syedzayyan/paper_mill_benchmark huggingface dataset:
The Effects of Elgucare on Degenerated Intervertebral Disc-Induced Low Back Pain and Disc Regeneration: A Clinical Trial

Introduction.Chronic low back pain (lbp) has a wide range of causes.However, most cases are induced by degeneration of the lumbar intervertebral discs (ivds), and the aching caused by local compression of the affected region has considerable impacts on quality of life.This clinical trial investigated the use of elgucare, a chinese herbal formula, as a food supplement to reduce the pain of patients with lbp induced by degeneration of the lumbar ivds.Methods.The study assessed patient subjective quality of life, functional limitations caused by lbp, and variations in pain.The assessment was done through the visual analogue scale (vas) and effects on lumbar ivd thickness, water content, and bone mineral density (bmd).These parameters were evaluated before and after the administration of elgucare or a placebo, one of which was taken by each participant for a 12-month period.Results.Elgucare reduced the patients’ mean vas pain score by 2.25 points and improved their mean lbp-hampered mobility as assessed by the roland-morris questionnaire by 5.17 points.The results of another questionnaire indicated that elgucare slowed the lbp-induced deterioration of patients’ quality of life, while objective assessment indices obtained through x-ray and magnetic resonance imaging showed that the height and water retention of their ivds were increased.However, the bmd results showed no improvements.Conclusions.Elgucare can increase the water retention and height of ivds and reduce lbp, thereby enhancing quality of life.Therefore, elgucare can potentially be used as a clinical supplement.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Clinical Study;
The Effect of Needle Tract Nursing Methods to Reduce Needle Tract Infection in Patients with Indwelling Percutaneous Bone Puncture

Percutaneous bone piercing needles are used in orthopedics, which play the role of needle fixation.Needle tract infection is a common complication during the use of percutaneous bone needles.How to prevent needle tract infection is an important topic, so it is necessary to explore better needle tract care methods during percutaneous bone needle indwelling, to provide a basis for clinical work.Based on this, the purpose of this article is to study the effects of needle tract nursing methods for patients with indwelling percutaneous bone puncture needle infections.In this article, through an overview of percutaneous bone needle tract infection, on this basis, a detailed analysis of its occurrence, causes, and main influencing factors are carried out.Experimental studies have shown that the incidence of needle tract infections is 23.64%, mainly mild needle tract infections.Mild needle tract infections account for 84.62% of all needle tract infections, of which grade 1 needle tract infections account for 50.00 of mild needle tract infections.Severe needle tract infections accounted for 15.38% of all needle tract infections.All severe needle tract infections were grade 4 needle tract infections.No patients had bone infections or osteomyelitis.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Clinical Study;
The Effect of miR-138 on the Function of Follicular Helper T Cells and the Differentiation of B Cells in Osteosarcoma

To explore the effect of mi r-138 on the function of follicular helper t (tfh) cells and the differentiation of b cells in osteosarcoma.Methods.Clinically collect peripheral blood from osteosarcoma (os) patients and healthy volunteers (hc), as well as os tumor tissues (os tumor) and adjacent tissues with normal histology (normal group).The cd4+cxcr5+tfh cells of os patients were screened and isolated by flow cytometry, and the expression of tfh cell membrane surface antigens pd-1 and ctla-4 was detected.In addition, q rt-pcr was used to detect the expression of mi r-138 in tissues and tfh cells, and the correlation relationship between mi r-138 and pd-1 and ctla-4 was analyzed.After interference or overexpression of mi r-138 in tfh cells, coculture with untreated b cells was done, and the levels of il-10, il-12, il-21, and inf-γ in tfh cell culture medium and the levels of ig m, ig g, and ig a in b cell culture medium after coculture were measured by elisa.Flow cytometry was used to detect the expression of b cell membrane surface antigens cd27 and cd38 after coculture.Results.The rate of pd-1- and ctla-4 positive cells in the peripheral blood and tissues of the os group was significantly increased, the expression of mi r-138 was significantly reduced, and the expression of mi r-138 was negatively correlated with the expression of pd-1 and ctla-4.In addition, upregulation of mi r-138 can lead to a significant increase in the level of il-10 in the supernatant of tfh cells and a significant decrease in the levels of il-12, il-21, and inf-γ, which in turn leads to increased levels of ig m, ig g, and ig a released by b cells.At the same time, it significantly increases the rate of cd27- and cd38-positive cells and promotes the maturation of b cells.Downregulating mi r-138 has the opposite effect.Conclusion.Downregulating the expression of mi r-138 in osteosarcoma can improve the dysfunction of cd4+cxcr5+tfh cells and promote the differentiation of b cells.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
The Effect of Different Treatment Methods on Acute Acquired Concomitant Esotropia

The application of botulinum toxin type a (btxa) in the treatment of paralytic strabismus has been recognized, but there are few studies on the treatment of acute acquired comitant esotropia (aace).This study was aimed to investigate the clinical characteristics of aace and compare the therapeutic effects of btxa and traditional surgery.Methods.78 patients with aace in renmin hospital of wuhan university between march 2019 and march 2021 were reviewed.The relevant medical records of the patients were collected, and they were divided into surgical group ( n = 46 ) and botulinum toxin type a (btxa) group ( n = 32 ) according to different treatment approaches.The surgical group was treated with squint correction, whereas the btxa group was treated with microinjection of btxa in mr.Eye alignment, esotropia, stereopsis, and complications were examined before and after treatment in both groups.Results.The refractive status of 78 patients with aace was mostly myopic refractive error.In general, the angle of esotropia at distance was larger than which at near, with a statistically significant difference.At follow-up assessments of 1 week, 1 month, 3 months, and 6 months after treatment, the total effective rates of the surgical group and the btxa group were 100% and 90.48%, respectively.The residual angle of esotropia of both groups was lower after treatment.Additionally, the incidence rate of complications in the btxa group was significantly lower than that in the surgical group.Conclusion.Aace occurs mostly in people with myopic refractive errors and is associated with prolonged near work.Besides surgical treatment, micro-injection of btxa is also an effective and safe treatment for aace.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
The Effect of Chia Seed Extracts against Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis in Rats

And objectives.It is known that the oxidation of chia seeds is minimal or absent, due to the presence of bioactive compounds, having a great potential in the foods and pharmacological industry.This investigation was done to estimate the nutrition values and anti-oxidant activity of chia seed extracts.Materials and methods.The protective effects of chia seed extract against complete freund’s adjuvant (cfa) rheumatoid arthritis in rats were investigated with 100, 200, 300, and 400 ppm/kg bw rat/day chia seeds aqueous extract for 4 weeks.Results.The results obtained revealed that chia seed extract contained high proportions of protein and total dietary fiber values of 21.35% and 27.24%, respectively.Moreover, the results reported that the mineral contents were the greatest in phosphorous, potassium, magnesium, calcium, and sodium (450.09, 410.46, 245.22, 218.69, and 120.34 mg/100 g, respectively).Meanwhile, iron, zinc, and copper were the lowest in chia seeds (9.26, 4.67, and 3.66 mg/100 g, respectively).Besides, vitamins c and e reported 1.65 and 0.82 mg/100 g, respectively.Chia seed extracts were effective in vitro for the bioactive components such as phenolics, flavonoids, and anti-oxidant activities.The biomarkers of complete blood picture, lipid profile, anti-oxidant enzymes, tnf-α, and il-10 had been improved.Histopathological examination of the rat knee confirmed health amelioration, revealing that chia seed extract consumption can lower pathological changes in injured rheumatoid arthritis rats.Conclusion.It could be seen that the chia seed extracts alleviated the harmful effect of rheumatoid arthritis cfa-induced rats.

Journal: Journal of Food Quality (2022)
Publication types: Research Article;
The Dynamic Movement of Disaster Management Systems Based on Vehicle Networks and Applied on the Healthcare System

In order to save human life and assets, the emergency management system (dms) requires roving rescue teams to respond promptly and effectively.Installation and restoration of appropriate communication infrastructure are important for reducing the effect of disasters and enabling and coordinating information flow among relief teams working in the region.This paper describes a data collection system based on vehicular cloud network services that incorporates the advantages of both architectures of vehicular ad hoc networks (vanets) with the cloud to establish vehicular cloud networks (vcns).Vehicles in the current plan perform tasks like monitoring the environment, gathering data, and transmitting data to the control center depending on their positions and instructions.To build a disaster management system, the proposed system uses hybrid wireless networking, which includes both a central system and ad hoc networks.The implementation results show that the suggested system is more dependable and efficient; even light density is improved in terms of reachability with few hops.Furthermore, as compared to the existing system, the suggested system has a lower end-to-end delay and a higher packet delivery ratio.

Journal: Applied Bionics and Biomechanics (2021)
Publication types: Research Article;
The Determination of Efficacy of CircuCare on Blood Circulation and Metabolism: An Animal Model Study

S.To determine whether feeding circu care to rats improves blood circulation, metabolism, immune regulation, endocrine activity, and oxidative stress.Methods.28 eight-week-old male sprague-dawley rats were evenly randomized into control and experimental groups.The control group was fed with ordinary drinking water, while the experimental group was fed with circu care at a daily dose of 93.75 mg per 300 g of body weight over eight weeks.Both groups were subjected to a swimming test, and blood samples were taken to observe any variations in various biochemical parameters before and after the test.Key findings.The experimental group’s mean swimming exhaustion duration was 53.2% longer and had a significantly higher lactic acid removal ratio.Their mean prostaglandin e2 level and mean glucose, cortisol, and glutathione level (30 minutes after swimming test) were also significantly higher.No undesirable impacts from circu care relating to general blood biochemistry values and bone mineral density were reported.Conclusions.The present results show that circu care can be safely used to increase stamina and exercise capability, expedite the metabolism of lactic acid, accelerate muscle repair, and promote the antioxidant activity of cells in rats.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
The Curative Effect of Shuangshen Decoction Combined with Immunological Preparations in the Treatment of Pediatric Nephrotic Syndrome and Its Influence on the Rate of Complicated Infection and Recurrence

To explore the curative effect of shuangshen decoction combined with immunological preparations in the treatment of pediatric nephrotic syndrome and its influence on concurrent infection and recurrence rate.Methods.Ninety children with nephrotic syndrome were divided into the routine group and the combined group.The routine group received conventional treatment and immune agents, and the combined group was treated with shuangshen decoction on the basis of the routine group.The clinical indexes of the two groups were analyzed and followed up.The infection rate and recurrence rate were calculated.Results.The tcm syndrome scores in the combined group were significantly lower than those in the routine group.The total effective rate of the combined group was significantly higher than that of the routine group.The recurrence rate and infection rate of the combined group were significantly lower than those of the routine group.The incidence of adverse reactions in the combined group was significantly lower than that in the routine group.Conclusion.Shuangshen decoction combined with immune preparations is effective in treating pediatric nephrotic syndrome and can reduce the incidence of adverse reactions, infection rate, and recurrence rate.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
The Construction of Virtual Experiment Platform Based on the Fuzzy System

Virtual experiment platform is an open network virtual experiment system, and it is constructed by virtual reality technology.It virtualizes and digitizes experimental resources in the current virtual experiment platform.Virtual experimental platform is similar to real experimental platform.Users can adjust the virtual instrument to complete the experiment process.In this paper, a virtual experiment platform model of the fuzzy system is built.Based on the acquired correlative variables of the fuzzy system, a virtual experiment platform model of the fuzzy system based on the recursive fuzzy network is established.And the model is trained and modified by using the running data of the actual fuzzy algorithm, and the prediction of the fuzzy system in the process of virtual experiment platform is realized.The experimental results show that the virtual experiment platform model of the fuzzy system based on the recursive fuzzy neural network can obtain higher prediction accuracy.Compared with standard fuzzy neural network and other modeling methods, the model of virtual experiment platform of the fuzzy system proposed in this paper can obtain better prediction effect.So, the virtual experiment platform based on the fuzzy algorithm is feasible.The virtual experiment simulation platform of the fuzzy system is built, and the experiment design and research are carried out through the virtual experiment simulation platform.

Journal: Wireless Communications and Mobile Computing (2022)
Publication types: Research Article;
Task-Oriented Intelligent Solution to Measure Parkinson’s Disease Tremor Severity

Tremor is a common symptom of parkinson’s disease (pd).Currently, tremor is evaluated clinically based on mds-updrs rating scale, which is inaccurate, subjective, and unreliable.Precise assessment of tremor severity is the key to effective treatment to alleviate the symptom.Therefore, several objective methods have been proposed for measuring and quantifying pd tremor from data collected while patients performing scripted and unscripted tasks.However, up to now, the literature appears to focus on suggesting tremor severity classification methods without discrimination tasks effect on classification and tremor severity measurement.In this study, a novel approach to identify a recommended system is used to measure tremor severity, including the influence of tasks performed during data collection on classification performance.The recommended system comprises recommended tasks, classifier, classifier hyperparameters, and resampling technique.The proposed approach is based on the above-average rule of five advanced metrics results of four subdatasets, six resampling techniques, six classifiers besides signal processing, and features extraction techniques.The results of this study indicate that tasks that do not involve direct wrist movements are better than tasks that involve direct wrist movements for tremor severity measurements.Furthermore, resampling techniques improve classification performance significantly.The findings of this study suggest that a recommended system consists of support vector machine (svm) classifier combined with borderline smote oversampling technique and data collection while performing set of recommended tasks, which are sitting, stairs up and down, walking straight, walking while counting, and standing.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Study on the Mechanism of miR-34a Affecting the Proliferation, Migration, and Invasion of Human Keloid Fibroblasts by Regulating the Expression of SATB1

S.To explore the effect and mechanism of mi r-34a on the proliferation, migration, and invasion of keloid fibroblasts (kfb).Methods.Isolate and culture kfb and normal skin fibroblast (nfb), detect the m rna expression levels of mi r-34a and integrin β5 (satb1) in kfb and nfb by rt-q pcr, and detect satb1 by western blot.The level of protein expression, mtt method, transwell method, rt-q pcr, and western blot were used to detect the effects of overexpression of mi r-34a or inhibition of satb1 expression on the proliferation, migration, and invasion of kfb cells and the expression of related proteins.The dual luciferase reporter gene test verifies the targeting relationship between mi r-34a and satb1.Results.Compared with nfb, the expression of mi r-34a was downregulated in kfb and the m rna and protein expression levels of satb1 were upregulated.Overexpression of mi r-34a or inhibition of satb1 expression inhibited the proliferation, migration, and invasion of kfb.Mi r-34a can negatively regulate the expression of satb1, and overexpression of satb1 reverses the effects of overexpression of mi r-34a on the proliferation, migration, and invasion of kfb.Conclusions.Mi r-34a inhibits the proliferation, migration, and invasion of keloid fibroblasts by downregulating the expression of satb1.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer

Doxorubicin (dox) has been widely recognized as effective in anticancer therapy; however, the additional organ toxicity and low targeting of dox in antitumor activity remains unaddressed.The aim of this study was to use the drug carrier dextran/polylactic acid (dex/pla) and paramagnetic fe3o4 to improve the targeting of dox in liver cancer treatment while reducing its potential organ toxicity.Our experimental results show that the combination drug (fe3o4@dex/pla-dox) exhibits strong hepatocarcinogenic inhibition and low cytotoxicity and that this modified drug provides a better option for clinical liver cancer treatment.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Study on Algorithm of Statistical Model for Improving Core Competitiveness of Manufacturing Industry Based on Digital Information Technology

The aim is to improve the core competitiveness of china’s manufacturing industry, promote the development of digital information technology, break through the difficulties brought by china’s manufacturing industry to the high end, and enhance china’s international influence and comprehensive competitiveness.Method.The construction of the statistical algorithm model of the core competitiveness of the manufacturing industry is improved by using the statistical algorithm of the key points of the core competitiveness of the manufacturing industry.Different comparisons are made between the two groups of algorithms, such as comparing the core competitiveness evaluation results of different types of manufacturing industry and the coupling degree of core competitiveness, statistical model, and economic growth trend of manufacturing industry.The research results show that, under the control of digital information technology, the overall coupling degree of the statistical model is rising and has an obvious increase on the manufacturing economy.We promote the deep integration of digital information, artificial intelligence, and the real economy; realize the industrialization of key technologies in the manufacturing industry; and enhance the core competitiveness of the manufacturing industry.Driven by digital information, china’s manufacturing industry will enter the high-speed development lane, so as to promote the high-quality development of china’s manufacturing industry.It has provided a solid foundation for ensuring the steady and healthy development of people’s economy and promoted the transformation of china from a large manufacturing country to a powerful manufacturing country and from “made in china” to “created in china.”

Journal: Mobile Information Systems (2022)
Publication types: Research Article;
Stakeholders’ Viewpoints toward Blockchain Integration within IoT-Based Smart Cities

This study intends to assess the development of io t‐based smart cities industry and the possibilities of blockchain integration from the perspective of industry stakeholders as the vision for a modern, integrated smart city future is predicated upon intelligence and the relationship between data‐rich connections and human activities.Although this ideal of an interconnected urban landscape is currently being tested and actively used by consumers spanning a range of connected nodes and service solutions, the scalability, interoperability, and security of this emergent cyber‐physical ideal has yet to be adequately resolved.This study used an exploratory study design following a mixed method design approach.A structured questionnaire survey (quantitative) and interviews (qualitative) were conducted for collecting data.Ibm spss was used for the analysis of the data, which computed descriptive statistics, cross‐tabulation, pearson correlation, and anova for quantitative data and thematic analysis for qualitative data.Through an empirical assessment of the perceptions and expertise of 122 stakeholders from within the worldwide io t smart city industry, conceptual support for blockchain integration into the io t solution was acquired, highlighting the solution‐oriented, system‐centered advantages of a decentralised, autonomous data management backbone that could be applied to future io t‐based smart city solutions.To meet the broad and diversified needs of the smart city and its future evolution, this study has confirmed that a commitment to decentralisation and blockchain intermediary data management is critical to scalable, secure, and autonomous negotiations of the io t‐enabled smart city networks.

Journal: Journal of Sensors (2021)
Publication types: Research Article;