syedzayyan/paper_mill_benchmark huggingface dataset:
A Meta-Analysis of the Influence of Tumor Necrosis Factor-α-308 Gene Polymorphism on Liver Cirrhosis

Cirrhosis is an active hepatic inflammation process of the liver considered as the serious phase of different liver injuries.Epidemiological studies have evaluated the possible association between tnf-α-308g/a gene polymorphism and liver cirrhosis.In this study, we have furthered the study to assess the exact association of tnf-α-308g/a gene polymorphism with liver cirrhosis susceptibility by integrating all available data.Eligible case-control studies were carried out from the establishment of the project to september 2021.Published literature from multiple databases was retrieved, collected, and analyzed by two investigators independently.Odds ratios (ors) and 95% confidence intervals (cis) were calculated for every study.Review manager 5.2 and stata 15.0 software were used for meta-analysis and stability was assessed by both subgroup analysis and sensitivity analysis.Begg’s funnel plot and egger’s regression across the studies were also explored.We examined 22 case-control studies with 2683 cirrhosis patients and 2905 normal controls in four genetic models (ga vs.Gg: or = 0.95, 95%ci: (0.70, 1.30); aa vs.Gg: or = 1.11, 95% ci: (0.66, 1.85), ga + aa vs.Gg: or = 1.00, 95% ci: (0.73, 1.37); aa vs.Ga + gg: or = 1.07, 95%ci: (0.70,1.63)).Tnf-α-308g/a gene polymorphism was relatively independent, and the results did not show a significant difference between the two groups.In the subgroup analysis by etiological classification of liver cirrhosis, cirrhosis after hcv infection was positively associated with the risk of tnf-α-308g/a polymorphism (aa vs.Gg: or = 3.02, 95% ci: (1.15, 7.88), aa vs.Ga + gg: or = 2.68, 95% ci: (1.04, 6.95)).The meta-analysis showed tnf-α-308g/a gene polymorphism might not have affected susceptibility for liver cirrhosis.Nevertheless, further and well-designed studies were needed to confirm the findings.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Meta-Analysis;
Cultural Product Appearance Design Based on Improved Multiobjective Optimization Algorithm

Cultural creative products are important carriers of cultural heritage and play a very important role in the inheritance, innovation, and dissemination of culture.At present, cultural and creative products emerge in an endless stream with a variety of patterns.No matter in function or form, most of them still follow the traditional design method, and the product style is relatively single, the identification is not strong, and the heat is not enough.Therefore, in the design of cultural and creative products, it is far from meeting the requirements of the flexible and changeable market to only use culture to conform to the consideration of product form.Instead, it should also take into account the personalized and diversified needs of users for products and carry out in-depth practical research on their functionality and imagery.Therefore, this study proposes an improved multiobjective optimization algorithm, combined with the vgg (visual geometry group) model, to study and design the appearance characteristics, color collocation, and design aesthetic feeling of cultural and creative products.This study hopes that through the continuous attempts of cultural and creative product design, people can feel the splendid cultural connotation civilization again and provide new ideas and good for the advanced theme design of traditional chinese culture.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
The Chronotropic Function of Propofol and the Underlying Mechanism in Rabbits

The report of bradycardia caused by propofol is increasing.In the experiment, we investigated the chronotropic function of propofol and the underlying mechanism.Rabbits of both sexes were randomly divided into 4 groups: propofol 5 mg/kg group, 10 mg/kg group, 15 mg/kg group, and sham group.Heart rate and frequency of vagal efferent discharge were recorded before the injection and 0, 0.5, 1, 2, and 10 min after the injection through intravenous mode.Then, their hearts were removed, and sinoatrial nodes were dissected.The action potentials of the sinus node pacemaker cells were recorded by the intracellular glass microelectrode technique, and the sinoatrial (sa) node was exposed to propofol 1, 3, 5, and 10 μm respectively.The action potentials were recorded after the sinoatrial nodes were exposed to each concentration of propofol for 15 min.Our results show that the heart rate significantly decreased, and the vagal efferent discharge was significantly increased at 0, 0.5, 1, and 2 min after the injection, respectively.Besides, as the dose increases, the magnitude of change shows a dose-dependent manner.Propofol exerts a negative chronotropic action on sinoatrial node pacemaker cells.The drug significantly decreased apa, vdd, rpf, and prolonged apd90 in a concentration-dependent manner.These effects may be the main mechanism of propofol-induced bradycardia in clinical study.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Silencing MR-1 Protects against Myocardial Injury Induced by Chronic Intermittent Hypoxia by Targeting Nrf2 through Antioxidant Stress and Anti-Inflammation Pathways

Patients with obstructive sleep apnea hypopnea syndrome (osahs) often have cardiac insufficiency mainly due to hypoxia/reperfusion injury caused by chronic intermittent hypoxia (cih).Inflammation and oxidative stress are involved in the cardiovascular events of osahs patients.Studies have found that myofibrillation regulator-1 (mr-1) participates in the pathological process of osahs-induced myocardial injury, but the specific mechanism is still unclear.Methods.We used a cih-induced rat model to simulate the process of osahs disease.Indices of myocardial injury, inflammation, and oxidative stress were detected using quantitative pcr and enzyme-linked immunosorbent assay (elisa).After administration of adenoassociated viral vector (aav) encoding silencing rna against mr-1, we examined expression of the classic antioxidant stress pathway protein nf-e2-related factor 2 (nrf2) using western blotting.Results.We found that levels of serum inflammatory factors tumor necrosis factor (tnf)-α, interleukin (il)-1β, il-6, and il-8 were increased, and we further observed disturbance of the oxidative stress system, in which the content of reactive oxygen species (ros), superoxide dismutase (sod), reduced glutathione (gsh), and malondialdehyde (mda) was enhanced in cih-induced rats.Subsequently, we detected that expression of nrf2 and heme oxygenase-1 (ho-1) was slightly increased, while the expression of kelch-like ech-associated protein 1 (keap-1) was significantly increased in the cih model.Interestingly, after administration of silencing mr-1 aav, the elevated levels of inflammatory factors were reduced, and the disordered oxidative stress system was corrected.Additionally, the expression of nrf2 and ho-1 was distinctly increased, but the high expression of keap-1 was decreased.Conclusions.Our research results demonstrate that silencing mr-1 rescued the myocardium the injury from inflammatory and oxidative stress in cih-induced rats by administration of the nrf2 signaling pathway.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Construction of Algorithm Model in Artificial Intelligence Interactive Art Teaching Evaluation System from the Perspective of Core Literacy

Art teaching is not only an important part of basic education but also an important subject of core literacy education, and the cultivation of core literacy is also a long and lasting process.In order to change the original teaching mode, reform the teaching concept, and cultivate high-quality all-round talents, this paper integrates artificial intelligence interactive teaching method into the art teaching process from the perspective of core literacy, which can not only increase the classroom interaction, improve students’ enthusiasm, and conduct multidimensional evaluation on students’ art work performance, moral sentiment, appreciation ability, creativity, and imagination.While paying attention to cultivating and improving students’ comprehensive quality and ability, the all-round development of students’ moral, intellectual, physical, artistic, and labor ability is improved.

Journal: Mobile Information Systems (2022)
Publication types: Research Article;
Construction and Analysis of College Students’ Entrepreneurship Guidance Model from the Perspective of Ideological and Political Education under Big Data

The idea of infusing entrepreneurship into education has incited much enthusiasm in the last few decades.A myriad of effects have been stated to result from this, including economic growth, job creation, and increased societal resilience, as well as personal growth, increased school involvement, and improved equality.However, in addition to the purported favorable consequences, putting this theory into practice has presented major challenges.The study aims to improve the success rate of college students' entrepreneurship and strengthen their entrepreneurship education.First, two aspects of the current state of political and ideological education are examined: ideological education and entrepreneurship education, and ideological education and big data technology.Next, ideological education, entrepreneurship education, and big data are integrated to implement an impact index evaluation model of college students' entrepreneurship education from the perspective of the internet under big data.Finally, based on the implemented model, seven influencing indicators of entrepreneurship education curriculum, practical education, educational equipment, educational awareness, basic ability, social ability, and data usability are obtained.Through detailed analysis experiments, it is found that three factors have the greatest impact on college students' entrepreneurship education, including basic ability, data usability, and psychological pressure resistance in the face of difficulties.The results show that the cultivation of basic entrepreneurial ability and the development of psychological quality should be enhanced in college students' entrepreneurship education, providing a definite reference base for college students' entrepreneurship education.

Journal: Mobile Information Systems (2022)
Publication types: Research Article;
Regional Differences and Convergence of Urban-Rural Integration Development from the Perspective of Factor Flow

Based on the panel data of thirty‐one provinces in china from 2003 to 2020, we constructed an evaluation index system of urban‐rural integration development level from the perspective of factor flow.The combined weighting model of gi and critic were used to evaluate the regional urban‐rural integration development.The coefficient of variation and panel fixed effect model was used to explore convergence, absolute convergence, and conditional convergence.The impact of capital, labor, and technology factor flow on the convergence of urban‐rural integration development level was further investigated.In addition, the difference analysis in time scale and impulse response function analysis was performed to explore the regular pattern of factor flow on the convergence of urban‐rural integration development.The main conclusions were as follows: first, the growth of urban‐rural integration development had an absolute convergence trend and tended to conditional convergence faster.Second, the capital flow positively affected the convergence of urban‐rural integration development, while labor and technology flow had a slowing effect on the convergence of urban‐rural integration development at this stage.Third, the impact of factor flow on the convergence of urban‐rural integration development was dissimilar during different phases.The convergence rate of urban‐rural integration development after 2012 was drastically slower than before.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
Quality Care Alleviates Behavioral Cognitive Impairment and Reduces Complications in Elderly Patients with Cardiovascular and Cerebrovascular Diseases

Cardiovascular and cerebrovascular disease (ccvd) remains the most common factor of death around the world.Nursing care plays a key role in the recovery of patients with ccvd.This study was to explore the application of quality care in aged patients with ccvd.Methods.Totally, 74 aged ccvd patients admitted from june 2018 to june 2019 in dongying people’s hospital were randomly assigned in 2 groups with the same treatment.The control group was treated with routine care intervention, and the observation group was treated with quality care intervention for 12 weeks.Meanwhile, the frequency of agitation behaviors and cognitive ability were assessed, and complication was counted.Results.The observation group showed decreased cohen-mansfield agitation inventory (cami) scores from 47.31 ± 8.27 to 38.73 ± 6.94, raised mini-mental state examination (mmse) scores from 15.01 ± 3.9 to 19.34 ± 3.15 and montreal cognitive assessment (mo ca) scores from 16.92 ± 5.48 to 20.37 ± 4.16, and reduced complications after quality care intervention.Conclusion.Quality care intervention exerted a better application effect on aged ccvd patients, along with reduction of agitation, improvement of mental condition and behavioral cognitive function, and reduced complications.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Paeoniflorin Attenuated TREM-1-Mediated Inflammation in THP-1 Cells

Sepsis is caused by bacterial infections or viral infections.Clinically, there exist confirmed or highly suspected infection foci.Mortality caused by septic shock remains in a high rate even though antibiotic treatment works effectively.In this study, we treat thp-1 cells with 1 ug/m l lps (lipopolysaccharide) and add paeoniflorin or lr-12 inhibitor.Trem-1 (triggering receptor expressed on myeloid cells-1), il-6, il-1β, and tnf-α (tumour necrosis factor alpha (a)-cachectin) were detected by elisa and q rt-pcr, and western blotting is performed to detect related proteins in the nf-κb signaling pathway.As a result, paeoniflorin can significantly reduce the production of lps-stimulated trem-1 as well as inflammatory factors and attenuate the phosphorylation of nf-κb signaling pathway-related factors, such as p65 and iκbα.At the same time, the combined effect of paeoniflorin and lr-12 is more significant.The results of this study solidly prove that paeoniflorin plays a role in inhibiting trem-1-mediated inflammation and the nf-κb pathway could be a potential mechanism of action.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Exploring the Effect of Enbrel Softgels on PWI Indicators in VCIND Patients

To investigate the effect of enbrel softgels on the head nuclear magnetic (pwi) indices in patients with vascular cognitive impairment-no dementia (vascular cognitive impairment-no dementia, vcind).Methods.Patients with confirmed vcind hospitalized in the department of neurology of the affiliated hospital of hebei university from april 2017 to april 2019 were included in the study, and they were divided into experimental and control groups (30 patients in each group) according to the difference of interventions.The pwi examination and neuropsychological assessment were performed at the beginning of the experiment, 12 w after treatment, and 48 w after treatment in the two groups.Score differences between the two groups and the preliminary demonstration of the clinical value of the mmse and adas-cog in the diagnosis of vcind.Results.(1) the difference in pwi positivity rate between the two groups at the beginning of the experiment was not statistically significant ( p &gt; 0.05 ); the pwi positivity rate in the experimental group at 12 w was significantly lower than that in the control group ( p &lt; 0.05 ); the difference in pwi positivity rate between the two groups at 48 w was not statistically significant ( p &lt; 0.05 ); (2) the mmse scores of patients in the experimental group at 12 w and 48 w were higher than those in the control group, and the adas-cog scores were lower than those in the control group ( p &lt; 0.05 ).(3) the diagnostic aucs of mmse and adas-cog for vcind were 0.7960 (95% ci = 0.6411–0.9508, p = 0.0037 ) and 0.9291 (95% ci = 0.8390), respectively (95% ci = 0.8390–1.000, p &lt; 0.0001 ).Conclusion.The addition of enbrel softgels to concomitant therapy in vcind patients can lead to changes in their pwi imaging indicators, which in turn can have a significant impact on their neuropsychological indicators, and quantitative analysis scales such as the mmse and adas-cog can be considered for the diagnostic treatment of vcind.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Clinical Study;
Clinical Effect of Qili Qiangxin Capsule Combined with Sacubitril-Valsartan in Patients with Chronic Heart Failure

The clinical effect of qili qiangxin capsule combined with sacubitril-valsartan on patients with chronic heart failure was studied.We selected 108 patients with chronic heart failure in our hospital from march 2016 to january 2020 and divided them into a control group and a study group according to the random table method, with 54 cases in each.The control group took sacubitril and valsartan orally, and the study group took qili qiangxin pill on the basis of sacubitril and valsartan.The course of the treatment for 2 groups is 4 weeks.We compared the total effective rate of the treatment of the 2 groups for 4 weeks, cardiac function (left ventricular end-systolic volume (lvesv), left ventricular end-diastolic volume (lvedv), and left ventricular ejection fraction (lvef)) before and after 4 weeks of treatment, 6 min walking distance (6mwt), changes in c tn i and nt-pro bnp levels, and adverse reactions.The total effective rate in the study group (90.74%) is higher than that in the control group (72.22%) ( p <0.05).After 4 weeks of treatment, the study group lvesv (45.23 ± 2.98 mm) and lvedv (43.38 ± 4.01 mm) are lower than those of the control group ((49.98 ± 2.56 mm) and (50.75 ± 3.49 mm), respectively), while lvef (47.38 ± 2.78%) is higher than that in the control group (42.08 ± 3.24%) ( p < 0.05).After 4 weeks of treatment, the study group 6mwt (476.58 ± 31.25 m) of patients with chronic heart failure is higher than that of the control group (396.52 ± 24.52 m) (p <0.05).After 4 weeks of treatment, the study group serum c tn i (0.36 ± 0.12 μg/l) and nt-pro bnp (276.91 ± 30.12 pg/ml) of patients with chronic heart failure are lower than those in the control group (0.87 ± 0.25 μg/l) and (367.48 ± 48.57 pg/ml) ( p <0.05).There is no significant difference between the adverse reactions in the two groups ( p > 0.05).Conclusion: xinbao pills combined with sacubitril and valsartan have a good effect on patients with chronic heart failure, which can improve the heart function and exercise endurance and reduce serum c tn i and nt-pro bnp levels.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Clinical Study;
ZNF488 Promotes the Invasion and Migration of Pancreatic Carcinoma Cells through the Akt/mTOR Pathway

Studies have demonstrated that zinc finger protein 488 (znf488) is highly expressed in pancreatic carcinoma (pc), but its effect on pc and its molecular mechanism remains unclear.Methods.Real-time fluorescent quantitative pcr (rt-q pcr) was employed to detect the znf488 expression in pc patients’ cancer tissues and cell lines.After interfering with or overexpressing znf488 in panc-1 and as pc-1 cells, respectively, the cck-8, cell cloning, transwell, and scratch assays were performed to detect cell proliferation, cell viability, invasion ability, and migration ability.In addition, western blot was applied to assess the protein expression of akt, p-akt, m tor, and p-m tor in the akt-m tor pathway.Results.The znf488 expression was evidently raised in pc tissues and cell lines, and the star base v3.0 database indicated that the higher the znf488 expression, the lower the survival rate of pc patients.Furthermore, we discovered that overexpressing znf488 can markedly promote the proliferation, invasion, and migration of pc cells.At the same time, highly expressed znf488 distinctly increased the p-akt and p-m tor expressions and the p-akt/akt and p-m tor/m tor ratios.However, after knocking down the znf488 expression, it had the opposite results.In addition, the akt agonist sc79 can alleviate the effect of znf488 knockdown on akt/m tor pathway-related proteins, while akt inhibitor azd5363 had the opposite effect.Conclusion.Znf488 could promote the proliferation, invasion, and migration of pc cells, and its mechanism may be related to the activation of the akt/m tor pathway.This study demonstrated that znf488 could be used as a molecular target for diagnosing and treating pc.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
X-Ray Cephalometric Analysis of the Effects of Angle Class II and III Malocclusion on the Upper Airway Width and Hyoid Position between Parents and Children of Uygur Nationality

The objective of this paper is to analyze the effect of angle class ii and iii malocclusion on the sagittal diameter of the upper airway between parents and children of uygur nationality and to compare the degree of influence.Methods.29 uygur adolescents with malocclusion and their fathers (mothers) were selected as our subjects via x-ray cephalometric radiograph to analyze the difference between the upper airway sagittal dimension and normal occlusion and compare the influence of malocclusion on the upper airway between parents and children.Results.Compared with normal group, the vertical distance from the hyoid point to orbital-ear plane (h-fh) and vertical distance from hyoid point to the mandibular plane (h-mp) in angle class ii malocclusion elevated signally, while the vertical distance from hyoid point to anterior cervical plane (h-vl), pns-upw, h-fh, and h-mp decreased significantly; compared with normal group: the distance between the posterior nasal spine and the upper pharynx wall (pns-upw), h-fh, and h-mp in angle class iii malocclusion visually reduced, while pas, and horizontal distance from the hyoid point and center point of sella turcica to orbital-ear foot (h-s), increased markedly.The impact of class ii malocclusion on parents’ u-mpm was greater than their children.Conclusion.The oropharyngeal space of upper airway becomes smaller and hyoid shifts downwards due to class ii malocclusion.Class iii malocclusion results in decreased nasopharyngeal gap with hyoid to shift upward.The influence of class ii malocclusion on the upper pharyngeal tract of parents was greater than their children.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;