syedzayyan/paper_mill_benchmark huggingface dataset:
Model Construction of Hierarchical Polarization Characteristics Combined with Social E-Commerce Consumer Behavior

In order to analyze the consumer behavior of social e-commerce, this article attempts to explore the irrational consumer behavior factors that affect the audience in the live broadcast of e-commerce internet celebrities.This paper predicts and analyzes the consumption behavior of social e-commerce and combines the characteristics of hierarchical planning to intelligently process the system to improve the effectiveness of the system.Moreover, this paper constructs a social e-commerce consumer behavior prediction model based on hierarchical polarization characteristics, researches and analyzes multiple factors and performance, and builds an intelligent simulation model.The analysis of the test results shows that the social e-commerce consumer behavior prediction model based on the hierarchical polarization characteristics proposed in this article is effective and can play an important role in the prediction of social consumer behavior.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Intermittent Hypoxia and Atherosclerosis: From Molecular Mechanisms to the Therapeutic Treatment

Intermittent hypoxia (ih) has a dual nature.On the one hand, chronic ih (cih) is an important pathologic feature of obstructive sleep apnea (osa) syndrome (osas), and many studies have confirmed that osa-related cih (osa-cih) has atherogenic effects involving complex and interacting mechanisms.Limited preventive and treatment methods are currently available for this condition.On the other hand, non-osa-related ih has beneficial or detrimental effects on the body, depending on the degree, duration, and cyclic cycle of hypoxia.It includes two main states: intermittent hypoxia in a simulated plateau environment and intermittent hypoxia in a normobaric environment.In this paper, we compare the two types of ih and summarizes the pathologic mechanisms and research advances in the treatment of osa-cih-induced atherosclerosis (as), to provide evidence for the systematic prevention and treatment of osas-related as.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Mitochondrial Dysfunction and Cardiovascular Disease: Pathophysiology and Emerging Therapies

Mitochondria ensure the supply of cellular energy through the production of atp via oxidative phosphorylation.The alteration of this process, called mitochondrial dysfunction, leads to a reduction in atp and an increase in the production of reactive oxygen species (ros).Mitochondrial dysfunction can be caused by mitochondrial/nuclear dna mutations, or it can be secondary to pathological conditions such as cardiovascular disease, aging, and environmental stress.The use of therapies aimed at the prevention/correction of mitochondrial dysfunction, in the context of the specific treatment of cardiovascular diseases, is a topic of growing interest.In this context, the data are conflicting since preclinical studies are numerous, but there are no large randomized studies.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Metaheuristic Optimization-Driven Novel Deep Learning Approach for Brain Tumor Segmentation

Brain tumor has the foremost distinguished etiology of high morality.Neoplasm, a categorization of brain tumors, is very operative in distinguishing and determining the tumor’s exact location in the brain.Magnetic resonance imaging (mri) is an efficient noninvasive technique for the anatomical examination of brain tumors.Growth tissues have a distinguishable look in mri pictures in order that they are unit‐wide used for brain tumor feature extraction.The existing research algorithms for brain tumors have some limitations such as different qualities, low sensitivity, and diagnosing the tumor at its stages.In this particular piece of research, an innovative method of optimization known as the procedure for lightning attachment algorithm (pla) is used, and for the purpose of classification, a cnn model known as dense net‐169 is applied.Pla was used in order to optimize the growth, and a network model known as the dense net‐169 model was utilized in order to extract the various growth‐optimization choices.First, the mr images of the brain were preprocessed to remove any outliers.Next, the dense net‐169 cnn model was used to extract network choices from the mr images.In addition, it is used to execute the function of a classifier in order to identify the growth as either an aberrant growth or a traditional growth.In addition, the publicly benchmarked datasets that are widely utilized have validated the algorithmic rule that was granted.The planned system demonstrates the satisfactory accuracy in getting ready to on the dataset and outperforms many of the notable current techniques.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Lung Cancer Classification and Prediction Using Machine Learning and Image Processing

Lung cancer is a potentially lethal illness.Cancer detection continues to be a challenge for medical professionals.The true cause of cancer and its complete treatment have still not been discovered.Cancer that is caught early enough can be treated.Image processing methods such as noise reduction, feature extraction, identification of damaged regions, and maybe a comparison with data on the medical history of lung cancer are used to locate portions of the lung that have been impacted by cancer.This research shows an accurate classification and prediction of lung cancer using technology that is enabled by machine learning and image processing.To begin, photos need to be gathered.In the experimental investigation, 83 ct scans from 70 distinct patients were utilized as the dataset.The geometric mean filter is used during picture preprocessing.As a consequence, image quality is enhanced.The k ‐means technique is then used to segment the images.The part of the image may be found using this segmentation.Then, classification methods using machine learning are used.For the classification, ann, knn, and rf are some of the machine learning techniques that were used.It is found that the ann model is producing more accurate results for predicting lung cancer.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Glutathione, Cysteine, and D-Penicillamine Role in Exchange of Silver Metal from the Albumin Metal Complex

The purpose of this study is to investigate the exchange reaction taking place among the bovine serum albumin (bsa), 5,5′‐dithiobis‐(2‐nitrobenzoic acid (esse), reduced glutathione, n‐acetylcysteine, d‐penicillamine (thiolates), and silver metal (ag i ).For this purpose, stock solutions of bsa and ellman’s reagent were prepared by dissolving 264 mg of bsa in 5 ml of reaction buffer (0.1 m kh 2 po 4 at p h 7.8) and 23.8 mg of esse in 1.0 ml of reaction buffer which were mixed together.Mixture of bsa‐ag i was prepared in a separate procedure by dissolving 0.17 mg of silver nitrate in 1 ml of reaction buffer and then dissolving bsa (200 mg) in the same solution of silver nitrate.Blocking of cys‐34 of bsa with ag i was confirmed by treating different dilutions of bsa‐ag i (500 μ m) solutions with the solutions of esse (85 μ m) and es - (85 μ m) and recording the spectra (300‐450) with a uv‐visible spectrophotometer.The chromatographed ag i ‐modified bsa ((bsa‐s)ag i )) samples (typically 500 μ m) were subsequently mixed with thiolates (reduced glutathione, n‐acetylcysteine, and d‐penicillamine).Ag i and modified bsa (typically 500 μ m each) were treated with these low molecular weight thiolates and allowed to react overnight followed by chromatographic separation (sephadex g25).The redox reactions of ag i ‐modified bsa with various low molecular weight thiols revealed a mechanically important phenomenon.In the case of reduced glutathione and n‐acetylcysteine, we observed the rapid release of a commensurate amount of ellman’s anion, indicating that an exchange has taken place and low molecular weight thiols (rsh) substituted ag i species at the cys‐34 of bsa eventually forming disulfide (bsa‐ssr) at cys‐34.It can be anticipated from the phase of study involving bovine serum albumin that low molecular weight thiolates (reduced glutathione and n‐acetylcysteine) take off ag i which are attached to proteins elsewhere in the physiological system, making these toxic metals free for toxic action.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Ginsenoside Rg1 Ameliorates Acute Renal Ischemia/Reperfusion Injury via Upregulating AMPKα1 Expression

Acute renal ischemia/reperfusion (i/r) injury often occurs during kidney transplantation and other kidney surgeries, and the molecular mechanism involves oxidative stress.We hypothesized that ginsenoside rg1 (rg1), a saponin derived from ginseng, would protect the renal tissue against acute renal i/r injury by upregulating 5 ′ adenosine monophosphate-activated protein kinase α1 (ampkα1) expression and inhibiting oxidative stress.The models of acute anoxia/reoxygenation (a/r) damage in normal rat kidney epithelial cell lines (nrk-52e) and acute renal i/r injury in mice were constructed.The results revealed that pretreatment with 25 μm rg1 significantly increased nrk-52e viability, decreased lactate dehydrogenase (ldh) activity and apoptosis, suppressed reactive oxygen species generation and oxidative stress, stabilized mitochondrial membrane potential and reduced mitochondria permeability transition pore openness, decreased adenosine monophosphate/adenosine triphosphate ratio, and upregulated the expression of ampkα1, cytochrome b-c1 complex subunit 2, nadh dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8, and b-cell lymphoma 2, while downregulating bcl2-associated x protein expression.The effects of rg1 pretreatment were similar to those of p ad/flag-ampkα1.After acute renal i/r injury, serum creatinine, blood urea nitrogen, ldh activity, and oxidative stress in renal tissue significantly increased.Rg1 pretreatment upregulated ampkα1 expression, which protects against acute renal i/r injury by maintaining renal function homeostasis, inhibiting oxidative stress, and reducing apoptosis.Compound c, a specific inhibitor of ampk, reversed the effects of rg1.In summary, rg1 pretreatment upregulated ampkα1 expression, inhibited oxidative stress, maintained mitochondrial function, improved energy metabolism, reduced apoptosis, and ultimately protected renal tissue against acute renal i/r injury.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Genetic Analysis Reveals Different Mechanisms of IL-5 Involved in the Development of CAD in a Chinese Han Population

Coronary artery disease (cad) is a complex disease and the leading cause of death worldwide.It is caused by genetic and environmental factors or their interactions.Candidate gene association studies are an important genetic strategy for the study of complex diseases, and multiple variants of inflammatory cytokines have been found to be associated with cad using this method.Interleukin-5 (il-5) is an important inflammatory immune response factor that plays a role in a various inflammatory disease.Clinical tests and animal experiments indicated that il-5 is involved in cad development, but the exact mechanisms are unclear.This study investigated the genetic relationship between the single nucleotide polymorphisms (snps) in il5 and cad.Materials and methods.Based on the chinese han population, we collected 1,824 patients with cad and 1,920 control subjects and performed a two-stage case-control association analysis for three snps in il5 (rs2057687, rs78546665, and rs2069812) using the high resolution melt (hrm) technology.Logistic regression analyses were applied to adjust for traditional risk factors for cad and to perform haplotype and gene interaction analyses.Multiple linear regression analyses were used to study relationships between the selected snps and serum lipid levels.Results.In this study, two-stage case-control association analysis revealed that the allele and genotype frequency distributions of the three il5 snps were not statistically significant between the case and control groups.In addition, none of the il5 haplotypes were associated with cad.Further stratified analyses were conducted by sex, age, hypertension, and disease status, respectively, and the results revealed that the rs2057687 and rs2069812 of il5 were associated with cad in the male group ( p adj = 0.025 , or, 0.77 (95% ci, 0.62-0.97); p adj = 0.016 , or, 0.82 (95% ci, 0.70-0.97), respectively); the rs2057687 and rs78546665 of il5 were associated with late-onset cad ( p adj = 0.039 , or, 0.78 (95% ci, 0.62-0.99); p adj = 0.036 , or, 1.46 (95% ci, 1.02-1.53), respectively); the rs2069812 of il5 was associated with cad in the hypertension group ( p adj = 0.036 , or, 0.84 (95% ci, 0.71-0.99)); and none of the snps in il5 were associated with different cad states (anatomical cad and clinical cad).In addition, the association between snps and the serum lipid levels indicated that rs78546665 was positively correlated with triglyceride levels ( p = 0.012 ).Finally, snp-snp interaction analyses revealed that interactions of rs2057687 and rs2069812 were associated with cad ( p adj = 0.046 , or, 0.77 (95% ci, 0.13-4.68)).Conclusion.This study suggested that the common variants of il5 might play a role in cad by affecting the risk factors for cad and through snp-snp interactions, which provides a new target for specific treatment of cad patients and a theoretical basis for personalized medicine.

Journal: Oxidative Medicine and Cellular Longevity (2023)
Publication types: Research Article;
FXYD6 Regulates Chemosensitivity by Mediating the Expression of Na+/K+-ATPase α 1 and Affecting Cell Autophagy and Apoptosis in Colorectal Cancer

Chemoresistance is a challenge of improving chemotherapeutic efficacy and prolonging survival time for patients with colorectal cancer (crc); it is the major cause of frequent recurrence, rapid metastasis, and poor prognosis for crc patients.Fxyd6 is a regulator of na+/k+‐atpase which is depressed in chemoresistant crc patients.However, the biological roles of fxyd6 on regulating chemoresistance in crc are still unclear.Methods .Gse3964 and gse69657 from geo data sets were used to analyze the relationship of genes and chemoresistance.The fxyd6 expression level was detected by western blotting and real‐time pcr and also analyzed from tcga data set.To investigate the functional role of fxyd6 and atp‐ α 1, fxyd6 and atp‐ α 1 functional cell models were constructed.Drug sensitivity and cell proliferation were performed by mtt assay.Autophagy and apoptosis were conducted by autophagy fluorescence analysis and flow cytometric analysis, respectively.Autophagy and apoptosis markers were tested by western blotting.Results .Fxyd6 was downregulated in crc resistant patients and irinotecan‐ (iri‐) resistant sw620 cells (sw620/iri).Fxyd6 silence inhibited cell apoptosis and enhanced prosurvival autophagy, whereas fxyd6 overexpression produced the opposite effect which alleviated the drug resistance to irinotecan and oxaliplatin of crc cells.Fxyd6 regulates chemosensitivity by mediating the expression of na+/k+‐atpase α 1 and affecting cell autophagy and apoptosis in colorectal cancer.Conclusion .Fxyd6 functions as a chemosensitivity regulator which may predict the curative effect of chemotherapy in colorectal cancer.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Free Triiodothyronine Is Independently Associated with Nonalcoholic Fatty Liver Disease in Hospitalized Type 2 Diabetes Mellitus Patients

Free triiodothyronine (ft3) is an independent risk factor for nonalcoholic fatty liver disease (nafld) in patients with euthyroid.However, whether ft3 has an independent effect on nafld in a population of type 2 diabetes remains unknown.The purpose of this study was to identify the potential role of ft3 in nafld with t2dm.Design .A cross‐sectional study.Patient .A total of 859 t2dm patients who met the inclusion criteria were included.There were 506 t2dm patients without nafld and 353 t2dm patients with nafld.Methods .The independent samples t ‐test or wilcoxon rank sum test were used for continuous variables of different distribution types, while the chi‐square test was used for categorical variables.Pearson correlation analysis and linear regression were used to analyze the correlation between ft3 and clinical measurements and biochemical indicators.Multivariate logistic regression analysis was used to determine independent predictors.Results .Patients with nafld had higher bmi, sbp, and dbp, longer duration of t2dm, and higher islet function index, blood glucose index, liver function index, renal function index, blood lipid index, and ft3.We also found that ft3 was affected by other five indicators, including alt, cr, ggt, tc, and ldl‐c only in the nafld group but not in the non‐nafld group.Ft3 was significantly associated with nafld in t2dm patients, and the prevalence of nafld increased gradually from the lowest ft3 tertile to the highest ft3 tertile ( p for trend &lt; 0.001).Conclusion .Ft3 is independently associated with nafld in hospitalized t2dm patients after rigorous adjustment for various metabolic parameters.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Fetal Congenital Cardiac and Vascular Disorders Associated with Sertraline Treatment during Pregnancy: Analysis of FAERS Data

Sertraline is one of the most commonly used antidepressants worldwide and is one of the first‐choice treatments for depression during pregnancy.This study is aimed at testing the possible association between sertraline intrauterine exposure and congenital cardiac and vascular disorder occurrences by assessing the publicly available us food and drug administration adverse event reporting system (faers).Methods .Disproportionality analysis and bayesian analysis were used to mine faers for suspected congenital cardiac and vascular disorder data for sertraline intrauterine exposure from the first quarter of 2004 to the second quarter of 2021.Results .Among the 914 cases of sertraline used with congenital cardiovascular disease in the faers database, the reporting areas were mainly in the united states and europe.The number of adverse events reported every year since 2004 has no many differences.Congenital anomalies are the most frequently reported serious clinical outcome.Among the 69 positive signals detected from 914 cases, 31 were invalid signals, and 38 were valid signals according to criteria.The most common ones are heart disease congenital, atrial septal defect, ventricular septal defect, patent ductus arteriosus, and persistent fetal circulation.Conclusions .Mining faers data can analyze and study the adverse reactions of sertraline in a more comprehensive and in‐depth manner, thereby effectively reducing the risk of clinical medication.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Fermented Carrot Pulp Regulates the Dysfunction of Murine Intestinal Microbiota

It was the focus of attention that probiotic control drink was packed with prebiotic nutrients and lactic acid bacteria.So, this study is aimed at revealing that the fermented carrot pulp regulation and protection function to the intestinal microecological disorders usually induced by antibiotic treatment.First, we study on lactobacillus fermentation conditions and effects on the secondary metabolism of fermented carrot juice, get its phenolic acids up, and get its flavonoids down.Then, establishment of the dysbacteriosis mouse model was used to validate the fermented carrot pulp prevention and treatment of intestinal microbiota imbalance.After the antibiotic treatment, the mice showed impotence, laziness, slow movement, weight loss, thin feces, dull hair, and anal redness, while the mice in the control group were all normal in terms of the mental state, diet, weight, and bowl movement.Along with the treatment, the abnormal conditions of the mice in the model group and natural recovery group improved in different degrees, indicating that the fermentation treatment is of help to the intestinal microbiota recovery.The fermentation-treated group of mice recovered close to normal that the diarrhea disappeared, and the weight gain, mental state, and the feces became normal.The serum antioxidant (sod, gsh, and mda) levels of the mice were checked.The superoxide dismutase (sod) levels and glutathione (gsh) levels in the ordinary fermentation-treated group and probiotic fermentation-treated group were significantly increased compare to the natural recovery group.The malondialdehyde (mda) levels showed great differences between the fermentation-treated groups and the blank group.At last, the 16s rna analysis revealed that the microbiota richness and diversity in probiotic fermentation (j) are much higher than those in the model group (h), ordinary fermentation group (i), and blank group (g).Groups j and i are of significantly higher antioxidant level than group h; however, only the glutathione (gsh) level in group j increased dramatically but not those in the other three groups.Antibiotic treatment-induced mouse intestinal microecological disorder reduce the microbiota richness and diversity.Prebiotics fermented carrot pulp treatment can help in the recovery from the microbiota richness and diversity level prior to the antibiotic treatment, which suggests it can regulate and protect the murine intestinal microbiome.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Expression Profile of MAGE-B1 Gene and Its Hypomethylation Activation in Colon Cancer

Cancer‐testis (ct) genes are typically expressed in the testes; however, they have been linked to aberrant expression in a variety of malignancies.Mage-b family genes are an example of ct genes.Therefore, the overarching objective of this study was to examine the expressions of mage-b family genes in several patients with colon cancer (cc) to see if they might be employed as cancer biomarkers in the early phases of cancer detection and to improve treatment.In this investigation, rt‐pcr was used to analyze mage-b family genes in neighboring normal colon (nc) tissue from 10 cc patients.In addition, the effect of dna demethylation on the expression status of the mage-b1 gene was evaluated by rt‐pcr in hct116 and caco‐2 cells and by q rt‐pcr for hct116 only after treating both cc cell lines with varying concentrations of 5‐aza‐2 ’ ‐deoxycytidine (1.0, 5.0, and 10.0 μ m) for 48 or 72 hours.All mage-b family genes except for mage-b1 showed weak bands in several samples of nc tissues: mage-b2 , mage-b3 , mage-b4 , mage-b5 , and mage-b6 genes were observed in 40%, 50%, 40%, 30%, and 60% of the nc samples, respectively.Nonetheless, they had strong bands in multiple samples of cc tissues, with 70%, 90%, 60%, 50%, and 90% of the cc samples, respectively.Interestingly, mage-b1 was detected in 60% of cc tissues but not in nc tissues, suggesting that it is a potential biomarker for early cc detection.Mage-b1 expression was not observed in either untreated or dmso‐treated hct116 cells after 48 or 72 hours of treatment.However, according to the rt‐pcr and q rt‐pcr results, the mage-b1 gene was overexpressed in the hct116 cells treated with three different concentrations of 5‐aza‐2 ’ ‐deoxycytidine.This shows that demethylation plays a crucial role in mage-b1 expression activation.

Journal: BioMed Research International (2022)
Publication types: Research Article;