syedzayyan/paper_mill_benchmark huggingface dataset:
The Relationship Between Neighborhood Disadvantage and Kidney Disease Progression in the Chronic Kidney Disease in Children (CKiD) Cohort.

Rationale & objective to examine the relationship between neighborhood poverty and deprivation, chronic kidney disease (ckd) comorbidities, and disease progression in children with ckd.Study design observational cohort study.Setting & participants children with mild to moderate ckd enrolled in the cki d (chronic kidney disease in children) study with available us census data.Exposure neighborhood poverty and neighborhood disadvantage.Outcome binary outcomes of short stature, obesity, hypertension, and health care utilization for cross-sectional analysis; a ckd progression end point (incident kidney replacement therapy [krt] or 50% loss in estimated glomerular filtration rate), and mode of first krt for time-to-event analysis.Analytical approach cross-sectional analysis of health characteristics at time of first census data collection using logistic regression to estimate odds ratios.Risk for ckd progression was analyzed using a cox proportional hazard model.Multivariable models were adjusted for race, ethnicity, sex, and family income.Results there was strong agreement between family and neighborhood socioeconomic characteristics.Risk for short stature, hospitalization, and emergency department (ed) use were significantly associated with lower neighborhood income.After controlling for race, ethnicity, sex, and family income, the odds of hospitalization (or, 1.71 [95% ci, 1.08-2.71]) and ed use (or, 1.56 [95% ci, 1.02-2.40]) remained higher for those with lower neighborhood income.The hazard ratio of reaching the ckd progression outcome for participants living in lower income neighborhoods was significantly increased in the unadjusted model only (1.38 [95% ci, 1.02-1.87]).Likelihood of undergoing a preemptive transplant was decreased with lower neighborhood income (or, 0.47 [95% ci, 0.24-0.96]) and higher neighborhood deprivation (or, 0.31 [95% ci, 0.10-0.97]), but these associations did not persist after controlling for participant characteristics.Limitations limited generalizability, as only those with consistent longitudinal nephrology care were studied.Conclusions neighborhood-level socioeconomic status (ses) was associated with poorer health characteristics and ckd progression in univariable analysis.However, the relationships were attenuated after accounting for participant-level factors including race.A persistent association of neighborhood poverty with hospitalizations and ed suggests an independent effect of ses on health care utilization, the causes for which deserve additional study.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation (2022)
Publication types: Journal Article;Observational Study;Research Support, N.I.H., Extramural
Subcutaneous Allergen Immunotherapy in Children: Real Life Compliance and Effect of COVID-19 Pandemic on Compliance.

Subcutaneous allergen immunotherapy (scit) is an effective treatment for allergic rhinitis, asthma, and venom allergy.Compliance is essential for scit to obtain maximal benefit as it is a long-term treatment.Objectives this study aimed to determine the level of real-life scit compliance in pediatric patients and the associated factors.Additional aims were to determine how scit compliance was affected by the covid-19 pandemic and why some patients dropped out scit.Method pediatric patients diagnosed with allergic rhinitis, allergic asthma, or venom allergy that received scit between september 2012 and july 2020 were analyzed.Results the study included 201 children (66.7% male) with a median (interquartile range) age of 12.8 years (9.4-15.2) at the time of the first scit injection.The overall compliance rate before covid-19 pandemic was 86.1%.Short scit follow-up time and venom anaphylaxis were found to be risk factors for drop out.The leading causes of drop outs were moving to another city/country (32.1%), symptom improvement (17.8%), treatment ineffectiveness (14.2%), and adverse reactions (14.2%).Among the 108 patients that were still receiving scit during the covid-19 pandemic, 31 (28.7%) dropped out the therapy.The most frequent reasons for drop-out were fear of being infected with covid-19 (35.4%) and thinking that the ait practise stopped due to covid-19 pandemic (29%).Male gender and older age were found to be the independent risk factors for drop-out of scit.Conclusions real life compliance in children was found 13.9% and it was higher than adults.Nearly one-third of children dropped out during the co-vid-19 pandemic.Male gender and older age are associated with scit drop-out during the covid-19 pandemic.

Journal: International archives of allergy and immunology (2021)
Publication types: Journal Article
Construction of precious metal-loaded BiOI semiconductor materials with improved photocatalytic activity for microcystin-LR degradation.

The composite photocatalyst of precious metal loaded on bi oi (m/bi oi, m = pt, au, ag) was prepared by photochemical deposition and used for the photocatalytic degradation of microcystins (mc-lr).The material was characterized by x-ray powder diffraction (xrd), field emission scanning electron microscopy (fesem), ultraviolet visible (uv-vis) diffuse reflectance spectroscopy, x-ray photoelectron spectroscopy (xps), and photoluminescence spectra (pl).The effect of photodegradation of mc-lr and the possible mechanism were investigated.It turned out that, among precious metals of pt, au, and ag, ag had the most significant improvement for photocatalytic activity of bi oi and au was the least.The ag/bi oi catalyst was illuminated 2 h under the simulated visible-light condition with the optimal load ratio of ag catalyst (1.0 wt%) and the 2-h illumination under simulated visible-light condition, the degradation rate of mc-lr was 61.26% ± 0.12%.In addition, through the experiment of trapping agent and the analysis of electron spin resonance (esr), we could conclude that the main active species is o2-in the process of the degradation of mc-lr by three precious metal-loaded bi oi semiconductor materials.

Journal: Environmental science and pollution research international (2019)
Publication types: Journal Article
Total Endovascular Repair of a Juxta-vertebral Subclavian Artery Pseudoaneurysm and Flow Preservation of a Dominant Vertebral Artery Using Parallel Stent Grafts.

The endovascular repair of subclavian aneurysms or pseudoaneurysms is now widely adopted.However, controversies still prevail in the management of dominant vertebral arteries originating close to aneurysms, as coverage of the vertebral artery might be complicated by either endoleaks or ischemic events.Here, we present a rare case of multiple aneurysmal lesions involving the right subclavian artery and bilateral internal carotid arteries treated by way of a total endovascular method using parallel stent grafts for the simultaneous exclusion of a subclavian artery pseudoaneurysm and flow preservation of the adjacent vertebral artery.To the best of our knowledge, this is the first study to report the use of this technique for the endovascular repair of juxta-vertebral subclavian artery pseudoaneurysms.

Journal: Annals of vascular surgery (2020)
Publication types: Case Reports;Journal Article
MRI Features of Solitary Vertebral Masses in Dogs: 20 Cases (2010-2019).

The objective of the study was to describe the mri features of cytologically or histologically diagnosed solitary vertebral masses in dogs and identify potential mri features enabling differentiation between malignant and benign lesions.Patients were divided into malignant and benign groups according to the final diagnosis.Medical records and mri studies were retrospectively reviewed, and specific imaging features were compared.The malignant group comprised 15 dogs, with 5 dogs included in the benign group.Mri features of the different histopathologic/cytologic types of masses are described.Involvement of the vertebral body, a hyperintense signal on t2-weighted, short tau inversion recovery, t1-weighted, and t1-weighted gradient echo sequences and evidence of cortical destruction were signifi-cantly associated with malignancy (p < .05).Hypointensity on t1-weighted gradient echo sequence was significantly associated with benign masses (p < .05).The presence of bone sclerosis was significantly associated with osteosarcomas compared with other malignant masses (p < .05).Fractures (5 cases) were only seen in the group of malignant masses.This pilot study identifies some mri features that may help differentiate between malignant and benign solitary vertebral masses.Greater case numbers are needed in future studies.

Journal: Journal of the American Animal Hospital Association (2021)
Publication types: Journal Article
Urine metabolomics analysis of sleep quality in deep-underground miners: A pilot study.

In previous questionnaire surveys of miners, sleep disorders were found among underground workers.The influence of the special deep-underground environment and its potential mechanism are still unclear.Therefore, this study intends to utilize lc-ms metabolomics to study the potential differences between different environments and different sleep qualities.Methods twenty-seven miners working at 645-1,500 m deep wells were investigated in this study, and 12 local ground volunteers were recruited as the control group.The pittsburgh sleep quality index (psqi) was used to examine and evaluate the sleep status of the subjects in the past month, and valuable basic information about the participants was collected.Psqi scores were obtained according to specific calculation rules, and the corresponding sleep grouping and subsequent analysis were carried out.Through liquid chromatography-mass spectrometry (lc-ms) non-targeted metabolomics analysis, differences in metabolism were found by bioinformatics analysis in different environments.Results between the deep-underground and ground (duvs g) group, 316 differential metabolites were identified and 125 differential metabolites were identified in the good sleep quality vs.Poor sleep quality (gsqvs psq) group.The metabolic pathways of phenylalanine, tyrosine and tryptophan biosynthesis (p= 0.0102) and d-glutamine and d-glutamate metabolism (p= 0.0241) were significantly enriched in duvs g.For gsqvs psq group, butanoate metabolism was statistically significant (p= 0.0276).L-phenylalanine, l-tyrosine and l-glutamine were highly expressed in the deep-underground group.Acetoacetic acid was poorly expressed, and 2-hydroxyglutaric acid was highly expressed in good sleep quality.Conclusions the influence of the underground environment on the human body is more likely to induce specific amino acid metabolism processes, and regulate the sleep-wake state by promoting the production of excitatory neurotransmitters.The difference in sleep quality may be related to the enhancement of glycolytic metabolism, the increase in excitatory neurotransmitters and the activation of proinflammation.L-phenylalanine, l-tyrosine and l-glutamine, acetoacetic acid and 2-hydroxyglutaric acid may be potential biomarkers correspondingly.

Journal: Frontiers in public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Benchmarking Monte-Carlo dose calculation for MLC CyberKnife treatments.

Vendor-independent monte carlo (mc) dose calculation (idc) for patient-specific quality assurance of multi-leaf collimator (mlc) based cyber knife treatments is used to benchmark and validate the commercial mc dose calculation engine for mlc based treatments built into the cyber knife treatment planning system (precision mc).Methods the benchmark included dose profiles in water in 15 mm depth and depth dose curves of rectangular mlc shaped fields ranging from 7.6 mm × 7.7 mm to 115.0 mm × 100.1 mm, which were compared between idc, precision mc and measurements in terms of dose difference and distance to agreement.Dose distributions of three phantom cases and seven clinical lung cases were calculated using both idc and precision mc.The lung ptvs ranged from 14 cm3to 93 cm3.Quantitative comparison of these dose distributions was performed using dose-volume parameters and 3d gamma analysis with 2% global dose difference and 1 mm distance criteria and a global 10% dose threshold.Time to calculate dose distributions was recorded and efficiency was assessed.Results absolute dose profiles in 15 mm depth in water showed agreement between precision mc and idc within 3.1% or 1 mm.Depth dose curves agreed within 2.3% / 1 mm.For the phantom and clinical lung cases, mean ptv doses differed from - 1.0 to + 2.3% between idc and precision mc and gamma passing rates were > =98.1% for all multiple beam treatment plans.For the lung cases, lung v20 agreed within ±1.5%.Calculation times ranged from 2.2 min (for 39 cm3ptv at 1.0 × 1.0 × 2.5 mm3native ct resolution) to 8.1 min (93 cm3at 1.1 × 1.1 × 1.0 mm3), at 2% uncertainty for precision mc for the 7 examined lung cases and 4-6 h for idc, which, however, is not optimized for efficiency but used as a gold standard for accuracy.Conclusions both accuracy and efficiency of precision mc in the context of mlc based planning for the cyber knife m6 system were benchmarked against mc based idc framework.Precision mc is used in clinical practice at our institute.

Journal: Radiation oncology (London, England) (2019)
Publication types: Journal Article
Non-canonical Wnt signaling participates in Jagged1-induced osteo/odontogenic differentiation in human dental pulp stem cells.

Osteoblast differentiation requires the interaction of various cell signaling pathways to modulate cell responses.Notch and wnt signaling are among the crucial pathways that control numerous biological processes, including osteo/odontogenic differentiation.The aim of the present study was to examine the involvement of wnt signaling in the jagged1-induced osteo/odontogenic differentiation in human dental pulp stem cells (h dpscs).The wnt-related gene expression was analyzed from publicly available data of jagged1-treated human dental pulp cells.The m rna expression of wnt ligands (wnt2b, wnt5a, wnt5b, and wnt16) and wnt inhibitors (dkk1, dkk2, and sost) were confirmed using real-time polymerase chain reaction.Among the wnt ligands, wnt2b and wnt5a m rna levels were upregulated after jagged1 treatment.In contrast, the wnt inhibitors dkk1, dkk2, and sost m rna levels were downregulated.Recombinant wnt5a, but not wnt2b, significantly promoted in vitro mineral deposition by h dpscs.Wnt signaling inhibition using iwp-2, but not dkk1, inhibited jagged1-induced alkaline phosphatase (alp) activity, mineralization, and osteo/odontogenic marker gene expression in h dpscs.In conclusion, jagged1 promoted h dpsc osteo/odontogenic differentiation by modulating the non-canonical wnt pathway.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Treatment patterns and decision drivers to discharge patients with depression hospitalised for acute suicidal ideation in Europe.

There is limited published information about the management of patients with major depressive disorder (mdd) hospitalised for acute suicidal ideation (si).This study aimed to identify treatment patterns and unmet needs in the management of these patients and the decision drivers for hospital discharge.Methods cross-sectional survey-based study enrolling hospital-based european psychiatrists.The study had a qualitative and a quantitative stage, including a conjoint exercise.Results each respondent (n = 413) managed, on average, 62 mdd patients with acute si per typical three-month period; 76% of these patients required hospitalisation.Severity of si and severity of mdd were considered the most important factors for hospital admission and discharge.In the conjoint analysis, these attributes accounted for 54% of the discharge decision.Key treatment goals included improving depressive symptoms and achieving mdd remission.Antidepressants were a standard treatment for 98% of respondents but 63% defined rapid onset of action as a critical unmet need, followed by a good tolerability profile (34%).Limitations the study has a cross-sectional design representing respondents' behaviour and attitudes at a particular point in time.In the conjoint analysis, the results represent stated behaviour and not observed clinical behaviour.Conclusions physicians' decisions to admit and discharge patients with mdd hospitalised for acute si are mostly driven by the severity of si and depression.Antidepressants with rapid onset of action, which can quickly improve depressive symptoms, represent a key unmet need for these patients and may contribute to a higher likelihood of early discharge.

Journal: Journal of affective disorders (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Predictors of hospitalization and surgical intervention among patients with motorcycle injuries.

To describe the distribution of injuries, hospitalization rates by body areas injured, and surgery-requiring admissions, and to identify independent predictors of admission to a regional hospital in jamaica.Methods a cross-sectional study was conducted among persons presenting to the st ann's bay regional hospital in jamaica (2016-2018) with injuries sustained from motorcycle crashes.A census was done of patients admitted to the surgery ward from the emergency room, as well as those referred to the orthopaedic outpatient department.Trained members of the orthopedic team administered a pretested questionnaire within 24 hours of presenting to the orthopedic service to elicit data on sociodemographic characteristics, motor vehicle collision circumstance and motor bike specifications, physical injuries sustained and medical management, as well as compliance with legal requirements for riding a motorcycle.Associations between variables were examined using χ2tests and logistic regression.Results there were 155 participants in the study, and 75.3% of motorcyclists with injuries required admission.The average length of stay was approximately 10 days.Surgery was required for 71.6% of those admitted.Lower limb injuries constituted 55% of all injuries.The independent predictors for admission were alcohol use and total body areas involved.Motorcycle crash victims who used alcohol close to the time of crash were three times more likely to be admitted to hospital than those who did not consume alcohol.As the total body areas involved increased by one, there was a threefold increase in the likelihood of being admitted.Additionally, the greater the number of body areas involved, the greater was the likelihood of admission.Discussion lower limb injuries are the most commonly reported injuries among victims of motorcycle crashes.Alcohol and total body areas involved are independent predictors of admission to hospital.In the planning of trauma delivery services, this information should be taken into account.Level of evidence level iv.

Journal: Trauma surgery & acute care open (2019)
Publication types: Journal Article
Performance After Concussion in National Basketball Association Players.

Concussions have received national attention in collision sports such as football, soccer, and hockey, but less focus has been placed on basketball.Purpose to determine return-to-play (rtp) and player performance in the first and second season after concussion in national basketball association (nba) players.Study design descriptive epidemiology study.Methods an online database of publicly available nba athlete injuries was queried for instances of "concussion" between 2010 and 2018.The age at injury, team, position, height, weight, body mass index, nba experience, date of concussion, date of return, and seasons played postconcussion was recorded for each player.Regular-season statistics (games started, games played, minutes played, and player efficiency rating [per]) were compiled for the season before, and 2 seasons immediately after, injury.Kaplan-meier survivorship plots were computed for athlete rtp and retirement endpoints.Results a total of 81 injuries were identified from 2010 to 2018, with a rate of 2.0 concussions per 100 player-years.Overall rtp was 100% after concussion, with nearly all (88%) returning in the season of injury; 12% of players experienced a season-ending concussion.Rtp averaged 37.3 days after injury, varying widely (range, 2-291 days).Compared with preinjury season (78.0%), athletes played in significantly fewer overall games in the season of injury (36.6%;p< .0001), as well as 1 (69.5%;p= .0229) and 2 seasons postinjury (73.2%;p= .3192).Per scores were not significantly different across the study period.Each point increase in a player's preinjury per score was associated with a 2.4% decrease in per from the preinjury season to season of injury (p= .0016) and a 3.1% decrease from preinjury to season after injury (p= .0053).Each increasing year of age or year of experience was associated with 5% decline in per score at 1 season after injury.Conclusion nba players had a high rtp after concussion, with most returning in the same season as the injury.Players sustaining concussions played significantly fewer games for at least 2 seasons after injury.Performance via per did not change across the entire cohort; however, players with higher preinjury per, and older players were more likely to sustain a greater decline in performance after injury.

Journal: Orthopaedic journal of sports medicine (2022)
Publication types: Journal Article
Reversible Takotsubo Syndrome Complicated With Acute Thromboembolic Stroke Co-Occurring With Cola-Induced Severe Hypokalemia.

Takotsubo syndrome (tts) is a poorly understood phenomenon that manifests as reversible myocardial damage.Despite the overall benign course of tts, acute complications and significant mortality and morbidity are frequently encountered.However, the risk factors for developing such complications are not well determined.We present a case of reversible tts within 48 hours after correction of cola-induced hypokalemia complicated by thromboembolic stroke.We present the patient's clinical presentation with imaging studies and discuss the case in light of related literature.A 62-year-old woman with a longstanding history of inadequate oral intake and excessively sweetened cola soft drinks consumption.Presented with progressive symmetrical quadriparesis and found to have severe hypokalemia with rhabdomyolysis, elevated troponin, and acute left ventricular dysfunction.The patient was diagnosed with tts and hypokalemic paralysis.Her hospital course was complicated with an acute thromboembolic stroke of bilateral occipital lobes and left cerebellum.Takotsubo cardiomyopathy was reversible 48 hours after correction of severe hypokalemia.Cardiac ischemic workup was negative for any evidence of myocardial ischemia.In this presented case, tts was revisable within 48 hours after the correction of cola-induced hypokalemia.However, patients with similar presentations might have a higher risk for in-hospital thromboembolic complications of tts.

Journal: Cureus (2021)
Publication types: Case Reports;Journal Article