syedzayyan/paper_mill_benchmark huggingface dataset:
Functional traits influence patterns in vegetative and reproductive plant phenology - a multi-botanical garden study.

Phenology has emerged as key indicator of the biological impacts of climate change, yet the role of functional traits constraining variation in herbaceous species' phenology has received little attention.Botanical gardens are ideal places in which to investigate large numbers of species growing under common climate conditions.We ask whether interspecific variation in plant phenology is influenced by differences in functional traits.We recorded onset, end, duration and intensity of initial growth, leafing out, leaf senescence, flowering and fruiting for 212 species across five botanical gardens in germany.We measured functional traits, including plant height, absolute and specific leaf area, leaf dry matter content, leaf carbon and nitrogen content and seed mass and accounted for species' relatedness.Closely related species showed greater similarities in timing of phenological events than expected by chance, but species' traits had a high degree of explanatory power, pointing to paramount importance of species' life-history strategies.Taller plants showed later timing of initial growth, and flowered, fruited and underwent leaf senescence later.Large-leaved species had shorter flowering and fruiting durations.Taller, large-leaved species differ in their phenology and are more competitive than smaller, small-leaved species.We assume climate warming will change plant communities' competitive hierarchies with consequences for biodiversity.

Journal: The New phytologist (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The prognostic activity of transforming acidic coiled-coil 3 (TACC3) immunohistochemical expression in colon adenocarcinoma patients.

Introduction colorectal cancer is most common in developed countries.Each year, more than one million people develop colon cancer, and nearly 70,000 people die from the disease.Although medicine has made great strides in the treatment of colorectal cancer, the prognosis of patients is still poor.It is difficult to find the main cause of colon cancer, so it is necessary to introduce new methods that will accurately diagnose the cause of this malignancy.Material and methods paraffin-embedded colon adenocarcinoma samples (n= 97) were assessed immunohistochemically for tacc3 protein.Connections between tacc3 immunoexpression and clinicopathological factors, including the 5-year overall survival (os), were evaluated.Results immunohistochemical expression of tacc3 protein in colon adenocarcinoma samples and non-pathological samples of colon tissue was described as weak, moderate, or strong.As demonstrated, the level of the tacc3 immunohistochemical reactivity was not correlated with demographic factors including gender and age, and clinicopathological factors.The average survival time for all the patients was 36.8 months (95% ci: 33.134-40.536).A multivariate analysis demonstrated that the grade of tumour differentiation (hr = 2.740; 95% ci: 1.864-4.027,p< 0.001) and tacc3 immunoexpression in healthy tissues (hr = 1.700; 95% ci: 1.073-2.694) were independent risk factors for worse survival of patients.Conclusions the high level of tacc3 immunoexpression in cancerous tissue was not associated with malignancy-related clinicopathological factors and 5-year overall survival of patients.

Journal: Przeglad gastroenterologiczny (2022)
Publication types: Journal Article
Photoaffinity labelling strategies for mapping the small molecule-protein interactome.

Nearly all fda approved drugs and bioactive small molecules exert their effects by binding to and modulating proteins.Consequently, understanding how small molecules interact with proteins at an molecular level is a central challenge of modern chemical biology and drug development.Complementary to structure-guided approaches, chemoproteomics has emerged as a method capable of high-throughput identification of proteins covalently bound by small molecules.To profile noncovalent interactions, established chemoproteomic workflows typically incorporate photoreactive moieties into small molecule probes, which enable trapping of small molecule-protein interactions (smpis).This strategy, termed photoaffinity labelling (pal), has been utilized to profile an array of small molecule interactions, including for drugs, lipids, metabolites, and cofactors.Herein we describe the discovery of photocrosslinking chemistries, including a comparison of the strengths and limitations of implementation of each chemotype in chemoproteomic workflows.In addition, we highlight key examples where photoaffinity labelling has enabled target deconvolution and interaction site mapping.

Journal: Organic & biomolecular chemistry (2021)
Publication types: Journal Article;Review
High Remnant Cholesterol Level Potentiates the Development of Hypertension.

Emerging evidence suggests an association between remnant cholesterol (rc) and vascular damage and hypertension.However, this association has not been explored in a large-scale population in china, and a temporal relationship between rc and hypertension also needs to be investigated.Methods we conducted a retrospective cross-sectional study in 2,199,366 individuals and a longitudinal study in 24,252 individuals with repeated measurements of lipid profile and blood pressure in at least a 3-year follow-up.The logistic model was used to explore the association between lipid components and hypertension in the cross-sectional analysis.The cox model was used to analyze the association between high rc (hrc) at baseline and the subsequent incidence of hypertension or the association between hypertension at baseline and incidence of hrc.The cross-lagged panel model was applied to analyze the temporal relationship between rc and hypertension.Results rc level as a continuous variable had the highest correlation with hypertension among lipid profiles, including rc, low-density lipoprotein cholesterol, total cholesterol, non-high-density lipoprotein cholesterol, and triglycerides, with an odds ratio of 1.59 (95% confidence interval: 1.58-1.59).In the longitudinal cohort, hrc at baseline was associated with incident hypertension.We further explored the temporal relationship between rc and hypertension using the cross-lagged analysis, and the results showed that rc increase preceded the development of hypertension, rather than vice versa.Conclusions rc had an unexpected high correlation with the prevalence and incidence of hypertension.Moreover, rc increase might precede the development of hypertension, suggesting the potential role of rc in the development of hypertension.

Journal: Frontiers in endocrinology (2022)
Publication types: Journal Article;Multicenter Study;Research Support, Non-U.S. Gov't
Synthesized 18-Lead Electrocardiogram in Diagnosing Posterior Stemi-Equivalent Acute Coronary Syndrome in Patients with NSTEMI.

To assess the clinical utility of synthesized v7-v9 st-segment elevation (s v7-9 ste) in patients with 12-lead-electrocardiogram (ecg)-based non-ste myocardial infarction (nstemi) in diagnosing left circumflex artery (lcx) stemi-equivalent acute coronary syndrome (acs).Background the 12-lead-ecg is insufficient for diagnosing patients with acs, especially those with an lcx culprit.Methods we retrospectively examined 219 patients with nstemi who underwent synthesized 18-lead ecg acquisition on admission and urgent catheterization.Associations between baseline variables, including s v7-9 ste and lcx stemi-equivalent acs, were analyzed using logistic regression models and receiver operating characteristics.Lcx-culprit acs was defined as thrombolysis in myocardial infarction (timi) 0-1 flow.The association between s v7-9 ste and myocardial damage was also assessed.Results the mean (sd) age of the population was 68.8 (12.0) years, and 81.7% were men.Lcx-culprit nstemi occurred in 58 (26.5%) patients and 15 (6.8%) were lcx stemi-equivalent.Sv7-9 ste was observed in 16 patients (7.9%).Sv7-9 ste was the sole significant predictor of lcx stemi-equivalent acs with an odds ratio of 19.0 (95% ci: 5.6-63.9,p< 0.001), area under the curve of 0.71 (95% ci: 0.58-0.84), sensitivity of 46.7%, and specificity of 95.6%.After adjustment for confounders, s v7-9 ste was significantly associated with a 308% (95% ci: 78-834%) increase in peak high-sensitivity cardiac troponin i (p=0.001).Conclusions sv7-9 ste had sole preprocedural diagnostic utility in detecting lcx stemi-equivalent acs with greater myocardial damage among patients with 12 ecg-based nstemi.The use of synthesized extra leads on admission may help identify patients with nstemi requiring primary revascularization.

Journal: Cardiology research and practice (2022)
Publication types: Journal Article
Auxin Coordinates Achene and Receptacle Development During Fruit Initiation inFragaria vesca.

In strawberries, fruit set is considered as the transition from the quiescent ovary to a rapidly growing fruit.Auxin, which is produced from the fertilized ovule in the achenes, plays a key role in promoting the enlargement of receptacles.However, detailed regulatory mechanisms for fruit set and the mutual regulation between achenes and receptacles are largely unknown.In this study, we found that pollination promoted fruit development (both achene and receptacle), which could be stimulated by exogenous auxin treatment.Interestingly, auxin was highly accumulated in achenes, but not in receptacles, after pollination.Further transcriptome analysis showed that only a small portion of the differentially expressed genes induced by pollination overlapped with those by exogenous auxin treatment.Auxin, but not pollination, was able to activate the expression of growth-related genes, especially in receptacles, which resulted in fast growth.Meanwhile, those genes involved in the pathways of other hormones, such as ga and cytokinin, were also regulated by exogenous auxin treatment, but not pollination.This suggested that pollination was not able to activate auxin responses in receptacles but produced auxin in fertilized achenes, and then auxin might be able to transport or transduce from achenes to receptacles and promote fast fruit growth at the early stage of fruit initiation.Our work revealed a potential coordination between achenes and receptacles during fruit set, and auxin might be a key coordinator.

Journal: Frontiers in plant science (2022)
Publication types: Journal Article
Cyberbullying among Turkish high school students.

Cyberbullying, a new form of the traditional bullying that has been transferred to the electronic environments (social media, online gaming environments, blogs, etc.), from the physical context to the virtual context, refers mainly to aggression that is deliberately carried out by adolescents.This study aims to measure the level of cyberbullying in turkish high school students living in eastern turkey and identify the demographic and socio-economic factors which lead to being bully and being cyberbullied.The study population consists of 470 students aged from 15-19 years.Exploratory factor analysis (efa) and confirmatory factor analysis (cfa) were implemented to identify the factor structure of the scale and it was observed that the turkish version of the cyberbullying scale (cbs) is best represented by a one-factor structure.The comparisons across demographic and socio-economic variables were implemented using independent samples t test, one-way anova, and tukey hsd.To summarize the key findings, the variables that significantly affect the students' cbs scores are; gender, school type, number of siblings, ownership of a mobile phone, length of ownership of a mobile phone, private access to the internet, family supervision, purpose of internet usage, length of time spent on the internet and type of application used to message with others.

Journal: Scandinavian journal of psychology (2021)
Publication types: Journal Article
Ensuring Effective Public Health Communication: Insights and Modeling Efforts From Theories of Behavioral Economics, Heuristics, and Behavioral Analysis for Decision Making Under Risk.

Public health (ph) messaging can have an enormous impact on shaping how individuals within society behave, and can ensure it is in a safe and responsible way, consistent with up-to-date evidence-based ph guidelines.If done effectively, messaging can save lives and improve the health of those within society.However, unfortunately, those within government ph bodies typically have little training about how to effectively represent ph messages in a way that is consistent with psychological theories of cognitive bias, in order to avoid cognitively biasing the public through their messages.As a result of this, inadequate representation of ph messages can result, which can often lead to cognitive bias in those from the public who read or listen to the message information.This can lead to poor decision making of the pubic as a whole, which can then further lead to harm and even death of public members as a result of these poor decisions.One way to minimize the problem of bias in decision making is to explore psychology theories that model how bias can occur from ph messaging, and identify ways in which ph agencies can utilize such approaches to improve the effectiveness of their messages.Previous focus has been largely on behavioral economic theories, however, here, other accounts are offered in addition to these.These include theories of heuristics and theories from the behavior analysis domain, which may increase the predictive power of modeling bias, and have applications for how best to represent ph message information which minimize bias.

Journal: Frontiers in psychology (2021)
Publication types: Journal Article;Review
Phenotype of higher post-load insulin response as a predictor of all-cause mortality and cardiovascular mortality in the Chinese non-diabetic population.

This study aimed to assess whether a higher insulin response increased the long-term risk of mortality in a non-diabetic population.Methods a total of 446 people with normal glucose tolerance (ngt) or impaired glucose tolerance (igt) who participated in the da qing diabetes study, were stratified into quartiles subgroups according to their baseline insulin area under the curve (auc) during oral glucose tolerance test, defined as q1, q2, q3 and q4.The participants were followed from 1986 to 2016 to assess the risk of death in association with the magnitude of post-load insulin response.Results over 30 years, the rates of all cause death were 9.94, 14.81, 15.02, and 17.58 per 1000 person-years across the four groups respectively.The rate for cardiovascular disease (cvd) death was 5.14, 6.50, 6.80 and 10.47 per 1000 person-years.Compared with q1, the risk of all-cause death was significantly higher in participants in q4 (hr = 2.14, 95% ci 1.34-3.42), q3 (hr = 1.94, 95% ci 1.20-3.14), and q2 group (hr = 1.70, 95% ci 1.06-2.74).In the fine-gray model with non-cvd death as competing risk, the increased insulin auc were also significantly associated with the cvd death (q4 vs q1, hr = 2.04, 95% ci 1.10-3.79).In the fractional polynomial regression analysis, a nonlinear association between insulin auc and all-cause and cvd death was demonstrated.In addition, insulin auc was associated with a progressively higher risk of all-cause death and cvd death (fractional power 3, p < 0.001).Conclusion a higher post-load insulin response was significantly associated with a long-term increased risk of all-cause and cvd deaths in the chinese non-diabetic population.It suggests that people featured by this phenotype is a potential important target for further intervention.

Journal: Diabetology & metabolic syndrome (2022)
Publication types: Journal Article
Approaches to incorporate extracellular vesicles into exposure science, toxicology, and public health research.

Extracellular vesicles (evs) represent small, membrane-enclosed particles that are derived from parent cells and are secreted into the extracellular space.Once secreted, evs can then travel and communicate with nearby or distant cells.Due to their inherent stability and biocompatibility, these particles can effectively transfer rnas, proteins, and chemicals/metabolites from parent cells to target cells, impacting cellular and pathological processes.Evs have been shown to respond to disease-causing agents and impact target cells.Given that disease-causing agents span environmental contaminants, pathogens, social stressors, drugs, and other agents, the translation of ev methods into public health is now a critical research gap.This paper reviews approaches to translate evs into exposure science, toxicology, and public health applications, highlighting blood as an example due to its common use within clinical, epidemiological, and toxicological studies.Approaches are reviewed surrounding the isolation and characterization of evs and molecular markers that can be used to inform ev cell-of-origin.Molecular cargo contained within evs are then discussed, including an original analysis of blood ev data from vesiclepedia.Methods to evaluate functional consequences and target tissues of evs are also reviewed.Lastly, the expanded integration of these approaches into future public health applications is discussed, including the use of evs as promising biomarkers of exposure, effect, and disease.Impact statement: extracellular vesicles (evs) represent small, cell-derived structures consisting of molecules that can serve as biomarkers of exposure, effect, and disease.This review lays a novel foundation for integrating evs, a rapidly advancing molecular biological tool, into the field of public health research including epidemiological, toxicological, and clinical investigations.This article represents an important advancement in public health and exposure science as it is among the first to translate evs into this field.

Journal: Journal of exposure science & environmental epidemiology (2022)
Publication types: Journal Article;Review;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Spatial Attention Frustum: A 3D Object Detection Method Focusing on Occluded Objects.

Achieving the accurate perception of occluded objects for autonomous vehicles is a challenging problem.Human vision can always quickly locate important object regions in complex external scenes, while other regions are only roughly analysed or ignored, defined as the visual attention mechanism.However, the perception system of autonomous vehicles cannot know which part of the point cloud is in the region of interest.Therefore, it is meaningful to explore how to use the visual attention mechanism in the perception system of autonomous driving.In this paper, we propose the model of the spatial attention frustum to solve object occlusion in 3d object detection.The spatial attention frustum can suppress unimportant features and allocate limited neural computing resources to critical parts of the scene, thereby providing greater relevance and easier processing for higher-level perceptual reasoning tasks.To ensure that our method maintains good reasoning ability when faced with occluded objects with only a partial structure, we propose a local feature aggregation module to capture more complex local features of the point cloud.Finally, we discuss the projection constraint relationship between the 3d bounding box and the 2d bounding box and propose a joint anchor box projection loss function, which will help to improve the overall performance of our method.The results of the kitti dataset show that our proposed method can effectively improve the detection accuracy of occluded objects.Our method achieves 89.46%, 79.91% and 75.53% detection accuracy in the easy, moderate, and hard difficulty levels of the car category, and achieves a 6.97% performance improvement especially in the hard category with a high degree of occlusion.Our one-stage method does not need to rely on another refining stage, comparable to the accuracy of the two-stage method.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article
A Genetic Variation in the Y Chromosome Among Modern Japanese Males Related to Several Physiological and Psychological Characteristics.

Previous studies in population genetics have proposed that the y-chromosomal (y-dna) haplogroup d ancestor likely originated from africa.The haplogroup d branch next started out-of-africa migration, rapidly expanded across eurasia, and later diversified in east asia.Y-dna haplogroup d-m55, one of the branches of haplogroup d, is only found in modern japanese males, suggesting that individuals with y-dna haplogroup d migrated from the eurasian continent.Based on previous observations, y-dna haplogroup d is expected to be associated with some male characteristics including personality.Therefore, this study investigated whether the y-dna haplogroup d-m55 is associated with several physiological and psychological characteristics, including exploratory motivation and human relationship-related perception.We recruited japanese young adult males and females and investigated the association between y-dna haplogroup d-m55, physiological [body mass index (bmi)], and several psychological parameters [perceived number of close friends, behavioral inhibition system/behavioral activation system (bis/bas), perceived happiness, and perceived loneliness].The results indicated that males with haplogroup d-m55 had a higher bmi and more close friends, compared with non-carrier males.Additional multiple regression analyses, which tested the hypothesis that haplogroup d-m55 predicts bmi and perceived number of close friends, confirmed our hypothesis, even after controlling for the potentially confounding variables of age and sex.We also analyzed the gene-gene interaction between haplogroup d-m55 and an autosomal gene polymorphism associated with bmi and human relationships, such as the dopamine d2 receptor gene (drd2: rs1800497).Results showed gene-gene interactions between haplogroups d-m55 and drd2in bmi.Based on these findings, it is demonstrated that y-dna haplogroup d is associated with human personality.

Journal: Frontiers in behavioral neuroscience (2021)
Publication types: Journal Article
The Impact of Cosmetic Surgery on Women's Marital Satisfaction and Self-Concept.

Today, cosmetic surgery is one of the most common procedures worldwide, and its use is increasing.This study aimed to identify the impact of cosmetic surgery on married women's marital satisfaction and self-concept.Methods from january 1st, 2015 to june 6th, 2015, 44 married women operated in a plastic surgery clinic or seeking for a cosmetic surgery and 55 non-applicants as general population were enrolled.Enrich marital satisfaction questionnaire and rogers' self-concept inventory were used to compare groups.Results operated applicants revealed a significant higher level of satisfaction in comparison with other groups regarding personality, conflict and leisure.Compared to control group, the surgical group had significantly higher satisfaction in marital and familial relationship, friendship, and financial management.Conclusion it can be drawn that expectation for postoperative positive outcome probably is an important factor affecting high level of marital satisfaction in cosmetic surgery applicants.Furthermore, the self-concept is significant predictor of applying for cosmetic surgery.

Journal: World journal of plastic surgery (2018)
Publication types: Journal Article