syedzayyan/paper_mill_benchmark huggingface dataset:
Clinical Value of Abdominal Ultrasonography in the Diagnosis of Acute Abdomen in Children

In order to study the practical application value of abdominal ultrasonography in the diagnosis and treatment of acute abdomen in children, this study uses the method of collecting clinical actual cases and scientific analysis to estimate the clinical diagnostic value of high‐frequency ultrasound and low‐frequency ultrasound.In order to further clarify its curative effect and treatment advantages, a retrospective analysis of medical records was conducted, and 95 children with acute abdominal pain and suspected appendicitis who were admitted to a hospital from september 2021 to november 2021 were reviewed.Atil hd15000 color doppler ultrasound was used for diagnosis.The results are as follows: the sensitivity, specificity, positive predictive value, and negative predictive value of low‐frequency probe in the diagnosis of intussusception in children were 83.61%, 73.33%, 92.73%, and 52.38%, respectively.The sensitivity, specificity, positive predictive value, and negative predictive value in the diagnosis of mesenteric lymphadenitis were 80.00%, 81.97%, 52.17%, and 94.34%, respectively.The sensitivity, specificity, positive predictive value, and negative predictive value of high‐frequency probe in the diagnosis of intussusception in children were 93.44%, 80.00%, 95.00%, and 75.00%, respectively.The sensitivity, specificity, positive predictive value, and negative predictive value in the diagnosis of mesenteric lymphadenitis were 93.33%, 95.08%, 82.35%, and 98.31%, respectively.Among the children with appendicitis confirmed by operation and pathology, 69 cases were detected by high‐frequency ultrasound and 4 cases were missed (including 3 cases of acute simple appendicitis and 1 case of perforated appendicitis).The false negative was 4%, there was no false positive, and the sensitivity, specificity and accuracy were 95%, 100%, and 96%.In the same cases, 28 cases were detected by low‐frequency ultrasound, 45 cases were missed, the false negative was 61%, and there was no false positive.The sensitivity, specificity, and accuracy were 39%, 100%, and 53%.The sensitivity, accuracy, and false negative of high‐frequency ultrasound in the diagnosis of acute appendicitis were significantly higher than that of low‐frequency ultrasound.This study shows that ultrasound has high accuracy, sensitivity, and specificity in the diagnosis of acute appendicitis.Low‐frequency ultrasound can show the whole picture of the disease and the situation in the abdominal cavity, which can better guide the clinical treatment.Color doppler hemodynamics is a useful supplement to two‐dimensional ultrasound, and ultrasound also plays a positive role in the differential diagnosis of acute appendicitis in children.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Clinical Effects of Primary Nursing on Diabetic Nephropathy Patients Undergoing Hemodialysis and Its Impact on the Inflammatory Responses

To assess the clinical effects of primary nursing on diabetic nephropathy patients undergoing hemodialysis and its impact on inflammatory responses.Methods.Between july 2019 and april 2021, 80 patients with diabetic nephropathy who underwent hemodialysis in our institution were recruited and assigned at a ratio of 1 : 1 to receive either routine nursing (routine group) or primary nursing (primary group).The outcome measures included nursing outcomes, inflammatory factor levels, and psychological status.Results.Primary nursing resulted in lower levels of blood creatinine, fasting glucose, urea nitrogen, and proteinuria versus routine nursing ( p &lt; 0.05 ).Patients receiving primary nursing showed significantly lower levels of interleukin (il)-6, high-sensitivity c-reactive protein (hs-crp), and tumor necrosis factor-alpha (tnf-α) versus those given routine nursing ( p &lt; 0.05 ).The patients in the primary group had significantly lower scores on the self-rating anxiety scale (sas) and self-rating depression scale (sds) versus those in the routine group ( p &lt; 0.05 ).Conclusion.Primary nursing improves the renal function of diabetic nephropathy patients undergoing hemodialysis, reduces the inflammatory response, and eliminates their negative emotions, which shows great potential for clinical application.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Clinical Effect of Mudan Granule on Peripheral Neuritis Caused by Chronic Renal Insufficiency

To investigate the clinical effect of mudan granule on peripheral neuritis caused by chronic renal insufficiency (cri).Methods.Sixty patients with peripheral neuritis caused by cri treated in our hospital were included from february 2018 to april 2021 in this study.The patients were arbitrarily assigned into control group and study group.The former accepted routine treatment, while the latter accepted mudan granule treatment.The clinical efficacy, traditional chinese medicine (tcm) clinical symptom score, nerve conduction velocity, hemorheology index, renal function index, and inflammatory factor index were compared.Results.We firstly compared the clinical efficacy: the study group was clinically cured in 22 cases, obviously effective in 5 cases, effective in 3 cases, and ineffective in 1 case, with a total effective rate of 96.67%.The control group was clinically cured in 9 cases, obviously effective in 8 cases, effective in 7 cases, and ineffective in 6 cases, with a total effective rate of 80.00%.The total effective rate of the study group was higher compared to the control group ( p &lt; 0.05 ).Secondly, we compared the tcm clinical symptom scores; before treatment, there exhibited no significant difference ( p &gt; 0.05 ); after treatment, the tcm clinical symptom scores decreased.The clinical symptom score of tcm in the study group was lower compared to the control group ( p &lt; 0.05 ).Compared with the control group, the nerve conduction velocity of left mcv, right mcv, left scv, and right scv in the study group were remarkably higher.In terms of the hemorheological indexes, the high-shear whole blood viscosity, low-shear whole blood viscosity, and plasma viscosity in the study group were lower compared with the control group ( p &lt; 0.05 ).Before treatment, there existed no significant difference in renal function indexes, but after treatment, the renal function indexes decreased, and the levels of serum creatinine (scr), blood urea nitrogen (bun), and uric acid (ua) in the study group were lower compared to the control group ( p &lt; 0.05 ).Finally, we compared the indexes of inflammatory factors; there existed no significant difference before treatment, but after treatment, the indexes of inflammatory factors decreased in both groups, and the levels of il-6 and crp in the study group were lower compared to the control group ( p &lt; 0.05 ).Conclusion.For peripheral neuritis caused by cri, mudan granule can remarkably promote the clinical symptoms of tcm and reduce the syndrome score of tcm; moreover, it can remarkably increase the nerve conduction velocity of median nerve and common peroneal nerve and reduce blood viscosity, which is worth popularizing and developing in clinic.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Clinical Effect of Metronidazole Vaginal Effervescent Tablet Combined with Flavescentis Sophora Suppository in the Treatment of Trichomonas Vaginitis

For the treatment of trichomonas vaginitis, a combination therapy of metronidazole vaginal effervescent tablet combined with flavescentis sophora suppository is proposed.The patients diagnosed with trichomonas vaginitis are divided into the conventional treatment group and the joint group.The conventional group is treated with metronidazole vaginal effervescent tablets, and the joint group is treated with metronidazole vaginal effervescent tablets combined with sophora bolt.Both groups are treated for 3 months to observe the therapeutic effect of the two treatment methods.The expressions of il‐2 and il‐13 in serum of patients are detected by the elisa.The changes in the vaginal p h value and cleanliness at each time point are observed.The patients are followed up for 6 months after treatment in order to observe the recurrence of trichomonas vaginitis in both groups.Experimental results show that the combination of the two tablets can further improve the clinical efficacy and reduce the inflammatory response and effectively improve the ph value and cleanliness of the vagina, and the recurrence rate is lower, which is worthy of clinical application.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Clinical Study;
CKS2 and S100A12: Two Novel Diagnostic Biomarkers for Rheumatoid Arthritis

Rheumatoid arthritis (ra) is a chronic systematicness autoimmunity disease with joint inflammation.Ra etiology is still unknown.Early and exact diagnosing is still hard to reach.In the paper, we purposed to discover novel diagnosis biological marker for ra.Two open, usable gene expression profiles of human ra as well as controlled specimens (dataset gse17755 as well as gse93272) were downloaded from the geo database.Differentially expressed genes (degs) were screened between 331 ra and 88 control samples.Functional enrichment analysis was applied to explore the possible function of degs.Expression levels as well as diagnosis values of biological marker in ra were further verified in our cohort by the use of rt-pcr and roc assays.We identified 13 degs between ra samples and control samples.13 degs were remarkably abundant in nf-kappa b signal pathway.Among the 13 degs, cks2, s100a12, ly96, and anxa3 exhibited a strong diagnostic ability in screening ra specimens from normal specimens using all auc &gt; 0.8 .Moreover, we confirmed that the expression of cks2 and s100a12 was distinctly upregulated in ra specimens contrasted to normal specimens.Overall, serum cks2 and s100a12 could be used as novel diagnosis biological markers for ra patients.

Journal: Disease Markers (2022)
Publication types: Research Article;
Chlorogenic Acid Prevents Microglia-Induced Neuronal Apoptosis and Oxidative Stress under Hypoxia-Ischemia Environment by Regulating the MIR497HG/miR-29b-3p/SIRT1 Axis

Chlorogenic acid (cga) is a polyphenolic compound with antioxidant and anti-inflammatory properties.Cga has been shown to improve neuroinflammation.This study is aimed at elucidating the exact mechanism by which cga reduces neuroinflammation.Methods.Oxygen and glucose deprivation (ogd) was utilized to treat bv2 microglia and ht-22 hippocampal neurons to engineer an in vitro model of hypoxic ischemia reperfusion.The levels of inflammatory factors (il-1β, il-6, tnf-α, il-4, and il-10) and oxidative stress factors (mda, sod, and gsh-px) in microglia were determined by elisa kits.The neuron proliferation was assessed by cck-8 assay, and ldh kit was used to determine ldh release in neurons.The fluorescent dye dcf-da was employed to measure ros levels in neurons.Correlation of mir497hg, mi r-29b-3p, and sirt1/nf-κb in neurons and microglia was determined by q rt-pcr.Expressions of inflammatory proteins (cox2, i nos), oxidative stress pathways (nrf2, ho-1), and apoptosis-related proteins (bcl-2, bax, caspase3, caspase8, and caspase9) in microglia or neurons were determined by western blot.The interactions between mir497hg and mi r-29b-3p, as well as between mi r-29b-3p and sirt1, were determined by dual luciferase assay and rip assay.Results.Cga attenuated ogd-mediated inflammation and oxidative stress in microglia and inhibited microglia-mediated neuronal apoptosis.Cga increased the levels of mir497hg and sirt1 and suppressed the levels of mi r-29b-3p in bv2 and ht-22 cells.Mir497hg knockdown, mi r-29b-3p upregulation, and sirt1 inhibition inhibited cga-mediated anti-inflammatory and neuronal protective functions.There is a targeting correlation between mir497hg, mi r-29b-3p, and sirt1.Mir497hg sponges mi r-29b-3p to regulate sirt1 expression in an indirect manner.Conclusion.Cga upregulates mir497hg to curb mi r-29b-3p expression, hence initiating the sirt1/nf-κb signaling pathway and repressing ogd-elicited inflammation, oxidative stress, and neuron apoptosis.

Journal: Disease Markers (2022)
Publication types: Research Article;
Changes of Entropy Index and Cerebral Oxygen Metabolism in the Maintenance of Remifentanil Anesthesia and Their Predictive Value for Postoperative Hyperalgesia

To explore the changes of entropy index and cerebral oxygen metabolism in the maintenance of remifentanil anesthesia and the predictive value of postoperative hyperalgesia.Methods.A total of 266 patients undergoing general anesthesia in our hospital from january 2020 to october 2021 were selected, and remifentanil was used to maintain anesthesia.The state entropy, reaction entropy, and cerebral oxygen metabolism indexes (cerebral oxygen uptake rate (cero2), arterial-venous blood oxygen difference (da-jv o2)) of patients before induction of anesthesia, 15 minutes during the operation, and at the end of the operation were compared.The influencing factors of postoperative hyperalgesia were analyzed.The logistic regression model of postoperative hyperalgesia was established, and the value of entropy index and cerebral oxygen metabolism in predicting postoperative hyperalgesia was evaluated by drawing the receiver operating characteristic curve (roc).Results.The state entropy, response entropy, and cero2 at 30 min during the operation and at the end of the operation were lower than those before the induction of anesthesia, and da-jv o2 was higher than that before the induction of anesthesia ( p &lt; 0.001 ).At the end of the operation, the state entropy, reaction entropy, and cero2 were higher than 30 minutes during the operation, and da-jv o2 was lower than 30 minutes during the operation ( p &lt; 0.001 ).The dosage of remifentanil, reaction entropy, and cero2 at the end of the operation entered the logistic model.The auc value of the reaction entropy and cero2 combined to predict postoperative hyperalgesia at the end of the operation was 0.851 greater than the reaction entropy at the end of the operation ( χ 2 = 3.847 , p = 0.036 ), cero2 ( χ 2 = 2.589 , p = 0.010 ) single index predictive value.Conclusion.The entropy index and cerebral oxygen metabolism in general anesthesia patients change with the progress and discontinuation of remifentanil maintenance anesthesia, and the combination of the two has a high predictive power in postoperative hyperalgesia risk assessment.When the reaction entropy &gt; 54.23 , cer o 2 &gt; 34.14 % , or the total dosage of remifentanil ≥ 30 μ g / kg at the end of the operation, we should be highly vigilant of the occurrence of postoperative hyperalgesia and postoperative analgesia management should be strengthened.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Assessment of Clinical Diagnostic Efficacy of Pulmonary Function Test Based on DBN-SVM of Pediatric Asthma and Cough Variant Asthma

The diagnosis of asthma depends on the unprejudiced proof of the varying airflow obstruction.The pulmonary function tests are carried out to evaluate the clinical value of different types of respiratory diseases in children or infants.This study is focused on the clinical evaluation of the pulmonary function tests in the diagnosis of pediatric asthma and cough variant asthma.A differential diagnosis method for chronic obstructive pulmonary disease (copd) and asthma-copd overlap with complementary diagnostic value is proposed.For the pulmonary function tests, the copd gene dataset was selected and feature selection was performed using the dbn-svm scoring method.For analysis and comparison, the differential diagnosis models were built using roc curves for the accuracy of the deep belief network model and the support vector machine model.The sensitive features associated with copd and aco classification using the deep belief network model were found to be in good agreement with known clinical diagnostic strategies.The clinical diagnosis tests for pulmonary pediatric asthma and cough variant asthma were conducted on two groups of children, with both groups containing a basis of comparison.80 cases of pediatric asthma and cough variant asthma were admitted from 2013 to 2014 and 80 cases of children with a healthy physical examination.The results of the two groups were compared.The results showed that the levels of fev1, pef, and fvc were significantly lower ( p &lt; 0.05 ), in healthy children, and fev1/fvc%, rv, and rv/tcl% were significantly higher ( p &lt; 0.05 ) in children with asthma and cough variant asthma during acute exacerbation and chronic persistence.There were no statistically significant differences in the duration of clinical remission ( p &gt; 0.05 ).Thus, the study suggests that confirmed cases of the diagnosis of pediatric asthma and cough variant asthma by pulmonary function tests were significantly higher than those of conventional tests ( p &lt; 0.05 ).From this study, we can conclude that pulmonary function tests can accurately diagnose pediatric asthma and cough variant asthma, and also accurately reflect the development of the child’s disease, which is of high clinical value.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Application Value Analysis of Nanooptical Materials in Martial Art Single-Kick Protective Equipment

If there is no protective equipment in martial art single practice, it is very easy to be injured, so protective equipment in martial arts has been paid more and more attention.The protective effect of wushu sanda protective gear is related to the safety of every wushu sanda practitioner.The purpose of this paper is to study crystalline nanooptical materials and wushu sanda protective gear and propose the idea of using more crystalline nanooptical materials in the manufacture and use of wushu sanda protective gear.This paper mainly introduces the related content of crystalline nanooptical materials, martial art single‐leg kick, and martial art single‐leg protective gear and conducts experiments on crystalline nanooptical materials and martial art single‐leg protective gear based on crystalline nanooptical materials.The experimental results show that the protective effect of protective equipment based on crystalline nanooptical materials can play a greater role than traditional protective equipment.In the experiments in this paper, the martial art single‐leg kicking protective gear based on crystalline nanooptical materials has at least a 10% improvement in protective effect.

Journal: Journal of Nanomaterials (2022)
Publication types: Research Article;
Application of BIM Technology in Data Collection of Large-Scale Engineering Intelligent Construction

In order to solve the problem of data collection of intelligent construction of large-scale projects, the author proposes the application of bim technology in the collection of intelligent construction data of large-scale projects; this method proposes to take advantage of the technical advantages of bim; starting from the needs of the commercial complex operation and management stage, a bim-based commercial complex operation management model is established, and the application content of this model to improve the efficiency of commercial complex operation and management is studied.The experimental results show that according to the design conditions and the depth of bim application, the standard elements and variable factors can be divided into 70% and 30%, respectively.Conclusion.Bim can realize the refinement, intelligence, and quality of commercial complex operation.

Journal: Wireless Communications and Mobile Computing (2022)
Publication types: Research Article;
Application Effect Analysis of a Nanotube Combined with Orthopedic Exercise Rehabilitation Therapy in the Treatment of Patients with Knee Arthritis

Knee arthritis is one of the common diseases with the highest incidence in osteoarthrosis, which seriously affects people’s health, and as the patient’s medical history prolongs, the pain degree becomes more and more serious.In recent years, with the rapid development of nanotechnology, its application scope has gradually been involved the medical field.The application of nanotube‐targeted drugs to treat osteoarthritis can repair bone to a certain extent and relieve patient pain symptom.Sports rehabilitation therapy, as an important nursing method in orthopedic treatment, can improve the patient’s body recovery ability and enhance the therapeutic effect of surgery.Based on this, this article proposes the application research of a nanotube combined with exercise rehabilitation therapy in the treatment of patients with knee arthritis.The research carried out in this article is mainly divided into three parts: the first part is the research of titanium dioxide nanotubes in orthopedic treatment, studying the diameter and drug loading of nanotubes, research on how to target the damaged bone tissue and release drugs, and discussing the tissue compatibility and safety of nanotubes to the human body; the second part is the study on exercise rehabilitation therapy in orthopedic treatment and study on how to exercise properly to enhance the patient’s body recovery; the third part is clinical investigation and research, according to the observation group in contrast with the indicators of the control group to draw conclusions.The results of this experiment show that in the clinical treatment of knee arthritis surgery, in the analysis of postoperative patients, the scores of the three groups of patients before treatment were relatively low, with scores ranging from 5 to 8, but the scores of the observation group were significantly higher than those of the first and second groups.The observation group ranged from 7 to 10.The joint scores of the observation group gradually increased at 1 week and 2 weeks after treatment.The increase in functional score was more pronounced.For patients with a longer medical history, perform appropriate helping exercises.Titanium dioxide nanotubes have good antibacterial properties as an endoplant and good histocompatibility with human bones.In the observation group combined with exercise therapy, various complications such as pain, swelling, and muscle atrophy were relatively small, allowing the patient to speed up the recovery of various body functions.

Journal: Journal of Nanomaterials (2022)
Publication types: Research Article;