syedzayyan/paper_mill_benchmark huggingface dataset:
Effect of topical application of autologous platelet gel on sternal wound infection after cardiac surgery: A meta-analysis

Following heart operation, a severe life‐threatening complication has been identified by investigators who have recently discovered that local application of platelet‐rich plasma (prp) can lower the rate of wound infection in heart surgery.Nevertheless, due to the low quality of these trials, we have tried to perform high‐quality meta‐analyses to prove the efficacy of prp in heart surgery for post‐operative wound infections.In this study, five randomised controlled trials (rcts) were chosen from three databases, and there were 1005 studies to analyse the data.Among 181 cases, prp was applied to the surgical site, and 205 in the control group.Both the ci and the or or the average difference (md) were computed with either a fixed or random‐effect model.A meta‐analysis of the data was carried out with rev man 5.3.The results showed that there were no statistically significant differences in the incidence of post‐operative surgical site infection (ssi) in control group compared to those treated with prp gel (or, 0.97; 95% ci, 0.38, 2.47; p = 0.95); in the heart operation, the local application of prp gel decreased the rate of drainage after operation (md, −217.82; 95% ci, −335.38, −100.26; p = 0.0003); the operation time of the prp gel was not significantly different from that of the control group (md, 12.65; 95% ci, −2.95, 28.24; p = 0.11).Contrary to earlier research, the application of autoplatelet gel in heart surgery did not seem to decrease operative site infections after the operation, but it did decrease the amount of postoperative drainage.Nevertheless, because of the limited number of rcts in this meta‐analysis, caution should be exercised in their treatment.More high‐quality randomised, large‐sample trials are required to further confirm the findings.

Journal: International Wound Journal (2024)
Publication types: Meta-Analysis;
The effect of traditional Chinese medicine soaking method on the healing of diabetic foot ulcers: A meta-analysis

Foot infections, sores or deep tissue damage from diabetes can be a serious psychological and physical injury.This paper aims at making meta‐analyses on the therapeutic effects of traditional chinese medicine (tcm) on diabetic foot ulcers.The chinese national knowledge infrastructure, vip database, wanfang database and so on, has conducted a randomized controlled trial to evaluate the clinical effect of tcm soaking method for diabetes patients with diabetes.Literature has been determined to be included by computer search and by hand rough checks.The search period was from the creation of the database to october 2023.Review manager 5.3 was used to analyse the meta data and evaluate it systematically.Altogether, 479 research was conducted in china's data base and 20 of them were eventually collected for the final statistical analysis.In all, 1361 patients were enrolled in the trials.The results indicated that tcm immersion in diabetic foot resulted in significantly improved obvious wound healing (or, 3.2; 95% ci, 2.5, 4.09, p &lt; 0.0001); results showed that tcm immersion therapy significantly increased the efficiency of effective wound healing (or, 4.55; 95% ci, 3.25, 6.37, p &lt; 0.001).Statistical significance was found.Using egger's approach to detect publishing bias suggests that there is no risk of publishing bias in terms of marked wound healing and effective healing.Traditional chinese drug immersion can increase obviously the recovery ratio and the effective recovery ratio of diabetic foot.

Journal: International Wound Journal (2024)
Publication types: Meta-Analysis;
Tobacco Leaves Disease Identification and Spot Segmentation Based on the Improved ORB Algorithm

In order to improve the problems of poor accuracy and low efficiency in tobacco leaves disease recognition and diagnosis and avoid the misjudgment in tobacco disease recognition, a disease recognition and spot segmentation method based on the improved orb algorithm was proposed.The improved fast14-24 algorithm was used to preliminarily extract corners.It overcame the deficiency of the sensitivity of the traditional orb corner detection algorithm to image edges.During the experiment, 28 parameters were obtained through the extraction of color features, morphological features, texture, and other features of tobacco disease spots.Through the experimental comparisons, it was found that the fitness of the improved orb algorithm was 96.68 and the cross-checking rate was 93.21%.The validation and recognition rate for samples was 96%.The identification rate of tobacco brown spot disease and frog eye disease was 92%, and the identification rate of 6 categories in different periods was over 96%.The experimental results verified the effects of the disease identification fully.

Journal: Scientific Programming (2022)
Publication types: Research Article;
The Value of Rivaroxaban Combined with Ticagrelor in Antithrombotic Therapy after PCI in Patients with Nonvalvular Atrial Fibrillation with Acute Coronary Syndrome

Based on a retrospective cohort study, to investigate the value of rivaroxaban combined with ticagrelor in antithrombotic therapy after pci in patients with nonvalvular atrial fibrillation with acute coronary syndrome.Methods.A total of 60 patients from january 2019 to may 2021 accepted therapy with antithrombotic therapy after pci.The patients treated with ticagrelor were set as the control group, and those given rivaroxaban combined with ticagrelor were set as the research group.The curative effect, myocardial level, timi blood flow grade, platelet aggregation rate, and the incidence of cardiovascular events were taken from the comparisons.Results.The research group’s therapeutic impact was superior to the control group’s therapeutic impact, and the value was higher.After treatment, the myocardial levels of the two groups decreased, and the levels of troponin i, creatine kinase isoenzyme, and hypersensitive c-reactive protein in the research group were greatly less than those in the control group, and the difference was statistically significant ( p &lt; 0.05 ).After operation, the timi blood flow classification in the experimental group was better than that in the control group, and the difference was statistically significant ( p &lt; 0.05 ).The experimental group’s platelet aggregation incidence was considerably lower than the control group’s platelet aggregation incidence at 0.5 and 2 hours following surgery, and the difference was statistically significant ( p &lt; 0.05 ).The incidence of acute myocardial infarction, cardiogenic death, and intractable angina pectoris in the research group was significantly lower than that in the control group.Conclusion.Rivaroxaban combined with ticagrelor in the treatment of nonvalvular atrial fibrillation with acute coronary syndrome after percutaneous coronary intervention; the timi blood flow grade is better than ticagrelor, which is of great significance to reduce mortality and has high safety in clinical application.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
The Oral Tumor Cell Exosome miR-10b Stimulates Cell Invasion and Relocation via AKT Signaling

An exosome derived from a cancer cell has been identified to regulate intercellular communication.However, the roles of oral cancer‐derived ectodomains in tumor metastasis need to be investigated further.We investigated their roles in oral cancer cells in this paper.The enforcing effect on oral cancer cells was attributed primarily to mi r‐10b, a gene with a high level in exosomes that is transferred to recipient cells via oral cancer‐derived exosomes.Exosomes were obtained by exosome isolation reagents.Also, exosome identification and analysis were performed by electron microscopy.The expression of mi rnas was analyzed by q rt‐pcr.Protein expression was analyzed by western blot.Also, invasion and migration experiments were performed to assay and evaluate the function of exosomal mi r‐10b.Exosome‐mediated transfer of mi r‐10b promoted oral cancer cell behaviors, according to the findings.Finally, it was discovered that akt signaling participates in regulating exosome‐mediated invasion and migration of oral cancer cells and its activation reduced the inhibitory effect of mi r‐10b knockdown on oral cancer cells.Exosomal mi r‐10b derived from oral cancer cells enhances cell invasion and migration by activating akt signaling.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Motion Control and Tracking Control of UAV Based on Adaptive Sensor

In order to meet the requirements of uav motion control and tracking control, an adaptive sensor‐based technology is proposed.The main content of the technology is based on the mathematical model of the adaptive sensor, through the quaternion attitude update model, using nonlinear attitude svdck filtering and dynamic adaptive adjustment factors and other technologies, and finally through simulation experiments and analysis to build the research means of uav motion control and tracking control system.The experimental results show that the roll angle, pitch angle, and yaw angle of svdckf are 1.703, 1.972, and 1.928, respectively.By adjusting the dynamic adaptive factor, the attitude‐filtering algorithm reduces the error of the attitude solution and improves the robustness of the attitude solution under high dynamic conditions.Conclusion .The technology research based on adaptive sensor can meet the requirements of uav motion control and tracking control.

Journal: Journal of Sensors (2023)
Publication types: Research Article;
Molecular Docking and Green Synthesis of Bioinorganic TiO2 Nanoparticles against E.coli and S.aureus

This study used a simple solution evaporation approach to make a bioinorganic titanium dioxide (bi‐ti o 2 ) photocatalyst for dye contaminant degradation.A variety of techniques, including x ‐ray diffraction (xrd), fourier‐transform infrared (ft‐ir) spectroscopy, scanning electron microscopy (sem) coupled with energy dispersive x ‐ray analysis (edax), and differential reflectance spectroscopy, had been employed to classify the structural and optical properties of the prepared bioinorganic photocatalyst (uv‐drs).Using simulated solar irradiation, the photocatalytic activity of the produced bi‐ti o 2 nanoparticles was examined by detecting the degradation of a solution of methylene blue (mb) as a model dye molecule.The developed bi‐ti o 2 photocatalyst demonstrates superior photocatalytic action than commercially available powder ti o 2 , according to photo‐degradation experiments.E.Coli and s.Aureus bacterial strains were employed to assess the antibacterial activity of bi‐ti o 2 nanoparticles.The most active molecules that gain antibacterial activity were examined in isolated or extracted components from the tulsi plant.The chosen compounds were docked with thymidylate kinase (tmpk), a potential therapeutic goal for the preparation of novel antibacterial drugs with the pdb id of 4qgg.Five compounds, namely rosmarinic acid, vicenin‐2, orientin, vitexin, and isoorientin, out of the 27 chosen compounds, showed a higher docking score and may aid in boosting antibacterial activity.The synthesized bi‐ti o 2 nanoparticles produced antibacterial activity that was effective against gram‐positive bacteria.The nanomaterials that have been synthesized have a lot of potential in wastewater treatment and biomedical management technologies.

Journal: Bioinorganic Chemistry and Applications (2022)
Publication types: Research Article;
Modified Activated Carbon: A Supporting Material for Improving Clostridium beijerinckii TISTR1461 Immobilized Fermentation

This study aimed to investigate the effect of activated carbon (ac) as an immobilization material in acetone-butanol-ethanol fermentation.The ac surface was modified with different physical (orbital shaking and refluxing) and chemical (nitric acid, sodium hydroxide and, (3-aminopropyl)triethoxysilane (aptes)) treatments to enhance the biobutanol production by clostridium beijerinckii tistr1461.The effect of surface modification on ac was evaluated using fourier-transform infrared spectroscopy, field emission scanning electron microscopy, surface area analyses, and x-ray photoelectron spectroscopy, while the fermented broth was examined by high-performance liquid chromatography.The chemical functionalization significantly modified the physicochemical properties of the different treated acs and further enhanced the butanol production.The ac treated with aptes under refluxing provided the best fermentation results at 10.93 g/l of butanol, 0.23 g/g of yield, and 0.15 g/l/h of productivity, which were 1.8-, 1.5-, and 3.0-fold higher, respectively, than that in the free-cell fermentation.The obtained dried cell biomass also revealed that the treatment improved the ac surface for cell immobilization.This study demonstrated and emphasized the importance of surface properties to cell immobilization.

Journal: Bioinorganic Chemistry and Applications (2023)
Publication types: Research Article;
miR-141-3p Targeted SIRT1 to Inhibit Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

To explore the expression of mi r-141-3p during the osteogenic differentiation of human bone marrow mesenchymal stem cells (bmscs) and its regulatory effect.Methods.Differentiation of bmscs was induced by dexamethasone.The m rna expression of mi r-141-3p, alp, runx2, and ocn was measured using rt-q pcr.The protein expression was detected via western blot.The target of mi r-141-3p was predicted through the target scan website and confirmed using luciferase reporter assay.Results.Mi r-141-3p expression declined during osteogenic differentiation.The relative alp activities and the m rna expression of alp, runx2, and ocn were markedly reduced in the mi r-141-3p mimic group while increased in the inhibitor group.Cell viability was suppressed in the mi r-141-3p mimic group and promoted in the inhibitor group.Sirt1 was predicted to be a downstream gene of mi r-141-3p, and this prediction was confirmed via the luciferase reporter assay.The results of the western blot assay demonstrated that sirt1 expression was decreased in the mi r-141-3p mimic group.Sirt1 reversed the inhibitory influence of mi r-141-3p on the osteogenic differentiation ability of bmscs.Conclusion.Mi r-141-3p targeted sirt1 to inhibit osteogenic differentiation of bmscs via the wnt/β-catenin signaling pathway.

Journal: Stem Cells International (2023)
Publication types: Research Article;
MiR-125b-5p/STAT3 Axis Regulates Drug Resistance in Osteosarcoma Cells by Acting on ABC Transporters

The poor prognosis of the highly malignant tumor osteosarcoma stems from its drug resistance and therefore exploring its resistance mechanisms will help us identify more effective treatment options.However, the effects of mi r-125b-5p on drug resistance in osteosarcoma cells are still unclear.Methods.To study the effects of mi r-125b-5p on drug resistance in osteosarcoma cells.Osteosarcoma-resistant mi r-125b-5p was obtained from the databases gene cards and g:profiler.Cck8, western blot, and transwell were applied for the detection of the mi r-125b-5p effects on proliferation, migration, invasion, apoptosis, and drug resistance in osteosarcoma.Bioinformatics is aimed at demonstrating the targeting factor mi r-125b-5p, performing protein interaction enrichment analysis by metascape, and finally validating by binding sites.Results.Upregulation of mi r-125b-5p restrains proliferation, migration, and invasion of osteosarcoma and promotes apoptosis.In addition, mi r-125b-5p can restore drug sensitivity in drug-resistant osteosarcoma.Mi r-125-5p restrains the signal transducer and inhibits the transcription 3 (stat3) expression activator via targeting its 3 ′ -utr.Stat3 affects drug-resistant osteosarcoma to regulate the abc transporter.Conclusion.Mi r-125b-5p/stat3 axis mediates the drug resistance of osteosarcoma by acting on abc transporter.

Journal: Stem Cells International (2023)
Publication types: Research Article;
Minimizing the Error Gap in Smart Framing by Forecasting Production and Demand Using ARIMA Model

Agribusiness employs more than 66 percent of india’s rural population and is the country’s economic backbone.Beat crop growth is essential for practical farming since it increases soil diversity and actual design, and it may be grown in blended frameworks.Crop growth rates, applicability, and yields have not improved significantly over time in the united states.Crops are defined by their seasonality, derived nature of demand, and relatively inelastic pricing.The general purpose of this research is to demonstrate the usefulness of price forecasting for agricultural prices and validate it for rice, which is consumed more in indian states, for the year 2022, using time series data from 2016 to 2021.Every year, data for 50 days is collected and multiplied.The range of ten and its multiple is used for predicting.The results were obtained through the use of univariate analysis.To develop grain price estimates, researchers used autoregressive integrated moving average (arima) methods, and the precision of the forecasts was examined using conventional mean square error (mse) and mean absolute percentage error (mape) standards.As proven by the outcomes of arima price predictions, the arima model’s efficacy as a tool for price forecasting was effectively demonstrated by realistic models of projected prices for 2020.Because the msa and mape values were lower, the forecast was more accurate.In addition, the price forecasting in this model is dependent on government incentives.

Journal: Journal of Food Quality (2022)
Publication types: Research Article;
Measurement of Logistics Radiation Range and Improvement of Logistics Radiation Ability of City Clusters

The current development plans for logistics of city clusters often pursue investment speed, while overlooking the economic benefits of logistics within city clusters.To prevent the waste of logistics resources, it is meaningful to study the meaning of the logistics radiation ability of city clusters and determine their logistics radiation range.Taking ningbo metropolitan area as an example, this paper tries to measure logistics radiation range and improve logistics radiation ability of city clusters.The analytic hierarchy process (ahp) was adopted to quantify the logistics influencing factors.Besides, an improved breakpoint model was established based on the breakpoint theory, the logistics radiation range model, and the integrated logistics field theory.Drawing on the statistics in 2017, the improved model was applied to empirically measure the variation of integrated logistics quality of eight cities and determine the logistics radiation ranges of ningbo metropolitan area relative to shanghai metropolitan area and hangzhou metropolitan area.Finally, several countermeasures were developed to improve the logistics radiation ability of ningbo metropolitan area: the positioning of metropolitan areas, the model of logistics development, the development of industries closely associated with logistics, and the cultivation of strategic locational advantages.The research provides a good reference for the government of ningbo to develop advantageous logistics fields around advantages and turn the city into an economic center.

Journal: Discrete Dynamics in Nature and Society (2022)
Publication types: Research Article;
Machine Learning Model-Based Applications for Food Management in Alzheimer’s Using Regression Analysis Approach

Alzheimer’s disease (ad) has become a public health concern due to its misinterpretation with vascular dementia (vd) and mixed dementia alzheimer’s disease (mxd).Therefore, an accurate differentiation of these diseases is essential for improving the treatment procedure.It has been seen that nutrition along with several other factors plays a role in the disease progression.Scientists are trying to find a solution using some machine learning (ml) techniques.The ml algorithms used for this purpose are neural networks, support vector machines, regression and many more.The current research is focused on understanding the extent of the application of machine learning tools in enhancing food management for patients with alzheimer’s since there is no cure known for the same.A total of 100 patient data have been collected where the patients had ad, vd, and mxd.Their demographic data, dietary intake, fazekas scores, and hachinski scores were collected (independent variables) and analysed in ibm spss by considering the risk of development of ad, vd, and mxd as dependent variables.The findings showed that age is highly related ( p &lt; 0.001 ) to the development of these three diseases and other demographics are not prioritized.Discussion of other available journal articles showed that nutritional intake, fazekas scores, hachinski scores, and gender are also indicators for predicting these diseases ( p &lt; 0.001 ).Thus, this study concluded that age, gender, diet consumption, and fazekas and hachinski scores are important indicators for differentiating ad from other diseases, and ml can be used to create a custom nutrition plan based on the patient’s diet and stage of disease progression.Lastly, future scopes of ml have been explained in this paper.

Journal: Journal of Food Quality (2022)
Publication types: Research Article;
Long Noncoding RNA SAMMSON Promotes Melanoma Progression by Inhibiting FOXA2 Expression

Long noncoding rnas (lnc rnas) play crucial roles in melanoma initiation and development, serving as potential therapeutic targets and prognostic markers for melanoma.Lnc rna survival-associated mitochondrial melanoma-specific oncogenic noncoding rna (sammson) is upregulated in many types of human cancers.However, the functions of sammson in melanoma have not been fully elucidated.This study is aimed at investigating the expression and functions of sammson in melanoma development.Bioinformatics analysis was performed to determine the expression of sammson and its correlation with the 10-year overall survival (os) in melanoma patients.Cell proliferation, migration, invasion, and tumorigenesis were detected by mtt, colony formation, transwell assays, and mouse xenograft model.The expression of cell cycle-related factors, epithelial-to-mesenchymal transition (emt) makers, and matrix metalloproteinases (mmps) was assessed by rt-q pcr and western blotting analysis.The results demonstrated that sammson expression was upregulated in melanoma tissues and cells, and lower sammson expression was correlated with longer 10-year os.Sammson knockdown decreased the proliferation, migration, and invasion of melanoma cells by regulating the expression of proliferation-related genes, emt factors, and mmps, respectively.Additionally, forkhead box protein a2 (foxa2) was confirmed to be a target of sammson, and the biological effects induced by foxa2 overexpression were similar to those induced by sammson silencing in melanoma cells.Further studies showed that sammson downregulated foxa2 expression in melanoma cells by modulating the ezh2/h3k27me3 axis.Taken together, our data indicate that sammson plays an important role in melanoma progression and can be a valuable biomarker and therapeutic target in melanoma.

Journal: Stem Cells International (2023)
Publication types: Research Article;