syedzayyan/paper_mill_benchmark huggingface dataset:
Murine Models of Chronic Viral Infections and Associated Cancers.

Viruses are now recognized as bona fide etiologic factors of human cancer.Carcinogenic viruses include epstein- barr virus (ebv), high-risk human papillomaviruses (hpvs), hepatitis b virus (hbv), hepatitis c virus (hcv), human t-cell leukemia virus type 1 (htlv-1), human immunodeficiency virus type 1 (hiv-1, indirectly), and several candidate human cancer viruses.It is estimated that 15% of all human tumors worldwide are caused by viruses.Tumor viruses establish long-term persistent infections in humans, and cancer is an accidental side effect of viral replication strategies.Viruses are usually not complete carcinogens, supporting the concept that cancer results from the accumulation of multiple cooperating events, in which human cancer viruses display different, often opposing roles.The laboratory mouse mus musculusis one of the best in vivo experimental systems for modeling human pathology, including viral infections and cancer.However, mice are unsusceptible to infection with the known carcinogenic viruses.Many murine models were developed to overcome this limitation and to address various aspects of virus-associated carcinogenesis, from tumors resulting from xenografts of human tissues and cells, including cancerous and virus infected, to genetically engineered mice susceptible to viral infections and associated cancer.The review considers the main existing models, analyzes their advantages and drawbacks, describes their applications, outlines the prospects of their further development.

Journal: Molecular biology (2022)
Publication types: Journal Article
Latent classes of posttraumatic stress disorder among survivors of the Bam Earthquake after 17 years.

The purpose of this study was to identify latent classes of the severity of post-traumatic stress disorder (ptsd) among the survivors of the earthquake in bam, south-eastern iran, 17 years after the disaster.The most influential predictor variables of ptsd classes were also investigated.Methods eight hundred survivors of the bam earthquake who were at least four years old in that disaster were selected by multistage sampling.The ptsd checklist-civilian version was used.Latent class analysis was performed to identify subgroups of people with different ptsd symptom profiles.Latent class regression analysis was used to explore the influence of demographic and traumatic variables on each class membership.Results we found three latent classes of ptsd, with the following profiles emerging: low symptom (56.6% of the participants), moderate symptom (23.5%), and severe symptom (19.9%).Old age [or = 2.20, 95% ci = (1.46, 3.32)], physical injury [or = 1.95, 95% ci = (1.24, 3.06)], being trapped under the rubble [or = 1.81, 95% ci = (1.15, 2.86)], and death of a family member [or = 1.86, 95% ci = (1.12, 3.09)] were positive risk factors for ptsd and increased the chance of being in classes having more severe symptoms.Having a high educational level was a negative risk factor [or = 0.86, 95% ci = (0.67, 1.11)].Conclusions the severity of ptsd 17 years after the earthquake shows that natural disasters such as earthquakes have long-term consequences, and earthquake survivors must have psychological support and long term health care.After any catastrophic earthquake, governments should establish psychology and psychotherapy centers for earthquake victims, and these centers should support earthquake victims for a sufficiently long time.

Journal: BMC psychiatry (2022)
Publication types: Journal Article
Xerostomia: prevention with Pycnogenol® supplementation: a pilot study.

The aim of this pilot study was the evaluation of primary, idiopathic mucosal dryness (xerostomia or dry mouth) in subjects without cancer.Methods a group of non-diabetic subjects and a group of diabetics were managed with standard management (sm) or with sm+pycnogenol® (150 mg/day) for 2 weeks.Results in total, 48 subjects were included in the study; 24 diabetics and 24 non-diabetics.12 diabetics and 12 non-diabetics took pycnogenol® and 12 diabetics and 12 non-diabetics were followed up with standard management only and served as controls.No side effects and no tolerability problems were observed with pycnogenol®.The registry groups were comparable for characteristics and symptoms at baseline.All otherwise healthy subjects had a bmi<26 kg/m2.In 2 weeks, salivary flow and oxidative stress improved significantly in both groups of subjects (non-diabetics and diabetics) with 150 mg/day pycnogenol® (p<0.05), while minimal improvements in salivary flow were seen with sm.The subjective score and the number of mucosal breaks and ulcerations, all minimal (<1 mm in length or diameter), were significantly decreased with pycnogenol® supplementation (p<0.05) with minimal variations in the sm controls.Finally, the mean lysozyme level in parotid saliva samples was significantly increased in the pycnogenol® group (p<0.05) both in diabetics and non-diabetics.Conclusions based on these preliminary results, pycnogenol® could be a new, valid option for the treatment of xerostomia.

Journal: Minerva stomatologica (2019)
Publication types: Journal Article
Recurrence rates after endoscopic resection of large colorectal polyps: A systematic review and meta-analysis.

Complete polyp resection is the main goal of endoscopic removal of large colonic polyps.Resection techniques have evolved in recent years and endoscopic submucosal dissection (esd), endoscopic mucosal resection (emr) with margin ablation, cold snare polypectomy (csp), cold emr, and underwater emr have been introduced.Yet, efficacy of these techniques with regard to local recurrence rates (lrrs)vstraditional hot snare polypectomy and standard emr remains unclear.Aim to analyze lrr of large colonic polyps in a systematic review and meta-analysis.Methods medline, embase, ebm reviews, and cinahl were searched for prospective studies reporting lrr or incomplete resection rate (irr) after colonic polypectomy of polyps ≥ 10 mm, published between january 2011 and july 2021.Primary outcome was lrr for polyps ≥ 10 mm.Results six thousand nine hundred and twenty-eight publications were identified, of which 34 prospective studies were included.Lrr for polyps ≥ 10 mm at up to 12 mo' follow-up was 11.0% (95%ci, 7.1%-14.8%; 15 studies; 4904 polyps).Esd (1.7%; 95%ci, 0%-3.4%; 3 studies, 221 polyps) and endoscopic mucosal resection with margin ablation (3.3%; 95%ci, 2.2%-4.5%; 2 studies, 947 polyps) significantly reduced lrrvsstandard emr without (15.2%; 95%ci, 12.5%-18.0%; 4 studies, 650 polyps) or with unsystematic margin ablation (16.5%; 95%ci, 15.2%-17.8%; 6 studies, 3031 polyps).Conclusion lrr is significantly lower after esd or emr with routine margin ablation; thus, these techniques should be considered standard for endoscopic removal of large colorectal polyps.Other techniques, such as csp, cold emr, and underwater emr require further evaluation in prospective studies before their routine implementation in clinical practice can be recommended.

Journal: World journal of gastroenterology (2022)
Publication types: Journal Article;Meta-Analysis;Systematic Review
Public-private partnership in Iranian hospitals: Challenges and opportunities.

Nowadays, various strategies are applied by governments to control costs and finance hospitals and the health sector.Public-private partnership (ppp) option is one of these strategies.Considering the growing importance of hospitals in different communities and their problems, this study aimed to identify ppp challenges, opportunities and solutions in hospitals.This study aimed to identify the challenges and opportunities of ppp in the country's hospitals and then offered an appropriate solution to overcome these challenges.Materials and methods this is a qualitative study and content analysis approach is undertaken.The participants were selected through purposive sampling and data were collected using a semi-structured interview with experts in the public and private health sector until the saturation point achieved.Data analysis was performed through the thematic analysis of expert's statements using maxqda.10 software in this sector.Results according to the study results, 3 main themes (challenges, opportunities, and solutions), 10 sub-themes, and 32 codes were identified in relation to the public and private partnership.4 sub-themes on challenges of ppp, 3 sub-themes on partnership opportunities and 3 sub-themes on challenges solutions were identified.Conclusion the results of this study revealed that given the discussed challenges the most important challenge seems to be not evaluated outsourcings, incorrect usage of participatory models, and inadequate and inappropriate postoutsourcing supervision, however, it appears evaluated outsourcing backed with adequate supervision could solve many current hospitals' problems.

Journal: Journal of education and health promotion (2022)
Publication types: Journal Article
Extremely Precise Blood-Plasma Separation from Whole Blood on a Centrifugal Microfluidic Disk (Lab-on-a-Disk) Using Separator Gel.

Due to the expansion of point-of-care devices, proposing a convenient and efficient method for blood-plasma separation would help with the use of point-of-care devices.Commercial microfluidic chips are only able to separate a limited amount of plasma, and the majority of these chips need an active valve system, which leads to increase manufacturing cost and complexity.In this research study, we designed a centrifugal microfluidic disk with a passive valve for ultra-accurate and efficient blood-plasma separation on a large scale (2-3 m l).The disk contained a separator gel, which, after applying the centrifugal force, separated the plasma and red blood cells.The passive valve worked based on the inertial force and was able to transfer more than 90% of the separated plasma to the next chamber.The results demonstrated that the separated plasma was 99.992% pure.This study compared the efficiency of the disk containing separating gel with the common lab-on-a-disk design for plasma separation.A comparison of the results showed that although the common lab-on-a-disk design could separate almost pure plasma as the disk contained separator gel, it could only transfer 60% of plasma to the next chamber.

Journal: Diagnostics (Basel, Switzerland) (2022)
Publication types: Journal Article
User Experience of the Co-design Research Approach in eHealth: Activity Analysis With the Course-of-Action Framework.

The cocreation of e health solutions with potential users, or co-design, can help make the solution more acceptable.However, the co-design research approach requires substantial investment, and projects are not always fruitful.Researchers have provided guidelines for the co-design approach, but these are either applicable only in specific situations or not supported by empirical data.Ways to optimize the experience of the co-design process from the point of view of the participants are also missing.Scientific literature in the co-design field generally provides an extrinsic description of the experience of participants in co-design projects.Objective we addressed this issue by describing a co-design project and focusing on the participants' experiences looking at what was significant from their point of view.Methods we used a qualitative situated cognitive anthropology approach for this study.Data were collected on a co-design research project that aimed to support the help-seeking process of caregivers of functionally dependent older adults.The methodology was based on the perspective of experience by dewey and used the course-of-action theoretical and methodological framework.Data collection was conducted in 2 phases: observation of participants and recording of sessions and participant self-confrontation interviews using the session recordings.We interviewed 27% (20/74) of the participants.We analyzed the data through nonexclusive emerging categorization of themes using the constant comparative method.Results in total, 5 emerging themes were identified.The perception of extrinsic constraints and the effects of the situation was central and the most important theme, affecting other themes (frustrating interactions with others, learning together, destabilization, and getting personal benefits).Co-occurrences between codes allowed for a visual and narrative understanding of what was significant for the participants during this project.The results highlighted the importance of the role of the research team in preparing and moderating the sessions.They also provided a detailed description of the interactions between participants during the sessions, which is a core aspect of the co-design approach.There were positive and negative aspects of the participants' experiences during this co-design project.Reflecting on our results, we provided potential affordances to shape the experience of participants in co-design.Conclusions potential users are an essential component of the co-design research approach.Researchers and designers should seek to offer these users a positive and contributory experience to encourage participation in further co-design initiatives.Future research should explore how the proposed affordances influence the success of the intervention.

Journal: JMIR human factors (2022)
Publication types: Journal Article
The Way to Modern Shutter Speed Measurement Methods: A Historical Overview.

Exposure time is a fundamental parameter for the photographer when the photo is composed, and the exact length of the exposure may be an essential determinant of performance in certain camera-based applications, e.g., optical camera communication (occ) systems.There can be several reasons to measure the shutter speed of a camera: shutter speed may be checked at the time of manufacturing; it may be necessary to recheck in case of an elder camera model; it may be necessary to be measured if its exact value is not provided by the manufacturer; or a precise measurement may be necessary for a demanding application.In this paper various methods for shutter speed measurement are reviewed, presenting and analyzing methods that are still relevant today either for manufacturers, service personnel, amateur photographers, or the developers of camera-based systems.Each presented method is illustrated by real measurement results and the performance properties of the methods are also presented.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article;Review
Efficiency of Antimicrobial Photodynamic Therapy with Photodithazine®on MSSA and MRSA Strains.

Staphylococccus aureusis a ubiquitous and opportunistic bacteria associated with high mortality rates.Antimicrobial photodynamic therapy (a pdt) is based on the application of a light source and a photosensitizer that can interact with molecular oxygen, forming reactive oxygen species (ros) that result in bacterial inactivation.This study aimed to analyze, in vitro, the action of a pdt with photodithazine®(pdz) in methicillin-sensitive staphylococcus aureus(mssa) and methicillin-resistant staphylococcus aureus(mrsa) strains.The strains were incubated with pdz at 25, 50, 75, and 100 mg/l for 15 min and irradiated with fluences of 25, 50, and 100 j/cm2.The internalization of pdz was evaluated by confocal microscopy, the bacterial growth by counting the number of colony-forming units, as well as the bacterial metabolic activity post-a pdt and the production of ros.In both strains, the photosensitizer was internalized; the production of ros increased when the a pdt was applied; there was a bacterial reduction compared to the control at all the evaluated fluences and concentrations; and, in most parameters, it was obtained complete inactivation with significant difference (p< 0.05).The implementation of a pdt with pdz in clinical strains of s.Aureushas resulted in its complete inactivation, including the mrsa strains.

Journal: Antibiotics (Basel, Switzerland) (2021)
Publication types: Journal Article
Lateral dorsal infundibular approach: an alternative option for the safe completion of difficult laparoscopic cholecystectomy.

Difficult laparoscopic cholecystectomy (lc) due to acute cholecystitis (ac) increases the risk of bile duct injuries and postoperative complications.Here, we added the lateral dorsal infundibular approach as an initial surgical maneuver during lc to improve outcomes.Methods we describe the detailed technical procedure of the lateral dorsal infundibular approach in patients with ac resulting in difficult lc.This technique was developed after nearly 10 years of experience in laparoscopic surgery, and has been routinely used in the past 5 years.We also retrospectively analyzed the perioperative data for 469 patients with difficult lc.Results a total of 469 patients with ac received difficult lc between july 2016 and june 2021, of which 438 (93.4%) performed a lateral dorsal infundibular approach.Sixty-four patients (13.6%) had variations of the hepatic bile duct and cystic duct according to preoperative magnetic resonance cholangiopancreatography, 438 patients (93.4%) received elective surgery, 31 (6.6%) received emergency surgery, and 10 (2.1%) underwent conversion.There was no postoperative bile leaks and no bile duct injuries in the described technique.Conclusion during difficult lc, the critical view of safety can be gradually achieved by changing the surgical approach to achieve cholecystectomy.

Journal: BMC surgery (2022)
Publication types: Journal Article
Abundance of ethnically biased microsatellites in human gene regions.

Microsatellites-a type of short tandem repeat (str)-have been used for decades as putatively neutral markers to study the genetic structure of diverse human populations.However, recent studies have demonstrated that some microsatellites contribute to gene expression, cis heritability, and phenotype.As a corollary, some microsatellites may contribute to differential gene expression and rna/protein structure stability in distinct human populations.To test this hypothesis, we investigate genotype frequencies, functional relevance, and adaptive potential of microsatellites in five super-populations (ethnicities) drawn from the 1000 genomes project.We discover 3,984 ethnically-biased microsatellite loci (ebml); for each ebml at least one ethnicity has genotype frequencies statistically different from the remaining four.South asian, east asian, european, and american ebml show significant overlap; on the contrary, the set of african ebml is mostly unique.We cross-reference the 3,984 ebml with 2,060 previously identified expression strs (e strs); repeats known to affect gene expression (64 total) are over-represented.The most significant pathway enrichments are those associated with the matrisome: a broad collection of genes encoding the extracellular matrix and its associated proteins.At least 14 of the ebml have established links to human disease.Analysis of the 3,984 ebml with respect to known selective sweep regions in the genome shows that allelic variation in some of them is likely associated with adaptive evolution.

Journal: PloS one (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Association of Prediagnostic Blood Metabolomics with Prostate Cancer Defined by ERG or PTEN Molecular Subtypes.

The tmprss2:erggene fusion and ptenloss are two of the most common somatic molecular alterations in prostate cancer.Here, we investigated the association of prediagnostic-circulating metabolomics and prostate cancer defined by erg or pten status to improve understanding of these etiologically distinct molecular prostate cancer subtypes.Methods the study was performed among 277 prostate cancer cases with erg status, 211 with pten status, and 294 controls nested in the health professionals follow-up study (hpfs) and the physicians' health study (phs).We profiled 223 polar and non-polar metabolites using lc-ms in prediagnostic plasma specimens.We applied enrichment analysis and multinomial logistic regression models to identify biological metabolite classes and individual metabolites associated with prostate cancer defined by erg or pten status.Results compared with noncancer controls, sphingomyelin (p: 0.01), ceramide (p: 0.04), and phosphatidylethanolamine (p: 0.03) circulating levels were enriched among erg-positive prostate cancer cases.Sphingomyelins (p: 0.02), ceramides (p: 0.005), and amino acids (p: 0.02) were enriched among tumors exhibiting pten-loss; unsaturated diacylglycerols (p: 0.003) were enriched among pten-intact cases; and unsaturated triacylglycerols were enriched among both pten-loss (p: 0.001) and pten-intact (p: 0.0001) cases.Although several individual metabolites identified in the above categories were nominally associated with erg or pten-defined prostate cancer, none remained significant after accounting for multiple testing.Conclusions the molecular process of prostate carcinogenesis may be distinct for men with different metabolomic profiles.Impact these novel findings provide insights into the metabolic environment for the development of prostate cancer.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
Effects of Acceptance and Commitment Therapy on health-related outcomes for patients with advanced cancer: A systematic review.

Advanced cancer is an incurable and life-threatening disease that poses a major challenge to patients' psychological and physical well-being.Acceptance and commitment therapy is a mindfulness-based behavioural therapy for managing health outcomes and inducing health-related behaviour changes.However, the components and modality of acceptance and commitment therapy and its effectiveness on health outcomes for patients with advanced cancer remain unclear.Objectives this review aimed to identify the main content, delivery mode, dosage and duration of acceptance and commitment therapy, and to systematically summarise evidence regarding its application in patients with advanced cancer for improving physical and psychological outcomes and health-related quality of life.Design systematic review.Data sources pub med, british nursing index, medline, psyc info, embase, cinahl, cochrane central register of controlled trials, china national knowledge infrastructure and wanfang data were searched to identify eligible clinical trials.Review methods two reviewers independently assessed the eligibility of each study and extracted data.The joanna briggs institute critical appraisal checklist was used to evaluate the risk of bias in the included studies.Narrative synthesis was used to present the findings of this review.Results six studies involving 261 participants were included in this review, including five randomised control trials and one with a pretest-posttest design.Two out of the five studies reported acceptance and commitment therapy significantly reduced depressive symptoms and psychological distress post-intervention with a large effect size compared with usual care.One study indicated significant improvements in anxiety, sleep characteristics and health-related quality of life with a large effect size post-intervention.Non-significant changes in fatigue and pain were found.Intervention programmes with no more than four sessions had high adherence rates.Conclusion acceptance and commitment therapy may be a beneficial way to improve depressive symptoms, anxiety, psychological distress, sleep characteristics and health-related quality of life in patients with advanced cancer.However, limited studies, small sample size and methodological heterogeneity weaken the evidence.More rigorous research using brief acceptance and commitment therapy programmes should be conducted within larger samples to further confirm the effectiveness and evaluate its long-term effect on this population.

Journal: International journal of nursing studies (2021)
Publication types: Journal Article;Review;Systematic Review