syedzayyan/paper_mill_benchmark huggingface dataset:
National application of the European visual field standards for driving: a survey study.

S to provide an overview of how the european visual field standards for driving (specified in commission directive 2009/113/ec) are applied and determine whether individuals with visual field defects are treated equally across europe.Methods one ophthalmic expert from each of 32 european countries was invited to participate in an electronic survey.They were presented with threshold and esterman perimetry results of 15 cases of visual field defects and asked to classify each case as either passed or failed in reference to their national standards.The results were compared with the european driving test group 1 (edt1), which is a new perimetry algorithm that adheres to the recommendations by the eyesight working group.Fleiss' kappa was used to determine the inter-rater agreement.Results twenty-five countries responded.Three of 15 cases were passed by all.Full agreement on a failed case was not reached.Denmark graded most leniently and passed 12 cases.Bulgaria, romania and slovakia graded most strictly and passed five cases.The fleiss' kappa score was 0.52 (95% ci 0.49 to 0.55).Only slovenia was in full agreement with the edt1.Fifteen countries endorsed specific perimetric tests for assessing fitness to drive.Five of these also defined pass/fail criteria.Conclusion the directive fails to establish a uniform approach to the visual field requirements, as evident by moderate pass/fail agreement between the national experts.Because the visual standards for driving are enforced differently, identical visual field loss can result in either revocation or approval of a driving license.

Journal: BMJ open ophthalmology (2022)
Publication types: Journal Article
Mechanical thrombectomy combined with stenting for radiation-induced carotid stenosis-related stroke with high-load embolization: A case report.

Radiation therapy in patients with nasopharyngeal carcinoma can cause chronic progressive carotid artery injury, but acute ischemic stroke caused by carotid artery high-load thrombosis rarely occurs in patients with tandem lesions.We performed carotid mechanical thrombectomy combined with angioplasty in a 57-year-old man who received radiotherapy for nasopharyngeal carcinoma more than 10 years before presentation.He presented with acute-onset left hemiplegia, confusion, and mixed aphasia.Head ct revealed a hyper-dense sign in the right middle cerebral artery m1 region, and angiography disclosed occlusion in the right internal carotid artery c5 region with extremely severe stenosis in the middle c1 region.Intra-arterial mechanical thrombectomy with carotid stenting was performed, and re-canalization was achieved.Re-examination angiography after 3 months revealed worsening of ulcerative plaques and pseudoaneurysms in the left common carotid artery.Consequently, we performed carotid stenting over the left common carotid artery, and the patient recovered well postoperatively.Our experience suggests that early detection of large blood vessel damage and intervention are necessary to prevent large-vessel ischemic stroke in patients who received radiotherapy for nasopharyngeal carcinoma.

Journal: Radiology case reports (2022)
Publication types: Case Reports;Journal Article
Metabolomics and network pharmacological analysis to explore the mechanism of ginseng treatment for spleen-qi deficiency.

Ginseng is the main chinese herbal medicine for tonifying qi and invigorating the spleen.It has been used to treat spleen-qi deficiency with good protective effects for thousands of years, however, its biological mechanism has not been fully elucidated.This study aims to explore the mechanism of ginseng in the treatment of spleen-qi deficiency by using a comprehensive method combining metabolomics and network pharmacological analysis.Gas chromatography-mass spectroscopy was applied for investigating the changes in urine metabolites in spleen-qi deficiency rats and after treatment with ginseng.Metabolomics and network pharmacology analysis were applied to screen potential biomarkers and therapeutic targets of ginseng in the treatment of spleen-qi deficiency, respectively.Molecular docking was employed to further evaluate the docking mode of potential biomarkers and therapeutic target proteins.The results of metabolomics showed that the therapeutic effects of ginseng are mainly related to its regulation of three metabolic pathways.The molecular structure of potential biomarkers and common proteins was further analyzed by molecular docking to verify its effectiveness.Ginseng has good pharmacological effects by controlling key targets of related metabolic pathways, signal pathways, and potential biomarkers.

Journal: Journal of separation science (2022)
Publication types: Journal Article
Effect of High-Flow Nasal Cannula Oxygen vs Standard Oxygen Therapy on Mortality in Patients With Respiratory Failure Due to COVID-19: The SOHO-COVID Randomized Clinical Trial.

Importance the benefit of high-flow nasal cannula oxygen (high-flow oxygen) in terms of intubation and mortality in patients with respiratory failure due to covid-19 is controversial.Objective to determine whether the use of high-flow oxygen, compared with standard oxygen, could reduce the rate of mortality at day 28 in patients with respiratory failure due to covid-19 admitted in intensive care units (icus).Design, setting, and participants the soho-covid randomized clinical trial was conducted in 34 icus in france and included 711 patients with respiratory failure due to covid-19 and a ratio of partial pressure of arterial oxygen to fraction of inspired oxygen equal to or below 200 mm hg.It was an ancillary trial of the ongoing original soho randomized clinical trial, which was designed to include patients with acute hypoxemic respiratory failure from all causes.Patients were enrolled from january to december 2021; final follow-up occurred on march 5, 2022.Interventions patients were randomly assigned to receive high-flow oxygen (n = 357) or standard oxygen delivered through a nonrebreathing mask initially set at a 10-l/min minimum (n = 354).Main outcomes and measures the primary outcome was mortality at day 28.There were 13 secondary outcomes, including the proportion of patients requiring intubation, number of ventilator-free days at day 28, mortality at day 90, mortality and length of stay in the icu, and adverse events.Results among the 782 randomized patients, 711 patients with respiratory failure due to covid-19 were included in the analysis (mean [sd] age, 61 [12] years; 214 women [30%]).The mortality rate at day 28 was 10% (36/357) with high-flow oxygen and 11% (40/354) with standard oxygen (absolute difference, -1.2% [95% ci, -5.8% to 3.4%]; p = .60).Of 13 prespecified secondary outcomes, 12 showed no significant difference including in length of stay and mortality in the icu and in mortality up until day 90.The intubation rate was significantly lower with high-flow oxygen than with standard oxygen (45% [160/357] vs 53% [186/354]; absolute difference, -7.7% [95% ci, -14.9% to -0.4%]; p = .04).The number of ventilator-free days at day 28 was not significantly different between groups (median, 28 [iqr, 11-28] vs 23 [iqr, 10-28] days; absolute difference, 0.5 days [95% ci, -7.7 to 9.1]; p = .07).The most common adverse events were ventilator-associated pneumonia, occurring in 58% (93/160) in the high-flow oxygen group and 53% (99/186) in the standard oxygen group.Conclusions and relevance among patients with respiratory failure due to covid-19, high-flow nasal cannula oxygen, compared with standard oxygen therapy, did not significantly reduce 28-day mortality.Trial registration clinical trials.gov identifier: nct04468126.

Journal: JAMA (2022)
Publication types: Comparative Study;Journal Article;Multicenter Study;Randomized Controlled Trial
Integration of Cancer Genomics Data for Tree-based Dimensionality Reduction and Cancer Outcome Prediction.

Accurate outcome prediction is crucial for precision medicine and personalized treatment of cancer.Researchers have found that multi-dimensional cancer omics studies outperform each data type (m rna, micro rna, methylation or somatic copy number alteration) study in human disease research.Existing methods leveraging multiple level of molecular data often suffer from various limitations, e.G., heterogeneity, poor robustness or loss of generality.To overcome these limitations, we presented the tree-based dimensionality reduction approach for the identification of smooth tree graph and developed accurate predictive model for clinical outcome prediction.We demonstrated that 1) discriminative dimensionality reduction via learning a tree (ddrtree) achieved reduced dimension space tree with statistical significance; 2) tree based support vector machine (svm) classifier improved prediction performance of cancer recurrence as compared to t-test based svm classifier; 3) tree based svm classifier was robust with regard to the different number of multi-markers; 4) combining multiple omics data improved prediction performance of cancer recurrence as compared to a single-omics data; and 5) tree based svm classifier achieved similar or better prediction performance when compared to the features from state-of-the-art feature selection methods.Our results demonstrated great potential of the tree-based dimensionality reduction approach based clinical outcome prediction.

Journal: Molecular informatics (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Effects of olfactory training on posttraumatic olfactory dysfunction: a systematic review and meta-analysis.

Posttraumatic olfactory dysfunction is a clinical challenge due to refractory characteristics and limited therapeutic options.Olfactory training has been proved to be effective for olfactory dysfunction with varied etiologies.We pooled existing studies to evaluate the effects of olfactory training in patients with posttraumatic olfactory dysfunction.Methods a systematic literature review using pub med, embase, cochrane library, and web of science was conducted to identify studies assessing olfactory change in patients with posttraumatic olfactory dysfunction after olfactory training.Results of the initial 812 abstracts reviewed, 13 full-text articles were included.Clinically significant results after olfactory training were defined as an improvement of threshold, discrimination, and identification (tdi) score ≥6 or university of pennsylvania smell identification test (upsit) score ≥4.Six studies were included in the meta-analysis, 36.31% (95% confidence interval [ci], 0.28 to 0.45) of posttraumatic patients would achieve clinically significant results after olfactory training with a mean increase of tdi score of 4.61.Conclusion olfactory training might be a promising modality for the treatment of posttraumatic olfactory dysfunction.More high-quality studies with controls are needed to clarify the effect of olfactory training on total olfactory performance and subcomponents of olfaction.

Journal: International forum of allergy & rhinology (2021)
Publication types: Journal Article;Meta-Analysis;Review;Systematic Review
Comparison of outcome between small incision lenticule extraction and FS-LASIK in eyes having refractive error greater than negative 10 diopters.

To compare small incision lenticule extraction (smile) and femtosecond laser-assisted laser in situ keratomileusis (fs-lasik) in terms of safety, refractive outcomes, visual quality, and biomechanical responses in correcting myopia with maximum myopic meridian exceeding 10 diopters (d).Setting zhongshan ophthalmic center, sun yat-sen university.Design prospective, randomized, comparative study.Methods the study comprised 60 eyes (60 patients) with a maximum myopic meridian exceeding 10 d; 30 eyes were corrected using smile and 30 eyes were corrected using fs-lasik.Patients received preoperative and 6-month postoperative examinations, including refractive outcomes, corneal curve, contrast sensitivity, ocular aberrometry, and corneal biomechanical responses.Results at 6 months postoperatively, the uncorrected distance visual acuity was -0.01 ± 0.06 and -0.05 ± 0.10 in the smile and lasik eyes, respectively (p = .08).The corrected distance visual acuity was -0.07 ± 0.07 and -0.08 ± 0.08 (p = .624), respectively.The postoperative spherical equivalent (se) was -0.20 ± 0.25 d and -0.03 ± 0.20 d, respectively (p = .008).The posterior corneal curvature was unchanged after smile and fs-lasik (p > .05).The measured corneal thickness was reduced by 137.40 ± 15.01 μm and 155.06 ± 17.43 μm (p < .001).The change in the se was -0.01 ± 0.26 and -0.13 ± 0.30 from 1 week (p = .103).Only the peak distance (the distance between the highest points of the nondeformed corneal parts) differed between the groups (1.06 ± 1.44 mm vs -0.26 ± 1.16 mm, p = .007).In the smile patients, changes in higher-order aberration (p = .018) and spherical aberration (p = .011) were smaller than in lasik patients.Conclusions compared with lasik, smile might offer superior safety and objective visual quality, comparable stability and efficacy, and a little inferior predictability in correcting maximum myopic meridian exceeding 10 d.

Journal: Journal of cataract and refractive surgery (2020)
Publication types: Comparative Study;Journal Article;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
Intraoperative Radiofrequency Ablation for Contralateral Benign Nodules in Unilateral Thyroid Cancer Patients to Relieve Anxiety.

Introduction for unilateral papillary thyroid carcinoma (ptc) with contralateral benign nodules, optimal extent of surgery remains controversial.This retrospective cohort study was performed to evaluate the life quality of patients who underwent lobectomy alone and lobectomy with radiofrequency ablation (rfa).Methods from october 2014 to october 2018, unilateral ptc patients with contralateral benign nodules reported by fine-needle aspiration cytology who encountered anxiety about contralateral nodule progression underwent lobectomy for ptc and intraoperative rfa for contralateral nodules.The patients who underwent thyroid lobectomy were matched for sex, age at time of surgery, number, size, and location of primary tumors and contralateral nodules to the patients who underwent lobectomy with intraoperative rfa.Three questionnaires were used to evaluate life quality in the two groups.The complications and rate of patients who were not required to receive thyroid-stimulating hormone suppression therapy were recorded.Results one hundred forty-eight patients with 194 contralateral nodules underwent rfa in the lobectomy plus rfa group, and age- and sex-matched patients underwent thyroid lobectomy alone.The mean volume reduction ratio was 67.7% at 12 mo and 95.2% at 24 mo.After a median follow-up of 4.2 y, nine patients (6.1%) in the lobectomy plus rfa group and 17 (11.5%) in the thyroid lobectomy-alone group underwent completion thyroidectomy (p = 0.100).Patients who underwent lobectomy plus rfa had a better quality of life in terms of anxiety, physiological health, social and family aspects, and psychological and sensory features that were measured cross-sectionally at 6 mo using three instruments.Conclusions intraoperative rfa is effective in terms of volume reduction of contralateral nodules and improved quality of life for unilateral ptc patients with anxiety about disease progression.

Journal: The Journal of surgical research (2022)
Publication types: Journal Article
Calcium-vesicles perform active diffusion in the sea urchin embryo during larval biomineralization.

Biomineralization is the process by which organisms use minerals to harden their tissues and provide them with physical support.Biomineralizing cells concentrate the mineral in vesicles that they secret into a dedicated compartment where crystallization occurs.The dynamics of vesicle motion and the molecular mechanisms that control it, are not well understood.Sea urchin larval skeletogenesis provides an excellent platform for investigating the kinetics of mineral-bearing vesicles.Here we used lattice light-sheet microscopy to study the three-dimensional (3d) dynamics of calcium-bearing vesicles in the cells of normal sea urchin embryos and of embryos where skeletogenesis is blocked through the inhibition of vascular endothelial growth factor receptor (vegfr).We developed computational tools for displaying 3d-volumetric movies and for automatically quantifying vesicle dynamics.Our findings imply that calcium vesicles perform an active diffusion motion in both, calcifying (skeletogenic) and non-calcifying (ectodermal) cells of the embryo.The diffusion coefficient and vesicle speed are larger in the mesenchymal skeletogenic cells compared to the epithelial ectodermal cells.These differences are possibly due to the distinct mechanical properties of the two tissues, demonstrated by the enhanced f-actin accumulation and myosin ii activity in the ectodermal cells compared to the skeletogenic cells.Vesicle motion is not directed toward the biomineralization compartment, but the vesicles slow down when they approach it, and probably bind for mineral deposition.Vegfr inhibition leads to an increase of vesicle volume but hardly changes vesicle kinetics and doesn't affect f-actin accumulation and myosin ii activity.Thus, calcium vesicles perform an active diffusion motion in the cells of the sea urchin embryo, with diffusion length and speed that inversely correlate with the strength of the actomyosin network.Overall, our studies provide an unprecedented view of calcium vesicle 3d-dynamics and point toward cytoskeleton remodeling as an important effector of the motion of mineral-bearing vesicles.

Journal: PLoS computational biology (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Plantar sensation, plantar pressure, and postural stability alterations and effects of visual status in older adults.

Ageing leads to plantar sensation and pressure alterations and poor postural control.The aim of this study was to compare the plantar sensation and static plantar pressure distribution between young and older adults.A secondary aim was to investigate the effect of ageing and visual status on postural stability.Materials and methods forty older subjects and 43 young adult individuals participated in the study.Plantar light touch sensation was evaluated using semmes-weinstein monofilaments.Static plantar pressure and postural stability were assessed with the win track®pedobarography device.Results plantar sensation thresholds of the older individuals were higher compared to the young in all plantar regions (p< 0.001).The plantar contact area was greater in older individuals (p< 0.001).Maximum plantar pressure of midfoot was higher and maximum plantar pressure of the rearfoot and whole foot was less in older individuals during quiet stance (p< 0.05).The main effects of group and visual condition were significant for mean latero-lateral and antero-posterior sway speed with large effect sizes (p< 0.05).Conclusions the sensation of all plantar regions reduced, the rearfoot plantar pressure decreased, and the midfoot plantar pressure increased in older individuals compared to young.Postural stability was reduced in the older individuals, and their postural control was more affected by the eliminated visual information compared to the young.Increased plantar contact area and midfoot plantar pressure may be related to decreased mla height in older individuals.Older individuals may need visual information more to maintain postural control because of reduced plantar sensation.

Journal: Somatosensory & motor research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Flexible Pressure Sensor Array with Multi-Channel Wireless Readout Chip.

Flexible sensor arrays are widely used for wearable physiological signal recording applications.A high density sensor array requires the signal readout to be compatible with multiple channels.This paper presents a highly-integrated remote health monitoring system integrating a flexible pressure sensor array with a multi-channel wireless readout chip.The custom-designed chip features 64 voltage readout channels, a power management unit, and a wireless transceiver.The whole chip fabricated in a 65 nm complementary metal-oxide-semiconductor (cmos) process occupies 3.7 × 3.7 mm2, and the core blocks consume 2.3 m w from a 1 v supply in the wireless recording mode.The proposed multi-channel system is validated by measuring the ballistocardiogram (bcg) and pulse wave, which paves the way for future portable remote human physiological signals monitoring devices.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article
Metabolite Comparison between Serum and Follicular Fluid of Dairy Cows with Inactive Ovaries Postpartum.

Inactive ovaries (io) accounts for 50% of ovarian disease in postpartum dairy cows, which seriously affects their reproductive efficiency.To investigate the metabolic changes in the serum and follicular fluid of dairy cows with io during lactation, six estrus (e) cows and six io cows at 50 to 55 days in milk were selected based on b ultrasonic detection and clinical manifestations.The differential metabolites in serum and follicular fluid between the e cows and io cows were identified by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry, combined with multidimensional statistical methods.The results showed that dairy cows with io were in a subclinical ketosis status where beta-hydroxybutyrate (bhb) exceeded 1.20 mmol/l, 14 differential metabolites in the serum of io cows included 10 increased metabolites and 4 decreased metabolites, and 14 differential metabolites in the follicular fluid of io cows included 8 increased metabolites and 6 decreased metabolites.These differential metabolites mainly involved nine metabolic pathways.The common enrichment pathway of different metabolites in serum and follicular fluid were glycerophospholipid metabolism and pentose and glucuronate interconversions.In conclusion, there were significant differences in the differential metabolites and enrichment pathways between serum and follicular fluid of io cows, implying that there were complex changes in blood metabolism and local follicular metabolism of io cows, whose interactions need further investigation.

Journal: Animals : an open access journal from MDPI (2022)
Publication types: Journal Article
Related factors of outcomes of pharyngeal foreign bodies in children.

This study aimed to identify factors related to outcomes of the pharyngeal foreign bodies in children and to improve the management protocol of this disease.Methods the medical records of 131 children with pharyngeal foreign bodies hospitalized in the hospital were retrospectively reviewed.Results significant differences were observed between the two groups (dislodgement and removal group) with respect to location of pharyngeal foreign bodies and age, while sex, time of pharyngeal foreign bodies, and nature of pharyngeal foreign bodies had no significant differences.Moreover, results suggested that location of pharyngeal foreign bodies and nature of pharyngeal foreign bodies were risk factors correlated with complications.Conclusion pharyngeal foreign body in children has a high rate of dislodgement (>50%).Foreign bodies in the oropharynx were more likely to dislodge compared with the foreign bodies in the laryngopharynx.Younger children were more likely to dislodge compared with older children.Although the risk of complications was very low, attention needs to be paid to the potential risks: local infection, deep abscess, and migration of foreign bodies.Because the possibility of complications caused by bone fragments and foreign bodies in the laryngopharynx increase obviously, hence, it is suggested to remove these kinds of foreign bodies as soon as possible to prevent complications.

Journal: SAGE open medicine (2017)
Publication types: Journal Article