syedzayyan/paper_mill_benchmark huggingface dataset:
E-Health Ultrasonic Diagnostic Monitoring for Analysis of Cardiac Insufficiency and Neuronal Regulation in Patients with Sepsis in Emergency Department under Image Reconstruction Algorithm

An anisotropic diffusion filtering- (adf-) ultrasound (adf-u) for ultrasound reconstruction was constructed based on the adf to explore the diagnostic application of ultrasound imaging based on electronic health (e-health) for cardiac insufficiency and neuronal regulation in patients with sepsis.The 144 patients with sepsis were divided into an experimental group (78 patients with cardiac insufficiency) and a control group (66 patients with normal cardiac function), and another 58 healthy people were included in a blank control.The ultrasound examination was performed on all patients.In addition, new ultrasound image reconstruction and diagnosis were performed based on adf and e-health, and its reconstruction effects were compared with those of the bilateral filter-ultrasonic (bfu) algorithm and the wavelet threshold-ultrasonic (wtu) algorithm.The left and right ventricular parameters and neuropeptide levels were detected and recorded.The results show that the running time, average gradient (ag), and peak signal-to-noise ratio (snr) (psnr) of the adf-u algorithm were greater than those of the bilateral filter-ultrasonic (bfu) and wavelet threshold-ultrasonic (wtu), but the mean square error (mse) was opposite ( p &lt; 0.05 ); the left ventricular end-systolic volume (lvesv) and the vertical distance between the mitral valve e-point to septal separation (epss) in the experimental group were higher than those in the control and blank group, while the left ventricular ejection fraction (lvef), stroke volume (sv), cardiac output (co), and left ventricular fractional shortening (lvfs) were opposite ( p &lt; 0.05 ); the systolic peak velocity of right ventricular free wall tricuspid annulus (sm) and pulmonary valve blood velocity (pvbv) in the experimental group were lower than those of the control group and blank group ( p &lt; 0.05 ); the messenger ribonucleic acid (m rna) of proopiomelanocortin (pomc) and cocain and amphetamine-regulated transcript (cart) was higher than the m rna in control group and blank group ( p &lt; 0.05 ).In short, the adf-u algorithm proposed in this study improved the resolution, snr, and reconstruction efficiency of e-health ultrasound images and provided an effective reference value for the diagnosis of cardiac insufficiency and neuronal adjustment analysis in patients with sepsis in the emergency department.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Efficacy of Sertraline Combined with Cognitive Behavioral Therapy for Adolescent Depression: A Systematic Review and Meta-Analysis

The efficacy of antidepressant drugs combined with psychotherapy is controversial; hence, this meta-analysis was conducted to assess the efficacy of the combination therapy.Methods.Relevant literature was searched in pub med, web of science and embase, chinese databases cnki, and wan fang data.We included the literature on the comparison of the sertraline combined with cognitive behavioral therapy (cbt) and each treatment alone for adolescent depression published in 2000-2021.Meta-analysis was performed using stata16.0 software.Results.A total of 421 relevant articles were retrieved, and 14 studies were finally included.In comparison with the control group (sertraline), sertraline combined with cbt achieved higher response rate ( or = 5.07 , 95% ci: 3.00, 8.58) and lower incidence of adverse reactions ( or = 0.43 , 95% ci: 0.24, 0.75).Before treatment, there were no significant differences in depression score, anxiety score, and symptom self-rating scale score between the two groups.After treatment, depression score ( smd = − 2.79 , 95% ci: -3.64, -1.94), anxiety score ( smd = − 1.22 , 95% ci: -1.96, -0.47), and symptom self-rating scale score ( smd = − 1.73 , 95% ci: -3.19, -0.27) were significantly lower in the combined treatment group than in the control group.Conclusion.Although the number of comparative trials is small, this study shows that sertraline is effective for adolescent depression, but sertraline combined with cbt is more effective.The latter can significantly reduce the incidence of depressive symptoms, anxiety, and adverse reactions in patients.Therefore, this combination therapy is recommended for the clinical treatment of adolescent depression.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Meta-Analysis;
Efficacy of Neoadjuvant Chemotherapy plus Limb-Sparing Surgery for Osteosarcoma and Its Impact on Long-Term Quality of Life

To assess the efficacy of neoadjuvant chemotherapy plus limb-sparing surgery for osteosarcoma and its impact on long-term quality of life.Methods.Between august 2016 and december 2018, 90 patients with osteosarcoma treated in nanchong central hospital were recruited and divided at a ratio of 1 : 1 to receive limb-sparing surgery (control group) or limb-sparing surgery plus neoadjuvant chemotherapy (study group) by random number table methods.The clinical endpoints were clinical efficacy and long-term quality of life.Results.Limb-sparing surgery plus neoadjuvant chemotherapy was associated with a significantly higher efficacy versus limb-sparing surgery alone.Limb-sparing surgery plus neoadjuvant chemotherapy resulted in a significantly higher enneking score and a higher good function rating of patients versus limb-sparing surgery.The two groups showed a high but similar 1-year survival rate.Patients given limb-sparing surgery plus neoadjuvant chemotherapy showed significantly higher 2-year and 3-year survival and a longer mean survival versus those receiving limb-sparing surgery alone.Limb-sparing surgery plus neoadjuvant chemotherapy resulted in significantly higher scores of role emotional, mental health, physical function, and social function and a lower bodily pain score than limb-sparing surgery alone.Limb-sparing surgery plus neoadjuvant chemotherapy was associated with significantly lower fatigue, nausea and vomiting, dyspnea, constipation, and diarrhea scores and a significantly higher health status score versus monotherapy of limb-sparing surgery.Conclusion.Neoadjuvant chemotherapy plus limb-sparing surgery improves the postoperative limb function and long-term quality of life of patients with osteosarcoma, which shows great potential for clinical promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Efficacy of Laparoscopic Radical Resection Combined with Neoadjuvant Chemotherapy and Its Impact on Long-Term Prognosis of Patients with Colorectal Cancer

The aim of the study is to examine the efficacy of laparoscopic radical resection of colorectal cancer combined with neoadjuvant chemotherapy and its impact on the overall prognosis of patients with colorectal cancer (cc).Methods.A total of 80 cc patients hospitalized and treated at our hospital between november 2019 and june 2021 were selected at random as research subjects and divided equally into two groups: the surgical group (n = 40) and the combination group (n = 40).Patients in the surgical group were treated with laparoscopic radical resection, while patients in the combination group received laparoscopic radical resection combined with neoadjuvant chemotherapy.The two groups were compared in terms of surgery-related indicators, tumor markers (serum carcinoembryonic antigen (cea), glycoprotein 199 (ca199), vascular endothelial growth factor (vegf), and matrix metalloproteinase 9 (mmp9)), postoperative complications, and 1–3 years postoperative survival rate and recurrence rate.Results.The surgical duration of the combination group was significantly shorter than the surgical group ( p &lt; 0.05 ).No significant differences were found in intraoperative blood loss, time to get out of bed, exhaust time, or hospital stay between the two groups ( p &lt; 0.05 ).In the combination group, serum tumor markers (carcinoembryonic antigen (cea), carbohydrate antigen 199 (ca199), vascular endothelial growth factor (vegf), and matrix metalloproteinase 9 (mmp9)) were markedly lower than those in the surgical group ( p &lt; 0.05 ).The combination group exhibited fewer postoperative complications than those in the operation group ( p &lt; 0.05 ).In the combination group, the 1–3 years postoperative survival rate was higher, while the 1–3 years postoperative recurrence rate was considerably lower than that in the surgical group ( p &lt; 0.05 ).Conclusion.Cc patients benefit well from laparoscopic radical resection coupled with neoadjuvant chemotherapy.The approach is efficient in lowering blood tumor markers in patients and lowering the risk of surgery-related complications.It has the potential to enhance patients’ long-term prognoses, allowing them to live longer and lower their chance of recurrence.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Efficacy of Fuyuan Xingshen Decoction Combined with Butylphthalide Sodium Chloride Injection in the Treatment of Acute Cerebral Infarction and Its Effect on Hemodynamics

This study aims to determine the curative effect of fuyuan xingshen decoction combined with butylphthalide sodium chloride injection in acute cerebral infarction (aci) treatment and its effect on hemodynamics.Methods.In our hospital, a total of 84 aci patients from may 2020 to february 2022 were randomly divided into two groups: observation and control (n = 42 each).Fuyuan xingshen decoction in combination with butylphthalide sodium chloride injection was provided to the observation group, while the control group received butylphthalide sodium chloride injection alone.Both groups’ clinical efficacy was observed.Before and after treatment, the neurological function of the two groups was evaluated using the national institutes of health stroke scale (nihss), while the daily living ability of both groups was determined using the barthel index rating scale.Both groups were investigated for their cognitive function, before and after treatment, by using the mini-cog scale and montreal cognitive assessment (mo ca) scale.The pulsatility index (pi), peak velocity (vp), and mean velocity (vm) of intracranial arteries were measured by transcranial doppler ultrasonography before and after treatment.The levels of ubiquitin carboxy-terminal hydrolase-1 (uch-l1), fibulin-5, and visinin-like protein-1 (vilip-1) in serum and the expression levels of mi r-34c, mi r-25, and mi r-182 in peripheral blood of the two groups were compared.Both groups were observed for the incidence of adverse reactions.Results.Compared with the control (71.43%), the observation group exhibited a significantly higher effective rate of around 90.48%.In the observation group, the improvement in nihss, barthel index, mini-cog, and mo ca scores; hemodynamic indexes including vp, pi, and vm; serum uch-l1, fibulin-5, and vilip-1 levels; and the mi r-34c, mi r-25, and mi r-182 expression levels in peripheral blood was better than the control group, with significant difference (all p &lt; 0.05 ).The incidence of adverse reactions between the groups demonstrated no significant differences ( p &gt; 0.05 ).Conclusions.Fuyuan xingshen decoction combined with butylphthalide sodium chloride injection can effectively improve patients’ daily living ability, neurological function, cognitive function, and cerebral hemodynamics in the treatment of aci, with good effect and safety.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Efficacy of Dapagliflozin Combined with Lifestyle Intervention in Obesity Control

To explore the best treatment of obesity in middle and old age.Methods.80 obese patients in our hospital from january 2020 to december 2021 were randomly divided into the control group and the intervention group according to the numerical table method.The control group was treated with lifestyle intervention, while the intervention group was treated with dapagliflozin combined with lifestyle intervention.The effects of body weight, body mass index (bmi), waist circumference, and blood lipids (ldl, hdl, tc, and tg) were measured and compared.Anxiety and depression scores were assessed using the 2018 revised anxiety and depression scale.Results.There were no significant differences in body weight, bmi, and waist circumference between the control group and the intervention group before treatment.After treatment, the weight, bmi, and waist circumference of the intervention group were lower than those of the control group, and the difference was statistically significant ( p &lt; 0.05 ).After treatment, ldl, tc, and tg in the two groups were decreased, and hdl was significantly increased ( p &lt; 0.05 ).After treatment, the blood lipid level in the intervention group was significantly lower than that in the control group ( p &lt; 0.05 ).Anxiety and depression symptoms improved in both groups, and there were no serious adverse effects.Conclusion.Dapagliflozin in combination with a lifestyle intervention effectively and safely treats excess weight in middle-aged and older adults, reverses obesity-related markers, and improves psychological symptoms.Its curative effect is better than that of using lifestyle intervention alone.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Efficacy and Safety of Jinshuibao Capsule in Diabetic Nephropathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

This systematic review was able to evaluate the clinical evidence of jsbc in the randomized controlled trial (rct) of diabetic nephropathy.Methods.The chinese and english literatures published in pub med, cochrane library, vip, wanfang data, cnki, and cbm before july 30, 2019, were retrieved.This study includes only randomized controlled trials of treatments related to diabetic nephropathy.We assessed the methodological quality of the subjects involved according to the assessment criteria in 5.3.3 of the cochrane assessment manual.Rev man 3.5.5 software was used to analyze the relevant data, meta-analysis, and inverted funnel analysis chart.Results.This study included 26 rcts, including 4676 patients in total (2342 cases in the experimental group and 2334 cases in the control group).The results of 8 randomized controlled trials showed that urinary microprotein excretion rate (uaer) significantly decreased ( p &lt; 0.0001 ) before and after treatment of diabetic nephropathy.Conclusion.The available clinical evidence has suggested that jsbc combined with western drugs is differentially effective in the treatment of diabetic nephropathy.The combination of jsbc with western medicine is more effective.However, due to the small amount and low quality of the included literatures, the current evidence is not certain to be fully clinically applicable.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Meta-Analysis;
Effects of Staged Nursing Care on Neuroendoscopic Transsphenoidal Pituitary Adenoma Resection and Postoperative Complications

The purpose of this study was to determine whether staged nursing had an impact on the outcome of neuroendoscopic transsphenoidal pituitary tumor resection and postoperative complications.Methods.As research participants, we chose 88 individuals with pituitary adenomas who were treated at our institution between february 2020 and november 2021; all patients received endoscopic transsphenoidal pituitary adenoma excision.The patients were randomly divided into two groups: the routine group (n = 44) and the stage group (n = 44).Patients in the routine group received care according to the routine nursing mode, and patients in the stage group received care according to the stage nursing mode.The staged nursing interventions included preoperative, intraoperative, and postoperative nursing.Postoperative recovery-related indicators such as the self-rating anxiety scale (sas) and a self-rating depression scale (sds), contentment, comfort, and postoperative complications were compared between the two groups.Results.The postoperative recovery-related indexes of patients in the stage group were significantly lower than those in the routine group ( p &lt; 0.05 ); the sas and sds scores in the stage group after treatment were significantly lower than those in the routine group ( p &lt; 0.05 ); patients in the stage group were significantly more satisfied with their treatment after treatment than those in the routine group ( p &lt; 0.05 ); patients in the stage group were significantly more comfortable after treatment than those in the routine group ( p &lt; 0.05 ); a significantly lower incidence of postoperative complications was observed in the stage group compared to the routine group ( p &lt; 0.05 ).Conclusion.Patients with neuroendoscopic transsphenoidal pituitary tumor excision benefit greatly from staged nursing.The nursing approach may successfully assure the procedure’s smooth completion, boost patients’ postoperative recovery, and reduce patients’ worry, despair, and other unpleasant feelings.The nursing approach may successfully increase clinical satisfaction and comfort of patients by minimizing the likelihood of postoperative problems, and it is well-suited for practical use.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Effects of Self-Care plus Forecasting Nursing on the Treatment Outcomes and Emotions in Patients with Nasopharyngeal Carcinoma after Radiotherapy

To explore the effects of self-care plus forecasting nursing on the treatment outcomes and emotions in nasopharyngeal carcinoma patients undergoing radiotherapy.Methods.Eighty nasopharyngeal carcinoma patients after radiotherapy admitted to our hospital from february 2020 to august 2021 were selected.The patients were allocated into an observation group (n = 40) and an experimental group (n = 40) according to different nursing protocols.The observation group received traditional nursing intervention, whereas the experimental group received self-care plus forecasting nursing intervention.The levels of the indexes (quality of life, score on the zung self-rating anxiety scale (sas), score on the zung self-rating depression scale (sds), and adverse reaction) were compared between the two groups.Results.The score of the experimental group for the quality of life was significantly higher than that of the observation group ( p &lt; 0.05 ); the sas and sds scores of the experimental group after nursing intervention were significantly lower than those of the observation group ( p &lt; 0.05 ); the incidence of adverse reactions in the experimental group during radiotherapy was significantly lower than that of the observation group ( p &lt; 0.05 ).Conclusion.The self-care plus forecasting nursing intervention is effective in postradiotherapy patients with nasopharyngeal carcinoma.The technique is proved effective to improve the quality of life, reduce anxiety and depression, and decrease the incidence of adverse reactions in patients during treatment.These features make the technique worthy of a wider clinical application.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Effects of Remifentanil and Sufentanil Anesthesia on Cardiac Function and Serological Parameters in Congenital Heart Surgery

In this study, we have investigated feasibility of remifentanil and sufentanil anesthesia in children with congenital heart disease surgery and its effects on cardiac function and serological parameters.For this purpose, a retrospective study was conducted on 120 children with congenital heart disease who underwent repair of ventricular septum or atrial septum in our hospital, specifically from january 2016 to january 2018, and 60 patients in each group were randomly divided into the control and treatment groups, respectively.The control group was anesthetized with sufentanil, and the treatment group was anesthetized with remifentanil.The heart function, serological indexes, and adverse reactions were observed and compared.We have observed that there was no significant difference in hr levels between these groups ( p &gt; 0.05 ), but sdp and dbp values of the two groups were decreased after anesthetic induction ( p &lt; 0.05 ).Ach, cortisol, and lactic acid in the treatment group were significantly lower than those in the control group, and the difference was statistically significant ( p &lt; 0.05 ).The incidence of bradycardia, nausea and vomiting, hypotension, muscle rigidity, and respiratory depression in the treatment group was 16.67% lower than that in the control group ( p &lt; 0.05 ).Remifentanil has less influence on hemodynamics and a better analgesic effect than fentanyl in inhibiting stress response in congenital heart surgery, which provides reference and basis for children congenital heart surgery.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Clinical Study;
Effects of Recombinant Human Epidermal Growth Factor Eye Drops Combined with Phacoemulsification on Short- and Long-Term Visual Acuity Recovery and Related Dry Eye Complications in Patients with Senile Cataract

To investigate the effects of recombinant human epidermal growth factor eye drops combined with phacoemulsification on short- and long-term visual acuity recovery and related dry eye complications in patients with senile cataract.Methods.Sixty patients with senile cataract cured from january 2019 to january 2021 were enrolled in our hospital.The patients in the control group were arbitrarily assigned into the control and the research group.The former group received phacoemulsification, and the latter group received recombinant human epidermal growth factor (rh egf) eye drops combined with phacoemulsification.The curative effect, the incidence of xerophthalmia, short-term and long-term vision improvement, changes of corneal endothelial cells, serum factors, and life quality scores were compared.Results.The effective rate of the research group was 90.00%, and the effective rate of the control group was 66.67%; the curative effect of the research group was higher than that of the control group ( p &lt; 0.05 ).The incidence of dry eye in the research group was lower than that in the control group ( p &lt; 0.05 ).The short-term and long-term visual acuity improvement effect of the research group was better than that of the control group ( p &lt; 0.05 ).After treatment, the density of corneal endothelial cells in the research group was higher than that in the control group, while the proportion of hexagonal cells and the coefficient of variation of corneal endothelial cells in the research group were lower than those in the control group ( p &lt; 0.05 ).After treatment, il-6 and tnf-α in the research group were lower than those in the control group ( p &lt; 0.05 ).Compared with the control group, the physical function, psychological function, social function, and healthy self-cognition scores of the research group were all lower ( p &lt; 0.05 ).Conclusion.Cataract is the leading cause of blindness in the world.With the continuous improvement of cataract phacoemulsification technology, the incidence of some serious complications has gradually lessened.Xerophthalmia is one of the most obvious and predictable complications after cataract surgery and may affect the recovery of postoperative visual acuity.Recombinant human epidermal growth factor eye drops can effectively enhance the visual acuity of patients, promote the curative effect, and strengthen the life quality.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;