syedzayyan/paper_mill_benchmark huggingface dataset:
Anticipated and Perceived Stigma Among Patients With Psoriasis.

Perceived stigma among patients with psoriasis (pwp) is associated with poorer quality of life.Objective to determine the prevalence and predictors of stigmatizing attitudes that pwp expect and experience from others.Methods we conducted a survey using validated outcome measures to assess the extent to which pwp anticipate and perceive stigma from others.Demographic and clinical characteristics were obtained from electronic medical records.Results patients (n = 106) were 48.11% female, 70.75% white, and had a mean age ± sd of 47.90 ± 16.19 years old.Of all, 25.47% self-reported their psoriasis as severe.Mean physician global assessment score ± sd was 2.98 ± 1.81.Two-thirds (66.98%) of patients reported that, in response to seeing their psoriasis-affected skin, they anticipated others to stereotype them as "contagious." linear regression analyses demonstrated that patient-reported severe psoriasis, compared to mild psoriasis, was associated with greater anticipation of negative stereotypes, social avoidance, and perceived stigma from others (pvalues < .05).Physician-measured body surface area and global assessment scores were not significantly associated with any outcome.Conclusion prevalence of anticipated and perceived stigma among pwp is high.Our results suggest that objective measures of severity may not identify patients at risk of stigma-related distress.Additional methods, such as directly inquiring about stigmatizing experiences, may be needed.

Journal: Journal of psoriasis and psoriatic arthritis (2020)
Publication types: Journal Article
Neurocognitive Artificial Neural Network Models Are Superior to Linear Models at Accounting for Dimensional Psychopathology.

In recent years, there has been debate about the optimal conceptualisation of psychopathology.Structural models of psychopathology have been developed to counter issues, including comorbidity and poor diagnostic stability prevalent within the traditional nosological approach.Regardless of the conceptualisation of psychological dysfunction, deficits in neurocognitive abilities have been claimed to be an aetiological feature of psychopathology.Explorations of the association between neurocognition and psychopathology have typically taken a linear approach, overlooking the potential interactive dynamics of neurocognitive abilities.Previously, we proposed a multidimensional hypothesis, where within-person interactions between neurocognitive domains are fundamental to understanding the role of neurocognition within psychopathology.In this study, we used previously collected psychopathology data for 400 participants on psychopathological symptoms, substance use, and performance on eight neurocognitive tasks and compared the predictive accuracy of linear models to artificial neural network models.The artificial neural network models were significantly more accurate than the traditional linear models at predicting actual (a) lower-level and (b) high-level dimensional psychopathology.These results provide support for the multidimensional hypothesis: that the study of non-linear interactions and compensatory neurocognitive profiles are integral to understanding the functional associations between neurocognition and of psychopathology.

Journal: Brain sciences (2022)
Publication types: Journal Article
Ligand-mediated CsPbBrxI3-x/SiO2quantum dots for red, stable and low-threshold amplify spontaneous emission.

The red-emitting perovskite material has received widespread attention as a long-wavelength optical gain media.But the easy phase change in the air limits its practical application.Herein, red cs pb brx i3-x/si o2quantum dots (qds) are prepared by a ligand-mediated hot injection method in which 3-aminopropyl-triethoxysilane (aptes) is used instead of the usual oleylamine (oam) ligand.Through the hydrolysis of amino groups, a thin silicon layer is formed on the qd surface, improving the stability and without causing the aggregation of qds.We find that the ratio of i/br and the size of qds can be tuned by adjusting the aptes amount.Moreover, this ligand-mediated synthesis effectively passivates the surface defects, so the photoluminescence quantum yield is remarkably improved, and the carrier lifetime is prolonged.The amplified spontaneous emission is achieved under 532 nm nanosecond laser excitation.Compared with the original cs pb br i2-oam qd films, the threshold of cs pb brx i3-x/si o2qd films is reduced from 403.5 to 98.7μj cm-2, and the radiation stability is significantly enhanced.Therefore, this material shows great potential in the random laser field.

Journal: Nanotechnology (2022)
Publication types: Journal Article
Ankle Mortise Instability in Multiple Hereditary Exostoses.

Ankle valgus is commonly reported in patients with multiple hereditary exostoses (mhe).We report the characteristics of mortise widening in mhe, its progression over time, and the resultant ankle pain and function at skeletal maturity.Mortise medial space (m), talocrural angle (tc), and tibiotalar angle (tt) measurements were collected on preoperative and last follow-up radiographs.Operative data and complications were recorded.American orthopaedic foot and ankle society (aofas) and short form-36 scores at skeletal maturity were collected.A total of 16 patients (19 ankles) had mhe and mortise widening.Thirteen patients had surgery.Preoperatively, no patient complained of instability.However, 11 ankles (57.9%) were painful and 15 (78.9%) were clinically in valgus.Patients underwent surgery at a mean age of 11.8 ± 2.2 y.Operative interventions included medial distal tibia hemiepiphysiodesis for the majority of patients.There were no statistically significant differences between pre and postoperative m, tc, tt angles.Operative patients showed an improved mean m (5.17 ± 1.17 to 4.63 ± 1.06 mm) and tt (8.71 ± 5.40° to 4.54 ±7.58°), however, neither angle reached normal values.Tc representing fibular length-maintained measurements within normal limits (82.2 ± 5.3° to 84.8 ±5.8°).Questionnaires were obtained for 10 (52.6%) ankles.Mean age at questionnaires collection was 19.0 ± 3.6 y.Mean aofas score was 74.8 ± 17.6 out of 100.Patients scored 6.5 ± 4.1 out of 10 for alignment, 33.0 ± 6.7 out of 40 for pain, 35.3 ± 9.5 out of 50 for function.All short form-36 scores were above the national mean.Improvement of m and tt angles was modest.Tc angle was within normal limits but showed an overall fibular shortening and decreased lateral buttress and potential for talar shift, as reflected in aofas score.The underwhelming amount of mortise widening correction achieved may not provide for a stable ankle joint.

Journal: The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons (2022)
Publication types: Journal Article
Two siblings, distinct characteristics.

In this issue of structure, healy et al.Discovered the pdlim family of proteins as novel interactors of the sorting nexin snx17, determined the nmr structure of pdlim7 with the bound snx17 c terminus, and suggest that pdlim proteins could represent novel regulators of endosomal trafficking together with snx17.

Journal: Structure (London, England : 1993) (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Comment
Subjective sleep quality and fatigue assessment in Polish adult patients with primary immunodeficiencies: A pilot study.

Introduction primary immunodeficiencies (pids) are clinically heterogeneous disorders caused by abnormalities in the immune system.However, pids are genetically determined and may occur at any age from early childhood to elderly age.Due to chronic patterns, the risk of malignancy and organ damage in patients with pids may affect any aspect of life, including sleep patterns.To our knowledge, the prevalence of insomnia and subjective sleep quality have not been investigated in patients with pids.Therefore, this pilot study was conducted to investigate sleep quality, the prevalence of sleep disturbances, and fatigue in adult patients with pids in poland.Methods all participants were surveyed using the athens insomnia scale, pittsburgh sleep quality index, fatigue severity scale, and a questionnaire concerning general health and demographic data.We included 92 participants: 48 women (52.2%) and 44 men (47.8%).Results participants' mean age was 41.9 ± 13.9 years.The mean sleep duration was 7.0 ± 1.5 hours, and the mean sleep latency was 41.2 ± 53.1 minutes.Additionally, 44.6% of patients (n=41) had symptoms of insomnia and 44.6% (n=42) had poor sleep quality.Less than one-fourth (n=22; 23.9%) of the patients reported the use of sleeping pills; moreover, clinically significant fatigue was reported in 52.2% (n=48).Discussion our investigation provides insight into the problem of sleep disturbances in patients with pids.Data have demonstrated that sleeping disorders with concomitant fatigue are common in patients with pid.Further studies are needed to determine the determinants of poor sleep quality in this specific group of patients.

Journal: Frontiers in immunology (2022)
Publication types: Journal Article
Image-based parameter inference for epithelial mechanics.

Measuring mechanical parameters in tissues, such as the elastic modulus of cell-cell junctions, is essential to decipher the mechanical control of morphogenesis.However, their in vivo measurement is technically challenging.Here, we formulated an image-based statistical approach to estimate the mechanical parameters of epithelial cells.Candidate mechanical models are constructed based on force-cell shape correlations obtained from image data.Substitution of the model functions into force-balance equations at the cell vertex leads to an equation with respect to the parameters of the model, by which one can estimate the parameter values using a least-squares method.A test using synthetic data confirmed the accuracy of parameter estimation and model selection.By applying this method to drosophila epithelial tissues, we found that the magnitude and orientation of feedback between the junction tension and shrinkage, which are determined by the spring constant of the junction, were correlated with the elevation of tension and myosin-ii on shrinking junctions during cell rearrangement.Further, this method clarified how alterations in tissue polarity and stretching affect the anisotropy in tension parameters.Thus, our method provides a novel approach to uncovering the mechanisms governing epithelial morphogenesis.

Journal: PLoS computational biology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The S-layer homology domains of Paenibacillus alvei surface protein SpaA bind to cell wall polysaccharide through the terminal monosaccharide residue.

Self-assembling (glyco)protein surface layers (s-layers) are ubiquitous prokaryotic cell-surface structures involved in structural maintenance, nutrient diffusion, host adhesion, virulence, and other processes, which makes them appealing targets for therapeutics and biotechnological applications as biosensors or drug delivery systems.However, unlocking this potential requires expanding our understanding of s-layer properties, especially the details of surface-attachment.S-layers of gram-positive bacteria often are attached through the interaction of s-layer homology (slh) domain trimers with peptidoglycan-linked secondary cell wall polymers (scwps).Cocrystal structures of the slh domain trimer from the paenibacillus alvei s-layer protein spa a (spa aslh) with synthetic, terminal scwp disaccharide and trisaccharide analogs, together with isothermal titration calorimetry binding analyses, reveal that while spa aslhaccommodates longer biologically relevant scwp ligands within both its primary (g2) and secondary (g1) binding sites, the terminal pyruvylated man nac moiety serves as the nearly exclusive scwp anchoring point.Binding is accompanied by displacement of a flexible loop adjacent to the receptor site that enhances the complementarity between protein and ligand, including electrostatic complementarity with the terminal pyruvate moiety.Remarkably, binding of the pyruvylated monosaccharide scwp fragment alone is sufficient to cause rearrangement of the receptor-binding sites in a manner necessary to accommodate longer scwp fragments.The observation of multiple conformations in longer oligosaccharides bound to the protein, together with the demonstrated functionality of two of the three scwp receptor-binding sites, reveals how the spa aslh-scwp interaction has evolved to accommodate longer scwp ligands and alleviate the strain inherent to bacterial s-layer adhesion during growth and division.

Journal: The Journal of biological chemistry (2022)
Publication types: Journal Article
Real World Long-term Follow-up Experience with Yttrium-90 ibritumomab tiuxetan in Previously Untreated Patients with Low-Grade Follicular Lymphoma and Marginal Zone Lymphoma.

Introduction yttrium-90 ibritumomab tiuxetan [(90)y-it] is a cd20-targeted radio-immuno conjugate.Clinical trials of (90)y-it as a first-line stand-alone treatment in follicular lymphoma (fl) and/or marginal zone lymphoma (mzl) showed high efficacy.However, long-term survival outcomes and toxicities are not well-defined.Methods we report a retrospective single-institution, multi-center study of (90)y-it in previously untreated low grade (lg)-fl and mzl at mayo clinic cancer center between january 2000 and october 2019.We selected patients with lg-fl and mzl who received standard-dose (90)y-it as a single agent in the first line setting.Results the cohort (n = 51) consists of previously untreated lg-fl (n = 41) or mzl (n = 10).Median follow-up was 5.3 years (95% ci; 4.2, 6.2).Overall response rate (orr) was 100% with complete response rate (cr) of 94%.Continuous cr was observed in 59% patients who had more than 2 years of follow-up.Long-term cr (>7 years) was seen in 25% of patients.Median progression free survival (m pfs) for the whole cohort was not reached (nr) (95% ci; 4.9, nr).Bulky disease was associated with shorter median pfs of 3.5 years (ci 95%; 0.8, 4.9) compared to non-bulky disease nr (ci 95%; 5.8, nr), p = .02.The incidence of grade 3 or higher thrombocytopenia, neutropenia and anemia were 47%, 37%, and 4% respectively.No therapy-related myelodysplasia or acute myeloid leukemia were observed.Conclusion long real-life follow-up showed that single-agent (90)y-it is highly efficacious with durable long-term survival in previously untreated lg-fl and mzl without significant risk for secondary malignancies.

Journal: Clinical lymphoma, myeloma & leukemia (2022)
Publication types: Journal Article;Multicenter Study;Research Support, N.I.H., Extramural
Perfusion and Diffusion Variables Predict Early Neurological Deterioration in Minor Stroke and Large Vessel Occlusion.

And purpose patients with acute large vessel occlusion (lvo) presenting with mild stroke symptoms are at risk of early neurological deterioration (end).This study aimed to identify the optimal imaging variables for predicting end in this population.Methods we retrospectively analyzed 94 patients from the prospectively maintained institutional stroke registry admitted between january 2011 and may 2019, presenting within 24 hours after onset, with a baseline national institutes of health stroke scale score ≤5 and anterior circulation lvo.Patients who underwent endovascular therapy before end were excluded.Volumes of tmax delay (at >2, >4, >6, >8, and >10 seconds), mismatch (tmax >4 seconds - diffusion-weighted imaging [dwi] and tmax >6 seconds - dwi), and mild hypoperfusion lesions (tmax 2-6 and 4-6 seconds) were measured.The association of each variable with end was examined using receiver operating characteristic curves.The variables with best predictive performance were dichotomized at the cutoff point maximizing youden's index and subsequently analyzed using multivariable logistic regression.Results end occurred in 39.4% of the participants.The optimal variables were identified as tmax >6 seconds, tmax >6 seconds - dwi, and tmax 4-6 seconds with cut-off points of 53.73, 32.77, and 55.20 m l, respectively.These variables were independently associated with end (adjusted odds ratio [a or], 12.78 [95% confidence interval (ci), 3.36 to 48.65]; a or, 5.73 [95% ci, 2.04 to 16.08]; and a or, 9.13 [95% ci, 2.76 to 30.17], respectively).Conclusions tmax >6 seconds, tmax >6 seconds - dwi, and tmax 4-6 seconds could identify patients at high risk of end following minor stroke due to lvo.

Journal: Journal of stroke (2021)
Publication types: Journal Article
Long-term p21 and p53 dynamics regulate the frequency of mitosis events and cell cycle arrest following radiation damage.

Radiation exposure of healthy cells can halt cell cycle temporarily or permanently.In this work, we analyze the time evolution of p21 and p53 from two single cell datasets of retinal pigment epithelial cells exposed to several levels of radiation, and in particular, the effect of radiation on cell cycle arrest.Employing various quantification methods from signal processing, we show how p21 levels, and to a lesser extent p53 levels, dictate whether the cells are arrested in their cell cycle and how frequently these mitosis events are likely to occur.We observed that single cells exposed to the same dose of dna damage exhibit heterogeneity in cellular outcomes and that the frequency of cell division is a more accurate monitor of cell damage rather than just radiation level.Finally, we show how heterogeneity in dna damage signaling is manifested early in the response to radiation exposure level and has potential to predict long-term fate.

Journal: Cell death and differentiation (2023)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Research Support, N.I.H., Extramural;Research Support, U.S. Gov't, Non-P.H.S.
A generic self-assembly approach towards phototheranostics for NIR-II fluorescence imaging and phototherapy.

Controllable self-assembly of photonic molecules for precise biomedicine is highly desirable but challenging to prepare multifunctional nano-phototheranostics.Herein, we developed a generic self-assembly approach to design nano-phototheranostics that provides nir-ii fluorescence imaging and phototherapy.We first designed and synthesized two amphiphilic photonic molecules, peg2000-ir806 and bodipy.Then, we prepared the co-self-assembled phototheranostic agents, peg2000-ir806/bodipy nanoparticles (piby nps).The morphology of the piby nps is controllable by adjusting the ratio of peg2000-ir806 and bodipy during self-assembly.The nir-ii fluorescence properties and phototherapy capability of the piby nps were demonstrated in vitro and in vivo.By tuning the ratio of peg2000-ir806 and bodipy, the piby nps showed various morphologies (e.g.Spherical nanoparticles, nanovesicles and rod-like nanoparticles).The peg2000-ir806 plays two roles in the co-self-assemblies, one is second near-infrared (nir-ii, 1000-1700 nm) agent, the other is the surfactant for bodipy encapsulation.The phototherapeutic piby nps all show bright nir-ii fluorescence and effective phototherapeutic (photothermal and photodynamic) properties, which are attributed to ir806 and bodipy, respectively.The driving force of the self-assembly can be attributed to the electrostatic interaction between nir806 and bodipy and their hydrophobicity.The rod-like piby nps (r piby nps) demonstrated a low half inhibitory concentration (ic50) of 3.96 μg/m l on u87mg cells.The nir-ii imaging showed the accumulation of r piby nps in the tumor region.After systemic injection of r piby nps at low dose (0.5 mg/kg), the tumor growth was greatly inhibited upon laser irradiation without noticeable side effects.This study provides a generic self-assembly approach to fabricate nir-ii imaging and phototherapeutic platform for cancer phototheranostics.Statement of significance: nanophototheranostics providing nir-ii fluorescence imaging and phototherapy are expected to play a critical role in modern precision medicine.Controllable self-assembly of optical molecules for the fabrication of efficient nanophototheranostics is highly desirable but challenging.This work reports for the first time the co-assembly of a nir-ii imaging contrast agent and a phototherapeutic agent to yield nanophototheranostics with various morphologies.The design of molecular co-assembly with complementary optical functions can be a generic method for future the development of phototheranostics.

Journal: Acta biomaterialia (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Molecular, morphometric and digital automated identification of threeDiaphorinaspecies (Hemiptera: Liviidae).

Diaphorina is a species-rich genus, native to the tropics and subtropics of the old world, particularly of more arid regions.One of the species, diaphorina citri, is the economically most important pest of citrus.Diaphorina species are morphologically similar which makes their identification difficult.In this study, the accuracy of dna barcoding, using mitochondrial cytochrome c oxidase subunit 1 (coi), geometric morphometrics of the forewing and digital image processing methods were tested for identification of the three diaphorina species: d.Chobauti, d.Citri and d.Zygophylli.Moreover, the published coi sequences of d.Citri, d.Communis and d.Lycii obtained from genbank were used for cluster analyses.Dna barcodes for d.Chobauti and d.Zygophylli are deposited in genbank for the first time.The results of the molecular and geometric morphometric analyses are congruent and place d.Chobauti as the sister taxon of the other diaphorina species.The geometric morphometric analysis shows that in d.Zygophylli the fore margin is slightly curved proximally and sharply bent distally, while in d.Chobauti and d.Citri it is straight proximally and weakly bent distally.The results of digital image processing show that the distribution of the dark pattern differs consistently in the three studied species.

Journal: Bulletin of entomological research (2021)
Publication types: Journal Article
Composite Outcomes in Clinical Prediction Modeling: Are We Trying to Predict Apples and Oranges?

Composite outcomes are widely used in clinical research.Existing literature has considered the pros and cons of composite outcomes in clinical trials, but their extensive use in clinical prediction has received much less attention.Clinical prediction assists decision-making by directing patients with higher risks of adverse outcomes toward interventions that provide the greatest benefits to those at the greatest risk.In this article, we summarize our existing understanding of the advantages and disadvantages of composite outcomes, consider how these relate to clinical prediction, and highlight the problem of key predictors having markedly different associations with individual components of the composite outcome.We suggest that a "composite outcome fallacy" may occur when a clinical prediction model is based on strong associations between key predictors and one component of a composite outcome (such as mortality) and used to direct patients toward intervention when these predictors actually have an inverse association with a more relevant component of the composite outcome (such as the use of a lifesaving intervention).We propose that clinical prediction scores using composite outcomes should report their accuracy for key components of the composite outcome and examine for inconsistencies among predictor variables.

Journal: Annals of emergency medicine (2022)
Publication types: Journal Article