syedzayyan/paper_mill_benchmark huggingface dataset:
Design, synthesis, in vitro and in silico studies of some novel thiazole-dihydrofuran derivatives as aromatase inhibitors.

Aromatase inhibitors used against hormone-dependent breast cancer, especially in post-menopausal women, are very susceptible to the development of resistance due to their limited number and long-term use.In this study, it is aimed to obtain new aromatase inhibitors including thiazole and dihydrofuran ring systems.Synthesis of compounds (2a-2l) were performed according to literature methods.Their structures were elucidated by1h nmr,13c nmr and apci-ms spectroscopic methods.Mtt test was carried out to assess the cell proliferation effects of the different compounds on two different pulmonary cell lines (a549, ccd-19lu) and mammary cell line (mcf7).According to mtt assay, it was observed that the calculated ic50values of some compounds for the ccd-19lu cell line were found higher than for the a549 and mcf7 cell lines.Considering the viability results, it was found that the selected compounds (2a, 2c, 2e, 2g, 2h, 2l) showed favourable safety profile and have anticancer activities.Apoptotic activities of the selected compounds were investigated by flow cytometry analysis.And were found that have apoptotic effects on cancerous cell lines.In the light of this information, the aromatase inhibition potentials of 2g and 2l compounds, which are the most active derivatives, were examined in vitro and it was determined that they showed a similar inhibition profile with letrazole.Interaction modes between aromatase enzyme and compounds 2g and 2l were investigated by docking studies.In conclusion, findings of these study indicate that compounds 2g and 2l possess significant anticancer activity.

Journal: Bioorganic chemistry (2021)
Publication types: Journal Article
Anti-Microbial Antibody Response is Associated With Future Onset of Crohn's Disease Independent of Biomarkers of Altered Gut Barrier Function, Subclinical Inflammation, and Genetic Risk.

And aims altered host immune reactivity to microbial antigens is hypothesized to trigger the onset of crohn's disease (cd).We aimed to assess whether increased serum anti-microbial antibody response in asymptomatic first-degree relatives (fdrs) of cd patients is an independent risk factor for future cd development.Methods we measured host serum antibody response to 6 microbial antigens at enrollment (prometheus enzyme-linked immunosorbent assay test: anti-saccharomyces cerevisiae antibodies immunoglobulin a/immunoglobulin g, anti-omp c, anti-a4-fla2, anti-fla x, anti-cbir1) and derived the sum of positive antibodies (as).We used samples at enrollment of prospectively followed healthy fdrs from a nested case-control cohort of the crohn's and colitis canada genetics environment microbial project.Those who later developed cd (n = 77) were matched 1:4 by age, sex, follow-up duration, and geographic location with control fdrs remaining healthy (n = 307).To address our research aims, we fitted a multivariable conditional logistic regression model and performed causal mediation analysis.Results high baseline as (≥2) (43% of cases, 11% of controls) was associated with higher risk of developing cd (adjusted odds ratio, 6.5; 95% confidence interval, 3.4-12.7; p < .001).Importantly, this association remained significant when adjusted for markers of gut barrier function, fecal calprotectin, c-reactive protein, and cd-polygenic risk score, and in subjects recruited more than 3 years before diagnosis.Causal mediation analysis showed that the effect of high as on future cd development is partially mediated (42%) via preclinical gut inflammation.Conclusions our results suggest that increased anti-microbial antibody responses are associated with risk of future development of cd, independent of biomarkers of abnormal gut barrier function, subclinical inflammation, and cd-related genetic risks.This suggests that anti-microbial antibody responses are an early predisease event in the development of cd.

Journal: Gastroenterology (2021)
Publication types: Journal Article;Multicenter Study;Observational Study;Research Support, Non-U.S. Gov't
Role of Lymphotoxin-α Gene Polymorphism in Hepatitis C Virus-Related Chronic Liver Disorders.

Tumor necrosis factor (tnf) family includes lymphotoxin-alpha (lta) which is a pro-inflammatory cytokine which plays a role in hepatic fibrogenesis.Lta gene polymorphism plays a role in different inflammatory and immunomodulatory diseases.This polymorphism is also suggested to affect chronic hepatitis c (chc) infection course.Aim to study the contribution of lta gene polymorphism in different chronic hepatitis c stages and hepatocellular carcinoma risk.Patients and methods our study included 108 chronic hcv patients grouped according to the disease stage.Group (a): chc, group (b): liver cirrhosis (lc), group (c): lc with hcc, and group (d): healthy controls.Routine laboratory investigations, polymerase chain reaction (pcr) for quantification of hcv, abdominal ultrasonography, and liver stiffness measurement (lsm) were done.Child-turcotte-pugh, model for end-stage liver disease (meld), and fibrosis index based on 4 (fib-4) scores were calculated.We used the pcr-restriction fragment length polymorphism technique for lymphotoxin-α genotyping.Results the a/g genotype was predominant in all groups.In hcc patients, g/g genotype was more frequent (31.8%) than in the lc group (19.4%), chc group (17.8%), and controls (4.17%).A significant association was found between lta genotypes and the child classes in hcc (p 0.05).Hcc patients carrying a/g genotype had higher meld scores than other genotypes.Multivariate binary logistic regression analysis confirmed that lta g/g genotype and low platelet count were independent predictors for hcc development in patients with hcv-related lc.Conclusion detection of lta g/g genotype in chronic hcv patients could help to recognize high-risk patients for disease progression and hcc development.

Journal: Infection and drug resistance (2021)
Publication types: Journal Article
Abrasion Behavior of Different Charcoal Toothpastes on Human Dentin When Using Electric Toothbrushes.

The aim of this study was to investigate abrasion on human dentin after brushing with activated charcoal toothpastes.A self-designed brushing machine was used to brush five groups (group a: water, group b: sensodyne pro schmelz, group c: splat blackwood, group d: curaprox black is white, and group e: prokudent black brilliant) with electrically powered toothbrushes for 4 h.The abrasive dentin wear was calculated using profilometry data.Furthermore, thermogravimetric analyses and scanning electron microscopy were used to analyze the composition of the toothpastes.Mean dentin loss by brushing were (71 ± 28) μm (splat blackwood), (44 ± 16) μm (curaprox black is white), (38 ± 13) μm (prokudent black brilliant), (28 ± 14) μm (sensodyne pro schmelz), and (28 ± 13) μm (water).Groups a/b/d/e and group c each lie in one subset, which is statistically different from the other subset according to a post hoc tukey test (p= 0.05).Within the limitations, it can be concluded that the content of activated charcoal in charcoal toothpastes had little influence on the observed abrasive behavior, although one of the charcoal toothpastes showed the highest abrasion on dentin.

Journal: Dentistry journal (2022)
Publication types: Journal Article
Impact of War on Fertility and Infertility.

War causes more death and disability than many major diseases.There are few studies in the context of the deleterious impact of war on fertility potential; therefore, in this study, we tried to review articles about the adverse effects of war on male/ female fertility potential.Methods in this study, a total of 183 articles related to the effects of war on fertility potential were examined by a systematic search using known international medical databases.Results among these studies, there were limited studies on the effects of war on female infertility and most studies examined the effects of war on sperm parameters and male infertility.The physical and psychological trauma of war can increase the risk of infertility in men and women.Presence of reproductive system toxins in weapons, stressful periods of war and direct damage to the reproductive system can impair the fertility of men and women.The way war affects male fertility is not clear, but the higher degree of stress during wartime seems to play an important role.Using reproductive toxicants during the war also increases the risk of impairment in reproductive function in men.Some studies have shown the harmful effects of sulfur mustard as a war chemical toxin especially on sperm quality and male infertility.Oxidative stress induced by free radicals is a major mechanism for the direct effects of sulfur mustard on male infertility.Conclusion the study of past research suggests that exposure to war may be an independent risk factor for reproductive disorders and infertility in men.For female infertility, war leads to menstrual dysfunction.

Journal: Archives of Iranian medicine (2020)
Publication types: Journal Article;Review
Spatio-temporal epidemiology of emergency medical requests in a large urban area. A scan-statistic approach.

Pre-hospital care is provided by emergency medical services (ems) staff, the initial health care providers at the scene of disaster.This study aimed to describe the characteristics of ems callers and space-time distribution of emergency requests in a large urban area.Descriptive thematic maps of ems requests were created using an empirical bayesian smoothing approach.Spatial, temporal and spatio-temporal clustering techniques were applied to ems data based on kulldorff scan statistics technique.Almost 225,000 calls were registered in the ems dispatch centre during the study period.Approximately two-thirds of these calls were associated with an altered level of patient consciousness, and the median response time for rural and urban ems dispatches was 12.2 and 10.1 minutes, respectively.Spatio-temporal clusters of ems requests were mostly located in central parts of the city, particularly near the downtown area.However, high-response time clustered areas had a low overlap with these general, spatial clusters.This low convergence shows that some unknown factors, other than ems requests, influence the high-response times.The findings of this study can help policymakers to better allocate ems resources and implement tailored interventions to enhance ems system in urban areas.

Journal: Geospatial health (2021)
Publication types: Journal Article
A case of traumatic acute interhemispheric subdural hematoma due to injured dural branch of anterior cerebral artery.

The precise causes of traumatic acute interhemispheric subdural hematoma (aisdh) are unclear in most cases, and there are few cases, where the sources of bleeding are directly confirmed intraoperatively.We report a rare case of traumatic aisdh, in which a damaged dural branch of anterior cerebral artery (aca) to the cerebral falx was identified as the cause of bleeding during hematoma removal.Case description a 61-year-old man with a history of craniotomy for the left putaminal hemorrhage at the age of 50 fell from a bed, bruised his head, and lost consciousness.Computed tomography of the head showed aisdh of 2.5cm in thickness, which was removed through a parietal parasagittal craniotomy under the microscope.Intraoperatively, the bleeding source was revealed to be a damaged dural branch from aca to the cerebral falx.There was no rebleeding during his stay in our hospital.Conclusion in this case, intraoperative findings revealed that the cause of bleeding was a damage to the dural branch of aca.A vascular study is mandatory to rule out a vascular malformation in similar cases.

Journal: Surgical neurology international (2022)
Publication types: Case Reports;Journal Article
The mandate and work of ICRP Committee 2 on doses from radiation exposure.

The practical implementation of the international commission on radiological protection's (icrp) system of radiological protection requires the availability of appropriate methodology and data.Over many years, icrp committee 2 has provided sets of dose coefficients to allow users to evaluate equivalent and effective doses for radiation exposures of workers and members of the public.The methodology being applied in the calculation of doses is state-of-the-art in terms of the biokinetic models used to describe the behaviour of inhaled and ingested radionuclides, and the dosimetric models used to model radiation transport for external and internal exposures.This overview provides an outline of recent work and future plans, including publications on dose coefficients for adults, children, and in-utero exposures, with new dosimetric phantoms in each case.For the first time, icrp will publish dose coefficients for intakes of radon isotopes calculated using dosimetric models.Committee 2 is also working with committee 3 on dose coefficients for radiopharmaceuticals, and leading a cross-committee initiative to provide advice on the use of effective dose.The remit of committee 2 has now been widened to include all data requirements for the assessment of doses to humans and non-human biota.

Journal: Annals of the ICRP (2018)
Publication types: Journal Article;Review
Automated alert and activation of medical emergency team using early warning score.

Timely recognition of warning signs from deteriorating patients and proper treatment are important in improving patient safety.In comparison to the traditional medical emergency team (met) activation triggered by phone calls, automated activation of met may minimize activation delays.However, limited data are available on the effects of automated activation systems on the time from derangement to met activation and on clinical outcomes.The objective of this study was to determine the impact of an automated alert and activation system for met on clinical outcomes in unselected hospitalized patients.Methods this is an observational study using prospectively collected data from consecutive patients managed by the met at a university-affiliated, tertiary hospital from march 2013 to december 2019.The automated alert system automatically calculates the modified early warning score (mews) and subsequently activates met when the mews score is 7 or higher, which was implemented since august 2016.The outcome measures of interest including hospital mortality in patients with mews of 7 or higher were compared between pre-implementation and post-implementation groups of the automated alert and activation system in the primary analysis.The association between the implementation of the system and hospital mortality was evaluated with logistic regression analysis.Results of the 7678 patients who were managed by met during the study period, 639 patients during the pre-implementation period and 957 patients during the post-implementation period were included in the primary analysis.Met calls due to abnormal physiological variables were more common during the pre-implementation period, while met calls due to medical staff's worries or concern about the patient's condition were more common during the post-implementation period.The median time from deterioration to met activation was significantly shortened in the post-implementation period compared to the pre-implementation period (34 min vs.60 min, p < 0.001).In addition, unplanned icu admission rates (41.2% vs.71.8%, p < 0.001) was reduced during the post-implementation period.Hospital mortality was decreased after implementation of the automated alert system (27.2% vs.38.5%, p < 0.001).The implementation of the automated alert and activation system was associated with decreased risk of death in the multivariable analysis (adjusted or 0.73, 95% ci 0.56-0.90).Conclusions after implementing an automated alert and activation system, the time from deterioration to met activation was shortened and clinical outcomes were improved in hospitalized patients.

Journal: Journal of intensive care (2021)
Publication types: Journal Article
Robotic-assisted intracranial aneurysm treatment: 1 year follow-up imaging and clinical outcomes.

The use of robotics in medicine may enable increased technical accuracy, reduced procedural time and radiation exposure, and remote completion of procedures.We have previously described the first-in-human, robotic-assisted cerebral aneurysm treatment using the cor path grx robotic system.In this report we discuss our early experiences and outcomes using this robotic device for endovascular treatment of intracranial aneurysms using stent-assisted coil embolization and flow diversion.Methods the patient and disease characteristics, procedural details, and follow-up imaging and clinical outcomes of consecutive patients undergoing robotically-assisted intracranial aneurysm embolization between november 2019 and february 2020 are presented.Results six patients underwent robotically-assisted embolization of intracranial aneurysms.Four of the patients were treated with a neck-bridging stent (with or without coiling) and two patients were treated with a flow-diverting stent.Two patients were treated in the subacute period of subarachnoid hemorrhage and four patients were treated electively.All of the procedures could be completed robotically and there was no need for unplanned manual intervention.The technical success rate of the procedures was 100%.There was no morbidity or mortality associated with the procedures.One year follow-up imaging showed that four aneurysms were completely obliterated (raymond-roy occlusion classification (rroc) class i) and the remaining two were occluded with a residual neck (rroc class ii).Conclusions the corpath grx robotic system demonstrated a precise control over the microcatheter, wire and stent during aneurysm treatment.Robotic neuro-procedures seem to be safe and effective and demonstrate stable occlusion results in the midterm follow-up.

Journal: Journal of neurointerventional surgery (2022)
Publication types: Journal Article
Partially supervised P300 speller adaptation for eventual stimulus timing optimization: target confidence is superior to error-related potential score as an uncertain label.

Error-related potentials (err ps) have the potential to guide classifier adaptation in bci spellers, for addressing non-stationary performance as well as for online optimization of system parameters, by providing imperfect or partial labels.However, the usefulness of err p-based labels for bci adaptation has not been established in comparison to other partially supervised methods.Our objective is to make this comparison by retraining a two-step p300 speller on a subset of confident online trials using naïve labels taken from speller output, where confidence is determined either by (i) err p scores, (ii) posterior target scores derived from the p300 potential, or (iii) a hybrid of these scores.We further wish to evaluate the ability of partially supervised adaptation and retraining methods to adjust to a new stimulus-onset asynchrony (soa), a necessary step towards online soa optimization.Approach eleven consenting able-bodied adults attended three online spelling sessions on separate days with feedback in which soas were set at 160 ms (sessions 1 and 2) and 80 ms (session 3).A post hoc offline analysis and a simulated online analysis were performed on sessions two and three to compare multiple adaptation methods.Area under the curve (auc) and symbols spelled per minute (spm) were the primary outcome measures.Main results retraining using supervised labels confirmed improvements of 0.9 percentage points (session 2, p < 0.01) and 1.9 percentage points (session 3, p < 0.05) in auc using same-day training data over using data from a previous day, which supports classifier adaptation in general.Significance using posterior target score alone as a confidence measure resulted in the highest spm of the partially supervised methods, indicating that err ps are not necessary to boost the performance of partially supervised adaptive classification.Partial supervision significantly improved spm at a novel soa, showing promise for eventual online soa optimization.

Journal: Journal of neural engineering (2016)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Minimally Invasive Autologous Fascia Sling at the Midurethra: A Case Series.

Study objective the primary objective was to determine the improvement in stress urinary incontinence symptoms using autologous fascia lata sling placed at the midurethra.The secondary objective was to determine the presence of leg pain after harvest of fascia lata graft.Design case series.Setting rural academic tertiary care center.Patients all women who underwent an autologous fascia midurethral sling over a 1-year period between june 2019 and september 2020.Interventions autologous fascia lata midurethral sling.Measurements incontinence severity index, urodynamic distress inventory-6, and likert pain scale.Main results nineteen women received an autologous fascial sling at the midurethra using the described technique-16 fascia lata and 3 rectus fasciae.Mean improvement in incontinence severity index score was 6 points.Mean improvement in urodynamic distress inventory-6 and sui subscale scores was 14 and 53, respectively, surpassing the minimally important difference for each.Median follow-up time was 9 months (range 2-16).Leg pain at the harvest site was bothersome in 1 patient beyond 6 weeks.Median time to passing voiding trial was 4 days (range 1-13 days).Four patients (21%) had postoperative voiding dysfunction, 3 of which resolved after sling loosening at a mean of 60 days after sling placement.Conclusion midurethral autologous fascial sling placement significantly improves symptoms of sui but carries a risk of voiding dysfunction.Harvesting fascia lata using a fascial stripper is associated with minimal postoperative morbidity.

Journal: Journal of minimally invasive gynecology (2022)
Publication types: Journal Article
Diastolic Plateau - Invasive Hemodynamic Marker of Adverse Outcome Among Left Ventricular Assist Device Patients.

Diastolic plateau is an invasive hemodynamic marker of impaired right ventricular (rv) diastolic filling.The purpose of the current analysis was to evaluate the prognostic importance of this sign in left ventricular assist device (lvad) patients.Methods the analysis included all lvad patients who received continuous-flow lvad (heart mate 3) at the sheba medical center and underwent right heart catheterization (rhc) during follow up post-lvad surgery.Patients were dichotomized into 2 mutually exclusive groups based on a plateau duration cutoff of 55% of diastole.The primary end point of the current analysis was the composite of death, heart transplantation, or increase in diuretic dosage in a 12-month follow-up period post-rhc.Results study cohort included 59 lvad patients with a mean age of 57 (iqr 54-66) of whom 48 (81%) were males.Rhc was performed at 303 ± 36 days after lvad surgery.Patients with and without diastolic plateau had similar clinical, echocardiographic, and hemodynamic parameters.Kaplan-meier survival analysis showed that the cumulative probability of event at 1 year was 65 ± 49% vs.21 ± 42% for primary outcomes among patients with and without diastolic plateau (p log rank < 0.05 for both).A multivariate model with adjustment for age, intermacs score and ischemic cardiomyopathy consistently showed that patients with diastolic plateau were 4 times more likely to meet the study composite end point (hr = 4.35, 95% ci 1.75-10.83,p= 0.002).Conclusion diastolic plateau during rhc is a marker of adverse outcome among lvad patients.

Journal: Frontiers in cardiovascular medicine (2022)
Publication types: Journal Article