syedzayyan/paper_mill_benchmark huggingface dataset:
Improvement in precision grip force control with self-modulation of primary motor cortex during motor imagery.

Motor imagery (mi) has shown effectiveness in enhancing motor performance.This may be due to the common neural mechanisms underlying mi and motor execution (me).The main region of the me network, the primary motor cortex (m1), has been consistently linked to motor performance.However, the activation of m1 during motor imagery is controversial, which may account for inconsistent rehabilitation therapy outcomes using mi.Here, we examined the relationship between contralateral m1 (c m1) activation during mi and changes in sensorimotor performance.To aid c m1 activity modulation during mi, we used real-time f mri neurofeedback-guided mi based on c m1 hand area blood oxygen level dependent (bold) signal in healthy subjects, performing kinesthetic mi of pinching.We used multiple regression analysis to examine the correlation between c m1 bold signal and changes in motor performance during an isometric pinching task of those subjects who were able to activate c m1 during motor imagery.Activities in premotor and parietal regions were used as covariates.We found that c m1 activity was positively correlated to improvements in accuracy as well as overall performance improvements, whereas other regions in the sensorimotor network were not.The association between c m1 activation during mi with performance changes indicates that subjects with stronger c m1 activation during mi may benefit more from mi training, with implications toward targeted neurotherapy.

Journal: Frontiers in behavioral neuroscience (2015)
Publication types: Journal Article
Endoscopic Findings of Gastro-Esophageal Reflux Disease in Elderly and Younger Age Groups.

To determine and compare the clinical features and endoscopic findings of gastro-esophageal reflux disease (gerd) in elderly and younger age groups.materials and methods:the clinical and endoscopic features were evaluated for all patients with gerd between january 2017 and september 2020.The criteria for inclusion were being aged over 65 and under 50 years and having an upper gastrointestinal endoscopy with reflux symptoms resistant to ppi theraphy.The exclusion criteria included prior surgery, age under 18 years, and pregnancy.The diagnosis of gerd was made according to the patients' symptoms.The spss 11.0 for windows pocket program was used for statistical analysis.results:two hundred eighty-six patients aged over 65 years and 261 patients aged below 50 years were enrolled in this study.The mean age of the older group was 68.2 ± 4.5 years and the mean age of the young group was 38 ± 7.2 years.The male/female ratio was 5/3 and 2/1 in the young and older groups, respectively.The older patients had less severe and rare typical symptoms than the young patients.However, significantly more serious endoscopic findings were noted in the older patients compared with the younger patients.conclusion:the older and young patients with gerd were predominantly male and typical reflux problems were less common in older patients with gerd.Older patients had more important endoscopic findings such as hernia, esophagitis, and cancer.

Journal: Frontiers in medicine (2021)
Publication types: Journal Article
Improved method to stratify lymphoma patients with risk of secondary central nervous system involvement: A multicenter retrospective analysis.

Secondary central nervous system (scns) involvement is an infrequent but universally fatal event in diffused large b-cell lymphoma.The occurrence rate of scns involvement is approximately 5% but comes with a poor prognosis ever after.However, existing risk models to predict the incidence and prognosis of these patients with scns involvement lack both efficiency and accuracy.Controversy has also been reported regarding which risk factor may best identify the population with a high cns relapse rate.In this study, we retrospectively analyzed 831 patients with diffused large b-cell lymphoma, diagnosed between march 2008 and june 2018 in tianjin medical university cancer institute and hospital, beijing cancer hospital, and cancer hospital of the university of chinese academy of science.Risk factors and nomogram were identified and established based on fine and gray's competing risk analysis.Among these patients, 55 (6.6%) of them eventually developed scns involvement.The 1- and 2-year incidence for scns involvement were 3.9% and 4.7%, respectively.The median time from de novo diagnosis to cns relapse was 8 months, and the median overall survival of these patients was 28 months.Considering the competing mortality before scns involvement, fine and gray's competing risk model was performed to analyze the characteristics related to scns involvement, and identified risk factors as the multiple extranodal involvements, elevated ldh and amc level, and the involvement of breast, adrenal gland/kidney, pulmonary and bone.Corresponding factors were integrated into the competing nomogram for scns involvement (c-index = 0.778).In conclusion, we present the first predictive nomogram to evaluate the risk to develop scns involvement in de novo dlbcl patients, which may help in both prognostic evaluation and clinical decision for this subgroup.

Journal: Hematological oncology (2023)
Publication types: Multicenter Study;Journal Article
Polysubstance Use Patterns Among High Dose Benzodiazepine Users: A Latent Class Analysis and Differences Between Male and Female Use.

Benzodiazepines (bzds) represent one of the most widely used groups of pharmaceuticals, but if used for long periods of time they are associated with dependence and an increased risk of harmful effects.High-dose (hd) bzd dependence is a specific substance use disorder associated with a poor quality of life.It is especially important to pinpoint differences in hd bzd addict subgroups in order to tailor treatment to the individual's specific needs, also considering possible comorbidities with other substance use disorders.We conducted a study to evaluate hd bzd dependence (converted doses to diazepam equivalents, mg) in an italian sample of 1,354 participants.We also investigated if and to which extent participants co-used other substances (alcohol, tobacco, cannabis/cannabinoids, cocaine, and heroin).We then performed latent class analysis (lca) to identify the use patterns of these substances, finding three classes: participants in class 1 (4.3% of the sample) had the highest probability of also using cocaine and alcohol (polysubstance bzd users); class 2 comprised subjects with the highest probability of being former heroin, cocaine, thc, and alcohol users (former polysubstance bzd users); class 3 represented mono-dependence bzd users (78.5% of the sample) and was the most prevalent among women, while young men were most prevalent in class 1.The present study underlines different characteristics in hd bzd users both concerning other addictions and sex, and also highlights the need for a stricter control of bzd use, ranging from prescriptions to sales.

Journal: Frontiers in psychiatry (2022)
Publication types: Journal Article
Dietary L-theanine supplementation improves lipid metabolism and antioxidant capacity in weaning piglets.

The aim of this study was to explore the effects of dietary l-theanine (lt) supplementation on lipid metabolism and antioxidant capacity in weaned piglets.Twenty-one castrated dly weaning piglets were randomly divided into three groups: a basal diet, a basal diet supplemented with 0.05% and 0.1% lt, respectively.Our data showed that dietary lt supplementation decreased t-cho, tg, ldl-c and apo b levels and increased apo a and hdl-c levels in serum, but decreased the hepatic tg and t-cho contents.Dietary lt supplementation increased the antioxidant capacity in serum and liver, and significantly increased the nrf2m rna level and the nucleus nrf2 protein level, but decreased the m rna level ofkeap1in the liver.In addition, dietary lt supplementation significantly increased hsl enzyme activity and the levels of cpt1 and tba, while decreasing the enzyme activities of lpl and fas in the liver.Furthermore, the m rna levels hmg-co ar,cpt-1aand pparαand the protein levels of phosphorylated-ampk and pgc-1α were increased by lt.Together, our data provide the first evidence that dietary supplementation of lt could improve lipid metabolism and antioxidant capacity in the liver of weaned piglets, and the effect might be mediated by activation of ampk and nrf2 signaling, respectively.

Journal: Animal biotechnology (2022)
Publication types: Randomized Controlled Trial, Veterinary;Journal Article
In VitroBiological Screening ofHartmannia roseaExtracts.

The present study is focused on the assessment of the medicinal therapeutic potential extracts of h.Roseato investigate their pharmacological implications based upon science proofs.The antioxidant activity of fraction of h.Rosea, namely,n-hexane (hr-1), ethyl acetate (hr-2), chloroform (hr-3), andn-butanol (hr-4), was performed by using the dpph radical scavenging method.The cytotoxicity and enzyme inhibition assessment were also performed.All the extracts showed significant antioxidant, antibacterial, and protein kinase inhibition but none of the extracts exhibitedα-amylase inhibition activity.The chloroform extract hr-3 may block a kinase receptor from binding to atp; the lead molecule will be isolated, which may stop cancerous cell growth and demotion of cell division.It is predicted that ethyl acetate, chloroform, andn-butanol extracts of h.Roseacontain polyphenolics, flavonoids, and alkaloids that are biologically effective candidates exhibiting significant cytotoxicity, antioxidant, and antimicrobial activities.They may control oxidative damage in the body tissues and act as potential antidiabetic and anticancer agents.These studies will also be helpful for future drug designing and drug development research.

Journal: BioMed research international (2017)
Publication types: Journal Article
Modified scarf osteotomy for hallux valgus: From a finite element model to clinical results.

Finite element (fe) analysis and clinical follow-up were used to evaluate the efficacy of modified scarf osteotomy for moderate-to-severe hallux valgus (hv).Method we retrospectively evaluated 42 patients (44 feet) who underwent modified rotational scarf osteotomy for moderate-to-severe hv at our institution between january 2010 and january 2019.Radiological indicators and subjective scores were recorded at different time points.To compare the results and elemental characteristics, a fe model of the metatarsophalangeal (mtp) joint that included anatomically realistic geometrical and structural characteristics was built.The biomechanical features and correction differences in dynamic loads as well as the incidence of troughing were estimated.Results both the hallux valgus angle (hva) and intermetatarsal angle (ima) showed significant improvement 6 weeks postoperatively (p 0.05).The subjective scores significantly improved from the preoperative period to the last follow-up.The percentages of troughing and recurrence were remarkably low in our pilot study because of the innate stability of the modified rotated fixation.Conclusion our preliminary findings suggest that modified rotational scarf osteotomy offers sufficient stability, correct hv deformity effectively, and good clinical outcomes for moderate to severe hv.

Journal: Journal of orthopaedic surgery (Hong Kong) (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
COVID-19 Mask Usage and Social Distancing in Social Media Images: Large-scale Deep Learning Analysis.

The adoption of nonpharmaceutical interventions and their surveillance are critical for detecting and stopping possible transmission routes of covid-19.A study of the effects of these interventions can help shape public health decisions.The efficacy of nonpharmaceutical interventions can be affected by public behaviors in events, such as protests.We examined mask use and mask fit in the united states, from social media images, especially during the black lives matter (blm) protests, representing the first large-scale public gatherings in the pandemic.Objective this study assessed the use and fit of face masks and social distancing in the united states and events of large physical gatherings through public social media images from 6 cities and blm protests.Methods we collected and analyzed 2.04 million public social media images from new york city, dallas, seattle, new orleans, boston, and minneapolis between february 1, 2020, and may 31, 2020.We evaluated correlations between online mask usage trends and covid-19 cases.We looked for significant changes in mask use patterns and group posting around important policy decisions.For blm protests, we analyzed 195,452 posts from new york and minneapolis from may 25, 2020, to july 15, 2020.We looked at differences in adopting the preventive measures in the blm protests through the mask fit score.Results the average percentage of group pictures dropped from 8.05% to 4.65% after the lockdown week.New york city, dallas, seattle, new orleans, boston, and minneapolis observed increases of 5.0%, 7.4%, 7.4%, 6.5%, 5.6%, and 7.1%, respectively, in mask use between february 2020 and may 2020.Boston and minneapolis observed significant increases of 3.0% and 7.4%, respectively, in mask use after the mask mandates.Differences of 6.2% and 8.3% were found in group pictures between blm posts and non-blm posts for new york city and minneapolis, respectively.In contrast, the differences in the percentage of masked faces in group pictures between blm and non-blm posts were 29.0% and 20.1% for new york city and minneapolis, respectively.Across protests, 35% of individuals wore a mask with a fit score greater than 80%.Conclusions the study found a significant drop in group posting when the stay-at-home laws were applied and a significant increase in mask use for 2 of 3 cities where masks were mandated.Although a positive trend toward mask use and social distancing was observed, a high percentage of posts showed disregard for the guidelines.Blm-related posts captured the lack of seriousness to safety measures, with a high percentage of group pictures and low mask fit scores.Thus, the methodology provides a directional indication of how government policies can be indirectly monitored through social media.

Journal: JMIR public health and surveillance (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Common and differential neural mechanisms underlying mood disorders.

Despite homogenous clinical presentations between bipolar and unipolar disorders, there are distinct neurobiological differences.Chronicity of illness may be a factor impacting and sustaining certain neural features.The goal of this study was to investigate common and shared neural mechanisms underlying mood disorders, and possible sustained neural changes relating to illness chronicity by investigating a cohort of euthymic patients with bipolar disorder (bd), unipolar depression who had responded to treatment (treatment-sensitive depression, tsd), and a chronically treatment-resistant depressed (trd) group.Methods one hundred and seventy-two participants (40 bd, 39 tsd, 40 trd, and 53 age-gender-matched healthy controls) underwent resting-state f mri scans.Seed-based and independent component analyses were performed to investigate group differences in resting-state connectivity between the four groups.Results all three clinical groups had significantly lower connectivity within the frontoparietal network (fpn) relative to controls.Trd and bd were significantly different from tsd (trd, bd > tsd) but were not significantly different from each other.Trds were also significantly different from both bd and tsd for salience network connectivity with the posterior cingulate (dmn) and the fpn with frontal pole (dmn).Additionally, the bd group exhibited greater dmn-fpn (sg acc-rdlpfc) connectivity relative to trd, tsd, and controls, which was correlated with a previous number of depressive episodes, in the bd group only.Conclusions bd demonstrated shared and differential connectivity features relative to symptomatic trd and euthymic tsd groups.The increased sg acc-rdlpfc connectivity in bd and its correlation with a number of depressive episodes could be a neural feature associated with illness chronicity.

Journal: Bipolar disorders (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Using Brain Imaging to Improve Spatial Targeting of Transcranial Magnetic Stimulation for Depression.

Transcranial magnetic stimulation (tms) is an effective treatment for depression but is limited in that the optimal therapeutic target remains unknown.Early tms trials lacked a focal target and thus positioned the tms coil over the prefrontal cortex using scalp measurements.Over time, it became clear that this method leads to variation in the stimulation site and that this could contribute to heterogeneity in antidepressant response.Newer methods allow for precise positioning of the tms coil over a specific brain location, but leveraging these precise methods requires a more precise therapeutic target.We review how neuroimaging is being used to identify a more focal therapeutic target for depression.We highlight recent studies showing that more effective tms targets in the frontal cortex are functionally connected to deep limbic regions such as the subgenual cingulate cortex.We review how connectivity might be used to identify an optimal tms target for use in all patients and potentially even a personalized target for each individual patient.We address the clinical implications of this emerging field and highlight critical questions for future research.

Journal: Biological psychiatry (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Review
Ectodysplasin A receptor (EDAR) promotes colorectal cancer cell proliferation via regulation of the Wnt/β-catenin signaling pathway.

Colorectal cancer is the second leading cause of cancer mortality worldwide with poor prognosis and high recurrence.Aberrant wnt/β-catenin signaling promotes oncogenesis by transcriptional activation of c-myc and its downstream signals.Edar is characterized as an important effector of canonical wnt signaling in developing skin appendages, but the interplay between edar and wnt signaling in tumorigenesis and progression remains to be elucidated.In this study, we revealed that edar expression is prevalently elevated in colorectal cancer tissues compared with normal tissues.Further analysis suggests there is a strict correlation between edar expression and colorectal cancer progression.Edar silencing by sh rna in colorectal cancer cells showed proliferative suppression via retarding cell cycle at g1 phase.Xenograft mice transplanted with sh edar-transduced tumor cells significantly alleviated tumor burden in comparison with control mice.Furthermore, downregulation of edar was accompanied by reduction of β-catenin, c-myc and other g1 cell cycle regulators, while β-catenin agonist restored the expression of these proteins and overrode the proliferative block induced by edar knockdown.These findings indicate that edar functions as a component of wnt/β-catenin signaling pathway, and is a potential modulator in colorectal carcinogenesis.

Journal: Experimental cell research (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Phosphorescent Neutral Iridium (III) Complexes for Organic Light-Emitting Diodes.

The development of transition metal complexes for application in light-emitting devices is currently attracting significant research interest.Among phosphorescent emitters, those involving iridium (iii) complexes have proven to be exceedingly useful due to their relatively short triplet lifetime and high phosphorescence quantum yields.The emission wavelength of iridium (iii) complexes significantly depends on the ligands, and changing the electronic nature and the position of the ligand substituents can control the properties of the ligands.In this chapter, we discuss recent developments of phosphorescent transition metal complexes for organic light-emitting diode applications focusing solely on the development of iridium metal complexes.

Journal: Topics in current chemistry (Cham) (2017)
Publication types: Journal Article;Review
National characteristics, etiology, and inpatient outcomes of pediatric traumatic brain injury: a KID study.

Traumatic brain injury (tbi) in pediatric patients is a major burden to public health.Understanding clinical associations with severity and short hospitalization (≤ 1 day length of stay) is needed to better inform management paradigms and optimize triage.Methods a retrospective review of the kids' inpatient database (kid) was performed for all data reported between 2006 and 2012 for tbi patients aged ≤ 20 years.Univariate and multivariate regression analyses were performed to identify predictive factors of trauma severity and short hospitalization.Results a total of 220,777 pediatric tbi cases were identified, with the majority of cases being boys (66%) with a mean age of 11.5 years.Mean length of stay was 5.0 days, with 25% discharged within 1 day, and 83% routinely discharged home.In-hospital mortality occurred in 4% of cases.More severe tbi presentations were significantly and independently associated with older age, weekend admissions, hospital transfers, and in patients with chronic conditions and neurological issues (all p < 0.01).There were 38% of admission that were short hospitalizations.Younger age, male gender, less chronic conditions, fall and assault etiologies, and with milder injury severity all significantly and independently predicted greater likelihood of short hospitalization.Conclusions the severity of pediatric tbi admissions to the hospital can be impacted by a number of parameters.Furthermore, there exists a subset of clinical associations for short hospitalization admissions.Proactive identification of these parameters at time of presentation will assist in optimizing the management of pediatric tbi].

Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2022)
Publication types: Journal Article
ML323, a USP1 inhibitor triggers cell cycle arrest, apoptosis and autophagy in esophageal squamous cell carcinoma cells.

Esophageal squamous cell carcinoma (escc) is a common digestive cancer with high mortality rate due to late diagnosis and drug resistance.It is important to identify new molecular target and develop new anticancer strategy.Ml323 is a novel usp1 inhibitor and exhibits anticancer activity against several cancers.Herein, we investigated whether ml323 has some cytotoxity effect on escc cells and explored the underlying mechanisms.Results revealed that ml323 impeded esophageal cancer cell viability and colony formation.Meanwhile, ml323 blocked cells at g0/g1 phase concomitant with the reduced protein level of c-myc, cyclin d1, cdk4 and cdk6.Ml323 treatment also triggered dna damage and active p53.Then, ml323 induced apoptosis by p53-noxa.Additionally, it stimulated protective autophagy.Co-treatment with cq or baf a1, two classical autophagy inhibitors, enhanced the cytotoxity of ml323.These findings suggested that usp1 inhibitor (ml323) could be used as a viable anti-escc approach.

Journal: Apoptosis : an international journal on programmed cell death (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't