syedzayyan/paper_mill_benchmark huggingface dataset:
Linkage-to-Care Following Community-Based HBV and HCV Screening Among Immigrants from the Washington-Baltimore Metropolitan Area, 2016-2019.

Understanding characteristics that impact linkage-to-care (ltc) among individuals living with hbv and/or hcv can enhance public health efforts to provide tailored care services to prevent and treat viral hepatitis among immigrants.Using hbv/hcv screening and ltc data from immigrants (2016-2019), descriptive and logistic regression analyses were conducted to assess (1) the relationship between ltc and sociodemographic factors and (2) factors associated with hbv/hcv ltc.About 87% of those positive hbs ag had ltc and 52% had ltc among those with hcvab and confirmed pcr.Access to care was an important ltc predictor for hbv-ltc: those who had neither health insurance nor primary care provider (pcp) were more likely to have hbv-ltc than those who had either health insurance or pcp (a or = 2.95, 95% ci = 1.32-6.59).It is essential to equally provide hbv/hcv ltc support to all immigrants from countries with high prevalence regardless of access to care.

Journal: Journal of immigrant and minority health (2022)
Publication types: Journal Article
Short-Wave Infrared Emitting Nanocomposites for Fluorescence-Guided Surgery.

Fluorescence-guided surgery (fgs) is an emerging technique for tissue visualization during surgical procedures.Structures of interest are labeled with exogenous probes whose fluorescent emissions are acquired and viewed in real-time with optical imaging systems.This study investigated rare-earth-doped albumin-encapsulated nanocomposites (reancs) as short-wave infrared emitting contrast agents for fgs.Experiments were conducted using an animal model of 4t1 breast cancer.The signal-to-background ratio (sbr) obtained with reancs was compared to values obtained using indocyanine green (icg), a near-infrared dye used in clinical practice.Prior to resection, the sbr for tumors following intratumoral administration of reancs was significantly higher than for tumors injected with icg.Following fgs, evaluation of fluorescence intensity levels in excised tumors and at the surgical bed demonstrated higher contrast between tissues at these sites with reanc contrast than icg.Reancs also demonstrated excellent photostability over 2 hours of continuous illumination, as well as the ability to perform fgs under ambient lighting, establishing these nanocomposites as a promising contrast agent for fgs applications.

Journal: IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society (2021)
Publication types: Journal Article
Arecae pericarpiumwater extract alleviates chronic pancreatitis by deactivating pancreatic stellate cells.

Chronic pancreatitis (cp) is a chronic inflammatory disease of the pancreas with irreversible morphological changes.arecae pericarpium(arp), known to improve gastrointestinal disorders, has not yet been reported to inhibit fibrosis in cp.Therefore, we investigated the beneficial effects of arp on cerulein-induced cp.Cerulein (50 μg/kg) was administered intraperitoneally to mice every hour, six times a day, four times a week for a total of 3 weeks to induce cp.To ascertain the prophylactic effects of arp, arp water extract (50, 100, or 200 mg/kg) or saline was administered intraperitoneally 1 h before the onset of cp.To determine the therapeutic effects of arp, arp water extract (200 mg/kg) or saline was administered for a total of 1 week or 2 weeks, starting 2 weeks or 1 week after the onset of cp.The pancreas was collected immediately for histological analysis.Additionally, to determine the effectiveness and mechanism of arp in alleviating pancreatic fibrosis, pancreatic stellate cells (pscs) were isolated.Arp treatment considerably improved glandular atrophy and inflammation and repressed collagen deposition in the pancreas.Furthermore, arp water extract inhibited extracellular matrix (ecm) constituents such as alpha-smooth muscle actin (α-sma), collagen i, and fibronectin 1 (fn1) in pancreatic tissue and pscs.Arp also suppressed transforming growth factor-β (tgf-β) signaling by inhibiting smad2 phosphorylation.Our study suggests that arp exhibits anti-fibrotic effects in cerulein-induced cp by inhibiting tgf-β/smad signaling.

Journal: Frontiers in pharmacology (2022)
Publication types: Journal Article
Evaluation of circulating microRNAs as non-invasive biomarkers in the diagnosis of ovarian cancer: a case-control study.

Ovarian cancer is the seventh most frequent form of malignant diseases in women worldwide and over 150,000 women die from it every year.More than 70 percent of all ovarian cancer patients are diagnosed at a late-stage disease with poor prognosis necessitating the development of sufficient screening biomarkers.Micro rnas displayed promising potential as early diagnostics in various malignant diseases including ovarian cancer.The presented study aimed at identifying single micro rnas and micro rna combinations detecting ovarian cancer in vitro and in vivo.Methods intracellular, extracellular and urinary micro rna expression levels of twelve micro rnas (let-7a, let-7d, mi r-10a, mi r-15a, mi r-15b, mi r-19b, mi r-20a, mi r-21, mi r-100, mi r-125b, mi r-155, mi r-222) were quantified performing quantitative real-time-pcr.Therefore, the three ovarian cancer cell lines sk-ov-3, oaw-42, efo-27 as well as urine samples of ovarian cancer patients and healthy controls were analyzed.Results mi r-15a, mi r-20a and mi r-222 showed expression level alterations extracellularly, whereas mi r-125b did intracellularly across the analyzed cell lines.Micro rna expression alterations in single cell lines suggest subtype specificity in both compartments.Hypoxia and acidosis showed scarce effects on single mi rna expression levels only.Furthermore, we were able to demonstrate the feasibility to clearly detect the 12 mi rnas in urine samples.In urine, mi r-15a was upregulated whereas let-7a was down-regulated in ovarian cancer patients.Conclusion intracellular, extracellular and urinary micro rna expression alterations emphasize their great potential as biomarkers in liquid biopsies.Especially, mi r-15a and let-7a qualify for possible circulating biomarkers in liquid biopsies of ovarian cancer patients.

Journal: Archives of gynecology and obstetrics (2022)
Publication types: Journal Article
BaRTv2: a highly resolved barley reference transcriptome for accurate transcript-specific RNA-seq quantification.

Accurate characterisation of splice junctions (sjs) as well as transcription start and end sites in reference transcriptomes allows precise quantification of transcripts from rna-seq data, and enables detailed investigations of transcriptional and post-transcriptional regulation.Using novel computational methods and a combination of pac bio iso-seq and illumina short-read sequences from 20 diverse tissues and conditions, we generated a comprehensive and highly resolved barley reference transcript dataset from the european 2-row spring barley cultivar barke (ba rtv2.18).Stringent and thorough filtering was carried out to maintain the quality and accuracy of the sjs and transcript start and end sites.Ba rtv2.18 shows increased transcript diversity and completeness compared with an earlier version, ba rtv1.0.The accuracy of transcript level quantification, sjs and transcript start and end sites have been validated extensively using parallel technologies and analysis, including high-resolution reverse transcriptase-polymerase chain reaction and 5'-race.Ba rtv2.18 contains 39 434 genes and 148 260 transcripts, representing the most comprehensive and resolved reference transcriptome in barley to date.It provides an important and high-quality resource for advanced transcriptomic analyses, including both transcriptional and post-transcriptional regulation, with exceptional resolution and precision.

Journal: The Plant journal : for cell and molecular biology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
What is the future of treatment de-escalation for HPV-positive oropharyngeal cancer? A review of ongoing clinical trials.

Human papillomavirus (hpv)-associated oropharyngeal squamous cell carcinoma (opscc) has increased in incidence in recent decades.With higher cure rates in younger populations, long-term survivors may live with acute- and long-term toxicity, leading to increased interest in de-escalation treatment strategies for hpv-related opscc.Herein, we have examined the current landscape of clinical trials in this context.Methods a review of active clinical trials related to de-escalation of hpv-associated opscc treatment was performed using the clinicaltrials.gov database from inception to january 2022.A search using the key words "oropharyngeal cancer" and "hpv" was completed.Three investigators independently reviewed each trial, with any discrepancies settled by a fourth.Data collected from each study included study phase, study design, primary, and secondary endpoints, and de-escalation treatment strategies.A final 24 articles were selected for full text review.Results many trials (n=19, 79%) were non-randomized, and most studies employed a phase ii design (n=14, 58%).Only 13% (n=3) were randomized trials, and 8% (n=2) included a phase iii component.The most frequent primary endpoint was progression-free survival (pfs) (n=9, 37.5%).With regards to the identified de-escalation strategies, all the studies (n=24) had at least one component assessing changes in rt dose/fractionation and/or a reduction in rt volumes.A smaller percentage of trials assessed surgical interventions (n=9, 37.5%) and/or changes in systemic therapy (n=8, 33.3%).Conclusion a small number of randomized trials are underway, and a transition to more randomized phase iii trials in the future will be important to change clinical practice.

Journal: Frontiers in oncology (2022)
Publication types: Journal Article
The Willingness to Donate Organs in Medical Students From an International Perspective: A Meta-Analysis.

Attitude toward organ donation mobilizes donation behavior and makes transplant surgery possible.As future health professionals, medical students will be a relevant generating opinion group and will have an important role in the organ requesting process.The goals of this meta-analysis were to obtain polled rates of medical students who are in favor, against, or indecisive toward cadaveric organ donation in the studies conducted around the world, and to explore sociocultural variables influencing the willingness to donate.Electronic search and revision of references from previous literature allowed us to locate 57 studies fulfilling the inclusion criteria.Data extraction and risk of bias assessment were performed by two independent investigators.Pooled estimations were computed assuming a random-effects model.Despite the fact that willingness to donate was elevated in medical students, estimated rates in studies from different geographical areas and sociocultural backgrounds exhibited significant differences.The age and the grade of the students also influenced the rate of students in favor.Donation campaigns should take into account cultural factors, especially in countries where certain beliefs and values could hamper organ donation.Also, knowledge and skills related to organ donation and transplant should be acquired early in the medical curriculum when a negative attitude is less resistant to change.

Journal: Transplant international : official journal of the European Society for Organ Transplantation (2022)
Publication types: Journal Article;Meta-Analysis;Review
Cytotoxic polyhydroxylated pregnane glycosides fromCissampelos pareiravar.hirsuta.

Fourteen new polyhydroxylated pregnane glycosides, cissasteroid a-n (1-14), and five known analogues (15-19), were isolated from the dried whole plant of cissampelos pareiravar.hirsuta.Their structures and stereochemistry were elucidated by extensive spectroscopic data, chemical hydrolysis, and ecd measurements.All the compounds were tested for their cytotoxicity against five human cancer cell lines, and inhibitory activity against no release in lps-induced raw 264.7 cells.Compared with cisplatin, compound 7 showed more potent cytotoxicities against the hl-60, a549, smmc-7721, mcf-7, and sw480 cell lines, with ic50values of 2.19, 14.38, 2.00, 7.58, and 7.44 μm, respectively.The preliminary study of structure-activity relationship indicated that benzoic acid esterification at c-20 may have a negative effect on the cytotoxic activity of polyhydroxylated pregnane derivatives in these five human cancer cell lines.These results revealed the potential of compound 7 as an ideal antitumor lead compound.

Journal: RSC advances (2021)
Publication types: Journal Article
Determinants of willingness to accept child vaccination against malaria in Ghana.

Malaria is a public health problem in ghana with children being one of the most vulnerable.Given this, in 2019, ghana decided to add the first malaria vaccine (rts, s) as part of routine immunisations for children in the near future.This study, thus, examines the determinants of malaria vaccine awareness and willingness to uptake the vaccine for children in ghana.Method the study uses data from the 2019 ghana malaria indicator survey while employing the binary logistic regression as the empirical estimation technique.Results the study finds that religion, region of residence and awareness of the malaria vaccine, influence the willingness to uptake the vaccine for children.Moreover, younger mothers (15-26 years), households in the richest wealth quintile, male-headed households and the number of children aged five years and below in a household, are found to be associated with less willingness to uptake the vaccine for children.Conclusion paying attention to awareness creation, region, religion, younger mothers (15-26 years), households in the richest wealth quintile, male-headed households and households with more children aged five years and below, can ensure optimal uptake of the malaria vaccine for children in ghana.

Journal: The International journal of health planning and management (2022)
Publication types: Journal Article
'What matters to you?' Normative integration of an intervention to promote participation of older patients with multi-morbidity - a qualitative case study.

Interventions in which individual older patients with multi-morbidity participate in formulating goals for their own care are being implemented in several countries.Successful service delivery requires normative integration by which values and goals for the intervention are shared between actors at macro-, meso- and micro-levels of health services.However, health services are influenced by multiple and different institutional logics, which are belief systems guiding actors' cognitions and practices.This paper examines how distinct institutional logics materialize in justifications for patient participation within an intervention for patients with multi-morbidity, focusing on how variations in the institutional logics that prevail at different levels of health services affect vertical normative integration.Methods this qualitative case study of normative integration spans three levels of norwegian health services.The macro-level includes a white paper and a guideline which initiated the intervention.The meso-level includes strategy plans and intervention tools developed locally in four municipalities.Finally, the micro-level includes four focus group discussions among 24 health professionals and direct observations of ten care-planning meetings between health professionals and patients.The content analysis draws on seven institutional logics: professional, market, family, community, religious, state and corporate.Results the particular institutional logics that justified patient participation varied between healthcare levels.Within the macro-level documents, seven logics justified patients' freedom of choice and individualization of service delivery.At meso-level, the operationalization of the intervention into tools for clinical practice was dominated by a state logic valuing equal services for all patients and a medical professional logic in which patient participation meant deciding how to maintain patients' physical abilities.At micro-level, these two logics were mixed with a corporate logic prioritizing cost-efficient service delivery.Conclusion normative integration is challenging to achieve.The number of institutional logics in play was reduced downwards through the three levels, and the goals behind the intervention shifted from individualization to standardization.The study broadens our understanding of the dynamic between institutional logics and of how multiple sets of norms co-exist and guide action.Knowledge of mechanisms by which normative justifications are put into practice is important to achieve normative integration of patient participation interventions.

Journal: BMC health services research (2021)
Publication types: Journal Article
Insights about interventions to address food insecurity in adults with type 2 diabetes: Valuable lessons from the stories of African Americans living in the inner city.

S this qualitative study aimed to gain insight from the perspectives of food insecure african americans living in an inner city regarding important diabetes intervention strategies and components.Methods using a grounded theory approach, two focus groups (totaling 16 individuals) were conducted in milwaukee, wisconsin.Purposive, convenience sampling was used to identify food insecure adults with diabetes.Questions were asked using a moderator guide to explore challenges and barriers to managing diabetes within the context of food insecurity, and facilitators or resources that helped participants improve diabetes management.Questions were open ended and followed by probes asking for additional perspectives and personal experiences related to the overarching topic, and questions asking to clarify statements.Results overarching concepts and themes specific to possible interventions discussed during the focus groups included group education, peer support, access to community resources and programs, stress management, and faith-based programs as desired intervention outcomes.Conclusions key findings from the current study show that inner-city african americans with diabetes desire interventions that foster social and community support systems.Practice implications given this insight, more robust and comprehensive interventions are needed to account for the multifaceted experience of food insecurity and diabetes within the inner-city environment.

Journal: Patient education and counseling (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Self-crosslinked chitosan/dialdehyde xanthan gum blended hypromellose hydrogel for the controlled delivery of ampicillin, minocycline and rifampicin.

The design of improved biopolymeric based hydrogel materials with high load-capacity to serve as biocompatible drug carriers is a challenging task with vital implications in health sciences.In this work, chitosan crosslinked dialdehyde xanthan gum interpenetrated hydroxypropyl methylcellulose gels were developed for the controlled delivery of different antibiotic drugs including ampicillin, minocycline and rifampicin.The prepared hydrogel scaffolds were characterized by rheology method, ftir, sem, tga and compression analysis.In addition, gelation kinetics, swelling, in vitro degradation and drug release rate were studied under simulated gastrointestinal fluid conditions of p h 2.0 and 7.4 at 37 °c.Results demonstrated the gel composition and structure affected drug release kinetics.The release study showed more than 50% cumulative release within 24 h for all investigated antibiotic drugs.In vitro cell cytocompatibility using mouse embryonic fibroblast cell lines depicted ≥80% cell viability, indicating the gels are non-toxic.Finally, the antibacterial activity of loaded gels was evaluated against gram-negative and positive bacteria (escherichia coli, staphylococcus aureus and klebsiella pneumonia), which correlated well with swelling and drug release results.Overall, the present study demonstrated that the produced hydrogel scaffolds serves as promising material for controlled antibiotic delivery towards microbial growth inhibition.

Journal: International journal of biological macromolecules (2021)
Publication types: Journal Article
Biodegradation of Petroleum Hydrocarbons byDrechsleraspiciferaIsolated from Contaminated Soil in Riyadh, Saudi Arabia.

Currently, the bioremediation of petroleum hydrocarbons employs microbial biosurfactants because of their public acceptability, biological safety, and low cost.These organisms can degrade or detoxify organic-contaminated areas, such as marine ecosystems.The current study aimed to test the oil-biodegradation ability of the fungus drechslera spicifera, which was isolated from contaminated soil samples in riyadh, saudi arabia.We used hydrocarbon tolerance, scanning electron microscopy, dcpip, drop-collapse, emulsification activity, recovery of biosurfactants, and germination assays to assess the biodegradation characteristics of the d.Spiciferaagainst kerosene, crude, diesel, used, and mixed oils.The results of dcpip show that the highest oxidation (0.736 a.u.) was induced by crude oil on the 15th day.In contrast, kerosene and used oil had the highest measurements in emulsification activity and drop-collapse assays, respectively.Meanwhile, crude and used oils produced the highest amounts of biosurfactants through acid precipitation and solvent extraction assays.Furthermore, the biosurfactants stimulated the germination of tomato seeds by more than 50% compared to the control.These findings highlight the biodegradation ability of d.Spicifera, which has been proven in the use of petroleum oils as the sole source of carbon.That might encourage further research to demonstrate its application in the cleaning of large, contaminated areas.

Journal: Molecules (Basel, Switzerland) (2022)
Publication types: Journal Article
The impact of packaging recyclable ability on environment: Case and scenario analysis of polypropylene express boxes and corrugated cartons.

With the push for sustainable design strategies, recyclable packaging is widely favored by the public in the express delivery industry due to its potential for lowering environmental burden and solving climatic challenges.The goal of this paper was to quantify and integrate the environmental footprints of polypropylene hollow board express box (pph-eb) and establish evaluation model between the recyclable ability and environment performance (emre) based on life cycle assessment.This work was carried out by multiple indicators to avoid environmental problem-shifting, and corrugated cartons express box (c-eb) was taken as control objects.The results show that integrated index of pph-eb is 94.42% lower than that of c-eb.Industrial water use (iwu), primary energy demand (ped) and so2are major factors affecting results of pph-eb, which mainly come from polypropylene particles and water resource consumption from recycle process.The most obvious advantage of pph-eb compared with c-eb is the nearly 1700 times difference in normalized cod index caused by direct emission of paper preparation process.Scenario analysis showed that integrated index of pph-eb was lower than that of traditional corrugated cartons after more than twice of use, but if the recycling times of pph-eb continued to increase, the effect on reducing environmental burden was no longer significant.Therefore, although the recyclable times plays a role in decreasing the environmental impact, it is not a permanent strategy.In the design stage of the recyclable express box, the recyclable ability should be reasonably designed through emre, so as to minimize the environmental burden.

Journal: The Science of the total environment (2022)
Publication types: Journal Article