syedzayyan/paper_mill_benchmark huggingface dataset:
The criticality of tourism development, economic complexity, and country security on ecological footprint.

What kinds of countries are likely to be prosperous and have a sustainable environment at the same time?How might countries reorient their policy setting to be more capable of suppressing environmental degradation?To explore these questions, this research examines data from 99 countries for 2006-2017, takes the six major forms of ecological footprint (ef) as indicators of environmental quality, and probes the environmental kuznets curve (ekc) hypothesis via quantile regression approach.We find that tourism development leads to greater environmental degradation, with tourism development particularly corresponding to more usage of carbon absorption land and cropland.The lower the country security is, the better is the environmental quality.Economic complexity also worsens environmental quality.However, country security weakens the negative influence of tourism development and economic complexity on environmental quality, specifying that better country security stalls the negative impact of tourism and economic complexity on environmental quality.Results mostly support the tourism- and country security-induced ekc hypotheses in fishing footprint, whereas economic complexity-induced ekc is generally validated in cropland footprint.Finally, we present that tourism arrivals, economic complexity, and country security have varying impacts across diverse ecological footprint quantiles.

Journal: Environmental science and pollution research international (2022)
Publication types: Journal Article
Genotyping of Dombrock blood group system in blood donors from Saudi Arabia: A single-center study.

S to establish the frequency of dombrock (do) blood group genotypes in western saudi arabians and to compare the findings with other populations in the 1000 genomes database.Methods this cross-sectional study was carried out between december 2018 and february 2019.A total of 440 blood samples in ethylenediaminetetraacetic acid tubes were collected from unrelated saudi arabian blood donors from jeddah, saudi arabia.Deoxyribonucleic acid was extracted, followed by an allele-specific polymerase chain reaction for do*01 and do*02 alleles (c.793a>g,rs11276).The allele and genotype frequencies were counted and compared to those in other populations using the chi-squared test with bonferroni adjustments.Results the do allele frequencies for blood donors from western saudi arabia were 0.432 for do*01 and 0.568 for do*02.The do genotype frequencies were 0.182 for do*01/01, 0.318 for do*02/02, and 0.5 for do*01/02.The do genotype frequencies were similar to europeans, americans, and south asians but significantly different from the genotype frequencies of africans and east asians reported in the 1000 genomes database.Conclusion dombrock genotype frequencies in the western saudi arabian population were different from africans and east asians but not from europeans, americans, and south asians.This study contributes to a genotyped blood donor database and may advance transfusion safety for patients in western saudi arabia.

Journal: Saudi medical journal (2022)
Publication types: Journal Article
Discovery of novel Glutaminase allosteric inhibitors through drug repurposing and comparative MMGB/PBSA and molecular dynamics simulation.

Gls1 enzymes (glutaminase c (gac) and kidney-type glutaminase (kga)) are gaining prominence as a target for tumor treatment including lung, breast, kidney, prostate, and colorectal.To date, several medicinal chemistry studies are being conducted to develop new and effective inhibitors against gls1 enzymes.Telaglenastat, a drug that targets the allosteric site of gls1, has undergone clinical trials for the first time for the therapy of solid tumors and hematological malignancies.A comprehensive computational investigation is performed to get insights into the inhibition mechanism of the telaglenastat.Some novel inhibitors are also proposed against gls1 enzymes using the drug repurposing approach using 2d-fingerprinting virtual screening method against 2.4 million compounds, application of pharmacokinetics, molecular docking, and molecular dynamic (md) simulations.A tip3p water box of 10 å was defined to solvate both enzymes to improve md simulation reliability.The dynamics results were validated further by the mmgb/pbsa binding free energy method, rdf, and afd analysis.Results of these computational analysis revealed a stable binding affinity of telaglenastat, as well as an fda approved drug astemizole (ic50∼ 0.9 n m) and a novel para position oriented methoxy group containing chembridge compound (chem-64284604) that provides an effective inhibitory action against gac and kga.

Journal: Computers in biology and medicine (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Pulmonary Mycobacterium abscessus complex in children with cystic fibrosis: A practical management guideline.

The treatment of mycobacterium abscessus complex (mabsc) pulmonary infections is an emerging challenge in patients with cystic fibrosis (cf).Multidrug therapy for prolonged durations is required and carries the significant burden of drug-related toxicity, cost and selective pressure for multiresistant bacteria.International guidelines acknowledge that clinical and in vitro data to support treatment regimens are limited, particularly in children.As part of a collaboration between the infectious diseases and respiratory units at our institution, we have developed a modified treatment guideline that aims to balance the aims of mabsc eradication and slowing disease progression with minimising drug toxicity and resistance.The outcomes of this treatment approach will be monitored and reported.In this manuscript, we discuss the available evidence for treatment choices and present our treatment guideline for paediatric patients with cf and mabsc infection.

Journal: Journal of paediatrics and child health (2019)
Publication types: Journal Article;Review
A comparison of farming- and non-farming-related suicides from the United States' National Violent Deaths Reporting System, 2003-2016.

Farmers are at higher risk of suicide than other occupations and the general population.The complex suicide risk factors have not been examined in a large, population-wide study across a significant time period.This observational study draws on existing data from the united states' national violent death reporting system (nvdrs), including 140,523 farming- or non-farming-related suicide decedents between 2003 and 2016 from across 40 states."farming-related" decedents included 2,801 suicides.Farmers had higher odds of being male, older, less well-educated, and american indian/alaska native.Farmers had higher odds of using firearms and-when farmers used a gun-higher odds of using a long-arm weapon.Farmers had lower odds of having a known mental health condition or job problem, and lower odds of having made a previous suicide attempt or leaving a suicide note.Findings highlight the complexity of suicide risk within the context of farming in the united states and reinforce the need for tailored prevention efforts; employing means restriction of firearms; and emphasizing that traditional risk factors may not be as common in the farming population.

Journal: Suicide & life-threatening behavior (2021)
Publication types: Journal Article;Observational Study
Multivalent, Soluble Nano-Self Peptides Increase Phagocytosis of Antibody-Opsonized Targets while Suppressing "Self" Signaling.

Macrophages engulf "foreign" cells and particles, but phagocytosis of healthy cells and cancer cells is inhibited by expression of the ubiquitous membrane protein cd47 which binds sirpα on macrophages to signal "self".Motivated by some clinical efficacy of anti-cd47 against liquid tumors and based on past studies of cd47-derived polypeptides on particles that inhibited phagocytosis of the particles, here we design soluble, multivalent peptides to bind and block sirpα.Bivalent and tetravalent nano-self peptides prove more potent (keff∼ 10 n m) than monovalent 8-mers as agonists for phagocytosis of antibody opsonized cells, including cancer cells.Multivalent peptides also outcompete soluble cd47 binding to human macrophages, consistent with sirpα binding, and the peptides suppress phosphotyrosine in macrophages, consistent with inhibition of sirpα's "self" signaling.Peptides exhibit minimal folding, but functionality suggests an induced fit into sirpα's binding pocket.Pre-clinical studies in mice indicate safety, with no anemia that typifies clinical infusions of anti-cd47.Multivalent nano-self peptides thus constitute an alternative approach to promoting phagocytosis of "self", including cancer cells targeted clinically.

Journal: ACS nano (2020)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.
Serotonin facilitates late-associative plasticity via synaptic tagging/cross-tagging and capture at hippocampal CA2 synapses in male rats.

Synaptic plasticity in the hippocampal cornu ammonis (ca) subfield, ca2, is tightly regulated.However, ca2 receives projections from several extra-hippocampal modulatory nuclei that release modulators that could serve to fine-tune plasticity at ca2 synapses.Considering that there are afferent projections from the serotonergic median raphe to hippocampal ca2, we hypothesized that the neuromodulator serotonin (5-hydroxytryptamine; 5-ht) could modulate ca2 synaptic plasticity.Here, we show that bath-application of serotonin facilitates the persistence of long-term depression (ltd) at the ca3 schaffer collateral inputs to ca2 neurons (sc-ca2) when coupled to a weak low frequency electrical stimulation, in acute rat hippocampal slices.The observed late-ltd at sc-ca2 synapses was protein synthesis- and n-methyl-d-aspartate receptor (nmdar)-dependent.Moreover, this late-ltd at sc-ca2 synapses paves way for the associative persistence of transient forms of ltd as well as long-term potentiation to long-lasting late forms of plasticity through synaptic tagging and cross-tagging respectively, at the entorhinal cortical synapses of ca2.We further observe that the 5-ht-mediated persistence of activity-dependent ltd at sc-ca2 synapses is blocked in the presence of the brain-derived neurotrophic factor scavenger, trk b/fc.

Journal: Oxford open neuroscience (2022)
Publication types: Journal Article
DNA methylation status of MutS genes in ameloblastoma.

S ameloblastoma is an odontogenic epithelial tumour with a low expression of mismatch repair system components.We aimed to investigate the methylation status of the genes msh2, msh3 and msh6 (mut s group) in conventional ameloblastomas.Materials and methods the ameloblastoma and dental follicle samples (n = 10 each) were collected from 20 different patients.Each ameloblastoma sample was sectioned into two fragments: one was paraffin-embedded while the other one, likewise the dental follicle samples, was fixed in rnalater and frozen at -196°c.All frozen samples were investigated for the mut s genes methylation levels, using the enzymatic restriction digestion and quantitative real-time pcr (q pcr) assay.The ameloblastoma paraffin-embedded samples were submitted to immunohistochemical reactions for mut s proteins detection and digitally quantification.Correlation analyses were performed between the immunohistochemical results and the respective gene methylation percentage.Results there are no significant differences between the mut s genes methylation levels in the ameloblastoma and the dental follicle.However, a strong negative correlation was found between msh2 and msh6 gene methylation status and their respective proteins expressions evaluated by immunohistochemistry.Conclusion our results show that the genes methylations is in part responsible for decreasing the expression of msh2 and msh6 genes in ameloblastoma.

Journal: Oral diseases (2022)
Publication types: Journal Article
Urban Biomimicry for Flood Mitigation Using an Ecosystem Service Assessment Tool in Central Wellington, New Zealand.

Many cities are vulnerable to flooding due to their high proportion of impervious surfaces and lack of vegetated land cover.This vulnerability will often be exacerbated by changing rainfall and storm patterns due to climate change.Using the principles of urban biomimicry, this study aims to show an ecosystem service-based approach to designing an urban green infrastructure network for stormwater management in densely built areas that more closely emulates natural hydrology processes.Nature braid (next-generation luci) is an ecosystem services assessment tool that was used to simulate flood mitigation ecosystem services in a 13.7 km2urban water catchment in wellington, aotearoa new zealand.The simulation results revealed that 59% of the catchment does not contain or benefit from flood-mitigating land cover features.Adding 0.6 km2(4% of the catchment) of green roofs alongside major stormwater flow paths resulted in a nearly three-fold decrease (11%) in the unmitigated flooding area.These results suggest that green roofs could help manage stormwater and mitigate flooding in the densely built areas of the catchment.Using ecosystem service assessment tools, like nature braid, can inform the design of more regenerative and resilient urban green infrastructure networks that help mitigate climate change impacts on urban residents.

Journal: Biomimetics (Basel, Switzerland) (2022)
Publication types: Journal Article
Systems of support for foreign-born TB patients and their family members.

Setting adverse social determinants of health for people who are foreign-born are key drivers of tb-related disparity, particularly in low-incidence countries.Patients diagnosed with infectious tb and their family members must confront psychosocial challenges which may deepen pre-existing health inequities.However, little is known about patient and family members' perspective on these experiences.Objective to explore the infectious tb experience of patients and family members who are foreign-born.Design this study formed one component of an ecologically framed, qualitative case study conducted in calgary, ab, canada.Data were collected using semi-structured interviews, chart review and field notes, and analysed thematically.Results eight families were represented in the sample comprised of six patients and 13 family members.Many patients and family members experienced high levels of fear and stress for months following the patient's diagnosis.Isolation was pervasive and multifaceted for both patients and family members.Intra-family support was critical for managing during early stages when the situation was most challenging.Support from outside the family was not prominent and attempts to obtain support from government programmes for paid sick leave and health insurance were mostly unsuccessful.Conclusion patients and family members who are foreign-born experience multidimensional isolation as a result of tb stigma, language barriers and poor access to government programmes.Tb programmes cannot meet family needs alone and systems of support should be created through collaboration with government institutions, and organisations serving ethnocultural communities.

Journal: Public health action (2022)
Publication types: Journal Article
A sensitive ratiometric biosensor for determination cardiac troponin I of myocardial infarction markers based on N, Zn-GQDs.

A sensitive unlabeled ratiometric biosensor was developed to the detection of cardiac troponin i (c tn i).This biosensor was established by using the glassy carbon electrode coated with graphene oxide to form a platform bonded with n, zn co-doped graphene quantum dots (n, zn-gqds).The n, zn-gqds was successfully prepared as the raw materials of graphite powder and characterized.Antibodies of c tn i were bonded to the surface of n, zn-gqds as the nanoprobe by amide bonds.The signals of electrochemiluminescence (ecl) and differential pulse voltammetry (dpv) were exposed to decrease in the presence of c tn i, which caused the signal substance to move farther away from the electrode.It was found that the immune complex layer attenuated the intensity of ecl and dpv which could be used as the good overall signal for determining concentration of c tn i.The ratiometric biosensor had a good response to c tn i with the detection limit is 4.59 pg l-1in the concentration range of 10-106pg l-1.The developed method was evaluated for the detection of c tn i in human serum, and the obtained results were consistent compared to the reference values obtained by hospital standard enzyme linked immunoassay (elisa) with 9.09%-11.1% of rsd.Our findings suggested that this ratiometric biosensor could be used to the detection of c tn i in human serum with lower cost and higher sensitivity, it also might be better potential application prospect based on n, zn-gqds to detect other biomarkers.

Journal: Talanta (2022)
Publication types: Journal Article
Clinical Efficacy Protocol of Yinhuapinggan Granules: A Randomized, Double-Blind, Parallel, and Controlled Clinical Trial Program for the Intervention of Community-Acquired Drug-Resistant Bacterial Pneumonia as a Complementary Therapy.

Community-acquired bacterial pneumonia (cabp) is an important health care concern in the worldwide, and is associated with significant morbidity, mortality, and health care expenditure.streptococcus pneumoniaeis the most frequent causative pathogen of cabp.Common treatment for hospitalized patients with cabp is empiric antibiotic therapy using β-lactams in combination with macrolides, respiratory fluoroquinolones, or tetracyclines.However, overuse of antibiotics has led to an increased incidence of drug-resistant s.pneumoniae, exacerbating the development of community-acquired drug-resistant bacterial pneumonia (cdbp) and providing a challenge for physicians to choose empirical antimicrobial therapy.methods:traditional chinese medicine (tcm) is widely used as a complementary treatment for cdbp.yinhuapinggangranules (yhpg) is widely used in the adjuvant treatment of cdbp.Experimental studies and small sample clinical trials have shown that yhpg can effectively reduce the symptoms of cdbp.However, there is a lack of high-quality clinical evidence for the role of yhpg as a complementary drug in the treatment of cdbp.Here, we designed a randomized, double-blind, placebo-controlled clinical trial to explore the efficacy and safety of yhpg.A total of 240 participants will be randomly assigned to the yhpg or placebo group in a 1:1 ratio.Yhpg and placebo will be added to standard treatment for 10 days, followed by 56 days of follow-up.The primary outcome is the cure rate of pneumonia, and the secondary outcomes includes conversion rate of severe pneumonia, lower respiratory tract bacterial clearance, lactic acid (lc) clearance rate, temperature, c-reactive protein (crp), criticality score (smart-cop score), acute physiological and chronic health assessment system (apacheii score) and clinical endpoint events.Adverse events will be monitored throughout the trial.Data will be analyzed according to a pre-defined statistical analysis plan.This research will disclose the efficacy of yhpg in acquired drug-resistant pneumonia.clinical trial registration: identifier chi ctr2100047501.

Journal: Frontiers in pharmacology (2022)
Publication types: Journal Article
Characteristics of the Gut Microbiome and Its Relationship With Peripheral CD4+T Cell Subpopulations and Cytokines in Rheumatoid Arthritis.

This study investigated the association between intestinal microbiota abundance and diversity and cluster of differentiation (cd)4+t cell subpopulations, cytokine levels, and disease activity in rheumatoid arthritis ra.A total of 108 rheumatoid arthritis (ra) patients and 99 healthy control (hc) subjects were recruited.Picrust2 was used for functional metagenomic predictions.Absolute counts of peripheral cd4+t cell subpopulations and cytokine levels were detected by flow cytometry and with a cytokine bead array, respectively.Correlations were analyzed with the spearman rank correlation test.The results showed that the diversity of intestinal microbiota was decreased in ra patients compared to hcs.At the phylum level, the abundance of firmicutes, fusobacteriota, and bacteroidota was decreased while that of actinobacteria and proteobacteria was increased and at the genus level, the abundance of faecalibacterium,blautia, and escherichia-shigellawas increased while that of bacteroidesand coprococcuswas decreased in ra patients compared to hc subjects.The linear discriminant analysis effect size indicated that bifidobacteriumwas the most significant genus in ra.The most highly enriched kyoto encyclopedia of genes and genomes pathway in ra patients was amino acid metabolism.The relative abundance of megamonas,monoglobus, and prevotellawas positively correlated with cd4+t cell counts and cytokine levels; and the relative numbers of regulatory t cells (tregs) and t helper (th17)/treg ratio were negatively correlated with disease activity in ra.These results suggest that dysbiosis of certain bacterial lineages and alterations in gut microbiota metabolism lead to changes in the host immune profile that contribute to ra pathogenesis.

Journal: Frontiers in microbiology (2022)
Publication types: Journal Article
Explain the challenges of evacuation in floods based on the views of citizens and executive managers.

Flood is one of the natural hazards that causes a lot of human and financial losses.Emergency evacuation in the response phase is necessary to reduce damage.The present study was conducted to explain the challenges related to evacuation in floods based on the views of citizens and executive managers.Materials and methods in this study, a qualitative research method with a contractual content analysis approach was used.27 participants including 10 citizens and 17 executive managers were included in the study by purposive sampling.Semi-structured interviews were used to collect data.In order to have confidence the validity of the results, rigor was certified by using the guidelines suggested by guba and lincoln for making trustworthiness.The duration of the interview was between 45 min and 60 min.The interviews were handwritten by line-by-line content analysis and then analyzed.Results data analysis led to the extraction of 6 main categories with 14 sub-categories including: lack of primary warning system (with 2 sub-categories, lack of national early warning system and lack of attention to early warning), insufficient resources (with 4 sub-categories, lack of equipment, lack of manpower human resources, inadequate allocation of financial resources and lack of information resources), problems related to unpreparedness (having 2 sub-categories, lack of pre-determined program and lack of attention to public education), problems related to emergency housing (having 2 sub-categories, lack of housing program and lack of attention to indigenous culture in housing), lack of risk perception (has 2 sub-categories of people's belief in floods and officials' belief in flood) and problems related to lack of coordination (has 2 sub-categories of internal disharmony and external disharmony).Conclusion to increase evacuation, it is necessary to identify the relevant challenges.Establishing an early warning system and evacuation plan, supply of resources, and increase risk perception and coordination can increase the speed of evacuation and reduce the financial and human losses caused by floods.

Journal: Heliyon (2022)
Publication types: Journal Article