syedzayyan/paper_mill_benchmark huggingface dataset:
Incipient empyema as an embolic complication of group A streptococcal septic arthritis in a patient with concomitant influenza B infection.

A 43-year-old healthy male presented with left ankle septic arthritis.Surgical specimens cultured streptococcus pyogenes(group a streptococcus, gas) and iv benzylpenicillin was commenced.In the setting of coryzal symptoms, a chest radiograph and nasopharyngeal swab revealed a left-sided pleural effusion and influenza b infection, respectively.Persisting fevers, rising crp, and increasing breathlessness led to repeat chest radiography showing a rapidly enlarging left-sided effusion.Following intercostal catheter insertion with intrapleural fibrinolytic therapy, 6 l of haemorrhagic fluid was drained leading to defervescence and clinical improvement.At follow-up 4 weeks later, he was asymptomatic with a normal chest radiograph.Similar to previous reported cases of gas empyema, this case was associated with concurrent viral respiratory tract infection, but is unusual as it arose through haematogenous seeding from an extra-thoracic source.This case reminds clinicians to be aware of the strongly pyogenic nature of gas and its significance as a potential cause of pleural infection, especially in patients with concomitant viral respiratory infections.

Journal: Respirology case reports (2022)
Publication types: Case Reports;Journal Article
The genome sequence of a carabid beetle,Nebria salina(Fairmaire & Laboulbène, 1854).

We present a genome assembly from an individual female nebria salina(a carabid beetle; arthropoda; insecta; coleoptera; carabidae).The genome sequence is 256.7 megabases in span.Most of the assembly is scaffolded into 21 chromosomal pseudomolecules, including the assembled x sex chromosome.The mitochondrial genome has also been assembled and is 24.7 kilobases in length.Gene annotation of this assembly on ensembl identified 10,671 protein coding genes.

Journal: Wellcome open research (2023)
Publication types: Journal Article
Can drawing instruction help students with low visuospatial ability in learning anatomy?

Visuospatial skills are considered important attributes when learning anatomy and there is evidence suggesting that this ability can be improved with training techniques including drawing.The mental rotations test (mrt) has been routinely used to assess visuospatial ability.This study aimed to introduce students to drawing as a learning strategy for anatomy.Undergraduate speech science anatomy students took part in a drawing tutorial (n = 92), completed an mrt test, pre- and post-tutorial tests, and surveys regarding their use and attitudes toward drawing as a study tool.The impact on their examination performance was then assessed.Regardless of mrt score or attitude to drawing, students who participated in the drawing tutorial demonstrated immediate improvement in post-tutorial test scores.Students in the drawing group performed better in most anatomy components of the examination, but the result did not reach statistical significance.There was only a positive correlation between mrt score and one type of anatomy question (non-image-based) and speech physics questions (r = 0.315, p = 0.002).The unexpected finding may relate to the mrt which assesses spatial rather than object visualization skills.Students who liked drawing also performed significantly better in word-based and speech physics questions.It is likely that the style of identification question did not require the mental manipulation ability assessed in the mrt.This study demonstrated that students with lower mrt scores are not outperformed in all aspects of anatomy assessment.The study highlights the importance of a more nuanced understanding of visuospatial skills required in anatomy.

Journal: Anatomical sciences education (2023)
Publication types: Journal Article
IFNα Potentiates Immune-Checkpoint Blockade by Rewiring Metabolic Cross-talk.

In this issue, hu and colleagues unveil that ifnα administration combined with anti-pd-1 therapy can potentiate murine and human cd8+ t-cell antitumor response in hepatocellular carcinoma, highlighting a novel therapeutic strategy for hepatocellular carcinoma.See related article by hu et al., p.1718 (6) .

Journal: Cancer discovery (2022)
Publication types: Editorial;Comment
The Effects of Pepper (Zanthoxylum bungeanum) from Different Production Areas on the Volatile Flavor Compounds of Fried Pepper Oils Based on HS-SPME-GC-MS and Multivariate Statistical Method.

Fried pepper oil retains the overall flavor outline of pepper, and its unique rich and spicy flavor is deeply loved by consumers.In order to study the effect of different production areas of pepper on the flavor compounds of fried pepper oil, taking dried pepper from seven different production areas as raw materials, and taking rapeseed oil as a carrier oil as well as a constant frying temperature to prepare pepper oil, the present study analyzed the volatile flavor components of pepper oil qualitatively and quantitatively by employing headspace solid phase microextraction (hs-spme) and gas chromatography-mass spectrometry (gc-ms).The principal component analysis (pca) method was used to construct the correlation analysis model of volatile flavor substances among different samples of pepper oil.Applying the hierarchical cluster analysis (hca), the main volatile substances causing the flavor differences of pepper oil from different production areas were identified.The results showed that a total of 81 chemical components were identified, including 15 alcohols, 10 aldehydes, 5 ketones, 34 hydrocarbons, 11 esters, 6 acids, and others.Terpinen-4-ol, linalool, 2,4-decadienal, trans-2-heptenal, sabinene, linalyl acetate, bornyl acetate, myrcene, 1-caryophyllene, trans-α-ocimene, and limonene were selected as the main substances leading to the flavor differences among the pepper oil samples.These 11 chemical components played a decisive role in the construction of the overall aroma of the pepper oil.Using a descriptive sensory analysis, it was concluded that pepper oil from different production areas holds different aroma intensities.Compared with the other six samples, s4 hanyuan pepper oil (hypo) shows a relatively strong trend toward a spicy fragrance, fresh grassy fragrance, floral and fruity fragrance, fresh sweet fragrance, and fatty aroma.

Journal: Molecules (Basel, Switzerland) (2022)
Publication types: Journal Article
The psychological mechanism of construction workers' safety participation: The social identity theory perspective.

Introduction safety participation has gained increasing attention as an important dimension of workers' safety behaviors.Although previous studies attempted to identify factors affecting workers' safety participation, only a few studies paid attention to the psychological mechanisms behind it.Therefore, this study aimed to develop and test a research model that explains how management factors are implicated in workers' safety participation.Specifically, this study focused on project-based organizations (e.g., construction projects) because employee psychological mechanisms may have a unique nature in such transient employment.Method the hypotheses in the research model of the psychological mechanism of construction workers' safety participation are tested using survey data from 261 construction workers.Results the results indicated that construction workers' safety participation is influenced by project identification after controlling the shared variance of safety compliance.Project identification also mediates the effects of transformational leadership and communication climate on safety participation.Practical applications this study offers researchers and practitioners an explanation of how management factors influence construction workers' safety behaviors and clarifies the role of project identification play in explaining the effects of management factors on safety compliance and safety participation.

Journal: Journal of safety research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A novel data-driven methodology for influenza outbreak detection and prediction.

Influenza is an infectious disease that leads to an estimated 5 million cases of severe illness and 650,000 respiratory deaths worldwide each year.The early detection and prediction of influenza outbreaks are crucial for efficient resource planning to save patient's lives and healthcare costs.We propose a new data-driven methodology for influenza outbreak detection and prediction at very local levels.A doctor's diagnostic dataset of influenza-like illness from more than 3000 clinics in malaysia is used in this study because these diagnostic data are reliable and can be captured promptly.A new region index (ri) of the influenza outbreak is proposed based on the diagnostic dataset.By analysing the anomalies in the weekly ri value, potential outbreaks are identified using statistical methods.An ensemble learning method is developed to predict potential influenza outbreaks.Cross-validation is conducted to optimize the hyperparameters of the ensemble model.A testing data set is used to provide an unbiased evaluation of the model.The proposed methodology is shown to be sensitive and accurate at influenza outbreak prediction, with average of 75% recall, 74% precision, and 83% accuracy scores across five regions in malaysia.The results are also validated by google flu trends data, news reports, and surveillance data released by world health organization.

Journal: Scientific reports (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Relevance of hMLH1 -93G>A, 655A>G and 1151T>A polymorphisms with colorectal cancer susceptibility: a meta-analysis based on 38 case-control studies.

There has been increasing interest in the study of the association between human mut l homolog 1 (h mlh1) gene polymorphisms and risk of colorectal cancer (crc).However, results from previous studies are inconclusive.Thus, a meta-analysis was conducted to derive a more precise estimation of the effects of this gene.Methods a comprehensive search was conducted in the pub med, embase, chinese biomedical literature databases until january 1, 2018.Odds ratio (or) with 95% confidence interval (ci) was used to assess the strength of the association.Results finally, 38 case-control studies in 32 publications were identified met our inclusion criteria.There were 14 studies with 20668 cases and 19533 controls on h mlh1 -93g>a, 11 studies with 5,786 cases and 8,867 controls on 655a>g and 5 studies with 1409 cases and 1637 controls on 1151t>a polymorphism.The combined results showed that 655a>g and 1151t>a polymorphisms were significantly associated with crc risk, whereas -93g>a polymorphism was not significantly associated with crc risk.As for ethnicity, -93g>a and 655a>g polymorphisms were associated with increased risk of crc among asians, but not among caucasians.More interestingly, subgroup analysis indicated that 655a>g might raise crc risk in pcr-rflp and hb subgroups.Conclusion inconsistent with previous meta-analyses, this meta-analysis shows that the h mlh1 655a>g and 1151t>a polymorphisms might be risk factors for crc.Moreover, the -93g>a polymorphism is associated with the susceptibility of crc in asian population.

Journal: Revista da Associacao Medica Brasileira (1992) (2018)
Publication types: Journal Article;Meta-Analysis
Cotton straw biochar and Bacillus compound biofertilizer decreased Cd migration in alkaline soil: Insights from relationship between soil key metabolites and key bacteria.

Cadmium (cd) contamination greatly impacts soil health and ecological environment.In recent years, cotton straw biochar and bacillus compound biofertilizer have been paid much attention in the remediation of cd-contaminated soils.In this study, the effects of cotton straw biochar (3%, w/w) and bacillus compound biofertilizer (1.5%, w/w) on the cd fractions, cd migration, bacterial community succession, and metabolites in the soils with different concentrations of cd (1, 2, and 4 mg kg-1) were explored.The results showed that the relative abundance of actinobacteriota, acidobacteriota, firmicutes, and cyanobacteric and soil enzyme activities in cd-contaminated soils decreased, and the soil metabolic pathways also changed compared with those in the control.After the application of cotton straw biochar and bacillus compound biofertilizer, the soil available cd concentration in cd-contaminated soils decreased, and many exchangeable and carbonate-bound cd were transformed into residual cd, which decreased the bioavailability of cd in the soil and the accumulation of cd in cotton organs.In addition, the application of cotton straw biochar and bacillus compound biofertilizer improved the activity of soil enzymes and the abundance of dominant bacteria and stimulated verrucomicrobiota, methylomirabilota, and cyanobacteria to secrete organic acids and amino acid compounds, which decreased the toxicity of cd.Besides, compared with cotton straw biochar, bacillus compound biofertilizer was more effective in immobilizing cd and improving soil environment.This study provides guidance for the remediation of cd-contaminated alkaline soil, and makes contributions to the soil health and sustainable development.

Journal: Ecotoxicology and environmental safety (2022)
Publication types: Journal Article
Hopeless tooth and less posterior occlusion is related to a greater risk of low handgrip strength: A population-based cross-sectional study.

The effect of severely compromised teeth on masticatory function has not been properly evaluated in previous studies, as they were often considered equivalent to the healthy tooth or excluded as if absent in the dentition.Hopeless teeth, which refer to non-salvageable teeth that require extraction, can interfere with masticatory function.As posterior occlusion is directly related to the masticatory function, we evaluated pairs opposing posterior teeth (pops) that reflect the arrangement as well as the number of remaining posterior teeth.This study investigated the relationship of a hopeless tooth to handgrip strength according to pops in the elderly.This cross-sectional study used data from the korea national health and nutrition examination survey (knhanes).Among the data of 23,466 participants from 2015 to 2018, participants aged 60 years or older (n = 4,729) were included.In males with pops scores of 0-7, considered poor posterior occlusion, the association with low handgrip strength persisted in the multivariate logistic regression model adjusted for all confounding variables.The odds ratio (or) in the absence of hopeless teeth (or = 1.91, 95% ci: 1.02-3.59) increased in the presence of a hopeless tooth (or = 2.78, 95% ci: 1.42-5.47).Even with pops scores of 8-11, considered good posterior occlusion, the association was significantly high in the presence of a hopeless tooth (or = 2.82, 95% ci: 1.06-7.52).In females, the association disappeared in adjusted models.The fewer pairs of natural posterior teeth with occlusion, the greater the risk of low handgrip strength.Dentition containing hopeless teeth increases the risk of low handgrip strength, even in dentition with sufficient posterior occlusion.Preserving the posterior teeth in a healthy condition through personal oral hygiene and regular dental management is essential for maintaining components of physical function such as handgrip strength.

Journal: PloS one (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Therapeutic effect of statins on airway remodeling during asthma.

Introduction asthma is a chronic inflammatory disease of the airways, which is usually characterized by remodeling, hyperresponsiveness and episodic obstruction of the airways.The underlying chronic airway inflammation leads to pathological restructuring of both the large and small airways.Since the effects of current asthma medications on airway remodeling have been met with contradictions, many therapeutic agents have been redirected from their primary use for the treatment of asthma.Such treatments, which could target several signaling molecules implicated in the inflammatory and airway remodeling processes of asthma, would be an ideal choice.Areas covered statins are effective serum cholesterol-lowering agents that were found to have potential anti-inflammatory and anti-remodeling properties.Literature search was done for the past 10 years to include research and review articles in the field of statins and asthma complications.In this review, we discuss the role of statins in airway tissue remodeling and their potential therapeutic modalities in asthma.Expert opinion with improved understanding of the role of statins in airway remodeling and inflammation, statins represent a potential therapeutic option for various asthma phenotypes.Further research is warranted to optimize statins for asthma therapy through inhalation as a possible route of administration.

Journal: Expert review of respiratory medicine (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Impact of MRI timing on tumor volume and anatomic displacement for brain metastases undergoing stereotactic radiosurgery.

The objective of this study was to evaluate the impact of the time interval between planning imaging and stereotactic radiosurgery (srs) delivery on tumor volumes and spatial anatomic displacements of brain metastases (bm).Methods consecutive patients diagnosed with bm treated with srs over a 3-year period were evaluated.Only patients who underwent an institutionally standardized diagnostic mri (mri-1) and a treatment planning mri (mri-2) were included.The impact of histology, inter-scan time interval, lesion location, tumor volume, and diameter were evaluated on final lesion diameter, volume, anatomic displacement, and ultimate need for change in management (ie, expanding margins, rescanning).Results 101 patients (531 lesions) with a median inter-scan time interval of 8 days (range: 1-42 days) met the inclusion criteria.The median percentage increase in bm diameter and volume were 9.5% (iqr: 2.25%-24.0%) and 20% (iqr: 0.7%-66.7%).Overall, 147 lesions (27.7%) in 57 patients (56.4%) required a change in management.There was a statistically significant relationship between initial tumor diameter (cm) and change in management (or: 2.69, 95% ci: 1.93-3.75;p< .001).Each day between mri-1 and mri-2 was associated with a change in management with an or of 1.05 (95% ci: 1.03-1.07;p< .001).Conclusions changes in tumor diameter, volume, and spatial position occur as a function of time.Planning imaging for srs is recommended to occur in close temporal proximity to treatment; for those with delays, a larger setup margin may need to be used to ensure tumor coverage and account for positional changes.

Journal: Neuro-oncology practice (2021)
Publication types: Journal Article
Vitamin C enhances NF-κB-driven epigenomic reprogramming and boosts the immunogenic properties of dendritic cells.

Dendritic cells (dcs), the most potent antigen-presenting cells, are necessary for effective activation of naïve t cells.Dcs' immunological properties are modulated in response to various stimuli.Active dna demethylation is crucial for dc differentiation and function.Vitamin c, a known cofactor of ten-eleven translocation (tet) enzymes, drives active demethylation.Vitamin c has recently emerged as a promising adjuvant for several types of cancer; however, its effects on human immune cells are poorly understood.In this study, we investigate the epigenomic and transcriptomic reprogramming orchestrated by vitamin c in monocyte-derived dc differentiation and maturation.Vitamin c triggers extensive demethylation at nf-κb/p65 binding sites, together with concordant upregulation of antigen-presentation and immune response-related genes during dc maturation.P65 interacts with tet2 and mediates the aforementioned vitamin c-mediated changes, as demonstrated by pharmacological inhibition.Moreover, vitamin c increases tnfβ production in dcs through nf-κb, in concordance with the upregulation of its coding gene and the demethylation of adjacent cp gs.Finally, vitamin c enhances dc's ability to stimulate the proliferation of autologous antigen-specific t cells.We propose that vitamin c could potentially improve monocyte-derived dc-based cell therapies.

Journal: Nucleic acids research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Hand Temperature Is Not Consistent With Illusory Strength During the Rubber Hand Illusion.

The rubber hand illusion is known to invoke a sense of ownership of a rubber hand when a person watches the stroking of the rubber hand in synchrony with their own hidden hand.Quantification of the sense of ownership is traditionally performed with the rubber hand illusion questionnaire, but the search for reliable physiological measurements persists.Skin temperature has been previously suggested and debated as a biomarker for ownership.We investigated hand temperature as a measure of rubber hand illusory strength via thermal imaging of the hand during the rubber hand experiment.No relationship was found between reported illusory strength and skin temperature.clinical relevance- our results indicate that skin temperature is not a suitable biomarker for rubber hand illusory strength.

Journal: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Socioeconomic status at diagnosis influences the incremental direct medical costs of systemic lupus erythematosus: A longitudinal population-based study.

S to assess the incremental direct medical costs of a population-based cohort of incident systemic lupus erythematosus (sle) for the first five years after diagnosis, and impact of socioeconomic status (ses) on such incremental costs.Methods from the administrative health databases in british columbia, canada, we identified all adults with newly-diagnosed sle from 1996 to 2010 and obtained a sample from the general non-sle population matched on sex, age, and calendar-year.We captured costs for outpatient encounters, hospitalisations, and dispensed medications.Using two-part generalised linear models, we estimated per-person-year incremental costs of sle (difference in costs between sle and non-sle, controlling for covariates) during the first five years after diagnosis, and assessed differences in incremental costs across ses groups.Results we included 4679 newly-diagnosed sle (86% identified from hospitalisations or rheumatologists) and 23,219 non-sle individuals.Per-person direct costs for sle in the first year after diagnosis averaged $13,038 (2013 canadian), with 61% from hospitalisations, 23% from outpatient encounters, and 16% from medications; costs for non-sle averaged $2,431.Following adjustment, incremental costs of sle during the first five years after diagnosis averaged $10,078 per-person-year (95% ci=$2062-$32,254).Predicted incremental hospitalisation, outpatient, and medication costs were all significantly-greater for the low-ses patients versus high-ses (additional $1922 per-person-year in incremental costs for low-ses).Similar patterns were observed when restricting to those followed the full five-years after index date.Conclusion even in a single-payer, publicly-funded healthcare setting, low ses at sle diagnosis was associated with significantly-greater direct medical costs for the management of sle and associated complications.

Journal: Seminars in arthritis and rheumatism (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't