syedzayyan/paper_mill_benchmark huggingface dataset:
Fut7 Promotes Adhesion and Invasion of Acute Lymphoblastic Leukemia Cells through the Integrin/Fak/Akt Pathway

To investigate the role and mechanism of n-fucosyltransferase vii (fut7) in acute lymphoblastic leukemia (all).Methods.Bone marrow tissues were collected from patients with all and children with immune thrombocytopenic purpura (control) hospitalized in our hospital during the same period.Then, the fut7 expression in bone marrow tissues was detected by q rt-pcr and western blotting.Human all cell strain jurkat was cultured, and after knockdown or overexpression of fut7, cell proliferation, apoptosis, adhesion and invasion were examined by mtt assay, flow cytometry, fibronectin adhesion assay and transwell, respectively; the protein expression level of integrin α5, integrin β1, p-fak, and p-akt was tested by western blotting.Results.The fut7 expression was up-regulated in bone marrow cells of all patients.After knockdown of fut7, the proliferation, adhesion and migration ability of all cells were significantly reduced, and apoptosis was increased, while the overexpression of fut7 obtained the opposite results.Moreover, the overexpression of fut7 also promoted the protein expression of integrin α5, integrin β1, p-fak, p-akt.Conclusion.Fut7 can promote the adhesion and invasion of all cells by activating the integrin/fak/akt pathway.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
FSCN1 Promotes Glycolysis and Epithelial-Mesenchymal Transition in Prostate Cancer through a YAP/TAZ Signaling Pathway

The aim of the study is to investigate the role and possible mechanism of fascin-1 (fscn1) in the invasion, migration, glycolysis, and epithelial-mesenchymal transition (emt) of prostate cancer.Methods.Real-time quantitative polymerase chain reaction (q rt-pcr) was utilized to determine the m rna expression level of fscn1 in prostate cancer tissues and prostate cancer cells pc-3 and du145.The transwell and the scratch test were applied to detect the invasion and migration abilities of cells, respectively.A metabolic assay was used for measuring the glucose consumption, lactate production, and the extracellular acidification rate (ecar) in cells; western blot was used for checking fscn1, emt, and yes-associated protein/transcriptional co-activators with the pdz-binding motif (yap/taz) signaling pathway-related protein expression level in cells or tissues.Results.Fscn1 was significantly highly expressed in prostate cancer tissues and cells.On the one hand, interference with the expression of fscn1 could inhibit the invasion, migration, emt, and glycolysis of prostate cancer cells.On the other hand, overexpression of fscn1 promoted the invasion, migration, emt, and glycolysis of prostate cancer cells.Besides, further mechanistic studies revealed that fscn1 could activate the yap/taz signaling pathway in prostate cancer cells.Conclusion.Fscn1 promotes invasion, migration, emt, and glycolysis in prostate cancer cells by activating the yap/taz signaling pathway.Fscn1 may be used as a biomarker for the diagnosis or treatment in prostate cancer.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Evaluation of the Effectiveness of Artificial Neural Network Based on Correcting Scoliosis and Improving Spinal Health in University Students

In recent years, spinal disorders, spinal deformities, and scoliosis have become more frequent, especially chronic systemic inflammatory diseases, such as early-onset scoliosis, idiopathic scoliosis, and ankylosis spondylitis, which have unknown causes, insidious onset, and progressive development, resulting in irreversible spinal joint deformities and stiffness at advanced stages and high disability rates.As one of the traditional chinese health and fitness qigong exercises, taijiquan has the effect of strengthening the waist and kidneys, sparing the tendons and softening the body, unblocking the meridians, unblocking the qi and blood, and strengthening the body and increasing intelligence.To this end, this paper proposes a data enhancement method that uses the spine line as the control curve to deform the human contours, drawing on the moving least squares deformation method to fit a variety of scoliosis cases and increase the diversity of the dataset, thereby improving the generalisation capability of the network.The colour map and depth map information are then integrated using a four-channel method and a dual feature extraction network structure to improve the accuracy of segmentation.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Evaluation of lncRNA FOXD3-AS1 as a Biomarker for Early-Stage Lung Cancer Diagnosis and Subtype Identification

Lung cancer (lc) is the most commonly diagnosed cancer and the leading cause of cancer-related deaths.More and more long noncoding rna (lnc rna) are associated with cancer.This study aimed to assess whether plasma lnc rna could be used to diagnose early-stage lc and identify subtypes of lc.Methods.For bioinformatic analysis, we used genetic data from the cancer genome atlas, lung adenocarcinoma (luad), and lung squamous cell carcinoma (lusc) datasets and a small cell lung cancer (sclc) dataset from the gene expression omnibus.Real-time quantitative polymerase chain reaction (rt-q pcr) was used to examine the relative expression of lnc rna in lc tissues and plasma samples.The patients’ clinical information was obtained at the time of sample collection.Results.According to public datasets, the lnc rna forkhead box d3 antisense 1 (foxd3-as1) was significantly upregulated in luad, lusc, and sclc tissues over controls.Rt-q pcr assays confirmed this finding in luad, lusc, and sclc tissues and plasma samples.Even early-stage receiver operating characteristic analysis showed that plasma foxd3-as1 could be used to discriminate luad, lusc, and sclc from normal controls and identify lc subtypes sclc.Conclusion.Foxd3-as1 is significantly upregulated in lc tissues and plasma.Foxd3-as1 could be a potential biomarker for lc subtype identification and early diagnosis.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Evaluation Analysis of the Nephrotoxicity of Tripterygium wilfordii Preparations with CONSORT Harms Statement Based on Deep Learning

In this paper, the safety of tripterygium wilfordii polyglycoside (tw) preparation was evaluated by combining literature research and evidence-based evaluation research, so as to provide evidence-based safety information of tripterygium wilfordii polyglycoside preparation (nephroptosis) for government decision making and clinical application.In this paper, we propose a network structure inspired by the lstm gate mechanism.All the research methods of the included references are evaluated by internationally recognized evaluation tools or standards.Prevalence was analyzed according to the type of intervention (e.g., time of administration) and route of administration.The results of this experiment provide methods and suggestions for the evaluation of traditional chinese medicine nephroptosis in the future.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Evaluation Algorithm for Team Strength Based on the Collected Healthcare Data through IoT and Smart Devices

In the past, the fans used to evaluate the strength of the team according to the victory and defeat ranking or according to their own intuition and preferences, however, the strength of the team is difficult to measure in analytical figures.The team’s winning rate is not the only factor to be considered to determine the strength of the team.There are many factors to be considered for determining the strength of the team.According to the variation coefficient of basketball scoring frequency, the paper designs the principal model of basketball players’ pitching target system.The data is captured by io t devices and smart devices.The algorithm sets the number of the frequency of gabor filter transformation features, controls the error accumulation, extracts the cascade features of basketball score video, constructs the video conversion discrimination rules, detects the basketball target, and obtains the tracking target contour to frame information.Finally, it realizes the target tracking detection of the team based on the team strength using an evaluation algorithm.The aim of this research work is to determine the strength of the team based on the healthcare data, team cohesiveness, and variance coefficient of basketball score frequency.The study on the coefficient of variation for basketball score frequency in teams can provide a theoretical research direction for team strength evaluation and meet the real-time needs of the coefficient of variation of basketball score frequency in teams.The empirical results show that the designed algorithm has the optimal execution time, more successful evaluation targets, high efficiency, and more reliability in evaluating the strength of the team.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Erchen Decoction Ameliorates the Metabolic Abnormalities of High-Fat Diet-Fed Rats

Brown adipose tissue (bat) dissipates chemical energy to protect against obesity.In the present study, we aimed to determine the effects of erchen decoction on the lipolysis and thermogenesis function of bat in high-fat diet-fed rats.Methods.Sprague-dawley rats were randomly divided into four groups, which were fed a control diet (c) or a high-fat diet (hf), and the latter was administered with high and low doses of erchen decoction by gavage once a day, for 12 weeks.Body weight, the serum lipid profile, serum glucose, and insulin levels of the rats were evaluated.In addition, the phosphorylation and protein and m rna expression of amp-activated protein kinase (ampk), adipose triglyceride lipase (atgl), peroxisome proliferator-activated receptor γ coactivator- (pgc-) 1α, and uncoupling protein 1 (ucp-1) in bat were measured by immunoblotting and rt-pcr.Results.Erchen decoction administration decreased body weight gain and ameliorated the abnormal lipid profile and insulin resistance index of the high-fat diet-fed rats.In addition, the expression of p-ampk and atgl in the bat was significantly increased by erchen decoction.Erchen decoction also increased the protein and m rna expression of pgc-1α and ucp-1 in bat.Conclusion.Erchen decoction ameliorates the metabolic abnormalities of high-fat diet-fed rats, at least in part via activation of lipolysis and thermogenesis in bat.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Encapsulation of Lactic Acid Bacteria by Lyophilisation with Its Effects on Viability and Adhesion Properties

Lactobacillus (lab) genera are considered important functional food but are found to have a short shelf life.In this study, two lab, lactobacillus plantarum (lp) and lactobacillus rhamnosus (lr), were isolated from sheep’s milk, and whole-genome sequencing was carried out by using 16s r rna illumina nextseq, the netherlands.The lab were encapsulated by the lyophilisation technique using different lyoprotective pharmaceutical excipients.This process was carried out using a freeze dryer (u-tech, star scientific instruments, india).Shelf-life determination was carried out by a 12-month study using the viability survival factor (vsf).The in vitro cell adhesion technique was carried out by using the red snapper fish along with autoaggregation and cell surface hydrophobicity as vital probiotic properties.It was observed that lp has a significantly higher (p &lt; 0.001) vsf of 7.2, while lr has a vsf of 7 (p &lt; 0.05) when both are encapsulated with 10% maltodextrin + 5% sucrose kept at 4°c for 12 months.The result demonstrated that lp had significantly high (p &lt; 0.05) cell adhesion, 96% ± 1.2 autoaggregation, and 6% cell surface hydrophobicity as compared to lr.Moreover, this study demonstrated that lyophilised lab with lyoprotective excipients enhances shelf life without any changes in probiotic properties when kept at 4°c exhibiting all its probiotic properties.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Efficacy of Periodontal Endodontics Combined with Diode Laser (DL) Therapy on Severe Periodontitis

For a long time, the impact of severe periodontitis on the pulp has been the focus of periodontal clinical research.Whether the teeth with severe periodontitis should be treated with pulp has also become the focus of clinical research.Aims.To explore the effect of periodontal endodontic therapy combined with dl therapy on severe periodontitis.Materials and methods.The clinical data of 100 patients with severe periodontitis from january 2020 to july 2022 were selected and included in the retrospective study.According to the different retrieval treatment methods, they were divided into the control group and the treatment group with 50 cases in each group.The control group received periodontal endodontic treatment, and the treatment group received dl treatment on the basis of the control group.The differences in periodontal probing depth (pd), toothache degree, bleeding index (bi), inflammatory factors, plaque index (pli), and attachment loss (al) between the two groups were compared and analyzed.Results.After 3 months of treatment, the bleeding index (bi), plaque index (pli), and periodontal probing depth (pd) of the treatment group were significantly lower than those of the control group, and the difference was statistically significant ( p &lt; 0.05 ).The attachment loss (al) of the group was not significantly different from that of the control group ( p &gt; 0.05 ).Before treatment, there was no significant difference in the levels of inflammatory factors between the two groups ( p &gt; 0.05 ).After 3 months of treatment, the levels of il-6 and crp in the treatment group were significantly lower than those in the control group, and the difference was statistically significant ( p &lt; 0.05 ).Before treatment, there was no significant difference in the levels of inflammatory factors between the two groups ( p &gt; 0.05 ).After 3 days of treatment, the vas score of the treatment group was significantly lower than that of the control group, and the difference was statistically significant ( p &lt; 0.05 ).after treatment, there were no complications during follow-up in the two groups.Conclusion.The application of dl treatment has a significant effect, which can promote the healing of periodontal tissue, reduce the depth of periodontal pockets, and reduce the degree of toothache, thereby providing a reference for clinical treatment.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Efficacy of Ginkgo biloba Extract Combined with Hormones in the Treatment of Sudden Deafness and Its Effect on the Reactivity of Peripheral Blood T Cell Subsets

This work was aimed at exploring the efficacy of ginkgo biloba extract combined with hormones in the treatment of sudden deafness and the influence on the reactivity of peripheral blood t cell subsets (pbtcss).In this work, 64 patients with sudden deafness who were treated in the first affiliated hospital of hunan university of traditional chinese medicine from august 2019 to august 2022 were selected as the research objects.The patients were randomly divided into a hormone group (treatment with prednisone acetate, n = 34 ) and a combination group (treatment with ginkgo-damole combined with prednisone acetate, n = 30 ).After the two groups of patients were treated in different ways, their efficacy, symptom improvement, changes in blood rheology, and pbtcss were compared.The total effective rates (ters) of the hormone group and the combination group were 76.32% and 95.73%, respectively ( p &lt; 0.05 ).The fibrinogen contents of the patients in the combination group were obviously lower than those in the hormone group after 5 d, 7 d, and 10 d of treatment ( p &lt; 0.05 ).The high blood viscosity (hbv) values of patients in the combination group at 5 d, 7 d, and 10 d after treatment were greatly lower than those in the hormone group ( p &lt; 0.05 ).The low blood viscosity (lbv) values after 3 d, 7 d, and 10 d of treatment in the combined group were much lower in contrast to those in the hormone group ( p &lt; 0.05 ).The cd3+, cd4+, and cd4+/cd8+ in peripheral blood in the combination group were sharply higher while the cd8+ in the combined group was lower in contrast to the hormone group ( p &lt; 0.05 ).There was no visible difference in the incidence of adverse reactions between the two groups of patients after treatment ( p &gt; 0.05 ).In conclusion, the combined application of ginkgo biloba extract and hormones could effectively improve the abnormal hemorheological indexes of patients with sudden deafness and effectively relieve the imbalance of pbtcss, which was safe.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Efficacy of Buqi Huoxue Decoction Combined with Cardiac Rehabilitation Nursing after Coronary Intervention in Patients with Acute ST-Segment Elevation Myocardial Infarction and Its Influence on Prognosis

To investigate the efficacy of the application of buqi huoxue decoction combined with cardiac rehabilitation nursing for patients with acute st-segment elevation myocardial infarction (stemi) after percutaneous coronary intervention (pci) and its influence on the prognosis.Methods.120 stemi patients undergoing pci were randomly divided into control group, cardiac care group, traditional chinese medicine and western medicine group (tcm + wm group), and comprehensive treatment group.The control group was treated with a conventional antiplatelet therapy.On the basis of the control group, the cardiac care group was combined with cardiac care treatment.The tcm + wm group was combined with buqi huoxue decoction, and the comprehensive treatment group was combined with cardiac rehabilitation care and buqi huoxue decoction.The total clinical effective rate, readmission rate, and adverse reaction rate of the four groups were measured.Moreover, the myocardial injury markers (creatine kinase isoenzyme (ck-mb), cardiac troponin i (c tn i), and α-hydroxybutyrate dehydrogenase (α-hbdh)), vascular endothelial function indexes (endothelin (et-1) and vascular endothelial growth factor (vegf)), cardiac function indexes (left ventricular ejection fraction (lvef), left ventricle shortening rate (lfs), left ventricular end diastolic diameter (lvedd), and left ventricular end systolic diameter (lvesd)), and qol quality of life score (appetite, spirit, sleep, fatigue, and daily life) were measured.Results.The total effective rate of comprehensive treatment group was obviously increased versus to the control group and cardiac care group.The ck-mb, c tn i, α-hbdh, et-1, lvedd, and lvesd levels and sas and sds scores in the four groups were decreased, and vegf, lvef, and fs levels and qol quality of life scores were increased after treatment.Moreover, the comprehensive treatment group has more significant changes than the other three groups.The readmission rate in comprehensive treatment group was significantly lower than the other three groups, and the difference in the incidence of adverse reactions in the four groups was not statistically significant.Conclusion.Buqi huoxue decoction combined with cardiac rehabilitation after pci has a significant clinical effect on stemi patients with pci postoperative treatment, which can effectively reduce myocardial injury, improve the patient's cardiac function and vascular endothelial function, and improve the patient's quality of life, which can better improve the prognosis of patients.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Clinical Study;
Analysis of Professional Psychological Adaptability of Students Majoring in Hotel Management and Digital Operation for Higher Vocational Education under Deep Learning

Under the background of rapid and comprehensive development of society and technology, the accommodation industry has shown a relatively prosperous development trend, which has promoted the reform and development of the hotel industry.The scale, quantity, and mode of hotel enterprises have undergone great changes, and there has been a structural surplus.Among them, the most obvious change is the integration of digital technology, which integrates technology and hotel services to form a new hotel format.Combined with a series of policy encouragement trends promulgated by the state, the hotel management and digital operation majors in higher vocational education are more targeted for the cultivation of talents, which can cultivate talents with innovative ability and industry skills in the hotel industry.In this context, it is very important to carry out an adaptive analysis on the professional psychology of students majoring in hotel management and digital operations, which can tap their potential and promote the improvement of teaching quality.Aiming at this subject, this work proposes a neural network (ppanet) for analyzing the psychological adaptability of students in this major.Aiming at the problem that cnn cannot capture the periodicity and trend of data, this work proposes a multiscale deep residual network.The network adds convolution kernels with different scales to learn data features and enhances generalization ability and improves accuracy through residual short-circuit structure and deep structure.Furthermore, based on re lu, this work proposes an improved ire lu activation function with better learning properties.The systematic experiment verifies the feasibility of applying ppanet to the analysis of professional psychological adaptability of students majoring in hotel management and digital operations.

Journal: Wireless Communications and Mobile Computing (2022)
Publication types: Research Article;
Efficacy and Safety of Rituximab in the Treatment of Idiopathic Membranous Nephropathy: A Meta-Analysis

Primary membranous nephropathy (mn), sometimes referred to as idiopathic membranous nephropathy (imn), is a kind of mn whose pathogenesis is yet unclear.According to research reports, the incidence of imn is about 9.8–26.8%, and it is on the rise.Methods.The computer retrieves eight databases to obtain controlled trials at home and abroad on the rituximab (rtx) actions in imn management.After a rigorous literature quality evaluation, software called rev man 5.3 was used for data analysis.Results.This meta-analysis finally contained 8 papers.They were all regarded as controlled trials.Six studies reported serum creatinine (standardized mean difference [smd]: −6.87; 95% ci: −14.09, 0.35; p = 0.062 ), alb (smd: 1.91; 95% ci: −0.31, 4.14; p = 0.092 ), and adverse reactions (or: 0.56; 95% ci: 0.36, 0.90; p &lt; 0.01 ), all of which were significantly higher in the test group than in the control group (or: 1.37; 95% ci: 1.07, 1.76; p &lt; 0.01 ) conclusion.The overall effective rate, serum creatinine, adverse effects, and alb of this trial indicate that rtx may be beneficial for individuals with imn, but further high-quality research is required to confirm these findings.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Meta-Analysis;