We assessed criterion validity of our modified version of the four-item ipaq-short form (m ipaq-sf)via pearson, and test-retest reliabilityviaintraclass correlation coefficients.The main difference in the new version is an oral pre-measurement introduction to the questionnaire's concepts.We compared our results with those of published studies.Results post-kidney-transplantation data of 92 patients were analyzed.Across the four ipaq-sf/m ipaq-sf items, values of correlations between m ipaq-sf responses and accelerometry records ranged from 0.07 (min in vigorous activity) to 0.35 (min in moderate activity) for criterion validity, and from 0.19 (days with moderate activity) to 0.58 (min in moderate activity) for test-retest reliability.Discussion regarding moderate-to-vigorous physical activity, m ipaq-sf self-reports' correlations to accelerometry records improved considerably on those of the ipaq-sf (r = 0.18 vs.R = 0.33), i.e., improved criterion validity.We therefore conclude that a pre-measurement oral explanation of key ipaq-sf/m ipaq concepts enhances criterion validity regarding self-reported moderate-to-vigorous physical activity.

Journal: Frontiers in rehabilitation sciences (2022)
Publication types: Journal Article
CD36 favours fat sensing and transport to govern lipid metabolism.

Cd36, located on the cell membrane, transports fatty acids in response to dietary fat.It is a critical fatty acid sensor and regulator of lipid metabolism.The interaction between cd36 and lipid dysmetabolism and obesity has been identified in various models and human studies.Nevertheless, the mechanisms by which cd36 regulates lipid metabolism and the role of cd36 in metabolic diseases remain obscure.Here, we summarize the latest research on the role of membrane cd36 in fat metabolism, with emphasis on cd36-mediated fat sensing and transport.This review also critically discusses the factors affecting the regulation of cd36-mediated fat dysfunction.Finally, we review previous clinical evidence of cd36 in metabolic diseases and consider the path forward.

Journal: Progress in lipid research (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't
Construction of a nursing care protocol for children in post-hematopoietic stem cell transplantation.

To construct a nursing care protocol for children in post-hematopoietic stem cell transplantation.Method methodological research carried out from january to september 2019, in three steps: (a) integrative review (nursing care was identified); (b) theoretical structuring and organization of healthcare based on the theory of basic human needs and on the international classification for nursing practice (supplementing the review data); and (c) development of a protocol in the three previously mentioned stages.Analysis of the understanding of the protocol's items/care was performed by three specialist nurses.Results the care protocol consists of 40 nursing problems and is organized in accordance with the psychobiological, psychosocial, and psycho-spiritual needs of children undergoing transplantation, integrating practical and guidance care.Conclusion the care protocol is an important technology for nursing care to transplanted children, aimed to prevent and manage transplantation complications.

Journal: Revista gaucha de enfermagem (2022)
Publication types: Journal Article
A cross-sectional study on the anatomic feasibility of iliac side branch grafts in a real-world setting.

The aim of this cross-sectional, single-center study was to analyze the feasibility of different commercially available iliac branch devices in europe in a cohort of patients with aorto-iliac aneurysms.Methods all patients with aorto-iliac or iliac aneurysms that required iliac aneurysm repair, between 2017 and 2021, were included.Morphologic data was analyzed using computed tomography angiograms.The main outcome was the feasibility of each endoprosthesis (cook zbis, gore iliac branch endoprosthesis [ibe], and jotec e-iliac) according to the manufacturer's instructions for use.Secondary outcomes were feasibility in all three devices, in any device, and with adjunctive procedures (liberal criteria).Additionally, a comparative analysis of all three grafts was performed to analyze differences in feasibility.Results overall, 119 iliac aneurysms in 101 patients were included.The mean age was 71 ± 11 years, and 91.6% were male.Feasibility was 52.9% for cook zbis, 33.6% for gore ibe, and 26.9% for the jotec e-iliac device.A total of 65.5% of patients were feasible with at least one device, whereas only 10.1% complied with all three devices.The main reasons for lack of feasibility were a short common iliac artery length (cook zbis), a narrow common iliac artery diameter (gore ibe), and a >50° angulation between the external and internal iliac arteries (jotec e-iliac).There was a significant difference between the feasibility of the three devices (p < .001).Cook zbis was the graft with the higher feasibility, with 3.3 and 4.4 higher odds when compared with gore ibe and jotec e-iliac devices, respectively.There was no significant difference between the gore ibe and the jotec e-iliac.By using liberal criteria, the overall feasibility increased to 95.8%.Conclusions we found that only 65.5% of patients were feasible with one of the available devices according to the manufacturer's instructions for use.The cook zbis was the device with the overall highest feasibility.Extending the use of these devices with adjunctive measures and a more liberal approach increased feasibility to 95.8%.

Journal: Journal of vascular surgery (2022)
Publication types: Journal Article
Chemogenetic Silencing of Differentiating Cortical Neurons Impairs Dendritic and Axonal Growth.

Electrical activity is considered a key driver for the neurochemical and morphological maturation of neurons and the formation of neuronal networks.Designer receptors exclusively activated by designer drugs (dreadds) are tools for controlling neuronal activity at the single cell level by triggering specific g protein signaling.Our objective was to investigate if prolonged silencing of differentiating cortical neurons can influence dendritic and axonal maturation.The dreadd h m4di couples to gi/osignaling and evokes hyperpolarizationvia girk channels.Hm4di was biolistically transfected into neurons in organotypic slice cultures of rat visual cortex, and activated by clozapine-n-oxide (cno) dissolved in h2o; controls expressed h m4di, but were mock-stimulated with h2o.Neurons were analyzed after treatment for two postnatal time periods, div 5-10 and 10-20.We found that cno treatment delays the maturation of apical dendrites of l2/3 pyramidal cells.Further, the number of collaterals arising from the main axon was significantly lower, as was the number of bouton terminaux along pyramidal cell and basket cell axons.The dendritic maturation of l5/6 pyramidal cells and of multipolar interneurons (basket cells and bitufted cells) was not altered by cno treatment.Returning cno-treated cultures to cno-free medium for 7 days was sufficient to recover dendritic and axonal complexity.Our findings add to the view that activity is a key driver in particular of postnatal l2/3 pyramidal cell maturation.Our results further suggest that inhibitory g protein signaling may represent a factor balancing the strong driving force of neurotrophic factors, electrical activity and calcium signaling.

Journal: Frontiers in cellular neuroscience (2022)
Publication types: Journal Article
Selective estrogen receptor modulators (SERMS): keys to understanding their function.

Selective estrogen receptor modulators (serms) are an increasingly important therapeutic modality that are used by clinicians on a daily basis.Unfortunately, clinicians have a limited understanding regarding the underlying mechanism(s) of how serms function and their increasingly useful role in the treatment of estrogen-responsive target tissues such as the breast, bone, vagina, uterine endometrium, and brain.This review will provide a basic understanding of our current knowledge of serm pharmacodynamics and will highlight the clinical applications of food and drug administration-approved serms in the treatment of vasomotor symptoms, osteoporosis, genitourinary syndrome of menopause, infertility, and breast cancer and its prevention.Serms under development and natural phytoestrogens will also be reviewed.

Journal: Menopause (New York, N.Y.) (2020)
Publication types: Journal Article;Review
Geographic differentiation in male calling song ofIsophyamodestior(Orthoptera, Tettigoniidae, Phaneropterinae).

We studied the songs and morphology of the stridulatory file of isophyamodestioracross its complete geographic range, in order to test our hypothesis that the male calling song of the species shows strong differentiation between the northern (pannonian) and southern (balkan) parts of its distribution range, reflecting its disjunct distribution.Our analyses confirm this hypothesis, separating analyzed specimens of i.modestiorinto two main groups - one present in the central part of the balkan peninsula (representing isophyamodestiorsensu stricto), with the second group occurring in the pannonian basin, dinarides, slovenia and ne italy.The most reliable difference between the groups is the duration of the main syllable, the number of stridulatory teeth and number of pulses in the main syllable, where all values are higher in specimens from the balkan peninsula.Additional analyses showed that within the second group, there are differences in analyzed characters between specimens from the pannonian basin and specimens from the dinaric area, the latter ones having intermediate song characteristics, closer to the group from the balkan peninsula.Our study shows that detailed bioacoustic analyses can help to unravel patterns of intraspecific differentiation and thus provide a useful tool for taxonomic studies.

Journal: ZooKeys (2022)
Publication types: Journal Article
Tgm1-like transglutaminases in tilapia (Oreochromis mossambicus).

Among the adaptations of aquatic species during evolution of terrestrial tetrapods was the development of an epidermis preventing desiccation.In present day mammals, keratinocytes of the epidermis, using a membrane-bound transglutaminase (tgm1), accomplish this function by synthesizing a scaffold of cross-linked protein to which a lipid envelope is attached.This study characterizes the abilities of two homologous transglutaminase isozymes in the teleost fish tilapia to form cross-linked protein structures and their expression in certain tissues.Results indicate they are capable of membrane localization and of generating cellular structures resistant to detergent solubilization.They are both expressed in epithelial cells of the lip, buccal cavity and tips of gill filaments.Adaptation of transglutaminase use in evolution of terrestrial keratinocytes evidently involved refinements in tissue expression, access to suitable substrate proteins and activation of cross-linking during terminal differentiation.

Journal: PloS one (2017)
Publication types: Journal Article
Functionally specific optogenetic modulation in primate visual cortex.

In primates, visual perception is mediated by brain circuits composed of submillimeter nodes linked together in specific networks that process different types of information, such as eye specificity and contour orientation.We hypothesized that optogenetic stimulation targeted to cortical nodes could selectively activate such cortical networks.We used viral transfection methods to confer light sensitivity to neurons in monkey primary visual cortex.Using intrinsic signal optical imaging and single-unit electrophysiology to assess effects of targeted optogenetic stimulation, we found that (i) optogenetic stimulation of single ocular dominance columns (eye-specific nodes) revealed preferential activation of nearby same-eye columns but not opposite-eye columns, and (ii) optogenetic stimulation of single orientation domains increased visual response of matching orientation domains and relatively suppressed nonmatching orientation selectivity.These findings demonstrate that optical stimulation of single nodes leads to modulation of functionally specific cortical networks related to underlying neural architecture.

Journal: Proceedings of the National Academy of Sciences of the United States of America (2018)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
The Effects of Interdisciplinary Bedside Rounds on Patient Centeredness, Quality of Care, and Team Collaboration: A Systematic Review.

Research indicates that having multiple healthcare professions and disciplines simultaneously at the patient's bedside improves interprofessional communication and collaboration, coordination of care, and patient-centered shared decision-making.So far, no review has been conducted, which included qualitative studies, explores the feasibility of the method, and looks at differences in definitions.Objectives the aim of the study was to explore available evidence on the effects of interdisciplinary bedside rounds (ibrs) on patient centeredness, quality of care and team collaboration; the feasibility of ibrs; and the differences in definitions.Data sources pub med, web of science, and cochrane databases were systematically searched.The reference lists of included articles and gray literature were also screened.Articles in english, dutch, and french were included.There were no exclusion criteria for publication age or study design.Study appraisal and synthesis methods the included (n = 33) articles were critically reviewed and assessed with the downs and black checklist.The selection and summarizing of the articles were performed in a 3-step procedure, in which each step was performed by 2 researchers separately with researcher triangulation afterward.Conclusions and implications of key findings interdisciplinary bedside round has potentially a positive influence on patient centeredness, quality of care, and team collaboration, but because of a substantial variability in definitions, design, outcomes, reporting, and a low quality of evidence, definitive results stay uncertain.Perceived barriers to use ibr are time constraints, lack of shared goals, varied responsibilities of different providers, hierarchy, and coordination challenges.Future research should primarily focus on conceptualizing ibrs, in specific the involvement of patients, before more empiric, multicentered, and longitudinal research is conducted.

Journal: Journal of patient safety (2022)
Publication types: Journal Article;Systematic Review
A novel preoperative analysis method of upper blepharoplasty: Movable pulley concept.

Up to date, many surgical techniques have been introduced for upper eyelid rejuvenation.Despite those technical advances, little attention has been put on objective preoperative analysis methods.Objectives the current study introduces our simplified, versatile, and predictable upper eyelid analysis method for upper blepharoplasty patients.Methods a total of 1509 surgeries were performed from march 2017 to may 2021 using our preoperative analysis method.Results as a result of the operation based on this new analysis method, it was possible to individualize the plan according to the patient's needs and obtain satisfactory outcomes.Conclusions using our simplified, versatile, and predictable upper eyelid analysis method, we could counsel the surgical result with high predictability.In addition, it is a highly recommended method for beginners as it is easy to understand the mechanism of double eyelid surgery.

Journal: Journal of cosmetic dermatology (2022)
Publication types: Journal Article