syedzayyan/paper_mill_benchmark huggingface dataset:
The Analysis of Potential Diagnostic and Therapeutic Targets for the Occurrence and Development of Gastric Cancer Based on Bioinformatics

Gastric cancer is among the most common malignant tumors of the digestive system.This study explored the molecular mechanisms and potential therapeutic targets for gastric cancer occurrence and progression using bioinformatics.Methods.The gastric cancer microarray dataset was downloaded from the gene expression omnibus (geo) database.The r package was used for data mining and screening differentially expressed genes (degs).Gene ontology (go) analysis and kyoto encyclopedia of gene and genome (kegg) pathway analysis were performed using the database for annotation, visualization, and integrated discovery (david).Based on the protein-protein interaction (ppi) network analysis, core targets and core subsets were screened.Then, the relationship between the expression level of the core genes and the prognosis of gastric cancer patients was analyzed using the gene expression profiling interactive analysis (gepia) database.Results.Using the gse19826 and gse54129 datasets, a total of 550 degs were identified, including 248 upregulated and 302 downregulated genes.Go and kegg analyses showed that the upregulated degs were mainly enriched in the extracellular matrix (ecm) organization of the biological process (bp), the collagen-containing ecm of cellular component (cc), and the ecm structural constituent of molecular function (mf).Degs were also enriched in human papillomavirus infections, the focal adhesion pathway, pi3k-akt signaling pathway, and among others.The downregulated degs were mainly enriched in digestion, basal part of the cell, and aldo-keto reductase (nadp) activity.And the above pathways were enriched primarily in the metabolism of xenobiotics by cytochrome p450, drug metabolism-cytochrome p450, and retinol metabolism.Five core genes, including col1a2, col3a1, bgn, fn1, and vcan, were significantly highly expressed in gastric cancer patients and were associated with poor prognosis.Conclusion.This study identified new potential molecular targets closely related to gastric cancer occurrence and development via mining public data using bioinformatics analysis methods.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Test of Ultimate Bearing Capacity of Building Concrete Structures in Earthquake Area Based on Virtual Reality

In order to solve the poor matching ability between concrete structures of traditional architectural space optimization design methods, it leads to the problem of low space optimization ratio, so based on virtual reality technology, the author proposes a new method for optimizing the space of concrete structure buildings.Using virtual reality technology to improve the basic structure of building space, reorganize the form through the design space, and optimize the design of the concrete structure building space function; based on the test model of virtual reality technology, design the matching method of concrete structure, increase the proportion of building space optimization, and adopt linear buckling method, geometric nonlinear method, and double nonlinear analysis method; the ultimate bearing capacity of steel structures of residential buildings in earthquake areas is tested.Experimental results show that for the simple structure building space, the average optimization ratios are 97.17% and 96.71%, respectively; for the complex structure building space, under the proposed optimization design, the average optimization ratio is maintained at 94.34%, and the error between the stress prediction value of the finite element model and the axial stress obtained by testing is less than 6%.Compared with the traditional space optimization design, in the proposed space optimization design method, the proportion of building space optimization is higher; it can be seen that the virtual reality technology has a better matching effect on the concrete structure, and the accuracy of the ultimate bearing capacity value obtained by prediction is high.

Journal: Journal of Sensors (2022)
Publication types: Research Article;
Tennis Technology Recognition and Training Attitude Analysis Based on Artificial Intelligence Sensor

In order to solve the problem of traditional tennis serving technique teaching, subjective, and experience-based teaching methods, the author proposes a method to extract tennis training movements based on artificial intelligence sensor video analysis.This method requires the use of ordinary cameras and computer technology; video analysis technology is used to guide tennis teaching and training.The result obtained is as follows: in the experimental group and the control group, at the end of the teaching stage, the movement characteristics of each link of the body are quite different, which can reach 15%-20%; when the experimental group and the control group did the “scratching back” movement during the teaching period, at the end of teaching, the students in the experimental group were close to high-level tennis players in their movement skills, and the movement gap was only about 5%.It is proved that the method proposed by the author provides an objective and scientific basis for measuring the referee’s penalty level.In the grass-roots tennis teaching and training, it has important value and significance and has a great promotion prospect.

Journal: Journal of Sensors (2022)
Publication types: Research Article;
Study on the Mechanism of Treating Femoral Head Necrosis with Drynariae Rhizoma Based on Network Pharmacology

Through the network pharmacology thought, the action target of the active ingredients of drynariae rhizoma was predicted, and the mapping was combined with the related targets of onfh, and the key nodes of interaction were identified for enrichment analysis, so as to comprehensively explore the pharmacological mechanism of drynariae rhizoma against onfh.The main active ingredients of drynariae rhizoma were screened based on pharmacokinetic characteristics in pharmacokinetic database and analysis platform of tcm system (tcmsp).We used the organic small molecule bioactivity database (pub chem) and swiss target prediction database to predict related targets based on 2d or 3d structural similarity and then mined the known onfh therapeutic targets through the human mendelian genetic database (omim) and pubmed texts.Combined with the predicted targets, string database was imported to construct the op target interaction network diagram of bone fracture therapy.Cyto nca software was used to topology the key nodes of interaction according to relevant node parameters, and string was imported again to construct the protein interaction network diagram.Finally, biological functions and metabolic pathways of key nodes were analyzed through david database.It was revealed that drynariae rhizoma may regulate stem cells, osteoblasts, osteoclasts, and immune cells through multiple pathways, including proliferation, differentiation, immunity, and oxidative stress.Conclusion: pharmacological studies based on network indicate that drynariae rhizoma may participate in the regulation of several major signaling pathways through direct or indirect action targets and affect the proliferation and differentiation of multiple types of cells, thus playing an anti-onfh role, which provides a scientific basis for explaining the material basis and mechanism of its anti- onfh.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Study on Environmental Art Design Based on Ecology Concept

Ecological design concept is a design concept aimed at advocating green environmental protection and sustainable development, which is widely used in different cases of environmental design including urban and kindergarten.In our study, using literature research, case reference, and field research as research methods, through the theoretical research of domestic and foreign kindergarten environment design and interpretation of typical cases to summarize the ecological design method and design strategy, can be further applied in larger field such as urban, basin, and/or region.Then, take “chenguang” kindergarten in beijing as example to analyze ecological element in there.Aiming at ecological landscape, ecological humanities, and ecological experience as the goal, the kindergarten’s architectural appearance and indoor and outdoor environment have been transformed and redesigned.Ecological principle and ecological strategy from our study present an important reference meaning in improving the quality of urban space environment and shaping a good city image which are of great significance.

Journal: Journal of Sensors (2022)
Publication types: Research Article;
Spatiotemporal Variation of Surface Sediment Quality in the Xiamen Sea Area, China

The study analyzes the survey data on the surface sediments in 355 stations in xiamen sea area during 2004‐2006, 2007‐2009, 2010‐2013, and 2014‐2016.The result finds that contents of toc, sulfide, and oils in the surface sediments were generally low but showed significant spatial differences ( p &lt; 0.05) in most cases, with toc in the west sea area (ws) staying significantly higher than other sea areas.Xiamen sea area suffered universal heavy metal pollution mainly from cu and zn for years in the ws, the jiulong river estuary (je), and the east sea area (es), and the heavy metal pollution index (hpi) exhibited significant spatial differences across the four periods ( p &lt; 0.05).With the source of heavy metals in the ws being mainly related to human activities, cu and zn were related to the development of port shipping and pb to aquaculture.The heavy metal pollution in je was mainly related to the input of rivers emptying into the sea.The high cu content in the es was related to the direct discharge of massive domestic sewage into the sea at the time.From 2004 to 2016, the potential ecological risks of heavy metals in xiamen sea area stayed low.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
Slope Topography Monitoring Based on UAV Tilt Photography Technology and Sensor Technology

In order to solve the problems of high risk and low efficiency of the traditional rock mass structure logging method of open-pit mine slope, this paper proposes a method to improve the geological logging of traditional open-pit mine slope by using uav tilt photography technology.Taking the slope of an open-pit quarry as an example, this method expounds the application method and work flow of uav photography technology in geological logging.The experimental results show that the maximum and minimum absolute errors in the x direction of uav test are 5.1 cm and 1.1 cm, respectively; mae value is 2.90 cm; and rmse value is 3.17 cm.The maximum and minimum absolute errors in y direction are 3.3 cm and 0.9cm, respectively; mae value is 2.36 cm; and rmse value is 2.498 cm.Vertical error refers to the error in elevation.The maximum and minimum absolute errors in z direction are 9.6 cm and 5.7 cm, respectively; mae value is 7.44 cm; and rmse value is 7.54 cm.Conclusion.The reliability of this technology is verified by comparing the occurrence measured by compass and that calculated by point cloud.On this basis, the dominant occurrence of structural plane is divided, which provides basic data support for the analysis of mine slope stability.

Journal: Journal of Sensors (2022)
Publication types: Research Article;
Significance of Circulating Tumor Cells in Nonsmall-Cell Lung Cancer Patients: Prognosis, Chemotherapy Efficacy, and Survival

Introduction.We aimed to evaluate whether circulating tumor cells (ctcs) were the prognostic indicator responsible for chemotherapy and survival of nsclc patients.Methods.Between january 2013 and september 2017, ctcs in the peripheral blood of histologically confirmed stages iii and iv nsclc patients were collected.Blood specimens were obtained on the first day of treatment, chemotherapy 2 and 4 cycles, or targeted therapy 1 and 2 months for ctcs detection.The positive ctc status was defined as one or more ctcs per 7.5 ml.Results.100 patients were enrolled, of which 48 patients (48%) were identified to be ctc positive at baseline.A higher ctc-positive rate was observed in stage iv nsclc patients than stage iii patients (69% vs.40%, p = 0.015 ).Ctc cluster was significantly correlated with disease control rate.Based on the baseline ctc number, patients were divided into low ctc levels (&lt;4 ctcs, ll) and high ctc levels (≥4 ctcs, hl).There was clinically significant shorter median os and os (overall survival) and pfs (progression-free survival) in hl group patients ( p &lt; 0.001 ).Conclusions.The positive association between the ctc number and survival suggested that the baseline ctc number and changes during treatment might be the prognostic information of response rate and overall survival in chinese patients suffering stage iii/iv nsclc.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Signal Optimization of Electronic Communication Network Based on Internet of Things

In order to solve the problem that many people communicate at the same time, there are many external interference factors, and the signal is prone to instability in the process of electronic communication, the author proposes a signal optimization method for electronic communication network based on the internet of things.The method takes the cloud trust mechanism as the dynamic evolution trust relationship between various internet of things electronic communication services, performs explicit and implicit uncertainty conversion, calculates the objective function of data communication network performance, and confirms the control strategy.The positioning information of the network nodes in the communication is added to the communication data packet, and the most stable electronic communication path in the network is obtained to form the network topology structure.The krasovsky method is adopted, and the working state of the nodes of the communication network is divided into the congested state and the normal state, the probability of the two is calculated, and the range of the transition balance is determined, so as to realize the optimization of the stability of the network topology.Experimental results show that the transmission rate of this method has been maintained at about 180 kb/s; although there is fluctuation, the fluctuation value is small and the transmission rate is very stable.Conclusion.It can improve the accuracy of electronic communication of the internet of things and is less affected by external interference factors, and the communication transmission rate is faster.

Journal: Journal of Sensors (2022)
Publication types: Research Article;
Serum TGF-β1 and VEGF Levels Reflect the Liver Hardness and Function in Children with Biliary Atresia

This study further explored the wind direction correlation analysis between serum levels of tgf-β1 and vegf and liver function assessment in children with biliary atresia.Methods.A total of 62 children with biliary atresia (ba) who received surgical treatment in our hospital from october 2020 to october 2021 were selected as the research objects (ba group), and 50 normal healthy children who received routine physical examination in our hospital during the same period were selected as blank control group.Outcome measures included postoperative total bilirubin levels and conjugality of enrolled patients.Bilirubin level, unbound bilirubin level, serum transforming growth factor-beta-1 (tgf-β1), vascular endothelial growth factor (vegf), liver function indicators albumin (alb), alanine aminotransferase (alt), aspartate aminotransferase (ast), and other observation indicators were included.All data in this study were collected and analyzed by spss 23.0 software, and t -test was performed.Results.The serum levels of tgf-β1, vegf, alt, ast, ggt, and liver hardness were significantly higher in children with jaundice than those without jaundice, and the serum alb level was significantly lower than that in children without jaundice ( p &lt; 0.05 ).The levels of tgf-β1 and vegf in ba group were positively correlated with the levels of alt, ast, ggt, and liver hardness ( p &lt; 0.05 ) but negatively correlated with the level of alb ( p &lt; 0.05 ).Conclusion.The levels of serum tgf-β1 and vegf in children with biliary atresia have a certain risk correlation with liver function damage, which will become a research focus on the mechanism of liver fibrosis in the diagnosis and treatment of biliary atresia in children.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Security and Privacy Risk Assessment of Energy Big Data in Cloud Environment

Considering the importance of energy in our lives and its impact on other critical infrastructures, this paper starts from the whole life cycle of big data and divides the security and privacy risk factors of energy big data into five stages: data collection, data transmission, data storage, data use, and data destruction.Integrating into the consideration of cloud environment, this paper fully analyzes the risk factors of each stage and establishes a risk assessment index system for the security and privacy of energy big data.According to the different degrees of risk impact, ahp method is used to give indexes weights, genetic algorithm is used to optimize the initial weights and thresholds of bp neural network, and then the optimized weights and thresholds are given to bp neural network, and the evaluation samples in the database are used to train it.Then, the trained model is used to evaluate a case to verify the applicability of the model.

Journal: Computational Intelligence and Neuroscience (2021)
Publication types: Research Article;
Screening of Differentially Expressed Iron Death-Related Genes and the Construction of Prognosis Model in Patients with Renal Clear Cell Carcinoma

In this study, we used the tcga database and icgc database to establish a prognostic model of iron death associated with renal cell carcinoma, which can provide predictive value for the identification of iron death-related genes and clinical treatment of renal clear cell carcinoma.Methods.The gene expression profiles and clinical data of renal clear cell carcinoma and normal tissues were obtained in the tcga database and icgc database, and the differential genes related to iron death were screened out.The differential genes were screened out by single and multifactor cox risk regression model.R software, “edge” package (version 4.0), was used to identify the dels of 551 transcriptional gene samples and 522 clinical samples.The risk prediction model with genes was established to analyze the correlation between the genes in the established model and clinical characteristics, through the final screening of iron death related genes, it can be used to predict the prognosis of renal clear cell carcinoma and provide advice for clinical targeted therapy.Results.Seven iron death differential genes (cls2, fancd2, phkg2, acsl3, atp5mc3, cisd1, pebp1) associated with renal clear cell carcinoma were finally screened and were refer to previous relevant studies.These genes are closely related to iron death and have great value for the prognosis of renal clear cell carcinoma.Conclusion.Seven iron death genes can accurately predict the survival of patients with renal clear cell carcinoma.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Rituximab May Have Positive Effect on Refractory Nephrotic Syndrome: A Meta-Analysis of Randomized Trials

This study was aimed at demonstrating the role of rituximab (rtx) on the influence of nephrotic syndrome (ns) and on urinary protein which was not significant.Methods.The clinical randomized controlled trials were performed by eight databases.Meanwhile, the confidence interval (ci) of either relative risk or mean difference was set to 95%.Besides, the heterogeneity of the research results is tested by i 2 .Results.A total of 1658 references were found using the search method.This meta-analysis will be done by the ultimately eight different studies.Each study is described as random controlled trial.According to these eight studies, the remission of test group and control group was quite higher (or: 1.60; 95% cl: 1.17, 2.20; p &lt; 0.01 ) than the control group, serum albumin (smd: 4.19; 95% cl: 1.49, 6.89; p &lt; 0.01 ), and urine protein (smd: 0.79; 95% cl: -0.64, 2.22; p = 0.28 ).Despite the fact that the remission rate’s funnel plot was asymmetrically distributed, egger’s test and begg’s test revealed no probable publish bias.Conclusion.The results of this study suggest that rituximab (rtx) may be effective in rns, as evidenced by remission rates and serum albumin.However, the effect on urinary protein was not significant.The clear evidence is missing in this literature.Therefore, large sample, multicenter, low risk of bias clinical studies, as well as basic medical research, is needed.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Meta-Analysis;
Risk Factors and Prognostic Analysis of Gastrointestinal Stromal Tumor Recurrence-Metastasis

Gastrointestinal stromal tumors (gists) are potential malignancies that occur in the digestive tract.This study aimed to investigate the risk factors and prognosis of recurrence and metastasis of gastrointestinal stromal tumor (gist).Methods.From january 2018 to december 2019, 422 patients with gist who received surgery in the first affiliated hospital of wenzhou medical university were enrolled.Their clinical data were retrospectively analyzed, and their follow-ups were continued until march 31, 2022.Subsequently, univariate and multivariate cox analyses, survival curves, and nomograms were adopted to explore the relationship between clinicopathological characteristics and recurrence or metastasis in patients with gist.Results.Univariate and multivariate cox analysis exhibited that the prognosis of patients was affected by tumor rupture ( p = 0.040 ), tumor location ( p &lt; 0.001 ), tumor diameter ( p = 0.016 ), mitotic figures ( p &lt; 0.001 ), and risk grade ( p &lt; 0.009 ).The above variables were selected to create the nomogram for 3-year disease-free survival (dfs).The 3-year the roc (receiver operating characteristic) curves of the nomogram were (0.878 95% confidence interval [ci]: 0.871–0.939).Conclusion.Collectively, risk factors affecting postoperative recurrence or metastasis of gist consist of primary site of tumors, tumor rupture, tumor diameter &gt;10 cm, high-risk tumor classification, and mitotic figures ≥10 per 50 hpfs.And the application of nomogram may help physicians provide individualized diagnosis and treatment for patients with gists following surgical resection.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;