syedzayyan/paper_mill_benchmark huggingface dataset:
Emphysematous Pyelonephritis in a Diabetic Patient with Remarkable Radiological Findings and Excellent Outcome without Surgical Intervention or Drainage.

Emphysematous pyelonephritis (epn) is a life-threatening infection of the renal parenchyma.The purpose of this report is to present a case of epn with distinctive imaging.Case report an 87-year-old man with a history of type 2 diabetes mellitus presented to the er with fever and shivering, hypotension, and anuria, which is a clinical presentation of septic shock.He had recently been hospitalized at another hospital due to myocardial infarction and ischemic stroke, where a temporary urinary catheter was placed.Upon physical examination, he had right lateral abdominal pain with extension to the right renal region.Laboratory studies showed leucocytosis (wbc: 24 320/μl with 94.4% polymorphonuclear), elevated c-reactive protein 340 mg/l (nv <3.45), and acute renal failure (urea 155mg/dl nv <50 mg/dl, creatinine 4.4 mg/dl nv <1.2 mg/dl).A plain x-ray showed air was present peripheral to the right kidney, while the abdominal ct revealed air inside the right kidney and bilateral nephrolithiasis.The patient was initially put on aggressive hydration, vasoconstrictors, and hydrocortisone to treat the septic shock, and an advanced antibiotic treatment (meropenem) was initiated immediately.Blood culture grew escherichia coli.After 3 days of treatment, he showed significant improvement in diuresis and renal function (urea 90 mg/dl, creatinine 1.0 mg/dl), with a concomitant decrease in inflammatory markers (crp 36.7 mg/l).The antibiotic treatment was tapered to cefuroxime and metronidazole.The patient's condition improved, and he was discharged with per os antibiotic treatment.Subsequently, surgical assessment for the nephrolithiasis was suggested.Conclusions emphysematous pyelonephritis, although rare, should be included in the differential diagnosis of fever in a diabetic patient with renal pain.

Journal: The American journal of case reports (2020)
Publication types: Case Reports;Journal Article
Sex hormones and macronutrient metabolism.

The biological differences between males and females are determined by a different set of genes and by a different reactivity to environmental stimuli, including the diet, in general.These differences are further emphasized and driven by the exposure to a different hormone flux throughout the life.These differences have not been taken into appropriate consideration by the scientific community.Nutritional sciences are not immune from this "bias" and when nutritional needs are concerned, females are considered only when pregnant, lactating or when their hormonal profile is returning back to "normal," i.e., to the male-like profile.The authors highlight some of the most evident differences in aspects of biology that are associated with nutrition.This review presents and describes available data addressing differences and similarities of the "reference man" vs.The "reference woman" in term of metabolic activity and nutritional needs.According to this assumption, available evidences of sex-associated differences of specific biochemical pathways involved in substrate metabolism are reported and discussed.The modulation by sexual hormones affecting glucose, amino acid and protein metabolism and the metabolization of nutritional fats and the distribution of fat depots, is considered targeting a tentative starting up background for a gender concerned nutritional science.

Journal: Critical reviews in food science and nutrition (2015)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Direct fabrication of high-quality vertical graphene nanowalls on arbitrary substrates without catalysts for tidal power generation.

The non-catalytic preparation of high-quality vertical graphene nanowalls (vgn) and graphene-based high output power hydrovoltaic effect power generation devices has always been difficult to achieve.In this work, we successfully prepared vgn with defect density, few layers and submicron domain size on a variety of substrates without catalysts through reasonable adjustment of growth conditions by the hot-wire chemical vapor deposition (hwcvd) method.The raman test of the vgn prepared under optimal conditions showed that its id/igvalue was less than 1, and i2d/igwas more than 2.8.The deposition pressure was a key factor affecting the crystallization quality of the vgn.A suitable deposition pressure of 500 pa could screen the active carbon clusters involved in the growth of nanowalls.The vgn prepared had excellent electrical properties and output of dropping-ion-droplet nano-power generation devices.Because of the larger crystal domain area and smaller contact angle of the vgn, the maximum output power exhibited at 100 pa was 15.7 μw, which exceeded the value produced by other reported hydrovoltaic energy harvesting devices.All of them confirmed that vgn with improved quality had high application prospects in nano-energy devices.

Journal: Nanoscale (2022)
Publication types: Journal Article
Validation of the HPV Impact Profile in Portuguese women with human papilloma virus.

Human papilloma virus (hpv) is the world's most common causative agent in sexually transmitted viral infections; thus requiring clinical guidance, before and after treatment, to promote better quality of life in women diagnosed with hpv.The hpv impact profile (hip) is a comprehensive instrument used to assess the psychosocial impact of hpv and related interventions in a wide range of domains.The main purpose of this study was to validate the hip in portuguese women, so that it can be used in this population, both in research and in clinical settings.methods:a sample of 178 portuguese women infected with hpv were assessed with the following instruments: index of sexual satisfaction, hospital anxiety and depression scale and hpv impact profile.results:the results of the confirmatory factor analysis showed some changes to the original model, which resulted in an adapted version with six domains, compared to the seven domains of the original model.The final model showed a good fit to the data.All cronbach's alphas were higher than 0.79 indicating a high level of internal consistency of the subscales.As in the original hip questionnaire, the exception was sexual impact, with a lower, but acceptable, cronbach's alpha.Convergent and discriminant validities of the instrument were also assessed.conclusions:the portuguese version of the hip presents good psychometric properties, allowing its use in clinical trials as well as in clinical practice in order to evaluate quality of life in women with hpv.

Journal: Current medical research and opinion (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Validation Study
Bioactive glass, a new tool for the treatment in the diabetic foot recalcitrant osteomyelitis: A case series with 24-month follow-up.

The bioactive glass (bag) is a promising solution for the reconstruction of bone defects and the eradication of infection in patients with osteomyelitis, however references to the treatment of diabetic foot osteomyelitis are scarce in the literature.Methods our experience in patients with diabetic foot osteomyelitis, who required surgical debridement and void filling, in which we use bioactive glass (n = 6), was evaluated.During a minimum follow-up of 24 months, the presence of persistent infection and healing rate, post-surgical complications, surgical reinterventions, degree of osseointegration and bag-related side effects was analyzed.Results at the end of the follow-up, none of the patients showed signs of persistent infection and the healing rate was 66.6% (4/6).Postoperative complications were noted in 3 patients and two of the them required new surgical intervention, both due to skin coverage or vascular complications.A complete osseointegration in the 66.6% of the patients and no cases of local adverse effects were recorded.Conclusions the bioactive glass can be a useful tool in the treatment of certain cases of diabetic foot osteomyelitis, provided that a multidisciplinary approach and strict patient selection is in place.Level of evidence iv.

Journal: Foot (Edinburgh, Scotland) (2021)
Publication types: Journal Article
Open or closed: Changes in ductus arteriosus flow patterns at birth using 4D flow MRI in newborn piglets.

The ductus arteriosus (da) functionally closes during the transition from fetal to postnatal life because of lung aeration and corresponding cardiovascular changes.The thorough and explicit measurement and visualization of the right and left heart output during this transition has not been previously accomplished.We combined 4d flow mri (dynamic volumetric blood flow measurements) and t2 relaxometry (oxygen delivery quantification) in surgically instrumented newborn piglets to assess the da.This was performed in large white-landrace-duroc piglets (n = 34) spanning four age groups: term-9 days, term-3, term+1, and term+5.Subject's da status was classified using 4d flow: closed da, forward da flow, reversed da flow, and bidirectional da flow.Over all states, vessel diameters and flows normalized to body weight increased with age (for example in the ascending aorta flow-term-9: 126.6 ± 45.4; term+5: 260.2 ± 80.0 ml/min per kg; p = 0.0005; ascending aorta diameter-term-9: 5.2 ± 0.8; term+5: 7.7 ± 0.4 mm; p = 0.0004).In subjects with reversed da blood flow there was lower common carotid artery blood flow (forward: 37.5 ± 9.0; reversed: 20.0 ± 7.4 ml/min per kg; p = 0.032).Linear regression revealed that as net da flow decreases, common carotid artery flow decreases (r2= 0.32, p = 0.004), and left (r2= 0.33, p = 0.003) and right (r2= 0.34, p = 0.003) pulmonary artery flow increases.Bidirectional da blood flow changed oxygen saturation as determined by mri between the ascending and descending aorta (ascending aorta: 90.1% ± 8.4%; descending aorta: 75.6% ± 14.2%; p < 0.05).Expanded use of these techniques in preterm animal models will aid in providing new understandings of normal versus abnormal da transition, as well as to test the effectiveness of related clinical interventions.

Journal: Physiological reports (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Epidemiology of Cardiopulmonary Arrest and Outcome of Resuscitation in PICU Across China: A Prospective Multicenter Cohort Study.

To investigate the epidemiology and the effectiveness of resuscitation from cardiopulmonary arrest (cpa) among critically ill children and adolescents during pediatric intensive care unit (picu) stay across china.Methods a prospective multicenter study was conducted in 11 picus in tertiary hospitals.Consecutively hospitalized critically ill children, from 29-day old to 18-year old, who had suffered from cpa and required cardiopulmonary resuscitation (cpr) in the picu were enrolled (december 2017-october 2018).Data were collected and analyzed using the "in-hospital utstein style." neurological outcome was assessed with the pediatric cerebral performance category (pcpc) scale among children who had survived.Factors associated with the return of spontaneous circulation (rosc) and survival at discharge were evaluated using multivariate logistic regression.Results among 11,599 admissions to picu, 372 children (3.2%) had cpa during their stay; 281 (75.5%) received cpr, and 91 (24.5%) did not (due to an order of "do not resuscitate" requested by their guardians).Cardiopulmonary disease was the most common reason for cpa (28.1% respiratory and 19.6% circulatory).The most frequent initial dysrhythmia was bradycardia (79%).In total, 170 (60.3%) of the total children had an rosc, 91 had (37.4%) survived till hospital discharge, 28 (11.5%) had survived 6 months, and 19 (7.8%) had survived for 1 year after discharge.Among the 91 children who were viable at discharge, 47.2% (43/91) received a good pcpc score (1-3).The regression analysis results revealed that the duration of cpr and the dose of epinephrine were significantly associated with rosc, while the duration of cpr, number of cpr attempts, ventricular tachycardia/ventricular fibrillation (vt/vf), and the dose of epinephrine were significantly associated with survival at discharge.Conclusion the prevalence of cpa in critically ill children and adolescents is relatively high in china.The duration of cpr and the dose of epinephrine are associated with rosc.The long-term prognosis of children who had survived after cpr needs further improvement.

Journal: Frontiers in pediatrics (2022)
Publication types: Journal Article
RNA Editing in Glioma as a Sexually Dimorphic Prognostic Factor That Affects mRNA Abundance in Fatty Acid Metabolism and Inflammation Pathways.

Rna editing alters the nucleotide sequence and has been associated with cancer progression.However, little is known about its prognostic and regulatory roles in glioma, one of the most common types of primary brain tumors.We characterized and analyzed rna editomes of glioblastoma and isocitrate dehydrogenase mutated (idh-mut) gliomas from the cancer genome atlas and the chinese glioma genome atlas (cgga).We showed that editing change during glioma progression was another layer of molecular alterations and that editing profiles predicted the prognosis of glioblastoma and idh-mut gliomas in a sex-dependent manner.Hyper-editing was associated with poor survival in females but better survival in males.Moreover, noncoding editing events impacted m rna abundance of the host genes.Genes associated with inflammatory response (e.g.,eif2ak2, a key mediator of innate immunity) and fatty acid oxidation (e.g.,acyl-co a oxidase 1, the rate-limiting enzyme in fatty acid β-oxidation) were editing-regulated and associated with glioma progression.The above findings were further validated in cgga samples.Establishment of the prognostic and regulatory roles of rna editing in glioma holds promise for developing editing-based therapeutic strategies against glioma progression.Furthermore, sexual dimorphism at the epitranscriptional level highlights the importance of developing sex-specific treatments for glioma.

Journal: Cells (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Physiological reactivity in children with high callous-unemotional and autistic traits: investigating unique and interactive effects.

Empathy deficits are a hallmark sign of both callous-unemotional (cu) and autistic traits.Despite these similarities, prior work did not investigate how these traits relate to physiological reactivity (heart rate and skin conductance) in response to emotional or empathy-eliciting stimuli.Understanding the physiological mechanisms associated with emotional processing deficits among individuals with autistic or cu traits is a critical step for improving both assessment and interventions.The current study was designed to investigate the unique and interactive contributions of cu and autistic traits in predicting physiological reactivity.Heart rate (hr) and skin conductance (sc) activity in response to sad, fearful and happy emotional videos were collected form young children.Participants for the current study (n = 163; mage= 7.30, sd= 1.42; 44.2% girls) were recruited from a larger community sample of 1652 children and were selected based on their levels of empathy.Regression analysis revealed that boys, but not girls, with high levels of cu traits exhibited low sc reactivity during sad and fearful stimuli.No significant associations were revealed for autistic traits.Finally, an interesting interaction effect suggested that cu traits were associated with stronger hr reactivity to fear stimuli only when autistic traits were low.The identified differences in physiological reactivity can inform etiological hypothesis by providing evidence for the underlying physiological mechanisms related to emotional processing among children high in cu traits but not in autistic traits.

Journal: European child & adolescent psychiatry (2021)
Publication types: Journal Article
Clinical and Echocardiographic Outcomes of Transcatheter Tricuspid Valve Interventions: A Systematic Review and Meta-Analysis.

Medically managed tricuspid regurgitation (tr) has detrimental outcomes.Transcatheter tricuspid valve interventions (ttvis) represent an alternative to surgery in high-risk patients; however, only early experiences exist.Aim the aim of this study was to analyze the clinical and echocardiographic outcomes of ttvi.Methods medline, isi web of science, and scopus databases were searched for studies published up to june 2021.Studies reporting data on outcome post-ttvis were included.This study was designed according to preferred reporting items for systematic reviews and meta-analyses (prisma) requirements.The primary endpoint was all-cause mortality at 30-day and 1-year post-ttvi.Results out of 2,718 studies, 27 were included.Notably, 30-day and 1-year all-cause mortalities were 5% (95% confidence interval [ci]: 4-8%,p< 0.001) and 25% (95% ci: 12-45%,p= 0.016).Procedural success was associated with a 58% risk reduction in 1-year mortality vs.Lack thereof (odds ratio 0.42, 95% ci: 0.27-0.66,p< 0.001).Ttvi is associated with a significant reduction in tr severity (tr eroa, mean difference [md] 0.31 cm2; 95% ci: 0.23-0.39 cm2,p< 0.001; regurgitant volume, md 23.54 ml; 95% ci: 17.4-29.68 ml,p= 0.03) and increase in forward stroke volume (fsv, md 3.98 ml; 95% ci: 0.11-7.86 ml,p= 0.04).Conclusion ttvi significantly reduces tr severity and increases fsv and is associated with improved survival at 1 year compared with patients without procedural success.Long-term outcomes compared with medical therapy await the results of ongoing pivotal trials; nonetheless, ttvis appear to be a promising alternative to surgery for tr.

Journal: Frontiers in cardiovascular medicine (2022)
Publication types: Systematic Review;Journal Article
Knockdown of Helicoverpa armigera protease genes affects its growth and mortality via RNA interference.

Helicoverpa armigera (hübner) (lepidoptera: noctuidae), the cotton bollworm, is a destructive pest which is famous for its resistance to a variety of insecticides.Rna interference is a posttranscriptional gene silencing mechanism that has become a popular tool to control insect pests, triggered by double-stranded rnas (ds rnas).The effect of ingestion and injection delivery methods of ds rna related to some protease genes including trypsin (ha-try39 and ha-try96), chymotrypsin (ha-chy), and cathepsin l (ha-cat) on growth and development of h.Armigera was investigated in this study.All protease genes encoded full orfs and were expressed in all h.Armigera larvae stages and tissues.In both injection and feeding bioassays, ha-rnai chy's performance outperformed that of other protease genes.Chy enzyme activity in the midgut of larvae was significantly reduced after treatment with ds-ha chy.Oral administration of ds-chy also resulted in significant mortality of h.Armigera larvae.However, because of the high rnase activity in the midgut lumen of lepidoptera, a large amount of ds rna was needed to effectively kill instars of h.Armigera.To reduce ds rna degradation, bacterial expression and ds rna formulation were used.After oral administration, it was toxic to h.Armigera larvae.Before oral administration, bacterial cells were sonicated to increase ds rna release.The rna interference efficiency of sonicated bacteria was significantly increased, resulting in higher larval mortality when administered orally.All of these findings point to ha-chy as a new candidate for developing an effective ds rna-based pesticide for h.Armigera control.

Journal: Archives of insect biochemistry and physiology (2021)
Publication types: Journal Article
TRAF2/ASK1/JNK Signaling Pathway Is Involved in the Lung Apoptosis of Swine Induced by Cadmium Exposure.

Cadmium (cd), a toxic heavy metal, exists widely in the environment, which can enter organisms through a variety of ways and cause damage to various organs and tissues.However, the mechanism of lung toxicity in swine after cd exposure is still unclear.To explore the molecular mechanism of swine lung damage caused by cd exposure, we established the model of cd exposure, and cd chloride (20 mg/kg cd cl2) was added to the diet of swine for continuous exposure for 40 days.Tunel staining showed that the apoptosis of swine lung increased significantly after cd exposure.Meanwhile, the results of q rt-pcr showed that cd induced oxidative stress and inhibited the expression of antioxidant enzymes including cat, gclm, gst, sod, and gsh-px in lung tissue.Cd exposure activated mitochondrial apoptosis pathway via the traf2/ask1/jnk signaling pathway.In brief, we considered that cd exposure causes oxidative stress in lung and induces lung cell apoptosis through the traf2/ask1/jnk pathway and increases the expression of hsps to resist the toxicity of cd.Our research enriches the theoretical basis of cd toxicity and provides reference for comparative medicine.

Journal: Biological trace element research (2022)
Publication types: Journal Article
Anatomic Approach and Outcomes in Children Undergoing Percutaneous Pericardiocentesis.

Pericardiocentesis is traditionally performed using a subxiphoid approach.Hepatomegaly or loculated and noncircumferential effusions warrant nonstandard approaches to drain effusions; echocardiographic guidance has made these less traditional, non-subxiphoid approaches feasible.The study is aimed at comparing clinical outcomes of the subxiphoid and non-subxiphoid approaches to percutaneous pericardiocentesis in a pediatric population.This is a retrospective chart review of all children undergoing percutaneous pericardiocentesis from august 2008 to december 2019 at a single-center.A total of 104 patients underwent echocardiography-guided pericardiocentesis during the timeframe.Additionally, fluoroscopy was also used in 80 patients.Hematopoietic stem cell transplantation was the most common underlying diagnosis (n = 53, 50.9%).A non-subxiphoid approach was used in 58.6% (n = 61) of patients.The fifth and sixth intercostal spaces were the most commonly used (n = 17 each).The non-subxiphoid group tended to be older (95.9 vs.21.7 months, p = 0.006) and weighed more (23.6 vs.11.2 kgs, p = 0.013) as compared to the subxiphoid group.Non-subxiphoid approach was associated with shorter procedure times (21 vs.37 min, p = 0.005).No major complications were seen.Five minor complications occurred and were equally distributed in the two groups.Complications were more likely in younger patients (p = 0.047).The technique and anatomic approach to pericardiocentesis, and the location or size of effusion did not influence the risk of complications.Echocardiography-guided percutaneous pericardiocentesis in children was associated with low complication rates in this single-center pediatric experience.The use of a non-traditional, non-subxiphoid approach was associated with shorter procedure times and did not significantly affect complication rates.

Journal: Pediatric cardiology (2021)
Publication types: Journal Article