syedzayyan/paper_mill_benchmark huggingface dataset:
A universal method of chaos cascade and its applications.

This paper proposes a universal method for a cascade chaotic system (ccs).Ccss may own better performances, including larger maximum lyapunov exponents, extended full mapping range of chaos, and more coefficient variations.The chaos-cascade theorems had been proposed in our previous papers, which are more suitable for discrete chaotic systems with the same domain.In this paper, we further improve a universal method to normalize arbitrary discrete chaotic systems for constructing a series of ccss.Besides, the inheritance and enhancement of robustness from the subsystem are first explored for ccss.Finally, the designed ccs is implemented on field programmable gate array board.The generated chaotic sequences are obtained by an oscilloscope and tested by nist software.

Journal: Chaos (Woodbury, N.Y.) (2021)
Publication types: Journal Article
Long-term ambient PM2.5exposure associated with cardiovascular risk factors in Chinese less educated population.

Introduction long-term exposure to ambient air pollution is related to major cardiovascular risk factors including diabetes, hypertension, hyperlipidemia and overweight, but with few studies in high-concentration nations like china so far.We aimed to investigate the association between long-term exposure to ambient fine particulate matter (particles with an aerodynamic diameter ≤ 2.5 μm, pm2.5) and major cardiovascular risk factors in china.Methods adult participants with selected biochemical tests were recruited from the chinese physiological constant and health condition (cpchc) survey conducted from 2007 to 2011.Gridded pm2.5data used were derived from satellite-observed data with adjustment of ground-observed data.District-level pm2.5data were generated to estimate the association using multivariate logistic regression model and generalized additive model.Results a total of 19,236 participants from the cpchc survey were included with an average age of 42.8 ± 16.1 years, of which nearly half were male (47.0%).The annual average pm2.5exposure before the cpchc survey was 33.4 (14.8-53.4) μg/m3, ranging from 8.0 μg/m3(xiwuqi) to 94.7 μg/m3(chengdu).Elevated pm2.5was associated with increased prevalence of hypertension (odds ratio (or) =1.022, 95% confidence interval (95%ci): 1.001, 1.043) and decreased prevalence of overweight (or = 0.926, 95%ci: 0.910, 0.942).Education significantly interacted with pm2.5in association with all the interesting risk factors.Each 10 μg/m3increment of pm2.5was associated with increased prevalence of diabetes (or = 1.118, 95%ci: 1.037, 1.206), hypertension (or = 1.101, 95%ci: 1.056, 1.147), overweight (or = 1.071, 95%ci: 1.030, 1.114) in participants with poor education, but not in well-educated population.Pm2.5exposure was negatively associated with hyperlipidemia in all participants (or = 0.939, 95%ci: 0.921, 0.957).The results were robust in all the sensitivity analyses.Conclusion association between long-term pm2.5exposure and cardiovascular risk factors might be modified by education.Pm2.5was associated with a higher prevalence of diabetes, hypertension, and overweight in a less-educated population with time-expose dependency.Long-term exposure to pm2.5might be associated with a lower prevalence of hyperlipidemia.

Journal: BMC public health (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A Systematic Review and Meta-Analysis of Combination Behavioral Interventions Co-Targeting Psychosocial Syndemics and HIV-Related Health Behaviors for Sexual Minority Men.

In the u.s., sexual minority men (smm) are disproportionately affected by hiv.Interventions are needed to increase hiv prevention and treatment behaviors, especially among syndemically exposed smm.In recent years, researchers have created and tested combination behavioral interventions co-targeting syndemics and hiv-related health behaviors.We evaluated that literature via systematic review and meta-analysis, identifying 44 trials targeting mental health symptoms, alcohol use, and drug use, as well as sexual risk behavior, antiretroviral adherence, and healthcare engagement.For the randomized controlled trials, we computed between-group, pre-post effect sizes and tested them via random-effects models.Results supported the efficacy of combined interventions with significant, small, positive effects for improving mental health and reducing substance use (d= .20, cis: 0.12, .29), and reducing sexual risk behavior and improving antiretroviral adherence (d= .16, cis: .03, .30).Stratification analyses indicate that longer (9+ sessions) and individual (vs.Group) interventions resulted in stronger effects on syndemic but not health behavior outcomes.Intervention developers should attend to intervention intensity and format.More evidence is needed about the importance of additional factors, such as novel intervention targets and cultural tailoring, as well as broadening the focus to multi-level interventions to address both interpersonal and structural mechanisms of change.

Journal: Journal of sex research (2020)
Publication types: Journal Article;Meta-Analysis;Systematic Review
Development of Machine Learning Algorithms for Prediction of 30-Day Mortality After Surgery for Spinal Metastasis.

Preoperative prognostication of short-term postoperative mortality in patients with spinal metastatic disease can improve shared decision making around end-of-life care.Objective to (1) develop machine learning algorithms for prediction of short-term mortality and (2) deploy these models in an open access web application.Methods the american college of surgeons, national surgical quality improvement program was used to identify patients that underwent operative intervention for metastatic disease.Four machine learning algorithms were developed, and the algorithm with the best performance across discrimination, calibration, and overall performance was integrated into an open access web application.Results the 30-d mortality for the 1790 patients undergoing surgery for spinal metastatic disease was 8.49%.Preoperative factors used for prognostication were albumin, functional status, white blood cell count, hematocrit, alkaline phosphatase, spinal location (cervical, thoracic, lumbosacral), and severity of comorbid systemic disease (american society of anesthesiologist class).In this population, machine learning algorithms developed to predict 30-d mortality performed well on discrimination (c-statistic), calibration (assessed by calibration slope and intercept), brier score, and decision analysis.An open access web application was developed for the best performing model and this web application can be found here: conclusion machine learning algorithms are promising for prediction of postoperative outcomes in spinal oncology and these algorithms can be integrated into clinically useful decision tools.As the volume of data in oncology continues to grow, creation of learning systems and deployment of these systems as accessible tools may significantly enhance prognostication and management.

Journal: Neurosurgery (2019)
Publication types: Journal Article
Individual and family characteristics associated with health indicators at entry into multidisciplinary pediatric weight management: findings from the CANadian Pediatric Weight management Registry (CANPWR).

S (1) to explore individual and family characteristics related to anthropometric and cardiometabolic health indicators and (2) examine whether characteristics that correlate with cardiometabolic health indicators differ across severity of obesity at time of entry to canadian pediatric weight management clinics.Methods we conducted a cross-sectional analysis of 2-17 year olds with overweight or obesity who registered in the canadian pediatric weight management registry (canpwr) between may 2013 and october 2017 prior to their first clinic visit.Individual modifiable health behaviors included dietary intake, physical activity, screen time, and sleep.Family characteristics included parental bmi, family medical history, socioeconomic status and family structure.Linear mixed effects stepwise regression analysis was performed to determine which characteristics were related to each health indicator: bmi z-score; waist circumference; waist to height ratio; blood pressure; glycemia; hdl cholesterol; non-hdl cholesterol; triglycerides.Results this study included 1296 children (mean age ± standard deviation: 12.1 ± 3.5 years; bmi z-score: 3.55 ± 1.29; 95.3% with obesity).Hours spent sleeping (estimated β = -0.10; 95% ci [-0.15, -0.05], p = 0.0001), hours per week of organized physical activity (estimated β = -0.32; 95% ci [-0.53, -0.11], p = 0.0026), daily sugared drink intake (estimated β = 0.06; 95% ci [0.01, 0.10], p = 0.0136) and maternal bmi (estimated β = 0.03; 95% ci [0.02, 0.04], p < 0.0001) were associated with bmi z-score (adj.R2= 0.2084), independent of other individual and family characteristics.Physical activity, total sugared drink intake and sleep duration were associated with glycemia and non-hdl cholesterol, independent of child bmi z-score.However, irrespective of obesity severity, little of the variance (0.86-11.1%) in cardiometabolic health indicators was explained by individual modifiable health behaviors.Conclusions physical activity, total sugared drink intake and hours spent sleeping were related to anthropometric and some cardiometabolic health indicators in children entering pediatric weight management programs.This highlights the importance of these modifiable health behaviors on multiple health indicators in children with obesity.

Journal: International journal of obesity (2005) (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A parent-led intervention to promote recovery following pediatric injury: study protocol for a randomized controlled trial.

Injury is one of the most prevalent potentially emotionally traumatic events that children experience and can lead to persistent impaired physical and emotional health.There is a need for interventions that promote full physical and emotional recovery and that can be easily accessed by all injured children.Based on research evidence regarding post-injury recovery, we created the cellie coping kit for children with injury intervention to target key mechanisms of action and refined the intervention based on feedback from children, families, and experts in the field.The cellie coping kit intervention is parent-guided and includes a toy (for engagement), coping cards for children, and a book for parents with evidence-based strategies to promote injury recovery.This pilot research trial aims to provide an initial evaluation of the impact of the cellie coping kit for children with injury on proximal targets (coping, appraisals) and later child health outcomes (physical recovery, emotional health, health-related quality of life).Method / design eighty children (aged 8-12 years) and their parents will complete a baseline assessment (t1) and then will be randomly assigned to an immediate intervention group or waitlist group.The cellie coping kit for injury intervention will be introduced to the immediate intervention group after the t1 assessment and to the waitlist group following the t3 assessment.Follow-up assessments of physical and emotional health will be completed at 6 weeks (t2), 12 weeks (t3), and 18 weeks (t4).Discussion this will be one of the first randomized controlled trials to examine an intervention tool intended to promote full recovery after pediatric injury and be primarily implemented by children and parents.Results will provide data on the feasibility of the implementation of the cellie coping intervention for injury as well as estimations of efficacy.Potential strengths and limitations of this design are discussed.Trial registration clinicaltrials.gov, nct03153696 .Registered on 15 may 2017.

Journal: Trials (2019)
Publication types: Clinical Trial Protocol;Journal Article
Vagal Nerve Palsy After Transarterial Embolization of Transverse-Sigmoid Dural Arteriovenous Fistula Using Onyx.

We report a case of a 70-year-old man who developed a transverse-sigmoid dural arteriovenous fistula (ts-davf) that was successfully treated by transarterial embolization (tae) with onyx.Case presentation the patient presented with sudden and progressive disturbance of consciousness and left hemiparesis.Magnetic resonance imaging (mri) revealed venous infarction and hemorrhagic changes with brain swelling in the right parietal lobe.Angiography revealed a right ts-davf and multiple occlusions with retrograde leptomeningeal venous drainage into the cortical veins.The ts-davf was graded as borden type iii and cognard type iia+b.Because of its progressive clinical nature and wide distribution of davf in the occluded sinus wall, he underwent emergent tae with liquid embolic materials including n-butyl cyanoacrylate and onyx under informed consent by his family.Complete obliteration of the ts-davf was achieved, leading to a marked amelioration of symptoms, and mri after treatment confirmed a decrease in the brain swelling.However, he suffered transient dysphagia due to right vagal nerve palsy caused by occlusion of vasa nervorum of ascending pharyngeal artery.He returned home 5 months later with a modified rankin scale of 1.Conclusions tae with onyx appears to be effective for aggressive ts-davf with a widely distributed shunt.However, the blood supply to the cranial nerves and potentially dangerous anastomoses between the external-internal carotid artery and vertebral artery should be taken into account to avoid serious complications.

Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (2019)
Publication types: Case Reports;Journal Article
Mechanisms of cetyltrimethyl ammonium chloride-induced toxicity to photosystem II oxygen evolution complex of Chlorella vulgaris F1068.

Microalgae photosynthesis is sensitive to coexisted contaminates in aquatic environment, thereby causes adverse effect on algal growth and nutrients uptake.Here, we investigated the photosynthetic toxicity mechanism of cetyltrimethyl ammonium chloride (ctac)-induced on a green microalga chlorella vulgaris f1068 (c.Vulgaris f1068).Results showed that ctac reduced the algal growth rate, nutrients removal efficiency and weakened the photosynthetic performance.Meanwhile, the efficiency of oxygen evolution complex (oec) and oxygen evolvement rates stressed by ctac were significantly declined to 90.48% and 58.48% of the control (without ctac), respectively.In addition, atomic force microscopy (afm) detected the damage of psii-oec morphology and structure by ctac.Furthermore, proteomic analysis showed that 41% of proteins were in the chloroplast thylakoid membranes which function in photosynthesis.The activity of oxygen-evolving enhancer protein 2 (oee2 or psb p) involved in electron transfer was significantly inhibited by ctac, which down-regulated 15.14-fold in the presence of 0.6 mg/l ctac.These results indicated that photosynthetic inhibition of ctac mainly occurred in the psii-oec.This study provided a new perspective of the photosynthetic response in evaluation of environmental bioimpacts of surfactants on microalgae.

Journal: Journal of hazardous materials (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Social distancing as risk reduction strategy during COVID-19 pandemic: A study of Delhi-NCT, India.

Covid-19 pandemic impacted countries all over the world calling as urgent need to enhance the capacity of individuals and communities to respond in such disease outbreaks.Public health interventions, such as social distancing could help to protect many vulnerable people and reduce secondary transmissions within the community.This research was undertaken as a longitudinal study to identify and comprehend the preferences given to different preventive measures adopted by individuals to ensure protection against the spread of coronavirus.An online survey was conducted with a representative sample of 176 stakeholders to identify practices and behaviour adopted by the key stakeholders working in the domains of water, health and disaster risk reduction to curb the spread of covid-19 in delhi-national capital territory of india (delhi-nct).Findings of this study shown preferred willingness to adopt sanitisation measures, often by cleaning their hands with soap and water, and restricting any movement inside and outside of the house.Three-fourth of the respondents considered washing their hands after returning from outside an important measure to limit the spread of the disease.Moreover, two-third of the people stopped ordering food from outside as a prevention strategy.Furthermore, only about 36% of the respondents showed interest in stocking up on grocery items as their most preferred choice, reflecting that this was considered to be the least important of all choices.Research outcomes of this study will help policymakers to better understand mitigation options that are used in the early and later stages of the lockdown to improve resilience from such viruses.Further, it will assist decision-makers to understand the range of individual-level practices adopted by stakeholders to mitigate disease transmission at the community level and inform the government's planning efforts in the future.

Journal: International journal of disaster risk reduction : IJDRR (2021)
Publication types: Journal Article
Outcomes of open reduction and internal fixation of proximal humerus fracture dislocations.

Introduction proximal humeral fracture with associated glenohumeral dislocation (phfd) is a challenging clinical problem.Outcomes of open reduction and internal fixation (orif) of these injuries have not been widely reported.The purpose of this analysis is to report our experience with orif of phfd.Methods a retrospective review of our 2 institutions' shoulder surgery databases was conducted to identify all phfds that were treated with orif from 2008 through 2017.Radiographs were reviewed for fracture healing by 12 weeks postoperatively.All reoperations were recorded.Patient-reported outcomes using simple shoulder test (sst) and american shoulder and elbow surgeons standardized shoulder assessment form (ases) scores at a minimum 2-year follow-up were recorded.Results there were 20 phfds identified: they were 50% male, 55.8 ± 10.3 years old (range 31.3-66.3), and had a body mass index of 29.3 ± 8.2 (15.2-47.8).Seven (35%) patients experienced varus collapse, nonunion, or avascular necrosis and 6 (30%) patients underwent reoperation.Of the 17 patients who did not go on to revision or arthroplasty, 14 (82.3%) had patient-reported outcomes at a mean follow-up of 4.9 ± 2.2 years (2.3-8.8).These patients had an average sst 8.0±4.0 yes responses (0-12) and ases scores of 71.6 ± 20.4 (20.2-94.9).Conclusion orif of phfd carries a high rate of reoperation.In patients who achieve healing, functional scores are satisfactory.This information is important for proper patient counseling prior to surgery.

Journal: Journal of shoulder and elbow surgery (2021)
Publication types: Journal Article
Cryo-EM structure of the nucleosome core particle containing Giardia lamblia histones.

Giardia lamblia is a pathogenic unicellular eukaryotic parasite that causes giardiasis.Its genome encodes the canonical histones h2a, h2b, h3, and h4, which share low amino acid sequence identity with their human orthologues.We determined the structure of the g.Lamblia nucleosome core particle (ncp) at 3.6 å resolution by cryo-electron microscopy.G.Lamblia histones form a characteristic ncp, in which the visible 125 base-pair region of the dna is wrapped in a left-handed supercoil.The acidic patch on the g.Lamblia octamer is deeper, due to an insertion extending the h2b α1 helix and l1 loop, and thus cannot bind the lana acidic patch binding peptide.The dna and histone regions near the dna entry-exit sites could not be assigned, suggesting that these regions are asymmetrically flexible in the g.Lamblia ncp.Characterization by thermal unfolding in solution revealed that both the h2a-h2b and dna association with the g.Lamblia h3-h4 were weaker than those for human h3-h4.These results demonstrate the uniformity of the histone octamer as the organizing platform for eukaryotic chromatin, but also illustrate the unrecognized capability for large scale sequence variations that enable the adaptability of histone octamer surfaces and confer internal stability.

Journal: Nucleic acids research (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A dual-omics approach for profiling plant responses to biostimulant applications under controlled and field conditions.

A comprehensive approach using phenomics and global transcriptomics for dissecting plant response to biostimulants is illustrated with tomato (solanum lycopersicumcv.Micro-tom and rio grande) plants cultivated in the laboratory, greenhouse, and open field conditions.Biostimulant treatment based on an ascophyllum nodosumextract (ane) was applied as a foliar spray with two doses (1 or 2 l ha-1) at three different phenological stages (bbch51, bbch61, and bbch65) during the flowering phase.Both ane doses resulted in greater net photosynthesis rate, stomatal conductance, and fruit yield across all culture conditions.A global transcriptomic analysis of leaves from plants grown in the climate chamber, revealed a greater number of differentially expressed genes (degs) with the low ane dose compared to the greater one.The second and third applications induced broader transcriptome changes compared to the first one, indicating a cumulative treatment effect.The functional enrichment analysis of degs highlighted pathways related to stimulus-response and photosynthesis, consistent with the morpho-physiological observations.This study is the first comprehensive dual-omics approach for profiling plant responses to biostimulants across three different culture conditions.

Journal: Frontiers in plant science (2022)
Publication types: Journal Article