syedzayyan/paper_mill_benchmark huggingface dataset:
To Summarize and Analyze the Epidemiological Characteristics and Prognostic Risk Factors of Patients with Pelvic Fracture Complicated with Perineal Injury

This study is aimed at summarizing and analyzing the epidemiological characteristics and prognostic risk factors of patients with a pelvic fracture with perineal injury.The clinical data of 153 patients with pelvic fracture with perineal injury treated in our hospital from january 2012 to june 2021 were analyzed retrospectively.The data of sex, age, injury mechanism, pelvic fracture type, shock index (si), perineal wound depth, concomitant injury, total hospital stay, and death were collected by the electronic medical record system.Among the 153 patients, there were 94 males and 59 females, with an average age of (43.2 ± 16.8) years.The cases were mainly concentrated into two age groups: 20–29 years old and 50–59 years old.In a year, pelvic fractures were mainly concentrated in 1–2 months and 11–12 months.In terms of injury time, there were mainly two periods of time in a day: 10 : 00~12 : 00 and 15 : 00~18 : 00.The mots-rts scores of the patients in the undead group and the dead group were (7.12 ± 1.52), (2.69 ± 0.96), iss scores were (27.36 ± 15.84), (61.32 ± 7.08), gcs scores were (12.84 ± 3.69), (4.13 ± 1.25), apach ii scores were (12.87 ± 8.84), (32.41 ± 6.98), and sofa scores were (6.68 ± 5.87), (17.12 ± 3.12).The mots-rts and gcs scores of the nondeath group were significantly higher, while the iss score, apach ii score, sofa score, and shock index were significantly lower.The overall mortality rate of 153 patients was 13.7%.The average area of perineal trauma in undead and dead patients was (54.5 ± 113.52) cm2 and (262.63 ± 300.84) cm2, respectively.The average depth of perineal trauma was (9.63 ± 7.22) cm and (16.23 ± 10.13) cm, respectively.The larger the area of perineal injury and the deeper the depth of perineal trauma, the worse their prognosis.Cox multivariate analysis showed that complications, mots-rts score, iss score, gcs score, perineal trauma area, and perineal trauma depth were independent risk factors affecting the prognosis of patients with pelvic fracture with perineal injury.Most of the patients with pelvic fracture complicated with perineal injury are 20–29 years old and 50–59 years old.The more serious the perineal injury is, the higher the mortality is.The main causes of death are refractory hemorrhagic shock and infection.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Butylphthalide Inhibits TLR4/NF-κB Pathway by Upregulation of miR-21 to Have the Neuroprotective Effect

Stroke is a disease with the highest incidence rate and the highest mortality rate in the world.The study aims to verify the neuroprotective effect of butylphthalide.The mice were divided into sham group, mcao group, and mcao + butylphthalide-treated group.The mice in mcao + butylphthalide-treated group were administered with 70 mg/kg butylphthalide injection intraperitoneally after cerebral ischemia-reperfusion.The normal saline with the same volume was administered intraperitoneally for the mice in the mcao group and sham group.The levels of mi r-21 in brain tissue and cells were detected by q pcr.The ogd/r injury model of neuro2a cells was used to simulate the hypoxic-ischemic environment of neurons in vitro.The proliferation rate of neuro2a cells was detected with cck-8.The production of ros was detected with dcfh-da.Compared with the mice in mcao group, a decrease ( p &lt; 0.01 ) was observed in the functional neurologic impairment scoring, cerebral infarction volume, and brain loss volume in the mice treated with mcao + butylphthalide, but an increase ( p &lt; 0.01 ) was observed in the level of mi r-21, which was positively correlated with functional neurologic impairment scoring (r = −0.8933, p &lt; 0.001 ).Mtt assay showed that the cell viability of ogd/r + butylphthalide group was significantly higher than that of other groups ( p &lt; 0.001 ), and the activity of ros was significantly decreased ( p &lt; 0.001 ).The wb results showed that, compared with ogd/r + mi r-nc and control groups, the ratio of bcl-2/bax in ogd/r + butylphthalide group and ogd/r + mi r-21 mimics group was significantly higher ( p &lt; 0.05 ), while the ratio of caspase-3/gapdh was significantly lower ( p &lt; 0.05 ).In conclusion, butylphthalide has neuroprotective effect on the mouse model of mcao.It may upregulate the level of mi r-21 to inhibit neuronal apoptosis and ros production and improve the proliferation activity.The specific mechanism may lie in inhibiting tlr4/nf-κb pathway.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Analysis of the Management Effect of Cancer Patients after Oral Chemotherapy Based on Nursing Process Reengineering

With the pollution of the environment and the acceleration of the social rhythm, the prevalence of tumors has increased year by year, and tumors have brought huge pain and inconvenience to patients.However, traditional nursing work consumes a lot of manpower and material resources, but it is difficult to improve the happiness of cancer patients, and it also brings a lot of troubles to many nursing workers.Based on the above reasons, we reengineered the traditional nursing process based on the bpr theory and applied the new process to the analysis of the management effect of cancer patients after oral chemotherapy drugs.The data shows that there are 23 patients with no pressure ulcer risk (score greater than 19) before care, 27 patients with low risk (15–19 points), 32 patients with moderate risk (13–14 points), and 18 people at high risk (less than 12 points).After nursing, there were 82 patients with no pressure ulcer risk, 10 patients with low risk, 7 patients with moderate risk, and 1 patient with high risk.This shows that the risk of pressure ulcers in patients with cancer after the use of chemotherapy drugs is significantly reduced compared with those without nursing.Nursing intervention can improve the psychological state of cancer patients during the recovery period, and nursing intervention can promote the compliance of cancer patients in various aspects of rehabilitation.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Role of MiR-27a-3p in Intervertebral Disc Degeneration through Targeting RASSF5 via MST1/LATS1 and RAS/RAC1 Signaling Pathway

The apoptosis of nucleus pulposus (np) cells reduces the number of nucleus pulposus cells in intervertebral disc tissue, resulting in intervertebral disc degeneration (idd).Micro rnas (mi rnas) play an important regulatory role in abnormal cell proliferation and apoptosis.Methods.The mi r-27a-3p expressions in degenerative np tissue and cells were measured via q pcr.The impacts of mi r-27a-3p on the proliferation and apoptosis of human np cells were evaluated by flow cytometry assays, mtt assays, and western blot analyses.In addition, target scan and luciferase reporter assay were applied to confirm that rassf5 was directly binding to mi r-27a-3p.Western blot was applied to assess the relationship between mi r-27a-3p, rassf5 and mst1/lats1, and ras/rac1 signaling pathway.Results.Mi r-27a-3p was downregulated in degenerative np tissues and cells by comparison with the control group.Mi r-27a-3p overexpression enhanced cell proliferation and suppressed apoptosis of np cells, while the above factors showed an opposite tendency after in the mi r-27a-3p inhibitor group.The western blot experiment similarly suggested mir-27a-3p apparently downregulated apoptosis-related proteins (bax and caspase-3) and upregulated antiapoptotic proteins (bcl-2).In addition, rassf5 was confirmed to be directly regulated by mi r-27a-3p using the luciferase reporter assay.Overexpressed rassf5 could reverse the effects caused by mi r-27a-3p mimic.Finally, mi r-27a-3p could downregulate rassf5 and affected the mst1/lats1 and ras/rac1 pathway.Conclusion.Mi r-27a-3p may target rassf5 and enhance cell proliferation and imped cell apoptosis of the nucleus pulposus cells via the mst1/lats1 and ras/rac1 pathway, lessening the degeneration of intervertebral discs.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
The Value of Left Atrial Volume Changes in Predicting Cardiotoxicity in Patients Undergoing Anthracycline Chemotherapy

In order to study the value of left atrial volume three-dimensional echocardiography in predicting cardiotoxicity in patients with multiple myeloma undergoing anthracycline chemotherapy, a total of 53 patients with multiple myeloma who are treated in the department of hematology of our hospital from january 2018 to december 2020 are selected as the research object, and all patients underwent three cycles (t1–t3) of chemotherapy.Before and after each cycle of chemotherapy, the patients are examined with 3d ultrasound and serology detection.These patients are divided into the cardiotoxicity group and noncardiotoxicity group.The serological indexes and three-dimensional echocardiographic parameters between two groups are compared.Multivariate logistic regression is used to determine the independent risk factors of cardiotoxicity in patients undergoing chemotherapy.And roc curves are performed to evaluate the diagnostic value of related indicators in predicting cardiotoxicity.A total of 53 patients with multiple myeloma are included in this study.Serological indexes (t3 c tn i and t3 pro-bnp), t2 lavmin, t3 lavmin, t2 lavprep, and t3 lavprep in the cardiotoxicity group are significantly higher than those in the noncardiotoxicity group.Multivariate logistic regression further found that t3 c tn i, t3 pro-bnp, t2 lavmin, t3 lavmin, t2 lavprep, t3 lavprep could be used to predict the occurrence of cardiotoxicity (p &lt; 0.05).The results of roc curves showed that t3 lavmin had the most diagnostic efficiency of cardiotoxicity (auc = 0.938; sensitivity 75.72%; specificity 93.82%).Detection of changes in left atrial volume using three-dimensional ultrasound could be used as strong predictors of cardiotoxicity caused by anthracycline chemotherapy drugs in patients with multiple myeloma.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Outcome of Extracorporeal Membrane Oxygenation Combined with Intraaortic Balloon Pump Hemodynamic Support during the Percutaneous Coronary Intervention Process for Patients with Cardiac Shock Complicating Acute Myocardial Infarction

We evaluate the effect of extracorporeal membrane oxygenation combined with intraaortic balloon pump mechanical circulatory support for patients with cardiogenic shock complicating acute myocardial infarction during the pci process.Extracorporeal membrane oxygenation combined with intraaortic balloon pump hemodynamic support during the percutaneous coronary intervention process for patients with cardiac shock complicating acute myocardial infarction might play a complementary role.Yet, evidence of application of both devices at the same time remains unclear.Patients with cardiogenic shock complicating myocardial infarction who underwent pci in our hospital from january 2015 to january 2018 were screened.Those who were under hemodynamic support of extracorporeal membrane oxygenation combined with intraaortic balloon pump were enrolled as the ecmo&amp;iabp group, and the patients only under support of intraaortic balloon pump were enrolled as the iabp group.The differences of clinical prognosis between the two groups were compared.A total of 39 patients were enrolled into the study: 10 were in the ecmo&amp;iabp group and 29 in the iabp group.Compared with the iabp group, more patients were complicated with old myocardial infarction (5/10 vs.2/29, p = 0.002 ), more patients were diagnosed as non-st elevated myocardial infarction (8/10 vs.11/29, p = 0.002 ) and left ventricular ejecting fraction was lower (41.1 ± 9.86 vs.48.55 ± 8.86, p = 0.03 ) in the ecmo&amp;iabp group.Mechanical complications were higher in the ecmo&amp;iabp group (5/10 vs.5/29, p = 0.048 ), the survive rate in the ecmo&amp;iabp group is higher than that in the iabp group (90.00% vs.47.83%, p = 0.042 ) at one-year follow-up.Compared with only iabp, ecmo combined with iabp hemodynamic support during the pci process for patients with cardiogenic shock complicating acute myocardial infarction enjoys better mortality outcome.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Mechanism of Dopaminergic Nerve Transmission in Different Doses of Morphine Addiction and Stress-Induced Depression

Depression not only threatens the health and quality of life of patients but also brings a huge mental and economic burden to the patients’ families.This paper mainly studies the mechanism of dopaminergic neurotransmission in different doses of morphine addiction and stress-induced depression.In the experiment, 40 male sd rats were selected.The experiment established a rat model of chronic stress depression.The rats used in this model are all raised in a single cage, and there will be various stimuli every day for 21 days, but high-intensity continuous stimuli must be avoided, and the same stimuli will not appear continuously.The experiment established a depression animal model through chronic unpredictable mild stress (cums), combined with the conditioned position preference (cpp) model of morphine addiction to detect the establishment of cpp in such animals, so as to explore certain stress stimuli or depression, the influence on morphine addiction, and the relationship between them.The second or third branches of pyramidal neurons were selected to analyze the pl and ca3 regions.When analyzing the density of dendrites, each animal selected at least 8 dendrites in order to count the number of dendrites and selected a length of 20 μm on each branch to record the number of dendrites.All measured values are expressed as average ± standard deviation and analyzed by spss17.0 statistical software, and levene test is used in the scattered consistency test.The average niv of pen before injection was 11.92 ± 2.90 hz, and the average latency was 0.16 ± 0.03 s.The results indicate that cums may reduce the conditioned learning and memory ability by damaging the learning loop, rather than affecting the reward loop to weaken the establishment of morphine-dependent cpp.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Analysis of Systolic Blood Pressure Level and Short-Term Variability in Masked Hypertension

Patients with masked hypertension are at an elevated risk of cardiovascular events and all-cause death.This risk is close to that of sustained hypertension.The mean value and short-term variability of systolic blood pressure are considered to be risk factors for organ damage in hypertension.Objective.To investigate the mean value and short-term variability of systolic blood pressure in patients with masked hypertension.Methods.According to the results of in-clinic and ambulatory blood pressure measurement, participants were divided into four groups: normotension group, controlled hypertension group, masked hypertension group, and sustained hypertension group.The mean value and short-term variability of systolic blood pressure of masked hypertension group were evaluated by comparison with the other three groups.Results.A total of 250 subjects were enrolled, with an average age of 65.46 ± 8.76 years, and 166 (66.4%) were male, including 62 in the normotension group, 78 in the controlled hypertension group, 69 in the masked hypertension group, and 41 in the sustained hypertension group.Compared with the normotension group and controlled hypertension group, the mean value, blood pressure load, standard deviation, and coefficient of variation of systolic blood pressure over 24 hours and during the day and night, were all higher in the masked hypertension group ( p &lt; 0.05 ), while the rate of the nocturnal systolic blood pressure decline was lower ( p &lt; 0.05 ).There were no statistically significant differences in the above indexes between the masked hypertension group and sustained hypertension group ( p &gt; 0.05 ).Conclusion.There are higher mean value of systolic blood pressure and greater short-term variability in masked hypertension patients.Identification of masked hypertension is an important challenge in the clinic.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Application of Image Processing Variation Model Based on Network Control Robot Image Transmission and Processing System in Multimedia Enhancement Technology

The rapid development of the information age brings convenience to human life, but it also brings great challenges to information processing technology.Multimedia enhancement technology is an organic combination of multimedia technology and information processing technology, and it is also an important way of modern multimedia image information processing.However, its usefulness and effectiveness are increasingly negatively affected by the open information environment.The processing effect is also unable to meet the development requirements of the visual field.In order to improve this problem, this paper studied the image transmission and processing system of network-controlled robot on the basis of analyzing the characteristics of the problems existing in the current stage of multimedia technology.On this basis, a new image processing variational model was established and applied to multimedia enhancement technology, which improved the efficiency and effect of image information processing.Finally, the feasibility of its application function and performance was tested by experiments.The test results showed that in the difficult mode of the image processing task, the refresh time of the model in this paper in the multimedia enhancement technology was 1.13 s in total, which was not much different from the test results in the easy mode.Also, in the load stress test, the comprehensive test values under full-function operation and partial-function operation were 42.04% and 20.92%, respectively.Compared with the traditional model, the model in this paper has stronger carrying capacity in multimedia enhancement technology and has better processing ability and stability.

Journal: Journal of Robotics (2022)
Publication types: Research Article;
Clinical Characteristics of Metastatic Colorectal Cancer Combined with Gastrointestinal Perforation and Prognostic Value of Circulating Tumor DNA

To explore the clinical characteristics of metastatic colorectal cancer combined with gastrointestinal perforation and the prognostic value of circulating tumor dna (ct dna).Methods.A total of 97 patients with metastatic colorectal cancer and gastrointestinal perforation were enrolled as the research objects between february 2016 and january 2019.Their clinicopathological characteristics were statistically analyzed.Patients were divided into the death group (n = 78) and the survival group (n = 19) according to their survival status at 3 years after surgery.The ct dna level between the two groups was compared.Also, its evaluation value on patient prognosis was analyzed.The survival time in patients with different levels of ct dna was compared.Results.The clinical staging was stage t4 in patients with metastatic colorectal cancer combined with gastrointestinal perforation, including 70 cases (72.16%) aged ≥60 years and 27 cases (27.84%) &lt;60 years.There were 61 males (62.89%) and 36 females (37.11%).There were 27 cases (27.84%) with primary site at left colon, 59 cases (60.82%) at right colon and 11 cases (11.34%) at rectum.There were 56 cases (57.73%) with number of metastatic organs ≥2 and 41 cases (42.27%) &lt;2.There were 58 cases (59.79%) treated with vegf inhibitor before perforation, 40 cases (41.24%) with lung metastasis, 72 cases (74.23%) with liver metastasis, 30 cases (30.93%) with pelvic metastasis, 24 cases (24.74%) with distant lymph node metastasis, 56 cases (57.73%) with obstruction, and 35 cases (36.08%) with diverticulum.According to survival status at 3 years after after surgery, patients were divided into the death group (n = 78) and the survival group (n = 19).The level of plasma ct dna in the death group was higher than that in the survival group ( p &lt; 0.05 ).The area under curve (auc) of ct dna for predicting survival of patients was 0.806.According to ct dna expression, patients were divided into the high expression group (n = 57) and the low expression group (n = 40).The survival rate in the high expression group was lower than that in the low expression group (7.02% (4/57) vs 36.38% (15/40)) ( p &lt; 0.001 ).The median survival time for the two groups was 18.20 and 28.10 months, respectively.Conclusion.Clinical characteristics of metastatic colorectal cancer combined with gastrointestinal perforation include elderly age, obstruction, and diverticulum.The expression of ct dna has evaluation value for prognosis of patients.

Journal: Emergency Medicine International (2022)
Publication types: Clinical Study;Research Article;
Forecasting the Applied Deep Learning Tools in Enhancing Food Quality for Heart Related Diseases Effectively: A Study Using Structural Equation Model Analysis

The term heart-related disease is stated as the range of condition that impacts an individual heart negatively.In the current scenario, cardiovascular diseases are causing more deaths when compared with other ailments, it has been estimated that there are nearly 18 million deaths annually as per the recent report released by world health organization (who).It has been stated that unhealthy habits and other related aspects adopted by individuals are considered as the primary reasons for an increase in the risk of heart diseases.High cholesterol, eating more junk foods, hypertension, etc., created the issue related to heart diseases.Hence, addressing food quality and suggesting better eating habits enable individuals to enhance their living and support better health.The application of new technologies like machine learning, deep learning, and other models support doctors, nurses, and radiologists to predict heart disease effectively.Studies have stated that the various models are used mainly for the classification and forecasting of the diagnosis of heart-related diseases.The researchers have identified that critical algorithms like cart support the predictability of the disease by 93.3% whereas the conventional models possess vert less specificity.Furthermore, deep neural networks can be applied for analyzing and detecting heart failures effectively and supporting medical practitioners in making better and more critical clinical decisions making.The researchers focus on using a descriptive research study for performing the study; moreover, the researcher collates the data using the questionnaire method, which enables sourcing the critical information from the medical practitioners and supports in making critical data analysis effectively.The researchers also use secondary data modes for sourcing the information related to past studies on the related topic.The researchers use the frequency analysis, correlation analysis, and structural equation model analysis for performing the study, and the results are stated in detail in the respective sections.

Journal: Journal of Food Quality (2022)
Publication types: Research Article;