syedzayyan/paper_mill_benchmark huggingface dataset:
Ageing workers' mental health during COVID-19: a multilevel observational study on the association with the work environment, perceived workplace safety and individual factors.

S the stress and anxiety associated with the predisposition of ageing workers to severe covid-19 illness, once occupationally infected, jeopardise their mental health.This study aimed to investigate the association between individual level, work environment exposure factors and perceived workplace safety with a decline in mental health of ageing workers from different industry sectors.Design observational study, prevalence assessment of survey added to longitudinal cohort data.Setting the survey of health, ageing and retirement in europe (share) from 27 countries in europe and israel participating in the covid-19 survey (summer 2020) and having prepandemic waves' share data.Participants workers aged 50-70 (n=6449) who attended their workplaces at least partially after the pandemic broke out.Primary outcome measure perceived decline in mental health compared with preoutbreak status.Results multilevel analyses demonstrated that 24.5% (95% ci 23.5% to 25.5%) of ageing workers in europe experienced mental health decline associated with national-level self-reported covid-19 burden.Workplace safety perception was the strongest predictor, as each one-point increase in unsafe perception was associated with 60% of mental health decline (or=1.6, 95% ci 1.47 to 1.74), explaining 30% of increased reported mental health symptoms of ageing workers.Safety perception mediates the mental health outcomes of the work environment, such as workplace contagion risk and work location.Female gender (or=1.77, 95% ci 1.55 to 2.02), financial difficulties (or=1.19, 95% ci 1.1 to 1.28), higher vulnerability index (comorbidities, age >60) (or=1.11, 95% ci 1.05 to 1.18), pre-existing mental problems (or=1.78, 95% ci 1.55 to 2.04) and increased national burden of covid-19 (or=1.01, 95% ci 1.0 to 1.02) were associated with declines in mental health, whereas exclusively working on-site was protective.Conclusion vulnerable subgroups for mental health declines among ageing workers were revealed, which warrant their screening and employers' evaluation of workplace conditions of ageing workers to prevent mental health-related implications.Workplace interventions should aim to reduce work environment influences on infection risk and mental distress.

Journal: BMJ open (2022)
Publication types: Observational Study;Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Parafoveal processing of underlying phonological information during Korean sentence reading.

The question of whether phonological information is integrated through the parafovea has remained unanswered particularly in korean sentence reading.The current study used homophones with identical underlying phonological forms but with different orthography to examine phonological preview benefit effects in korean.In an eye-tracking experiment using the boundary paradigm, target fixations were shorter (a) when the preview-target pairs were identical than when they were unrelated, (b) when the pairs were orthographically similar than when they were unrelated, and most importantly, (c) when the pairs were phonologically identical than when they were phonologically similar but different.These results indicate that underlying phonological information of a word, aside from orthographic information, is integrated through parafoveal preview during korean sentence reading.

Journal: Attention, perception & psychophysics (2022)
Publication types: Journal Article
A Longitudinal Investigation of Resilience as a Protective Factor During the COVID-19 Pandemic.

Covid-19 is a global stressor that has been shown to impact mental health outcomes.Given that covid-19 is a unique stressor that has been shown to have mental health consequences, identifying protective factors is imperative.The protective influences of resilience are demonstrated through the extant literature, though less is known about resilience and covid-19 impact.The current study seeks to expand the existing literature on resilience, and on mental health outcomes influenced by covid-19, by longitudinally investigating relative resilience as a buffer against posttraumatic stress disorder (ptsd) symptoms and alcohol consumption, in the wake of a global pandemic.Participants included 549 undergraduates with a history of lifetime trauma exposure.Using a longitudinal path model, we tested the interaction between relative resilience (i.e., an individual's deviation from distress levels predicted by prior trauma exposure relative to other individuals in the same cohort) and covid-19 impact domains (i.e., social media use, worry, exposure, change in substance use, and housing/food insecurity) on ptsd symptoms and alcohol consumption.Findings demonstrate a significant interaction between the covid-19 worry impact domain and baseline resilience on later ptsd symptoms, whereby covid-19 worry impacts ptsd symptoms at low levels of resilience (β = .26,p< .001), marginally impacts ptsd symptoms at mean levels of resilience (β = .09,p= .05), and does not impact ptsd symptoms at high levels of resilience (β = -.08,p= .16).There were no significant main effects nor interaction effects of resilience on alcohol consumption.This article adds to the literature on resilience and covid-19 through examining both internalizing (i.e., ptsd) and substance use outcomes, using longitudinal data, and using a quantitative measure of resilience.

Journal: Traumatology (2022)
Publication types: Journal Article
Spaceflight-Associated Vascular Remodeling and Gene Expression in Mouse Calvaria.

Astronauts suffer from a loss of bone mass at a rate of 1.5% per month from lower regions of the body during the course of long-duration (>30 days) spaceflight, a phenomenon that poses important risks for returning crew.Conversely, a gain in bone mass may occur in non-load bearing regions of the body as related to microgravity-induced cephalad fluid shift.Representing non-load bearing regions with mouse calvaria and leveraging the sts-131 (15-day) and bion-m1 (30-day) flights, we examined spatial and temporal calvarial vascular remodeling and gene expression related to microgravity exposure compared between spaceflight (sf) and ground control (gc) cohorts.We examined parasagittal capillary numbers and structures in calvaria from 16 to 23 week-old c57bl/6 female mice (gc, n = 4; sf, n = 5) from sts-131 and 19-20 week-old c57bl/6 male mice (gc, n = 6; sf, n = 6) from bion-m1 using a robust isolectin-ib4 vessel marker.We found that the vessel diameter reduces significantly in mice exposed to 15 days of spaceflight relative to control.Capillarization increases by 30% (sf vs.Gc,p= 0.054) in sf mice compared to gc mice.The vessel numbers and diameter remain unchanged in bion-m1 mice calvarial section.We next analyzed the parietal pro-angiogenic (vegfa) and pro-osteogenic gene (bmp-2, dmp1, runx2and ocn) expression in bion-m1 mice using quantitative rt-pcr.vegfagene expression increased 15-fold while bmp-2gene expression increased 11-fold in flight mice compared to gc.The linkage between vascular morphology and gene expression in the sf conditions suggests that angiogenesis may be important in the regulation of pathological bone growth in non-weight bearing regions of the body.Short-duration microgravity-mediated bone restructuring has implications in planning effective countermeasures for long-duration flights and extraterrestrial human habitation.

Journal: Frontiers in physiology (2022)
Publication types: Journal Article
GLP-1RAs for Ischemic Stroke Prevention in Patients With Type 2 Diabetes Without Established Atherosclerotic Cardiovascular Disease.

We assessed the effect of glucagon-like peptide 1 receptor agonists (glp-1ras) on ischemic stroke prevention in the asian population with type 2 diabetes (t2d) without established cardiovascular disease.Research design and methods this retrospective cohort study examined data obtained from the taiwan national health insurance research database for the period from 1998 to 2018.The follow-up ended upon the occurrence of hospitalization for ischemic stroke.The median follow-up period was 3 years.The effect of glp-1ra exposure time on the development of hospitalization for ischemic stroke was assessed.Results the glp-1ra and non-glp-1ra user groups both included 6,534 patients.Approximately 53% of the patients were women, and the mean age was 49 ± 12 years.The overall risk of ischemic stroke hospitalization for glp-1ra users was not significantly lower than that for glp-1ra nonusers (adjusted hazard ratio [hr] 0.69 [95% ci 0.47-1.00]; p = 0.0506), but glp-1ra users with a >251-day supply during the study period had a significantly lower risk of ischemic stroke hospitalization than glp-1ra nonusers (adjusted hr 0.28 [95% ci 0.11-0.71]).Higher cumulative dose of glp-1 ras (>1,784 mg) was associated with significantly lower risk of ischemic stroke hospitalization.The subgroup analyses defined by various baseline features did not reveal significant differences in the observed effect of glp-1ras.Conclusions longer use and higher dose of glp-1 ras were associated with a decreased risk of hospitalization for ischemic stroke among asian patients with t2d who did not have established atherosclerotic cardiovascular diseases, but who did have dyslipidemia or hypertension.

Journal: Diabetes care (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Dual adaptive learning multi-task multi-view for graph network representation learning.

Graph network analysis, which achieves widely application, is to explore and mine the graph structure data.However, existing graph network analysis methods with graph representation learning technique ignore the correlation between multiple graph network analysis tasks, and they need massive repeated calculation to obtain each graph network analysis results.Or they cannot adaptively balance the relative importance of multiple graph network analysis tasks, that lead to weak model fitting.Besides, most of existing methods ignore multiplex views semantic information and global graph information, which fail to learn robust node embeddings resulting in unsatisfied graph analysis results.To solve these issues, we propose a multi-task multi-view adaptive graph network representation learning model, called m2agl.The highlights of m2agl are as follows: (1) graph convolutional network with the linear combination of the adjacency matrix and ppmi (positive point-wise mutual information) matrix is utilized as encoder to extract the local and global intra-view graph feature information of the multiplex graph network.Each intra-view graph information of the multiplex graph network can adaptively learn the parameters of graph encoder.(2) we use regularization to capture the interaction information among different graph views, and the importance of different graph views are learned by view attention mechanism for further inter-view graph network fusion.(3) the model is trained oriented by multiple graph network analysis tasks.The relative importance of multiple graph network analysis tasks are adjusted adaptively with the homoscedastic uncertainty.The regularization can be considered as an auxiliary task to further boost the performance.Experiments on real-worlds attributed multiplex graph networks demonstrate the effectiveness of m2agl in comparison with other competing approaches.

Journal: Neural networks : the official journal of the International Neural Network Society (2023)
Publication types: Journal Article
Lessons Learned from the Introduction of Laparoscopic Pancreaticoduodenectomy.

Introduction:minimally invasive techniques have been suggested to achieve enhanced recovery and improved outcome after pancreaticoduodenectomy (pd).This study describes our experience and a stepwise technical implementation of the laparoscopic pancreaticoduodenectomy (lpd) during early introduction in 2016.methods:a team of three hepatopancreaticobiliary surgeons with extensive experience in open pancreaticoduodenectomy (opd) and with advanced laparoscopic skills started a proctor-guided program with lpd.The first 20 carefully selected cases were prospectively reviewed and compared with a matched opd cohort.results:in 20 months, 20 minimally invasive pds were performed.Reviewing the first 10 lpd cases, 7 patients (70%) had anastomosis-related complications, versus 16% in opd (p= .001).After consulting an international lpd expert, the team switched to a hybrid technique consisting of lpd followed by open reconstruction through midline minilaparotomy (lpd-or).In the following 10 cases of lpd-or, no anastomosis-related complications did occur (p= .342 opd versus lpd-or).conclusion:safe introduction of new techniques in minimally invasive major abdominal surgery is imperative.Based on our single-center experience, lpd-or may be safer in the earliest phase of the learning curve of minimally invasive pd, as part of a stepwise implementation toward the fully laparoscopic technique.

Journal: Journal of laparoendoscopic & advanced surgical techniques. Part A (2020)
Publication types: Comparative Study;Journal Article
Effective factors of peroral endoscopic myotomy for treatment of achalasia.

Introduction achalasia (ac) is an esophageal motility disorder clinically manifested as dysphagia.Aim to investigate the effective factors of peroral endoscopic myotomy (poem) for ac treatment.Material and methods a total of 182 ac patients treated between august 2019 and september 2020 were enrolled to receive poem.They were assigned to an effective group (n = 143) and an ineffective group (n = 39).Their clinical data were recorded.The biochemical indices were determined.Results compared with the ineffective group, the eckardt score and incidence of reflux 1 year after the operation were lower in the effective group, and the effective rate 6 months and 1 year after the operation was higher (p < 0.05).Significant differences were observed in drinking history, eckardt score 1 year after the operation, hemoglobin (hb), alanine aminotransferease (alt), white blood cells (wbc), interleukin-6 (il-6) and high sensitivity c-reactive protein (hs-crp) between the two groups (p < 0.05).The eckardt score 1 year after the operation, wbc, il-6 and hs-crp were lower, while the levels of hb and alt were higher in the effective group than those in the ineffective group.Multivariate logistic analysis revealed that drinking history, eckardt score at 1 year after the operation, hb, alt, wbc, il-6, and hs-crp were independent factors affecting the therapeutic effect of poem on ac.The results were well fitted by evaluation discrimination and calibration of the nomogram model, with good consistency.Conclusions poem is safe, feasible and effective for ac treatment, based on factors such as drinking history, eckardt score 1 year after the operation, hb, alt, wbc, il-6, and hs-crp.

Journal: Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques (2022)
Publication types: Journal Article
Independent factors FOR poor prognosis in young patients with stage I-III breast cancer.

Breast cancer is the most common malignancy in the population of women under 40 years of age.Young age is an independent factor for poor prognosis.In this research, we tried to establish other factors for poor prognosis in stage i-iii breast cancer.The following parameters were observed: tumor size, lymph node status, histologic grade, hormonal receptor status, ki-67 prognostic index, her2 neu status, histologic type of the tumor, local recurrence and metastases.Logistic regression was used to evaluate the effect of specific factors on the probability of lethal outcome and development of distant metastases.Our patients showed a predominance of t1 tumor (49.4%), had positive lymph nodes (62%) and most of them were p n1 (61.2%).Up to one-third of patients had triple negative status.Ki-67 proliferation index was high (25%).Multicentric tumor was detected in 23% of patients.There was no difference in overall survival between the two types of surgical procedures.Patients with p n0 status had better overall survival.Breast cancer in the population of young women has a more aggressive nature.Study results indicated positive lymph node status as an independent factor for poor prognosis of stage i-iii breast cancer.

Journal: Acta clinica Croatica (2020)
Publication types: Journal Article
Correction to: Tracing Rhizophagus irregularis isolate IR27 in Ziziphus mauritiana roots under field conditions.

The authors of the above-mentioned published article inadvertently omitted dirk redecker, dioumacor fall and diaminatou sanogo from the list of authors.The names and their affiliations presented in this paper.

Journal: Mycorrhiza (2020)
Publication types: Journal Article;Published Erratum
Fourth-generation glucose sensors composed of copper nanostructures for diabetes management: A critical review.

More than five decades have been invested in understanding glucose biosensors.Yet, this immensely versatile field has continued to gain attention from the scientific world to better understand and diagnose diabetes.However, such extensive work done to improve glucose sensing devices has still not yielded desirable results.Drawbacks like the necessity of the invasive finger-pricking step and the lack of optimization of diagnostic interventions still need to be considered to improve the testing process of diabetic patients.To upgrade the glucose-sensing devices and reduce the number of intermediary steps during glucose measurement, fourth-generation glucose sensors (fggs) have been introduced.These sensors, made using robust electrocatalytic copper nanostructures, improve diagnostic efficiency and cost-effectiveness.This review aims to present the essential scientific progress in copper nanostructure-based fggs in the past 10 years (2010 to present).After a short introduction, we presented the working principles of these sensors.We then highlighted the importance of copper nanostructures as advanced electrode materials to develop reliable real-time fggs.Finally, we cover the advantages, shortcomings, and prospects for developing highly sensitive, stable, and specific fggs.

Journal: Bioengineering & translational medicine (2022)
Publication types: Journal Article;Review
Similar Frequency and Inducibility of Intact Human Immunodeficiency Virus-1 Proviruses in Blood and Lymph Nodes.

The human immunodeficiency virus (hiv)-1 latent reservoir (lr) in resting cd4+ t cells is a barrier to cure.Lr measurements are commonly performed on blood samples and therefore may miss latently infected cells residing in tissues, including lymph nodes.Methods we determined the frequency of intact hiv-1 proviruses and proviral inducibility in matched peripheral blood (pb) and lymph node (ln) samples from 10 hiv-1-infected patients on antiretroviral therapy (art) using the intact proviral dna assay and a novel quantitative viral induction assay.Prominent viral sequences from induced viral rna were characterized using a next-generation sequencing assay.Results the frequencies of cd4+ t cells with intact proviruses were not significantly different in pb versus ln (61/106 vs 104/106 cd4+ cells), and they were substantially lower than frequencies of cd4+ t cells with defective proviruses.The frequencies of cd4+ t cells induced to produce high levels of viral rna were not significantly different in pb versus ln (4.3/106 vs 7.9/106), but they were 14-fold lower than the frequencies of cells with intact proviruses.Sequencing of hiv-1 rna from induced proviruses revealed comparable sequences in paired pb and ln samples.Conclusions these results further support the use of pb as an appropriate proxy for the hiv-1 lr in secondary lymphoid organs.

Journal: The Journal of infectious diseases (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Second Victims in Intensive Care-Emotional Stress and Traumatization of Intensive Care Nurses in Western Austria after Adverse Events during the Treatment of Patients.

The second victim phenomenon is common among nurses in intensive care units.Apart from quantitative studies, little is known about individual cases among those high-risk groups.This study evaluates the natural history and cause of second victim traumatization in western austria for the first time to tailor specific intervention.Methods a total of 20 guided interviews were conducted with intensive care nurses in western austria.All interviews were transcribed and analyzed with maxqda software.Evaluation followed the structuring qualitative content analysis scheme according to kuckartz.Results the most frequent symptoms of the second victim phenomenon reported were feelings of guilt and problems with falling asleep.Coping with the second victim phenomenon was accomplished by conversations in private as well as among work colleagues.Conclusions intensive care nurses are exposed to many exceptional situations which have a high likelihood of resulting in second victim traumatization.As proximal psychosocial support is considered to be a main source of coping, wide-spread implementation of effective psychosocial peer support programs ought to be applied by medical organizations.Patient safety measures such as proactive and reactive clinical risk management (e.g., cirs) should be linked to second victim support.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article
An Exploration of the Psychometric Properties of the PASS-20 in Older Adults with Chronic Pain: Preliminary Development and Validity.

S the pain anxiety symptoms scale (pass-20) is well validated in adults and younger populations, but not in older adults.This study aimed to analyze the psychometric properties of the pass-20 in spanish older adults who experience chronic pain.Methods participants were 111 older adults with chronic pain living in nursing homes (mean age = 83.36; sd = 6.53; 78.6% female).Face-to-face interviews were conducted which included assessment of pain anxiety (pass-20), chronic pain acceptance (cpaq), depression symptoms (gds), catastrophizing beliefs (pcs), pain severity, and sociodemographic information.An exploratory structural equation modeling (esem) approach was used to refine the scale.Results the final scale was composed of seven items, measuring two factors that could be labeled "internal experiences" and "escape/avoidance behaviors".The two factors explained 60.98% of the total variance.Pass-7 version fit properly: χ2/df = 14.57/13, cmin/df = 1.121, cfi = 0.99, rmsea = 0.033, tli = 0.98, gfi = 0.96, agfi = 0.92.Good validity indices were found and acceptable reliability results in the scale and its subscales (chronbach ́s α; internal experiences = 0.70; escape/avoidance behaviors= 0.73; total scale = 0.77).Conclusions the short version of the pass-7 has good psychometric properties.Clinical implications the brevity of the pass-7 increases the feasibility of this instrument which could potentially be utilized in a variety of clinical settings and research studies with older people with chronic pain samples, specially institutionalized older adults.

Journal: Clinical gerontologist (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't