syedzayyan/paper_mill_benchmark huggingface dataset:
The Role of ET-1 in Early Cerebral Microcirculation Changes after Subarachnoid Hemorrhage

Subarachnoid hemorrhage (sah), especially aneurysmal subarachnoid hemorrhage, is a serious cerebrovascular disease with high mortality and morbidity.However, there is no effective treatment in clinics.In recent years, more and more studies have shown that early brain injury (ebi) may be an important reason for poor prognosis of sah.Explore the mechanism of early brain injury after subarachnoid hemorrhage (sah).In this study, 20 male new zealand white rabbits were selected and divided into the experimental group and sham operation group, with 10 rabbits in each group.The neurobehavioral scores, food intake, and cerebral perfusion parameters, cerebral blood volume (cbv), cerebral blood flow velocity (cbf), et-1, il-1, and il-6, in rabbit plasma were compared.The food intake scores and neurological dysfunction scores of the experimental group at 1 h, 6 h, 24 h, and 72 h after modeling were higher than those of the sham operation group, which had a statistical significance ( p &lt; 0.05 ).The dysfunction scores all showed a gradual decrease; the cbv and cbf values of the experimental group at 1 h, 6 h, 24 h, and 72 h after modeling were all lower than those of the sham operation group, which had a statistical significance ( p &lt; 0.05 ), and the mtt values were all higher than that of the sham operation group, which had a statistical significance ( p &lt; 0.05 ).The ttp values of rats in the experimental group were higher than those in the sham operation group at 6 h, 24 h, and 72 h after modeling ( p &lt; 0.05 ), the experimental group was in the modeling.The levels of serum et-1, il-1, and il-6 at 1 h, 6 h, 24 h, and 72 h were higher than those in the sham operation group, which had a statistical significance ( p &lt; 0.05 ).New zealand white rabbits can have brain perfusion volume disorder, inflammatory reaction, and cerebral vasospasm in the early stage after sah, and brain injury can appear in the early stage.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Walking and Activeness: The First Step toward the Prevention of Strokes and Mental Illness

Physical activity, especially routine walking, is an imperative factor for the prevention of strokes, mental illness, and cardiovascular diseases (cvds).The nih (national institute of health) has also acknowledged walking as the most important factor of the stroke rehabilitation program.Many research studies are presented by physicians and researchers in the literature that highlight the positive impacts of walking on human health (physical and mental).This paper has the objective of studying the impact of regular walking, especially on mental illness, cvds, and strokes.The c-reactive protein (crp), p-selectin protein, and homocysteine biomarkers are considered to decide the improvement in the health of an individual with respect to cvds and strokes.The other parameters considered for the recommendations of physicians and healthcare experts for mental health are pss (perceived stress score) and ess (epworth sleepiness score) that control mental illness.The values are measured for the participating subjects before participating in the walking activity and after the end of the walking schedule to see the impact on individuals.The overall mental and physical health of an individual contributes to the chances of occurrence of cvds, mental illness, and strokes in individuals aged between 40 years and 55 years, as per the study presented in this paper.The results show that the pss and ess scores are improved after the walking activity.Eventually, it improved recovery from many kinds of mental illness and also reduced the chances of strokes.Similarly, the levels of the biomarkers that determine the chances of an individual having cvd or stroke also improved.Walking can impact our overall health in many ways, however, in this paper, the focus is given to ailments, such as strokes, cvds, and mental illness.The results show that stress and improper sleepiness can impact mental health negatively.The research outcome is measured by adding walking in a routine life so that every individual can get rid of many physical and mental ailments.The results presented in the paper reveal that the 90-day walking program has created a good impact on the health of individuals by improving their physical and mental health.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
The Relationship between Ultrasonographic Features of Hepatocellular Carcinoma and the Severity of Hepatocellular Carcinoma and the Expression of PTEN and Tg737

To investigate the relationship between the ultrasonographic features of hepatocellular carcinoma (hcc) and the severity of hcc and the expression of tumor suppressor genes pten and tg737, 90 patients with primary liver cancer are selected as the study subjects.The enhancement of liver tumor in arterial phase, portal venous phase, and delayed phase is observed by contrast-enhanced ultrasound (ceus) before operation, and the echo intensity is compared with that of surrounding liver parenchyma.Immunohistochemistry is used to detect the expression of pten and tg737 in hepatocellular carcinoma and paracancerous tissues.(1) in hcc, ceus enhancement is characterized by rapid enhancement in arterial phase, enhancement in portal venous phase and delayed phase, and decreased hypoechoic changes.About 78.0% of the stage i-ii liver cancer and 85.0% of the stage iii-iv liver cancer show rapid enhancement and high echo in the arterial phase; only 8.0% of the stage i-ii liver cancer shows moderate echo changes in the portal venous phase, while 32.5% (13/40) stage iii-iv liver cancer shows moderate echo changes in the portal venous phase.(2) the positive rates of pten in liver cancer tissues and paracancerous tissues are 21.1% (19/90) and 70.0% (63/90), respectively, and the difference is statistically significant.The positive rates of tg737 in liver cancer tissues and paracancerous tissues are 17.8% (16/90) and 75.6% (68/90), respectively, and the difference is statistically significant.Compared with pten and tg737 negative groups, the ascending slope (rs) and initial elimination time (wt) of pten and tg737 positive groups are significantly higher, indicating that the inflow velocity of contrast medium in the positive group is higher, the outflow time is shorter, and the lesions shows low enhancement rapidly.However, the expression of pten and tg737 had no significant difference in maximal intensity (imax), peak time (ttp), and mean transit time (m tt).(3) correlation analysis shows that the immunohistochemical scores of pten and tg737 are not significantly correlated with imax, m tt, and ttp but positively correlated with rs (r = 0.359, p &lt; 0.05), suggesting that the positive expressions of pten and tg737 are negatively correlated with the inflow velocity of contrast medium.The immunohistochemical scores of pten and tg737 are negatively correlated with wt, which indicated that the higher the expression intensity of pten is, the longer the outflow time of contrast medium is and the slower the outflow of contrast medium is.There is a significant correlation between the expression of pten and tg737 proteins and ceus parameters in hepatocellular carcinoma.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
The Relationship between Insomnia and Internal Carotid Artery Stenosis and Cognitive Dysfunction by Magnetic Sensitivity Weighted Imaging Based on Wireless Network Communication

The paper analyzes the detection of insomnia and carotid artery stenosis by magnetic sensitivity weighted imaging (swi) based on radio communication and its relationship with cognitive dysfunction.A total of 148 patients with carotid artery stenosis and insomnia admitted to our hospital from january 2020 to june 2021 are selected.According to different detection methods, wireless communication combined with swi group and conventional group are established respectively, with 74 cases in each group.The conventional group applies ct angiography (cta) is in line with the intervention mode of patients complaining of sleep at night.In the wireless communication combined with swi group, the sleep monitoring system of wireless communication combined with swi detection method is used to observe the imaging detection rate, insomnia detection rate and diagnostic efficiency of the two groups.The differences of psg index parameters, sleep quality (psqi) score and cognitive function (mo ca) score of patients with different disease degrees are compared.Pearson correlation coefficient is used to analyze the correlation between psqi score and mo ca score.Swi sequence scan based on wireless network communication has high efficiency in the diagnosis of carotid artery stenosis, and the sleep status of patients can be better understood by real-time monitoring of patients, which is of great significance for the follow-up development of effective diagnosis and treatment plans and recovery of patients’ cognitive function, and worthy of clinical application.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
The Practical Application of Oil Painting in the Treatment of Mental Illness

With the rapid development of economy, politics, science, and technology and the improvement of living material level, people pay more attention to personal physical and mental development.The incidence of mental illness is on the rise.Psychological education curriculum learning and psychological counselling are based on communication; there are still many limitations.The art media enables patients to reveal their subconscious and potential emotional needs, so that interveners have the opportunity to explore these issues and build a bridge of communication with patients.In this paper, oil painting therapy of nonverbal communication is proposed as a way of psychological therapy.The patients in the psychological department of a hospital are served by six stages of therapy, each stage of treatment has different arrangements, and continuous service and treatment are adopted.Based on the art analysis principle of oil painting creation, the therapeutic experience obtained from oil painting creation and the experience gained from oil painting were divided into groups to compare the therapeutic effect and explore the role of oil painting art therapy.The results showed that the scores of the treatment group were significantly lower than those of the control group at 4 weeks and 6 weeks after the art therapy of oil painting creation, showing a significant downward trend overall.Oil painting art therapy may alleviate anxiety, providing data support for the application of oil painting art therapy in patients with depressive episodes.

Journal: Occupational Therapy International (2022)
Publication types: Research Article;
The Effect of the Integrated Chinese and Western Medicine for the Treatment of Parkinson’s Disease: A Meta-Analysis

Traditional chinese medicine (tcm) has been used to treat parkinson’s disease (pd), but the efficacy is still not clear.The aim of this study was to evaluate the effect of the integrated chinese and western medicine (icwm) for pd through a meta-analysis.Methods.We searched randomized controlled trials comparing integrated chinese and western medicine (icwm) versus conventional western medicine (cwm) for parkinson’s disease.Data were extracted from eligible studies.We sought to evaluate pretreatment and posttreatment symptoms of pd patients and their quality of life and reduce adverse reactions.The results were expressed as risk ratio (rr) and mean difference (md) with accompanying 95% confidence intervals.Results.Twenty-three studies were included in this study with a total of 1769 patients.The pooled results revealed that icwm significantly improved the updrs score than cwm, the md of updrs-i, ii, iii, and iv was -1.05 (95% ci: -1.42 to -0.69, p &lt; 0.00001 ), -2.55 (95% ci: -3.19 to -1.90, p &lt; 0.00001 ), -3.64 (95% ci: -4.69 to -2.60, p &lt; 0.00001 ), and -0.61 (95% ci: -0.96 to -0.27, p = 0.0004 ), respectively, and icwm also had a better score of pdq-39 ( md = − 8.71 , 95% ci: -13.52 to -3.90, p = 0.0004 ) and mo ca scores ( md = 3.35 , 95% ci: 1.65 to 5.04, p = 0.0001 ) compared with cwm.Icwm had certain advantages in terms of effective rate ( rr = 1.27 , 95% ci: 1.18 to 1.37, p &lt; 0.00001 ) and adverse reactions ( rr = 0.21 , 95% ci: 0.13 to 0.36, p &lt; 0.00001 ).Conclusion.Our research supported that icwm had important health benefits for patients with pd and can effectively improve the symptoms of pd patients and their quality of life and reduce adverse reactions.Due to the lower quality of the included studies, large sample and multicenter randomized control test should be performed to verify our conclusions.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Meta-Analysis;
The Application Value of SMI Technology and Contrast-Enhanced Ultrasound in the Differential Diagnosis of Benign and Malignant Thyroid Nodules

Thyroid disease has always been a common and frequent disease in clinical medicine, and its disease detection rate has been increasing year by year.Thyroid diseases are mainly divided into two categories: thyroid diseases treated by medical treatment and thyroid diseases treated by surgery.Thyroid cancer has also become one of the most common malignant secretory tumor diseases today.Ultrasound examination is a commonly used method for diagnosing thyroid diseases.During the diagnosis process, doctors need to observe the characteristics of ultrasound images and combine professional knowledge and clinical experience to give the patient’s disease status.With the improvement of people’s living standards and health awareness, thyroid disease has become an important issue that plagues the health of chinese residents.Therefore, people and medical workers are paying more attention to thyroid disease.In recent years, various ultrasound technologies have been applied in the differential diagnosis of benign and malignant thyroid nodules and have played an important role in the diagnosis.This article aims to study the application value of smi technology (ultra‐microvascular imaging technology) and contrast‐enhanced ultrasound in the differential diagnosis of thyroid benign and malignant nodules.It conducts diagnostic experiments and analysis on some cases of benign and malignant thyroid nodules through the use of smi diagnostic methods and contrast‐enhanced ultrasound examination methods.And the roc curve was used to calculate the sensitivity of smi technology and ultrasound for the identification and diagnosis of thyroid benign and malignant nodules, and the results were 0.83 and 0.81, respectively.It is concluded that smi technology and contrast‐enhanced ultrasound examination have good diagnostic efficiency and application value for the identification and diagnosis of thyroid benign and malignant nodules.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Technical Evaluation of Commercial Sperm DFI Quality Control Products in SCSA Testing

With the increase in population and the advancement of medicine, people even more hope that their offspring will be healthier.Dna fragmentation rate is currently one of the more common indicators for evaluating sperm fertility and predicting the outcome of pregnancy.In order to evaluate the technical performance and application value of commercial sperm dfi (dna fragmentation index) quality control products in the flow cytometry sperm chromatin structure analysis (scsa), this paper uses flow cytometry to test commercial sperm dfi quality control products (celula) and laboratory routine self-made dfi quality control products.In this paper, the quality control of new commercial sperm dfi and laboratory-made quality control were compared and tested for 30 consecutive days.And this paper monitors the response of commercial quality control products to the interference of key reagent parameters.This paper compares the stability of the test results of two quality control products and their sensitivity to the interference of key performance parameters of the detection reagent.Experimental results show that commercial sperm dfi quality control products can simulate sperm dna damage to achieve accurate detection of dna integrity.The stability of commercial sperm dfi quality control (cv = 2.47%) is better than that of laboratory-made quality control (cv = 11.22%).The new commercial sperm dfi quality control product can sensitively detect changes in the concentration of acidified solution and staining solution at the same time.It can effectively control the quality of detection reagents and experimental procedures.The new commercial sperm dfi quality control product can effectively control sperm dna integrity testing.It can be used as an external quality control product for quality control of test results to ensure that more accurate test results are provided to the clinic.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Study on Syndrome Intervention of Nonalcoholic Fatty Liver Disease from the Perspective of Deficiency and Excess

During the onset of nonalcoholic fatty liver disease (nafld), the original deficiency is the root cause of its occurrence, and the actual condition is the basic condition for its occurrence.Therefore, the correlation between the deficiency and the actual condition is the basic law of nafl syndrome formation, pathogenesis, development, and change.Based on this, the purpose of this article is to study and analyze the syndrome intervention of nafld from the perspective of the original deficiency and the true standard.In this article, the tcm physical fitness determination and related risk factors investigation were conducted on qualified nafld patients collected from outpatient clinics and physical examination centers of a certain local hospital.Analyze the correlation between the physique bias, physique type, and risk factors of nafld patients, in order to effectively carry out chinese medicine “preventive treatment” in the future.Predicting the risk of nonalcoholic fatty liver disease from the perspective of physique, more targeted health education for nafld patients with risk factors, reducing the risk of nonalcoholic fatty liver disease, and providing evidence for prevention and treatment of fatty liver.The research in this article aims to show a clearer conclusion on the structural characteristics of nafld’s syndromes related to the deficiency of the original standard and the actual syndromes or the syndromes related to the original deficiency of the standard of the actual syndromes; nafld has the characteristics of being related to the original deficiency and the actual standard, and the relationship between the original deficiency and the actual standard has different syndromes, and the relationship between the original deficiency and the actual standard can also show the characteristics of different subsyndromes.Experimental research shows that people with hot and humid constitution are prone to suffer from hyperglycemia, intermediate coke hot and heat obstruction, spleen and stomach clearance, and turbidity reduction function is impaired, and the migration and transformation of water and valley essence after the stomach is uneven, leading to the stagnation of water, wet, phlegm, blood stasis, and other pathological products.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Relationship between Long Noncoding RNA H19 Polymorphisms and Risk of Coronary Artery Disease in a Chinese Population: A Case-Control Study

/aim .Coronary artery disease (cad) is a major health problem that has high morbidity and mortality around the world.In recent years, long noncoding rna h19 has been reported to affect the proliferation and apoptosis of vascular cells, which directly or indirectly results in atherosclerosis.We performed a case-control study to explore the relationship between h19 gene polymorphisms (rs2735971, rs2839698, and rs3024270) and the risk of cad.Methods .We collected 732 samples from liaoning province, china, and three polymorphisms in long noncoding rna h19 were genotyped using the kasp platform.Results .Our data showed that h19 rs2735971 and rs3024270 variant genotypes were associated with a decreased risk of cad (rs2735971, p = 0.003 , odds ratio or = 0.6195 , 95 % confidence interval = 0.44 − 0.84 ; rs3024270, p = 0.030 , or = 0.65 , 95 % confidence interval = 0.44 − 0.96 ).No significant association with the risk of cad was found for h19 rs2839698 polymorphism ( p &gt; 0.05 ).In haplotype analysis, h19 polymorphisms of rs2735971-rs2839698-rs3024270 a-c-c haplotype reduced the risk of cad by 0.61-fold ( p = 0.004 , or = 0.61 , 95 % confidence interval = 0.43 – 0.86 ).In addition, we found that rs2839698 interacted with smoking ( p interaction = 0.027 ), and according to multifactor dimensionality reduction analysis, the three-factor model including h19 rs2839698-smoking-drinking was the best model for the risk of cad (testing balanced accuracy = 0.6979 ).Conclusion .Our study demonstrated that some genotypes of h19 rs2735971 and rs3024270 polymorphisms, as well as rs2735971-rs2839698-rs3024270 a-c-c haplotype, were associated with the risk of cad in a chinese population, and these genotypes have the potential to be biomarkers for predicting cad risk.We also found that rs2735971-rs2839698-rs3024270 a-c-c may have a significantly lower risk of cad.The recessive genetic model of rs3024270 could predict the severity of cad.

Journal: Disease Markers (2020)
Publication types: Research Article;
Preliminary Evaluation of Artificial Intelligence-Based Anti-Hepatocellular Carcinoma Molecular Target Study in Hepatocellular Carcinoma Diagnosis Research

In this paper, in‐depth research analysis of anti‐hepatocellular carcinoma molecular targets for hepatocellular carcinoma diagnosis was conducted using artificial intelligence.Because brd4 plays an important role in gene transcription for cell cycle regulation and apoptosis, tumor‐targeted therapy by inhibiting the expression or function of brd4 has received increasing attention in the field of antitumor research.Study subjects in small samples were used as the validation set for validating each diagnostic model constructed based on the training set.The diagnostic effect of each model in the validation set is evaluated by calculating the sensitivity, specificity, and compliance rate, and the model with the best and most stable diagnostic value is selected by combining the results of model construction, validation, and evaluation.The total sample was divided into a training set and test set by using a stratified sampling method in the ratio of 7 : 3.Logistic regression, weighted k ‐nearest neighbor, decision tree, and bp artificial neural network were used in the training set to construct diagnostic models for early‐stage liver cancer, respectively, and the optimal parameters of the corresponding models were obtained, and then, the constructed models were validated in the test set.To evaluate the diagnostic efficacy, stability, and generalization ability of the four classification methods more robustly, a 10‐fold crossover test was performed for each classification method.Brd4 is an epigenetic regulator that is associated with the upregulation of expression of various oncogenic drivers in tumors.Targeting brd4 with pharmacological inhibitors has emerged as a novel approach for tumor treatment.However, before we implemented this topic, there were no detailed studies on whether brd4 could be used for the treatment of hcc, the role of brd4 in hcc cell proliferation and apoptosis, and the ability of small molecule brd4 inhibitors to induce apoptosis in hepatocellular carcinoma cells.

Journal: BioMed Research International (2022)
Publication types: Research Article;