syedzayyan/paper_mill_benchmark huggingface dataset:
Barriers and potential solutions to international collaboration in neuro-oncology clinical trials: Challenges from the Australian perspective.

The neuro-oncology community in australia is well positioned to collaborate internationally, with a motivated trials group, strong regulatory bodies and an attractive fiscal environment.We sought to identify gaps in the australian neuro-oncology clinical trials landscape and describe strategies to increase international trial access in australia.Methods we searched clinical trial registries to identify active adult primary brain cancer trials.We compared the participation rate and phase of these trials between tumour types and countries.A survey was distributed to the cooperative trials group for neuro-oncology membership to identify barriers and solutions to effective international collaboration.Results globally, 307 trials for adult primary brain cancers were identified.These included 50% pharmaceutical agents, 18% cellular therapies and 9% radiation therapy.Twelve adult primary brain cancer trials were actively recruiting in australia at the time the survey was sent out.There were more early phase brain cancer trials (34%) compared with colorectal and breast cancer (21% and 24%, respectively).In australia, 92% of brain cancer trials were involving pharmaceutical agents.The most commonly cited barrier was lack of funding for international trials (86%) and insufficient research time (75%).High ranking solutions included increasing the availability of funding for international trials and creating opportunities to develop personal relationships with collaborators.Accreditation of clinical research key performance indicators into practice (88%) and hospital accreditation (73%) also ranked highly.Conclusions participation in international research in australia could be improved by embedding clinical research targets into institutional funding, provision of funding for early phase studies and streamlining mutual ethics schemes.

Journal: Asia-Pacific journal of clinical oncology (2022)
Publication types: Journal Article
Wearing the Future-Wearables to Empower Users to Take Greater Responsibility for Their Health and Care: Scoping Review.

Wearables refer to devices that are worn by individuals.In the health care field, wearables may assist with individual monitoring and diagnosis.In fact, the potential for wearable technology to assist with health care has received recognition from health systems around the world, including a place in the strategic long term plan shared by the national health service in england.However, wearables are not limited to specialist medical devices used by patients.Leading technology companies, including apple, have been exploring the capabilities of wearable health technology for health-conscious consumers.Despite advancements in wearable health technology, research is yet to be conducted on wearables and empowerment.Objective this study aimed to identify, summarize, and synthesize knowledge on how wearable health technology can empower individuals to take greater responsibility for their health and care.Methods this study was a scoping review with thematic analysis and narrative synthesis.Relevant guidance, such as the arksey and o'malley framework, was followed.In addition to searching gray literature, we searched medline, embase, psyc info, hmic, and cochrane library.Studies were included based on the following selection criteria: publication in english, publication in europe or the united states, focus on wearables, relevance to the research, and the availability of the full text.Results after identifying 1585 unique records and excluding papers based on the selection criteria, 20 studies were included in the review.On analysis of these 20 studies, 3 main themes emerged: the potential barriers to using wearables, the role of providers and the benefits to providers from promoting the use of wearables, and how wearables can drive behavior change.Conclusions considerable literature findings suggest that wearables can empower individuals by assisting with diagnosis, behavior change, and self-monitoring.However, greater adoption of wearables and engagement with wearable devices depend on various factors, including promotion and support from providers to encourage uptake; increased short-term investment to upskill staff, especially in the area of data analysis; and overcoming the barriers to use, particularly by improving device accuracy.Acting on these suggestions will require investment and constructive input from key stakeholders, namely users, health care professionals, and designers of the technology.As advancements in technology to make wearables viable health care devices have only come about recently, further studies will be important for measuring the effectiveness of wearables in empowering individuals.The investigation of user outcomes through large-scale studies would also be beneficial.Nevertheless, a significant challenge will be in the publication of research to keep pace with rapid developments related to wearable health technology.

Journal: JMIR mHealth and uHealth (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't
Apparent posterior cerebral artery territory perfusion asymmetry on arterial spin labeling MRI is a common non-pathologic finding in patients with a unilateral fetal posterior cerebral artery.

To determine the frequency of apparent posterior cerebral artery (pca) territory asymmetry seen on arterial spin labeling (asl) imaging in patients with a unilateral fetal pca, but without underlying clinical or imaging pathology to suggest true hypoperfusion.Methods a search of radiology reports from 1/2017 through 6/2020 was performed with the inclusion term "fetal pca." eighty patients were included with unilateral fetal pca confirmed on mra or cta, with brain mri including asl imaging, and without conventional imaging abnormality or clinical symptoms referable to the pca territories.Cases were evaluated by two independent readers for visually apparent pca perfusion asymmetries.Asl imaging consisted of pseudocontinuous asl with 1.5 s labeling duration and 2 s post-labeling delay adapted from white paper recommendations.Results thirteen of 80 cases (16.2%) had apparent hypoperfusion in the pca territory contralateral to the side of the fetal pca.Agreement between readers was near perfect (97.5%, κ = 0.91).This finding was more common in patients who were older, scanned on a 3.0 t magnet, and who had non-visualization of the posterior communicating artery contralateral to the fetal pca.Conclusion apparent pca hypoperfusion on asl is not uncommon in patients with a contralateral fetal pca who have no clinical or conventional imaging findings to suggest true hypoperfusion.This phenomenon is likely due to differential blood velocities between the carotid and vertebral arteries that result in differential arterial transit times and labeling efficiency.It is important for radiologists to know that apparent hypoperfusion may arise from variant circle of willis anatomy.

Journal: Neuroradiology (2022)
Publication types: Journal Article
Complete mitochondrial genome and phylogenetic analysis ofIxodes ovatus(Acari: Ixodidae).

Ixodes ovatusis referred to as an obligatory blood-sucking ectoparasite that is capable to infest both humans and animals.In the present study, the complete mitochondrial genome of i.Ovatuswas sequenced and analyzed using next-generation sequencing (ngs) technology.With a size of 14,520 bp, the entire mitogenome contains 37 genes including 13 protein-coding genes (pcgs), 22 transfer rnas (t rnas), 2 ribosomal rnas (r rnas), and 3 control regions (d-loops).Based on the 13 pcgs nucleotide sequences, the phylogenetic relationship of i.Ovatuswas analyzed using maximum-likelihood.As suggested by the results of the obtained phylogenety,i.Ovatusis most closely associated with ixodes hexagonus.this study is expected to promote further studies on the evolution of ixodidae.

Journal: Mitochondrial DNA. Part B, Resources (2022)
Publication types: Journal Article
Preparation, Characterization, and Biological Evaluation of Transparent Thin Carboxymethyl-Chitosan/Oxidized Carboxymethyl Cellulose Films as New Wound Dressings.

Full thickness burns in which the damage penetrates deep into the skin layers and reaches underneath the muscle, compel the need for more effective cure.Herein, cross-linked carboxymethyl-chitosan (cm-chitosan) films, prepared by schiff base association with oxidized carboxymethyl cellulose (ocmc), are investigated regarding the wound healing capacity on full thickness burn injuries in vivo.Transparent thin cm-chitosan/ocmc films are obtained with tensile strength reaching 6.11 mpa, elongation at break above 27%, and water absorption more than 800%, which operates in favor of absorbing excess exudate and monitoring the wound status.Furthermore, the nonadherent cm-chitosan/ocmc films, with satisfactory biodegradability, cell, and tissue compatibility, are readily used to the wound sites and easily removed following therapy on scalded tissue so as to alleviate the suffering from burn.The films efficiently promote epithelial and dermal regeneration compared to the control, achieving 75.9% and 94.4% wound closure, respectively, after 14 and 27 days.More importantly, cm-chitosan/ocmc films accelerate wound healing with natural mechanisms which include controlling inflammatory response, reducing apoptosis, promoting fibroblast cell proliferation, and collagen formation.In conclusion, the cm-chitosan/ocmc films elevate the repair ratio of burn injuries and have great potential for facilitating the healing process on full-thickness exuding wounds.

Journal: Macromolecular bioscience (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Competitive Impedance Spectroscopy in a Schottky-Contacted ZnO Nanorod Structure for Ultrasensitive and Specific Biosensing in a Physiological Analyte.

To enable detection and discovery of biomarkers, development of label-free, ultrasensitive, and specific sensors is the need of the hour.For addressing this requirement, here, a schottky-contacted zn o nanorod biosensor has been demonstrated, which explores the interplay between schottky junction capacitance and solution resistance, resulting in an interesting sensing principle of competitive impedance spectroscopy.When the transition of dominating impedance occurs from solution resistance to junction capacitance, a notch or a peak appears in the impedance response at a particular frequency (referred to as the corner frequency) depending on the charge of the target molecule.The appearance of the peak or notch acts like an electronic label for selectivity since it is visible only for target molecules even at ultralow concentrations in the physiological analyte, where the magnitude of impedance change overlaps with that for nonspecific molecules.This phenomenon has been successfully applied for the positively charged vascular endothelial growth factor (vegf) and the negatively charged hepatitis b surface antigen (hbs ag), where the shifts in the higher corner frequencies for 1 a m concentration of the target molecules have been observed to be more than 3 times the changes in the impedance magnitude.Further, the area of the zn o nanorods was segmented into two zones corresponding to the lower and higher concentration regimes, thereby expanding the dynamic range.To summarize, an ultralow detection limit of 1 a m with a dynamic range up to 1 p m was achieved for vegf and hbs ag, which is 4 orders of magnitude and 20 times lower than their most sensitive label-free reports, respectively.

Journal: ACS sensors (2022)
Publication types: Journal Article
Research on shifting process control of automatic transmission.

The shift quality of an automatic transmission directly affects the human-perceived comfort and the durability of the automatic transmission.In general, the inconsistency caused by manufacturing errors, life-cycle changes, or other changes in hydraulic characteristics are the main reason affecting the shift quality, which should be compensated by adaptive control in the shifting process.In this paper, we first provide an in-depth analysis of the relationship between proportional solenoid current, clutch pressure, speed and torque in the shifting process control.Then we propose two efficient adaptive control strategies for the torque phase and inertia phase, respectively.Both algorithms are tested and verified on a riot utility vehicle.The experimental results indicate that the adaptive control strategies proposed in this paper can effectively compensate the engine flare and the clutch tie-up of the torque phase, and keep the inertia phase within a proper time range.

Journal: Scientific reports (2022)
Publication types: Journal Article
Pyrolysis of blend (oil palm biomass and sawdust) biomass using TG-MS.

The aim of this study was to pyrolyze individual (oil palm shell, empty fruit bunch and sawdust) as well as blend biomass in a thermogravimetric mass spectrometry (tg-ms) from room temperature to 800 °c at constant heating rate of 15 °c/min.The results showed that the onset tg temperature for blend biomass shifted slightly to lower values.Activation energy values were also found to decrease slightly after blending the biomass.Interestingly, the ms spectra of selected gases (h2o ch4, h2o, c2h2, c2h4or co, ch2o, ch3oh, hcl, c3h6, co2, hcooh, and c6h12) evolved from blend biomass showed decreased in the intensity as compared to their individual biomass.Overall, the blend biomass showed synergy which provides ways to expand the possibility of utilizing multiple feedstocks in one thermo-chemical system.

Journal: Bioresource technology (2019)
Publication types: Journal Article
Multistable circular currents of polariton condensates trapped in ring potentials.

We demonstrate the formation and trapping of different stationary solutions, oscillatory solutions, and rotating solutions of a polariton condensate in a planar semiconductor microcavity with a built-in ring-shaped potential well.Multistable ring-shaped solutions are trapped in shallow potential wells.These solutions have the same ring-shaped density distribution but different topological charges, corresponding to different orbital angular momentum (oam) of the emitted light.For stronger confinement potentials, besides the fundamental modes, higher excited (dipole) modes can also be trapped.If two modes are excited simultaneously, their beating produces a complex oscillation or rotation dynamics.When the two modes have the same oam, a double-ring solution forms for which the density oscillates between the inner and the outer ring.When the two modes have different oam, a rotating solution with fractional oam is created.

Journal: Optics letters (2020)
Publication types: Journal Article
vHTS, 3-D Pharmacophore, QSAR and Molecular Docking Studies for the Identification of Phyto-derived ATP-Competitive Inhibitors of the BCR-ABL Kinase Domain.

Chronic myelogenous leukaemia (cml) constitutes about 15 % of adult leukaemia and is characterized by the overproduction of immature myeloid cells.Methods in this study, a virtual high throughput screening (v hts) technique was employed to screen a library of phytochemicals of reported plants having anticancer activity.A docking score of -10 kcalmol-1was used as the cut-off for the selection of phyto-compounds for pharmacophore-based virtual screening.Statistically robust and thoroughly validated qsar model (r = 0.914, r2= 0.836, adjusted r2= 0.764, loo-cv= 0.6680) was derived for the inhibition of bcr-abl kinase domain.Results the virtual screening, pharmacophore screening, qsar model and molecular docking techniques applied herein revealed ellagic acid, a polyphenolic compound, as a potential competitive inhibitor of the bcr-abl kinase domain.Ellagic acid binds to the inactive abl state and forms similar interactions with key residues within the bcr-abl kinase domain as obtained in ponatinib (having inhibitory effects on the abl thr-315i mutant).It forms hydrogen bond interaction with thr-315 residue (the gatekeeper residue).It is not likely to be prone to the various mutations associated with nilotinib because of its small size.Conclusion the procedure of vhts, pharmacophore, qsar, and molecular docking applied in this study could help in detecting more anti-cml compounds.

Journal: Current drug discovery technologies (2022)
Publication types: Journal Article
Activation of the TGF-βPathway Enhances the Efficacy of Platinum-Based Chemotherapy in Small Cell Lung Cancer Patients.

Platinum-based chemotherapy is the first choice of treatment for patients diagnosed with small lung cell cancer (sclc).However, many patients exhibit resistance to it.Therefore, it is imperative to further investigate a prognostic biomarker indicating sensitivity to this therapy.Methods we collected and performed rna sequencing on 45 sclc samples from the zhujiang hospital (local-sclc).In addition, we used a public cohort from george et al.As a validation cohort (george-sclc).The transforming growth factorβsignaling pathway (tgfb) activation status was determined according to the related ss gsea score.We analyzed immune cell ratios, pathway activation scores, and immune-related genes in sclc patients to further elucidate the potential mechanisms.Results a high activation status of the tgfb pathway was associated with improved prognosis in sclc patients receiving platinum-based chemotherapy (local-sclc: hr = 0.0238, (95% ci, 0.13-0.84),p= 0.0238; george-sclc: hr = 0.0315, (95% ci, 0.28-0.98),p= 0.0315).Immune infiltration analysis showed that the tgfb-high group had more m1 macrophages and th1 cells, whilst fewer m2 macrophages, th2 cells, and treg cells were found in the local-sclc cohort.Mechanistic analysis showed that the tgbf-high group was upregulated in sting-mediated immunity, apoptosis, and cell cycle arrest, as well as being downregulated in the process of dna damage repair.Conclusions sclc patients exhibiting a high activation status of the tgfb pathway demonstrate an improved prognosis with platinum-based chemotherapy.The potential underlying mechanism may be related to antitumor immune enhancement and dna damage repair inhibition.

Journal: Disease markers (2022)
Publication types: Journal Article
Does habitat heterogeneity influence taxonomic richness and abundance? A case study from a terrestrial protected area in Abu Dhabi, United Arab Emirates.

Biodiversity is under enormous pressure from multiple threats including climate change, land use change, habitat alterations and hunting pressure.One way to ease this pressure on biodiversity and to mitigate the effects of above-mentioned threats, is to establish protected areas.Importance of protected increases many folds in regions that are considered as biodiversity poor regions i.e.Deserts.Protected areas have long been a major pillar of biodiversity conservation strategies; the houbara protected area (hpa) is one of the 13 terrestrial protected areas in abu dhabi emirate officially declared in 2017.However, no information regarding the status of biodiversity in the hpa has been communicated to the research fraternity.During the present study, surveys were conducted to fill this gap.The survey area was divided in to 50 grids of 5 × 5 km2and monitoring surveys were undertaken from january to december 2016.A total of 14 bi-monthly to monthly surveys were conducted within hpa and 196 species of different taxonomical groups were recorded.A year-long survey yielded highly diversified fauna and flora from 19 different habitat types (h) 1.32, (e) 2.28, shannon diversity index).We looked at the influence of habitat breadth and temperature on the species richness and abundance, results shows that in desert setup heterogeneity of habitat is not an important factor in maintaining the biodiversity as total number of individuals as well as species were similar in the grids that have different number of habitat types (df = 34.3, t = -0.472, p = 0.640).However, we did find a positive impact of mean monthly temperature on species richness (df = 154, t = 2.53, p = 0.012).Our study highlights the importance of temperature in driving species abundance and richness in protected area.Abundance and species richness are similar in protected areas indicating that protection is allowing species to explore the heterogenous habitats.Overall, we can conclude that protection is beneficial for species.

Journal: Saudi journal of biological sciences (2022)
Publication types: Journal Article
Integrity of Organic Foods and Their Suppliers: Fraud Vulnerability Across Chains.

Organic foods are frequently targeted by fraudsters.Examination of underlying factors helps to reduce fraud vulnerability and to prevent fraud.In this study, the fraud vulnerability of five actors from each of four chains were examined using the ssafe food fraud vulnerability assessment tool: the organic banana, egg, olive oil and pork supply chains.The organic chains appeared slightly less vulnerable than conventional chains due to fewer opportunities for fraud and the more adequate controls being present.On the other hand, organic chains were associated with enhanced vulnerability resulting from cultural and behavioral drivers.Generally, actors in the organic olive oil and pork chains were more vulnerable than those from the banana and egg chains.However, high risk actors were not limited to particular chains.Across the whole group of actors in organic chains, three groups in terms of cultural/behavioral drivers were distinguished: a low vulnerability group, a group facing more external threats and a group presenting fraud vulnerability in general and in particular from within their own company.Ethical business culture and criminal history scores of businesses correlated significantly.This implies that the climate in a company is an important factor to consider when estimating the exposure of businesses to food fraud.

Journal: Foods (Basel, Switzerland) (2020)
Publication types: Journal Article
The Autoimmune Risk R262W Variant of the Adaptor SH2B3 Improves Survival in Sepsis.

The single-nucleotide polymorphism (snp) rs3184504 is broadly associated with increased risk for multiple autoimmune and cardiovascular diseases.Although the allele is uniquely enriched in european descent, the mechanism for the widespread selective sweep is not clear.In this study, we find the rs3184504*t allele had a strong association with reduced mortality in a human sepsis cohort.The rs3184504*t allele associates with a loss-of-function amino acid change (p.r262w) in the adaptor protein sh2b3, a likely causal variant.To better understand the role of sh2b3 in sepsis, we used mouse modeling and challenged sh2b3-deficient mice with a polymicrobial cecal-ligation puncture (clp) procedure.We found sh2b3 deficiency improved survival and morbidity with less organ damage and earlier bacterial clearance compared with control mice.The peritoneal infiltrating cells exhibited augmented phagocytosis in sh2b3-/-mice with enriched recruitment of ly6chiinflammatory monocytes despite equivalent or reduced chemokine expression.Rapid cycling of monocytes and progenitors occurred uniquely in the sh2b3-/-mice following clp, suggesting augmented myelopoiesis.To model the hypomorphic autoimmune risk allele, we created a novel knockin mouse harboring a similar point mutation in the murine pleckstrin homology domain of sh2b3.At baseline, phenotypic changes suggested a hypomorphic allele.In the clp model, homozygous knockin mice displayed improved mortality and morbidity compared with wild-type or heterozygous mice.Collectively, these data suggest that hypomorphic sh2b3 improves the sepsis response and that balancing selection likely contributed to the relative frequency of the autoimmune risk variant.

Journal: Journal of immunology (Baltimore, Md. : 1950) (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't