syedzayyan/paper_mill_benchmark huggingface dataset:
Research on the Selection of Chinese and Western Art Themes and Aesthetic Comparison Based on Computer Big Data

The theme is selected as the key of a painting to the success or failure, on the structure of the overall image is very important, also known as the “skeleton” paintings.In ancient china, people had already realized that subject selection was “the most important part of art works”, and paid much attention to the position of subject selection in the whole painting process.In the contemporary era, with the combination of computer big data technology, before painting, it is necessary to make choices and organize the picture with meticulous care and ingenuity, so as to achieve the overall harmony and unity of the picture.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
Innovative Research on New Media Interactive Art and Visual Communication Design Based on Computer Virtual Reality

Computer virtual technology is a new technology.It and new media are a new field.It and new media are a new field.They complement each other and are indispensable.In the face of more and more intelligent platforms, such as web pages, mobile apps, etc., designers pay more attention to user experience.Visual communication design no longer only refers to "visual" design, but should establish deeper links with the audience based on emotion, vision, hearing, touching and so on, so as to constantly meet new requirements and challenges.It can be said that the interactive art makes use of the audio-visual communication mode of traditional art, and carries out innovative reconstruction with the help of today’s technical conditions, realizing the perfect unity of inheriting tradition and bold innovation in form.[1]

Journal: Journal of Physics: Conference Series (2020)
Publication types: Conference Abstract/Paper;
Analysis of the Status Quo of Employment and Entrepreneurship of College Students in the New Era Based on Big Data Analysis and Discussion

With the continuous development of china’s social economy, the social demand for talent is increasing but due to the fierce competition between the markets, it also brings many problems for many college students’ employment and entrepreneurship.Employment and entrepreneurship of college students have become serious.Based on this, this article first analyzes the current situation of college students’ employment and entrepreneurship in the new era based on big data analysis, and then conducts an in-depth discussion on the development path of college students in the new era of employment and entrepreneurship.

Journal: Journal of Physics: Conference Series (2020)
Publication types: Conference Abstract/Paper;
Long non-coding RNA AGAP2-AS1, functioning as a competitive endogenous RNA, upregulates ANXA11 expression by sponging miR-16-5p and promotes proliferation and metastasis in hepatocellular carcinoma

Background accumulating evidence has highlighted the potential role of long non-coding rnas (lnc rnas) in the biological behaviors of hepatocellular carcinoma (hcc).Here, we elucidated the function and possible molecular mechanisms of the effect of lnc rna-agap2-as1 on the biological behaviors of hcc.Methods ed u, transwell and flow cytometry were used to determine proliferation, migration, invasion and apoptosis of hcc cells in vitro.The subcutaneous tumor model and lung metastasis mouse model in nude mice was established to detect tumor growth and metastasis of hcc in vivo.The direct binding of mi r-16-5p to 3’utr of anxa11 was confirmed by luciferase reporter assay.The expression of agap2-as1 and mi r-16-5p in hcc specimens and cell lines were detected by real-time pcr.The correlation among agap2-as1 and mi r-16-5p were disclosed by a dual-luciferase reporter assay, rip assay and biotin pull-down assay.Results here, we demonstrated that agap2-as1 expression was up-regulated in hcc tissues and cell lines, especially in metastatic and recurrent cases.Gain- and loss-of-function experiments indicated that agap2-as1 promoted cell proliferation, migration, invasion, emt progression and inhibited apoptosis of hcc cells in vitro and in vivo.Further studies demonstrated that agap2-as1 could function as a competing endogenous rna (ce rna) by sponging mi r-16-5p in hcc cells.Functionally, gain- and loss-of-function studies showed that mi r-16-5p promoted hcc progression and alteration of mi r-16-5p abolished the promotive effects of agap2-as1 on hcc cells.Moreover, anxa11 was identified as direct downstream targets of mi r-16-5p in hcc cells, and mediated the functional effects of mi r-16-5p and agap2-as1 in hcc, resulting in akt signaling activation.Clinically, agap2-as1 and mi r-16-5p expression were markedly correlated with adverse clinical features and poor prognosis of hcc patients.We showed that hypoxia was responsible for the overexpression of agap2-as1 in hcc.And the promoting effects of hypoxia on metastasis and emt of hcc cells were reversed by agap2-as1 knockdown.Conclusions taken together, this research supports the first evidence that agap2-as1 plays an oncogenic role in hcc via agap2-as1/mi r-16-5p/anxa11/akt axis pathway and represents a promising therapeutic strategy for hcc patients.

Journal: Journal of Experimental & Clinical Cancer Research: (CR) (2019)
Publication types: Research Article;
The Application of Innovation Mode in Building Engineering Management Based on Computer Technology

Buildings are one of the largest energy consumers in the world, and their energy consumption and greenhouse gas emissions account for one quarter to one third of the world’s total energy consumption.In addition, the building affects other areas far from its location, including river water, air quality and social traffic patterns.In china, more than 80% of new buildings are high energy consumption buildings every year, and more than 95% of existing buildings are high energy consumption buildings.At present, china’s energy consumption per unit floor area is more than 2-3 times that of developed countries.Through the corresponding computer technology application software, to create a simple building information model, architects in any stage of design, at any time, can easily evaluate the design scheme of the building, which is of great significance to the project management and construction of the building.

Journal: Journal of Physics: Conference Series (2020)
Publication types: Conference Abstract/Paper;
Analysis on the Innovation Hierarchy of Commercial Bank's Financial based on the Big Data

Financial products are derivative products of economic and social development in a certain period.Compared with state-owned enterprise banks, commercial banks have a greater dependence on the demand for financial products.Therefore, the innovation of financial products not only caters to the market and adapts to the times, but also has important significance for the development and survival of commercial banks.Based on the above background, this paper analyzes the impact of big data on financial services by combining computer big data technology, and puts forward suggestions for small and micro-enterprise financial product innovation of commercial banks based on computer big data in view of the current difficulties in financial product innovation of commercial banks.

Journal: Journal of Physics: Conference Series (2020)
Publication types: Conference Abstract/Paper;
Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis

We conducted a meta-analysis to comprehensively evaluate the correlations of ezrin expression with pathological characteristics and the prognosis of osteosarcoma.The medline (1966–2013), the cochrane library database, embase, cinahl, web of science (1945–2013), and the chinese biomedical database were searched without language restrictions.Meta-analyses conducted using stata software were calculated.Ten studies met the inclusion criteria, including 459 patients with osteosarcoma.Meta-analysis results illustrated that ezrin expression may be closely associated with the recurrence of osteosarcoma or metastasis in osteosarcoma.Our findings also demonstrated that patients with grade iii-iv osteosarcoma showed a higher frequency of ezrin expression than those with histological grade i-ii osteosarcoma.Furthermore, we found that patients with positive expression of ezrin exhibited a shorter overall survival than those with negative ezrin expression.The results also indicated that positive ezrin expression was strongly correlated with poorer metastasis-free survival.Nevertheless, no significant relationships were observed between ezrin expression and clinical variables (age and gender).In the current meta-analysis, our results illustrated significant relationships of ezrin expression with pathological characteristics and prognosis of osteosarcoma.Thus, ezrin expression could be a promising marker in predicting the clinical outcome of patients with osteosarcoma.

Journal: The Scientific World Journal (2014)
Publication types: Meta-Analysis;
Long non-coding RNA MEG3 silencing and microRNA-214 restoration elevate osteoprotegerin expression to ameliorate osteoporosis by limiting TXNIP

Studies have shown that long non‐coding rna (lnc rna) meg3 plays a key role in osteoporosis (op), but its regulatory mechanism is somewhat incompletely clear.Here, we intend to probe into the mechanism of meg3 on op development by modulating micro rna‐214 (mi r‐214) and thioredoxin‐interacting protein (txnip).Rat models of op were established.Meg3, mi r‐214 and txnip m rna expression in rat femoral tissues were detected, along with txnip, opg and rankl protein expression.Bmd, bv/tv, tb.n and tb.th in tissue samples were measured.Ca, p and alp contents in rat serum were also determined.Primary osteoblasts were isolated and cultured.Viability, col‐i, col‐ii and col‐χ m rna expression, pcna, cyclin d1, ocn, runx2 and osteolix protein expresion, alp content and activity, and mineralized nodule area of rat osteoblasts were further detected.Dual‐luciferase reporter gene and rna‐pull down assays verified the targeting relationship between meg3, mi r‐214 and txnip.Meg3 and txnip were up‐regulated while mi r‐214 was down‐regulated in femoral tissues of op rats.Meg3 silencing and mi r‐214 overexpression increased bmd, bv/tv, tb.n, tb.th, trabecular bone area, collagen area and opg expression, and down‐regulated rankl of femoral tissues in op rats.Meg3 silencing and mi r‐214 overexpression elevated ca and p and reduced alp in op rat serum, elevated osteoblast viability, differentiation ability, col‐i and col‐χ expression and alp activity, and reduced col‐ii expression of osteoblasts.Meg3 specifically bound to mi r‐214 to regulate txnip.Meg3 silencing and mi r‐214 overexpression promote proliferation and differentiation of osteoblasts in op by down‐regulating txnip, which further improves op.

Journal: Journal of Cellular and Molecular Medicine (JCMM) (2021)
Publication types: Research Article;
MicroRNA-150 Inhibits Cell Invasion and Migration and Is Downregulated in Human Osteosarcoma

Mi r-150 expression in osteosarcoma (os) cell lines and human osteoblast cells was detected, and os cell models were transfected with exogenous mi r-150 to investigate its role in cell proliferation, invasion, and apoptosis.Our results showed that mi r-150 expression in os cells (mg63, saos-2, sosp-9607, and u2os) was significantly lower compared to the osteoblast h fob1.19 cell line (all p &lt; 0.01).The expression level of mi r-150 in mg63 cells that were transfected with exogenous mi r-150 mimics was markedly upregulated, while the mi r-150 expression level in the inhibitor group was significantly downregulated (both p &lt; 0.01).Similar results were also found in sosp-9607 cells.Importantly, exogenous mi r-150 expression stimulated cell apoptosis and inhibited proliferation, invasion, and migration.A luciferase reporter assay displayed that mi r-150 also regulated sp1 expression by targeting its 3′-utr, and q rt-pcr and western blotting showed that elevated levels of mi r-150 may reduce sp1 protein expression.The m rna and protein levels of sp1 were upregulated after transfection with a sp1-expression plasmid and partially reversed the inhibitory effects of mi r-150 on cell proliferation, invasion, and metastasis in mg63 and sosp-9607 cells, as well as promoted cell apoptosis.In conclusion, mi r-150 inhibits cell proliferation, invasion, and metastasis and stimulates cell apoptosis by regulating the expression of sp1.Therefore, mi r-150 may be a potential clinical target for the treatment of os patients.

Journal: Cytogenetic and Genome Research (2015)
Publication types: Research Article;
Technology Related to Agricultural Transformation and Development based on 5G Technology

The era of 5g comes quietly, along with the improvement of network operation speed, it also promotes the transformation and development of agriculture, which conforms to the development status of china’s 5g technology and the objective law of agricultural development.Under the guidance of technology and concept, 5g is used to promote agricultural modernization.5g technology will definitely build a new generation of high-speed, instantaneous and secure intelligent information infrastructure in an all-round way, which also means that the information transmission network built by 5g technology will have a comprehensive and profound impact on all aspects of social life.starting from the current agricultural situation, policy support and development prospect, this paper analyzes the factors restricting china’s agricultural development, and puts forward a series of technology-related studies by using the advanced and scientific nature of 5g technology.results indicate that young people use the internet accounted for the biggest is as high as 43.58%, young people can drive in the network platform to promote sales of agricultural products, helping new agricultural development pattern, in order to obtain the professional knowledge of agriculture, 31.47% of farmers are willing to use 5g technology, contribute to the intelligent agricultural technology update and the popularity of e-commerce of agricultural products, it also promoted the agricultural reform and transformation.

Journal: Journal of Physics: Conference Series (2020)
Publication types: Conference Abstract/Paper;
The Integration of Environmental Art Design Based on Artificial Intelligence

In recent years, artificial intelligence has gradually penetrated into people’s lives, and the emerging technological field of "artificial intelligence" has begun to be paid attention by more and more groups.The integration of artificial intelligence in environmental art design has also triggered human exploration of "smart home".The purpose of this article is to promote the development of environmental art design towards intelligentization by discussing the status quo of the development of the intelligent space environment.This article uses the network research method to investigate the intelligent construction of public libraries at and above the provincial level in china.In general, there are 28 libraries with self-service loan and 24-hour self-service library service facilities, and the construction of intelligent projects has reached 93.33%.Intelligentization has become the general trend.analyze the smart home space and environmental art design, promote the development of environmental art design to be intelligent, and provide people with a better quality living environment.

Journal: Journal of Physics: Conference Series (2020)
Publication types: Conference Abstract/Paper;
The Integration of Professional Ethics of Modern Etiquette Students under the Background of Big Data

China is known as the “land of etiquette”.The children of the chinese nation pay attention to etiquette and regard etiquette as an excellent traditional virtue.There are many excellent etiquette models in ancient times.In the current background of diversified development, all kinds of bad ideological trends erode college students, which is not conducive to the development of a harmonious society.College students stepping into the workplace, etiquette training is an important part of employing units to judge their professional qualities.In the current development background of the times, we need to pay more attention to the value of modern etiquette education and quality education of college students in order to improve the professional quality of college students.Therefore, this article starts to study the integration of professional etiquette in modern etiquette under the background of big data.This article combines comparative analysis, experimental methods and questionnaires, and understands the modernity of big data in the context of comparative data and questionnaires.The status of research on professional literacy of university students in etiquette education includes positive aspects and negative aspects.Among them, the positive aspect has a high recognition of etiquette status, accounting for about 65%, the willingness to learn etiquette is about 52%, and the importance of personal instrumentation about 72%, while the negative part includes: lack of etiquette knowledge accounted for 56%, etiquette emotional indifference 31%, etiquette value utility 42%, 67% disconnected etiquette behavior and cognition and public etiquette irregularities accounted for 53%, by analyzing these phenomena and then sorting out the importance of modern etiquette education for college students’professional literacy and the effective integration strategy of modern etiquette education and college student’s professional literacy education, finally, an experimental comparison is made according to the strategies studied in this paper, and the experimental strategies are verified by comparative experiments effectiveness, this article is based on the education of modern etiquette in the context of big data fusion research student professionalism is of great reference value for the cultivation of the college students’ talents.

Journal: Journal of Physics: Conference Series (2020)
Publication types: Conference Abstract/Paper;
MicroRNA-31 weakens cisplatin resistance of medulloblastoma cells via NF-kappa B and PI3K/AKT pathways

Background medulloblastoma (mb) is a malignant intracranial tumor.Cisplatin is a broad‐spectrum antitumor drug.It is important to study the cisplatin resistance of mb cells for the treatment of mb.In this article, we preliminarily studied the cisplatin resistance of micro rna (mi r)‐31 and the possible mechanism in daoy and uw228 cells, laying a theoretical foundation for clinical treatment of mb.Methods following anti‐mi r‐31 and pre‐mi r‐31 transfections, cell viability, brd u, cyclin d1, and apoptosis levels of daoy and uw228 cell were detected by cck8, brd u, and western blot.Meanwhile, migration, invasion, and western blot assay were respectively used to detect the functions of mi r‐31 migration and invasion.Mi r‐31 levels were changed by cell transfection and detected by rt‐q pcr.Furthermore, the related‐proteins of pathways were also detected by western blot.Results anti‐mi r‐31 increased daoy and uw228 cells viability, brd u + numbers, and expression of cyclin d1.The migration/invasion rate and expression levels of mmp‐9 and vimentin after anti‐mi r‐31 transfection were increased.Furthermore, anti‐mi r‐31 enhanced cells' cisplatin resistance and triggered pi3k/akt and nf‐κb pathways.Pre‐mi r‐31 played opposite roles and promoted the apoptosis.Conclusion mi r‐31 regulated cell growth, migration, invasion and cisplatin resistance of mb cells via pi3k/akt and nf‐κb pathways.

Journal: Biofactors (2020)
Publication types: Research Article;
MicroRNA-454 functions as an oncogene by regulating PTEN in uveal melanoma

Micro rnas (mi rnas) regulate gene expression by targeted repression of transcription and translation, and are involved in carcinogenesis.In this study, we demonstrated that the expression of mi r‐454 was up‐regulated in uveal melanoma tissues compared to normal tissues.Ectopic expression of mi r‐454 resulted in significant promotion of cell proliferation, colony formation, invasion and induction of cell cycle in uveal melanoma cells.Furthermore, we identified pten as a direct target of mi r‐454.Our data revealed that ectopic expression of pten restored the effects of mi r‐454 on cell proliferation and invasion in uveal melanoma cells.These findings support an oncogene role of mi r‐454 in development of uveal melanoma.

Journal: FEBS Letters (2015)
Publication types: Research Article;
LncRNA PCGEM1 induces proliferation and migration in non-small cell lung cancer cells through modulating the miR-590-3p/SOX11 axis

Background non-small cell lung cancer (nsclc) is one of the most prevalent cancers.As reported, long non-coding rnas (lnc rnas) induce various biological behaviors in cancers.Lnc rna pcgem1 prostate-specific transcript (pcgem1) is reported to exert carcinogenic effect on certain cancers.Our research aimed to explore the role of pcgem1 in nsclc.Methods we enrolled forty nsclc patients to explore pcgem1 expression in clinical nsclc tissues.Colony formation assay, cck-8, transwell assay were conducted to reveal cell proliferation, viability, migration and invasion.Luciferase reporter assay, rna pull down, and rip assay were performed to investigate the downstream axis of pcgem1.Results pcgem1 was significantly upregulated in nsclc cells and tissues.Subsequently, in vitro loss-of-function experiments illustrated the carcinogenic role of pcgem1 in nsclc through promoting viability, proliferation, migration, and invasion.Mi r-590-3p was confirmed to be a downstream gene of pcgem1.Furthermore, sry-box transcription factor 11 (sox11) was verified to be a target of mi r-590-3p.Additionally, rescue experiments indicated that mi r-590-3p inhibitor or pc dna3.1/sox11 rescued the impacts of downregulated pcgem1 on nsclc cell proliferation, viability, migration and invasion.Conclusions lnc rna pcgem1 aggravated proliferative and migrative abilities in nsclc via the mi r-590-3p/sox11 axis.

Journal: BMC Pulmonary Medicine (2021)
Publication types: Research Article;
MCL1 gene silencing promotes senescence andapoptosis of glioma cells via inhibition of the PI3K/Akt signaling pathway

Glioma is known to be the most prevalent primary brain tumor.In recent years, there has been evidence indicating myeloid cell leukemia‐1 (mcl1) plays a role in brain glioblastoma.Therefore, the present study was conducted with aims of exploring the ability of mcl1 silencing to influence glioma cell senescence and apoptosis through the mediation of the phosphatidylinositol 3‐kinase (pi3k)/protein kinase b (akt) signaling pathway.Glioma and tumor‐adjacent tissues were collected in order to detect the presence of higher levels of mcl1 protein expression.Next, the m rna and protein expression of mcl1, pi3k, akt, b cell lymphoma 2 (bcl2), bcl2‐associated x (bax), b lymphoma mo‐mlv insertion region 1 homolog (bmi‐1), and phosphatase and tensin homolog (pten) were determined.Cell counting kit‐8 assay was applied to detect cell proliferation, β‐galactosidase staining for cell senescence, and flow cytometry for cell cycle entry and apoptosis.Initially, the results revealed higher positive expression rate of mcl1 protein, increased m rna and protein expression of mcl1, pi3k, akt, bmi‐1, and bcl‐2 and decreased that of bax and pten in human glioma tissues.The silencing of mcl1 resulted in a decrease in m rna and protein expression of pi3k, akt, bmi‐1, and bcl‐2 and an increase in bax and pten expressions in glioma cells.Moreover, silencing of mcl1 also inhibited cell proliferation and cell cycle entry in glioma cells, and promoted glioma cell senescence and apoptosis.In conclusion, the aforementioned results collectively suggested that the silencing of mcl1 promotes senescence and apoptosis in glioma cells through inhibiting the pi3k/akt signaling pathway.Thus, decreasing the expression of mcl1 might have therapeutic functions in glioma.© 2018 iubmb life, 71(1):81–92, 2019

Journal: IUBMB Life (2018)
Publication types: Research Article;