syedzayyan/paper_mill_benchmark huggingface dataset:
Identifying patterns behind the changes in skin pores using 3-dimensional measurements and K-means clustering.

Skin pores are structural features of the skin, which tend to change as the skin ages.Since previous studies measured pores two-dimensionally, precise measurements using three-dimensional imaging were needed to comprehensively understand skin pores.This study aimed to determine the patterns behind the changes in skin pores during one's lifetime and to identify new characteristics of the pores in aged.Materials and methods skin surface profiles were measured three-dimensionally from the cheeks of 101 korean women from february to march 2020 to analyze the exact state of their pores.The researchers performed k-means clustering to classify the skin pores, and topographical features of pores were analyzed as well.Statistical analyses were performed to verify the differences in the skin pore characteristics among clusters and the correlation between clusters and ages.Results skin pores were classified into five groups based on size, density, and elongation.The skin conditions of the cluster groups were well correlated with aging, despite excluding age as a factor in pore classification.Adjacent skin pores tend to connect in the elderly.Conclusion skin pores become larger and longer over time.Skin pores connect together in the elderly, which might be related to wrinkle formation.This phenomenon strongly suggests skin pores as a characteristic of aging skin and as a potential target for anti-aging treatment.

Journal: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2022)
Publication types: Journal Article
Graph analysis of DTI-based connectome: decreased local efficiency of subcortical regions in PE patients with high sympathetic activity.

Introduction hyperactivity of the sympathetic nervous system was considered as one of the factors involved in the pathological mechanisms of premature ejaculation (pe).Sympathetic skin response of the penis (pssr) was used to evaluate the activity of sympathetic innervations in the penis, which was controlled by the central nervous system (brain).Shorter pssr was found in pe patients; however, little was known regarding the central neural mechanisms of pe patients with high sympathetic activity.Methods pssr of pe patients was evaluated, and diffusion tensor images of participants were collected.Graph theoretical analysis was employed to examine the differences of the topological properties of structural brain connectome between pe patients with high sympathetic activity and healthy controls (hcs).Moreover, the relationships between topological characteristics and clinical features in pe patients were also explored.Results decreased local efficacy was found in the left amygdala, right pallidum and thalamus in the white matter brain networks of pe when compared with hc (survived false discovery rate (fdr) correction).In addition, pe patients showed decreased global efficacy in the left amygdala and right rolandic operculum, supramarginal gyrus, heschl gyrus, inferior temporal gyrus, pallidum and thalamus; however, these results did not survive fdr correction.Finally, the local efficacy of right thalamus had a positive correlation with the premature ejaculation diagnostic tool (pedt) scores, while the local efficacy of left amygdala was negatively associated with the state score of the state-trait anxiety inventory (stai) and penile shaft sensory threshold.Conclusion the results highlighted the abnormal topological properties of structural brain connectome in pe with high sympathetic activity.We also suggested that the clinical features of pe were related to the abnormality of several brain regions involved in the central control of ejaculation and emotion.This study provided new insights into the central neural mechanisms of pe, which might offer biological markers for understanding the physiopathology of pe.

Journal: Andrology (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Preparation of AgNPs self-assembled solid-phase substrate via seed-mediated growth for rapid identification of different bacterial spores based on SERS.

In this study, we developed a novel and sensitive ag nps self-assembled solid-phase (ag nps-sasp) sers substrate platform using seed-mediated and liquid interface self-assembly methods and applied the platform for the detection of three bacterial spores.Multivariate statistical analysis (hca and lda) were employed for identification and categorization of the obtained data.The results illustrated that ag nps-sasp exhibited high reproducibility and raman enhancement effect (1.43 × 104).The raman shift bands of the three bacterial spores ranged from 400 to 1800 cm-1demonstrating the difference in reigon and intensity.And the intensities of their ca2+-dpa raman bands are significantly different.Hca results revealed that the spectra for the three bacterial spores were statistically different while lda completely differentiated the spectra for the three bacterial spores with 100 % sensitivity and specificity.Overall, the novel sers platform based on ag nps-sasp provides an effective tool for food safety risk control and detection.

Journal: Food research international (Ottawa, Ont.) (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A quantification method for Fe based particle contaminants in high purity materials for lithium-ion batteries.

The technological growth, the increasing safety, and production standards cascade down to the quality of the raw materials.The development of analytical methods for high quality powder analysis needs to grow parallel to this trend.It is established that particle metal contaminants could trigger violent failures of lithium-ion batteries and compromise the battery performance, and the safety of the end user.Increased miniaturization requires exponential increases in quality of raw materials putting laboratories in a continuous process of development to achieve ever higher standards.Trace elements in a powder material can be present in different states, and their effect on the application can therefore be different according to the status.Trace elements can be present in the material as a dissolved impurity or as a particle contamination.Here we present an experimental method which is easy to implement and use, and is sensitive to contaminants (i.e.External particles that are not part of the material of interest) over total trace elements.Contaminants typically are a few orders of magnitude lower in concentration than total trace elements.The method focuses on the quantification of fe, ni and cr in high purity carbon powders used in the lithium-ion battery industry.We present test sample size calculations prior to the method description to ensure high precision and assess possible bias.The method is based on the magnetic extraction of a large test sample, followed by acid digestion and quantification.The procedure and the method performance are described.The method ensures low levels of detection and quantification, high precision, and accuracy.

Journal: Talanta (2021)
Publication types: Journal Article
Early Labour App: Developing a practice-based mobile health application for digital early labour support.

Pregnant women in early labour have felt excluded from professional care, and their partners have been restricted from being involved in the birthing process.Expectant parents must be better prepared to deal with fear and stress during early labour.There is a need for evidence-based information and digital applications that can empower couples during childbirth.Objective to develop and identify requirements for a practice-based mobile health (m health) application for digital early labour support.Methods this research started with creating an expert group composed of a multidisciplinary team capable of informing the app development process on evidence-based practices.In consultation with the expert group, the app was built using an agile development approach (i.e., scrum) within a continuous software engineering setting (i.e., ci/cd, dev ops), also including user and security tests.Results during the development of the early labour app, two main types of challenges emerged: (1) user challenges, related to understanding the users' needs and experience with the app, and (2) team challenges, related to the software development team in particular, and the necessary skills for translating an early labour intervention into a digital solution.This study reaffirms the importance of midwife support via blended care and the opportunity of complementing it with an app.The early labour app was easy to use, the women needed little to no help, and the partner's preparation was facilitated.The combination of the app together with blended care opens up awareness, thoughts and feelings about the method and provides good preparation for the birth.Conclusion we propose the creation of the early labour app, a m health app for early labour support.The preliminary tests conducted for the early labour app show that the app is mature, allowing it to be used in the project's randomised control trial, which is already ongoing.

Journal: International journal of medical informatics (2023)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Long-Term Review of Penetrating Keratoplasty: A 20-Year Review in Asian Eyes.

To review the long-term outcomes of optical, therapeutic and tectonic forms of penetrating keratoplasty over a 20-year period in asian eyes.Design prospective cohort study involving the singapore corneal transplant study (scts).Methods all penetrating keratoplasties (pk) performed at the singapore national eye centre (snec) from january 1991 to december 2010 were analyzed using records from the computerized database of the scts.This database includes preoperative, intraoperative, and postoperative patient data and donor cornea data.Only primary grafts were included.Patient demographics, donor cornea source, indications for grafting, complications, graft survival rate, and causes of graft failure were analyzed.Results a total of 1,206 primary pks were performed.The mean age of the patients was 55 years (range: <1-101 years).The overall corneal graft survival rates at 1, 5, 10, 15, and 20 years were 91%, 66.8%, 55.4%, 52%, and 44%, respectively.For optical grafts, pseudophakic bullous keratopathy, postinfectious corneal scarring and thinning and keratoconus were the most common diagnoses.Graft survival for optical grafts was significantly better than therapeutic and tectonic grafts at all time points.Multivariate analysis suggested that a younger donor cornea age and higher donor endothelial cell count are associated with better long-term graft survival for optical grafts.Irreversible allograft rejection and late endothelial failure accounted for more than 60% of graft failures.Conclusions graft survival decreased over time from 91% at 1 year to 44% at 20 years' follow-up.Allograft rejection and late endothelial failure accounted for more than 60% of graft failures.

Journal: American journal of ophthalmology (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A Rare Case of Lung Hypoplasia in a 1-Year-Old Girl.

Pulmonary hypoplasia is a rare form of the congenital disorder that leads to lung underdevelopment.It is more common in children and infrequently noticed in adulthood.While congenital lung abnormalities are frequently discovered in the early years of life, these conditions are also often detected incidentally following routine radiographic imaging and investigations.We report the case of a 1-year-old girl who presented to the emergency department with a three-day history of cough, shortness of breath, fever, and respiratory distress.Investigations revealed right lung hypoplasia, left lung hyperinflation, and an invisible pulmonary artery and vein.A diagnosis of right lung hypoplasia as an incidental finding with associated anomalies was made.She was admitted to the pediatric ward and received supportive care and empirical antibiotics.She was then discharged in a good condition with supportive management for follow-up.This case report aims to describe a rare condition occurring in children with various clinical pictures and presentations to aid future early detection to achieve better diagnostic outcomes.

Journal: Cureus (2022)
Publication types: Case Reports;Journal Article
Molecular bases of morphologically diffused tumors across multiple cancer types.

Gastric cancer has two distinct subtypes: the diffuse (dgc) and the intestinal (igc) subtypes.Morphologically, the former each consists of numerous scattered tiny tumors while the latter each has one or a few solid biomasses.The former tends to be more aggressive and takes place in younger patients than the latter.While these have long been documented, little is known about the underlying causes.Our hypothesis is that the level of sialic acid (sa) accumulation on the cancer cell surfaces is a key reason for the observed differences.Our transcriptomic data-based analyses provide evidence that (i) dgcs tend to deploy more sas on cancer cell surfaces than igcs; (ii) this gives rise to considerably stronger cell-cell electrostatic repulsion in dgcs due to the negative charge that each sa carries; and (iii) such repulsion drives stronger cell protrusion and metastasis.Similar observations as well as our transcriptomic data-based predictions hold for multiple other cancer types, namely breast, lung, prostate plus liver and thyroid cancers, each known to have diffuse-like vs.Non-diffused subtypes as well as more aggressive behaviors like dgcs vs.Igcs.Hence, we speculate that the discovery presented here applies not only to gastric cancer but multiple and even potentially all cancer types having diffuse-like and non-diffused subtypes.

Journal: National science review (2022)
Publication types: Journal Article
Diagnosis and Surgical Treatment of Gastroenteropancreatic Neuroendocrine Neoplasms: A Literature Review.

This review aimed to highlight the characteristics and surgical treatments of tumours, and answer questions regarding the assessment of gastrointestinal neuroendocrine neoplasms (nens) and optimal therapy.Nens comprise tumours that can produce hormones and cause a secretory syndrome.The diagnostic method and accuracy differ depending on the site of occurrence; hence, the relevant scientific society has created nen treatment guidelines for each organ.Gastroenteric pancreatic (gep) nens have been unified and classified together according to the 2019 world health organization classification.Treatment is based on complete tumour resection, and when metastatic or primary lesions cannot be completely resected, lesions and symptoms are treated.Except for surgery for nens, chemotherapy, molecularly targeted drugs, transarterial chemoembolization, etc., have also been confirmed as treatments.Gep nen treatment methods will continue to advance and change because of surgery and other advances in treatment and diagnostic methods.

Journal: Cancer diagnosis & prognosis (2022)
Publication types: Journal Article;Review
Pulmonary Aspergilloma in a Young Immunocompetent Female: A Rare Clinical Dilemma.

Depending on the host's immunological and respiratory systems,aspergilluscan induce infectious and allergic diseases.Most of the spread occurs in immunocompromised people, whereas aggressive disorder in immunocompetent patients is unusual.We report the case of a 19-year-old female who had shortness of breath, right-sided chest discomfort, and intermittent hemoptysis for six months before being diagnosed with pulmonary aspergilloma.The initial chest x-ray revealed a massive right pneumothorax and a 7.2 cm rounded opacity in the right lower lung.A subsequent computed tomography (ct) chest with contrast revealed a 6.7 cm cavitating mass occupying the right lower lobe.An open right thoracotomy and right lower lobectomy showed a cavitary fungus ball with septate branching hyphae and subsequent methenamine silver staining consistent with aspergillusin conjunction with a positive aspergillusantigen.We strongly suggest that pulmonary aspergillosis should be suspected regardless of age or immunocompetence in patients with prolonged cough, hemoptysis, unilateral chest discomfort, and pneumothorax.

Journal: Cureus (2022)
Publication types: Case Reports;Journal Article
Interlaboratory Comparison of a Biomimetic Extraction Method Applied to Oil Sands Process-Affected Waters.

Biomimetic extraction using solid-phase microextraction is a passive sampling analytical method that can predict the aquatic toxicity of complex petroleum substances.The method provides a nonanimal alternative to traditional bioassays with the potential to reduce both vertebrate and invertebrate aquatic toxicity testing.The technique uses commercially available polydimethylsiloxane-coated fibers that, following nondepletive extraction of water samples, are injected into a gas chromatograph with flame ionization detection.As the predictive nature of the method is operationally defined, it is critical that its application be harmonized with regard to extraction, analysis, and standardization parameters.Results are presented from a round robin program comparing the results from 10 laboratories analyzing four different sample sets of dissolved organics in water.Samples included two incurred oil sands process-affected waters and a cracked gas oil water accommodated fraction.A fourth sample of cracked gas oil blended in an oil sands process-affected water was analyzed to demonstrate the method's ability to differentiate between neutral and ionizable dissolved hydrocarbons.Six of the 10 laboratories applied an automated version of the method using a robotic autosampler where the critical extraction steps are precisely controlled and which permits batch screening of water samples for aquatic toxicity potential.The remaining four laboratories performed the solid-phase microextraction manually.The automated method demonstrated good reproducibility with between-laboratory variability across the six laboratories and four samples yielding a mean relative standard deviation of 14%.The corresponding between-laboratory variability across the four laboratories applying the manual extraction was 53%, demonstrating the importance of precisely controlling the extraction procedure.Environ toxicol chem 2022;41:1613-1622.© 2022 the authors.Environmental toxicology and chemistry published by wiley periodicals llc on behalf of setac.

Journal: Environmental toxicology and chemistry (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Plasma Retinol Binding Protein 4 as a Biomarker for Detecting Progressive Stroke and Prediction of Early Prognosis in Patients with Acute Ischemic Stroke.

And purpose: progressive stroke (ps) lacks effective treatment measures and leads to serious disability or death.Retinol binding protein 4 (rbp4) could be closely associated with acute ischemic stroke (ais).We aimed to explore plasma rbp4 as a biomarker for detecting the progression in patients with ais.Methods participants of this retrospective study were 234 patients with ais within the 48 h onset of disease.The primary endpoint was to ascertain if there was ps through the national institute of health stroke scale (nihss); the early prognosis was confirmed through the modified rankin scale score (m rs) at discharge or 14 days after the onset of stroke, and the significance of demographic characteristics and clinical data was determined.Results in this study, 43 of 234 patients demonstrated ps.The level of plasma rbp4 in patients with progressive stroke was significantly lower (29 mg/l, 22.60-40.38 mg/l) than that without progression (38.70 mg/l, 27.28-46.40 mg/l, p = 0.003).In patients with lower plasma rbp4, the proportion of patients with progression (χ2 = 9.63, p = 0.008) and with m rs scores ≥2 (χ2 = 6.73, p = 0.035) was significantly higher.Multivariate logistic regression analysis showed that a lower rbp4 level on admission was an independent risk factor for progressive stroke during hospitalization with an or value of 2.70 (p = 0.03, 95% ci: 1.12-6.52).Conclusion a low plasma rbp4 level on admission could be an independent risk factor of ps during hospitalization.

Journal: Current neurovascular research (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Ceruloplasmin, Vitamin C, and Uric Acid Levels in Patients With Myocardial Infarction: A Comparative Cross-Sectional Study.

Introduction global mortality is significantly influenced by myocardial infarction.Scientists have examined the role of the copper-containing protein ceruloplasmin in heart attacks.It helps to regulate oxidative stress, iron metabolism, and inflammation.Vitamin c's antioxidative qualities lend credence to the idea that it could help prevent cardiovascular disease.Several studies have shown that elevated uric acid levels are related to a higher risk of myocardial infarction.With this background, we conducted this study to estimate levels of ceruloplasmin, vitamin c, and uric acid in patients with myocardial infarction.Materials and methods a tertiary care hospital in central india carried out this comparative cross-sectional study.The study was conducted between december 2022 and april 2023.Patients of any gender with newly diagnosed myocardial infarction who received admission to the intensive care unit and had st-segment elevation of at least 2 mm in two or more consecutive electrocardiogram leads were included in the patient group.The control group consisted of individuals who did not exhibit any changes associated with myocardial infarction.Based on sex, age, and body mass index, the 75 control and 75 patients were matched.Ceruloplasmin, vitamin c, and uric acid were analyzed and compared.Results the uric acid levels among the patient group were 10.34 ± 3.23 mg/d l, and among the controls, they were 3.45 ± 1.12 mg/d l (p<0.001).The ceruloplasmin levels among the patient group were 64.34 ± 4.21 mg/d l, and among the controls, they were 29.23 ± 3.82 mg/d l (p<0.001).The vitamin c levels among the patient group were 13.80 ± 0.94 μmol/l, and among the controls, they were 45.62 ± 4.34 μmol/l (p<0.001).Conclusion the patients with myocardial infarction demonstrated significantly elevated levels of ceruloplasmin and uric acid, while their vitamin c levels were lower in comparison.It is crucial to comprehend the underlying mechanisms through which these parameters influence the development of myocardial infarction.

Journal: Cureus (2024)
Publication types: Journal Article
Unravelling the effects of treated wastewater discharges on the water quality in a coastal lagoon system (Ria Formosa, South Portugal): Relevance of hydrodynamic conditions.

This study aimed to assess the influence of treated wastewater disposal on ria formosa coastal lagoon (south portugal), the largest national producer of bivalve mollusks.Water quality was evaluated at two areas under different wastewater loads and hydrodynamic conditions, using physico-chemical variables, bacterial indicators of contamination, chlorophyll-a concentration, phytoplankton abundance and composition.Samples were collected monthly, between october 2018 and september 2019.Minor influence of effluent discharge was detected at the eastern olhão area, exposed to stronger hydrodynamics and higher wastewater load than the northwestern faro area (ca.2-4-fold total nitrogen and phosphorus).The lower load weakly flushed area showed a poorer water quality, up to 500 m from the discharge point, more marked during the spring-summer period.The intensity, persistence, and spatial extent of the wastewater footprint, lower for the highest-loading area, reflected the role of local hydrodynamic conditions, modulating the influence of wastewater discharge on lagoonal water quality.

Journal: Marine pollution bulletin (2022)
Publication types: Journal Article