syedzayyan/paper_mill_benchmark huggingface dataset:
Ableism and Contours of the Attitudinal Environment as Identified by Adults with Long-Term Physical Disabilities: A Qualitative Study.

Adults with physical disabilities experience a continuum of enabling and disabling attitudes in the environment.This study identified where adults with physical disabilities experience the attitudinal environment, the continuum of those attitudes, and how they impact emotional and psychological health and well-being.Focus groups and interviews were conducted in 2019 and 2020 with adults with physical disabilities in southeastern michigan in the united states.Participants discussed environmental factors that impact healthy aging.From an initial thematic coding of narratives, the attitudinal environment was identified.Transcripts were recoded and analyzed focusing on societal attitudes.Qualitative analyses revealed that participants did not experience societal attitudes as simply positive or negative, and that the contexts in which these attitudes were expressed were not limited to interpersonal interactions.Rather, these attitudes were also experienced in the built environment and through social institutions and organizations and their programs, systems, and structures that provide or deny needed accommodations, resources, and support.The spectrum of overlapping attitudes that participants articulated ranged from understanding and supportive, to not understanding, to being viewed and treated as less than human.Societal structures reflect and influence societal attitudes and have material consequences on the lives of adults with physical disabilities.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.;Research Support, Non-U.S. Gov't
Spatial distribution, sources and risk assessment of potentially toxic elements contamination in surface soils of Yellow River Delta, China.

The contamination status and ecological risk of soil potentially toxic elements (ptes) in yellow river delta (yrd) are still poorly understood.Thirty surface soil samples were collected in yrd, determined for contents of ptes, and assessed using four kinds of proxies.Results indicated that ptes contents basically met the environmental quality standard for soils, and spatial heterogeneity of ptes was not distinctive except for a few sampling sites.Results of geo-accumulation index (igeo) and enrichment factor (ef) indicated significant enrichment of as and sb in yrd.The multivariate analysis results distinguished the possible sources of these ptes and demonstrated that sources of ag, as, cd, cu, pb, sb and zn could be influenced by anthropogenic activities (industrial and agricultural sources).Moreover, ni, cr and as had relatively high contributions to sum of toxicity units (σtus).This study provides basic information for understanding soil ptes contamination status of yrd.

Journal: Marine pollution bulletin (2022)
Publication types: Journal Article
In vitroProperties of Methanol Extract and Sodium Alginate ofSargassum polycystumC. Agardh Brown Seaweed Collected from Malaysia.

The edible brown seaweed,sargassum polycystum c.Agardh was harvested from the coastal region of malaysia.In this study, analysis of the nutrition and metal content in the methanol extract showed positive for sodium, potassium, magnesium, vitamins a and e and arsenic contamination.The brine shrimp lethality assay (bsla) revealed the extract to be non-toxic with lc50value of 15.60 mg m l-1(lc50> 1).The antioxidant and antibacterial activities of the methanol extract were measured through various bioassays.The structural and physicochemical characterisation of the na alg, analysed through the1h-nmr analysis revealed the m:g ratio of na alg at 0.733 with mannuronic (m) and guluronic (g) fractions at fm= 0.423 and fg= 0.577, respectively.The degraded na alg through methods of ultraviolet irradiation and sonication showed an increment in thein vivoantioxidant activities at intervals of 15 min, 30 min, 60 min, 90 min and 120 min.The fourier transform infrared spectroscopy (ftir) spectra of polysaccharides taken before and after uv irradiation showed breakage of covalent bonds and thus, increase in the intensity of both o-h and c-o stretching vibrations.Therefore, the increment in antioxidant activities observed in the treated samples were related to changes seen in their molecular structures.

Journal: Tropical life sciences research (2022)
Publication types: Journal Article
Bacillus amyloliquefaciens strain QST713 may contribute to the management of SDHI resistance in Botrytis cinerea.

Resistance of botrytis cinerea to sdhi fungicides is widely distributed throughout the world and is associated with mutations in sdh b, differentially affecting mutant sensitivity to several succinate dehydrogenase inhibitors (sdhi) and the fitness of the strains.This study was initiated to test the hypothesis that bacillus amyloliquefaciens qst713 (ba qst713) can be utilized in integrated pest management (ipm) programs aiming to control grey mould and eliminate sdh b mutants (h272r/y, n230i and p225f/h/l).Results protective and curative applications of ba qst713 on artificially inoculated bean plants resulted in a significant reduction of disease incidence and severity.Competition experiments between sdh b mutants and wild-type isolates conducted either in the absence of any treatment or in the presence of ba qst713 or fluopyram showed a dominance of sensitive strains over the mutated strains on untreated and ba qst713-treated plants.Additionally, the efficacy of ba qst713 in controlling grey mould and its effects on the selection of sdh b mutants was assessed in a greenhouse experiment.The applications of ba qst713 in alternation schemes with fluopyram provided high control efficacy and reduced sdhi resistance frequency.Conclusions the results of the study showed that ba qst713 can contribute both to moderate/high levels of grey mould suppression and to a reduction in sdhi resistance frequency.Thus, ba qst713 can be an efficient tool for sdhi resistance management of b.Cinerea in the field.© 2020 society of chemical industry.

Journal: Pest management science (2021)
Publication types: Journal Article
Prediction of clinical outcomes in women with placenta accreta spectrum using machine learning models: an international multicenter study.

Introduction placenta accreta spectrum is a major obstetric disorder that is associated with significant morbidity and mortality.The objective of this study is to establish a prediction model of clinical outcomes in these women.Materials and methods pas-id is an international multicenter study that comprises 11 centers from 9 countries.Women who were diagnosed with pas and were managed in the recruiting centers between 1 january 2010 and 31 december 2019 were included.Data were reanalyzed using machine learning (ml) models, and 2 models were created to predict outcomes using antepartum and perioperative features.Ml model was conducted using python®programing language.The primary outcome was massive pas-associated perioperative blood loss (intraoperative blood loss ≥2500 ml, triggering massive transfusion protocol, or complicated by disseminated intravascular coagulopathy).Other outcomes include prolonged hospitalization >7 days and admission to the intensive care unit (icu).Results 727 women with pas were included.The area under curve (auc) for ml antepartum prediction model was 0.84, 0.81, and 0.82 for massive blood loss, prolonged hospitalization, and admission to icu, respectively.Significant contributors to this model were parity, placental site, method of diagnosis, and antepartum hemoglobin.Combining baseline and perioperative variables, the ml model performed at 0.86, 0.90, and 0.86 for study outcomes, respectively.Ethnicity, pelvic invasion, and uterine incision were the most predictive factors in this model.Discussion ml models can be used to calculate the individualized risk of morbidity in women with pas.Model-based risk assessment facilitatesa prioridelineation of management.

Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2022)
Publication types: Multicenter Study;Journal Article
ENETS standardized (synoptic) reporting for radiological imaging in neuroendocrine tumours.

This expert consensus document represents an initiative by the european neuroendocrine tumor society (enets) to provide guidance for synoptic reporting of radiological examinations critical to the diagnosis, grading, staging and treatment of neuroendocrine neoplasms (nens).Template drafts for initial tumor staging and follow-up by computed tomography (ct) and magnetic resonance imaging (mri) were established, based on existing institutional and organisational reporting templates relevant for nen imaging, and applying the rad lex lexicon of radiological information (radiological society of north america), for consistency regarding the radiological terms.During the enets scientific advisory board meeting 2018, the template drafts were subject to iterative interdisciplinary discussions among experts in imaging, surgery, gastroenterology, oncology and pathology.Members of the imaging group stated a strong preference for a combination of limited and standardised options by way of drop-down menus.Separate templates were produced for the initial work-up and for follow-up, respectively.To provide a detailed description of the radiological findings of the primary tumor and its local extension and spread, different templates were developed for bronchial, pancreatic and gastrointestinal nens for ct and mri, respectively.Each template was structured in 10 sections: clinical details, comparative imaging modality, acquisition technique, primary tumor findings, regional lymph node metastases, distant metastases, tnm classification, reference lesions according to recist 1.1, additional findings and conclusion.Two templates were developed for follow-up, for ct and mri, respectively, and were specifically focused on assessment of therapy response.These included a qualitative response assessment, such as decrease of vascularisation and presence of necrosis, and a quantitative assessment according to recist 1.1 and the modified recist (m recist) for assessing tumor response following transarterial chemoembolisation.

Journal: Journal of neuroendocrinology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Options to Reform the European Union Legislation on GMOs: Risk Governance.

Here, we discuss options to reform the eu genetically modified organism (gmo) regulatory framework, to make risk assessment and decision-making more consistent with scientific principles, and to lay the groundwork for international coherence.We discussed the scope and definitions in a previous article and, thus, here we focus on the procedures for risk assessment and risk management.

Journal: Trends in biotechnology (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Membrane extraction with styrene-maleic acid copolymer results in insulin receptor autophosphorylation in the absence of ligand.

Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction.A major advantage of extraction using copolymers rather than detergent is the retention of the lipid bilayer around the proteins.Here we report the first functional investigation of the mammalian insulin receptor which was extracted from cell membranes using poly(styrene-co-maleic acid).We found that the copolymer efficiently extracted the insulin receptor from 3t3l1 fibroblast membranes.Surprisingly, activation of the insulin receptor and proximal downstream signalling was detected upon copolymer extraction even in the absence of insulin stimulation.Insulin receptor and irs1 phosphorylations were above levels measured in the control extracts made with detergents.However, more distal signalling events in the insulin signalling cascade, such as the phosphorylation of akt were not observed.Following copolymer extraction, in vitro addition of insulin had no further effect on insulin receptor or irs1 phosphorylation.Therefore, under our experimental conditions, the insulin receptor is not functionally responsive to insulin.This study is the first to investigate receptor tyrosine kinases extracted from mammalian cells using a styrene-maleic acid copolymer and highlights the importance of thorough functional characterisation when using this method of protein extraction.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Development of Evidence-Based Chinese Medicine Clinical Service Recommendations for Cancer Palliative Care Using Delphi Approach Based on the Evidence to Decision Framework.

S:existing evidence supports the use of certain chinese medicine (cm) interventions for symptom management among palliative cancer patients.However, evidence-based service recommendations tailored to the local context are needed for cm planning and implementation.In response, we aimed to establish consensus on cm clinical service recommendations for cancer palliative care among hong kong experts.methods:seven cm interventions showing statistically significant favorable results in existing systematic reviews (srs) and overviews of srs were subjected to a grade-adolopment-based 2-round delphi survey.Twelve hong kong experts in cancer palliative care, including conventionally trained physicians, cm practitioners, and nurses (n = 4 from each category), were invited to participate.Use of the evidence to decision framework within the grade-adolopment approach enabled experts to consider aspects of problem priority, benefits, harms, equity, acceptability, and feasibility when making cm recommendations in cancer palliative care.results:three evidence-based cm interventions reached positive consensus as service recommendations, namely: (1) acupuncture for reducing fatigue among palliative cancer patients; (2) acupressure for reducing fatigue among palliative cancer patients; and (3) moxibustion for reducing nausea and vomiting among patients receiving chemotherapy.Median rating of recommendation ranged from 2.5 to 3.0 (interquartile range = 0.00-1.00) on a 4-point likert-type scale, and the percentage agreement ranged from 83.4% to 91.7%.conclusions:the grade-adolopment approach facilitates a consensus-based process of reaching 3 evidence-based cm recommendations for cancer palliative care.Future studies may develop tailored strategies to implement these recommendations in the hong kong health system.

Journal: Integrative cancer therapies (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Prognostic Roles of N6-Methyladenosine METTL3 in Different Cancers: A System Review and Meta-Analysis.

Recent studies have shown that methyltransferase-like 3, a catalytic enzyme that is predominant in the n6-methyladenosine methyltransferase system, is abnormally expressed in various types of carcinoma and is correlated with poorer prognosis.However, the clinical functions of methyltransferase-like 3 in the prognosis of tumors are not fully understood.Methods we identified studies by searching pub med, web of science, and med rvix for literature (up to june 30, 2020), and collected a total of 9 studies with 1257 patients for this meta-analysis.The cancer types included gastric cancer, breast cancer, non-small cell lung cancer, bladder cancer, colorectal cancer and ovarian.We further used the cancer genome atlas dataset to validate the results.Results high methyltransferase-like 3 expression clearly predicted a worse outcome (high vs.Low methyltransferase-like 3 expression group; hazard ratio = 2.09, 95% confidence interval 1.53-2.89,p= 0.0001).Moreover, methyltransferase-like 3 expression was associated with differentiation (moderate + poor vs.Well, pooled odds ratio = 1.76, 95% confidence interval 1.32-2.35,p= 0.0001), and gender (male vs.Female, pooled odds ratio = 0.73, 95% confidence interval 0.55-0.97,p= 0.029).Conclusion our results suggest that methyltransferase-like 3 upregulation is significantly associated with poor prognosis and could potentially function as a tumor biomarker in cancer prognosis.

Journal: Cancer control : journal of the Moffitt Cancer Center (2021)
Publication types: Journal Article;Meta-Analysis;Systematic Review
Effects of shading levels on the composition and co-occurrence patterns of bacterioplankton and epibiotic bacterial communities of Cabomba caroliniana.

Epibiotic bacterial community colonized on the plant leaf plays important roles in promoting plant growth and nutrient absorption, but is sensitive to environmental changes.As one of the most important environmental factors affecting the growth of plants and photosynthetic microorganisms, light may affect the diversity, composition, and interactions of the epibiotic bacterial community.Submerged plants in the aquatic ecosystem may be more sensitive to light intensity variations compared to the terrestrial plants since they usually receive less light.However, the effects of light on the interactions between the submerged plants and their epibiotic microbial communities remain uncertain.Here we used the 16s r rna gene high-throughput sequencing to investigate the diversity and composition of the bacterioplankton and epibiotic bacterial communities of the cabomba caroliniana under four different shading levels.A total of 24 water and leaf samples were collected from the experimental microcosms near lake taihu.We found the epibiotic bacterial community possessed a higher diversity than that of the bacterioplankton community, although the alpha diversity of the bacterioplankton community was more susceptible to different levels of shading.Source tracker analysis revealed that with the increase of shading, the colonization of bacterioplankton to epibiotic bacteria decreased.Network analysis showed that the bacterial community network at 50% shading level had the lowest modularity and highest clustering coefficient compared to the bacterial community networks of other shading levels.Our findings provided new understandings of the effects of different light intensities on the epibiotic bacterial communities of submerged macrophytes.

Journal: The Science of the total environment (2021)
Publication types: Journal Article
How Do Employers Belonging to Marginalized Communities Respond to Minimum Wage Increases? The Case of Immigrant-Owned Businesses in Seattle.

Minimum wage opponents often argue that businesses owned by marginalized communities, which include woman-owned, black-owned, and immigrant-owned businesses, are exceptionally vulnerable to minimum wage increases.Little research has investigated this claim.Using a unique survey of seattle businesses that includes owners' nativity status and was administered while the city began to phase in its $15 minimum wage ordinance, the authors find that immigrant-owned businesses respond to the higher minimum wage in ways that largely conform to the responses of other businesses.Nevertheless, immigrant-ownedfranchisesare less likely than other franchises to fire employees, reduce employees' hours, or lower the wages of employees earning more than $15 per hour.Evidence suggests that immigrant franchisees have a lower likelihood of passing the increased labor costs onto employees because they use fewer employees and rely more heavily on family labor compared to other franchisees.The authors' findings suggest that firms owned by marginalized and nonmarginalized groups respond to municipal-level minimum wage increases in comparable ways.Nevertheless, marginalized status may matter more in certain sectors of the economy than in others.

Journal: Economic development quarterly (2022)
Publication types: Journal Article
Relevance of Fatty Acids to Sperm Maturation and Quality.

Almost 50% of infertility cases are associated with human male infertility.The sperm membrane is a key structure influencing sperm morphology and function in normal and pathological conditions.The fatty acid profile determines the performance not only of sperm motility but also of acrosomal reaction and sperm-oocyte fusion.This review presents available knowledge on the role of fatty acid composition in human sperm and spermatogenesis and discusses the influence of dietary fatty acids on the sperm fatty acid profile.Recent studies in biological sciences and clinical researches in this field are also reported.The topic object of this review has potential application in medicine by identifying potential causes of infertility.

Journal: Oxidative medicine and cellular longevity (2020)
Publication types: Journal Article;Review
Adipocyte Plasma Membrane Protein (APMAP) promotes JC Virus (JCPyV) infection in human glial cells.

The demyelinating disease progressive multifocal leukoencephalopathy (pml) is caused by the human polyomavirus, jcpy v, under conditions of prolonged immunosuppression.Initial infection is asymptomatic, and the virus establishes lifelong persistence in the host.Following the loss of immune surveillance, the virus can traffic to the central nervous system and infect oligodendrocytes to cause demyelination and pml.The mechanisms involved in glial cell infection are not completely understood.In a screen for n-glycosylated proteins that influence jcpy v pathology, we identified adipocyte plasma membrane associated protein (apmap) as a host cell modulator of jcpy v infection.The removal of apmap by small interfering si rna as well as by crispr-cas9 gene editing resulted in a significant decrease in jcpy v infection.Exogenous expression of apmap in apmap knockout cell lines rescued susceptibility to infection.These data suggest that virus infection of glial cells is dependent on apmap.

Journal: Virology (2020)
Publication types: Journal Article;Research Support, N.I.H., Extramural
The utility of the emBODY tool as a novel method of studying complex phenomena-related emotions.

Bodily sensations are one of the major building blocks of emotional experience.However, people differ in their ability to recognise and name their emotions, especially those in response to complex phenomena such as climate change or the covid-19 pandemic.Therefore, we investigated whether the bodily sensation maps (bsms) approach can be employed to study emotions related to phenomena that are likely to evoke various, and perhaps even conflicting, emotions in people.Using a unique topographical self-report method-the previously established em body tool, 548 participants marked where in the body they feel sensations (activations and deactivations) when they experience distinct emotions (e.g.Happiness) and when they think about different phenomena, namely climate change, covid-19 pandemic, war, nature, friends, and summer holidays.We revealed maps of bodily sensations associated with different emotions and phenomena.Importantly, each phenomenon was related to a statistically unique bsm, suggesting that participants were able to differentiate between feelings associated with distinct phenomena.Yet, we also found that bsms of phenomena showed some similarity with maps of emotions.Together, these findings indicate that the em body tool might be useful in uncovering the range of emotions individuals experience towards complex phenomena.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't