syedzayyan/paper_mill_benchmark huggingface dataset:
Artesunate Suppresses the Growth of Lung Cancer Cells by Downregulating the AKT/Survivin Signaling Pathway

Nsclc (non‐small‐cell lung cancer) is the deadliest cancer in the world.Artesunate is one of the most potent and rapidly acting antimalarial agents.Recently, emerging evidence has suggested the anticancer function of artesunate.In our work, we aimed to investigate the molecular mechanism of artesunate‐induced growth inhibition in human lung adenocarcinoma cells and reported that the anticancer effects of artesunate is related to its ability in downregulating akt/survivin signaling in a549 cells.The effect of artesunate on the proliferation of a549 cells was determined by cck‐8 assay and colony formation assay; its effect on a549 cell apoptosis was evaluated by lactate dehydrogenase (ldh) release assay.The role of artesunate on the activation of akt/survivin signaling was analyzed by western blot and quantitative qpcr.Finally, we used two mouse tumor models to investigate the function of artesunate on the in vivo growth of lung cancer cells.Artesunate treatment caused significant growth inhibition and apoptosis in a549 cells.Mechanistically, artesunate downregulated the activation of akt/survivin signaling.In agreement, hyperactivation of akt signaling restored artesunate‐induced growth inhibition in a549 cells.In mouse lung cancer models, artesunate administration significantly reduced the growth of a549 cells and llc cells in nude mice and immunocompetent mice, respectively.Our findings suggest that artesunate serves as a potential tumor suppressor in lung cancer and hopefully can provide new insight into the development of therapeutic strategies in the clinical lung cancer treatment.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Application of Visual Artificial Airway in Patients with ARDS Assisted by Pulmonary Ultrasound

To explore the application of pulmonary ultrasound in visual nursing of artificial airway in patients with acute respiratory distress syndrome (ards).Methods .Seventy‐eight ards patients with mechanical ventilation admitted from february 2021 to january 2022 were included and divided into the intervention group and the control group.The control group was given routine airway nursing, and the intervention group was given visual airway nursing management through lung ultrasound.The arterial blood gas analysis indexes, mechanical ventilation time, icu treatment time, total hospitalization time, aspiration, and the incidence of ventilator‐associated pneumonia (vap) were compared between the two groups.Results .After treatment, pa o 2 , pa co 2 , spo 2 , and oxygenation indexes were significantly improved compared with those before treatment, and the indexes in the intervention group were better than those in the control group after treatment, and the differences were statistically significant ( p &lt; 0.05).The mechanical ventilation time (5.39 ± 0.68 vs.7.92 ± 0.59 days), icu treatment time (8.05 ± 1.14 vs.10.71 ± 1.16 days), and total hospitalization time (12.05 ± 2.20 vs.15.68 ± 2.18 days) in the intervention group were significantly shorter than those in the control group ( p &lt; 0.05).The incidences of aspiration (2.56% vs.15.38%) and vap (5.13% vs.20.51%) in the intervention group was significantly lower than that in the control group ( p &lt; 0.05).Conclusion .The application of visual artificial airway management assisted by lung ultrasound in ards patients can shorten the treatment time and hospitalization time of mechanical ventilation, reduce the incidence of aspiration and vap, and improve the prognosis of patients.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Application of Laparoscopy Combined with Enhanced Recovery after Surgery (ERAS) in Acute Intestinal Obstruction and Analysis of Prognostic Factors: A Retrospective Cohort Study

A retrospective cohort study was carried out to research the effect of stent combined with laparoscopy combined with enhanced recovery after surgery (eras) in the operation of acute intestinal obstruction and to explore and analyze the prognostic factors.Methods.During february 2019 to april 2021, sixty patients with acute intestinal obstruction cured in our hospital were enrolled.Randomly assigned control group patients ( n = 50) were divided into the research group and control group patients.The control group accepted stent combined with laparoscopic therapeutic, and the research group accepted stent combined with laparoscopic therapeutic based on eras.The general data, operative index, short form 36 (sf‐36) score, visual analogue scale (vas) score, procalcitonin (pct), crp, prealbumin (pa) index, curative effect, and incidence of complications were investigated.Results.No difference was found in age, gender, or type of disease among the general population ( p &gt; 0.05).A lower amount of blood was lost during the operation, less anal exhaustion was experienced by the research group, and a shorter hospital stay and lower hospitalization cost was experienced in the research group compared to the control group ( p &lt; 0.05).There exhibited no remarkable difference in sf‐36 score and vas score before operation, but after operation, the vas score lessened, the sf‐36 score augmented, while the vas score was lower, and the sf‐36 score in the research group was higher ( p &lt; 0.05).There exited no remarkable difference in the indexes of pct, crp, and pa before operation, but after operation, the levels of pct and crp lessened as well as the level of pa augmented, and the levels of pct and crp were lower, while the level of pa in the research group was higher.In terms of the clinical efficacy, the effective rate of the research group (98.00%) was higher compared to the control (86.00%) ( p &lt; 0.05).The main postoperative complications were pulmonary infection and incision infection.One case of incision infection occurred in the research group, and the probability of postoperative complications was 2.00%.In the control group, there were 3 cases of pulmonary infection, 0 cases of perforation, and 4 cases of incision infection, and the probability of postoperative complications was 14.00%.The prevalence in the research group was remarkably lower ( p &lt; 0.05).Conclusion.Compared with the traditional concept of surgical therapeutic, it can more effectively reduce stress reaction, relieve postoperative pain, promote the recovery of postoperative gastrointestinal function as soon as possible, and reduce postoperative complications, which is worth to explore the application in the therapeutic of acute abdomen.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Application of Fuzzy PID Position Control Algorithm in Motion Control System Design of Palletizing Robot

In view of the low efficiency in traditional palletizing robot problem of poor control precision, this paper introduces fuzzy pid position control algorithm, based on the actual operation situation of palletizing robot; determined as palletizing robot fpga hardware platform, hardware platform based on this fuzzy pid position control algorithm is applied to implement palletizing robot motion control system design.The simulation model of fuzzy pid motion control was established by matlab software for testing to determine that the fuzzy pid position control algorithm reflects the time quickly in the motion control of palletizing robot, and the actual overshooting is small, which is more suitable for the motion control algorithm of palletizing robot.Under this condition, the modular method is adopted to complete the system application design on the fpga hardware platform.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Application of Functional Nanomaterials in Aesthetic Art and Industrial Design Concept

Industrial design (id) refers to industrial product design based on engineering, aesthetics, and economy.Traditional industrial design refers to the creative activities of designing and designing products produced by industrial means to make the best match with the environment and the people who use them.This paper aims to study how to analyze and study the application of aesthetic art, that is, the concept of industrial design, based on functional nanomaterials, and this paper describes the electrospinning technology.This paper puts forward the problem of the industrial design concept, which is based on design aesthetics.Therefore, this paper focuses on the development of industrial design and related elements.The application of functional nanomaterials in industrial design is designed and analyzed.The experimental results show that when the acid soaking time is 4∼12 days, the mechanical strength of the nanofiber membrane is 7∼9 mpa.Compared with the untreated nanofiber membrane, it increased by 25.4%∼48.8%, and the ductility decreased from 81.5% to 44.1%.

Journal: Advances in Materials Science and Engineering (2022)
Publication types: Research Article;
Application of CTU-Assisted Doppler Ultrasound Puncture in Nontube Percutaneous Nephrolithotomy, Its Effect on Patients' Complications, and Its Clinical Value

To research the application of ctu‐assisted doppler ultrasound puncture in uncatheterized pcnl, its influence on patients’ complications, and its clinical value in a case‐control study.Methods .One hundred and forty‐four patients who went through percutaneous nephrolithotomy (pcnl) from march 2019 to june 2021 in our hospital were arbitrarily assigned into the ctu group ( n = 72) and ct plain scan group ( n = 72).Cta+ctu was adopted to determine the puncture passage in the ctu group, and ct scan was employed in the ct group.The intraoperative blood loss, postoperative blood loss, operation time, hospital stay, primary stone removal rate, and the incidence of intraoperative and postoperative complications were compared.The visual analogue score (vas) was employed to assess the degree of postoperative wound pain.Results .The first‐stage stone removal rate in the ctu group was 95.83% (69/72), which was remarkably higher compared to the ct plain scan group, which was 81.94% (59/72), and the difference was statistically significant ( p &lt; 0.05).The overall rates of intraoperative complications were 6.94% (5/72) in the ctu group and 18.06% (13/72) in the ct plain scan group, respectively, which exhibited great differences ( p &lt; 0.05).In addition, the overall rates of intraoperative complications were 2.78% (2/72) in the ctu and 13.89% (10/72) in the ct plain scan group, respectively, and the difference was statistically significant ( p &lt; 0.05).The operation time and postoperative hospital stays in the ctu group were remarkably shorter compared to the ct group, and the difference was statistically significant ( p &lt; 0.05).The intraoperative and postoperative blood loss of ctu group displayed obvious less than that of the ct group, and the difference was statistically significant ( p &lt; 0.05).The vas were compared 24 hours after surgery.After operation, the vas of 24 hours after operation in the ctu group (0.92 ± 0.12) were remarkably lower compared to the ct group (1.22 ± 0.15), and the difference was statistically significant ( p &lt; 0.05).Discussion .Pcnl is constantly being optimized by ctu‐assisted doppler ultrasound puncture to improve stone clearance rates, reduce postoperative bleeding, be less painful, provide rapid recovery, and provide safe and feasible results.It is therefore worthwhile to standardize and then widely promote it in clinical practice.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Application and Analysis of Artificial Intelligence in College Students’ Career Planning and Employment and Entrepreneurship Information Recommendation

With the arrival of graduation season, the number of graduates is expanding every year, and the employment rate of college students has become one of the data that colleges and universities pay attention to.To improve the employment rate of college students, we should first educate each college student in career planning, so that they can clearly understand their own positioning and future development direction.Career planning can guide students to understand their jobs and analyze their professional fields.Faced with massive employment information, it is also a big problem for college students to search and choose information.In this paper, the personalized recommendation system for entrepreneurship is described, and the basic principles of information recommendation are described.The basic information and personal interest points of college students are represented by feature vectors, which provide a favorable theoretical support for college students’ career planning and employment and entrepreneurship information recommendation.An information recommendation model under deep learning is formed.Finally, the performance of the model under the traditional algorithm and the optimized information recommendation model is evaluated, and the satisfaction of users to this system is scored so as to provide a convenient and quick information recommendation system for college students, thus indirectly improving the employment rate of graduates and providing corresponding solutions to the problem of difficult employment.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Analysis of the Structure of Aerobics Complete Sets of Movements Based on Genetic Algorithm

As an independent sport, aerobics is a popular and highly popular sport that integrates group gymnastics, dance, music, fitness, and entertainment.With the continuous development of global fitness fever and happy sports in recent years, the classification of aerobics has become more and more extensive.The development of fitness aerobics and competitive aerobics conforms to the trend of the times.In the course of aerobics teaching, action structure analysis is essential, and the performance of decomposing action image recognition has a direct impact on the effect of aerobics teaching.Therefore, it is important to study an effective aerobics complete set of action structure analysis method.In order to solve the problem that the traditional method is easily affected by the movement rate, lighting conditions, occlusion, complex background, etc., resulting in poor robustness of the recognition results, this paper takes the complete set of aerobics movements as the initial population and then designs the adaptation of the aerobics movements.The degree function is used to realize the structural analysis of aerobics complete sets of movements through the genetic algorithm.First, the video sequence is divided into several segments by using the time energy pyramid, and the human body target for aerobics exercise is extracted by the background subtraction method, and the decomposition actions of aerobics are obtained.By calculating the fitness of different actions, the fitness of the complete set of actions is obtained and then realize the analysis of aerobics complete sets of movements.The structural analysis of aerobics complete sets of movements can not only improve the choreography efficiency of complete sets of movements, but also promote the improvement of the training level of aerobics athletes, and help coaches make relative adjustments and changes in teaching on the basis of the original training of athletes.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Analysis of the Efficacy of Acupuncture Combined with Rehabilitation Training in the Treatment of Upper Limb Spasm after Stroke: A Systematic Review and Meta-Analysis

Systematic evaluation of the efficacy of acupuncture combined with cognitive rehabilitation training in the treatment of upper limb spasm after cerebral apoplexy.Methods .The data of cnki, cbm, cqvip, wanfang, and the libraries of pubmed and cochrane were searched by computer, and the related literatures about acupuncture combined with cognitive rehabilitation training in the treatment of cognitive dysfunction after stroke were searched.The search time is from january 1, 1995 to january 1, 2022.All data segments were independently analyzed and extracted by two evaluators.After evaluating the quality of the methodology, meta‐analysis was carried out by using the rev man5.4 software.Results .Finally, 11 studies were included, with a total of 789 subjects.The results of meta‐analysis indicated that acupuncture combined with cognitive rehabilitation training was superior to simple cognitive rehabilitation training or drugs in the following aspects, the difference exhibited statistically significant, the total effective rate (rr = 1.58, 95% ci), latency of p300 (md = −18.46, 95% ci), amplitude of p300 (md = 1.23, 95% ci (0.82), p &lt; 0.00001, 95% ci (0.31)), and activity of daily living (adl), respectively, were significantly higher compared to the control group ( p &lt; 0.00001), and the difference was statistically significant ( p &lt; 0.05).Based on the results of systematic evaluation, the grade system recommendation classification method is used to evaluate the quality of evidence.The results show that the level of evidence is low and the intensity of recommendation is weak.Conclusion .The results of this meta‐analysis suggest that the curative effect of acupuncture combined with cognitive rehabilitation training is better compared to simple cognitive rehabilitation training or drugs.However, due to the low quality of the original literature, it needs to be confirmed by multicenter, high‐quality, large‐sample randomized blind controlled trials in the future.

Journal: BioMed Research International (2022)
Publication types: Meta-Analysis;
Analysis of the Diagnostic Efficacy of DOTATATE Imaging Combined with CGA and BSP Detection Mode for NEN Patients with Bone Metastasis

In order to explore the clinical efficacy of dotatate imaging combined with cga and bsp in the diagnosis of bone metastasis in patients with nens, a total of 100 nen patients treated in our hospital from january 2021 to january 2022 were analyzed.All patients are divided into bone metastasis group and nonmetastasis group according to pathological examination results.The differences of dotatate imaging, cga, and bsp are compared, and roc curves are obtained to analyze the clinical efficacy of the three indicators in single application and combined diagnosis.The results show that auc, sensitivity, and specificity of dotatate, bsp, and cga combined diagnosis are higher than those of single diagnosis ( p &lt; 0.05).It is clearly evident that dotatate test, bsp, and cga can obtain accurate results in the diagnosis of bone metastasis in nen patients, and those combined diagnosis can improve the diagnostic efficiency.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Analysis of Risk Factors of Coronary Heart Disease and Its Correlation with Inflammatory Factors in Patients with Type 2 Diabetes Mellitus

In this paper, we propose a new method to analyze the risk factors of coronary heart disease (chd) and their correlation with inflammatory factors in patients with type 2 diabetes mellitus (t2dm).To verify and implement this idea, we have selected a total of 165 patients with t2dm treated in our hospital from march 2019 to october 2021 that were divided into chd group ( n = 72) and non‐chd group ( n = 93) according to the results of coronary angiography.Patients with chd were divided into three groups according to syntax score: low‐risk group, medium‐risk group, and high‐risk group.The clinical data of all patients were collected.Univariate and multivariate analyses were used to screen the risk factors of chd in patients with t2dm.The related inflammatory factors such as c‐reactive protein (crp), interleukin‐6 (il‐6), and water‐soluble cd40 ligand (s cd40l) were detected in all patients.Pearson’s linear correlation analysis was used to analyze the correlation between the expression levels of crp, il‐6, and s cd40l and chd in patients with t2dm.The receiver working curve (roc) was used to evaluate the efficacy of il‐6, crp, and s cd40l in predicting high risk of chd in patients with t2dm.Multivariate analysis showed that age and course of t2dm, ffa, ua, and hcy were risk factors for chd in patients with t2dm.The serum levels of il‐6, crp, and s cd40l in patients with chd were significantly higher than those in patients without chd.According to syntax score, 72 patients with chd were divided into low‐risk group ( n = 36), medium‐risk group ( n = 26), and high‐risk group ( n = 10).Compared with the low‐risk group, the expression levels of serum il‐6 crp and s cd40l in the middle‐risk group and high‐risk group were significantly higher than those in the low‐risk group.The expression levels of il‐6 crp and s cd40l in the high‐risk group were also significantly higher than those in the medium‐risk group.There is a positive correlation between syntactic score and il‐6 expression in patients with t2dm complicated with coronary heart disease ( r = 0.778, p &lt; 0.001), with the expression of crp ( r = 0.756, p &lt; 0.001) and with the expression of s cd40l ( r = 0.748, p &lt; 0.001).Advanced age, long course of t2dm, elevated levels of ffa, ua, and hcy are all risk factors of chd in patients with type 2 diabetes.T2dm patients with the above risk factors should be vigilant and pay attention to monitoring the related indexes of coronary heart disease to avoid the occurrence of serious cardiovascular disease.Crp, il‐6, and s cd40l are involved in the progression of chd in patients with t2dm.The more severe chd is, the higher the expression of il‐6, crp, and s cd40l in serum.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Analysis of Bank Customer Default Risk Based on Embedded Microprocessor Wireless Communication

Bank personal credit is affected by factors such as inadequate management and lagging risk information management system.Bank default risk analysis is needed to improve the ability of bank credit risk management.Therefore, a bank customer default risk analysis based on embedded microprocessor wireless communication is proposed.Firstly, it analyzes the risk assessment parameter evaluation system of personal credit, constructs the quantitative analysis model of personal credit risk, calculates the grade gradient value in the bank’s personal credit risk standard, carries out the mathematical modeling of bank customer default risk assessment, strengthens the implementation of “three checks,” tracks and manages the borrower, supervises the use of credit funds, improves the social credit investigation system, and on this basis, optimizes the mathematical model of bank customer default risk assessment.The experimental results show that this method can realize the bank’s quantitative evaluation and control of personal credit risk, improve the bank’s credit risk prevention and control ability, and provide a reliable basis for the bank’s credit risk evaluation operation and management.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;