syedzayyan/paper_mill_benchmark huggingface dataset:
Application of offset Dingo instruments in Anterior to Psoas (ATP)/Oblique Lumbar Interbody Fusion (OLIF) procedure: A retrospective study of 80 patients.

Oblique lumbar interbody fusion (olif) is a minimally invasive lumbar fusion procedure that has flourished in recent years.However, complications related to the anterior-to-psoas (atp) approach have been reported.The purpose of this study was to assess the olif technique using offset design "dingo" instruments for the treatment of degenerative lumbar disorders.Methods a retrospective review was performed to identify patients between march 2018 and november 2020 who underwent olif with conventional or modified instruments with a minimum follow-up of 12months.Demographic data were recorded.Operation time, intraoperative blood loss, and length of hospital stay were compared between cohorts.Imaging parameters were measured and compared between cohorts before and after surgery.Clinical outcomes were assessed at each follow-up visit.All complications were reviewed.Results a total of 80 consecutive patients were included.The mean follow-up times for the conventional group and modified group were 14.5months and 16.3months, respectively.The incidence of hip flexion weakness was 27.5% and 7.5% for the conventional cohort and modified cohort, respectively.The modified group was associated with a shorter operation time, shorter length of hospital stay, higher postoperative disk height and better cage position.The symptoms of all patients improved after surgery.At 1-week follow-up, the modified group showed significantly better clinical scores.Conclusions olif with modified instruments and techniques shows promising outcomes in reducing approach-related complications.Additionally, the modified technique is associated with a better cage position, shorter length of hospital stay and less postoperative pain in the early period.

Journal: Neuro-Chirurgie (2022)
Publication types: Journal Article
Pooling finances and relationship satisfaction.

When couples decide to share their lives, they are simultaneously faced with the decision of how (or whether) to pool their finances.Does the way in which couples keep their money affect happiness in their relationship?Drawing on interdependence theory, we demonstrate across six studies (n= 38,534)-including both primary and secondary data-that couples who pool all of their money (compared to couples who keep all or some of their money separate) experience greater relationship satisfaction and are less likely to break up.Though joining bank accounts can benefit all couples, the effect is particularly strong among couples with scarce financial resources (i.e., those with low household income or who report feeling financially distressed).These findings replicate using experimental, cross-sectional, and longitudinal data sets, as well as in both individualistic and collectivist cultures.(psyc info database record (c) 2022 apa, all rights reserved).

Journal: Journal of personality and social psychology (2022)
Publication types: Journal Article
OpenHumidistat: Humidity-controlled experiments for everyone.

Humidity control is a crucial element for a wide variety of experiments.Yet, often naive methods are used that do not yield stable regulation of the humidity, are slow, or are inflexible.Pid-based electropneumatic humidistats solve these problems, but commercial devices are not widespread, typically proprietary and/or prohibitively expensive.Here we describe open humidistat: a free and open-source humidistat for laboratory-scale humidity control that is affordable (€500) and easy to build.The design is based around mixing a humid and dry air flow in varying proportions, using proportional solenoid valves and flow sensors to control flow rates.The mixed flow is led into a measurement chamber, which contains a humidity sensor to provide feedback to the controller, to achieve closed-loop humidity control.

Journal: HardwareX (2022)
Publication types: Journal Article
Complementary Resistive Switching Behavior in Tetraindolyl Derivative-Based Memory Devices.

Complementary resistive switching (crs) devices are more advantageous compared to bipolar resistive switching (brs) devices for memory applications as they can minimize the sneak path problem observed in the case of brs having a crossbar array structure.Here, we report the crs behavior of 1,4-bis(di(1h-indol-3-yl)methyl)benzene (indole1) molecules.Our earlier study revealed that au/indole1/indium tin oxide (ito) devices showed brs under ambient conditions.However, the present investigations revealed that when the device is exposed to 353 k or higher temperatures, dynamic evolution of the au/indole1/ito device from brs to crs occurred with a very good memory window (∼103), data retention (5.1 × 103s), stability (50 days), and device yield (∼ 60%).This work explores the application possibility of indole derivatives toward future ultradense resistive random access memory.

Journal: Langmuir : the ACS journal of surfaces and colloids (2022)
Publication types: Journal Article
Customized head molds reduce motion during resting state fMRI scans.

Head motion causes artifacts in functional magnetic resonance imaging (f mri) scans, a problem especially relevant for task-free resting state paradigms and for developmental, aging, and clinical populations.In a cohort spanning 7-28 years old (mean age 15) we produced customized head-anatomy-specific styrofoam molds for each subject that inserted into an mri head coil.We scanned these subjects under two conditions: using our standard procedure of packing the head coil with foam padding about the head to reduce head motion, and using the customized molds to reduce head motion.In 12 of 13 subjects, the molds reduced head motion throughout the scan and reduced the fraction of a scan with substantial motion (i.e., volumes with motion notably above baseline levels of motion).Motion was reduced in all 6 head position estimates, especially in rotational, left-right, and superior-inferior directions.Motion was reduced throughout the full age range studied, including children, adolescents, and young adults.In terms of the f mri data itself, quality indices improved with the head mold on, scrubbing analyses detected less distance-dependent artifact in scans with the head mold on, and distant-dependent artifact was less evident in both the entire scan and also during only low-motion volumes.Subjects found the molds comfortable.Head molds are thus effective tools for reducing head motion, and motion artifacts, during f mri scans.

Journal: NeuroImage (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
ADP-ribosylation systems in bacteria and viruses.

Adp-ribosylation is an ancient posttranslational modification present in all kingdoms of life.The system likely originated in bacteria where it functions in inter- and intra-species conflict, stress response and pathogenicity.It was repeatedly adopted via lateral transfer by eukaryotes, including humans, where it has a pivotal role in epigenetics, dna-damage repair, apoptosis, and other crucial pathways including the immune response to pathogenic bacteria and viruses.In other words, the same ammunition used by pathogens is adapted by eukaryotes to fight back.While we know quite a lot about the eukaryotic system, expanding rather patchy knowledge on bacterial and viral adp-ribosylation would give us not only a better understanding of the system as a whole but a fighting advantage in this constant arms race.By writing this review we hope to put into focus the available information and give a perspective on how this system works and can be exploited in the search for therapeutic targets in the future.The relevance of the subject is especially highlighted by the current situation of being amid the world pandemic caused by a virus harbouring and dependent on a representative of such a system.

Journal: Computational and structural biotechnology journal (2021)
Publication types: Journal Article;Review
External validation of the CRAX2MACE model in an Italian cohort of patients with suspected coronary artery disease undergoing stress myocardial perfusion imaging.

Prevention and development of diagnostic and therapeutic techniques reduced morbidity and mortality for coronary artery disease (cad).In this context, the cardiovascular risk assessment for major adverse cardiac events (mace) at 2-year (crax2mace) model for prediction of 2-year major adverse cardiac events was developed.We performed an external validation of this model.Methods we included 1003 patients with suspected cad undergoing stress-rest single-photon emission computed tomography myocardial perfusion imaging at our academic center between march 2015 and april 2019.Results considering the occurrence of mace (death from any cause, acute myocardial infarction, or late coronary revascularization), for the crax2mace model the area under the receiver operating characteristic curve was 0.612 and the brier score was 0.061.The hosmer-lemeshow test estimated a non-optimal fit (χ228, p < .001).Considering only hard events (cardiac death, acute myocardial infarction), the external validation of the crax2mace model revealed a brier score of 0.053 and an area under the receiver operating characteristic curve of 0.621.Hosmer-lemeshow test was calculated by deciles and showed a poor fit (χ231, p < .001).Conclusion crax2mace model had a limited value for predicting 2-year major adverse cardiovascular events in an external validation cohort of patients with suspected cad.

Journal: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (2022)
Publication types: Journal Article
68 Ga-FAPI PET/CT Detected Non-PSMA/FDG-Avid Primary Tumor in De Novo Metastatic Prostate Cancer.

68 ga-labeled pet tracer targeting psma is a promising diagnostic approach for staging and restating of prostate cancer (pca), but cases with clinically relevant pca and false-negative psma pet/ct have been reported.In this case, we reported 68 ga-psma, 18 f-fdg, and 68 ga-fapi pet/ct findings in a 65-year-old man with de novo metastatic pca.68 ga-fapi pet/ct detected non-psma/fdg-avid primary pca, consisting with multiparametric mri findings.The subsequent histopathologic examination confirmed a gleason 4 + 5 pca.This case highlighted that 68 ga-fapi pet/ct may be a useful imaging modality for primary pca detection and localization.

Journal: Clinical nuclear medicine (2022)
Publication types: Case Reports;Journal Article
Role of vitamin D in regulating COVID-19 severity-An immunological perspective.

Vitamin d, a key nutrient/prohormone classically associated with skeletal health, is also an important immunomodulator, with pleotropic effects on innate and adaptive immune cells.Outcomes of several chronic, autoimmune, and infectious diseases are linked to vitamin d.Emergent correlations of vitamin d insufficiency with coronavirus-induced disease 2019 (covid-19) severity, alongside empirical and clinical evidence of immunoregulation by vitamin d in other pulmonary diseases, have prompted proposals of vitamin d supplementation to curb the covid-19 public health toll.In this review paper, we engage an immunological lens to discuss potential mechanisms by which vitamin d signals might regulate respiratory disease severity in severe acute respiratory syndrome coronavirus 2 (sars-co v2) infections, vis a vis other pulmonary infections.It is proposed that vitamin d signals temper lung inflammatory cascades during sars-co v2 infection, and insufficiency of vitamin d causes increased inflammatory cytokine storm, thus leading to exacerbated respiratory disease.Additionally, analogous to studies of reduced cancer incidence, the dosage of vitamin d compounds administered to patients near the upper limit of safety may serve to maximize immune health benefits and mitigate inflammation and disease severity in sars-co v2 infections.We further deliberate on the importance of statistically powered clinical correlative and interventional studies, and the need for in-depth basic research into vitamin d-dependent host determinants of respiratory disease severity.

Journal: Journal of leukocyte biology (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Review
Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19.

To systematically explore genetic polymorphisms associated with the clinical outcomes in sars-co v infection in humans.Methods this comprehensive literature search comprised available english papers published in pub med/medline and scopus databases following the prisma-p guidelines and pico/axis criteria.Results twenty-nine polymorphisms located in 21 genes were identified as associated with sars-co v susceptibility/resistance, disease severity, and clinical outcomes predominantly in asian populations.Thus, genes implicated in key pathophysiological processes such as the mechanisms related to the entry of the virus into the cell and the antiviral immune/inflammatory responses were identified.Conclusions although caution must be taken, the results of this systematic review suggest that multiple genetic polymorphisms are associated with sars-co v infection features by affecting virus pathogenesis and host immune response, which could have important applications for the study and understanding of genetics in sars-co v-2/covid-19 and for personalized translational clinical practice depending on the population studied and associated environments.

Journal: International journal of genomics (2020)
Publication types: Journal Article;Review
The nature and biology of basement membranes.

Basement membranes are delicate, nanoscale and pliable sheets of extracellular matrices that often act as linings or partitions in organisms.Previously considered as passive scaffolds segregating polarized cells, such as epithelial or endothelial cells, from the underlying mesenchyme, basement membranes have now reached the center stage of biology.They play a multitude of roles from blood filtration to muscle homeostasis, from storing growth factors and cytokines to controlling angiogenesis and tumor growth, from maintaining skin integrity and neuromuscular structure to affecting adipogenesis and fibrosis.Here, we will address developmental, structural and biochemical aspects of basement membranes and discuss some of the pathogenetic mechanisms causing diseases linked to abnormal basement membranes.

Journal: Matrix biology : journal of the International Society for Matrix Biology (2017)
Publication types: Journal Article;Review;Research Support, U.S. Gov't, Non-P.H.S.;Research Support, N.I.H., Extramural
Cinnamic Acid Ameliorates Nonalcoholic Fatty Liver Disease by Suppressing Hepatic Lipogenesis and Promoting Fatty Acid Oxidation.

Cinnamic acid (ca) has been shown to have many beneficial effects including regulating lipid metabolism and reducing obesity.However, its effect on nonalcoholic fatty liver disease (nafdl) has not been investigated in detail.Thus, we performed this study in order to explore ca's effect on hepatic lipid metabolism and the underlying mechanisms.Method oleic acid (oa) was used to induce lipid accumulation in hep g2 cells.After coincubation with ca, the cells were stained with oil red o and the triglyceride (tg) content was assessed.Key genes in lipogenesis and fatty acid oxidation pathways were tested.Additionally, db/db and wt/wt mice were divided into three groups, with the wt/wt mice representing the normal group and the db/db mice being divided into the nafld and ca groups.After 4 weeks of oral treatment, all mice were sacrificed and the blood lipid profile and liver tissues were assessed.Results ca treatment reduced the lipid accumulation in hep g2 cells and in db/db mouse livers.Acly, acc, fas, scd1, pparγ, and cd36 were significantly downregulated, while cpt1a, pgc1α, and pparαwere significantly upregulated.Conclusion ca's therapeutic effect on nafld may be attributed to its ability to lower hepatic lipid accumulation, which is mediated by suppression of hepatic lipogenesis and fatty acid intake, as well as increased fatty acid oxidation.

Journal: Evidence-based complementary and alternative medicine : eCAM (2021)
Publication types: Journal Article
Clearance of oxytocin and its potentially enzyme resistant analogues in the OXT-receptor compartment of the potassium depolarized rat myometrium.

The time-response behaviour of a group of oxytocin analogues structurally modified on potential sites of oxytocin splitting by tissue inactivation enzymes ("enzyme probes") was investigated ex vivo on the potassium depolarized rat myometrium (at 30°c) and compared with the data obtained in the in vivo experiments.The modified oil-immersion method by kalsner and nickerson was used to record time profiles after cessation of a steady state myometrium contraction triggered by analogues in a high potassium tissue medium.An exchange of the aqueous medium for mineral oil enables to suppress return diffusion of the peptide and to record its irreversible clearance near the corresponding receptor compartment.Response records were analysed by a nonlinear numeric procedure based on combination of steady state and kinetic terms that allows concomitant estimations of affinities from time-response measurements, in the given case for analogues on depolarized myometrium.Potential inactivation-sensitive sites in the oxytocin chain are the ν-terminal peptide bond cys1-tyr2(aminopeptidase splitting), the intramolecular disulphide bridge (reduction and formation of the practically inactive linear peptide) and the c-terminal leu8-gly nh29or the pro7-leu8(postprolin cleaving enzyme) bond, respectively.Clearance rate constants of single peptides in the oxt-receptor compartment were in an interval of 0.025 to 0.28 min-1.The fragment contribution analysis reveals a significant linear additivity of individual structural changes and thus a predictivity of irreversible inactivation rate in the receptor compartment.The most potent inactivation of oxytocin is associated with aminopeptidase splitting; other enzymes may play some though nondecisive role.Less significant differences within the peptide group were found for rate constants for peptide transport between receptor compartment and its external aqueous medium.Besides rate constants, the evaluation of time-response data yields affinity values of the tested peptides and indicates a 25-times desensitation of depolarized compared with a native state.

Journal: Journal of peptide science : an official publication of the European Peptide Society (2022)
Publication types: Journal Article
Performance Assessment of Certain Machine Learning Models for Predicting the Major Depressive Disorder among IT Professionals during Pandemic times.

Major depressive disorder (mdd) is the most common mental disorder in the present day as all individuals' lives, irrespective of being employed or unemployed, is going through the depression phase at least once in their lifetime.In simple terms, it is a mood disturbance that can persist for an individual for more than a few weeks to months.In mdd, in most cases, the individuals do not consult a professional, and even if being consulted, the results are not significant as the individuals find it challenging to identify whether they are depressed or not.Depression, most of the time, cooccurs with anxiety and leads to suicide in few cases, among the employees, who are about to handle the pressure at work and home and mostly unnoticing such problems.This is why this work aims to analyze the it employees who are mostly working with targets.The artificial neural network, which is modeled loosely like the brain, has proved in recent days that it can perform better than most of the classification algorithms.This study has implemented the multilayered neural perceptron and experimented with the backpropagation technique over the data samples collected from it professionals.This study aims to develop a model that can classify depressed individuals from those who are not depressed effectively with the data collected from them manually and through sensors.The results show that deep-mlp with backpropagation outperforms other machine learning-based models for effective classification.

Journal: Computational intelligence and neuroscience (2021)
Publication types: Journal Article
BOVIDS: A deep learning-based software package for pose estimation to evaluate nightly behavior and its application to common elands (Tragelaphus oryx) in zoos.

Only a few studies on the nocturnal behavior of african ungulates exist so far, with mostly small sample sizes.For a comprehensive understanding of nocturnal behavior, the data basis needs to be expanded.Results obtained by observing zoo animals can provide clues for the study of wild animals and furthermore contribute to a better understanding of animal welfare and better husbandry conditions in zoos.The current contribution reduces the lack of data in two ways.First, we present a stand-alone open-source software package based on deep learning techniques, named behavioral observations by videos and images using deep-learning software (bovids).It can be used to identify ungulates in their enclosure and to determine the three behavioral poses "standing," "lying-head up," and "lying-head down" on 11,411 h of video material with an accuracy of 99.4%.Second, bovids is used to conduct a case study on 25 common elands (tragelaphus oryx) out of 5 eaza zoos with a total of 822 nights, yielding the first detailed description of the nightly behavior of common elands.Our results indicate that age and sex are influencing factors on the nocturnal activity budget, the length of behavioral phases as well as the number of phases per behavioral state during the night while the keeping zoo has no significant influence.It is found that males spend more time in rem sleep posture than females while young animals spend more time in this position than adult ones.Finally, the results suggest a rhythm between the standing and lying phases among common elands that opens future research directions.

Journal: Ecology and evolution (2022)
Publication types: Journal Article
SIRT3 attenuates coronary atherosclerosis in diabetic patients by regulating endothelial cell function.

This study aimed to explore the relationship between the sirtuin 3 (sirt3) gene and endothelial cell dysfunction, contributing to the progression of coronary atherosclerosis driven by hyperglycemia.Methods we measured serum sirt3 levels using enzyme-linked immunosorbent assay in 95 patients with type 2 diabetes mellitus (t2dm) who underwent diagnostic coronary angiography.The patients were divided into two groups according to the presence (n = 45) or absence (n = 50) of coronary artery disease (cad).Human aortic endothelial cells (haecs) grown in vitro in a medium with various concentrations of glucose (5.5, 11, 16.5, 22, 27.5, 33, and 38.5 m m) for 24 h were assessed for protein expression of sirt3, peroxisome proliferator-activated receptor alpha (ppar-α), endothelial nitric oxide (no) synthase (e nos), and inducible no synthase (i nos) using western blot analysis.Haecs were subjected to sirt3 overexpression or inhibition through sirt3 adenovirus and si rna transfection.Results serum sirt3 levels were significantly lower in t2dm patients with cad than in those without cad (p = 0.048).The in vitro results showed that hg significantly increased sirt3, ppar-α, and e nos protein expression in a concentration-dependent manner.Moreover, i nos expression was decreased in haecs in response to hg.Reduced ppar-α and e nos levels and increased i nos levels were observed in sirt3 silenced haecs cells.In contrast, sirt3 overexpression significantly improved ppar-α and e nos expression and suppressed i nos expression.Conclusion sirt3 was associated with the progression of atherosclerosis in t2dm patients through upregulation of ppar-α and e nos and downregulation of i nos, which are involved in endothelial dysfunction under hyperglycemic conditions.

Journal: Journal of clinical laboratory analysis (2022)
Publication types: Journal Article