syedzayyan/paper_mill_benchmark huggingface dataset:
Effects of Self-Made Prescription Compound Rhodiola on the Ultrastructure of Podocytes in Rats with Type 2 Diabetic Nephropathy

We attempt to discuss the function of self-made prescription compound rhodiola rosea on the kidneys of rats with type 2 diabetic nephropathy (dn), through studying the effects of self-made rescription compound rhodiola rosea on the ultrastructure of podocytes in rats with dn.Methods.Dn rat model was established by streptozotocin.The successfully modeled rats were divided into 4 groups, dn group, compound rhodiola low-dose group, medium-dose group, and high-dose group.Compound rhodiola low-dose group, medium-dose group, and high-dose group were administered for 8 weeks, and the dn group and the blank control group were administered with normal saline.The podocyte count, podocyte width, podocyte fusion rate, and average thickness of glomerular basement membrane were compared in each group, and the ultrastructural changes in podocytes were observed by transmission electron microscope.Results.Compared with the normal control group, the number of podocytes in the dn group remarkably reduced, but the width level of podocyte, the fusion rate of podocyte, and the average thickness of basilar membrane remarkably increased ( p &lt; 0.05 ).Compared with the dn group, the number of podocytes in the high-, medium-, and low-dose groups increased remarkably, but the width level of podocyte, the fusion rate of podocyte, and the average thickness of basilar membrane decreased remarkably ( p &lt; 0.05 ).Compared with the low-dose group, the number of podocytes in the high-dose group and the medium-dose group increased remarkably, but the width of podocyte, the fusion rate of podocyte, as well as the average thickness of basilar membrane remarkably reduced ( p &lt; 0.05 ).Various indicators of high- and medium-dose groups had no statistical difference ( p &gt; 0.05 ).Conclusions.Self-made prescription compound rhodiola rosea can promote the recovery of podocyte in dn rat and protect their kidney.

Journal: Emergency Medicine International (2022)
Publication types: Research Article;
Effectiveness and Safety Analysis of Plasma Beam in the Treatment of Facial Depressed Scars

The study aimed to analyze the effectiveness and safety of microplasma beam in the treatment of facial depression scars.Methods.106 patients with facial depression scars treated in the hospital between january 2017 and september 2021 were selected as the observation subjects.According to different treatment methods, the patients were divided into the control group (receiving ultrapulsed carbon dioxide lattice laser treatment, n = 51) and the observation group (undergoing plasma beam treatment, n = 55).The two groups were treated for 6 months, and the treatment effects were compared between the two groups.The visual analogue scale (vas) was used to compare the pain between the two groups, and the duration of pain and the time of scab shedding were recorded.The improvement of scars was compared between the two groups according to the evaluation clinique des cicatrices d’ acne (ecca), and the adverse reactions during treatment were compared between the two groups.Results.A clinical effective rate of 94.55% in the observation group was higher than a clinical effective rate of 82.35% in the control group ( p &lt; 0.05 ).The vas score in the observation group was lower than that in the control group, and the pain duration and the scab shedding time were shorter than those in the control group ( p &lt; 0.05 ).Ecca scores in the observation group after twice and 3 times of treatments were lower than those in the control group ( p &lt; 0.05 ).The total incidence rate of adverse reactions of 10.91% in the observation group was lower, whereas it was 25.49% in the control group ( p &gt; 0.05 ).Conclusion.Plasma beam has a significant efficacy in the treatment of facial depressed scars, and it has mild pain, quick recovery, and high safety.Clinical trial registration number.The clinical trial registration number is t2017081.

Journal: Emergency Medicine International (2022)
Publication types: Clinical Study;
Effect of Hyperbaric Oxygen Therapy on Sleep Quality, Drug Dosage, and Nerve Function in Patients with Sleep Disorders after Ischemic Cerebral Stroke

To explore the effects of hyperbaric oxygen therapy (hot) on sleep quality, drug dosage, and nerve function in patients with sleep disorders after ischemic cerebral stroke (ics).Methods.A total of 120 patients with acute ics and sleep disorders who came to our hospital for treatment from january 2019 to october 2021 were selected and divided into control and observation groups according to the random numbering method, with 60 cases in each group.Both groups were treated with sertraline and eszopiclone for treating insomnia.The control group was given routine treatment for ics, and the observation group was additionally treated with hot in addition to the control group.The sleep quality, the use of sleep medication, the neurological function score, and the levels of serum tumor necrosis factor-α (tnf-α), endothelin (et), and neuropeptide y (npy) before and after treatment were compared between the two groups.Results.The levels of tnf-α, et and npy were not significantly different between the two groups of patients before treatment ( p &gt; 0.05 ), and all of the above indicators decreased significantly in both groups after treatment, with the observation group being lower than the control group ( p &lt; 0.05 ).There was no significant difference in the sleep quality scores of psqi, ess, and sbq between the two groups before treatment ( p &gt; 0.05 ), and the above indicators decreased significantly in both groups after treatment, with the observation group being lower than the control group ( p &lt; 0.05 ).There was no significant difference in the dose of sleep medication used in the first day of treatment between the two groups ( p &gt; 0.05 ), and the amount of sleep medication used in the observation group was significantly less than that in the control group after 14 d of treatment ( p &lt; 0.05 ).There was no significant difference in the nihss scores between the two groups before treatment ( p &gt; 0.05 ), and the scores of both groups decreased after treatment, and the scores of the observation group were significantly lower than those of the control group ( p &lt; 0.05 ).Conclusion.Compared with routine treatment, the addition of hot to treat patients with sleep disorders after ics can significantly improve their sleep quality, reduce dosage of sleep drugs, reduce inflammatory level of brain tissue and nerve function damage, and improve their prognosis.Trial registration.This study was registered in the ea2019056

Journal: Emergency Medicine International (2022)
Publication types: Clinical Study;
Effect of Cognitive Behavioral Therapy on Stress Disorder, Cognitive Function, Motor Function, and Daily Living Ability of Patients with a Traumatic Brain Injury

The aim of the study is to observe the effects of cognitive behavioral therapy on stress disorder, cognitive function, motor function, and daily living ability of traumatic brain injury (tbi) patients.Methods.84 patients with tbi admitted to our hospital from june 2019 to may 2021 were selected as the research subjects.They were divided into a control group (from june 2019 to may 2020) and an observation group (from june 2020 to may 2021), with 42 cases in each group.The control group received routine intervention; the observation group received cognitive behavioral therapy on the basis of the control group.Before and after intervention, the posttraumatic stress disorder (ptsd), cognitive function, motor function, and daily living ability of the two groups were observed.Results.After intervention, the ptsd-self-rating scale (ptsd-ss) scores of both groups were lower than those before intervention, and the ptsd-ss scores of the observation group were lower than those of the control group p &lt; 0.05 .After intervention, the scores of the montreal cognitive assessment (mo ca) scale, fugl-meyer assessment (fma), and modified barthel index (mbi) in both groups were higher than those before intervention, and the scores of mo ca, fma, and mbi in the observation group were higher than those in the control group p &lt; 0.05 .Conclusion.The application of cognitive behavioral therapy to tbi patients is beneficial to reduce the degree of ptsd and improve cognitive function, motor function, and daily living ability, which is worthy of clinical application.

Journal: Emergency Medicine International (2022)
Publication types: Research Article;
Early Postoperative Pain Control and Inflammation for Total Knee Arthroplasty: A Retrospective Comparison of Continuous Adductor Canal Block versus Single-Shot Adductor Canal Block Combined with Patient-Controlled Intravenous Analgesia

The aim of this study was to compare pain control and inflammation among patients who received a continuous adductor canal block (cacb) versus single-shot adductor canal block (sacb) combined with patient-controlled intravenous analgesia (pcia) for total knee arthroplasty (tka) analgesia in the first two days after surgery.Design.Matched cohort retrospective study.Setting.University hospital.Patients.One hundred fifty-six patient charts were included in this study: 78 patients with cacb in group a and 78 patients with sacb combined with pcia in group b.Patients were matched according to age, body mass index, and american society of anesthesiologists class.Measurements.The primary outcome of the study was visual analogue scale (vas) pain scores before operation (pre) and at postoperative 6 (poh6), 12 (poh12), 24 (poh24), 30 (poh30), 36 (poh36), and 48 hours (poh48).Secondary outcomes included patient-controlled bolus, time of first postoperative ambulation, range of knee flexion and extension, inflammation cytokines on pre and poh48, percentage of remedial analgesics treatment, incidence of adverse events and complications, hospital stay and cost, and numerical rating scale (nrs) satisfaction scores at discharge.Main results.Mean vas scores at rest and with motion were lower in group b than in group a on all postoperative hours.At poh30, compared with group a (1.1 ± 0.6), mean vas scores at rest in group b (0.9 ± 0.4) were lower ( p = 0.048 ), and compared with group a (2.6 ± 0.7), mean vas scores with motion in group b (2.2 ± 0.8) were lower ( p = 0.001 ).The number of patient-controlled bolus was 4.3 ± 1.6 (95% ci 3.9–4.6) in group a and 3.1 ± 1.3 (95% ci 2.8–3.4) in group b, respectively ( p &lt; 0.001 ).Patients in group b displayed better functional recovery and inflammation results at poh48 than group a with respect to range of knee flexion and extension (117.8 ± 10.9° vs.125.2 ± 9.4°, p &lt; 0.001 ) and inflammation cytokines, including erythrocyte sedimentation rate (esr), c-reactive protein (crp), and interleukin-6 (il-6) ((43.8 ± 16.1) vs.(36.8 ± 13.2), p = 0.003 ; (34.9 ± 9.4 mg/l) vs.(29.6 ± 10.6 mg/l), p = 0.001 ; (21.3 ± 8.7 pg/ml) vs.(14.0 ± 7.0 pg/ml), p &lt; 0.001 )).Conclusion.Sacb combined with pcia in the first two days of patients undergoing tka has better analgesic and beneficial effects on functional recovery and inflammation.

Journal: Emergency Medicine International (2022)
Publication types: Research Article;
Discovery and Discrimination of Bridge Engineering Safety Issues by BIM Virtual Scene Combined with Robotic Mapping

All along, safety accidents in the field of bridge construction have continued to arise, costing society's development financial and material resources and taking away people’s personal safety, turning into an urgent need for safety managers in the field to solve the subject research.Researchers look forward to continued innovative exploration to find new ways of working safely and using them in the construction industry.On this basis, bim virtual scenes are introduced to create a universal scene specification dataset in the field of bridge construction and a dataset of unsafe potential hazard characteristics in the field of bridge construction.Nanobots are artificial intelligence systems built to simulate biological nanomachine constructions in life activities and important biological events in life processes.In this paper, bim virtual scenarios incorporating intelligent nanomaterial robot mapping technology are migrated to bridge engineering safety management.According to the collected construction scene images and bim (building information model) virtual scenes, build the construction scene dataset, use intelligent robots to obtain construction scenes, and load them into the trained construction on-the-spot neural network modeling to complete the bridge construction scene identification safety discrimination to select more comprehensive and more stringent management solutions as safety management personnel management methods on-the-spot.

Journal: Journal of Robotics (2023)
Publication types: Research Article;
Diagnosis of Cervical Intraepithelial Neoplasia and Invasive Cervical Carcinoma by Cervical Biopsy under Colposcopy and Analysis of Factors Influencing

To explore the diagnosis of cervical intraepithelial neoplasia (cin) and invasive cervical carcinoma (icc) by cervical biopsy under colposcopy and analyze the factors influencing the detection.Methods.The clinical data of 134 cin confirmed by colposcopy biopsy in our hospital from june 2018 to october 2019 and subsequent leep treatment were analyzed retrospectively.All patients were diagnosed pathologically after the operation.The diagnosis of cin by cervical biopsy under colposcopy was observed.The influencing factors of cin and icc detected by colposcopy biopsy were analyzed by the pathological results of loop electrosurgical excision procedure (leep) as the gold standard.Results.After leep, the number of the no intraepithelial or malignant lesions (nilm) or icc were higher than that of colposcopy biopsy, and cin-iii was lower than that of colposcopy biopsy, the differences were all statistically significant ( p &lt; 0.05 ).Among the 134 patients, the coincidence rate between colposcopy biopsy and leep examination results was 79.10% (106/134), and postoperative pathological findings showed that there were 13 cases (9.70%) with the pathological upgrade and 19 cases (14.18%) with pathological decrease.Multivariate logistic analysis showed that the image quality of colposcopy image, atypical blood vessels, biopsy sampling method, and visible lesion area of the cervix were the independent influencing factors for the detection of cin and icc by colposcopy biopsy ( p &lt; 0.05 ).Conclusion.Cin and icc can be diagnosed by colposcopy cervical biopsy and postoperative histopathology.However, there are still some missed and misdiagnosed cervical biopsies under colposcopy, and the combined detection of the two can further ensure the diagnosis rate.The clinical registration number is e2018091.

Journal: Emergency Medicine International (2022)
Publication types: Research Article;
Development of Microneedle Patch Loaded with Bacopa monnieri Solid Lipid Nanoparticles for the Effective Management of Parkinson’s Disease

The demand for drug delivery systems (dds) to treat parkinson’s disease (pd) is still high, and microneedle (mn) assisted transdermal dds offers enormous potential.Herbal products for pd have been shown to have antioxidant effects in reducing dopaminergic neurons from degeneration.Here, we attempted to incorporate solid lipid nanoparticles (slns) of bacopa monnieri into dissolvable microneedle arrays and evaluate its neuroprotective activity.The bloodless and painless microneedle arrays through the transdermal route deliver the drug across the blood‐brain barrier at the desired concentration.The quality by design (qb d) approach was employed for optimizing the slns formulations.The mechanical strength, in vitro release studies, ex-vivo permeation investigation, skin irritation test, histopathological studies, biochemical studies, and behavioural tests slns loaded microneedle arrays were performed.The microneedle patches obtained were shown to be mechanically robust and were also found to be nonirritant with a decreased degree of bradykinesia, high motor coordination, and balance ability.Compared to systemic delivery systems, such an mn method can achieve a considerably lower effective dose and allow long‐term home‐based treatment.

Journal: Bioinorganic Chemistry and Applications (2022)
Publication types: Research Article;
Detection and Significance of Cell-Free DNA Mutation in Pleural Effusion in Patients with Advanced NSCLC

To detect egfr/kras genes in pleural effusion cell-free dna in patients with advanced non-small-cell lung cancer (nsclc) and to explore the clinical significance of egfr/kras mutation status in pleural effusion.Methods.A retrospective collection was performed on the specimens of pleural effusion and matched tissues from 50 patients with advanced nsclc admitted to the hospital between january 2019 and january 2021.Dna mutation status of egfr/kras in different specimens was detected and compared by pyrosequencing.The clinicopathological data and follow-up data of survival were collected.The relationship between dna mutation and clinicopathological characteristics and prognosis was analyzed.Results.In the 50 pleural effusion specimens, there were 22 cases (44.00%) with egfr mutations (19/21 exon mutations), including 12 cases with egfr19 deletion mutation and 10 cases with egfr21 exon l858r mutation.There were 6 cases (12.00%) with kras mutations (single-base substitution mutations), including 4 cases with 12-codon mutation and 2 cases with 13-codon mutation.In the 50 tissue specimens, there were 24 cases (48.00%) with egfr mutations and 4 cases (8.00%) with kras mutations.There was no significant difference between pleural effusion specimens and tissue specimens, with good consistency (kappa = 0.920–0.779, p &gt; 0.05 ).Egfr mutation in pleural effusion was related to smoking history, types of pathological tissues, and lymph node metastasis ( p &lt; 0.05 ).The incidence of egfr mutation was higher in nonsmokers, patients with lung adenocarcinoma, and patients with lymph node metastasis.The carcinoembryonic antigen (cea) in patients with egfr mutation was higher than that with wild-type egfr, while the level of cytokeratin 19 fragment (cy21-1) was lower than that with wild-type egfr ( p &lt; 0.05 ).The 1-year overall survival rate in the egfr mutation group was significantly higher than that in the egfr wild group (68.18% vs.42.86%) (hr = 0.419, 95% ci = 0.178–0.989, and p &lt; 0.001 ).Conclusion.For the detection of egfr gene mutation, the results of the pleural effusion specimens and the tumor pathological tissue specimens were well consistent and the detection of pleural effusion could be used as an alternative method when tissue specimens cannot be obtained.Egfr gene mutations are present in majority in patients with advanced nsclc.The incidence of egfr mutation is higher in nonsmokers, patients with lung adenocarcinoma, those with lymph node metastasis, those with high-expression cea, and those with low-expression cy21-1.The prognosis is better in patients with egfr mutation.

Journal: Emergency Medicine International (2022)
Publication types: Research Article;
Intelligent Garden Planning and Design Based on Agricultural Internet of Things

As the application of the internet of things technology continues to deepen in various fields, it also continues to develop in the agricultural field and the agricultural landscape.This article uses the agricultural internet of things to conduct an in‐depth analysis and research on the planning and design of smart gardens and combines field research and project practice on the basis of theoretical analysis.Through the combination of agricultural internet of things technology and agricultural landscape, the planning and design of smart gardens are studied.The theories used include internet of things technology, agricultural industrialization theory, sustainable agricultural development theory, new rural construction theory in agricultural disciplines, ecotourism theory, tourism psychology theory in tourism disciplines, landscape ecology theory, landscape aesthetics theory, and garden planning and design theory.From related theories to planning and design practice, a more systematic study of the smart park has been carried out to provide scientific guidance for the agriculture of the smart park.To provide scientific guidance for the planning and design of agricultural io t of smart gardens, the theoretical system of planning and design of smart gardens based on the integration of agricultural io t is proposed and systematically elaborated, including its concept, characteristics, related theories, and guidance methods.

Journal: Complexity (2021)
Publication types: Research Article;
Intelligent Environmental Art Design Combining Big Data and Artificial Intelligence

The widespread use of artificial intelligence in the field of design teaching has become a development trend, and for the art design profession, we should conform to and actively adapt to this development trend, change the original teaching mode, innovate their own teaching methods, constantly enrich the teaching methods, so as to improve the quality of teaching, and constantly cultivate high‐quality art design talents in the new era.For the subject students, they grow up under the internet.They are more affectionate to many new technologies, and the traditional teaching methods have some problems to meet their learning needs, so it is very necessary to introduce artificial intelligence in teaching.In this paper, we will discuss the optimization of the curriculum system of art design in higher education institutions in the context of artificial intelligence.The purpose of guiding the innovation of environmental art design thinking is to stimulate students’ learning ability and innovation ability and learn to use design ideas in practice.Integrating design thinking with artificial intelligence gets four innovative ways of culture, form, function, and emotion in terms of innovation at the design thinking level; in terms of thinking innovation guidance, it gets the guidance of role transformation and model practice, integrating artificial intelligence with environmental art design thinking, designing interactive spaces more in line with the times, and promoting the harmonious development of human and nature.

Journal: Complexity (2021)
Publication types: Research Article;
Information Fusion Algorithm for Big Data in Digital Publishing Industry Chain

This paper studies the information of big data in the digital publishing industry chain and adopts advanced algorithms for its fusion calculation.The basic theory of digital publishing ecological chain is dissected, the construction requirements, construction methods, and construction paths of digital publishing ecological chain are analysed, and feasible construction measures are proposed.It also defines the connotation of the fusion of knowledge services between publishing institutions and libraries in the digital era; then analyses the characteristics and principles of the fusion of knowledge services between publishing institutions and libraries in the digital era; and finally sorts out the theoretical foundations such as synergy theory, information integration service theory, and game theory.Meanwhile, this paper also studies the flow of digital publishing resources and empirically analyses the eco‐efficiency of digital publishing eco‐chain by using metabolic network analysis, population analysis, and life cycle analysis, and it finds the eco‐efficiency problems of the existing e‐book eco‐chain from its analysis.Finally, the imbalance in the digital publishing ecological chain and its hazards are analysed, and specific regulation and optimization measures are proposed.The research in this paper makes up for the deficiencies of related studies and can well solve the problems that exist in the previous and provide theoretical support for the healthy development of digital publishing enterprises.

Journal: Complexity (2021)
Publication types: Research Article;