syedzayyan/paper_mill_benchmark huggingface dataset:
Insights into the behavioural responses of juvenile thornback ray Raja clavata to alternating and direct current magnetic fields.

As part of energy transition, marine renewable energy devices (mred) are currently expanding in developed countries inducing the deployment of dense networks of submarine power cables.Concern has thus raised about the cable magnetic emissions (direct or alternating current) because of potential interference with the sensorial environment of magneto-sensitive species, such as sharks and rays.This study sought to assess the short-term behavioural responses of juvenile thornback rays (raja clavata) (n = 15) to direct and alternating (50 hz) uniform 450-μt artificial magnetic fields using 1 h focal-sampling design based on a detailed ethogram.Careful control of magnetic fields' temporal and spatial scales was obtained in laboratory conditions through a custom-made helmholtz coil device.Overall, qualitative or quantitative behavioural responses of juvenile rays did not significantly vary between control vs.Exposed individuals over the morning period.Nonetheless, rays under direct current magnetic field increased their activity over the midday period.Synchronisation patterns were also observed for individuals receiving alternating current exposure (chronologic and qualitative similarities) coupled with a high inter-individual variance.Further studies should consider larger batches of juveniles to address the effect of long-term exposure and explore the sensitivity range of rays with dose-response designs.

Journal: Journal of fish biology (2022)
Publication types: Journal Article
Speaking of State of Mind: Maternal Mental Health Predicts Children's Home Language Environment and Expressive Language.

Maternal depression and anxiety are potential risk factors to children's language environments and development.Though existing work has examined relations between these constructs, further work is needed accounting for both depression and anxiety and using more direct measures of the home language environment and children's language development.We examined 265 mother-infant dyads (49.6% female, mage = 17.03 months) from a large city in the western united states to explore the relations between self-reports of maternal depression and anxiety and observational indices of the home language environment and expressive language as captured by language environment analysis (lena) and parent-reported language comprehension and production.Results revealed maternal depressive symptoms to be negatively associated with home language environment and expressive language indices.Maternal anxiety symptoms were found to be negatively associated with children's parent-reported language production.These findings provide further evidence that maternal mental health modulates children's home language environments and expressive language.

Journal: Journal of child language (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Precancerous Cervical Lesions Among HIV-Infected Women Attending HIV Care and Treatment Clinics in Southwest Ethiopia: A Cross-Sectional Study.

Despite being one of the few cancers that can be prevented with simple testing, cervical cancer is the fourth most common cancer in women.Hiv-positive women showed a median three-fold higher incidence of cervical lesions.Aim this study aims to assess the prevalence and factors associated with precancerous cervical lesions among hiv-infected women attending care and treatment clinic in selected hospitals of southwestern ethiopia.Methods institution-based cross-sectional study was conducted from february 1 to july 30, 2018.A systematic random sampling technique was employed to select 454 hiv-infected women.Pretested interviewer-administered questionnaire and medical record review were used for data collection.Visual inspection with acetic acid was done for participants to detect precancerous cervical lesions.Data were analyzed by spss version 20.Binary and multiple logistic regression analyses were done.The presence and strength of association were determined using aor with its 95% ci.Variables with a p value of less than 0.05 were considered as statistically significant.Results the prevalence of precancerous cervical lesion was 18.7% [95% ci; (15.1-22.4%)].Currently, not being on highly active antiretroviral treatment [aor= 2.31, 95% ci: 1.23-4.39], age (20-29 years) [aor= 0.185, 95% ci: 0.036,0.939], has no history of sexually transmitted infection [aor=0.026, 95% ci: 0.006-0.116], has no history of genital wart [aor= 0.261, 95% ci: 0.073-0.934] and having one lifetime sexual partner [aor=0.133, 95% ci: 0.024-0.726] were found to be significantly associated with precancerous cervical lesion.Conclusion the prevalence of precancerous cervical lesion was found to be high in this study.Expansion of screening services and undertaking preventive measures against sexually transmitted infection need to be emphasized.

Journal: International journal of women's health (2021)
Publication types: Journal Article
CRISPR/Cas12a-Derived electrochemical aptasensor for ultrasensitive detection of COVID-19 nucleocapsid protein.

Fast, affordable, portable, and sensitive technology to detect covid-19 is critical to address the current outbreak.Here, we present a crispr/cas12a-derived electrochemical aptasensor for cost-effective, fast, and ultrasensitive covid-19 nucleocapsid protein (np) detection.First, an electrochemical sensing interface was fabricated by immobilizing methylene blue labeled poly adenines dna sequence (poly a-mb electrochemical reporter) on a gold electrode surface.Second, an arched probe was prepared via hybridization of np aptamer and an activator strand.In the presence of covid-19 np, the activator strand could be released from the arched probe due to the specific interaction between the target and the aptamer, which then activated the trans-cleavage activity of the crispr/cas12a system.Subsequently, the poly a-mb reporters were cleaved from the electrode surface, decreasing the current of differential pulse voltammetry (dpv) at a potential of -0.27 v(vs.Ag/ag cl).The crispr/cas12a-derived electrochemical aptasensor shows a highly efficient performance for covid-19 np detection in 50 pg m l-1to 100 ng m l-1with a limit of detection (lod) low to 16.5 pg m l-1.Notably, the whole process of one test can be completed within 30 min.Simultaneously, the aptasensor displays a high selectivity to other proteins.The further measurements demonstrate that the aptasensor is robust in a natural system for point-of-care testing, such as in tap water, milk, or serum.The aptasensor is universal and expandable and holds great potential in the covid-19 early diagnosis, environmental surveillance, food security, and other aspects.

Journal: Biosensors & bioelectronics (2022)
Publication types: Journal Article
Origin and Phylogeography of Chinese Cereal Cyst NematodeHeterodera avenaeRevealed by Mitochondrial COI Sequences.

Heterodera avenae, a globally distributed plant-parasitic nematode, is one of the most significant pests on cereal crops.In china, it is widely distributed in cereal-growing areas of 16 provinces and causes serious yield losses.In the present study, a total of 98 populations of h.Avenaewere collected from major wheat-growing regions in china and six other countries.The mitochondrial coi genes were amplified and analyzed.Forty-one mitochondrial coi haplotypes were identified, suggesting a high genetic diversity and endemism level of h.Avenaein china.Phylogenetic analysis showed that h.Avenaepopulations in china were divided into four clades.Significant evolutionary and genetic differences were found between chinese (except hubei) and foreign populations.Hap1, the most widely distributed haplotype, was considered to be a separate evolutionary origin in china.The gene flow of h.Avenaefrom the northwestern region to the north china region and huang-huai-hai region was significant, so as the direction between north china and huang-huai-hai region.We speculate that water flowing from the yellow river and mechanical harvesters promoted gene exchange among these groups.A distance-based redundancy analysis showed that genetic distances observed among h.Avenaepopulations were explained foremost not only by geographic distance but also by temperature and precipitation.This study provides theoretical support for the origin and spread of h.Avenaepopulations in china and elsewhere in the world.

Journal: Phytopathology (2022)
Publication types: Journal Article
Ligand Substitution and Electronic Structure Studies of Bis(phosphine)Cobalt Cyclooctadiene Precatalysts for Alkene Hydrogenation.

Diene self-exchange reactions of the 17-electron, formally cobalt(0) cyclooctadienyl precatalyst, (r,r)-(i pr du phos)co(cod) (p2co cod, (r,r)-i pr du phos = 1,2-bis((2r,5r)-2,5-diisopropylphospholano)benzene, cod = 1,5-cyclooctadiene) were studied using natural abundance and deuterated 1,5-cyclooctadiene.Exchange of free and coordinated diene was observed at ambient temperature in benzene-d6solution and kinetic studies support a dissociative process.Both neutral p2co codand the 16-electron, cationic cobalt(i) complex, [(r,r)-(i pr du phos)co(cod)][bar f4] (bar f4= b[(3,5-(cf3)2)c6h3]4) underwent instantaneous displacement of the 1,5-cyclooctadiene ligand by carbon monoxide and generated the corresponding carbonyl derivatives.The solid-state parameters, dft-computed mulliken spin density and analysis of molecular orbitals suggest an alternative description of p2co codas low-spin cobalt(ii) with the 1,5-cyclooctadiene acting as a lx2-type ligand.This view of the electronic structure provides insight into the nature of the ligand substitution processes and the remarkable stability of the neutral cobalt complexes toward protic solvents observed during catalytic alkene hydrogenation.

Journal: Canadian journal of chemistry (2021)
Publication types: Journal Article
The use of social media inside and outside the classroom to enhance students' engagement in EFL contexts.

It could be claimed that without any doubt the internet has revolutionized the educational system to a great extent.Even though some are still interested in traditional ways of teaching and learning and also face-to-face classes, technological advances, in particular, social media have changed the english as a foreign language (efl) contexts in a way that they will not be compatible with any other methods that have long been utilized before.Despite the fact that some studies have been conducted in different learning contexts, to the researcher's best knowledge, attention has not been focused on the importance of social media inside and outside the classroom on efl students' indulgence.Therefore, the aim of this review is to synthesize the findings of the previous studies to highlight the role of social media in efl students' engagement throughout class and outside the class in both face-to-face and online classes.To reach this goal, this review first discusses the impact of social media on engagement, and then engagement and its classifications are dealt with.Next, the relationship between using social media and students' engagement is discussed.And finally, some implications are proposed.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article;Review
Mediational Effect of Fairburn's Transdiagnostic Mechanisms Between Attachment to the Mother and Eating Disorder Symptoms in a Clinical Sample.

Research has supported a link between insecure attachment and eating disorders (eds); however, little is known about how this influence is exerted in young female eds patients.This study tested, for the first time, a multiple mediational model, wherein the four fairburn's transdiagnostic mechanisms mediated the relationship between attachment to the mother and ed symptoms.Methods a total of 101 female young eds patients aged 15-24 were administered the inventory of parent and peer attachment, eating disorder inventory-3 and eating attitudes test-26 to assess attachment, the four transdiagnostic maintaining mechanisms and ed symptoms, respectively.Results comparison analyses showed that there were no significant differences between the diagnostic groups in terms of attachment and the transdiagnostic variables.Multiple mediational analyses indicated that low self-esteem and clinical perfectionism were significant mediators between insecure attachment to the mother and ed symptoms, while controlling for depressive symptoms.Conclusion these findings suggest that the distal risk influence of insecure attachment to the mother in the development of ed symptoms might be explained by low self-esteem and high clinical perfectionism, controlling for depressive symptoms.Further investigation into the efficacy of cognitive-behavioral treatments targeting insecure attachment representations for young eds patients is recommended.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article
Digestive properties and prebiotic activity of garlic saccharides with different-molecular-weight obtained by acidolysis.

Garlic saccharides have prebiotic activity, but the association between their function and structure is still poorly known.In present study, four different garlic saccharides were obtained from garlic polysaccharides (gps) after acidolysis by ultrafiltration.Obtained gps were constituted by different monosaccharides, among which fructose and glucose were the main components, while galactose was a major component of gps-u6.All four saccharides were partly degraded by the simulated digestive system, and most could reach the large intestine to be utilized by the gut microbiota.Except for gps-u6, the other three garlic saccharide fractions had good prebiotic activityin vitroandin vivo.Furthermore, gps-u0.3 with lower molecular weight (mw) showed better prebiotic activity, including promoting the production of short-chain fatty acids (scfas), increasing the abundance of beneficial bacteria such as bifidobacterium,lachnospiraceae nk4a136group and phoscolarctobacterium, and inhibiting the growth of potentially harmful bacteria.In addition, kyoto encyclopedia of genes and genomes (kegg) pathway enrichment analysis showed that gps-u0.3 could reduce the risk of cancer and cardiovascular diseases.Overall, this findings of the present study revealed the digestive properties of gps, as well as the potential association between their chemical structures and fermentation characteristics by gut microbiota.Thus, it can be stated that gps-u0.3 can be used as potential prebiotics in functional foods, which provides a theoretical basis for the targeted preparation of functionalized garlic saccharides.

Journal: Current research in food science (2022)
Publication types: Journal Article
Interprofessional peer teaching: The value of a pharmacy student-led pharmacology course for physical therapy students.

This report describes the creation, implementation, and evaluation of an interprofessional pharmacy student-led pharmacology course for physical therapy students.The course was designed using a flipped classroom model and a peer-assisted learning framework.Interprofessional education activity we describe the development, design, assessment, and evaluation of a pharmacy student-led pharmacology course for physical therapy students.This report focuses specifically on the interprofessional aspect of the course, which was measured using the student perceptions of physician-pharmacist interprofessional clinical education (spice) instrument.Discussion the spice instrument was measured across two cohorts in 2015 and 2016.Each cohort consisted of approximately 50 physical therapy students.After implementation of the course, there were significant improvements across all three domains of the spice instrument: interprofessional teamwork, roles/responsibilities for collaborative practice, and patient outcomes from collaborative practice (p < .01).Qualitative feedback from the physical therapy students and pharmacy student teaching assistants was positive and emphasized the benefits of interprofessional peer teaching.Implications overall, this interprofessional peer teaching model effectively improved interprofessional attitudes while accomplishing didactic needs.This innovative course may serve as a model for interprofessional education in different subject areas or across other health professions programs.

Journal: Currents in pharmacy teaching & learning (2020)
Publication types: Journal Article
Performance of 3 Sets of Criteria for Potentially Inappropriate Prescribing in Older People to Identify Inadequate Drug Treatment.

Importance potentially inappropriate medications (pims) and potential prescribing omissions (ppos) are used in research to reflect the quality of drug treatment in older people and have been suggested for inclusion in core outcome sets for evaluation of interventions for improved prescribing.Their validation so far, however, is primarily restricted to expert opinion-based processes.Objective to evaluate the performance of 3 explicit pim/ppo criteria sets as diagnostic tools to identify inadequate drug treatment in older patients.Design, setting, and participants this diagnostic study analyzed patients aged 65 years or older consecutively included from 2 primary health care centers from october to november 2017.Data were analyzed from february to august 2022.Exposures the pims/ppos were concordantly identified by 2 specialist physicians (2018-2019) retrospectively after a planned physician visit, using 3 european pim/ppo criteria sets and without knowledge of this diagnostic study.Main outcomes and measures area under the receiver operating characteristic (roc) curve, reflecting the ability of pim/ppo criteria sets to identify the reference standard of inadequate drug treatment, determined by 2 specialist physicians in consensus.Inadequate drug treatment implied that additional action related to the medication could be medically justified before the next regular visit.Results a total of 302 patients were analyzed (median age, 74 [iqr, 69-81] years; 178 women [59%]; median number of drugs in the medication list, 6 [iqr, 3-9]); 98 patients (32%) had inadequate drug treatment.A total of 0 to 8 pims/ppos per patient were identified using the screening tool of older persons' prescriptions (stopp)/screening tool to alert to right treatment (start) criteria, 0 to 6 with the european eu(7)-pim list, and 0 to 12 with the swedish set of indicators of prescribing quality.The areas under the roc curve for the 3 sets to identify the reference standard for inadequate drug treatment were 0.60 (95% ci, 0.53-0.66) for the stopp/start criteria, 0.69 (95% ci, 0.63-0.75) for the eu(7)-pim list, and 0.73 (95% ci, 0.67-0.80) for the swedish set.For comparison, the area under the roc curve was 0.71 (95% ci, 0.65-0.78) using the number of drugs in the medication list.Conclusions and relevance in this diagnostic study, the evaluated pim/ppo sets had poor to fair performance as diagnostic tools to identify inadequate drug treatment, comparable with a simple count of the number of drugs in the medication list.These findings suggest that use of pims/ppos as indicators of drug treatment quality in core outcome sets for the evaluation of interventions for improved prescribing may need reconsideration.

Journal: JAMA network open (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Atmospheric pressure plasma treatment induces abscisic acid production, reduces stomatal aperture and improves seedling growth in Arabidopsis thaliana.

Cold atmospheric pressure plasmas (capps) have been widely used for pre-sowing treatment in agriculture to accelerate seed germination; however, information on their application to pre-transplant seedlings is scarce.The roles of the phytohormone abscisic acid (aba) on guard cell aperture that control air exchange with the environment were investigated after capps treatment.In this study, arabidopsis thaliana seedling growth was evaluated under capps treatment at different doses.Besides, the optimal growth stimulation dose was selected to further evaluate changes in aba, ros, ca2+and stomatal aperture during growth .the expression of most aba signalling genes were aslo examined to investigate the mechanism.Capps treatment for 1 min significantly promoted arabidopsis seedling growth; the aba concentration in seedlings increased and peaked 48 h after treatment but was lower than in the control after 96 h.Transcript levels of most aba signalling genes were markedly enhanced at 48 h, although their transcripts were significantly downregulated after 96 h.Capps treatment also reduced stomatal aperture after 24 h and accelerated ros accumulation in guard cells.The ca2+concentration in the treatment group was markedly higher than in the control at 24 and 96 h.The results suggest that capps treatment accelerates aba accumulation in arabidopsis at early growth stages and aba regulates ros and ca2+concentrations to affect stomatal aperture, and both aba and stoma size are affected in capps stimulation of arabidopsis seedling growth.

Journal: Plant biology (Stuttgart, Germany) (2021)
Publication types: Journal Article
Valproate-Induced Bicytopenia: A Case Study.

This case report describes a 22-year-old male patient diagnosed with schizoaffective disorder.A multidrug regimen including olanzapine and lorazepam was initiated for the patient.Sodium valproate was added to the regimen in due course and it was associated with bicytopenia in the form of thrombocytopenia and leukopenia.Valproate was identified as the offending drug and further doses were withheld.Lithium was used as a substitute to valproate and the patient spontaneously recovered without any further complications.This case report highlights the necessity of periodic investigations and frequent logging of blood indices to counter the threat of fatal adverse drug reactions.

Journal: Cureus (2022)
Publication types: Case Reports;Journal Article
Direct and quantitative analysis of altered metabolic flux distributions and cellular ATP production pathway in fumarate hydratase-diminished cells.

Fumarate hydratase (fh) is an enzyme in the tricarboxylic acid (tca) cycle, biallelic loss-of-function mutations of which are associated with hereditary leiomyomatosis and renal cell cancer.However, how fh defect modulates intracellular metabolic fluxes in human cells has remained unclear.This study aimed to reveal metabolic flux alterations induced by reduced fh activity.We applied13c metabolic flux analysis (13c-mfa) to an established cell line with diminished fh activity (fhdim) and parental hek293 cells.Fhdimcells showed reduced pyruvate import flux into mitochondria and subsequent tca cycle fluxes.Interestingly, the diminished fh activity decreased fh flux only by about 20%, suggesting a very low need for fh to maintain the oxidative tca cycle.Cellular atp production from the tca cycle was dominantly suppressed compared with that from glycolysis in fhdimcells.Consistently, fhdimcells exhibited higher glucose dependence for atp production and higher resistance to an atp synthase inhibitor.In summary, using fhdimcells we demonstrated that fh defect led to suppressed pyruvate import into mitochondria, followed by downregulated tca cycle activity and altered atp production pathway balance from the tca cycle to glycolysis.We confirmed that13c-mfa can provide direct and quantitative information on metabolic alterations induced by fh defect.

Journal: Scientific reports (2020)
Publication types: Journal Article