syedzayyan/paper_mill_benchmark huggingface dataset:
SIX4 activates Akt and promotes tumor angiogenesis.

Angiogenesis plays important roles in solid tumors progression.Growth factors such as vascular endothelial growth factors (vegfs) can induce angiogenesis and hypoxia promotes the expression of vegfs through activating hypoxia-inducible factor 1 (hif-1α).However, the regulation of hif-1α still not been fully understood.Here, we demonstrate that the sine oculis homeobox homolog 4 (six4) is up-regulated in colorectal cancer (crc) and high expression of six4 predicts a poor prognosis.Overexpression of six4 enhances tumor growth and angiogenesis in vitro and in vivo, while knockdown of six4 inhibits tumor growth and angiogenesis.Furthermore, we show that six4 increases the expression of vegf-a by coordinating with the hif-1α.Mechanically, we explore that six4 up-regulates the expression of hif-1α depending on akt activation.Collectively, we demonstrate that six4 is functional in regulating tumor angiogenesis and six4 might be used as anti-angiogenic therapy in crc.

Journal: Experimental cell research (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Enforced Remote Work During COVID-19 and The Importance of Technological Competency: A Job Demands-Resources Perspective.

As we live in the era of technology, it is clear that employees' technical skills and savviness are important to their work performance.With the covid-19 pandemic, these qualities have become a "necessity‿ for many employees as they have switched to remote working.Less attention, however, has been given to empirical evidence regarding how employees' technological competencies influence their work outcomes during a forced shift to remote work.Integrating the theories of job demands-resources and conservation of resources, this study sought to provide evidence regarding the joint effect of job/personal resources and technological competency on levels of employees' remote work engagement and performance.Method a total of 131 teachers working in turkey completed an online survey during the initial months of the covid-19 pandemic.Spss process macro (model 7) was used for hypotheses testing.Results we found partial support for the proposed moderated mediation model.Specifically, psychological resilience (as a personal resource) increased the level of work performance through work engagement and this relationship was stronger among employees with high levels of technological competency.However, the results did not provide support for the hypothesized interaction effect of workplace support (as a job resource) and technological competency on work performance through work engagement.Conclusion this research advances the theoretical and empirical understanding of the role of technological competency in the motivational process of the job demands-resources model.Our findings suggest that providing training activities aimed at promoting employee learning in the domain of online work tools can accelerate the effect of personal resources on work outcomes, especially during enforced remote working, as in the case of covid-19.

Journal: European review of applied psychology = Revue europeenne de psychologie appliquee (2022)
Publication types: Journal Article
Nanomaterials, a New Challenge in the Workplace.

Nanomaterials are a nanotechnological product of increasing importance given the possibilities they offer to improve quality of life and support sustainable development.Safe management of nanomaterials is needed to ensure that this emerging technology has the highest levels of acceptance among different interest groups, including workers.This chapter reviews the current state that presents the different stages of risk management applied to nanomaterials, including standardisation, regulation, risk assessment and risk control.Particularly, the chapter contextualizes the development of nanotechnologies at european level and analyses the scientific evidence available on the risks derived from nanomaterials use.Furthermore, it highlights the required conditions to encourage the responsible development of nanomaterials, as well as reflects on the lack of consensus in terms of approaches and frameworks that could facilitate standardisation adoption, regulatory enforcement and industry intervention concerning nanomaterials.

Journal: Advances in experimental medicine and biology (2022)
Publication types: Journal Article
Influence of patch geometry, post-bark-extraction-treatment on bark recovery and standardizing number of sprouts for bark harvest from coppices in Cinnamomum zeylanicum blume: implications for sustainable harvesting.

Though cinnamomum zeylanicum is a very important commercial aromatic bark yielding and oldest known tree spice of india, there are hardly any studies to understand the nature of wound healing and bark recovery.Further, optimal number of sprouts to be retained under coppice system to maximize the bark yield per tree in c.Zeylanicum is not yet standardized.The present investigation was carried out to understand the influence of patch geometry and application of post-bark-extraction-protection treatments on bark regeneration in mature trees as well as to standardize an optimal number of sprouts to be retained under coppice system to maximize the bark yield per tree.In general, wound healing in c.Zeylanicum occurred from the edge of the blaze and was quicker in the narrower patch than the broader patch; application of bordeaux paste or neem seed kernel extract on the blazed area immediately after the bark extraction, resulted in significantly higher mean percent bark recovery and higher bark oil content than control.Allowing seven coppice sprouts per stem resulted in higher dry mass of bark per plant and higher bark oil than other treatments under coppice system.The results of the study would enable formulation of management strategies specifically for sustainable bark harvesting in cinnamomum species.

Journal: Environmental monitoring and assessment (2022)
Publication types: Journal Article
The CLP and PREP protease systems coordinate maturation and degradation of the chloroplast proteome in Arabidopsis thaliana.

A network of peptidases governs proteostasis in plant chloroplasts and mitochondria.This study reveals strong genetic and functional interactions in arabidopsis between the chloroplast stromal clp chaperone-protease system and the prep1,2 peptidases, which are dually localized to chloroplast stroma and the mitochondrial matrix.Higher order mutants defective in clp or prep proteins were generated and analyzed by quantitative proteomics and n-terminal proteomics (terminal amine isotopic labeling of substrates (tails)).Strong synergistic interactions were observed between the clp protease system (clpr1-2, clpr2-1, clpc1-1, clpt1, clpt2) and both prep homologs (prep1, prep2) resulting in embryo lethality or growth and developmental phenotypes.Synergistic interactions were observed even when only one of the prep proteins was lacking, suggesting that prep1 and prep2 have divergent substrates.Proteome phenotypes were driven by the loss of clp protease capacity, with little impact from the prep peptidases.Chloroplast n-terminal proteomes showed that many nuclear encoded chloroplast proteins have alternatively processed n-termini in prep1prep2, clpt1clpt2 and prep1prep2clpt1clpt2.Loss of chloroplast protease capacity interferes with stromal processing peptidase (spp) activity due to folding stress and low levels of accumulated cleaved c tp fragments.Prep1,2 proteolysis of cleaved c tps is complemented by unknown proteases.A model for clp and prep activity within a hierarchical chloroplast proteolysis network is proposed.

Journal: The New phytologist (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.
Fibrillary Glomerulonephritis with Atypical Immunoglobulin M Deposits and Hypocomplementemia Revealed Human Immunodeficiency Virus Infection.

Fibrillary glomerulonephritis (fgn) is a rare form of glomerulonephritis, and the incidence in native renal biopsies is less than 1%.The diagnosis of fgn is defined by the ultrastructural finding of organized, randomly oriented, nonbranching fibrils with a diameter of 10-30 nm.Fgn is immune-mediated glomerulonephritis with predominant immunoglobulin (ig) g deposits.Hypocomplementemia is very rare.We report the case of a 68-year-old caucasian man with renal impairment, hematuria, subnephrotic proteinuria, hypocomplementemia (low c4, normal c3), and hypergammaglobulinemia.The kidney biopsy revealed a mesangial proliferative pattern with ig m deposits, and the electron microscopy demonstrated fgn.Upon further investigation, secondary causes, such as malignancy, monoclonal gammopathy, or autoimmune disease were excluded, and human immunodeficiency virus (hiv) infection was revealed.Only three cases with fgn associated with hiv infection without concurrent hepatitis c virus have been reported and all of them in already known medical records.Our patient received treatment with corticosteroids and highly active antiretroviral therapy, and the renal function improved.

Journal: Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (2021)
Publication types: Case Reports;Journal Article
Use of a positive psychology intervention (PPI) to promote the psychological well-being of children living in poverty: study protocol for a feasibility randomised controlled trial.

Introduction poverty has a detrimental influence on psychological well-being of children.Existing evidence shows that positive psychology interventions are possible to mitigate such impact.Despite criticisms that positive psychology resembles a scientific pollyannaism that promotes overly positivity, positive psychology is not the scientific pollyannaism that denies the difficulties and emotions that people may experience.Whereas, positive psychology acknowledges the difficulties and emotions, alongside with building up human resilience, strength and growth to face adversity.This study examined the feasibility of implementing a positive psychology intervention among hong kong chinese children living in poverty.Methods a feasibility randomised controlled trial will be conducted.A convenience sample of 120 children aged 13-17 years will be recruited from a community centre in kwai tsing district.Participants who are randomised into the experimental group will join a 1.5-hour workshop covering four positive psychology techniques: (1) gratitude visits/letters, (2) three good things, (3) you at your best and (4) using signature strengths.A booster intervention will be provided at 1 week.Control group participants will not receive any intervention.Assessments will be conducted at baseline and at 1-week, 1-month, 3-month and 6-month follow-ups.Analysis descriptive statistics will be used to calculate the feasibility measures.Effect sizes on psychological outcomes (ie, self-esteem, depressive symptoms and quality of life) will be estimated by mixed between-within subjects analysis of variance using partial eta squared with poverty (yes, no) entering into the model as a factor.Ethics and dissemination ethical approval has been obtained from the hong kong polytechnic university institutional review broad.We will obtain parental consent as our subjects are below 18 years old.Findings from this study will be disseminated via international publications and conferences.Trial registration number nct04875507.

Journal: BMJ open (2022)
Publication types: Clinical Trial Protocol;Journal Article;Research Support, Non-U.S. Gov't
A high-throughput assay for directly monitoring nucleolar rRNA biogenesis.

Studies of the regulation of nucleolar function are critical for ascertaining clearer insights into the basic biological underpinnings of ribosome biogenesis (rb), and for future development of therapeutics to treat cancer and ribosomopathies.A number of high-throughput primary assays based on morphological alterations of the nucleolus can indirectly identify hits affecting rb.However, there is a need for a more direct high-throughput assay for a nucleolar function to further evaluate hits.Previous reports have monitored nucleolar r rna biogenesis using 5-ethynyl uridine (5-eu) in low-throughput.We report a miniaturized, high-throughput 5-eu assay that enables specific calculation of nucleolar r rna biogenesis inhibition, based on co-staining of the nucleolar protein fibrillarin (fbl).The assay uses two si rna controls: a negative non-targeting si rna control and a positive si rna control targeting rna polymerase 1 (rnap1;polr1a), and specifically quantifies median 5-eu signal within nucleoli.Maximum nuclear 5-eu signal can also be used to monitor the effects of putative small-molecule inhibitors of rnap1, like bmh-21, or other treatment conditions that cause fbl dispersion.We validate the 5-eu assay on 68 predominately nucleolar hits from a high-throughput primary screen, showing that 58/68 hits significantly inhibit nucleolar r rna biogenesis.Our new method establishes direct quantification of nucleolar function in high-throughput, facilitating closer study of rb in health and disease.

Journal: Open biology (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Loss of Happiness for Land-Expropriated, Urbanised Residents: A Comparison Based on Multiple Groups.

Are land-expropriated, urbanised residents living happily?This question is not only related to the quality of urbanisation but also has important reference for evaluating the reform of the land acquisition system.On the basis of the chinese general social survey data in 2017 and 2018, the heck probit model, the ordered probit model and the mediating effect model were used to study the happiness and underlying mechanism of land-expropriated, urbanised residents.The results showed that the older the farmers are, the lower the probability of obtaining urban hukou through land acquisition, and women will be more likely to achieve household registration through land requisition.Education and party status have significant inhibitory effects on hukou conversion through land acquisition.A comparison among multiple groups indicated that the happiness level of each group is ranked as follows: residents who attained urban hukou through education and job recruitment > urban native residents > land-expropriated, urbanised residents > farmers; however, the happiness level of the latter two groups has no significant difference.The propensity score matching method was further used to reduce the endogeneity due to selection bias, and the results were still robust.The lower self-assessment of socioeconomic status indirectly caused the loss of happiness of land-expropriated, urbanised residents.However, the high living expectation 'suppressed' the negative effect of land acquisition on happiness to some extent.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Risk stratification of neurological decompression sickness in divers.

Introduction patent foramen ovale (pfo) is a risk factor of decompression sickness (dcs).However, data on risk stratification of divers with a pfo are sparse.This study sought to evaluate the risk of neurological dcs (dcsneuro), based on the presence and grade of a right-to-left shunt (rls).Methods a total of 640 divers were screened for a rls using tcd between 1/2006 and 4/2017.Rls was graded as low, medium, or high grade with two subgroups - after a valsalva maneuver or at rest.Divers were questioned about their dcs history.Survival analysis techniques were used to assess risk factors for unprovoked dcs.Results a rls was found in 258 divers (40.3 %).44 (17.1 %) divers with a rls experienced dcsneuro compared to 5 (1.3 %) divers without a rls (p <0.001).The proportion of dcsneuro increased from 4.6 % in the low-grade rls subgroup to 57.1 % in the subgroup with high-grade rls at rest.The hazard ratio for dcsneuro and rls was11.806 (p <0.001).Conclusions divers with a rls had a higher risk of dcsneuro and the risk increased with rls grade.We suggest that tcd is an appropriate method for rls screening and risk stratification in divers (tab.4, fig.2, ref.29).

Journal: Bratislavske lekarske listy (2022)
Publication types: Journal Article
Constrast-enhanced computed tomography radiomics predicts CD27 expression and clinical prognosis in head and neck squamous cell carcinoma.

This study aimed to construct a radiomics model that predicts the expression level of cd27in patients with head and neck squamous cell carcinoma (hnscc).Materials and methods genomic data and contrast-enhanced computed tomography (ct) images of patients with hnscc were downloaded from the cancer genome atlas and cancer imaging archive for prognosis analysis, image feature extraction, and model construction.We explored the potential molecular mechanisms underlying cd27expression and its relationship with the immune microenvironment and predicted cd27m rna expression in hnscc tissues.Using non-invasive, ct-based radiomics technology, we generated a radiomics model and evaluated its correlation with the related genes and hnscc prognosis.Results and conclusion the expression level of cd27in hnscc may significantly influence the prognosis of patients with hnscc.Radiomics based on contrast-enhanced ct is potentially effective in predicting the expression level of cd27.

Journal: Frontiers in immunology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Restoring antiviral immunity with adoptive transfer of ex-vivo generated T cells.

Of review latent viruses such as cytomegalovirus (cmv), epstein-barr virus (ebv) and adenovirus (adv) often reactivate in immunocompromised patients, contributing to poor clinical outcomes.A rapid reconstitution of antiviral responses via adoptive transfer of virus-specific t cells (vsts) can prevent or eradicate even refractory infections.Here, we evaluate this strategy and the associated methodological, manufacturing and clinical advances.Recent findings from the early pioneering but cumbersome efforts to isolate cmv-specific t cell clones, new approaches and techniques have been developed to provide quicker, safer and broader-aimed ex-vivo antigen-specific cells.New manufacturing strategies, such as the use of g-rex flasks or 'priming' with a library of overlapping viral peptides, allow for culturing greater numbers of cells that could be patient-specific or stored in cell banks for off-the-shelf applications.Rapid isolation of t cells using major histocompatibility complex tetramer or cytokine capture approaches, or genetic reprogramming of cells to target viral antigens can accelerate the generation of potent cellular products.Summary advances in the ex-vivo generation of vsts in academic medical centres and as off-the-shelf blood bank-based or commercially produced reagents are likely to result in broader accessibility and possible manufacturing cost reduction of these cell products, and will open new therapeutic prospects for vulnerable and critically ill immunocompromised patients.

Journal: Current opinion in hematology (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
The Influence of Enterprise Culture Innovation on Organizational Knowledge Creation and Innovation under the Ecological Environment.

With the continuous development of economy and society, ecological environmental governance has been put on the priority agenda.In the process of ecological environmental governance, the state, society, and enterprises bear different responsibilities, respectively.As the main body of social economy, in the development of enterprises, the protection of ecological environment is the due meaning of enterprise culture is always paid attention.Whether enterprises can achieve success is not only directly affected by the development strategy, management mode, business philosophy, management tools, and other aspects but also indirectly affected by its own cultural construction level.Although corporate culture has changed due to the development of the network environment, the challenges of corporate culture innovation in terms of values and cultural conflicts should not be underestimated.It can not only enhance the centripetal force of all the employees but also enhance the competitive advantage of the enterprise.In addition, corporate culture also plays a positive role in enhancing office efficiency and increasing production capacity and output.Starting from the role of corporate culture, this study studies the characteristics of corporate culture under the background of implementing ecological environmental governance, addresses the challenges of corporate culture innovation in the new environment, and puts forward the measures of corporate cultural innovation, which provides reference for corporate culture innovation.

Journal: Journal of environmental and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Relationship of Self Efficacy in Medication Understanding with Quality of Life among Elderly with Type 2 Diabetes Mellitus on Polypharmacy in Malaysia.

Self-efficacy (se) has been shown to be positively correlated with quality of life (qol) among patients with type 2 diabetes mellitus (t2dm).Medication understanding (mu) on the other hand, leads to good adherence that indirectly improves qol.Measuring self-efficacy in medication understanding is useful to ascertain patient’s confidence in medication adherence.However, there is a lack of studies on the relationship between self-efficacy in medication understanding with qol.This study aimed to determine the relationship between self-efficacy in medication understanding and qol, and the factors associated with qol in elderly with t2dm on polypharmacy.A cross-sectional study was conducted on these populations at primary care specialist clinic.Malay version of mu in se questionnaire (muse) was used.Higher scores showed a better understanding.A revised version diabetic quality of life-13 (rvdqol-13) questionnaire was used with lower scores indicating higher qol.A total of 321 patients participated, with the majority being male (58.3%), malay (84.7%), a predominant age group of 60−69 (75.7%) with mean age (±sd) of 66.7 (±0.286) years old.The median (iqr) of muse was high—30 (4)—while the rvdqol-13 was low—19 (8)—which demonstrated high qol.Inverse correlation was found between muse and qol (r −0.14, p < 0.01).Multiple linear regression analysis demonstrated that muse score (β −0.282; 95% ci: (−5.438, −2.581); p < 0.001), low-income group (β −0.144; 95% ci: (−3.118, −0.534); p = 0.006) and duration of medications ≥240 days (β −0.282; 95% ci: (−5.438, −2.581); p < 0.001) were associated with better qol, while medications ≥10 (β 0.109; 95% ci: 0.214, 4.462; p = 0.031) and those with pills and insulin (β 0.193; 95% ci: 1.206, 3.747; p < 0.001) were associated with poor qol.In conclusion, higher muse is associated with better qol.Findings suggest emphasizing self-efficacy in medication understanding in the management of elderly with t2dm on polypharmacy to improve qol.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't