syedzayyan/paper_mill_benchmark huggingface dataset:
Colostomy Delays Cell Loss in the Brain and Improves Juvenile Survival in a Neonatal Rat Model of Hirschsprung’s Disease

Hirschsprung’s disease is a congenital malformation characterized by the absence of enteric ganglia in the distal intestine and gut obstruction.Our previous study indicates the brain pathology during the disease progression.A subpopulation of hirschsprung’s disease patients is also associated with anomalies of the central nervous system.In the investigation, we studied a rat model of hirschsprung’s disease, known as spotting lethal (sl/sl) etb-/- rats, which carries a spontaneous deletion in endothelin receptor b (human gene name: ednrb) and manifests a similar phenotype as humans with hirschsprung’s disease.Homozygous mutant sl/sl rats were successfully rescued from premature death by performing colostomy and dramatically survived to their juvenile age.By the body weight measured, their body growth was not revealed to be significantly different between etb-/- and wildtype etb+/+ or heterozygous (+/sl) etb+/- groups while all underwent the same colostomy.Cell loss was investigated in several brain regions by using terminal deoxynucleotidyl transferase-mediated d utp nick end-labeling assay (tunel) in etb+/+, etb-/-, and etb+/- rats.Number of tunel-positive cells in the cerebellum and the hippocampus of etb-/- rats was significantly increased compared with that of the etb+/+ and etb+/- rats.Tunel-positive cells were observed in the molecular layer and granular cell layers of the cerebellum.In contrast, no significant difference in the density of tunel-positive cells was revealed in the cerebral cortex.These results suggest that either endothelin receptor b sl mutation or colostomy has predominant lasting effects on the cell survival/loss in the cerebellum and hippocampus of adult etb-/- rats.Our findings provide the information on cellular changes in the brains of patients with hirschsprung’s disease due to congenital ednrb mutation as well as clinically relevant interventions.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Clinical Significance and Correlation Decomposition of Cord Blood NO, Activin A Levels, and MCA/UA with Fetal Distress

The clinical significance and correlation of cord blood no, activin a levels, and middle cerebral artery (mca)/umbilical artery (ua) with fetal distress are explored.120 puerperae who delivered in the obstetrics department of our hospital from january 2021 to january 2022 are selected as the examination subjects.According to the diagnostic criteria of fetal distress, they are divided into 70 cases of fetal distress and 50 cases of normal delivery.The parameters of umbilical cord blood no, activin a, ua, and mca are contrast between the two sets, then the diagnostic value of umbilical cord blood no and activin a combined with ua and mca in fetal distress is analyzed.The experimental results show cord blood no and activin a combined with ua and mca have a high diagnostic value for fetal distress, and there is an extensive correlation with the occurrence of fetal distress, which provides a reliable clinical diagnosis of fetal distress in a timely manner.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Clinical Observation on the Effect of Systematic Nursing Intervention on Cognitive Function, Life Activity Ability, and Quality of Life of Senile Dementia Patients

To explore the influence of systematic nursing intervention on the life ability and quality of senile dementia patients.Methods.Total of 82 senile dementia patients who were admitted to our hospital from january 2018 to january 2020 were divided into two groups according to the random number table, and the nursing intervention was analyzed.41 patients in the control group were given routine nursing care, and 41 patients in the observation group were given systematic nursing intervention.Patients were assessed cognitively using the montreal cognitive assessment scale (mo ca).The barthel index and sf-36 were used to evaluate the patients’ daily activity function and quality of life.A symptom checklist-90-revised (scl-90-r) was used to assess mental distress.The social-adaptive function rating scale (safe) and social skills inventory (ssc) were used to evaluate the patients’ social interaction ability before and after nursing intervention.Nursing satisfaction was distributed to patients in the form of a self-prepared nursing satisfaction questionnaire for scoring.Results.After the nursing intervention, the mo ca scores of patients in the two groups were higher than those before the nursing intervention, and the scores in the observation group were higher than those in the control group p &lt; 0.05 .After the nursing intervention, the barthel index scores of patients in the two groups were higher than those before the nursing intervention, and the scores in the observation group were higher than those in the control group p &lt; 0.05 .After the nursing intervention, the sf-36 scores of patients in the two groups were higher than those before the nursing intervention, and the scores in the observation group were higher than those in the control group p &lt; 0.05 .After nursing intervention, the scl-90-r scores of patients in the two groups were lower than those before nursing intervention, and the scores in the observation group were lower than those in the control group p &lt; 0.05 .After the nursing intervention, the safe scores of patients in the two groups were lower than those before the nursing intervention, and the safe scores of the observation group were lower than those of the control group p &lt; 0.05 .After the nursing intervention, the ssc scores of patients in the two groups were lower than those before the nursing intervention, and the scores in the observation group were lower than those in the control group p &lt; 0.05 .After nursing intervention, the total satisfaction degree of the control group (80.49%) was lower than that of the observation group (97.56%) p &lt; 0.05 .Conclusion.The implementation of systematic nursing intervention is conducive to improve the cognitive function, activity of life, and quality of life of senile dementia patients who have a positive effect, and nursing satisfaction is higher.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Clinical Study;
Clinical Observation and Pharmacoeconomic Evaluations of Original Research Drug and Generic Drug Bortezomib in the Treatment of Multiple Myeloma

Multiple myeloma (mm) is one of the hitherto incurable malignant blood tumors.Bortezomib plays an important role in the treatment of mm.Objective.We aimed to compare effectiveness, safety, and pharmacoeconomic evaluations of the original research drug and the generic drug bortezomib in the treatment of mm, so as to provide a reasonable basis for the selection of drugs in clinical diagnosis and treatment.Methods.A collection of 374 patients with mm were diagnosed and treated with combined bortezomib in our hospital from july 2019 to january 2020.two hundred and sixty nine cases met the criteria for inclusion and discharge.According to the different drug manufacturers, divided into the original research drug group (n = 149) and the generic drug group (n = 120).The effectiveness and safety were separately counted, and use the cost-minimization analysis to make the pharmacoeconomic evaluations.Results.Compared with the results of the two groups, there was no statistical difference between the two groups of treatment efficacy or adverse reaction rates ( p &gt; 0.05).The average daily cost of the original research drug group was 2954.38 chinese yuan (cny), the average treatment cost per cycle was 32967.69 cny, the average daily cost of the generic drug group was 2697.29 cny, and the average treatment cost per cycle was 29129.57 cny.The price of the generic drug group is lower than the original drug group, and there was a statistical difference between the two groups ( p &lt; 0.05).Conclusion.There was no difference between the two groups of effectiveness or safety, and the generic drug is more economical in the treatment.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Clinical Study;
Clinical Efficacy of Retroauricular Injection of Methylprednisolone Sodium Succinate in the Treatment of Sudden Deafness with Type 2 Diabetes

The etiology of sudden deafness is still unclear.In recent years, people’s life rhythm is getting faster and faster.Fatigue, environment, diet, psychology, and other factors have increased the morbidity rate of sudden deafness and improved the quality of life of patients.And work efficiency is greatly affected.Aims.A study to investigate the clinical efficacy of postauricular injection of methylprednisolone sodium succinate in the treatment of sudden deafness with type 2 diabetes.Materials and methods.Sixty patients with sudden deafness who were treated in our hospital from january 2018 to october 2020 were selected as the subjects of this prospective study and divided into 30 cases each in the comparison group and the observation group according to the random number remainder grouping method.The comparison group was treated conventionally, and the observation group was treated with postauricular injection of methylprednisolone sodium succinate on the basis of the comparison group.Patients in the two groups were observed and compared on the 3rd, 6th, and 9th days after treatment with pure-tone hearing threshold checks and regular monitoring of blood glucose, blood rheology, and other indexes.Results.On the 7th, 14th, and 30th days after treatment, the pure-tone audiometric thresholds of the two groups were gradually decreased, and the changes in the pure-tone audiometric thresholds in the observation group were greater than those in the control group.After lunch on the 6th day and after lunch on the 9th day, it was lower than that in the control group, and the difference was statistically significant ( p &lt; 0.05 ).30 days after treatment, the blood viscosity, fibrin, and platelet aggregation rate of the observation group were significantly lower than those of the control group.After treatment, the clinical efficacy rate of the observation group was 96%, which was significantly higher than that of the control group, 80%, and the above differences were statistically significant ( p &lt; 0.05 ).Conclusion.Treatment with postauricular injection of methylprednisolone sodium succinate has shown better therapeutic recovery in patients with sudden deafness, improved pure-tone hearing threshold, reduced risk of blood glucose elevation, and improved clinical outcomes for patients with sudden deafness, providing some reference for the treatment of patients with sudden deafness.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Clinical Efficacy of Immunoglobulin Combined with Glucocorticoids in the Treatment of Oculomotor Myasthenia Gravis in Children and the Effect on Serum Immunity

To investigate the effects of treatment with immunoglobulin on clinical outcomes and immune function in children with oculomotor myasthenia gravis.The clinical data of 100 pediatric patients with oculomotor myasthenia gravis treated in our hospital from january 2019 to december 2021 were selected as the subjects of this retrospective study and divided into a comparison group and a treatment group according to the different treatment methods.The comparison group was treated with glucocorticoids, and the treatment group was treated with immunoglobulin on the basis of the comparison group.The differences in the serum indexes, the effects of immune function, and the clinical efficacy of the two groups were observed and compared.It was found the comparison of immunoglobulin g (ig g), immunoglobulin a (ig a), and immunoglobulin m (ig m) after treatment was significantly different and lower in the treatment group than in the comparison group; the comparison of cd4+, cd3+, cd4+/cd8+, and nk cells after treatment was significantly different and higher in the treatment group than in the comparison group.The effective rate of 98.00% in the treatment group was significantly higher than that of 76.00% in the comparison group, and the difference was statistically significant.The clinical efficacy of the two groups showed that the fever, cough, sputum, myasthenia gravis crisis, and gastrointestinal reactions in the treatment group were significantly lower than those in the comparison group.The study indicates that comparative study of children with oculomotor myasthenia gravis treated with immunoglobulin combined with glucocorticoids is more effective, effectively improving the immune level of patients and reducing adverse reactions.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Clinical Effect of Open Reduction and Internal Fixation for Femoral Neck Fracture in Young Adults and Related Factors of Femoral Head Necrosis

The purpose of this article is to analyze the clinical effect of open reduction and internal fixation on femoral neck fracture in young adults and to explore the related factors of femoral head necrosis.Methods .The subjects were young and middle‐aged femoral neck fracture patients admitted to our hospital from july 2019 to july 2021.90 patients were randomly divided into two groups according to different treatment methods.The control group ( n = 45) was treated with open reduction and internal fixation with hollow nails, while the observation group ( n = 45) was treated with closed reduction and internal fixation with hollow nails.The clinical effects and adverse reactions of the two groups and the risk factors of avascular necrosis of femoral head were analyzed.Results .Compared with the control group, the operation time of the observation group was significantly shortened ( p &lt; 0.05), the amount of bleeding during the operation was significantly reduced ( p &lt; 0.05), and the incidence of total adverse reactions was significantly reduced ( p &lt; 0.05).The hss score and harris score of the two groups were significantly decreased after treatment ( p &lt; 0.05), but there was no significant difference in the above scores between the two groups before and after treatment ( p &gt; 0.05).The related risk factors of necrosis included gender, garden classification, time from injury to operation, and time of weight bearing after operation ( p &lt; 0.05) but not related to age and cause of injury ( p &gt; 0.05).Conclusion.Open and closed reduction and internal fixation can effectively treat femoral neck fracture in young adults.The risk factors of adverse reactions of osteonecrosis include gender, garden classification, time from injury to operation, and weight‐bearing time after operation.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Clinical Study;
Clinical Care of Hyperthyroidism Using Wearable Medical Devices in a Medical IoT Scenario

This paper presents an in-depth study and analysis of clinical care of patients with hyperthyroidism using wearable medical devices in the context of medical io t scenarios.According to the use scenario of the gateway and the connectivity of the equipment, the hardware architecture, hardware interfaces, functionality, and performance of the gateway were briefly designed, so as to monitor patients with hyperthyroidism more comprehensively and save labor costs.The gateway can provide access to different devices and adaptation functions to different hardware interfaces and provide hardware support for the subsequent deployment of the proposed new medical communication protocols and related information systems.A medical data convergence information system based on multidevice management and multiprotocol parsing was designed and implemented.The system enables the management and configuration of different medical devices and access to data through the targeted parsing of the underlying medical device communication protocols.The system also provides the automatic adaptation of multiple types of underlying medical device communication protocols and automatic parsing of multiple versions and can provide multiple devices to process fused data streams or device information and data from a single device.The use of event-driven asynchronous communication eliminates the tight dependency on service invocation in the synchronous communication approach.The use of a metadata-based data model structure enables model extensions to accommodate the impact of iterative business requirements on the database structure.Real-time patient physiological data transmission for intraoperative monitoring based on the mqtt protocol and video transmission for intraoperative patient monitoring based on the rtmp protocol were implemented.The development of the intelligent medical monitoring service system was completed, and the system was tested, optimized, and deployed.The functionality and performance of the system were tested, the performance issue of slow query speed was optimized, and the deployment of the project using docker containers was automated.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Clinical Application of Remifentanil Combined with Sevoflurane in Manual Reduction of Humeral Supracondylar Fracture in Children

To explore the effect of the combination of remifentanil and sevoflurane on children with humeral supracondylar fractures undergoing manual reduction.Methods.A total of 60 children undergoing manual reduction external fixation due to humeral supracondylar fractures were enrolled between september 2020 and september 2021.According to the random number table method, they were divided into the control group (inhalation of 7% sevoflurane) and the observation group (inhalation of 7% sevoflurane and intravenous infusion of remifentanil).The heart rate (hr), mean arterial pressure (map), and blood oxygen saturation (sp o2) in both groups were investigated.The sedation and analgesic effects, fracture reduction, and complications were compared between the two groups.Results.There was no significant difference found in hr, map, or sp o2 between the two groups at 3 minutes prior to anesthesia, 2 minutes post anesthesia, and post manual reduction ( p &gt; 0.05 ).The difference in hr, map, and sp o2 between the two groups was not statistically significant at any time point ( p &gt; 0.05 ).The good rate of sedation and analgesia in the observation group was 93.33%, which is significantly higher than that in the control group ( p &lt; 0.05 ).The reduction time and success rate of one-time manual reduction in the observation group were higher than those in the control group ( p &lt; 0.05 ).There was no significant difference in fracture healing time between the two groups ( p &gt; 0.05 ).Both groups had airway complications (nausea and vomiting, neurovascular damage and asphyxia, and laryngospasm).Conclusion.The combination of remifentanil and sevoflurane showed good sedative and analgesic effects on children with humeral supracondylar fractures undergoing manual reduction with relatively higher safety.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Design of Counselor Job Matching and Ideological and Political Education Methods Integrating Deep Learning Model

In the process of civic and political education, counselors should not only provide good service guidance for students’ learning but also deeply understand students’ ideological dynamics and psychological conditions.This would help to guide them in establishing healthy ideological concepts and moral qualities.The continuous development of ideological education cannot be achieved without the assistance of an experienced counselor team.There is a nationwide requirement to strengthen the professionalism of college counselors which is presently lagging.There exists a gap between the demand of the job seekers and the relevant products who fail to meet the need of the college administrators, working counselors, and other groups.The present paper focuses on providing solutions to the current problems pertinent to inaccurate matching of counselor positions in ideological and political education, the lagging information feedback, and the existence of imperfect early warning intervention mechanism.The paper proposes an integrated deep learning model which automates the learning of a large number of college students’ user behaviors using deep learning algorithms thereby incorporating early warning classifiers.This helps to establish a model enabling accurate counselor job matching and ideological and political education methods.Simulation is used to verify the effectiveness of the model using relevant databases which establishes the superiority of the proposed method in resolving mismatch issues in human resources, handles imbalances in actual effectiveness, and also ensures lagging information feedback in the process of providing dynamic early warning in case of college and university level ideological and political education.

Journal: Wireless Communications and Mobile Computing (2022)
Publication types: Research Article;
Clinical Analysis of Surgical Treatment of Senile Intertrochanteric Fracture Based on Intelligent Knowledge of Health Care

In order to explore the clinical application value of intelligent health care knowledge combined with closed reduction intramedullary nail fixation in elderly patients with intertrochanteric fracture of the femur, a retrospective analysis is performed on 80 elderly patients who received intertrochanteric surgery from january 2019 to january 2021.All patients were divided into study group and control group based on intelligent medical knowledge received or not.During the phase of treatment, both the two groups were treated with closed reduction and intramedullary nailing.The control group received conventional knowledge training and rehabilitation before and after the surgery, and the research group received additional intelligent medical knowledge health care.Observations of patients after bed and ground time are compared and the vas score is used to evaluate the pain degree at 12 h, 24 h, and 48 h after surgery.Besides, the incidence of postoperative complications in the two groups is observed.From the clinical follow‐up results, it is clearly evident that intramedullary nail fixation based on medical care knowledge can effectively improve the hip function and quality of life in patients, reduce postoperative pain, and improve the prognosis of elderly patients with femoral trochanteric fracture.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;