syedzayyan/paper_mill_benchmark huggingface dataset:
A Tale of 2 Units: Lessons in Changing the Care Delivery Model.

In response to patient care quality and satisfaction concerns, a hospital determined the need to change the care delivery model on some inpatient units.Two pilot units adopted 2 different models of care.The authors describe the change project, successful outcomes, and lessons learned.

Journal: The Journal of nursing administration (2016)
Publication types: Journal Article
MR imaging features of diffuse intrinsic pontine glioma and relationship to overall survival: report from the International DIPG Registry.

This study describes imaging features of diffuse intrinsic pontine glioma (dipg) and correlates with overall survival (os) and histone mutation status in the international dipg registry (idipgr).Methods four hundred cases submitted to the idipgr with a local diagnosis of dipg and baseline mri were evaluated by consensus review of 2 neuroradiologists; 43 cases were excluded (inadequate imaging or alternative diagnoses).Agreement between reviewers, association with histone status, and univariable and multivariable analyses relative to os were assessed.Results on univariable analysis imaging features significantly associated with worse os included: extrapontine extension, larger size, enhancement, necrosis, diffusion restriction, and distant disease.On central review, 9.5% of patients were considered not to have dipg.There was moderate mean agreement of mri features between reviewers.On multivariable analysis, chemotherapy, age, and distant disease were predictors of os.There was no difference in os between wild-type and h3 mutated cases.The only imaging feature associated with histone status was the presence of ill-defined signal infiltrating pontine fibers.Conclusions baseline imaging features are assessed in the idipgr.There was a 9.5% discordance in dipg diagnosis between local and central review, demonstrating need for central imaging confirmation for prospective trials.Although several imaging features were significantly associated with os (univariable), only age and distant disease were significant on multivariable analyses.There was limited association of imaging features with histone mutation status, although numbers are small and evaluation exploratory.

Journal: Neuro-oncology (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Comparison of Clinical Characteristics, Natural History and Predictors of Disease Progression in Patients With Degenerative Mitral Stenosis Versus Rheumatic Mitral Stenosis.

Mitral annular calcification (mac) is a common echocardiographic finding and an increasingly recognized cause of degenerative mitral stenosis (dms).However, little is known about the clinical characteristics and disease progression in dms, particularly in comparison with rheumatic mitral stenosis (rms).We retrospectively reviewed 203 consecutive patients with mitral stenosis (113 with dms and 90 with rms) who underwent echocardiography at our institution between january 2014 and december 2017.We compared the clinical characteristics and disease progression between the 2 groups.In addition, we analyzed the predictors of disease progression (defined as annual progression rate of a mean gradient >0 mm hg/year) among patients with dms.Patients with dms were significantly older and had higher prevalence of atherosclerotic comorbidities than those with rms.During the median follow-up period of 2.2 years, the annual progression rates were comparable (0.8 ± 0.8 mm hg/year in dms vs 1.0 ± 1.2 mm hg/year in rms; p = 0.32) and were highly variable (0.0 to 3.5 mm hg/year in dms and 0.0 to 5.5 mm hg/year in rms) within both groups among disease progression.In dms patients, atherosclerotic comorbidities and lower initial mean gradient were significantly associated with disease progression even after adjustment by age and sex.There was no significant difference in the disease progression according to the circumferential mac severity determined by echocardiography among dms.In conclusion, dms disease progression was slow but highly variable, similar to that of rms.In patients with dms, the baseline mac severity did not correlate with disease progression, suggesting the importance of follow-up echocardiography regardless of the mac severity.

Journal: The American journal of cardiology (2021)
Publication types: Comparative Study;Journal Article
Synthesis of Unsymmetrical Ketones Using Chelation-Controlled Sequential Substitution ofN-Triazinylamide/Weinreb Amide by Organometallic Reagents.

N-(2,4-dimethoxy-1,3,5-triazinyl)amide was found to exhibit similar behavior to n-methoxy-n-methylamide (weinreb amide) but higher reactivity for nucleophilic substitution by organometallic reagents.Triazinylamide suppresses overaddition, leading to the formation of a tertiary alcohol by the chelating ability of the triazinyl and carbonyl groups.Ureas possessing both triazinylamino and methoxy(methyl)amino groups underwent sequential nucleophilic substitution with different organometallic reagents, which furnished unsymmetrical ketones without any detectable tertiary alcohols.

Journal: ACS omega (2022)
Publication types: Journal Article
Life course longitudinal growth and risk of knee osteoarthritis at age 53 years: evidence from the 1946 British birth cohort study.

To examine the relationship between height gain across childhood and adolescence with knee osteoarthritis in the mrc national survey of health and development (nshd).Materials and methods data are from 3035 male and female participants of the nshd.Height was measured at ages 2, 4, 6, 7, 11 and 15 years, and self-reported at ages 20 years.Associations between (1) height at each age (2) height gain during specific life periods (3) super-imposition by translation and rotation (sitar) growth curve variables of height size, tempo and velocity, and knee osteoarthritis at 53 years were tested.Results in sex-adjusted models, estimated associations between taller height and decreased odds of knee osteoarthritis at age 53 years were small at all ages - the largest associations were an or of knee osteoarthritis of 0.9 per 5 cm increase in height at age 4, (95% ci 0.7-1.1) and an or of 0.9 per 5 cm increase in height, (95% ci 0.8-1.0) at age 6.No associations were found between height gain during specific life periods or the sitar growth curve variables and odds of knee osteoarthritis.Conclusions there was limited evidence to suggest that taller height in childhood is associated with decreased odds of knee osteoarthritis at age 53 years in this cohort.This work enhances our understanding of osteoarthritis predisposition and the contribution of life course height to this.

Journal: Osteoarthritis and cartilage (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Incidence of spontaneous intracranial hypotension in a community: Beverly Hills, California, 2006-2020.

Spontaneous intracranial hypotension is diagnosed with an increasing frequency, but epidemiologic data are scarce.The aim of this study was to determine the incidence rate of spontaneous intracranial hypotension in a defined population.Methods using a prospectively maintained registry, all patients with spontaneous intracranial hypotension residing in beverly hills, california, evaluated at our medical center between 2006 and 2020 were identified in this population-based incidence study.Our medical center is a quaternary referral center for spontaneous intracranial hypotension and is located within 1.5 miles from downtown beverly hills.Results a total of 19 patients with spontaneous intracranial hypotension were identified.There were 12 women and seven men with a mean age of 54.5 years (range, 28 to 88 years).The average annual incidence rate for all ages was 3.7 per 100,000 population (95% confidence interval [ci]: 2.0 to 5.3), 4.3 per 100,000 for women (95% ci, 1.9 to 6.7) and 2.9 per 100,000 population for men (95% ci, 0.8 to 5.1).Conclusion this study, for the first time, provides incidence rates for spontaneous intracranial hypotension in a defined population.

Journal: Cephalalgia : an international journal of headache (2022)
Publication types: Journal Article
Onsite detection of plant viruses using isothermal amplification assays.

Plant diseases caused by viruses limit crop production and quality, resulting in significant losses.However, options for managing viruses are limited; for example, as systemic obligate parasites, they cannot be killed by chemicals.Sensitive, robust, affordable diagnostic assays are needed to detect the presence of viruses in plant materials such as seeds, vegetative parts, insect vectors, or alternative hosts and then prevent or limit their introduction into the field by destroying infected plant materials or controlling insect hosts.Diagnostics based on biological and physical properties are not very sensitive and are time-consuming, but assays based on viral proteins and nucleic acids are more specific, sensitive, and rapid.However, most such assays require laboratories with sophisticated equipment and technical skills.By contrast, isothermal-based assays such as loop-mediated isothermal amplification (lamp) and recombinase polymerase amplification (rpa) are simple, easy to perform, reliable, specific, and rapid and do not require specialized equipment or skills.Isothermal amplification assays can be performed using lateral flow devices, making them suitable for onsite detection or testing in the field.To overcome non-specific amplification and cross-contamination issues, isothermal amplification assays can be coupled with crispr/cas technology.Indeed, the collateral activity associated with some crispr/cas systems has been successfully harnessed for visual detection of plant viruses.Here, we briefly describe traditional methods for detecting viruses and then examine the various isothermal assays that are being harnessed to detect viruses.

Journal: Plant biotechnology journal (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't
Social anxiety and narrowed attentional breadth toward faces.

The amount of information that can be perceived and processed will be partly determined by attentional breadth (i.e., the scope of attention), which might be narrowed in social anxiety due to a negative attentional bias.The current study examined the effects of stimulus valence on socially anxious individuals' attentional breadth.Seventy-three undergraduate students completed a computerized dual-task experiment during which they were simultaneously presented with a facial picture at the center of the screen and a black circle (i.e., a target) at the periphery.Participants' task was to indicate the gender of the model in the picture and the location of the peripheral target.The peripheral target was presented either close to or far from the central picture.Higher levels of social anxiety were significantly associated with greater difficulties detecting the target presented far from the central facial pictures, suggesting that social anxiety is associated with narrowed attentional breadth around social cues.Narrowing of attentional breadth among socially anxious individuals might hamper their ability to process all available social cues, thereby perpetuating social anxiety.

Journal: Emotion (Washington, D.C.) (2015)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Assessment of Clinical Decision Support System Efficiency in Spinal Neurosurgery for Personalized Minimally Invasive Technologies Used on Lumbar Spine.

The aim of the studywas to assess clinical decision support system (cdss) in spinal surgery for personalized minimally invasive technologies on lumbar spine.Materials and methods the prospective study involved 59 patients operated on using cdss based on a personalized surgical algorithm considering patient-specific parameters of lumbar segments.Among them, 11 patients underwent total disk replacement (tdr), 25 and 23 patients had minimally invasive (mi-tlif) and open (o-tlif) dorsal rigid stabilization, respectively, according to an original technology.The comparative analysis was carried out using retrospective findings of 196 patients operated on involving tdr (n=42), mi-tlif (n=79), and o-tlif (n=75).The efficiency of cdss medical algorithms was assessed by pain syndrome in the lumbar spine and lower limbs, as well as by patients' functional status on discharge according to odi, 3 and 6 months after the operation.Results the comparison by gender characteristics and anthropometric data revealed no significant intergroup differences among the groups under study (p>0.05).Intergroup analysis of functional status by odi, pain intensity in lower limbs and lumbar spine showed better clinical outcomes in patients operated using cdss compared to a retrospective group (p<0.05): 6 months after tdr and o-tlif, and 3 months after mi-tlif.Conclusion the study findings demonstrated high efficiency of cdss developed for personalized surgical treatment of patients with degenerative lumbar spine diseases taking into consideration individual biometric parameters of lumbar segments.

Journal: Sovremennye tekhnologii v meditsine (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Efficacy and safety of lurasidone in adolescents and young adults with schizophrenia: A pooled post hoc analysis of double-blind, placebo-controlled 6-week studies.

The aim of this pooled analysis was to evaluate the efficacy and safety of lurasidone in the treatment of an acute exacerbation of schizophrenia in adolescents and young adults.Methods the six pooled studies in this analysis used similar study designs and outcome measures.Patients (aged 13-25 years) were randomized to 6 weeks of double-blind, placebo-controlled treatment with lurasidone in fixed doses of 40, 80, 120, or 160 mg.The primary efficacy endpoint was week 6 change in the positive and negative syndrome scale (panss) total score; secondary efficacy endpoints included week 6 change in the clinical global impression-severity scale.Results the safety population consisted of 537 patients (mean age: 18.1 years); 82.6% of patients completed the studies.Treatment with lurasidone was significantly better than placebo at all doses (p < 0.001) for change in the panss total score at week 6.Placebo-adjusted panss scores ranged from -9.4 to -16.1 (effect sizes: 0.53-0.90), with effect sizes increasing at higher doses.For lurasidone (combined doses), three adverse events occurred with a frequency of ≥5% (nausea: 13.5%; somnolence: 12.1%; akathisia: 10.1%).At last observation carried forward (locf)-endpoint weight gain of ≥7% was similar for lurasidone versus placebo (3.6 vs.4.7%).Minimal median changes were observed at endpoint in cholesterol, -2.0 mg/d l; triglycerides, 0.0 mg/d l; and glucose, 0.0 mg/d l.Conclusions in adolescents and young adults with schizophrenia, treatment with lurasidone in doses of 40-160 mg/d was a safe, well-tolerated, and effective treatment.Short-term treatment with lurasidone was associated with minimal effects on weight and metabolic parameters.

Journal: European psychiatry : the journal of the Association of European Psychiatrists (2021)
Publication types: Journal Article;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
Evaluation of the Playing Time Benefits of Foreign Players in the Big-5 European Football Leagues.

To explore the benefits that foreign players bring to their clubs, this study used foreign players in the big-5 european leagues (2013/2014-2017/2018 seasons) as samples and constructed a benefit model based on playing time and game points to evaluate the contribution of foreign players to their clubs in different leagues.The results showed the following: 1) from the 2013/2014 season to the 2017/2018 season, foreign players in the bundesliga had the highest playing time benefits (ptbs) (0.526 ± 0.012), followed by foreign players in la liga (0.523 ± 0.014), the premier league (0.518 ± 0.011), serie a (0.500 ± 0.012) and ligue 1 (0.486 ± 0.011); 2) foreign players from south america had the highest ptbs in the big-5 leagues, while those from africa had the lowest ptbs.However, among the different leagues, there were no significant differences in the ptbs of foreign players from the same continent; 3) ptbs of foreign players in the forward position were lower than those of foreign players in the defender position; 4) the country that produced foreign players in the big-5 leagues with the highest total ptbs was brazil, followed by argentina, spain and france.Additionally, the top 15 countries by total ptbs qualified for either the 2014 or the 2018 world cup final.

Journal: Journal of human kinetics (2022)
Publication types: Journal Article
Metformin: Expanding the Scope of Application-Starting Earlier than Yesterday, Canceling Later.

Today the area of application of metformin is expanding, and a wealth of data point to its benefits in people without carbohydrate metabolism disorders.Already in the population of people leading an unhealthy lifestyle, before the formation of obesity and prediabetes metformin smooths out the adverse effects of a high-fat diet.Being prescribed at this stage, metformin will probably be able to, if not prevent, then significantly reduce the progression of all subsequent metabolic changes.To a large extent, this review will discuss the proofs of the evidence for this.Another recent important change is a removal of a number of restrictions on its use in patients with heart failure, acute coronary syndrome and chronic kidney disease.We will discuss the reasons for these changes and present a new perspective on the role of increasing lactate in metformin therapy.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article;Review
Preparation and characterization of gelatin/zein nanofiber films loaded with perillaldehyde, thymol, or ɛ-polylysine and evaluation of their effects on the preservation of chilled chicken breast.

Three edible food packaging films loaded with perillaldehyde (p), thymol (t), or ɛ-polylysine (ɛ-pl) in gelatin/zein (g/z) nanofibers were prepared and characterized.Their effects on the preservation of chilled chicken breast were evaluated.Results showed that the addition of perillaldehyde, thymol, and ɛ-polylysine improved the morphology and diameter of the g/z.Loading with perillaldehyde improved the elongation and tensile strength of the g/z/p by 18% and 55%, respectively.The water vapor permeability and oxygen permeability of the g/z/p were lower than those of the g/z/t and g/z/ɛ-pl.X-ray diffraction, differential scanning calorimetry suggested that perillaldehyde enhanced the thermal stability of the g/z/p.Measurements of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt), total volatile basic nitrogen, and total viable bacterial counts demonstrated that the g/z/p had good bio-compatibility and effectively prolonged the shelf life of chilled chicken breasts by over 6 days.Therefore, the g/z/p developed herein has potential application in chilled meat packaging.

Journal: Food chemistry (2022)
Publication types: Journal Article
Promyelocytic Leukemia Proteins Regulate Fanconi Anemia Gene Expression.

Promyelocytic leukemia (pml) protein is the core component of subnuclear structures called pml nuclear bodies that are known to play important roles in cell survival, dna damage responses, and dna repair.Fanconi anemia (fa) proteins are required for repairing interstrand dna crosslinks (icls).Here we report a novel role of pml proteins, regulating the icl repair pathway.We found that depletion of the pml protein led to the significant reduction of damage-induced fancd2mono-ubiquitination and fancd2foci formation.Consistently, the cells treated with si rna against pml showed enhanced sensitivity to a crosslinking agent, mitomycin c.Further studies showed that depletion of pml reduced the protein expression of fanca,fancg, and fancd2via reduced transcriptional activity.Interestingly, we observed that damage-induced chk1 phosphorylation was severely impaired in cells with depleted pml, and we demonstrated that chk1 regulates fanca,fancg, and fancd2transcription.Finally, we showed that inhibition of chk1 phosphorylation further sensitized cancer cells to mitomycin c.Taken together, these findings suggest that the pml is critical for damage-induced chk1 phosphorylation, which is important for fa gene expression and for repairing icls.

Journal: International journal of molecular sciences (2021)
Publication types: Journal Article
Histopathological changes of pulmonary vascular remodeling in dogs affected with pulmonary hypertension secondary to degenerative mitral valve disease.

Introduction/objectives pulmonary hypertension (ph) can cause pulmonary arterial remodeling.Medial remodeling is a structural change of the pulmonary artery seen with ph.Hyperplasia and hypertrophy of pulmonary arterial smooth muscle cells (smcs) are suggested as causes of medial remodeling.To demonstrate the histopathological changes of the pulmonary artery in dogs affected with ph secondary to degenerative mitral valve disease (dmvd) compared with dmvd without ph and control dogs.Animals lung samples obtained from the carcasses of 19 older small-breed dogs (control, n = 5; dmvd, n = 7; dmvd + ph, n = 7).Materials and methods lung tissue sections were stained with hematoxylin and eosin, masson's trichrome, and proliferating cell nuclear antigen (pcna) immunohistochemistry.Results the internal diameters of the pulmonary artery in the three groups were not different.Masson's trichrome staining revealed no collagen deposition in the intimal layer of the pulmonary artery in all dogs.The external diameter, percentage of medial thickness (%mt), percentage of smc layer and collagen deposition areas, average number of smcs, and the percentage of pcna positive cells (%pcna) of the pulmonary artery were increased in the dmvd and dmvd + ph groups compared with the control group.The %pcna in the dmvd + ph group was significantly decreased when compared with the dmvd group.Conclusions medial remodeling was found in left-sided heart failure dmvd dogs with and without ph.The medial remodeling in dmvd dogs with and without ph is related to smc hyperplasia, hypertrophy, and collagen deposition, leading to an increased medial layer thickness of the pulmonary artery.

Journal: Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology (2021)
Publication types: Journal Article