syedzayyan/paper_mill_benchmark huggingface dataset:
Incidence of Carpal Tunnel Syndrome Requiring Surgery May Increase in Patients Treated with Trigger Finger Release: A Retrospective Cohort Study.

The correlation between carpal tunnel syndrome (cts) surgery and trigger finger (tf) surgery is unclear; we conducted this nationwide population-based study to assess the development of severe cts requiring surgery after tf surgery.Patients and methods this retrospective cohort study used the data of patients diagnosed as having tf between january 1, 2001, and december 31, 2017, and they were divided into two comparative groups.Patients who underwent surgical release within 1 year of diagnosis were included in the tf-op group, and those who did not undergo tf release during the same period were included in the tf-nop group.The primary outcome was the new incidence of cts release (ctr), and data on the related risk factors were collected for analysis.Results a total of 8232 patients each were enrolled into the tf-op and tf-nop groups and were 1:1 propensity score matched (mean patient age, 54.7 ± 10.1 years; mean follow-up duration, 6.58 years).The incidence rate of ctr was 1.1 per 1000 person-years in the tf-op group and 0.7 per 1000 person-years in the tf-nop group.The adjusted hazard ratio of tf surgery was 1.51.The factors significantly correlated with an increased incidence of ctr were age, female sex, diabetes mellitus, and chronic renal failure.In subgroup analysis, patients aged >65 years and female patients in the tf-op group were still at significantly higher risks of ctr than were their counterparts in the tf-nop subgroups.The cumulative incidence of ctr after tf surgery linearly increased with time in both groups.Conclusion patients undergoing tf release may have a higher incidence of ctr 1 year later, especially women and patients aged >65 years.Diabetes mellitus and chronic renal failure may be risk factors.

Journal: Clinical epidemiology (2022)
Publication types: Journal Article
Lipid Alteration Signature in the Blood Plasma of Individuals With Schizophrenia, Depression, and Bipolar Disorder.

Importance no clinically applicable diagnostic test exists for severe mental disorders.Lipids harbor potential as disease markers.Objective to define a reproducible profile of lipid alterations in the blood plasma of patients with schizophrenia (scz) independent of demographic and environmental variables and to investigate its specificity in association with other psychiatric disorders, ie, major depressive disorder (mdd) and bipolar disorder (bpd).Design, setting, and participants this was a multicohort case-control diagnostic analysis involving plasma samples from psychiatric patients and control individuals collected between july 17, 2009, and may 18, 2018.Study participants were recruited as consecutive and volunteer samples at multiple inpatient and outpatient mental health hospitals in western europe (germany and austria [de-at]), china (cn), and russia (ru).Individuals with dsm-iv or international statistical classification of diseases and related health problems, tenth revision diagnoses of scz, mdd, bpd, or a first psychotic episode, as well as age- and sex-matched healthy controls without a mental health-related diagnosis were included in the study.Samples and data were analyzed from january 2018 to september 2020.Main outcomes and measures plasma lipidome composition was assessed using liquid chromatography coupled with untargeted mass spectrometry.Results blood lipid levels were assessed in 980 individuals (mean [sd] age, 36 [13] years; 510 male individuals [52%]) diagnosed with scz, bpd, mdd, or those with a first psychotic episode and in 572 controls (mean [sd] age, 34 [13] years; 323 male individuals [56%]).A total of 77 lipids were found to be significantly altered between those with scz (n = 436) and controls (n = 478) in all 3 sample cohorts.Alterations were consistent between cohorts (cn and ru: [pearson correlation] r = 0.75; de-at and cn: r = 0.78; de-at and ru: r = 0.82; p < 10-38).A lipid-based predictive model separated patients with scz from controls with high diagnostic ability (area under the receiver operating characteristic curve = 0.86-0.95).Lipidome alterations in bpd and mdd, assessed in 184 and 256 individuals, respectively, were found to be similar to those of scz (bpd: r = 0.89; mdd: r = 0.92; p < 10-79).Assessment of detected alterations in individuals with a first psychotic episode, as well as patients with scz not receiving medication, demonstrated only limited association with medication restricted to particular lipids.Conclusions and relevance in this study, scz was accompanied by a reproducible profile of plasma lipidome alterations, not associated with symptom severity, medication, and demographic and environmental variables, and largely shared with bpd and mdd.This lipid alteration signature may represent a trait marker of severe psychiatric disorders, indicating its potential to be transformed into a clinically applicable testing procedure.

Journal: JAMA psychiatry (2023)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Interrogating cell type-specific cooperation of transcriptional regulators in 3D chromatin.

Context-specific activities of transcription regulators (trs) in the nucleus modulate spatiotemporal gene expression precisely.Using the largest ch ip-seq data and chromatin loops in the human k562 cell line, we initially interrogated tr cooperation in 3d chromatin via a graphical model and revealed many known and novel trs manipulating context-specific pathways.To explore tr cooperation across broad tissue/cell types, we systematically leveraged large-scale open chromatin profiles, computational footprinting, and high-resolution chromatin interactions to investigate tissue/cell type-specific tr cooperation.We first delineated a landscape of tr cooperation across 40 human tissue/cell types.Network modularity analyses uncovered the commonality and specificity of tr cooperation in different conditions.We also demonstrated that tr cooperation information can better interpret the disease-causal variants identified by genome-wide association studies and recapitulate cell states during neural development.Our study characterizes shared and unique patterns of tr cooperation associated with the cell type specificity of gene regulation in 3d chromatin.

Journal: iScience (2021)
Publication types: Journal Article
Neutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis.

Stevens-johnson syndrome (sjs) and toxic epidermal necrolysis (ten) are life-threatening mucocutaneous adverse drug reactions characterized by massive epidermal detachment.Cytotoxic t cells and associated effector molecules are known to drive sjs/ten pathophysiology, but the contribution of innate immune responses is not well understood.We describe a mechanism by which neutrophils triggered inflammation during early phases of sjs/ten.Skin-infiltrating cd8+t cells produced lipocalin-2 in a drug-specific manner, which triggered the formation of neutrophil extracellular traps (nets) in early lesional skin.Neutrophils undergoing netosis released ll-37, an antimicrobial peptide, which induced formyl peptide receptor 1 (fpr1) expression by keratinocytes.Fpr1 expression caused keratinocytes to be vulnerable to necroptosis that caused further release of ll-37 by necroptotic keratinocytes and induced fpr1 expression on surrounding keratinocytes, which likely amplified the necroptotic response.The nets-necroptosis axis was not observed in less severe cutaneous adverse drug reactions, autoimmune diseases, or neutrophil-associated disorders, suggesting that this was a process specific to sjs/ten.Initiation and progression of sjs/ten keratinocyte necroptosis appear to involve a cascade of events mediated by innate and adaptive immune responses, and understanding these responses may contribute to the identification of diagnostic markers or therapeutic targets for these adverse drug reactions.

Journal: Science translational medicine (2021)
Publication types: Journal Article;Research Support, N.I.H., Intramural;Research Support, Non-U.S. Gov't
Association of exposure to PM2.5-bound metals with maternal thyroid function in early pregnancy.

Epidemiological evidence linking metals bound to ambient particulate matters with aerodynamic diameter less than 2.5 μm (pm2.5) and maternal thyroid function is limited.In this study, we investigated the association of pm2.5-bound metals with maternal thyroid hormones (th) during the first trimester.We retrospectively reviewed data for 2528 pregnant women attending prenatal care in jinhua maternal and child health care hospital, jinhua, china, from january to december 2018.Information including thyroid hormone levels and demographics was retrieved from existing medical records.We analyzed the concentration of 10 metals for collected particulate samples, and estimated their exposure levels during the first trimester for each woman.We employed multivariate linear regression models to estimate the association of exposure to individual pm2.5-bound metals with serum levels of maternal th, and weighted quantile sum (wqs) to estimate the overall association of exposure to pm2.5-bound metals within a mixture.Higher exposures to most of the pm2.5-bound metals were associated with lower levels of maternal free thyroxine (ft4) and free triiodothyronine (ft3).The thyroid peroxidase antibody (tpoab) or thyroglobulin antibody (tg ab) status had no effect modification on the observed associations.Wqs analyses further suggested that be, ni, tl and ba contributed the most to the associations.These findings highlight the associations of exposure to pm2.5-bound metals with maternal thyroid function, and emphasize the public health significance of commitments to improve air quality.

Journal: The Science of the total environment (2022)
Publication types: Journal Article
Automatic composition of Guzheng (Chinese Zither) music using long short-term memory network (LSTM) and reinforcement learning (RL).

In recent years, with the advance of artificial intelligence, automatic music composition has been demonstrated.However, there are many music genres and music instruments.For a same piece of music, different music instruments would produce different effects.Invented some 2500 years ago, guzheng is one of the oldest music instruments in china and the world.It has distinct timbres and patterns that cannot be duplicated by other music instruments.Therefore, it is interesting to see whether ai can compose guzheng music or alike.In this paper we present a method that can automatically compose and play guzheng music.First, we collect a number of existing guzheng music pieces and convert them into music instrument digital interface format.Second, we use these data to train a long short-term memory (lstm) network and use the trained network to generate new guzheng music pieces.Next, we use the reinforcement learning to optimize the lstm network by adding special guzheng playing techniques.Comparing to the existing ai methods, such as lstm and generative adversary network, our new method is more effective in capturing the characteristics of guzheng music.According to the evaluations from skilled guzheng players and general audiences, our guzheng music is very close to the real guzheng music.The presented method can also be used to automatically compose the music of other chinese music instruments.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Hybridization With an Invasive Plant ofXanthium strumariumImproves the Tolerance of Its Native CongenerX. sibiricumto Cadmium.

Hybridization is one of the important factors influencing the adaptive evolution of invasive plants.According to previous studies, hybridization with an invasive plant reduces the adaptability of its native congener to environment.However, in this study, the hybridization with an invasive plant of xanthium strumarium(lt) improves the tolerance and accumulation of its native congener xanthium sibiricum(cr) to cadmium (cd).Under cd stress,x.Sibiricum♀ ×x.Strumarium♂ (zcr) showed higher biomass and cd accumulation.Compared with cr, zcr has longer vegetative and reproductive growth time.Moreover, zcr adopted more reasonable biomass allocation strategy.Zcr increased the proportion of reproductive allocation and ensured its own survival with the increase of cd stress.Furthermore, zcr increased the translocation of cd to aboveground parts and changed the distribution of cd.A large amount of cd is stored in senescent leaves and eliminated from the plant when the leaves fall off, which not only reduces the cd content in the plant, but also reduces the toxicity of cd in the normal leaves.Transcriptome analysis shows a total of 2055 (1060 up and 995 down) differentially expressed genes (degs) were detected in the leaves of cd-stressed zcr compared with cr, while only 792 (521 up and 271 down) were detected in x.Strumarium♀ ×x.Sibiricum♂ (zlt) compared with lt.A large number of dges in zcr and zlt are involved in abscisic acid (aba) synthesis and signal transduction.The genes induced by aba in zcr, including cngc5/20, cpk1/28, cml, pti1-like tyrosine-protein kinase 3, respiratory burst oxidase homolog protein c, and wrky transcription factor 33 were found differentially expressed compared cr.Carotenoid cleavage dioxygenase 4, nced1/2, phytoene synthase 2, and cyp707a involved in aba synthesis and decomposition in zlt were found differentially expressed compared lt.We speculated that aba played an important role in cd transportation of hybrids and cd distribution in senescent and normal leaves.The results demonstrate that hybridization with an invasive plant improves the adaptability of the hybrid to cd stress and may enhance the extinction risk of native congener in pollution environment.

Journal: Frontiers in plant science (2021)
Publication types: Journal Article
Small molecule inhibitors and culture conditions enhance therapeutic cell and EV potency via activation of beta-catenin and suppression of THY1.

Primary cell therapy continues to face significant hurdles to therapeutic translation including the inherent variations that exist from donor to donor, batch to batch, and scale-up driven modifications to the manufacturing process.Cardiosphere-derived cells (cdcs) are stromal/progenitor cells with clinically demonstrated tissue reparative capabilities.Mechanistic investigations have identified canonical wnt/β-catenin signaling as a therapeutic potency marker, and thy1 (cd90) expression as inversely correlated with potency.Here we demonstrate that the cardiosphere formation process increases β-catenin levels and enriches for therapeutic mi r content in the extracellular vesicles of these cells, namely mi r-146a and mi r-22.We further find that loss of potency is correlated with impaired cardiosphere formation.Finally, our data show that small gsk3β inhibitors including chir, and bio and "pro-canonical wnt" culturing conditions can rescue β-catenin signaling and reduce cd90 expression.These findings identify strategies that could be used to maintain cdc potency and therapeutic consistency.

Journal: Nanomedicine : nanotechnology, biology, and medicine (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, U.S. Gov't, Non-P.H.S.
Asociación del signo de Moore con la presencia de absceso profundo de cuello de espacio retrofaríngeo.

Deep neck abscesses can cause life-threatening complications.They are diagnosed by physical examination, and contrasted tomography as the gold standard.There are no studies about the association of moore's sign with infections of the retropharyngeal space.Objective to determine the usefulness of moore's sign in the diagnosis of deep retropharyngeal abscess.Method observational, analytical, cross-sectional, study of patients with deep neck abscess, from may 1, 2019, to august 30, 2021, with report of moore's sign.Results 87 patients were included, 49 (56.3%) males (p = 0.45).Of those who developed complications, 77.8% had a negative moore's sign (p = 0.001).Of those admitted to the icu, 72% had a negative moore's sign (p = 0.001).The sensitivity of the absence of the sign with retropharyngeal involvement was 95.4%, and the specificity was 86.3%.By logistic regression, it was found that those with retropharyngeal involvement are 467 times more likely to present a negative sign (p < 0.05).Conclusions the presence of abscess in the retropharynx is associated with complications and a worse prognosis.The evaluation of moore's sign can be a useful tool to suspect compromise of this space.

Journal: Cirugia y cirujanos (2022)
Publication types: Journal Article;Observational Study
Evaluation of affective temperament profile and levels of depressive symptoms and anxiety in patients with restless legs syndrome.

Restless legs syndrome (rls) is a sleep-related sensorimotor disorder associated with mood and anxiety disorders.Although affective temperaments are considered subclinical manifestations of mood disorders (mds), to date, no previous research has explored the relationship between affective temperaments and rls.We aimed to evaluate affective temperaments, depressive symptoms, and anxiety among newly diagnosed, drug-naive patients with rls.Additionally, our study identified possible associations between clinical variables and affective temperaments, depressive symptoms, and anxiety profiles in this group.Methods the study included 74 patients with rls and 90 healthy volunteers.All participants performed the temperament evaluation of memphis, pisa, paris, and san diego autoquestionnaire, beck depression inventory, and hamilton anxiety inventory.Results temperament, depression, and anxiety scores in patients with rls were significantly higher than those in healthy controls (p ≤ 0.05).Linear regression analysis showed that anxious temperament scores were positively related to longer disease duration (β = 0.658, p = 0.000), whereas disease severity (as measured by the international rls study group rating scale) (β = 0.447, p = 0.006) and lower educational status (β = - 0.803, p = 0.008) correlated with the anxiety profile.Conclusions results suggested that higher scores on the affective temperament, depression, and anxiety scales indicate subclinical mds and psychiatric comorbidities in rls.Therefore, exploring the predictors of mood and anxiety disorders in patients with rls may improve treatment strategies and clinical outcomes.

Journal: Sleep & breathing = Schlaf & Atmung (2022)
Publication types: Journal Article
The Overfilled Face.

The desire for longevity, beauty, and health is as old as the history of human culture.Minimizing tissue damage and invasive surgeries has led to a variety of options in the 21stcentury medicine.In the past 20 years, hyaluronic acid filler injections have thus become a popular modality of treatment for facial rejuvenation due to low costs for patients with immediately visible results.Ideally, the treated face looks natural.We aim at stopping time, maybe tweaking the handles of our clocks a bit backward to counteract aging processes, but creating a natural look and maintaining the individual appearance.

Journal: Facial plastic surgery : FPS (2022)
Publication types: Journal Article
Compact magnetic field sensor based on plasmonic fiber-tip.

A plasmonic fiber-tip based on the metallic metasurface and the multimode fiber (mmf) alleviates the limitation of the inevitable large sensing size caused by fiber side wall functionalization.Localized surface plasmon resonance (lspr) based on metasurface on the fiber-tip provides a promising way to manipulate and interrogate the transmitted and reflection light in sub-wavelength range.Combining the advantages of plasmonic fiber-tip and magnetic fluid, a compact magnetic field fiber-optic sensor is proposed and verified by experiments.The developed fiber-optic magnetic field sensor has linear response and high magnetic strength sensitivity of 0.532 nm/m t over a range of 0-20 m t.In addition, the results also prove the feasibility of pseudo-vector magnetic field sensing.

Journal: Optics express (2021)
Publication types: Journal Article
Impact of donor nutritional balance on the growth and development of mesenchymal stem cells from caprine umbilical cord Wharton´s jelly.

Mesenchymal stem cells (mscs) from the umbilical cord (uc) have aroused considerable interest.However, little is known about the maternal effect on these cells.The aim of this study was to verify the impact of the nutritional status of donor goats on the growth and differentiation of mscs from the uc.At parturition, 19 goats were grouped based on their low or high body mass index (low bmi, lbmi, n = 9; and high bmi, hbmi, n = 10).Ucs were collected during delivery and wharton's jelly (wj) fragments cultured.Wj-mscs were differentiated into osteocytes, adipocytes, chondrocytes, and the population doubling time (pdt) was determined.Samples of wj-mscs were also used to verify the expression of the cd90, cd73, cd34, cd45, and cd105 genes.Media used for wj-msc primary cultures were analyzed using near-infrared spectroscopy.The lag phase was 7.5 ± 0.6 days and the entire culture took 26.7 ± 1.3 days, with a cell proliferation rate of 8.500 cells/day.The mean pdt from subculture was 30.0 ± 0.7 h.The cd105 gene was sub-expressed in lbmi, and the spectra of the spent media from the second to fourth day of wj-msc primary culture were segregated into negative scores by multivariate analysis.We conclude that, in goats, the nutritional balance of the donor did not affect the in vitro growth of mscs derived from the uc.However, the molecular profile observed in the low bmi group suggests that the use of mscs for therapeutic purposes should be considered more carefully.

Journal: Veterinary research communications (2022)
Publication types: Journal Article
Aldehyde-Functionalized Magnetic Particles to Capture Off-Target Chemotherapeutic Agents.

Drug capture is a promising technique to prevent off-target chemotherapeutic agents from reaching systemic circulation and causing severe side effects.The current work examines the viability of using immobilized aldehydes for drug-capture applicationsvia schiff base formation between doxorubicin (dox) and aldehydes.Commercially available pyridoxal-5'-phosphate (vb6) was immobilized on iron oxide nanoparticles (ionps) to capture dox from human serum.Leaching of vb6 persisted as a primary issue and thus various aldehydes with anchoring groups such as catechol, silatrane, and phosphonate esters have been studied.The phosphonate group-based anchor was the most stable and used for further capture studies.To improve the hydrophilic nature of the aldehydes, sulfonate-containing aldehydes and polyethylene glycols (pegs) were investigated.Finally, the optimized functionalized iron oxide particles, pegylated-ionp, were used to demonstrate doxorubicin capture from human serum at biologically relevant temperature (37 °c), time (30 min), and concentrations (μm).The current study sets the stage for the development of potential compact dimension capture device based on surface-anchorable polymers with aldehyde groups.

Journal: ACS omega (2020)
Publication types: Journal Article