syedzayyan/paper_mill_benchmark huggingface dataset:
Obesity and Airway Dysanapsis in Children with and without Asthma.

Rationale for unclear reasons, obese children with asthma have higher morbidity and reduced response to inhaled corticosteroids.Objectives to assess whether childhood obesity is associated with airway dysanapsis (an incongruence between the growth of the lungs and the airways) and whether dysanapsis is associated with asthma morbidity.Methods we examined the relationship between obesity and dysanapsis in six cohorts of children with and without asthma, as well as the relationship between dysanapsis and clinical outcomes in children with asthma.Adjusted odds ratios (ors) were calculated for each cohort and in a combined analysis of all cohorts; longitudinal analyses were also performed for cohorts with available data.Hazard ratios (hrs) for clinical outcomes were calculated for children with asthma in the childhood asthma management program.Measurements and main results being overweight or obese was associated with dysanapsis in both the cross-sectional (or, 1.95; 95% confidence interval [ci], 1.62-2.35 [for overweight/obese compared with normal weight children]) and the longitudinal (or, 4.31; 95% ci, 2.99-6.22 [for children who were overweight/obese at all visits compared with normal weight children]) analyses.Dysanapsis was associated with greater lung volumes (fvc, vital capacity, and total lung capacity) and lesser flows (fev1and forced expiratory flow, midexpiratory phase), and with indicators of ventilation inhomogeneity and anisotropic lung and airway growth.Among overweight/obese children with asthma, dysanapsis was associated with severe disease exacerbations (hr, 1.95; 95% ci, 1.38-2.75) and use of systemic steroids (hr, 3.22; 95% ci, 2.02-5.14).Conclusions obesity is associated with airway dysanapsis in children.Dysanapsis is associated with increased morbidity among obese children with asthma and may partly explain their reduced response to inhaled corticosteroids.

Journal: American journal of respiratory and critical care medicine (2017)
Publication types: Journal Article
On the Twentieth Anniversary of Dendritic Cell Vaccines - Riding the Next Wave.

In the mid 1990's, a convergence of discoveries in dendritic cell (dc) biology and tumor antigen identification led investigators to study dcs as adjuvants for cancer vaccines.On the twentieth anniversary of a seminal clinical study by jacques banchereau and colleagues, we revisit the key events that prompted the initial wave of dc vaccine clinical studies and lessons learned that, in our opinion, helped forge the path for the field that we now call immuno-oncology.It is essential to recall that prior to the discovery of immune checkpoint therapy and chimeric antigen receptor (car) t-cell therapy, skepticism prevailed regarding the potential therapeutic benefit of immunotherapies.In hindsight, we can now appreciate how the early dc cancer vaccine trials helped investigators sustain their attention on adaptive immunity specific for malignant cells.These vaccines demonstrated clear evidence for induction of antigen-specific t cells and were well tolerated despite low rates of objective clinical response.In the context of the current era some 20 years later, harnessing dc vaccines has been shown to increase the breadth and diversity of tumor-specific t cells, and by trafficking to sites of metastases promote an inflamed tumor microenvironment.See related article by banchereau and colleagues, cancer res 2001; 61:6451-8.

Journal: Cancer research (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Effect of mobile interventions with nicotine replacement therapy sampling on long-term smoking cessation in community smokers: A pragmatic randomized clinical trial.

Introduction mobile interventions enable personalized behavioral support that could improve smoking cessation (sc) in smokers ready to quit.Scalable interventions, including unmotivated smokers, are needed.We evaluated the effect of personalized behavioral support through mobile interventions plus nicotine replacement therapy sampling (nrt-s) on sc in hong kong community smokers.Methods a total of 664 adult daily cigarette smokers (74.4% male, 51.7% not ready to quit in 30 days) were proactively recruited from smoking hotspots and individually randomized (1:1) to the intervention and control groups (each, n=332).Both groups received brief advice and active referral to sc services.The intervention group received 1-week nrt-s at baseline and 12-week personalized behavioral support through sc advisor-delivered instant messaging (im) and a fully automated chatbot.The control group received regular text messages regarding general health at a similar frequency.Primary outcomes were carbon monoxide-validated smoking abstinence at 6 and 12 months post-treatment initiation.Secondary outcomes included self-reported 7-day point-prevalence and 24-week continuous abstinence, quit attempts, smoking reduction, and sc service use at 6 and 12 months.Results by intention-to-treat, the intervention group did not significantly increase validated abstinence at 6 months (3.9% vs 3.0%, or=1.31; 95% ci: 0.57-3.04) and 12 months (5.4% vs 4.5%, or=1.21; 95% ci: 0.60-2.45), as were self-reported 7-day point-prevalence abstinence, smoking reduction, and sc service use at 6 and 12 months.More participants in the intervention than control group made a quit attempt by 6 months (47.0% vs 38.0%, or=1.45; 95% ci: 1.06-1.97).Intervention engagement rates were low, but engagement in im alone or combined with chatbot showed higher abstinence at 6 months (adjusted odds ratios, aors=4.71 and 8.95, both p<0.05).Conclusions personalized behavioral support through mobile interventions plus nrt-s did not significantly improve abstinence in community smokers compared to text only messaging.The suboptimal intervention engagement needs to be addressed in future studies.Trial registration clinical trials.gov nct04001972.

Journal: Tobacco induced diseases (2023)
Publication types: Journal Article
Development and Characterization of a Luciferase Labeled, Syngeneic Murine Model of Ovarian Cancer.

Despite advances in surgery and targeted therapies, the prognosis for women with high-grade serous ovarian cancer remains poor.Moreover, unlike other cancers, immunotherapy has minimally impacted outcomes in patients with ovarian cancer.Progress in this regard has been hindered by the lack of relevant syngeneic ovarian cancer models to study tumor immunity and evaluate immunotherapies.To address this problem, we developed a luciferase labeled murine model of high-grade serous ovarian cancer, stose.m1 luc.We defined its growth characteristics, immune cell repertoire, and response to anti pd-l1 immunotherapy.As with human ovarian cancer, we demonstrated that this model is poorly sensitive to immune checkpoint modulators.By developing the stose.m1 luc model, it will be possible to probe the mechanisms underlying resistance to immunotherapies and evaluate new therapeutic approaches to treat ovarian cancer.

Journal: Cancers (2022)
Publication types: Journal Article
Downregulation of the Tumor Suppressor TFF1 Is Required during Induction of Colon Cancer Progression by L1.

The immunoglobulin family cell adhesion receptor l1 is induced in crc cells at the invasive front of the tumor tissue, and confers enhanced proliferation, motility, tumorigenesis, and liver metastasis.To identify putative tumor suppressors whose expression is downregulated in l1-expressing crc cells, we blocked the l1-ezrin-nf-κb signaling pathway and searched for genes induced under these conditions.We found that tff1, a protein involved in protecting the mucus epithelial layer of the colon, is downregulated in l1-expressing cells and displays characteristics of a tumor suppressor.Overexpression of tff1 in l1-transfected human crc cells blocks the pro-tumorigenic and metastatic properties conferred by l1 by suppressing nf-κb signaling.Immunohistochemical analyses revealed that human crc tissue samples often lose the expression of tff1, while the normal mucosa displays tff1 in goblet cells.Identifying tff1 as a tumor suppressor in crc cells could provide a novel marker for l1-mediated crc development and a potential target for therapy.

Journal: Cancers (2022)
Publication types: Journal Article
Diarrhea with deficiency kidney-yang syndrome caused by adenine combined withFolium sennawas associated with gut mucosal microbiota.

The present study aims to study and analyze the characteristics of gut mucosal microbiota in diarrhea mice with deficiency kidney-yang syndrome.Ten male mice were randomly divided into the control group and the model group.Diarrhea mice model with deficiency kidney-yang syndrome was established by adenine combined with folium sennae.The kidney structure was observed by hematoxylin-eosin (he) staining.Serum na+-k+-atp-ase and ca2+-mg2+-atp-ase were detected by enzyme-linked immunosorbent assay (elisa).The characteristics of gut mucosal microbiota were analyzed by performing third-generation high-throughput sequencing.The results showed that the model mice exhibit obvious structural damage to the kidney.Serum na+-k+-atp-ase and ca2+-mg2+-atp-ase levels showed a decreased trend in the model group.The diversity and community structure of the gut mucosal microbiota improved in the model group.Dominant bacteria like candidatus arthromitus, muribaculum, and lactobacillus reuterivaried significantly at different taxonomic levels.The characteristic bacteria like bacteroides, erysipelatoclostridium, anaerotignum, akkermansia muciniphila, clostridium cocleatum, bacteroides vulgatus, and bacteroides sartoriiwere enriched in the model group.A correlation analysis described that erysipelatoclostridiumwas positively correlated with na+-k+-atp-ase and ca2+-mg2+-atp-ase levels, while anaerotignumexhibited an opposite trend.Together, adenine combined with folium sennaedamaged the structure of the kidney, affected energy metabolism, and caused disorders of gut mucosal microbiota in mice.bacteroides, erysipelatoclostridium, and anaerotignumshowed significant inhibition or promotion effects on energy metabolism.Besides,akkermansia muciniphila, clostridium cocleatum, bacteroides vulgatus, and bacteroides sartoriimight be the characteristic species of gut mucosal microbiota responsible for causing diarrhea with deficiency kidney-yang syndrome.

Journal: Frontiers in microbiology (2022)
Publication types: Journal Article
Platelet-to-lymphocyte ratio differs between MS and NMOSD at disease onset and predict disability.

We aimed to assess platelet-to-lymphocyte (plr) and neutrophil-to-lymphocyte ratios (nlr) for differentiating multiple sclerosis (ms) from aquaporin-4-antibody-positive neuromyelitis optica spectrum disorders (nmosd) at disease onset.Methods we retrospectively enrolled and reviewed the medical records of patients with ms (n = 50) and nmosd (n = 33) followed in specialized ms/nmosd centers from argentina.Demographical and clinical (manifestation and disability) data and neuroradiological features (new/enlarging or contrast-enhancing lesions) were assessed at baseline, 1 and 2 years.Serum samples were obtained during the first relapse without a previous acute or chronic treatment, at 1 and 2 years.Mixed-effects model was used to identify independent associations between the log-transformed nlr or plr and ms/nmosd outcomes.Results plr is increased in nmosd when compared to ms (229.4 ± 86.74 vs.186.6 ± 70.17, p = 0.01), but no significant differences were found for nlr (3.51 ± 1.29 vs.3.30 ± 1.17, p = 0.43).Plr was the only independent predictor of poor physical disability score (edss ≥ 4) in nmosd patients at 2 years (β=0.28, p = 0.02) after applying multivariate mixed-effects regression analysis.Additionally, multivariate logistic regression analysis showed that the plr was the only independent predictor of edss ≥ 4 at 2 years (or 28.8, p = 0.041) in the nmosd group.The area under the receiver-operating characteristic curve was 0.841.Conclusion plr could be potentially useful as additional diagnostic tool in differentiating these two neuroinflammatory conditions at presentation.Plr can predict severity of neurological disability at 2 years in nmosd patients.

Journal: Multiple sclerosis and related disorders (2022)
Publication types: Journal Article
Ocean surface energy balance allows a constraint on the sensitivity of precipitation to global warming.

Climate models generally predict higher precipitation in a future warmer climate.Whether the precipitation intensification occurred in response to historical warming continues to be a subject of debate.Here, using observations of the ocean surface energy balance as a hydrological constraint, we find that historical warming intensified precipitation at a rate of 0.68 ± 0.51% k-1, which is slightly higher than the multi-model mean calculation for the historical climate (0.38 ± 1.18% k-1).The reduction in ocean surface albedo associated with melting of sea ice is a positive contributor to the precipitation temperature sensitivity.On the other hand, the observed increase in ocean heat storage weakens the historical precipitation.In this surface energy balance framework, the incident shortwave radiation at the ocean surface and the ocean heat storage exert a dominant control on the precipitation temperature sensitivity, explaining 91% of the inter-model spread and the spread across climate scenarios in the intergovernmental panel on climate change fifth assessment report.

Journal: Nature communications (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Bamboo Weaving Inspired Design of a Carbonaceous Electrode with Exceptionally High Volumetric Capacity.

A highly densified electrode material is desirable to achieve large volumetric capacity.However, pores acting as ion transport channels are critical for high utilization of active material.Achieving a balance between high volume density and pore utilization remains a challenge particularly for hollow materials.Herein, capillary force is employed to convert hollow fibers to a bamboo-weaving-like flexible electrode (bwfe), in which the shrinkage of hollow space results in high compactness of the electrode.The volume of the electrode can be decreased by 96% without sacrificing the gravimetric capacity.Importantly, the conductivity of bwfe after thermal treatment can reach up to 50,500 s/m which exceeds that for most other carbon materials.Detailed mechanical analysis reveals that, due to the strong interaction between nanoribbons, young's modulus of the electrode increases by 105 times.After sn o2active materials is impregnated, the bwfe/sn o2electrode exhibits an exceptionally ultrahigh volumetric capacity of 2000 m ah/cm3.

Journal: Nano letters (2022)
Publication types: Journal Article
Microplastics in three typical benthic species from the Arctic: Occurrence, characteristics, sources, and environmental implications.

Microplastics (mps) in the arctic have raised increasing concern, but knowledge on mp contamination in benthic organisms from arctic shelf regions, e.g., the chukchi sea is still limited.Therefore, the present study investigated the occurrence, characteristics, sources, and environmental implications of mps in the three most common benthic species, namely sea anemone (actiniidae und.), deposit-feeding starfish (ctenodiscus crispatus), and snow crab (chionoecetes opilio), from the chukchi sea.The abundances of mps in the three benthic species were significantly greater than those from the bering sea, but lower than those from other regions globally.The top three compositions of mps in the three species were polyester, nylon, and polyethylene terephthalate.The detection limit for mp size in the present study was 0.03 mm and the mean size of mp in the three species was 0.89 ± 0.06 mm.The surfaces of mps found in the starfish and crabs were covered with many attachments, cracks, and hollows, while the surfaces of mps found in the sea anemones were smooth, which was likely a consequence of different feeding behaviors.There was a significantly positive correlation between the abundances of mps and other anthropogenic substances.The mean mp abundances in the sea anemones ranged from 0.2 items/individual to 1.7 items/individual, which was significantly higher than that in the deposit-feeding starfish (0.1-1.4 items/individual) and snow crabs (0.0-0.6 items/individual).Sea anemones inhabiting lower latitudes ingested relatively higher levels of mps than those inhabiting higher latitudes.The mp abundances in the sea anemones are significantly and positively correlated with the seasonal reduced ratio of sea ice coverage from august to september.Our findings indicate that sea anemones could function as a bioindicator of mp pollution, and that the mps in the benthos from the chukchi sea might originate from the melting sea ice, fishery activities and ocean currents.

Journal: Environmental research (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Hydrated electrons mediated in-situ construction of cubic phase CdS/Cd thin layer on a millimeter-scale support for photocatalytic hydrogen evolution.

In this study, non-noble metal cd decorated cubic phase cd s (cd s/cd) thin layer on a millimeter-scale chitosan-mg(oh)2xerogel beads (cmb) were elaborately designed and successfully synthesized via facile hydrated electrons (eaq•-) assistant strategy.The in-situ formation of metallic cd was driven by eaq•-generated from uv/na2so3process.Owing to metallic cd, cmb@cd s/cd exhibited better visible-light absorption ability and more efficient separation capability for photo-induced carriers, its hydrogen production efficiency was about threefold improved compared to cmb@cd s.Both characterization methods and density functional theory calculations determined a built-in electric field from metallic cd to cd s and ohmic-contact between cd and cd s, which largely promoted the carriers transfer efficiency.Moreover, the introduction of metallic cd on the cd s could reduce the δgh*, thus greatly boosting the photocatalytic hydrogen production efficiency.This work provides a simple and green approach to construct metallic cd coupled semiconductor to achieve efficient photocatalytic applications.

Journal: Journal of colloid and interface science (2022)
Publication types: Journal Article
Investigation of factors associated with static and dynamic balance in early-stage lung cancer survivors.

Balance impairment and falls are common among patients after cancer treatment.This study aimed to compare static and dynamic balance functions in lung cancer survivors (lcs) and healthy controls and to investigate the factors related to balance in lcs.Methods cross-sectional data were collected from lung cancer patients whose treatment had been completed within the previous 3 months (n = 60) and age and gender-matched healthy controls (n = 60).Clinical characteristics and history of falls were recorded.Pulmonary function tests and measurements of respiratory muscle strength were performed.Dynamic and static balance, fear of falling, knee-extension strength, physical activity level, dyspnea, comorbidity, and quality of life (qo l) were assessed using the time up and go test, single leg standing test, the fall efficacy scale-international, hand-held dynamometer, the international physical activity questionnaire, the modified medical research dyspnea scale, the charlson comorbidity index, and the european organization for research and treatment of cancer qo l scale.Results lcs reported a higher fall rate and exhibited lower dynamic balance compared to controls (p < 0.05).The number of chemotherapy cycles, number of falls in the past year, fear of falling, perceived dyspnea, forced expiratory volume in 1 s (%), maximal inspiratory pressure (%), knee-extension strength, physical activity score, and qo l score related to physical function were correlated with balance function in lcs (p < 0.05).Conclusion lcs had a higher risk of falls and lower dynamic balance function which might be related to various clinical and physical parameters.Implications for cancer survivors identifying factors related to balance should be considered within the scope of fall prevention approaches for these patients.

Journal: Journal of cancer survivorship : research and practice (2023)
Publication types: Journal Article
Generalized heterophily graph data augmentation for node classification.

Graph data augmentations have demonstrated remarkable performance on homophilic graph neural networks (gnns).Nevertheless, when transferred to a heterophilic graph, these augmentations are less effective for gnn models and lead to reduced performance.To address this issue, we propose a unified augmentation approach called ge pho, a regularization technique for heterophilic graph neural networks based on self-supervised learning, leveraging graph data augmentation to acquire extra information to guide model learning.Specifically, we propose to generate a pseudo-homophily graph that is type-agnostic, enabling us to apply ge pho to both homophilic and heterophilic graphs.Then, we regularize the neighbors with a sharpening technique for data augmentation and generate the auxiliary pseudo-labels to classify the original gnn's output, whose operations are to constrain the local and global node representation, respectively.Extensive experiments on three homophilic graph and six heterophilic graph datasets demonstrate the competitive effectiveness of ge pho in node classification task, and the ablation experiments verify the efficacy of our ge pho in graph data augmentation.

Journal: Neural networks : the official journal of the International Neural Network Society (2023)
Publication types: Journal Article
Diffuse Alveolar Hemorrhage: An Unexpected Effect After Taking Acetylsalicylic Acid.

Diffuse alveolar hemorrhage (dah) is a rare, acute, and life-threatening condition that in most cases is associated with pulmonary-renal syndromes, connective tissue disorders, infections, and drugs.We report a case of a 45-year-old male who developed a diffuse pulmonary hemorrhage after taking 500 mg of acetylsalicylic acid for a month in the context of acute lower back pain.The prolonged use of this acetylsalicylic acid dose led to an increased risk of bleeding.This report describes a rare bleeding site that clinicians should be aware of when managing patients who were exposed to prolonged high dose acetylsalicylic acid.

Journal: Cureus (2022)
Publication types: Case Reports;Journal Article