syedzayyan/paper_mill_benchmark huggingface dataset:
State- and water repellency-controllable molecular glass of pillar[5]arenes with fluoroalkyl groups by guest vapors.

Molecular glasses are low-molecular-weight organic compounds that are stable in the amorphous state at room temperature.Herein, we report a state- and water repellency-controllable molecular glass byn-alkane guest vapors.We observed that a macrocyclic host compound pillar[5]arene with the c2f5fluoroalkyl groups changes from the crystalline to the amorphous state (molecular glass) by heating above its melting point and then cooling to room temperature.The pillar[5]arene molecular glass shows reversible transitions between amorphous and crystalline states by uptake and release of then-alkane guest vapors, respectively.Furthermore, then-alkane guest vapor-induced reversible changes in the water contact angle were also observed: water contact angles increased and then reverted back to the original state by the uptake and release of then-alkane guest vapors, respectively, along with the changes in the chemical structure and roughness on the surface of the molecular glass.The water repellency of the molecular glass could be controlled by tuning the uptake ratio of then-alkane guest vapor.

Journal: Chemical science (2022)
Publication types: Journal Article
An Estimation of the Effect of Green Financial Policies and Constraints on Agriculture Investment: Evidences of Sustainable Development Achievement in Northwest China.

Farming' community actively participating as micro-actors in green finance schemes is critical for regional planning and development.On the basis of the extent to which financial progress and sustainable development are coordinated, in a difference-in-differences approach, this article employed 2350 small investigations to estimate the influence of green-finance strategies on peasants' agriculture investment and developed a mediation effect method.It investigates the role of peasant managerial variability in mediating the influence of financial constraints.The results indicate that the introduction of a financial restriction variable reduces the positive impacts of green-finance regulations on peasants' agricultural investment.Moreover, peasants who participate in non-agricultural management exercises are more inclined to take advantage of green financing regulations and are affected via financial restrictions in mediate means.The building of a green-finance sector in remote regions should accomplish unique positioning and rapid growth.

Journal: Frontiers in public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The relationship between childhood abuse and depression among adolescents: The mediating role of school connectedness and psychological resilience.

Adolescent depression is a major public health concern worldwide, and depressive symptoms among adolescents in chinese secondary school increase with grade.Although numerous studies noted that childhood abuse was associated with the development of depression in adolescents, the underlying mediators involved in this pathway remain unclear.Therefore, our study aims to explore whether psychological resilience and school connectedness mediate the association between childhood abuse and depression among chinese adolescents.Methods a cross-sectional survey was carried out among 1607 adolescents at four high schools located in henan province, central china.Structural equation modeling was performed to determine whether psychological resilience and school connectedness mediate the influence of childhood abuse on depression.Results findings revealed that childhood abuse was directly (β = 0.410, p < 0.001) and indirectly (β = 0.141, p < 0.001) related to depression.Specifically, psychological resilience (β = 0.018, p = 0.009), school connectedness (β = 0.087, p < 0.001), and school connectedness together with psychological resilience (β = 0.036, p < 0.001) partially mediated the relationship between childhood abuse and depression.Conclusions the detrimental impact of childhood abuse on adolescents' depression may be reduced by fostering psychological resilience and school connectedness.

Journal: Child abuse & neglect (2022)
Publication types: Journal Article
On the Insignificant Role of the Oxidation Process on Ultrafast High-Spatial-Frequency LIPSS Formation on Tungsten.

The presence of surface oxides on the formation of laser-induced periodic surface structures (lipss) is regularly advocated to favor or even trigger the formation of high-spatial-frequency lipss (hsfl) during ultrafast laser-induced nano-structuring.This paper reports the effect of the laser texturing environment on the resulting surface oxides and its consequence for hsfls formation.Nanoripples are produced on tungsten samples using a ti:sapphire femtosecond laser under atmospheres with varying oxygen contents.Specifically, ambient, 10 mbar pressure of air, nitrogen and argon, and 10-7mbar vacuum pressure are used.In addition, removal of any native oxide layer is achieved using plasma sputtering prior to laser irradiation.The resulting hsfls have a sub-100 nm periodicity and sub 20 nm amplitude.The experiments reveal the negligible role of oxygen during the hsfl formation and clarifies the significant role of ambient pressure in the resulting hsfls period.

Journal: Nanomaterials (Basel, Switzerland) (2021)
Publication types: Journal Article
Connecting flavors in social media: A cross cultural study with beer pairing.

Culture is an important driver of food preferences and largely determines exposure to ingredients combinations.The cultural variety in culinary practices across countries raises the question of how flavor combinations are built and how they transcend individual differences in consumers' preferences.For example, in latin america, despite having similar cultures and language, the diversity in culinary practices leads to different flavor combinations across nations.Therefore, we hypothesize that each country will show different preferences in flavor combinations that could be understood by social media exploration as an innovative approach.One study was conducted exploring social media in four countries (argentina, colombia, peru, and mexico) on a one-year basis, using a list of fifty-seven keywords associated with beer flavors.In a first analysis, the list of mentions from consumers was categorized in frequencies of flavors per country and analyzed using correspondence analysis (ca) and agglomerative hierarchical clustering (ahc).Results showed that the countries could be clustered in three groups.Cluster 1 with mexico and peru, and the rest of the countries in different clusters.The co-occurrence of paired flavors in social media was used to build a similarity matrix that was analyzed using multidimensional scaling (mds) in order to find a pattern of pairing per country.The obtained map was useful to understand the cultural differences in flavor paring per country.Overall, the analysis of flavor pairing through social media was an effective technique to access the structure of flavor pairing for beer in different countries.

Journal: Food research international (Ottawa, Ont.) (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Comparison of Volatile Oil between theLigusticum sineseOliv. andLigusticum jeholenseNakai et Kitag. Based on GC-MS and Chemical Pattern Recognition Analysis.

Ligustici rhizomaet radix (lre r) is the dried rhizomes and roots of ligusticum sinese oliv.(ls) or ligusticum jeholense nakai et kitag.(lj).However, in the market, ls and lj are frequently confused with each other.Since the volatile oils are both the main active components and quality control indicators of lre r, a strategy combining gas chromatography-mass spectrometry (gc-ms) and chemical pattern recognition (cpr) was used to compare the volatile components of lj and ls.Total ion chromatography (tic) revealed that phthalides (i.e., neocnidilide) and phenylpropanoids (i.e., myristicin) could be thought of as the most critical components in the volatile oils of lj and ls, respectively.In addition, the chemical components of the volatile oils in lj and ls were successfully distinguished by hierarchical cluster analysis (hca) and principal component analysis (pca).Moreover, two quality markers, including myristicin and neocnidilide, with a very high discriminative value for the classification of lj and ls, were found by orthogonal partial least squares discriminant analysis (opls-da).The relative contents of myristicin and neocnidilide were 10.86 ± 6.18% and 26.43 ± 19.63% for lj, and 47.43 ± 12.66% and 2.87 ± 2.31% for ls.In conclusion, this research has developed an effective approach to discriminating lj and ls based on volatile oils by combining gc-ms with chemical pattern recognition analysis.

Journal: Molecules (Basel, Switzerland) (2022)
Publication types: Journal Article
Global Health Education and Advocacy: Using BMJ Case Reports to Tackle the Social Determinants of Health.

Since 2013, bmj case reports ( has published over 70 global health case reports from five continents, written by doctors, nurses, students, and allied health professionals.These cases, a burgeoning repository of evidence of how real patients are affected by disease, trauma, violence, sexual assault, conflict, migration, adverse living and working conditions, and poor access to health care, discuss, in addition to clinicopathological findings, the global health problems affecting each patient.The global health problem analysis examines the problems of individual patients, critically appraises the literature, and describes actual and potential solutions for the patient, the local community, and patients affected by similar issues across the world.At present global health literature and learning materials lack a patient focus and real-life context in the analysis of global health problems.Bmj case reports global health case reports are a unique and important tool to learn about and advocate for change in the social, political, cultural, and financial determinants of health as they affect real patients.This growing evidence base brings together clinicians, local service providers, policy makers, and government and non-governmental institutions to effect real change in patients' lives toward improving health.Each global health case report is an excellent resource for learning, and together, these case reports provide essential reading for anyone embarking on a career in global health, and writing their own case report.The online course ( at bmj case reports uses these cases and is free to access.

Journal: Frontiers in public health (2018)
Publication types: Journal Article;Review
Diterpenoids from Zhumeria majdae roots as potential heat shock protein 90 (HSP90) modulators.

Four undescribed and 17 known diterpenoids were isolated from the roots of zhumeria majdae rech.f.& wendelbo.Using 1d and 2d nmr spectroscopy, ecd spectroscopy, and hresims data analysis, the structures of the undescribed compounds were elucidated.The anti-proliferative activity of isolated compounds was evaluated against he la and mcf7 cancer cell lines.The binding affinity of all compounds to hsp90, one of the targets for the modern anticancer therapy, was investigated using surface plasmon resonance.The results demonstrated that lanugon q interacted with the chaperone.To explain its mechanism of action, experimental and computational tests were also conducted.

Journal: Phytochemistry (2021)
Publication types: Journal Article
Adherence to non-pharmacological preventive measures among healthcare workers in a middle-income country during the first year of the COVID-19 pandemic: Hospital and community setting.

This study assessed, using a self-reported questionnaire, the adherence to ppe (mask, gowns, and gloves) at the workplace, as well as to non-pharmacological preventive measures (nppm) (physical distance defined as hardly ever and/or never approaches other people within 1.5 meters, social isolation as leaving home less than once a week, hand hygiene was defined as performing hand hygiene ≥ 6 times per period, and adherence to the use of a mask outside of the workplace was defined as on all outings and hardly ever and/or never removes the mask) outside of the workplace among 1,296 health care workers (hcws), including if nppm adherence was associated with covid-19 in hcws.High adherence to ppe was independently associated with younger age, professional category, work in an area of direct patient assistance; use of public transportation, or adherence to nppm outside of the workplace.

Journal: American journal of infection control (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Imputation of Human Primary Osteoblast Single Cell RNA-Seq Data Identified Three Novel Osteoblastic Subtypes.

Recently, single-cell rna sequencing (sc rna-seq) technology was increasingly used to study transcriptomics at a single-cell resolution, sc rna-seq analysis was complicated by the "dropout", where the data only captures a small fraction of the transcriptome.This phenomenon can lead to the fact that the actual expressed transcript may not be detected.We previously performed osteoblast subtypes classification and dissection on freshly isolated human osteoblasts.Materials and methods here, we used the sc impute method to impute the missing values of dropout genes from a sc rna-seq dataset generated on freshly isolated human osteoblasts.Results based on the imputed gene expression patterns, we discovered three new osteoblast subtypes.Specifically, these newfound osteoblast subtypes are osteoblast progenitors, and two undetermined osteoblasts.Osteoblast progenitors showed significantly high expression of proliferation related genes (fos, jun, junband jund).Analysis of each subtype showed that in addition to bone formation, these undetermined osteoblasts may involve osteoclast and adipocyte differentiation and have the potential function of regulate immune activation.Conclusions our findings provided a new perspective for studying the osteoblast heterogeneity and potential biological functions of these freshly isolated human osteoblasts at the single-cell level, which provides further insight into osteoblasts subtypes under various (pathological) physiological conditions.

Journal: Frontiers in bioscience (Landmark edition) (2022)
Publication types: Journal Article
Real-time mental stress detection using multimodality expressions with a deep learning framework.

Mental stress is becoming increasingly widespread and gradually severe in modern society, threatening people's physical and mental health.To avoid the adverse effects of stress on people, it is imperative to detect stress in time.Many studies have demonstrated the effectiveness of using objective indicators to detect stress.Over the past few years, a growing number of researchers have been trying to use deep learning technology to detect stress.However, these works usually use single-modality for stress detection and rarely combine stress-related information from multimodality.In this paper, a real-time deep learning framework is proposed to fuse ecg, voice, and facial expressions for acute stress detection.The framework extracts the stress-related information of the corresponding input through res net50 and i3d with the temporal attention module (tam), where tam can highlight the distinguishing temporal representation for facial expressions about stress.The matrix eigenvector-based approach is then used to fuse the multimodality information about stress.To validate the effectiveness of the framework, a well-established psychological experiment, the montreal imaging stress task (mist), was applied in this work.We collected multimodality data from 20 participants during mist.The results demonstrate that the framework can combine stress-related information from multimodality to achieve 85.1% accuracy in distinguishing acute stress.It can serve as a tool for computer-aided stress detection.

Journal: Frontiers in neuroscience (2022)
Publication types: Journal Article
Patients on psychotropic medications and herbal supplement combinations: clinical considerations.

Populations using herbs and herbal preparations are widespread and growing.As many herbal ingredients exert actions on psychotropic drug targets, psychiatrists should be well informed and aware of potential drug-drug interactions in clinical practice.Reliable and clinically useful information in this area, however, is fragmented, if not deficient.This paper reviewed the clinical aspects of herb-drug interactions, focusing in particular on the monoamine oxidase enzyme and p450 cytochrome enzyme-inhibitory properties of herbs and their potential interference with psychotropic drug actions and clinical judgement.

Journal: International clinical psychopharmacology (2017)
Publication types: Journal Article;Review
Reproducible Research Practices in the Plastic Surgery Literature.

Reproducible research-defined as the ability to replicate a study with its published materials and procedures-is integral to ensuring the validity of published studies and promoting scientific advancement.The primary aim of this study was to quantitatively evaluate the reproducibility and transparency of research in the plastic surgery literature.Methods a cross-sectional study was performed.Articles published in 12 plastic surgery journals over a 5-year period were randomly selected.Reproducibility-related and transparency-related variables were blindly and independently collected by two reviewers using previously published methods.Descriptive statistics and univariate analysis were performed for outcomes of interest.Results the initial search yielded 18,461 publications, from which 400 were randomly selected.A total of 397 publications met inclusion criteria, of which 203 were empirical studies eligible for analysis of reproducibility-related and transparency-related variables.Among the empirical studies, most did not have a data availability statement (97.0 percent; 95 percent ci, 93.7 to 98.9).Only seven (3.4 percent; 95 percent ci, 1.4 to 7.0) were linked to an accessible protocol, four (2.0 percent; 95 percent ci, 0.5 to 5.0) were preregistered, and no studies provided analysis scripts or claimed to replicate another study.Of the 202 studies evaluated for material availability, only 17 (8.4 percent; 95 percent ci, 5.0 to 13.1) had a material availability statement.Conclusions there is an evident lack of reproducible research practices in plastic surgery literature.The majority of plastic surgery publications do not provide information and raw materials necessary to reproduce empirical studies.Increasing awareness at the individual and institutional levels can improve research quality and transparency.

Journal: Plastic and reconstructive surgery (2022)
Publication types: Journal Article
Development of a simple, rapid, and sensitive diagnostic assay for enterotoxigenic E. coli and Shigella spp applicable to endemic countries.

Enterotoxigenic e.Coli (etec) and shigella spp (shigella) are complex pathogens.The diagnostic assays currently used to detect these pathogens are elaborate or complicated, which make them difficult to apply in resource poor settings where these diseases are endemic.The culture methods used to detect shigella are not sensitive, and the methods used to detect etec are only available in a few research labs.To address this gap, we developed a rapid and simple diagnostic assay-"rapid lamp based diagnostic test (rldt)." the six minutes sample preparation method directly from the fecal samples with lyophilized reaction strips and using established loop-mediated isothermal amplification (lamp) platform, etec [heat labile toxin (lt) and heat stable toxins (sth, and stp) genes] and shigella (ipa h gene) detection was made simple, rapid (<50 minutes), and inexpensive.This assay is cold chain and electricity free.Moreover, rldt requires minimal equipment.To avoid any end user's bias, a battery-operated, handheld reader was used to read the rldt results.The results can be read as positive/negative or as real time amplification depending on the end user's need.The performance specifications of the rldt assay, including analytical sensitivity and specificity, were evaluated using fecal samples spiked with etec and shigella strains.The limit of detection was ~105 cfu/gm of stool for lt, sth, and stp and ~104 cfu/gm of stool for the ipa h gene, which corresponds to about 23 cfu and 1 cfu respectively for etec and shigella per 25u l reaction within 40 minutes.The rldt assay from stool collection to result is simple, and rapid and at the same time sufficiently sensitive.Rldt has the potential to be applied in resource poor endemic settings for the rapid diagnosis of etec and shigella.

Journal: PLoS neglected tropical diseases (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Parents' refusal to vitamin-K supplementation among neonates and its association with vaccine refusal: A systematic review and meta-analysis.

This systematic review and meta-analysis aims to estimate the prevalence of neonatal vitamin k prophylaxis refusal among parents and its possible association with subsequent vaccine hesitancy or refusal.Methods the databases searched included pub med, cochrane library, embase via ovid, cinahl plus and medline via ebscohost, pro quest and psyc info from inception to 31 august 2017.Keywords, such as "vitamin k", "refusal", "decline", "hesitancy", and "vaccination" were used to identify potential studies.Analysis of proportions was conducted, while odd ratios and relative risks were estimated using the random effect model.Results of the 2216 studies identified, 8(0.36%) were subjected to qualitative analysis; 4(50%) retrospective cohort studies and 4(50%) cross-sectional studies.Overall, 6(75%) studies were of good quality, while 2(25%) were ranked as of fair quality.Of the 273,714 parents, 3,136(1.14%) refused to opt for the vitamin k prophylaxis.Meta-analysis concluded that refusal to vitamin k prophylaxis was significant among the included studies ((p<0.184).Conclusions the overall risk of refusal to essential vaccination among vitamin k prophylaxis refusal group was 6.45 times compared to the group that accepted vitamin k prophylaxis.

Journal: JPMA. The Journal of the Pakistan Medical Association (2022)
Publication types: Meta-Analysis;Systematic Review;Journal Article
Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans.

Many unknowns exist about human immune responses to the severe acute respiratory syndrome coronavirus 2 (sars-co v-2) virus.Sars-co v-2-reactive cd4+t cells have been reported in unexposed individuals, suggesting preexisting cross-reactive t cell memory in 20 to 50% of people.However, the source of those t cells has been speculative.Using human blood samples derived before the sars-co v-2 virus was discovered in 2019, we mapped 142 t cell epitopes across the sars-co v-2 genome to facilitate precise interrogation of the sars-co v-2-specific cd4+t cell repertoire.We demonstrate a range of preexisting memory cd4+t cells that are cross-reactive with comparable affinity to sars-co v-2 and the common cold coronaviruses human coronavirus (hco v)-oc43, hco v-229e, hco v-nl63, and hco v-hku1.Thus, variegated t cell memory to coronaviruses that cause the common cold may underlie at least some of the extensive heterogeneity observed in coronavirus disease 2019 (covid-19) disease.

Journal: Science (New York, N.Y.) (2020)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't