syedzayyan/paper_mill_benchmark huggingface dataset:
Bioinspired morphing wings: mechanical design and wind tunnel experiments.

Bioinspired morphing wings are part of a novel research direction offering greatly increased adaptability for use in unmanned aerial vehicles.Recent models published in the literature often rely on simplifications of the bird wing apparatus and fail to preserve many of the macroscopic morphological features.Therefore, a more holistic design approach could uncover further benefits of truly bioinspired bird wing models.With this issue in mind, a prototype inspired by crow wings (corvusgenus) is developed, which is capable of planform wing morphing.The prototype imitates the feather structure of real birds and replicates the folding motion with a carbon fiber reinforced polymer skeleton with one controllable degree of freedom.The mechanism supplies a smooth airfoil lifting surface through a continuous morphing motion between a fully extended and a folded state.When extended, it has an elliptic planform and emarginated slots between primary remiges.In the folded state, the wingspan is reduced by 50% with a 40% reduction in surface area and the aspect ratio decreases from 2.9 to 1.2.Experimental data from a subsonic wind tunnel investigation is presented for flow velocities ranging from 5 to 20 m s-1, corresponding to reynolds numbers between 0.7 × 105-2.8 × 105.The wing is analyzed in the three static states (folded, intermediate, and extended) through aerodynamic coefficients and flow visualizations along the surface.The bioinspired design enables the wing to capture several phenomena found on real bird wings.Through its morphing capabilities and intrinsic softness, the wing can sustain large angles of attack with greatly delayed stall and maintain optimal performance at different velocities.

Journal: Bioinspiration & biomimetics (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Lithiophilic Zn Sites in Porous CuZn Alloy Induced Uniform Li Nucleation and Dendrite-free Li Metal Deposition.

Three-dimensional (3d) lithiophilic host is one of the most effective ways to regulate the li dendrites and volume change in working li metal anode.The state-of-the-art 3d lithiophilic hosts are facing one main challenge in that the lithiophilic layer would melt or fall off in high-temperature environment when using the thermal infusion method.Herein, a 3d porous cu zn alloy host containing anchored lithiophilic zn sites is employed to prestore li using the thermal infusion strategy, and a 3d composite li is thus fabricated.Benefiting from the lithiophilic zn sites with a strong adsorption capacity with li, which is based on the analyses of the nucleation overpotential, binding energy calculation, and the operando optical observation of li plating/stripping behaviors, facile uniform li nucleation and dendrite-free li deposition could be achieved in the interior of the 3d porous cu zn alloy host and the 3d composite li shows remarkable enhancement in electrochemical performance.

Journal: Nano letters (2020)
Publication types: Journal Article
An impaired learning environment: Resident physicians' experience of the transition to pandemic care during the first wave of the COVID-19 pandemic in Sweden.

Introduction extensive studies regarding the covid-19 pandemic have shown negative effects on physicians-in-training.Besides a high workload, their learning environment has been affected.A quality learning environment is vital for residents' physician's clinical development and also their health.Nevertheless, few studies have explored this.The aim of this study was to explore resident physicians' experiences of transition to pandemic care during the first wave of the covid-19 pandemic in sweden.Method in this qualitative study, 12 swedish resident physicians were interviewed using a semi-structured interview guide.They were interviewed between june and october of 2020 and asked to reflect on the pandemic and, more specifically, the first wave.The empirical material was analysed using qualitative content analysis.The analysis resulted in one theme and four categories.Results the theme identified was an impaired learning environmentwhich signifies the disruptions the resident physicians experienced during the first wave of the pandemic.The four categories, professional role insecurity, high expectations but little influence, stagnant clinical development, and professional growth through experience, describe in what way the learning environment was impacted.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article
G-CSF-producing left lung squamous cell carcinoma positive for ROS1 rearrangements completely resected after neoadjuvant radiation chemotherapy: A case report.

Granulocyte colony-stimulating factor (g-csf) promotes neutrophil production.G-csf-producing tumors have a feature of neutrophilia without infection, and most patients with g-csf-producing tumors show an aggressive clinical course and poor prognosis.A 71-year-old woman was diagnosed with left lung cancer, c t4n1m0, stage iiia.Severe neutrophilia and bone marrow uptake in 18-fluorodeoxyglucose-positron emission tomography suggested the possibility of g-csf-producing lung cancer.Following neoadjuvant radiation chemotherapy, left lower lobectomy and left upper lobe partial resection were performed.According to pathology findings of the resected specimen, the patient was diagnosed with g-csf-producing left lung squamous cell carcinoma.Moreover, genetic tests showed that the tumor cells were positive for c-ros oncogene 1 (ros1) rearrangements.To our knowledge, this is the first reported case of g-csf-producing lung cancer with ros1 rearrangements, and complete resection was performed successfully after neoadjuvant radiation chemotherapy.

Journal: Respiratory medicine case reports (2022)
Publication types: Case Reports;Journal Article
A computational analysis of the effect of supporting organs on predicted vesical pressure in stress urinary incontinence.

Stress urinary incontinence (sui) or urine leakage from urethra occurs due to an increase in abdominal pressure resulting from stress like a cough or jumping height.Sui is more frequent among post-menopausal women.In the absence of bladder contraction, vesical pressure exceeds urethral pressure leading to urine leakage.The main aim of this study is to utilize fluid-structure interaction techniques to model bladder and urethra computationally under an external pressure like sneezing.Both models have been developed with linear elastic properties for the bladder wall while the patient model has also been simulated utilizing the mooney-rivlin solid model.The results show a good agreement between the clinical data and the predicted values of the computational models, specifically the pressure at the center of the bladder.There is 1.3% difference between the predicted vesical pressure and the vesical pressure obtained from urodynamic tests.It can be concluded that the accuracy of the predicted pressure in the center of the bladder is significantly higher for the simulation assuming nonlinear material property (hyperelastic) for the bladder in comparison to the accuracy of the linear elastic model.The model is beneficial for exploring treatment solutions for sui disorder.Graphical abstract3d processing of bladder deformation during abdominal pressure of a the physiological model and b the pathological model (starting from left to right and up to down, consecutively).

Journal: Medical & biological engineering & computing (2020)
Publication types: Journal Article
Free ISG15 and Protein ISGylation Emerging in SARS-CoV-2 Infection.

Interferon-simulated gene 15 (isg15) belongs to the family of ubiquitin-like proteins.Isg15 acts as a cytokine and modifies proteins through isgylation.This posttranslational modification has been associated with antiviral and immune response pathways.In addition, it is known that the genome of severe acute respiratory syndrome coronavirus 2 (sars-co v-2) encodes proteases critical for viral replication.Consequently, these proteases are also central in the progression of coronavirus disease 2019 (covid-19).Interestingly, the protease sars-co v-2-plpro removes isg15 from isgylated proteins such as irf3 and mda5, affecting immune and antiviral defense from the host.Here, the implications of isg15, isgylation, and generation of sars-co v-2-plpro inhibitors in sars-co v-2 infection are discussed.

Journal: Current drug targets (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Machine learning evaluates changes in functional connectivity under a prolonged cognitive load.

One must be aware of the black-box problem by applying machine learning models to analyze high-dimensional neuroimaging data.It is due to a lack of understanding of the internal algorithms or the input features upon which most models make decisions despite outstanding performance in classification, pattern recognition, and prediction.Here, we approach the fundamentally high-dimensional problem of classifying cognitive brain states based on functional connectivity by selecting and interpreting the most relevant input features.Specifically, we consider the alterations in the cortical synchrony under a prolonged cognitive load.Our study highlights the advances of this machine learning method in building a robust classification model and percept-related prestimulus connectivity changes over the conventional trial-averaged statistical analysis.

Journal: Chaos (Woodbury, N.Y.) (2021)
Publication types: Journal Article
Association of obstructive sleep apnea with hypertension: A systematic review and meta-analysis.

Obstructive sleep apnea (osa) is a sleep disorder characterized as complete or partial upper airflow cessation during sleep.Although it has been widely accepted that osa is a risk factor for the development of hypertension, the studies focusing on this topic revealed inconsistent results.We aimed to clarify the association between osa and hypertension, including essential and medication-resistant hypertension.Methods the preferred reporting items for systematic reviews and meta-analyses (prisma) was followed.Pub med and embase databases were used for searching the relevant studies published up to december 31, 2016.A quantitative approach of meta-analysis was performed to estimate the pooled odds ratio (or) and 95% confidence interval (ci).Results twenty-six studies with 51 623 participants (28 314 men, 23 309 women; mean age 51.8 years) met inclusion criteria and were included in this study.Among them, six studies showed a significant association between osa and resistant hypertension (pooled or = 2.842, 95% ci = 1.703-3.980,p< 0.05).Meanwhile, the combination of 20 original studies on the association of osa with essential hypertension also presented significant results with the pooled ors of 1.184 (95% ci = 1.093-1.274,p< 0.05) for mild osa, 1.316 (95% ci = 1.197-1.433,p< 0.05) for moderate osa and 1.561 (95% ci = 1.287-1.835,p< 0.05) for severe osa.Conclusions our findings indicated that osa is related to an increased risk of resistant hypertension.Mild, moderate and severe osa are associated essential hypertension, as well a dose-response manner relationship is manifested.The associations are relatively stronger among caucasians and male osa patients.

Journal: Journal of global health (2018)
Publication types: Journal Article;Meta-Analysis;Review;Systematic Review
Anti-adiposity and lipid-lowering effects of schisandrol A in diet-induced obese mice.

Lignan schisandrol a (sol a) is known to have antioxidant and anti-inflammatory effects.However, the impact of sol a on obesity is poorly understood.To test the hypothesis that sol a has anti-obesity effects, c57bl/6j mice were fed a high-fat diet with or without sol a (0.006%, w/w) for 16 weeks.Sol a decreased visceral fat mass (10%) by increasing energy expenditure and upregulating white adipose tissue thermogenic genes m rna expression.Furthermore, sol a upregulated adipose lpl m rna expression and decreased plasma free fatty acid (ffa), triglyceride (tg), apolipoprotein (apo) b, aspartate aminotransferase levels and tg/hdl-cholesterol and apo b/apo a1 ratios as well as hepatic lipid droplets.Increased hepatic β-oxidation and fecal ffa and tg levels were observed in the sol a-supplemented mice, suggesting an association of its lipid-lowering effect with increased hepatic β-oxidation, fecal fat excretion and adipose lpl.Conclusionally, this study provides evidence on the protective effects of sol a against adiposity, dyslipidemia and nonalcoholic fatty liver disease in obese mice.

Journal: Journal of food biochemistry (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Vibrational non-Boltzmann effects on the dissociation rate of oxygen.

Both the internal energy nonequilibrium and the nb effects of the vibrational state distribution influence the calculation of the dissociation rate coefficient.The state-to-state (sts) method gives the exact dissociation rate coefficients under the influence of two nonequilibrium effects, while the single group linear maximum-entropy (sglm) model only considers the internal energy nonequilibrium effects.Therefore, the ratioζof the dissociation rate coefficient calculated by the sts method and the sglm model is used in this paper to describe the nb effects on the dissociation rate coefficient.The zero-dimensional (0d) heating adiabatic thermochemical nonequilibrium process of oxygen was simulated by the sts method with a post-surge temperature of 7000-11 000 k.The variation regularity of the nb effects in the relaxation process were investigated usingζ, and it was found that the nb effects were mainly affected by temperature.And then the relaxation process after the normal shock with the same post-surge temperature of 7000-11 000 k was simulated.The nb effects in the two non-equilibrium processes were compared, and it was found that although there is a conversion between internal energy and fluid kinetic energy in the latter, the nb effects in both processes have similar change rules with similar temperature change rules.If the specific internal energy is the same, the nb effects in both processes are also quantitatively consistent.This finding provides a basis for the improvement of the nonequilibrium model considering the nb effects.

Journal: Physical chemistry chemical physics : PCCP (2023)
Publication types: Journal Article
Ultrasound stimulation improves inflammatory resolution, neuroprotection, and functional recovery after spinal cord injury.

Spinal cord injury (sci) is associated with limited functional recovery.Despite advances in neuroscience, realistic therapeutic treatments for sci remain unavailable.In this study, the effects of non-invasive ultrasound (us) treatment on behavior and inflammatory responses were evaluated in a rat model of sci.Adult female sprague-dawley rats were subjected to spinal cord contusion injury.Two different us parameters (sciu5: 5% and sciu40: 40% duty cycle) were applied, and their effects on behavioral recovery after sci were quantified.Tissue and neuronal responses were detected.Immunofluorescence was used to detect inflammatory markers.In the rat model of sci, motor function was more effectively restored, and the lesion cavity area was smaller in the sciu5 group.Furthermore, the sciu5 protocol elicited an anti-inflammatory response at the injury site by reducing degenerative fjc-labeled neurons, macrophage/microglia activation, and infiltration.Thus, the lesion area decreased, and tissue density increased.Meanwhile, the sciu40 protocol did not improve motor function or induce an anti-inflammatory response at the injury site.The sciu5 protocol effectively accelerated the rate of improved exercise performance in the rat model while reducing inflammation.Accordingly, appropriate us stimulation may represent a promising treatment modality for sci with beneficial anti-inflammatory effects.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
On the propagation of waves in the atmosphere.

The leading-order equations governing the unsteady dynamics of large-scale atmospheric motions are derived,viaa systematic asymptotic approach based on the thin-shell approximation applied to the ellipsoidal model of the earth's geoid.We present some solutions of this single set of equations that capture properties of specific atmospheric flows, using field data to choose models for the heat sources that drive the motion.In particular, we describe standing-waves solutions, waves propagating towards the equator, equatorially trapped waves and we discuss the african easterly jet/waves.This work aims to show the benefits of a systematic analysis based on the governing equations of fluid dynamics.

Journal: Proceedings. Mathematical, physical, and engineering sciences (2021)
Publication types: Journal Article
Evaluation of endoscopic gastrojejunostomy revision after Roux-en-Y gastric bypass for treatment of dumping syndrome.

And aims gastrojejunostomy stomal dilation is a frequent cause of weight regain after roux-en-y gastric bypass and may be a contributing cause of dumping syndrome.This study aims to evaluate the long-term durability of endoscopic gastrojejunostomy revision (egjr) to resolve dumping syndrome.Methods a retrospective chart review was performed of patients undergoing egjr at a single institution from january 1, 2013 to december 1, 2018.The primary endpoint, dumping symptom resolution, was measured at 1 month and at the most recent postoperative follow-up.Continuous data are reported as mean and standard deviations and categorical data as percentages.The fisher exact test was used to assess associations between categorical variables.Results ninety-eight patients underwent egjr for dumping syndrome.Mean patient age was 51 years (standard deviation [sd], 9.9), and mean body mass index (bmi) was 36.2 kg/m2(sd, 7.1), with most patients (53%) presenting with bmis ≥35 kg/m2.Thirty-two patients (32%) reported severe dumping (≥3 symptoms).All patients were followed-up for 1 month, and 83% had a long-term follow-up at a mean of 3.45 years (sd, 1.7) after egjr.In addition, 88% had initial symptom resolution at 1 month, and 85% reported symptom resolution 3 years postoperatively.Patients with gerd had a statistically significant improvement in dumping syndrome at 3 years compared with those without gerd (69% vs 62%, p = .03).Long-term weight loss averaged 2.1 pounds after egjr.Conclusions egjr is associated with effective and durable resolution of dumping syndrome at 3 years postoperatively, with a minimal long-term impact on weight loss.The presence of gerd preoperatively correlates with a statistically significant resolution of dumping syndrome.

Journal: Gastrointestinal endoscopy (2022)
Publication types: Journal Article
Identification of bioactive compounds, morphology, and nutritional composition of bacupari (Garcinia brasiliensis (Mart)) pulp powder in two stages of maturation - A short communication.

In view of the low exploitation garcinia brasiliensis and its richness in bioactive compounds, this article is justified by the need to develop a product which adds value to this fruit.The objective was to develop bacupari pulp powder (bpp) in two stages of maturation and to evaluate its physicochemical, microstructural and bioactive properties.Data showed that bpp can be considered as a source of fiber (≅16 g.100-1/ p 6 g.100-1.Regarding the antioxidant content, it was found that the abts method showed the best result (2449 μmol te/100 g/p > 0.05) and it was the first time that the bioactive compounds folic acid, trans-ferulic acid, and sinapic acid were identified in this fruit.Therefore, the use of the bpp form is an alternative for the consumption of this underexploited fruit.

Journal: Food chemistry (2022)
Publication types: Journal Article
Differentiation of Human Induced Pluripotent Stem Cell into Macrophages.

As a model to interrogate human macrophage biology, macrophages differentiated from human induced pluripotent stem cells (hi pscs) transcend other existing models by circumventing the variability seen in human monocyte-derived macrophages, whilst epitomizing macrophage phenotypic and functional characteristics over those offered by macrophage-like cell lines ( mukherjeeet al., 2018 ).Furthermore, hi pscs are amenable to genetic manipulation, unlike human monocyte-derived macrophages (mdms) (van wilgenburget al., 2013 ; lopez- yrigoyenet al., 2020 ), proposing boundless opportunities for specific disease modelling.We outline an effective and efficient protocol that delivers a continual production of hi psc-derived-macrophages (i macs), exhibiting human macrophage surface and intracellular markers, together with functional activity.The protocol describes the resuscitation, culture, and differentiation of hi psc into mature terminal macrophages, via the initial and intermediate steps of expansion of hi pscs, formation into embryoid bodies (ebs), and generation of hematopoietic myeloid precursors.We offer a simplified, scalable, and adaptable technique that advances upon other protocols, utilizing feeder-free conditions and reduced growth factors, to produce high yields of consistent i macs over a period of several months, economically.

Journal: Bio-protocol (2022)
Publication types: Journal Article
Nanocarriers responsive to a hypoxia gradient facilitate enhanced tumor penetration and improved anti-tumor efficacy.

Because of their abnormal vasculature and the dense tumor extra-cellular matrix, solid tumors prevent the deep and uniform penetration of nanocarriers.Numerous studies have shown that nanocarriers with a positively charged surface exhibit enhanced tumor penetration.Therefore, a hypoxia responsive nanocarrier [responsive micelles (rms)] was developed, which can gradually increase the positive surface charge by responding to hypoxia gradients, and eventually achieve deep penetration in tumors.The nanocarrier was composed of a poly(caprolactone) core and a mixed shell of poly(ethylene glycol) (peg) and 4-nitrobenzyl chloroformate (nbcf)-modified polylysine (pll).During the blood circulation, the nbcf-modified pll was shielded by the peg, which gave it the ability to inhibit its rapid removal by the immune system.After reaching the tumor, the hypoxia microenvironment triggered partial nbcf degradation that recovered the amine groups of pll, leading to a remarkable change in the surface to a positively charged one that enabled the penetration of the nanocarrier into the tumor.As the nanocarrier penetrated into the interior of the tumor, the decrease in oxygen concentration led to the further degradation of the nbcf-modified pll, resulting in the increase of the positive surface charge which further facilitated the deep penetration.The subsequent in vitro and in vivo experiments certified that rm/doxorubicin had a better penetration ability and improved inhibition efficacy on tumor tissues, which demonstrated its potential application in cancer therapy.

Journal: Biomaterials science (2019)
Publication types: Journal Article