syedzayyan/paper_mill_benchmark huggingface dataset:
Gene mutations associated with fertilization failure afterin vitrofertilization/intracytoplasmic sperm injection.

Fertilization failure during assisted reproductive technologies (art) is often unpredictable, as this failure is encountered only after in vitro fertilization (ivf) and intracytoplasmic sperm injection (icsi) have been performed.The etiology of fertilization failure remains elusive.More and more mutations of genes are found to be involved in human fertilization failure in infertile patients as high throughput sequencing techniques are becoming widely applied.In this review, the mutations of nine important genes expressed in sperm or oocytes,plcz1, actl7a, actl9, dnah17, wee2, tubb8, nlrp5, zp2, and tle6, were summarized and discussed.These abnormalities mainly have shown mendelian patterns of inheritance, including dominant and recessive inheritance, although de novo mutations were present in some cases.The review revealed the crucial roles of each reported gene in the fertilization process and summarized all known mutations and their corresponding phenotypes.The review suggested the mutations might become promising targets for precision treatments in reproductive medicine.Moreover, our work will provide some helpful clues for genetic counseling, risk prediction, and optimizing clinical treatments for human infertility by supplying the useful and timely information on the genetic causes leading to fertilization failure.

Journal: Frontiers in endocrinology (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't
Status and prospects of atmospheric microplastics: A review of methods, occurrence, composition, source and health risks.

The global pollution of microplastics (mps) has attracted widespread attention, and the atmosphere was an indispensable media for the global transmission of mps.With the growing awareness of mps, atmospheric microplastics (amps) have been proposed as a new topic in recent years.Compared with the extensive studies on mps in marine and terrestrial environments, the studies of amps remain limited.In this study, sampling and analysis methods, occurrence, source analysis and health risk of amps were summarized and discussed.According to the different sampling methods, amps can be divided into suspension microplastics (samps) and deposition microplastics (damps).Previous studies have shown that samps and damps differ in composition and abundance, with samps generally having a higher fraction of fragments.The mechanism of the migration of amps between different media was not clear yet.We further collated global data on the composition characteristics of mps in soil and fresh water, which showed that the fragment mps in soil and fresh water was higher than that in the atmosphere.Polymers in soil and fresh water were mainly pp and pe, while amps in the atmosphere were mainly pet.The shape composition of the mps in both atmospheric and freshwater systems suggests that there may be the same dominant factor.The transport of amps and source apportionment were the important issues of current research, but both of them were at the initial stage.Therefore, amps needs to be further studied, especially for the source and fate, which would be conducive to understand the global distribution of amps.Furthermore, a standardized manual on sampling and processing of amps was also necessary to facilitate the comparative analysis of data between different studies and the construction of global models.

Journal: Environmental pollution (Barking, Essex : 1987) (2022)
Publication types: Journal Article;Review
Research Progress in the Multilayer Hydrogels.

Hydrogels have been widely used in many fields including biomedicine and water treatment.Significant achievements have been made in these fields due to the extraordinary properties of hydrogels, such as facile processability and tissue similarity.However, based on the in-depth study of the microstructures of hydrogels, as a result of the enhancement of biomedical requirements in drug delivery, cell encapsulation, cartilage regeneration, and other aspects, it is challenge for conventional homogeneous hydrogels to simultaneously meet different needs.Fortunately, heterogeneous multilayer hydrogels have emerged and become an important branch of hydrogels research.In this review, their main preparation processes and mechanisms as well as their composites from different resources and methods, are introduced.Moreover, the more recent achievements and potential applications are also highlighted, and their future development prospects are clarified and briefly discussed.

Journal: Gels (Basel, Switzerland) (2021)
Publication types: Journal Article;Review
Phleboliths of the Head and Neck Region - A Case Report.

Rationale phleboliths are idiopathic calcifications resulting from mineralised structures inside veins, venules or blood vessels.Patient concerns a 48-year-old woman presented with multiple hard bodies on palpation.Diagnosis imaging studies revealed multiple, round, well-defined radiopaque lesions, extending from the coronoid process region down to the base of the mandible.The diagnosis was vascular malformation with multiple phleboliths.Treatment and outcome no treatment was proposed and the patient is under follow-up.Take-away lessons asymptomatic phleboliths of the head and neck region in an adult woman have been under surveillance.

Journal: Annals of maxillofacial surgery (2022)
Publication types: Case Reports;Journal Article
Inference of age-associated transcription factor regulatory activity changes in single cells.

Transcription factors (tfs) control cell identity and function.How their activity is altered during healthy aging is critical for an improved understanding of aging and disease risk, yet relatively little is known about such changes at cell-type resolution.Here we present and validate a tf activity estimation method for single cells from the hematopoietic system that is based on tf regulons, and apply it to a mouse single-cell rna-sequencing atlas, to infer age-associated differentiation activity changes in the immune cells of different organs.This revealed an age-associated signature of macrophage dedifferentiation, which is shared across tissue types, and aggravated in tumor-associated macrophages.By extending the analysis to all major cell types, we reveal cell-type and tissue-type-independent age-associated alterations to regulatory factors controlling antigen processing, inflammation, collagen processing and circadian rhythm, that are implicated in age-related diseases.Finally, our study highlights the limitations of using tf expression to infer age-associated changes, underscoring the need to use regulatory activity inference methods.

Journal: Nature aging (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Accelerated Laboratory Weathering of Polypropylene/Poly (Lactic Acid) Blends.

To solve the pollution problems that result from polypropylene (pp), suitable biopolymers such as poly (lactic acid) (pla) were selected to blend with pp.Since pp/pla blends are often exposed to the natural environment, it is necessary to study the photodegradation behavior of pp/pla blends.In this paper, pp/pla blends with different compositions were prepared by extrusion and subjected to the accelerated laboratory weathering equipment.The effects of compatibilizers on the degradation behavior of pp/pla blends were also studied.The weatherability of pp/pla blends was studied through weight loss, optical microscope, fourier-transform infrared spectroscopy (ftir), thermogravimetric analysis (tga), and differential scanning calorimetry (dsc).The results revealed that pp is easy to degrade than pla during accelerated laboratory weathering.Pp/pla blends are susceptible to the accelerated laboratory weathering process, and pp-rich and pla-rich blends reduce the weathering resistance.Moreover, the results indicate that the initial degradation temperature, melting temperature, and crystallization temperature decrease after weathering related to the decreased thermal stability of pp/pla blends.For instance, the initial degradation temperature of pp/pla8.2 reduces from 332.2 °c to 320.2 °c.Moreover, the compatibilized sample is generally more resistant to weathering conditions than the uncompatibilized one due to the higher compatibility of pp and pla.

Journal: Polymers (2022)
Publication types: Journal Article
Predictive and prognostic effect of ABO blood group on immune checkpoint inhibitors.

The relationship of the abo blood group system with the immune response is known, but its relationship with immune checkpoint inhibitors (icis) has not been clearly investigated until now.Objective in this study, the relationship between different blood groups and nivolumab treatment response in patients with advanced malignant melanoma was investigated.Methods the data of patients who used nivolumab for advanced malignant melanoma between april 2018 and april 2021 were retrospectively reviewed.Results a total of 73 patients were included in the study.In the progression-free survival (pfs) analysis according to blood groups, it was 3.9 months, 16.1 months, 20.0 months and 3.0 months for a, b, ab and o, respectively (p= 0.1).Overall survival (os) analysis according to blood groups was 5.1 months, 25.0 months, 20.0 months and 9.3 months for a, b, ab and o, respectively (p= 0.1).The b antigen group (b or ab) had significantly longer pfs and os than the non-b antigen group (a or o) (16.1 vs.3.5 months for pfs, respectively, p= 0.03; 20.0 vs.7.4 months for os, respectively, p= 0.02).Conclusions the presence of b antigen provides a significant advantage in terms of survival in patients using icis for advanced melanoma.

Journal: Cancer biomarkers : section A of Disease markers (2022)
Publication types: Journal Article
Syndesmosis Changes before and after Syndesmotic Screw Removal: A Retrospective Radiographic Study.

And objectives in patients with ankle fractures complicated by syndesmotic injuries, no consensus has been reached on the best method of syndesmosis fixation using syndesmotic screws.One previous study revealed no difference in the tibiofibular overlap between two groups with or without syndesmotic screw removal.Other studies have indicated that distal tibiofibular diastasis exists after the removal of syndesmotic screws.In this study, we aimed to confirm the effect of syndesmotic screw removal on diastasis occurrence.We further analyzed the risk factors that may contribute to the widening of the tibiofibular syndesmosis.Materials and methods this retrospective study involved a review of the records of 63 patients with ankle fractures accompanied by syndesmosis injuries that required syndesmotic screw fixation.Anteroposterior radiographs were analyzed for each patient at various time points, from syndesmotic screw fixation to outpatient department follow-ups after screw removal.The changes in tibia-fibula overlap (ol), tibia-fibula clear space (cs), and medial clear space (mcs) were analyzed.Further analysis was performed to reveal potential factors that may have contributed to radiographic differences.Results compared with the postoperation radiographs following syndesmotic screw fixation, ol decreased (2.0 mm) and cs increased (0.8 mm) in the anteroposterior radiographs from outpatient department follow-ups.No significant changes were noted in ol or cs after syndesmotic screw removal.However, ol decreased (1.8 mm) and cs increased (0.5 mm) before syndesmotic screw removal.No significant change in mcs occurred during the whole observation period.Linear regression analysis did not reveal any significant correlations between potentially related factors and radiographic changes.Conclusions marked diastasis had occurred at final follow-up.Notably, the diastasis occurred before rather than after screw removal.This implies that screw removal does not significantly influence the radiographic outcomes of rotational ankle fractures.

Journal: Medicina (Kaunas, Lithuania) (2022)
Publication types: Journal Article;Review
Development of Biocompatible Ene-Ligation Enabled by Prenyl-Based β-Caryophyllene with Triazoline/Selectfluor under Physiological Conditions.

Here, we first report a rapid and highly selective biocompatible ligation that proceeds via a strain-promoted prenyl-involved [2, 3]-ene rearrangement process.We demonstrate the usefulness of naturally occurring strain-promoted β-caryophyllene with triazoline (ptad)/selectfluor in the study of tagging molecule-of-interest.Experiments in peptide (histone h3 (1-21) and myhc (614-629)) and protein (bsa, βlg, and hsp40) models exemplified the utility of the ene-ligation for in vivo imaging and tracking.

Journal: The Journal of organic chemistry (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Sourcing Elephant Ivory from a Sixteenth-Century Portuguese Shipwreck.

The oldest known shipwreck in southern africa was found in namibia in 2008.1-4forty tons of cargo, including gold and silver coins, helped identify the ship as the bom jesus, a portuguese nau (trading vessel) lost in 1533 while headed to india.4-6the cargo included >100 elephant tusks,7which we examined using paleogenomic and stable isotope analyses.Nuclear dna identified the ivory source as african forest (loxodonta cyclotis) rather than savanna (loxodonta africana) elephants.Mitochondrial sequences traced them to west and not central africa and from ≥17 herds with distinct haplotypes.Four of the haplotypes are known from modern populations; others were potentially lost to subsequent hunting of elephants for ivory.Stable isotope analyses (δ13c and δ15n) indicated that the elephants were not from deep rainforests but from savanna and mixed habitats.Such habitats surround the guinean forest block of west africa8and accord with the locations of major historic portuguese trading ports.9,10west african forest elephants currently range into savanna habitats;11-13our findings suggest that this was not consequent to regional decimation of savanna elephants for their ivory in the 19thand 20thcenturies.During the time of the bom jesus, ivory was a central driver in the formation of maritime trading systems connecting europe, africa, and asia.Our integration of paleogenomic, archeological, and historical methods to analyze the bom jesus ivory provides a framework for examining vast collections of archaeological ivories around the world, in shipwrecks and other contexts.

Journal: Current biology : CB (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Is the use of platelet-rich fibrin effective in the healing, control of pain, and postoperative bleeding in the palatal area after free gingival graft harvesting? A systematic review of randomized clinical studies.

A systematic review (sr) was conducted to answer the following focused question based on pico strategy: in patients who were submitted to harvesting palatal free gingival graft, could platelet-rich fibrin (prf) application in comparison with another method improve the healing, pain, and control of postoperative bleeding in the palatal area in randomized clinical trials?Methods a sr was conducted according to the prisma guidelines.The medline (pub med), scopus, embase, and web of science databases were searched, and hand searches were made, covering the period up to august 2020, for randomized clinical trials (rcts) reporting the effect of prf membrane in postoperative palatal healing management compared with any other methods.The risk of bias (ro b) of the studies included was assessed by using the ro b 2 tool.Results the electronic search strategy identified 150 articles.After title screening and abstract reading, 141 studies were excluded, and 9 full-text publications were comprehensively evaluated.Finally, 8 articles were included in the systematic review.Six studies showed that the prf membrane was effective in improving wound healing during the first 2 weeks.As regards patient-centered outcomes, five studies showed that prf promoted less postoperative pain.Finally, five studies that evaluated bleeding showed that the prf membrane improved control of postoperative bleeding.Ro b was classified as low in 4 studies, 3 with some concerns, and only one study did not describe the outcome data, and as this was missing, it was not possible to verify the protocol of data analysis for this study; therefore, it was classified as having high ro b.Conclusion within the limitations of this study, the collective evidence emerging from this sr may support the use of prf membrane in the palatal area after free gingival graft harvesting.The results of this review must be interpreted with caution, due to the low number of rcts included and high degree of heterogeneity among the prf protocols.Further well-designed rcts with accurate protocol and standard prf parameters are required in order to gain clear understanding of the influence of prf on wound healing and patient-centered outcomes.Clinical relevance the use of prf membrane for the protection of the palatal donor site following free gingival graft harvesting procedures improves wound healing and patients' quality of life.

Journal: Clinical oral investigations (2021)
Publication types: Journal Article;Review;Systematic Review
Density functionals with spin-density accuracy for open shells.

Electrons in zero external magnetic field can be studied with the kohn-sham (ks) scheme of either density functional theory (dft) or spin-dft (sdft).The latter is normally used for open-shell systems because its approximations appear to model better the exchange and correlation (xc) functional, but also because, so far the application of dft implied a closed-shell-like approximation.In the first part of this communication, we show that correcting this error for open shells allows the approximate dft xc functionals to become as accurate as those in sdft.In the second part, we consider the behavior of sdft for zero magnetic field.We show that the ks equations of sdft emerge as the generalized ks equations of dft in this limit, thus establishing a so far unknown link between the two theories.

Journal: The Journal of chemical physics (2022)
Publication types: Journal Article
Design of automatic urine collection system for medical system applications.

The results of urine tests are often affected by improper midstream urine collection time, urine spilling, and urine pollution, all of which can lead to an increase in the test error.Objective to solve this problem, aiming at improving the toilet environment at the hospitals and public physical examination centers, this paper designs an automatic urine collection system.It can automatically adjust the position of the urine cup with an infrared remote controller, or manually, adjust the position of the urine cup in special situations according to the needs of the user.It also has an alarm function.Methods the overall size and shape are designed based on the squatting pan, suitable for disposable plastic urine cups of different shapes and sizes.It can realize the automatic collection of midstream urine, manual collection in exceptional cases, emergency stops, and rescue calls.Results through the trial survey, there was a significant difference between the statistical results of using the device and not using the device (t= 13.937, p= 0.000).96% of the subjects thought that the design of the system was reasonable, 22% thought that it was inconvenient to use, and 91.7% of the medical staff thought that the system met the sampling requirements.Conclusions therefore, the trial evaluation is satisfactory, and the proposed collection system is suitable for use in hospitals at all levels and public health examination centers with a large amount of inspection.

Journal: Technology and health care : official journal of the European Society for Engineering and Medicine (2022)
Publication types: Journal Article
Increasing the safety of minimally invasive hallux surgery-An anatomical study introducing the clock method.

The purpose of this study is to describe a simple and reproducible method to localize the neurological structures at risk and to describe a safe zone for hallux minimally invasive surgery (mis) procedures.Methods ten fresh-frozen cadaveric feet were dissected to identify the dorsomedial digital nerve (dmdn) and the dorsolateral digital nerve (dldn) of the first toe.Axial sections were performed at the sites of metatarsal osteotomies.We documented the position of the nerves with respect to the extensor hallucis longus (ehl) tendon using a clock method superimposed on the axial section results: the dmdn was found at an average of 26.2° medial to the medial border of the ehl tendon.(sd 11.26, range 14.5-45.5), whereas the average distance of the dldn was 32.3° lateral to the medial border of the ehl tendon.(sd 6.29, range 13.5-40).Conclusions using the clock method the dmdn and dldn were found consistently between 10 o'clock and 2 o'clock in either right and left feet.The clock method may facilitate avoiding the area where these nerves are located serving as a valuable tool in minimally invasive foot surgery.

Journal: Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons (2018)
Publication types: Journal Article
Radiatively Generating the Higgs Potential and Electroweak Scale via the Seesaw Mechanism.

The minimal seesaw scenario can radiatively generate the higgs potential to induce electroweak symmetry breaking while supplying an origin of the higgs vacuum expectation value from an underlying majorana scale.If the higgs potential and (derived) electroweak scale have this origin, the heavy su(3)×su(2)×u(1)_{y} singlet states are expected to reside at m_{n}∼10-500 pe v for couplings |ω|∼10^{-4.5}-10^{-6} between the majorana sector and the standard model.In this framework, the usual challenge of the electroweak scale hierarchy problem with a classically assumed potential is absent as the electroweak scale is not a fundamental scale.The new challenge is the need to generate or accommodate pe v majorana mass scales while simultaneously suppressing tree-level contributions to the potential in ultraviolet models.

Journal: Physical review letters (2017)
Publication types: Journal Article