syedzayyan/paper_mill_benchmark huggingface dataset:
Dynamic Changes and Influencing Factors for the Quality of Life in Nursing Care after Lung Cancer Resection

To investigate the dynamic changes and influencing factors for the quality of life in nursing care in patients with lung cancer after resection.Totally, 136 patients undergoing lung cancer resection in our hospital from january 2019 to january 2022 were prospectively enrolled as subjects.The quality of life was measured before and 1 and 2 weeks and 1, 3, 6, and 12 months after the operation to analyze the dynamic changes in the quality of life in nursing care.Clinical data of patients were collected at the time of discharge.The patients were divided into high‐quality and low‐quality groups according to the median level of quality of life in nursing care at the final follow‐up.The logistic regression equation was applied to analyze the influencing factors for the quality of life in nursing care after lung cancer resection.Of 136 patients receiving lung cancer resection, 32 were lost to follow‐up until the final follow‐up, so 104 patients were finally included.According to the median level of quality of life in nursing care at the final follow‐up, the patients were divided into high‐quality and low‐quality groups ( n = 52 per group).The quality of life in nursing care first decreased, then increased, and then stabilized after lung cancer resection.The comparison of clinical data between the two groups exhibited that albumin level was higher in the high‐quality group than that in the control group.The age, proportion of living alone, s‐ai score, and fo p‐q‐sf score were lower in the high‐quality group than those in the low‐quality group ( p &lt; 0.05).Univariate logistic regression analysis demonstrated that high albumin ( or = 0.884) was a protective factor for the quality of life in nursing care after lung cancer resection ( p &lt; 0.05).Living alone ( or = 1.333), high s‐ai score ( or = 1.211), high fo p‐q‐sf score ( or = 1.221), and advanced age ( or = 1.209) were the risk factors for the quality of life in nursing care after lung cancer resection ( p &lt; 0.05).Multivariate logistic regression analysis demonstrated that high albumin ( or = 0.861) was a protective factor for the quality of life in nursing care after lung cancer resection ( p &lt; 0.05).Living alone ( or = 1.144), high s‐ai score ( or = 1.170), high fo p‐q‐sf score ( or = 1.161), and advanced age ( or = 1.181) were the risk factors for the quality of life after lung cancer resection ( p &lt; 0.05).The quality of life in nursing care first decreased, then increased, and then stabilized after lung cancer resection.Albumin, age, living alone, and s‐ai and fo p‐q‐sf scores were the influencing factors for the quality of life in nursing care after lung cancer resection.In the nursing care process after lung cancer resection, we should focus on elderly patients living alone who are affected by anxiety and fear of recurrence to improve the quality of life of these patients.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Detection of WBC, RBC, and Platelets in Blood Samples Using Deep Learning

A blood count is one of the most important diagnostic tools in medicine and one of the most common procedures.It can reveal important changes in the body and is commonly used as the first stage in the process of evaluating patients’ health.Even though this is a common practice, delivering examinations in laboratories can be difficult due to the availability of expensive technology that requires frequent maintenance.This study is developing an alternative deep learning computational model capable of automatically detecting cells in images of blood samples.Using object detection libraries, it was possible to train a model that was focused on this task and capable of detecting cells in images with adequate accuracy.When the identification of cells in images of blood samples was taken into account in the best results obtained, it was possible to count white cells with an accuracy of one hundred percent, red cells with an accuracy of 89%, and platelets with an accuracy of 96%, which generated subsidies to develop the primary components of a blood count.The components that were supposed to classify the various types of white cells were not carried out due to the limits of the dataset provided.On the other hand, the study can be broadened to include further works that deal with this issue because it produced satisfactory results.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Design of the Physical Fitness Evaluation Information Management System of Sports Athletes Based on Artificial Intelligence

With the rapid development of science and technology in recent years, more and more researchers began to explore the basic disciplines of sports, namely, biomechanics and physiology, and further update and improve the traditional sports training theory.However, the developed countries, i.e., europe and the united states, have dedicatedly worked on the effective role of physical training particularly in middle-class farmers in sports powers.They have realized that the continuous improvement of the physical training evaluation system is directly related to the reforming in the evaluation and monitoring methods of physical training.At the same time, there is a demand for athletes’ physical fitness evaluation, which requires a large amount of data support during the evaluation.These data collection and analysis are difficult and consume a lot of manpower.Therefore, this paper uses artificial intelligence technology to design the sports athletes’ physical fitness evaluation information management system to improve the comprehensiveness of system data collection and the accuracy of data analysis.Through the physical attenuation calculation and physical analysis of the system developed in this paper, data accuracy is high.The coach can make a training plan according to the physical consumption of athletes in sports training or competition, which can greatly improve the ability of athletes.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
DDTC Suppresses Ovarian Cancer Development via the PI3K/AKT/mTOR Signaling Pathway

In prior research, 6,12-diphenyl-3,9-diazatetraasterane-1, 5, 7, 11-tetracarboxylate (ddtc) has been shown to be an effective inhibitor of the growth of the skov3 and a2780 ovarian cancer (oc) cell lines.Flow cytometry analyses indicated that ddtc was able to suppress p-cna expression at the protein level within oc cells, while rna-seq indicated that ddtc treatment was associated with marked changes in gene expression profiles within a2780 cells.Molecular docking analyses suggested that ddtc has the potential to readily dock with key signaling proteins including pi3k, akt, and m tor.In line with these findings, ddtc treatment inhibited the growth of xenograft tumors in a mouse model system.Such treatment was also associated with reduced p-pi3k/pi3k, p-akt/akt, p-m tor/m tor, and cyclin d1 (ccnd1) expressions and with the increased expression of pten in vitro and in vivo.Together, these results suggest that ddtc is capable of readily inhibiting oc development at least in part via targeting and modulating signaling via the pi3k/akt/m tor axis.

Journal: Disease Markers (2022)
Publication types: Research Article;
Correlation between Intestinal Microflora in Irritable Bowel Syndrome and Severity

Irritable bowel syndrome (ibs) is a common chronic functional gastrointestinal disease accompanied by changes in intestinal microecology.This study investigated the relationship between gut microbiota and disease severity in patients with irritable bowel syndrome (ibs).Methods.An observational study was performed on 60 ibs patients (study group) and 20 healthy controls admitted to our hospital from january 2013 to december 2014.Fecal samples were taken after admission to measure intestinal flora including bifidobacterium, lactobacillus, enterobacter, and enterococcus, and patient blood was collected to determine serum d-lactate and diamine oxidase (dao) levels.The gut microbiota and serum markers of the two groups were analyzed.The correlation of gut microbiota index levels and serum markers with disease severity, as well as the correlation between gut microbiota index levels and serum markers, were analyzed.Results.The levels of intestinal lactobacillus and bifidobacterium were lower, while the levels of enterococcus and enterobacter and serum d-lactate were higher in the study group than those in the control group.The levels of intestinal lactobacillus and bifidobacterium were lower, while the levels of enterococcus and enterobacter, serum d-lactate, and dao were higher in patients with moderate ibs than those in patients with mild ibs.The levels of intestinal lactobacillus and bifidobacterium were lower in patients with severe ibs than those with moderate ibs, while the levels of enterococcus and enterobacter, serum d-lactate, and dao were higher in patients with severe ibs.There was a significant negative correlation between the levels of lactobacillus and bifidobacterium and disease severity and a significant positive correlation between the levels of enterococcus and enterobacter, d-lactate, and dao and disease severity.There was a significant negative correlation between the levels of lactobacillus and bifidobacterium and serum d-lactate and dao, while there was a significant positive correlation between the levels of enterococcus and enterobacter and serum d-lactate and dao ( p &lt; 0.05 ).Conclusion.Intestinal flora, d-lactate, and dao were abnormal in ibs patients, and intestinal flora was closely correlated with disease severity, d-lactate, and dao levels.

Journal: Disease Markers (2022)
Publication types: Clinical Study;
Correlation and Prognostic Action of SAA, Hcy, and BNP Levels with the Condition of Patients with Spontaneous Intracerebral Hemorrhage

To explore the correlation of serum amyloid a (saa), homocysteine (hcy), and plasma b-type brain natriuretic peptide (bnp) levels in patients with spontaneous intracerebral hemorrhage (sich) and their predictive value for the status and prognosis of sich patients.Methods.82 sich patients admitted to our hospital from march 2017 to march 2020 were selected.According to the glasgow coma scale (gcs) score, the patients were divided into gcs &gt; 8 group (n = 44) and the gcs ≤ 8 group (n = 38).Based on the bleeding volume, the patients were divided into the massive bleeding group (&gt;30 ml) (n = 21), the moderate bleeding group (10∼30 ml) (n = 28), and the small bleeding group (&lt;10 ml) (n = 33).Based on the prognostic status of patients after 28 days of admission, they were divided into the survival group (n = 64) and the death group (n = 18).Serum saa, hcy, and plasma bnp levels of patients in different groups were compared, and the correlation between serum saa, hcy and plasma bnp levels with gcs score, cerebral hemorrhage, and the prognostic value of patients was analyzed.Results.Serum saa, hcy, and plasma bnp levels in patients with gcs ≤ 8 groups were higher than those in gcs &gt; 8 groups ( p &lt; 0.05 ).Serum saa, hcy, and plasma bnp levels of patients in the massive bleeding group were higher than those in the moderate and small bleeding groups.Besides, the level of serum saa, hcy, and plasma bnp in the moderate bleeding group was higher than that in the small bleeding group ( p &lt; 0.05 ).Serum saa, hcy and plasma bnp levels of patients were negatively correlated with gcs scores but positively correlated with bleeding volume ( p &lt; 0.05 ).The levels of serum saa, hcy and plasma bnp in dead patients were higher than those in the survival patients ( p &lt; 0.05 ).The combined prediction of serum saa, hcy, and plasma bnp for the prognosis of sich patients was 0.910 (95% ci: 0.984∼0.837), which was higher than the serum saa, hcy, and plasma bnp alone predicted auc 0.679 (95% ci: 0.564∼0.795), 0.720 (95% ci: 0.603∼0.836), and 0.726 (95% ci: 0.616∼0.849).Conclusion.The levels of serum saa, hcy, and plasma bnp have a correlation with the severity and prognosis of patients with sich, which is a feasible index for judging the prognosis of sich.The levels of serum saa, hcy, and plasma bnp are conducive to timely judgment of the progression and prognosis of sich patients.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
The Sp1/FOXC1/HOTTIP/LATS2/YAP/β-catenin cascade promotes malignant and metastatic progression of osteosarcoma

The prognosis for osteosarcoma (os) is dismal due to the aggressive tumor growth and high incidence of metastasis.The long noncoding rna human homeobox a transcript at the distal tip (hottip) and the transcription factor forkhead box c1 (foxc1) present oncogenic activities in os.Here, we aimed at gaining insights into the underlying mechanisms and their crosstalk.The expression of foxc1 and hottip in os tissues or cell lines was examined by real‐time pcr (rt‐pcr) and western blot.The in vitro effects of foxc1 or hottip on cell viability, proliferation, migration, invasion, and expression of target genes were examined using mtt, colony‐forming assay, wound‐healing, transwell invasion, and western blot, respectively; the in vivo effects were examined using xenograft and experimental metastasis models.Molecular control of hottip on large tumor suppressor 2 (lats2) or transactivation of foxc1 or sp1 on hottip was assessed by combining rna immunoprecipitation, q rt‐pcr, western blot, ch ip, and luciferase assay.Both foxc1 and hottip were potently up‐regulated in os tissues and cell lines.Foxc1 and hottip essentially maintained viability, proliferation, migration, and invasion of os cells in vitro and contributed to xenograft growth or lung metastasis in vivo .Mechanistically, hottip recruited enhancer of zeste homolog 2 (ezh2) and lysine‐specific demethylase 1 (lsd1) to silence lats2 and thus activated yap/β‐catenin signaling.Upstream, sp1 activated foxc1 and they both directly transactivated hottip.In summary, we showed that the sp1/foxc1/hottip/lats2/yap/β‐catenin cascade presented oncogenic activities in os cells.Targeting foxc1 or hottip may therefore prove beneficial for os treatment.

Journal: Molecular Oncology (2020)
Publication types: Research Article;
Long Non-Coding RNA PVT1/miR-150/ HIG2 Axis Regulates the Proliferation, Invasion and the Balance of Iron Metabolism of Hepatocellular Carcinoma

To investigate the biological roles and underlying molecular mechanisms of long non-coding rna (lnc rna) pvt1 in hepatocellular carcinoma (hcc).Methods: q rt-pcr was performed to measure the expression of mi rna and m rna.Western blot was performed to measure the protein expression.Cck-8 assay was performed to determine cell proliferation.Flow cytometry was performed to detect cell apoptosis.Wounding-healing assay and transwell assay was performed to detect cell migration and invasion.Dual luciferase reporter assay was performed to verify the target relationship.Quantichrom iron assay was performed to check uptake level of cellular iron.Results: pvt1 expression was up-regulated in hcc tissues and cell lines.Function studies revealed that pvt1 knockdown significantly suppressed cell proliferation, migration and invasion, and induced cell apoptosis in vitro.Furthermore, pvt1 could directly bind to micro rna (mi r)-150 and down-regulate mi r-150 expression.Hypoxia-inducible protein 2 (hig2) was found to be one target gene of mi r-150, and pvt1 knockdown could inhibit the expression of hig2 through up-regulating mi r-150 expression.In addition, the expression of mi r-150 was down-regulated, while the expression of hig2 was up-regulated in hcc tissues and cell lines.Moreover, inhibition of mi r-150 could partly reverse the biological effects of pvt1 knockdown on proliferation, motility, apoptosis and iron metabolism in vitro, which might be associated with dysregulation of hig2.In vivo results showed that pvt1 knockdown suppressed tumorigenesis and iron metabolism disorder by regulating the expression of mi r-150 and hig2.Conclusion: taken together, the present study demonstrates that pvt1/mi r-150/hig2 axis may lead to a better understanding of hcc pathogenesis and provide potential therapeutic targets for hcc.

Journal: Cellular Physiology and Biochemistry (2018)
Publication types: Research Article;
Correlation Analysis of Ultrasound Elastography Score with Invasive Breast Cancer and Biological Prognostic Factors

Invasive breast cancer (ibc) is a kind of malignant tumor in which cancer cells have broken through the basement membrane of breast ducts or lobular acini and invaded the stroma.Although ultrasound elastography score (ues) has shown unique advantages in the diagnosis of ibc, its value in the prognosis is not clear.Here, we explored the correlation of ues with ibc and biological prognostic factors.The datum of 86 patients with suspected ibc from january 2018 to december 2021 was collected.Ue was applied in the examination of all patients.The lesion tissue of the malignant group was punctured to detect and analyze the expression of biological prognostic factors, including estrogen receptor (e receptor), progesterone receptor (p receptor), and human epidermal growth factor 2 (her factor 2) and ki67.The differences in ues under different biological prognostic factors were compared.The receiver operating characteristic (roc) curve was applied to analyze the diagnostic value of ues of ibc and the expression of biological prognostic factors.Based on the pathological diagnosis results, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of ues in the diagnosis of ibc were analyzed.The correlation of ues with ibc and biological prognostic factors was analyzed by multiple linear regression and spearman method.Roc analysis showed that the area under the curve of ues for diagnosing ibc and evaluating the expression of p receptor, her factor 2, and ki67 were 0.877, 0.704, 0.763, and 0.820, respectively ( p <0.05).The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of ues when diagnosing ibc were 92.42%, 90.00%, 91.86%, 96.83%, and 78.26%, respectively.The ues of e receptor expression (positive and negative group) showed no obvious variance ( p &gt; 0.05).The ues of p receptors (positive and negative), her factor 2 (positive and negative), and ki67 (high and low expression) showed obvious differences ( p &lt; 0.05).Multiple linear regression and spearman indicated ues was significantly correlated with the expression of p receptor, her factor 2, and ki67 ( p <0.05).Ues has a certain diagnostic value for ibc and is significantly correlated to the expression of p receptor, her factor 2, and ki67, which is helpful for evaluating the prognosis of patients with ibc.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Comparative Study on the Clinical Effects of Different Surgical Methods in the Treatment of Gastrointestinal Stromal Tumors

The objective is to compare the clinical efficacy of laparoscopic resection (lap), endoscopic full-thickness resection (efr), and endoscopic submucosal dissection (esd) in the treatment of gastrointestinal stromal tumors.Methods.The clinical data of 105 patients who were treated in our hospital and diagnosed with gist by pathology after surgery from march 2019 to march 2021 were collected.Patients were divided into the lap group, efr group, and esd group according to different surgical methods.The clinical data, surgical conditions, complications, and postoperative conditions of the patients were recorded retrospectively.Patients were followed up closely after surgery.Results.The operation time of the efr group and esd group was shorter than that of the lap group, and the operation time of the efr group was shorter than that of the esd group ( p &lt; 0.05 ).The amount of intraoperative blood loss in the efr group and esd group was lower than that in the lap group ( p &lt; 0.05 ).There was no significant difference in the complete resection rate among the three groups ( p &gt; 0.05 ).There was no significant difference in the total incidence of complications among the three groups ( p &gt; 0.05 ).The postoperative abdominal pain time, postoperative hospital stay, and total hospitalization costs of the efr group and esd group were lower than those of the lap group ( p &lt; 0.05 ).No recurrence or metastasis cases were found in the three groups during the follow-up period, and there were no gist-related deaths in the three groups.Conclusion.Lap, efr, and esd have good curative effect, good safety, and good prognosis in the treatment of gist.But compared with lap, efr and esd have the advantages of less trauma, faster recovery, shorter hospitalization time, and lower hospitalization cost.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Commodity Information Collection and System Construction of e-Commerce Platform Based on Network Data

In order to quickly and accurately collect the massive commodities and corresponding transaction data of large-scale e-commerce platforms, and improve the ability of data analysis and mining, this paper proposes a platform commodity information collection system based on splash technology.The system prerenders the javascript code in the product page, combined with the scrapy crawler framework, to realize a system that quickly and effectively collects product data from different platforms, and uses “mobile phone” as the retrieval keyword to verify the designed system, respectively.The experimental results show that the system can effectively collect up to 60,000 comments and 6,000 system requests.Conclusion.The platform commodity information collection system based on splash technology has certain application value and promotion for the commodity data collection of different platforms of e-commerce.

Journal: Wireless Communications and Mobile Computing (2022)
Publication types: Research Article;