syedzayyan/paper_mill_benchmark huggingface dataset:
A systematic review and Bayesian network meta-analysis for comparative safety assessment of favipiravir interventions in hospitalized COVID-19 patients.

Introduction covid-19 is a coronavirus-based infectious illness that was first detected at the end of 2019 in wuhan, china.The novel virus induces severe acute respiratory syndrome (sars-co v-2) and has spread globally, resulting in an ongoing pandemic.There is still a lack of evidence for direct comparison of favipiravir therapy.Network meta-analysis (nma), may incorporate direct and indirect comparisons in a pooled computation while depending on strong assumptions and premises.This study provides evidence-based recommendations on the safety of currently used clinical pharmacological treatments compared to favipiravir for covid-19 patients.Methodology we conducted a systematic review and bayesian nma.We searched the primary databases and clinical trials center for reports of short-term, randomized controlled trials (rcts) of favipiravir for covid-19 treatment.The primary endpoints here considered were any adverse events observed or reported during the treatment cycle with estimates of odds ratio (or) and 95% confidence interval (ci), until november 6, 2021.Results between january 2020 and july 2021, 908 individuals were randomly assigned to one of the seven active prescription medication regimens or placebo in this study, generating seven direct comparisons on 12 data points.The safety of favipiravir over the four clinically efficacious monotherapies or combinations including tocilizumab, arbidol, lopinavir + ritonavir, and chloroquine remained unknown due to the lack of a significant difference and the limited sample size.Conclusions overall, comparative rankings could assist doctors and guideline developers in decision-making.We have also concluded that the safety of favipiravir requires further attention.

Journal: Journal of infection in developing countries (2022)
Publication types: Journal Article;Meta-Analysis;Systematic Review;Research Support, Non-U.S. Gov't
The Use of SPME-GC-MS IR and Raman Techniques for Botanical and Geographical Authentication and Detection of Adulteration of Honey.

The aim of this review is to describe the chromatographic, spectrometric, and spectroscopic techniques applied to honey for the determination of botanical and geographical origin and detection of adulteration.Based on the volatile profile of honey and using solid phase microextraction-gas chromatography-mass spectrometry (spme-gc-ms) analytical technique, botanical and geographical characterization of honey can be successfully determined.In addition, the use of vibrational spectroscopic techniques, in particular, infrared (ir) and raman spectroscopy, are discussed as a tool for the detection of honey adulteration and verification of its botanical and geographical origin.Manipulation of the obtained data regarding all the above-mentioned techniques was performed using chemometric analysis.This article reviews the literature between 2007 and 2020.

Journal: Foods (Basel, Switzerland) (2021)
Publication types: Journal Article;Review
Europe's War against COVID-19: A Map of Countries' Disease Vulnerability Using Mortality Indicators.

Specific and older age-associated comorbidities increase mortality risk in severe forms of coronavirus disease (covid-19).We matched covid-19 comorbidities with causes of death in 28 eu countries for the total population and for the population above 65 years and applied a machine-learning-based tree clustering algorithm on shares of death for covid-19 comorbidities and for influenza and on their growth rates between 2011 and 2016.We distributed eu countries in clusters and drew a map of the eu populations' vulnerabilities to covid-19 comorbidities and to influenza.Noncommunicable diseases had impressive shares of death in the eu but with substantial differences between eastern and western countries.The tree clustering algorithm accurately indicated the presence of western and eastern country clusters, with significantly different patterns of disease shares of death and growth rates.Western populations displayed higher vulnerability to malignancy, blood-related diseases, and diabetes mellitus and lower respiratory diseases, while eastern countries' populations suffered more from ischaemic heart, cerebrovascular, and circulatory diseases.Dissimilarities between eu countries were also present when influenza was considered.The heat maps of eu populations' vulnerability to diseases based on mortality indicators constitute the basis for more targeted health policy strategies in a collaborative effort at the eu level.

Journal: International journal of environmental research and public health (2020)
Publication types: Journal Article
Sodium Hypochlorite and Diode Laser in Non-Surgical Treatment of Periodontitis: Clinical and Bacteriological Study with Real Time Polymerase Chain Reaction (PCR).

Increasing the disinfection during non-surgical treatment of periodontitis is primordial.This study assesses the effectiveness of sodium hypochlorite and a 980 nm diode laser in non-surgical treatment of periodontitis.Thirty sites of localized periodontitis with a probing pocket depth (ppd) of ≥ 6 mm were included.Fifteen underwent scaling root planing (srp group) and 15 underwent srp + 0.5% na ocl and a 980 nm diode laser (study group).A biological molecular test and real time polymerase chain reaction (rt-pcr) were performed before (t0) and after intervention (t1).Total bacterial count and counts of porphyromonas gingivalis, treponema denticola, tannerella forsythia, prevotella intermedia, peptostreptococcus micros, fusobacterium nucleatum, aggregatibacter actinomycetemcomitans, eubacterium nodatum, capnocytophaga gingivalis were assessed.Plaque index (pi), bleeding on probing (bop), gingival recession (gr), ppd and clinical attachment loss (cal) were evaluated at t0, and 3 and 6 months after.Study group showed a statistically significant reduction of tbc (5.66 × 108cfu/m l) compared to srp (6.2 × 109cfu/m l).Both groups showed a statistically significant reduction of treponema denticola, tannerella forsythia, prevotella intermedia, peptostrep.(micromonas) micros and fusobacterium nucleatum; however, a significant reduction of eubacterium nodatum and capnocytophaga gingivalis was observed in the study group.At t6, both groups had a statistically significant reduction of pi, bop, gr, pd and cal.The study group showed more gr compared to srp and a significant reduction of pd (4.03 mm ± 0.49) compared to srp (5.28 mm ± 0.67).This study reveals that na ocl and a diode laser are effective as an adjunctive to the non-surgical treatment of periodontitis.

Journal: Life (Basel, Switzerland) (2022)
Publication types: Journal Article
Controlled-Potential-Based Electrochemical Sulfide Sensors: A Review.

Due to their potential applications in industry and potent toxicity to the environment, sulfides and their detection have attracted the attention of researchers.To date, a large number of controlled-potential techniques for electrochemical sulfide sensors have been developed, thanks to their simplicity, reasonable limit of detection (lod), and good selectivity.Different researchers have applied different strategies for developing selective and sensitive sulfide sensors.However, there has been no systematic review on controlled-potential techniques for sulfide sensing.In light of this absence, the main aim of this review article is to summarize various strategies for detecting sulfide in different media.The efficiencies of the developed sulfide sensors for detecting sulfide in its various forms are determined, and the essential parameters, including sensing strategies, working electrodes, detection media, p h, lod, sensitivity, and linear detection range, are emphasized in particular.Future research in this area is also recommended.It is expected that this review will act as a basis for further research on the fabrication of sulfide sensors for practical applications.

Journal: Chemical record (New York, N.Y.) (2021)
Publication types: Journal Article;Review
Risk factors of geriatric depression among elderly Bangladeshi people: A pilot interview study.

Globally, geriatric depression (gd) has been recognized to be one of the most prevalent problems among the elderly.However, there is an only one previous bangladeshi study addressing the issue.Consequently, the present study investigated gd and its associated risk factors.A semi-structured face-to-face interview was conducted among 168 self-reported healthy elderly residents (59.5% female) aged 60-80 years in patuakhali city and the neighboring village.Measures included the geriatric depression scale-15, socio-demographic variables, psychosocial factors, physical health-related factors, lifestyle factors, and dietary factors.Results showed the gd prevalence rate was 36.9% (n = 62).Risk factors for gd included living in a rural area, having no history of chronic disease, having a history of previous personal and/or family depression, not engaging in daily life activities, not exercising regularly, having no hobbies, having a poor diet, and not engaging in religious practices regularly.The gd prevalence rate was generally higher compared to previous studies in other countries.This may have been due to the inclusion criterion of selecting self-reported healthy elderly individuals.It is recommended that a nationally representative study is carried out to assess the actual figure of gd in bangladesh.The findings are helpful for depression-reducing intervention programs.

Journal: Asian journal of psychiatry (2019)
Publication types: Journal Article
Implantation of bovine hydroxyapatite and secretome with different oxygen concentration may improve massive bone defect regeneration: An experimental study on animal model.

The most widely used biomaterials in the treatment of massive bone defects are allograft bone or metal implants.The current problem is that the availability of allographs is limited and metal implants are very expensive.Mass production of secretome can make bone reconstruction of massive bone defects using a scaffold more effective and efficient.This study aims to prove bone regeneration in massive bone defects using bovine hydroxyapatite reconstruction with normoxic and hypoxic secretome conditions using collagen type 1 (col1), alkaline phosphate (alp), osteonectin (on), and osteopontin (opn) parameters.This is an in vivo study using male new zealand white rabbits aged 6-9 months.The research was carried out at the biomaterials center-tissue bank, dr.Soetomo hospital for the manufacturer of bovine hydroxyapatite (bha) and secretome bm-msc culture under normoxic and hypoxic conditions, and unair tropical disease institute for implantation in experimental animals.Data analysis was carried out with the one-way anova statistical test and continued with the post hoc test lsd statistical test to determine whether or not there were significant differences between groups.There were significant differences between hypoxic to normoxic group and hypoxic to bha group at day-30 observation using alp, col 1, on, and opn parameters.Meanwhile, there is only osteonectin parameter has significant difference at day-30 observation.At day-60 observation, only opn parameter has significant differences between hypoxic to normoxic and hypoxic to bha group.Between day-30 and day-60 observation, bha and normoxic groups have a significant difference at all parameters, but in hypoxic group, there are only difference at alp, col 1, and on parameters.Hypoxic condition bm-msc secretome with bha composite is superior and could be an option for treating bone defect.

Journal: Journal of biomaterials applications (2022)
Publication types: Journal Article
Promising strategies to control persistent enemies: Some new technologies to combat biofilm in the food industry-A review.

Biofilm is an advanced form of protection that allows bacterial cells to withstand adverse environmental conditions.The complex structure of biofilm results from genetic-related mechanisms besides other factors such as bacterial morphology or substratum properties.Inhibition of biofilm formation of harmful bacteria (spoilage and pathogenic bacteria) is a critical task in the food industry because of the enhanced resistance of biofilm bacteria to stress, such as cleaning and disinfection methods traditionally used in food processing plants, and the increased food safety risks threatening consumer health caused by recurrent contamination and rapid deterioration of food by biofilm cells.Therefore, it is urgent to find methods and strategies for effectively combating bacterial biofilm formation and eradicating mature biofilms.Innovative and promising approaches to control bacteria and their biofilms are emerging.These new approaches range from methods based on natural ingredients to the use of nanoparticles.This literature review aims to describe the efficacy of these strategies and provide an overview of recent promising biofilm control technologies in the food processing sector.

Journal: Comprehensive reviews in food science and food safety (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Adolescent social media use and its association with relationships and connections: Canadian Health Behaviour in School-aged Children, 2017/2018.

The development of healthy relationships and connections is of fundamental importance to adolescent well-being.The use of social media plays a vital role in the lives of young canadians, yet the association between different types of social media use and the quality of relationships and connections remains unknown, and most existing analyses on this topic are based on modest and non-representative samples.Data and methods using 2017/2018 reports from the nationally representative health behaviour in school-aged children study (n=17,149; ages 11 to 15 years), the strength, consistency and significance of associations was examined between intensive (frequent use to connect with other people) and problematic (use that depicts addictive qualities) social media use and available measures of adolescent relationships and connections.Results overall, intensive use (online communication with others almost all of the time) and problematic use (potential addiction to social media) were more common in girls than boys (38% of girls versus 30% of boys and 7.7% of girls versus 5.2% of boys, respectively), with prevalence levels that rose with age.Intensive use was associated with more positive social relationships with friends, especially among girls (relative risk [rr] = 1.40 [95% confidence interval (ci) 1.28 - 1.54]), while problematic use was consistently and negatively associated with strong relationships and connections in all groups in the study.Notably, problematic use was negatively associated with strong family relationships in boys (rr = 0.58 [95% ci 0.42 to 0.79]) and girls (rr=0.48 [95% ci 0.36 to 0.63]).Interpretation intensive use of social media has the potential to strengthen relationships and connections in adolescents.However, when social media use becomes addictive or "problematic", it is highly correlated with weaker relationships and a sense of social disconnection.Public health initiatives related to social media use should consider how different types of social media use have the potential to impact on different aspects of health.

Journal: Health reports (2022)
Publication types: Journal Article
Multi-sample measurement of hyperpolarized pyruvate-to-lactate flux in melanoma cells.

Hyperpolarized [1-13c] pyruvate can be used to examine the metabolic state of cancer cells, highlighting a key metabolic characteristic of cancer: the upregulated metabolic flux to lactate, even in the presence of oxygen (warburg effect).Thus, the rate constant of13c exchange of pyruvate to lactate, k pl, can serve as a metabolic biomarker of cancer presence, aggressiveness and therapy response.Established in vitro hyperpolarized experiments dissolve the probe for each cell sample independently, an inefficient process that consumes excessive time and resources.Expanding on our previous development of a microcoil with greatly increased detection sensitivity (103-fold) compared with traditional in vitro methods, we present a novel microcoil equipped with a 10-μl vertical reservoir and an experimental protocol utilizing deuterated dissolution buffer to measure metabolic flux in multiple mass-limited cell suspension samples using a single dissolution.This method increases efficiency and potentially reduces the methodological variability associated with hyperpolarized experiments.This technique was used to measure pyruvate-to-lactate flux in melanoma cells to assess braf-inhibition treatment response.There was a significant reduction of k plin brafv600ecells following 24 and 48 hours of treatment with 2 μm vemurafenib (p ≤ .05).This agrees with significant changes observed in the pool sizes of extracellular lactate (p ≤ .05) and glucose (p ≤ .001) following 6 and 48 hours of treatment, respectively, and a significant reduction in cell proliferation following 72 hours of treatment (p ≤ .01).Braf inhibition had no significant effect on the metabolic flux of brafwtcells.These data demonstrate a 6-8-fold increase in efficiency for the measurement of k plin cell suspension samples compared with traditional hyperpolarized in vitro methods.

Journal: NMR in biomedicine (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
The Law of Minimum Vertical Dimension: Evidence for Improvement of Dental Occlusion.

The law of minimum vertical dimension (mvd) states that "when the mandible moves to reach the maximum intercuspal position, this always involves bringing the mandible and maxilla as close together as possible." therefore, after the first occlusal contact is made, the mip will be reached through reduction of the vertical dimension.Our objective of this study, through an integrative review of the literature review, was to determine whether ignoring this law is a factor that contributes to malocclusion, temporomandibular joint dysfunction, and recurrences of functional orthodontic and orthopedic treatments.we conducted a search of the literature in five of the main electronic scientific databases.The following medical subject heading terms were used in our search: centric relation, dental occlusion, malocclusion, vertical dimension, and mastication.We cross-referenced the descriptors in the following four groups: centric relation and maximum intercuspation; occlusal plane and malocclusion; neuro-occlusal rehabilitation; and vertical dimension and unilateral chewing.From this, we selected 277 potentially eligible articles.Out of these, 209 were excluded in accordance with the exclusion criteria already described.Thus, 65 studies were included in the qualitative synthesis.the articles were also classified according to their impact factor and degree of recommendation, in conformity with the table of the oxford centre for evidence-based medicine.The scientific interest in the scope of the articles was also assessed by using three charts developed according to year and country of publication and the percentage of publication.Unilateral chewing creates a vicious cycle of damage that leads to an ever-increasing masticatory deficiency.Most of the articles chosen for this review confirmed that noncompliance with law of mvd was a predisposing factor in cases of relapse, in functional orthodontic and orthopedic treatments, as well as a causal factor in malocclusion and in functional and morphological tmj dysfunctions.

Journal: European journal of dentistry (2022)
Publication types: Journal Article
Assessing serial dependence in ordinal patterns processes using chi-squared tests with application to EEG data analysis.

We extend elsinger's work on chi-squared tests for independence using ordinal patterns and investigate the general class of m-dependent ordinal patterns processes, to which belong ordinal patterns processes derived from random walk, white noise, and moving average processes.We describe chi-squared asymptotically distributed statistics for such processes that take into account necessary constraints on ordinal patterns probabilities and propose a test for m-dependence, with which we are able to quantify the range of serial dependence in a process.We apply the test to epilepsy electroencephalography time series data and observe shorter m-dependence associated with seizures, suggesting that the range of serial dependence decreases during those events.

Journal: Chaos (Woodbury, N.Y.) (2022)
Publication types: Journal Article
The Impact of the COVID-19 Lockdown on the Quality of Life in Chronic Neurological Diseases: The Results of a COVQoL-CND Study.

Coronavirus disease 2019 (covid-19) pandemic and lockdown period may induce an impairment in quality of life (qo l), disruption in treatment (dit), and posttraumatic stress disorder (ptsd) in chronic neurological diseases (cnds).To reach this information, a multicenter, cross-sectional study (covqo l-cnd) was planned.Parkinson's disease (pd), headache (ha), multiple sclerosis (ms), epilepsy (ep), polyneuropathy (pnp), and cerebrovascular disease (cvd) were selected as the cnd.Methods the covqo l-cnd study includes demographic data, the world health organization quality of life short form (whoqol-bref), and impact of event scale-revised (ies-r) forms.Results the mean age of a total of 577 patients was 49 ± 17 (19-87 years), and the ratio of female/male was 352/225.The mean age of patients with pd, ha, ms, ep, pnp, and cvd were 65 ± 11, 39 ± 12, 38 ± 10, 47 ± 17, 61 ± 12, and 60 ± 15 years, respectively.The ies-r scores were found to be higher in the younger group, those with comorbid disease, contacted with co-vid-19 patients, or diagnosed with covid-19.In the group with a high ies-r score, the rate of dit was found to be high.Ies-r scores were negatively correlated with qo l.Ies-r total scores were found highest in the cvd group and lowest in the pd group.The ratio of dit was found highest in the pnp group and the lowest in the ep group.Contact with co-vid-19 patients was high in the ep and ha group.Conclusions the results of the covqo l-cnd study showed that lockdown causes posttraumatic stress and deterioration in the qo l in cnd.

Journal: European neurology (2021)
Publication types: Journal Article;Multicenter Study
Profiling Transcriptomes of Manually Dissected Arabidopsis Embryos.

Genome-wide characterization of rna populations in early flowering plant embryos can yield insights into the gene regulatory processes functioning during this formative phase of development.However, early embryonic transcriptomes are technically challenging to profile because of the low amount of rna obtainable and potential rna contamination from surrounding nonembryonic tissues.Here we provide a detailed protocol for collecting early arabidopsis thaliana (arabidopsis) embryos, generating m rna sequencing (m rna-seq) libraries, and basic data processing and quality controls of the resulting m rna-seq data.

Journal: Methods in molecular biology (Clifton, N.J.) (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't