syedzayyan/paper_mill_benchmark huggingface dataset:
The inhibitory effect of Gualou Guizhi Decoction on post-ischemic neuroinflammation via miR-155 in MCAO rats.

Gualou guizhi decoction (glgzd) is commonly used to treat stroke.The present study investigated the potential roles of glgzd on inflammation involving micro rna-155 (mi r-155) in a model of ischemic stroke using middle cerebral artery occlusion (mcao) rats.Methods sprague-dawley rats were randomly divided into three groups: sham operated group, mcao model group, and glgzd treatment group.The ischemic model was established by 2 h left mcao followed by reperfusion.Neurological deficits were evaluated with a modified ashworth scale in each group.The changes in individual paw parameters were assessed by catwalk gait analysis.Inflammatory cytokines were measured by enzyme linked immunosorbent assay (elisa) and protein levels and gene expression related to inflammation were detected by western blot and quantitative reverse transcription-pcr (q rtpcr) assays, respectively.The expression of inflammatory signaling proteins was additionally detected by immunohistochemistry.Results treatment of mcao rats with glgzd improved neuronal defects and limb motivity.Additionally, glgzd was able to inhibit mi r-155 upregulation, resulting in down-regulation of mi r155-targeted molecules in mcao rats, including suppressor of cytokine signaling 1 (socs1), inhibitor of nuclear factor kappa-b kinase (ikk), mothers against decapentaplegic homolog 2 (smad2) and ccaat/ enhancer binding protein beta (cebpβ).Meanwhile, the production of anti-inflammatory cytokines was dramatically enhanced by glgzd treatment when comparing with the mcao model group.Conclusions in conclusion, glgzd down-regulates mi r-155, mediating subsequent neuroinflammation and resulting in neuroprotection which contributes to reduced spasticity after ischemic stroke.

Journal: Annals of palliative medicine (2021)
Publication types: Journal Article
Lazily Aggregated Quantized Gradient Innovation for Communication-Efficient Federated Learning.

This paper focuses on communication-efficient federated learning problem, and develops a novel distributed quantized gradient approach, which is characterized by adaptive communications of the quantized gradients.Specifically, the federated learning builds upon the server-worker infrastructure, where the workers calculate local gradients and upload them to the server; then the server obtain the global gradient by aggregating all the local gradients and utilizes it to update the model parameter.The key idea to save communications from the worker to the server is to quantize gradients as well as skip less informative quantized gradient communications by reusing previous gradients.Quantizing and skipping result in 'lazy' worker-server communications, which justifies the term lazily aggregated quantized (laq) gradient.Theoretically, the laq algorithm achieves the same linear convergence as the gradient descent in the strongly convex case, while effecting major savings in the communication in terms of transmitted bits and communication rounds.Empirically, extensive experiments using realistic data corroborate a significant communication reduction compared with state-of-the-art gradient- and stochastic gradient-based algorithms.

Journal: IEEE transactions on pattern analysis and machine intelligence (2022)
Publication types: Journal Article
Basic Psychological Needs Satisfaction Mediates the Link between Strengths Use and Teachers' Work Engagement.

Work engagement is a core indicator that reflects the quality of teachers' occupational lives and the development of students, but few studies have explored the connection between strengths use and work engagement of teachers and the mechanisms underlying this relationship.This paper aimed to investigate how the relation of strengths use with work engagement is affected by a teacher's satisfaction of basic psychological needs.For this purpose, 648 teachers in china completed questionnaires.The results revealed that strengths use exhibited a positive correlation with work engagement and needs satisfaction.Furthermore, autonomy, competence, and relatedness satisfaction mediated the effect of strengths use on work engagement for teachers.The results suggest that autonomy, competence, and relatedness satisfaction serve as factors that mediate the effect of strengths use on work engagement.The significance and limitations of the study are discussed.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Can frozen-thawed human ovary withstand refreezing-rethawing in the form of cortical strips?

The aim of this study was to elucidate whether ovarian tissue is able to withstand a double freezing-thawing procedure.Methods human ovarian cortical biopsies from 4 thawed whole ovaries were divided into 4 experimental subgroups: (a) frozen-thawed non-grafted group, (b) frozen-thawed xenografted group, (c) refrozen-rethawed non-grafted group, and (d) refrozen-rethawed xenografted group.Xenografting was performed using 8 severe combined immunodeficient mice for a total duration of 21 days.The following analyses were conducted: classic hematoxylin and eosin staining, ki67 immunolabeling, transmission electron microscopy, masson's green trichrome, and double cd34 immunostaining.Results morphologically normal preantral follicles were detected in all groups.We observed a dramatic decline of more than 65% in early preantral follicle survival rates after grafting of both frozen-thawed (p < 0.0001) and refrozen-rethawed (p < 0.0001) ovarian tissue.However, mean follicle densities remained comparable between the frozen-thawed and refrozen-rethawed non-grafted groups, as well as both grafted groups.Equivalent proportions of proliferating early preantral follicles were identified in frozen-thawed and refrozen-rethawed samples, whether the tissue was grafted or not.Furthermore, we did not observe any significant difference in atretic follicle rates between any of the four groups, and the ultrastructural quality of follicles appeared unaffected by the refreezing procedure.Similar proportions of fibrosis were noted in the frozen-thawed and refrozen-rethawed groups, irrespective of grafting.Finally, no significant differences were witnessed in terms of vascularization.Conclusion we were able to demonstrate, for the first time, that refrozen-rethawed ovarian tissue has the same functional characteristics as frozen-thawed ovarian tissue.

Journal: Journal of assisted reproduction and genetics (2020)
Publication types: Journal Article
Revisiting Jerusalem Syndrome: A Case Displaying Similar Symptoms to Jerusalem Syndrome During Mecca Visit.

Jerusalem syndrome is a mental illness rarely seen in people who visit jerusalem, manifests itself with obsessive religious thoughts, delusions, psychotic symptoms, and some characteristic features.In clinical practice, it's uncommon to encounter patients displaying symptoms of the jerusalem syndrome.In this paper, we report a case of a middle-aged woman who manifested psychiatric symptoms similar to the jerusalem syndrome after a mecca visit without any previous psychiatric history.After careful examination, religious delusions, auditory and visual hallucinations, racing thoughts, disorganized speech, and confusion were denoted, therefore the patient was hospitalized.Brain imaging and laboratory examination was unremarkable.After nine days of antipsychotic treatment, the patient's symptoms completely dissolved, and she was discharged.Antipsychotic treatment was ceased entirely after two months.The patient and her family members reported that the patient was symptom-free for the following two years.Keywords: brief reactive psychosis, religion, travel, differential diagnosis.

Journal: Turk psikiyatri dergisi = Turkish journal of psychiatry (2022)
Publication types: Case Reports;Journal Article
Comparative genome anatomy reveals evolutionary insights into a unique amphitriploid fish.

Triploids are rare in nature because of difficulties in meiotic and gametogenic processes, especially in vertebrates.The carassius complex of cyprinid teleosts contains sexual tetraploid crucian carp/goldfish (c.Auratus) and unisexual hexaploid gibel carp/prussian carp (c.Gibelio) lineages, providing a valuable model for studying the evolution and maintenance mechanism of unisexual polyploids in vertebrates.Here we sequence the genomes of the two species and assemble their haplotypes, which contain two subgenomes (a and b), to the chromosome level.Sequencing coverage analysis reveals that c.Gibelio is an amphitriploid (aaabbb) with two triploid sets of chromosomes; each set is derived from a different ancestor.Resequencing data from different strains of c.Gibelio show that unisexual reproduction has been maintained for over 0.82 million years.Comparative genomics show intensive expansion and alterations of meiotic cell cycle-related genes and an oocyte-specific histone variant.Cytological assays indicate that c.Gibelio produces unreduced oocytes by an alternative ameiotic pathway; however, sporadic homologous recombination and a high rate of gene conversion also exist in c.Gibelio.These genomic changes might have facilitated purging deleterious mutations and maintaining genome stability in this unisexual amphitriploid fish.Overall, the current results provide novel insights into the evolutionary mechanisms of the reproductive success in unisexual polyploid vertebrates.

Journal: Nature ecology & evolution (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Ophthalmic artery resistance index after peribulbar block in the presence of epinephrine.

There are controversies regarding ophthalmic artery (oa) flow after peribulbar block in the presence of epinephrine.Therefore, we aimed to evaluate oa flow via echo-doppler before and after peribulbar block with lidocaine in the presence or absence of epinephrine.Methods fifty-six patients who had an american society of anesthesiologists (asa) classification of i, ii or iii and were eligible for cataract phacoemulsification surgery were selected.Patients with other eye diseases were excluded.Patients were divided into two groups: group 1-peribulbar block with lidocaine and 1/200,000 epinephrine; group 2-peribulbar block with lidocaine in the absence of epinephrine.The resistance index (ri), peak systolic velocity (psv), end diastolic velocity (edv) of the oa were evaluated using echo-doppler before and 10 min after the peribulbar block.Results no differences between groups were observed in the ri before the peribulbar block as well regarding the presence of hypertension and the age or gender of the patient.After the peribulbar block, we observed a decrease in the ri in group 1 (p = 0.038, cohen's d = 0.336) and no difference in the ri in group 2 (p = 0.109, cohen's d = 0.172).When comparing group 1 and group 2, we observed a decrease in the ri in group 1 (p = 0.028, cohen's d = 0,583).There was no difference between groups regarding the psv and edv after the peribulbar block.Conclusions a decrease in ri was observed in the oa after peribulbar block with a vasoconstrictor, an effect that could be a benefit in some ocular surgeries.

Journal: International ophthalmology (2021)
Publication types: Journal Article
Targeted Treatment for High-Risk Early-Stage Triple-Negative Breast Cancer: Spotlight on Pembrolizumab.

Triple-negative breast cancer (tnbc) is a biologically aggressive yet heterogeneous disease that disproportionately affects younger women and women of color compared to other breast cancer subtypes.The paucity of effective targeted therapies and the prevalence of chemotherapeutic resistance in high-risk, early-stage tnbc pose significant clinical challenges.Deeper insights into the genomic and immune landscape have revealed key features of tnbc, including intrinsic genomic instability, dna repair deficiency, and potentially an immunogenic tumor microenvironment.These advances led to landmark trials with immune checkpoint inhibitors in the advanced-stage setting, which subsequently translated into immunotherapy-based clinical trials in the early-stage setting and recent promising results.Pembrolizumab, an anti-programmed death 1 (pd-1) monoclonal antibody, was investigated in combination with platinum-, taxane- and anthracycline-based neoadjuvant chemotherapy followed by adjuvant pembrolizumab monotherapy for patients with high-risk, early-stage tnbc in the randomized, double-blind, placebo-controlled phase 3 keynote-522 trial.In july 2021, the us food and drug administration (fda) granted approval for pembrolizumab based on marked improvement in pathologic complete response rate and 3-year event-free survival compared to neoadjuvant chemotherapy alone.This advance immediately altered the longstanding treatment paradigm.Here, we review the impact of pembrolizumab plus chemotherapy for the treatment of patients with high-risk, early-stage tnbc, and discuss immunotherapy-related toxicity considerations, key immunomodulatory biomarkers under active investigation, and remaining clinical questions for future research directions.

Journal: Breast cancer (Dove Medical Press) (2022)
Publication types: Journal Article;Review
Improvement of Oral Bioavailability and Anti-Tumor Effect of Zingerone Self-Microemulsion Drug Delivery System.

This study sought to prepare a self-microemulsion drug delivery system containing zingerone (z-smedds) to improve the low oral bioavailability of zingerone and anti-tumor effect.Z-smedds was characterized by particle size, zeta potential and encapsulation efficiency, while its pharmacokinetics and anti-tumor effects were also evaluated.Z-smedds had stable physicochemical properties, including average particle size of 17.29 ± 0.07 nm, the zeta potential of -22.81 ± 0.29 m v, and the encapsulation efficiency of 97.96% ± 0.02%.In vitro release studies have shown the release of zingerone released by z-smedds was significantly higher than free zingerone in different release media.The relative oral bioavailability of z-smedds was 7.63 times compared with free drug.Meanwhile, the half inhibitory concentration (ic50)of z-smedds and free zingerone was 8.45 μg/m l and 13.30 μg/m l, respectively on hep g2.This study may provide a preliminary basis for further clinical research and application of z-smedds.

Journal: Journal of pharmaceutical sciences (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Large area stimulated emission luminescent solar concentrators modelled using detailed balance consistent rate equations.

Stimulated emission luminescent solar concentrators (selscs) have the potential to reduce escape cone losses in luminescent solar concentrators (lscs).However, a functional selsc is yet to be demonstrated.Previous numerical studies and detailed balance limits provide guidance, but they also contradict and likely overestimate performance and underestimate requirements.In this work, we introduce a rate-equation model with inversion requirements compatible with detailed balance limits and apply this model to the numerical modelling of window-sized selscs.We find that the optimal pump photon energy for both lscs and selscs is 1.35 e v and the potential improvement of selscs over lscs is found to be 19.3%.The efficiencies found are much lower than those specified in previous work due to the increase in stokes shift required for a highly luminescent material.We also find that selscs are more attractive at higher matrix losses, that emission linewidths <0.05 e v are desirable, and that selsc devices can potentially achieve performance equal to lscs at low illumination levels and simultaneously exceed it by up to 16.5% at 1-sun illumination.

Journal: Optics express (2022)
Publication types: Journal Article
SIGLEC1 (CD169): a marker of active neuroinflammation in the brain but not in the blood of multiple sclerosis patients.

We aimed to evaluate siglec1 (cd169) as a biomarker in multiple sclerosis (ms) and neuromyelitis optica spectrum disorder (nmosd) and to evaluate the presence of siglec1+myeloid cells in demyelinating diseases.We performed flow cytometry-based measurements of siglec1 expression on monocytes in 86 ms patients, 41 nmosd patients and 31 healthy controls.Additionally, we histologically evaluated the presence of siglec1+myeloid cells in acute and chronic ms brain lesions as well as other neurological diseases.We found elevated siglec1 expression in 16/86 (18.6%) ms patients and 4/41 (9.8%) nmosd patients.Almost all ms patients with high siglec1 levels received exogenous interferon beta as an immunomodulatory treatment and only a small fraction of ms patients without interferon treatment had increased siglec1 expression.In our cohort, siglec1 expression on monocytes was-apart from those patients receiving interferon treatment-not significantly increased in patients with ms and nmosd, nor were levels associated with more severe disease.Siglec1+myeloid cells were abundantly present in active ms lesions as well as in a range of acute infectious and malignant diseases of the central nervous system, but not chronic ms lesions.The presence of siglec1+myeloid cells in brain lesions could be used to investigate the activity in an inflammatory cns lesion.

Journal: Scientific reports (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Prognostic Impact of Post-Diagnosis Smoking Cessation among Bladder Cancer Patients: A Systematic Literature Review and Meta-Analysis.

We reviewed the studies examining whether quitting smoking at or around diagnosis favourably affects the prognosis of bladder cancer (bc) patients, who are often active smokers at diagnosis.We found only nine eligible articles published until 31 january 2022, which encompassed around 5500 bc in total, the majority of which were nonmuscle invasive bc (only one paper included muscle-invasive bc).We used random effects meta-analysis to obtain a summary hazard ratio (shr) and 95% confidence intervals (ci).The median proportion of smokers who quit at or around diagnosis was 29.8% (range 8.4-43.1%).For the overall, bc-specific, and progression-free survival, the studies were limited in number (n= 3) and provided conflicting results.At the same time, quitters did not appear to have a lower risk of recurrence than continued smokers (shr 0.99, 95% ci 0.61-1.61).In conclusion, while the evidence is currently not sufficient to draw firm conclusions (especially for patients with muscle-invasive bc), physicians should not refrain from educating smoking bc patients about the benefits of smoking cessation and provide the necessary support.

Journal: Cancers (2022)
Publication types: Journal Article;Review
Heterologous Prime-Boost Immunization with DNA Vaccine and Modified Recombinant Proteins Enhances Immune Response againstTrueperella pyogenesin Mice.

Trueperella pyogenes(t.Pyogenes) is a crucial opportunistic pathogen normally causing mastitis, abscesses and pneumonia in economically important ruminants.Although only one commercial vaccine of t.Pyogenesis currently obtainable, its immunoprotective effect is limited.Pyolysin (plo) is the most predominant virulence factor highly expressed in t.Pyogenesand is an excellent target for the development of novel vaccines against t.Pyogenes.In this study, we designed a heterologous prime-boost vaccination scheme combining a dna vaccine p vax1-plo and a subunit vaccine his-plo to maximize host responses in mice.Humoral and cellular immune responses and protective effects were evaluated in mice to compare the immunogenicity induced by different immunization schemes.Compared to the pbs-control group, in vivo immunization results showed that better immune responses of mice immunized with the p vax1-plo plasmids and his-plo proteins were induced.The residual bacterial burdens from the liver and peritoneal fluid were remarkably decreased in the immunized mice compared with the pbs group.Notably, the heterologous prime-boost vaccination groups significantly enhanced host humoral and cellular immune responses and protected mice from different virulent t.Pyogenesstrains infection.Conclusively, this study provides a favorable strategy for the further development of next-generation vaccines against t.Pyogenesinfections.

Journal: Vaccines (2022)
Publication types: Journal Article
Comparative Performance of Fungicides, Biofungicides, and Host Plant Defense Inducers in Suppression of Phytophthora Root Rot in Flowering Dogwood During Simulated Root Flooding Events.

During flooding events in nurseries, phytophthora root rot caused by phytophthora cinnamomi rands often causes damage that leads to complete crop loss.In this study, we evaluated the efficacy of fungicides, biofungicides, and host plant defense inducers for preventive and curative control of phytophthora root rot on flowering dogwood (cornus florida l.) seedlings exposed to a simulated flood event of 1, 3, or 7 days.In two greenhouse trials, preventive (7 days before flooding) or curative (1 day after flooding) drench treatments were applied to dogwood seedlings artificially inoculated with p.cinnamomi.The plants were flooded by maintaining standing water for 1, 3, or 7 days.After the trials, plant growth data (total plant weight, root weight, plant height, and plant width) were recorded, and root systems were assessed for disease severity using a scale of 0 to 100% of roots affected, and subsamples were plated on parph-v8 medium to determine the percent recovery of the phytophthorapathogen.Plants preventively treated with subdue maxx had reduced disease severity relative to the nontreated, inoculated plants (positive control) flooded 1, 3, or 7 days in both trials.Pageant intrinsic and segovis treatments also had lower disease severity than the positive control at all flooding durations in trial two, but not trial one.In trial one, preventive and curative treatments of orkestra intrinsic had reduced disease severity compared with the positive control at 1 and 3 days of flooding, whereas curative treatments of empress intrinsic and tartan stressgard also were effective at 1 and 3 days of flooding in trial one.The host plant defense inducers (aliette 80 wdg, signature xtra, and actigard) were inconsistent and ineffective at reducing disease severity when applied as preventive or curative treatments.Preventive treatments of the biofungicides root shield plus+and mbi-110 had consistently lower disease severity than the positive control at 1 day of flooding but not 3 or 7 days of flooding.Potentially, growers can use information from this study to manage phytophthora root rot during flooding or in areas of the nursery that often experience high soil moisture levels.

Journal: Plant disease (2019)
Publication types: Journal Article