syedzayyan/paper_mill_benchmark huggingface dataset:
Computational Biology Predicts the Efficacy of Tumor Immune Checkpoint Blockade

Tumor immunotherapy is considered as one of the most promising methods in cancer treatment in recent years.Immune checkpoint blockade (icb) can activate immune cells to destroy tumors by relieving the inhibitory pathway of tumor cells to immune cells.In silico prediction of the icb response is an important step toward achieving effective and personalized cancer immunotherapy.Although immune checkpoint inhibitors have shown exciting clinical effects in the treatment of many types of tumors, there are still some clinical problems in practical application, such as low response rate and large individualized differences.How to predict the efficacy of effective individualized immune checkpoint inhibitors for tumor patients based on specific biomarkers and computational models is one of the key issues in the immunotherapy of this kind of tumor.In our work, from the five levels of genome level, transcription level, epigenetic level, microbial taxonomy level, and the immune cell infiltration profile level, the biomarkers and in silico calculation methods that affect the efficacy of tumor immune checkpoint inhibitors are comprehensively summarized.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Development of Novel Nano-Silver-Based Antenna for Green Agriculture

The designed antenna is a monopole z‐shaped antenna operating in an unlicensed band of 2.4 ghz fabricated using low cost inkjet printing technology.The proposed inkjet printing technology is eco‐friendly since the material used here is an ordinary “paper” that is suitable for the green technology.The conducting patch of silver nanoparticle (ag np) ink has very high conductivity 35,700,000 s/m and instant curing property which helps in fabrication process without uv curing or oven heating.The printer used also is the cheap home printer hp dj 2130 rather than the expensive brother and epson printers used in previous works.The printed antenna will be helpful in conditions to ascertain its performance in green agriculture in the form of rf‐id sensors, soil p h value sensor, and moisture sensor.The proposed antenna attains the gain of 2.5 d bi at the ism band of 2.4 ghz with optimal vswr value between 1 and 2 over the desired frequency band.The directivity and radiation efficiency of the proposed antenna are 2 d bi and 80%, respectively.The overall cost of the proposed antenna is much lesser in the order of 10 times than the recent low cost design.

Journal: Advances in Materials Science and Engineering (2021)
Publication types: Research Article;
Creativity of Nanofiber Materials and Application in the Expressive Power of Manual Tie-Dyeing Process

Traditional printing and tie-dyeing are an important part of chinese handicrafts.It consists of three main techniques: batik, tie-dye, and multi-layer dyeing.Among the traditional printing and dyeing techniques, tie-dyeing creates an ever-changing visual artistic effect due to the diversity of its production methods.In modern society with the unprecedented development of technology and information, people’s life rhythm has accelerated, and the opposite “slow fashion” has become popular.More and more people are focusing more on the traditional craft of tie-dyeing.In contemporary fiber art, raw materials have become the soul and foundation of fiber art.This is also the difference between modern fiber art and traditional textile art.Entering the new era, the demand for textiles by people of all countries is also increasing, new functional requirements are put forward for textiles, and functional textiles emerge as the times require.The creative display of nanofibers is a comprehensive grasp of the properties of the fibrous material.It is the creativity and expression generated under the premise of understanding the type, shape, craft, and expression of fiber.It fully reflects the characteristics of the material itself, and it is also the designer’s ideological expression of the texture and shape of the material.It is then materialized into a certain connotation by appropriate technical means.In this paper, manual tie-dyeing is applied to nanofiber materials, making full use of the advantages of modern nanomaterials to promote the development of fabric tie-dyeing technology.In the performance test of the transmittance of nanomaterials to ultraviolet rays, it can be found that the transmittance of nanomaterials through the tie-dyeing process is lower for optical fibers with shorter wavelengths.When the wavelength of ultraviolet light is 313 nm, the transmittance of zn o to ultraviolet light is 0.When the ultraviolet wavelength is 435 nm, the transmittance of zn o to ultraviolet light is 45%.

Journal: Advances in Materials Science and Engineering (2022)
Publication types: Research Article;
Design and Reconstruction of Visual Art Based on Virtual Reality

Because traditional methods generally lack the image preprocessing link, the effect of visual image detail processing is not good.In order to enhance the image visual effect, a visual art design method based on virtual reality is proposed.Wavelet transform method is used to denoise the visual image and the noise signal in the image is removed; a binary model of fuzzy space vision fusion is established, the space of the visual image is planned, and the spatial distribution information of the visual image is obtained.According to the principle of light and shadow phenomenon in visual image rendering, the extend shadow map algorithm is used to render the visual image.Virtual reality technology was used to reconstruct the preprocessed visual image, and the ant colony algorithm was used to optimize the visual image to realize the visual image design.The results show that the peak signal-to-noise ratio of the visual image processed by the proposed method is high, and the image detail processing effect is better.

Journal: Security and Communication Networks (2021)
Publication types: Research Article;
Clinical Significance of Protective Motivation Intervention Nursing on Functional Recovery of Patients after Hip Arthroplasty

To explore the clinical significance of protective motivation intervention nursing on functional recovery of patients after hip arthroplasty.Methods .Sixty patients after hip arthroplasty treated in our hospital from february 2019 to april 2021 were selected.The patients were randomly divided into the control group and the research group.The routine nursing mode was adopted in the control group, and the protective motivation intervention nursing mode was adopted in the research group.Nursing satisfaction, fim score, harris hip function score, womac score, barthel index score, and quality of life score were compared between the two groups.Results .The nursing satisfaction of the research group was higher than that of the control group, and there are statistically significant differences between the groups ( p &lt; 0.05).The fim scores of the research group at discharge and 1 month, 3 months, and 6 months after discharge were significantly higher than those in the control group.The harris hip function score of the research group was significantly higher than that of the control group at discharge and 1 month, 3 months, and 6 months after discharge.The womac scores of the research group at discharge and 1 month, 3 months, and 6 months after discharge were significantly lower than those in the control group, and the difference was statistically significant ( p &lt; 0.05).The scores of the barthel index at discharge and 1 month, 3 months, and 6 months after discharge in the research group were significantly higher than those in the control group.The scores of physiological function, psychological function, social function, and health self‐cognition in the research group were significantly lower than those in the control group, and the difference was statistically significant ( p &lt; 0.05).Conclusion .The nursing model of protective motivation intervention for patients after hip arthroplasty can effectively improve the function of hip joint, improve the quality of life, promote the establishment of harmonious nurse‐patient relationship, and play a positive role in improving the prognosis of patients.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Clinical Efficacy of Laparoscopic-Assisted Proximal Gastrectomy with Postoperative Double-Channel Digestive Tract Reconstruction: A Case-Control Analysis

To investigate the clinical effect of laparoscopic‐assisted proximal gastrectomy with postoperative double‐channel digestive tract reconstruction.Methods .A total of 40 patients with proximal gastric cancer who underwent gastrectomy in zhujiang hospital, southern medical university, were selected to collect relevant clinical data.They were divided into two groups according to their treatment methods: tg‐ry group (total gastrectomy with roux‐en‐y reconstruction group) and pg‐dt group (proximal gastrectomy with double tract reconstruction group).The general data, perioperative indicators, nutritional indicators, and postoperative complications of the two groups were analyzed and compared.Results .There was no statistical significance in the comparison of general data between the two groups, but the proportion of iii stage patients of tnm stage in the pg‐dt group was larger than that in the tg‐ry group.Meanwhile, the intraoperative blood loss, postoperative hospital stay, and first exhaust time in pg‐dt group were lower than those in tg‐ry group ( p &lt; 0.05).After surgery, the nutritional indexes of the pg‐dt group decreased, and the decrease degree was less than that of the tg‐ry group, while the infection indicators of the pg‐dt group increased less than that of the tg‐ry group.Statistical analysis of postoperative complications showed that the total incidence of pg‐dt group was lower than that of tg‐ry group.Conclusion .Proximal gastric cancer resection and postoperative dtr anastomosis can effectively speed up the recovery of patients and reduce the incidence of postoperative complications, with good efficacy.This experiment provides evidence for the advantages of various postoperative anastomosis methods and also provides a reliable basis for clinicians’ diagnosis and treatment, thus effectively improving patients’ postoperative quality of life.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Clinical Application of Thoracoscopic Resection of Anterior Mediastinal Tumors under the Xiphoid Process

To explore the feasibility and advantages of thoracoscopic resection of anterior mediastinal tumors through subxiphoid and lateral thoracic approaches.Method .74 patients with anterior mediastinal tumors hospitalized in our hospital from january 2019 to january 2022 were retrospectively analyzed.They were divided into the lateral chest group (31 cases) and the infraxiphoid group (43 cases) according to different operation methods.The tumor size, operation time, intraoperative bleeding, postoperative pain score, postoperative complications, postoperative drainage tube removal time, and hospital stay were compared between the two groups.Result .The intraoperative bleeding and postoperative pain scores in the subxiphoid group were better than those in the lateral chest group.There was no significant difference in operation time and postoperative complications between the two groups.Conclusion .Compared with the lateral thoracic approach, the thoracoscopic subxiphoid approach can be more safe and effective in resectioning anterior mediastinal tumors.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Chinese Herb Jiedu Huayu Granules Inhibiting Immune and Inflammatory Response of Rats with Acute Liver Failure by Regulating the NF-iκ/iB Signaling Pathway

To research the influence of chinese medicine jiedu huayu granules (jdhy) on the immune response and inflammatory response of rats with acute liver failure (alf) and investigate its related mechanism.Methods .Rats were randomly divided into 4 groups: control group ( n = 6) were injected with the same amount of normal saline; alf group ( n = 10) were injected intraperitoneally with d‐ga in (700 mg/kg) and lps (10 μ g/kg); alf+jdhy group ( n = 10) were given jdhy 57.55 g/kg/d by gavage for 7 days and injected intraperitoneally with d‐ga in/lps after the last dose; and alf+bay group ( n = 10) were given bay 10 mg/kg/d by gavage for 7 days and injected intraperitoneally with d‐ga in/lps after the last dose.Changes in liver function and coagulation function were examined in rat serum; the pathological varieties of liver tissues were verified by he staining; immunohistochemistry was utilized to determine the ratio of pcna and f4/80 in liver tissues; the flow cytometry was applied to determine the ratio of cd4+/cd8+ cells in peripheral blood mononuclear cells (pbmcs); elisa and q rt‐pcr were utilized to check the level of il‐10, il‐6, il‐13, il‐1 β , tnf‐ α , ifn‐ γ , and cd163 in serum and liver cells.Western blot was adopted to check the expression of apoptotic protein and expression and nf‐ κ b pathway‐related protein expression.Results .Jdhy and bay could decline the expression of ast, alt, alp, and tbi l in alf rat serum significantly ( p &lt; 0.01), increase pta and plt ( p &lt; 0.01), and mitigate liver tissue damage.Besides, jdhy and bay could reduce the apoptosis and improve the proliferation of the liver cells in rats with alf; meanwhile, the ratio of cd4+ cells and f4/80 cells was reduced while cd8+ cells were increased ( p &lt; 0.01).Further, jdhy and bay could reduce the level of ifn‐ γ , il‐6, il‐1 β , and tnf‐ α while increasing the level of il‐10 and il‐13 ( p &lt; 0.01).Additionally, the expression of s cd163 in serum and cd163 expression in liver tissues increased ( p &lt; 0.01).The result of western blot confirmed that jdhy could inhibit the phosphorylated expression of nf‐ κ b, ik βα , and ikk β in the alf rat tissues.Conclusions .Jdhy can upregulate the level of cd163/s cd163 by the nf‐ κ b signaling pathway, thereby regulating immune response, inhibiting inflammatory response, and ultimately improving alf in the rats.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Changes in Pre- and Postsurgery for Drug Resistant Epilepsy: Cognition and Sleep

Most patients with drug‐resistant epilepsy (dre) have cognitive impairment and sleep disturbance.There was a significant correlation between sleep disorders and cognitive dysfunction.This study performed surgical treatment on patients with dre and observed seizures, sleep, and cognition in patients with dre in 6th month after operation to clarify the correlation between sleep and cognition in dre patients.Methods .21 individuals with dre were recruited to enroll in this trial.Each participant completed epileptic focus resection.Seizure frequency was the principle index; the mean seizure frequency was 1 month before surgery and six months after surgery.Cognitive function was assessed by mmse, and sleep status was assessed by psqi and acti graph; assessments were performed before and 6 months after surgery.Results .There were significant differences between conditions on all outcome measures; after 6 months of surgery, compared with before treatment, the monthly average seizure frequency of dre decreased, which was statistically significant ( p &lt; 0.001) compared with that before treatment.The mmse score of dre patients was significantly higher than before ( p &lt; 0.01), especially the ability of attention, calculation, and recall in mmse score, which was significantly higher than before operation (respectively, p &lt; 0.001 and p &lt; 0.01).The subjective sleep evaluation index psqi and objective measurement of sleep latency, total sleep time, and sleep efficiency of patients with dre by acti graph were statistically significant (respectively, p &lt; 0.01) compared with that before treatment.There was a correlation between seizure frequency and mmse ( r = −0.8887, p &lt; 0.0001), psqi (0.5515, p &lt; 0.01), sleep latency (0.5353, p &lt; 0.05), total sleep time (‐0.7814, p &lt; 0.0001), and sleep efficiency (‐0.4380, p &lt; 0.05).Conclusions .Surgery can effectively reduce the epileptic seizures frequency in patients with dre and indirectly improve the computational power, attention, recall ability, and sleep status of patients.However, this result did not show a correlation between improved cognitive function and sleep, so the patient’s cognitive function may be caused by surgery to improve the frequency of seizures.So, whether the improvement of patients’ sleep conditions can also significantly improve the frequency of attacks and cognitive function in patients with dre needs further exploration.

Journal: BioMed Research International (2022)
Publication types: Research Article;
CD73 (NT5E) Promotes the Proliferation and Metastasis of Lung Adenocarcinoma through the EGFR/AKT/mTOR Pathway

Introduction .Lung cancer is the most common malignant tumor and the main cause of tumor‐related death globally.As the 5‐year survival rate of lung adenocarcinoma (luad) remains low, it is necessary to investigate novel molecular markers and therapeutic targets for luad.Materials and methods .The protein expression of cd73 (nt5e) in luad specimens was analyzed using immunohistochemistry.Reverse transcription‐quantitative pcr and western blot analysis were used to analyze the m rna and protein expression levels of several genes in luad cells.The proliferation of luad cells was evaluated using proliferation and colony formation assays and apoptosis analysis.Wound healing and transwell invasion assays were used to analyze the migration and invasion of the a549 cells, respectively.In addition, overexpression plasmids and small interfering rnas were used to overexpress or knockdown the expression levels of cd73 in the a549 cell line, respectively.Finally, the interaction between cd73 and egfr in the a549 cell line was analyzed using immunoprecipitation.Results .Our research emphasized the importance of cd73 in the prognosis of luad and highlighted it as a potential therapeutic target.We also found that the m rna and protein expression levels of cd73 are increased in luad specimens and cell lines and were associated with a poor prognosis in patients with luad.Furthermore, it was revealed that cd73 may promote the proliferation, migration, and invasion of the a549 cell line.Finally, we demonstrated that cd73 could bind epidermal growth factor receptor (egfr) to further regulate the activation of the akt/m tor signaling pathway.Conclusions .Cd73 promotes luad proliferation and metastasis through egfr/akt/m tor axis.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Building a Cross-Border E-Commerce Ecosystem Model Based on Block Chain + Internet of Things

With the development of internet technology, cross-border e-commerce in the form of “internet + foreign trade” has come into being.However, in recent years, scholars have continuously raised the problem that the cross-border e-commerce ecosystem with cross-border e-commerce platform as the core and the new internet technology has not been developed sympathetically.Therefore, by establishing a model of cross-border e-commerce ecosystem and new internet technology (block chain + internet of things), this paper analyzes the stable evolution strategy of both for convergence development and proposes countermeasures for the convergence development of new internet technology and cross-border e-commerce platform ecosystem of rfid technology logistics tracking + block chain authentic product traceability, taking vertical class cross-border e-commerce platform as an example.The simulation experiment results show that the solution proposed in this paper is feasible compared with traditional and has obvious advantages in data theft prevention, multiparty authentication, and saving system overhead to solve the calculation method of e-commerce sharing problem.Reference is provided for solving the e-commerce cyberculture problem.The process takes advantage of block chain decentralization and auditability from the relevant data analysis from the theoretical concept of big data, the current situation of cross-border e-commerce, and how big data can be applied and developed for cross-border e-commerce, in three major dimensions.

Journal: Security and Communication Networks (2021)
Publication types: Research Article;
Berberine Attenuates IL-1β-Induced Damage of Nucleus Pulposus Cells via Activating the AMPK/mTOR/Ulk1 Pathway

Intervertebral disc degeneration (idd) is a chronic progressive condition mainly caused by excessive inflammatory cytokines.Berberine (bbr) exerts anti‐inflammatory effect on diseases and protective effect against idd.However, the mechanism is not uncertain.This study is aimed at investigating the molecular mechanism of bbr on idd.Nucleus pulposus (np) cells were treated with bbr at different concentrations.The idd rat model was established by acupuncture.The effect of bbr on interleukin‐ (il‐) 1 β ‐induced cell proliferation was measured by cck‐8 assay and brd u staining.The role of bbr in il‐1 β ‐induced apoptosis, autophagy repression, and extracellular matrix (ecm) degradation was measured by annexin/pi staining, immunofluorescence, and immunoblot.The effect of bbr on idd was investigated in rat.Our findings showed that bbr restored cell growth and attenuated apoptosis in il‐1 β ‐induced np cells.Bbr also prevented the il‐1 β ‐induced ecm degradation through regulating ecm‐related enzymes and factors.Additionally, bbr significantly activated autophagy repressed by il‐1 β .Autophagy stimulated by bbr was diminished by the inhibition of the ampk/m tor/ulk1 signaling pathway.In vivo study also showed bbr attenuated intervertebral disc degeneration.Bbr could attenuate np cells apoptosis and ecm degradation induced by il‐1 β through autophagy by the ampk/m tor/ulk1 pathway.This study suggests bbr might function as an ampk activator to alleviate idd progression.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Automatic Segmentation of MRI of Brain Tumor Using Deep Convolutional Network

Computer‐aided diagnosis and treatment of multimodal magnetic resonance imaging (mri) brain tumor image segmentation has always been a hot and significant topic in the field of medical image processing.Multimodal mri brain tumor image segmentation utilizes the characteristics of each modal in the mri image to segment the entire tumor and tumor core area and enhanced them from normal brain tissues.However, the grayscale similarity between brain tissues in various mri images is very immense making it difficult to deal with the segmentation of multimodal mri brain tumor images through traditional algorithms.Therefore, we employ the deep learning method as a tool to make full use of the complementary feature information between the multimodalities and instigate the following research: (i) build a network model suitable for brain tumor segmentation tasks based on the fully convolutional neural network framework and (ii) adopting an end‐to‐end training method, using two‐dimensional slices of mri images as network input data.The problem of unbalanced categories in various brain tumor image data is overcome by introducing the dice loss function into the network to calculate the network training loss; at the same time, parallel dice loss is proposed to further improve the substructure segmentation effect.We proposed a cascaded network model based on a fully convolutional neural network to improve the tumor core area and enhance the segmentation accuracy of the tumor area and achieve good prediction results for the substructure segmentation on the bra ts 2017 data set.

Journal: BioMed Research International (2022)
Publication types: Research Article;