syedzayyan/paper_mill_benchmark huggingface dataset:
COVID-19 Related Stresses, Conspiracy Beliefs, Uncertainty, and Non-adherence to Safety Guidelines.

Introduction inconsistent use of protective preventive measures and nonadherence of the guidelines set by the world health organization regarding the coronavirus are associated with increased morbidity and mortality, as well as increased health care costs.Objective the purpose of this study was to examine the role of covid-19 related worries, conspiracy beliefs, and uncertainty in adherence to preventative measures in iran.Method in a large survey with data collected online from a volunteer sample of 599 individuals, assessments were made of the distress associated with the anticipated potential consequences associated with the covid-19 pandemic and the lockdown, extent of agreement with conspiracy beliefs, level of situation-specific uncertainty, and self-reports of compliance with preventive measures.Data were analyzed to explore paths leading to nonadherence to safety guidelines proposed by the medical authorities.Results a large majority of individuals report significant distress and worry associated with the covid-19 pandemic.Results indicate that increasing levels of situation-specific uncertainty intolerance, as well as conspiracy beliefs regarding the coronavirus, are associated with non-compliance with the advised protocols.Specifically, the results show that worries related to the covid-19 pandemic are linked to non-compliance with preventive measures through conspiracy beliefs and feelings of uncertainty associated with the covid-19 situation even after gender, education, and perceived socioeconomic status were controlled.Conclusions findings imply that emotional exhaustion is likely to have set in and become counterproductive as people choose to violate safety guidelines.The authors discuss the theoretical and practical implications of these results.

Journal: International journal of psychological research (2022)
Publication types: Journal Article
Entry of the antipsychotic drug, olanzapine, into the developing rat brain in mono- and combination therapies.

Olanzapine is used to treat schizophrenia and bipolar disorder in women of childbearing age.Continuation of psychotropic medications throughout pregnancy and lactation is often required as cessation could be dangerous for both mother and child.However, there is a lack of information on the transfer of these drugs into the developing brain.methods:sprague dawley rats at three developmental ages: embryonic day e19, postnatal day p4 and non-pregnant adult females were administered unlabelled or radiolabelled (3h) olanzapine (0.15 mg/kg) either as monotherapy or in combination with each of seven other common medications.Similar injections were administered to pregnant e19 females to investigate placental transfer.Olanzapine in plasma, cerebrospinal fluid (csf) and brain was measured by liquid scintillation counting after a single dose (acute) or following 5 days of treatment (prolonged).results:olanzapine entry into brain and csf was not age-dependent.Prolonged olanzapine treatment reduced placental transfer from 53% to 46% (p<0.05).Co-administration of digoxin or lamotrigine with olanzapine increased its entry into the fetal brain, whereas paracetamol decreased its entry into the csf.Placental transfer of olanzapine was increased by co-treatment with cimetidine and digoxin, whereas co-treatment with lamotrigine, paracetamol or valproate led to a substantial decrease.Repeated co-treatment of digoxin and olanzapine increased olanzapine transfer into the brain and csf, but not across the placenta.Overall entry of olanzapine from maternally administered drugs into the fetal brain was higher after combination therapy with cimetidine and digoxin.conclusions:co-administration of olanzapine with some commonly used drugs affected its entry into the fetus and its developing brain to a greater extent than in adults.It appears that protection of the fetal brain for these drugs primarily comes from the placenta rather than from the fetal brain barriers.Results suggest that drug combinations should be used with caution particularly during pregnancy.

Journal: F1000Research (2022)
Publication types: Journal Article
Platelet rich plasma enhanced neuro-regeneration of human dental pulp stem cellsin vitroand in rat spinal cord.

Human dental pulp stem cells (h dpscs) exhibit excellent differentiation potential and are capable of differentiating into several different cellular phenotypes, including neurons.Platelet-rich plasma (prp) contains numerous growth factors that can stimulate stem cell differentiation.In this study, we investigated the potential stimulatory effects of prp on neurogenic differentiation and anti-apoptosis of h dpscs in injured spinal cords.Methods the unipotential differentiation capacity of h dpscs was analyzed by cell surface antigen identification and cell cycle analysis.A spinal cord injury rat model composed of 40 sprague-dawley (sd) rats was used to facilitate anin vivostudy.Rats were divided into four groups: a double-treatment group (receiving both neurogenic-induced h dpscs and prp), two single-treatment groups (receiving neurogenic-induced h dpscs or prp) and a sham group (receiving normal saline).The basso, beattie, bresnahan locomotor rating scale was subsequently used to evaluate the motor function of the spinal cord.Cell viability and differentiation of h dpscs in the damaged spinal cords were analyzed and apoptosis of neural cells was evaluated using the terminal uridine nucleotide end labeling (tunel) assay.Results growth pattern, cell surface marker and cell cycle analyses revealed that h dpscs have a high degree of multi-directional differentiation potential and can be induced into neuronsin vitro.In the rat spinal cord injury model, double-treatment with h dpsc/prp or single treatment with h dpscs or prp significantly improved motor function compared with the sham group (p<0.05).Apoptosis of neural cells was observed to be significantly higher in the sham group compared to any of the treatment groups.Double-treatment with h dpscs and prp resulted in the lowest apoptotic rate among the groups analyzed.Conclusions h dpscs exhibit differentiation potential and are capable of transforming into neural cells bothin vitroandin vivo.Significantly increased inhibition of neuronal apoptosis and improved motor function recovery of the spinal cord were observed following double-treatment with h dpscs and prp compared with the single-treatment groups.

Journal: Annals of translational medicine (2022)
Publication types: Journal Article
The introduction of a Parkinson's disease email alert system to allow for early specialist team review of inpatients.

Patients with parkinson's disease (pwp) have complex healthcare needs, and compared to the general population, are more likely to have an unplanned emergency department (ed) attendance to hospital, along with poorer outcomes.Innovative methods of notification, when patients have an ed attendance are needed to allow for earlier specialist team interventions.This study describes the introduction of an email alert (e-alert) for a specialist parkinson's team.In addition, the reason for admission, specialist team interventions, length of stay, frequency of readmission, discharge destination, mortality and the bed cost per ed attendance or admission episode will be explored.Methods the e-alert was developed in collaboration with academics, a parkinson's specialist team and hospital information technology (it) specialists, by employing existing software and it system platforms.Patients were identified from an existing hospital patient administration and a specialist movement disorder database.Specific variables along with routine patient data were collected including demographics, clinical variables, specialist team interventions, reason for admission, length of stay, discharge destination, unscheduled readmission, mortality and bed cost per day.Results the initial programming and setup of the e-alert was estimated to be around £3000.In its first six months, the e-alert identified 75 ed attendances, with the most common reasons being, falls and infections.The overall mean los was 6.8 days, with 25/75 patients being readmitted within 28 days.The most common specialist team clinical interventions were changes in medication, assessment for postural hypotension, neuropsychiatric and swallowing assessments.The majority of patients (92%) were discharged to their normal place of residence.The crude mortality rate for the cohort was approximately twice that of the hospital average.The total ed and acute bed cost was estimated to be £354,805.88, with exponential rises in healthcare costs when los was greater than one day.Conclusions the parkinson's e-alert was found to a useful adjunct to existing hospital data systems in identifying pwp who have unplanned emergency attendances.Additionally, this system can also be employed as a service evaluation tool.However, further evaluation is needed to determine if this system can improve patient outcomes during their unplanned emergency attendance to hospital.

Journal: BMC health services research (2019)
Publication types: Journal Article
Adaptation and Testing of a Military Version of the Measure of Moral Distress for Healthcare Professionals.

Moral distress is well-documented among civilian critical care nurses and adversely affects patient outcomes, care delivery, and retention of health care providers.Despite its recognized significance, few studies have addressed moral distress in military critical care nurses.Objectives to refine and validate an instrument to assess moral distress in military critical care nurses.Methods this study examined moral distress in military critical care nurses (n = 245) using a new instrument, the measure of moral distress for healthcare professionals-military (mmd-hp-m).The psychometric properties of the refined scale were assessed by use of descriptive statistics, tests of reliability and validity, exploratory factor analysis, correlations, and qualitative analysis of open-ended responses.Results initial testing showed promising evidence of instrument performance.The cronbach α (0.94) suggested good internal consistency of the instrument for the overall sample.Scores for the mmd-hp items and the mmd-hp-m items showed a strong, significant correlation (α= 0.78, p < .001).Unique attributes of military nursing that contribute to moral distress included resource access, futile care, and austere conditions.Exploratory factor analysis established a new military-centric factor for question items associated with inadequate training for patient care, providing care in resource-limited settings, and personal exhaustion.Conclusions these results will help guide specific, targeted interventions to reduce the negative effects of moral distress on our military health care providers, especially in terms of readiness for the next global pandemic and retention of these invaluable personnel.

Journal: American journal of critical care : an official publication, American Association of Critical-Care Nurses (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.
Antibacterial Vancomycin@ZIF-8 Loaded PVA Nanofiber Membrane for Infected Bone Repair.

Bone substitutes with strong antibacterial properties and bone regeneration effects have an inherent potential in the treatment of severe bone tissue infections, such as osteomyelitis.In this study, vancomycin (van) was loaded into zeolitic imidazolate framework-8 (zif-8) to prepare composite particles, which is abbreviated as v@z.As a p h-responsive particle, zif-8 can be cleaved in the weak acid environment caused by bacterial infection to realize the effective release of drugs.Then, v@z was loaded into polyvinyl alcohol (pva) fiber by electrospinning to prepare pva/v@z composite bone filler.The drug-loading rate of v@z was about 6.735%.The membranes exhibited super hydrophilicity, water absorption and p h-controlled van release behavior.The properties of anti e.Coliand s.Aureuswere studied under the p h conditions of normal physiological tissues and infected tissues (p h 7.4 and p h 6.5, respectively).It was found that the material had good surface antibacterial adhesion and antibacterial property.The pva/v@z membrane had the more prominent bacteria-killing effect compared with the same amount of single antibacterial agent containing membrane such as zif-8 or van loaded pva, and the antibacterial rate was up to 99%.The electrospun membrane had good biocompatibility and can promote mc3t3-e1 cell spreading on it.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article
Intuitive eating and body appreciation in type 2 diabetes.

Our objective was to explore the socio-demographic, clinical, and nutritional factors of body appreciation in type 2 diabetics.This is a cross-sectional observational study with 179 adults and older adults (60 ± 10 years old).Most of the sample was female (n= 133; 74.3%).Through logistic regression analysis, it was observed that being perceived as overweight was associated with a 91.6% lower chance of being satisfied with one's body.Trusting hunger and satiety cues doubled the chances of body satisfaction.Thus, eating more intuitively, attending to the signs of hunger and satiety, is associated with greater body satisfaction in type 2 diabetics.

Journal: Journal of health psychology (2022)
Publication types: Journal Article;Observational Study;Research Support, Non-U.S. Gov't
Performance of the American Heart Association/American College of Cardiology/Heart Rhythm Society versus European Society of Cardiology guideline criteria for hospital admission of patients with syncope.

Current american college of cardiology/american heart association/heart rhythm society (acc/aha/hrs) and european society of cardiology (esc) guidelines recommend different strategies to avoid low-yield admissions in patients with syncope.Objective the purpose of this study was to directly compare the safety and efficacy of applying admission criteria of both guidelines to patients presenting with syncope to the emergency department in 2 multicenter studies.Methods the international basel ix (basel syncope eva luation) study (median age 71 years) and the u.s.Srs (improving syncope risk stratification in older adults) study (median age 72 years) were investigated.Primary endpoints were sensitivity/specificity for the adjudicated diagnosis of cardiac syncope (basel ix only) and 30-day major adverse cardiovascular events (30d-mace).Results among 2560 patients in the basel ix and 2085 in srs studies, acc/aha/hrs and esc criteria recommended admission for a comparable number of patients in basel ix (27% vs 28%), but acc/aha/hrs criteria less often in srs (19% vs 32%; p <.01).Recommendations were discordant in ∼25% of patients.In basel ix, sensitivity for cardiac syncope and 30d-mace among patients without admission criteria was comparable for acc/aha/hrs and esc criteria (64% vs 65%, p = .86; and 67% vs 71%, p = .15, respectively).In srs, sensitivity for 30d-mace was lower with acc/aha/hrs (54%) vs esc criteria (88%; p <.001).Similarly, specificity for cardiac syncope and 30d-mace in basel ix was comparable for both guidelines, but in srs the acc/aha/hrs guidelines showed a higher specificity for 30d-mace than the esc guidelines.Conclusion acc/aha/hrs and esc guidelines showed disagreement regarding admission for 1 in 4 patients and had only modest sensitivity, all indicating possible opportunities for improvements.

Journal: Heart rhythm (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Research Support, N.I.H., Extramural
Mn2+induced significant improvement and robust stability of radioluminescence in Cs3Cu2I5for high-performance nuclear battery.

Fluorescent type nuclear battery consisting of scintillator and photovoltaic device enables semipermanent power source for devices working under harsh circumstances without instant energy supply.In spite of the progress of device structure design, the development of scintillators is far behind.Here, a cs3cu2i5: mn scintillator showing a high light yield of ~67000 ph me v-1at 564 nm is presented.Doping and intrinsic features endow cs3cu2i5: mn with robust thermal stability and irradiation hardness that 71% or >95% of the initial radioluminescence intensity can be maintained in an ultra-broad temperature range of 77 k-433 k or after a total irradiation dose of 2590 gy, respectively.These superiorities allow the fabrication of efficient and stable nuclear batteries, which show an output improvement of 237% respect to the photovoltaic device without scintillator.Luminescence mechanisms including self-trapped exciton, energy transfer, and impact excitation are proposed for the anomalous dramatic radioluminescence improvement.This work will open a window for the fields of nuclear battery and radiography.

Journal: Nature communications (2021)
Publication types: Journal Article
Evaluation of two microcosm systems for co-treatment of LDPEoxoand lignocellulosic biomass for biochar production.

The co-transformation of solid waste of natural and anthropogenic origin can be carried out through solid-state-fermentation systems to obtain bio-products with higher added value and lower environmental impact.Methods to evaluate the effect of pleurotus ostreatus on co-transformation of oxo-degradable low-density polyethylene (ldpeoxo) sheets and lignocellulosic biomass (lcb), were assembled two 0.75 l microcosm systems in vertical (vms) and horizontal (hms) position.The pre-treated sheets with luminescent o2plasma discharges were mixed with pine bark, hydrolyzed brewer's yeast and paper napkin fragments and incubated for 135 days at 20 ± 1.0 °c in the presence of the fungus.With the co-transformation residues, biochar (bc) was produced at 300 ± 1.0 °c (bc300) for 1 h, then used to carry out adsorption studies, using the malachite green dye (mg) at p h 4.0, 7.0 and 9.0 ± 0.2.Finally, the biochar was the substrate for the germination of carnation seeds (dianthus caryophyllus) and ray-grass (lolium sp.) in vitro.Results for hms, the decrease in static contact angle (sca) was 63.63% (p = 0.00824) and for vms 74.45% (p = 0.00219), concerning the pristine.Plastic roughness in vms was higher (26%) concerning the control.Throughout the 135 days, there were fungal growth and consequently laccase (lac), manganese peroxidase (mn p) and lignin peroxidase (li p) activities.During the first 75 days, co2production increased to 4.78 ± 0.01 and 4.98 ± 0.01 mg g-1 for hms and vms, respectively.In mg adsorption studies, the highest amount of the colourant adsorbed at both p h 4.0 and 7.0 ± 0.2.Conclusions finally, the biochar or the biochar enriched with low concentrations of plant growth-promoting microorganisms and inorganic fertilizer favours the germination of dianthus caryophyllus and lolium sp., seeds.

Journal: Biomaterials research (2021)
Publication types: Journal Article
Point-of-Care Ultrasound Identifies Pyomyositis Secondary to Intramuscular Testosterone Injection: Report of Two Cases.

Intramuscular (i.m.) injections are a commonly utilized route for medication delivery.Intramuscular-associated soft tissue infections are rare and can include pyomyositis and i.m.Abscess.Intramuscular testosterone injections have not been previously implicated in causing pyomyositis.Point-of-care ultrasound is an important bedside tool that can identify pyomyositis and differentiate this infection from more common entities such as cellulitis.Case reports we present two cases of i.m.Testosterone-associated pyomyositis.In both cases, the physical examination features were consistent with simple cellulitis.However, point-of-care ultrasound evaluation revealed changes consistent with pyomyositis in each case.Why should an emergency physician be aware of this?: although uncommon, i.m.Injections such as testosterone carry a risk of soft tissue infection.As demonstrated in the above cases, ultrasound can be helpful in making the differentiation between simple cellulitis and pyomyositis.The emergency physician should be cognizant of this complication of therapeutic i.m.Injections, as well as the diagnostic efficacy of point-of-care ultrasound in evaluating the extent and location of the soft tissue infection.

Journal: The Journal of emergency medicine (2022)
Publication types: Case Reports;Journal Article
Development of an α-synuclein fibril and oligomer specific tracer for diagnosis of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.

The development of specific disease-associated pet tracers is one of the major challenges, the realization of which in neurodegenerative diseases would enable not only the efficiency of diagnosis but also support the development of disease-modifying therapeutics.Parkinson's disease (pd) is the most common neurodegenerative movement disorder and is characterized by neuronal fibrillary inclusions composed of aggregated α-synuclein (α-syn).However, these deposits are not only found in pd, but also in other related diseases such as multiple system atrophy (msa) and dementia with lewy bodies (dlb), which are grouped under the term synucleinopathies.In this study, we used ngs-guided phage display selection to identify short peptides that bind aggregated α-syn.By surface plasmon resonance (spr)-based affinity screening, we identified the peptide svlfib-5 that recognizes aggregated α-syn with high complex stability and sequence specificity.Further analysis spr showed that svlfib-5 is not only specific for aggregated α-syn, but in particular recognizes fibrillary and oligomeric structures.Moreover, fluorescence microscopy of human brain tissue sections from pd, msa, and dlb patients with svlfib-5 allowed specific recognition of α-syn and a clear discrimination between diseased and non-diseased samples.These findings provide the basis for the further development of an α-syn pet tracer for early diagnosis and monitoring of disease progression and therapy progress.

Journal: Neurochemistry international (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Genetic architecture in neonatal intensive care unit patients with congenital heart defects: a retrospective study from the China Neonatal Genomes Project.

Congenital heart defects (chds) are the most common type of birth defects.The genetic aetiology of chd is complex and incompletely understood.The overall distribution of genetic causes in patients with chd from neonatal intensive care units (nicus) needs to be studied.Methods chd cases were extracted from the china neonatal genomes project (2016-2021).Next-generation sequencing results and medical records were retrospectively evaluated to note the frequency of genetic diagnosis and the respective patient outcomes.Results in total, 1795 patients were included.The human phenotype ontology term of atrial septal defect, patent ductus arteriosus and ventricular septal defect account for a large portion of the chd subtype.Co-occurring extracardiac anomalies were observed in 35.1% of patients.269 of the cases received genetic diagnoses that could explain the phenotype of chds, including 172 copy number variations and 97 pathogenic variants.The detection rate of trio-whole-exome sequencing was higher than clinical exome sequencing (21.8% vs 14.5%, p<0.05).Further follow-up analysis showed the genetic diagnostic rate was higher in the deceased group than in the surviving group (29.0% vs 11.9%, p<0.05).Conclusion this is the largest cohort study to explore the genetic spectrum of patients with chd in the nicu in china.Our findings may benefit future work on improving genetic screening and counselling for nicu patients with chd.

Journal: Journal of medical genetics (2023)
Publication types: Journal Article;Research Support, Non-U.S. Gov't