syedzayyan/paper_mill_benchmark huggingface dataset:
DPPFit: Developing and Testing a Technology-Based Adaptation of the Diabetes Prevention Program (DPP) to Address Prediabetes in a Primary Care Setting.

The objective of this study was to adapt the national diabetes prevention program (n-dpp) into a pragmatic tool for primary care settings by using daily text messaging to deliver all n-dpp content, supplemented by fitbit technology to provide behavioral strategies typically delivered by personnel in traditional programs.Test the mobile health (m health), technology-based n-dpp adaptation (dppfit) in primary care patients with prediabetes using a remote intervention based on the traditional 16 core sessions of the dpp.Methods a pilot study with pre/post survey analysis of aggregate data were used to determine changes in weight, physical activity, sedentary behavior, and associated diabetes risk outcomes among study participants (n = 33).In this study, participants were issued fitbit devices and provided the remote intervention over 16 weeks via automated text messaging technology, which followed the content of the dpp core education sessions.Results data analysis from baseline to 6-month follow-up demonstrate mean weight loss of 3.3 kg (95% ci: -6.2 to -0.5;p=.026), reduction in body mass index by 1.25 points (95% ci: -2.1 to -0.4;p=.005), a significant average increase of 2 days in self-reported physical activity per week (95% ci: 0.4 to 3.6;p=.015) and an average 10% decrease in sedentary time (p=.007).Conclusions the remote dppfit intervention demonstrates a promising and practical approach to the management of prediabetes in a primary care setting.The results support the use of the dppfit program and application to achieve meaningful outcomes in a population with prediabetes.A randomized controlled trial with a larger sample is warranted.

Journal: Journal of the American Board of Family Medicine : JABFM (2022)
Publication types: Journal Article
Cumulative effects of cascade hydropower stations on total dissolved gas supersaturation.

Elevated levels of total dissolved gas (tdg) may occur downstream of dams during the spill process.These high levels would increase the incidence of gas bubble disease in fish and cause severe environmental impacts.With increasing numbers of cascade hydropower stations being built or planned, the cumulative effects of tdg supersaturation are becoming increasingly prominent.The tdg saturation distribution in the downstream reaches of the jinsha river was studied to investigate the cumulative effects of tdg supersaturation resulting from the cascade hydropower stations.A comparison of the effects of the joint operation and the single operation of two hydropower stations (xld and xjb) was performed to analyze the risk degree to fish posed by tdg supersaturation.The results showed that water with supersaturated tdg generated at the upstream cascade can be transported to the downstream power station, leading to cumulative tdg supersaturation effects.Compared with the single operation of xjb, the joint operation of both stations produced a much higher tdg saturation downstream of xjb, especially during the non-flood discharge period.Moreover, the duration of high tdg saturation and the lengths of the lethal and sub-lethal areas were much higher in the joint operation scenario, posing a greater threat to fish and severely damaging the environment.This work provides a scientific basis for strategies to reduce tdg supersaturation to the permissible level and minimize the potential risk of supersaturated tdg.

Journal: Environmental science and pollution research international (2018)
Publication types: Journal Article
Hydrogen bonding elements, π - hole functional moieties and C3v tripodal scaffold controlled turn-on cyanide and turn-off azide selective receptors.

Here in, we are reporting electron deficient amide and sulfonamide based tripodal receptors l, l1, l2and l3.Systematic studies show a strong selectivity towards cyanide and azide anions.Detailed uv-visible and fluorescent spectrometric investigation shows the amide based tripodal receptors l and l3acts as a colorimetric and turn-on fluorescent chemo-sensor for cyanide, and the sulfonamide based tripodal receptors l1and l2acts as a colorimetric and turn-off fluorescent chemo-sensor for azide.At the end we have successfully prepared tripodal receptors for a particular anion with judicious choice of recognition elements such as hydrogen bonding amide/sulfonamide moiety, electron deficient pentafluorophenyl functionality for anion-π interaction and the well defined c3v symmetric tripodal backbone for perfect recognition.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2019)
Publication types: Journal Article
Bacterial succession in oil-contaminated soil under phytoremediation with poplars.

Petroleum hydrocarbons (phcs) continue to be among the most common pollutants in soil worldwide.Phytoremediation has become a sustainable way of dealing with phc contamination.We conducted the off-site phytoremediation of phc-polluted soil from an oil tanker truck accident, where poplars were used for the phytoremediation of the oil-polluted soil in a boreal climate during a seven-year treatment.The succession of bacterial communities over the entire phytoremediation process was monitored using microbial ecological tools relying on high-throughput 16s r rna gene sequencing.Upon the successful depletion of phcs from soil, endophytic communities were analyzed in order to assess the complete plant-associated microbiome after the ecological recovery.The rhizosphere-associated soil exhibited different bacterial dynamics than unplanted soil, but both soils experienced succession of bacteria over time, with diversity being negatively correlated with phc concentration.In the relatively short growing season in north europe, seasonal variations in environmental conditions were identified that contributed to the dynamics of bacterial communities.Overall, our study proved that phytoremediation using poplar trees can be used to assist in the removal of phcs from soils in boreal climate conditions and provides new insight into the succession patterns of bacterial communities associated with these plants.

Journal: Chemosphere (2020)
Publication types: Journal Article
Clinical outcomes of 20 Japanese patients with insulinoma treated with diazoxide.

Diazoxide is recognized as an effective medical treatment for insulinoma.However, due to its adverse effects, such as fluid retention, it is sometimes difficult to employ diazoxide at an effective dose in clinical practice.This study aimed to clarify the clinical factors, which may affect efficacy and safety of the diazoxide treatment.We retrospectively evaluated the medical records of 20 patients with insulinoma including 4 malignant cases.The patients were divided into two groups according to the presence or absence of favorable outcomes or adverse effects, and the clinical features of both groups were compared.Diazoxide was effective and ineffective in each 9 patients, respectively.In other 2 cases, the efficacy could not be determined.In the effective group, all patients had benign insulinoma.Additionally, the tumor size determined by imaging test was tended to smaller than the ineffective group but not statistically significant when malignant cases were excluded (p = 0.065).Fluid retention was observed more frequently in females than in males (p = 0.025).Five patients displayed unacceptable thrombocytopenia within a few weeks after the administration of diazoxide.In these patients, the diazoxide dose was significantly higher than that in the other patients [400 mg/day (250-500 mg/day) vs.225 mg/day (50-425 mg/day), p = 0.027].These findings may be informative in determining the indication and dose of diazoxide against insulinoma.In addition, a careful evaluation of platelet count would be required for a few weeks after the initiation of diazoxide treatment.

Journal: Endocrine journal (2019)
Publication types: Journal Article
Arsenolipids reduce butyrate levels and influence human gut microbiota in a donor-dependent way.

Arsenolipids are organic arsenic species with variable toxicity.Accurate assessment of the risks derived from arsenic-contaminated seafood intake requires studying the interplay between arsenolipids and the human gut microbiota.This research used the in vitro mucosal simulator of the human intestinal microbial ecosystem (m-shime) to assess the effect of defined chemical standards of arsenolipids (as fa 362 and as hc 332) on a simulated healthy human gut microbiota (n = 4).Microbial-derived metabolites were quantified by gas chromatography and microbiota structure was characterized by 16s r rna gene sequencing.A specific reduction in butyrate production (control=5.28 ± 0.3 m m; as fas=4.56 ± 0.4 m m; as hc 332=4.4 ± 0.6 m m, n = 4 donors), concomitant with a reduction in the abundance of lachnospiraceae ucg-004 group and the faecalibacterium genus was observed, albeit in a donor-dependent manner.Furthermore, an increase in escherichia/shigella, proteobacteria and fusobacterium abundance was observed after arsenolipid treatments, depending on individual microbiota background.These alterations in microbial functionality and microbial community structure suggest a detrimental effect of arsenolipids intake towards the commensal gut microbiome, and consequently, on human health.

Journal: Ecotoxicology and environmental safety (2022)
Publication types: Journal Article
Prenatal diagnosis of mosaic trisomy 8 by amniocentesis in a fetus with ventriculomegaly and dysgenesis of the corpus callosum.

We present prenatal diagnosis of mosaic trisomy 8 by amniocentesis in a fetus with central nervous system abnormalities.Case report a 39-year-old woman was found to have fetal bilateral ventriculomegaly and enlargement of the third ventricle on prenatal ultrasound at 32 weeks of gestation.Fetal magnetic resonance imaging examination confirmed bilateral ventriculomegaly and dysgenesis of the corpus callosum.Amniocentesis was performed subsequently.Array comparative genomic hybridization (a cgh) analysis on the dna extracted from uncultured amniotic cells revealed trisomy 8 mosaicism with a result of arr [grch37] (8) × 3[0.19], (x,y) × 1.Conventional cytogenetic analysis on cultured amniocytes showed that among 108 cells in 12 colonies of three cultures, only one cell was abnormal with trisomy 8, trisomy 9 and monosomy 13, while the rest 107 cells had a normal karyotype.Repeat amniocentesis and cord blood sampling revealed a result of arr 8p23.3q24.3 (191,530-146,280,020) × 2.3 with a log2ratio of 0.2 compatible with 20-30% mosaicism for trisomy 8 on the uncultured amniocytes, and a result of arr 8p23.3q24.3 (191,530-146,280,020) × 2.1 with a log2ratio of 0.08 compatible with <10% mosaicism for trisomy 8 on the cord blood lymphocytes.Polymorphic dna marker analysis excluded uniparental disomy 8.A malformed 2440-g dead fetus was delivered at 34 weeks of gestation with facial dysmorphism.Conclusion cytogenetic discrepancy can occur between cultured and uncultured amniocytes in mosaic trisomy 8 at amniocentesis.A cgh analysis on uncultured amniocytes is useful for confirmation of mosaic trisomy 8 at amniocentesis.Fetuses with low-level mosaicism for trisomy 8 may prenatally present ventriculomegaly and dysgenesis of the corpus callosum.

Journal: Taiwanese journal of obstetrics & gynecology (2020)
Publication types: Case Reports;Journal Article
Hemicyanine based naked-eye ratiometric fluorescent probe for monitoring lysosomal pH and its application.

Lysosome as the typical acidic organelle involved in many biological processes, the dysfunction of its p h would alter many diseases.Small-molecule fluorescent probe has been considered as vital tool for monitoring p h fluctuation in living cells.Herein, a hemicyanine based ratiometric fluorescent probe was synthesized, namely, 2,3-trimethy-3-[2-(dimethyl-amino-4-yl) vinyl]-3h-benzo[e]indole (bi dl), for rapidly detection p h under acidic conditions.Bi dl exhibited ratio fluorescence emission (f534nm/f622nm) characteristic with p ka4.25.Bi dl showed good linearly response in p h 3.4-4.82, indicating that the probe can be used for quantitative detection p h.The probe also displayed large stokes shift (112 nm/201 nm) under neutral and acidic conditions, respectively, which could effectively reduce the excitation interference.Bi dl had excellent cell membrane permeability, good photo-stability and low toxicity in living cells.The dual-channel confocal fluorescent microscopic ratiometric imaging application of p h in he la cells and lysosome were achieved successfully, indicating that bi dl has good potential for investigating lysosome-relevant pathological and physiological processes.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2020)
Publication types: Journal Article
Hormonal profile in early luteal phase after triggering ovulation with gonadotropin-releasing hormone agonist in high-responder patients.

The major limitations associated with gonadotropin-releasing hormone agonist (gn rha) triggering are inferior clinical outcomes in fresh embryo transfer cycles caused by luteal phase insufficiency following the gn rha triggering.We included 153 high-risk patients in this study.In group i, the patients received gonadotropin-releasing hormone agonist (gn rha) trigger + 1,500 iu human chorionic gonadotropin (h cg) support on the oocyte pick-up (opu) day; in group ii, the patients had a dual trigger (gn rha + 1,500 iu h cg); and in group iii (control), 10,000 iu h cg trigger was prescribed for the final oocyte maturation.The levels of lh, estradiol, and progesterone were evaluated in serum on the stimulation starting day, day 6 of stimulation, on the day of the trigger administration, opu day, days 3 and 5 post-opu, and day 14 post-et, as well as in follicular fluid.Progesterone concentration was significantly lower in group i on opu+5 compared to the h cg group (i vs.Iii, р = 0.0065).Progesterone levels were significantly lower in group ii in serum on opu+5 compared to groups i and iii (i vs.Ii,р= 0.0068; ii vs.Iii,р= 1.76 × 108).The progesterone levels were significantly higher in follicular fluid in group iii compared to the study groups (i vs.Iii,р= 0.002; ii vs.Iii,p= 0.009).However, no significant differences in clinical outcomes were found between the groups.Then, we divided all women into pregnant and non-pregnant groups and found that estradiol (p= 0.00009) and progesterone (p= 0.000036)on the day of the pregnancy test were significantly higher in the pregnant women group.Also, progesterone on opu day was significantly higher in the non-pregnant group (p= 0.033).Two cases of moderate ovarian hyperstimulation syndrome (ohss) late-onset occurred in group i (3.5%, 2/56), no case of moderate/severe ohss late-onset in group ii, and three cases of moderate late-onset in group iii (5.7%, 3/53).The low-dose h cg supplementation improves the luteal phase insufficiency after gn rha triggering, which is confirmed by the comparable pregnancy rates in fresh transfer cycles between the groups.However, low-dose h cg carries a similar risk of ohss as the full dose of h cg in high-responder patients.

Journal: Frontiers in endocrinology (2022)
Publication types: Journal Article
Multiscaled causality of infections on viral testing volumes: The case of COVID-19 in Tunisia.

S coronavirus disease (covid-19) is one of the most detrimental pandemics that affected the humanity throughout the ages.The irregular historical progression of the virus over the first year of the pandemic was accompanied with far-reaching health and social damages.To prepare logistically against this worsening disaster, many public authorities around the world had set up screening and forecasting studies.This article aims to analyse the time-frequency co-evolution of the number of confirmed cases (ncc) in tunisia and the related number of performed polymerase chain reaction (pcr) tests over the covid-19 first year.Accurately predicting such a relationship allows tunisian authorities to set up an effective health prevention plan.Study design in order to keep pace with the speed of evolution of the virus, we used uninterrupted daily time series from the tunisian ministry of public health (tmph) recorded over the covid-19 first year.The objective is to: (1) analyse the time-frequency progress of the ncc in relationship with the number of pcr tests, (2) identify a multi-scale two-factor stochastic model in order to develop a robust bivariate forecasting technique.Methods we assume a bivariate stochastic process which is projected onto a set of wavelet sub-spaces to investigate the scale-by-scale co-evolvement the ncc/pcr over the covid-19 first year.A wavelet-based multiresolutional causality test is then performed.Results the main results recommend the rejection of the null hypothesis of no instantaneous causality in both directions, while the statistics of the granger test suggest failing to reject the null hypothesis of non-causality.However, by proceeding scale-by-scale, the granger causality is proven significant in both directions over varying frequency bands.Conclusions it is important to include the ncc and pcr variables in any time series model intended to predict one of these variables.Such a bivariate and multi-scale model is supposed to better predict the needs of the public health sector in screening tests.On this basis, testing campaigns with multiple periodicities can be planned by the tunisian authorities.

Journal: The International journal of health planning and management (2022)
Publication types: Journal Article
Local and systemic immune responses to different types of phytohemagglutinin in the green anole: Lessons for field ecoimmunologists.

The phytohemagglutinin (pha) skin test is commonly used by ecologists to assess cell-mediated immune function of wild animals.It can be performed quickly and easily in the field, involving injection of pha and measurement of the resultant swelling.There are multiple formulations of pha used in ecological studies, with potentially differing outcomes that could produce inconsistent results.We tested two common types of pha in the green anole (anolis carolinensis) to identify local and systemic immune responses underlying the resultant swelling at 6, 18, 24, and 48 hr post injection.There were differences in both local (injection site) and systemic (blood) leukocyte responses to pha-l versus pha-p.Pha-p injection produced a greater overall increase in local heterophil count at the injection site compared with pha-l, and this response was greatest at 6 and 24 hr post injection.Systemically, heterophil percentage was higher in the blood of pha-p- versus pha-l-injected anoles at 24 hr post injection; the time point at which heterophil percentage peaked in pha-p-injected anoles.These results indicate that although both pha types are effective tests of immune function in green anoles, the pha-p swelling response invokes a much stronger heterophilic response.Pha-l is a more specific test of lymphocyte function, particularly at 24 hr post injection, making it preferable for ecoimmunology studies.

Journal: Journal of experimental zoology. Part A, Ecological and integrative physiology (2017)
Publication types: Journal Article
Machine learning-aided risk prediction for metabolic syndrome based on 3 years study.

Metabolic syndrome (met s) is a group of physiological states of metabolic disorders, which may increase the risk of diabetes, cardiovascular and other diseases.Therefore, it is of great significance to predict the onset of met s and the corresponding risk factors.In this study, we investigate the risk prediction for met s using a data set of 67,730 samples with physical examination records of three consecutive years provided by the department of health management, nanfang hospital, southern medical university, p.r.China.Specifically, the prediction for met s takes the numerical features of examination records as well as the differential features by using the examination records over the past two consecutive years, namely, the differential numerical feature (dnf) and the differential state feature (dsf), and the risk factors of the above features w.r.t different ages and genders are statistically analyzed.From numerical results, it is shown that the proposed dsf in addition to the numerical feature of examination records, significantly contributes to the risk prediction of met s.Additionally, the proposed scheme, by using the proposed features, yields a superior performance to the state-of-the-art met s prediction model, which provides the potential of effective prescreening the occurrence of met s.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Validation Study
Self-Perceived ADL/IADL Function is Influenced by Residual Neurological Impairment, Aphasia, and Anxiety.

Self-perceptions of performance of activities of daily living (adl) and instrumental activities of daily living (iadl) are reduced following stroke.Research investigating contributing factors is lacking.purpose:we examined the extent to which aphasia status, neurological impairment and poststroke depression, and anxiety contribute to self-perceived adl/iadl function.method:seventy-six community-dwelling individuals at least 6 months poststroke, 44 with and 32 without aphasia, participated in the cross-sectional study.The stroke impact scale (sis) adl/iadl domain was the primary outcome measure with aphasia status, residual neurological impairment, depressive symptoms, and anxiety as predictor variables.findings:aphasia status, residual neurological impairment, and anxiety were independent predictors of self-perceived adl/iadl function, together accounting for more than half the variance.Depression was not associated with adl/iadl.implications:clinician awareness of the influence of anxiety on self-perceived adl/iadl function, particularly for people with aphasia, may lead to future interventions that improve self-perceived adl/iadl function.

Journal: Canadian journal of occupational therapy. Revue canadienne d'ergotherapie (2022)
Publication types: Journal Article