syedzayyan/paper_mill_benchmark huggingface dataset:
Value estimation and latent-state update-related neural activity during fear conditioning predict posttraumatic stress disorder symptom severity.

Learning theories of posttraumatic stress disorder (ptsd) purport that fear-learning processes, such as those that support fear acquisition and extinction, are impaired.Computational models designed to capture specific processes involved in fear learning have primarily assessed model-free, or trial-and-error, reinforcement learning (rl).Although previous studies indicated that aspects of model-free rl are disrupted among individuals with ptsd, research has yet to identify whether model-based rl, which is inferential and contextually driven, is impaired.Given empirical evidence of aberrant contextual modulation of fear in ptsd, the present study sought to identify whether model-based rl processes are altered during fear conditioning among women with interpersonal violence (ipv)-related ptsd (n = 85) using computational modeling.Model-free, hybrid, and model-based rl models were applied to skin conductance responses (scr) collected during fear acquisition and extinction, and the model-based rl model was found to provide the best fit to the scr data.Parameters from the model-based rl model were carried forward to neuroimaging analyses (voxel-wise and independent component analysis).Results revealed that reduced activity within visual processing regions during model-based updating uniquely predicted higher ptsd symptoms.Additionally, after controlling for model-based updating, greater value estimation encoding within the left frontoparietal network during fear acquisition and reduced value estimation encoding within the dorsomedial prefrontal cortex during fear extinction predicted greater ptsd symptoms.Results provide evidence of disrupted rl processes in women with assault-related ptsd, which may contribute to impaired fear and safety learning, and, furthermore, may relate to treatment response (e.g., poorer response to exposure therapy).

Journal: Cognitive, affective & behavioral neuroscience (2022)
Publication types: Journal Article
Detecting Potential Underreporting of Suicide Ideation Among U.S. Military Personnel.

Using a military sample comprised largely of national guard personnel, zero-inflation negative binomial regression was applied to estimate the effects of indirect, nonface valid indicators of suicide ideation [thwarted belongingness (tb), perceived burdensomeness (pb), and hopelessness], in predicting suicide ideation.Data from a sample of 497 military personnel (82.1% male; mage= 27.24; range = 18-59) were analyzed.Tb and the interaction of tb with hopelessness were significant predictors in the logistic regression, and in the negative binomial regression, the main effects of tb and hopelessness, and the interactions of tb with hopelessness and pb with hopelessness were significant.The findings further indicated that approximately 10% of those not reporting ideation would be predicted to be ideators.Clinically, these results indicate that, in samples reluctant to report ideation, the assessment of suicide risk may improve through the use of relevant measures that do not explicitly reference suicide thoughts.

Journal: Suicide & life-threatening behavior (2019)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.
Additive and nonadditive effects of salmon calcitonin and omega-3 fatty acids on antioxidant, hematological and bone and cartilage markers in experimental diabetic-osteoarthritic rats.

Reports on the coexistence of diabetes mellitus and osteoarthritis in human subjects dated back to the 1960s.However, there is no account in literature on the co-manifestation of these disease conditions in experimental animals.In our previous study, we reported for the first time, the effects of pharmacological agents on glucoregulatory indices, lipid profile, and inflammatory markers in experimental diabetic-knee osteoarthritic rat.However, in the present study, the effects of salmon calcitonin (sct), and/or omega-3 fatty acids (n-3) were further investigated on other biomarkers.Forty-nine rats of seven animals per group were used for this study.Diabetes was induced by the administration of streptozotocin (65 mg/kg) and nicotinamide (110 mg/kg).Thereafter, knee osteoarthritis was induced by the intra-articular injection of 4 mg of sodium monoiodoacetate in 40 μl of saline.Nine days after the inductions, treatments started, and they lasted for 4 weeks.N-3 was administered at 200 mg/kg/day, while sct was administered at 2.5 and 5.0 iu/kg/day.The results of the study indicated that the induced diabetes-knee osteoarthritis caused significant alterations in all the observed biomarkers.Sct showed a dose-specific effect and an additive action with n-3 in reducing malondialdehyde and lactate dehydrogenase, and in elevating total bilirubin and total antioxidant capacity.However, it largely demonstrated a nondose-specific effect and nonadditive action with n-3 on superoxide dismutase, catalase, glutathione peroxidase, total alkaline phosphatase, c-telopeptide of type-i collagen, collagen type-2 alpha 1, and hematological indices.In conclusion, the combined administration of sct and n-3 proffer better therapeutic effects than the single therapy; therefore, they could be used in the management of diabetic-osteoarthritic condition.

Journal: The Chinese journal of physiology (2019)
Publication types: Journal Article
The effect of visfatin genotype on insulin pump therapy on quality of life in patients with type I diabetes.

Diabetes is associated with an increase in other chronic diseases and an increase in mortality.The individual differences influence the treatment of this disease in pharmacokinetics and clinical responses.One of the important factors related to individual differences includes genetic factors in transmission, metabolism, and drug function.On the other hand, this disease has a significant impact on the patients' quality of life and their family.Therefore, this study aimed to investigate the role of single nucleotide polymorphism (rs2110385) of the visfatin gene on insulin required to maintain glucose homeostasis and to evaluate the effect of insulin pump therapy on the quality of life in type 1 diabetic patients.In this regard, this study was performed on 47 patients with type 1 diabetes.The short form of the diabetes quality of life questionnaire (dqol) was used to record information.Laboratory tests also included fbs, hb a1c, g2h, serum levels of visfatin, insulin, and adiponectin.Insulin resistance (homa) and insulin sensitivity (quicki) indices were calculated.The polymorphism of the studied genotype was performed by the pcr-rflp method.The results showed that the scores of both dimensions of quality of life, including patient care behaviors and satisfaction with the disease control after the intervention increased significantly (p <0.001).There was a significant and direct relationship between the patient's age and the duration of the disease with the score of increasing patients' quality of life.No significant differences were found between hb a1c, g2h, fbs levels, fasting insulin concentration, homa, and quicki indices.The insulin dose used to maintain glucose homeostasis at the same levels was significantly lower in the gg genotype than in other genotypes.In general, the present study results showed that insulin pump therapy and its dimensions could improve the life quality of patients with type 1 diabetes.Also, genetic evaluation of individuals helps to provide the correct and accurate dose of insulin with the help of the insulin pump for these patients to increase their quality of life as much as possible.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) (2022)
Publication types: Journal Article
Incidence and Predictors of Hypertension Among HIV Patients Receiving ART at Public Health Facilities, Northwest Ethiopia: A One-Year Multicenter Prospective Follow-Up Study.

The introduction of highly active retroviral therapy has dramatically reduced mortality and improved survival among hiv patients.However, there is a possible risk of comorbid complications such as hypertension.Little evidence is available regarding the incidence of hypertension among hiv patients receiving anti-retroviral therapy in ethiopia.Purpose to assess the incidence and predictors of hypertension among hiv positive patients receiving art at public health facilities, northwest ethiopia.Patients and methods a one-year prospective follow-up study was conducted among a cohort of 302 new adult individuals initiating on a standard anti-retroviral therapy regimen with a median (iqr) age of 35 years (iqr=30-41).A pretested data extraction checklist was used to extract baseline patient records.The collected data were entered into epi-data version 3.1 and exported to stata version 14 for analysis.The incidence rate was calculated, and a kaplan-meier survival curve was used to estimate the survival probabilities of developing hypertension.Cox proportional hazards model was fitted to identify the predictors of hypertension.Results about 40 (13.25) new hypertensive cases were observed during the follow-up period, and the remaining 262 (86.75%) were censored.The overall incidence rate of hypertension was 16.35 per 1000 person-month with 2447 patient-month observations.Male sex (ahr = 2.45, 95% ci: 1.02, 6.14), old age (ahr = 2.83, 95% ci: 1.08, 7.45), high bmi (ahr = 6.54, 95% ci: 2.03, 21.13), diabetic comorbidity (ahr = 2.36, 95% ci: 1.07, 5.22), and patients who were on zidovudine (azt)-based art regimen (ahr =3.47, 95% ci: 1.10, 10.94) were significant predictors for the development of hypertension.Conclusion the findings of this study revealed that incident hypertension is a common problem among hiv patients receiving art.Routine monitoring of blood pressure and screening and treating high blood pressure should be an integral part of follow-up for hiv patients in art clinics.

Journal: HIV/AIDS (Auckland, N.Z.) (2021)
Publication types: Journal Article
Performance and modelling of retention in microemulsion liquid chromatography.

The capability of liquid chromatography with microemulsions (mes) as mobile phases was studied for the analysis of four parabens (butylparaben, ethylparaben, methylparaben, and propylparaben) and seven β-adrenoceptor antagonists (acebutolol, atenolol, carteolol, metoprolol, oxprenolol, propranolol, and timolol).Mes were formed by mixing aqueous solutions of the anionic surfactant sodium dodecyl sulphate, the alcohol 1-butanol that played the role of co-surfactant, and octane as oil.In order to guarantee the formation of stable mes, a preliminary study was carried out to determine the appropriate ranges of concentrations of the three components.For this purpose, mixtures of variable composition were prepared, and the possible separation of two phases (formation of an emulsion) was visually detected.The advantage offered by the addition of octane to micellar mobile phases, inside the concentration range that allows the formation of stable mes, was evaluated by comparing the retention behaviour, peak profile and resolution of mixtures of the probe compounds, in the presence and absence of octane.The final aim of this work was the proposal of a mathematical equation to model the retention behaviour in microemulsion liquid chromatography.The derived global model that considered the three factors (surfactant, alcohol and oil) allowed the prediction of retention times at diverse mobile phase compositions with satisfactory accuracy (in the 1.1‒2.5% range).The behaviour was compared with that found with mobile phases without octane.The model also yielded information about the retention mechanism and revealed that octane, when inserted inside the micelle, modifies the interaction between solutes and micelles.

Journal: Journal of chromatography. A (2020)
Publication types: Journal Article
First Metatarsal Bone Metastasis From Clear Cell Renal Cell Carcinoma on SPECT/CT.

We report metatarsal metastasis in spect/ct in a 65-year-old man, 5 years after radical right nephrectomy.Tumor from first metatarsal was histopathologically proven from clear cell renal cell carcinoma.Metatarsal metastasis is very rare.Less than 0.01% of patients have metastases in the foot bone.Tumor histotype is mainly lung cancer.Metastases from renal carcinoma are often lytic with a poor osteoblastic response, there may be limited uptake of the 99m tc-mdp tracer, and all uncertain regions should be diagnosed with spect/ct, if it is possible.

Journal: Clinical nuclear medicine (2022)
Publication types: Case Reports;Journal Article
Anti-Tumor Effect ofMarshallagia marshalliSomatic Antigen on Inhibition Cell Growth of K562.

Today, the inhibitory effect of helminths on tumor cell growth has been proven.We investigated the anti-tumor activity of marshallagia marshallisomatic against k562 cells.Methods different concentrations of m.Marshallisomatic antigen were incorporated in the culture medium of k652 cells, and the proliferation and apoptosis were measured after 24, 48, and 72 h, using mtt and annexin v/pi staining assay.Results treatment of cells with 1-2 mg/ml antigen for 24-72 h could suppress cell proliferation and increase apoptosis.While treating cells with 0.1 mg/ml antigen for 72 h could inhibit cell growth.There was no meaningful effect on treated cells in comparison with the control group (p< 0.05) after incubating cells for 24- 48 h with 0.1 mg/ml antigen.Conclusion m.Marshallisomatic antigen had an anti-cancer property, and its role in cancer treatment could be considered as an effective therapeutic method.

Journal: Iranian journal of parasitology (2022)
Publication types: Journal Article
Lido-OH, a Hydroxyl Derivative of Lidocaine, Produced a Similar Local Anesthesia Profile as Lidocaine With Reduced Systemic Toxicities.

Lidocaine is one of the most commonly used local anesthetics for the treatment of pain and arrhythmia.However, it could cause systemic toxicities when plasma concentration is raised.To reduce lidocaine's toxicity, we designed a hydroxyl derivative of lidocaine (lido-oh), and its local anesthesia effects and systemic toxicityin vivowere quantitively investigated.method:the effectiveness for lido-oh was studied using mouse tail nerve block, rat dorsal subcutaneous infiltration, and rat sciatic nerve block models.The systemic toxicities for lido-oh were evaluated with altered state of consciousness (asc), arrhythmia, and death in mice.Lidocaine and saline were used as positive and negative control, respectively.The dose-effect relationships were analyzed.results:the half effective-concentration for lido-oh were 2.1 mg/ml with 95% confident interval (ci95) 1.6-3.1 (lidocaine: 3.1 mg/ml with ci95 2.6-4.3) in tail nerve block, 8.2 mg/ml with ci95 8.0-9.4 (lidocaine: 6.9 mg/ml, ci95 6.8-7.1) in sciatic nerve block, and 5.9 mg/ml with ci95 5.8-6.0 (lidocaine: 3.1 mg/ml, ci95 2.4-4.0) in dorsal subcutaneous anesthesia, respectively.The magnitude and duration of lido-oh were similar with lidocaine.The half effective doses (ed50) of lido-oh for acs was 45.4 mg/kg with ci95 41.6-48.3 (lidocaine: 3.1 mg/kg, ci95 1.9-2.9), for arrhythmia was 16.0 mg/kg with ci95 15.4-16.8 (lidocaine: 3.0 mg/kg, ci95 2.7-3.3), and for death was 99.4 mg/kg with ci95 75.7-124.1 (lidocaine: 23.1 mg/kg, ci95 22.8-23.4).The therapeutic index for lido-oh and lidocaine were 35.5 and 5.6, respectively.conclusion:compared with lidocaine, lido-oh produced local anesthesia at similar potency and efficacy, but with significantly reduced systemic toxicities.

Journal: Frontiers in pharmacology (2021)
Publication types: Journal Article
Phenotype and genotype in a Taiwanese girl with Sotos Syndrome.

Rare copy number variations have been linked to an important source of mutation in many psychopathological traits and neurodevelopmental disorders.In this study, we describe a taiwanese girl with mental retardation and mild macrocephaly who underwent a childhood psychological evaluation for several years first.When she was 5 years old, she came to our hospital for further diagnosis.We conducted molecular cytogenetic tests and confirmed she actually has sotos syndrome.We compared our case with two others with very similar deletion regions, but their phenotypes were heterogeneous.Sotos syndrome is very rare in taiwan, and it is suggested that genetic analysis should be considered early if symptoms of this case are observed.

Journal: BioMedicine (2022)
Publication types: Journal Article
Investigation of Long-Term Roving Artisanal and Small-Scale Gold Mining Activities Using Time-Series Sentinel-1 and Global Surface Water Datasets.

Artisanal and small-scale gold mining (asgm) is a significant source of gold production globally despite the sector being informal and illegal.The rapid increase in the number of roving mining camps has negatively impacted the surrounding environment; however, the formation and transformation of roving mining camps have not been well studied.This study investigated the long-term trends and significant hotspots of roving camp-type asgm (r-c-asgm) in katingain regency, central kalimantan province, indonesia, from 1988 to 2020 using remotely sensed data, including sentinel-1 time-series, global surface water (gsw), and world landcover datasets.Results show that several active r-c-asgm sites existed in the galangan and kalanaman areas in 2017/2018.According to the gsw dataset, the galangan area was estimated to be formed earlier, whereas the kalanaman areas were recently formed and were associated with the kalanaman river expansion.Notably, the center of galangan was still a significant r-c-asgm hotspot.The findings of this study broaden our understanding of r-c-asgm transformation and identify significant r-c-asgm hotspots over a long period.This study contributes to the development of timely and appropriate interventions for strengthening environmental governance.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Genomic Inverse PCR for Screening of Preleukemic Cells in Newborns (GIPFEL Technology).

Recurrent chromosomal translocations define genetic subtypes of childhood leukemia and present the first hit that generates an expanded clone of preleukemic cells in the bone marrow.Most commonly, reverse transcriptase pcr is used to detect these translocations on rna level.This technique has severe drawbacks, including sensitivity to contamination and instability of rna.Here, we describe the genomic inverse pcr for exploration of ligated breakpoints (gipfel) that overcomes these pitfalls.

Journal: Methods in molecular biology (Clifton, N.J.) (2021)
Publication types: Journal Article
Too much to know? The cognitive demands of daily knowledge seeking and the buffering role of coworker contact quality.

To get their work done and achieve their daily work-related goals, employees seek knowledge from their coworkers.While the benefits of knowledge seeking have been established in the literature, we have yet to understand the potential downsides of daily knowledge seeking.We adopt a cognitive perspective to carve out the negative effect of daily knowledge seeking, while controlling for its established positive effect via perceived learning.Based on cognitive load theory, we argue that daily knowledge seeking produces intrinsic cognitive load that can hinder daily goal attainment through the experience of knowledge overload and subsequent resource depletion.However, the relational context in which knowledge seekers interact with knowledge sources represents an important contextual boundary condition.Coworker contact quality can mitigate the effect of knowledge seeking on knowledge overload because high coworker contact quality reduces extraneous (i.e., ineffective) and increases germane (i.e., productive) cognitive load that knowledge seekers experience when navigating the social interaction with knowledge sources.Under this condition, cognitive capacity is freed up and knowledge overload is less likely to occur.Based on an experience sampling study in which we collected data across 10 working days from 189 german employees, we found support for our hypotheses.An employee's knowledge seeking had a negative indirect effect on goal attainment via knowledge overload and subsequent resource depletion, however, the downsides of daily knowledge seeking became less pronounced when coworker contact quality increased.We discuss the implications of our findings for research on knowledge seeking and resource exchange behaviors.(psyc info database record (c) 2022 apa, all rights reserved).

Journal: The Journal of applied psychology (2022)
Publication types: Journal Article
Biopsychosocial approach to understanding determinants of depression among men who have sex with men living with HIV: A systematic review.

Introduction men who have sex with men (msm) living with hiv are more likely to be depressed than msm without hiv.The aids epidemic will not end if the needs of people living with hiv and the determinants of health are not being addressed.Compared to hiv individuals without depression, depressed hiv individuals have worse clinical outcomes and higher mortality risk.Depression is caused by a complex combination of social, psychological, and biological variables.This systematic review, thereby motivated by the need to address this gap in the literature, aims to articulate determinants of depression among msm living with hiv according to the biopsychosocial approach.Methodology we systematically searched four databases from 2011 to 2021.We searched for observational studies on determinants of depression among msm living with hiv.The outcome is depression based on the categorical or numerical outcome.Two reviewers independently extracted data and assessed study risks of bias.Any disagreements are consulted with the third reviewer.Results we identified 533 articles, of which only eight studies are included.A total of 3,172 msms are included in the studies.We found the determinants of depression and categorized them according to biological, psychological, and social approaches.Conclusion the determinants of depression with the strongest evidence across studies were enacted hiv-related stigma, unemployment, sleep disturbance, current smoker, black ethnicity, born overseas, art initiation, and access to mental health care.Despite weaker evidence, the other relevant determinants to be included were older age, internalized stigma, self-efficacy, and social support.Efforts to improve or prevent depression among msm living with hiv could benefit from addressing the determinants of depression based on the biopsychosocial approach immediately after hiv diagnosis.Integrating mental health screening and care into hiv treatment settings would strengthen hiv prevention and care outcomes and improve access to mental healthcare.

Journal: PloS one (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Systematic Review