syedzayyan/paper_mill_benchmark huggingface dataset:
Paper-Cutting Pattern Design Based on Image Restoration Technology

Paper-cutting is one of the valuable intangible cultural heritages of china, with distinctive features such as “round as the autumn moon, sharp as the wheat mane, square as the green brick, missing as the serrated teeth, and thread as the beard,” and is a widely spread folk art.The art of paper-cutting brings new inspiration to the design of structures, and by changing the topology of the raw material, the material/structure can undergo significant changes in physical properties, such as optical, thermal, acoustic, and mechanical aspects.The protection of intangible cultural heritage is a process of cultural self-awareness and a kind of cultural reflection and enlightenment.In the history of promoting socialist cultural development, the protection of “intangible heritage” paper-cutting is undoubtedly of great significance.The purpose of digital image repair is to restore the integrity of the broken image, and the process is to fill in the specified area of the digital image with information, requiring a natural transition between the filled area and the original area of the image and minimizing artificial traces, so that the image looks as if it has never been broken.In this paper, the paper-cutting pattern design method based on image restoration technology is investigated, starting from the preprocessing of paper-cutting images by acquiring the edges of the images and using the criminisi image restoration algorithm with image broken edge reconstruction to realize the image broken edge reconstruction design of paper-cutting graphics.Therefore, the paper-cut graphics generated by the method in this paper are concise and coherent as a whole, which reduces the difficulty of paper-cut design while satisfying individual design requirements.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Oxidative Stress and Its Related Factors in Latent Autoimmune Diabetes in Adults

S .Few research was reported to explore oxidative stress in individuals with latent autoimmune diabetes in adults (lada).Therefore, our goal is to study oxidative stress and related factors in lada patients.Methods .In this study, 250 chinese inpatients were diagnosed with lada ( n = 110) and type 2 diabetes mellitus ( n = 140) and 140 healthy volunteers were recruited.Moreover, individuals with lada were followed for 6 months to evaluate whether short‐term glycemic control during hospitalization can improve oxidative stress.Clinical and laboratory measurements of height, weight, blood pressure, glycosylated hemoglobin (hb a 1c ), blood lipids, 8‐isoprostaglandin f2 α (8‐iso‐pgf2 α ), and superoxide dismutase (sod) were performed.Stepwise multiple regression analyses were used to assess factors that related to oxidative stress in individuals with lada.Results .Compared with patients with type 2 diabetes, individuals with lada have better oxidative stress and worse oxidative stress than healthy volunteers.After multiple regression analyses, systolic blood pressure, hb a 1c , duration of diabetes, and diabetic retinopathy were associated with 8‐iso‐pgf2 α and hb a 1c .Diabetic retinopathy and diabetic ketosis were associated with sod in individuals with lada.Our results also revealed that, after 6 months of follow‐up, oxidative stress was improved to some extent in persons with lada.Conclusions .Our results show that compared with type 2 diabetes, lada means less oxidative stress, and compared with healthy volunteers, it means more oxidative stress.Systolic blood pressure, hb a 1c , duration of diabetes, diabetic retinopathy, and ketosis were associated with oxidative stress in individuals with lada.Furthermore, short‐term glycemic control can improve oxidative stress to some extent in individuals with lada.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Molecular Evolution of the Activating Transcription Factors Shapes the Adaptive Cellular Responses to Oxidative Stress

Reactive oxygen species (ros) play an essential part in physiology of individual cell.Ros can cause damage to various biomolecules, including dna.The systems that have developed to harness the impacts of ros are antique evolutionary adaptations that are intricately linked to almost every aspect of cellular function.This research reveals the idea that during evolution, rather than being largely conserved, the molecular pathways reacting to oxidative stress have intrinsic flexibility.The coding sequences of the atf2, atf3, atf4, and atf6 genes were aligned to examine selection pressure on the genes, which were shown to be very highly conserved among vertebrate species.A total of 33 branches were explicitly evaluated for their capacity to diversify selection.After accounting for multiple testing, significance was determined using the likelihood ratio test with a threshold of p ≤ 0.05 .Positive selection signs in these genes were detected across vertebrate lineages.In the selected test branches of our phylogeny, the synonymous rate variation revealed evidence (lrt, p value = 0.011 ≤ 0.05) of gene-wide episodic diversifying selection.As a result, there is evidence that diversifying selection occurred at least once on at least one test branch.These findings indicate that the activities of ros-responsive systems are also theoretically flexible and may be altered by environmental selection pressure.By determining where the genes encoding these processes are “targeted” during evolution, we may better understand the mechanism of adaptation to oxidative stress during evolution.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Organizational Silence among Hospital Nurses in China: A Cross-Sectional Study

To analyze the factors that contribute to organizational silence among chinese nurses.Methods .A descriptive, comparative, and cross‐sectional study was performed with the participation of 866 nurses from public hospitals in china.The data were collected using an online questionnaire that included sociodemographic information and a silence scale.Results.The overall level of organizational silence among nurses was moderate (51.35 ± 14.99).Nurses indicated that they remained silent about administrative (2.97 ± 1.10) and organizational topics (2.94 ± 1.11) yet were more vocal about matters related to responsibility (1.68 ± 0.86), honor (1.87 ± 0.95), and enthusiasm (2.07 ± 0.99).Moreover, data analysis demonstrated that department, educational status, professional title, years of employment, and employment status had effects on nurses’ organizational silence ( p &lt; .05).Conclusion.This study provides information that could facilitate an understanding of organizational silence for both nurses and nursing managers.The results helped to identify the urgent need to adopt effective strategies to address the problem of nurses’ organizational silence.Changes in management practices and organizational culture should be implemented to remove communication and other barriers that impede nurses’ contributions to their organizations.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Nutrigenomic Interventions to Address Metabolic Stress and Related Disorders in Transition Cows

For dairy cattle, the period involving a shift from late pregnancy to early lactation termed transition or periparturient is an excruciating phase.Health‐related disorders are likely to happen in this time frame.Timely postpartum and metabolic adjustments to this new physical state demands correct management strategies to fulfill the cow’s needs for a successful transition to this phase.Among the management strategies, one of the most researched methods for managing transition‐related stress is nutritional supplementation.Dietary components directly or indirectly affect the expression of various genes that are believed to be involved in various stress‐related responses during this phase.Nutrigenomics, an interdisciplinary approach that combines nutritional science with omics technologies, opens new avenues for studying the genome’s complicated interactions with food.This revolutionary technique emphasizes the importance of food‐gene interactions on various physiological and metabolic mechanisms.In animal sciences, nutrigenomics aims to promote the welfare of livestock animals and enhance their commercially important qualities through nutritional interventions.To this end, an increasing volume of research shows that nutritional supplementation can be effectively used to manage the metabolic stress dairy cows undergo during the transition period.These nutritional supplements, including polyunsaturated fatty acids, vitamins, dietary amino acids, and phytochemicals, have been shown to modulate energy homeostasis through different pathways, leading to addressing metabolic issues in transition cows.

Journal: BioMed Research International (2022)
Publication types: Review Article;
Observation of Clinical Efficacy of Anisodamine and Chlorpromazine in the Treatment of Intractable Hiccup after Stroke

This study is aimed at investigating the clinical efficacy of anisodamine combined with chlorpromazine on intractable hiccups after stroke.Methods .150 patients admitted to affiliated hospital of the hebei university of engineering from 2017 to 2021 were selected as the research objects, all of which received the computed tomography (ct) examination.During ct examination, intelligent algorithms were used to segment the images.An unsupervised multilayer image threshold segmentation algorithm was proposed by using kullback‐leibler (k‐l) divergence and the modified particle swarm optimization (mpso) algorithm.All patients were divided into three groups, with each group of 50 patients.Patients in the control group (group a) took the calcium tablets, vitamin c tablets, and vitamin b1 tablets orally.Patients in the control group (group b) received the acupoint injection of anisodamine, and those in the observation group (group c) received the acupoint injection of anisodamine combined with chlorpromazine.The therapeutic effect and patient satisfaction of the three groups were compared.Results .The two‐dimensional (2d) k‐l divergence was applied for the multilayer segmentation of images, which was helpful to obtain accurate images.The mpso algorithm was adopted to reduce the computational complexity.The total efficiency of group c was 98%, that of group b was 56%, and that of group a was 22%.The total efficiency and satisfaction rate of group c were signally better than those of group a and group b ( p &lt; 0.05).Conclusion .The combination of 2d k‐l divergence and mpso algorithm could improve the accuracy of multilayer image segmentation and ct imaging.Acupoint injection of anisodamine combined with chlorpromazine had better efficacy than the injection of anisodamine alone for the treatment of intractable hiccups after stroke, with high safety and clinical promotion value.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Noncoding RNAs Act as Tumor-Derived Molecular Components in Inducing Premetastatic Niche Formation

Cancer metastasis has been demonstrated as it is the culmination of a cascade of priming steps.Increasing evidence has shown that tumor-derived molecular components (tdmcs) are known as extra cellular vesicle and nonvesicle factors and serve as versatile intercellular communication vehicles which can mediate signaling in the tumor microenvironment while creating the premetastatic niche.Noncoding rnas (nc rnas) as one of the tdmcs have been proved in participating in the formation of the premetastatic niche.Understanding the premetastatic niche formation mechanisms through tdmcs, especially nc rnas may open a new avenue for cancer metastasis therapeutic strategies.In this review, recent findings regarding nc rnas function were summarized, and then the interaction with the premetastatic niche formation was studied, which highlight the potential of using nc rnas for cancer diagnosis and therapeutic effect.

Journal: BioMed Research International (2019)
Publication types: Review Article;
NEAT1 siRNA Packed with Chitosan Nanoparticles Regulates the Development of Colon Cancer Cells via lncRNA NEAT1/miR-377-3p Axis

This study was for verifying that transfecting colon cancer cells (cccs) with lnc rna neat1 packed with si rna chitosan nanoparticles (cnps) can suppress lnc rna neat1 and biological behaviors of the cells.Si rna targeting lnc rna neat1 expression vector was constructed and then transfected into cccs after being packed with cnps.Subsequently, the impact of the transfection on biological behaviors of the cells was evaluated.As a result, with high expression in cccs, neat1 was negatively bound up with mi r‐377‐3p in cases with colon cancer (cc), and dual luciferase reporter assay confirmed the potential binding region.Additionally, after downregulating neat1 in cccs, transfection of neat1 si rna packed with cnps brought a great inhibition on cell proliferation and a promotion on apoptosis, and inhibiting mi r‐377‐3p was able to offset the role of silencing neat1 in cccs.Therefore, in our opinion, neat1 si rna packed with cnps can hinder the growth and metastasis of cccs by knocking down neat1 in cc, and its mechanism may be achieved by targeting mi r‐377‐3p, which offers a novel direction for treating cc.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Nanobased Antibacterial Drug Discovery to Treat Skin Infections of Staphylococcus aureus Using Moringa oleifera-Assisted Zinc Oxide Nanoparticle and Molecular Simulation Study

In addition to the physical barrier, the epidermis acts as a natural barrier against microbial proliferation.It is prone to bacterial infections on the skin and in the nose, such as staphylococcus aureus, as well as a variety of other skin illnesses.Green nanomaterial production, which eliminates the use of harmful chemicals while simultaneously reducing time, is gaining popularity in the nanotechnology area.Using the leaf extract of the pharmacologically valuable plant moringa oleifera, we described a green synthesis of zn o nps (zinc oxide nanoparticles).Zn o nps had a particle size of 201.6 nm and a zeta potential of ‐56.80 m v, respectively.A novel aminoketone antibacterial medication was synthesized and tested for antibacterial activity using zn o nps as a phytocatalyst in this work.This method produces high yields while maintaining efficient and gentle reaction conditions.Moringa oleifera extract can reduce zn o to zn o nps in a straightforward manner.Ft‐ir, 1 h‐nmr, 13 c‐nmr, mass spectra, elemental analysis, and morphological analysis were used to synthesize and describe the antibacterial medicines (1a‐1g) and (2a‐2g).In addition, antibacterial activity was evaluated against bacteria such as enterococcus faecalis and staphylococcus aureus, and compound 1c (63 μ g/m l, e.Faecalis ) and compound 2e (0.12 μ g/m l, s.Aureus ) were found to be very active when compared to other medications.Mupirocin is used as a reference.In addition, studies of in silico molecular docking for the bacterial dsb a protein were conducted.The strong molecules 1c (‐4.3 kcal/mol) and 2e (‐5.1 kcal/mol) exhibit a high binding affinity through hydrogen bonding, according to docking tests.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Multiresolution-Based Singular Value Decomposition Approach for Breast Cancer Image Classification

Breast cancer is the most prevalent form of cancer that can strike at any age; the higher the age, the greater the risk.The presence of malignant tissue has become more frequent in women.Although medical therapy has improved breast cancer diagnostic and treatment methods, still the death rate remains high due to failure of diagnosing breast cancer in its early stages.A classification approach for mammography images based on nonsubsampled contourlet transform (nsct) is proposed in order to investigate it.The proposed method uses multiresolution nsct decomposition to the region of interest (roi) of mammography images and then uses z‐moments for extracting features from the nsct‐decomposed images.The matrix is formed by the components that are extracted from the region of interest and are then subjected to singular value decomposition (svd) in order to remove the essential features that can generalize globally.The method employs a support vector machine (svm) classification algorithm to categorize mammography pictures into normal, benign, and malignant and to identify and classify the breast lesions.The accuracy of the proposed model is 96.76 percent, and the training time is greatly decreased, as evident from the experiments performed.The paper also focuses on conducting the feature extraction experiments using morphological spectroscopy.The experiment combines 16 different algorithms with 4 classification methods for achieving exceptional accuracy and time efficiency outcomes as compared to other existing state‐of‐the‐art approaches.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Multifunctional Drug-Loaded Phase-Change Nanoparticles Inhibit the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Affecting the Activity of Activated Hepatic Stellate Cells

S .Preparation of a multifunctional drug‐loaded phase‐change nanoparticle (np), pirfenidone perfluoropentane liposome nps (ppl nps), and combined with low‐intensity focused ultrasound (lifu) to influence epithelial mesenchymal transition (emt) for hepatocellular carcinoma (hcc) by inhibiting the activity of activated hepatic stellate cells (a‐hscs ).Methods .Ppl nps were prepared by the thin film dispersion method.The appearance, particle size, zeta potential, encapsulation efficiency, drug loading rate, drug release in vitro, and stability of ppl nps were tested.The role of a‐hscs in hcc metastasis was studied by cck‐8, colony formation assay, apoptosis, cellular uptake assay, wound healing assay, and transwell assay.Western blot was used to detect the related protein expression levels.In vitro and vivo, the acoustic droplet vaporization (adv) of ppl nps was tested at different times and lifu intensities.Biosafety of the ppl nps was assessed by measuring nude mouse body weight and hematoxylin and eosin (h&amp;e) staining .Results.The results showed that the ppl nps had good biosafety, with an average particle size of 346.6 ± 62.21 nm and an average zeta potential of ‐15.23 m v.When the lifu power is 2.4 w/cm 2 , it can improve the permeability of cells, further promote the uptake of drugs by cells, and improve the toxicity of drugs.In vitro experiments showed that ppl nps could inhibit the proliferation of a‐hscs cells, thereby affecting the metastasis of hcc, and were related to the tgf β ‐smad2/3‐snail signaling pathway.Both in vivo and in vitro ppl nps enhanced ultrasound imaging by lifu‐triggered adv .Conclusion.The ppl nps designed and prepared in this study combined with lifu irradiation could significantly alter the emt of hcc by inhibiting lx2.Clinically, ppl nps will also be considered a promising contrast agent due to their ultrasound imaging capabilities.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Multidimensional CNN-Based Deep Segmentation Method for Tumor Identification

Weighted mr images of 421 patients with nasopharyngeal cancer were obtained at the head and neck level, and the tumors in the images were assessed by two expert doctors.346 patients’ multimodal pictures and labels served as training sets, whereas the remaining 75 patients’ multimodal images and labels served as independent test sets.Convolutional neural network (cnn) for modal multidimensional information fusion and multimodal multidimensional information fusion (mmmdf) was used.The three models’ performance is compared, and the findings reveal that the multimodal multidimensional fusion model performs best, while the two‐modal multidimensional information fusion model performs second.The single‐modal multidimensional information fusion model has the poorest performance.In mr images of nasopharyngeal cancer, a convolutional network can precisely and efficiently segment tumors.

Journal: BioMed Research International (2022)
Publication types: Research Article;
MSN@IL-4 Sustainingly Mediates Macrophagocyte M2 Polarization and Relieves Osteoblast Damage via NF-κB Pathway-Associated Apoptosis

The microenvironment of bone defects displayed that m2 polarization of macrophagocyte could promote the osteoblast growth and benefit the wound healing.Bone scaffold transplantation is considered to be one of the most promising methods for repairing bone defects.The present research was aimed at constructing a kind of novel bone scaffold nanomaterial of msn@il‐4 for treating bone defects responding to the wound microenvironment of bone defects and elucidating the mechanics of msn@il‐4 treating bone defect via controlling release of il‐4, inducing m2 polarization and active factor release of macrophagocyte, and eventually relieving osteoblast injury.Methods .Msn@il‐4 was firstly fabricated and its release of il‐4 was assessed in vitro.Following, the effects of msn@il‐4 nanocomplex on the release of active factors of macrophage were examined using elisa assay and promoting m2 polarization of the macrophage by immunofluorescence staining.And then, the effects of active factors from macrophage supernatant induced by msn@il‐4 on osteoblast growth were examined by cck‐8, flow cytometry, and western blot assay.Results .The release curve of il‐4 in vitro displayed that there was more than 80% release ratio for 30th day with a sustained manner in p h 5.5.Elisa assay data showed that msn@il‐4 nanocomplex could constantly promote the release of proproliferative cytokine il‐10, sdf‐1 α , and bmp‐2 in macrophagocyte compared to only il‐4 treatment, and immunofluorescent image showed that msn@il‐4 could promote m2 polarization of macrophagocytes via inducing cd206 expression and suppressing cd86 expression.Osteoblast injury data showed that the supernatant from macrophagocyte treated by msn@il‐4 could promote the osteoblast proliferation by mtt assay.Flow cytometry data showed that the supernatant from macrophagocyte treated by msn@il‐4 could suppress the osteoblast apoptosis from 22.1% to 14.6%, and apoptosis‐related protein expression data showed that the supernatant from macrophagocyte treated by msn@il‐4 could suppress the expression of bax, cleaved caspase 3, and cleaved caspase 8.Furthermore, the immunofluorescent image showed that the supernatant from macrophagocyte treated by msn@il‐4 could inhibit nucleus location of p65, and western blot data showed that the supernatant from macrophagocyte treated by msn@il‐4 could suppress the phosphorylation of ikk and induce the expression of i κ b.Conclusion .Msn@il‐4 could control the sustaining release of il‐4, and it exerts the protective effect on osteoblast injury via inducing m2 polarization and proproliferative cytokine of macrophagocyte and following inhibiting the apoptosis and nf‐ κ b pathway‐associated inflammation of osteoblast.

Journal: BioMed Research International (2022)
Publication types: Research Article;