syedzayyan/paper_mill_benchmark huggingface dataset:
Rosiglitazone Ameliorates Cardiac and Skeletal Muscle Dysfunction by Correction of Energetics in Huntington's Disease.

Huntington's disease (hd) is a rare neurodegenerative disease that is accompanied by skeletal muscle atrophy and cardiomyopathy.Tissues affected by hd (central nervous system [cns], skeletal muscle, and heart) are known to suffer from deteriorated cellular energy metabolism that manifests already at presymptomatic stages.This work aimed to test the effects of peroxisome proliferator-activated receptor (ppar)-γ agonist-rosiglitazone on grip strength and heart function in an experimental hd model-on r6/1 mice and to address the mechanisms.We noted that rosiglitazone treatment lead to improvement of r6/1 mice grip strength and cardiac mechanical function.It was accompanied by an enhancement of the total adenine nucleotides pool, increased glucose oxidation, changes in mitochondrial number (indicated as increased citric synthase activity), and reduction in mitochondrial complex i activity.These metabolic changes were supported by increased total antioxidant status in hd mice injected with rosiglitazone.Correction of energy deficits with rosiglitazone was further indicated by decreased accumulation of nucleotide catabolites in hd mice serum.Thus, rosiglitazone treatment may not only delay neurodegeneration but also may ameliorate cardio- and myopathy linked to hd by improvement of cellular energetics.

Journal: Cells (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Quantitative serum determination of CD3, CD4, CD8, CD16, and CD56 in women with primary infertility: The role of cell-mediated immunity.

Cellular adaptive immunity plays an essential role in the etiology of primary infertility.This study aimed to measure the t-lymphocyte subpopulations and natural killer (nk) cells in infertile women compared with healthy ones.Materials and methods from january to september 2021, we conducted this cross-sectional study among women with primary infertility, and healthy women were referred to isfahan fertility and infertility center affiliated with najafabad university of medical sciences in isfahan, iran for immunological investigations.For each person, we determined quantitative serum measurements of cd3, cd4, cd8, cd4/cd8, cd16, cd56, and cd56+16.Results this study included one hundred and fifty-one infertile women with a mean age of 31.4±4.7 years and 46 healthy women with a mean age of 31.5±3.4 years.Compared to the controls, immunophenotyping findings in infertile patients revealed a significant drop in cd8 t cells [p=0.01, 95% confidence interval (ci) 0.53 to 4.57] and the percentage of cd 56 nk cells (p=0.005, 95% ci 0.74 to 4.03) in infertile patients.Conclusion despite having a normal quantity of cd3 t cells, infertile women had lower cd8 t cells and cd56 nk cells than the controls.More studies are needed to confirm the role of cell-mediated assessments as a screening test in patients with primary infertility.

Journal: Turkish journal of obstetrics and gynecology (2022)
Publication types: Journal Article
Molecular Mechanisms of Kidney Injury and Repair.

Chronic kidney disease (ckd) will become the fifth global cause of death by 2040, thus emphasizing the need to better understand the molecular mechanisms of damage and regeneration in the kidney.Ckd predisposes to acute kidney injury (aki) which, in turn, promotes ckd progression.This implies that ckd or the aki-to-ckd transition are associated with dysfunctional kidney repair mechanisms.Current therapeutic options slow ckd progression but fail to treat or accelerate recovery from aki and are unable to promote kidney regeneration.Unraveling the cellular and molecular mechanisms involved in kidney injury and repair, including the failure of this process, may provide novel biomarkers and therapeutic tools.We now review the contribution of different molecular and cellular events to the aki-to-ckd transition, focusing on the role of macrophages in kidney injury, the different forms of regulated cell death and necroinflammation, cellular senescence and the senescence-associated secretory phenotype (saps), polyploidization, and podocyte injury and activation of parietal epithelial cells.Next, we discuss key contributors to repair of kidney injury and opportunities for their therapeutic manipulation, with a focus on resident renal progenitor cells, stem cells and their reparative secretome, certain macrophage subphenotypes within the m2 phenotype and senescent cell clearance.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article;Review
Correlation between the Metal and Organic Components, Structure Property, and Gas-Adsorption Capacity of Metal-Organic Frameworks.

Metal-organic frameworks (mofs) are materials in which metals and organic compounds form crystalline and porous structures.Previous studies have investigated the relationships between the structure properties and physical properties of mofs through molecular simulations, but the overall relationships in mofs, including the relationships between the metals and organic components and the experimentally measured physical properties, have not been clarified.In this study, we developed two regression models between three elements in mofs: the components, structure properties, and gas-adsorption capacities as physical properties.Using a nonlinear regression analysis method, we succeeded in predicting the structure properties from the components and the physical properties from the structure properties.

Journal: Journal of chemical information and modeling (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Transformation of Levulinic Acid to Valeric Biofuels: A Review on Heterogeneous Bifunctional Catalytic Systems.

Valerate esters (vaes) commonly derived from levulinic acid (la), which is deemed as one of the most promising biomass platform molecules, have been hailed as "valeric biofuels" in recent years.The cascade transformation of la to vaes consists of a series of acid- and metal-catalyzed processes alternately, in which heterogeneous bifunctional catalysts are required for better catalytic performance.The transformation pathway from la to vaes is presented, and bifunctional catalytic systems for the cascade transformation of la into valeric acid (va) and its esters, as well as one-pot conversion processes, are reviewed.Additionally, effects of metal and acid sites on the catalytic performance are discussed in detail.Impacts of and improvements to coke deposition, which is determined to be the primary reason for the reduction in catalytic activity, are also analyzed.Finally, feasible suggestions are proposed for enhanced catalytic performance and a reduction in overall costs.

Journal: ChemSusChem (2019)
Publication types: Journal Article;Review
Incidental Adrenal Masses: Adherence to Guidelines and Methods to Improve Initial Follow-Up: A Systematic Review.

Incidental adrenal masses (iams) are detected in approximately 1%-2% of abdominal computed tomography (ct) scans.Recent estimates suggest that more than 70-million relevant ct scans are performed annually in the united states; thus, iams represent a significant clinical entity.Most clinical guidelines recommend an initial follow-up evaluation that includes imaging and biochemical testing after index iam detection.Methods systematic review of literature in the pub med, embase and web of science databases to determine whether guidelines regarding iam evaluation are followed and to identify effective management strategies.Our initial search was in january 2018 and updated in november, 2019.Results 31 studies met inclusion criteria.In most institutions, only a minority of patients with iams undergo initial follow-up imaging (median 34%, iqr 20%-50%) or biochemical testing (median 18%, iqr 15%-28%).2 interventions shown to improve iam evaluation are iam-specific recommendations in radiology reports and dedicated multi-disciplinary teams.Interventions focused solely on alerting the ordering clinician or primary care provider to the presence of an iam have not demonstrated effectiveness.Patients who are referred to an endocrinologist are more likely to have a complete iam evaluation, but few are referred.Discussion most patients with an iam do not have an initial evaluation.The radiology report has been identified as a key component in determining whether iams are evaluated appropriately.Care teams dedicated to management of incidental radiographic findings also improve iam follow-up.Although the evidence base is sparse, these interventions may be a starting point for further inquiry into optimizing care in this common clinical scenario.

Journal: The Journal of surgical research (2022)
Publication types: Journal Article;Systematic Review
SARS-CoV-2 antibody seroprevalence follow-up in Malagasy blood donors during the 2020 COVID-19 Epidemic.

The incidence of the 2020 covid-19 epidemic in africa seems to be different from that of the rest of the world, however its true extent is probably underestimated.Conducting population based sero-surveys during the epidemic has moreover been extremely challenging, driving our group and others to study blood donor samples.Methods we collected regional epidemiological covid-19 surveillance data, and simultaneously monitored anti-sars-co v-2 antibody seroprevalences monthly throughout the epidemic in 5 major region-associated blood transfusion centres of madagascar over a period of 9 months.Findings soon after attaining the first epidemic peaks between may and august 2020, both crude and population-weighted test-performance-adjusted seroprevalences of anti-sars-co v-2 antibodies was in malagasy blood donors rapidly increased up to over 40% positivity.Interpretation these findings suggest a high cumulative incidence of infection and seroconversion, which may have contributed to the observed deceleration of infection rates, but was not sufficient to prevent the second epidemic wave that struck madagascar in spring 2021.Funding this project was funded by the united states agency for international development.

Journal: EBioMedicine (2021)
Publication types: Journal Article;Multicenter Study
Enhanced on-chip phase measurement by inverse weak value amplification.

Optical interferometry plays an essential role in precision metrology such as in gravitational wave detection, gyroscopes, and environmental sensing.Weak value amplification enables reaching the shot-noise-limit of sensitivity, which is difficult for most optical sensors, by amplifying the interferometric signal without amplifying certain technical noises.We implement a generalized form of weak value amplification on an integrated photonic platform with a multi-mode interferometer.Our results pave the way for a more sensitive, robust, and compact platform for measuring phase, which can be adapted to fields such as coherent communications and the quantum domain.In this work, we show a 7 d b signal enhancement in our weak value device over a standard mach-zehnder interferometer with equal detected optical power, as well as frequency measurements with 2 k hz sensitivity by adding a ring resonator.

Journal: Nature communications (2021)
Publication types: Journal Article
Symposium Introduction: A Decade of the Tobacco Control Act: Progress, Setbacks, and the Future of Tobacco Control.

The landmark symposium, a decade of the tobacco control act: progress, setbacks, and the future of tobacco control, organized by the public health law center and held in conjunction with the 2019 national conference on tobacco or health, assessed the first 10 years of federal tobacco regulation.In this introduction to the symposium, the public health law center's executive director provides the context for insights by prominent experts from government, health organizations, and academia, acknowledging the mixed record of u.s.Food and drug administration (fda) regulation to date and suggesting that the agency's ultimate success or failure will be determined by the answers to three fundamental, but still unresolved, questions: what is the true goal of federal regulation?How boldly or cautiously will the fda approach that goal?And who will the agency serve?The answers to those questions, he argues, will determine the prospects for progress in controlling the nation's leading cause of preventable death.

Journal: The Journal of legal medicine (2020)
Publication types: Introductory Journal Article
Prostate Organoid Cultures as Tools to Translate Genotypes and Mutational Profiles to Pharmacological Responses.

Presented here is a protocol to study pharmacodynamics, stem cell potential, and cancer differentiation in prostate epithelial organoids.Prostate organoids are androgen responsive, three-dimensional (3d) cultures grown in a defined medium that resembles the prostatic epithelium.Prostate organoids can be established from wild-type and genetically engineered mouse models, benign human tissue, and advanced prostate cancer.Importantly, patient derived organoids closely resemble tumors in genetics and in vivo tumor biology.Moreover, organoids can be genetically manipulated using crispr/cas9 and sh rna systems.These controlled genetics make the organoid culture attractive as a platform for rapidly testing the effects of genotypes and mutational profiles on pharmacological responses.However, experimental protocols must be specifically adapted to the 3d nature of organoid cultures to obtain reproducible results.Described here are detailed protocols for performing seeding assays to determine organoid formation capacity.Subsequently, this report shows how to perform drug treatments and analyze pharmacological response via viability measurements, protein isolation, and rna isolation.Finally, the protocol describes how to prepare organoids for xenografting and subsequent in vivo growth assays using subcutaneous grafting.These protocols yield highly reproducible data and are widely applicable to 3d culture systems.

Journal: Journal of visualized experiments : JoVE (2019)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Video-Audio Media
Trajectories of Depressive Symptoms, Neurocognitive Function, and Viral Suppression With Antiretroviral Therapy Among Youth With HIV Over 36 months.

Depression and neurocognitive impairment are highly prevalent among persons living with hiv and associated with poorer clinical outcomes; however, longitudinal studies of depression-neurocognition relationships in youth living with hiv (ylwh), and the role of antiretroviral therapy (art), are lacking.This study tested whether (1) depressive symptomatology, across somatic, cognitive, and affective symptom domains, improved with art and (2) more severe depressive symptoms at baseline were associated with poorer neurocognitive function and poorer hiv suppression.Setting data were collected from 181 ylwh (18-24 years) who were treatment-naive, a subset of whom (n = 116) initiated art.Methods participants were categorized into elevated (ds) or nonelevated (non-ds) depressive symptom groups at entry (beck depression inventory-ii ≥14) and followed for 36 months.Neurocognition (5-domain battery) and depressive symptoms were repeatedly assessed.Longitudinal models examined depressive symptomatology, neurocognition, and odds of hiv nonsuppression by group.Results greater improvements in depressive symptoms were observed in the ds group over 36 months [beta = -0.14, (-0.24 to -0.03)], particularly within cognitive and affective domains.Verbal learning performance increased in the ds group [beta = 0.13, (0.01 to 0.24)], whereas psychomotor function improved somewhat in the non-ds group [beta = -0.10, (-0.22 to 0.00)].Adjusted for art adherence, odds of hiv nonsuppression did not significantly differ by group [odds ratio = 0.22, (0.04 to 1.23)]; however, greater somatic symptoms at study entry were associated with an increased risk of nonsuppression over time [odds ratio = 2.33 (1.07 to 5.68)].Conclusion depressive symptoms were associated with differential neurocognitive trajectories, and somatic depressive symptoms at baseline may predict poorer subsequent hiv suppression.Identifying and treating depressive symptoms at art initiation may benefit neurocognitive and clinical outcomes in ylwh.

Journal: Journal of acquired immune deficiency syndromes (1999) (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural
A Case of Peripheral Precocious Puberty May Be Caused by a Diet Containing Phytosterols in a 20-Month-Old Boy.

Introduction precocious puberty in boys generally remains an etiology.In addition to the causes of endogenous hormone changes, endocrine-disrupting chemicals of exogenous substances may interfere with children's pubertal development.Case presentation a 20-month-old boy presented with peripheral precocious puberty may be due to a phytosterol-containing diet.The patient came to see a doctor because of acne, hairiness, increased penis size, and coarse voice.Genital examination revealed a tanner stage of 2 for pubic hair and a stretched penile length of 5 cm, which disagreed with the prepubertal testicular volume (2 m l bilaterally).At the same time, he was found to have pigmentation on both nipples and areola.The concentrations of estradiol and testosterone increased significantly.Since the age of 6 months, the patient had taken food added with a large amount of chicken essence seasoning (a flavoring in chinese cooking), with an average of 15 g of this seasoning a day.A kind of phytosterol (c29h48o) was detected in chicken essence seasoning by high-performance liquid chromatography-tandem mass spectrometry (hplc-ms).After avoidance of the chicken essence seasoning, the patient's sex hormone levels decreased, all clinical symptoms returned to normal, and no further development of secondary sexual characteristics was detected.Conclusion this phytosterol-containing diet may be responsible for the sexual development of this patient.However, the mechanism of how phytosterols affect the process of development in children needs to be further explored.

Journal: Hormone research in paediatrics (2022)
Publication types: Case Reports;Journal Article
Specialized androgen synthesis in skeletal muscles that actuate elaborate social displays.

Androgens mediate the expression of many reproductive behaviors, including the elaborate displays used to navigate courtship and territorial interactions.In some vertebrates, males can produce androgen-dependent sexual behavior even when levels of testosterone are low in the bloodstream.One idea is that select tissues make their own androgens from scratch to support behavioral performance.We first studied this phenomenon in the skeletal muscles that actuate elaborate sociosexual displays in downy woodpeckers and two songbirds.We show that the woodpecker display muscle maintains elevated testosterone when the testes are regressed in the non-breeding season.Both the display muscles of woodpeckers, as well as the display muscles in the avian vocal organ (syrinx) of songbirds, express all transporters and enzymes necessary to convert cholesterol into bioactive androgens locally.In a final analysis, we broadened our study by looking for these same transporters and enzymes in mammalian muscles that operate at different speeds.Using rna-seq data, we found that the capacity for de novo synthesis is only present in 'superfast' extraocular muscle.Together, our results suggest that skeletal muscle specialized to generate extraordinary twitch times and/or extremely rapid contractile speeds may depend on androgenic hormones produced locally within the muscle itself.Our study therefore uncovers an important dimension of androgenic regulation of behavior.

Journal: The Journal of experimental biology (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.;Research Support, Non-U.S. Gov't
Experimental Study on Single Corner Cold Bending Mechanical Response of Laminated of PVB Interlayer Tempered Glass Panes and the Coupling Effect with Load.

The cold bending method is a type of curved glass curtain wall construction method that has been used in practical engineering for a short time.It has the advantages of simple operation, high efficiency and low cost.However, the mechanical response and properties of glass panes caused by cold bending have not been solved effectively.To study the mechanical response and the properties of cold formed laminated tempered glass panes after applying with a wind load, cold bending and load tests of 9 laminated tempered glass panes were conducted by the orthogonal experimental design method.The effects of cold bending curvature, glass pane thickness and interlayer thickness were considered.In this paper, the response law of cold bending stress to the curvature and the relationship among the influencing factors were analyzed.The variation process of stress, the deflection of cold-formed glass panes under uniform load and the characteristics affected by cold-formed stress and deformation were studied.The results show that the cold bending stress is distributed in a saddle shape, and the curvature has the greatest influence on the cold bending stress, followed by the thickness of the glass panes.The influence of the interlayer thickness is small.The maximum stress appears near the corner of the short side direction adjacent to the cold bending corner.The cold bending stress increases linearly with increasing cold bending curvature.The cold bending stress and deformation have little effect on the change process of the later stage load effect.

Journal: Materials (Basel, Switzerland) (2021)
Publication types: Journal Article
Targeted photodynamic-induced singlet oxygen production by peptide-conjugated biodegradable nanoparticles for treatment of skin melanoma.

Photodynamic therapy (pdt) has been determined to be a promising treatment modality in the most resistant tumors such as malignant melanoma.However, the key cytotoxic agent of pdt, -singlet oxygen (1o2) - represents a high risk of photodynamic-associated side effects e.g.Skin photosensitization.Recently, controllable photosensitization, where1o2is produced on demand, has received increasing attention.In our study, this could be achieved via loading the photosensitizer (ps) in nanoparticles (nps) decorated with target-specific moieties characterized by1o2quenching abilities to specifically locate the ps in the targeted cells and assure that1o2is only produced where desired after cellular processing.Methods polymeric and hybrid lipid-polymer nps were formulated and assayed for their physicochemical properties.This was followed by conjugation with an active targeting ligand, c rgdyk, cyclic (arginine-glycine-aspartic acid-d-tyrosine-lysine) peptide.Finally, photodynamic potential of the selected formulations was assayed by quantification of1o2production and in vitro cytotoxicity.Results three formulations were selected and nominated to be formulations of choice (focs); foc-1 (200 nm, polymeric), foc-2 (130 nm, polymeric) and foc-3 (200 nm, hybrid).Physicochemical properties, most importantly particle size and nps' composition have shown to be the major determinants in targeted nps'1o2production and pdt-mediated cytotoxicity of melanoma.Conclusion proper selection of formulations intended for pdt application and target-specific ligands could achieve dual targeting; enhanced accumulation of nps and protection of1o2production elsewhere other than target cells.

Journal: Photodiagnosis and photodynamic therapy (2018)
Publication types: Journal Article