syedzayyan/paper_mill_benchmark huggingface dataset:
Cross-cultural adaptation and validation of two crisis resource management scales.

Simulation training programs in crisis resource management must be evaluated using valid and reliable instruments.We translated into spanish and linguistically validate the mayo high performance teamwork scale (mhpts) and ottawa crisis resource management global rating scale (ottawa grs) non-technical skills assessment instruments.Method we performed a standardised cross-cultural adaptation process.The psychometric properties of both instruments in their versions adapted to spanish were subsequently evaluated in a sample of 100 students by using exploratory factor analysis and assessing internal consistency and convergent validity through a total of 94 simulation scenarios in urgent medical situations results: our results for the mhpts showed a one-dimensional structure containing 8 items which explained a total variance of 72.84%; the ottawa grs also had a one-dimensional structure, this time with 5 items, which explained a total variance of 91.79%.According to the cronbach alpha, the internal consistency for the mhpts was 0.94 (1-8 items) and 0.98 for the ottawa grs.In addition, there was a strong correlation between the mhpts and ottawa grs (r = 0.97; p < 0.001).Conclusion we found strong evidence for the high validity and reliability of the spanish versions of both these tools when tested in spanish simulated emergency contexts.

Journal: International emergency nursing (2021)
Publication types: Journal Article
VCP relocalization limits mitochondrial activity, GSH depletion and ferroptosis during starvation in PC3 prostate cancer cells.

During periods of crisis, cells must compensate to survive.To this end, cells may need to alter the subcellular localization of crucial proteins.Here, we show that during starvation, vcp, the most abundant soluble atpase, relocalizes and forms aggregate-like structures at perinuclear regions in pc3 prostate cancer cells.This movement is associated with a lowered metabolic state, in which mitochondrial activity and ros production are reduced.Vcp appears to explicitly sense glutamine levels, as removal of glutamine from complete medium triggered vcp relocalization and its addition to starvation media blunted vcp relocalization.Cells cultured in gln(+) starvation media exhibited uniformly distributed vcp in the cytoplasm (free vcp) and underwent ferroptotic cell death, which was associated with a decrease in gsh levels.Moreover, the addition of a vcp inhibitor, cb-5083, in starvation media prevented vcp relocalization and triggered ferroptotic cell death.Likewise, expression of gfp-fused vcp proteins, irrespective of atpase activities, displayed free vcp and triggered cell death during starvation.These results indicate that free vcp is essential for the maintenance of mitochondrial function and that pc3 cells employ a strategy of vcp self-aggregation to suppress mitochondrial activity in order to escape cell death during starvation, a novel vcp-mediated survival mechanism.

Journal: Genes to cells : devoted to molecular & cellular mechanisms (2021)
Publication types: Journal Article
Is the Fistula First Approach still valid?

The fistula first breakthrough initiative, founded in 2003, was responsible for changing the access profile in the united states, increasing the prevalence of arteriovenous fistulas (avfs) by 50% and reducing that of arteriovenous grafts (avgs).However, the concept that avfs are always the best access for all patients has been challenged.Discussion points are: (1) the questionable survival benefit of avfs over avgs, if one takes into account the high rates of primary avf failure; (2) the potential benefits of using avgs for greater primary success; and (3) the questionable benefit of avfs over avgs in patients with shorter survival, such as the elderly.The high rate of primary failure and maturation procedures leads to prolonged use of catheters, and it is one of the weaknesses of the fistula first strategy.Avgs proved to be better than avfs as a second access after the failure of a first avf, and in patients with non-ideal vessels, with greater primary success and reduced catheter times.Avgs appear to have a similar survival to avfs in patients older than 80 years, with less primary failures and interventions to promote maturation.The most recent kdoqui guidelines suggest an individualized approach in access planning, taking into account life expectancy, comorbidities and individual vascular characteristics, with the aim of chosing adequate access for the right patient, at the right time, for the right reasons.

Journal: Jornal brasileiro de nefrologia (2021)
Publication types: Journal Article
CSF Leaks due to Electric Scooter Injury.

There has been a rapid increase in electric motorized scooter (e-scooter) usage after the introduction of dockless, shareable devices.Methods case series from three tertiary hospitals in los angeles between may-september 2019.Results five patients had skull base fractures and csf leaks or pneumocephalus after e-scooter accident, none wore helmets.Two patients were treated with observation alone, two patients were treated with lumbar drain or external ventriculostomy placement, and one patient died of their injuries prior to definitive management.Conclusion without appropriate safety policies in place, the number of such injuries may increase as the use of e-scooters increase.Laryngoscope, 131:e1035-e1037, 2021.

Journal: The Laryngoscope (2021)
Publication types: Case Reports;Journal Article
Superficial siderosis of the central nervous system associated with ventral dural defects: bleeding from the epidural venous plexus.

Superficial siderosis of the central nervous system is a rare intractable disease induced by chronic subarachnoid hemorrhage.Neurological deficits, such as cerebellar ataxia and hearing difficulties, gradually progress if left undiagnosed.Hemosiderin deposition is irreversible because standard medical treatment has not yet been established.Interventions at the source of bleeding may be the key to a preferable outcome of treatment for chronic subarachnoid hemorrhage; however, the source is not clear in many cases.Methods among the consecutive cases diagnosed with a spontaneous cerebrospinal fluid (csf) leak, cases of superficial siderosis associated with a csf leak due to a ventral dural defect were retrospectively analyzed.Results among 77 cases of a csf leak, 7 cases (9%) of superficial siderosis were identified (median age of 59 years, male, 4 cases).Defects were diagnosed on 1-mm sliced fast imaging employing steady-state acquisition mri (n = 5), conventional myelographic ct (n = 1), or dynamic myelographic ct (n = 1) at high thoracic levels (t1-t4).All defects were repaired by direct neurosurgery.During surgery, continuous bleeding from the epidural veins of the internal vertebral venous plexus was identified as the source of subarachnoid hemorrhage.Epidural csf pulsations through the defect prevented clot formation by the epidural veins.Dural repair stopped free communication between the subarachnoid and epidural spaces, leading to the disappearance of chronic subarachnoid hemorrhage.Conclusion bleeding from the epidural venous plexus may be the cause of superficial siderosis associated with ventral dural defects.Neurosurgical repair may stop the progression of this condition.

Journal: Journal of neurology (2021)
Publication types: Journal Article
The Key Role of Hepcidin-25 in Anemia in Multiple Myeloma Patients with Renal Impairment.

And objectives:anemia is common in multiple myeloma (mm) and is caused by a complex pathomechanism, including impaired iron homeostasis.Our aim is to evaluate the biomarkers of iron turnover: serum soluble transferrin receptor (s tf r) and hepcidin-25 in patients at various stages of mm in relation with markers of anemia, iron status, inflammation, renal impairment and burden of the disease and as predictors of mortality.materials and methods:seventy-three mm patients (six with smoldering and 67 with symptomatic disease) were recruited and observed for up to 27 months.Control group included 21 healthy individuals.Serum s tf r and hepcidin were measured with immunoenzymatic assays.results:mm patients with and without anemia had higher s tfr compared to controls, while only anemic patients had higher hepcidin-25.Both hepcidin-25 and s tf r were higher in anemic than non-anemic patients.Higher hepcidin-25 (but not s tf r) was associated with increasing mm advancement (from smoldering to international staging system stage iii disease) and with poor response to mm treatment, which was accompanied by lower blood hemoglobin and increased anisocytosis.Neither serum hepcidin-25 nor s tf r were correlated with markers of renal impairment.Hepcidin-25 predicted blood hemoglobin in mm patients independently of other predictors, including markers of renal impairment, inflammation and mm burden.Moreover, both blood hemoglobin and serum hepcidin-25 were independently associated with patients' 2-year survival.conclusions:our results suggest that hepcidin-25 is involved in anemia in mm and its concentrations are not affected by kidney impairment.Moreover, serum hepcidin-25 may be an early predictor of survival in this disease, independent of hemoglobin concentration.It should be further evaluated whether including hepcidin improves the early diagnosis of anemia in mm.

Journal: Medicina (Kaunas, Lithuania) (2022)
Publication types: Journal Article
Measurement of Agricultural Green Development Level in the Three Provinces of Northeast China Under the Background of Rural Vitalization Strategy.

This paper offers an evaluation index system of agricultural green development level based on the rural vitalization strategy.The evaluation index system includes four dimensions: agricultural development, ecological resource protection, environment-friendly, and industrial extension and integration.Then, the paper calculates the level of agricultural green development in the three provinces of northeast china using the entropy-gray correlation method from 2009 to 2019.The calculation results show that between 2009 and 2019, the level of agricultural green development in the three northeastern provinces of china fluctuates and increases, and there is some variation between them: in terms of the overall level of agricultural green development heilongjiang province > liaoning province > jilin province, in terms of the average change speed of agricultural green development level, heilongjiang province > liaoning province > jilin province; in terms of each dimension, the average level of correlation degree of agricultural development dimension is liaoning province > heilongjiang province > jilin province, the average level of correlation degree of ecological resource protection dimension is heilongjiang province > jilin province > liaoning province, the average level of correlation degree of environment-friendly dimension is heilongjiang province > jilin province > liaoning province, and the average level of correlation degree of industrial extension and integration is liaoning province > heilongjiang province > jilin province.Finally, the basis of the calculation results, combined with the actual situation of agricultural development in the three provinces, the countermeasures, and suggestions for promoting the green development of agriculture are put forward.Specifically, it includes the establishment of an evaluation system for agricultural green development; strengthening the protection of agricultural ecological resources; increasing rural environmental governance; promoting the integrated development of rural tertiary industries; vigorously supporting agricultural scientific and technological innovation; and strengthening regional cooperation and other suggestions.

Journal: Frontiers in public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Association of environmental exposure to perchlorate, nitrate, and thiocyanate with overweight/obesity and central obesity among children and adolescents in the United States of America using data from the National Health and Nutrition Examination Survey (NHANES) 2005-2016.

The association of overweight/obesity, and central obesity with thiocyanate (scn), perchlorate (cio), and nitrate (no) in childhood and adolescence is unclear.Therefore, this study aimed to explore this association in 4447 participants comprising children and adolescents (aged 6-19 years) using data from the united states national health and nutrition examination survey 2005-2016.Scn level was positively associated with overweight/obesity in both children and adolescents, while cio level was negatively associated with overweight/obesity only in children; however, no significant association was found for no level.Similar associations were found between scn level and central obesity.Thus, our results suggest that scn exposure was associated with overweight/obesity and central obesity in both children and adolescents, while a negative association was observed for cio in children.Strategies to monitor the exposure levels and the mechanisms underlying the relationship between exposure and the weight parameters are recommended.

Journal: New directions for child and adolescent development (2022)
Publication types: Journal Article
Propofol Regulates the Expression of BecliN-1 through miR-30b and Protects against Lung Ischemia-Reperfusion Injury.

Pulmonary ischemia-reperfusion can cause severe dysfunction of alveolar epithelium and alveolar cells.Drugs such as propofol have a protective effect on lung ischemia-reperfusion, but this protective mechanism is not stable and requires other factors such as nucleosides.The purpose of this article is to study the protective mechanism of propofol on lung ischemia-reperfusion injury by regulating the expression of becli n-1 by mi r-30b.With 72 male rats as the research object, a rat lung ischemia-reperfusion model was established.Phenol agents were perfused as the perfusion solution to detect the expression levels of mi r-30b and becli n-1, statistical experimental data and analyze the regulatory mechanism of mi r-30b on the expression of becli n-1 and the effect of propofol on the protection of lung ischemia-reperfusion.Research results show that propofol can reduce inflammation, reduce oxidative stress, inhibit lung tissue apoptosis, improve lung function and pathological changes of lung tissue by inhibiting the activation of the jak-stat signaling pathway, and propofol can pass.The protection of mi r-30b's regulation of becli n-1 expression against lung ischemia-reperfusion injury is 30% higher than that of other protective mechanisms.At the same time, the apoptosis rate of inflammatory lung tissue cells is reduced by 13%.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) (2022)
Publication types: Journal Article
Fluorine-Induced Surface Metallization for Ammonia Synthesis under Photoexcitation up to 1550 nm.

The first observation of surface metallization of ti o2-xinduced by fluoride ions is presented.The emerging metallic states are contributed by the 3d orbital of surface ti and the 2p orbital of surface bridging f, which are intrinsically originated from the strong electron repulsion between f-and adjacent ti3+.The metalized ti o2-xwith reduced work function and downward band bending possesses high electron-donating power to supported ru species via atomic-scale ohmic contacts, exhibiting unprecedented photocatalytic performances for ammonia synthesis across the entire solar spectrum region (200-1550 nm) at room temperature.Mechanism and kinetic analysis revealed that the loaded ru could behave as efficient electron sinks to accumulate photogenerated electrons and that the metallic surface markedly enhanced the dissociation of h2and n2by the hot electrons generated by the visible or even infrared light irradiation.

Journal: Angewandte Chemie (International ed. in English) (2021)
Publication types: Journal Article
Attitudes towards influenza, and COVID-19 vaccines during the COVID-19 pandemic among a representative sample of the Jewish Israeli population.

Vaccine hesitancy is increasing.We assessed attitudes toward influenza and covid-19 vaccines and the relation between hesitancy to influenza vaccine and hesitancy towards covid-19 vaccines.Methods a structured questionnaire administered during september 2020 to a representative sample of the jewish israeli population assessed attitudes and acceptance of influenza and covid-19 vaccines.Factors for vaccine hesitancy were determined using logistic regression.Questionnaires were administered prior to the release of clinical data regarding efficacy and safety of covid-19 vaccines and prior to vaccine rollout.Results we approached 10,625 people, of these 2,080 responded (19%), and 2,024 completed the questionnaire (97.3%), 64.9% aged 15-64 years and 35.1% aged ≥65 years.37% had co-morbidities.43.5% experienced financial deterioration due to the pandemic.65.9% received influenza vaccine ≥1 time in the past.Influenza vaccination rates were higher in the elderly (81.8%).Reasons for influenza vaccine hesitancy were opinions that the vaccine is ineffective (27.1%), and fear of side effects (29.3%).8.2% of people aged 16-64 and 13.8% of people aged≥65 refused to be vaccinated at least once over the course of one's lifetime.Percent of responders willing to receive a covid-19 vaccine were higher than percent of responders willing to receive the influenza vaccine both in people aged 16-64 years (942 (72.3%) vs.38.4%, respectively) and in people 65 years and older (84.0% vs.76.8%, respectively).Hesitancy towards covid-19 vaccine was associated with hesitancy towards other vaccines.Only 26.8% would participate in a covid-19 vaccine trial.Conclusions willingness to receive covid-19 vaccine was higher than willingness to receive influenza vaccine.The results point to areas of fear from influenza vaccines side effects and lack of knowledge regarding influenza vaccines effectiveness that can be addressed to increase acceptance.Hesitancy towards other vaccines was associated with hesitancy towards covid-19 vaccination.

Journal: PloS one (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Wildfire effects on two freshwater producers: Combining in-situ and laboratory bioassays.

Mediterranean forests are highly susceptible to wildfires, which can cause several impacts not only within burnt areas but also on downstream aquatic ecosystems.The ashes' washout from burnt areas by surface runoff can be a diffuse source of toxic substances, such as metals, when reaching the nearby aquatic systems, and can be noxious to aquatic organisms.The present work aimed at assessing the ecotoxicological effects of post-fire contamination on two aquatic producers (the microalgae raphidocelis subcapitata and the macrophyte lemna minor) through in-situ bioassays, validating the obtained results with the outcomes of laboratory bioassays with surface water collected simultaneously.Four distinct sites were selected in a basin partially burnt (ceira river basin; coimbra district, portugal) for bioassay deployment: one site upstream the burnt area in the ceira river (rus); three sites located under the influence of the burnt area, one immediately downstream of the burnt area in the ceira river (rds) and the other two in tributary streams within the burnt area (bs1and bs2).The in-situ bioassays lasted for 13 days and began following the first post-fire major rain events.Results showed that the microalgae growth rate was able to distinguish the three sites within and downstream of the burnt area (bs1, bs2, rds) from the site upstream (rus).By contrast, the macrophytes growth rate only allowed to differentiate between the sites within the burnt area (bs1and bs2) and those up- and downstream of the burnt area (rus and rds).The in-situ results for both species were corroborated with the results of the laboratory experiments, supporting the use of laboratory surrogates for a screening assessment of wildfire impacts in aquatic ecosystems.Direct causal relationships between the observed ecotoxicological effects on r.Subcapitata and l.Minor and the physical-chemical parameters of the water samples were difficult to establish, although the results suggest (i) a role of differential major and trace metal load in explaining species growth variation; (ii) interaction between metals and/or between metals and other field parameters are likely to modulate the biological responses to the challenges deriving from wildfire runoff.

Journal: Ecotoxicology and environmental safety (2020)
Publication types: Journal Article
Residential self-selection, perceived built environment and type 2 diabetes incidence: A longitudinal analysis of 36,224 middle to older age adults.

Much of the existing studies on the built environment and type 2 diabetes are cross-sectional and prone to residential self-selection bias.Using multilevel logistic regression analysis of 36,224 participants from a longitudinal study, we examined whether perceived built environment characteristics are associated with type 2 diabetes.We found that the odds of diabetes incidence varied geographically.Those who reported that there were no local amenities and reported day- and night-time crime rates made walking unsafe in the neighbourhood had higher odds of developing incident type 2 diabetes.These associations persisted after accounting for some predictors of residential self-selection.More longitudinal studies are needed to corroborate the findings.Changing the features of the residential built environment may be an important point of intervention for type 2 diabetes prevention.

Journal: Health & place (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Dispositional mindfulness and its relationship to exercise motivation and experience.

Mindfulness is the psychological state of staying attuned to the present moment, without ruminating on past or future events, and allowing thoughts, feelings, or sensations to arise without judgment or attachment.Previous work has shown that heightened dispositional mindfulness is associated with the awareness of the importance of exercise, exercise self-efficacy, exercise motivation, and self-reported exercise level.However, more methodologically rigorous studies are needed to understand the relationship between mindfulness and the psychological mechanisms related to exercise motivation, including the identification of why individuals are motivated to engage in exercise, the subjective experience of exercise, and the propensity for exercise dependence and addiction.In this cross-sectional investigation, we utilized the framework of the self-determination theory to examine the hypothesis that heightened dispositional mindfulness (as measured by the mindful attention awareness scale) would be associated with increased levels of exercise motivation that were derived by higher levels of autonomous self-regulation.Individuals were recruited from urban areas who self-reported either low (exercising 2 or fewer times per week for 20 min or less;n= 78) or moderate (exercising 1 or 2 times per week for 20 min or more;n= 127) levels of exercise engagement.As hypothesized, heightened dispositional mindfulness was significantly associated with heightened levels of exercise self-determination as measured by the behavioral regulations in exercise questionnaire, with this effect being driven by negative associations with amotivation, external regulation, and introjected regulation.Additionally, we found that heightened dispositional mindfulness was associated with lower levels of psychological distress upon exercise and decreased exercise dependence/addiction.Overall, increased dispositional mindfulness may support a healthy relationship with exercise.These findings have implications for the utility of mindfulness interventions to support the regulation of exercise behaviors in service of enhancing exercise motivation and engagement.

Journal: Frontiers in sports and active living (2022)
Publication types: Journal Article