syedzayyan/paper_mill_benchmark huggingface dataset:
Image Layout and Schema Analysis of Chinese Traditional Woodblock Prints Based on Texture and Color Texture Characteristics in the Environment of Few Samples

Technology is the means by which all arts, including woodblock prints, are realized.The “kinship” with modern science and technology makes the development history of woodcut art that can also be understood as a technology history.The purpose of the texture expression produced in the creation of contemporary woodcut is to explore the rich texture expression forms made by contemporary representative painters using special material materials and tools in artistic creation, form a painting technique of personalized words, add new aesthetic meaning to art, and lay a foundation for the formation of unique style of contemporary art and the creation and development of woodcut texture.With the development of the times and the change of the public’s aesthetic taste, the traditional pattern of printmaking needs to be properly transformed if it is to adapt to the modern humanistic environment, which also involves the importance of screen layout and pattern analysis of chinese traditional woodcut.Based on the analysis of texture and color texture features in a few-sample environment, this paper proposes an automatic classification method for vignetting texture pictures by extracting the corresponding vignetting coefficients, and through experiments to verify that the proposed silco has good generalization sex.In the algorithm designed in this paper, the experiment shows that the accuracy p has a 64.7% improvement effect, and the recall r has a 67.8% performance improvement.On the whole, the experimental data show that the comprehensive classification accuracy is more than 57.4%.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Image Analysis Application of Motherwort Total Alkaloid Injection in the Treatment of Postabortion Hemorrhage

In order to reduce the possibility of postabortion hemorrhage leading to maternal death, the author studied the image analysis of postpartum hemorrhage based on leonurus total alkaloid injection, combining research results, in order to explore the curative effect of leonurus injection in treating postpartum hemorrhage.After treatment, the time and volume of vaginal bleeding were significantly lower than those in the control group ( p &lt; 0.05 ); it is suggested that the combination of oxytocin and motherwort can effectively reduce the time and volume of vaginal bleeding after medical abortion, conducive to postoperative recovery.The results show that motherwort injection can effectively reduce the amount of bleeding and reduce the risk of postpartum hemorrhage; in addition, adverse reactions have been reduced, and an image analysis consensus has been formed, which is worthy of promotion.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Hyperfractionation versus Conventional Fractionation of Preoperative Intensity-Modulated Radiotherapy with Oral Capecitabine in Locally Advanced Mid-Low Rectal Cancer: A Propensity Score Matching Study

In theory, the hyperfractionated radiotherapy can enhance biological effect dose against tumor and alleviate normal tissue toxicity.This study is to assess the efficacy and safety of preoperative hyperfractionated intensity-modulated radiotherapy (imrt) with oral capecitabine in patients with locally advanced rectal cancer (larc).Methods.We retrospectively screened patients with larc from january 2015 to june 2016.Patients that received hyperfractionated imrt or conventional fractionated imrt were eligible in the hyperfractionation (hf) group or conventional fractionation (cf) group, respectively.The primary outcome was the complete response rate.Secondary outcomes included toxicity, postoperative complications, anus-reservation operation rate, local recurrence and distant metastases rate, overall survival (os), cancer-specific survival (css), and disease-free survival (dfs).Results.335 patients were included in the analysis.The complete response rate for the hyperfractionated and conventional fractionated imrt was 20.41% vs.23.47% ( p = 0.583 ).The anus-reservation operation rate was 68.37% vs.65.31% ( p = 0.649 ).There were no cases of grade 4 toxicity during radiotherapy; the rate of grade 3 toxicity and postoperative complications was both comparable between groups.However, in the cf group, more patients had a second operation due to complications (0.0% vs.5.68%, p = 0.011 ).The cumulative local regional recurrence and distant metastases rates of the hf group and cf group were 5.10% vs.9.18% ( p = 0.267 ) and 22.45% vs.24.49% ( p = 0.736 ), respectively.The 5-year os, css, and dfs in the hf group and cf group were 86.45% vs.73.30% ( p = 0.503 ), 87.34% vs.75.23% ( p = 0.634 ), and 70.80% vs.68.11% ( p = 0.891 ), respectively.Conclusions.The preoperative hyperfractionated imrt with oral capecitabine, with an acceptable toxicity and favorable response and survival, could reduce the rate of secondary surgery.

Journal: Journal of Oncology (2022)
Publication types: Research Article;
Hub Gene Screening Associated with Early Glaucoma: An Integrated Bioinformatics Analysis

Primary open-angle glaucoma (poag) is the most common type of glaucoma.The potential influence of some degs on the progression of poag was still incomplete.In this study, we integrated transcriptome data with clinical data to investigate the relationship between them in poag patients.Methods.The gene expression profile (gse27276) from gene expression omnibus (geo) was used to identify degs.The limma package of r was used to identify the degs (diboun et al., 2006).The adjusted p values (adj p value) were calculated instead to avoid the appearance of false-positive results.Genes with |log2 fold change (fc)| larger than 1 and adj p value &lt; 0.01 were taken as degs between ph and pc samples.Go (gene ontology) function and kegg (kyoto encyclopedia of genes and genomes) pathway enrichment analyses of the degs were performed.Protein-protein interactions (ppis) of the degs were constructed.Results.A total of 182 degs were identified through our analysis, of which 119 genes were upregulated and 63 genes were downregulated.Go enrichment analysis illustrated that these degs were mostly enriched into haptoglobin binding, antioxidant activity, and organic acid binding.Kegg enrichment analysis illustrated that these degs were mostly enriched into staphylococcus aureus infection.The most significant module was identified by mcode consists of 8 degs, and bcl11a is the seeded gene.The second most significant module consists of 5 degs, and il1rn is the seeded gene.Conclusion.Our results demonstrate the potential influence of some degs on the progression of poag, providing a comprehensive bioinformatics analysis of the pathogenesis, which may contribute to future investigation into the molecular mechanisms and biomarkers.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Grading Evaluation of Cardiotoxicity in Patients with Breast Cancer Treated with Adjuvant Paclitaxel Anthracycline/Cyclophosphamide Chemotherapy: A Meta-Analysis

The cardiac safety of concurrent treatment with anthracycline (a), cyclophosphamide (c), and paclitaxel (t) in an adjuvant bc treatment regimen is still under debate.In this study, we aimed to determine cardiotoxicity events following act chemotherapy among operable breast cancer patients without her2-positive.Methods.We searched pub med and the cochrane library for rcts prior to july 2019 evaluating the cardiac impairment of act chemotherapy regimens in bc patients.The search terms were “bc,” “chemotherapy,” “docetaxel or “doxorubicin,” “paclitaxel,” and “cyclophosphamide.” cardiotoxic events included lvef decline ≥ 10 points, congestive heart failure (chf), and cardiac death.Results.In total, 12 studies with 4032 subjects were included in this meta-analysis, and all patients received act regimen.The analysis results indicated that lvef decrease ≥ 10 points was the most common cardiotoxic event (16%; (95% ci (8%–24%)) with χ 2 = 95.75 , p &lt; 0.001 , i 2 = 95.8 % ).Chf showed the lowest rate (1%; (95% ci (0%–1%)) with χ 2 = 8.00 , p = 0.433 , i 2 = 0.0 % ).Subgroup analysis demonstrated that the incidence of chf due to a → c → t chemotherapy regimen was lower than that of other events, however, without significance.No significant difference was observed in the occurrence of cardiac death.Conclusion.The act regimen in patients with her2-negative bc was associated with an increased risk of adverse cardiactoxic events.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Genomic and Clinical Analysis of Children with Acute Lymphoblastic Leukemia

This study investigated the types and significance of mutant genes in children with acute lymphoblastic leukemia (all).Methods.The gene sequencing data of 89 all children were retrospectively analyzed.Log-rank test was used to analyze the effect of different numbers of mutant genes on the clinical characteristics of the patients and disease.Results.Known gene mutations were detected in 64% (57/89) of the children, including one gene mutation in 31% and two or more gene mutations in 33% of the patients.Gene sequencing showed that most mutations occurred in kras (17%), nras (15%), flt3 (7%), tp53 (7%), and ptpn11 (7%), and functional clustering analysis showed that most were signaling pathway genes (50%).In the overall cohort, no association was found between clinical characteristics and gene mutation.The children were then classified into three groups: group a (no gene mutation), group b (one gene mutation), and group c (two or more gene mutations).Correlation analysis showed that group a had significantly more children with medium risk all ( p = 0.037 ), and group c had markedly more children with high risk all ( p = 0.001 ).Further analysis showed that children with mutant genes took significantly more time to enter the maintenance phase than children without mutations.Conclusion.Children with all had a high gene mutation rate, especially in kras and nras genes, and the mutant genes were mainly signal pathway-related.The gene mutations were significantly correlated with clinical phenotype and the time taken to enter the maintenance phase.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
General Surgery Clinical Information Management System Based on Intelligent Data Management

In order to improve the effect of surgical clinical information management, this paper combines the intelligent data management technology to construct the general surgery clinical information management system.Based on the design and development of general surgery clinical medical case information management system, this paper studies the mutual conversion between xml data and relational data, and designs a clinical medical case information management system based on the design idea of layered architecture.The clinical medical case information management system mainly adopts the modular design idea and adopts a digital microscopic image storage mode based on hdfs architecture.After building the system function structure, the system effect is verified by simulation test.From the experimental statistical results, it can be seen that the general surgery clinical information management system based on intelligent data management proposed in this paper has a good effect.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Functional Characterization of a Missense Variant of MLH1 Identified in Lynch Syndrome Pedigree

Lynch syndrome (ls) is the most common hereditary colorectal cancer (crcs) inherited in an autosomal-dominant manner.Here, we reported a multigeneration chinese family clinically diagnosed with ls according to the amsterdam ii criteria.To identify the underlying causative gene for ls in this family, whole-exome sequencing (wes) was performed.A germline missense variant (c.2054c&gt;t:p.s685f) in exon 18 of mlh1 was successfully identified by wes.Sanger sequencing verified the results of wes and also confirmed the cosegregation of the mlh1 missense variant in all affected members of the family including two unaffected family members.Bioinformatic tools predicted the identified mlh1 variant as deleterious.Immunohistochemistry (ihc) staining showed loss of mlh1 and pms2 protein expression.In vitro expression analysis also revealed that the identified mlh1 missense variant (c.2054c&gt;t:p.s685f) results in reduced expression of both mlh1 and pms2 proteins.Based on the american college of medical genetics and genomics (acmg) guidelines, the missense mutation c.2054c&gt;t in mlh1 was classified as a “pathogenic” variant.Two unaffected family members were later recommended for colonoscopy and other important cancer diagnostic inspections every 1-2 years as both were at higher risk of ls.In conclusion, our findings widen the genotypic spectrum of mlh1 mutations responsible for ls.This study increases the phenotypic spectrum of ls which will certainly help the clinicians in diagnosing ls in multigeneration families.This study also puts emphasis on the importance of genetic counselling for the benefit of asymptomatic carriers of mmr gene variants who are at higher risk of ls.

Journal: Disease Markers (2020)
Publication types: Research Article;
Ferroptosis: A Novel Therapeutic Direction of Spinal Cord Injury

An injury to the spinal cord results in a crucial central nervous system event that further causes irreversible impairment or loss of motor, autonomic, and sensory functions.A progressive pathophysiological cascade following spinal cord injury (sci) includes ischemia/reperfusion injury, oxidative stress, proapoptotic signaling, peripheral inflammatory cell infiltration, and glutamate-mediated excitotoxicity, and regulated cell death.These complex pathological and physiological changes continue to cause cell injury over the long-term and severely limit the efficacy of clinical treatment strategies in restoring the injured nervous system.Ferroptosis is a nonapoptotic, iron-regulated kind of cell death that has recently been discovered.It is distinguished by iron overload-induced toxic lipid peroxidation associated with mitochondrial morphological changes during the cell death process.For example, after sci, iron overload activates the reactive oxygen species generation, dysregulation of glutathione/glutathione peroxidase 4 (gsh/gpx4) metabolism, and accumulation of lipid peroxides, which cause lipid membrane deterioration and ferroptosis.Conversely, knockout or differential expression of key genes and application of lipid peroxidation inhibitors and iron chelators (e.g., deferoxamine) (e.g., srs-16-86) can block ferroptosis and promote neuronal repair for functional recovery after sci.Although the findings of numerous investigations have been confirmed the importance of ferroptosis in several human neurologic sicknesses and its potential in sci, the mechanism of ferroptosis and its application in sci has not been elucidated.This review highlights current ferroptosis research and its impact on sci, as well as the key molecular mechanism of ferroptosis in promoting the recovery from sci.Understanding ferroptosis’ process and function in sci could provide useful insight into the treatment and avoidance of such a destructive injury.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Experimental Study on Alleviating Sports Injury through Data Screening of Functional Motor Biological Images

In order to better reduce sports injury, a method based on functional motion biological image data is proposed.Through performing functional motion screening test on wushu athletes, including 7 items of test, each athlete is given a score according to the test standard.This paper summarizes the mistakes and deficiencies of common movement patterns of athletes and makes different intervention plans to improve the effect of sports injury screening.The results show that, at p &gt; 0.001 , there was a significant difference, and the experimental group fms total score (15.02 ± 3.7) was lower than the control group fms total score (18.51 ± 1.45).The recognition rate of the system is higher than that of the system based on single feature, and the recognition performance is better than that of the standard svm and knn recognition methods.It is proved that the design of the system is feasible, reliable, and effective.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Environmental and Genetic Factors in the Pathogenesis of COPD in the Road-Working Population

Chronic obstructive pulmonary disease (copd) is a typical heterogeneous condition caused by environmental and genetic risk factors.Objectives.We investigated extrinsic (environmental) and intrinsic (genetic) factors contributing to the development of copd in a nonsmoker road-working population in northeast china.Method.The target population was divided into a copd group and an exposed control group.Another healthy nonroad working nonsmoker control group was also included for environmental factor comparison.Peripheral blood was collected and analyzed using inductively coupled plasma mass spectrometry for inorganic elements of pm2.5, and microarray, rt-pcr, and multiplex elisa for genetic factors.Results.Forty-three copd road workers, thirty-nine non-copd road workers, and 52 age and gender-matched healthy nonroad workers were enrolled.There were significantly higher levels in all 24 inorganic elements in the copd group compared with the healthy control group except potassium and manganese, while the majority of inorganic elements were similar between the copd group and the exposed control group except in aluminum and cobalt.There were 39 genes showing significant differences between the copd group and the exposed control group.Collagen, type xv, alpha 1 (col15a1), meis homeobox 1 (meis1), carbonyl reductase 3 (cbr3), and amine oxidase, copper containing 3 (aoc3) were confirmed by rt-pcr to be differentially expressed.Their correlations with blood cytokines were also evaluated.Conclusions.Aluminum might contribute to the development of copd in the road-working population.Cbr3 and aoc3 seem expressed in different patterns than previously reported, evidenced by their correlation with proinflammatory and anti-inflammatory cytokines.

Journal: Disease Markers (2021)
Publication types: Research Article;
Efficacy Evaluation of Inflammatory Mediators in the Treatment of Multiple Myeloma with Daratumumab

This study aimed to investigate the regulatory ability and clinical therapeutic effect of daratumumab on inflammatory mediators in patients with multiple myeloma.Method.The multiple myeloma public genetic data array download gse125361 dataset was collected.The go analysis and kegg analysis were performed on the differential genes to elucidate the multiple myeloma cytokine-related gene pathways.Daratumumab is a cd38 monoclonal antibody used to treat multiple myeloma.Patients with newly diagnosed multiple myeloma were treated with monoclonal antibodies containing cd38, and the control group was treated with a regimen without daratumumab.The serum levels of il-2, il-4, il-6, il-10, tnf-α, and ifn-γ were measured in the two groups before and after treatment and the therapeutic effects of the two groups were compared.Result.The kegg analysis showed that the th17 cell differentiation, apoptosis, and cytokine-cytokine receptor interaction pathways were differentially expressed in multiple myeloma.The expression levels of serum il-2, il-6, il-10, and tnf-α in patients in the daratumumab group were lower than those in the control group after chemotherapy.The overall effective rate of patients treated with daratumumab after chemotherapy was higher than that of the control group.Conclusion.Daratumumab can effectively improve the levels of il-2, il-6, il-10, and tnf-α in patients with multiple myeloma and improve the therapeutic effect.

Journal: Journal of Oncology (2022)
Publication types: Research Article;
Effect of Intelligent Medical Data Technology in Postoperative Nursing Care

Surgery is one of the larger wounds in conventional surgery, and patients often experience different pain and postural discomfort after surgery.With the ever‐changing standards of medical care and patient care requirements, providing high‐quality care to postoperative patients is an important measure to reduce complications and promote rapid recovery.However, in the traditional postsurgical nursing methods, there are often the phenomenon that wrong patients are connected, patient data is messy, and medicines are counted incorrectly, which directly leads to a rapid decline in nursing efficiency.In the context of the rapid development of artificial intelligence and big data, intelligent medical data analysis technology has gradually been integrated into the medical field.This paper analyzes and studies the application effect of intelligent medical data analysis technology in postoperative nursing.It is aimed at changing the traditional postoperative nursing methods and improving nursing efficiency, and it provides important suggestions for the development of postoperative nursing in the new era.Combining big data and internet of things technology, this paper builds a smart medical internet of things framework and an intelligent postoperative care system and uses machine learning algorithms to preprocess relevant medical data.The final experimental results show that the intelligent medical data analysis technology has a good effect in improving the nursing efficiency after surgery, and the nursing efficiency has increased by 6.9%.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Effect of Early Cognitive Training Combined with Aerobic Exercise on Quality of Life and Cognitive Function Recovery of Patients with Poststroke Cognitive Impairment

To explore the effect of early cognitive training combined with aerobic exercise on quality of life (qol) and cognitive function recovery of patients with poststroke cognitive impairment (psci).Methods.Ninety psci patients treated in our hospital from april 2019 to april 2020 were selected as the subjects and were divided into the experimental group (eg) and control group (cg) according to the admission order, with 45 cases each.Patients in cg received conventional health education combined with rehabilitation training, and those in eg accepted early cognitive training combined with aerobic exercise so as to evaluate the clinical effect of different intervention modes on psci patients.Results.Compared with cg after intervention, eg obtained an obviously higher stroke specific quality of life scale (ss-qol) score, montreal cognitive assessment (mo ca) score, barthel index (mbi) (bi) score and functional independence measure (fim) score (p &lt; 0.001), and obviously shorter time for completing tmt-a and tmt-b (p &lt; 0.001).Conclusion.Performing early cognitive training combined with aerobic exercise for psci patients can effectively improve their qol and promote the recovery of cognitive function.Compared with conventional health education combined with rehabilitation training, this mode presents a higher application value.Further study will be conducive to establishing a better solution for patients.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Clinical Study;