syedzayyan/paper_mill_benchmark huggingface dataset:
Misleading estimates of economic impacts of biological invasions: Including the costs but not the benefits.

The economic costs of non-indigenous species (nis) are a key factor for the allocation of efforts and resources to eradicate or control baneful invasions.Their assessments are challenging, but most suffer from major flaws.Among the most important are the following: (1) the inclusion of actual damage costs together with various ancillary expenditures which may or may not be indicative of the real economic damage due to nis; (2) the inclusion of the costs of unnecessary or counterproductive control initiatives; (3) the inclusion of controversial nis-related costs whose economic impacts are questionable; (4) the assessment of the negative impacts only, ignoring the positive ones that most nis have on the economy, either directly or through their ecosystem services.Such estimates necessarily arrive at negative and often highly inflated values, do not reflect the net damage and economic losses due to nis, and can significantly misguide management and resource allocation decisions.We recommend an approach based on holistic costs and benefits that are assessed using likely scenarios and their counter-factual.

Journal: Ambio (2022)
Publication types: Journal Article;Review
Membrane-associated cytoplasmic granules carrying the Argonaute protein WAGO-3 enable paternal epigenetic inheritance in Caenorhabditis elegans.

Epigenetic inheritance describes the transmission of gene regulatory information across generations without altering dna sequences, enabling offspring to adapt to environmental conditions.Small rnas have been implicated in this, through both the oocyte and the sperm.However, as much of the cellular content is extruded during spermatogenesis, it is unclear whether cytoplasmic small rnas can contribute to epigenetic inheritance through sperm.Here we identify a sperm-specific germ granule, termed the paternal epigenetic inheritance (pei) granule, that mediates paternal epigenetic inheritance by retaining the cytoplasmic argonaute protein wago-3 during spermatogenesis in caenorhabditis elegans.We identify the pei granule proteins pei-1 and pei-2, which have distinct functions in this process: granule formation, argonaute selectivity and subcellular localization.We show that pei granule segregation is coupled to the transport of sperm-specific secretory vesicles through pei-2 in an s-palmitoylation-dependent manner.Pei-like proteins are found in humans, suggesting that the identified mechanism may be conserved.

Journal: Nature cell biology (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Video-Audio Media
Ethical Considerations in Surgical Decompression for Stroke.

Stroke is a major cause of morbidity and mortality.Neurosurgical decompression is often considered for the treatment of malignant infarcts and intraparenchymal hemorrhages, but this treatment can be frought with ethical dilemmas.In this article, the authors outline the primary principles of bioethics and their application to stroke care, provide an overview of key ethical issues and special situations in the neurosurgical management of stroke, and highlight methods to improve ethical decision-making for patients with stroke.Understanding these ethical principles is essential for stroke care teams to deliver appropriate, timely, and ethical care to patients with stroke.

Journal: Stroke (2022)
Publication types: Journal Article;Review
SORL1 Polymorphisms in Mexican Patients with Alzheimer's Disease.

The present study evaluated the risk effect of 12 single nucleotide polymorphisms in the sorl1 gene in the mexican population using late-onset alzheimer's disease (load) and control subjects.Considering apoe as the strongest genetic risk factor for load, we conducted interaction analyses between single nucleotide polymorphisms (snps) and the apoe genotype.Methods patients were interviewed during their scheduled visits at neurologic and geriatric clinics from different institutions.The load diagnosis included neurological, geriatric, and psychiatric examinations, as well as the medical history and neuroimaging.Polymorphisms in sorl1were genotyped by real-time pcr in 156 subjects with load and 221 controls.Apoe genotype was determined in each study subject.Allelic, genotypic, and haplotypic frequencies were analyzed; an ancestry analysis was also performed.Results the a/a genotype in rs1784933 might be associated with an increased load risk.Two blocks with high degree linkage disequilibrium (ld) were identified.The first block composed by the genetic variants rs668387, rs689021 and rs641120 showed a positive interaction (mainly the rs689021) with rs1784933 polymorphism.Moreover, we found a significant association between the apoeε4 allele carriers and the variant rs2070045 located in the second ld block.Conclusion the rs1784933 polymorphism is associated with load in mexican patients.In addition, the presence of apoeε4 allele and sorl1 variants could represent a genetic interaction effect that favors load risk in the mexican population.Snps have been proposed as genetic markers associated with the development of load that can support the clinical diagnosis.Future molecular studies could help understand sporadic alzheimer's disease (ad) among the mexican population, where currently there is a sub-estimate number in terms of disease frequency and incidence.

Journal: Genes (2022)
Publication types: Journal Article
Immune checkpoint inhibitor-induced myositis, the earliest and most lethal complication among rheumatic and musculoskeletal toxicities.

In addition to restoring anti-tumor immune responses, immune checkpoint inhibitors (ici) may also induce immune-related adverse events (ir ae) that can affect any organ.We aim to determine the spectrum, timing, clinical features, and fatalities of rheumatic and musculoskeletal immune-related adverse events (rms-ir ae) associated with ici.Patients methods we performed an observational, retrospective, pharmacovigilance study using the world health organization international pharmacovigilance database, vigi base, from inception to january 2019.Rms-ir ae reporting rate on ici versus full database was performed using disproportionality analysis with computation of reporting-odds-ratios (ror) and a bayesian disproportional estimate (information component, ic).Ic025(lower end of the ic 95% credibility interval) >0 is deemed significant.Results we identified 1288 rms-ir ae significantly associated with ici: polymyalgia rheumatica (n = 76, ror = 14.6 [11.6-18.4], ic025= 3.34), sarcoidosis (n = 94; ror = 9.6 [7.9-11.9]; ic025= 2.85), sjogren's syndrome (n = 49; ror = 6.9 [5.2-9.2]; ic025= 2.24), myositis (n = 465; ror = 4.9 [4.5-5.4]; ic025= 2.12), arthritis (n = 606; ror = 1.4 [1.3-1.5]; ic025= 0.34) and scleroderma (n = 17; ror = 2.0 [1.2-3.2]; ic025= 0.17).Arthritis, myositis, and sjogren's syndrome were over-reported in patients treated with ici combination versus those treated with ici monotherapy (ror = 1.6-2.9, p < .05) and more frequently reported on anti-pd1/pdl1 monotherapy vs.Anti-ctla4 monotherapy (2.1-4.4, p < .05).Median time to onset occurred early for myositis (31 days [19.2-57.8]) and was the most delayed for scleroderma (395 days [323.8-457.2], p < .0001).The fatality rate for rms-ir ae ranged from 24% for myositis (n = 106/441) (up to 56.7% with concurrent myocarditis) to [0-6.7%] for other rms-ir ae (p < .0001).Conclusions clinicians should be aware of the spectrum of rms-ir ae.Myositis can be particularly life-threatening, particularly when associated with myocarditis.

Journal: Autoimmunity reviews (2020)
Publication types: Journal Article;Observational Study
Increase in Mitochondrial D-Loop Region Methylation Levels in Mild Cognitive Impairment Individuals.

Methylation levels of the mitochondrial displacement loop (d-loop) region have been reported to be altered in the brain and blood of alzheimer's disease (ad) patients.Moreover, a dynamic d-loop methylation pattern was observed in the brain of transgenic ad mice along with disease progression.However, investigations on the blood cells of ad patients in the prodromal phases of the disease have not been performed so far.The aim of this study was to analyze d-loop methylation levels by means of the ms-hrm technique in the peripheral blood cells of 14 mild cognitive impairment (mci) patients, 18 early stage ad patients, 70 advanced stage ad patients, and 105 healthy control subjects.We found higher d-loop methylation levels in mci patients than in control subjects and ad patients.Moreover, higher d-loop methylation levels were observed in control subjects than in ad patients in advanced stages of the disease, but not in those at early stages.The present pilot study shows that peripheral d-loop methylation levels differ in patients at different stages of ad pathology, suggesting that further studies deserve to be performed in order to validate the usefulness of d-loop methylation analysis as a peripheral biomarker for the early detection of ad.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article
Identify the role of Human Wharton's Jelly Mesenchymal Stem Cells in repairing injured uterine of rat.

Maternal complications caused by the cesarean delivery inhibit the capability of preserving the uterus and subsequent fertility.However, successful restoration of the incisional scar continuously still remains a challenge.This work was to evaluate the repairing effect of human wharton's jelly mesenchymal stem cells (h wj-msc) on incisional scar of the uterine.Methods eighteen rats were randomly assigned into two groups and nine for each: one group injected with h wj-msc in phosphate buffer saline (pbs) and the other injected with pbs for comparison.Results with h wj-msc in pbs injected, the uterine endometrium and myometrium with full-thickness injury were restored and the functionality was greatly improved in comparison with the group only with pbs injected.Conclusion the h wj-msc can repair the injured uterine effectively by promoting the uterine endometrium and myometrium cells proliferation and according to the chi-square analysis the pregnancy is improved.

Journal: The journal of obstetrics and gynaecology research (2021)
Publication types: Journal Article
Successful use of VV ECMO in managing negative pressure pulmonary edema.

The indications for extracorporeal membrane oxygenation (ecmo) are expanding.Postobstructive pulmonary edema, also known as negative pressure pulmonary edema, can result in severe respiratory compromise and acute respiratory distress syndrome.We present a case of a 26-year-old female with laryngeal papillomatosis and laryngospasm after direct laryngoscopy, who developed severe nppe refractory to mechanical ventilator support, which was successfully treated with veno-venous ecmo.

Journal: Journal of cardiac surgery (2020)
Publication types: Case Reports;Journal Article
Changes in Biomarkers of Tobacco Exposure among Cigarette Smokers Transitioning to ENDS Use: The Population Assessment of Tobacco and Health Study, 2013-2015.

Limited data are available for how biomarkers of tobacco exposure (boe) change when cigarette smokers transition to using electronic nicotine delivery systems (ends).Using biomarker data from waves 1 (2013-2014) and 2 (2014-2015) of the path study, we examined how mean boe concentrations, including metabolites of nicotine, tobacco-specific nitrosamines (tsna), polycyclic aromatic hydrocarbons (pah), and volatile organic compounds (voc) and metals, changed when 2475 adult smokers transitioned to using ends or quit tobacco products.Exclusive smokers who transitioned to dual use had a significant decrease in nnal (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol), but not nicotine metabolites, most pahs, metals, or vocs.Exclusive smokers who became dual users had significant reductions in total nicotine equivalents, nnal, and 2cy ema (acrylonitrile metabolite), but only in those who reduced cigarettes per day (cpd) by >=50%.Smokers who transitioned to exclusive ends use had significant reductions in most tsnas, pahs, and vocs; however, nicotine metabolites did not decrease in dual users who became exclusive ends users.Smokers who quit tobacco use had significant decreases in nicotine metabolites, all tsnas, most pahs, and most vocs.Cigarette smokers who became dual users did not experience significant reductions in most boes.Reductions were impacted by changes in cpd.However, transitioning from smoking to no tobacco or exclusive ends use was associated with reduced exposure to most boes measured.Future analyses could incorporate additional waves of path data and examine changes in biomarker exposure by ends device type and cpd.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, P.H.S.
Wood-Splitter-Related Upper-Limb Injuries: A Single-Centered Case-Series Study.

(1) background: injuries to the upper limbs during wood splitting can affect social and economic life.We aimed to describe the clinical information concerning these injuries in japan.(2) methods: we identified patients from our patient database from april 2015-november 2021 and extracted data from their medical records, which includes age, gender, occupation, month, time and location of the injury, diagnosis, duration of hospitalization, icu admission, treatment interventions including surgery, outcome, and medical costs.(3) result: seventeen cases were identified.Most of the patients were male (n= 15), with median age being 68 years old.Regarding the patients' backgrounds, six were apple farmers and three were unemployed.Injuries to the index finger was most common (n= 9), followed by injuries to the thumb in five cases (n= 5).Most of the incidents occurred at home or on the patient's farm estate.No injuries were due to incidents at work.(4) conclusion: the wood splitter-related injuries required long-term treatment and frequently damaged the thumb, a functionally important digit.All the injuries were sustained during non-occupational use of a wood splitter.Therefore, we suggest that safety training should be provided to prevent traumatic injuries when these products are being sold.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article
Birth weight curves of twin neonates with a gestational age of 25-40 weeks and their regional differences in 11 cities of China: an analysis of 17 256 cases.

S to develop the birth weight curve of twin neonates with a gestational age of 25-40 weeks, and to investigate the regional differences of the birth weight curve.Methods a total of 11 maternal and child health care hospitals with more than 7 000 neonates delivered annually were selected in 11 cities of china (haikou, guangzhou, liuzhou, guilin, quanzhou, shenzhen, chongqing, chengdu, changsha, ningbo, and lianyungang), and all live twin neonates delivered in the 11 hospitals from january 1, 2017 to december 31, 2020 were enrolled for the development of birth weight curves.Results a total of 17 256 twin neonates with a gestational age of 25-40 weeks from the 11 cities were included in the study.The reference values of the 3rd-97th percentiles of birth weight of twin neonates for the total of the 11 cities and for each of the 11 cities in china were established, and the birth weight percentile curves were drawn.The birth weight curve level of twin neonates in liuzhou was lower than the average level of the 11 cities; the birth weight curve level of twin neonates in ningbo was higher than the average level of the 11 cities; the birth weight curve level of twin neonates in lianyungang was obviously higher than the average level of the 11 cities; the birth weight curve level of twin neonates in other 8 cities was almost the same as the average level of the 11 cities.Conclusions the reference values of the 3rd-97th percentiles of birth weight of twin neonates for the total of the 11 cities and for each of the 11 cities are developed, which can be used as a reference for evaluating the intrauterine growth of twin neonates in the region.The level of intrauterine growth of twin neonates in some cities is different from the average level of the 11 cities of china.

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics (2022)
Publication types: Journal Article
Uterine artery chemoembolization followed by hysteroscopic resection for management of retained placenta accreta with marked vascularity after evacuation of first-trimester miscarriage in angular pregnancy: A case report.

Angular pregnancy is a rare form of eccentric intrauterine gestation.To determine the management strategy, angular pregnancy should be differentiated from interstitial pregnancy and cornual pregnancy.Case a 37-year-old woman (gravida 5, para 4) with no previous disease history was referred because of a retained placenta with hemorrhage 20 days following the manual vacuum aspiration of an intrauterine pregnancy performed after the diagnosis of miscarriage at 8 weeks of gestation.At the initial examination, a prominent vascular mass was identified in the left lateral portion of the uterus.The patient's serum β-human chorionic gonadotropin level was 1949 iu/l.Magnetic resonance imaging revealed an enlarged angular space occupied by a suspected retained placenta with expansion of the surrounding myometrium.Three-dimensional computerized tomography showed a prominent vascular mass with a feeding left uterine artery and draining thick left ovarian vein.The diagnosis consisted of retained placenta accreta with marked vascularity after evacuation of a miscarriage in a woman with angular pregnancy.Uterine artery chemoembolization was performed followed by the administration of a single dose of systemic methotrexate.Because the gestational mass persisted and spontaneous expulsion appeared to be unlikely, despite the gradual decline of serum β-human chorionic gonadotropin levels, hysteroscopic resection of the retained placenta was performed and the patient's subsequent recovery was uneventful.

Journal: Case reports in women's health (2021)
Publication types: Case Reports;Journal Article
Decreased Mortality Over Time During the First Wave in Patients With COVID-19 in Geriatric Care: Data From the Stockholm GeroCovid Study.

To describe temporal changes in treatment, care, and short-term mortality outcomes of geriatric patients during the first wave of the covid-19 pandemic.Design observational study.Setting and participants altogether 1785 patients diagnosed with covid-19 and 6744 hospitalized for non-covid-19 causes at 7 geriatric clinics in stockholm from march 6 to july 31, 2020, were included.Methods across admission month, patient vital signs and pharmacological treatment in relationship to risk for in-hospital death were analyzed using the poisson regression model.Incidence rates (irs) and incidence rate ratios (irrs) of death are presented.Results in patients with covid-19, the ir of mortality were 27%, 17%, 10%, 8%, and 2% from march to july, respectively, after standardization for demographics and vital signs.Compared with patients admitted in march, the risk of in-hospital death decreased by 29% [irr 0.71, 95% confidence interval (ci) 0.51-0.99] in april, 61% (0.39, 0.26-0.58) in may, 68% (0.32, 0.19-0.55) in june, and 86% (0.14, 0.03-0.58) in july.The proportion of patients admitted for geriatric care with oxygen saturation <90% decreased from 13% to 1%, which partly explains the improvement of covid-19 patient survival.In non-covid-19 patients during the pandemic, mortality rates remained relatively stable (ir 1.3%-2.3%).Compared with non-covid-19 geriatric patients, the irr of death declined from 11 times higher (irr 11.7, 95% ci 6.11-22.3) to 1.6 times (2.61, 0.50-13.7) between march and july in patients with covid-19.Conclusions and implications mortality risk in geriatric patients from the stockholm region declined over time throughout the first pandemic wave of covid-19.The improved survival rate over time was only partly related to improvement in saturation status at the admission of the patients hospitalized later throughout the pandemic.Lower incidence during the later months could have led to less severe hospitalized cases driving down mortality.

Journal: Journal of the American Medical Directors Association (2021)
Publication types: Journal Article;Observational Study
Abscisic Acid (ABA ) Promotes the Induction and Maintenance of Pear (Pyrus pyrifolia White Pear Group) Flower Bud Endodormancy.

Dormancy is an adaptive mechanism that allows temperate deciduous plants to survive unfavorable winter conditions.In the present work, we investigated the possible function of abscisic acid (aba) on the endodormancy process in pear.The aba content increased during pear flower bud endodormancy establishment and decreased towards endodormancy release.In total, 39 putative genes related to aba metabolism and signal transductions were identified from pear genome.During the para- to endodormancy transition,pp nced-2and pp nced-3had high expression levels, while pp cyp707as expression levels were low.However, during endodormancy, the expression of pp cyp707a-3sharply increased with increasing cold accumulation.At the same time, the aba content of pear buds declined, and the percentage of bud breaks rapidly increased.On the other hand, the expression levels of pp pyls,pp pp2cs,pp sn rk2s, and pp abi4/abi5s were also changed during the pear flower bud dormancy cycle.Furthermore, exogenous aba application to para-dormant buds significantly reduced the bud breaks and accelerated the transition to endodormancy.During the whole treatment time, the expression level of pp pp2c-12decreased to a greater extent in aba-treated buds than in control.However, the expression levels of pp sn rk2-1,pp sn rk2-4, and pp abi5-1were higher in aba-treated buds.Our results indicated that pp cyp707a-3and pp nceds play pivotal roles on the regulation of endodormancy release, while aba signal transduction pathway also appears to be involved in the process.The present work provided the basic information about the function of aba-related genes during pear flower bud dormancy process.

Journal: International journal of molecular sciences (2018)
Publication types: Journal Article