syedzayyan/paper_mill_benchmark huggingface dataset:
Exploring the Experiences of Family Caregivers of Children With Special Health Care Needs to Inform the Design of Digital Health Systems: Formative Qualitative Study.

Family caregivers of children with special health care needs (cshcn) are responsible for managing and communicating information regarding their child's health in their homes.Although family caregivers currently capture information through nondigital methods, digital health care applications are a promising solution for supporting the standardization of information management in complex home care across their child's health care team.However, family caregivers continue to use paper-based methods where the adoption of digital health care tools is low.With the rise in home care for children with complex health care needs, it is important to understand the caregiving work domain to inform the design of technologies that support child safety in the home.Objective the aim of this study is to explore how family caregivers navigate information management and communication in complex home care for cshcn.Methods this research is part of a broader study to explore caregivers' perspectives on integrating and designing digital health care tools for complex home care.The broader study included interviews and surveys about designing a voice user interface to support home care.This formative study explored semistructured interview data with family caregivers of cshcn about their home care situations.Inductive thematic analysis was used to analyze the information management and communication processes.Results we collected data from 7 family caregivers in north america and identified 5 themes.First, family caregivers were continuously learning to provide care.They were also updating the caregiver team on their child's status and teaching caregivers about their care situation.As caregiving teams grew, they found themselves working on communicating with their children's educators.Beyond the scope of managing their child's health information, family caregivers also navigated bureaucratic processes for their child's home care.Conclusions family caregivers' experiences of caring for cshcn differ contextually and evolve as their child's condition changes and they grow toward adulthood.Family caregivers recorded information using paper-based tools, which did not sufficiently support information management.They also experienced significant pressure in summarizing information and coordinating 2-way communication about the details of their child's health with caregivers.The design of digital health care systems and tools for complex home care may improve care coordination if they provide an intuitive method for information interaction and significant utility by delivering situation-specific insights and adapting to unique and dynamic home care environments.Although these findings provide a foundational understanding, there is an opportunity for further research to generalize the findings.

Journal: JMIR formative research (2022)
Publication types: Journal Article
A Reasonable Evaluation ofChuanxiong RhizomaProcessing with Wine through Comparative Pharmacokinetic Study of Bioactive Components: Dominant Effect on Middle Cerebral Artery Occlusion Model Rats.

According to the ancient documents and chinese herbal medicine processing experience,chuanxiong rhizomawas usually processed with yellow rice wine to improve efficacy.However, the relevant mechanisms are still unclear so far.In this study, a validated ultrahigh-performance liquid chromatography tandem mass spectrometry method was used to compare the pharmacokinetics of four representative components in middle cerebral artery occlusion rats after oral administration of raw and wine-processed chuanxiong rhizoma.The neurobehavioral scores and 2,3,5-triphenyltetrazolium chloride staining were employed to evaluate the model.Biological samples were prepared by protein precipitation with methanol.All analytes were separated on an acquity beh c18column through gradient elution using acetonitrile and 0.01% of formic acid as mobile phase, and the flow rate was 0.3 m l/min.The results showed that the maximum plasma concentrations, the area values under the concentration-time curves of senkyunolide a, and ferulic acid in wine-processed chuanxiong rhizomawere all higher than in raw chuanxiong rhizoma, which were completely opposite to our previous studies in normal rats.Compared with normal rats, the theory that wine processing could enhance the efficacy of chuanxiong rhizomamay be better reflected in model rats.

Journal: Journal of analytical methods in chemistry (2022)
Publication types: Journal Article
Myocardial Injury Pattern at MRI in COVID-19 Vaccine-Associated Myocarditis.

There are limited data on the pattern and severity of myocardial injury in patients with covid-19 vaccination-associated myocarditis.Purpose to describe myocardial injury following covid-19 vaccination and to compare these findings to other causes of myocarditis.Materials and methods in this retrospective cohort study, consecutive adult patients with myocarditis with at least one t1-based and at least one t2-based abnormality at cardiac mri performed at a tertiary referral hospital from december 2019 to november 2021 were included.Patients were classified into one of three groups: myocarditis following covid-19 vaccination, myocarditis following covid-19 illness, and other myocarditis not associated with covid-19 vaccination or illness.Results of the 92 included patients, 21 (23%) had myocarditis following covid-19 vaccination (mean age, 31 years ± 14 [sd]; 17 men; messenger rna-1273 in 12 [57%] and bnt162b2 in nine [43%]).Ten of 92 (11%) patients had myocarditis following covid-19 illness (mean age, 51 years ± 14; three men) and 61 of 92 (66%) patients had other myocarditis (mean age, 44 years ± 18; 36 men).Mri findings in the 21 patients with vaccine-associated myocarditis included late gadolinium enhancement (lge) in 17 patients (81%) and left ventricular dysfunction in six (29%).Compared with other causes of myocarditis, patients with vaccine-associated myocarditis had a higher left ventricular ejection fraction and less extensive lge, even after controlling for age, sex, and time from symptom onset to mri.The most frequent location of lge in all groups was subepicardial at the basal inferolateral wall, although septal involvement was less common in vaccine-associated myocarditis.At short-term follow-up (median, 22 days [iqr, 7-48 days]), all patients with vaccine-associated myocarditis were asymptomatic with no adverse events.Conclusion cardiac mri demonstrated a similar pattern of myocardial injury in vaccine-associated myocarditis compared with other causes, although abnormalities were less severe, with less frequent septal involvement and no adverse events over the short-term follow-up.© rsna, 2022online supplemental material is available for this article.see also the editorial by raman and neubauer in this issue.

Journal: Radiology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
TNF-α/anti-TNF-αdrugs and its effect on pregnancy outcomes.

Pregnancy is a complex biological process.The establishment and maintenance of foetal-maternal interface are pivotal events.Decidual immune cells and inflammatory cytokines play indispensable roles in the foetal-maternal interface.The disfunction of decidual immune cells leads to adverse pregnancy outcome.Tumour necrosis factor (tnf)-α, a common inflammatory cytokine, has critical roles in different stages of normal pregnancy process.However, the relationship between the disorder of tnf-αand adverse pregnancy outcomes, including preeclampsia (pe), intrauterine growth restriction (iugr), spontaneous abortion (sa), preterm birth and so on, is still indefinite.In this review, we thoroughly reviewed the effect of tnf-αdisorder on pathological conditions.Moreover, we summarized the reports about the adverse pregnancy outcomes (pe, iugr, sa and preterm birth) of using anti-tnf-αdrugs (infliximab, etanercept and adalimumab, certolizumab and golimumab) currently in the clinical studies.Overall, iugr, sa and preterm birth are the most common adverse pregnancy outcomes of anti-tnf-αdrugs.Our review may provide insight for the immunological treatment of pregnancy-related complication, and help practitioners make informed decisions based on the current evidences.

Journal: Expert reviews in molecular medicine (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't
Therapy for Crohn's Disease: a Review of Recent Developments.

Of review to review recent advances in the treatment of crohn's disease.Recent findings several key advances are highlighted, including the increasing role of treatment algorithms and where new therapies can be used most effectively, the appropriate use of therapeutic drug monitoring, optimal management of post-surgical patients, and the role of multi-disciplinary clinics.The last several years have seen a number of exciting developments in the field of crohn's therapy.This review covers research advances including updated treatment algorithms focusing on identifying patient risk as well as the role of drug monitoring in managing the disease.We also review the optimal management of post-surgical patients as well as new biologics and biosimilars.Finally, we describe innovations in care delivery including multi-disciplinary clinics and emerging evidence from developing therapeutics.

Journal: Current gastroenterology reports (2018)
Publication types: Journal Article;Review
Plasmonic Au@Ag@mSiO2Nanorattles for In Situ Imaging of Bacterial Metabolism by Surface-Enhanced Raman Scattering Spectroscopy.

It is well known that microbial populations and their interactions are largely influenced by their secreted metabolites.Noninvasive and spatiotemporal monitoring and imaging of such extracellular metabolic byproducts can be correlated with biological phenotypes of interest and provide new insights into the structure and development of microbial communities.Herein, we report a surface-enhanced raman scattering (sers) hybrid substrate consisting of plasmonic au@ag@m si o2nanorattles for optophysiological monitoring of extracellular metabolism in microbial populations.A key element of the sers substrate is the mesoporous silica shell encapsulating single plasmonic nanoparticles, which furnishes colloidal stability and molecular sieving capabilities to the engineered nanostructures, thereby realizing robust, sensitive, and reliable measurements.The reported sers-based approach may be used as a powerful tool for deciphering the role of extracellular metabolites and physicochemical factors in microbial community dynamics and interactions.

Journal: ACS applied materials & interfaces (2021)
Publication types: Journal Article
Preferences for work arrangements: A discrete choice experiment.

This study investigates individual preferences for work arrangements in a discrete choice experiment.Based on sociological and economic literature, we identified six essential job attributes-earnings, job security, training opportunities, scheduling flexibility, prestige of the company, and gender composition of the work team-and mapped these into hypothetical job offers.Out of three job offers, with different specifications in the respective job attributes, respondents had to choose the offer they considered as most attractive.In 2017, we implemented our choice experiment in two large-scale surveys conducted in two countries: germany (n = 2,659) and the netherlands (n = 2,678).Our analyses revealed that respondents considered all six job attributes in their decision process but had different priorities for each.Moreover, we found gendered preferences.Women preferred scheduling flexibility and a company with a good reputation, whereas men preferred jobs with high earnings and a permanent contract.Despite different national labor market regulations, different target populations, and different sampling strategies for the two surveys, job preferences for german and dutch respondents were largely parallel.

Journal: PloS one (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Differential effects of commensal bacteria on progenitor cell adhesion, division symmetry and tumorigenesis in theDrosophilaintestine.

Microbial factors influence homeostatic and oncogenic growth in the intestinal epithelium.However, we know little about immediate effects of commensal bacteria on stem cell division programs.In this study, we examined the effects of commensal lactobacillusspecies on homeostatic and tumorigenic stem cell proliferation in the female drosophilaintestine.We identified lactobacillus brevisas a potent stimulator of stem cell divisions.In a wild-type midgut,l.brevisactivates growth regulatory pathways that drive stem cell divisions.In a notch-deficient background,l.brevis-mediated proliferation causes rapid expansion of mutant progenitors, leading to accumulation of large, multi-layered tumors throughout the midgut.Mechanistically, we showed that l.brevisdisrupts expression and subcellular distribution of progenitor cell integrins, supporting symmetric divisions that expand intestinal stem cell populations.Collectively, our data emphasize the impact of commensal microbes on division and maintenance of the intestinal progenitor compartment.

Journal: Development (Cambridge, England) (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Asymptomatic bacteriuria in candidates for active treatment of renal stones: results from an international multicentric study on more than 2600 patients.

The occurrence of asymptomatic bacteriuria concomitant to urolithiasis is an issue for patients undergoing renal stone treatment.Disposing of a preoperative urine culture is essential to reduce the risk of septic events.The endpoint of the study is to report which characteristics of candidates for renal stone treatment are frequently associated with positive urine culture.2605 patients were retrospectively enrolled from 14 centers; inclusion criteria were age > 18 and presence of a single renal stone 1-2 cm in size.The variables collected included age, gender, previous renal surgery, comorbidities, skin-to-stone distance, stone size, location, density, presence of hydronephrosis.After a descriptive analysis, the association between continuous and categorical variables and the presence of positive urine culture was assessed using a logistic regression model.Overall, 240/2605 patients (9%) had preoperative bacteriuria.Positive urine culture was more frequent in females, patients with previous renal interventions, chronic kidney disease, congenital anomalies, larger stones, increased density.Multivariate analysis demonstrated that previous renal interventions (or 2.6; 95% ci 1.9-3.4; p < 0.001), renal-related comorbidities (or 1.31; 95% ci 1.19-1.4; p < 0.001), higher stone size (or 1.06; 95% ci 1.02-1.1; p = 0.01) and density (or 1.00; 95% ci 1.0-1.00; p = 0.02) were associated with bacteriuria; male gender and lower caliceal location were inversely related to it.Beyond expected risk factors, such as female gender, other parameters are seemingly favoring the presence of positive urine culture.The awareness of variables associated with bacteriuria allows to assess which individuals are at increased risk of presenting bacteriuria and reduce the rate of septic complications.

Journal: Urolithiasis (2022)
Publication types: Multicenter Study;Journal Article
A mathematical model of blood flow in a stenosed artery with post-stenotic dilatation and a forced field.

Arterial stenosis is a common cardiovascular disease that restricts blood flow.A stenotic blood vessel creates tangent stress pressure, which lessens the arterial side and causes an aneurysm.The primary purpose of this study is to investigate blood flowing via an inclination pipe with stricture and expansion after stricture (widening) underneath the influence of a constant incompressible casson liquid flowing with the magnetism field.The relations for surface shearing stress, pressure drop, flow resistance, and velocity are calculated analytically by applying a mild stenosis approximation.The effect of different physical characteristics on liquid impedance to flowing, velocity, and surface shearing stress are studied.With a non-newtonian aspect of the casson liquid, the surface shearing stress declines, and an impedance upturn.Side resistivity and shear-stress increase with the elevations of stricture, whilst together decreasing with a dilatation height.

Journal: PloS one (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The effects of apigenin administration on the inhibition of inflammatory responses and oxidative stress in the lung injury models: a systematic review and meta-analysis of preclinical evidence.

/objective apigenin is a member of the flavonoid family that can regulate various biological processes, which is characterized as a treatment of different inflammatory disorders and pathological problems associated with oxidative stress (os).Recent research has focused on apigenin immunomodulatory properties as a potential treatment for different types of lung injuries.This meta-analysis was designed to determine the impact of apigenin treatment on inflammatory markers and os parameters in animal models of lung injuries.Methods the comprehensive literature search was conducted using electronic databases such as google scholar, pub med, web of science, scopus, and embase up to august 2021.To assess apigenin's effect on inflammatory mediators and os biomarkers in lung injury animal models, we used the i2statistic to determine the heterogeneity.We then pooled data as standardized mean difference (smd) with a 95% confidence interval (ci).Results our meta-analysis of the pooled data for inflammatory biomarkers demonstrated that the apigenin administration significantly decreased the nf-κb expression (smd - 1.60, 95% ci [- 2.93 to - 0.26]; i2= 89.0%, p < 0.001), il-1β (smd - 4.30, 95% ci [- 6.24 to - 2.37]; i2= 67.3%, p = 0.047), il-6 (smd - 4.10, 95% ci [- 5.04 to - 3.16]; i2= 72.6%, p < 0.001), tnf-α (smd - 3.74, 95% ci [- 4.67 to - 2.82]; i2= 84.1%, p < 0.001), and tnf-α gene expression (smd - 3.44, 95% ci [- 4.44 to - 2.43]; i2= 0.0%, p = 0.622).This study also indicated the efficacy of apigenin in increasing the level of cat (smd 4.56, 95% ci [3.57 to 5.55]; i2= 15.3%, p = 3.15), gsh (smd 5.12, 95% ci [3.53 to 6.70]; i2= 77.6%, p < 0.001), and sod (smd 3.45, 95% ci [2.50 to 4.40]; i2= 79.2%, p < 0.001), and decreasing the level of mda (smd - 3.87, 95% ci [- 5.25 to - 2.49]; i2= 80.3%, p < 0.001) and mpo (smd - 4.02, 95% ci [- 5.64 to - 2.40]; i2= 88.9%, p < 0.001), tgf- β (smd - 3.81, 95% ci [- 4.91 to - 2.70]; i2= 73.4%, p = 0.001) and w/d level (smd - 3.22, 95% ci [- 4.47 to - 1.97]; i2= 82.1%, p < 0.001) than control groups.Conclusion overall, our findings showed the immunomodulatory potential of apigenin as an alternative treatment for the suppression of inflammatory responses and os in different types of lung injury diseases.Nevertheless, due to the paucity of clinical studies, reliable preclinical models, and clinical settings, evaluating the influence of apigenin on lung injury is required in the future.Before conducting large-scale clinical trials, detailed human pharmacokinetic studies are also needed to establish dosage ranges and determine the initial safety and tolerability of apigenin.

Journal: Inflammopharmacology (2022)
Publication types: Journal Article;Meta-Analysis;Review;Systematic Review
Telomeres and aging.

Telomeres (the ttaggg repetitive dna at the ends of linear chromosomes) are part of the 3d spatial organization of the nuclear genome.Long-range 3d chromatin interactions also establish specific patterns of regulated gene expression.An emerging area of interest is the role of telomere 3d looping with interstitial telomeric sequences (its) through interactions with telomere shelterin proteins.Telomeres form interstitial telomere loops (itl) that interact with its and modify gene expression at distal genomic regions.Human laminopathies and telomeropathies often correlate with short telomeres.Since telomeres progressively shorten with increased turnover and chronological age in dividing somatic cells, itls may also change and have functional roles in normal and pathophysiological processes.Overall, telomeres help stabilize the nuclear genome with high fidelity throughout early adult life but diminish in post-reproductive age-associated pathology.

Journal: Current opinion in cell biology (2018)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Review
Global simulation of fine resolution land use/cover change and estimation of aboveground biomass carbon under the shared socioeconomic pathways.

Land use change driven by human activities plays a critical role in the terrestrial carbon budget through habitat loss and vegetation change.Despite the projections of the global population and economic growth under the framework of the shared socioeconomic pathways (ssps), little is known of land use/cover change (lucc) at a fine spatial resolution and how carbon pools respond to lucc under different ssps.This study projected the future global lucc with 1 km spatial resolution and a 10-year time step from 2010 to 2100 and then explored its direct impacts on aboveground biomass carbon (agb) under ssps.Scenario ssp3 yields the highest global cropland expansion, among which approximately 48% and 46% is expected to be located in the current forest land and grassland, respectively.Scenario ssp1 has the largest forest expansion and is mainly converted from grassland (54%) and cropland (30%).Due to the spatial change in land use/cover, global agb loss is expected to reach approximately 3.422 pg c in 2100 under scenario ssp3 and increases by approximately 0.587 pg c under scenario ssp1.Africa is expected to lose 30% of agb under the scenario ssp3.Aboveground biomass in asia will fix 0.774 pg c to reverse the agb loss in 2100 under scenario ssp1.The global carbon loss estimated by the land use products with 10 km and 25 km resolution are less than that with 1 km by 1.5% (ranging from -11.2% in africa to +34.0% in oceania) and 2.9% (ranging from -11.8% in africa to +24.0% in oceania), respectively.These findings suggest that sufficient spatial details in the existing ssp scenario projections could reduce the uncertainties of agb assessment, and reasonable land use development and management is a key measure to mitigate the negative impacts of lucc on the biomass carbon pool.

Journal: Journal of environmental management (2022)
Publication types: Journal Article
A Convenient Assay to Detect Protein Oxidation Caused by Redox-Active Quinones.

Redox-active quinones generate reactive oxygen species (ros) through their redox cycling with electron donors.Hydrogen peroxide (h2o2) causes s-oxidation of proteins and is associated with activation of the redox signaling pathway and/or toxicity (chem.Res.Toxicol., 30, 2017, kumagai et al.).In the present study, we developed a convenient assay based on a combination of an enzyme-linked immunosorbent assay and a biotin-peac5-maleimide assay and used it to determine protein s-oxidation by ros during redox cycling of 9,10-phenanthrenequinone (9,10-pq) and pyrroloquinoline quinone (pqq).S-oxidation of proteins in a mouse liver supernatant was detected during reaction of 9,10-pq or pqq with electron donors such as dithiothreitol or reduced nicotinamide adenine dinucleotide phosphate (nadph), whereas cellular protein oxidation was not observed in the absence of electron donors.These results suggest that the developed assay is useful for the detection of s-oxidation of proteins.

Journal: Biological & pharmaceutical bulletin (2022)
Publication types: Journal Article