syedzayyan/paper_mill_benchmark huggingface dataset:
The Effect and Mechanism of Burnet Gels on Steroid-Dependent Dermatitis in Guinea Pig Model

This study was designed to establish quality standards of burnet gels and investigate the effects and mechanism of burnet gels on steroid‐dependent dermatitis (hdd) in guinea pigs.Methods .Hplc was used to determine the content of gallic acid, gentiopicrin, and paeonol.A total of 48 male guinea pigs were recruited and randomly divided into control group, model group, tacrolimus ointment group, and burnet gel group (low, medium, and high concentration).The hdd guinea pig model was established by the 0.5% clobetasol propionate tincture.After hdd model establishment, control group and model group smeared normal saline and the rest of the group with corresponding drugs for three weeks.The contents of ifn‐ γ , il‐4, and ig e in the guinea pig serum were detected by the elisa; the protein expression levels of flg, lor, and caspase‐14 in the epidermis of guinea pigs were detected by the immunohistochemical and western blotting method.Results .The content of gallic acid, gentiopicrin, and paeonol was 0.30 mg/g, 1.06 mg/g, and 0.56 mg/g.Compared with the normal group, the ifn‐ γ , il‐4, and ig e of guinea pig serum in the model group were significantly increased; the flg, lor, and caspase‐14 of guinea pig epidermis in the model group were significantly decreased; compared with the model group, the ifn‐ γ , il‐4, and ig e of guinea pig serum in the tacrolimus ointment group and burnet gel group were significantly decreased; the flg, lor, and caspase‐14 of guinea pig epidermis in the tacrolimus ointment group and burnet gel group were significantly increased.Conclusion .Burnet gels can improve guinea pig hdd model, and the mechanism may be related to inhibiting skin inflammation and promoting the formation of epidermal skin barrier.

Journal: BioMed Research International (2022)
Publication types: Research Article;
The Application of Modern Computer-Aided Technology in Fine Art Education

With the popularization of modern computer technology, human society has stepped into the information age.Modern computer technology will have an all-round and deep impact on fine art education in china.In fine art education, various information devices play an important role in broadening the resources of fine art education and effectively improving the quality of fine art education.This study analyzes fine art education in the digital era and studies how the quality of fine art education can be improved through computer-aided technology.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
The Application and Teaching of Digital Technology in Printmaking

Along with the popularization of digital technology, artists began to use digital technology as a technological means to make more attempts in the creation of print art, thereby breaking through the formal constraints.The diversity of information technology inspires artists’ creative inspiration and makes the development of art move in a more varied and diversified direction.The new vision brought by digital technology, digital printmaking, comprehensive printmaking, and digital technology in the creation of comprehensive printmaking and its positive influence on the future development of printmaking provide favorable conditions for the development of diversified art.This paper takes the application of digital technology in the creation of comprehensive prints as a research point and separately expounds the development and application background of digital computer technology and the development history of traditional prints, thereby extending to the modern combination of these two techniques and then transitioning to today’s synthesis print.Based on the background of modernity and history, this article analyzes the classical language forms and characteristics of traditional printmaking to comprehensive printmaking from the theory and practice.And based on the techniques of software plate-making technology, it has been expanded to a series of specific measures such as materials and mechanisms.The research in this paper shows that artists can use digital prints to create high-impact works of art with higher quality and more artistic content.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Targeted Diagnosis, Therapeutic Monitoring, and Assessment of Atherosclerosis Based on Mesoporous Silica Nanoparticles Coated with cRGD-Platelets

The off-target effects and severe side effects of pparα and lxrα agonists greatly limit their application in atherosclerosis (as).Therefore, this study intended to use mesoporous silica nanoparticles as carriers to generate mn o nanoparticles in situ with t1wi-mri in mesoporous pores and simultaneously load pparα and lxrα agonists.Afterward, c rgd-chelated platelet membranes can be used for coating to construct a new nanotheranostic agent.Methods.C rgd-platelet@mn o/msn@pparα/lxrα nanoparticles were synthesized by a chemical method.Dynamic light scattering (dls) was utilized to detect the size distribution and polydispersity index (pdi) of the nanoparticles.The safety of the nanoparticles was detected by cck8 in vitro and he staining and kidney function in vivo.Cell apoptosis was detected by flow cytometry detection and tunel staining.Oxidative stress responses (ros, sod, mda, and nox levels) were tested via a dcfh-da assay and commercial kits.Immunofluorescence and phagocytosis experiments were used to detect the targeting of nanoparticles.Magnetic resonance imaging (mri) was used to detect the imaging performance of c rgd-platelet@mn o/msn@pparα/lxrα nanoparticles.Using western blotting, the expression changes in lxrα and abca1 were identified.Results.C rgd-platelet@mn o/msn@pparα/lxrα nanoparticles were successfully established, with a particle size of approximately 150 nm and pdi less than 0.3, and showed high safety both in vitro and in vivo.C rgd-platelet@mn o/msn@pparα/lxrα nanoparticles showed good targeting properties and better mri imaging performance in as.C rgd-platelet@mn o/msn@pparα/lxrα nanoparticles showed better antioxidative capacities, mri imaging performance, and diagnostic and therapeutic effects on as by regulating the expression of lxrα and abca1.Conclusion.In the present study, c rgd-platelet@mn o/msn@pparα/lxrα nanoparticles with high safety and the capacity to target vulnerable plaques of as were successfully established.They showed better performance on mri images and treatment effects on as by promoting cholesterol efflux through the regulation of abca1.These findings might address the problems of off-target effects and side effects of nanoparticle-mediated drug delivery, which will enhance the efficiency of as treatment and provide new ideas for the clinical treatment of as.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Synthesis and Properties of Supramolecular Crops Based on PNZST Antiferroelectric Film

With the rapid development of ecological agriculture and the continuous changes of the ecological environment, crops are facing tremendous challenges.At the same time, people’s demand for the number and variety of crops is gradually increasing, so the synthesis and performance improvement of crops is imminent.The emergence of supramolecular crops has brought about huge changes in the yield of crops.In this paper, for the purpose of reducing the cost of crops and enhancing the ability of crops to adapt to the environment, pnzst antiferroelectric film materials are used to study the synthesis of supramolecular crops.Among them, rice, corn, and soybeans are used as reference objects for synthetic crops.Experiments were carried out in four aspects: growth rate, growth cycle, and yield.The growth status of the three crops in the past four years was monitored and recorded and analyzed.The survival rate of traditional rice was 86.3%–89.5%, the growth cycle was 86–90 days, and the yield was 69–77 kg/ha; the survival rate of traditional corn was 85.6%–89%, the growth cycle was 105–114 days, and the yield was 38–43 kg/ha; the survival rate of traditional soybean was 85.6%–89%, the growth cycle was 85–90 days, and the output was 14–16 kg/ha.The survival rate of synthetic rice was 95.5%–96.9%, the growth cycle was 63–66 days, and the yield was 83–86 kg/ha; the survival rate of synthetic corn was 97.3%–98.7%, the growth cycle was 85–95 days, and the yield was 53–56 kg/ha; the survival rate of synthetic soybeans was 96.3%–98.3%, the growth cycle was 59–68 days, and the yield was 29–33 kg/ha.

Journal: Advances in Materials Science and Engineering (2022)
Publication types: Research Article;
Susceptibility Loci in SLC15A1, UGT1A3, and CWC27 Genes Associated with Bladder Cancer in the Northeast Chinese Population

Bladder cancer (bca) is an increasingly severe clinical and public health issue.Therefore, we aim to investigate bca susceptibility loci in the chinese population.In this study, 487 bca patients and 563 controls were recruited from the first affiliated hospital of china medical university from july 2015 to september 2020.A total of ten single‐nucleotide polymorphisms (snps) in solute carrier family 15 member 1 (slc15a1), cwc27 spliceosome associated cyclophilin (cwc27), or udp glucuronosyltransferase family 1 member a3 (ugt1a3) genes were genotyped.The associations between the candidate snps and bca were analyzed using genotype and haplotype analysis.The results demonstrated that rs4646227 of slc15a1 has a significant association with bca.The patients with cg (or =2.513, p &lt; 0.05) and gg (or =2.859, p &lt; 0.05) genotypes had an increasing risk of bca compared with the cc genotype.For the cwc27 gene, genotypic frequency analysis revealed that the gt or tt genotype of rs2042329 and the ct or tt genotype of rs1870437 were more frequent in bca patients than those in the control group, indicating that these genotypes were associated with a higher risk of bca (all p &lt; 0.05).Haplotypes of slc15a1 , ugt1a3 , and cwc27 genes found that the c‐c‐c haplotype of slc15a1 was associated with a lower risk of bca while the c‐g‐c haplotype was associated with a higher risk.For the ugt1a3 gene, a moderate protective effect was observed with the most frequent t‐t‐c haplotype, and for the cwc27 gene, most of the haplotypes showed no association with bca, except the g‐g‐c‐t haplotype (order of snps: rs2042329‐rs7735338‐rs1870437‐rs2278351, or =0.81, p =0.038).In sum, this study indicated that rs2042329 and rs1870437 in the cwc27 gene and rs4646227 in the slc15a1 gene are independent indicators for bca risk in chinese people.Further large‐scale studies are required to validate these findings.Also, this study provided the theoretical basis for developing new therapeutic drug targeting of bca.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Study on the Intention of Foreign Trade Driven by Cross-Border E-Commerce Based on Blockchain Technology

Cross-border e-commerce is also facing the problems of cross-border goods selling counterfeit, long delivery time of cross-border logistics, and high cross-border payment fee in the process of development.Blockchain technology, with its characteristics of high trustworthiness, traceability, and information immutability, can be applied to the field of cross-border e-commerce, providing a new direction for cross-border e-commerce to solve these problems.At the present stage, scholars at home and abroad mainly study how blockchain technology is applied in cross-border e-commerce, explore the specific mode of combining blockchain technology with cross-border e-commerce, and lay the theoretical foundation for the application of blockchain technology in cross-border e-commerce, while less research is conducted on the application effect of blockchain technology in cross-border e-commerce.Based on this, this paper researches the influence mechanism of the application of blockchain technology in cross-border e-commerce on consumers’ willingness to purchase, explains the current situation of the application of blockchain technology in various fields of cross-border e-commerce, and on this basis, divides the quality of the blockchain system of cross-border e-commerce into three dimensions of commodity information quality, logistics service quality, and payment security.

Journal: Security and Communication Networks (2021)
Publication types: Research Article;
Study on Key Technologies of Virtual Interactive Surgical Simulation for 3D Reconstruction of Medical Images

Medical computed tomography (ct), nuclear magnetic resonance imaging (mri), and other imaging facility produce a large amount of medical image data which has great diagnosis value.Traditional three‐dimensional reconstruction of medical images has high requirements for graphics acceleration hardware and the processing speed.In this study, vx works embedded real‐time process feature is used for ct or mri dicom data to real restoration and establishment of virtual three‐dimensional model for realizing volume reconstruction, maximum density projection, multiplane reconstruction, dynamic interactive cutting of any surface, dynamic display of three‐dimensional model and two‐dimensional sectional image, surgical path planning and interactive surgical simulation, and determine the best surgical scheme.The practical application shows that the virtual simulation environment supports the seamless transplantation of code, function debugging, and interaction and solves the issue of high requirements for hardware.It can meet the needs of scientific research and teaching for clinicians and medical imaging workers and can be widely used in the training of virtual surgical anatomy for medical students.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Strategies to Improvise Organ Donor Pool: A Study on the Knowledge, Attitudes, and Performance of Higher Secondary School Teachers Towards the Organ Donation

Introduction .This study aimed to assess higher secondary school teachers’ knowledge, attitude, and performance levels towards organ transplantation and donation (otd).Teachers have an essential role in giving knowledge to children and teenagers, and they can influence their views.Organ transplantation offers re‐life to many patients, yet organ shortages are a global issue.Teachers who influence students’ future attitudes regarding organ donation must have a favorable attitude and genuine knowledge.Materials and methods .The research method was descriptive and cross‐sectional.The sample size was 372 school teachers in villupuram district of tamilnadu, india, selected using a convenient sampling method.A survey questionnaire was used to assess the knowledge and attitude about otd, the reason for donating/not donating organs.Multivariate analysis was performed to identify critical variables affecting intent to practice.Results .The teachers’ mean scores with sd on knowledge, attitude, and performance were 7.61 ± 2.74, 8.81 ± 2.08, and 0.38 ± 0.11, respectively.The linear regression analysis showed that the knowledge ( p &lt; 0.001) and attitude ( p &lt; 0.05) of the participants were positively associated with organ donation performance.A significant relationship was also observed between gender ( p &lt; 0.036), age ( p &lt; 0.01), and education status ( p &lt; 0.001) with the performance of the teachers.Lack of family support was the most spelt reason for unwillingness for organ donation.Conclusion .The positive linear correlations underline that having more information may lead to a more optimistic mindset and, as a result, to better practices.Teachers should be provided with overall health teaching campaigns to increase the number of possible organ donors.Teachers serve as role models for students, families, and society by changing their attitudes.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Single-Cell Transcriptomics Analysis of the Pathogenesis of Tendon Injury

Tendon injury repair has been a clinical challenge, and little is known about tendon healing scar generation, repair, and regeneration mechanisms.To explore the cellular composition of tendon tissue and analyze cell populations and signaling pathways associated with tendon repair, in this paper, single-cell sequencing data was used for data mining and seven cell subsets were annotated in the tendon tissue, including fibroblasts, tenocytes, smooth muscle cells, endothelial cells, macrophages, t cells, and plasma cells.According to cell group interaction network analysis, pattern 4 composed of macrophages was an important communication pattern in tendon injury.Furthermore, the heterogeneity of m1 macrophages in tendons, the correlation of kegg enriched pathway with inflammatory response, and the core regulatory role of the transcription factor nfkb and rel were observed; in addition, the heterogeneity of t cell isoforms in tendons was found and indicated that different isotypes of t cells involve in different roles of tendon injury and repair.This study demonstrated the heterogeneity of m1 macrophages and t cells in the tendon tissue, being involved in different physiological processes such as tendon injury and healing, providing new thinking insights and basis for subsequent clinical treatment of tendon injury.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Single-Cell Transcriptional Profiling Reveals Low-Level Tragus Stimulation Improves Sepsis-Induced Myocardial Dysfunction by Promoting M2 Macrophage Polarization

Sepsis can lead to multiple organ damage, of which the heart is one of the most vulnerable organs.Vagal nerve stimulation can reduce myocardial injury in sepsis and improve survival rates.However, the potential impact of low-level tragus stimulation and disparate cell populations on sepsis-induced myocardial dysfunction remains undetermined.Methods.A cardiac single-cell transcriptomic approach was used for characterizing cardiac cell populations that form the heart.Single-cell m rna sequencing data were used for selecting all cardiac macrophages from cd45+ cells.Then, echocardiography, western blot, flow cytometry, immunofluorescence, and immunohistochemistry were performed to verify the single-cell m rna sequencing results.Results.Using single-cell m rna sequencing data, we uncovered the multiple cell populations contributing to myocardial injury in sepsis under low-level tragus stimulation, thereby illustrating a comprehensive map of the cardiac cellular landscape.Pseudotiming analysis in single-cell sequencing showed that low-level vagal nerve stimulation played an anti-inflammatory role by promoting cardiac monocytes into m2 macrophages, which significantly increased α7n ach r expression in heart tissues.Echocardiography assessment indicated that low-level vagal nerve stimulation could also improve cardiac functions in mice with sepsis-induced myocardial dysfunction.In addition, the heart tissues of mice from the sepsis group with low-level tragus stimulation had significantly lower interleukin-1β expression levels than those from the sepsis group.Flow cytometry analysis showed that different acetylcholine concentrations promoted cardiac monocytes into m2 macrophages in in vitro experiments.Conclusion.Low-level tragus stimulation could improve sepsis-induced myocardial dysfunction by promoting cardiac monocytes to m2 macrophages.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Screening of Adverse Prognostic Factors and Construction of Prognostic Index in Previously Untreated Concurrent Follicular Lymphoma and Diffuse Large B-Cell Lymphoma

Concurrent follicular lymphoma (fl) and diffuse large b‐cell lymphoma (dlbcl) (defined as fl/dlbcl) have been considered an important pathological feature in cell lymphoma.However, clinicopathological information and prognostic factors in these cases are scarce.The aim of this study was to construct a prediction index to compare with traditional prognostic models.Methods .Retrospectively enrolled, previously untreated fl/dlbcl ( n = 121) patients, as well as those with pure fl 1–3a ( n = 471), were assessed.De novo dlbcl ( n = 529) were used as controls.Kaplan–meier curves were plotted to compare the outcomes among the three groups.Multivariate analysis identified risk factors associated with overall survival (os) in fl/dlbcl patients.A clinicopathological prognosis index (cppi) was developed to predict os based on the cox proportional hazards model.Results .The outcomes of fl/dlbcl patients were intermediate between pure fl 1–3a and de novo dlbcl patients, with a 5‐year pfs of 70%, 59%, and 48% ( p &lt; 0.05) and 5‐year os of 80%, 70% and 60% ( p &lt; 0.05), respectively.Cox regression analysis showed that the prognostic factors of os for fl/dlbcl patients included fl grade, cell of origin, and ann arbor stage.A nomogram and clinicopathological prognostic index (cppi) were developed to predict the os for fl/dlbcl patients based on these factors.The area under the curve (auc) of the cppi for 3‐ and 5‐year os prediction was 0.782 and 0.860, respectively.This was superior to that of the international prognostic index (ipi), follicular lymphoma international prognostic index (flipi), and flipi2 in the 0.540–0.819 ( p &lt; 0.01) range.Conclusions .A valid os estimation in fl/dlbcl patients, using the recommended cppi, may be useful in routine clinical practice.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Safety and Efficacy of CT-Guided Central Venous Catheter Gastric Insufflation in Percutaneous Gastrostomy

Gastric insufflation for computed tomography (ct)‐guided percutaneous gastrostomy is currently performed via a nasogastric tube or a chiba needle.However, nasogastric tube placement requires patient pharynx and esophagus, and chiba needle use is associated with an increased risk of organ damage and prolonged operation time.Herein, we introduce a new method of gastric insufflation via a central venous catheter and explore its safety and efficacy by retrospective analysis of the clinical data of patients who underwent percutaneous gastrostomy using this method in our hospital from april 2021 to march 2022.The extracted data included the following: success rate, operation time, gastric insufflation time, radiation dose, postoperative pain score, and complications.We also compared the preoperative levels of several nutritional indicators (body mass index, hemoglobin, albumin, creatinine, and blood urea nitrogen) with those obtained 1 month postoperatively.A total of 12 patients underwent percutaneous gastrostomy under ct guidance using central venous catheter gastric insufflation.The surgery and gastric insufflation success rates were 100% both.The average operation time, gastric insufflation time, and effective radiation dose were 24.08 ± 5.25 min, 5.08 ± 2.50 min, and 14.16 ± 3.63 m sv, respectively.Based on the world health organization scale for pain assessment, five patients reported no postoperative pain and seven patients had mild pain.There were no serious complications, such as stoma infection, peritonitis, gastrointestinal perforation and bleeding, or embedding syndrome.All evaluated nutritional indicators showed improvement at 1 month postoperatively, with statistically significant differences compared to the preoperative values ( p &lt; 0.05 for all).In conclusion, ct‐guided percutaneous gastrostomy with central venous catheter gastric insufflation is a safe, effective, and feasible minimally invasive treatment.

Journal: BioMed Research International (2022)
Publication types: Research Article;