syedzayyan/paper_mill_benchmark huggingface dataset:
Chinese English as Foreign Language Teachers' Self-Efficacy and Motivation as Predictors of Burnout.

In contemporary education, educators are a central and focal component of academic structures accountable for education growth.Educators have an effective role in presenting and planning an effective and important academic program.However, they usually experience burnout due to their stressful job that affects the procedure of their teaching.So, considering the variables that help them in mitigating their burnout should be taken into account.The concept such as educator efficacy has recently attracted significant attention in education fields which by itself emphasizes educators and gets them into the focus of attention in education.Also, the concept of motivation has a strong relationship with the expert aspect of the educators and its significance for language educators and their students are increasingly gaining respect in various worldwide settings, in which lower educators' motivation is generally a reason for distress.To focus on the predictability role of these constructs on teachers' burnout, 428 female and male chinese english as foreign language (efl) teachers from more than 17 cities in nine provinces of china were asked to fill out the three scales, namely, teacher motivation, efficacy, and burnout.The main results of the study, achieved through pearson correlation, postulate that the relationships exist among the variables of the study, and by running multiple regression analysis, it is revealed that both variables, namely, self-efficacy and motivation, were the predictors of teachers' burnout, while self-efficacy was a better predictor.Regarding the applications, educator training plans can focus more on educator self-efficacy and motivation, because of their proven important role in decreasing educator burnout.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article
Validation of a New Screening Tool for Dementia: The Simple Observation Checklist for Activities of Daily Living.

And purpose screening tests for dementia such as the mini mental state examination (mmse) and the montreal cognitive assessment are widely used, but there are drawbacks to their efficient use.There remains a need for a brief and easy method of assessing the activities of daily living (adl) that can be administered to elderly individuals by healthcare workers.We have therefore developed a new scale named the simple observation checklist for activities of daily living (soc-adl).Methods we developed the soc-adl scale as a team of experts engaged in caring for individuals with dementia.This scale comprises eight items and was designed based on the korean instrumental activities of daily living (k-iadl) scale and the barthel activities of daily living scale (barthel index).The new scale was validated by enrolling 176 patients with cognitive dysfunction across 6 centers.Confirmatory factor analysis (cfa) and exploratory factor analysis (efa) were performed.We assessed its concurrent validity by performing comparisons with the korean-mmse, clinical dementia rating, clinical dementia rating-sum of boxes, k-iadl, and barthel index, and its criterion validity by performing comparisons between mild cognitive impairment (mci) and dementia.We also used cronbach's alpha to assess the interitem reliability.The appropriate cutoff values were determined by analyzing receiver operating characteristic curves, including the areas underneath them.Results efa extracted one factor and cfa revealed that all of the model fits exceeded the minimum acceptable criteria.The soc-adl scores were strongly correlated with those of the other tools for dementia and could be used to differentiate mci from dementia.Cronbach's alpha values indicated that the results were reliable.The optimal cutoff value of the soc-adl for discriminating dementia from mci was 3 points, which provided a sensitivity and specificity of 74.5% and 75.7%, respectively.Conclusions our results demonstrate that the soc-adl is a valid and reliable tool for differentiating dementia from mci based on an assessment of adl.This new tool can be used for screening adl in elderly subjects who have difficulty communicating, and to increase the efficiency of dementia screening at the population level.

Journal: Journal of clinical neurology (Seoul, Korea) (2021)
Publication types: Journal Article
The Roles Played by FP/EP3 Receptors During Pressure-lowering in Mouse Eyes Mediated by a Dual FP/EP3 Receptor Agonist.

We investigated the intraocular pressure (iop)-lowering effect of topical sepetaprost (spt), a dual agonist of the fp and ep3 receptors.We explored whether certain receptors mediated the hypotensive effect of spt and outflow facility changes in c57bl/6 mice (wild-type [wt]) and fp and ep3 receptor-deficient mice (fpko and ep3ko mice, respectively).Methods iop was measured using a microneedle.Outflow facility was measured using a two-level, constant-pressure perfusion method.Results spt significantly reduced iop for 8 hours after administration to wt mice.The 2-hour iop reductions afforded by latanoprost were 15.3 ± 2.5, 1.8 ± 2.0, and 12.3 ± 2.4% in wt, fpko, and ep3ko mice, respectively; the spt figures were 13.6 ± 2.1, 5.9 ± 2.7, and 6.6 ± 2.6%, respectively.Latanoprost-mediated iop reduction was significantly decreased in fpko mice, and spt-mediated iop reduction was reduced in both fpko and ep3ko mice.At 6 hours after administration, latanoprost did not significantly reduce the iop in any tested mouse strain.Spt-mediated iop reduction was reduced in both fpko and ep3ko mice.Iop reduction at 6 hours was significantly higher after simultaneous administration of selective fp and ep3 receptor agonists, but iop did not fall on administration of (only) a selective ep3 receptor agonist.Spt significantly increased outflow facility in wt mice, but less so in fpko and ep3ko mice.Conclusions the iop-lowering effect of spt lasted longer than that of latanoprost.Our data imply that this may be attributable to augmented outflow facility mediated by the fp and ep3 receptors.

Journal: Investigative ophthalmology & visual science (2022)
Publication types: Comparative Study;Journal Article;Research Support, Non-U.S. Gov't
Anterior lead location predicts verbal fluency decline following STN-DBS in Parkinson's disease.

Introduction verbal fluency (vf) decline is a well-documented cognitive effect of deep brain stimulation of the subthalamic nucleus (stn-dbs) in patients with parkinson's disease (pd).This decline may be associated with disruption to left-sided frontostriatal circuitry involving the anteroventral non-motor area of the stn.While recent studies have examined the impact of lead location in relation to functional stn subdivisions on vf outcomes, results have been mixed and methods have been limited by atlas-based location mapping.Methods participants included 59 individuals with pd who underwent bilateral stn-dbs.Each participant's active contact location was determined in an atlas-independent fashion, relative to their individual mr-visualized stn midpoint.Multiple linear regression was used to examine lead location in each direction as a predictor of phonemic and semantic vf decline, controlling for demographic and disease variables.Results more anterior lead locations relative to the stn midpoint in the left hemisphere predicted greater phonemic vf decline (b = -2.34, b se = 1.08, β = -0.29, sr2= 0.08).Lead location was not a significant predictor of semantic vf decline.Conclusion using an individualized atlas-independent approach, present findings suggest that more anterior stimulation of the left stn may uniquely contribute to post-dbs vf decline.This is consistent with models in which the anterior stn represents a "non-motor" functional subdivision with connections to frontal regions, e.g., the left dorsal prefrontal cortex.Future studies should investigate the effect of dbs lead trajectory on vf outcomes.

Journal: Parkinsonism & related disorders (2021)
Publication types: Journal Article
COVID-19 guidance for triage of operations for thoracic malignancies: A consensus statement from Thoracic Surgery Outcomes Research Network.

The extraordinary demands of managing the covid-19 pandemic has disrupted the world's ability to care for patients with thoracic malignancies.As a hospital's covid-19 population increases and hospital resources are depleted, the ability to provide surgical care is progressively restricted, forcing surgeons to prioritize among their cancer populations.Representatives from multiple cancer, surgical, and research organizations have come together to provide a guide for triaging patients with thoracic malignancies as the impact of covid-19 evolves as each hospital.

Journal: The Journal of thoracic and cardiovascular surgery (2020)
Publication types: Journal Article;Practice Guideline
One-year hospital readmission for recurrent sepsis: associated risk factors and impact on 1-year mortality-a French nationwide study.

Sepsis is a complex health condition, leading to long-term morbidity and mortality.Understanding the risk factors for recurrent sepsis, as well as its impact on mid- and long-term mortality among other risk factors, is essential to improve patient survival.Methods a risk factor analysis, based on french nationwide medico-administrative data, was conducted on a cohort of patients above 15 years old, hospitalized with an incident sepsis in metropolitan france between 1st january 2018 and 31st december 2018 and who survived their index hospitalization.Two main analyses, focusing on outcomes occurring 1-year post-discharge, were conducted: a first one to assess risk factors for recurrent sepsis and a second to assess risk factors for mortality.Results of the 178017 patients surviving an incident sepsis episode in 2018 and included in this study, 22.3% died during the 1-year period from discharge and 73.8% had at least one hospital readmission in acute care, among which 18.1% were associated with recurrent sepsis.Patients aged between 56 and 75, patients with cancer and renal disease, with a long index hospital stay or with mediastinal or cardiac infection had the highest odds of recurrent sepsis.One-year mortality was higher for patients with hospital readmission for recurrent sepsis (a or 2.93; 99% ci 2.78-3.09).Among all comorbidities, patients with cancer (a or 4.35; 99% ci 4.19-4.52) and dementia (a or 2.02; 99% ci 1.90-2.15) had the highest odds of 1-year mortality.Conclusion hospital readmission for recurrent sepsis is one of the most important risk factors for 1-year mortality of septic patients, along with age and comorbidities.Our study suggests that recurrent sepsis, as well as modifiable or non-modifiable other risk factors identified, should be considered in order to improve patient care pathway and survival.

Journal: Critical care (London, England) (2022)
Publication types: Journal Article
Activation-Induced Cytidine Deaminase Impacts the Primary Antibody Repertoire in Naive Mice.

Genetic and environmental cues shape the evolution of the b cell ig repertoire.Activation-induced cytidine deaminase (aid) is essential to generating ig diversity through isotype class switching and somatic mutations, which then directly influence clonal selection.Impaired b cell development in aid-knockout mice has made it difficult to study ig diversification in an aging repertoire.Therefore, in this report, we used a novel inducible aid-knockout mouse model and discovered that deleting aid in adult mice caused spontaneous germinal center formation.Deep sequencing of the ig h repertoire revealed that ab diversification begins early in life and evolves over time.Our data suggest that activated b cells form germinal centers at steady state and facilitate continuous diversification of the b cell repertoire.In support, we identified shared b cell lineages that were class switched and showed age-dependent rates of mutation.Our data provide novel context to the genesis of the b cell repertoire that may benefit the understanding of autoimmunity and the strength of an immune response to infection.

Journal: Journal of immunology (Baltimore, Md. : 1950) (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Sample adequacy controls for infectious disease diagnosis by oral swabbing.

Oral swabs are emerging as a non-invasive sample type for diagnosing infectious diseases including ebola, tuberculosis (tb), and covid-19.To assure proper sample collection, sample adequacy controls (sacs) are needed that detect substances indicative of samples collected within the oral cavity.This study evaluated two candidate sacs for this purpose.One detected representative oral microbiota (streptococcus species dna) and the other, human cells (human mitochondrial dna, mt dna).Quantitative pcr (q pcr) assays for the two target cell types were applied to buccal swabs (representing samples collected within the oral cavity) and hand swabs (representing improperly collected samples) obtained from 51 healthy u.s.Volunteers.Quantification cycle (cq) cutoffs that maximized youden's index were established for each assay.The streptococcal target at a cq cutoff of ≤34.9 had 99.0% sensitivity and specificity for oral swab samples, whereas human mt dna perfectly distinguished between hand and mouth swabs with a cq cutoff of 31.3.The human mt dna test was then applied to buccal, tongue, and gum swabs that had previously been collected from tb patients and controls in south africa, along with "air swabs" collected as negative controls (total n = 292 swabs from 71 subjects).Of these swabs, 287/292 (98%) exhibited the expected cq values.In a paired analysis the three oral sites yielded indistinguishable amounts of human mt dna, however pur flock tm swabs collected slightly more human mt dna than did omni swabs tm (p = 0.012).The results indicate that quantification of human mt dna cannot distinguish swabs collected from different sites within the mouth.However, it can reliably distinguish oral swabs from swabs that were not used orally, which makes it a useful sac for oral swab-based diagnosis.

Journal: PloS one (2020)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Evaluating different combination methods to analyse ultrasound and shear wave elastography images automatically through discriminative convolutional neural network in breast cancer imaging.

Ultrasound (us) and shear wave elastography (swe) imaging are non-invasive methods used for breast lesion characterization.While us and swe images provide both morphological information, swe visualizes in addition the elasticity of tissue.In this study a discriminative convolutional neural network (dcnn) model is applied to us and swe images and their combination to classify the breast lesions into malignant or benign cases.Furthermore, it is identified whether analysing only the region of the elastogram or including the surrounding b-mode image gives a superior performance.Methods the dataset used in this study consists of 746 images obtained from 207 patients comprising 486 malignant and 260 benign breast lesions.From each image the us and swe image was extracted, once including only the region of the elastogram and once including also the surrounding b-mode image.These four datasets were applied individually to a dcnn to determine their predictive capability.Each the best us and swe dataset were used to examine different combination methods with dcnn.The results were compared to the manual assessment by an expert radiologist.Results the combination of us and swe images with the surrounding b-mode image using two ensembled dcnn models achieved best results with an accuracy of 93.53 %, sensitivity of 94.42 %, specificity of 90.75 % and area under the curve (auc) of 96.55 %.Conclusion this study showed that using the whole us and swe images through dcnn was superior to methods, in which only the region of elastogram was used.Combining breast cancer us and swe images with two ensembled dcnn models in parallel improved the results.The accuracy, sensitivity and auc of the best combination method were significantly superior to the results of using a single dataset through dcnn and to the results of the expert radiologist.

Journal: International journal of computer assisted radiology and surgery (2022)
Publication types: Journal Article
Suicidal Ideation in Bipolar Disorder: The Relation with Clinical and Sociodemographic Variables.

Introduction bipolar disorder (bd) has the highest risk of suicide among all mental disorders.Thus, identifying factors related to suicidal ideation is essential for a better assessment of the risk of suicide in bd.Objective to analyze the relationship between suicidal ideation and clinical and sociodemographic characteristics in bd patients.Method this is a cross-sectional study that included eighty individuals with bd.Information regarding sociodemographic data and history of attempted suicide were collected, and the hamilton depression scale, young mania rating scale, positive and negative syndrome scale/positive symptom subscale, clinical global impressions scale for use in bipolar illness, insight scale for affective disorders, and barratt impulsiveness scale were administered.The presence and severity of suicidal ideation were assessed using the beck scale for suicidal ideation.Results all regression models significantly predicted suicidal ideation.In the model that had the lowest aic score and the highest cross-validity, the severity of depressive and of manic symptoms (standardized β = 0.49, p < 0.001; standardized β = 0.42, p = 0.007), the insight level (standardized β = - 0.38, p = 0.012) and previous suicide attempt (standardized β = 0.20, p = 0.036) acted as predictors of suicidal ideation, while degree of impulsivity (β standardized = 0.13, p = 0.229) and educational level (standardized β = - 0.16, p = 0.108) did not give a significant contribution.Conclusion according to our results, more severe depression and mania symptoms, higher level of insight and a history of suicide attempt indicate the occurrence of suicidal ideation in bd.

Journal: The Psychiatric quarterly (2022)
Publication types: Journal Article
The Lateralization of Resting Motor Threshold to Predict Medication-Mediated Improvement in Parkinson's Disease.

Cortical stimulation patterns in patients with parkinson's disease (pd) are asymmetric and get altered over time.This study examined cortical neurophysiological markers for pd and identified neurophysiological markers for lateralization in pd.We used transcranial magnetic stimulation (tms) to study corticospinal and intracortical excitability in 21 patients with idiopathic pd.We used the movement disorder society unified parkinson's disease rating scale for examination during on and off periods and evaluated inhibitory and facilitatory process markers using tms, including resting motor thresholds (rmt), active motor thresholds, and motor evoked potential amplitude.The rmt in the more affected cortex was significantly shorter than in the less affected cortex, and was strongly correlated with improved motor function following medication.Patients in the tremor group exhibited significantly lower rmt compared to those in the akinetic-rigid group.Cortical electrophysiological laterality observed in patients with pd may be a useful marker for guiding treatment and identifying underlying compensatory mechanisms.

Journal: Brain sciences (2022)
Publication types: Journal Article
Cognitive function in association with high estradiol levels resulting from fertility treatment.

The putative association between hormones and cognitive performance is controversial.While there is evidence that estradiol plays a neuroprotective role, hormone treatment has not been shown to improve cognitive performance.Current research is flawed by the evaluation of combined hormonal effects throughout the menstrual cycle or in the menopausal transition.The stimulation phase of a fertility treatment offers a unique model to study the effect of estradiol on cognitive function.This quasi-experimental observational study is based on data from 44 women receiving ivf in zurich, switzerland.We assessed visuospatial working memory, attention, cognitive bias, and hormone levels at the beginning and at the end of the stimulation phase of ovarian superstimulation as part of a fertility treatment.In addition to inter-individual differences, we examined intra-individual change over time (within-subject effects).The substantial increases in estradiol levels resulting from fertility treatment did not relate to any considerable change in cognitive functioning.As the tests applied represent a broad variety of cognitive functions on different levels of complexity and with various brain regions involved, we can conclude that estradiol does not show a significant short-term effect on cognitive function.

Journal: Hormones and behavior (2021)
Publication types: Journal Article;Observational Study;Research Support, Non-U.S. Gov't
Team-Based Surgical Scheduling for Improved Patient Access in a High-Volume, Tertiary Head and Neck Cancer Center.

Delays in care can lead to inferior survival outcomes in head and neck cancer and other cancers.In the case of malignancies for which surgery is the preferred primary treatment modality, challenges in surgical scheduling can present a major hurdle to initiating definitive therapy in a timely fashion.It is critical to maintain efficient use of operating room resources.Traditionally, surgery is scheduled with the surgeon who initially saw the patient in consultation, and timing of surgery is tightly linked to the availability and operating room block time of the individual surgeon.Methods scheduling of oncologic head and neck surgery was transitioned from a surgeon-specific method to a team-based approach wherein a patient in need of oncologic head and neck surgery is scheduled with the next-available surgeon with appropriate expertise.Results despite substantial growth of our practice, transition to a team-based scheduling approach allowed us to maintain high utilization of operating room block time.Patient and surgeon satisfaction remain high with this new system.Conclusions a team-based surgical scheduling approach can help optimize operating room utilization and minimize delays in cancer care, potentially leading to improved oncologic outcomes.

Journal: Annals of surgical oncology (2022)
Publication types: Journal Article