syedzayyan/paper_mill_benchmark huggingface dataset:
Adoption of a deep learning-based neural network model in the psychological behavior analysis of resident tourism consumption.

With the development of society and the continuous progress of science and technology, it has become the mainstream measure to promote the development of the social economy through science and technology.Therefore, to improve the current situation of tourism consumption, improve the consumer sentiment of tourists, and promote the development of the tourism economy, the convolutional neural network (cnn) technology model is used to analyze the tourist's consumer psychology and behavior.Based on this, the user's consumption situation is analyzed, thus providing support for the intelligent improvement of tourism consumption.First, the basic characteristics of tourism consumption mood and behavior are introduced, and the methods to improve the tourism consumption mood and behavior are briefly introduced.Then, the cnn algorithm is employed to identify consumers' travel consumption behaviors and emotions.To improve the recognition effect, the algorithm is combined with skeleton node behavior recognition and video image behavior recognition.Finally, the performance of the designed algorithm is tested.The accuracy of the human behavior recognition (hbr) algorithm is more than 0.88.Compared with the detection effect of the hbr algorithm, the combined algorithm adopted in this work can reduce the image processing time and improve the detection efficiency.The multithread method can effectively reduce the complexity of the model and improve the recognition accuracy.The test results on different data sets show that the proposed algorithm can better adapt to the changes in identification samples and obtain more accurate recognition results compared with similar algorithms.In summary, this study not only provides technical support for the rational analysis of consumer sentiment and consumer behavior but also contributes to the comprehensive development of the tourism market.

Journal: Frontiers in public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
ULK1 Suppresses Osteoclast Differentiation and Bone Resorption via Inhibiting Syk-JNK through DOK3.

Bone resorption diseases, including osteoporosis, are usually caused by excessive osteoclastogenesis.Unc-51-like autophagy activating kinase 1 (ulk1), a mammalian serine/threonine kinase, may participate in the regulation of bone homeostasis and osteolytic metastasis.In this study, ulk1 expression during osteoclastogenesis was detected with rt-pcr.We knocked down or overexpressed ulk1 through si rna or lentiviral transduction in bone marrow macrophage (bmm).Trap and phalloidin staining were performed to detect the osteoclastogenesis activity.Ovariectomized (ovx) mouse model of osteoporosis and a mouse of model osteoclast-induced bone resorption were applied to explore the role of ulk1 in bone resorption in vivo.The results showed that ulk1 expression was downregulated during osteoclast differentiation and was clinically associated with osteoporosis.Ulk1 inhibited osteoclast differentiation in vitro.Knockdown of ulk1 expression activated phosphorylation of c-jun n-terminal kinase (jnk) and spleen tyrosine kinase (syk).Docking protein 3 (dok3) was coexpressed with ulk1 during osteoclastogenesis.Downregulation of dok3 offsets the effect of ulk1 on osteoclastogenesis and induced phosphorylation of jnk and syk.Activation of ulk1 impeded bone loss in ovx mice with osteoporosis.Additionally, upregulation of ulk1 inhibited osteoclast-induced bone resorption in vivo.Therefore, our study reveals a novel ulk1/dok3/syk axis that regulates osteoclast differentiation and bone resorption, and targeting ulk1 is a potential therapeutic strategy for osteoporosis.

Journal: Oxidative medicine and cellular longevity (2021)
Publication types: Journal Article
Introduction of Plasmid to the Murine Gut via Consumption of anEscherichia coliCarrier and Examining the Impact of Bacterial Dosing and Antibiotics on Persistence.

We examine the impacts of dosing strategies of plasmids on bacterial communities in the murine gut by measuring the quantity of plasmids in mouse feces.Methods we fed mice carrier bacteria,e.Coli, that contain plasmids with both a reporter gene and an antibiotic resistant gene.We varied the quantity of the plasmid-carrying bacteria and the length of time the mice consumed the bacteria.We also pretreated the gut with broad-spectrum antibiotics and used continuous antibiotic treatment to investigate selection pressure.We collected bacteria from fecal pellets to quantify the number of plasmid-carrying bacteria via plate assay.Results dosing regimens with plasmid-carrying bacteria resulted in a significantly increased duration of persistence of the plasmid within the gut when supplemented continuously with kanamycin during as well as after completion of bacterial dosing.The carrier bacteria concentration influenced the short-term abundance of carrier bacteria.Conclusion we evaluated the persistence of plasmid-carrying bacteria in the murine gut over time using varying dosage strategies.In future work, we will study how bacterial diversity in the gut impacts the degree of plasmid transfer and the prevalence of plasmid-carrying bacteria over time.Lay summary observing how plasmids persist within the gut can help us understand how newly introduced genes, including antibiotic resistance, are transmitted within the gut microbiome.In our experiments, mice were given bacteria containing a genetically engineered plasmid and were examined for the persistence of the plasmid in the gut.We found long-term persistence of the plasmid in the gut when administering antibiotics during and following dosing of the mice with bacteria carrying the plasmid.The use of higher concentrations of carrier bacteria influenced the short-term abundance of the plasmid-carrying bacteria in the gut.Description of future works building on evidence from these initial studies that persistence of plasmids within the gut can be regulated by the dosage strategy, we will explore future studies and models of gene uptake in the context of spatial and taxonomic control and further determine if dosing strategies alter the compositional diversity of the gut microbiome.Graphical abstract

Journal: Regenerative engineering and translational medicine (2022)
Publication types: Journal Article
Device-related risk of atrial fibrillation after closure of patent foramen ovale: a systematic review and meta-analysis.

Atrial fibrillation (af) represents a frequent complication in patients after interventional closure of patent foramen ovale (pfo).We aimed to compare the incident rate and risk of af between amplatzer pfo and gore (helex and cardioform septal occluder) device by analyzing the data from randomized trials.Methods we included all randomized studies which reported the rate of af after pfo closure using amplatzer or gore occluder in patients suffering cryptogenic stroke and compared the risk of af between the two devices.Pub med and cochrane library were searched for eligible studies published until july 2020.Results rate of all cases of incident af from randomized trials with amplatzer in the interventional group was 3.93% (30/763) vs.1.46% (11/751) in the respective medical group (rr of 2.57, 95% ci 1.31-5.03, p = 0.006).The incidence of incident af from randomized trial with gore device was 6.57% (29/441) vs.0.44% (1/223) in the respective medical group (rr of 14.66, 95% ci 2.01-106.95, p = 0.008).The p for interaction between the two devices regarding risk of af was 0.10.Conclusions the results suggest lower risk expressed by lower rate of incident af after pfo closure using amplatzer pfo occluder when compared with gore occluder.However, these findings are derived from secondary analyses and should be scrutinized using appropriate screening tool for af following pfo closure in adequately powered randomized clinical trial with a head-to-head design that compares the two devices.

Journal: Clinical research in cardiology : official journal of the German Cardiac Society (2022)
Publication types: Journal Article;Meta-Analysis;Systematic Review
Expectation of irrelevant novel stimuli has no consistent effect on recognition memory.

Novelty is defined as the part of an experience that is not yet represented by memory systems.Novelty has been claimed to exert various memory-enhancing effects.A pioneering study by wittmann et al.(2007) has shown that memory formation may even benefit from the expectation of novelty.We aimed to replicate this assumed memory effect in four behavioral studies.However, our results do not support the idea that anticipated novel stimuli are more memorable than unexpected novelty.In our experiments, we systematically manipulated the novelty predicting cues to ensure that the expectations were correctly formed by the participants, however, the results showed that there was no memory enhancement for expected novel pictures in any of the examined indices, thus we could not replicate the main behavioral finding of wittmann et al.(2007).These results call into question the original effect, and we argue that this fits more into current thinking on memory formation and brain function in general.Our results are more consistent with the view that unexpected stimuli are more likely to be retained by memory systems.Predictive coding theory suggests that unexpected stimuli are prioritized by the nervous system and this may also benefit memory processes.Novel stimuli may be unexpected and thus recognized better in some experimental setups, yet novelty and unexpectedness do not always coincide.We hope that our work can bring more consistency in the literature on novelty, as educational methods in general could also benefit from this clarification.

Journal: Scandinavian journal of psychology (2022)
Publication types: Journal Article
Triglyceride-glucose index is associated with quantitative flow ratio in patients with acute ST-elevation myocardial infarction after percutaneous coronary intervention.

The triglyceride-glucose (ty g) index is a novel marker representing the degree of insulin resistance (ir) and is closely related to cardiovascular diseases.However, the association between the ty g index and vascular function in patients with acute st-elevation myocardial infarction (stemi) after percutaneous coronary intervention (pci) remains unknown.Materials and methods this study was apost hocanalysis of a multicenter, prospective cohort study.In this study, patients with stemi who underwent pci were included, and coronary angiography data were analyzed by quantitative coronary angiography (qca) and quantitative flow ratio (qfr).In addition, the ty g index was calculated as follows: ln [fasting triglyceride (mg/dl) × fasting blood glucose (mg/dl) × 1/2].According to the post-pci qfr, patients were divided into two groups: post-pci qfr ≤ 0.92 group and post-pci qfr > 0.92 group.Construction of logistic regression model to explore the relationship between the ty g index and post-pci qfr.Results a total of 241 stemi patients were included in this study.Compared with patients in the post-pci qfr > 0.92 group, the ty g index was higher in the post-pci qfr ≤ 0.92 group.Logistic regression model showed that after adjusting for other confounding factors, the ty g index was positively correlated with the risk of post-pci qfr ≤ 0.92 (or = 1.697, 95% ci 1.171-2.460,p= 0.005).Restricted cubic splines showed the cutoff value of ty g index associated with post-pci qfr ≤ 0.92 risk was 9.75.Conclusion the ty g index was associated with the risk of post-pci qfr ≤ 0.92 in stemi patients.The risk of post-pci qfr ≤ 0.92 increased when the ty g index exceeded 9.75.

Journal: Frontiers in cardiovascular medicine (2022)
Publication types: Journal Article
Impact of antigen test target failure and testing strategies on the transmission of SARS-CoV-2 variants.

Population testing remains central to covid-19 control and surveillance, with countries increasingly using antigen tests rather than molecular tests.Here we describe a sars-co v-2 variant that escapes n antigen tests due to multiple disruptive amino-acid substitutions in the n protein.By fitting a multistrain compartmental model to genomic and epidemiological data, we show that widespread antigen testing in the italian region of veneto favored the undetected spread of the antigen-escape variant compared to the rest of italy.We highlight novel limitations of widespread antigen testing in the absence of molecular testing for diagnostic or confirmatory purposes.Notably, we find that genomic surveillance systems which rely on antigen population testing to identify samples for sequencing will bias detection of escape antigen test variants.Together, these findings highlight the importance of retaining molecular testing for surveillance purposes, including in contexts where the use of antigen tests is widespread.

Journal: Nature communications (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
In vitro growth (IVG) of human ovarian follicles in frozen thawed ovarian cortex tissue culture supplemented with follicular fluid under hypoxic conditions.

Despite its clinical success rates, transplantation after ovarian tissue cryopreservation (otc) remains a matter of concern.Certain cancer subtypes may lead to the transfer of malignant cells when transplantation of affected ovarian tissue is conducted.Ivg and subsequent isolation of vital follicles obtained from frozen thawed ovarian tissue for further in vitro maturation (ivm) would expand current fertility protection techniques while reducing the risk of retransplanting malignant cells.Methods a total of 216 cortical biopsies from 3 patients were included in this study in 4 treatment groups.After freezing, thawing and 8 days of hypoxic tissue culture supplemented with different concentrations of human follicular fluid (hu ff) and follicle-stimulating hormone (fsh), follicles were isolated enzymatically and stained with calcein to determine follicular viability.Numbers and size of vital follicles were assessed by fluorescence microscopy (ti2, nikon) and specified by computer assisted, semi-automated measurement (nis software, nikon).To estimate the effect of in vitro culture on apoptosis, tissue sections were stained for nicked dna (tunel) prior and after tissue culture.Results analysing 3025 vital follicles, we observed significant differences [p 100 μm.Conclusions the results implicate that hu ff contains valuable factors contributing to significant ivg of follicles in human ovarian tissue and could be regarded as an additional tool in personalized fertility restoration prior to retransplantation of ovarian tissue.

Journal: Archives of gynecology and obstetrics (2022)
Publication types: Journal Article
Emergence of mesoscale quantum phase transitions in a ferromagnet.

Mesoscale patterns as observed in, for example, ferromagnets, ferroelectrics, superconductors, monomolecular films or block copolymers1,2reflect spatial variations of a pertinent order parameter at length scales and time scales that may be described classically.This raises the question for the relevance of mesoscale patterns near zero-temperature phase transitions, also known as quantum phase transitions.Here we report the magnetic susceptibility of li ho f4-a dipolar ising ferromagnet-near a well-understood transverse-field quantum critical point (tf-qcp)3,4.When tilting the magnetic field away from the hard axis such that the ising symmetry is always broken, a line of well-defined phase transitions emerges from the tf-qcp, characteristic of further symmetry breaking, in stark contrast to a crossover expected microscopically.We show that the scenario of a continuous suppression of ferromagnetic domains, representing a breaking of translation symmetry on mesoscopic scales in an environment of broken magnetic ising symmetry on microscopic scales, is in excellent qualitative and quantitative agreement with the field and temperature dependence of the susceptibility and the magnetic phase diagram of li ho f4under tilted field.This identifies a new type of phase transition that may be referred to as mesoscale quantum criticality, which emanates from the textbook example of a microscopic ferromagnetic tf-qcp.Our results establish the surroundings of quantum phase transitions as a regime of mesoscale pattern formation, in which non-analytical quantum dynamics and materials properties without classical analogue may be expected.

Journal: Nature (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Retro-odontoid pseudotumor with uncommon presentation of cervical spine injury.

We report the first case of retro-odontoid pseudotumor with an isolated symptom of c2-c3 dysesthesia triggered by a traumatic event.Case presentation an 86-year-old man, who was a wood craftsman for more than 50 years, presented to the emergency room with sudden-onset severe posterior head and neck dysesthesia after accidentally falling backward.No neurological impairment of the extremities was noted.Computed tomography revealed a c2-c7 osteophyte formation, mainly in front of the vertebral bodies.Moreover, magnetic resonance imaging showed cervical spinal cord compression by a soft tissue mass posterior to the odontoid process of the axis.Therefore, we diagnosed a cervical spine injury with an isolated symptom of c2-c3 dysesthesia due to a retro-odontoid pseudotumor.He did not undergo surgical intervention and was transferred to a rehabilitation hospital on day 11 for pain control.Conclusion our report could be useful to emergency physicians dealing with similar cases of cervical symptoms following trauma.

Journal: Acute medicine & surgery (2021)
Publication types: Case Reports;Journal Article
"Under the Bridge": Looking for Ischemia in a Patient with Intramyocardial Coronary Artery Course-The Role of the Cardiopulmonary Exercise Test.

Many variables obtained during cardiopulmonary exercise test (cpet), including o2uptake (vo2) versus heart rate (hr, o2-pulse) and work rate (vo2/watt), provide quantitative patterns of responses to exercise when left ventricular dysfunction is an effect of myocardial ischemia (mi).Therefore, cpet offers a unique approach to evaluate exercise-induced mi in the presence of fixed or dynamic coronary arteries stenosis.In this paper, we examined the case of a 74-year-old patient presenting with an ischemic cpet and a normal stress cardiac magnetic resonance (cmr) with dipyridamole.A coronary angiography demonstrated the presence of myocardial bridging (mb), a well-known congenital coronary anomaly that is able to generate mi during exercise (but not in provocative testing using coronary artery vasodilators, such as dipyridamole).Despite the good diagnostic accuracy of the imaging methods (i.e., stress cmr) in mi detection, this case shows that exercise should be the method of choice in elicit ischemia in specific cases, like mb.

Journal: Journal of clinical medicine (2023)
Publication types: Case Reports;Journal Article
Clinically relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance.

Chemotherapy resistance and relapses are common in high-risk neuroblastoma (nb).Here, we developed a clinically relevant in vivo treatment protocol mimicking the first-line five-chemotherapy treatment regimen of high-risk nb and applied this protocol to mice with mycn-amplified nb patient-derived xenografts (pdxs).Genomic and transcriptomic analyses were used to reveal nb chemoresistance mechanisms.Intrinsic resistance was associated with high genetic diversity and an embryonic phenotype.Relapsed nb with acquired resistance showed a decreased adrenergic phenotype and an enhanced immature mesenchymal-like phenotype, resembling multipotent schwann cell precursors.Nbs with a favorable treatment response presented a lineage-committed adrenergic phenotype similar to normal neuroblasts.Novel integrated phenotypic gene signatures reflected treatment response and patient prognosis.Nb organoids established from relapsed pdx tumors retained drug resistance, tumorigenicity, and transcriptional cell states.This work sheds light on the mechanisms of nb chemotherapy response and emphasizes the importance of transcriptional cell states in chemoresistance.

Journal: Science advances (2022)
Publication types: Journal Article
Control of Oxygen Vacancy Ordering in Brownmillerite Thin Films via Ionic Liquid Gating.

Oxygen defects and their atomic arrangements play a significant role in the physical properties of many transition metal oxides.The exemplary perovskite sr co o3-δ(p-sco) is metallic and ferromagnetic.However, its daughter phase, the brownmillerite sr co o2.5(bm-sco), is insulating and an antiferromagnet.Moreover,bm-sco exhibits oxygen vacancy channels (ovcs) that in thin films can be oriented either horizontally (h-sco) or vertically (v-sco) to the film's surface.To date, the orientation of these ovcs has been manipulated by control of the thin film deposition parameters or by using a substrate-induced strain.Here, we present a method to electrically control the ovc ordering in thin layers via ionic liquid gating (ilg).We show that h-sco (antiferromagnetic insulator, afi) can be converted to p-sco (ferromagnetic metal, fm) and subsequently to v-sco (afi) by the insertion and subtraction of oxygen throughout thick films via ilg.Moreover, these processes are independent of substrate-induced strain which favors formation of h-sco in the as-deposited film.The electric-field control of the ovc channels is a path toward the creation of oxitronic devices.

Journal: ACS nano (2022)
Publication types: Journal Article
Fatty acids produced by the gut microbiota dampen host inflammatory responses by modulating intestinal SUMOylation.

The gut microbiota produces a wide variety of metabolites, which interact with intestinal cells and contribute to host physiology.The effect of gut commensal bacteria on host protein sumoylation, an essential ubiquitin-like modification involved in various intestinal functions, remains, however, unknown.Here, we show that short chain fatty acids (scfas) and branched chain fatty acids (bcfas) produced by the gut microbiota increase protein sumoylation in intestinal cells in a p h-dependent manner.We demonstrate that these metabolites inactivate intestinal de sumoylases and promote the hyper sumoylation of nuclear matrix-associated proteins.We further show that bcfas inhibit the nf-κb pathway, decrease pro-inflammatory cytokine expression, and promote intestinal epithelial integrity.Together, our results reveal that fatty acids produced by gut commensal bacteria regulate intestinal physiology by modulating sumoylation and illustrate a new mechanism of dampening of host inflammatory responses triggered by the gut microbiota.

Journal: Gut microbes (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Eating disorders in adolescents with type 1 diabetes: Challenges in diagnosis and treatment.

Eating disorders (ed) are characterized by a persistent disturbance of eating that impairs health or psychosocial functioning.They are associated with increased rates of medical complications and mortality.Insulin omission is a unique purging behavior available to individuals with type 1 diabetes mellitus (t1dm).The standard treatment regimen for t1dm requires a major focus on food and eating patterns.Moreover, intensive insulin therapy is associated with increasing body weight.These factors, combined with the psychological burden of chronic disease management and depression, may contribute to ed.The comorbidity of ed in t1dm patients is associated with poorer glycemic control and consequently higher rates of diabetes complications.Early recognition and adequate treatment of ed in t1dm is essential.

Journal: World journal of diabetes (2015)
Publication types: Journal Article;Review