syedzayyan/paper_mill_benchmark huggingface dataset:
The Awareness of the Human Papillomavirus Infection and Oropharyngeal Cancer in People to Improve the Health Care System at Al Qunfudhah Region, Kingdom of Saudi Arabia

With 14 million new infections each year, the human papillomavirus (hpv) is the most common sexually transmitted infection (sti) among both men and women in the united states (us).Infections with the human papillomavirus (hpv) are responsible for a considerable portion of the global cancer burden.Hpv-related oral malignancies are on the rise around the world, according to epidemiological studies.To provide accurate advice to their patients, dental practitioners require thorough, up-to-date hpv-related knowledge.Methods.In this cross-sectional study, data were collected by the purposely constructed questionnaire.A questionnaire composed of the demographic items and items related to the awareness and knowledge about human papillomavirus.The questionnaire was constructed after a series of discussions between the panel of experts.This panel was composed of a subject specialist, researcher, and language expert.The cronbach alpha of the questionnaire was calculated.The study will be conducted in the al qunfudhah.Results.The cronbach alpha of the questionnaire was 0.72.Out of a total of 550 respondents, with a mean (sd) age of 47.5 (11.5), the female respondents were 167 (30.4%) while male were 383 (69.6%).20.5% of the respondents (out of 550) were having awareness of hpv.Implications.Knowledge of hpv-related oral cancer is critical, and it is advised to be taught as part of dental students’ basic curriculum and clinical training.This problem can be solved by better educational training programs.Knowledge of hpv-related oral cancer is critical, and it is advised to be taught as part of dental students’ basic curriculum and clinical training.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
The Effective Components, Core Targets, and Key Pathways of Ginseng against Alzheimer’s Disease

Panax ginseng c.A.Mey ( ginseng ) is a traditional chinese medicinal herb used for the treatment of nervous system disorders, such as alzheimer’s disease (ad).However, the pharmacological mechanisms of ginseng involved in ad have not been systematically investigated.Here, a network pharmacology approach was adopted to explore the effective components, core targets, and key pathways of ginseng against ad.Methods .Tcmsp database was used to screen the active ingredients of ginseng .Prediction of the targets of ginseng and ad‐related genes was performed using online public databases.“compound‐target,” “compound‐target‐disease,” “protein‐protein interaction (ppi),” “compound‐target‐pathway,” and “compound‐target‐go–pathway” networks were constructed with cytoscape 3.7.2 software.Gene ontology (go) function annotation and kyoto encyclopedia of genes and genomes (kegg) pathway enrichment were performed by using the david database.Results .A total of 22 bioactive compounds were identified from ginseng , and 481 targets of ginseng and 763 ad‐related targets were obtained from public databases.The ppi network screened out 19 hub genes of ginseng against ad.According to go function enrichment, ginseng influenced cell proliferation, death, the nitric oxide biosynthetic process, hypoxia response, and synaptic transmission.Neuroactive ligand‐receptor interaction, serotonergic synapse, calcium signaling, c amp signaling, fox o signaling, ras signaling, and pi3k‐akt signaling were among the most key regulatory pathways.The compound‐target‐go‐route network found egfr, mapk1, mapk14, akt1, casp3, and prkaca as key genes, with pi3k‐akt signaling being the most important pathway for ginseng’s anti‐ad activity.Conclusion .Ginseng exerts neuroprotective effects in ad patients through multicomponent, multitarget, and multipathway modes, providing novel insight into the pharmacological and experimental research on ginseng against ad.

Journal: Evidence-Based Complementary and Alternative Medicine (2023)
Publication types: Research Article;
The Influence of Hong Kong-Zhuhai-Macao Bridge on the Development of Urban Agglomeration in the Pearl River Delta

Known as one of the “seven wonders of the modern world”, the hong kong-zhuhai-macao bridge connects hong kong, zhuhai, and macao.The bridge, which lasted 14 years from design to construction, spans the lingdingyang waters of the south china sea to the west, connects macao and zhuhai artificial islands, and ends at zhuhai hongwan.The bridge, which shortens the traffic distance between the three places and allows the economy, culture, and technology of the three places to communicate with each other, opened up a new world.This paper intends to review the process of the construction of the hong kong-zhuhai-macao bridge and sort out the expected benefits of the bridge’s opening to traffic.Then, the paper explains the new situation faced by the hong kong-zhuhai-macao bridge.Based on the outward service function model of city flow and the interaction strength model, we conduct an empirical study on the economic status of the guangdong-hong kong-macao greater bay area.This paper analyzes the interaction between the cities which are in the greater bay area and uses panel data to conduct regression analysis to verify the important impact of the hong kong-zhuhai-macao bridge on the development of cities in the pearl river delta.Finally, conclusions are drawn: hong kong-zhuhai-macao bridge is undoubtedly of positive significance to strengthen economic and social ties between the west bank of the pearl river and hong kong, and hong kong has a large economic radiation capacity to the cities that are in the pearl river delta and macao in the construction, finance, transportation, warehousing, and communications industries.And corresponding suggestions are put forward.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
The Association between Long Noncoding RNA over Expression and Poor Prognosis of Liver Cancer: A Meta-Analysis

Long noncoding rna (lnc rna) is considered to be a mediator of carcinogenesis, which may be associated with liver cancer survival.However, the relationship remains inconclusive.Meta-analysis was conducted to analytically review the association between the lnc rna expression level and clinicopathological characteristics and prognostic value of hepatic carcinoma.Materials and methods.Four databases including embase, pub med, web of science, and the cochrane library were searched to collect studies about the relation between lnc rna overexpression and prognosis of liver cancer, dating from the earliest records of these databases to march 2021.Two researchers independently screened the data and literature to perform a stringent evaluation of the quality of material involved in the study.Meta-analysis was performed by stata 16.0 software on 42 case-control studies with 6293 samples.Results.The outcomes of meta-analysis are presented as follows: lnc rna overexpression patients had later tnm stage (or = 0.36, 95% ci (0.31, 0.41), p &lt; 0.001), lower histological grade (or = 0.56, 95%ci (0.49, 0.65), p &lt; 0.001), more vascular invasion (or = 2.02, 95% ci (1.74, 2.35), p &lt; 0.001), bigger tumor size (or = 2.28, 95% ci (2.00, 2.60), p &lt; 0.001), more severe liver cirrhosis (or = 1.39, 95% ci(0.1.16, 1.66), p &lt; 0.001), more likely to metastasize (or = 1.80, 95%ci(1.49, 2.18), p &lt; 0.001), and more tumor numbers (or = 0.72, 95% ci (0.62, 0.84), p &lt; 0.05).Lnc rna over expression patients had shorter os (hr = 2.32, 95 ci% (2.08, 2.59), p &lt; 0.01, rfs (hr = 2.19, 95 ci% (1.72, 2.78), p &lt; 0.01), and dfs (hr = 2.01, 95 ci% (1.57, 2.57), p &lt; 0.01).Conclusions.Overexposure of lnc rna is a poor prognostic feature for patients with hepatic carcinoma.The scope of our study was limited because of a lack of relevant research and the poor representativeness and varying quality of the studies involved in the current meta-analysis.Our conclusion still requires higher studies for further validation.This trial is clinically registered with crd4201920620.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Meta-Analysis;
The Application Value of CT Three-Dimensional Microscope Reconstruction Technology in the Diagnosis of Cervical Cancer

In order to study the application value of ct three-dimensional microscope reconstruction technology in the diagnosis of cervical cancer.In this paper, 232 patients with newly diagnosed stage ia-ii a2 and some stage iii c: cervical cancer (stage ib1-iia2 of stage f go in 2009) were selected, and 204 patients with stage ib1-iia2 of stage 2009 fig 0 were selected.The original data of dicom were obtained by ct scanning and imported into mics10.01 software to complete lymph node reconstruction.The short diameter value &gt; 10 mm is used as the standard to judge whether the lymph node is metastatic.Referring to the 2018fig 0 staging standard, if it indicates that the lymph node is positive, it is iiicr stage.The gold standard is the diagnosis of iii cp according to the surgical and pathological results, and then the diagnostic efficiency of iii c stage is evaluated.The experimental results showed that 65 cases were diagnosed as iiic stage, and 70 cases were diagnosed as iiicp stage.There was consistency between iiicr and iiicp stage, and the kappa value was 0.340.Using ct multiphase enhanced scanning and three-dimensional reconstruction technology to diagnose cervical cancer has high detection rate and high accuracy of staging diagnosis, which is worthy of clinical application.

Journal: Scanning (2022)
Publication types: Research Article;
The Application of Ultrasound Image in Cancer Diagnosis

In order to solve the problem of low accuracy, high cost, and difficult detection of traditional algorithms, a new algorithm based on ultrasound imaging is proposed in this paper.The algorithm is based on fuzzy clustering to diagnose the disease and effectively improve the accuracy of the algorithm.By testing the actual scene, it effectively proves the effectiveness and accuracy of the algorithm, which can find and treat diseases in time and can be widely used and popularized in clinical research in china.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
TC-PSLAP: Temporal Credential-Based Provably Secure and Lightweight Authentication Protocol for IoT-Enabled Drone Environments

In smart cities, common infrastructures are merged and integrated with various components of information communication and technology (ict) to be coordinated and controlled.Drones (unmanned aerial vehicles) are amongst those components, and when coordinated with each other and with the environment, the drones form an internet of drones (io d).The io d provides real-time data to the users in smart cities by utilizing traditional cellular networks.However, the delicate data gathered by drones are subject to many security threats and give rise to numerous privacy and security issues.A robust and secure authentication scheme is required to allow drones and users to authenticate and establish a session key.In this article, we proposed a provably secure symmetric-key and temporal credential-based lightweight authentication protocol (tc-pslap) to secure the drone communication.We prove that the proposed scheme is provably secure formally through the automated verification tool avispa and burrows–abadi–needham logic (ban logic).Informal security analysis is also performed to depict that the proposed tc-pslap can resist known attacks.

Journal: Security and Communication Networks (2021)
Publication types: Research Article;
Taxi Dispatch Optimization in Smart Cities Using TOPSIS

The modern smart cities demand an efficient taxi dispatch system to satisfy the expectations of the passengers while giving justified rides to the drivers.Many a time, the customers have to wait too long for a taxi and the taxi driver wastes a lot of his time and the fuel in finding customers.Furthermore, some customers cancel the ride for not finding suitable category of taxi.Though there exist some algorithms that aim to optimize the assignment of taxis to appropriate customers, yet most of these approaches focus on the positioning of the taxi drivers.This research aims to address the problem of taxi dispatching while keeping in view the preferences of the customer.To this end, this research models taxi dispatch system as a multicriteria decision-making problem where not only is the distance between the passenger and the taxi a parameter, but other user preferences are also incorporated in finalizing a taxi for a given passenger travel request.The proposed method has been compared with the traditional taxi dispatching system.The results reveal more satisfactory taxi dispatching based on the users’ preferences.Furthermore, the precision of the proposed approach has been proven with lesser cancellation, improved driver rating, and reduction in complaints.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Systematic Review and Meta-Analysis on the Rehabilitation Effect of Different Intensity Exercise on the Patients with Cardiovascular Diseases

Cardiovascular disease is a common disease with high prevalence, disability, and mortality.Exercise therapy can improve cardiac functional reserve and life quality of patients, but the benefits of different exercise intensities for cardiovascular patients are still controversial.In this study, literature search and meta-analysis were used to explore the effect of 2 intensities of exercise on the rehabilitation effect of cardiovascular patients.Methods.We searched embase, wiley online library, pub med, science direct, and clinicaltrials to look for randomized controlled trial (rct) studies of high-intensity interval training (hiit) versus moderate continuous training (mct).After screening the inclusion criteria for the literature and assessing the risk of bias, a software analysis was performed using the r language toolkit to obtain forest plots and funnel maps.Results.10 articles were included in this study into the quantitative analysis, and 520 patients participated in the study; meta-analysis results showed that after hiit intervention, the vo2 peak index of patients was higher than that of the mct group ( md = 1.39 , 95% ci (0.10, 2.68), z = 2.12 , p = 0.0344 ), the peak heart rate hr peak was higher than that of the mct training ( md = 7.71 , 95% ci (5.12, 10.30), z = 5.84 , p &lt; 0.0001 ), the respiratory exchange rate (maximum rer) was higher than that of the mct training ( md = 0.02 , 95% ci (0.00, 0.04), z = 2.36 , p = 0.0184 ), and the quality of life was higher than that of the mct training ( md = 0.39 , 95% ci (0.07, 0.71), z = 2.40 , p = 0.0165 ).Discussion.Compared with moderate continuous training, high intensity interval training is more conducive to improve the cardiopulmonary function of cardiovascular patients and improve their physical life quality.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Meta-Analysis;
Sulforaphane Ameliorates Limb Ischemia/Reperfusion-Induced Muscular Injury in Mice by Inhibiting Pyroptosis and Autophagy via the Nrf2-ARE Pathway

Limb ischemia/reperfusion (i/r) injury, as a life-threatening syndrome, is commonly caused by skeletal muscle damage resulting from oxidative stress.Additionally, inflammation-induced pyroptosis and dysregulated autophagy are vital factors contributing to the aggravation of i/r injury.Of note, sulforaphane (sfn) is a natural antioxidant, but whether it worked in limb i/r injury and the possible mechanism behind its protection for skeletal muscle has not been clearly established.Methods.Effects of sfn on limb i/r-injured skeletal muscle were assessed by he staining, followed by assessment of wet weight/dry weight (w/d) ratio of muscle tissues.Next, elisa and biochemical tests were used to measure the inflammatory cytokine production and oxidative stress.Immunofluorescent analysis and western blot were adopted to examine the level of pyroptosis- and autophagy-related proteins in vivo.Moreover, protein levels of nrf2-are pathway-related factors were also examined using western blot.Results.Sfn treatment could protect skeletal muscle against limb i/r injury, as evidenced by diminished inflammation, pyroptosis, autophagy, and oxidative stress in skeletal muscles of mice.Further mechanistic exploration confirmed that antioxidative protection of sfn was associated with the nrf2-are pathway activation.Conclusions.Sfn activates the nrf2-are pathway, and thereby inhibits pyroptosis and autophagy and provides a novel therapeutic strategy for the limb i/r-induced muscle tissue damage.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Subretinal Drusenoid Deposits and Lower Serum High-Density Lipoprotein Cholesterol Levels Possess Latent Relation to Cardiovascular Disease and Can Be a Feasible Predictor

To ascertain whether lipid-related subretinal drusenoid deposits (sdd) are correlated with coexisting cardiovascular disease (cvd), as well as to reveal latent serum markers of cvd.Methods.Patients older than 50 years and plagued by age-related macular degeneration (amd) were included.Subjects with other retinal degenerations and vascular diseases, any recent treatment at other medical care institutions, and any previous oculopathy or ophthalmic surgery were excluded.All subjects were examined to ascertain whether they possess sdd, to analyze serum cholesterols, including low-density lipoprotein cholesterol (ldl), triglycerides (tg), high-density lipoprotein cholesterol (hdl), and total cholesterol (tc).Subjects were divided into sdd and non-sdd groups and further divided into subgroups by assessment of pump defect, valve defect, and carotid defect.Finally, logistic model trees and random forest algorithm analysis were performed.Results.A total of 85 amd patients including 43 with and 42 without sdd were involved.The 42 amd (97.67%, 42/43) patients with sdd showed cvd, including 3 subjects presenting valve defect, 3 subjects presenting carotid defect, 8 subjects presenting pump defect, 14 subjects presenting both pump and valve defects, and 14 subjects presenting pump, valve, and carotid defects.By contrast, 5 amd (11.90%, 5/42) patients without sdd showed cvd.Cholesterol level of sdd subjects presented significant higher tc ( 5.66 ± 1.01 vs.5.58 ± 0.72 , p = 0.032 , wilcoxon test) and lower hdl cholesterol ( 61 ± 17 vs.70 ± 21 , p = 0.031 , wilcoxon test) than that of non-sdd.The cases with hdl &lt; 62 mg / d l were significantly related to cvd ( p = 0.013 , wilcoxon test), and the cases with hdl &lt; 40 mg / d l were not ( p = 0.659 , wilcoxon test).Through machine learning based on the image from color fundus photography, the accuracy of predicting cvd was 95%.Conclusions.The presence of sdd of amd and lower serum hdl cholesterol level can predict certain cvd for amd patients.The machine learning based on the sdd image and serum hdl cholesterol may open new avenue for the detection of cvd as a noninvasive approach.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Study on the Relationship between lncRNA Gene Polymorphism and Systemic Lupus Erythematosus

Systemic lupus erythematosus (sle) is an autoimmune disease that can cause damage to multiple systems of the body.A number of studies have shown that long-chain noncoding rna (lnc rna) can participate in the occurrence and development of a variety of autoimmune diseases.This study is aimed at detecting the expression levels of 5 lnc rnas in sle patients and healthy controls and at exploring the relationship between expression levels and clinical symptoms and laboratory indicators.Methods.The design type of this study is a case-control study.A total of 76 sle patients and 71 healthy controls were included in the first phase of the study.Real-time fluorescence quantitative polymerase chain reaction was used to detect the expression level of 5 kinds of lnc rnas including lnc7514, lnc0640, lncagf, nc3643, and lnc5150 in pbmcs of two groups of patients; the expression of lnc rnas in the case group and the control group was analyzed.We analyzed the differences in the expression levels of lnc rnas between case and control groups, and explored the association of expression levels with clinical manifestations and laboratory characteristics.Spss23.0 was used to analyze the expression level and gene polymorphism results; the statistical analysis test level α = 0.05 .Results.The expression level of lnc0640 in pbmcs of sle patient group was higher than that of healthy control group ( z = − 3.56 , p = 0.03 ).However, lnc5150 was lower than in healthy controls ( z = − 7.16 , p &lt; 0.001 ).Lnc3643 expression levels were lower in sle patients of sle patients with pleurisy was lower than that of patients without pleurisy ( z = − 2.44 , p = 0.02 ).Low lnc3643 expression levels were observed in pbmcs with sle patients with rash symptoms ( z = − 2.75 , p = 0.013 ).Sle expressed lower lnc3643 levels in pbmcs with sle compared with those without pleurisy ( z = − 2.42 , p = 0.02 ).The above differences were statistically significant.Association analysis of lnc rna expression levels and clinical manifestations in sle patients found that sle was lower than those without rash or pleurisy (both p &lt; 0.05 ); association analysis of lnc rna expression level and laboratory results found a negative correlation between lnc3643, lnc7514, and sle disease activity score (sledai-2k), blood sink (esr), and c-reactive protein (crp) (all p &lt; 0.05 ).Conclusions.Lnc0640 was overexpressed in pbmcs in sle patients compared with healthy controls.Lnc3643 was negatively correlated with sledai, and expression levels were associated with sle patients with arthritis, rash, and pleuritis.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Study on the Effect of Prehospital Emergency Nursing Model Based on Network Information Sharing Platform in Acute Ischemic Stroke

Acute ischemic stroke is one of the most common emergencies in clinical medicine.Prehospital first aid of ischemic stroke has become the focus and focus of the global medical community.The combination of network information technology and prehospital first aid can better serve the treatment of ischemic stroke.Objective.To explore the effect of prehospital emergency nursing model based on network information sharing platform in acute ischemic stroke.Methods.78 patients with acute ischemic stroke from february 2020 to october 2021 were studied.Patients were randomly divided into study group ( n = 39 ) and control group ( n = 39 ).The control group was given routine first aid nursing.Prehospital first aid nursing based on network information sharing platform was used in the study group.Alarm response time, on-site first aid response time, hospital handover time, national institutes of health stroke scale (nihss) at 12 and 24 hours after admission, glasgow coma scale (gcs) at 12 and 24 hours after admission, incidence of poor prognosis, and nursing satisfaction score at 24 hours after admission were recorded.Results.The emergency response time and hospital handover time in the study group were significantly shorter than those in the control group ( p &lt; 0.05 ).The nihss score and the incidence of poor prognosis at 12 and 24 hours after admission in the study group were lower than those in the control group ( p &lt; 0.05 ).The gcs scores at 12 hours and 24 hours after admission in the study group were higher than those in the control group ( p &lt; 0.05 ).The nsns score of the study group was higher than that of the control group.Conclusion.Prehospital first aid nursing based on network information sharing platform has great application value in patients with acute ischemic stroke.It can shorten the time of first aid, improve patients’ consciousness, and reduce the incidence of poor prognosis.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;