syedzayyan/paper_mill_benchmark huggingface dataset:
Os1B11N12/C2N as an Efficient Electrocatalyst for Nitrogen Reduction Reaction.

Ammonia is one of the most important fertilizer feedstocks and chemical precursor besides a promising hydrogen carrier.However, the electrochemical reduction of nitrogen to ammonia is impeded by the low selectivity and high limiting potential of reported catalysts.Herein, the nitrogen reduction reaction (nrr) on os-doped bn cluster supported on c2n (os1b11n12/c2n) was investigated systematically based on density functional theory calculations.It was found that the adjustment of bn cluster on the upper d-band edge of os atom enabled the optimal adsorption strength for nrr intermediates.Consequently, os1b11n12/c2n exhibited high catalytic activity for nrr with the limiting potential of -0.34 v and a remarkable suppressive effect on the hydrogen evolution reaction.This work is not only beneficial for understanding the mechanism of nrr but also provides a fundamental guidance for rational design of catalysts for nrr.

Journal: ChemSusChem (2022)
Publication types: Journal Article
Not all lymphoid aggregates in chronic lymphocytic leukemia (CLL) patients are due to CLL!

Infection is a common cause of morbidity and mortality in chronic lymphocytic leukemia and should be considered when examining bone marrow specimens to identify a potentially treatable pathogen.

Journal: Clinical case reports (2021)
Publication types: Journal Article
The Effect of Parental Medical History on the Prevalence of Cerebrovascular Diseases in Their Children in an Iranian Population.

Introduction still a controversial issue, family history is known as a risk factor for the development of cerebrovascular diseases (cvd).In this study, we aimed to evaluate the relationship between parental history and risk of cvd in their offspring in iranian population.Methods isfahan cohort study (ics) included total 6504 healthy participants which were randomly selected through a two-stage cluster sampling method from three districts.The participants were followed prospectively for 10 years.The diagnosis of cvd were confirmed by expert panelist.Clinically validated history of cvd was established for definition of parental history of cvd.Types of history were categorized into paternal, maternal, both parents, and no history.Results the prevalence of cvd is generally higher among female offspring compared with male ones (p<0.001).The relative risk of cvd with maternal history was not significant (95%ci=0.95-2.29).By adjusted model analysis, history of cvd in both parents affected the risk of cvd in their male children (rr=2.13, p=0.033, 95%ci).By crude model analysis, maternal history of cvd (p=0.047), history of cvd in both parents (p=0.032), and maternal history of hypertension (p=0.005) were determined as risk factors of cvd in offspring.Indeed, the mean age of cvd in offspring decreases based on this order: history of hypertension in parents, paternal history of cvd in both parents, maternal history of cvd, and no history (p<0.001).Conclusion early and regular screening for cvd development is necessary in female offspring of the families with the present history of cvd from maternal side.This group are at risk and should be considered as the target group for screening and taking preventive measures.

Journal: Basic and clinical neuroscience (2018)
Publication types: Journal Article
Self-Adjustment of Hearing Aid Amplification for Lower Speech Levels: Independent Ratings, Paired Comparisons, and Speech Recognition.

Self-adjustment of hearing aid amplification enables wearers to customize the hearing aid output to match their preferences and could become an important tool for programming direct-to-consumer devices for people with mild-to-moderate hearing loss.One risk is that user-selected settings may provide inadequate audibility.This study assessed that risk by quantifying relationships between self-adjusted settings, subjective preferences, and speech recognition performance using speech at low levels in quiet, where achieving high speech audibility requires sufficient amplification.Method fifteen people with symmetric, mild-to-moderate sensorineural hearing loss self-adjusted hearing aid amplification while listening to speech in quiet at 45, 55, and 65 d ba.After self-adjustment, 11 participants made blinded ratings of their self-adjusted fit, their nal-nl2 prescriptive fit, and experimenter-created fits with reduced gain.Participants completed blinded paired comparisons and sentence recognition assessments using these settings.Results the gain of self-adjusted fits showed a large range of variability between participants.On average, self-adjusted gain was similar to nal-nl2 prescribed gain for input signals of 55 d ba and slightly greater than prescribed gain for 45-d ba signals.Speech recognition scores for nal-nl2 fits were consistently high, and differences in speech recognition results were strongly correlated with the overall preferences obtained from paired comparisons.Conclusions self-adjusted fits are highly variable between individuals for low-audibility conditions.Nonetheless, self-adjusted fits are at least as satisfactory as nal-nl2 fits, and listeners tend to disfavor settings that result in poorer speech recognition.The findings argue against concerns that self-adjustment will result in inadequate audibility compared to prescribed settings.

Journal: American journal of audiology (2022)
Publication types: Journal Article
Transfusion-associated graft-versus-host disease: A concise review.

Transfusion-associated graft-versushost disease (ta-gvhd) represents a rare fatal event observed in immunocompromised patients and immunocompetent individuals.The main clinical features of this transfusion reaction are pancitopenia and multiorgan failure (skin, liver, gut).The possible pathogenesis includes donor t lymphocyte proliferation in blood, their engraftment and host tissue attack.The purpose of this narrative review was analyzing the international guidelines for irradiation of cellular blood components to prevent ta-gvhd.A literature search was conducted using pub med articles published between january 2000 to july 2018.American, australian, british and japanese transfusion guidelines have been compared regarding clinical indications.The contribution of manuscripts has been focused on recipients of haematopoietic stem cell transplantation, severe cellular immunodeficient patients, fetuses and neonates, immunocompentent individuals.Furthermore, 348 cases of ta-gvhd in the last five decades have been documented according to a recent systematic review.The standard of care to prevent this complication is gamma or x irradiation of cellular blood products.New treatments with pathogen inactivation appear safe and effective against proliferating white blood cells and t cells.Further clinical and biological studies are necessary to better characterize immunocompetence of t cells and select alternative preventive strategies.

Journal: Hematology reports (2018)
Publication types: Journal Article
Histological and Immunohistochemical Analysis of the Effects of Topical Melatonin Treatment Associated with Collagen Sponge and rhBMP-2 Protein on Bone Remodeling.

Extensive bone defect healing is an important health issue not yet completely resolved.Different alternative treatments have been proposed but, in face of a critical bone defect, it is still very difficult to reach a complete regeneration, with the new-formed bone presenting all morphological and physiological characteristics of a normal, preinjury bone.Topical melatonin use has shown as a promising adjuvant for bone regeneration due to its positive effects on bone metabolism.Thus, to search for new, safe, biological techniques that promote bone repair and favor defect healing, we hypothesized that there is a synergistic effect of melatonin treatment associated with rh bmp-2 to guide bone regeneration.This study aimed to investigate bone repair effects of topical melatonin administration in different concentrations (1, 10, and 100 μg), associated or not with rh bmp-2.Surgical-induced bone defect healing was qualitatively evaluated through histopathological analysis by light microscopy.Additionally, quantitative stereology was performed in immunohistochemistry-prepared tissue to identify angiogenic, osteogenic, and osteoclastogenic factors.Quantification data were compared between groups by the anova/tukey test and differences were considered significant whenp< 0.05.Our results showed that the presence of the scaffold in the bone defect hindered the process of bone repair because in the group treated with "blood clot + scaffold" the results of bone formation and immunolabeling were reduced in comparison with all other groups (treated with melatonin alone or in association with rh bmp-2).Statistical analysis revealed a significant difference between the control group (bone defect + blood clot), and groups treated with different concentrations of melatonin in association with rh bmp-2, indicating a positive effect of the association for bone repair.This treatment is promising once it becomes a new safe alternative technique for the clinical treatment of fractures, bone defects, and bone grafts.Our results support the hypothesis of the safe use of the association of melatonin and rh bmp-2 and have established a safe and effective dose for this experimental treatment.

Journal: Biomolecules (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The pivotal regulatory factor circBRWD1 inhibits arsenic exposure-induced lung cancer occurrence by binding mRNA and regulating its stability.

Multiple studies have indicated that circular rnas (circ rnas) play a regulatory role in different stages of tumors by interacting with various molecules.With continuous in-depth research on the biological functions of circ rnas, increasing evidence has shown that circ rnas play important roles in carcinogenesis caused by environmental pollutants.However, the function and mechanism of circ rnas in arsenic exposure-induced lung cancer occurrence have not been reported.In this study, rna sequencing and q pcr assays revealed that the expression of circ brwd1 was decreased in beas-2b-as cells and multiple lung cancer cell lines.Silencing circ brwd1 promoted cell viability and proliferation, inhibited cell apoptosis, and accelerated the g0/g1 phase transition in beas-2b-as cells; however, these functions were abrogated by circ brwd1 overexpression.Mechanistically, under arsenic exposure, expression of decreased circ brwd1 led to enhanced stability of the m rna to which it directly binds (c-jun, c-myc, and cdk6 m rna), increasing its expression.This mechanism promotes the malignant transformation of lung cells and ultimately leads to lung cancer.Our findings thus reveal the molecular mechanism of arsenic carcinogenesis.

Journal: Molecular therapy oncolytics (2022)
Publication types: Journal Article
The prognostic value of ischemia-modified albumin in patients with sepsis.

Sepsis is a significant contributor of mortality all over the world.Emergency departments have a critical role for diagnosing a suspected sepsis in a patient, since early and proper administration of antibiotics may decrease mortality significantly.But, the unavailability of an objective and reliable diagnostic test is the major challenge of this critical issue.Aims the aim of this study is to evaluate the prognostic value of a novel biomarker, the ischemia-modified albumin (ima) in patients with sepsis and septic shock in emergency department.Subjects and methods this prospective, observational study included 81 patients with sepsis or septic shock and 75 controls.Sociodemographic characteristics of the patients, site of infection, ima levels, other biomarkers (procalcitonin, p h, lactate), mortality at 24-h and 28-day were evaluated.Results the serum ima levels in patient and control groups were 117.8 ± 85 iu/g and 115.8 ± 134.0 iu/g, respectively (p = 0.072).There was a weak but statistically significant positive correlation between ima and lactate levels (p = 0.009).The mortality rates of patient group at 24-h and 28 days were 21% and 79%, respectively, but serum ima levels were not found to be a prognostic marker to predict mortality.Conclusion the main reason for the similarity between groups regarding ima levels was thought to be associated with the distribution of the acute and chronic health problems other than sepsis in the control group.Emergency department physicians should not only depend on serum ima levels for predicting the prognosis of patients with sepsis or septic shock.

Journal: Nigerian journal of clinical practice (2021)
Publication types: Journal Article;Observational Study
The Species-Level Composition of the FecalBifidobacteriumandLactobacillusGenera in Indonesian Children Differs from That of Their Mothers.

The infant gut microbiota plays a critical role in early life growth and derives mainly from maternal gut and breast milk.This study aimed to analyze the differences in the gut microbiota, namely bifidobacteriumand lactobacilluscommunities at species level among breast milk as well as maternal and infant feces at different time points after delivery.Fifty-one mother-infant pairs from indonesia were recruited, and the breast milk and maternal and infant feces were collected and analyzed by high throughput sequencing (16s r rna,bifidobacteriumgro el and lactobacillusgro el genes).Pco a results showed bacterial composition was different among breast milk and maternal and infant feces within the first two years.The abundance of bifidobacteriumand bacteroideswere significantly higher in infant feces compared to their maternal feces from birth to two years of age, and maternal breast milk within six months after birth (p <0.05), whereas the abundance of blautia,prevotella, and faecalibacteriumwas higher in maternal feces compared to that in breast milk within six months and infant feces within one year after birth, respectively (p <0.05).The relative abundances of bacteroidesand lactobacilluswas higher and lower in infant feces compared to that in maternal feces only between one and two years of age, respectively (p <0.05).For bifidobacteriumcommunity at species level,b.Adolescentis, b.Ruminantium, b.Longum subsp.Infantis, b.Bifidum,and b.Pseudolongumwere identified in all samples.However, the profile of bifidobacteriumwas different between maternal and infant feces at different ages.The relative abundances of b.Adolescentisand b.Ruminantiumwere higher in maternal feces compared to those in infant feces from birth to one year of age (p <0.05), while the relative abundances of b.Longumsubsp.infantisand b.Bifidumwere higher in infant feces compared to those in maternal feces beyond three months, and the relative abundance of b.Pseudolongumwas only higher in infant feces between three and six months (p <0.05).For lactobacilluscommunity,l.Paragasserishowed higher relative abundance in infant feces when the infant was younger than one year of age (p <0.05).This study showed bacterial composition at the genus level and bifidobacteriumand lactobacilluscommunities at the species level were stage specific in maternal breast milk as well as and maternal and infant feces.

Journal: Microorganisms (2021)
Publication types: Journal Article
Using advance and emergency care plans during transfer decisions: A grounded theory interview study with care home staff.

Advance care planning has been identified as one of few modifiable factors that could reduce hospital transfers from care homes.Several types of documents may be used by patients and clinicians to record these plans.However, little is known about how plans are perceived and used by care home staff at the time of deterioration.Aim to describe care home staff experiences and perceptions of using written plans during in-the-moment decision-making about potential resident hospital transfers.Design qualitative semi-structured interviews analysed using the straussian approach to grounded theory.Setting/participants thirty staff across six care homes (with and without nursing) in the east and west midlands of england.Results staff preferred (in principle) to keep deteriorating residents in the care home but feared that doing so could lead to negative repercussions for them as individuals, especially when there was perceived discordance with family carers' wishes.They felt that clinicians should be responsible for these plans but were happy to take a supporting role.At the time of deterioration, written plans legitimised the decision to care for the resident within the home; however, staff were wary of interpreting broad statements and wanted plans to be detailed, specific, unambiguous, technically 'correct', understood by families and regularly updated.Conclusions written plans provide reassurance for care home staff, reducing concerns about personal and professional risk.However, care home staff have limited discretion to interpret plans and transfers may occur if plans are not specific enough for care home staff to use confidently.

Journal: Palliative medicine (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Postprandial effect of gastrointestinal hormones and gastric activity in patients with irritable bowel syndrome.

Altered gut regulation, including motor and secretory mechanisms, is characteristic of irritable bowel syndrome (ibs).The severity of postprandial symptoms in ibs patients is associated with discomfort and pain; gas-related symptoms such as bloating and abdominal distension; and abnormal colonic motility.The aim of this study was to assess the postprandial response, i.e., gut peptide secretion and gastric myoelectric activity, in patients with constipation-predominant ibs.The study was conducted on 42 ibs patients (14 males, 28 females, mean age 45.1 ± 15.3 years) and 42 healthy participants (16 males, 26 females, mean age 41.1 ± 8.7 years).The study assessed plasma gut peptide levels (gastrin, cck-cholecystokinin, vip-vasoactive intestinal peptide, ghrelin, insulin) and gastric myoelectric activity obtained from electrogastrography (egg) in the preprandial and postprandial period (meal-oral nutritional supplement 300 kcal/300 ml).Mean preprandial gastrin and insulin levels were significantly elevated in ibs patients compared to the control group (gastrin: 72.27 ± 26.89 vs.12.27 ± 4.91 pg/ml; p < 0.00001 and insulin: 15.31 ± 12.92 vs.8.04 ± 3.21 iu/ml; p = 0.0001), while vip and ghrelin levels were decreased in ibs patients (vip: 6.69 ± 4.68 vs.27.26 ± 21.51 ng/ml; p = 0.0001 and ghrelin: 176.01 ± 88.47 vs.250.24 ± 84.55 pg/ml; p < 0.0001).A nonsignificant change in the cck level was observed.Ibs patients showed significant changes in postprandial hormone levels compared to the preprandial state-specifically, there were increases in gastrin (p = 0.000), cck (p < 0.0001), vip (p < 0.0001), ghrelin (p = 0.000) and insulin (p < 0.0001).Patients with ibs showed reduced preprandial and postprandial normogastria (59.8 ± 22.0 vs.66.3 ± 20.2%) compared to control values (83.19 ± 16.7%; p < 0.0001 vs.86.1 ± 9.4%; p < 0.0001).In response to the meal, we did not observe an increase in the percentage of normogastria or the average percentage slow-wave coupling (apswc) in ibs patients.The postprandial to preprandial power ratio (pr) indicates alterations in gastric contractions; in controls, pr = 2.7, whereas in ibs patients, pr = 1.7, which was significantly lower (p = 0.00009).This ratio reflects a decrease in gastric contractility.Disturbances in the postprandial concentration of gut peptides (gastrin, insulin and ghrelin) in plasma may contribute to abnormal gastric function and consequently intestinal motility, which are manifested in the intensification of clinical symptoms, such as visceral hypersensitivity or irregular bowel movements in ibs patients.

Journal: Scientific reports (2023)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
MiR-34c acts as a tumor suppressor in non-small cell lung cancer by inducing endoplasmic reticulum stress through targeting HMGB1.

To investigate the role of mi r-34c in lung cancer.Methods the levels of micro rna-34c (mi r-34c) expression in non-small cell lung cancer (nsclc) tissue and cell lines were examined by the q rt-pcr assay.High mobility group box 1 (hmgb1) expression in nsclc was assessed by immunohistochemical analysis (ihc), q rt-pcr, and western blot assays.The effects of mi r-34c overexpression or hmgb1 knockdown on cell proliferation and apoptosis were evaluated by cck-8 and flow cytometry analysis, respectively.Cellular reactive oxygen species (ros) production in nsclc cells was detected using a ros kit.The levels of bax, p-erk, e if2α, gadd153, and ire1α expression in treated nsclc cells were measured by western blot assays.In addition, the interaction between mi r-34c and hmgb1 was verified by the dual-luciferase reporter assay.Results mi r-34c was only slightly expressed, while hmgb1 was highly expressed in nsclc tissues and cell lines.Overexpression of mi r-34c or knockdown of hmgb1 inhibited cell proliferation, promoted cell apoptosis, and induced er stress in nsclc cells.In terms of mechanism, mi r-34c negatively regulated hmgb1 expression by directly targeting the 3'-untranslated region (utr) of hmgb1 m rna.In addition, we proved that hmgb1 overexpression could block the effects of mi r-34c on nsclc cell proliferation, apoptosis, and er stress.Conclusion mi r-34c may suppress nsclc tumors by targeting hmgb1 m rna, promoting endoplasmic reticulum stress, and increasing ros levels.Our findings suggest that mi r-34c has a role in nsclc.

Journal: OncoTargets and therapy (2019)
Publication types: Journal Article
Hypoxia ameliorates brain hyperoxia and NAD+deficiency in a murine model of Leigh syndrome.

Leigh syndrome is a severe mitochondrial neurodegenerative disease with no effective treatment.In the ndufs4-/-mouse model of leigh syndrome, continuously breathing 11% o2(hypoxia) prevents neurodegeneration and leads to a dramatic extension (~5-fold) in lifespan.We investigated the effect of hypoxia on the brain metabolism of ndufs4-/-mice by studying blood gas tensions and metabolite levels in simultaneously sampled arterial and cerebral internal jugular venous (ijv) blood.Relatively healthy ndufs4-/-and wildtype (wt) mice breathing air until postnatal age ~38 d were compared to ndufs4-/-and wt mice breathing air until ~38 days old followed by 4-weeks of breathing 11% o2.Compared to wt control mice, ndufs4-/-mice breathing air have reduced brain o2consumption as evidenced by an elevated partial pressure of o2in ijv blood (pijv o2) despite a normal po2in arterial blood, and higher lactate/pyruvate (l/p) ratios in ijv plasma revealed by metabolic profiling.In ndufs4-/-mice, hypoxia treatment normalized the cerebral venous pijv o2and l/p ratios, and decreased levels of nicotinate in ijv plasma.Brain concentrations of nicotinamide adenine dinucleotide (nad+) were lower in ndufs4-/-mice breathing air than in wt mice, but preserved at wt levels with hypoxia treatment.Although mild hypoxia (17% o2) has been shown to be an ineffective therapy for ndufs4-/-mice, we find that when combined with nicotinic acid supplementation it provides a modest improvement in neurodegeneration and lifespan.Therapies targeting both brain hyperoxia and nad+deficiency may hold promise for treating leigh syndrome.

Journal: Molecular genetics and metabolism (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't