syedzayyan/paper_mill_benchmark huggingface dataset:
A yeast two-hybrid screening identifies novel Atg8a interactors inDrosophila.

Macroautophagy/autophagy-related protein atg8/lc3 is important for autophagosome biogenesis and required for selective degradation of various substrates.In our recent study, we performed a yeast two-hybrid screening to identify proteins that interact with atg8a, the drosophilahomolog of atg8/lc3.The screening identified several atg8a-interacting proteins.These proteins include: i) proteins which have already been experimentally verified to bind atg8a, such as atg1, dor, ref(2)p and key (kenny); ii) proteins for which their mammalian homologs interact with atg8-family members, like ank2, atg4, and nedd4; and iii) several novel atg8a-interacting proteins, such as trc/stk38 and tak1.We showed that tak1, as well as its co-activator, tab2, both interact with atg8a and are substrates for selective autophagic clearance.We also determined that sh3px1 interacts with tab2 and is necessary for the effective regulation of the immune-deficiency (imd) pathway.Our findings suggest a mechanism for the regulatory interactions between tak1-tab2-sh3px1 and atg8a, which contribute to the fine-tuning of the imd pathway.

Journal: Autophagy (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A case of immune complex mediated tubulointerstitial disease and nephrotic syndrome: anti LRP-2 Nephropathy with diffuse podocyte effacement.

Anti-ldl receptor-related protein 2 (anti-lrp2) nephropathy is a rare form of kidney disease that affects the older patients and is characterized with acute kidney injury (aki) and progressive renal tubular injury associated with ig g immune complex deposits along the basement membrane of proximal tubules, and circulating autoantibodies to the proximal tubule brush border protein lrp2 (megalin).We present the case of a 79-year-old man who was hospitalized for worsening malaise, abdominal distention and bilateral lower extremity edema, diagnosed with aki and had nephrotic range proteinuria.Percutaneous kidney biopsy revealed tubulointerstitial nephritis with ig g immune complex deposits along the basement membrane of proximal tubules and brush borders.Immunofluorescence staining for lrp2 (megalin) showed similar granular tubular basement membrane deposits along the proximal tubules and proximal tubule brush borders.Electron microscopy revealed global podocyte foot process effacement.The patient was started on oral prednisolone 1 mg/kg and rituximab at a dose of 375 mg/m2once weekly for 4 weeks with gradual tapering of prednisone.This case with aki and nephrotic syndrome highlights the significant morphologic overlap with minimal change disease and anti-lrp2 nephropathy, which is associated with autoantibodies to the tubular brush border protein lrp2/megalin.

Journal: Journal of nephrology (2021)
Publication types: Case Reports;Journal Article
Implementation and Outcomes of a Movement Disorder Society-Sponsored Peer Reviewing Education and Mentoring Program.

Effective dissemination of scientific results depends on competent peer reviewers.Participating as a reviewer is important for academic advancement, although no formal training in peer review has existed in the movement disorders field.Objectives to report the design, implementation, and outcomes of a peer reviewing education and mentoring program.Methods we enrolled 10 participants in a 1-year mentored program with didactic training followed by two peer reviews with feedback from a senior mentor.Outcomes measures were an objective skills assessment and subjective questionnaire.Results participants were diverse in gender, age, and background.All participants were deemed competent reviewers by their mentors upon completion.Objective skills improved after didactic training and self-assessment increased significantly after program completion (19.5 [12-25] to 29 [25-30], p < 0.001).Conclusions this dedicated program helped participants gain competence and confidence in the peer review process.We plan to continue the program while improving educational methods and assessments.© 2022 international parkinson and movement disorder society.

Journal: Movement disorders : official journal of the Movement Disorder Society (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Dynamic and molecular association in premicellar aqueous solutions of dicarboxylate amino acid-based surfactant as studied by1H NMR.

We examined a series of amino acid-based surfactants with two carboxylic groups separated by a spacer of one, two, or three carbon atoms with sodium and calcium counterions in the premicellar concentration region near the cmc.1h nuclear magnetic resonance (nmr) spectroscopy and nmr diffusometry techniques were used to study the local environment, association, and translational dynamics of the surfactant's molecules.We measured the self-diffusion coefficients of the micelles, calculated the effective hydrodynamic radii, and determined the temperature region in which the premicelles exist.With an increase in temperature from 295 to 335 k, the premicellar state of the surfactant is replaced by the monomeric state.

Journal: Magnetic resonance in chemistry : MRC (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Recovery and Utilization of Palm Oil Mill Effluent Source as Value-Added Food Products.

The environmental impacts of palm oil mill effluent (pome) have been a concern due to the water pollution and greenhouse gases emissions.Thus, this study was conducted to recover the value-added products from pome source before being discharged.The samples, before (x) and after (y) the pre-recovery system in the clarification tank were sampled and analysed and proximate analysis indicated that both samples are energy rich source of food due to high contents of fats and carbohydrates.Gcms analysis showed that the oil extracts contain predominantly palmitic, oleic, linoleic and stearic acids.Regiospecific analysis of oil extracts by quantitative13c-nmr spectroscopy demonstrated that both oil extracts contain similar degree of saturation of fatty acids at sn-2 and sn-1,3 positions.The samples are rich in various phytonutrients, pro-vitamin a, vitamin e, squalene and phytosterols, thus contributing to exceptionally high total flavonoid contents and moderate antioxidant activities.Overall, samples x and y are good alternative food sources, besides reducing the environmental impact of pome.

Journal: Journal of oleo science (2017)
Publication types: Journal Article
Web of Science's Citation Median Metrics Overcome the Major Constraints of the Journal Impact Factor.

There are many metrics to evaluate the performance and status of journals.Among these, the journal impact factor (jif) has become the dominant metric.The influence of jif is illustrated by its widespread use to evaluate academic status, compensation, and funding decisions.However, as noted by clarivate analytics, the parent company of the web of science (wo s), the jif should not be used without careful attention to the many phenomena that influence citation rates.To facilitate transparency, clarivate analytics provides all data used to determine the jif.In addition, wo s provides other metrics for journal evaluation, including the article citation median and the review citation median.These metrics are represented as medians to minimize the confounding influence of a small number of highly cited articles that may occur when data are represented as means.Another feature of these wo s metrics is that data are separated according to different publication types of article (original research and review).To systematically compare these selected metrics, we used the data provided on the wo s web site to analyze 25 top ranked cardiovascular journals in the same mode as represented in the wo s citation distribution window.The results indicate that the article citation median and review citation median overcome several concerns that have been raised about the jif and seem to provide enhanced objectivity as an indicator of journal impact in publishing original research and reviews.Therefore, we advocate that these additional wo s metrics might be preferentially considered as indicators of journal performance.

Journal: Arteriosclerosis, thrombosis, and vascular biology (2022)
Publication types: Journal Article
Global Research and Scientific Publications on Dexmedetomidine Use in Adults for Anesthesia Care between 2001 and 2021: A Bibliometric Analysis.

An increasing number of studies on dexmedetomidine use in adults have been published, but the effectiveness of dexmedetomidine remains contentious.Objective this study aimed to describe the changing trends and structural relationships of scientific achievements regarding dexmedetomidine over the past 2 decades and provide researchers with information to help them explore better research opportunities.Methods quantitative data of publications were retrieved from the scopus database.Analyses of co-occurrence and collaboration among authors, countries, and key words were conducted using vosviewer 1.6.17 software.Weighted occurrence and average publications per year were calculated.Results the 1868 publications retrieved showed an increasing trend of annual publications on dexmedetomidine use in adults between 2001 and 2021.China accounted for the largest contribution to publications in the world (n = 577 [30.89%]).Four key word clusters indicating research hotspots were identified using vosviewer.The number of articles published in the top 10% of journals in the united states was the highest among all publications from the country (97 out of 201 [48.26%]).Journals from the united kingdom obtained the highest cite score (16.56).journal of anaesthesiology clinical pharmacologypublished the highest number of articles on this topic (n = 56).Wang authored the highest number of published articles (n = 42).Recent publications focused on the theme of cytokines and immunomodulation.sufentanilattracted particular interest as a drug-related key word.Moreover, meta-analysis is becoming an increasingly popular research method in this field.Conclusions the increasing number of publications on dexmedetomidine use reflects growing interest in this topic.Future research should focus on meta-analyses to identify the most effective therapeutic methods.The immunomodulatory effect of dexmedetomidine on health and disease is of particular interest.

Journal: Current therapeutic research, clinical and experimental (2022)
Publication types: Journal Article
Naturalistic evaluation of preschoolers' spontaneous interactions: The Autism Peer Interaction Observation Scale.

Peer interaction can be challenging in autism spectrum disorder, but naturalistic peer-observation scales for preschoolers are limited.This study examined the newly developed autism peer interaction observation scale, with 17 subcategories, which evaluate naturalistic peer interaction processes in preschoolers with autism spectrum disorder and typical development.We tested the autism peer interaction observation scale to (a) characterize peer interactions of preschoolers with autism spectrum disorder who were cognitively able versus typical age-mates, (b) explore each group's hierarchical pattern of peer interaction behaviors, and (c) identify autism peer interaction observation scale's links with standard reports for assessing social-communication functioning (vineland behavior scales, 2nd ed.), social impairment (social responsiveness scale, 2nd ed.), autism severity (autism diagnostic observation schedule, 2nd ed.), and intelligence quotient (mullen) in the cognitively able preschoolers with autism spectrum disorder group.Participants comprised 85 preschoolers (50 cognitively able preschoolers with autism spectrum disorder, intelligence quotient > 75; 35 typical).Groups were matched according to age, intelligence quotient, and maternal education.Significant group differences emerged on all autism peer interaction observation scale categories, with the typical group showing better social-communication functioning as compared to the cognitively able preschoolers with autism spectrum disorder group.Also, in cognitively able preschoolers with autism spectrum disorder that observed as demonstrating more typical peer relations on the autism peer interaction observation scale showed better adaptive and socialization skills on the vineland (vineland behavior scales, 2nd ed.) and fewer social atypicalities on the social responsiveness scale, 2nd ed.Higher intelligence quotient scores were linked with better observed social-communication functioning (on autism peer interaction observation scale).Few autism peer interaction observation scale social-communicative categories significantly correlated with the autism diagnostic observation schedule, 2nd ed.Findings highlight the autism peer interaction observation scale as differentiating the two preschooler groups and providing additional knowledge about socially communicative peer interaction in natural settings.This new tool can help personalize social-communication programs and evaluations of early intervention outcomes, thereby leading to a fuller picture of these young children's functioning.

Journal: Autism : the international journal of research and practice (2021)
Publication types: Journal Article
Spatial-temporal distribution of Dalbulus maidis (Hemiptera: Cicadellidae) and factors affecting its abundance in Brazil corn.

Since the last decade, dalbulus maidis has become the primary pest in cornfields, particularly due to its ability to transmit plant pathogens.Dalbulus maidis is the main vector of the corn stunt spiroplasma and maize bushy stunt phytoplasma.However, there is little information available on this pest.Understanding its spatial dynamics may allow us to determine how its infestations begin and to identify its colonization patterns, dispersal, and the role of landscape structure on d.Maidis dynamics.Thus, this study aimed to investigate within-field spatial distribution and the factors associated with d.Maidis abundance in five commercial fields.Results in all fields, higher infestations occurred at the boundaries of the central pivot, showing a clear edge-biased distribution.Ranges varied from 100.4 to 611.8 m, and our models' overall fit indicated strong to moderate spatial dependency.Additionally, correlation analyses indicated a positive effect of air temperature on the population of d.Maidis.Conversely, rainfall negatively affected d.Maidis.Conclusion this study provides essential guidance for improving d.Maidis integrated pest management at regional and local scales.Based on its high dispersal ability, our study suggests the need for a legislative or regulatory method of control for d.Maidis, especially in regions where corn has more than one growing season.© 2022 society of chemical industry.

Journal: Pest management science (2022)
Publication types: Journal Article
Effects of thermal slip and chemical reaction on free convective nanofluid from a horizontal plate embedded in a porous media.

We consider a two-dimensional, uniform, incompressible and free convection flow of a nano-fluid along a plane.The plate is located facing upward about the porous medium.Throughout the investigation, thermal slip, chemical reaction, heat emission/absorption is considered.In the modeling of nano-fluid we have considered the dynamic effect along with the brownian and thermophoresis.In obtaining the governing equations, including the boundary conditions, an appropriate scaling is applied.The governing momentum equations, including thermal energy and nanoparticles equations are translated into a group of nonlinear odes by using lie symmetry group transformation.The transformed equations are then solved numerically using the runge-kutta-fehlberg fourth-fifth order.The numerical results of velocity, temperature, and nanoparticle volume fraction profiles for varied physical parameters will be discussed and analyzed at the end.The discussion also includes the local nusselt and the local sherwood numbers against several of the systems' physical parameters.It is found that the velocity and temperature decrease with thermal slip and heat absorption whilst it increases by increasing heat generation and chemical reaction order.Our present results will be compared with similar existing literature results.

Journal: Mathematical biosciences and engineering : MBE (2021)
Publication types: Journal Article
How to Choose the Right Inhaler Using a Patient-Centric Approach?

There are many different inhaler devices and medications on the market for the treatment of asthma and chronic obstructive pulmonary disease, with over 230 drug-delivery system combinations available.However, despite the abundance of effective treatment options, the achieved disease control in clinical practice often remains unsatisfactory.In this context, a key determining factor is the match or mismatch of an inhalation device with the characteristics or needs of an individual patient.Indeed, to date, no ideal device exists that fits all patients, and a personalized approach needs to be considered.Several useful choice-guiding algorithms have been developed in the recent years to improve inhaler-patient matching, but a comprehensive tool that translates the multifactorial complexity of inhalation therapy into a user-friendly algorithm is still lacking.To address this, a multidisciplinary expert panel has developed an evidence-based practical treatment tool that allows a straightforward way of choosing the right inhaler for each patient.

Journal: Advances in therapy (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
LncRNA 148400 Promotes the Apoptosis of Renal Tubular Epithelial Cells in Ischemic AKI by Targeting the miR-10b-3p/GRK4 Axis.

Although recent studies have reported that long non-coding rna (lnc rna) is involved in the development of ischemic acute kidney injury (aki), the exact function and regulatory mechanism of lnc rnas in ischemic aki remain largely unknown.Herein, we found that ischemic injury promoted the expression of lnc rna 148400 in mouse proximal tubule-derived cell line (bumpt) and c57bl/6j mice.Furthermore, the lnc rna148400 mediates ischemic injury-induced apoptosis of bumpt cells.Mechanistically, lnc rna 148400 sponged mi r-10b-3p to promote apoptosis via grk4 upregulation.Finally, knockdown of lnc rna 148400 alleviated the i/r-induced deterioration of renal function, renal tubular injury, and cell apoptosis.In addition, cleaved caspase-3 is increased via targeting the mi r-10b-3p/grk4 axis.Collectively, these results showed that lnc rna 148400/mi r-10b-3p/grk4 axis mediated the development of ischemic aki.

Journal: Cells (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain.

Chronic pain is one of the most debilitating human diseases and represents a social and economic burden for our society.Great efforts are being made to understand the molecular and cellular mechanisms underlying the pathophysiology of pain transduction.It is particularly noteworthy that some types of chronic pain, such as migraine, display a remarkable sex dimorphism, being up to three times more prevalent in women than in men.This gender prevalence in migraine appears to be related to sex differences arising from both gonadal and genetic factors.Indeed, the functionality of the somatosensory, immune, and endothelial systems seems modulated by sex hormones, as well as by x-linked genes differentially expressed during development.Here, we review the current data on the modulation of the somatosensory system functionality by gonadal hormones.Although this is still an area that requires intense investigation, there is evidence suggesting a direct regulation of nociceptor activity by sex hormones at the transcriptional, translational, and functional levels.Data are being accumulated on the effect of sex hormones on trp channels such as trpv1 that make pivotal contributions to nociceptor excitability and sensitization in migraine and other chronic pain syndromes.These data suggest that modulation of trp channels' expression and/or activity by gonadal hormones provide novel pathways for drug intervention that may be useful for targeting the sex dimorphism observed in migraine.

Journal: Frontiers in molecular biosciences (2018)
Publication types: Journal Article;Review
Anomalous vasculature in the neck diagnosed by ultrasound.

Anomalous vascular anatomy was detected in the neck of a 52-year-old female with a klippel-feil anomaly.Ultrasound identified three separate arteries in the left carotid sheath without any branching or bifurcations.The vascular waveforms were used to identify the vessels as the internal carotid artery, external carotid artery and vertebral artery.This rare vascular anomaly was confirmed with ct angiography.

Journal: Australasian journal of ultrasound in medicine (2020)
Publication types: Case Reports;Journal Article
Influence of volume of endodontic irrigants used in different irrigation techniques on root canal dentin microhardness.

Introduction overzealous application of endodontic irrigants affects the root canal dentin mechanical properties.The effect of volume of endodontic irrigants on the microhardness of root canal dentin has not been studied.Aim this study assessed the effect of volume of endodontic irrigants used in different final irrigation activation techniques on root canal dentin microhardness (rcdm).Methodology sixty human maxillary central incisors were embedded in acrylic resin in kuttler's endodontic cube to the level of cementoenamel junction.The root samples were randomly divided into 4 experimental groups (n = 15): group-ni-needle irrigation, group-pui-continuous passive ultrasonic irrigation, group-endo vac-apical negative pressure system, group combination- endo vac + pui irrigation.Root canals were instrumented up to size 40 (f4).The resin mounted specimens were sectioned longitudinally into two halves and were reassembled in kuttler's kube to carry out final irrigation activation.A predetermined standardized volume of irrigants was used in each group.The rcdm was measured after root canal instrumentation and after final irrigation using vicker microhardness tester (coronal, middle, and apical third).The reduction in rcdm values (p < 0.0086) were analyzed using kruskal wallis and mann whitney-u tests.Results reduction in rcdm was observed with all the endodontic irrigating techniques tested.Endo vac and combination irrigation techniques showed maximum reduction in rcdm in all thirds of root canal.Conclusion it is concluded that the volume of irrigants and agitation plays a role in reducing rcdm.The overall volume of irrigants to cause maximum reduction was 25 ml, beyond which neither volume nor agitation affects rcdm.

Journal: Indian journal of dental research : official publication of Indian Society for Dental Research (2021)
Publication types: Journal Article