syedzayyan/paper_mill_benchmark huggingface dataset:
Asbestos exposure as an additional risk factor for small duct intrahepatic cholangiocarcinoma: a pilot study.

Intrahepatic cholangiocarcinoma (i cca) is a rare malignancy, recently classified in small duct and large duct morphological subtypes.Growing evidence suggests asbestos as a putative risk factor for i cca, albeit no correlation between asbestos and i cca morphology has been investigated so far.The aim of the present study was to assess the relationship between asbestos exposure and i cca morphological subtype.Forty patients with surgically removed i cca were prospectively enrolled: asbestos exposure was assessed according to the italian national mesothelioma register questionnaire.From the surgical i cca specimens the main histopathological variables were collected, including the small duct (sd-i cca, 32 patients) and large duct subtypes (ld-i cca, 8 patients).Five sd-i cca cases had a definite/probable occupational exposure to asbestos, while no cases of ld-i cca were classified as being occupationally exposed (definite/probable).Other kind of asbestos exposure (i.e.Possible occupational, familial, environmental) were recorded in 16 sd-i cca and 3 ld-i cca.Cases with unlikely exposure to asbestos were 11 sd-i cca (35.5%) and 5 ld-i cca (62.5%).In conclusion, these findings seem to indicate that sd-i cca might be more frequently associated to asbestos exposure rather than ld-i cca, suggesting that asbestos fibres might represent a parenchymal, rather than a ductal risk factor for i cca.This pilot study must be confirmed by further case-control studies or large independent cohorts.

Journal: Scientific reports (2023)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Transcervical Versus Transfemoral Approach in Carotid Stenting Real World Experience in a Community Hospital.

Introduction peri-procedural embolic events are the achilles' heel of carotid stenting.To overcome this complication, transcervical access to the carotid artery was introduced.In this study we describe our "our life" experience with the transcervical approach in a community hospital.Material and methods all carotid stent procedures between january 2010 and december 2020 were included in this retrospective analysis.The transcervical approach was compared to the transfemoral approach.In both procedures open-cell, closed-cell design and hybrid stents were used.In-hospital stroke was the primary outcome measure.Results a total of 340 procedures were performed, in 184 patients the transfemoral approach was used and in 156 patients the transcervical approach was used.In 12 patients (3.5%) an in-hospital stroke was diagnosed, 4 in the transfemoral group (2.2%) and 8 in the transcervical group (5.1%) (p = 0.14).In the multivariate analyses a symptomatic lesion was associated with in-hospital stroke.Neither type of access nor cell design was associated with increased risk of in-hospital stroke.Conclusions in contrast to previous studies, we could not confirm the advantages of the transcervical approach.However, conclusions should be carefully drawn, since this study is retrospective and was performed with multiple surgeon and different kind of stents.

Journal: Annals of vascular surgery (2022)
Publication types: Comparative Study;Journal Article
3D fat-suppressed T1-weighted volume isotropic turbo spin-echo acquisition (VISTA) imaging for the evaluation of the ectopic posterior pituitary gland.

We evaluated the usefulness of fat-suppressed three-dimensional t1-weighted volume isotropic turbo spin-echo acquisition (fs 3d t1w-vista) imaging for the evaluation of the ectopic posterior pituitary gland (eppg).Materials and methods this retrospective study included 9 patients with eppg due to causes other than tumor.All underwent sagittal two-dimensional (2d) t1w-, fs 3d t1w-vista- (vista), and 3d t2w-driven equilibrium radiofrequency reset pulse (drive) imaging.Two radiologists independently reviewed the 2d t1w- and vista images for their image quality and for visualization of the eppg and of pituitary stalk transection.Drive findings were used as the reference standard for pituitary stalk transection.Interobserver and intermodality agreements were evaluated with the kappa (κ) coefficient.The mean grade assigned to the 2d t1w- and the vista imaging technique for visualization of the eppg was assessed by the mann-whitney u test.Results interobserver agreement for visualization of the eppg on 2d t1w- and vista images was excellent (κ = 0.82 and κ = 1.00, respectively).The mean grade for eppg visualization was significantly higher for vista- than 2d t1w images (p = 0.0039).Conclusion fs 3d t1w-vista imaging is useful for the evaluation of eppg.Conventional mri yields insufficient information for the evaluation of the ectopic posterior pituitary gland (eppg).The visualization of the eppg was significantly higher for fat-suppressed three-dimensional t1-weighted volume isotropic turbo spin-echo acquisition (fs 3d t1w-vista) than 2d t1w images.Fs 3d t1w-vista imaging is useful for the evaluation of the eppg.

Journal: Japanese journal of radiology (2021)
Publication types: Journal Article
Pooled outcomes of performing freehand transperineal prostate biopsy with the PrecisionPoint Transperineal Access System.

S to report the results of a pooled analysis evaluating the cancer detection rates, complications, and tolerability of prostate biopsies performed using the precision point transperineal access system.Patients and methods the medical literature was reviewed to identify studies published prior to 1 october 2021 evaluating the precision point device for performance of transperineal prostate biopsy.Pooled analyses were performed to assess overall and clinically significant cancer detection rates.Additionally, data on complications as well as patient tolerability of the procedure when performed under local anaesthesia were extracted.Results transperineal biopsy with the precision point transperineal access system achieved overall and clinically significant cancer detection rates of 67.9% and 42.6%, respectively.Among patients with prostate imaging reporting and data system 3, 4, and 5 lesions on prostate magnetic resonance imaging, clinically significant disease was found in 31.7%, 55.7%, and 71.8% of patients, respectively.Complications were rare, with sepsis reported in 4 (0.1%) of 3411 procedures despite frequent omission of antibiotic prophylaxis.Patients reported acceptable tolerability of the procedure when performed under local anaesthesia.Conclusions within the available medical literature, there is uniform evidence supporting the use of the precision point transperineal access system for performing prostate biopsy procedures.The reported cancer detection and infectious complication rates with this device are in line with other methods for performing transperineal prostate biopsy.A unique aspect of the precision point device is its ability to facilitate performing transperineal prostate biopsy under local anaesthesia.This factor will likely lead to increased adoption of the beneficial transperineal approach to prostate biopsy.

Journal: BJUI compass (2022)
Publication types: Journal Article;Review
Graft-versus-host disease-associated angiomatosis with striking lipomatous metaplasia.

Sclerodermatous graft-versus-host disease (gv hd) is one of the many clinicopathological variants of chronic gv hd.One of the rarest forms of this variant is gv hd-associated angiomatosis (gv hd-aa).We describe the case of a 62-year-old male with sclerodermatous gv hd who presented, in consecutive years, two different lesions that showed characteristics of gv hd-aa.The first lesion fitted perfectly with the previously known features of this rare entity.However, the second lesion was more interesting, as the angiomatoid lesion was surrounded by newly appeared adipocytes, something not previously described.The appearance of this peculiar adipose tissue may be explained as related to an important dermal atrophy, as a concomitant appearance of a lipomatous nevus and gv hd-aa, or, finally, as mature adipose tissue related to a previous inflammatory process, that is, lipomatous metaplasia.Both lesions were diagnosed as gv hd-aa, and the second one was considered to be associated with dermal lipomatous metaplasia.We also considered whether hypoxia could be related to both lesions.In the present report, we review previously published cases of gv hd-aa and discuss the different hypotheses that could explain the appearance of metaplasia associated with the second lesion.

Journal: Journal of cutaneous pathology (2022)
Publication types: Case Reports;Journal Article
Evaluation of a high resolution diode array for CyberKnife quality assurance.

The cyber knife quality assurance (qa) program relies mainly on the use of radiochromic film (rcf).We aimed at evaluating high-resolution arrays of detectors as an alternative to films for cyber knife machine qa.Methods this study will test the srs mapcheck (sun nuclear, melbourne, florida, usa) diode array and its own software, which allows three tests of the cyber knife qa program to be performed.The first one is a geometrical accuracy test based on the delivery of two orthogonal beams (automated quality assurance, aqa).Besides comparing the constancy and repeatability of both methods, known errors will be introduced to check their sensitivity.The second checks the constancy of the iris collimator field sizes (iris qa).Changes in the field sizes will be introduced to study the array sensitivity.The last test checks the correct positioning of the multileaf collimator (mlc).It will be tested introducing known systematic displacements to whole banks and to single leaves.Results the results of the rcf and diode array were equivalent (maximum differences of 0.18 ± 0.14 mm) for the aqa test, showing the array a higher reproducibility.When known errors were introduced, both methods behaved linearly with similar slopes.Regarding iris qa, the array measurements are highly linear when changes in the field sizes are introduced.Linear regressions show slopes of 0.96-1.17 with r2above 0.99 in all field sizes.Diode array seems to detect changes of 0.1 mm.In mlc qa, systematic errors of the whole bank of leaves were not detected by the array, while single leaf errors were detected.Conclusions the diode array is sensitive and accurate in the aqa and iris qa tests, which give us the possibility of substituting rcf with a diode array.Qa would be performed faster than using the film procedure, obtaining reliable results.Regarding the mlc qa, the inability to detect systematic displacements make it difficult to confidently use the detector.

Journal: Journal of applied clinical medical physics (2023)
Publication types: Journal Article
Tenosynovial Giant Cell Tumor in the Hand: Experience with 173 Cases.

Tenosynovial giant cell tumor (tsgct) is the second most common benign tumor of the hand.Even though it is a benign lesion there is still a high incidence of local recurrence (range, 7%-44%) according to data in published papers.In this study, the clinical and epidemiological features of 173 patients who underwent excision of localized tsgct, the recurrence rates and possible reasons for recurrence were examined in the light of current literature.methods:medical records of 173 patients with tsgct were reviewed.Data on demographic characteristics as well as clinical and intraoperative findings were collected.Patients were asked about the recurrence of the tsgct and the quick dash scoring was applied at the final clinical evaluation after mean follow-up of 81 months.results:females were predominantly involved (73%).Patients aged mean 44 years at the time of surgery.There were 93 tumors in flexor zones and 80 tumors in extensor zones of the hand.Of the tumors with flexor zone localization, zone ii was most predominantly involved with 46 tumors, and 18 of these were on the index finger.The extensor zones iii and iv were mostly involved with 9 tumors each on the middle and ring fingers.A total of 12 recurrences (6.9 %) were determined over the mean follow-up period of 81 months.conclusions:the characteristics of our patients identified were similar to the previous studies.Surgical excision provides good outcomes in the treatment of tsgct especially when clear margins are obtained.

Journal: The journal of hand surgery Asian-Pacific volume (2020)
Publication types: Journal Article
Boosting Nanomedicine Efficacy with Hyperbaric Oxygen Therapy.

Nanomedicine has been a hot topic in the field of tumor therapy in the past few decades.Because of the enhanced permeability and retention effect (epr effect), nanomedicine can passively yet selectively accumulate at tumor tissues.As a result, it can improve drug concentration in tumor tissues and reduce drug distribution in normal tissues, thereby contributing to enhanced antitumor effect and reduced adverse effects.However, the therapeutic efficacy of anticancer nanomedicine is not satisfactory in clinical settings.Therefore, how to improve the clinical therapeutic effect of nanomedicine has become an urgent problem.The grand challenges of nanomedicine lie in how to overcome various pathophysiological barriers and simultaneously kill cancer cells effectively in hypoxic tumor microenvironment (tme).To this end, the development of novel stimuli-responsive nanomedicine has become a new research hotspot.While a great deal of progress has been made in this direction and preclinical results report many different kinds of promising multifunctional smart nanomedicine, the design of these intelligent nanomedicines is often too complicated, the requirements for the preparation processes are strict, the cost is high, and the clinical translation is difficult.Thus, it is more practical to find solutions to promote the therapeutic efficacy of commercialized nanomedicines, for example, doxil®, oncaspar®, dauno xome®, abraxane®, to name a few.Increasing attention has been paid to the combination of modern advanced medical technology and nanomedicine for the treatment of various malignancies.Recently, we found that hyperbaric oxygen (hbo) therapy could enhance doxil®antitumor efficacy.Inspired by this study, we further carried out researches on the combination of hbo therapy with other nanomedicines for various cancer therapies, and revealed that hbo therapy could significantly boost antitumor efficacy of nanomedicine-mediated photodynamic therapy and photothermal therapy in different kinds of tumors, including hepatocellular carcinoma, breast cancer, and gliomas.Our results implicate that hbo therapy might be a universal strategy to boost therapeutic efficacy of nanomedicine against hypoxic solid malignancies.

Journal: Advances in experimental medicine and biology (2021)
Publication types: Journal Article
Brain Tumor Rehabilitation: Symptoms, Complications, and Treatment Strategy.

Brain tumors are receiving increasing attention in cancer rehabilitation due to their high rate of neurological deterioration.Motor dysfunction, cognitive deterioration, and emotional problems are commonly present in patients with brain tumors.Other medical complications, such as seizures, headache, and dysphagia are also common.An individualized multidisciplinary rehabilitation intervention is necessary to treat functional impairment due to the tumor itself and/or treatment-related dysfunction.Herein, we discuss rehabilitation treatment strategies in relation to the neurological and functional complications that commonly occur in patients with brain tumors.

Journal: Brain & NeuroRehabilitation (2022)
Publication types: Journal Article;Review
Genome-wide identification and characterization of terpene synthase genes in Gossypium hirsutum.

Terpenoids are widely distributed in plants and play important roles in the regulation of plant growth and development and in the interactions between plants and both the environment and other organisms.However, terpene synthase (tps) genes have not been systematically investigated in the tetraploid gossypium hirsutum.In this study, whole genome identification and characterization of the tps family from g.Hirsutum were carried out.Eighty-five tps genes, including 47 previously unidentified genes, were identified in the g.Hirsutum genome and classified into 5 subfamilies according to protein sequence similarities, as follows: 43 gh tps-a, 29 gh tps-b, 4 gh tps-c, 7 gh tps-e/f, and 2 gh tps-g members.These 85 tps genes were mapped onto 19 chromosomes of the g.Hirsutum genome.Segmental duplications and tandem duplications contributed greatly to the expansion of tps genes in g.Hirsutum and were followed by intense purifying selection during evolution.Indentification of cis-acting regulatory elements suggest that the expression of tps genes is regulated by a variety of hormones.Rna sequencing (rna-seq) expression profile analysis revealed that the tps genes had distinct spatiotemporal expression patterns, and several genes were highly and preferentially expressed in the leaves of cotton with gossypol glands (glanded cotton) versus a glandless strain.Virus-induced gene silencing (vigs) of three tps genes yielded plants characterized by fewer, smaller, and lighter gossypol glands, which indicated that these three genes were responsible for gland activity.Taken together, our results provide a solid basis for further elucidation of the biological functions of tps genes in relation to gland activity and gossypol biosynthesis to develop cotton cultivars with low cottonseed gossypol contents.

Journal: Gene (2022)
Publication types: Journal Article
Three different paths to introduce the smallpox vaccine in early 19th century United States.

The ancient technique of variolation (inoculation of the smallpox) which was introduced in the united states in 1721 was replaced by vaccination (inoculation of the cowpox) soon after the procedure was published by edward jenner in 1798.Benjamin waterhouse is recognized as the introducer of smallpox vaccination in the united states having conducted the first vaccination in boston on 8 july 1800, although other american physicians also played an important role in extending vaccination in the east coast of the united states.A different route of introduction brought the smallpox vaccine from mexico to new mexico (march 1805) and texas (april 1806) which at that time where part of the viceroyalty of new spain.The vaccine was brought to california in 1817 by russian merchants who obtained it in peru, where the vaccine had arrived in 1806 with the spanish philanthropic expedition of the vaccine.It took almost 150 years of vaccination efforts before the last natural outbreak of smallpox occurred in the united states in 1949.

Journal: Vaccine (2020)
Publication types: Historical Article;Journal Article;Review
The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism.

Sphingosine 1-phosphate (s1p) is a signaling lipid that has broad roles, working either intracellularly through various protein targets, or extracellularly via a family of five g-protein coupled receptors.agents that selectively and specifically target each of the s1p receptors have been sought as both biological tools and potential therapeutics.Jte-013, a small molecule antagonist of s1p receptors 2 and 4 (s1p2and s1p4) has been widely used in defining the roles of these receptors in various biological processes.Indeed, our previous studies showed that jte-013 had anti-acute myeloid leukaemia (aml) activity, supporting a role for s1p2in the biology and therapeutic targeting of aml.Here we examined this further and describe lipidomic analysis of aml cells that revealed jte-013 caused alterations in sphingolipid metabolism, increasing cellular ceramides, dihydroceramides, sphingosine and dihydrosphingosine.Further examination of the mechanisms behind these observations showed that jte-013, at concentrations frequently used in the literature to target s1p2/4, inhibits several sphingolipid metabolic enzymes, including dihydroceramide desaturase 1 and both sphingosine kinases.Collectively, these findings demonstrate that jte-013 can have broad off-target effects on sphingolipid metabolism and highlight that caution must be employed in interpreting the use of this reagent in defining the roles of s1p2/4.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Climate-induced tree senescence leads to a transient increase in reproductive success of a large woodpecker species.

Climate change-induced mortality of trees is a concerning phenomenon for global forest ecosystems.The rapid decay and death of long-lived trees can significantly impact forest dynamics, with effects that transmit through ecological networks, becoming more evident in organisms occupying high trophic levels, such as large and specialized woodpecker species.However, understanding how populations of high trophic level species respond to climate change is still a challenge.In this study it was analyzed 32-year data of social groups of the magellanic woodpecker (campephilus magellanicus) in north patagonia, a region facing increasingly frequent droughts and increased temperatures.A positive trend in the size of woodpecker social groups as a response to climate-induced tree senescence was tested.A causal structural equation model examining climate- tree senescence- woodpecker relationships was used.Increasing nonlinear trends and positive interannual growth rates (>10%) for tree senescence and group size were found.Lowland forest sites had higher levels of tree senescence and more numerous social groups.The causal model supported the positive effect of mean temperature on tree senescence and the positive association of woodpeckers with tree senescence.These results provide evidence of a climate-induced increase in tree senescence that causes an increase in the size of woodpecker social groups.It is suggested that accelerated decay and mortality of trees in the northern patagonian forests will decrease the stocks of deadwood in the long term, threatening the persistence of this large woodpecker species.

Journal: The Science of the total environment (2022)
Publication types: Journal Article