syedzayyan/paper_mill_benchmark huggingface dataset:
Microstructure and Corrosion Behavior of Iron Based Biocomposites Prepared by Laser Additive Manufacturing.

Iron (fe) has attracted great attention as bone repair material owing to its favorable biocompatibility and mechanical properties.However, it degrades too slowly since the corrosion product layer prohibits the contact between the fe matrix and body fluid.In this work, zinc sulfide (zn s) was introduced into fe bone implant manufactured using laser additive manufacturing technique.The incorporated zn s underwent a disproportionation reaction and formed s-containing species, which was able to change the film properties including the semiconductivity, doping concentration, and film dissolution.As a result, it promoted the collapse of the passive film and accelerated the degradation rate of fe matrix.Immersion tests proved that the fe matrix experienced severe pitting corrosion with heavy corrosion product.Besides, the in vitro cell testing showed that fe/zn s possessed acceptable cell viabilities.This work indicated that fe/zn s biocomposite acted as a promising candidate for bone repair material.

Journal: Micromachines (2022)
Publication types: Journal Article
Glutamate inputs from the laterodorsal tegmental nucleus to the ventral tegmental area are essential for the induction of cocaine sensitization in male mice.

Rationale drug-induced potentiation of ventral tegmental area (vta) glutamate signaling contributes critically to the induction of sensitization - an enhancement in responding to a drug following exposure which is thought to reflect neural changes underlying drug addiction.The laterodorsal tegmental nucleus (ldtg) provides one of several sources of glutamate input to the vta.Objective we used optogenetic techniques to test either the role of ldtg glutamate cells or their vta afferents in the development of cocaine sensitization in male vglu t2::cre mice.These were inhibited using halorhodopsin during each of five daily cocaine exposure injections.The expression of locomotor sensitization was assessed following a cocaine challenge injection 1-week later.Results the locomotor sensitization seen in control mice was absent in male mice subjected to inhibition of ldtg-vta glutamatergic circuitry during cocaine exposure.As sensitization of nucleus accumbens (nacc) dopamine (da) overflow is also induced by this drug exposure regimen, we used microdialysis to measure nacc da overflow on the test for sensitization.Consistent with the locomotor sensitization results, inhibition of ldtg glutamate afferents to the vta during cocaine exposure prevented the sensitization of nacc da overflow observed in control mice.Conclusions these data identify the ldtg as the source of vta glutamate critical for the development of cocaine sensitization in male mice.Accordingly, the ldtg may give rise to the synapses in the vta at which glutamatergic plasticity, known to contribute to the enhancement of addictive behaviors, occurs.

Journal: Psychopharmacology (2022)
Publication types: Journal Article
Response surface model comparison and combinations for remifentanil and propofol in describing response to esophageal instrumentation and adverse respiratory events.

The primary aim of this essay was to explore the best fitting model in remifentanil-propofol combined administrations during esophageal instrumentation (ei) from five distinct response surface models.The secondary aim was to combine the models to give appropriate effect-site drug concentrations (ces) range with maximal comfort and safety.Methods the greco, reduced greco, minto, scaled c50 hierarchy and fixed c50 hierarchy models were constructed to fit four drug effects: loss of response to esophageal instrumentation (lrei), loss of response to esophageal instrumentation revised (lreir), intolerable ventilatory depression (ivd) and respiratory compromise (rc).Models were tested by chi-square statistical test and evaluated with akaike information criterion (aic).Model prediction performance were measured by successful prediction rate (spr) and three prediction errors.Results the reduced greco model was the best fitting model for lrei and rc, and the minto model was the best fitting model for lreir and ivd.The sprs of reduced greco model for lrei and rc were 81.76% and 79.81%.The sprs of minto model for lreir and ivd were 80.32% and 80.12%.Overlay of the reduced greco model for lrei and minto model for ivd offered visual aid for guidance in drug administration.Conclusion using proper response surface model to fit different drug effects will describe the interactions between anesthetic drugs better.Combining response surface models to select the more reliable effect-site drug concentrations range can be used to guide clinical drug administration with greater safety and provide an improvement of anesthesia precision.

Journal: Journal of the Formosan Medical Association = Taiwan yi zhi (2022)
Publication types: Journal Article
Sexual and reproductive health service utilization of young girls in rural Ethiopia: What are the roles of health extension workers? Community-based cross-sectional study.

Little is known about the extent to which health extension programme (hep) has played its role to increase service uptake among young girls.This study aims to estimate the status of young girls' sexual and reproductive health (srh) services utilisation in rural ethiopia and to examine the role of health extension workers (hews) in this regard.Design a cross-sectional study.Setting a community-based study among all nine regions of ethiopia.Participants nine hundred and two young girls aged 15-24 years were included in this study.Method we used data from the national hep assessment, collected from march to may 2019.Multilevel binary logistic regression was used to investigate the association between exposure to hep and srh services utilisation of young girls and we reported an adjusted or with a corresponding 95% ci as measure of the degree of associations.Result only 19.18% (95% ci 16.74% to 21.89%) of young girls used srh services with significant regional variability (intraclass correlation coefficien=17.16%; 95% ci 6.30% to 39.99%).Exposure to hep (adjusted or, a or 3.13, 95% ci 2.03 to 4.85), knowing about the availability of hep services (a or 3.06, 95% ci 1.75 to 5.33) and having good trust in hews (a or 1.82, 95% ci 1.07 to 3.10) and other sociodemographic factors were significantly associated with increased srh services utilisation.Outcome srh service utilisation.Conclusion although the overall srh service utilization of young girls in rural ethiopia was very low, hews have a great contribution to improving service utilization of young girls through strong health education provided during home visits, school visits and at health posts.More investment along this line has the potential to improve service uptake among young girls.Encouraging hews to build trust among this segment of the population and creating awareness of srh-related services is crucial to improv service uptake.

Journal: BMJ open (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Relationship Between Negative Mood and Health Behaviors in an Immigrant and Refugee Population.

Immigrants experience an escalation of negative health behaviors after arrival to the united states.Negative mood is associated with poorer health behaviors in the general population; however, this relationship is understudied in immigrant populations.Adolescent (n = 81) and adult (n = 70) participants completed a health behavior survey for immigrant families using a community-based participatory research approach.Data was collected for mood, nutrition, and physical activity.Adolescents with positive mood drank less regular soda, and demonstrated more minutes, higher levels, and greater social support for physical activity (all ps < .05).Adults with positive mood reported more snacking on fruits/vegetables, greater self-efficacy for physical activity, and better physical well-being (all ps < .05).Negative mood was associated with low physical activity level and poor nutritional habits in adolescent and adult immigrants.Designing community-based programs offering strategies for mood management and healthy lifestyle change may be efficacious for immigrant populations.

Journal: Journal of immigrant and minority health (2017)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Characterization and comparison of the bacterial community on environmental surfaces through a fresh-cut vegetables processing line in China.

Zoning is typically adopted by food manufacturers and classified into three different zones including zone 1 (food contact surface), zone 2 (proximity to food and food contact surfaces) and zone 3 (remote surfaces from processing).In this study, environmental surfaces belonging to these three zones were sampled during food processing in a fresh-cut vegetables (fvs) processing facility located in beijing, china.Bacterial loads in terms of aerobic plate count and coliform count were evaluated by culture-dependent techniques.The profile and diversity of bacterial community in these three zones were investigated by high-throughput sequencing.Zone 1 showed similar microbiota and predominated by pseudomonas and acinetobacter, while the predominant genera on zone 2 or 3 were quite varied among different processing steps.The source tracker analysis showed that most of the bacteria (above 80%) on surfaces were from unknown sources, while sorting and disinfection & cleaning steps contributed equally to the bacterial community of cutting areas.Microbial association network analysis revealed strong positive interactions of comamonas and janthinobacterium with myroides and serratia, respectively, whereas pseudomonas showed no significant correlation with other genera.The function of microbial communities was predicted based on bug base 16s r rna database, and the results indicated that the proportions of potential biofilm-forming bacteria were above 70% in all samples, and species of pseudomonas, comamonas, chryseobacterium and janthinobacterium were opportunistic pathogens or spoilage bacteria.This study evaluated the bacteria risks including bacterial load, composition, as well as potential bacterial interaction, function and microbial transfer on food processing surfaces, which will facilitate our better understanding on the cross-contaminations and preventions of harmful microorganism in fvs processing industry.

Journal: Food research international (Ottawa, Ont.) (2022)
Publication types: Journal Article
Long-term results of the modified Konno procedure in high-risk children with obstructive hypertrophic cardiomyopathy.

Transaortic septal myectomy is the gold standard surgery in obstructive hypertrophic cardiomyopathy, but it is not optimal for children aged less than 5 years and with right ventricular outflow tract obstruction.We evaluated outcomes with the modified konno procedure in children with severe forms of obstructive hypertrophic cardiomyopathy.Methods a total of 79 consecutive children who underwent the modified konno procedure in our center between 1991 and 2016 were included.Results clinical features included age less than 5 years (38%), maximal septal thickness 25 mm or more (32%), extension to the left ventricular apex (29%), and right ventricular outflow tract obstruction (28%).In total, 25% of patients had noonan syndrome.Five children (6%) aged less than 15 months with noonan syndrome and biventricular obstruction died in the hospital.Mean follow-up was 6 ± 5.7 years.Survival without death and heart transplantation was 82% at 20 years.Atrioventricular block occurred in 9 patients (11%) and was associated with right ventricular outflow tract obstruction and surgery before 2010.Death, resuscitated sudden cardiac death, and appropriate implantable defibrillator shock were associated with maximal septal thickness before surgery (adjusted odds ratio, 1.20; 95% confidence interval, 1.07-1.35; p = .002) and need for an associated procedure (adjusted odds ratio, 8.84; 95% confidence interval, 2.01-38.93; p = .004).There was no case of recurrent obstruction.Reoperation was required in 4 patients (5%) for other reasons.Conclusions the modified konno procedure provided durable obstruction relief and good long-term survival in children with severe forms of obstructive hypertrophic cardiomyopathy.Children with noonan syndrome undergoing surgery early in life were at higher risk of early mortality.

Journal: The Journal of thoracic and cardiovascular surgery (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Video-Audio Media
The roles of CyPA and CD147 in cardiac remodelling.

Cyclophilin a (cy pa), an abundantly expressed protein belonging to the immunophilin family, is involved in a variety of physiological and pathological activities together with its extracellular receptor, cd147.Many studies have provided compelling evidence supporting critical roles of cy pa in immune and infectious diseases and malignant tumours.Recent studies have revealed that both cy pa and cd147 strongly promote cardiovascular inflammation, myocardial ischaemia-reperfusion injury, and myocardial remodelling processes.Here, we review the potential roles of cy pa and cd147 in cardiac remodelling and their implications for the development of novel pharmacological therapies for heart failure.

Journal: Experimental and molecular pathology (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Co-regulation and parenting stress over time in full-term, very low birthweight preterm, and psycho-socially at-risk infant-mother dyads: Implications for fostering the development of healthy relationships.

From birth, mothers and infants co-regulate their interactions that are shaped by their socio-emotional development, relationship history, current circumstances, and goals.However, few studies have longitudinally explored co-regulation in the context of medical and psycho-social risk.The present 4-wave longitudinal study sought to shed light on factors associated with co-regulation over time in infants from 6- to 48-months.The objectives were to 1) identify differences in co-regulation among low- and at-risk infant-mother dyads, 2) explore changes in co-regulation over time, and 3) explore the associations between infant-mother co-regulation and parenting stress in these low- and at-risk groups over time.Participants included three groups of infant-mother dyads (full-term [ft], n = 48; very low birthweight/preterm [vlbw/preterm] born 26-32 weeks, weighing 800-1500 g, n = 61; psycho-socially at-risk where parents had histories of socioeconomic disadvantage, n = 54) followed longitudinally at 6-, 12-, 18-, and 48-months of age.Dyads engaged in a free play in their homes that was coded for co-regulation using fogel, de koeyer, secrist, sipherd, hafen, and fricke's (2003) revised relational coding system (rrcs), and mothers reported on their level of parenting stress.Results from manovas at each time point indicated significant differences between the groups at 18-months, with psycho-socially at-risk dyads engaging in more one-sided interactions than ft and vlbw/preterm dyads, and more dysregulation and miscommunication than vlbw/preterm dyads.Multi-level models of co-regulation revealed that dyads became progressively less synchronous from 6- to 12-months, followed by greater synchrony and mutual reciprocity from 12-months onwards.Parenting stress was associated with less synchrony and less mutual reciprocity amongst the at-risk groups.Maternal education was associated with greater engagement and girls tended to engage in more synchronous interactions than boys.Our results underscore the value and implications of considering background risk and concurrent parent perceptions in the development and reciprocity of parent-infant co-regulation and their subsequent relationships from infancy onwards.

Journal: Infant behavior & development (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Response to Immunosuppressive Therapy in Acquired Aplastic Anaemia: Experience of a Tertiary Care Centre from Eastern India.

The current study was conducted to assess response to immunosuppressive therapy (ist) in acquired aplastic anaemia (aa).It was a retrospective and prospective observational study.Patients were diagnosed as per standard international guidelines and ist was started as per standard protocol.Patients were followed up at 3 months and 6 months for assessment of response as per published standard guidelines.Total 76 cases were included in the study.The median age of the study population was 36 years with a range of 6-66 years with a male to female ratio of 2.04:1.Most common clinical presentation was pallor followed by bleeding.Commonest type of disease in the study group was severe aa.Among total 76 patients, 32 patients received atgam and 44 patients received thymogam.Within 3 months of atg administration, 4 patients died and 1 patient was lost to follow up.At 3 months, 2 (2.63%) patients were on complete response (cr), 32 (42.10%) patients were in partial response (pr) and 37 (48.68%) patients were on no response (nr).Overall response (or) at 3 months was 44.73%.At 6 months 5 (6.57%) patients were in cr, 43 (56.57%) patients in pr and 23 (30.26%) patients in nr; the or was 63.14%.Overall response at 3 months was 44.73% and overall response at 6 months was 63.14%.The study revealed better overall survival for patients with atgam treatment than thymogam treatment arm.

Journal: Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion (2021)
Publication types: Journal Article
Self-reported taste and smell alterations and the liking of oral nutritional supplements with sensory-adapted flavors in cancer patients receiving systemic antitumor treatment.

Taste and smell alterations (tas and sas) are often reported by patients with cancer receiving systemic antitumor therapy and can negatively impact food intake and quality of life.This study aimed to examine the occurrence of tas and sas and investigate the impact of tas on overall liking of oral nutritional supplements (ons) with warming and cooling sensations.Methods patients receiving systemic antitumor therapy completed a questionnaire on sensory alterations and evaluated overall liking of 5 prototype flavors of nutridrink® compact protein (hot tropical ginger (htg), hot mango (hm), cool red fruits (crf), cool lemon (cl), and neutral (n)) on a 10-point scale via a sip test.Differences between patients with and without tas were investigated using permutation analysis.Results fifty patients with various cancer types and treatments were included.Thirty patients (60%) reported tas and 13 (26%) experienced sas.Three flavors were rated highly with a liking score > 6 (crf 6.8 ± 1.7; n 6.5 ± 1.9; htg 6.0 ± 2.0).Larger variation in ons liking scores was observed in patients with tas with or without sas (4.5-6.9 and 4.6-7.2, respectively) vs.Patients without tas (5.9-6.5).Tas were associated with increased liking of crf (δ = + 0.9) and n (δ = + 1.0) flavors.Conclusions tas and sas are common in patients with cancer undergoing systemic antitumor therapy.Patients with tas were more discriminant in liking of ons flavors compared to patients without tas, and sensory-adapted flavors appeared to be appreciated.The presence of tas should be considered when developing or selecting ons for patients with cancer.Trial registration registration at clinical trials.gov (nct03525236) on 26 april 2018.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2021)
Publication types: Journal Article
The association between health expenditure, institutions, and economic growth in MENA countries.

Expenditure on health is vital in the development of a country.Furthermore, the current covid-19 pandemic emphasises the importance of health investments in maintaining a healthier economy worldwide.A substantial amount of empirical research on the relationship between health expenditure and economic growth yields conflicting results.The study intends to investigate the relationship between health spending and economic growth and institutions' role in causing health spending to promote growth.methods:the study uses longitudinal data to examine the relationship between health spending and economic growth in seven mena countries from 2000 to 2017.The study uses the phillips perron (pp) fisher chi-square stationarity test, indicating that the data series is not stationary.Following this, we used the pedroni test for cointegration, and the results show long-run relationships between the variables.Next, granger causality determines the direction of causality.Finally, panel data methods of panel ordinary least squares (panel ols), fully modified ols (fmols), and dynamic ols (dlos) supplement the findings.results:the pedroni cointegration test (pvalue<0.0001) indicates that the variables have a long-run cointegrating relationship.On the other hand, the granger causality test finds no causal relationships between health spending and economic growth.Furthermore, the panel data models show that expenditure on health does not directly contribute to higher economic growth in mena countries.conclusion:the findings of this study indicate that health spending does not lead to increased economic growth; this could be due to poor institutional quality.However, for health spending to positively impact economic growth, these investments in health care must be supplemented by other factors, particularly institutions.

Journal: Health promotion perspectives (2022)
Publication types: Journal Article
Systematic Review and Meta-Analysis on Colorectal Anastomotic Techniques.

Anastomosis creation after resective gastrointestinal surgery is a crucial task.The present review examines the techniques and implants currently available for anastomosis creation and analyses to which extent they already address our clinical needs, with a special focus on their potential to enable further trauma minimization in visceral surgery.Methods a multi-database research was conducted in medline, scopus, and cochrane library.Comparative controlled and uncontrolled clinical trials dealing with anastomosis creation techniques in the intestinal tract in both german and english were included and statistically significant differences in postoperative complication incidences were assessed using the rev man5.4 review manager (cochrane collaboration, oxford, uk).Results all methods and implant types were analyzed and compared with respect to four dimensions, assessing the techniques' current performances and further potentials for surgical trauma reduction.Postoperative outcome measures, such as leakage, stenosis, reoperation and mortality rates, as well as the tendency to cause bleeding, wound infections, abscesses, anastomotic hemorrhages, pulmonary embolisms, and fistulas were assessed, revealing the only statistically significant superiority of hand-suture over stapling anastomoses with respect to the occurrence of obstructions.Conclusion based on the overall complication rates, it is concluded that none of the anastomosis systems addresses the demands of operative trauma minimization sufficiently yet.Major problems are furthermore either low standardization potentials due to dependence on the surgeons' levels of experience, high force application requirements for the actual anastomosis creation, or large and rigid device designs interfering with flexibility demands and size restrictions of the body's natural access routes.There is still a need for innovative technologies, especially with regard to enabling incisionless interventions.

Journal: Therapeutics and clinical risk management (2022)
Publication types: Journal Article;Review