syedzayyan/paper_mill_benchmark huggingface dataset:
Research on the Efficiency Evaluation of Cross-Organizational Knowledge Synergy in Industry University Cooperation Based on BP Neural Network Algorithm

The difference of decision-making knowledge among members is conducive to the successful realization of group cooperative production.In the actual production, if the different knowledge environments between organizations can cooperate and penetrate each other, the common knowledge of groups can be formed, which is a key step to successfully solve the social and economic problems of public resources.The final efficiency of cross-organizational knowledge collaboration is the key to measure the success or failure of collaboration.Because the cross-organizational knowledge synergy efficiency of industry university cooperation is the result of the cross-influence of many factors, the general linear regression model is difficult to describe the relationship between these influencing factors and knowledge synergy efficiency.Based on the analysis of the importance of cross-organizational knowledge sharing efficiency evaluation of industry university cooperation, this study constructs the efficiency evaluation index system from different angles.At the same time, based on the field investigation of the index system, bp network model is established to effectively evaluate the collaborative efficiency.

Journal: Mathematical Problems in Engineering (2022)
Publication types: Research Article;
Rapid Identification of Tobacco Mildew Based on Random Forest Algorithm

In order to further improve the identification efficiency of tobacco mildew, a rapid identification model of tobacco mildew based on random forest algorithm was proposed in this study.In order to ensure the feasibility and pertinence of the model study, this study takes redried leaf tobacco as the research object, selects high-temperature and high-humidity environment as the experimental conditions, and obtains the sample data of the degree of tobacco mildew under different experimental conditions.At the same time, this paper constructs a rapid identification model of tobacco mildew with the help of random forest algorithm.Through the model experimental results, it is found that the accuracy of the model for the rapid identification of training samples can reach 93.82%, while the accuracy of independent testing is 94.84%.The experimental results fully reflect the availability and efficiency of the random forest algorithm model in the rapid identification of tobacco mildew.

Journal: Scientific Programming (2022)
Publication types: Research Article;
Quality Control in the Clinical Medical Laboratory Based on Mobile Medical Edge Computing

Today, the it departments of many healthcare organizations are suffering from data storage and network speed.Doctors diagnose patients to help them out, and this treatment process needs to be well managed.Clinical trial data are the main basis for judging the patient’s condition in the medical process.With the rapid development of clinical laboratory technology in china, important achievements have been made in medicine.Clinical hospitals use a large number of different types of testing reagents and equipment, and the accuracy of testing data has become a key issue for testing results.The accuracy of testing data comes from the zero error of clinical testing, derived from the rigor and operational rigor of the testers in clinical testing.This article is dedicated to the quality control analysis and research based on mobile medical edge computing in clinical trials.This article introduces the relevant theories of mobile medical edge computing technology and quality control methods, with reference to the study on the general medical students’ clinical competency in problem‐solving, communication skills, procedure, history, and physical examination and critical and non‐critical indicators in objective structured clinical examination (osce).In addition, a routine testing group and a quality control group for strengthening important aspects of medical testing were designed to conduct comparative experiments.Experiments have proved that the quality control group for strengthening the important links of medical testing has a higher index than the routine testing group in all aspects.Among them, the detection accuracy rate can reach up to 99.48%, which is of great significance for the improvement of the detection link of the patient’s condition and the follow‐up diagnosis and treatment link.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
PTPN18 Stimulates the Development of Ovarian Cancer by Activating the PI3K/AKT Signaling

To illustrate the functions of protein tyrosine phosphatase nonreceptor type 18 (ptpn18) in the progression of ovarian cancer and the potential molecular mechanism.Methods.Differential ptpn18 expression in ovarian cancer samples was determined.Following ptpn18 knockdown, changes in proliferation and migration in ovarian cancer cells were detected.Nude mice with ovarian cancer were used to uncover the effects of ptpn18 on ovarian cancer growth in vivo.Results.Ptpn18 was significantly upregulated in ovarian cancer samples and linked to pathological staging and metastasis rate.Ptpn18 displayed prognostic and diagnostic potentials in ovarian cancer.Knockdown of ptpn18 and treatment of the pi3k inhibitor could inhibit proliferative and migratory abilities in ovarian cancer cells.Moreover, ptpn18 was capable of inactivating pi3k/akt signaling.In vivo knockdown of ptpn18 suppressed ovarian cancer growth in nude mice.Conclusions.Ptpn18 is upregulated in ovarian cancer, which stimulates the malignant development by activating pi3k/akt signaling.The ptpn18 level is also associated with pathological staging and metastasis in ovarian cancer patients, which may be utilized as a hallmark predicting the malignant level.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
PSMB5 Alleviates Ulcerative Colitis by Inhibiting ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis

Ulcerative colitis (uc) is a chronic inflammatory disease.Intestinal mucosal injury is a significant factor in uc.Pyroptosis is a kind of programmed cell death induced by inflammatory caspases.Proteasome 20s subunit beta 5 (psmb5) promotes cell viability.The purpose of this study was to determine the impact of psmb5 on intestinal mucosal injury and to elucidate the underlying processes in dextran sulfate sodium- (dss-) induced uc mice.Kunming (km) mice received 3% dss for 5 days to induce uc.We collected clinical symptoms, body weight, colon length, and histological changes.Mda (malondialdehyde) and sod (superoxide dismutase) levels were determined using an elisa assay.Rt-pcr was used to assess the expression of il-1β and il-18.Psmb5 demonstrated a significant effect against uc by increasing body weight and colon length and decreasing dai (disease activity index), colon macroscopic damage index (cmdi), histological injury scores, and reactive oxygen species (ros), mda, and sod levels, thereby alleviating histopathological changes and inhibiting oxidative stress.Hiec-6 cells were exposed to lipopolysaccharide (lps) condition with or without psmb5, along with caspase-1 inhibitor (z-vad-fmk), nlrp3 inhibitor (mcc950), and ros scavenger n-acetylcysteine (nac).The viability of the cells, the release of lactate dehydrogenase (ldh), and intracellular ros generation were determined using assay kits.Western blot analysis was used to determine the levels of nlrp3, asc, cleaved caspase-1 (p20), pro-il-1β, il-1β, pro-il-18, and il-18.Psmb5 overexpression enhanced the inflammatory damage in lps-treated hiec-6 cells by activating the nlrp3 inflammasome and mediating pyroptosis, as demonstrated by increased ldh release and lower cell viability, as well as increased expression of nlrp3, asc, cleaved caspase-1 (p20), il-1, and il-18.Meanwhile, nac protected hiec-6 cells from lps-induced damage by reversing the activation of the nlrp3 inflammasome-mediated pyroptosis.In conclusion, psmb5 may lower hiec-6 cell susceptibility to lps and ameliorate uc-induced hiec-6 cell damage by decreasing ros generation and hence inhibiting nlrp3-mediated pyroptosis.

Journal: Disease Markers (2022)
Publication types: Review Article;
Protective Role of Amiodarone on Reperfusion Arrhythmia in Patients of Acute Myocardial Infarction with Percutaneous Coronary Intervention Treatment

With the development and popularity of percutaneous coronary intervention (pci), ischemia-reperfusion injury (iri) has attracted more and more clinical attention.Reperfusion arrhythmia (ra), one of the common manifestations during and after pci, can affect the postoperative cardiac function of patients with acute myocardial infarction (ami).Therefore, effective intervention on ra has important clinical significance.This study observed the effect of amiodarone on reperfusion arrhythmia (ra) after percutaneous coronary intervention (pci) in patients with acute myocardial infarction (ami) and explored its possible mechanism.The results showed that amiodarone had good clinical efficacy in the prevention of ra in patients with ami after pci, and it could reduce the levels of serum il-6, hs-crp, ck-mb, and c tn i in patients and reduce the damage caused by reperfusion, thereby reducing the occurrence of ra.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Prognostic Value of Stem Cell Index-Related Characteristics in Primary Hepatocellular Carcinoma

The objective of this study is to form a cancer stem cell index‐based model to stratify hcc risk and predict survival.After screening the tumor genome atlas (tcga) of liver and normal liver tissue samples, we obtained differentially expressed genes (degs).We employed a weighted correlation network analysis (wgcna) and differentially expressed genes were studied in hcc to find the modules most associated with cancer stem cells (m rnasi).At the same time, gene ontology and kyoto genome encyclopedia (kegg) were used for functional annotation and combined with lasso, univariate, and multivariate cox regression analyses, a prediction model of key module genes of cancer stem cells was developed.The model’s clinical efficacy was measured using the c index, calibration curve, multiindex roc curve, and clinical decision curve.Wgcna found that black modules were most correlated with tumour stem cell index.Seven genes (csdc2, gna14, lgi2, mmrn1, pde2a, selp, and stk32b) were filtered by univariate, lasso, and multivariate cox regression analyses to establish the primary hcc model.The survival analysis and roc curve in the tcga training and validation cohort showed good performance.The independent prognostic factor of primary hcc was risk score, according to univariate and multivariate cox regression analyses.It is found that the stem cell index model of 7 genes could predict factors independently, indicating that signatures of the stem cell will play a significant role in liver cancer survival prediction and risk stratification.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Observation of the Effect of Focused Psychological Intervention Combined with Standardized Pain Nursing on Postoperative Pain Levels and Depression and Anxiety in Patients with Intestinal Obstruction

The purpose of this study was to investigate the effect of targeted psychological intervention combined with standardized pain care on postoperative pain, depression, and anxiety in patients with intestinal obstruction.Methods.84 patients with intestinal obstruction hospitalized at our hospital from october 2019 to february 2021 were randomly divided into study and control groups.The patients in the control group were treated with routine nursing, and the patients in the study group were treated with focused psychological intervention combined with standardized pain nursing.The pain degree (vas), depression and anxiety (sds, sas) score, sleep quality (psqi) score, and nursing satisfaction of the two groups before and after intervention were calculated.Results.Before intervention, no significant differences in vas score between the study and control groups were observed.The vas score of 6 h, 12 h, 24 h, and 48 h dry prognosis in the study group was lower than that in the control group.There was no significant difference in the scores of sds and sas between two groups.After intervention, the scores of sds and sas in the study group were lower than those in the control group.After intervention, the scores of daytime dysfunction, hypnotic drugs, sleep disorders, sleep efficiency, sleep time, and sleep quality in the study group were significantly lower than those in the control group.The scores of nursing state, nursing technique, nurse-patient communication, and inspection observation in the study group were higher than those in the control.Conclusion.The intervention of focused psychological intervention combined with standardized pain nursing on patients with intestinal obstruction can effectively relieve their negative emotion and reduce the degree of postoperative pain.In addition, it can improve patients’ sleep quality and enhance patients’ satisfaction with all kinds of nursing work.

Journal: Disease Markers (2022)
Publication types: Research Article;
Nursing Process Design of Intravenous Thrombolysis in Elderly Patients with Acute Cerebral Infarction

The economy of contemporary society is developing rapidly and the society is making continuous progress.The population is aging and diet structure is also adjusted.Acute cerebral infarction(aci) in the elderly has become a common disease that seriously threatens the health of the elderly.Therefore, research on nursing of senile aci is of great significance.Nursing is essential in the thrombolytic therapy of cerebral infarction.This article aims to study the process design of intravenous thrombolytic nursing for elderly patients with aci and the conclusions are as follows: the nursing process has a good nursing effect.This increased the barthel index of elderly patients with aci after intravenous thrombolysis care by 15.8 compared with that before care.Compared with the traditional nursing mode, the nursing course and cost are significantly reduced.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Modified Lamaze Breathing Reduces Abdominal Pain in Patients during Colonoscopy

To study the effects of modified lamaze breathing on abdominal pain experienced during colonoscopy.Methods.Eighty-five patients who underwent common colonoscopy at our hospital between march 2021 and may 2021 were selected and randomly divided into the lamaze group ( n = 40 ) and a control group ( n = 45 ).Their basic clinical information was collected, and the bowel cleanliness, the time for the endoscope to reach the ileocecal junction, and the degree of abdominal pain of the two groups were compared.Results.No significant difference was observed in age, gender, bowel cleanliness, and time of endoscope to reach the ileocecal junction between the two groups.However, the degree of abdominal pain (anal region, descending sigmoid colon junction, splenic flexure, and hepatic flexure) was significantly lower in the lamaze group compared with the control group.Conclusion.Modified lamaze breathing demonstrated promising effectiveness in reducing abdominal pain during colonoscopy and improving the quality of the examination.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
miR-335-5p Inhibits Progression of Uterine Leiomyoma by Targeting ARGLU1

Studies have demonstrated that mi r-335-5p exhibits an essential role in the progress of multiple tumors, including thyroid cancer, pancreatic cancer, and non-small-cell lung cancer.However, the possible expression, the detailed role, and the underlying mechanisms of mi r-335-5p in uterine leiomyoma (ul) still remained unclear.Therefore, the present study was designed to investigate the mechanism and function of mi r-335-5p in ul.In our study, micro rna-335-5p (mi r-335-5p) is significantly downregulated in ul tissues and ul cell lines, especially in hcc1688 and sk-ut-1 cells.Functionally, overexpression of mi r-335-5p notably inhibits the viability of ul cell lines by cck-8 assay.Besides, upregulation of mi r-335-5p inhibits proliferation of ul cell lines by colony formation assay and decreases the protein levels of pcna and ki-67 detected by western blot assay.In addition, overexpression of mi r-335-5p induces ul cell cycle arrest at g1 phase.Upregulation of mi r-335-5p decreases the levels of cyclin a1, cyclin b1, and cyclin d2 and upregulates the expression of p27 protein.Additionally, upregulation of mi r-335-5p promotes the apoptosis of ul cell lines, increases the protein levels of bax, cleaved caspase-3, and cleaved caspase-9, and decreases the protein expression of bcl-2.Moreover, arginine and glutamate-rich protein 1 (arglu1) is predicted as a target of mi r-335-5p by encori and mi rdb and confirmed by dual-luciferase reporter assay.Arglu1 is negatively associated with mi r-335-5p.Furthermore, overexpression of arglu1 partly restores the effects of mi r-335-5p mimic on the viability, proliferation, cell cycle, and apoptosis of ul cell lines.To conclude, mi r-335-5p may play a repressive role in ul by targeting arglu1 and serve as a potential therapeutic target for the treatment of ul.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
miR-216b-5p Inhibited the Progression of Experimental Optic Neuritis via Downregulating FAS

Present study mainly explored the effect of mi r-216b-5p on experimental optic neuritis and mechanism.Methods.Female c57bl/6 mice were utilized to establish the eae model.Mi r-216b-5p expression was measured by rt-q pcr.Protein expression was evaluated via western blot.Inflammatory infiltration score was analyzed by he staining.Visual function was assessed by measuring the okr.Flow cytometry assay was conducted to measure the percentage of il-17 cells.Elisa was utilized to evaluate the immune factor.Results.The eae mouse model was successfully established.The eae score of mice began to increase in eae group after 11 days of mog35-55 and cfa immunization.The degree of inflammatory cell infiltration in eae mice was higher than that in normal mice.Compared with normal mice, the number of microglia and astrocytes was raised in eae mice.Mi r-216b-5p expression was obviously declined and fas expression was obviously raised in eae.Compared with nc group, demyelination scores and axonal loss were markedly declined in mi r-216b-5p mimic group.Il-17a concentration and the percentage of il-17 cells were obviously declined in mi r-216b-5p mimic group.Fas was predicted to be regulated by mi r-216b-5p by target scan, and luciferase reporter assay confirmed this prediction.In addition, overexpression of fas exacerbated experimental optic neuritis by promoting the inflammatory response and th17 cell differentiation, and mi r-216b-5p reversed this effect.Conclusions.Mi r-216b-5p downregulated fas and inhibited the progression of experimental optic neuritis via promoting the inflammatory response and th17 cell differentiation.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
MIP-1α Level and Its Correlation with the Risk of Left Atrial Remodeling in Patients with Atrial Fibrillation

The aim of this study is to investigate the expression level of macrophage inflammatory protein‐1 α (mip‐1 α ) in atrial fibrillation patients and its correlation with the risk of left atrial remodeling.A total of 64 atrial fibrillation patients admitted to our hospital from april 2020 to december 2021 were prospectively selected as the case group and 61 healthy subjects who received physical examination during the same period were selected as the control group.Serum mip‐1 α level was determined by a double‐antibody sandwich enzyme‐linked immunosorbent assay.Serum mip‐1 α expression levels were compared between the case and the control groups.The case group was divided into high‐level and low‐level groups according to the serum mip‐1 α median.Simultaneously, the sociodemographic data, clinical data, and left atrial remodeling indexes of the patients were collected in the case group.The pearson correlation analysis was applied to analyze the correlation between the serum mip‐1 α level and the risk of left atrial remodeling in patients with atrial fibrillation.The serum mip‐1 α level was significantly higher in the case group than that in the control group ( p &lt; 0.05), high‐level group (≥2.14 pg/m l, 32 cases), and low‐level group (&lt;2.14 pg/m l, 32 cases).There were significant differences in the anteroposterior diameter, upper and lower diameter, left and right diameter of the left atrium, left atrial volume, volume index, left atrial global ejection fraction, and sphericity between the low‐level and high‐level groups ( p &lt; 0.05).The pearson correlation analysis showed that serum mip‐1 α level was positively correlated with the left atrial anteroposterior diameter ( r = 0.745), left atrial left and right diameter ( r = 0.759), left atrial upper and lower diameter ( r = 0.810), left atrial volume ( r = 0.837), left atrial volume index ( r = 0.813), and left atrial sphericity ( r = 0.785) but negatively correlated with the left atrial global ejection fraction ( r = ‐0.731) ( p &lt; 0.05).The expression level of serum mip‐1 α is high in atrial fibrillation patients and is associated with the risk of left atrial remodeling.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Clinical Study;
Magnetic Resonance Imaging Characteristic Evaluation of Dexmedetomidine on Neurocognitive Dysfunction in Elderly Patients with Colorectal Tumors after Laparoscopic Operation

In order to investigate the effects of dexmedetomidine (dex) on postoperative anesthesia recovery time and consciousness function in elderly patients with laparoscopic colorectal tumors, 40 patients (20 in the control group and 20 in the dex group) were selected.The dex group was intravenously pumped at a rate of 0.8 μg/kg/h for 10 min and then continuously pumped at a rate of 0.3 μg/kg/h until 40 min before the end of the operation.The two groups were given the same amount of normal saline, with the same way of anesthesia.The results showed that the visual analog scale (vas) score of pain in the two groups decreased signally.Compared with the control group, the inflammatory factors tumor necrosis factor (tnf-α), interleukin-1β (il-1β), interleukin-6 (il-6), and macrophage inflammatory protein (mip-2) in the dex group were remarkably decreased at t1 and t2 stages, with a considerable difference ( p &lt; 0.05 ).One month after the auxiliary diagnosis of colorectal tumor, no clear nodular, irregular shape patches, or patchy diffuse limited points were found, which indicated that the whole tumor had been removed.In summary, dex could improve postoperative cognitive function in elderly patients who underwent the laparoscopic radical resection of colon cancer, and its mechanism was related to the reduction of inflammatory factors.Therefore, the anesthesia intervention with dex during the operation had a positive significance for tumor resection.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;