syedzayyan/paper_mill_benchmark huggingface dataset:
Cell surface-anchored syndecan-1 ameliorates intestinal inflammation and neutrophil transmigration in ulcerative colitis.

Syndecan-1 (sdc1), with a variable ectodomain carrying heparan sulphate (hs) chains between different syndecans, participates in many steps of inflammatory responses.In the process of proteolysis, the hs chains of the complete extracellular domain can be shed from the cell surface, by which they can mediate most of sdc1's function.However, the exact impact on sdc1 which anchored on the cell surface has not been clearly reported.In our study, we established the models by transfection with the cleavable resistant sdc1 mutant plasmid, in which sdc1 shedding can be suppressed during stimulation.Role of membrane sdc1 in inflammatory pathway, pro-inflammatory cytokine secretion as well as neutrophil transmigration, and how suppressing its shedding will benefit colitis were further investigated.We found that the patients suffered ulcerative colitis had high serum sdc1 levels,presented with increased levels of p65, tumour necrosis factor alpha (tnf-α) and il-1β and higher circulating neutrophils.Nf-κb pathway was activated, and secretion of tnf-α, interleukin-1beta (il-1β), il-6 and il-8 were increased upon lipopolysaccharide stimuli in intestinal epithelial cells.Syndecan-1, via its anchored ectodomain, significantly lessened these up-regulation extents.It also functioned in inhibiting transmigration of neutrophils by decreasing cxcl-1 secretion.Moreover, sdc1 ameliorated colitis activity and improved histological disturbances of colon in mice.Taken together, we conclude that suppression of sdc1 shedding from intestinal epithelial cells relieves severity of intestinal inflammation and neutrophil transmigration by inactivating key inflammatory regulators nf-κb, and down-regulating pro-inflammatory cytokine expressions.These indicated that compenstion and shedding suppression of cytomembrane sdc1 might be the optional therapy for intestinal inflammation.

Journal: Journal of cellular and molecular medicine (2017)
Publication types: Journal Article
Aerobic exercise training prevents impairment in renal parameters and in body composition of rats fed a high sucrose diet.

This study aimed to evaluate the effect of swimming training (t) on the renal system and body composition parameters in young animals treated with a high sucrose diet (sud) during 12 weeks.Results the sud impaired the physical performance, increased the body adiposity index (bai), lee index (li) and retroperitoneal adipose tissue (rat) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance.The t reversed the increased the bai, li, rat weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion.This study found that eight weeks of swimming physical training protected renal function and restored normal glomerular filtration rate (gfr) values.Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by sud decreasing the body composition parameters (bai, li, and rat weight).

Journal: BMC research notes (2021)
Publication types: Journal Article
miR-4510 acts as a tumor suppressor in gastrointestinal stromal tumor by targeting APOC2.

Dysregulation of micro rnas (mi rnas) expression has been demonstrated in gastrointestinal stromal tumor (gist).In this study, we aimed to determine the differential mi rnas expression in gists and explore the functional mechanism of differential mi rnas in gist cells.We measured differential mi rnas in six pairs of gist tissues and matched adjacent tissues through a high-throughput sequencing, which was confirmed in 64 pairs of gist tissues and adjacent tissues by real-time polymerase chain reaction.We found that mi r-4510 expression was significantly downregulated in gist tissues compared to matched control tissues.Luciferase reporter assay identified apolipoprotein c-ii (apoc2) as a direct target of mi r-4510.Overexpression of mi r-4510 inhibited the m rna and protein expression of apoc2.In addition, overexpression of mi r-4510 suppressed gist cell proliferation, migration, and invasion.Overexpression of mi r-4510 also inhibited the phosphorylation of akt and erk1/2, reduced the expression of matrix metallopeptidase 2 (mmp2) and mmp9.Apoc2 knockdown mimicked the effect of mi r-4510 overexpression.Further investigation confirmed that apoc2 was notably upregulated in gist tissues compared to adjacent control tissues.These results suggested that mi r-4510 downregulation could promote gist progression, including growth, invasion, and metastasis, through increasing apoc2 expression.

Journal: Journal of cellular physiology (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Taking Time: A Mixed Methods Study of Parkinson's Disease Caregiver Participation in Activities in Relation to Their Wellbeing.

S although many studies have shown that psychosocial interventions, such as dance classes, can improve quality of life for people with parkinson's disease (pd): few have addressed the role of, and potential benefits to, the caregivers in such activities.This mixed methods study explored the reasons for caregiver participation in a variety of activities and considered whether participation in, or abstention from these, affected the wellbeing of the caregivers.Method transcriptions of a focus group (two people with pd, two caregivers) and eight semistructured interviews (caregivers) were analysed using grounded theory (gt).To test the hypotheses derived from the gt, caregivers (n= 75) completed an online survey about activities they and the person they care for participated in, alongside the pdq-carer questionnaire, to establish the caregiver's levels of wellbeing.Results qualitative findings suggested that caregivers tried to find a balance between caring for the person with pd and participating in activities to attend to their own needs.Reasons for participating in activities for people with pd included being able to socialise in an empathetic safe space, alongside engaging in physical activity that provided some respite distraction, such as dancing with others to music.Reasons for not participating included generating time for oneself and increasing the independence of the person with pd.Quantitative results suggested that most of the participants' wellbeing was not compromised, although this was gendered: female caregivers reported lower wellbeing scores than male caregivers.Overall, 62% of caregivers participated in joint activities.Linear regression revealed a significant relationship between nonparticipation in daily activities and stress levels for female caregivers only, whereby the more independent the person with pd was, the lower the stress of the caregiver.Conclusion this study suggests that caregivers of people with pd can find a healthy balance in terms of their own wellbeing by jointly participating in two-thirds of activities while ensuring the remaining third is time reserved for themselves.

Journal: Parkinson's disease (2020)
Publication types: Journal Article
Insight into the Synergistic Effect on Selective Adsorption for Heavy Metal Ions by a Polypyrrole/TiO2Composite.

Polymer/metal oxide composites are promising candidates for the treatment of water pollution.Adsorption selectivity as well as a large adsorption capacity are two key factors for treating wastewater containing multiple ions.Herein, a ppy+/ti o2(o-) composite with a heterojunction structure was first discovered to have novel selectivity toward heavy metal ions.An interesting self-doping nature of ti o2(o-) together with so42-for ppy+was reported.This interesting structure contributed to an impressive selective adsorption capability with an ascending order of zn2+> pb2+≫ cu2+in a ternary ion system, where the adsorption for cu2+could be almost suppressed.Through the designed adsorption experiments and characterization techniques including fourier transform infrared, thermogravimetric analysis, and x-ray photoelectron spectroscopy, a universal synergistic mechanism for ppy+/ti o2(o-) composite was first proposed and confirmed.The doping and dedoping of metal oxide (dopant) from the polymer dictates the adsorption selectivity, where the selectivity is determined by the interaction between ti o2and heavy metal ions.This work may provide some useful guidelines for designing adsorbents with selectivity toward specific heavy metal ions.

Journal: Langmuir : the ACS journal of surfaces and colloids (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
New insights on the analysis of phytosterols in pollen and anther wall of tree peony (Paeonia ostii 'Fengdan') revealed by GC-MS/MS.

Phytosterols exhibit a wide range of pharmacological activities and have no side-effects, which have attracted more and more attention.In this study, two pre-treatment methods (alkaline hydrolysis and acid-alkali hydrolysis) were performed in parallel for the first time to investigate the effects on phytosterol analysis.The aim is to develop an analytical method for phytosterols in pollen and anther wall of tree peony (paeonia ostii 'fengdan') by gas chromatography-mass spectrometry.The result indicated that the contents of phytosterols in pollen (3390.02 mg/100 g dw) and anther wall (929.70 mg/100 g dw) of p.Ostii 'fengdan' were relatively high.Meanwhile, eleven phytosterols were identified, among which five phytosterols were first identified in tree peony pollen.Moreover, the effects of wall breaking and different developmental stages on phytosterol contents of pollen and anther wall of p.Ostii 'fengdan' were also discussed.The result showed that wall breaking was beneficial to sterol detection of pollen, but not necessary for anther wall.For the best harvest time, the stage of s2 had the highest content of phytosterols.In conclusion, this study successfully establishes an analytical method for phytosterols by gas chromatography-mass spectrometry, and lays a foundation for the development and utilization of pollen and anther wall of p.Ostii 'fengdan' in functional foods and pharmaceutical industry.

Journal: Analytica chimica acta (2022)
Publication types: Journal Article
Advanced-stage cancer and time to diagnosis: An International Cancer Benchmarking Partnership (ICBP) cross-sectional study.

To investigate the relationship between tumour stage at diagnosis and selected components of primary and secondary care in the diagnostic interval for breast, colorectal, lung and ovarian cancers.Methods observational study based on data from 6,162 newly diagnosed symptomatic cancer patients from module 4 of the international cancer benchmarking partnership.We analysed the odds of advanced stage of cancer as a flexible function of the length of primary care interval (days from first presentation to referral) and secondary care interval (days from referral to diagnosis), respectively, using logistic regression with restricted cubic splines.Results the association between time intervals and stage was similar for each type of cancer.A statistically significant u-shaped association was seen between the secondary care interval and the diagnosis of advanced rather than localised cancer, odds decreasing from the first day onwards and increasing around three and a half months.A different pattern was seen for the primary care interval, flat trends for colorectal and lung cancers and a slightly curved association for ovarian cancer, although not statistically significant.Conclusion the results confirm previous findings that some cancers may progress even within the relatively short time frame of regulated diagnostic intervals.The study supports the current emphasis on expediting symptomatic diagnosis of cancer.

Journal: European journal of cancer care (2019)
Publication types: Journal Article;Observational Study
The clinical course of a 79-year-old stroke survivor in the setting of a late-onset COVID-19 infection.

Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (covid-19), no specific antiviral drug has been proven effective for the treatment of patients with severe complications.However, a nucleoside prodrug remdesivir (gs-5734) was recently approved by the food and drug administration for the treatment of hospitalized patients with covid-19.Preclinical data in animal models of coronavirus diseases have demonstrated that early treatment with remdesivir leads to improved survival and decreased lung injury.Recent clinical data have demonstrated the clinical activity of remdesivir in terms of shorter recovery period and higher odds of improved clinical status in patients with covid-19.Here, the story of a 79-year-old patient, with 11-year-old left hemiparesis, concomitant cardiovascular disease, infected with sars-co v-2, and the clinical improvement after administration of remdesivir during his second hospitalization period is reported.

Journal: SAGE open medical case reports (2022)
Publication types: Case Reports;Journal Article
Menopausal vasomotor symptoms and adiponectin among midlife women.

Vasomotor symptoms (vms) are prevalent symptoms that can have a negative impact on quality of life.Vms have also been linked to cardiovascular disease risk, yet the mechanisms underlying these associations have not been elucidated.Some initial works link vms to adverse adipokine profiles or cytokines produced by adipose tissue.However, results are not entirely consistent and are based entirely on self-report vms, which is influenced by a range of memory and reporting biases.The aim of this work was to test whether physiologically assessed vms are associated with lower adiponectin, the most abundant adipokine in the body, controlling for confounding factors.We also consider whether adiponectin explains previously documented relationships between vms and carotid atherosclerosis.Methods a total of 300 peri- and postmenopausal nonsmoking women aged 40 to 60 years enrolled in the ms heart study comprised the analytic sample.Women were free of hormone therapy or other medications impacting vms, insulin-dependent diabetes, and cardiovascular disease.Participants underwent ambulatory physiologic vms monitoring, physical measures, a carotid ultrasound, and fasting phlebotomy.Results more frequent physiologically assessed vms were associated with lower adiponectin ( b [se] = -0.081 [0.028], p = 0.004; or 0.081 lower μg/m l in adiponectin for each additional vms over 24 hours), controlling for age, race/ethnicity, education, insulin resistance, and waist circumference.Associations were not explained by endogenous estradiol.Adiponectin did not explain associations between vms and carotid atherosclerosis.Conclusions physiologic vms were associated with lower adiponectin after considering potential confounders.The role of adipokines in vms and in links between vms and health warrants further attention.

Journal: Menopause (New York, N.Y.) (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
The Prevalence of Uncontrolled Hypertension among Patients Taking Antihypertensive Medications and the Associated Risk Factors in North Palestine: A Cross-Sectional Study.

Uncontrolled hypertension (htn) is a challenge for public health professionals all over the world.It is the leading and most important modifiable risk factor for coronary artery disease, congestive heart failure, stroke, renal diseases, and retinopathy.The aim of the present study was to estimate the prevalence of uncontrolled htn among palestinian hypertensive patients on treatment.In addition, the study aimed to explore the relationship between socio-demographic and clinical factors with htn control as well as establish a comprehensive literature review for similar studies.Methods a cross-sectional study was conducted.218 hypertensive patients who met the inclusion criteria were included in the study.Results htn is not adequately controlled in over 60% of treated patients.Factors that were linked to uncontrolled htn and were statistically significant as per this study were diabetes (p=0.010), high bmi (p=0.009), smoking (p< 0.0001), lower educational level (p=0.002), and monotherapy (p=0.004).Conclusion the results suggest that effective efforts on improving htn control are strongly needed.The efforts need to target hypertensive patients who are also smokers, diabetics, having a low education level, and have a higher-than-normal bmi.

Journal: Advances in medicine (2022)
Publication types: Journal Article
Anaphylaxis and Pregnancy: A Systematic Review and Call for Public Health Actions.

Although rare, anaphylaxis during pregnancy implies a risk to both mothers and newborns.Objective this systematic review is intended to identify key issues in the diagnosis and management of this condition to support prevention strategies and decrease the risk for death related to anaphylaxis during pregnancy.Methods we searched medline, cochrane, lilacs, sci elo, and science direct databases for manuscripts concerning the term "anaphylaxis during pregnancy," without language restrictions.We screened studies, extracted data, and assessed the risk for bias independently in duplicate.Results we selected 12 articles.Frequency of anaphylaxis during maternity was estimated to be 1.5 to 3.8 per 100,000 pregnancies.Only one study provided anaphylaxis mortality data in pregnant women; the rate of anaphylaxis-related maternal mortality was estimated at 0.05/100,000 live births.No standard definition of anaphylaxis severity has been used.A total of 49% to 74% of anaphylaxis cases were described during caesarean section.Beta-lactam antibiotics (58%), latex (25%), and anesthetic agents (17%) were the main causes.In 17% of reports, causative agents were proven by allergy testing.Moreover, 72% of articles proposed the same management and treatment for a clinical episode of anaphylaxis during pregnancy as for nonpregnant patients, and the use of epinephrine in the patient's care during anaphylaxis in pregnancy.Conclusions few studies address anaphylaxis during pregnancy.Most have been produced by nonallergy specialists.Collaboration among different specialists involved in the care of pregnant women should be established to support preventive strategies and reduce avoidable deaths.

Journal: The journal of allergy and clinical immunology. In practice (2021)
Publication types: Journal Article;Systematic Review
Inflammatory Bowel Diseases and Food Additives: To Add Fuel on the Flames!

Inflammatory bowel diseases (ibds) develop in genetically predisposed individuals in response to environmental factors.Ibds are concomitant conditions of industrialized societies, and diet is a potential culprit.Consumption of ultra-processed food has increased over the last decade in industrialized countries, and epidemiological studies have found associations between ultra-processed food consumption and chronic diseases.Further studies are now required to identify the potential culprit in ultra-processed food, such as a poor nutritional composition or the presence of food additives.In our review, we will focus on food additives, i.e., substances from packaging in contact with food, and compounds formed during production, processing, and storage.A literature search using pub med from inception to january 2019 was performed to identify relevant studies on diet and/or food additive and their role in ibds.Manuscripts published in english from basic science, epidemiological studies, or clinical trials were selected and reviewed.We found numerous experimental studies highlighting the key role of food additives in ibd exacerbation but epidemiological studies on food additives on ibd risk are still limited.As diet is a modifiable environmental risk factor, this may offer a scientific rationale for providing dietary advice for ibd patients.

Journal: Nutrients (2019)
Publication types: Journal Article;Review
Appropriateness of psychiatric advance directives facilitated by peer support specialists and clinicians on Assertive Community Treatment teams.

Psychiatric advance directives (pads) are used to document a person's treatment preferences for a future mental health crisis.Peer support specialists have been proposed to facilitate pads, but little is known about the quality of peer versus clinician facilitated pads.Aims this study examined whether pad documents facilitated by peer specialists and non-peer clinicians differed in the mix of treatment requests and refusals and expert ratings of feasibility and consistency.Methods analyses were conducted of content and expert ratings of 72 pad documents from a randomized trial of pad facilitation by peers and clinicians on assertive community treatment (act) teams.A count of treatment refusals and requests was used to classify documents as predominantly prescriptive, proscriptive, or balanced.Regression was used to estimate relationships between pad facilitator type and content.Results peer-facilitated pads were significantly more likely to be predominantly prescriptive than were pads facilitated by non-peer clinicians.Prescriptive pads were more likely to receive expert ratings of high feasibility and consistency.Conclusions results should alleviate some clinicians' apprehensions regarding the appropriateness of peer-facilitated pads, such as the concern that people with lived experience with mental illness might encourage other consumers to use their pad primarily for treatment refusals.

Journal: Journal of mental health (Abingdon, England) (2022)
Publication types: Journal Article
Swelled Mechanism of Crumb Rubber and Technical Properties of Crumb Rubber Modified Bitumen.

Crumb rubber modified bitumen (crmb) has excellent high-temperature performance and fatigue resistance, and is widely used in asphalt pavement to cope with increasing traffic axle load and changing climate.Under conventional preparation conditions, the swelling degree of cr can directly impact the comprehensive properties of crmb; however, physical and chemical properties research on swelling crumb rubber (scr) and crumb rubber recycled bitumen (crrb) in crmb is relatively lacking.In this paper, the working performance of crmb and crrb in high-temperature and low-temperature conditions were studied through physical and working performance testing of bitumen.The cr and scr were tested by scanning electron microscope (sem), fourier transform infrared spectrometer (ftir), gel permeation chromatography (gpc), and particle size distribution (psd) tests to study the physicochemical behavior and microscopic effects before and after cr swelling.The results showed that cr dosage was in the range of 10%, 15%, and 20%, as well as that cr dosages have a positive effect on the high- and low-temperature performance, storage stability, and elastic recovery of bitumen.The high-temperature pg grades of bitumen were directly improved by four grades, and the elastic recovery rate increased by 339.9%.Cr improved the ultra-low temperature crack resistance of bitumen.Due to the absorption of lighter components by cr, the relative content of the heavy component of bitumen increased; however, its low-temperature performance decreased significantly.After swelling, the cr particle size increased and the range became wider, the surface complexity of cr became higher, and the specific surface area was larger.At the same time, cr carried out the transformation process from large and medium molecules to small molecules.During the swelling process, a new benzene ring structure appeared in the cr, and the c-c bond and c-s bond of cr broke, forming part of the c=c bond.

Journal: Materials (Basel, Switzerland) (2022)
Publication types: Journal Article