syedzayyan/paper_mill_benchmark huggingface dataset:
Analysis of the Application Value of Different Esophagography Techniques in the Diagnosis of H-Type Tracheoesophageal Fistula in Neonates

The study aimed to analyse the detection rates of the triple-lumen double-balloon catheter technique and conventional esophagography in diagnosing h-type tracheoesophageal fistula (h-tef) in neonates.Methods.The data of 8 neonates diagnosed with h-tef by surgery in the researchers’ hospital between january 2015 and january 2022 were collected.We compared the detection (true positive) rates of h-tef by the triple-lumen double-balloon catheter technique, conventional esophagography, and multidetector row spiral ct.Results.Before surgery, conventional esophagography was applied in all 8 cases, of which the h-tef diagnosis was confirmed in 5 cases and tef was suspected in 3 cases.The triple-lumen double-balloon catheter technique was employed in 5 cases, of which 4 were confirmed with h-tef and 1 was suspected with tef.Multidetector row spiral ct was performed in 4 cases, and 1 case was confirmed with h-tef, while no fistula was observed in the other 3 cases.The triple-lumen double-balloon catheter technique yielded a 100% detection rate, while conventional esophagography revealed a 62.5% rate and multidetector row spiral ct showed a 25% rate.By comparative analysis, the true positive rates (tprs) of the triple-lumen double-balloon catheter technique and conventional esophagography were not significantly different ( p = 0.118 ).No significant differences were recorded in tprs between conventional esophagography and multidetector row spiral ct ( p = 0.221 ).However, the triple-lumen double-balloon catheter technique had a significantly higher tpr than multidetector row spiral ct ( p = 0.118 ).Conclusion.To diagnose congenital h-tef in neonates, conventional esophagography is a highly valuable yet inconsistently reliable method and the diagnostic value of ct is relatively limited.The triple-lumen double-balloon catheter technique boasts a significantly valuable application for h-tef diagnosis.Being simple, economical, and effective, it barely requires state-of-the-art facilities, and no complications have occurred during its clinical practice.These advantages justify a possible wider application of the triple-lumen double-balloon catheter technique in clinical practice.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Alcohol Extract of YFXJ Decoction Reverses the Drug Resistance of Human Lung Adenocarcinoma Cell Line A549/DDP

Lung cancer is the wide and common tumor.This study was designed to explore the effect of yfxj formula on non-small-cell lung cancer (nsclc) cell lines.Methods.Yfxj formula (mainly composed of astragalus membranaceus, atractylodes macrocephala, radix saposhnikoviae, radix glehniae, coix seed, herba sabina chinensis, hedyotis diffusa, pericarpium citri reticulatae, sarcophagus martensii, prunella vulgaris, meretrix meretrix, and oyster) was extracted with 75% ethanol.We performed mtt, facs, tunel, and mass spectrometry to study the effect of yfxj formula on a549/ddp cells.Results.The results showed that yfxj could inhibit the growth of a549/ddp cells, and it can reverse the sensitivity of a549/ddp cells to cisplatin.Yfxj inhibits the expression of mdr1, mrp1, and lrp genes in a549/ddp cells.Conclusion.Yfxj formula can reverse the drug resistance of a549/ddp cell, which could be through activation of autophagy.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Adverse Reaction of Acupuncture and Antihypertensive Drugs for Treatment of Essential hypertension: A Protocol for Bayesian Network Meta-Analysis

Hypertension, as a high risk factor of cardiovascular disease, has led to a significant upward trend in the population and incidence of the disease.Hypertension patients need to take antihypertensive drugs for life, and therefore people gradually pay more attention to the adverse reactions of antihypertensive drugs.This study protocol outlines a plan to assess the adverse reaction of the different antihypertensive drugs and acupuncture in order for clinical application.Objective.To compare the side effects of different antihypertensive drugs and acupuncture in the treatment of hypertension.Methods and analysis.We will search the databases containing cnki, wan-fang database, chinese scientific journal database(vip), pub med, cochrane, and embase, and randomized controlled trials (rcts) of commonly used antihypertensive drugs or acupuncture for primary hypertension will be obtained.Then, stata14.0 and gemtc will be used to assess the statistics.Ethics and dissemination.Since no personal patient consent will be required in the study, there is no ethical approval.The results of this reporting will be submitted to a peer-reviewed publication.Prospero registration number: crd42020152703.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Meta-Analysis;
ACE2 Promotes the Synthesis of Pulmonary Surfactant to Improve AT II Cell Injury via SIRT1/eNOS Pathway

We aimed to explore the level of ps, cell viability, inflammatory factors, and apoptosis in neonatal respiratory distress syndrome (ards).Besides, we explored the potential relationship between ace2, sirt1/e nos pathway, and hypoxia-induced at ii cell damage.Methods.The h uc-msc-derived at ii cells were verified by if and icc, whereas q rt-pcr was used for ps and at ii cell marker (ck-8 and kgf).The at ii cell damage model was established by hypoxia exposure.The enhanced expression of ace2 was tested after transfection with pc dna3.1-ace2 by western blot.The effects of hypoxia and ace2 on at ii cells were evaluated by mtt, western blot, elisa, and flow cytometry.The involvement of the sirt1/e nos pathway in at ii cell’s protective functions against nrds was verified with the addition of sirt1 inhibitor ex527.Results.Based on the successful differentiation of at ii cells from h uc-mscs and the buildup of at ii cell damage model, the overexpressed ace2 impeded the hypoxia-induced cellular damage of at ii cells.It also counteracted the inhibitory effects of hypoxia on the secretion of ps.Overexpression of ace2 rescued the cell viability and suppressed the secretion of inflammatory cytokines and the apoptosis of at ii cells triggered by hypoxia.And ace2 activated the sirt1/e nos pathway to play its cell-protective and anti-inflammatory roles.Conclusion.Our findings provided information that ace2 prevented at ii cells from inflammatory damage through activating the sirt1/e nos pathway, which suggested that ace2 might become a novel protective agent applied in the protection and treatment of nrds.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
A Comprehensive Nursing Model Combined with High-Quality Nursing Intervention for Antiviral Therapy in Patients with Chronic Hepatitis B

To investigate the effect of comprehensive nursing combined with high-quality nursing intervention on the compliance, anxiety, and mental state of patients with chronic hepatitis b undergoing antiviral therapy.Methods.A total of 100 patients with chronic hepatitis b admitted to china-japan union hospital from december 2017 to august 2020 were recruited and assigned to receive either routine nursing (control group, n = 50) or comprehensive nursing plus high-quality nursing (observation group, n = 50) via the random number table method.The outcome measures included compliance, psychological state, and treatment effects.Results.Before the nursing, there was no significant difference in the compliance scores between the two groups of patients p &gt; 0.05 .After the nursing, the observation group had higher compliance scores than the control group p &lt; 0.001 .Before the intervention, the two groups had similar self-rating anxiety scale (sas) scores p &gt; 0.05 .After the intervention, patients in the observation group showed lower sas scores and a lower incidence of negative emotions as compared to the control group p &lt; 0.001 .The observation group showed a better outcome in terms of quality of life, medical coping modes questionnaire (mcmq) scores, and the general self-efficacy scale (gses) scores when compared to those of the control group p &lt; 0.001 .A higher treatment effective rate was witnessed in the observation group in contrast to the control group p &lt; 0.001 .Conclusion.The comprehensive nursing model combined with high-quality nursing intervention improves the psychological state and compliance of patients with chronic hepatitis b, with favorable treatment efficiency, which shows good potential for clinical promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
A Case-Control Study of Continuous Veno-Venous Hemofiltration Combined with Xuebijing Injection in the Treatment of Severe Sepsis

A case‐control study was conducted to evaluate the efficacy of continuous veno‐venous hemofiltration (cvvh) combined with xuebijing in the treatment of severe sepsis.In order to verify this claim, this study included 100 patients with severe sepsis treated in our hospital from february 2019 to april 2021.The patients were randomly divided into control group and study group.The control group was treated with cvvh, and the study group was treated with cvvh combined with xuebijing.The curative effect and mortality, nt‐pro bnp, pct, ca∼_(2+), white blood cell count, neutrophil ratio, blood gas analysis, and apache‐ii score were compared between the two groups.The total effective rate of the study group was better than that of the control group ( p &lt; 0.05).The fatality rate in the study group was lower than that in the control group ( p &lt; 0.05).The levels of nt‐pro bnp and pct in the study group were lower than those in the control group, while the level of serum calcium in the study group was higher than that in the control group.After treatment, the white blood cell count (wbc) and neutrophil count in the study group were (13.76 ± 1.28) × 109 shock l and (73.48 ± 1.23)%, respectively, which were significantly lower than those in the control group (17.45 ± 1.36) × 109 shock l and (77.82 ± 1.44)% ( p &lt; 0.05).After treatment, the levels of aptt, pt, and dd in the study group were lower than those in the control group.The level of fib in the study group was significantly higher than that in the control group after treatment.After treatment, the pa o 2 and pa o 2 /fi o 2 of the study group were higher than those of the control group, and the apache‐ii score of the study group was lower than that of the control group.Cvvh combined with xuebijing is of positive significance in the treatment of severe sepsis and is worth popularizing.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
U-Net Modelling-Based Imaging MAP Score for Tl Stage Nephrectomy: An Exploratory Study

We evaluate the stability of the clinical application of the map scoring system based on anatomical features of renal tumour images, explore the relevance of this scoring system to the choice of surgical procedure for patients with limited renal tumours, and investigate the effectiveness of automated segmentation and reconstruction 3d models of renal tumour images based on u-net for interpretative cognitive navigation during laparoscopy tl stage radical renal tumour cancer surgery.A total of 5 000 kidney tumour images containing manual annotations were applied to the training set, and a stable and efficient full cnn algorithm model oriented to clinical needs was constructed to regionalism and multistructure and to finely automate segmentation of kidney tumour images, output modelling information in stl format, and apply a tablet computer to intraoperatively display the tl stage kidney tumour model for cognitive navigation.Based on a training sample of mr images from 201 patients with stage tl renal tumour cancer, an adaptation of the classical u-net allows individual segmentation of important structures such as renal tumours and 3d visualisation to visualise the structural relationships and the extent of tumour invasion at key surgical sites.The preoperative ct and clinical data of 225 patients with limited renal tumours treated surgically at our hospital from august 2011 to august 2012 were retrospectively analysed by three imaging physicians using the map scoring system for the total score and the variables r (maximum diameter), e (exogenous/endogenous), n (distance from the renal sinus), a (ventral/dorsal), l (relationship along the longitudinal axis of the kidney), and h (whether in contact with the renal hilum).The score for each variable (contact with the renal hilum) was statistically compared with each other for the three observers.Patients were divided into three groups according to the total score—low, medium, and high—and according to the surgical procedure—radical and partial resection.The correlation between the total score and the score of each variable and the choice of surgical procedure was analysed.The agreement rate of the total score and the score of each variable for all three observers was over 90% ( p ≤ 0.001).The map scoring system based on the anatomical features of renal tumour imaging was well stabilized, and the scores were significantly correlated with the surgical approach.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Ultrasonic Image Features under the Intelligent Algorithm in the Diagnosis of Severe Sepsis Complicated with Renal Injury

This research was aimed at analyzing the diagnosis of severe sepsis complicated with acute kidney injury (aki) by ultrasonic image information based on the artificial intelligence pulse-coupled neural network (pcnn) algorithm and at improving the diagnostic accuracy and efficiency of clinical severe sepsis complicated with aki.In this research, 50 patients with sepsis complicated with aki were collected as the observation group and 50 patients with sepsis as the control group.All patients underwent ultrasound examination.The clinical data of the two groups were collected, and the scores of acute physiology and chronic health assessment (apache ii) and sequential organ failure assessment (sofa) were compared.The ultrasonic image information enhancement algorithm based on artificial intelligence pcnn is constructed and simulated and is compared with the maximum between-class variance (ostu) algorithm and the maximum entropy algorithm.The results showed that the pcnn algorithm was superior to the ostu algorithm and maximum entropy algorithm in the segmentation results of severe sepsis combined with aki in terms of regional consistency (um), regional contrast (cm), and shape measure (sm).The acute physiology and chronic health evaluation (apache ii) and sequential organ failure assessment (sofa) scores in the observation group were substantially higher than those in the control group ( p &lt; 0.05 ).The interlobular artery resistance index (ri) in the observation group was substantially higher than that in the control group ( p &lt; 0.05 ).Moreover, the mean transit time (m tt) in the observation group was significantly higher than that in the control group ( 4.85 ± 1.27 vs.3.42 ± 1.04 ), and the perfusion index (pi) was significantly lower than that in the control group ( 134.46 ± 17.29 vs.168.37 ± 19.28 ), with statistical significance ( p &lt; 0.05 ).In summary, it can substantially increase ultrasonic image information based on the artificial intelligence pcnn algorithm.The ri, m tt, and pi of the renal interlobular artery level in ultrasound images can be used as indexes for the diagnosis of severe sepsis complicated with aki.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Total Saikosaponins Attenuates Depression-Like Behaviors Induced by Chronic Unpredictable Mild Stress in Rats by Regulating the PI3K/AKT/NF-iκ/iB Signaling Axis

Depression is a major cause of disability and most antidepressant medicines are ineffective owing to their high toxicity and numerous adverse effects.As a result, there is an urgent need to find new effective treatment methods.This paper aims to investigate the effect and mechanism of total saikosaponins (tss) on depression-like behaviors induced by chronic unpredictable mild stress (cums) in rats.Methods.Twenty-four male sd rats were randomly divided into 4 groups: control group, cums group, tss group, and fluoxetine (flu) group.Then, the following tests were conducted: sucrose preference test, open field test, and elevated plus maze test.Additionally, elisa was used to detect the levels of corticosterone (cort) and adrenocorticotropic hormone (acth) in the serum of the rats as well as the levels of inflammatory cytokines il-1β, il-6, and tnf-α in the hippocampus, and western blot was used for measuring the expression of brain-derived neurotrophic factor (bdnf) protein and related proteins of the pi3k/akt/nf-κb signaling pathway in the hippocampus.Results.Tss could significantly improve rat behaviors, specifically indicated by increases in sucrose preference, total movement distance, stay time in the central area, number of entries into open arms, time spent in open arms, and a decrease in stay time in the peripheral area.Tss acted to significantly reduce bdnf protein expression and increase the contents of acth and cort in serum as well as the levels of il-1β, il-6, and tnf-α in the hippocampal tissue in rats.In addition, it was able to raise the ratios of p-pi3k/pi3k and p-akt/akt and decrease the ratio of p-p65/p65 in tissues, which in turn regulated the pi3k/akt/nf-κb signaling pathway.Conclusions.Tss, through regulating pi3k/akt/nf-κb signaling axis, can alleviate depression-like behaviors and elevate neuroendocrine hormone levels and inflammatory factor levels.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
The Value of Artificial Intelligence Film Reading System Based on Deep Learning in the Diagnosis of Non-Small-Cell Lung Cancer and the Significance of Efficacy Monitoring: A Retrospective, Clinical, Nonrandomized, Controlled Study

To explore the value of artificial intelligence (ai) film reading system based on deep learning in the diagnosis of non-small-cell lung cancer (nsclc) and the significance of curative effect monitoring.Methods.We retrospectively selected 104 suspected nsclc cases from the self-built chest ct pulmonary nodule database in our hospital, and all of them were confirmed by pathological examination.The lung ct images of the selected patients were introduced into the ai reading system of pulmonary nodules, and the recording software automatically identified the nodules, and the results were compared with the results of the original image report.The nodules detected by the ai software and film readers were evaluated by two chest experts and recorded their size and characteristics.Comparison of calculation sensitivity, false positive rate evaluation of the nsclc software, and physician’s efficiency of nodule detection whether there was a significant difference between the two groups.Results.The sensitivity, specificity, accuracy, positive predictive rate, and false positive rate of nsclc diagnosed by radiologists were 72.94% (62/85), 92.06% (58/63), 81.08% (62+58/148), 92.53% (62/67), and 7.93% (5/63), respectively.The sensitivity, specificity, accuracy, positive prediction rate, and false positive rate of ai film reading system in the diagnosis of nsclc were 94.12% (80/85), 77.77% (49/63), 87.161% ( 80 + 49 /148), 85.11% (80/94), and 22.22% (14/63), respectively.Compared with radiologists, the sensitivity and false positive rate of artificial intelligence film reading system in the diagnosis of nsclc were higher ( p &lt; 0.05 ).The sensitivity, specificity, accuracy, positive prediction rate, and negative prediction rate of artificial intelligence film reading system in evaluating the efficacy of patients with nsclc were 87.50% (63/72), 69.23% (9/13), 84.70% ( 63 + 9 )/85, 94.02% (63/67), and 50% (9/18), respectively.Conclusion.The ai film reading system based on deep learning has higher sensitivity for the diagnosis of nsclc than radiologists and can be used as an auxiliary detection tool for doctors to screen for nsclc, but its false positive rate is relatively high.Attention should be paid to identification.Meanwhile, the ai film reading system based on deep learning also has a certain guiding significance for the diagnosis and treatment monitoring of nsclc.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Visualization Display System of Gannan Hakka Paper-Cut Works Based on Computer Graphics Algorithm

Today, computer graphics and graphic image processing techniques have been widely used in daily life and industrial production.Due to the development of computers, computer graphics has brought more convenience to our daily life.In order to give full play to the value of computers, this paper takes the hakka paper-cut art with local characteristics as the starting point, first of all its development history, artistic characteristics, compositional forms, expression techniques, cultural connotations, hakka paper-cut patterns, and the symbolic meaning of folk customs, and then we design a visualization system for the paper-cut works of gannan hakka based on computer graphics.In addition, the system provides a solution for the integration of gannan hakka paper-cut art and jiangxi native product packaging design and provides a reference for the theory and practice of modern native product packaging design.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
The Study of Maslow’s Hierarchy of Needs Theory in the Doctor-Nurse Integration Teaching Method on Clinical Interns

The student’s attitude towards the doctor-nurse integrated teaching model and maslow’s hierarchy of needs theory is an important topic in clinical teaching.In this study, choosing 134 intern doctors and practice nurses who intern from january to december 2020.67 students are selected as the control group, and the traditional interns teaching mode is adopted.67 students are selected as the experimental group and maslow’s hierarchy of needs theory to apply in the doctor-nurse integrated teaching mode.The results show that the doctor-nurse integrated teaching model are accepted by most students, and the application of maslow’s hierarchy of needs theory in the clinical interns has advantages over the traditional model.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;