syedzayyan/paper_mill_benchmark huggingface dataset:
20 pack-year smoking history as strongest smoking metric predictive of HPV-positive oropharyngeal cancer outcomes.

S while smoking is associated with worse outcomes in hpv-positive oropharyngeal squamous cell carcinoma (opscc), the magnitude of this association is unclear given the heterogenous smoking definitions and outcomes.Our objective was to investigate the association between smoking, survival, and recurrence in hpv-related opscc using multiple smoking metrics reported in the literature.Materials and methods this was a retrospective cohort study of 375 adults with p16+ opscc undergoing surgical resection (n = 272) or definitive chemoradiation (n = 103) at a tertiary academic institution from 2006 to 2017.The primary outcome was overall survival (os).Secondary outcomes included disease-free survival (dfs), disease-specific survival (dss), and recurrence.We used multiple smoking metrics commonly cited in previous studies, including ever versus never smokers, current versus former/never smokers, ≤10 versus >10 pack-year, ≤20 versus >20 pack-year, and continuous pack-year.Results there were 375 patients, median age 58 years, with 326 (87%) males, and median follow-up of 52 months.Of all smoking metrics, >20 pack-year history was the strongest predictor of both os (hr 2.24, 95% ci: 1.19-4.20) and dfs (hr 1.67, 95% ci: 1.04-2.66) on univariable and multivariable analysis after adjusting for age, overall stage, and comorbidities.Patients with >20 pack-year smoking history were also more likely to have recurrence (hr 1.59, 95% ci: 0.95-2.67) after adjusting for overall stage.Conclusion heavier smoking >20 pack-years was the strongest smoking metric associated with 2-times worse survival and recurrence.Our findings suggest that >20 pack-year smoking history may be a more useful cutoff for risk stratification models but requires further validation.

Journal: American journal of otolaryngology (2021)
Publication types: Journal Article
The Effect of Different Soft Core/Hard Shell Ratios on the Coating Performance of Acrylic Copolymer Latexes.

Core-shell acrylic copolymer latexes containing bio resourced itaconic acid with different compositions in respect with the core and shell segments were synthesized, characterized, and applied as coating materials for leather.The purpose of the study was to evidence the high coating performance of the latexes when the ratio of the core/shell differed from 90/10 to 50/50 wt %.The copolymers were prepared via emulsion copolymerization technique and the products were isolated and characterized by means of structure identity, thermal behavior (dsc and dmta), coating performance.The particle size of the latexes varied from 83 to 173 nm with the variation of the ratio of core/shell segments.The influence of the composition of soft part and hard part was highlighted in the thermal and coating properties.The optimal composition giving the best coating performance could be determined as ds 60/40.Further increase of the hard segment content, resulted in decreased emulsion stability and the coating performance on the leathers.The use of itaconic acid seemed to increase the emulsion stability as well the adhesion of the latexes to the substrate.

Journal: Polymers (2021)
Publication types: Journal Article
Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives.

Undertaking randomized clinical trials (rcts) in emergency surgical settings is associated with methodological and practical challenges.This study explored patients' and clinicians' perspectives associated with the conduct of an rct comparing laparoscopic and open colorectal surgery in the acute setting.Methods all eligible patients screened and enrolled for the 'laparoscopic versus open colorectal surgery in the acute setting (la ce s)' multicentre, randomized clinical feasibility trial in five uk nhs trusts were invited to respond to a survey.Patients and healthcare professionals were also invited to take part in semi-structured interviews.Survey and interviews explored the acceptability of the feasibility trial.Interviews were audio recorded, transcribed verbatim, and analysed using thematic analysis.Survey data were analysed descriptively to assess patient views of the trial and intervention.Results out of 72 patients enrolled for the la ce s rct, survey data were collected from 28 patients (38.9 per cent), and interviews were conducted with 16 patients and 14 healthcare professionals.Thirteen out of 28 patients (46 per cent) had treatment preferences but these were not strong enough to deter participation.Twelve of the patients interviewed believed that their surgeon preferred laparoscopic surgery, but this did not deter them from participating in the trial.Half of the surgeons interviewed expressed the view that laparoscopic surgery was of benefit in this setting, but recognized that the need for research evidence outweighed their personal treatment preferences.Eight of the 14 recruiters reported that the emergency setting affected recruitment, especially in centres with fewer recruiting surgeons.Interviewees reported that recruitment was helped significantly by using surgical trainees to consent patients.Conclusion this study identified specific challenges for the la ce s trial design to address and adds significant insights to our understanding of recruiting to emergency surgical trials more broadly.

Journal: BJS open (2022)
Publication types: Randomized Controlled Trial;Multicenter Study;Journal Article;Research Support, Non-U.S. Gov't
Phylogenetic and genomic analyses of two new species ofClavispora(Metschnikowiaceae,Saccharomycetales) from Central China.

Species in the genus clavisporahave previously been reported primarily in the northeast and northwest regions of china; the species diversity of clavisporain central china is not currently clear.In this study, phylogenetic inferences of clavisporabased on sequences of a single-locus (lsu d1/d2) and a two-locus (lsu d1/d2 and its) were conducted.Two new species isolated from rotting wood in central china, namely clavispora xylosasp.Nov.And clavispora paralusitaniaesp.Nov., were delimited and proposed based on morphological and molecular evidence.cl.Xylosawas closely related to c.Thailandica cbs 10610t, but with 11.5% divergence in the lsu d1/d2 domains and 11.5% divergence in the its regions.cl.Paralusitaniaewas a sister to cl.Lusitaniae cbs 6936tfrom which it differs with 4.7% divergence in the lsu d1/d2 domains and 5.4% divergence in the its regions.Description of cl.Xylosasp.Nov.And cl.Paralusitaniaesp.Nov.Was also supported by morphological comparisons and genomic analyses between the two new species and their closest relatives,c.Thailandica cbs 10610tand cl.Lusitaniae cbs 6936t.These results indicate a potentially great diversity of clavisporaspp.Inhabiting rotting wood in central china, ripe for future discovery.

Journal: Frontiers in microbiology (2022)
Publication types: Journal Article
Fibre-Reinforced Geopolymer Concretes for Sensible Heat Thermal Energy Storage: Simulations and Environmental Impact.

Power plants based on solar energy are spreading to accomplish the incoming green energy transition.Besides, affordable high-temperature sensible heat thermal energy storage (shtes) is required.In this work, the temperature distribution and thermal performance of novel solid media for shtes are investigated by finite element method (fem) modelling.A geopolymer, with/without fibre reinforcement, is simulated during a transient charging/discharging cycle.A life cycle assessment (lca) analysis is also carried out to investigate the environmental impact and sustainability of the proposed materials, analysing the embodied energy, the transport, and the production process.A multi-criteria decision making (mcdm) with the analytical hierarchy process (ahp) approach, taking into account thermal/environmental performance, is used to select the most suitable material.The results show that the localized reinforcement with fibres increases thermal storage performance, depending on the type of fibre, creating curvatures in the temperature profile and accelerating the charge/discharge.High-strength, high-conductivity carbon fibres performed well, and the simulation approach can be applied to any fibre arrangement/material.On the contrary, the benefit of the fibres is not straightforward according to the three different scenarios developed for the lca and mcdm analyses, due to the high impact of the fibre production processes.More investigations are needed to balance and optimize the coupling of the fibre material and the solid medium to obtain high thermal performance and low impacts.

Journal: Materials (Basel, Switzerland) (2021)
Publication types: Journal Article
A Novel Educational Control Group Mobile App for Meditation Interventions: Single-Group Feasibility Trial.

Smartphone ownership is becoming ubiquitous among us adults, making the delivery of health interventions via a mobile app (ie, mobile health [m health]) attractive to many researchers and clinicians.Meditation interventions have become popular and have been delivered to study participants via mobile apps to improve a range of health outcomes in both healthy adults and those with chronic diseases.However, these meditation m health interventions have been limited by a lack of high-quality control groups.More specifically, these studies have lacked consistency in their use of active, time-matched, and attention-matched control groups.Objective the purpose of this study is to beta test a novel health education podcast control condition delivered via a smartphone app that would be a strong comparator to be used in future studies of app-based meditation interventions.Methods patients with myeloproliferative neoplasm (mpn) cancer were recruited nationally.Upon enrollment, participants were informed to download the investigator-developed health education podcast app onto their mobile phone and listen to ~60 min/week of cancer-related educational podcasts for 12 weeks.The benchmarks for feasibility included ≥70% of participants completing ≥70% of the prescribed 60 min/week of podcasts, ≥70% of participants reporting that they were satisfied with the intervention, and ≥70% of participants reporting that they enjoyed the health education podcasts.Results a total of 96 patients with mpn were enrolled in the study; however, 19 never began the intervention.Of the 77 patients who participated in the intervention, 39 completed the entire study (ie, sustained participation through the follow-up period).Participation averaged 103.2 (sd 29.5) min/week.For 83.3% (10/12) of the weeks, at least 70% of participants completed at least 70% of their total prescribed use.Almost half of participants reported that they enjoyed the health education podcasts (19/39, 48.7%) and were satisfied with the intervention (17/39, 43.6%).There were no significant changes in cancer-related outcomes from baseline to postintervention.Conclusions a 12-week, health education podcast mobile app was demanded but not accepted in a sample of patients with cancer.Using the mobile app was not associated with significant changes in cancer-related symptoms.Based on findings from this study, a health education podcast mobile app may be a feasible option as a time- and attention-matched control group for efficacy trials with more extensive formative research for the content of the podcasts and its acceptability by the specific population.Trial registration clinical trials.gov nct03907774;

Journal: JMIR formative research (2020)
Publication types: Journal Article
The Evolution of Retzius-Sparing Robot-Assisted Laparoscopic Prostatectomy: An Idea, Development, Evolution, Assessment, and Long-Term Study Perspective.

The retzius-sparing (rs) approach represents an important surgical innovation in how robot-assisted laparoscopic prostatectomy (ralp) is performed.The aim of this study was to examine to what extent its development has followed the idea, development, evolution, assessment, and long-term study (ideal) recommendations.materials and methods:we conducted a comprehensive literature search for studies up to the 18th of march 2021.Abstracted data points included authorship, year of publication, study design, reported endpoints, and length of follow-up.We mapped each study to the five ideal stages of surgical innovation using published criteria.results:of 415 references, 118 were included in our analysis.Five academic centers authored >50% of all study reports, with the groups from seoul (24; 20.3%), milan (15; 12.7%), and ninjang (10; 8.5%) being the main contributors.Approximately 40% of studies (50/118) were reported as full-text publications.Most of the reports mapped to retrospective studies (97/118; 82.2%) with approximately one-third (31/97; 32.0%) reporting the use of prospectively collected data.Cumulatively, 17,974 were reported on rs-ralp.Of those, 13,929 were unique cases.Approximately 23% of cases were reported in multiple publications (4045/17,974).We mapped 2, 12, and 3 studies to the idea, assessment, and long-term study stages, respectively, and no study to the development and evaluation stages.conclusions:few reported studies followed the ideal stages for surgical innovation; none addressed the stages of development and evaluation.Future systematic prospectively planned assessments would be helpful to refine the approach and address issues related to the surgical learning curve.

Journal: Journal of endourology (2022)
Publication types: Journal Article
Relationship between empathic processing and drinking behavior in project MATCH.

Introduction family relationships, social connectedness and a greater network of supportive others each predict better drinking outcomes among individuals with alcohol use disorder (aud).The association between social factors and drinking may be related to the ability of individuals to take the perspectives of others' mental and emotional states, defined as empathic processing (ep).As such, it may be the case that ep is associated with social support (ss) and drinking behavior among individuals with aud, yet few prior studies have attempted to define ep in an aud sample.Methods the current study was a secondary data analysis of project match (n=1726) using structural equation modeling to model ep as a latent factor.The study also sought to test the baseline associations between ep, ss, and drinking behavior, as well as sex differences in the associations between ep, ss, and drinking.It was hypothesized that ep would be positively associated with ss and negatively associated with drinking behavior.Results results suggested adequate model fit of the ep construct.Structural equation models indicated significant associations between ep, ss, and both drinking consequences and percent drinking days, but only for males.Males reported significantly lower ep and ss from friends, but more ss from family, compared to females.Ep was not related to drinking among females.Conclusions the current study validated a model of ep in a treatment-seeking sample of individuals with alcohol use disorder.Future work may consider ep as a treatment-modifiable risk factor for drinking frequency and consequences in males.

Journal: Addictive behaviors (2018)
Publication types: Journal Article
A Scoping Review on the Reported Evidence and Gaps of the Risk of Diabetes in Dyslipidemic Patients under Statin Therapy.

With the increasing global burden of dyslipidemia over the past 30 years, it is estimated that more than 200 million people worldwide are under statin therapy.In india, roughly 25-30% of urban populations and 15-20% of rural populations have abnormal lipid levels.Statin, which is deemed to be the gold standard lipid-lowering agent, is the first treatment of choice for these patients.Although statins at one end are highly effective against dyslipidemiaand cardiovascular diseases, at the other end, they cause adverse effects including an increased risk of diabetes mellitus.The objective of this study was to understand the coexistence of diabetes and dyslipidemia in patients undergoing statin therapy.A scoping review was conducted with published articles selected from pub med and google scholar.The obtained results were filtered based on inclusion/exclusion criteria.Our database search provided a total of 822 articles, of which 48 were selected for this review, with results concluding that statin users are potentially at a greater risk of developing diabetes mellitus compared with patients who are not using statins.Although many studies have been conducted to ascertain the onset of diabetes mellitus amongst statin users, the exact mechanism is not yet precisely established.Future studies are essential for identifying the exact cause of diabetes mellitus in statin users.

Journal: Clinics and practice (2022)
Publication types: Journal Article;Review
Characterization of the aroma release and perception of white bread during oral processing by gas chromatography-ion mobility spectrometry and temporal dominance of sensations analysis.

The purpose of this study was to investigate the aroma release and perception from white bread during oral processing by gas chromatography-ion mobility spectrometry (gc-ims) and dynamic sensory evaluation of temporal dominance of sensations (tds).Tds curves indicated that two maximum aroma perception signals, fermentation-like and flour-like attributes, were perceived at the beginning and swallowing, respectively.The fermentation-like, flour-like, and sour attributes were the 3 dominant aromas during oral processing.A total of 35 volatile compounds were detected in the mouth cavity during chewing white bread, 19 of them were confirmed and quantified by using the respective external standard.Based on plsr analysis, 8 aroma compounds were predicted as potent odorants contributing to the aroma perception from chewing white bread.By application of odor activity values analysis and addition experiments, ethyl butanoate, butyl acetate, hexanal, 3-(methylthio)-propanal, 3-methylbutanal, and 2,3-butanedione were confirmed as the key odorants contributing to the aroma perception during chewing of white bread.

Journal: Food research international (Ottawa, Ont.) (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Metachronous Wilms Tumor, Glioblastoma, and T-cell Leukemia in an Child With Constitutional Mismatch Repair Deficiency syndrome due to Novel Mutation in MSH6 (c.2590G>T).

Constitutional mismatch repair deficiency (cmmrd) is an autosomal recessively inherited childhood cancer predisposition syndrome results from biallelic germline mutations affecting the key dna mismatch repair gene: mlh1, msh2, msh6, or pms2.Cmmrd is associated with a high risk of developing early onset of central nervous system tumors, hematologic, and intestinal tract tumors.Clinical manifestations, genetic screening, and cancer prevention strategies are limited.In this report we present a patient with metachronous wilms tumor, glioblastoma, and acute t-cell lymphoblastic leukemia.He had cutaneous features of neurofibromatosis type 1 (nf1).Molecular testing revealed a novel homozygous mutation in msh6 (c.2590g>t; p.g864*) that has not been reported previously.Cmmrd should be considered in patients with cutaneous features similar to nf1 if tumor is found other than expected tumors in nf, early onset cancer, and strong family history of cancer.

Journal: Journal of pediatric hematology/oncology (2021)
Publication types: Case Reports;Journal Article
A culturally responsive evaluation framework and its application in environmental education.

Despite the many challenges inherent in conducting high-quality evaluations in the field of environmental education (ee), there is a growing recognition of the importance of evaluation, not only to gauge program success, but also to use evaluation results to improve programming, support organizational learning, and ensure programs are meeting the needs of diverse audiences.The challenges to conducting high-quality evaluations are exacerbated by historical issues of inequity and systemic racism that are pervasive in the united states and globally.We reviewed the literature on culturally responsive approaches to evaluation to propose a culturally responsive evaluation framework and consider its application in ee.This framework helps ee organizations and evaluators consider how issues of race, power, privilege, and inequity influence the evaluation process and the validity of evaluation findings.Implementing this framework may be resource-intensive, but it has the potential to improve evaluation processes and produce actionable results to further address issues of diversity, equity, and inclusion in the field of ee.We call for organizations that support ee efforts to recognize the importance of this approach, and provide adequate resources to encourage its implementation.

Journal: Evaluation and program planning (2022)
Publication types: Journal Article;Review
Maneuvering the Management of a Rare Case of Primary Undifferentiated Cardiac Sarcoma.

Primary cardiac tumors are rare and mostly benign.Cardiac sarcomas are the most common malignant neoplasms of the heart and harbor a dismal prognosis of 6 to 12 months.The diagnosis of cardiac sarcomas may be challenging.Treatment entails surgical resection despite the high rate of recurrence, as well as adjuvant chemotherapy.Case report in this report, we discuss a case of a 58-year-old male with undifferentiated pleomorphic primary cardiac sarcomas who received multiple lines of treatment that included surgery, chemotherapy, and targeted therapy and was alive more than 4 years after his diagnosis.Herein, we discuss the different treatment regimens utilized and we present detailed imaging of his case findings at different treatment stages.Conclusions treatment of undifferentiated pleomorphic cardiac sarcoma requires a multidisciplinary approach.Surgery and adjuvant treatment are commonly utilized, while neoadjuvant treatment is under investigation.

Journal: The American journal of case reports (2020)
Publication types: Case Reports;Journal Article
Long-term fertilization lowers the alkaline phosphatase activity by impacting the phoD-harboring bacterial community in rice-winter wheat rotation system.

Pho d-harboring bacteria and the secreted alkaline phosphatases (alp) are crucial in the regulation of soil phosphorus (p) cycling.However, the influential factors of these crucial indicators and their internal interactions remain controversial.Here, a long-term field experiment containing different fertilization regimes was conducted (chemical, organic, and no fertilizer applied).The results indicated that the richness and diversity of pho d-harboring bacterial community were significantly decreased after long-term fertilization.The applied fertilizer promoted the growth of competitive species, while pho d-harboring bacteria lost the advantage to outcompete other microorganisms after long-term fertilization.The decreased alp activity was caused by the declined pho d gene abundance, which is attributed to the comprehensive effects of soil organic c (soc), total nitrogen (tn), and various forms of p.The random forest models identified soc, tn, and available p (ap) to be the dominant environmental factors in shaping the pho d-harboring bacterial community.In addition, some other forms of p such as organic p (po), inorganic p (pi) or total p (tp) also exerted significant effects.Different fertilization regimes changed the keystone genera that contributed significantly to soil alp activities, while pseudolabrys and pseudomonas were predicted to be the most important genera regardless of different fertilization regimes.This study extends the understanding of the main process and mechanisms of p mobilization in response to different fertilization regimes.

Journal: The Science of the total environment (2022)
Publication types: Journal Article