syedzayyan/paper_mill_benchmark huggingface dataset:
Passive Wi-Fi monitoring in the wild: a long-term study across multiple location typologies.

In this paper, we present a systematic analysis of large-scale human mobility patterns obtained from a passive wi-fi tracking system, deployed across different location typologies.We have deployed a system to cover urban areas served by public transportation systems as well as very isolated and rural areas.Over 4 years, we collected 572 million data points from a total of 82 routers covering an area of 2.8 km2.In this paper we provide a systematic analysis of the data and discuss how our low-cost approach can be used to help communities and policymakers to make decisions to improve people's mobility at high temporal and spatial resolution by inferring presence characteristics against several sources of ground truth.Also, we present an automatic classification technique that can identify location types based on collected data.

Journal: Personal and ubiquitous computing (2022)
Publication types: Journal Article
Exposome mapping in chronic respiratory diseases: the added value of digital technology.

Of review the development and progression of chronic respiratory diseases are impacted by a complex interplay between genetic, microbial, and environmental factors.Here we specifically summarize the effects of environmental exposure on asthma, allergic rhinitis, and chronic rhinosinusitis.We furthermore discuss how digital health technology may aid in the assessment of the environmental exposure of patients and how it may be of added value for them.Recent findings it is well established that one gets allergic symptoms if sensitized and exposed to the same allergen.Viruses, bacteria, pollutants, irritants, and lifestyle-related factors modify the risk of getting sensitized and develop symptoms or may induce symptoms themselves.Understanding these processes and how the various factors interact with each other and the human body require big data and advanced statistics.Mobile health technology enables integration of multiple sources of data of the patients' exposome and link these to patient outcomes.Such technologies may contribute to the increased understanding of the development of chronic respiratory disease.Summary implementation of digital technologies in clinical practice may in future guide the development of preventive strategies to tackle chronic respiratory diseases and eventually improve outcomes of the patient.

Journal: Current opinion in allergy and clinical immunology (2022)
Publication types: Journal Article;Review
The Singularity Paramagnetic Peak of Bi0.3Sb1.7Te3with p-type Surface State.

The magnetization measurement was performed in the bi0.3sb1.7te3single crystal.The magnetic susceptibility revealed a paramagnetic peak independent of the experimental temperature variation.It is speculated to be originated from the free-aligned spin texture at the dirac point.The arpes reveals that the fermi level lies below the dirac point.The fermi wavevector extracted from the de haas-van alphen oscillation is consistent with the energy dispersion in the arpes.Our experimental results support that the observed paramagnetic peak in the susceptibility curve does not originate from the free-aligned spin texture at the dirac point.

Journal: Nanoscale research letters (2022)
Publication types: Journal Article
The influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for adolescents and adults with bipolar disorder: A systematic review and meta-analysis.

The influence of childhood trauma on the treatment outcomes of pharmacological and/or psychological interventions for adolescents and adults with bipolar disorder was systematically reviewed.Methods randomised and non-randomised studies of interventions for bipolar disorder that included an assessment of childhood trauma were eligible.Medline complete, embase, psyc info, and the cochrane central register of controlled trials were searched.Two independent reviewers completed the screening and extraction process.Two independent reviewers assessed the risk of bias in the included studies using the cochrane collaboration's risk of bias tool and the newcastle-ottawa scale.Alongside a narrative synthesis, random-effects meta-analyses were performed.Results twelve studies (1175 participants) were included.The narrative review highlighted differential treatment outcomes among individuals with a history of childhood trauma.The meta-analyses suggested that childhood trauma was unrelated to treatment response (five studies, 426 participants; odds ratio 0.58, 95% ci 0.27-1.25, p = .164) but may be associated with greater improvement in global functioning (three studies, 210 participants; hedge's g 0.65, 95% ci 0.04-1.26, p = .037).Limitations the impact of childhood trauma on the effectiveness of specific pharmacological/psychological interventions could not be explored due to the small body of research identified.Conclusion the overall quality of the extant evidence is low, which precludes definitive comment on the role of childhood trauma in the treatment of bipolar disorder.Additional research that uses large and representative samples is required to ascertain whether a history of childhood trauma affects the treatment outcomes of interventions for individuals with bipolar disorder.

Journal: Journal of affective disorders (2022)
Publication types: Journal Article;Meta-Analysis;Research Support, Non-U.S. Gov't;Review;Systematic Review
Low temperature combined with high inoculum density improves alpha-linolenic acid production and biochemical characteristics of Chlamydomonas reinhardtii.

Chlamydomonas reinhardtii grows fast and is rich in polyunsaturated fatty acids.To explore whether the alpha-linolenic acid (ala) content can be further enhanced, the cultures were incubated under different culture temperatures, light intensities and inoculum densities.Results showed that temperature exhibited more great impact on ala synthesis of c.Reinhardtii than light intensity and inoculum size.The changes of light intensity and inoculum size displayed non-significant effects on ala content.The optimal ala proportion in cells was obtained under the condition of 10 °c, 50 μe/m2/s and 5% inoculum density, which reached ∼ 39%.the augmented initial inoculum density could markedly improve the biomass of c.Reinhardtii under 10 °c.The maximum ala productivity (16.42 mg/l/d) was gained under 10 °c coupled with 25% inoculum size, where higher intracellular sugar and protein yield were observed.These results suggest c.Reinhardtii would be an alternative feedstock for the industrial production of ala.

Journal: Bioresource technology (2022)
Publication types: Journal Article
Exploring the associations between behavioral health risk factors, abnormal eating attitudes and socio-demographic factors among Chinese youth: Survey of 7,984 vocational high school students in Hunan in 2020.

This study investigated the associations between behavioral health risk factors (anxiety, depression, stress, insomnia, drinking, smoking) and abnormal eating attitudes among chinese vocational high school students (cvhss).Potential moderating relationships were also explored with relevant socio-demographic factors of the student's age, sex, rural or urban community, household income, family type and educational level of the father and mother.Methods a total of 7,984 students from three vocational high schools in hunan, china completed a questionnaire about their socio-demographic characteristics, alcohol use, smoking, and symptoms of depression, anxiety, stress (21-item version of the depression anxiety stress scale), insomnia (8-item athens insomnia scale), and abnormal eating attitudes (19-item chinese version of eating attitudes test).Results the prevalence rates for behavioral health problems among these students ranged widely depending on the risk factor: 42.5% insomnia, 41.3% anxiety, 26.2% depression, 14.4% stress, 13.7% drinking, and 8.3% smoking.Additionally, 61.7% of students were at-risk for at least one of these six behavioral health disorders.Abnormal eating attitudes were associated with depression (r= 0.422), anxiety (r= 0.490), stress (r= 0.490), and insomnia (r= 0.375), with all of these relationships being significant (p< 0.01) and large size statistical effects.However, other analyzes found that none of the socio-demographic background factors had meaningful associations with the behavioral health risk factors (0 of 28 tests) and very few background factors were associated with the abnormal eating attitude measures (only 3 of 35 tests).Females had higher levels than males on dieting and bulimia but not on the other two eating attitude components.Conclusions this study determined that behavioral health risk factors (sleep problems and anxiety in particular) were common among high school students in china and that mental health and sleep disorder risks also tended to co-occur in some students with abnormal eating attitudes.Therefore, prevention and early identification programs for behavioral risk factors are needed for this population.It is important to pay more attention to students with abnormal eating attitude-related symptoms, who may have also underlying mental health problems and need further evaluation.

Journal: Frontiers in psychiatry (2022)
Publication types: Journal Article
Using publicly available datasets to identify population-based transcriptomic landscape contributing to the aggressiveness of breast cancer in young women.

Introduction:although the risk of breast cancer increases with advancing age, some regions have larger number of young breast cancer patients (≤45 years-old), such as the middle east, eastern asia, and north africa, with more aggressive and poorly differentiated tumors.We aimed to conduct anin-silicoanalysis in an attempt to understand the aggressive nature of early-onset breast cancer, and to identify potential drivers of early-onset breast cancer using gene expression profiling datasets in a population-dependent manner.methods:functional genomics experiments data were acquired from c bio portal database for cancer genomics, followed by the stratification of patients based on the age at representation of breast cancer and race.Differential gene expression analysis and gene amplification status analysis were carried out, followed by hub gene, transcription factor, and signalling pathway identification.results:pam50 subtype analysis revealed that young patients (≤45 years-old) had four-fold more basal tumors and worst progression-free survival (median of 101 months), compared with the 45-65 years group (median of 168 months).Fourteen genes were amplified in more than 14% of patients with an early-onset breast cancer.Interestingly, frem2, linc00332, and linc00366 were exclusively amplified in younger patients.Gene expression data from three different populations (asian, white, and african) revealed a unique transcriptomic profile of young patients, which was also reflected on the pam50 subtype analysis.Our data indicates a higher tendency of young african patients to develop basal tumors, while young asian patients are more prone to developing luminal a tumors.Most genes that were found to be upregulated in younger patients are involved in important signaling pathways that promote cancer progression and metastasis, such as mapk pathway, reelin pathway and the pi3k/akt pathway.conclusion:this study provides strong evidence that the molecular profile of tumors derived from young breast cancer patients of different populations is unique and may explain the aggressiveness of these tumors, stressing the need to conduct population- based multi-omic analyses to identify the potential drivers for tumorigenesis and molecular profiles of young breast cancer patients.

Journal: Frontiers in genetics (2022)
Publication types: Journal Article
Clinical evaluation of a novel subcutaneous lactate monitor.

Lactate levels are commonly used as an indirect measure to assess metabolic stress in clinical conditions like sepsis.Dynamic lactate measurements are recommended to assess and guide treatment in patients with shock and other critical care conditions.A minimally invasive, continuous lactate monitor has potential to improve clinical decisions and patient care.The purpose of the study was to evaluate continuous lactate measurements of a novel enzymatic continuous lactate monitor (clm) developed in our laboratory.Lactate levels were monitored during incremental cycling exercise challenges as a tool for hyperlactatemia.Six healthy individuals 18-45 y/o (4 males, 2 females) participated in the study.Clm devices were inserted subcutaneously in the postero-lateral trunk below the renal angle, one hour before the exercise challenge.Each exercise challenge consisted of a 3 to 12-min warm up period, followed by up to 7, 4-min incremental workload bouts separated by rest intervals.Continuous lactate measurements obtained from clm were compared with commercial lactate analyzer (abbott i stat) measurements of venous blood (plasma) drawn from the antecubital vein.Blood was drawn at up to 25 time points spanning the duration of before exercise, during exercise, and up to 120 min post exercise.Area under the curve (auc), and delay time were calculated to compare the clm readings with plasma lactate concentration.Average plasma lactate concentration increased from 1.02 to 16.21 m m.Ratio of auc derived from clm to plasma lactate was 1.025 (0.990-1.058).Average dynamic delay time of clm to venous plasma lactate was 5.22 min (2.87-10.35).Insertion sites examined 48 h after clm removal did not show signs of side effects and none required medical attention upon examination.The newly developed clm has shown to be a promising tool to continuously measure lactate concentration in a minimally invasive fashion.Results indicate the clm can provide needed trends in lactate over time.Such a device may be used in the future to improve treatment in clinical conditions such as sepsis.

Journal: Journal of clinical monitoring and computing (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Daylight savings time transitions and risk of out-of-hospital cardiac arrest: An interrupted time series analysis.

Many studies have reported increases in the risk of acute cardiovascular events following daylight savings time (dst) transitions.We sought to investigate the effect of dst transition on the incidence of out-of-hospital cardiac arrest (ohca).Methods between january 2000 and december 2020, we performed an interrupted time series analysis of the daily number of ohca cases of medical aetiology from the victorian ambulance cardiac arrest registry.The effect of dst transition on ohca incidence was estimated using negative binomial models, adjusted for temporal trends, population growth, and public holidays.Results a total of 89,409 adult ohca of medical aetiology were included.Following the spring dst transition (i.e.Shorter day), there was an immediate 13% (irr 1.13, 95% ci: 1.02, 1.25; p = 0.02) increased risk of ohca on the day of transition (sunday) and the cumulative risk of ohca remained higher over the first 2 days (irr 1.17, 95% ci: 1.02, 1.34; p = 0.03) compared to non-transitional days.Following the autumn dst transition (i.e.Longer day), there was a significant lagged effect on the tuesday with a 12% (irr 0.88, 95% ci: 0.77, 0.99; p = 0.04) reduced risk of ohca.The cumulative effect following the autumn dst transition was also significant, with a 30% (irr 0.70, 95% ci: 0.51, 0.96; p = 0.03) reduction in the incidence of ohca by the end of the transitional week.Conclusion we observed both harmful and protective effects from dst transitions on the risk of ohca.Strategies to reduce this risk in vulnerable populations should be considered.

Journal: Resuscitation (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The Analgesic Properties ofCorydalis yanhusuo.

Corydalis yanhusuoextract (yhs) has been used for centuries across asia for pain relief.The extract is made up of more than 160 compounds and has been identified as alkaloids, organic acids, volatile oils, amino acids, alcohols, and sugars.However, the most crucial biological active constituents of yhs are alkaloids; more than 80 have been isolated and identified.This review paper aims to provide a comprehensive review of the phytochemical and pharmacological effects of these alkaloids that have significant ties to analgesia.

Journal: Molecules (Basel, Switzerland) (2021)
Publication types: Journal Article;Review
Nitrogen-Rich Porous Organic Polymers with Supported Ag Nanoparticles for Efficient CO2Conversion.

As co2emissions increase and the global climate deteriorates, converting co2into valuable chemicals has become a topic of wide concern.The development of multifunctional catalysts for efficient co2conversion remains a major challenge.Herein, two porous organic polymers (npops) functionalized with covalent triazine and triazole n-heterocycles are synthesized through the copper(i)-catalyzed azide-alkyne cycloaddition (cu aac) reaction.The npops have an abundant microporous content and high specific surface area, which confer them excellent co2affinities with a co2adsorption capacity of 84.0 mg g-1and 63.7 mg g-1, respectively, at 273 k and 0.1 mpa.After wet impregnation and in situ reductions, ag nanoparticles were supported in the npops to obtain ag@npops with high dispersion and small particle size.The ag@npops were applied to high-value conversion reactions of co2with propargylic amines and terminal alkynes under mild reaction conditions.The carboxylative cyclization transformation of propargylic amine into 2-oxazolidinone and the carboxylation transformation of terminal alkynes into phenylpropiolic acid had the highest tof values of 1125.1 and 90.9 h-1, respectively.The ag@npop-1 was recycled and used five times without any significant decrease in catalytic activity, showing excellent catalytic stability and durability.

Journal: Nanomaterials (Basel, Switzerland) (2022)
Publication types: Journal Article
A polymer coating which is sticky yet repulsive to water and slippery yet attractive for oils.

A one-step process has been developed to produce a polymer coating which is hydrophobic and oleophilic, but which oil slides off and water adheres to at all tilt angles - including when vertically inclined or inverted.The polymer is transparent, and the plasma coating process is independent of substrate composition and geometry.

Journal: Chemical communications (Cambridge, England) (2020)
Publication types: Journal Article
Babesiosis and Theileriosis in North America.

Babesiaand theileriaare apicomplexan parasites that cause established and emerging diseases in humans, domestic and wild animals.These protozoans are transmitted by ixodid ticks causing babesiosis or theileriosis, both characterized by fever, hemolytic anemia, jaundice, and splenomegaly.In north america (na), the most common species affecting humans is b.Microti, which is distributed in the northeastern and upper midwestern united states (us), where the tick vector ixodes scapularisis established.In livestock,b.Bovisand b.Bigeminaare the most important pathogens causing bovine babesiosis in tropical regions of mexico.Despite efforts toward eradication of their tick vector,rhipicephalus microplus,b.Bovisand b.Bigeminapresent a constant threat of being reintroduced into the southern us and represent a continuous concern for the us cattle industry.Occasional outbreaks of t.Equi, and t.Orientalishave occurred in horses and cattle, respectively, in the us, with significant economic implications for livestock including quarantine, production loss, and euthanasia of infected animals.In addition, a new species,t.Haneyi, has been recently discovered in horses from the mexico-us border.Domestic dogs are hosts to at least four species of babesiain na that may result in clinical disease that ranges from subclinical to acute, severe anemia.Herein we review the pathogenesis, diagnosis, and epidemiology of the most important diseases caused by babesiaand theileriato humans, domestic and wild animals in canada, the us, and mexico.

Journal: Pathogens (Basel, Switzerland) (2022)
Publication types: Journal Article;Review
Understanding innovation of health technology assessment methods: the IHTAM framework.

Adequate methods are urgently needed to guarantee the good practice of health technology assessment (hta) for technologies with novel properties.The aim of the study was to construct a conceptual framework to help understand the innovation of hta methods (ihtam).The construction of the ihtam framework was based on two scoping reviews, one on the current practice of innovating methods, that is existing hta frameworks, and one on theoretical foundations for innovating methods outside the hta discipline.Both aimed to identify and synthesize concepts of innovation (i.e., innovation processes and roles of stakeholders in innovation).Using these concepts, the framework was developed in iterative brainstorming sessions and subsequent discussions with representatives from various stakeholder groups.The framework was constructed based on twenty documents on innovating hta frameworks and fourteen guidelines from three scientific disciplines.It includes a generic innovation process consisting of three phases ("identification," "development," and "implementation") and nine subphases.In the framework, three roles that hta stakeholders can play in innovation ("developers," "practitioners," and "beneficiaries") are defined, and a process on how the stakeholders innovate hta methods is included.The ihtam framework visualizes systematically which elements and stakeholders are important to the development and implementation of novel hta methods.The framework could be used by all stakeholders involved in hta innovation to learn how to engage dynamically and collaborate effectively throughout the innovation process.Hta stakeholders in practice have welcomed the framework, though additional testing of its applicability and acceptance is essential.

Journal: International journal of technology assessment in health care (2022)
Publication types: Journal Article
Mechanical Properties of a Calcium Dietary Supplement, Calcium Fumarate Trihydrate.

The mechanical properties of calcium fumarate trihydrate, a 1d coordination polymer considered for use as a calcium source for food and beverage enrichment, have been determined via nanoindentation and high-pressure x-ray diffraction with single crystals.The nanoindentation studies reveal that the elastic modulus (16.7-33.4 gpa, depending on crystallographic orientation), hardness (1.05-1.36 gpa), yield stress (0.70-0.90 gpa), and creep behavior (0.8-5.8 nm/s) can be rationalized in view of the anisotropic crystal structure; factors include the directionality of the inorganic ca-o-ca chain and hydrogen bonding, as well as the orientation of the fumarate ligands.High-pressure single-crystal x-ray diffraction studies show a bulk modulus of ∼ 20 gpa, which is indicative of elastic recovery intermediate between small molecule drug crystals and inorganic pharmaceutical ingredients.The combined use of nanoindentation and high-pressure x-ray diffraction techniques provides a complementary experimental approach for probing the critical mechanical properties related to tableting of these dietary supplements.

Journal: Inorganic chemistry (2015)
Publication types: Journal Article;Research Support, Non-U.S. Gov't