syedzayyan/paper_mill_benchmark huggingface dataset:
How to effectively promote interprofessional collaboration? - a qualitative study on physicians' and pharmacists' perspectives driven by the theory of planned behavior.

Ajzen's theory of planned behavior (tpb) postulates that individuals' behavioral intention is influenced by their attitudes, subjective norms, and perceived behavioral control.Therefore, it can be used to broaden the understanding of particular behaviors, including healthcare workers' professional activities.Methods in this study, we used tpb as a theoretical framework to evaluate semi-structured interviews with pharmacists and physicians to build an understanding of the interprofessional collaboration between them.Sixteen semi-structured interviews were conducted with pharmacists and eleven with physicians.The sample of participants comprised a diverse group with varying work experience and workplaces.Data were analyzed independently by two researchers following the thematic analysis method using atlas.ti software.Data saturation was set in the absence of new issues arising during the interviews.Results the content analysis allowed for the determination of six main themes: the relationship between previous experiences and attitudes towards collaboration, pharmacist's role in collaboration, mutual reluctance toward collaboration, the role of decision- and policy-makers, knowledge and qualifications gaps regarding collaboration, and lack of organizational paths.Conclusions despite both physicians and pharmacists displaying positive attitudes towards collaboration may foster their intention to establish a professional partnership, subjective norms (e.g., the lack of appropriate legal regulations) and perceived behavioral control (physicians' lack of awareness about pharmacists' qualifications and the low level of interpersonal skills) might impede the process.

Journal: BMC health services research (2021)
Publication types: Journal Article
Both subthalamic and pallidal deep brain stimulation are effective forGNAO1-associated dystonia: three case reports and a literature review.

Mutations in the g-protein subunit alpha o1 (gnao1) gene have recently been shown to be involved in the pathogenesis of early infantile epileptic encephalopathy and movement disorders.The clinical manifestations of gnao1-associated movement disorders are highly heterogeneous.However, the genotype-phenotype correlations in this disease remain unclear, and the treatments for gnao1-associated movement disorders are still limited.Objective the objective of this study was to explore diagnostic and therapeutic strategies for gnao1-associated movement disorders.Methods this study describes the cases of three chinese patients who had shown severe and progressive dystonia in the absence of epilepsy since early childhood.We performed genetic analyses in these patients.Patients 1 and 2 underwent globus pallidus internus (gpi) deep brain stimulation (dbs) implantation, and patient 3 underwent subthalamic nucleus (stn) dbs implantation.In addition, on the basis of a literature review, we summarized and discussed the clinical characteristics and outcomes after dbs surgery for all reported patients with gnao1-associated movement disorders.Results whole-exome sequencing (wes) analysis revealedde novovariants in the gnao1gene for all three patients, including a splice-site variant (c.724-8g > a) in patients 1 and 3 and a novel heterozygous missense variant (c.124g > a; p.Gly42arg) in patient 2.Both gpi and stn dbs were effective in improving the dystonia symptoms of all three patients.Conclusion dbs is effective in ameliorating motor symptoms in patients with gnao1-associated movement disorders, and both stn dbs and gpi dbs should be considered promptly for patients with sustained refractory gnao1-associated dystonia.

Journal: Therapeutic advances in neurological disorders (2022)
Publication types: Journal Article
Severe maternal morbidity in Scotland.

Using a cohort study design, we analysed 17 diagnoses and 9 interventions (including critical care admission) as a composite measure of severe maternal morbidity for pregnancies recorded over 14 years in scotland.There were 762,918 pregnancies, of which 7947 (10 in 1000 pregnancies) recorded 9345 severe maternal morbidity events, 2802 episodes of puerperal sepsis being the most common (30%).Severe maternal morbidity incidence increased from 9 in 1000 pregnancies in 2012 to 17 in 1000 pregnancies in 2018, due in part to puerperal sepsis recording.The odds ratio (95%ci) for severe maternal morbidity was higher for: older women, for instance 1.22 (1.13-1.33) for women aged 35-39 years and 1.44 (1.27-1.63) for women aged > 40 years compared with those aged 25-29 years; obese women, for instance 1.13 (1.06-1.21) for bmi 30-40 kg.m-2and 1.32 (1.15-1.51) for bmi > 40 kg.m-2compared with bmi 18.5-24.9 kg.m-2; multiple pregnancy, 2.39 (2.09-2.74); and previous caesarean delivery, 1.52 (1.40-1.65).The median (iqr [range]) hospital stay was 3 (2-5 [1-8]) days with severe maternal morbidity and 2 (1-3 [1-5]) days without.Forty-one women died during pregnancy or up to 42 days after delivery, representing mortality rates per 100,000 pregnancies of about 365 with severe maternal morbidity and 1.6 without.There were 1449 women admitted to critical care, 807 (58%) for mechanical ventilation or support of at least two organs.We recorded an incidence of severe maternal morbidity higher than previously published, possibly because sepsis was coded inaccurately in our databases.Further research may determine the value of this composite measure of severe maternal morbidity.

Journal: Anaesthesia (2022)
Publication types: Journal Article
Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway.

Cerebral ischemia reperfusion injury (ciri) is still a serious problem threatening human health.Salidroside (sal) is a natural phenylpropanoid glycoside compound with antioxidant, anti-inflammatory, and anti-ischemic properties.This study investigated the protective mechanism of sal on middle cerebral artery occlusion (mcao)- and oxygen-glucose deprivation/reoxygenation (ogd/r) model-induced ciri via regulating the nuclear factor erythroid 2-related factor 2 (nrf2)/thioredoxin 1 (trx1) axis.The results indicated that sal (50 mg/kg or 100 mg/kg, intraperitoneal injection) not only effectively alleviated infarction rate, improved histopathological changes, relieved apoptosis by strengthening the suppression of cleaved caspase-3 and bax/bcl-2 proteins and decreased malondialdehyde (mda) formation, but also increased superoxide dismutase (sod) and catalase (cat) activities and upregulated the expressions of nrf2 and trx1 on mcao-induced ciri rats.Sal also efficiently inhibited apoptosis and decreased oxidative stress in ogd/r-stimulated pc12 cells.Furthermore, blocking the nrf2/trx1 pathway using tretinoin, an nrf2 inhibitor, significantly reversed the protective effect of sal on ogd/r-induced oxidative stress.Moreover, sal reduced the expression of apoptosis signal-regulating kinase-1 (ask1) and mitogen-activated protein kinase (mapk) family proteins.These results demonstrated that sal inhibited oxidative stress through nrf2/trx1 signaling pathway, and subsequently reduced ciri-induced apoptosis by inhibiting ask1/mapk.

Journal: Metabolic brain disease (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Role of microglia autophagy and mitophagy in age-related neurodegenerative diseases.

Microglia, characterized by responding to damage, regulating the secretion of soluble inflammatory mediators, and engulfing specific segments in the central nervous system (cns), function as key immune cells in the cns.Emerging evidence suggests that microglia coordinate the inflammatory responses in cns system and play a pivotal role in the pathogenesis of age-related neurodegenerative diseases (ndds).Remarkably, microglia autophagy participates in the regulation of subcellular substances, which includes the degradation of misfolded proteins and other harmful constituents produced by neurons.Therefore, microglia autophagy regulates neuronal homeostasis maintenance and process of neuroinflammation.In this review, we aimed at highlighting the pivotal role of microglia autophagy in the pathogenesis of age-related ndds.Besides the mechanistic process and the co-interaction between microglia autophagy and different kinds of ndds, we also emphasized potential therapeutic agents and approaches that could be utilized at the onset and progression of these diseases through modulating microglia autophagy, including promising nanomedicines.Our review provides a valuable reference for subsequent studies focusing on treatments of neurodegenerative disorders.The exploration of microglia autophagy and the development of nanomedicines greatly enhances current understanding of ndds.

Journal: Frontiers in aging neuroscience (2022)
Publication types: Journal Article;Review
Deep multi-modal learning for joint linear representation of nonlinear dynamical systems.

Dynamical systems pervasively seen in most real-life applications are complex and behave by following certain evolution rules or dynamical patterns, which are linear, non-linear, or stochastic.The underlying dynamics (or evolution rule) of such complex systems, if found, can be used for understanding the system behavior, and furthermore for system prediction and control.It is common to analyze the system's dynamics through observations in different modality approaches.For instance, to recognize patient deterioration in acute care, it usually relies on monitoring and analyzing vital signs and other observations, such as blood pressure, heart rate, respiration, and electroencephalography.These observations convey the information describing the same target system, but the dynamics is not able to be directly characterized due to high complexity of individual modality and maybe time-delay interactions among modalities.In this work, we suppose that the state behavior of a dynamical system follows an intrinsic dynamics shared among these modalities.We specifically propose a new deep auto-encoder framework using the koopman operator theory to derive the joint linear dynamics for a target system in a space spanned by the intrinsic coordinates.The proposed method aims to reconstruct the original system states by learning the information provided among multiple modalities.Furthermore, with the derived intrinsic dynamics, our method is capable of restoring the missing observations within and across modalities, and used for predicting the future states of the system that follows the same evolution rule.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Minimal Use of Opioids for Pain Relief in an Internal Medicine Department.

S the objective of the study was to determine if pain control was adequate despite our policy of limited opioid use.Methods in this observational cohort study, we reviewed 300 consecutive patient charts from an internal medicine department.We extracted demographic data, as well as the patients' primary diagnosis, pain on admission, daily pain evaluations (numerical rating score [nrs]), and treatment.Significant pain was defined as a score of ≥3 on the nrs.We determined the incidence of pain and pain control and reviewed the charts of those with an nrs ≥3 for ≥3 days to determine the need for opioid therapy.Results of 1692 total hospitalization days in the 300 consecutive patients with a median age of 80 years (1st-3rd quartiles, 65-87 years) there were 204 days with complaints of pain (12.1%) and 149 days (8.8%) with reports of pain of ≥3 on the nrs.Overall, 28.3% (85 of 300) of the patients had significant pain during their hospitalization.Most of the pain, however, (80.0%, 68 of 85) was short-term (1-2 days) whether or not the patient received pain medication.Pain relief treatment in the hospital included opioids in 17 (5.7%, 95% confidence interval [ci] 3.5-8.9) and dipyrone in 36 (12%, 95% ci 8.8-16) of the 300 patients.Pain control was adequate in the seven patients with prolonged pain who did not receive opioids.There were only two patients discharged with prescriptions for opioids (0.7%, 95% ci 0.2-2.6).Conclusions significant pain is common in patients hospitalized in an internal medicine department, but the pain is mostly short term and pain control is adequate despite the restricted use of opioid therapy during hospitalization.

Journal: Southern medical journal (2018)
Publication types: Journal Article;Observational Study
Evolving trends in lung cancer: Epidemiology, diagnosis, and management.

Lung cancer is one of the deadliest cancers globally and accounts for most of the cancer-related deaths in india.Comprehensive data on lung cancer in india are lacking.This review aimed to discuss the epidemiological trends of lung cancers and driver mutations as well as the recent advancements in molecular diagnostics and therapeutic options primarily in non-small cell lung cancer (nsclc) in india.Electronic databases, such as pub med and google scholar, were searched to retrieve the relevant literature published in the past 5 years.As per the globocan 2018 report, lung cancer was ranked the fourth leading cause of cancer (5.9% cases) in india, in all ages and sexes.Furthermore, 63,475 of all cancer-related deaths (8.1%) were attributed to lung cancer (cumulative risk 0.60), making it the third leading cause of cancer-related mortality.The common mutations that have been detected and targeted for treatment in lung cancer patients include egfr, alk, and pd-l1.In india, egfr and alk mutations are commonly reported, but not pd-l1 mutation.Molecular testing has gained importance as several biomarkers are being targeted to diagnose lung cancer patients.Surgery, radiotherapy, systemic chemotherapy, and personalized molecular-targeted therapy prolong the overall survival (os) in patients with nsclc.Although chemotherapy and molecular-targeted therapies have greatly improved the clinical outcomes, prolonged disease control could not be attained in most nsclc patients.In this situation, immunotherapy seems to be potentially beneficial to obtain long-lasting disease control with minimal adverse events or safety concerns.

Journal: Indian journal of cancer (2022)
Publication types: Journal Article;Review
Increased angiogenesis parallels cardiac tissue remodelling in experimental acute Trypanosoma cruzi infection.

Angiogenesis has been implicated in tissue injury in several noninfectious diseases, but its role in chagas disease (cd) physiopathology is unclear.Objectives the present study aimed to investigate the effect of trypanosoma cruzi infection on cardiac angiogenesis during the acute phase of experimental cd.Methods the signalling pathway involved in blood vessel formation and cardiac remodelling was evaluated in swiss webster mice infected with the y strain of t.Cruzi.The levels of molecules involved in the regulation of angiogenesis, such as vascular endothelial growth factor-a (vegf-a), flk-1, phosphorylated extracellular-signal-regulated protein kinase (p erk), hypoxia-inducible factor-1α (hif-1α), cd31, α-smooth muscle actin (α-sma) and also the blood vessel growth were analysed during t.Cruzi infection.Hearts were analysed using conventional histopathology, immunohistochemistry and western blotting.Findings in this study, our data demonstrate that t.Cruzi acute infection in mice induces exacerbated angiogenesis in the heart and parallels cardiac remodelling.In comparison with noninfected controls, the cardiac tissue of t.Cruzi-infected mice presented higher levels of (i) hif-1α, vegf-a, flk-1 and p erk; (ii) angiogenesis; (iii) α-sma+ cells in the tissue; and (iv) collagen -1 deposition around blood vessels and infiltrating throughout the myocardium.Main conclusions we observed cardiac angiogenesis during acute experimental t.Cruzi infection parallels cardiac inflammation and remodelling.

Journal: Memorias do Instituto Oswaldo Cruz (2022)
Publication types: Journal Article
Transferred Photothermal to Photodynamic Therapy Based on the Marriage of Ultrathin Titanium Carbide and Up-Conversion Nanoparticles.

In this research, upconversion nanoparticles (ucnps) are used as a light conversion carrier, and their deep light source penetrability is closely combined with ultrathin two-dimensional (2d) ti3c2txto explore the application efficiency of the complex in phototherapy.Due to the advantages of 2d ti3c2txwith its high absorbance to ultraviolet/visible light, rich atomic defects to load the drugs, and adjustable thinner structure, this 2d material is beneficially applied as the energy donor.Ucnps@ti3c2txwith a photothermal conversion efficiency of 20.7% is proven with the ability to generate reactive oxygen species under a 980 nm laser at the cellular level.Importantly, the main photothermal therapy method can be changed to a photodynamic therapy method due to the degradation of ti3c2txto ti o2under the oxygen-bearing environment.The in vivo experiment was continued to verify that ucnps@ti3c2txcan kill tumor cells and inhibit tumor growth within a certain period.In addition, in vivo treatment with a combination of immunotherapy and phototherapy of ucnps@ ti3c2txis carried out to achieve stronger tumor inhibition over the prolonged time points.

Journal: Langmuir : the ACS journal of surfaces and colloids (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Central neurocytomas: research trends, most cited papers, and scientometrics analysis to date.

Central neurocytoma is the most common primary intraventricular tumor in adults being classified by the world health organization (who) as a benign grade ii tumor with a good prognosis.Given the recent advances with regard to this tumor, a bibliometric analysis was due to study the future direction of research for neurocytomas.A comprehensive elsevier's scopus database search was performed to capture all published and indexed studies to date relevant to neurocytoma.A discrete set of validated bibliometric parameters were extracted and analyzed on r v4.1.3.A total of 1002 documents were included in our analysis covering a period between 1910 and 2021 (111 years).Around 98.5% of the documents were multi-author publications with a collaboration index (ci) of 4.21.Acta neuropathologica, the american journal of surgical pathology, and cancer were the journals to include the highest number of top ten cited articles (2 out of 10 most cited articles, 20%).Switzerland (4 out of 10, 40%) accounted for the country to have the highest number of top 10 most cited articles with the usa (5588 out of 16,395 citations, 34.1%) having the greatest number of citations.Lastly, our analysis reported an annual growth rate of 6.9% for the number of papers produced by year.This is the first bibliometric analysis to study the top 10 most cited articles with regard to neurocytomas.A shift from histopathologic and clinical symptoms towards the treatment and management of the tumor was observed in our analysis.

Journal: Neurosurgical review (2023)
Publication types: Journal Article;Review
Light mediated drug delivery systems: a review.

Achieving a novel drug delivery system needs site-specificity along with dosage control.Many physical, chemical, mechanical, and biological signals are used for developing these systems, out of which light has been used predominantly in the past decade.Light responsive drug delivery systems have tremendous potential, and their exploration is crucial in developing a precise and controlled delivery system.Spatio-temporal and intensity control of light allows better manipulation of drug delivery vehicles than mechanical, chemical, and biological signals.The use of ultraviolet (uv) and near-infrared (nir) light has helped in upgrading therapeutic functionalities, while the use of up-conversion nanoparticles (ucnps) has delivered an extension into theranostic tools.Biomaterials incorporated with photosensitizers can readily respond to changes in light and are vital in achieving clinical successviatranslational research.Further, the inclusion of biological macromolecules for the transportation of drugs, genes, and proteins has seen a broader application of light-controlled systems.The key objective of this review paper is to summarise the evolution of light-activated targeted drug delivery systems and the importance of biomaterials in developing one.

Journal: Journal of drug targeting (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Enhancing Radioiodine Incorporation inBRAF-Mutant, Radioiodine-Refractory Thyroid Cancers with Vemurafenib and the Anti-ErbB3 Monoclonal Antibody CDX-3379: Results of a Pilot Clinical Trial.

Oncogenic activation of mitogen-activated protein kinase (mapk) signaling is associated with radioiodine refractory (rair) thyroid cancer.Preclinical models suggest that activation of the receptor tyrosine kinase erb b-3 (her3) mitigates the mapk pathway inhibition achieved by braf inhibitors in brafv600emutant thyroid cancers.We hypothesized that combined inhibition of braf and her3 using vemurafenib and the human monoclonal antibody cdx-3379, respectively, would potently inhibit mapk activation and restore radioactive iodine (rai) avidity in patients with braf-mutant rair thyroid cancer.methods:patients with brafv600erair thyroid cancer were evaluated by thyrogen-stimulated iodine-124 (124i) positron emission tomography-computed tomography (pet/ct) at baseline and after 5 weeks of treatment with oral vemurafenib 960 mg twice daily alone for 1 week, followed by vemurafenib in combination with 1000 mg of intravenous cdx-3379 every 2 weeks.Patients with adequate124i uptake on the second pet/ct then received therapeutic radioactive iodine (131i) with vemurafenb+cdx-3379.All therapy was discontinued two days later.Treatment response was monitored by serum thyroglobulin measurements and imaging.The primary endpoints were safety and tolerability of vemurafenib+cdx-3379, as well as the proportion of patients after vemurafenb+cdx-3379 therapy with enhanced rai incorporation warranting therapeutic131i.results:seven patients were enrolled; six were evaluable for the primary endpoints.No grade 3 or 4 toxicities related to cdx-3379 were observed.Five patients had increased rai uptake after treatment; in 4 patients this increased uptake warranted therapeutic131i.At 6 months, 2 patients achieved partial response after131i and 2 progression of disease.Next-generation sequencing of 5 patients showed that all had co-occurring telomerase reverse transcriptase promoter alterations.A deleterious mutation in the switch/sucrose non-fermentable (swi/snf) gene arid2was discovered in the patient without enhanced rai avidity after therapy and an rai-resistant tumor from another patient that was sampled off-study.conclusions:the endpoints for success were met, providing preliminary evidence of vemurafenib+cdx-3379 safety and efficacy for enhancing rai uptake.Preclinical data and genomic profiling in this small cohort suggest swi/snfgene mutations should be investigated as potential markers of resistance to redifferentiation strategies.Further evaluation of vemurafenib+cdx-3379 as a redifferentiation therapy in a larger trial is warranted (clinical trials.gov: nct02456701).

Journal: Thyroid : official journal of the American Thyroid Association (2022)
Publication types: Clinical Trial;Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't