syedzayyan/paper_mill_benchmark huggingface dataset:
Optimizing the Prehospital-Hospital Emergency Care Path Application Value in Emergency Treatment of Patients with Cerebral Hemorrhage

To explore the effect of optimizing the prehospital-hospital emergency nursing path on the rescue speed, rescue effect, and patient prognosis of patients with cerebral hemorrhage.Methods.A retrospective study was performed to select 227 patients with acute cerebral hemorrhage who visited our hospital from august 2018 to october 2019, and we compared the optimization of the prehospital-hospital emergency nursing pathway (research group) with traditional prehospital time spent in the rescue and the prognosis of patients in the emergency care pathway (control group) in the hospital.The gos score, fma score, and barthel index were used to compare the prognosis of the two groups of patients.Results.The prehospital-hospital emergency nursing route was optimized compared with the traditional nursing route.The rescue time of patients in each link was shorter ( p &lt; 0.05 ), and the incidence of complications was low ( p &lt; 0.05 ).The scales and scores all suggested that patients had a better prognosis ( p &lt; 0.05 ).Conclusion.Optimizing the prehospital-hospital emergency nursing path can significantly shorten the rescue time, improve the rescue effect, and improve the prognosis of patients.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Clinical Study;
Optimization of Regional Logistics Distribution Information Network Platform

In order to solve the problem of regional logistics distribution, a study on the optimization of regional logistics distribution information network platform is proposed.Firstly, in order to meet the development requirements of regional logistics and improve customer satisfaction, the regional logistics path is optimized to solve the problem of long time consumption for the optimization algorithm of regional logistics distribution path to find the optimal path.The clustering algorithm is used to divide the logistics distribution area, and the multiobjective function of logistics distribution path optimization is established, mainly including weight index, timeliness index, customer importance index, time window index, and total path index.The distribution target weight is set to find the best target path, so as to realize the optimization of regional logistics distribution path.The experimental results show that the time for the designed optimization algorithm to find the optimal path is less than 2 minutes, while the time for the traditional algorithm to find the optimal path is more than 3 minutes, up to 4.6 minutes.The comparison shows that the traditional algorithm takes more time to find the optimal path in five times than the algorithm designed this time.Therefore, the optimization method of this design takes less time to find the optimal path than the traditional method, which proves the effectiveness of the regional logistics distribution path optimization algorithm.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Observation on the Effect of High-Quality Nursing Intervention plus Health Education in Chemotherapy for Non-Small Cell Lung Cancer and Its Influence on the Physical and Mental Health of Patients

The objective is to analyze the effect of high-quality nursing intervention combined with health education in the chemotherapy for non-small cell lung cancer and its impact on the physical and mental health of patients.Methods.The study included 136 patients with non-small cell lung cancer treated at our hospital from march 2020 to december 2021, who were divided into the observation group and the routine/control group by randomization, with 68 patients in each.All patients received the gp (gemcitabine + cisplatin) chemotherapy.The control group received routine nursing care, whereas the observation group received high-quality nursing care mixed with health education.The effect of nursing intervention, patient self-management, and the influence on the physical and mental health of the patients was compared between the two groups.Results.The total efficacy rate (89.71%) of the observation group was significantly higher than that of the routine group (57.35%) ( p &lt; 0.05 ).The self-management level of the patients in the observation group, indicated by the exercise of self-care agency (esca) score, was considerably higher than that of the regular group after nursing intervention.Similarly, the observation group’s quality of life, which was evaluated in terms of physical function, role function, emotional function, cognitive function, social function, and overall health status, was much better than the routine group’s.Furthermore, the sas, sds, and overall incidence of adverse events were lower in the observation group than in the regular group.( p &lt; 0.05 ).Conclusion.The application of high-quality nursing intervention combined with health education in chemotherapy for non-small cell lung cancer has favorable clinical benefits, enhances patient compliance and self-management capacity, and exerts a positive influence on the patient’s physical and mental health.Adverse reactions can provide a more trustworthy scientific basis for therapeutic therapy.The method should be widely used.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Nursing Progress of Hypertonic Saline Inhalation in the Treatment of Infantile Bronchitis Based on Image Enhancement

The onset of bronchiolitis is closely related to the anatomical characteristics of the bronchi in children of this age.This kind of injury is caused by epithelial necrosis, nasal mucosa, and mucosal edema caused by narrowing and blockage of the trachea.Children with this serious phenomenon will have respiratory and heart failure, which threatens the life of children to a large extent.In this paper, based on image enhancement technology, hypertonic saline aerosol inhalation treatment of pediatric bronchiolitis nursing care, through related cases, the application of image enhancement technology in hypertonic saline aerosol inhalation therapy and pediatric bronchiolitis is analyzed, and the tone mapping function is used.Tone mapping functions, hereditary arithmetics, and slope regimes for experimental field capture and detection were used for the objective of therapeutic approaches for the treatment of pediatric capillary pneumonia by hypertonic inhalation.Experimental results show that imaging technology hypertonic inhalation can control the main symptoms of bronchiolitis in infants and young children.Inhalation of 3% saline can shorten the course of moderately chronic children to half a year and can reduce the length of hospital stay by a quarter of the original requires hospitalization time, and the cure rate of pediatric bronchiolitis is increased to 93.7%.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Nursing Diagnosis of Urology Operating Room Based on New Association Classification Algorithm

Due to the rapid development of medical engineering, massive amounts of data are recorded and preserved by various medical instruments.Therefore, finding relationships among data and summarizing clinical manifestations are of great significance to the diagnosis, treatment, and medical research of various diseases.The key to studying the nursing diagnosis support system, particularly in the urological operating room, is to select an effective classification algorithm, which is suitable for the characteristics of urological diseases.Initially, we have analyzed characteristics of urological diseases through medical data mining.Secondly, based on the traditional data mining classification method and urological disease diagnosis research, we have introduced the urological disease experimental source dataset and analyzed characteristics of the disease.Furthermore, classification algorithm and steps were introduced such as decision tree (including id3, c4.5), bayesian classification, bp neural network, and association rule classification algorithms.These algorithms are used to make relevant comparative experiments on the urological disease dataset.Finally, based on the diagnosis of urological diseases, a new association classification algorithm (accf), which is based on frequent closed item sets, is proposed along with suitable explanation.In order to verify the operational capabilities, the proposed algorithms are implemented in c++ and compared with the classification effect of traditional association classification algorithms and data mining methods.Both theoretical analysis and experiment results show that the proposed algorithm has resolved various deficiencies of the existing data mining algorithms and equally improved the accuracy of urological disease classification and prediction.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
New Approach for Targeted Treatment of Mild COVID-19 by Honeysuckle through Network Pharmacology Analysis

To investigate the potential pharmacological value of extracts from honeysuckle on patients with mild coronavirus disease 2019 (covid-19) infection.Methods.The active components and targets of honeysuckle were screened by traditional chinese medicine database and analysis platform (tcmsp).Swiss adme and pk csm databases predict pharmacokinetics of ingredients.The gene expression omnibus (geo) database collected transcriptome data for mild covid-19.Data quality control, differentially expressed gene (deg) identification, enrichment analysis, and correlation analysis were implemented by r toolkit.Cibersort evaluated the infiltration of 22 immune cells.Results.The seven active ingredients of honeysuckle had good oral absorption and medicinal properties.Both the active ingredient targets of honeysuckle and differentially expressed genes of mild covid-19 were significantly enriched in immune signaling pathways.There were five overlapping immunosignature genes, among which rela and map3k7 expressions were statistically significant ( p &lt; 0.05 ).Finally, immune cell infiltration and correlation analysis showed that rela, map3k7, and natural killer (nk) cell are with highly positive correlation and highly negatively correlated with hematopoietic stem cells.Conclusion.Our analysis suggested that honeysuckle extract had a safe and effective protective effect against mild covid-19 by regulating a complex molecular network.The main mechanism was related to the proportion of infiltration between nk cells and hematopoietic stem cells.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Network Pharmacology-Based Study on the Active Component and Mechanism of the Anti-Gastric-Cancer Effect of Herba Sarcandrae

Herba sarcandrae is used in the clinical practice of traditional chinese medicine to deal with gastric cancer.However, there are few studies on its precise mechanism.Method.In this study, a network pharmacological approach was utilized to construct a molecular/target/pathway molecular regulatory network for the anti-gastric-cancer effect of herba sarcandrae.The active components of herba sarcandrae and their potential mechanisms were explored.Chemical components of the herba sarcandrae were identified through a database, and they were evaluated and screened based on oral bioavailability and drug similarity.Results.Genes related to gastric cancer were found in the gene expression omnibus (geo) database, and gene targets related to anti-gastric-cancer were chosen by comparison.Using annotation, visualization, and a comprehensive discovery database, the function and related pathways of target genes were analyzed and screened.Cytoscape software was utilized to construct a component/target/pathway network for the antitumor effect of herba sarcandrae.Finally, 6 drug ingredients and 29 target genes related to gastric cancer were detected.Il-17 signaling pathway, nf-kappa b signaling pathway, and other signaling pathways were significantly enriched.Many signaling pathways that directly act on tumors and indirect pathways inhibit the development of gastric cancer.Conclusion.This study provides a scientific basis for further elucidating the mechanism of the anti-gastric-cancer effect of herba sarcandrae.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Network Pharmacology Reveals Polyphyllin II as One Hit of Nano Chinese Medicine Monomers against Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma (npc) is a malignant tumor in southern china, and nano traditional chinese medicine (tcm) represents great potential to cancer therapy.To predict the potential targets and mechanism of polyphyllin ii against npc and explore its possibility for the future nano-pharmaceutics of chinese medicine monomers, network pharmacology was included in the present study.Totally, ninety-four common potential targets for npc and polyphyllin ii were discovered.Gene ontology (go) function enrichment analysis showed that biological processes and functions mainly concentrated on apoptotic process, protein phosphorylation, cytosol, protein binding, and atp binding.In addition, the anti-npc effects of polyphyllin ii mainly involved in the pathways related to cancer, especially in the pi3k-akt signaling indicated by the kyoto encyclopedia of genes and genomes (kegg) analysis.The “drug-target-disease” network diagram indicated that the key genes were src, mapk1, mapk14, and akt1.Taken together, this study revealed the potential drug targets and underlying mechanisms of polyphyllin ii against npc through modern network pharmacology, which provided a certain theoretical basis for the future nano tcm research.

Journal: Bioinorganic Chemistry and Applications (2021)
Publication types: Research Article;
Network Pharmacology Prediction: The Possible Mechanisms of Cinobufotalin against Osteosarcoma

To explore the active compounds and targets of cinobufotalin (huachansu) compared with the osteosarcoma genes to obtain the potential therapeutic targets and pharmacological mechanisms of action of cinobufotalin on osteosarcoma through network pharmacology.Methods.The composition of cinobufotalin was searched by literature retrieval, and the target was selected from the ctd and tcmsp databases.The osteosarcoma genes, found from the gene cards, omim, and other databases, were compared with the cinobufotalin targets to obtain potential therapeutic targets.The protein-protein interaction (ppi) network of potential therapeutic targets, constructed through the string database, was inputted into cytoscape software to calculate the hub genes, using the network analyzer.The hub genes were inputted into the kaplan-meier plotter online database for exploring the survival curve.Functional enrichment analysis was identified using the david database.Results.28 main active compounds of cinobufotalin were explored, including bufalin, adenosine, oleic acid, and cinobufagin.128 potential therapeutic targets on osteosarcoma are confirmed among 184 therapeutic targets form cinobufotalin.The hub genes included tp53, actb, akt1, myc, casp3, jun, tnf, vegfa, hsp90aa1, and stat3.Among the hub genes, tp53, actb, myc, tnf, vegfa, and stat3 affect the patient survival prognosis of sarcoma.Through function enrichment analysis, it is found that the main mechanisms of cinobufotalin on osteosarcoma include promoting sarcoma apoptosis, regulating the cell cycle, and inhibiting proliferation and differentiation.Conclusion.The possible mechanisms of cinobufotalin against osteosarcoma are preliminarily predicted through network pharmacology, and further experiments are needed to prove these predictions.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
NDRG4 Alleviates Myocardial Infarction-Induced Apoptosis through the JAK2/STAT3 Pathway

At present, studies have confirmed that ndrg4 is specifically expressed in the heart, while its effect on the heart is still unclear.This study is to explore the effect of ndrg4 on cardiomyocyte apoptosis caused by acute myocardial infarction (ami).Methods.Twenty sd rats were randomly divided into sham (left anterior descent of heart without ligation) and ami groups.In this study, coronary artery ligation was used to establish an ami model, and the ami model was verified by auxiliary examination and pathological examination.Besides, quantitative real-time polymerase chain reaction (q rt-pcr) and western blotting (wb) was used to detect the expression level of bax and bcl-2 in heart tissues, and ndrg m rna levels in tissues were also detected.Q rt-pcr technology was used to verify the transfection efficiency of ndrg4 in h9c2 cells, and the change of apoptosis level of h9c2 cells was detected by cell counting kit-8 (cck-8) assay and tunel staining; besides, the expression level of apoptosis-related factors was detected by wb and q rt-pcr technology.Simultaneously with the modeling of rats, we injected adenovirus (ad) into the heart tissue and examined the structural and functional changes of the rat heart.Then, wb technology was used to detect the expression level of the jak2/stat3 signaling pathway.Results.The heart function and heart structure of rats in the mi group were dramatically worse, and the expression level of ndrg4 was also dramatically reduced.The overexpression of ndrg4 in h9c2 cells can effectively inhibit the ischemia/hypoxia- (i/h-) induced decrease in cell viability and increase in apoptosis rate and inhibit the increase in bax/bcl-2 ratio.Moreover, overexpression of ndrg4 in heart tissue can effectively improve the cardiac function and structural destruction caused by mi.In addition, ndrg4 can inhibit jak2/stat3 pathway activation.Conclusion.The expression of ndrg4 in the mi tissue of rats was suppressed, while overexpression of ndrg4 by injection of ad can obviously protect the rat heart.Furthermore, overexpression of ndrg4 in h9c2 cells can effectively inhibit the i/h-induced decrease in cell viability and increase in apoptosis rate, and this may be related to the inhibition of the jak2/stat3 signaling pathway.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Nanoparticles for Oral Cancer Diagnosis and Therapy

Oral cancer is the sixth most common malignant cancer, affecting the health of people with an unacceptably high mortality rate.Despite numerous clinical methods in the diagnosis and therapy of oral cancer (e.g., magnetic resonance imaging, computed tomography, surgery, and chemoradiotherapy), they still remain far from optimal.Therefore, an urgent need exists for effective and practical techniques of early diagnosis and effective therapy of oral cancer.Currently, various types of nanoparticles have aroused wide public concern, representing a promising tool for diagnostic probes and therapeutic devices.Their inherent physicochemical features, including ultrasmall size, high reactivity, and tunable surface modification, enable them to overcome some of the limitations and achieve the expected diagnostic and therapeutic effect.In this review, we introduce different types of nanoparticles that emerged for the diagnosis and therapy of oral cancers.Then, the challenges and future perspectives for nanoparticles applied in oral cancer diagnosis and therapy are presented.The objective of this review is to help researchers better understand the effect of nanoparticles on oral cancer diagnosis and therapy and may accelerate breakthroughs in this field.

Journal: Bioinorganic Chemistry and Applications (2021)
Publication types: Review Article;
Music Intervention to Orthopedic Patients: A Possible Alternative Solution to Control Pain

S and objective.Pain is a common problem associated with postoperative orthopedic patients; the current study is aimed at evaluating music intervention as an alternative method to control pain.Methodology.The experimental design of the current study was comparative, descriptive, and quasi-experimental.38 postoperative orthopedic patients were equipped with pocket-size mp3 players with prerecorded music tracks (instrumental and lyrical) in hindi, english, and urdu.After that, pre-post-pain scores were recorded with the help of designed brief patient logs.Ultimately, a satisfactory survey was completed at discharge.Major findings.It was found that during the intervention of music, the pain was significantly reduced from 5.40 to 2.98.There was a slight relationship between listening time and pain relief.It was also found that the feedback was extremely positive and each patient suggested the use of music to others with 96.6% recommendation.Conclusion.From the current study, it was found that music intervention can be beneficial to postoperative patient pain control.Further, it is hoped that the findings of the current experimental work will lead to improvements in the care of postoperative patients.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
Multislice Computed Tomography Angiography Imaging Diagnosis of Lower Extremity Arteriosclerosis in Patients with Hypertension and Its Correlation with the Level of High-Sensitivity C-Reactive Protein

The aim of this study was to investigate the relationship between multislice computed tomography (ct) angiography (mscta) imaging and high-sensitivity c-reactive protein (hs-crp) in patients with hypertension and lower extremity arteriosclerosis.68 hypertensive patients with lower extremity arteriosclerosis were selected as the observation group, and 68 healthy volunteers were selected as the control group to compare the differences in hs-crp.According to the degree of stenosis, the patients were further divided into five grades: no obvious stenosis, mild stenosis, moderate stenosis, severe stenosis, and occlusion.The correlation between the degree of stenosis and the content of hs-crp was compared.The changes of hs-crp content before and after treatment were compared, and the difference of images before and after surgical treatment and the difference of hs-crp expression in patients with occlusion were compared.Compared with the control group, the content of hs-crp in the observation group was significantly higher ( p &lt; 0.05 ), and the degree of stenosis was positively correlated with the content of hs-crp.After two weeks of treatment, the hs-crp levels of patients with severe stenosis and occlusion were significantly lower than those before treatment ( p &lt; 0.01 ).The level of hs-crp in patients with occlusion after arterial stent intervention was significantly lower than before, and the images also showed that the blood vessels were significantly expanded.The degree of stenosis in patients with lower extremity arteriosclerosis diagnosed by mscta imaging was closely related to the expression of hs-crp in the patient, and a sustained high concentration of hs-crp corresponded to a more severe degree of vascular occlusion.In conclusion, the hs-crp can be used as one of the factors to predict and evaluate the occurrence of cardiovascular and cerebrovascular diseases.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;