syedzayyan/paper_mill_benchmark huggingface dataset:
Source contributions and drivers of physiological and psychophysical cobenefits from major air pollution control actions in North China.

North china is among the most polluted regions in the country, and human exposure to pm2.5(particulate matter with an aerodynamic diameter less than 2.5 μm) in this region has led to severe health consequences.The region has also benefited the most from emission reductions in recent years.It is of interest to understand to what extent and through which paths emissions from different sectors cause adverse health impacts.Here, we present the results of a full evaluation of the health benefits of emission control actions implemented in recent years based on segregated emission inventories with an emphasis on residential emissions.Two major causal paths, one from residential emissions to indoor air pollution, exposure, and premature deaths, and the other from nonresidential emissions to ambient air pollution and psychophysical impacts, were identified and quantified.From 2014 to 2019, both ambient (33%) and indoor (39%) pm2.5decreased significantly, leading to decreasing trends in exposure (36%), premature deaths (10%), and psychophysical impacts (21%).The air pollution prevention and control action plan, the clean heating campaign, and spontaneous residential shifts to clean energy contributed significantly to these reductions when the effects of other drivers, such as population and economic growth, were excluded.

Journal: Environmental science & technology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Isolation and identification of new source of bacteriocin-producing Lactobacillus plantarum C010 and growth kinetics of its batch fermentation.

The control of food-borne pathogens and spoilage organisms in meat and related products is urgently needed.Bacteriocins produced by lactic acid bacteria (lab) are promising natural food preservatives.In this study, six bacteriocin-producing bacteria were screened from soil and fresh cow dung.Pseudomonas koreensis ps1, a specific spoilage organism from spoiled chilled pork, was used as the indicator bacteria.From the analyses, the strain c010 was selected due to its high yield, broad spectrum, and subculture stability.Through morphological, biochemical, and 16s r dna gene sequence analysis, this strain was identified as lactobacillus plantarum.Crude bacteriocin extracted from the cell-free supernatant (cfs) of l.Plantarum c010 was stable under high temperature, ultraviolet radiation, and protease attack (pepsin, trypsin, and proteinase k).The kinetics of bacterial growth and bacteriocin production by l.Plantarum c010 were analyzed during batch fermentation.Bacteriocin was produced throughout the logarithmic growth phase, and the leudeking-piret model characterized the synthesis of bacteriocins.The present study indicates that this novel bacteriocin produced by bacteria is a promising option for reducing spoilage microorganisms and can be widely used as a bio-preservative in meat and other foods.

Journal: World journal of microbiology & biotechnology (2022)
Publication types: Journal Article
Four Novel Mycoviruses from the HypovirulentBotrytis cinereaSZ-2-3y Isolate fromParis polyphylla: Molecular Characterisation and Mitoviral Sequence Transboundary Entry into Plants.

A hypovirulent sz-2-3y strain isolated from diseased paris polyphyllawas identified as botrytis cinerea.Interestingly, sz-2-3y was coinfected with a mitovirus, two botouliviruses, and a 3074 nt fusarivirus, designated botrytis cinerea fusarivirus 8 (bc fv8); it shares an 87.2% sequence identity with the previously identified botrytis cinerea fusarivirus 6 (bc fv6).The full-length 2945 nt genome sequence of the mitovirus, termed botrytis cinerea mitovirus 10 (bc mv10), shares a 54% sequence identity with fusarium boothii mitovirus 1 (fb mv1), and clusters with fungus mitoviruses, plant mitoviruses and plant mitochondria; hence bc mv10 is a new mitoviridaemember.The full-length 2759 nt and 2812 nt genome sequences of the other two botouliviruses, named botrytis cinerea botoulivirus 18 and 19 (bc bo v18 and 19), share a 40% amino acid sequence identity with rna-dependent rna polymerase protein (rd rp), and these are new members of the botoulivirusgenus of botourmiaviridae.Horizontal transmission analysis showed that bc bo v18, bc bo v19 and bc fv8 are not related to hypovirulence, suggesting that bc mv10 may induce hypovirulence.Intriguingly, a partial bc mv10 sequence was detected in cucumber plants inoculated with sz-2-3y mycelium or p xt1/bc mv10 agrobacterium.In conclusion, we identified a hypovirulent sz-2-3y fungal strain from p.Polyphylla, coinfected with four novel mycoviruses that could serve as potential biocontrol agents.Our findings provide evidence of cross-kingdom mycoviral sequence transmission.

Journal: Viruses (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Preparation and Characterization of Wood Scrimber Based on Eucalyptus Veneers Complexed with Ferrous Ions.

Wood-based products manufactured from fast-growing wood species such as eucalyptus have gained increasing attraction with the demand of using wood in architecture, furniture, and decoration.In this paper, a new type of wood scrimber based on eucalyptus veneers complexed with ferrous ions was prepared and its properties were characterized.The results showed that the presence of complexes did not affect the mechanical properties of eucalyptus wood scrimber, but made its surface more hydrophobic (contact angle increased by 38.48% and dimensional stability improved (thickness swelling rate decreased by 32.26%).Most importantly, the color of eucalyptus wood scrimber changed significantly, from the original brown to dark blue, and its anti-photoaging property also greatly improved.These advantages would make this type of wood scrimber based on the eucalyptus veneer complexes with ferrous ions more widely applicable in decorations and buildings.

Journal: Polymers (2022)
Publication types: Journal Article
Critical Role of Zinc Transporter (ZIP8) in Myeloid Innate Immune Cell Function and the Host Response against Bacterial Pneumonia.

Zinc (zn) is required for proper immune function and host defense.Zn homeostasis is tightly regulated by zn transporters that coordinate biological processes through zn mobilization.Zn deficiency is associated with increased susceptibility to bacterial infections, including streptococcus pneumoniae, the most commonly identified cause of community-acquired pneumonia.Myeloid cells, including macrophages and dendritic cells (dcs), are at the front line of host defense against invading bacterial pathogens in the lung and play a critical role early on in shaping the immune response.Expression of the zn transporter zip8 is rapidly induced following bacterial infection and regulates myeloid cell function in a zn-dependent manner.To what extent zip8 is instrumental in myeloid cell function requires further study.Using a novel, myeloid-specific,zip8knockout model, we identified vital roles of zip8 in macrophage and dc function upon pneumococcal infection.Administration of s.Pneumoniaeinto the lung resulted in increased inflammation, morbidity, and mortality in zip8knockout mice compared with wild-type counterparts.This was associated with increased numbers of myeloid cells, cytokine production, and cell death.In vitro analysis of macrophage and dc function revealed deficits in phagocytosis and increased cytokine production upon bacterial stimulation that was, in part, due to increased nf-κb signaling.Strikingly, alteration of myeloid cell function resulted in an imbalance of th17/th2 responses, which is potentially detrimental to host defense.These results (for the first time, to our knowledge) reveal a vital zip8- and zn-mediated axis that alters the lung myeloid cell landscape and the host response against pneumococcus.

Journal: Journal of immunology (Baltimore, Md. : 1950) (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
Plasma Matrix Metalloproeteinase-9 Is Associated with Seizure and Angioarchitecture Changes in Brain Arteriovenous Malformations.

Both angiogenesis and inflammation contribute to activation of matrix metalloproeteinase-9 (mmp-9), which dissolves the extracellular matrix, disrupts the blood-brain barrier, and plays an important role in the pathogenesis of brain arteriovenous malformations (bavms).The key common cytokine in both angiogenesis and inflammation is interleukin 6 (il-6).Previous studies have shown elevated systemic mmp-9 and decreased systemic vascular endothelial growth factor (vegf) in bavm patients.However, the clinical utility of plasma cytokines is unclear.The purpose of this study is to explore the relationship between plasma cytokines and the clinical presentations of bavms.Prospectively, we recruited naive bavm patients without hemorrhage as the experimental group and unruptured intracranial aneurysm (uia) patients as the control group.All patients received digital subtraction angiography, and plasma cytokines were collected from the lesional common carotid artery.Plasma cytokine levels were determined using a commercially available, monoclonal antibody-based enzyme-linked immunosorbent assay.Subgroup analysis based on hemorrhagic presentation and angiograchitecture was done for the bavm group.Pearson correlations were calculated for the covariates.Means and differences for continuous and categorical variables were compared using student's t and χ2tests respectively.Plasma mmp-9 levels were significantly higher in the bavm group (42,945 ± 29,991 pg/m l) than in the uia group (28,270 ± 17,119 pg/m l) (p < 0.001).Plasma mmp-9 levels in epileptic bavms (57,065 ± 35,732; n = 9) were higher than in non-epileptic bavms (35,032 ± 28,301; n = 19) (p = 0.049).Lower plasma mmp-9 levels were found in cases of bavm with angiogenesis and with peudophlebitis.Plasma mmp-9 is a good biomarker reflecting ongoing vascular remodeling in bavms.Angiogenesis and pseudophlebitis are two angioarchitectural signs that reflect mmp-9 activities and can potentially serve as imaging biomarkers for epileptic bavms.

Journal: Molecular neurobiology (2022)
Publication types: Journal Article
Protective Effect of Chitosan Oligosaccharide against Hydrogen Peroxide-Mediated Oxidative Damage and Cell Apoptosis via Activating Nrf2/ARE Signaling Pathway.

Chitosan oligosaccharide (cos), hydrolyzed and deacetylated from chitosan, has been reported to possess varieties of biological activities.Alzheimer's disease (ad) is a multifactorial progressive neurodegenerative disorder characterized by cognitive decline and memory loss, where oxidative stress was reported to be an overwhelming cause of the occurrence of ad.We have previously reported that cos could significantly decrease cell death, ros generation, and lipid peroxidation, though the potential mechanism was yet to be determined.This study was designed to investigate the neuroprotective effect of cos against hydrogen peroxide (h2o2)-induced oxidative stress and apoptosis in neuronal sh-sy5y cells.Our results indicated that cos could dose-dependently scavenge h2o2in the cell-free systems.Accordingly, cos markedly decreased h2o2-induced cell apoptosis and intracellular ros generation, while increased antioxidant capacity in sh-sy5y cells.Further, cos significantly reduced the expression of bax and upregulated bcl-2.The m rna and protein expression levels of nuclear nrf2, heme oxygenase 1 (ho-1), and nad(p)h: quinone oxidoreductase 1 (nqo1) were significantly increased upon cos treatment.Moreover, nrf2-si rna evidently reversed the promotive effect of cos on expression levels of ho-1 and nqo1, and are-driven transcriptional activity as determined by double-luciferase reporter gene assay.Besides, cos reversed h2o2-mediated increased phosphorylation of erk1/2 and p38 mapk.In conclusion, our findings indicate that cos could protect sh-sy5y cells from oxidative damage and apoptosis via regulating nrf2/are signaling pathway, which may provide new applications for the prevention and treatment of ad.

Journal: Neurotoxicity research (2021)
Publication types: Journal Article
Evaluating the tolerance and efficacy of laser-assisted delivery of tranexamic acid, niacinamide, and kojic acid for melasma: A single center, prospective, split-face trial.

Although many treatment options are available, the treatment of melasma remains challenging.To investigate the efficacy and safety of combined treatment for melasma with a quality (q)-switched 1064-nm neodymium: yttrium-aluminum-garnet (nd:yag) laser and a topical mixture of tranexamic acid, niacinamide, and kojic acid.Twenty-five patients with melasma were enrolled.One side of the face was treated with low-fluence q-switched 1064-nm nd:yag laser alone, while the other side was treated with a combination of laser treatment and a topical mixture of tranexamic acid, niacinamide, and kojic acid.Each treatment consisted of five sessions at 2-week intervals, and patients were followed up 4 weeks after the last treatment.Overall improvement was assessed using the hemi melasma area and severity index (masi) score.A specialized imaging system (markview®, psiplaus inc., suwon, korea) was used to record images of the patients' faces, and photographic assessment was performed by two independent evaluators at 2, 4, 6, 8, and 12 weeks using a five-point grading scale.Although both sides of the face showed clinical improvement, combination treatment demonstrated a greater improvement in the mean hemi masi score compared to laser treatment alone.Improvement in melasma at 12 weeks, according to the evaluation of patient images by two independent evaluators, was greater with combination treatment.This study demonstrated that the combination of treatment with a low-fluence q-switched 1064-nm nd:yag laser and a topical mixture of tranexamic acid, niacinamide, and kojic acid would be a good option for melasma treatment.

Journal: Dermatologic therapy (2022)
Publication types: Clinical Trial;Journal Article
Adiponectin, but Not TGF-β1, CTGF, IL-6 or TNF-α, May Be a Potential Anti-Inflammation and Anti-Fibrosis Factor in Keloid.

Introduction numerous studies have elucidated adiponectin as a negative impact on inflammation and tissue fibrosis.However, little is known about the relevance between adiponectin and inflammatory factors in keloid.Methods to clarify whether adiponectin plays a role in the inflammation and fibrosis of keloid, 50 patients with keloid and 50 healthy subjects were enrolled, we examined the serum and m rna expression levels of adiponectin, tgf-β1, ctgf, il-6 and tnf-α in normal skin tissues and keloid tissues by elisa and q pcr, respectively.Correlation analysis between serum concentration of adiponectin with vancouver scar scale (vss) scores and the age of patients with keloid was evaluated, and the adiponectin concentrations in patients with keloid between different genders were measured.We further examined the effects of adiponectin on tgf-β1 mediated expression of collagen i, fn and mmp-1 in normal fibroblasts (nfs) and keloid fibroblasts (kfs).Results we discovered that lower serum concentration and m rna expression of adiponectin, but higher tgf-β1, ctgf, il-6 and tnf-α levels were measured in patients with keloid compared with those in normal controls.Furthermore, there was a strong inverse correlation between the serum adiponectin levels and vss scores in patients with keloid, but not in ages, and there was no statistically difference between different genders.Moreover, adiponectin attenuated tgf-β1 mediated expression of collagen i and fn, and upregulated the expression level of mmp-1 in kfs, but not in nfs.In addition, the inhibitory effect of adiponectin on tgf-β1 was attenuated by ampk inhibitor compound c, but not pi3k/akt inhibitor ly294002.Discussion adiponectin may exert an anti-inflammation and anti-fibrosis role in the development of keloid.One of the underlying mechanisms may be the activation of the ampk signaling pathway.

Journal: Journal of inflammation research (2021)
Publication types: Journal Article
Patient-specific instrumentation makes sense in total knee arthroplasty.

Introduction patient-specific instrumentation (psi) for total knee arthroplasty (tka) surgery was initially developed to increase accuracy.The potential psi benefits have expanded in the last decade, and other advantages have been published.However, different authors are critical of psi and argue that the advantages are not such and do not compensate for the extra cost.This article aims to describe the recently published advantages and disadvantages of psi.Areas covered narrative description of the latest publications related to psi in accuracy, clinical and functional outcomes, operative time, efficiency, and other benefits.Expert opinion we have published high accuracy of the system, with a not clinically relevant loss of accuracy, significantly higher precision with psi than with conventional instruments, and a high percentage of cases in the optimal range and similar to that obtained with computer-assisted navigation, greater imprecision for tibial slope, a significant blood loss reduction, and time consumption, an acceptable and non-significant increase in the cost per procedure, and no difference in complications during hospital admission and at 90 days.We think that psi will not follow the scott parabola and that it will continue to be a valuable type of device in some instances of tka surgery.

Journal: Expert review of medical devices (2022)
Publication types: Journal Article
Elderly people's experiences in emergencies through access to other levels of health care.

To understand elderly people's experiences in emergencies through access to other levels of health care.Methods a phenomenological study in the light of heidegger, conducted with 19 elderly patients admitted to an emergency care unit of the city of salvador, between april and october 2019.Results ontic primacy: disposition of the experience of elderly people waiting for regulation; constitutional anguish and fear in the willingness to be an elderly person waiting for regulation in an emergency care unit; inappropriate elderly being suppressed while waiting for regulation; being an elderly person unveiled in the existential modality of being for death.Ontological primacy: heal how to be the presence of elderly people waiting for regulation.Final considerations elderly people being anguished and afraid, feelings that allow the questioning of their own being, who want a healing and seeks ways that allows an active and proper participation in care.

Journal: Revista brasileira de enfermagem (2021)
Publication types: Journal Article
Application of lymphoplasmapheresis in the treatment of severe myasthenia gravis.

Lymphoplasmapheresis (lpe) is a treatment that combines traditional plasma exchange and lymphocyte removal technique.It has been applied to treat a variety of autoimmune diseases, but its application value in the treatment of severe myasthenia gravis (mg) is not yet clear.Therefore, the aim of this study was to investigate the efficacy and safety of lpe in severe mg.Methods clinical data of 123 severe patients with mg (myasthenia gravis foundation of america clinical classification, class iv) who received lpe treatment were included in a retrospective analysis.Efficacy was evaluated by the change of quantitative myasthenia gravis score (qmgs) before and after treatment.Univariate and multivariate logistic regression analysis was used to explore clinical factors affecting efficacy.Results a total of 220 replacements were performed in 123 patients, with an average of 1.79 replacements per patient.The overall safety of lpe was good, and no serious adverse reactions occurred.After treatment, the mean qmgs of patients decreased significantly, from 23.40 ± 4.25 points before treatment to 17.93 ± 5.61 points after treatment, a decrease of 5.47 ± 4.16 points.75.6% of patients experienced remission of clinical symptoms.During a 2-month follow-up of 64 patients, a progressive improvement in qmgs was found.Each muscle group involved in mg responded well to lpe treatment.In addition, lpe significantly reduced the levels of ach r-ab and inflammatory cytokines in patients.Age ≥ 50 years and co-infection were unfavorable factors affecting the efficacy.Conclusions in this study cohort, lpe is safe for the treatment of severe mg and achieves good treatment outcome with fewer replacements.In patients with mg, the avoidance and timely control of infection are necessary.Our study provides a potential new treatment option for severe mg.

Journal: Frontiers in neurology (2022)
Publication types: Journal Article
Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer.

Alpha-fetoprotein (afp) entrance into cancer cells is mediated by afp receptors (afprs) and exerts malignant effects.Therefore, understanding the structure of afprs will facilitate the development of rational approaches for vaccine design, drug delivery, antagonizing immune suppression and diagnostic imaging to treat cancer effectively.Throughout the last three decades, the identification of universal receptors for afp has failed due to their complex carbohydrate polymer structures.Here, we focused on the two types of binding proteins or receptors that may serve as afprs, namely, the a) mucin receptors family, and b) the scavenger family.We presented an informative review with detailed descriptions of the signal transduction, cross-talk, and interplay of various transcription factors which highlight the downstream events following afp binding to mucin or scavenger receptors.We mainly explored the underlying mechanisms involved mucin or scavenger receptors that interact with afp, provide more evidence to support these receptors as tumor afprs, and establish a theoretical basis for targeting therapy of cancer.

Journal: Frontiers in oncology (2021)
Publication types: Journal Article;Review
Association between WeChat Use and Memory Performance among Older Adults in China: The Mediating Role of Depression.

Changes to memory performance in the course of aging may be influenced by behavioral factors.The use of social media among elderly people is increasing, but studying its effect on cognitive functions such as memory remains at an early stage of development.Meanwhile, the linking mechanisms underlying the association between social media use and memory performance, if any exist, have not been revealed.This study attempted to examine the association between the use of we chat, the most popular social media platform in china, and memory performance among older people, and to test the possible mediating role of depression underlying this association.Data were drawn from the five-wave survey of the china family panel study (cfps), and 4929 respondents aged 60 or older (mean age = 68.19, sd = 5.84, 48.2% females) were included.Based on the descriptive statistics, the chi-squared test, student'st-test, correlation analysis, and mediation analysis were conducted.The results indicated that the usage rate of we chat among the sample was 20.1%.After controlling for demographic variables, the use of we chat was related to higher levels of memory performance and lower levels of depression.Moreover, depression partially mediated the relationship between we chat use and memory performance.To maintain memory performance and promote cognitive health in the course of aging, using social media and alleviating depression merit special attention.

Journal: Behavioral sciences (Basel, Switzerland) (2022)
Publication types: Journal Article