syedzayyan/paper_mill_benchmark huggingface dataset:
Application of Artificial Intelligence in Cardiovascular Imaging

During the last two decades, as computer technology has matured and business scenarios have diversified, the scale of application of computer systems in various industries has continued to expand, resulting in a huge increase in industry data.As for the medical industry, huge unstructured data has been accumulated, so exploring how to use medical image data more effectively to efficiently complete diagnosis has an important practical impact.For a long time, china has been striving to promote the process of medical informatization, and the combination of big data and artificial intelligence and other advanced technologies in the medical field has become a hot industry and a new development trend.This paper focuses on cardiovascular diseases and uses relevant deep learning methods to realize automatic analysis and diagnosis of medical images and verify the feasibility of ai-assisted medical treatment.We have tried to achieve a complete diagnosis of cardiovascular medical imaging and localize the vulnerable lesion area.(1) we tested the classical object based on a convolutional neural network and experiment, explored the region segmentation algorithm, and showed its application scenarios in the field of medical imaging.(2) according to the data and task characteristics, we built a network model containing classification nodes and regression nodes.After the multitask joint drill, the effect of diagnosis and detection was also enhanced.In this paper, a weighted loss function mechanism is used to improve the imbalance of data between classes in medical image analysis, and the effect of the model is enhanced.(3) in the actual medical process, many medical images have the label information of high-level categories but lack the label information of low-level lesions.The proposed system exposes the possibility of lesion localization under weakly supervised conditions by taking cardiovascular imaging data to resolve these issues.Experimental results have verified that the proposed deep learning-enabled model has the capacity to resolve the aforementioned issues with minimum possible changes in the underlined infrastructure.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Application of Apriori Improvement Algorithm in Asthma Case Data Mining

In chinese medicine, asthma cases contain a large amount of empirical data which are obtained from the clinical diagnosis of doctors throughout the year.Data correlation analysis method is among the common mechanisms which are used to mine association between the (1) prescriptions and prescribers (doctors in this case) and (2) symptoms and medications for a particular disease in the hospitals.In this paper, initially, a thorough analysis of expected performance and shortcomings of the apriori algorithm in mining of medical case data is presented.Secondly, we propose an extended version of the traditional apriori algorithm which is primarily based on the fast response of computer to bit-string logic operation.A comparative evaluation of the proposed and existing apriori algorithms is presented particularly in terms of running time, mining of frequent items set and strong association rules.Both experimental and simulation results have proved that the proposed extended apriori algorithm has outperformed existing algorithms when it is applied to asthma medication and combined symptom-medication data for the association analysis.Furthermore, the association relationship between mind asthma case data and medication is effective in the analysis of asthma case data with significant application value which is verified by the experimental data and observations.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Application Effect and Prognosis of High-Quality Nursing in the Whole Process of Nursing in Lung Cancer Surgery

To explore the application effect and prognostic benefits of whole-course high-quality nursing in lung cancer patients after surgery.Methods.Sixty patients with lung cancer who underwent surgical treatment in the department of respiratory medicine from april 2020 to july 2021 were recruited and assigned to receive either conventional nursing (control group) or whole-course high-quality nursing (intervention group) using the random number table method, with 30 cases in each group.Outcome measures included self-rating anxiety scale (sas) scores, self-rating depression scale (sds) scores, nursing compliance, patient satisfaction, complications, and patient prognosis.Results.Patients receiving whole-course high-quality nursing showed significantly lower sas and sds scores versus those given conventional nursing ( p &lt; 0.05 ).Whole-course high-quality nursing resulted in higher patient compliance versus conventional nursing ( p &lt; 0.05 ).Patients in the intervention group were more satisfied with the nursing compared with those in the control group ( p &lt; 0.05 ).Whole-course high-quality nursing resulted in a lower incidence of complications, postoperative recurrence, and mortality versus conventional nursing ( p &lt; 0.05 ).Conclusion.Whole-course high-quality nursing alleviates the negative emotions of patients after lung cancer surgery, enhances patient compliance and satisfaction, and reduces the incidence of postoperative relapse and complications, which demonstrates great potential for clinical promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Antibacterial and Antioxidant Effects of Magnesium Alloy on Titanium Dental Implants

S.In this study, a new type of dental implant by covering the surface of the titanium (ti) implant with zinc-magnesium (zn-mg) alloy was designed, to study the antibacterial and antioxidant effects of mg alloy on titanium (ti) implants in oral implant restoration.Methods.Human gingival fibroblasts (hgfs), s.Sanguinis, and f.Nucleatum bacteria were used to detect the bioactivity and antibacterial properties of mg alloy-coated ti implants.In addition, b6/j mice implanted with different materials were used to further detect their antibacterial and antioxidant properties.Results.The results showed that mg alloy could better promote the adhesion and proliferation and improve the alkaline phosphatase (alp) activity of hgfs, which contributed to better improved stability of implant osseointegration.In addition, mg alloy could better inhibit the proliferation of s.Sanguinis, while no significant difference was found in the proliferation of f.Nucleatum between the two implants.In the mouse model, the peripheral inflammatory reaction and oxidative stress of the mg alloy implant were significantly lower than those of the ti alloy implant.Conclusions.Zn-mg alloy-coated ti implants could better inhibit the growth of gram-positive bacteria in the oral cavity, inhibit oxidative stress, and facilitate the proliferation activity of hgfs and the potential of osteoblast differentiation, thus, better increasing the stability of implant osseointegration.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Therapeutic Effect and Mechanism of Cinnamyl Alcohol on Myocardial Ischemia-Reperfusion Injury

To investigate the effect of ca on autophagy and its molecular mechanism after myocardial ischemia/reperfusion injury (mi/ri).Methods.The mi/ri model was established by the ligation of the left anterior descending coronary artery with ischemia and reperfusion.In vitro cell models were established using hypoxia/reoxygenation.Western blot was used to determine the expression levels of beclin-1, p62, and lc3 ii.The expression levels of il-1β, il-6, tnfα, and apoptosis-related genes bax, cyt-c, and bcl-2 were detected by q rt-pcr.Cell activity was detected by cck-8.Apoptosis was detected by tunel staining.Results.Beclin-1, p62, and lc3 ii protein expression and lc3 ii/lc3 i level were significantly increased after myocardial ischemia-reperfusion injury.Compared with model group, ca downregulated beclin-1, p62, and lc3 ii protein expression and lc3 ii/lc3 i level in the myocardium.The results of cell-level experiments showed that ca inhibited the autophagy response of the cardiomyocytes induced by hypoxia-reperfusion injury.Mechanism studies showed that ca targeted the inhibition of atg12.Knocking down atg12 reduces the production of inflammatory cytokines induced by h/r.The knockdown of atg12 also reduced apoptosis and injury of the myocardial cells.Conclusion.Myocardial ischemia-reperfusion can enhance autophagy response and promote apoptosis.Ca plays a protective role in myocardium by targeting atg12, thereby inhibiting autophagy and improving myocardial cell apoptosis.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
The Role of C-Reactive Protein in the Prognosis of Prostate Cancer: A Meta-Analysis

To investigate the role of c-reactive protein (crp) in the prognosis of prostate cancer (pca).Methods.The studies related to c-reactive protein and prostate cancer were searched by computer, including pub med and web of science.The retrieval time was from the establishment of the database to august 2022.Quadas score was employed to assess the studies’ quality, funnel plot was employed to analyze the bias of the included studies, and rev man and stata statistical software programs were used to draw forest maps to represent the analysis results.Results.In the initial examination, 432 articles were obtained.After removing the duplicate articles, reading the abstract and theme, and then reading the full text, 12 articles finally met the inclusion criteria.The results revealed that serum c-reactive protein (crp) levels were associated with overall survival (os) in patients with pca (or = 1.47 [1.19, 1.82], p &lt; 0.05 ), and patients with high crp levels had an increased risk of developing prostate cancer (hr = 0.26, 95% ci: 0.23, 0.29).However, there was no obvious difference in circulating crp levels between patients with prostate cancer and healthy controls ( p &gt; 0.05 ).Conclusions.Crp levels are associated with pca patients′ os.High crp levels have an elevated incidence of pca, but there was no obvious distinction in circulating crp levels between patients with prostate cancer and healthy controls.Therefore, c-reactive protein has certain reference value for judging the prognosis of prostate cancer.

Journal: Journal of Environmental and Public Health (2023)
Publication types: Meta-Analysis;
The Relationship between VEGF-C, TAM, and Lymph Node Metastasis in Oral Cancer

To investigate the relationship between vascular endothelial growth factor-c (vegf-c) and tumor-associated macrophages in oral cancer (tams) with lymph node metastasis.Method.From january 2018 to january 2022, 155 cases of oral cancer tissues and 165 cases of normal mucosal tissues were collected from oral surgical resection tissues or biopsy specimens in hebei eye hospital.Oral cancer tissues were observed.The control group had normal mucosal tissues.The clinical and immune parameters were observed and the treatment of oral cancer is also briefly discussed.Results.The number of tams and the expression of vegf-c in oral cancer tissues were significantly higher than those in normal tissues ( p &lt; 0.05 ).The lymphatic vessel density, the number of tams, and the expression of vegf-c in the metastatic group were higher than in nonmetastatic group, and the lymphatic vessel density, the number of tams, and the expression of vegf-c in the paracancerous tissues were higher than central tumor tissue in the metastatic group ( p &lt; 0.05 ).Univariate analysis showed that the number of tams was related to the histological stage and the pathological type of oral cancer ( p &gt; 0.05 ).The expression of vegf-c was associated with the histological stage of oral cancer ( p &lt; 0.05 ).Compared with the immune function after different treatments, the contents of cd4+ in both groups was higher than before, and the combined treatment group was increased more than single treatment group ( p &lt; 0.05 ).The contents of cd3+ and cd8+ in the two groups were lower than before, and the combined treatment group was decreased higher than combined treatment group ( p &lt; 0.05 ).Conclusions.The number of tams and the expression of vegf-c in oral cancer tissues are higher than normal tissues.The number of tams and the expression of vegf-c are higher in patients with lymph node metastasis.Tams and vegf-c may play an important role in lymph node metastasis of oral cancer.Integrated traditional chinese and western medicine can improve the immune function of patients with oral cancer and may improve the therapeutic efficacy.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
The Influence of Ixeris sonchifolia Hance Injection Combined with Isosorbide Mononitrate in Patients with Coronary Heart Disease and Diabetes

To evaluate the influence of ixeris sonchifolia hance injection combined with isosorbide mononitrate in patients with coronary heart disease (chd) and diabetes.Methods.60 patients with chd and diabetes mellitus admitted to our hospital between january 2019 and june 2020 were recruited and assigned via the random number table method at a ratio of 1 : 1 to receive either isosorbide mononitrate treatment (control group) or ixeris sonchifolia hance injection plus isosorbide mononitrate treatment (observation group).Outcome measures included left ventricular end diastolic pressure (lvedp), left ventricular end systolic volume (lvesv), left ventricular function (lvef), brain natriuretic peptide (bnp), and the total treatment efficiency.Results.The two groups had similar lvedp, lvesv, and lvef before treatment ( p &gt; 0.05 ).After treatment, the lvedp and lvesv of the two groups declined ( p &lt; 0.05 ), whereas lvef increased ( p &lt; 0.05 ), with lower lvedp and lvesv and higher lvef in the observation group than in the control group ( p &lt; 0.05 ).Before treatment, there were no significant differences in the bnp levels between the two groups ( p &gt; 0.05 ).After treatment, the observation group had a more significant reduction in the bnp levels versus the observation group ( p &lt; 0.05 ).The observation group showed a higher treatment efficacy than the control group ( p &lt; 0.05 ).Conclusion.Ixeris sonchifolia hance plus isosorbide mononitrate may offer a viable alternative in the treatment of patients with chd and diabetes mellitus.Future trials are, however, required prior to clinical promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
The Impact of Standardized Health Education in Patients with Ischemic Stroke on Patient Management Satisfaction and Quality of Clinical Management Services

Ischemic stroke is a common brain disease, which seriously affects the quality of life of patients.The purpose of this study was to evaluate the impact of the application of standardized health education in ischemic stroke patients on patient management satisfaction and clinical management service quality.Methods.220 patients with ischemic stroke were chosen for study target.The research objects were randomly divided into control group ( n = 110 ) and education group ( n = 110 ) by odd even number draw lots.The control group conducted conventional treatment; on the basis of the control group, the education group received standardized health education.The impact of the application of standardized health education in patients with ischemic stroke on patient management satisfaction and clinical management service quality was analyzed.Results.The number of health error items in the two groups decreased significantly after 2 months and 3 months of treatment, contrast to before admission, and the number of health error items in the education group was lower than that in the control group, and the difference was statistically significant.After 3 months of treatment, the daily activity score increased and the neurological function score decreased in the two groups, and the daily activity score in the education group was higher than that in the control group, and the neurological function score was lower than that in the control group; the difference was statistically significant.The satisfaction scores of patients in the education group in different aspects such as staff working attitude, health management, diet management, and environmental management were higher than those in the control group, and the disparity was obvious.Conclusion.The application of standardized health education in patients with ischemic stroke has certain clinical value.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
The Identification and Clinical Value Evaluation of CYCS Related to Asthma through Bioinformatics Analysis and Functional Experiments

Asthma is one of the most common respiratory diseases and one of the largest burdens of health care resources across the world.This study is aimed at using bioinformatics methods to find effective clinical indicators for asthma and conducting experimental validation.Methods.We downloaded gse64913 data and performed differentially expressed gene (deg) screening.Weighted gene coexpression network analysis (wgcna) on degs was applied to identify key module most associated with asthma for protein-protein interaction (ppi) analysis.According to the degree value, ten genes were obtained and subjected to expression analysis and receiver operating characteristic (roc) analysis.Next, key genes were screened for expression analysis and immunological analysis.Finally, cell counting kit-8 (cck-8) and q rt-pcr were also conducted to observe the influence of hub gene on cell proliferation and inflammatory cytokines.Results.From the gse64913 dataset, 711 upregulated and 684 downregulated degs were found.In wgcna, the top 10 genes in the key module were examined by expression analysis in asthma, and cycs was determined as an asthma-related oncogene with a good predictive ability for the prognosis of asthmatic patients.Cycs is significantly associated with immune cells, such as hhla2, ido1, tgfbr1, and ccl18 and promoted the proliferation of asthmatic cells in vitro.Conclusion.Cycs plays an oncogenic role in the pathophysiology of asthma, indicating that this gene may become a novel diagnostic biomarker and promising target of asthma treatment.

Journal: Disease Markers (2023)
Publication types: Research Article;
The Efficacy of Minocycline Hydrochloride Combined with Multiple Antibiotic Paste in Elderly Patients with Chronic Periodontitis and Concomitant Pulp Lesions

To explore the efficacy of minocycline hydrochloride combined with multiple antibiotic pastes in the treatment of chronic periodontitis with concomitant pulp lesions in elderly patients, as well as to analyze the changes in the levels of inflammatory markers.Methods.100 patients suffering from chronic periodontitis with concomitant pulp lesions treated in our hospital from july 2018 to january 2020 were selected as the study subjects, and were randomly assigned to either an experimental group (n = 50) or a control group (n = 50).Patients in the experimental group were treated with minocycline hydrochloride combined with multiple antibiotic pastes, while those in the control group were treated with minocycline hydrochloride alone.The treatment efficacy in the two groups was then assessed using such factors as periodontal probing depth, dental plaque index, gingival index, periodontal attachment level, and the presence or absence of adverse effects.We also measured and compared the levels of inflammatory markers such as crp, tnf-α, il-1β, il-5, il-6, and others in both groups, before treatment, as well as after a week of treatment.Results.There was a statistically significant difference in the treatment efficacy between the two groups ( p &lt; 0.05 ), with a higher treatment efficacy seen in the experimental group as compared to the control group.When compared to the control group, the experimental group had lower depths of periodontal probing, lower dental plaque indices, lower gingival indices, lower periodontal attachment levels, as well a significantly lower incidence of adverse reactions ( p &lt; 0.05 ).Before treatment, the levels of inflammatory markers such as crp, tnf-α, il-1β, il-5, and il-6 were elevated in both groups.After a week of treatment, there were reductions in the levels of inflammatory markers in both groups, but a more significant reduction was seen in the experimental than in the control group ( p &lt; 0.05 ).Conclusion.Minocycline hydrochloride combined with various antibiotic pastes is more effective in the treatment of chronic periodontitis with concomitant pulp lesions in elderly patients than monotherapy with minocycline hydrochloride alone.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
The Effect of TLR9, MyD88, and NF-κB p65 in Systemic Lupus Erythematosus

This study was conducted to characterize the expression level of peripheral blood toll-like receptors 9 (tlr9), nuclear factor kappa-b protein 65 (nf-κb p65), and myeloid differentiation factor88 (my d88) of active systemic lupus erythematosus (sle) and analyse their clinical significance.Methods.The prospective cohort study enrolled 30 active sle patients (sg1 group), 30 stable sle patients (sg2 group), and 20 healthy individuals (rg group) in the first affiliated hospital of hainan medical university between january 2018 and june 2020.All sle patients were treated with methylprednisolone tablets.Quantitative polymerase chain reaction (q pcr) was used to determine the levels of tlr9, my d88, and nf-κb p65 in the peripheral blood mononuclear cell (pbmc).Elisa was adopted for the determination of serum interleukin (il-6) and tumor necrosis factor-α (tnf-α).Results.Patients in sg1 showed the highest m rna levels of tlr9, my d88, and nf-κb p65, followed by sg2, and then rg.Sg1 had the highest serum levels of il-6 and tnf-α, followed by sg2 and rg.The level of tlr9 was positively correlated with the sle disease activity index (sledai) and negatively correlated with complement component 3 (c3) and complement component 4 (c4).My d88 and nf-κb p65 were positively correlated with sledai.Conclusion.Compared with a healthy status, sle induces an increase in tlr9, my d88, nf-κb p65, il-6, and tnf-α levels, and the activation of the tlr9-my d88-nf-κb p65 signal path was associated with the pathogenesis of sle.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;