syedzayyan/paper_mill_benchmark huggingface dataset:
Effect of Early Rehabilitation Nursing on Motor Function and Living Ability of Patients with Traumatic Brain Injury Based on Orem's Self-Care Theory.

To explore the effect of early rehabilitation nursing on motor function and living ability of patients with traumatic brain injury (tbi) based on orem's self-care theory.Methods a total of 60 patients with tbi treated in our hospital from february 2019 to june 2021 were enrolled.The patients were randomly divided into a control group and a research group.The control group adopted the early rehabilitation nursing model, while the research group adopted the early rehabilitation nursing model based on orem's self-nursing theory.Nursing satisfaction, fugl-meyer score, nih-ss score, barthel index, quality of life score, and compliance were in the comparison of the two groups.Results the nursing satisfaction of the research group was higher than that of the control group (p< 0.05).Compared with the control group, the fugl-meyer scores of the research group were higher at 1 month, 2 months, and 3 months after nursing (p< 0.05).After nursing, the nih-ss score of the two groups decreased.In the comparison of the two groups, the nih-ss score of the research group at 1 month, 2 months, and 3 months after nursing was lower (p< 0.05).After nursing, the barthel index of the two groups increased.In the comparison of the two groups, the barthel index of the research group was higher compared to the control group at 1 month, 2 months, and 3 months after nursing (p< 0.05).The scores of physiological function, psychological function, social function, and health self-cognition in the research group were lower (p< 0.05).The compliance rate of the research group was higher than that of the control group (p< 0.05).Conclusion patients with tbi receive early rehabilitation nursing based on orem's self-care theory, which can effectively improve patient satisfaction and compliance and achieve the purpose of improving motor function and living ability.This nursing program is worth popularizing in the clinic.

Journal: Computational intelligence and neuroscience (2022)
Publication types: Journal Article;Randomized Controlled Trial
Role of Tmem163 in zinc-regulated insulin storage of MIN6 cells: Functional exploration of an Indian type 2 diabetes GWAS associated gene.

Genome wide association study for type 2 diabetes discovered tmem163 as a risk locus.Perturbations in tmem163 expression was reported to be associated with impaired intracellular zinc homeostasis.Physiological concentration of zinc is instrumental to maintain insulin storage and functionality in pancreatic β cells.We found abundant tmem163 expression in human pancreas, both at transcriptional and translational levels.Knockdown of endogenous tmem163 in min6 cells resulted in increased intracellular zinc and total insulin content, coupled with compromised insulin secretion at high glucose stimuli.Furthermore, tmem163 knockdown led to enhanced cellular glucose uptake.Upon next generation sequencing, one-third of the studied t2d patients were found to have a novel missense variant in tmem163 gene.Study participants harboring this missense variant displayed a trend of higher glycemic indices.This is the first report on exploring the biological role of tmem163 in relation to t2d pathophysiology.

Journal: Biochemical and biophysical research communications (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Can We Incorporate Societal Values in Resource Allocation Decisions Among Disease Categories? An Empirical Approach.

S historically, resource allocation decisions in healthcare are based on univariate approaches, inevitably overlooking value dimensions that are essential from a societal welfare maximization perspective.This article aims to present a wider perspective on decision making that incorporates societal values when prioritizing future resource allocation among disease areas.Methods sociotechnical application of multiple-criteria decision analysis with a set of criteria (value judgments) that are based on positive as well as normative dimensions of resource allocation.We use greece as a case study.Societal value judgments were sourced via a multidisciplinary panel of experts who collectively provided criteria weights and scores for each alternative (16 disease categories, classified according to the global burden of disease study) against each criterion.An additive value function provided the total value in priority preference for each alternative.Results the criteria that were deemed relevant to the decision-making process and their respective relative weights were burden of disease (0.245), capacity to benefit (0.190), direct cost and projected changes in the next 5 years (0.160), indirect cost (0.132), intensity of unmet needs (0.109), incidence of catastrophic expenditure (0.091), and caring externalities (0.073).The additive value function revealed that the top 5 priorities in highest total value scores were neoplasms, circulatory diseases, injuries, neurologic diseases, and musculoskeletal diseases.Conclusions incorporation of societal value criteria in resource allocation decisions can highlight priorities and lead to different sets of planning decisions than solely demand-driven allocation.

Journal: Value in health regional issues (2021)
Publication types: Journal Article
Semivolatile organic compounds in French schools: Partitioning between the gas phase, airborne particles and settled dust.

The indoor environmental quality in classrooms can largely affect children's daily exposure to indoor chemicals in schools.To date, there has not been a comprehensive study of the concentrations of semivolatile organic compounds (svocs) in french schools.Therefore, the french observatory for indoor air quality (oqai) performed a field study of svocs in 308 nurseries and elementary schools between june 2013 and june 2017.The concentrations of 52 svocs, including phthalates, polybrominated diphenyl ethers (pbdes), polychlorinated biphenyls (pcbs), polycyclic aromatic hydrocarbons (pahs), synthetic musks, and pesticides, were measured in air and settled dust (40 svocs in both air and dust, 12 in either air or dust).The results showed that phthalates had the highest concentrations among the svocs in both the air and dust.Other svocs, including tributyl phosphate, fluorene, phenanthrene, gamma-hexachlorocyclohexane (gamma-hch, lindane), galaxolide, and tonalide, also showed high concentrations in both the air and dust.Theoretical equations were developed to estimate the svoc partitioning between the air and settled dust from either the octanol/air partition coefficient or the boiling point of the svocs.The regression constants of the equations were determined using the data set of the present study for phthalates and pahs.

Journal: Indoor air (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Green-synthesized nanocatalysts and nanomaterials for water treatment: Current challenges and future perspectives.

Numerous hazardous environmental pollutants in water bodies, both organic and inorganic, have become a critical global issue.As greener and bio-synthesized versions of nanoparticles exhibit significant promise for wastewater treatment, this review discusses trends and future prospects exploiting the sustainable applications of green-synthesized nanocatalysts and nanomaterials for the removal of contaminants and metal ions from aqueous solutions.Recent trends and challenges about these nanocatalysts and nanomaterials and their potential applications in wastewater treatment and water purification are highlighted including toxicity and biosafety issues.This review delineates the pros and cons and critical issues pertaining to the deployment of these nanomaterials endowed with their superior surface area, mechanical properties, significant chemical reactivity, and cost-effectiveness with low energy consumption, for removal of hazardous materials and contaminants from water; comprehensive coverage of these materials for industrial wastewater remediation, and their recovery is underscored by recent advancements in nanofabrication, encompassing intelligent and smart nanomaterials.

Journal: Journal of hazardous materials (2021)
Publication types: Journal Article;Review
The effect of doping and strain on superconductivity of T-graphene.

As an allotrope of graphene, t-graphene was predicted to be an intrinsic two-dimensional (2d) superconductor with a superconducting critical temperature (tc) of about 20.8 k [guet al., chin.Phys.Lett.36, 097401 (2019)].In this work, based on first-principles calculations, hole doping and biaxial tensile strain (bts) are considered to modulate the electron-phonon coupling (epc) and superconductivity of t-graphene.It is found that the epc constant of t-graphene is 0.807 and the calculated critical temperature tcis 28.2 k at a doping level of 0.5 hole per unit cell (3.31 × 1014cm-2) and 12% bts.Furthermore, when 0.8 hole per unit cell (5.43 × 1014cm-2) doping and 10% bts are applied, the epc constant is 0.939, and the tccan be boosted to 35.2 k, which is higher than those of the pristine t-graphene and many other 2d carbon-based superconductors.

Journal: Physical chemistry chemical physics : PCCP (2022)
Publication types: Journal Article
Impact of cardiorespiratory rehabilitation program on submaximal exercise capacity of Tunisian male patients with post-COVID19: A pilot study.

Post-covid19 patients suffer from persistent respiratory, cardiovascular, neurological, and musculoskeletal health complaints such as dyspnea, chest pain/discomfort, and fatigue.In tunisia, the potential benefits of a cardiorespiratory rehabilitation program (crrp) after covid19 remain unclear.The main aim of this study was to evaluate the impact of a crrp on submaximal exercise capacity, evaluated through the 6-min walk test (6mwt) data in post-covid19 tunisian patients.This was a cross-sectional study including 14 moderate to severe covid19 patients aged from 50 to 70 years.Crrp was performed after the end of patients' hospitalization in covid19 units for extensive or severe extents of covid19.Dyspnea (modified medical research council), spirometry data, handgrip strength values, 6mwt data, and 6-min walk work (i.e., 6-min walk distance x weight) were evaluated 1-week pre-crrp, and 1-week post-crrp.Crrp included 12 sessions [3 sessions (70 min each)/week for 4 weeks].Exercise-training included aerobic cycle endurance, strength training, and educational sessions.Comparing pre- and post- crrp results showed significant improvements in the means±standard deviations of dyspnea by 1.79 ± 0.80 points (p< 0.001), forced expiratory volume in one second by 110 ± 180 ml (p= 0.04), 6-min walk distance by 35 ± 42 m (p= 0.01), 6-min walk work by 2,448 ± 3,925 mkg (p= 0.048), resting heart-rate by 7 ± 9 bpm (p= 0.02) and resting diastolic blood pressure by 6 ± 10 mm hg (p= 0.045).In tunisia, crrp seems to improve the submaximal exercise capacity of post-covid19 patients, mainly the 6-min walk distance and work.

Journal: Frontiers in physiology (2022)
Publication types: Journal Article
Rotavirus NSP1 Contributes to Intestinal Viral Replication, Pathogenesis, and Transmission.

Rotavirus (rv)-encoded nonstructural protein 1 (nsp1), the product of gene segment 5, effectively antagonizes host interferon (ifn) signaling via multiple mechanisms.Recent studies with the newly established rv reverse genetics system indicate that nsp1 is not essential for the replication of the simian rv sa11 strain in cell culture.However, the role of nsp1 in rv infectionin vivoremains poorly characterized due to the limited replication of heterologous simian rvs in the suckling mouse model.Here, we used an optimized reverse genetics system and successfully recovered recombinant murine rvs with or without nsp1 expression.While the nsp1-null virus replicated comparably with the parental murine rv in ifn-deficient and ifn-competent cell linesin vitro, it was highly attenuated in 5-day-old wild-type suckling pups in both the 129sv and c57bl/6 backgrounds.In the absence of nsp1 expression, murine rv had significantly reduced replication in the ileum, systemic spread to mesenteric lymph nodes, fecal shedding, diarrhea occurrence, and transmission to uninoculated littermates.The defective replication of the nsp1-null rv in small intestinal tissues occurred as early as 1 day postinfection.Of interest, the replication and pathogenesis defects of nsp1-null rv were only minimally rescued in stat1knockout pups, suggesting that nsp1 facilitates rv replication in an ifn-independent manner.Our findings highlight a pivotal function of nsp1 during homologous rv infectionsin vivoand identify nsp1 as an ideal viral protein for targeted attenuation for future vaccine development.importancerotavirus remains one of the most important causes of severe diarrhea and dehydration in young children worldwide.Although nsp1 is dispensable for rotavirus replication in cell culture, its exact role in virus infectionin vivoremains unclear.In this study, we demonstrate, for the first time in a pathologically valid homologous small animal model, that in the context of a fully replication-competent, pathogenic, and transmissible murine rotavirus, loss of nsp1 expression substantially attenuated virus replication in the gastrointestinal tract, diarrheal disease, and virus transmission.Notably, the nsp1-deficient murine rotavirus also replicated poorly in mice lacking host interferon or inflammasome signaling.Our data provide the first piece of evidence that nsp1 is essential for murine rotavirus replicationin vivo, making it an attractive target for developing improved next-generation rotavirus vaccines better suited for socioeconomically disadvantaged and immunocompromised individuals.

Journal: mBio (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Amplification-Free Detection of SARS-CoV-2 and Respiratory Syncytial Virus Using CRISPR Cas13a and Graphene Field-Effect Transistors.

The clustered regularly interspaced short palindromic repeats (crispr)/crispr-associated (cas) systems have recently received notable attention for their applications in nucleic acid detection.Despite many attempts, the majority of current crispr-based biosensors in infectious respiratory disease diagnostic applications still require target preamplifications.This study reports a new biosensor for amplification-free nucleic acid detection via harnessing the trans-cleavage mechanism of cas13a and ultrasensitive graphene field-effect transistors (g fets).Crispr cas13a-g fet achieves the detection of sars-co v-2 and respiratory syncytial virus (rsv) genome down to 1 attomolar without target preamplifications.Additionally, we validate the detection performance using clinical sars-co v-2 samples, including those with low viral loads (ct value >30).Overall, these findings establish our crispr cas13a-g fet among the most sensitive amplification-free nucleic acid diagnostic platforms to date.

Journal: Angewandte Chemie (International ed. in English) (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
Mechanism of Multi-Stage Degradation in Hot Bitumen of Micronized Powder Elastomeric Modifiers from Worn-Out Tire's Rubber.

For the first time, by atomic force microscopy (afm) methods, micro- and nanofragments of micronized powder elastomeric modifier (pem) formed at the short-term (3 min at 160 °c) interaction of pem with hot bitumen have been demonstrated.It is the technology of high-temperature shear-induced grinding of a worn-out tire's crumb rubber or its co-grinding with styrene-butadiene-styrene (sbs) block copolymer which provides the creation of the pem structure inclined to rapid degradation in hot bitumen.The formation just after the preparation process of a new structure of a modified binder, more resistant to external effects, is supported by the data of rheological tests.Performance tests for a modified binder using superpave standard adopted by the road industry for bituminous binders showed an extended temperature range, resistance to rutting, and low-temperature and fatigue cracking.The better resistance to low-temperature and fatigue cracking is certainly related to energy absorption and crack growth stopping in the presence of micron and submicron resilient pem fragments in accordance with the mechanism of increasing impact toughness in plastics.

Journal: Polymers (2022)
Publication types: Journal Article
Lived Experience of Breast Cancer Survivors: A Phenomenological Study.

Breast cancer (br ca) is the most common cancer worldwide.Five-year survival rates among individuals with br ca are the highest of all types of cancer, yet there is a paucity of knowledge about the experiences of survivors regarding living through their diagnosis and treatment.In-depth interviews and the systematic analysis of self-reported experiences may provide in-depth information about the br ca survivorship experience.Purpose this qualitative study was designed to identify and elucidate the lived experiences of thai women with br ca who successfully completed their treatment program for br ca and/or treatment with chemotherapy for over 5 years and are currently cancer-free.Methods a phenomenological method was employed.Survivors of br ca who met the inclusion criteria were purposively selected and invited to take part in the study.Study data were collected between january and march 2019.An open-ended, in-depth interview guide was used to direct the conversation concerning the participants' experiences and perceptions.Thematic analysis was used for data analysis.Results data saturation was reached after 12 interviews.The five themes derived from the data include (a) being distressed, (b) accepting treatments and seeking alternative treatments, (c) going through difficult times, (d) becoming a stronger person, and (e) becoming thankful.Conclusions/implications for practice the experiences and themes identified enhance scholarly understanding regarding the experience of survivors of br ca.A true understanding of this experience enables healthcare providers to craft and deliver appropriate interventions that provide quality care and improve women's health, thereby enhancing their quality of life.The results of this study may contribute to the development of new theories by using different qualitative approaches such as grounded theory.

Journal: The journal of nursing research : JNR (2022)
Publication types: Journal Article
Acromegaly accompanied by diabetes mellitus and polycystic kidney disease.

Acromegaly is characterized by autonomous excessive growth hormone (gh) secretion, generally due to gh-producing pituitary adenoma, and is associated with various systemic comorbidities including diabetes mellitus.Polycystic kidney disease (pkd) is characterized by the growth of numerous cysts in the kidneys that deteriorate renal function.While possible renal effects of excessive gh exposure have been a current issue in experimental medicine, only five cases of coexisting acromegaly and pkd have been reported previously, and little is known regarding the influence of acromegaly on renal disease.We treated a 50-year-old male with diabetes mellitus who showed a sudden and rapid decline of renal function along with increasing proteinuria, which led to diagnoses of pkd and acromegaly.His urinary protein levels were increased together with excessive gh secretion and worsening glycemic control.An increase of total kidney volume was also noted.Transsphenoidal surgery for the pituitary adenoma was successfully performed.Marked improvement of hyperglycemia and proteinuria were observed after the surgery, but renal function was unchanged.The patient's clinical course suggested common aspects of excessive gh secretion as an accelerating factor of the progression of diabetic nephropathy and pkd via direct and indirect pathways.Although coexisting acromegaly and pkd is clinically rare, vigilance for early diagnosis of acromegaly is appropriate in patients with diabetes and/or pkd, especially in those showing unexpected exacerbation of renal dysfunction.

Journal: Endocrine journal (2021)
Publication types: Case Reports;Journal Article
High Performance Generation of H2O2under Piezophototronic Effect with Multi-Layer In2S3Nanosheets Modified by Spherical ZnS and BaTiO3Nanopiezoelectrics.

Manipulating the separation and transportation of photoexcited charge carriers in photoresponsive semiconductors via the piezoelectric polarization effect is an emerging strategy in the field of artificial photosynthesis.However, existing semiconductor photocatalysts, both with a wide range absorption for visible light and superior piezoelectricity are very scarce, leading to a low reactivity of photocatalysis.Here, a multi-layer in2s3nanosheet modified with spherical zn s and ba ti o3nanopiezoelectrics (zn s/in2s3/bto) is reported, generating approximately 378 μm of h2o2in 100 min (and the concentration is still increasing) under co-irradiation of visible light and ultrasound (piezophotocatalysis) in ethanol-water solution; this concentration is higher compared with two phases piezoelectric heterostructures (i.e., zn s/bto, in2s3/bto, and zn s/in2s3) and pure compounds (i.e., zn s, in2s3, and bto), and also higher than that of independent piezo- (≈254 μm) and photocatalysis (≈120 μm).Moreover, the concentration of h2o2generated on zn s/in2s3/bto can be as high as approximately 1160 μm in 5 h of piezophotoreaction after experiencing six cycles of visible light concurrent with ultrasound irradiation.The enhancement of h2o2yield on zn s/in2s3/bto in piezophotocatalysis can be attributed to the piezopotential-induced internal electric polarization field promoting the separation of photoexcited charge carriers, thus boosting the rate of surface photoreaction.

Journal: Small methods (2021)
Publication types: Journal Article
High dispersal capacity of Culicoides obsoletus (Diptera: Ceratopogonidae), vector of bluetongue and Schmallenberg viruses, revealed by landscape genetic analyses.

In the last two decades, recurrent epizootics of bluetongue virus and schmallenberg virus have been reported in the western palearctic region.These viruses affect domestic cattle, sheep, goats and wild ruminants and are transmitted by native hematophagous midges of the genus culicoides (diptera: ceratopogonidae).Culicoides dispersal is known to be stratified, i.e.Due to a combination of dispersal processes occurring actively at short distances and passively or semi-actively at long distances, allowing individuals to jump hundreds of kilometers.Methods here, we aim to identify the environmental factors that promote or limit gene flow of culicoides obsoletus, an abundant and widespread vector species in europe, using an innovative framework integrating spatial, population genetics and statistical approaches.A total of 348 individuals were sampled in 46 sites in france and were genotyped using 13 newly designed microsatellite markers.Results we found low genetic differentiation and a weak population structure for c.Obsoletus across the country.Using three complementary inter-individual genetic distances, we did not detect any significant isolation by distance, but did detect significant anisotropic isolation by distance on a north-south axis.We employed a multiple regression on distance matrices approach to investigate the correlation between genetic and environmental distances.Among all the environmental factors that were tested, only cattle density seems to have an impact on c.Obsoletus gene flow.Conclusions the high dispersal capacity of c.Obsoletus over land found in the present study calls for a re-evaluation of the impact of culicoides on virus dispersal, and highlights the urgent need to better integrate molecular, spatial and statistical information to guide vector-borne disease control.

Journal: Parasites & vectors (2021)
Publication types: Journal Article