syedzayyan/paper_mill_benchmark huggingface dataset:
Spectroscopic aspects for the Yb3+coordination compound with a large energy gap between the ligand and Yb3+excited states.

We present the experimental and theoretical results that made it possible to propose the energy transfer mechanism for a yb complex with a large energy gap between the ligand and yb excited states using a theoretical model and experimental data.Absorption and emission spectroscopy in the 300-4 k range is used for the study of the yb3+compound with n-phosphorylated sulfonamide (na[yb l4]), which, despite the large energy gap, is characterized by high emission sensitization efficiency (ηsens= 40%) and relatively long yb3+emission lifetime (27 μs).The crystal structure of na[yb l4], radiative lifetime (930 μs), refractive index (1.46), intrinsic (3.0%), and overall (1.3%) emission quantum yield were determined.To obtain the electronic properties of the na[yb l4], a time-dependent density functional theory (td-dft) was performed.The intramolecular energy transfer (iet) rates from the excited states s1and t1to the yb3+ion as well as between the ligand and the ligand-to-metal charge transfer (lmct) states were calculated.Once the intersystem crossing s1→ t1is not so effective due to a large energy gap between s1and t1(≈10000 cm-1), it has been shown that the lmct state acts as an additional channel to feed the t1state.Then, the t1can transfer energy to the yb3+ 2f5/2energy level (wt), where wtis dominated by the exchange mechanism.Based on iet and a rate equation model, the overall emission quantum yield qllnwas simulated with and without the lmct, this also confirmed that the pathway s1→ lmct → t1→ yb3+is more likely than the s1→ t1→ yb3+one.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2022)
Publication types: Journal Article
Predictors of behavioral cancer risk factors and preventive behaviors among Nebraskans.

The overall incidence rate of cancer in nebraska is higher than the national average with cancer being the second leading cause of death in the state.Interventions are required to reduce the cancer burden; however, further research is first needed to identify behavioral cancer risk factors and preventive behaviors among nebraskans that can be targeted.Methods a statewide cross-sectional survey of nebraskans aged 19 and older was conducted in 2019 using an address-based sampling method (n = 1640).Multivariable logistic regression was used to examine factors associated with being up-to-date on cancer screening and with behavioral cancer risk factors and preventive behaviors.Results 93.42% of nebraskans did not meet the daily recommended consumption of fruits and vegetables, and 71.51% did not meet weekly physical activity guidelines.The proportion of adults up to date on cancer screening was 64.57% for breast, 68.83% for cervical, 69.01% for colorectal, and 24.07% for skin cancers.Individuals 65-74 (or: 3.40, 95% ci: 1.52-7.62) and 75 or older (or: 3.30, 95% ci: 1.35-8.07) were more likely to be current with their colorectal cancer screening compared to ages 50-64.Hispanics were less likely to be current with mammograms (or: 0.06, 95% ci: 0.01-0.71) and ever screened for cervical cancer (or:0.13, 95% ci: 0.02-0.94) compared to non-hispanic whites.Conclusions disparities in cancer screening and risk and preventive behaviors exist in nebraska.Impact the study highlights a need for continuing efforts to improve preventive cancer behaviors for the entire population as well as some high-risk populations in nebraska.

Journal: Cancer epidemiology (2022)
Publication types: Journal Article
Cocaine Self-Administration Influences Central Nervous System Immune Responses in Male HIV-1 Transgenic Rats.

Cocaine use increases the neurotoxic severity of human immunodeficiency virus-1 (hiv-1) infection and the development of hiv-associated neurocognitive disorders (hand).Among the studied cellular mechanisms promoting neurotoxicity in hiv-1 and cocaine use, central nervous system (cns) immunity, such as neuroimmune signaling and reduced antiviral activity, are risk determinants; however, concrete evidence remains elusive.In the present study, we tested the hypothesis that cocaine self-administration by transgenic hiv-1 (hiv-1tg) rats promotes cns inflammation.To test this hypothesis, we measured cytokine, chemokine, and growth factor protein levels in the frontal cortex (f ctx) and caudal striatum (c str).Our results demonstrated that cocaine self-administration significantly increased f ctx inflammation in hiv-1tgrats, but not in the c str.Accordingly, we postulate that cocaine synergizes with hiv-1 proteins to increase neuroinflammation in a region-selective manner, including the f ctx.Given the f ctx role in cognition, this interaction may contribute to the hyperimmunity and reduced antiviral activity associated with cocaine-mediated enhancement of hand.

Journal: Cells (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Evidence for hexasomic inheritance inChrysanthemum morifoliumRamat. based on analysis of EST-SSR markers.

Chrysanthemums (chrysanthemum morifolium ramat.) are ornamental flowers, which are famous worldwide.The mode of inheritance has great implications for the genetic analysis of polyploid species.However, genetic analysis of chrysanthemum has been hampered because of its controversial inheritance mode (disomic or hexasomic).To classify the inheritance mode of chrysanthemums, an analysis of three approaches was carried out in an f1progeny of 192 offspring using 223 expressed sequence tag-simple sequence repeat (est-ssr) markers.The analysis included segregation analysis, the ratio of simplex marker alleles linked in coupling to repulsion, as well as the transmission and segregation patterns of est-ssr marker alleles.After segregation analysis, 204 marker alleles fit hexasomic inheritance and 150 marker alleles fit disomic inheritance, showing that marker alleles were inherited predominantly in a hexasomic manner.Furthermore, the results of the analysis of allele configuration and segregation behavior of five est-ssr markers also suggested random pairing of chromosomes.Additionally, the ratio of simplex marker alleles linked in coupling to repulsion was 1:0, further supporting hexasomic inheritance.Therefore, it could be inferred that chrysanthemum is a complete or near-complete hexasome.

Journal: Genome (2022)
Publication types: Journal Article
The metabolomics of psoriatic disease.

Metabolomics is an emerging new "omics" field involving the systematic analysis of the metabolites in a biologic system.These metabolites provide a molecular snapshot of cellular activity and are thus important for understanding the functional changes in metabolic pathways that drive disease.Recently, metabolomics has been used to study the local and systemic metabolic changes in psoriasis and its cardiometabolic comorbidities.Such studies have revealed novel insights into disease pathogenesis and suggest new biochemical signatures that may be used as a marker of psoriatic disease.This review will discuss common strategies in metabolomics analysis, current findings in the metabolomics of psoriasis, and emerging trends in psoriatic metabolomics.

Journal: Psoriasis (Auckland, N.Z.) (2017)
Publication types: Journal Article
PTH2R is related to cell proliferation and migration in ovarian cancer: a multi-omics analysis of bioinformatics and experiments.

Ovarian cancer is a common gynecological disease and seriously endangers women's health.Currently, there is still a lack of effective molecular markers for the diagnosis and treatment of ovarian cancer.The present study aimed to investigate the molecular markers associated with ovarian cancer.Methods the molecular and gene related to ovarian cancer were extracted from geo database and tcga database by bioinformatics, and the related genes and functions were further analyzed.The results were verified by q pcr, wb, cck-8 and transwell experiments.Results data analysis showed that pth2r gene was highly expressed in tumors, and 51 hub genes were obtained.Finally, experimental verification showed that pth2r gene was highly expressed in ovarian cancer, and pth2r gene was involved in the proliferation, invasion and metastasis of ovarian cancer cells.Conclusions after experimental verification, we found that knocking down the expression of pth2r can inhibit the proliferation, invasion and migration of tumor cells.pth2r is expected to become a new molecular marker for ovarian cancer.

Journal: Cancer cell international (2022)
Publication types: Journal Article
Wood-Derived, Conductivity and Hierarchical Pore Integrated Thick Electrode Enabling High Areal/Volumetric Energy Density for Hybrid Capacitors.

For the proliferation of the supercapacitor technology, it is essential to attain superior areal and volumetric performance.Nevertheless, maintaining stable areal/volumetric capacitance and rate capability, especially for thick electrodes, remains a fundamental challenge.Here, for the first time, a rationally designed porous monolithic electrode is reported with high thickness of 800 μm (46.74 mg cm-2, with high areal mass loading of ni co2s46.9 mg cm-2) in which redox-active ag nanoparticles and ni co2s4nanosheets are sequentially decorated on highly conductive wood-derived carbon (wc) substrates.The hierarchically assembled wc@ag@ni co2s4electrode exhibits outstanding areal capacitance of 6.09 f cm-2and long-term stability of 84.5% up to 10 000 cycles, as well as exceptional rate capability at 50 m a cm-2.The asymmetric cell with an anode of wc@ag and a cathode of wc@ag@ni co2s4delivers areal/volumetric energy density of 0.59 m wh cm-2/3.93 m wh cm-3, which is much-improved performance compared to those of most reported thick electrodes at the same scale.Theoretical calculations verify that the enhanced performance could be attributed to the decreased adsorption energy of oh-and the down-shifted d-band of ag atoms, which can accelerate the electron transport and ion transfer.

Journal: Small (Weinheim an der Bergstrasse, Germany) (2021)
Publication types: Journal Article
Nanodiamonds as Nucleating Agents for Protein Crystallization.

Nanodiamond (nd) is a carbon-based nanomaterial with potential for a wide range of biological applications.One of such applications is to facilitate the nucleation of protein crystals in aqueous solution.Here, we show that nds (nominal diameters of 30 and 100 nm) after surface oxidation in air and subsequent treatment in strong acids are useful as heterogeneous nucleating agents for protein crystallization.Tested with lysozyme, ribonuclease a, proteinase k, and catalase, the nanomaterials in either aggregate or film form are found to be able to increase the crystallization efficiency of all proteins.Particularly, for 30 nm nds, the films with an area of ∼2 mm2can effectively induce the crystallization of lysozyme at a concentration as low as 5 mg/m l.The efficiency can be further improved by adding preformed protein clusters (∼300 nm in diameter) as inherent nucleation precursors, as demonstrated for ribonuclease a.This combined approach is easy to implement, highly compatible with existing technologies, and can be applied to other protein samples as well.

Journal: Langmuir : the ACS journal of surfaces and colloids (2017)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Claw sign of brachial plexopathy on18F-FDG PET/CT in neurolymphomatosis following successful treatment of lymphoma.

Neurolymphomatosis is a rare neurological manifestation associated with non-hodgkin's lymphoma.Here we present a case of brachial plexus neurolymphomatosis in a patient with relapsed non-hodgkin's lymphoma exquisitely demonstrated on18f-fdg pet/ct.It highlights the characteristic imaging features and importance of multimodality imaging in diagnosing neurolymphomatosis.

Journal: European journal of hybrid imaging (2022)
Publication types: Journal Article
The Second Human Pegivirus, a Non-Pathogenic RNA Virus with Low Prevalence and Minimal Genetic Diversity.

The second human pegivirus(hpg v-2) is a virus discovered in the plasma of ahepatitis c virus(hcv)-infected patient in 2015 belonging to thepegivirusesof the family flaviviridae.Hpg v-2 has been proved to be epidemiologically associated with and structurally similar to hcv but unrelated to hcv disease and non-pathogenic, but its natural history and tissue tropism remain unclear.Hpg v-2 is a unique rna virus sharing the features of hcv and the first human pegivirus (hpg v-1 or gbv-c).Moreover, distinct from most rna viruses such as hcv, hpg v-1 and human immunodeficiency virus (hiv), hpg v-2 exhibits much lower genomic diversity, with a high global sequence identity ranging from 93.5 to 97.5% and significantly lower intra-host variation than hcv.The mechanisms underlying the conservation of the hpg v-2 genome are not clear but may include efficient innate immune responses, low immune selection pressure and, possibly, the unique features of the viral rna-dependent rna polymerase (rd rp).In this review, we summarize the prevalence, pathogenicity and genetic diversity of hpg v-2 and discuss the possible reasons for the uniformity of its genome sequence, which should elucidate the implications of rna virus fidelity for attenuated viral vaccines.

Journal: Viruses (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't
Systematic review and meta-analysis of ketamine-associated uropathy.

Introduction this systematic review and meta-analysis focused on the literature regarding ketamine-associated uropathy to summarise its clinical manifestations, the results of urological assessments, and current management.Methods a literature search was conducted using keywords and me sh terms related to ketamine abuse, urinary tracts, and urological examinations.Databases including embase, medline, and the cochrane central register of controlled trials were searched up to 26 june 2020.Results in total, 1365 articles were retrieved; 45 articles (4921 patients) were included in the analysis of patient demographics, clinical manifestations, examination results, and treatments.Frequency was the most common manifestation (pooled prevalence 77.1%, 95% confidence interval [ci]=56.9%-92.2%), followed by urgency (69.9%, 95% ci=48.8%-87.3%) and suprapubic pain (60.4%, 95% ci=35.3%-82.9%).Upper urinary tract involvement was less common; the pooled prevalence of hydronephrosis was 30.2% (95% ci=22.0%-39.2%).Further workup revealed a pooled functional bladder capacity of 95.23 m l (95% ci=63.57-126.88 m l), pooled voided volume of 113.31 m l (95% ci=59.44- 167.19 m l), and pooled maximum urine flow rate of 8.69 m l/s (95% ci=5.54-11.83 m l/s).Cystoscopic examinations and bladder biopsy revealed frequent urothelial denudation, inflammatory changes, and inflammatory cell infiltration.Treatments included oral medications for symptomatic relief, intravesical therapy, and surgery (eg, hydrodistension and bladder reconstruction), but ketamine abstinence was necessary for improvement.Conclusion ketamine-associated uropathy frequently involves frequency, urgency, and suprapubic pain; upper urinary tract involvement is less common.Affected patients showed reductions in bladder capacity and urine flow rate.Endoscopic and histological analyses often revealed cystitis.Despite variations in treatment, ketamine abstinence is important for all patients with ketamine-associated uropathy.

Journal: Hong Kong medical journal = Xianggang yi xue za zhi (2022)
Publication types: Meta-Analysis;Systematic Review;Journal Article
A facile polymer mediated dye incorporation method for fluorescence encoded microbeads with large encoding capacities.

Here we report a facile dye incorporation method for fluorescence encoded microbeads, which is achieved by tuning the mixed polymer type (blank and dye-labeled polymers) and their doping ratio through electrostatic loading into mesoporous beads.This method is universal to various carriers and could render large encoding capacities.

Journal: Chemical communications (Cambridge, England) (2021)
Publication types: Journal Article
Assertive Community Treatment For People With Alcohol Dependence: A Pilot Randomized Controlled Trial.

S a pilot randomized controlled trial (rct) to assess the feasibility and potential efficacy of assertive community treatment (act) in adults with alcohol dependence.Methods single blind, individually randomized, pilot rct of 12 months of act plus treatment as usual (tau) versus tau alone in adults (age 18+ years) with alcohol dependence and a history of previous unsuccessful alcohol treatment attending specialist community alcohol treatment services.Act aimed to actively engage participants for 12 months with assertive, regular, minimum weekly contact.Act was combined with tau.Tau comprised access to the full range of services provided by the community teams.Primary outcome is mean drinks per drinking day and percent days abstinent at 12 months follow up.Analysis of covariance was conducted using 80% confidence intervals, appropriate in the context of a pilot trial.Results a total of 94 participants were randomized, 45 in act and 49 in tau.Follow-up was achieved with 98 and 88%, respectively at 12 months.Those in act had better treatment engagement, and were more often seen in their homes or local community than tau participants.At 12 months the act group had more problems related to drinking and lower quality of life than tau but no differences in drinking measures.The act group had a higher percentage of days abstinent but lower quality of life at 6 months.The act group had less unplanned healthcare use than tau.Conclusions an trial of act was feasible to implement in an alcohol dependent treatment population.Trial registration isrctn22775534.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire) (2017)
Publication types: Journal Article;Randomized Controlled Trial
Brassinosteroids and metalloids: Regulation of plant biology.

Metalloid contamination in the environment is one of the serious concerns posing threat to our ecosystems.Excess of metalloid concentrations (including antimony, arsenic, boron, selenium etc.) in soil results in their over accumulation in plant tissues, which ultimately causes phytotoxicity and their bio-magnification.So, it is very important to find some ecofriendly approaches to counter negative impacts of above mentioned metalloids on plant system.Brassinosteroids (brs) belong to family of plant steroidal hormones, and are considered as one of the ecofriendly way to counter metalloid phytotoxicity.This phytohormone regulates the plant biology in presence of metalloids by modulating various key biological processes like cell signaling, primary and secondary metabolism, bio-molecule crosstalk and redox homeostasis.The present review explains the in-depth mechanisms of br regulated plant responses in presence of metalloids, and provides some biotechnological aspects towards ecofriendly management of metalloid contamination.

Journal: Journal of hazardous materials (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Functional and molecular characterization of endothelium-dependent and endothelium-independent relaxant pathways in uterine artery of non-pregnant buffaloes.

Present study was undertaken to unravel the endothelium-dependent and endothelium-independent relaxant pathways in uterine artery of non-pregnant buffaloes.Isometric tension of arterial rings was recorded using data acquisition system based polyphysiograph.Acetylcholine (ach) produced endothelium-dependent vasorelaxation by releasing nitric oxide (no), and inhibition of nitric oxide synthase (nos) by l-name (300 μm) significantly (p < 0.05) reduced the no release and thereby the vasorelaxant effect of ach.However, l-nmma, another nos inhibitor, and ptio, a no scavenger, did not have any additional inhibitory effect on no and ach-induced vasorelaxation.Cyclooxygenase (cox) inhibitor (indomethacin) alone did not have any inhibitory action on vasorelaxant response to ach; however, simultaneous inhibition of cox and nos enzymes significantly (p < 0.05) attenuated the relaxant response indicating the concurrent release of these two mediators in regulating ach-induced relaxation.Besides nos and cox-derived metabolites (edrf), small (skca) and intermediate (ikca) conductance k+channels being the members of edhf play predominant role in mediating ach-induced vasorelaxation.Using different molecular tools, existence of e nos, cox-1, and,ikcain the endothelium, bkcain vascular smooth muscle, and skcain both endothelium and vascular smooth muscle was demonstrated in buffalo uterine artery.Gene sequencing of cox-1 and skcagenes in uterine artery of buffaloes showed more than 97% structural similarity with ovine (ovis aries), caprine (capra hircus), and indian cow (bos indicus).Endothelium-independent nitrovasodilator, sodium nitroprusside (snp), produced vasorelaxation which was sensitive to blockade by soluble guanylate cyclase (s gc) inhibitor (odq), thus suggesting the important role of c gmp/pkg pathways in uterine vasorelaxation in buffaloes.Taken together, it is concluded that both endothelium-dependent (edhf and edrf) and endothelium-independent (s gc-c gmp) relaxant pathways are present in uterine arteries of non-pregnant buffaloes, and they differently contribute to vasorelaxation during non-pregnant state.

Journal: Naunyn-Schmiedeberg's archives of pharmacology (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Open-source magnetic resonance imaging acquisition: Data and documentation for two validated pulse sequences.

Raw data, simulated and acquired phantom images, and quantitative longitudinal and transverse relaxation times (t1/t2) maps from two open-source magnetic resonance imaging (mri) pulse sequences are presented in this dataset along with corresponding ".seq" files, sequence implementation scripts, and reconstruction/analysis scripts [1].Real mri data were collected from a 3t siemens prisma fit and a 1.5t siemens aera via the pulseq open-source mr sequence platform, and corresponding in silico data were generated using the simulation module of virtual scanner [2].This dataset and its associated code can be used to validate the pipeline for using the same pulse sequences at other research sites using pulseq, to provide guidelines for documenting and sharing open-source pulse sequences in general, and to demonstrate practical, customizable acquisition scripts using the py pulseq library.

Journal: Data in brief (2022)
Publication types: Journal Article
A JAM-A-tetraspanin-αvβ5 integrin complex regulates contact inhibition of locomotion.

Contact inhibition of locomotion (cil) is a process that regulates cell motility upon collision with other cells.Improper regulation of cil has been implicated in cancer cell dissemination.Here, we identify the cell adhesion molecule jam-a as a central regulator of cil in tumor cells.Jam-a is part of a multimolecular signaling complex in which tetraspanins cd9 and cd81 link jam-a to αvβ5 integrin.Jam-a binds csk and inhibits the activity of αvβ5 integrin-associated src.Loss of jam-a results in increased activities of downstream effectors of src, including erk1/2, abi1, and paxillin, as well as increased activity of rac1 at cell-cell contact sites.As a consequence, jam-a-depleted cells show increased motility, have a higher cell-matrix turnover, and fail to halt migration when colliding with other cells.We also find that proper regulation of cil depends on αvβ5 integrin engagement.Our findings identify a molecular mechanism that regulates cil in tumor cells and have implications on tumor cell dissemination.

Journal: The Journal of cell biology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't