syedzayyan/paper_mill_benchmark huggingface dataset:
Effects of Pollution on Freshwater Organisms.

The scientific literature review in this paper includes research papers published in 2017 on issues related to pollutants from human activity and its effects on organisms of freshwater reported from the different parts of the world.The fist part of the literature review highlights on two broad sections that are focused on research conducted at the field level as well as surveys based on field experiments.A number of sections categorized in order to reflect the different class of pollutants follows the first part of literature review.Sections in this part of review includes non-point source pollution, stormwater, wastewater, nutrients, sediment cap materials and suspended clays, botanical extracts, surfactants, metals, persistent organic pollutants, pharmaceuticals, endocrine disruptors, pesticides, petroleum hydrocarbons and polycyclic aromatic hydrocarbons, nanomaterials and ionic liquids.The final part of the literature review highlights the published research on recent innovations of recent in addressing problem of pollution in the freshwater and its management.

Journal: Water environment research : a research publication of the Water Environment Federation (2018)
Publication types: Journal Article;Review
Telehealth Readiness Assessment of Perinatal Nurses.

To assess telehealth readiness among perinatal nurses in new jersey.Design cohort survey study.Setting/local problem new jersey was one of the hardest hit areas in the early months of the covid-19 pandemic.Telehealth represented an opportunity to provide continuity of perinatal care at a time when health care was significantly disrupted.Participants perinatal nurses in new jersey.Intervention/measurements the intervention was a five-part, 90-question online survey provided via e-mail invitation to new jersey state nursing association members.Data were collected from june 25 to july 9, 2020.Descriptive statistics, frequency analyses, a mann-whitney test on nonparametric measures of groups by age, and a one-tailed t test were completed.Results of the telehealth readiness assessment tool were calculated.Open-text responses were organized and used to illustrate the findings.Results fifty-two perinatal nurses responded to the survey.Twenty-two (42%) completed all 90 questions.Partial answers were accepted.Synchronous live telehealth expanded 66% in the wake of covid-19.Results showed that 37% (n = 15) of participants used telehealth at work, and 27% (n = 11) used it in getting care for themselves or a family member (m = 2.0, sd = 0.86; one-tailed t test, p = .25).In comparing nervousness in using technology with age, scores for those younger than 45 years (mdn = 3) and those older than 45 years (mdn = 2) showed no statistically significant difference, u(n<45years= 15, n≥45 years= 17) = 11, z = -0.02, p < .83.Overall, 46% (n = 26) indicated that telehealth could be extremely helpful or very helpful in reducing health care disparities and improving quality.Overall, telehealth readiness was ranked almost ready.Conclusion a telehealth readiness assessment may identify barriers and opportunities that can predict success and failure.Nurses generally accept technology and believe that telehealth could be useful in reducing poor maternal health outcomes and health care disparities.

Journal: Nursing for women's health (2022)
Publication types: Journal Article
The genomic and proteomic landscape in oral lichen planus versus oral squamous cell carcinoma: a scoping review.

Oral lichen planus (olp), a world health organization (who)-classified oral potentially malignant condition, confers a 1% risk of transformation to oral squamous cell carcinoma (oscc).There does not appear to be a consensus understanding of the underlying molecular events.This scoping review aimed to identify critical molecular pathways and highlight gaps in existing knowledge on malignant transformation in olp.Methods following preferred reporting items for systematic reviews and meta-analysis protocols (prisma-p) guidelines, a comprehensive literature search and methodical screening identified 61 relevant studies detailing molecular differences between olp and oscc.Results molecular changes shared between olp and oscc included those affecting cellular proliferation (altered p53 expression, hypermethylation of p16/cdkn2a, myc gains, increased ki-67), apoptosis (increased bcl-2 and survivin expression), extracellular matrix (ecm) remodeling (increased matrix metalloproteinase [mmp] expression), and transcriptional control (altered bmi1 and micro rna [mi rna] expression).In addition, some molecular alterations accumulated incrementally from control to olp to oscc or were present in higher-risk erosive variants of olp or transformed olp.Few studies included rigorous diagnostic inclusion criteria or unbiased discovery methods.Conclusions results of this review support the potentially malignant nature of olp and imply that molecular events associated with malignant transformation may be heterogeneous.In addition, findings in this review highlight the need for additional studies using rigorous diagnostic inclusion criteria and unbiased discovery methods to further understand this process.

Journal: International journal of dermatology (2022)
Publication types: Journal Article;Review
Perspectives on long pentraxin 3 and rheumatoid arthritis: several potential breakthrough points relying on study foundation of the past.

Rheumatoid arthritis (ra) is a systemic chronic autoimmune inflammatory disease which is mainly characterized by synovitis and results in a severe burden for both the individual and society.To date, the underlying mechanisms of ra are still poorly understood.Pentraxin 3 (ptx3) is a typical long pentraxin protein which has been highly conserved during evolution.Meanwhile, functions as well as properties of ptx3 have been extensively studied.Several studies identified that ptx3 plays a predominate role in infection, inflammation, immunity and tumor.Interestingly, ptx3 has also been verified to be closely associated with development of ra.We therefore accomplished an elaboration of the relationships between ptx3 and ra.Herein, we mainly focus on the associated cell types and cognate cytokines involved in ra, in combination with ptx3.This review infers the insight into the interaction of ptx3 in ra and aims to provide novel clues for potential therapeutic target of ra in clinic.

Journal: International journal of medical sciences (2021)
Publication types: Journal Article;Review
Steroid therapy and antiviral treatment in SARS-CoV-2 pneumonia: clinical contexts and indications.

Critically ill patients with covid-19 face a higher risk of disease progression and complications.The current standard of care includes supportive care measures and fluid management.The recovery trial observed a reduction in all-cause, 28-day mortality (p<0.001) when patients with covid-19 requiring oxygen therapy received 6 mg of dexamethasone per day for 10 days.In contrast, in patients not requiring oxygen, no benefit was observed: 28-day mortality rates for the dexamethasone and routine care groups were 17.8% and 14%, respectively.To corroborate these results, the world health organization (who) performed a meta-analysis.The study showed that the use of systemic corticosteroids compared with routine care placebo was associated with a decrease in all-cause, 28-day mortality.With respect to the effectiveness of remdesivir, the actt-1 trial found that the drug conferred a benefit on time to clinical improvement.The subgroup analysis in the clinical trial also showed a benefit per mortality in patients requiring supplemental oxygen, albeit not those in need of mechanical ventilation.

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia (2022)
Publication types: Journal Article;Meta-Analysis;Review
Development of Cancer Among Patients With Pediatric-Onset Inflammatory Bowel Disease: A Meta-analysis of Population-Based Studies.

Importance because the incidence of pediatric-onset inflammatory bowel disease (ibd) is increasing, knowledge of the long-term risk of cancer in this patient population is required.Objective to evaluate the relative rate of cancer among patients with pediatric-onset ibd.Data sources a comprehensive systematic search was performed of medline and embase from the date of database inception to october 31, 2021.Study selection all unselected, population-based cohort studies of pediatric-onset ibd assessing the risk of cancer were included.Tertiary center referrals and insurance database studies were excluded.All articles were assessed by 2 independent reviewers.Data extraction and synthesis the study followed the preferred reporting items for systematic reviews and meta-analyses reporting guideline for data extraction and used the newcastle-ottawa scale for assessment of the risk of bias and the quality of included articles.Main outcomes and measures a random-effects model meta-analysis was conducted of included studies using the inverse-variance method to assess the relative rate of cancer overall and by ibd subtype (crohn disease or ulcerative colitis), sex, and thiopurine exposure among patients with pediatric-onset ibd.Pooled relative rates (p rrs) along with 95% cis were calculated for combined studies.Results of 4628 articles screened, 5 population-based studies from north america and europe were eligible for inclusion.These studies comprised 19 812 individuals with pediatric-onset ibd followed up for 283 540 person-years in which 715 cases of cancer were identified.Meta-analysis of p rr estimates showed a 2.4-fold increased rate of cancer among patients with pediatric-onset ibd (p rr, 2.46; 95% ci, 2.06-2.93), seen among patients with crohn disease (p rr, 2.03; 95% ci, 1.67-2.46) and those with ulcerative colitis (p rr, 2.61; 95% ci, 2.00-3.40).This increased rate is primarily due to an increased rate of liver (p rr, 55.45; 95% ci, 19.59-156.99), colorectal (p rr, 20.29; 95% ci, 15.90-25.90), and small bowel (p rr, 16.20; 95% ci, 3.52-74.66) cancers.The incidence rate of cancer among patients with pediatric-onset ibd was reported by 4 studies and ranged from 1.0 to 3.3 cases per 1000 person-years.Conclusions and relevance this meta-analysis of unselected, population-based studies showed a greater than 2-fold increased rate of cancer among patients with pediatric-onset ibd compared with the general pediatric populations, primarily owing to an increased rate of gastrointestinal cancers.

Journal: JAMA network open (2022)
Publication types: Journal Article;Meta-Analysis;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Sustainability analysis of bioethanol production from grain and tuber starchy feedstocks.

A comparative sustainability study of bioethanol production from selected starchy feedstocks that are abundantly available was carried out in this work.This is to ensure the safe, reliable, and efficient production and consumption of fuel-grade bioethanol.The analysis utilised the established economic minimum bioethanol plant capacity of 158,000 m3/annum.The processing flowsheet model utilised was the same for each feedstock.The sustainability study's economic, environmental, and energy perspectives were investigated.The economic and environmental indices were assessed using superpro designer and open lca sustainability software, respectively.Exergy and lost work were subsequently estimated manually with microsoft excel.The economic analyses showed that the plants using cassava and sweet potato initially had the highest return on investment (roi) of 64.41 and 41.96% respectively at a minimum of 80% plants' capacity utilisation.The break-even point occurs at a bioethanol price of $3.27 per gallon, beyond which positive net present values were obtained for the four processes.The least profitable plant was based on sorghum recording an roi value of 34.11%.The environmental assessment on the four selected feedstocks showed that the processes based on cassava, corn, sweet potato, and sorghum recorded encouraging global warming potential (gwp) of 0.2452, 0.2067, 2.5261, and 0.2099 kg co2equivalent respectively.Cassava and corn emerged as the two most economically viable feedstocks when economic parameters were adjusted to include pollutants emission/discharge costs but with a slight decrease in profitability indices.The lost work analyses showed that distillation columns were the least energy-efficient units in the four bioethanol production routes assessed, recording loss work of about 61, 68, 34, and 49 mw for cassava, sweet potato, corn, and sorghum processing plants respectively.However, the net energy balance (neb) and energy renewability results of the four production routes showed that the processes utilising the four selected starchy biomass feedstocks are more sustainable compared to fossil fuels.

Journal: Scientific reports (2022)
Publication types: Journal Article
Applying infectious disease forecasting to public health: a path forward using influenza forecasting examples.

Infectious disease forecasting aims to predict characteristics of both seasonal epidemics and future pandemics.Accurate and timely infectious disease forecasts could aid public health responses by informing key preparation and mitigation efforts.Main body for forecasts to be fully integrated into public health decision-making, federal, state, and local officials must understand how forecasts were made, how to interpret forecasts, and how well the forecasts have performed in the past.Since the 2013-14 influenza season, the influenza division at the centers for disease control and prevention (cdc) has hosted collaborative challenges to forecast the timing, intensity, and short-term trajectory of influenza-like illness in the united states.Additional efforts to advance forecasting science have included influenza initiatives focused on state-level and hospitalization forecasts, as well as other infectious diseases.Using cdc influenza forecasting challenges as an example, this paper provides an overview of infectious disease forecasting; applications of forecasting to public health; and current work to develop best practices for forecast methodology, applications, and communication.Conclusions these efforts, along with other infectious disease forecasting initiatives, can foster the continued advancement of forecasting science.

Journal: BMC public health (2019)
Publication types: Journal Article
Nurses' views and applications on palliative care.

This study was carried out descriptively to determine the view and applications about pallative care of nurses working in a university hospital.Design and methods the data were collected with the questionnaire form: "individual information form" and "views and appllications on palliative care," created by the researchers in line with the literature.Findings a total of 96.6% of the nurses evaluated the scope of palliative care as pain relief, and the most common difficulties in care were identified as bad news (88.1%).In all, 22.0% of the nurses talked to the patient and their family about death.Practice implications it is thought that the majority of nurses are not trained in palliative care and their opinions about palliative care are affected by this situation.

Journal: Perspectives in psychiatric care (2021)
Publication types: Journal Article
Differential navigational strategies during spatial learning in a new modified version of the Oasis maze.

During spatial navigation, some typical parameters of learning have been observed, such as latency or path length.However, these parameters are sensitive to patterns of navigation and orientation that are not easily measurable.In the present study, we used a modified version of the oasis maze and evaluated different parameters of learning, navigation, and orientation in different animal groups.Through a pca (principal component analysis) we found different factors such as learning, navigation, speediness, anxiety, orientation, path variability, and turning behavior.Each factor gathers different groups of behavioral variables.Anova analysis of those factors demonstrates that some of them are more strongly modulated by trial progression, while others by animal group differences, indicating that each group of variables is better reflecting one of these dimensions.To understand the nature of these navigation differences, we studied orientation strategies between animal conditions and across trials.We found that the main navigational strategy used by the animals consist of locating the target and directing their behaviors towards this area.When testing how this strategy changed after cognitive impairment or enhancement, we found that aβos treated animals (amyloid β oligomers, alzheimer animal model) have strong orientation difficulties at locating the target at longer distances.While animals with learning enhancement (exercised rat) do not show changes in orientation behaviors.These analyses highlight that experimental manipulations affect learning, but also induced changes in the navigational strategies.We concluded that both dimensions can explain the differences observed in typical learning variables, such as latency or path length, motivating the development of new tools that asses this two-dimension as a separate but, interacting phenomenon.

Journal: Behavioural brain research (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Autophagy Is a Potential Target for Enhancing the Anti-Angiogenic Effect of Mebendazole in Endothelial Cells.

Mebendazole (mbz), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has recently been noted as a repositioning candidate for angiogenesis inhibition and cancer therapy.However, the definite anti-angiogenic mechanism of mbz remains unclear.In this study, we explored the inhibitory mechanism of mbz in endothelial cells (ecs) and developed a novel strategy to improve its anti-angiogenic therapy.Treatment of ecs with mbz led to inhibition of ec proliferation in a dose-dependent manner in several culture conditions in the presence of vascular endothelial growth factor (vegf), basic fibroblast growth factor (b fgf) or fbs, without selectivity of growth factors, although mbz is known to inhibit vegf receptor 2 kinase.Furthermore, mbz inhibited ec migration and tube formation induced by either vegf or b fgf.However, unexpectedly, treatment of mbz did not affect fak and erk1/2 phosphorylation induced by these factors.Treatment with mbz induced shrinking of ecs and caused g2-m arrest and apoptosis with an increased sub-g1 fraction.In addition, increased levels of nuclear fragmentation, p53 expression, and active form of caspase 3 were observed.The marked induction of autophagy by mbz was also noted.Interestingly, inhibition of autophagy through knocking down of beclin1 or atg5/7, or treatment with autophagy inhibitors such as 3-methyladenine and chloroquine resulted in marked enhancement of anti-proliferative and pro-apoptotic effects of mbz in ecs.Consequently, we suggest that mbz induces autophagy in ecs and that protective autophagy can be a novel target for enhancing the anti-angiogenic efficacy of mbz in cancer treatment.

Journal: Biomolecules & therapeutics (2019)
Publication types: Journal Article
Safety and efficacy of a feed additive consisting of carmine for cats and dogs (Mars Petcare GMbH).

Following a request from the european commission, efsa was asked to deliver a scientific opinion on the re-evaluation of the safety and efficacy of carmine (sensory additive, functional group: colourants - substances that add or restore colour in feeds) for cats and dogs.The additive consists of aluminium lakes of carminic acid (carmines), which are complexes of aluminium and carminic acid.Carminic acid, produced from the female insect dactylopius coccus costa, is the colouring principle and is present in the final additive at 50%.The additive does not pose a risk concerning genotoxicity and is considered safe for dogs and cats at 264 and 220 mg carmine/kg feed, respectively (which correspond to 132 and 110 mg carminic acid/kg feed, respectively).Due to the nature of the additive, the feedap panel concluded that allergic reactions may occur in the target species following the ingestion of feeds containing the additive.The feedap panel concluded that the exposure of users by inhalation is very likely, and that carmine is a respiratory and skin sensitiser; however, due to the lack of data, a conclusion cannot be reached on the potential skin and eye irritation of the additive.The additive is considered to be efficacious in feeds for dogs and cats under the proposed conditions of use.

Journal: EFSA journal. European Food Safety Authority (2022)
Publication types: Journal Article
Cefiderocol Treatment for Severe Infections due to Difficult-to-Treat-Resistant Non-Fermentative Gram-Negative Bacilli in ICU Patients: A Case Series and Narrative Literature Review.

Cefiderocol (fdc) is a siderophore cephalosporin now recognized as a new weapon in the treatment of difficult-to-treat-resistant (dtr) gram-negative pathogens, including carbapenemase-producing enterobacterales and non-fermentative gram-negative bacilli (gnb).This article reports our experience with an fdc-based regimen in the treatment of 16 extremely severe patients (invasive mechanical ventilation, 15/16; extracorporeal membrane oxygenation, 9/16; and renal replacement therapy, 8/16) infected with dtr gnb.Our case series provides detailed insight into the pharmacokinetic profile and the microbiological data in real-life conditions.In the narrative review, we discuss the interest of fdc in the treatment of non-fermentative gnb in critically ill patients.We reviewed the microbiological spectrum, resistance mechanisms, pharmacokinetics/pharmacodynamics, efficacy and safety profiles, and real-world evidence for fdc.On the basis of our experience and the available literature, we discuss the optimal fdc-based regimen, fdc dosage, and duration of therapy in critically ill patients with dtr non-fermentative gnb infections.

Journal: Antibiotics (Basel, Switzerland) (2023)
Publication types: Journal Article;Review
Incidence and risk factors for the development of cerebral metastasis in cervical cancer patients.

Cerebral metastasis (cm) in cervical cancer (cc) cases, although rare, results in high lethality rates.The present study aimed to assess cm incidence in a brazilian reference cc center and evaluate the risk factors for cm development.Retrospective observational study of patients diagnosed with cc between 2010 and 2017.Methods cumulative cm incidence and incidence density were evaluated.Characteristics associated to cm development risks were identified using crude (c or) or adjusted (a or) odds ratios.Results a total of 3,397 patients were included in this study.Patient age ranged from 18 to 101 years, with a mean age of 48.8±14.0.After a mean follow-up time of 3.2±2.1 years, 51 cm cases were identified, resulting in a cumulative incidence of 1.5% (95% confidence intervals [ci]=1.12-1.97) and an incidence density at the end of the 6th year of 27.4 per 1,000 women/year.Advanced clinical stage (a or=3.15; 95% ci=1.16-8.58; p=0.025), the presence of previous lung metastasis (a or=4.04; 95% ci=1.82-8.94; p=0.001) and the adenocarcinoma (a or=2.90; 95% ci=1.46-5.76; p=0.002), adenosquamous carcinoma (a or=7.33; 95% ci=2.87-18.73; p<0.001), undifferentiated carcinoma (a or=14.37; 95% ci=3.77-54.76; p<0.001) and neuroendocrine carcinoma (a or=21.31; 95% ci=6.65-68.37, p<0.001) histological types were associated with a higher risk for cm development.Cm risk was higher in the first years of follow-up, with no cases observed after the 6th year.Conclusion cc patients in advanced clinical stages, displaying previous lung metastasis and non-squamous histological types are at high risk of developing cm.

Journal: Journal of gynecologic oncology (2022)
Publication types: Journal Article;Observational Study