syedzayyan/paper_mill_benchmark huggingface dataset:
Effective mitigation of gadolinium deposition using the bidentate hydroxypyridinone ligand Me-3,2-HOPO.

With the extensive usage of gadolinium-based contrast agents (gbcas) in magnetic resonance imaging (mri), gadolinium deposition has been observed in the brain, kidneys, liver,etc., and this is also closely related to the development of nephrogenic systemic fibrosis (nsf) in patients with renal dysfunction.Chelation, thereby promoting the elimination of deposited gd(iii), seems to be promising for alleviating these problems.Despite many ligands suitable for chelation therapy having been studied, the decorporation of transition metals (e.g.iron, copper, lead,etc.) and actinides (e.g.uranium, plutonium,etc.) has long been a primary concern, whereas the study of gd(iii) has been extremely limited.Due to their excellent metal binding abilitiesin vivoand therapeutic effects toward neurodegenerative diseases, bidentate hydroxypyridinone ligands are expected to be able to remove gd(iii) from the brain, kidneys, bones, and liver.Herein, the gd(iii) decorporation efficacy of a bidentate hydroxypyridinone ligand (me-3,2-hopo) has been evaluated.The complexation behavior between me-3,2-hopo and gd(iii) in solution and solid states was characterized with the assistance of potentiometric titration and x-ray diffraction techniques, respectively.Solution-based thermodynamic studies illustrate that the dominant species of complex between gd(iii) and me-3,2-hopo (hl) is gd l2+(logβ120= 11.8 (3)) at p h 7.4.The structure of the gd-me-3,2-hopo crystal obtained from a room temperature reaction reveals the formation of a gd(iii) dimer that is chelated by four ligands as a result of metal ion hydration and ligand complexation.Cellular gd(iii) removal assays illustrate that me-3,2-hopo could effectively reduce final amounts of gadolinium by 77.6% and 66.1% from rat renal proximal tubular epithelial (nrk-52e) cells and alpha mouse liver 12 (aml-12) cells, respectively.Our current results suggest the potential of bidentate hopo ligands as an effective approach to treat patients suffering from gd(iii) toxicity.

Journal: Dalton transactions (Cambridge, England : 2003) (2022)
Publication types: Journal Article
Flexible ureteroscopy with ultrasound guidance for the treatment of parapelvic renal cysts: A complementary approach for locating the cystic wall.

Flexible ureteroscopic incision and drainage is a relatively new surgical method for treating parapelvic cysts.Considering that the intraoperative localization of the cyst may fail with a flexible ureteroscope, we use an innovative ultrasound-guided method to locate the cystic wall during flexible ureteroscopic surgery.Methods we retrospectively reviewed 17 consecutive cases of parapelvic renal cysts treated by ultrasound-guided flexible ureteroscopy between march 2017 and may 2020.The differences between the simple flexible ureteroscopic technique and ultrasound-guided flexible ureteroscopic technique were compared.The surgical procedures, postoperative complications, results and patient follow-ups were evaluated.Results the cyst wall was seen clearly in 10 patients with ureteroscopic vision.Another 7 patients underwent ultrasound-guided flexible ureteroscopic surgery since it was difficult to identify the cyst wall.The mean operative time was 25.9 ± 8.7 min and 37.1 ± 10.1 min for the conventional and modified techniques, respectively (p = 0.004); the mean time to search for cysts was 17.6 ± 5.8 min and 26.5 ± 8.4 min, respectively (p = 0.002); and the mean incision time was 7.1 ± 4.9 min and 12.1 ± 5.6 min, respectively (p = 0.000).All of the patients were followed-up for 12 months, and no serious complications or recurrence were observed.Conclusions we demonstrated that it is feasible and safe to treat parapelvic renal cysts by ultrasound-guided flexible ureteroscopic incision and drainage.The small sample size and need for further studies were the limitations of our work.

Journal: BMC urology (2022)
Publication types: Journal Article
Isolation, Synthesis and Absolute Configuration of the Pericharaxins A and B, Epimeric Hydroxy-Polyene Glycerol Ethers from the Calcarean SpongePericharax heteroraphis.

Naturally occurring epimeric hydroxy-polyene glycerol ether pericharaxins a (1a) and b (1b) were isolated from the calcarean sponge pericharax heteroraphis.The structural and stereochemical characterization of both diastereoisomers were established on the basis of spectroscopic data analysis and total synthesis in seven steps.The mixture of pericharaxins a (1a) and b (1b) was proven to be epimeric by chiral-phase hplc analysis of both synthetic and natural samples.Further separation of the epimers and application of mosher's method to the synthetic compounds allowed unequivocal absolute configuration assignment.While natural products and the synthetic intermediates were shown to be non-cytotoxic on the hct116 cell line, the endochondral differentiation activity using human type x collagen transcription activity in atdc5 cells is interesting.

Journal: Marine drugs (2022)
Publication types: Journal Article
Role of Ingested Amino Acids and Protein in the Promotion of Resistance Exercise-Induced Muscle Protein Anabolism.

The goal of this critical review is to comprehensively assess the evidence for the molecular, physiologic, and phenotypic skeletal muscle responses to resistance exercise (re) combined with the nutritional intervention of protein and/or amino acid (aa) ingestion in young adults.We gathered the literature regarding the translational response in human skeletal muscle to acute exposure to re and protein/aa supplements and the literature describing the phenotypic skeletal muscle adaptation to re and nutritional interventions.Supplementation of protein/aas with re exhibited clear protein dose-dependent effects on translational regulation (protein synthesis) through mammalian target of rapamycin complex 1 (m torc1) signaling, which was most apparent through increases in p70 ribosomal protein s6 kinase 1 (s6k1) phosphorylation, compared with postexercise recovery in the fasted or carbohydrate-fed state.These acute findings were critically tested via long-term exposure to re training (ret) and protein/aa supplementation, and it was determined that a diminishing protein/aa supplement effect occurs over a prolonged exposure stimulus after exercise training.Furthermore, we found that protein/aa supplements, combined with ret, produced a positive, albeit minor, effect on the promotion of lean mass growth (when assessed in >20 participants/treatment); a negligible effect on muscle mass; and a negligible to no additional effect on strength.A potential concern we discovered was that the majority of the exercise training studies were underpowered in their ability to discern effects of protein/aa supplementation.Regardless, even when using optimal methodology and large sample sizes, it is clear that the effect size for protein/aa supplementation is low and likely limited to a subset of individuals because the individual variability is high.With regard to nutritional intakes, total protein intake per day, rather than protein timing or quality, appears to be more of a factor on this effect during long-term exercise interventions.There were no differences in strength or mass/muscle mass on ret outcomes between protein types when a leucine threshold (>2 g/dose) was reached.Future research with larger sample sizes and more homogeneity in design is necessary to understand the underlying adaptations and to better evaluate the individual variability in the muscle-adaptive response to protein/aa supplementation during ret.

Journal: The Journal of nutrition (2016)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, U.S. Gov't, Non-P.H.S.;Review
Population-Based Preference Weights for the EQ-5D Health States Using the Visual Analogue Scale (VAS) in Iran.

Health-related quality of life (hrqo l) is used as a measure to valuate healthcare interventions and guide policy making.The euro qol eq-5d is a widely used generic preference-based instrument to measure health-related quality of life.Objectives the objective of this study was to develop a value set of the eq-5d health states for an iranian population.Patients and methods this study is a cross-sectional study of iranian populations.Our sample from iranian populations consists out of 869 participants, who were selected for this study using a stratified probability sampling method.The sample was taken from individuals living in the city of tehran and was stratified by age and gender from july to november 2013.Respondents valued 13 health states using the visual analogue scale (vas) of the eq-5d.Several fixed effects regression models were tested to predict the full set of health states.We selected the final model based on the logical consistency of the estimates, the sign and magnitude of the regression coefficients, goodness of fit, and parsimony.We also compared predicted values with a value set from similar studies in the uk and other countries.Results our results show that the hrqo l does not vary among socioeconomic groups.Models at the individual level resulted in an additive model with all coefficients being statistically significant, r(2) = 0.55, a value of 0.75 for the best health state (11112), and a value of -0.074 for the worst health state (33333).The value set obtained for the study sample remarkably differs from those elicited in developed countries.Conclusions this study is the first estimate for the eq-5d value set based on the vas in iran.Given the importance of locally adapted value set the use of this value set can be recommended for future studies in iran and in the emro regions.

Journal: Iranian Red Crescent medical journal (2016)
Publication types: Journal Article
A new species ofHelionothripsfrom China (Thysanoptera, Panchaetothripinae).

Helionothrips lushanensissp.N.is described from china.The new species is characterised by the head entirely dark brown, antennal segments i-viii almost uniformly yellowish brown and iii-iv strongly vasiform, metascutellum without produced posterior margins, and male has no pore plate on the abdominal sternites.

Journal: ZooKeys (2017)
Publication types: Journal Article
Development of an Atomic-Oxygen-Erosion-Resistant, Alumina-Fiber-Reinforced, Fluorinated Polybenzoxazine Composite for Low-Earth Orbital Applications.

An atomic-oxygen-erosion-resistant fluorinated benzoxazine resin and composite were developed.The benzoxazine resin, abbreviated as “baf-oda-fu,” consists of four benzoxazine rings, and was synthesized from bisphenol af (baf), 4,4′-oxydianiline (oda), furfurylamine (fu), and paraformaldehyde.The resin was characterized by infrared spectroscopy (ft-ir), proton nuclear magnetic resonance spectroscopy (1h nmr), differential scanning calorimetry (dsc), and thermogravimetric analysis (tga).An analysis of the solvent-washed product showed a technical grade purity (>95%) and a yield of approximately 85%.Subsequent polymerization of the resin was successfully performed by heating step-wise and opening the benzoxazine rings to form a crosslinked network.Thermal analyses showed a melting temperature of 115 °c and polymerization temperature of 238 °c, both being characteristic values of benzoxazine monomers.The benzoxazine resin was also blended with polyoctahedral sisesquoxane (poss) and reinforced with alumina fibers.The tg of the resin, as determined by dma of the composite, could reach as high as 308 °c when post-curing and the poss additive were utilized.The low-earth orbit atomic-oxygen erosion rate was simulated by an rf plasma asher/etcher.The atomic-oxygen resistance of poly(baf-oda-fu) fell along an established trend line based on its fluorine content.

Journal: Polymers (2022)
Publication types: Journal Article
Quiet Time During Postpartum Hospitalization Can Improve Rest, Bonding, and Breastfeeding.

Childbearing families spend only a brief period of time in the hospital after birth.During their stay, women and newborns must adjust to the life-altering circumstances that accompany becoming part of a new family unit.Parents must also be open to receiving a wide range of health education while distracted and exhausted.The reality of inpatient hospitalization is that it is often an environment full of unwelcome sensory stimulation.Interruptions from visitors and hospital staff may also infringe on privacy or alone time.The care provided is not always sensitive to a family's needs.Initial research on quiet time initiatives during the postpartum hospitalization have shown promising results for supporting rest, bonding, and breastfeeding and improving patient satisfaction scores.

Journal: Nursing for women's health (2020)
Publication types: Journal Article
Praziquantel Reduces Maternal Mortality and Offspring Morbidity by Enhancing Anti-Helminthic Immune Responses.

Alongside the wide distribution throughout sub saharan africa of schistosomiasis, the morbidity associated with this chronic parasitic disease in endemic regions is often coupled with infection-driven immunomodulatory processes which modify inflammatory responses.Early life parasite exposure is theorized to drive immune tolerance towards cognate infection as well as bystander immune responses, beginning within uteroexposure to maternal infection.Considering that 40 million women of childbearing-age are at risk of infection worldwide, treatment with praziquantel during pregnancy as currently recommended by who could have significant impact on disease outcomes in these populations.Here, we describe the effects of anthelminthic treatment on parasite-induced changes to fetomaternal cross talk in a murine model of maternal schistosomiasis.Praziquantel administration immediately prior to mating lead to clear re-awakening of maternal anti-parasite immune responses, with persistent maternal immune activation that included enhanced anti-schistosome cytokine responses.Clearance of parasites also improved capacity of dams to endure the additional pressure of pregnancy during infection.Maternal treatment also drove lasting functional alterations to immune system development of exposed offspring.Prenatal anthelminthic treatment skewed offspring immune responses towards parasite clearance and reduced morbidity during cognate infection.Maternal treatment also restored offspring protective ig e antibody responses directed against schistosome antigens, which were otherwise suppressed following exposure to untreated maternal infection.This was further associated with enhanced anti-schistosome cytokine responses from treatment-exposed offspring during infection.In the absence of cognate infection, exposed offspring further demonstrated imprinting across cellular populations.We provide further evidence that maternal treatment can restore a more normalized immune profile to such offspring exposedin uteroto parasite infection, particularly in b cell populations, which may underlie improved responsiveness to cognate infection, and support the who recommendation of anthelminthic treatment during pregnancy.

Journal: Frontiers in immunology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Thyroidectomy with energy-based devices: surgical outcomes and complications-comparison between Harmonic Focus, LigaSure Small Jaw and Thunderbeat Open Fine Jaw.

Being the thyroid gland a highly vascularized organ, achieving a meticulous hemostasis is essential to avoid serious complications.Currently, energy-based devices are widely used in thyroid surgery.The aim of this study was to compare harmonic focus (hf), liga sure small jaw (lsj) and thunderbeat open fine jaw (tb) in terms of surgical outcomes and complications.Methods patients undergoing thyroidectomy in our unit between january 2012 and june 2018 were retrospectively analyzed.According to the type of energy-device used, patients were divided into three groups: group a (hf), group b (lsj) and group c (tb).Results a total of 1,165 patients were included in this study: 1,012 in group a, 96 in group b and 57 in group c.Demographic data and histopathological findings were comparable between the three groups.About the postoperative stay and complications, no statistically significant difference was found.The mean operative time was 89.41±20.60 minutes in group a, 85.57±15.91 minutes in group b and 78.07±17.67 minutes in group c (p<0.01).However, the post-hoc test for all pairwise comparisons showed a statistically significant difference only between group a and group c.Conclusions hf, lsj and tb have proved to be safe and effective.The postoperative stay and complications were comparable between the three groups.Considering the limits of our investigation, further studies are needed to investigate the effect of tb on operative times.

Journal: Gland surgery (2020)
Publication types: Journal Article
Systematic Review and Individual Patient Data Analysis of Uncommon Variants of Glioblastoma: An Analysis of 196 Cases.

S different variant of gbm has been reported viz.Epithelioid glioblastoma (gbm-e), rhabdoid gbm (gbm-r), small cell gbm (gbm-sc), giant cell gbm (gbm-gc), gbm with neuro ectodermal differentiation (gbm-pnet) with unknown behavior.Materials we conducted a systematic review and individual patient data analysis of these rare gbm variants.We searched pub med, google search, and cochrane library for eligible studies till july 1st2016 published in english language and collected data regarding age, sex, subtype and treatment received, progression free survival (pfs), overall survival (os).Statistical package for social sciences (spss) v16 software was used for all statistical analysis.Results we retrieved data of 196 patients with rare gbm subtypes.Among these gbm-gc is commonest (51%), followed by gbm-r (19%), gbm-pnet (13%), gbm-sc (9%) and gbm-e (8%).Median age at diagnosis was 38, 40, 43.5, 69.5 and 18 years, respectively.Male: female ratio was 2:1 for gbm-e, and 1:3 for gbm-sc.Maximal safe resection followed by adjuvant local radiation was used for most of the patients.However, 6 patients with gbm-pnet, 3 each of gbm-e, gbm-sc received adjuvant craniospinal radiation.Out of 88 patients who received chemotherapy, 64 received temozolomide alone or combination chemotherapy containing temozolomide.Median pfs and os for the entire cohort were 9 and 16 months.In univariate analysis, patient with a gross total resection had significantly better pfs and os compared to those with a sub total resection [23 vs.13 months (p-0.01)].Median os for gbm pnet, gbm-gc, gbm-sc, gbm-r and gbm-e were 32, 18.3, 11, 12 and 7.7 months, respectively (p = 0.001).Interestingly, 31.3%, 37.8% of patients with gbm-e, gbm-r had csf dissemination.Conclusion overall cohort of rarer gbm variant has equivalent survival compared to gbm not otherwise specified.However, epithelioid and rhabdoid gbm has worst survival and one third shows csf dissemination.

Journal: Neurology India (2022)
Publication types: Systematic Review;Journal Article
In an Absolute State: Elevated Use of Absolutist Words Is a Marker Specific to Anxiety, Depression, and Suicidal Ideation.

Absolutist thinking is considered a cognitive distortion by most cognitive therapies for anxiety and depression.Yet, there is little empirical evidence of its prevalence or specificity.Across three studies, we conducted a text analysis of 63 internet forums (over 6,400 members) using the linguistic inquiry and word count software to examine absolutism at the linguistic level.We predicted and found that anxiety, depression, and suicidal ideation forums contained more absolutist words than control forums (ds > 3.14).Suicidal ideation forums also contained more absolutist words than anxiety and depression forums (ds > 1.71).We show that these differences are more reflective of absolutist thinking than psychological distress.It is interesting that absolutist words tracked the severity of affective disorder forums more faithfully than negative emotion words.Finally, we found elevated levels of absolutist words in depression recovery forums.This suggests that absolutist thinking may be a vulnerability factor.

Journal: Clinical psychological science : a journal of the Association for Psychological Science (2018)
Publication types: Journal Article
Lipomatosis of axillary lymph nodes in a cynomolgus monkey (Macaca fascicularis).

Lipomatosis of lymph nodes is defined as the replacement of the lymphatic parenchyma by adipose tissue which grows in the node from the hilus toward the cortical zone.In humans, it is considered as part of the normal aging process and is common in obese patients, but there are no reports in non-human primates.In this report, we describe the first case of lymph node lipomatosis in the bilateral axillary lymph nodes of a young adult cynomolgus monkey.Macroscopically, there were no apparent abnormalities in the axillary lymph nodes on either side, and their volumes were unchanged.At the cut surface, pale yellow fat-like tissue was observed in the medullary area.Histopathologically, well differentiated adipocytes replaced a large part of the lymphatic parenchyma in the area from the hilus to the medulla without any malignant findings.Based on these findings, the patient was diagnosed with lipomatosis of the lymph nodes.

Journal: Journal of toxicologic pathology (2022)
Publication types: Case Reports;Journal Article
Metallosupramolecular polymers as precursors for platinum nanocomposites.

Nanocomposites comprising a polymer matrix and metallic nanoparticles (nps) can merge the structural features of the matrix material with the functional characteristics of the nps.While such materials are promising for a wide range of applications, their preparation typically requires multi-step processes that can be difficult to control.Alternatively, materials with nps can be directly accessed in a controlled manner by exploiting zero-valent metallosupramolecular polymer (msp) precursors.We here report how the nature of the polymer and its molecular weight affect the nanocomposite formation and structure.Poly(tetrahydrofuran)-based macromonomers with suitable ligands are used to prepare msps based on bis(η2-alkyne)platinum(0) complexes.Heating these materials causes disassembly of the complexes and, upon the release of pt0-atoms, pt-nps form in the matrix polymer.The pt content in the msp influences the np formation and thereby the characteristics of the nanocomposites.It is also possible to trigger the complex dissociation and np formation by exposure to uv light.This allows photolithographic processing and thus the preparation of nanocomposites that contain pt-nps in a spatially controlled manner.

Journal: Polymer chemistry (2022)
Publication types: Journal Article