syedzayyan/paper_mill_benchmark huggingface dataset:
Review on Sublethal Effects of Environmental Contaminants in Honey Bees (Apis mellifera), Knowledge Gaps and Future Perspectives.

Honey bees and the pollination services they provide are fundamental for agriculture and biodiversity.Agrochemical products and other classes of contaminants, such as trace elements and polycyclic aromatic hydrocarbons, contribute to the general decline of bees' populations.For this reason, effects, and particularly sublethal effects of contaminants need to be investigated.We conducted a review of the existing literature regarding the type of effects evaluated in apis mellifera, collecting information about regions, methodological approaches, the type of contaminants, and honey bees' life stages.Europe and north america are the regions in which a.Melliferabiological responses were mostly studied and the most investigated compounds are insecticides.a.Melliferawas studied more in the laboratory than in field conditions.Through the observation of the different responses examined, we found that there were several knowledge gaps that should be addressed, particularly within enzymatic and molecular responses, such as those regarding the immune system and genotoxicity.The importance of developing an integrated approach that combines responses at different levels, from molecular to organism and population, needs to be highlighted in order to evaluate the impact of anthropogenic contamination on this pollinator species.

Journal: International journal of environmental research and public health (2021)
Publication types: Journal Article;Review
Late Diagnosis of Bilateral Choanal Atresia: A Case Report of a Nine-Year-Old Girl.

Bilateral choanal atresia is a surgical emergency because of the risk of neonate death from acute asphyxia if treatment is delayed.Its diagnostic confirmation is often endoscopic or ct scan and requires a search for associated malformations.We present the case of a nine-year-old girl who was referred to the ent department with suspected adenoid pathology.Her medical history showed respiratory distress at birth treated as a neonatal infection.We suspected bilateral choanal atresia due to the absence of fogging on mirror test and failure to pass a 6fr or 8fr suction catheter through the nasal cavity into the nasopharynx.Facial ct confirmed the presence of bilateral mixed osteo-membranous choanal atresia.Transpalatal choanoplasty was successfully performed with pre and postoperative endoscopic examination.This clinical case adds to the limited literature on bilateral choanal atresia diagnosed long after birth, raising once again the lack of knowledge of choanal atresia by some health workers, emergency neonatal care, the mechanism of breathing in the newborn, and the management of this malformation.Transpalatal choanoplasty is a good alternative when technical conditions do not allow an endoscopic endonasal approach.

Journal: Cureus (2022)
Publication types: Case Reports;Journal Article
Autologous Versus Alloplastic Reconstruction for Patients with Obesity: A Systematic Review and Meta-analysis.

Autologous flaps may have superior outcomes when compared to implant breast reconstruction in patients with obesity.To date, no published review has illustrated the superiority of autologous to implant-based reconstruction in this study group in terms of aesthetics outcomes and surgical complications.Methods a systematic search was conducted on pub med, cochrane, google scholar, and embase from inception to december 31, 2020.Studies comparing the outcomes (patient satisfaction and complications) of autologous versus implant-based reconstruction in patients with bmi > 30 were selected.Results the search yielded 1633 articles, of which 76 were assessed in full text.A total of 12 articles fit inclusion for qualitative review; of them, 7 were meta-analyzed.Autologous reconstruction had a lower incidence of infection (or 0.74 [95% ci 0.59, 0.92]), hematoma/seroma formation (or 0.34 [95% ci 0.23, 0.49]), and reconstructive failure (or 0.47 [95% ci 0.36, 0.62]), but not skin necrosis (or 0.95 [95% ci 0.73, 1.25]) or wound dehiscence (or 1.03 [95% ci 0.72, 1.49]) when compared to implant-based reconstruction.Deep vein thrombosis (dvt) and pulmonary embolism occurred more frequently with autologous versus alloplastic reconstruction (or 2.21 [95% ci 1.09, 4.49] for dvt and or 2.49 [95% ci 1.13, 5.48] for pe).Breastq scores were higher for the autologous breast reconstruction when compared to implant-based group, but failed to reach significance (p value >0.05).Conclusion the current evidence in the literature suggests that autologous breast reconstruction has lower surgical complication rate when compared to implant-based reconstruction at the expense of higher risk of thrombotic complications for patients with bmi > 30.Level of evidence iii this journal requires that authors assign a level of evidence to each article.For a full description of these evidence-based medicine ratings, please refer to the table of contents or the online instructions to authors www.springer.com/00266 .

Journal: Aesthetic plastic surgery (2022)
Publication types: Journal Article;Meta-Analysis;Review;Systematic Review
Efficacy and safety of vedolizumab in Crohn's disease in patients from Asian countries in the GEMINI 2 study.

The efficacy and safety of vedolizumab in moderate-to-severely active crohn's disease (cd) were demonstrated in the gemini 2 study (nct00783692).This post-hoc exploratory analysis aimed to assess the efficacy and safety of vedolizumab in the subgroup of patients from asian countries.Methods during the induction phase (doses at day 1, 15), clinical remission, enhanced clinical response, and change in c-reactive protein at 6 weeks; during the maintenance phase, clinical remission, enhanced clinical response, glucocorticoid-free remission and durable clinical remission at 52 weeks, were the efficacy outcomes of interest.Efficacy and safety of vedolizumab compared to placebo were assessed in asian countries (hong kong, india, malaysia, singapore, south korea, and taiwan) using descriptive analyses.Results during the induction phase, in asian countries (n = 51), 14.7% of the vedolizumab-treated patients achieved clinical remission at week 6 compared to none with placebo (difference, 14.7%; 95% confidence interval, 15.8%-43.5%).In non-asian countries (n = 317), the remission rate at week 6 with vedolizumab was 14.5%.During maintenance, in asian countries, clinical remission rates at 52 weeks with vedolizumab administered every 4 weeks, vedolizumab administered every 8 weeks and placebo were 41.7%, 36.4%, and 0%, respectively; while enhanced clinical response rates were 41.7%, 63.6%, and 42.9%, respectively.During induction, 39.7% of patients with vedolizumab experienced an adverse event compared to 58.8% of patients with placebo, and vedolizumab was generally well-tolerated.Conclusions this post-hoc analysis demonstrates the treatment effect and safety of vedolizumab in moderateto-severely active cd in patients from asian countries.

Journal: Intestinal research (2021)
Publication types: Journal Article
Intelligent tuberculosis activity assessment system based on an ensemble of neural networks.

This article proposes a novel approach to assess the degree of activity of pulmonary tuberculosis by active tuberculoma foci.It includes the development of a new method for processing lung ct images using an ensemble of deep convolutional neural networks using such special algorithms: an optimized algorithm for preliminary segmentation and selection of informative scans, a new algorithm for refining segmented masks to improve the final accuracy, an efficient fuzzy inference system for more weighted activity assessment.The approach also includes the use of medical classification of disease activity based on densitometric measures of tuberculomas.The selection and markup of the training sample images were performed manually by qualified pulmonologists from a base of approximately 9,000 ct lung scans of patients who had been enrolled in the dispensary for 15 years.The first basic step of the proposed approach is the developed algorithm for preprocessing ct lung scans.It consists in segmentation of intrapulmonary regions, which contain vessels, bronchi, lung walls to detect complex cases of ingrown tuberculomas.To minimize computational cost, the proposed approach includes a new method for selecting informative lung scans, i.e., those that potentially contain tuberculomas.The main processing step is binary segmentation of tuberculomas, which is proposed to be performed optimally by a certain ensemble of neural networks.Optimization of the ensemble size and its composition is achieved by using an algorithm for calculating individual contributions.A modification of this algorithm using new effective heuristic metrics has been proposed which improves the performance of the algorithm for this problem.A special algorithm was developed for post-processing of tuberculoma masks obtained during the segmentation step.The goal of this step is to refine the calculated mask for the physical placement of the tuberculoma.The algorithm consists in cleaning the mask from noisy formations on the scan, as well as expanding the mask area to maximize the capture of the tuberculoma location area.A simplified fuzzy inference system was developed to provide a more accurate final calculation of the degree of disease activity, which reflects data from current medical studies.The accuracy of the system was also tested on a test sample of independent patients, showing more than 96% correct calculations of disease activity, confirming the effectiveness and feasibility of introducing the system into clinical practice.

Journal: Computers in biology and medicine (2022)
Publication types: Journal Article
Pipeline embolization of proximal middle cerebral artery aneurysms: A multicenter cohort study.

And purpose flow diversion of aneurysms located in the m1 segment and middle cerebral artery bifurcation with pipeline embolization device is sometimes performed, but further study is needed to support its regular use in aneurysm treatment.Here, we report measures of safety and efficacy for pipeline embolization in the proximal middle cerebral artery in a multi-center cohort.Materials and methods clinical and angiographic data of eligible patients were retrospectively obtained from participating centers and assessed for key clinical and angiographic outcomes.Additional details were extracted for patients with complications.Results in our multi-center cohort, complete aneurysm occlusion was achieved in 71% (17/24) of treated aneurysms.There were no deaths or disabling strokes, but non-disabling ischemic strokes occurred in 8% (2/24) of patients.For aneurysms in the m1 segment, complete aneurysm occlusion was observed in 75% (12/16) of aneurysms, aneurysm volume reduction was observed in 100% (16/16) of aneurysms, and non-disabling ischemic strokes occurred in 13% (2/16) of patients.For aneurysms at the middle cerebral artery bifurcation, complete aneurysm occlusion was observed in 63% (5/8) of aneurysms, aneurysm volume reduction occurred in 88% (7/8) of aneurysms, and ischemic or hemorrhagic complications occurred in 0% (0/8) of patients.Conclusion pipeline embolization of cerebral aneurysms in the m1 segment and middle cerebral artery bifurcation demonstrated a 71% rate of complete aneurysm occlusion.There were no deaths or disabling strokes, but there was an 8% rate of non-disabling ischemic strokes.

Journal: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences (2022)
Publication types: Journal Article;Multicenter Study
A novel TCN2 mutation with unusual clinical manifestations of hemolytic crisis and unexplained metabolic acidosis: expanding the genotype and phenotype of transcobalamin II deficiency.

Transcobalamin deficiency is a rare inborn metabolic disorder, characterized by pancytopenia, megaloblastic anemia, failure to thrive, diarrhea, and psychomotor retardation.Case presentation we describe a patient who first presented at 3 months of age, with pancytopenia, hepatosplenomegaly, recurrent infection, metabolic acidosis, and acute hemolytic crisis.Extensive hematologic and immunologic investigations did not identify inherited bone marrow failure syndrome, acute leukemia or its related disorders.Whole exome sequencing identified a novel homozygous tcn2 mutation, c.428-2a > g and m rna study confirmed an aberrant transcription of exon 4 skipping.The mutant protein is predicted to have an in-fame 51 amino acids deletion (np_000346:p.gly143_val193del).The patient exhibited marked clinical improvement following hydroxocobalamin treatment.Conclusions transcobalamin deficiency should be investigated in infants with unexplained pancytopenia and acute hemolytic crisis with or without typical evidence of vitamin b12 deficiency.

Journal: BMC pediatrics (2022)
Publication types: Case Reports;Journal Article;Research Support, Non-U.S. Gov't
Deep learning in magnetic resonance image reconstruction.

Magnetic resonance (mr) imaging visualises soft tissue contrast in exquisite detail without harmful ionising radiation.In this work, we provide a state-of-the-art review on the use of deep learning in mr image reconstruction from different image acquisition types involving compressed sensing techniques, parallel image acquisition and multi-contrast imaging.Publications with deep learning-based image reconstruction for mr imaging were identified from the literature (pub med and google scholar), and a comprehensive description of each of the works was provided.A detailed comparison that highlights the differences, the data used and the performance of each of these works were also made.A discussion of the potential use cases for each of these methods is provided.The sparse image reconstruction methods were found to be most popular in using deep learning for improved performance, accelerating acquisitions by around 4-8 times.Multi-contrast image reconstruction methods rely on at least one pre-acquired image, but can achieve 16-fold, and even up to 32- to 50-fold acceleration depending on the set-up.Parallel imaging provides frameworks to be integrated in many of these methods for additional speed-up potential.The successful use of compressed sensing techniques and multi-contrast imaging with deep learning and parallel acquisition methods could yield significant mr acquisition speed-ups within clinical routines in the near future.

Journal: Journal of medical imaging and radiation oncology (2021)
Publication types: Journal Article;Review
On the Spatiotemporal Characteristics of Class-Discriminating Functional Networks.

We target the problem of identifying brain's functional networks that are discriminatory across classes of tasks, using data obtained through electroencephalography (eeg).A three-step framework is presented.First, the eeg data is segmented to identify the intervals during which cortical functional networks remain quasi-stationary.Second, these functional networks are spatially localized in the cortex.Finally, by employing the proposed discriminative boolean matrix factorization (dbmf) algorithm, functional networks that are most recurrent in one class of tasks, but are least recurrent in the other are identified.The dbmf algorithm is capable of providing the spatial maps of the discriminative functional networks as well as information about their dynamic occurrence over time.The framework is applied to experimental eeg data, recorded during a motor task.The results show that the proposed framework identifies several parietal/motor functional networks as being the most discriminatory for motor execution trials from non-execution trials.

Journal: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference (2018)
Publication types: Journal Article
Mental health issues in parents of children with autism spectrum disorder: A multi-time-point study related to COVID-19 pandemic.

Given the unpredictability and challenges brought about by the 2019 novel coronavirus (covid-19) pandemic, this study aimed to investigate the impact trend of the prolonged pandemic on the mental health of parents of children with autism spectrum disorder (asd).The 8112 participants included parents of children with asd and parents of typically developing (td) children at two sites (heilongjiang and fujian province, china).The parents completed a set of self-report questionnaires covering demographic characteristics, influences related to covid-19, covid-19 concerns and perceived behaviors, as well as the connor-davidson resilience scale (cd-risc), self-rating anxiety scale (sas), and self-rating depression scale (sds) by means of an online survey platform.Data were collected by three cross-sectional surveys carried out in april 2020 (time 1), october 2020 (time 2), and october 2021 (time 3).The results of quantitative and qualitative comparisons showed that: (i) parents of children with asd had lower levels of resilience, and more symptoms of anxiety and depression than parents of td children at each time point (all p < 0.05); and (ii) there were significant time-cumulative changes in resilience, anxiety, and depression among all participants (all p < 0.05).The logistic regression analyzes after adjusting for demographic characteristics revealed that the following factors were significantly associated with poor resilience and a higher rate of anxiety and depression in parents of children with asd: time-point, the effect of covid-19 on children's emotions and parents' emotions, changes in relationships, changes in physical exercise, changes in daily diet during the covid-19 pandemic, and covid-19-related psychological distress.In conclusions, the parents did not report improvements in resilience, anxiety, or depression symptoms from time 1 to time 2 or 3, indicating that cumulative mental health issues increased when, surprisingly, the covid-19 restrictions were eased.The psychological harm resulting from the covid-19 pandemic is far-reaching, especially among parents of children with asd.

Journal: Autism research : official journal of the International Society for Autism Research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Joint measurability in nonequilibrium quantum thermodynamics.

In this letter we investigate the concept of quantum work and its measurability from the viewpoint of quantum measurement theory.Very often, quantum work and fluctuation theorems are discussed in the framework of projective two-point measurement (tpm) schemes.According to a well-known no-go theorem, there is no work observable which satisfies both (i) an average work condition and (ii) the tpm statistics for diagonal input states.Such projective measurements represent a restrictive class among all possible measurements.It is desirable, both from a theoretical and experimental point of view, to extend the scheme to the general case including suitably designed unsharp measurements.This shifts the focus to the question of what information about work and its fluctuations one is able to extract from such generalized measurements.We show that the no-go theorem no longer holds if the observables in a tpm scheme are jointly measurable for any intermediate unitary evolution.We explicitly construct a model with unsharp energy measurements and derive bounds for the visibility that ensure joint measurability.In such an unsharp scenario a single work measurement apparatus can be constructed that allows us to determine the correct average work and to obtain free energy differences with the help of a jarzynski equality.

Journal: Physical review. E (2022)
Publication types: Journal Article
Pulmonary manifestations of immune dysregulation in CTLA-4 haploinsufficiency and LRBA deficiency.

The primary immunodeficiency syndromes of cytotoxic t lymphocyte-associated protein 4 (ctla-4) haploinsufficiency and lipopolysaccharide-responsive and beige-like anchor protein (lrba) deficiency present with multisystem immune dysregulation.The aim of this study was to characterize and compare the pulmonary manifestations of these two diseases.Methods we retrospectively analyzed the pulmonary clinical, radiologic, and histopathologic characteristics of six patients with ctla-4 haploinsufficiency and four patients with lrba deficiency with pulmonary involvement followed at a large tertiary care center.Results chronic respiratory symptoms were more frequent in patients with lrba deficiency versus ctla-4 haploinsufficiency (3/4 vs.1/6).Cough was the most common respiratory symptom.Abnormalities in pulmonary exam and pulmonary function testing were more frequent in lrba deficiency (4/4, 2/4) compared to ctla-4 haploinsufficiency (1/6, 2/6).Chest computed tomography (ct) findings included mediastinal lymphadenopathy (4/4 in lrba deficiency vs.1/4 in ctla-4 haploinsufficiency), pulmonary nodules (4/4, 3/4), ground-glass opacification (4/4, 3/4), and bronchiectasis (3/4, 1/4).Lymphocytic inflammation, concentrated bronchovasculocentrically and paraseptally, was the predominant pathologic finding and was observed in all patients who had lung biopsies (n = 3 with lrba deficiency; n = 3 with ctla-4 haploinsufficiency).Conclusion despite phenotypic overlap amongst these diseases, lrba deficiency demonstrated greater severity of pulmonary disease, indicated by respiratory symptoms, pulmonary exam, and intrathoracic radiologic findings.Chest ct was the most sensitive indicator of pulmonary involvement in both disorders.Lymphocytic inflammation is the key histologic feature of both disorders.Pediatric pulmonologists should consider these disorders of immune dysregulation in the relevant clinical context to provide earlier diagnosis, comprehensive pulmonary evaluation and treatment.

Journal: Pediatric pulmonology (2021)
Publication types: Journal Article
Emotion-related impulsivity: Testing a model of arousal effects on cognitive control.

The trait-based tendency to respond rashly to emotions is robustly tied to many forms of psychopathology and poor behavioural outcomes, including aggression and suicidality.Researchers have found associations between response inhibition and emotion-related impulsivity; however, effect sizes are often small.Because emotion-related impulsivity emerges in the context of heightened positive and negative emotions, arousal is a candidate trigger of impulsivity.The goals of the present study were to (1) replicate the association between emotion-related impulsivity and response inhibition, and (2) test whether emotion-related impulsivity is associated with arousal-induced decays in response inhibition performance.Participants (n= 55) completed a self-report measure of emotion-related impulsivity, and then completed a computer-based response inhibition task (the antisaccade task, in which participants must make a rapid saccadic eye movement away from a cue rather than toward it) before and after a well-validated stress induction (the trier social stress test).Psychophysiological indices of arousal were measured throughout the session.Findings provide partial support for the association between emotion-related impulsivity and pre-stress response inhibition.Contrary to hypotheses, emotion-related impulsivity did not interact with arousal to predict post-stress response inhibition performance after controlling for pre-stress response inhibition performance.Future research is needed to consider clinical samples and to assess whether emotion-related impulsivity is related to deficits in other facets of cognitive control and decision-making.

Journal: Brain and neuroscience advances (2022)
Publication types: Journal Article