syedzayyan/paper_mill_benchmark huggingface dataset:
Predictive Value of Perioperative Cytokine Levels on the Risk for In-Stent Restenosis in Acute Myocardial Infarction Patients

To investigate the value of perioperative cytokine levels in predicting the risk for in‐stent restenosis in patients with acute myocardial infarction.452 patients with acute myocardial infarction admitted to our hospital between june 2018 and june 2020 were prospectively selected as subjects.All patients underwent percutaneous coronary intervention.The baseline data of the patients were collected.Venous blood was taken before, 24 hours, and 3 days after the operation to detect the levels of related cytokines.Follow‐up was performed for 1 year.The patients were assigned to restenosis and nonrestenosis groups according to the presence and absence of restenosis.Multivariate logistic analysis was used to explore the influencing factors of the risk for in‐stent restenosis in patients with acute myocardial infarction.By july 1, 2021, 449 cases had been followed up.Of them, 44 cases suffered from in‐stent restenosis and 405 cases did not affect in‐stent restenosis.The incidence of in‐stent restenosis was 9.80%.Before, 24 hours, and 3 days after the operation, the lipoprotein‐associated phospholipase a2 (lp‐pla2) level was significantly higher in the restenosis group than that in the nonrestenosis group.At 3 days after the operation, the interleukin 6 (il‐6) level was significantly higher in the restenosis group than that in the nonrestenosis group ( p &lt; 0.05).Multivariate logistic analysis displayed that lp‐pla2 level preoperatively (or = 1.048, 95% ci 1.029–1.068), lp‐pla2 level 24 hours postoperatively (or = 1.013, 95% ci 1.007–1.019), lp‐pla2 level 3 days postoperatively (or = 1.032, 95% ci 1.015–1.048), and il‐6 level 3 days postoperatively (or = 1.020, 95% ci 1.000–1.040) were risk factors for in‐stent restenosis (all p &lt; 0.05).Il‐6 and lp‐pla2 levels can predict the risk for in‐stent restenosis in patients with acute myocardial infarction in the perioperative period.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Predictive Value of HPV E6/E7 mRNA Detection on the Outcome of Cervical LSIL

To assess the predictive worth of hpv e6/e7 m rna detection in the outcome of the cervical low-grade squamous intraepithelial lesion (lsil).From september 2017 to early september 2019, patients screened for high-risk hpv positive or abnormal cervical liquid-based cytology were retrospectively analyzed and diagnosed with lsil by cervical biopsy were recruited.The independent influencing factors of the regression of lsil lesions after follow-up were analyzed, and the outcome of lsil was calculated.The results of the initial colposcopy in this study were cin i, cin ii/p16-negative, cin ii/p16-positive, and cin iii.At the time of re-examination, lsil patients had three outcomes: regression, persistence, and progression.In the two follow-ups, 330 patients were finally included, including 276 cin i patients (group a) and 54 cin ii/p16-negative patients (group b).The positive rates of hpv e6/e7 m rna in each group were 66.67% and 70.37% for a and b, respectively.The total positive rate of e6/e7 m rna was 67.27%, and there was no significant difference between the two groups ( p &gt; 0.05 ).After 1 year follow-up, whether hpv e6/e7 m rna regressed or was negative was associated with the outcome of lsil-related lesions ( p &lt; 0.05 ).The regression or negative rate of hpv e6/e7 m rna was 1.57 times higher than the progression rate of hpv e6/e7 m rna-positive diagnosis of lsil lesions.Univariate logistic regression analysis showed that age at first sexual intercourse, hpv e6/e7 m rna results, and lesion type were statistically significant ( p &lt; 0.05 ).Whether hpv e6/e7 m rna was negative (or = 2.420, p = 0.001 ) and age at first sexual intercourse ≥20 years (or = 0.420, p = 0.002 ) were independent influencing factors associated with lsil regression.Multivariate logistic analysis showed that age of first sexual intercourse ≥20 years (or = 0.420, p = 0.002 ) and hpv e6/e7 m rna-negative (or = 2.420, p = 0.001 ) were independent factors associated with lsil.Hpv e6/e7 m rna detection can be used for predicting the outcome of lsil and has a good application value.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Prediction of Incidence Trend of Influenza-Like Illness in Wuhan Based on ARIMA Model

The autoregressive integrated moving average (arima) model has been widely used to predict the trend of infectious diseases.This paper is aimed at analyzing the application of the arima model in the prediction of the incidence trend of influenza-like illness (ili) in wuhan and providing a scientific basis for the prediction and prevention of influenza.Methods.The weekly ili data of two influenza surveillance sentinel hospitals in wuhan city published on the website of the national influenza center of china were collected, and the arima model was used to model the data from 2014 to 2020, to predict and verify the ili data in 2021.Results.The optimal model for the incidence trend of ili in wuhan was arima 1 , 1 , 1 , the residuals were in line with the white noise sequence ( 0.018 &lt; ljung ‐ box q &lt; 30.695 , p &gt; 0.05 ), and the relative error between the predicted value and the actual value was small, which all proved the model was practical.Conclusion.Arima 1 , 1 , 1 can effectively simulate the short-term incidence trend of ili in wuhan.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Pravastatin Reduces Matrix Metalloproteinases Expression and Promotes Cholesterol Efflux in Osteoarthritis Chondrocytes

Chondrocyte metabolic disorder plays an important role in the development of osteoarthritis (oa).The use of statins in the treatment of oa has also been widely studied, but the mechanism is still confusing.The present study aims to investigate the effects of statin on osteoarthritis chondrocytes and its underlying mechanism.Major findings.An untargeted metabolomics study revealed that the treatment of statins significantly changed the metabolites of articular cartilage tissues collected from female osteoarthritis patients, and might be involved in the glycerophospholipid metabolism pathway.In vitro study showed that 5–50 μmol/l of pravastatin exerts no cytotoxicity on human chondrocytes.Besides, 50 μmol/l of pravastatin caused a significant decrease in the expression of matrix metalloproteinase (mmp)-1 and mpp-13, and intracellular cholesterol in interleukin-1β (il-1β)-induced human chondrocytes.Furthermore, at both m rna and protein levels, the expression of the proteins related to the cholesterol efflux pathway (liver x receptor and cholesterol efflux regulatory protein) were significantly up-regulated by 50 μmol/l of pravastatin in il-1β-induced human chondrocytes.Conclusion.Pravastatin can reduce the expression of mmps in il-1β-induced human chondrocytes and protect the chondrocyte matrix.The mechanism may be related to promoting the expression of proteins related to the cholesterol efflux pathway and reducing the level of cellular cholesterol.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
PCBP2 Reduced Oxidative Stress-Induced Apoptosis in Glioma through cGAS/STING Pathway by METTL3-Mediated m6A Modification

The most prevalent primary malignant tumor of cns is glioma, which has a dismal prognosis.The theory of oxidative stress is one of the important theories in the study of its occurrence and development mechanism.In this study, the impacts of pcbp2 on glioma sufferers and the possible mechanisms were examined.Methods.Patients with glioma were obtained from may 2017 to july 2018.Quantitative pcr, microarray analysis, western blot analysis, and immunofluorescence were used in this experiment.Results.Pcbp2 m rna expression level and protein expression in patients with glioma were upregulated compared with paracancerous tissue.Os and dfs of pcbp2 low expression in patients with glioma were higher than those of pcbp2 high expression.Pcbp2 promoted the progression and metastasis of glioma.Pcbp2 reduced oxidative stress-induced apoptosis of glioma.Pcbp2 suppressed the c gas/sting pathway of glioma.Pcbp2 protein interlinked with c gas and c gas was one target for pcbp2.Mettl3-mediated m6a modification increases pcbp2 stability.Conclusion.Along the c gas-sting signal pathway, pcbp2 decreased the apoptosis that oxidative stress-induced glioma caused, which might be a potential target to suppress oxidative stress-induced apoptosis of glioma.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Observation on the Clinical Effect of Acupuncture and Moxibustion Combined with Repeated Transcranial Magnetic Stimulation on Facial Paralysis

In view of the difficulty in the treatment of facial paralysis and the poor effect of traditional methods, this paper proposes a strategy based on acupuncture and repeated transcranial magnetic stimulation.The three groups of patients were tested for efficacy using the h-b scale and the symptom characteristics and physical signs measurement scale.Acupuncture combined with repetitive transcranial magnetic stimulation can improve the clinical efficacy of facial paralysis.And it is significantly better than traditional paralysis and repetitive translational magnetic stimulation in the degree of healing.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Clinical Study;
Observation of the Curative Effect of Acupuncture for Tonifying Kidney and Removing Blood Stasis Combined with Radiofrequency Surgery in Patients with NSCLC and the Diagnostic Efficacy of Combined Detection of NTx, BGP, and CYFRA21-1 in the Occurrence of

The curative effect observation of acupuncture for tonifying kidney and removing blood stasis combined with radiofrequency surgery in patients with non‐small‐cell lung carcinoma (nsclc) and the diagnostic efficacy of combined detection of ntx, bgp, and cyfra21‐1 for bone metastases are investigated.122 nsclc patients admitted to our hospital from january 2019 to december 2021 are selected for the examination, and the two sets of patients are randomly divided into the study set and the control set using the random number table method, with 61 cases in each set.Patients in the control set are given ct‐guided percutaneous radiofrequency ablation therapy, and patients in the study set are given a combination of acupuncture therapy for tonifying the kidney and removing blood stasis on the basis of the therapy of the control set.The experimental results show that for nsclc patients, the application of kidney‐tonifying and stasis‐removing acupuncture therapy combined with radiofrequency surgery can notoriously enhance the clinical therapy effect and enhance the quality of life of patients, and the detection of ntx, bgp, and cyfra21‐1 indicators can effectively predict the prognosis.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Clinical Study;
Visual Dissemination of Intangible Cultural Heritage Information Based on 3D Scanning and Virtual Reality Technology

In order to meet the needs of modern people for the acquisition of intangible cultural heritage information, the authors propose a research method that combines 3d scanning and virtual reality technology.Taking the production process of xiuyu as an example, using unity3d virtual reality technology combined with a digital platform, 3d modeling of xiuyu is carried out, so that people can view the intangible cultural heritage information intuitively.The experimental results show that after using this method, more than 60% of more than 1000 people surveyed in the questionnaire want to experience intangible cultural heritage.In a survey of visualization platforms conducted at the same time, 90% of users are willing to combine jade carving technology with 3d scanning virtual reality technology.Conclusion.3d scanning and virtual reality technology can further promote the process of inheritance and dissemination of intangible cultural heritage, accelerate the cultivation of intangible cultural heritage talents through the visualization platform, and promote the sustainable development of intangible cultural heritage, in order to better pass down the life memory and cultural genes of our ancient nation.

Journal: Scanning (2022)
Publication types: Research Article;
To Analyze the Influencing Factors of Senile Coronary Heart Disease Patients Complicated with Frailty Syndrome

To analyze the influencing factors of senile coronary heart disease patients complicated with frailty syndrome.A total of 80 elderly patients with coronary heart disease admitted to our hospital from march 2020 to march 2021 were selected as the research subjects.The fried frailty symptom scale was used to evaluate whether the 80 patients were complicated with frailty syndrome.According to the evaluation results, the patients were divided into a nonfrailty syndrome group (52 cases in total) and frailty syndrome group (28 cases in total).Clinical data of two groups of patients were collected, and multivariate logistic regression was used to analyze the influencing factors of senile coronary heart disease patients complicated with frailty syndrome.Among 80 patients, the incidence of frailty syndrome was 35.00% (28/80), including 18 cases in early frailty and 10 cases in frailty stage.Univariate analysis showed that age, body mass (bmi), diabetes mellitus, congestive heart failure, chronic renal insufficiency, chronic obstructive pulmonary disease (copd), tumor, high uric acid hematic disease, arrhythmia, interleukin-6 (il-6), c-reactive protein (crp), fibrinogen (fib), brain natriuretic peptide (bnp), uric acid (ua), serum creatinine (scr), serum protein (alb), white blood cell count (wbc), and neutrophil count were the possible risk factors for senile coronary heart disease complicated with frailty syndrome ( p &lt; 0.05).Multivariate logistic regression analysis showed that combined copd, combined tumor, il-6, bnp, ua, scr, alb, and neutrophil count were independent risk factors for senile chd complicated with frailty syndrome ( p &lt; 0.05).Combined with copd, combined with tumor, il-6, bnp, ua, scr, alb, and neutron cell count are the influencing factors for senile coronary heart disease patients complicated with frailty syndrome.These factors can be used as the basis for the diagnosis of frailty syndrome and guide the clinical development of targeted diagnosis and treatment plan.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Surgical Strategy and Prognosis of Pancreatic Neuroendocrine Tumors Based on Smart Medical Imaging

It is imperative to seize the “golden rescue time” and implement new concepts and new skills in modern trauma rescue.Combining with the development background of smart medical image analysis, this topic focuses on surgical strategies and prognostic measures and studies a serious and difficult disease frequently occurring in middle‐aged and elderly people: pancreatic neuroendocrine tumors.This article uses the comparative test method and sample collection method to collect the medical records of patients with neuroendocrine tumors diagnosed by pathology from july 2010 to january 2018 in the first affiliated hospital of x city and analyze the samples with gender and age.At the same time, routine tumor marker examination and the location of nen in the digestive system were performed.The distribution analysis of eus characteristics of neuroendocrine tumor mucosa in each site was performed after operation, and the analysis of survival‐related factors was performed during postoperative follow‐up.The experimental data showed that among the tumor causes, who tumor grade ( p &lt; 0.05) and whether the surgical method was r0 resection ( p &lt; 0.05) were associated with prognosis.However, factors such as gender, age, and functional status were associated with prognosis.It has successfully completed the subject of surgical strategy and prognosis of pancreatic neuroendocrine tumors based on smart medical image analysis.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Nitric Oxide Inhalation Therapy Attenuates Postoperative Hypoxemia in Obese Patients with Acute Type A Aortic Dissection

To investigate the differences between inhaled nitric oxide (i no) treatment and conventional therapy in the treatment of postoperative hypoxemia in obese patients with acute type a aortic dissection (ataad).Methods.Ataad patients diagnosed and treated with emergency surgery in our hospital from june 2017 to december 2019 were retrospectively analyzed.Patients with postoperative hypoxemia were divided into the i no group and control group.Propensity score matching was used to analyze clinical characteristics and results of the two groups.Results.A total of 218 ataad patients with bmi ≥ 25 were treated with surgery.Among them, 115 patients developed refractory hypoxemia (64 in the control group and 51 in the i no group).Patients in the i no group had significantly shorter invasive mechanical ventilation time, intensive care unit (icu) stay, and hospital stay.After 6 h of i no treatment, the pa o2/fi o2 ratio in the i no group increased significantly, and this ratio was higher than that in the control group at 6, 12, 24, 48, and 72 h after treatment.Conclusion.Low-dose i no could improve oxygenation and shorten mechanical ventilation and icu stay in patients with hypoxemia after ataad surgery, but without significant side effects or increase in postoperative mortality or morbidity.These findings provide a basis for a randomized multicenter controlled trial to assess the efficacy of i no in the treatment of hypoxemia after ataad surgery.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Pathologic Complete Response and Its Impact on Breast Cancer Recurrence and Patient’s Survival after Neoadjuvant Therapy: A Comprehensive Meta-Analysis

Earlier research has illustrated prognostic significance of pathologic complete response (p cr) in neoadjuvant therapy (nat) for breast cancer, whereas correlation between treatment after achieving p cr and survival improvement remains underexplored.We attempted to measure the relation between p cr achieved after nat and breast cancer recurrence or patient’s survival.Methods.We searched pub med, embase, web of science, and the cochrane library databases to find relevant articles from their inception to november 2020.According to eligibility criteria, studies were selected and basic data were extracted.The primary endpoint was the correlation between p cr achieved after nat and event-free survival (efs) or overall survival (os).The results were obtained by directly extracting specific information from the literature or estimating individual data by survival curves on digitize it software, presented with hr and 95% ci.All data were processed on stata 14.0 software.Results.Among 4338 articles, there were 25 eligible articles involving 8767 patients.The efs of patients achieved p cr after nat improved obviously ( hr = 0.27 ; 95% ci, 0.24-0.31), especially in triple negative ( hr = 0.17 ; 95% ci, 0.12-0.24) and her2 positive ( hr = 0.24 ; 95% ci, 0.20-0.30) breast cancer patients.As such, p cr after nat was implicated in significantly increased os ( hr = 0.32 ; 95% ci, 0.27–0.37).Conclusion.Achieving p cr after nat was notably related to the improvement of efs and os, especially for patients with triple-negative and her2-positive breast cancer.P cr can be a surrogate indicator for outcome of breast cancer patients after nat, as well as a predictor of treatment efficacy after nat.Besides, well-designed studies are still warranted for confirmation.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Meta-Analysis;
Optimization of AES-128 Encryption Algorithm for Security Layer in ZigBee Networking of Internet of Things

With the rapid development of network and communication technology, the interaction of various information data is more and more frequent, and people pay more and more attention to information security.The information encryption algorithm is a research hotspot in the field of information security.The advanced encryption standard (aes) algorithm has been widely used in the field of information security with its high security and encryption efficiency.This paper mainly introduces the optimization of the aes-128 encryption algorithm of the security layer in zig bee networking of the internet of things.By analyzing the principles of zig bee networking and the aes encryption algorithm, the changes are optimized.In this paper, the new s-box cryptographic properties are used after analysis and calculation.The affine transformation period, the number of iteration cycles, and the algebraic expression of the s-box are improved.Its cryptographic properties are better than the s-box of the original algorithm, and the security of the algorithm is improved.In the theory of column hybrid algorithm, the computational complexity is reduced by changing the fixed polynomial, and the efficiency of the column hybrid algorithm is improved.In this paper, the performance of the improved aes algorithm is tested.The results show that, in the power consumption curve experiment, the recovery success rate of the original algorithm is about 42%, and the recovery success rate of the improved algorithm is nearly 60%.The improved algorithm is faster than the original algorithm in achieving a recovery success rate of 100%.Experimental results show that the design can accurately complete the encryption and decryption of the aes algorithm, and the performance is better than the original algorithm, which proves the overall superiority of the algorithm.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
miR-30a-5p Regulates Viability, Migration, and Invasion of Lung Adenocarcinoma Cells via Targeting ECT2

The abnormal expression of epithelial cell transforming sequence 2 (ect2) is often considered the driving factor for the growth and invasion of tumors.This study was performed to investigate the regulatory effect of mi r-30a-5p and ect2 on lung adenocarcinoma (luad), which provides a basis for the effective clinical treatment of luad.Methods.The mature mi rnas, expression data of m rnas, and clinical data of luad were downloaded from the cancer genome atlas (tcga).The expression levels of ect2 m rna and mi r-30a-5p in cancer cell lines were detected by q rt-pcr.Western blot was performed to test the expression of ect2 protein.The targeting relationship between mi r-30a-5p and ect2 was verified by dual-luciferase assay.The cck-8 method and transwell assay were conducted to test the viability, migratory, and invasive abilities of cells.Results.Ect2 expression was upregulated in luad and was significantly correlated with the luad clinical stage and pathologic t stage, and the expression of its upstream regulatory gene mi r-30a-5p was downregulated.Mi r-30a-5p targeted ect2 in luad.Downregulation of ect2 could inhibit the viability, migration, and invasion of luad cells, which could be reversed by simultaneously suppressing the expression of mi r-30a-5p.Conclusion.Our results suggested that mi r-30a-5p repressed the malignant progression of luad via downregulating ect2.Mi r-30a-5p and ect2 may be effective targets for luad patients.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;