syedzayyan/paper_mill_benchmark huggingface dataset:
Hope pictured in drawings by patients newly diagnosed with advanced cancer.

Hope is an integral part of a dying person's needs and an important phenomenon that has not been satisfactorily explored.The tension between hope for a cure and the reality of being terminally ill is a paradox, which in the context of palliative cancer care, nurses and health care professionals must take into consideration.Objective the purpose of this study was to elucidate the phenomenon of hope and to investigate the lived experiences of hope among newly diagnosed patients with advanced cancer.Method the study used a phenomenological-visual method where drawings and post-drawing interviews were used.The participants were six patients who recently had been offered specialised palliative care treatment.They were five women and one man with different cancer diagnoses and between 30 and 82 years of age (median 65 years).The data consisted of six drawings and individual post-drawing interviews with the participants.The study was reported using the coreq checklist.Results the study revealed one main concern 'being in hope' and hope appeared in four different dimensions; internal, external, relational and transcendental.Hopelessness was present at all times.Conclusion hope pictured in drawings was expressed through colour, shape, lines, symbols and metaphors, and hope incorporated internal, external, relational and transcendental aspects.Hope was constantly fighting against hopelessness and hope integrated with past, present and future.Relevance to clinical practice drawings, as well as other visual representations, are suitable tools when trying to understand an ineffable phenomenon such as hope experienced by people newly diagnosed with cancer.

Journal: Journal of clinical nursing (2023)
Publication types: Journal Article
Conceptual physical education: A course for the future.

The conceptual physical education (cpe) innovation began in the mid-20th century as an alternative approach to college-level, activity-only basic instruction classes.In addition to physical activity sessions, cpe courses (classes) use text material and classroom sessions to teach kinesiology concepts and principles of health-related fitness and health-enhancing physical activity.Cpe courses are now offered in nearly all college programs as either required or electives classes.Two decades later, the high school cpe innovation began, and kindergarten-8 programs followed.In this commentary, i argue that historian roberta park was correct in her assessment that physical education has the potential to be the renaissance field of the 21st century.Scientific contributions of researchers in kinesiology will lead the way, but science-based cpe and companion fitness education programs that align with physical education content standards and fitness education benchmarks will play a significant role.Cpe courses have been shown to be effective in promoting knowledge, attitudes, and out-of-school physical activity and have the potential to elevate physical education as we chart the course of our future.

Journal: Journal of sport and health science (2021)
Publication types: Historical Article;Journal Article
Cancer; Pathophysiology and Stress Modulation (Cancer, Therapeutic Interventions).

The purpose of this review is to describe the myriad complications of cancer and its therapies to emphasize the pathophysiological need for prehabilitation.Data sources the information presented in this review is from applicable, peer-reviewed scientific articles.Conclusion cancer itself renders negative effects on the body, most notably unintentional weight loss and fatigue.Cancer treatments, especially surgical interventions, can cause detrimental short- and long-term impacts on patients, which translate to suboptimal treatment outcomes.Prehabilitation can be used to improve patient health prior to anticancer therapies to improve treatment tolerance and efficacy.Implications for nursing practice nurses play an important role in the treatment of patients with cancer throughout the cancer care continuum.Many nurses are already aiding their patients in cancer prehabilitation through education.By describing common impairments amenable to multimodal prehabilitation, nurses may better advocate for their patients and can become even more involved in this aspect of care.

Journal: Seminars in oncology nursing (2022)
Publication types: Review;Journal Article
Digital spacer data driven COPD inhaler adherence education: The OUTERSPACE proof-of-concept study.

Pressurized metered dose inhalers are recommended to be used in combination with spacers, yet inhaler technique and adherence are poor.A novel digital "smart" spacer can record spacer use and technique errors and could facilitate personalized education.In this proof-of-concept study, we assessed the usability of the digital spacer and explored its effects on inhaler technique, adherence, long-term systemic drug exposure and clinical outcomes in copd.Usability was deemed high.One month after personalized digital spacer inhaler education, the mean number of errors per patient per day decreased with 36%, from 6.40 errors/day to 4.07 errors/day (p = 0.038).Drug exposure was confirmed by bioanalytical scalp hair analysis of formoterol.No significant change in clinical outcomes was observed.This study demonstrates the digital spacer's potential value in inhaler education, but larger, longer-term studies are required.

Journal: Respiratory medicine (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Developing an active lifestyle for children considering the Saudi vision 2030: The family's point of view.

Motivating children to lead a healthy and active lifestyle is a family mission and a responsibility shared by society.This study is important in developing the family's role in promoting children's active lifestyle.This study aims to develop the role of the family in promoting an active lifestyle for children in light of the saudi vision 2030.The sample included 405 parents who filled out an online survey about their children aged 3-12 years.The results show families' lack of interest in applying the who standards and the guidelines of the saudi ministry of health regarding children's regular daily physical activity.The families are reluctant to involve children in sports clubs.The parents desire to employ crews that enhance the movement and recreational activities of children in shopping centers and parks.The results also show that the presence of the father and mother together inside the house and their educational level have an impact on the effectiveness of the positive reinforcement of the active lifestyle of the children.To promote an active lifestyle for children, there is a need to determine why some families are hesitant to enroll their children in sports clubs.Additionally, there is a need to develop media and awareness campaigns for families in order to achieve the desired goals of developing an active lifestyle for children, which are approved by the who and saudi ministry of health standards and are consistent with families' low educational levels.

Journal: PloS one (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Sperm-oviduct interactions: Key factors for sperm survival and maintenance of sperm fertilizing capacity.

Although millions or even billions of sperm are deposited in the female genital tract, only very few sperm reach the oocyte, and only one single spermatozoon will successfully fertilize.During the journey of the sperm within the female genital tract, the interactions between spermatozoa and fallopian tube are critical for sperm selection, sperm survival, and maintenance of sperm fertilizing capacity.Results this review will provide a comprehensive overview of the latest findings regarding sperm transport and behavior of sperm within the oviduct, sperm selection in the oviduct, the formation of the sperm reservoir, and the release of sperm in the presence of the oocyte.It will primarily focus on recent novel insights on sperm-oviduct interactions, which have been obtained by cutting-edge technologies under in vivo or near in vivo conditions.Conclusions the comprehensive analysis of the findings to date will elucidate the complex molecular changes in the tubal epithelium, which are induced by the presence of the sperm and will highlight how the epithelial cells of this organ affect transport, behavior, and function of sperm.This knowledge is essential for scientists and clinicians involved in assisted reproductive technologies.

Journal: Andrology (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't
Work hard and sleep better: Work autonomy attenuates the longitudinal effect of workaholism on sleep problem among Chinese working adults.

The prevalence of workaholism has negative consequences on human health.Lack of sleep, a well-known problem among adults in modern society, is often attributed to overwork as a result of workaholism.Yet there is a lack of empirical research examining how and when workaholism will lead to sleep problems.To answer this question and to examine the longitudinal effect of workaholism on sleep in china, we investigate the mediating role of perceived evening responsibilities of work and the moderating effect of work autonomy.Two hundred and five chinese working adults (58.0% female) voluntarily completed the online questionnaires at time 1 (t1) and time 2 (t2; 1-month later).Results showed that workaholism at t1 had a significant and positive correlation with sleep problem at t2.Further analysis suggested that perceived evening responsibilities of work fully mediated the relationship between workaholism and sleep problem.Work autonomy was shown to buffer the positive effect of workaholism on perceived evening responsibilities of work and attenuate the indirect effect of workaholism on sleep problem.While workers should be made aware of the negative impact of workaholism on sleep, organizations should also consider interventions to enhance employees' autonomy and control of their work.

Journal: Global mental health (Cambridge, England) (2023)
Publication types: Journal Article
Clinical study of pulmonary CT lesions and associated bronchiectasis in 115 convalescent patients with novel coronavirus pneumonia (COVID-19) in China.

A total of 115 convalescent inpatients with covid-19 were enrolled.According to the results of scans of lung lesions via computed tomography (ct), the patients were divided into mild, moderate, and severe groups.The clinical data of the patients were collected, including age, gender, finger pulse oxygen pressure, ventricular rate, body temperature, etc.The correlation between the clinical indicators and the lesions of high-resolution ct (hrct) and bronchiectasis was analyzed.Among the 115 patients, 82 had no bronchiectasis and 33 had bronchiectasis.The bronchodilation-prone layers mainly included the left and right lower lobe of the lung.The probability of branching in the inflamed area was greater than that in the noninflamed area in patients with covid-19.There were significant differences in gender, ct lesion range, and number of incidents of bronchiectasis between noninflamed and inflamed areas (p< 0.05).Moreover, there were significant differences in age, total proportion of ct lesions, volume of ct lesions, and total number of patients with bronchiectasis among the three groups (p< 0.05).Ct lesion range was positively correlated with the total number of patients with bronchiectasis and patient age (respectively,r= 0.186,p< 0.05;r= 0.029,p< 0.05).The lesion range in hrct images of lungs in patients with covid-19 is correlated with bronchodilation.The larger the lesion, the higher the probability of bronchiectasis and the more incidents of bronchiectasis.

Journal: Canadian journal of physiology and pharmacology (2021)
Publication types: Journal Article
Intra-body Networks and Molecular Communication Networks in Diagnostic Sciences.

Intra-body transmission networks are proposed to be composed of nanostructured or micro-sized detectors placed within the body to monitor health and distribute drugs.Transplanted biosensors are the potential options for monitoring the body for the detection of particular ailments and determining a diagnosis with the help of a doctor.Biological systems inside the body remain intricately integrated and interact primarily through biochemical interactions.Thus, the continuous communication performance and intra-body molecular nanonetworks coordinate essential functions within the human body.Spontaneous intra-body molecular nanonetworks, on the other hand, have yet to be investigated using sophisticated tools of information and communication concepts.We intend to understand the exquisite molecular networking that exists within us to design and develop pragmatic, effective interaction for evolving nanonetworks and also to lay the groundwork for the progression of groundbreaking diagnosis and therapeutic methodologies inspired by technological tools, which have the potential to be helpful in future nanotechnologies and bioinspired molecular communication (mc) applications.

Journal: Cureus (2022)
Publication types: Journal Article;Review
Computational exploration of molecular receptive fields in the olfactory bulb reveals a glomerulus-centric chemical map.

Progress in olfactory research is currently hampered by incomplete knowledge about chemical receptive ranges of primary receptors.Moreover, the chemical logic underlying the arrangement of computational units in the olfactory bulb has still not been resolved.We undertook a large-scale approach at characterising molecular receptive ranges (mrrs) of glomeruli in the dorsal olfactory bulb (d ob) innervated by the mor18-2 olfactory receptor, also known as olfr78, with human ortholog or51e2.Guided by an iterative approach that combined biological screening and machine learning, we selected 214 odorants to characterise the response of mor18-2 and its neighbouring glomeruli.We found that a combination of conventional physico-chemical and vibrational molecular descriptors performed best in predicting glomerular responses using nonlinear support-vector regression.We also discovered several previously unknown odorants activating mor18-2 glomeruli, and obtained detailed mrrs of mor18-2 glomeruli and their neighbours.Our results confirm earlier findings that demonstrated tunotopy, that is, glomeruli with similar tuning curves tend to be located in spatial proximity in the d ob.In addition, our results indicate chemotopy, that is, a preference for glomeruli with similar physico-chemical mrr descriptions being located in spatial proximity.Together, these findings suggest the existence of a partial chemical map underlying glomerular arrangement in the d ob.Our methodology that combines machine learning and physiological measurements lights the way towards future high-throughput studies to deorphanise and characterise structure-activity relationships in olfaction.

Journal: Scientific reports (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Web-Based Peer Navigation for Men with Prostate Cancer and Their Family Caregivers: A Pilot Feasibility Study.

This study assessed the feasibility, acceptability and potential effects of true north peer navigation (pn)—a web-based peer navigation program for men with prostate cancer (pc) and their family caregivers.A one-arm, pre-post pilot feasibility study was conducted at two cancer centres in canada.Participants were matched through a web-app with a specially trained peer navigator who assessed needs and barriers to care, provided support and encouraged a proactive approach to health for 3 months.Descriptive statistics were calculated, along with paired t-tests.True north pn was feasible, with 57.9% (84/145) recruitment, 84.5% (71/84) pre-questionnaire, 77.5% (55/71) app registration, 92.7% (51/55) match and 66.7% (34/51) post-questionnaire completion rates.Mean satisfaction with peer navigators was 8.4/10 (sd 2.15), mean program satisfaction was 6.8/10 (sd 2.9) and mean app usability was 60/100 (sd 14.8).At 3 months, mean ± se patient/caregiver activation had improved by 11.5 ± 3.4 points (p = 0.002), patient quality of life by 1.1 ± 0.2 points (p < 0.0001), informational support by 0.4 ± 0.17 points (p = 0.03), practical support by 0.5 ± 0.25 points (p = 0.04) and less need for support related to fear of recurrence among patients by 0.4 ± 19 points (p = 0.03).The true north web-based peer navigation program is highly feasible and acceptable among pc patients and caregivers, and the associated improvements in patient and caregiver activation are promising.A randomized controlled trial is warranted to determine effectiveness.

Journal: Current oncology (Toronto, Ont.) (2022)
Publication types: Journal Article;Multicenter Study;Research Support, Non-U.S. Gov't
Injectable, Tough Alginate Cryogels as Cancer Vaccines.

A covalently crosslinked methacrylated (ma)-alginate cryogel vaccine has been previously shown to generate a potent response against murine melanoma, but is not mechanically robust and requires a large 16g needle for delivery.Here, covalent and ionic crosslinking of cryogels are combined with the hypothesis that this will result in a tough ma-alginate cryogel with improved injectability.All tough cryogels can be injected through a smaller, 18g needle without sustaining any damage, while covalently crosslinked-only cryogels break after injection.Cytosine-phosphodiester-guanine (cp g)-delivering tough cryogels effectively activate dendritic cells (dcs).Granulocyte macrophage colony-stimulating factor releasing tough cryogels recruit four times more dcs than blank gels by day 7 in vivo.The tough cryogel vaccine induces strong antigen-specific cytotoxic t-lymphocyte and humoral responses.These vaccines prevent tumor formation in 80% of mice inoculated with her2/neu-overexpressing dd breast cancer cells.The ma-alginate tough cryogels provide a promising minimally invasive delivery platform for cancer vaccinations.

Journal: Advanced healthcare materials (2018)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
Fluorescent cyclophanes and their applications.

With the serendipitous discovery of crown ethers by pedersen more than half a century ago and the subsequent introduction of host-guest chemistry and supramolecular chemistry by cram and lehn, respectively, followed by the design and synthesis of wholly synthetic cyclophanes-in particular, fluorescent cyclophanes, having rich structural characteristics and functions-have been the focus of considerable research activity during the past few decades.Cyclophanes with remarkable emissive properties have been investigated continuously over the years and employed in numerous applications across the field of science and technology.In this review, we feature the recent developments in the chemistry of fluorescent cyclophanes, along with their design and synthesis.Their host-guest chemistry and applications related to their structure and properties are highlighted.

Journal: Chemical Society reviews (2022)
Publication types: Journal Article;Review
Control of a two-DOF parallel robot with unknown parameters using a novel robust adaptive approach.

Model-based methods lose their performance in confronting with model uncertainties and disturbances.Accordingly, some degrees of adaptation to the involved conditions are required.In this paper, a novel robust adaptive scheme is proposed which guarantees the simultaneous identification and control of a system in the presence of external disturbances.Thereafter, the suggested algorithm is implemented on a 2-dof spherical parallel robot as a stabilizer device.By identifying unknown parameters of jacobian matrix, the relative identification error is obtained as 0.0207.Applying external excitations to the base, the ratio of end-effector to base orientation is acquired as 0.091, demonstrating proper stabilization in comparison with other two well-known methods.The proposed structure also reveals a reliable performance in tracking desired paths for the end-effector euler angles.

Journal: ISA transactions (2021)
Publication types: Journal Article
Mathematical modeling of HIV-HCV co-infection model: Impact of parameters on reproduction number.

Hepatitis c virus (hcv) and human immunodeficiency virus (hiv) are both as classified blood-borne viruses since they are transmitted through contact with contaminated blood.Approximately 1.3 million of the 2.75 million global hiv/hcv carriers inject drugs (pwid).Hiv co-infection has a harmful effect on the progression of hcv, resulting in greater rates of hcv persistence after acute infection, higher viral levels, and accelerated progression of liver fibrosis and end-stage liver disease.In this study, we developed and investigated a mathematical model for the dynamical behavior of hiv/aids and hcv co-infection, which includes therapy for both diseases, vertical transmission in hiv cases, unawareness and awareness of hiv infection, inefficient hiv treatment follow-up, and efficient condom use.methods:positivity and boundedness of the model under investigation were established using well-known theorems.The equilibria were demonstrated by bringing all differential equations to zero.The associative reproduction numbers for mono-infected and dual-infected models were calculated using the next-generation matrix approach.The local and global stabilities of the models were validated using the linearization and comparison theorem and the negative criterion techniques of bendixson and dulac, respectively.results:the growing prevalence of hiv treatment dropout in each compartment of the hiv model led to a reduction in hiv on treatment compartments while other compartments exhibited an increase in populations.in dually infected patients, treating hcv first reduces co-infection reproduction number rech, which reduces liver cancer risk.conclusions:from the model's results, we infer various steps that policymakers could take to reduce the number of mono-infected and co-infected individuals.

Journal: F1000Research (2022)
Publication types: Journal Article