syedzayyan/paper_mill_benchmark huggingface dataset:
Giant piezoresistive effect by optoelectronic coupling in a heterojunction.

Enhancing the piezoresistive effect is crucial for improving the sensitivity of mechanical sensors.Herein, we report that the piezoresistive effect in a semiconductor heterojunction can be enormously enhanced via optoelectronic coupling.A lateral photovoltage, which is generated in the top material layer of a heterojunction under non-uniform illumination, can be coupled with an optimally tuned electric current to modulate the magnitude of the piezoresistive effect.We demonstrate a tuneable giant piezoresistive effect in a cubic silicon carbide/silicon heterojunction, resulting in an extraordinarily high gauge factor of approximately 58,000, which is the highest gauge factor reported for semiconductor-based mechanical sensors to date.This gauge factor is approximately 30,000 times greater than that of commercial metal strain gauges and more than 2,000 times greater than that of cubic silicon carbide.The phenomenon discovered can pave the way for the development of ultra-sensitive sensor technology.

Journal: Nature communications (2019)
Publication types: Journal Article
Interprofessional collaboration in the renal care settings: Experiences in the COVID-19 era.

The role of interprofessional collaboration (ipc) in healthcare is increasingly emphasized.Due to significant comorbidity in renal patients who require highly specialized procedures, proper ipc is an essential component in renal care.During the coronavirus disease 2019 (covid-19) pandemic, the existing and proven collaboration mechanisms were put to the test.Objectives to assess ipc in the renal care settings in the era of covid-19 pandemic.Material and methods the survey consisted of the assessment of interprofessional team collaboration scale ii (aitcs-ii) (3 subscales - partnership, cooperation and coordination, maximum of 5 points), questions about work conditions and factors influencing work during the pandemic, as well as demographic data.The survey was distributed in 8 renal care settings (4 hospital wards with dialysis units and 4 individual dialysis units); 127 participants filled out the survey; 26.8% of participants were physicians, 68.5% nurses and 4.7% other staff members, i.e., administrative assistants.Mean work experience in their current team was 16.8 ±11.7 years among nurses and 11.6 ±9.7 years among physicians.Results interprofessional collaboration was assessed by physicians and nurses, respectively, as follows: partnership 4.03 ±0.79 compared to 3.58 ±0.73 (p = 0.003), cooperation 4.28 ±0.59 compared to 3.71 ±0.72 (p = 0.0002), and coordination 3.83 ±0.87 compared to 3.48 ±0.82 (p = 0.04).The specific workplace did not influence the ipc rates; 49.9% of physicians and 40.1% of nurses agreed or strongly agreed that the collaboration worsened during the pandemic; 47% of physicians and 42.4% of nurses admitted that the communication has significantly deteriorated.An increased level of stress, new procedures and fear of getting infected with severe acute respiratory syndrome coronavirus 2 (sars-co v-2) were, according to the participants, the most significant factors for the worsening of ipc.Conclusions the exceptional circumstances faced during the pandemic have a significant impact on ipc, which may influence patients' satisfaction and safety.An active support for healthcare teams in the field of ipc is especially important in this challenging reality.

Journal: Advances in clinical and experimental medicine : official organ Wroclaw Medical University (2022)
Publication types: Journal Article
Choosing Sides: Impact of Prismatic Adaptation on the Lateralization of the Attentional System.

Seminal studies revealed differences between the effect of adaptation to left- vs.Right-deviating prisms (l-pa, r-pa) in normal subjects.Whereas l-pa leads to neglect-like shift in attention, demonstrated in numerous visuo-spatial and cognitive tasks, r-pa has only minor effects in specific aspects of a few tasks.The paucity of r-pa effects in normal subjects contrasts with the striking alleviation of neglect symptoms in patients with right hemispheric lesions.Current evidence from activation studies in normal subjects highlights the contribution of regions involved in visuo-motor control during prism exposure and a reorganization of spatial representations within the ventral attentional network (van) after the adaptation.The latter depends on the orientation of prisms used.R-pa leads to enhancement of the ipsilateral visual and auditory space within the left inferior parietal lobule (ipl), switching thus the dominance of van from the right to the left hemisphere.L-pa leads to enhancement of the ipsilateral space in right ipl, emphasizing thus the right hemispheric dominance of van.Similar reshaping has been demonstrated in patients.We propose here a model, which offers a parsimonious explanation of the effect of l-pa and r-pa both in normal subjects and in patients with hemispheric lesions.The model posits that prismatic adaptation induces instability in the synaptic organization of the visuo-motor system, which spreads to the van.The effect is lateralized, depending on the side of prism deviation.Successful pointing with prisms implies reaching into the space contralateral, and not ipsilateral, to the direction of prism deviation.Thus, in the hemisphere contralateral to prism deviation, reach-related neural activity decreases, leading to instability of the synaptic organization, which induces a reshuffling of spatial representations in ipl.Although reshuffled spatial representations in ipl may be functionally relevant, they are most likely less efficient than regular representations and may thus cause partial dysfunction.The former explains, e.g., the alleviation of neglect symptoms after r-pa in patients with right hemispheric lesions, the latter the occurrence of neglect-like symptoms in normal subjects after l-pa.Thus, opting for r- vs.L-pa means choosing the side of major ipl reshuffling, which leads to its partial dysfunction in normal subjects and to recruitment of alternative or enhanced spatial representations in patients with hemispheric lesions.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article;Review
Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants.

We recently published a preliminary assessment of the activity of a poly (adp-ribose) polymerase (parp) inhibitor, stenoparib, also known as 2x-121, which inhibits viral replication by affecting pathways of the host.Here we show that stenoparib effectively inhibits a sars-co v-2 wild type (bav pat1/2020) strain and four additional variant strains; alpha (b.1.1.7), beta (b.1.351), delta (b.1.617.2) and gamma (p.1) in vitro, with 50% effective concentration (ec50) estimates of 4.1 μm, 8.5 μm, 24.1 μm, 8.2 μm and 13.6 μm, respectively.A separate experiment focusing on a combination of 10 μm stenoparib and 0.5 μm remdesivir, an antiviral drug, resulted in over 80% inhibition of the alpha variant, which is substantially greater than the effect achieved with either drug alone, suggesting at least additive effects from combining the different mechanisms of activity of stenoparib and remdesivir.

Journal: PloS one (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
SMA-10 Is a Non-Canonical Member of the TGF-β Sma/Mab Pathway and Immunity Regulator via the DAF-2 Insulin Receptor inCaenorhabditis elegans.

Transforming growth factor β (tgf-β) signalling pathways are highly conserved across metazoa and play essential roles not only during development but also in adult tissue maintenance.Alterations of these pathways usually result in a plethora of pathologies.In the nematode caenorhabditis elegans, the tgf-β sma/mab (small/male abnormal) pathway regulates various worm phenotypes such as body size, immune response, ageing, matricide and reproductive span.Sma-10 has been described as a positive modulator of worm body size through the tgf-β sma/mab pathway.To better understand if sma-10 is a core component of the pathway, we use gene epistatic analysis to assess the contribution of sma-10 to various phenotypes regulated by tgf-β sma/mab.We confirm that sma-10 controls body size and find that it also affects the matricide and reproductive span of the nematodes.However, neither male tail formation (previously reported) nor ageing appeared altered.Lastly, although nullsma-10worms are more susceptible to pseudomonas aeruginosainfections than wild-types, this response does not depend on tgf-β sma/mab but on the insulin receptor daf-2.We also show that the expression ofsma-10in either hypodermis or intestine fully rescues the wild-type immune response.Our results contribute to understanding the role of sma-10 as a context-dependent component of tgf-β sma/mab, and reveal a function of sma-10 in immunity in association to the insulin/insulin-like growth factor signalling (iis) pathway.

Journal: International journal of molecular sciences (2021)
Publication types: Journal Article
Stamplike flexible SERS substrate for in-situ rapid detection of thiram residues in fruits and vegetables.

A simple and sensitive surface-enhanced raman spectroscopy (sers) method for the detection of thiram residues in fruit and vegetable peels is reported.A flexible sers substrate based on silver nanoparticles in an agar gel has been developed and characterised.Peels of different fruits and vegetables were intentionally contaminated with different amounts of thiram.The analyte was then extracted within few seconds by gentle rubbing the surface with the agar substrate using it as a stamp.The optimum experimental conditions of the developed method were explored.The limit of detection of thiram in the peels of tomato and green pepper was 140 pg/cm2.The values achieved for apple was 2 pg/cm2.The method presented could be extensively used for the detection of traces of other contaminants on food surfaces and for other relevant applications.

Journal: Food chemistry (2022)
Publication types: Journal Article
Galectin-1 alleviates myocardial ischemia-reperfusion injury by reducing the inflammation and apoptosis of cardiomyocytes.

Myocardial ischemia-reperfusion injury (miri) is one of the leading causes of morbidity and mortality worldwide, for which there is no effective treatment.The present study aimed to assess novel methods of clinical miri treatment by studying the effects of galectin-1 (gal-1) on miri.Male 2-month-old sprague dawley rats and the rat cardiomyocyte cell line h9c2 were utilized in the present study.A rat model of miri was constructed by ligating the left anterior descending coronary artery, which was subsequently treated with gal-1.Differences in myocardial injury were then assessed by hematoxylin and eosin (h&e) staining.In addition, the levels of inflammation and apoptosis in rat myocardial tissue were determined by immunohistochemistry staining.Hypoxia-reoxygenation was used to construct a model of miri in h9c2 cells.The effect of gal-1 on the apoptosis and viability of h9c2 cells was also verified by flow cytometry and a cell counting kit-8 assay.The results of h&e staining revealed that gal-1 alleviated miri.Echocardiography demonstrated that gal-1 improved cardiac function in rats following miri.In addition, miri increased levels of inflammation and apoptosis in rat myocardial tissues, with gal-1 treatment reversing this effect.In cellular experiments, gal-1 served anti-inflammatory and anti-apoptotic effects in hypoxic/reoxygenated cardiomyocytes.In conclusion, gal-1 served a significant protective effect on the myocardial tissue after ischemia-reperfusion by reducing the level of inflammation and apoptosis in cardiomyocytes.

Journal: Experimental and therapeutic medicine (2022)
Publication types: Journal Article
Group psychoeducation for persons with bipolar disorder in Rwanda: a study protocol for a randomized controlled trial.

The efficacy of psychoeducation as an add-on treatment to pharmacotherapy is well documented in treating symptoms and in relapse prevention for persons with bipolar disorder in western countries.Yet, no studies on psychosocial interventions for persons with bipolar disorder have been conducted in a low-income country in africa.Aim to develop a bipolar group psychoeducation program contextualized to the rwandese setting, and determine its effect on symptom severity, medical adherence, and internalized stigma.Methods a culturally adapted guide manual was developed by local mental health professionals, including nurses, psychologists, and medical doctors.In-depth interviews with participants were held prior to and will be held following the intervention to address the cultural aspect of living with bipolar disease and the impact of the program.A two-armed randomized controlled trial has been set up at the tertiary mental health hospitals in rwanda, with an intervention and a waiting list arm.A sample size of at least 50 in each arm was calculated as a requirement.The study's primary outcome measure will be the difference in relapse rate measured on the young mania rating scale and hamilton depression scale-17.Differences in mean change on scales for medical adherence and internalized stigma will be secondary outcomes.Data will be analyzed according to the intention-to-treat principle.Participants will be assessed subsequently at baseline, at the end of the intervention period, and three months and 12 months post-intervention.Discussion this study will be one of the first intervention trials on bipolar disorder in a low-income country.If proven successful in reducing morbidity and increasing the quality of life in persons with bipolar disorder, it is anticipated that the psychoeducation program can be implemented at the district and community level and act as inspiration for other low-resource settings.Trial registration clinical trials.gov nct04671225.Registered on november 2020.

Journal: Trials (2022)
Publication types: Clinical Trial Protocol;Journal Article
Mutagenic repair of a ZFN-induced double-strand break in yeast: Effects of cleavage site sequence and spacer size.

Double-strand breaks are repaired by error-free homologous recombination or by relatively error-prone pathways that directly join broken ends.Both types of repair have been extensively studied in saccharomyces cerevisiae using enzymes ho or i-sce i, which create breaks with 4-nt 3' overhangs.In the current study, a galactose-regulated zinc-finger nuclease (zfn) designed to cleave the drosophila rosy locus was used to generate breaks with 4-nt 5' overhangs at out-of-frame cleavage sites inserted into the yeast lys2 gene.Mutagenic repair was examined following selection of prototrophs on lysine-deficient medium containing galactose or surviving colonies on galactose-containing rich medium.Following cleavage of the original rosy spacer (acgaat), most lys+colonies contained 1- or 4-bp insertions at the cleavage site while most survivors had either a 2-bp insertion or a large deletion.Small insertions reflected nonhomologous end joining (nhej) and large deletions were the product of microhomology-mediated end joining (mmej).Changing the original acgaat spacer to either agcaat, acgcgt or ctatta altered the molecular features of nhej events as well as their frequency relative to mmej.Altering the optimal 6-bp spacer size between the zinc-finger protein binding sites to 5 bp or 7 bp eliminated the effect of continuous zfn expression on survival, but lys+prototrophs were still generated.Analysis of lys+revertants after cleavage of the 5-bp spacer indicated that both the position and spacing of zfn-generated nicks were variable.Results provide insight into effects of overhang sequence on mutagenic outcomes and demonstrate zfn cleavage of 5- or 7-bp spacers in vivo.

Journal: DNA repair (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Psychometric properties and normative values of the revised demoralization scale (DS-II) in a representative sample of the German general population.

Demoralization is a clinically relevant syndrome in chronic diseases.The demoralization scale (ds-ii) was recently developed as an economic screening tool in clinical populations.Main aim of this study was to provide normative data of ds-ii scores in the general population.Methods we developed a new german version, the ds-ii münster, and tested internal consistency as well as the previously proposed two-factor structure with confirmatory factor analyses.The ds-ii was applied in a household survey of the general population.Associations between ds-ii scores and age, gender and other sociodemographic variables were explored.Results the final sample consisted of n = 2471 participants (mean age = 49.8 years, range: 18-96; 50.1% men, 49.8% women).The ds-ii münster showed nearly excellent internal consistency.The model fit indices of the two-factor structure were not superior to those of the one-factor model.Mean scores of the ds-ii were as follows.Total score: m = 3.76 (sd = 5.56), meaning and purpose subscale: m = 1.65 (sd = 2.77), distress and coping ability subscale: m = 2.11 (sd = 3.02).Ds-ii scores were increased in women with an effect size of cohen's d = 0.19.An age-related increase was specifically found for the meaning and purpose subscale (d = 0.21).Conclusions the study provides normative values of the ds-ii with respect to age and gender in the general population to facilitate interpretation of ds-ii scores in clinical samples.A ds-ii total score > 5 is suggested as a cut-off value.The findings further our understanding of significant symptom burden that was previously suggested in young patients with cancer.

Journal: BMC psychiatry (2023)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Prepectoral breast reconstruction: an ideal approach to bilateral risk-reducing mastectomy.

Bilateral risk-reducing mastectomy (brrm) has increased its popularity in the last years because of its aim to minimise the chances of developing breast cancer in high-risk patients.Women undergoing this procedure must be considered highly demanding patients given the need to combine aesthetical, functional and preventive desires.This study aims to present the authors' experience in performing brrm followed by single-stage prepectoral reconstruction (ppbr) with implant completely covered by acellular dermal matrix (adm) and to report indications, surgical techniques, functional and aesthetic results.Methods a single-centre prospective data collection was carried out from january 2017 to january 2021 of patients at high risk of developing breast cancer undergoing brrm and immediate ppbr with adm.Patients were subdivided into two groups according to the breast shape: group a had small and medium size breasts and group b had large and ptotic breasts.Oncological and surgical outcomes were collected.Satisfaction with reconstruction and related quality of life were evaluated through the breast-q questionnaire.Results a total of twenty-three patients met the inclusion criteria.Seventeen patients were included in group a and six patients in group b.Average follow-up was 18.4 months.Minor complications occurred in four breasts: one seroma, one hematoma and two cases of wound dehiscence.Capsular contracture was not observed.All patients were satisfied with the final result according to the post-operative breast-q questionnaire.Conclusions immediate prepectoral breast reconstruction could represent the ideal reconstruction option after brrm and should be offered to all women that fulfil the inclusion criteria.

Journal: Gland surgery (2021)
Publication types: Journal Article
Rapid degradation of p-arsanilic acid and simultaneous removal of the released arsenic species by Co-Fe@C activated peroxydisulfate process.

In this study, a bimetallic composite catalyst (co-fe@c) was fabricated with calcination at high temperature (800 °c) by using co-mil-101 (fe) as the precursor.The characterization results showed that the resulted co-fe@c composite mainly consisted of carbon, fe co alloys, fe3o4, co3o4and fe o, and owned evident magnetism.In addition, the co-fe@c was employed to activate the peroxydisulfate (pds) to degrade a representative organic pollutant (p-arsanilic acid, p-asa) and the main factors were optimized, which involved 0.2 g l-1of catalyst dosage, 1.0 g l-1of pds dosage and 5.0 of initial p h.Under the optimal condition, co-fe@c/pds system could completely degrade p-asa (20 mg l-1) in 5 min.In the co-fe@c/pds system, so4-·, fe(iv) and ·oh were the main species during p-asa degradation.Under the attack of these species, p-asa was first decomposed into phenols and then transformed into the organics acids and finally mineralized into co2and h2o through a series of reactions like hydroxylation, dearsenification, deamination and benzene ring opening.Importantly, most of the released inorganic arsenic species (93.40%) could be efficiently adsorbed by the catalyst.

Journal: Environmental research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Dynamic prediction of mortality in COVID-19 patients in the intensive care unit: A retrospective multi-center cohort study.

The covid-19 pandemic continues to overwhelm intensive care units (icus) worldwide, and improved prediction of mortality among covid-19 patients could assist decision making in the icu setting.In this work, we report on the development and validation of a dynamic mortality model specifically for critically ill covid-19 patients and discuss its potential utility in the icu.Methods we collected electronic medical record (emr) data from 3222 icu admissions with a covid-19 infection from 25 different icus in the netherlands.We extracted daily observations of each patient and fitted both a linear (logistic regression) and non-linear (random forest) model to predict mortality within 24 h from the moment of prediction.Isotonic regression was used to re-calibrate the predictions of the fitted models.We evaluated the models in a leave-one-icu-out (loio) cross-validation procedure.Results the logistic regression and random forest model yielded an area under the receiver operating characteristic curve of 0.87 [0.85; 0.88] and 0.86 [0.84; 0.88], respectively.The recalibrated model predictions showed a calibration intercept of -0.04 [-0.12; 0.04] and slope of 0.90 [0.85; 0.95] for logistic regression model and a calibration intercept of -0.19 [-0.27; -0.10] and slope of 0.89 [0.84; 0.94] for the random forest model.Discussion we presented a model for dynamic mortality prediction, specifically for critically ill covid-19 patients, which predicts near-term mortality rather than in-icu mortality.The potential clinical utility of dynamic mortality models such as benchmarking, improving resource allocation and informing family members, as well as the development of models with more causal structure, should be topics for future research.

Journal: Intelligence-based medicine (2022)
Publication types: Journal Article