syedzayyan/paper_mill_benchmark huggingface dataset:
Phytochemical Constituents, Biological Activities, and Health-Promoting Effects of the Melissa officinalis

Medicinal plants are being used worldwide for centuries for their beneficial properties.Some of the most popular medicinal plants belong to the melissa genus, and different health beneficial effects have already been identified for this genus.Among these species, in particular, the melissa officinalis l.Has been reported as having many biological activities, such as antioxidant, antimicrobial, antitumour, antiviral, antiallergic, anti‐inflammatory, and also flatulence inhibiting effects.The beneficial properties of the melissa officinalis , also known as “lemon balm herb”, can be related to the bioactive compounds such as terpenoids, alcohols, rosmarinic acid, and phenolic antioxidants which are present in the plant.In this updated review, the botanical, geographical, nutritional, phytochemical, and traditional medical aspects of m.Officinalis have been considered as well as in vitro and in vivo and clinically proven therapeutic properties have been reviewed with a special focus on health‐promoting effects and possible perspective nutraceutical applications.To evidence the relevance of this plant in the research and completely assess the context, a literature quantitative research analysis has been performed indicating the great interest towards this plant for its beneficial properties.

Journal: Oxidative Medicine and Cellular Longevity (2021)
Publication types: Review Article;
Phytochemical Analysis, Total Phenolic, Flavonoid Contents, and Anticancer Evaluations of Solvent Extracts and Saponins of H. digitata

Cancer is one of the most challenging diseases in the modern era for the researchers and investigators.Extensive research worldwide is underway to find novel therapeutics for prevention and treatment of diseases.The extracted natural sources have shown to be one of the best and effective treatments for cell proliferation and angiogenesis.Different approaches including disc potato model, brine shrimp, and chorioallantoic membrane (cam) assay were adopted to analyze the anticancer effects.Habenaria digitata was also evaluated for mtt activity against nih/3t3 cell line.The dexamethasone, etoposide, and vincristine sulfate were used as a positive control in these assays.All of the extracts including crude extracts (hd.cr), saponin (hd.sp), n‐hexane (hd.hx), chloroform (hd.chf), ethyl acetate (hd.ea), and aqueous fraction (hd.aq) were shown excellent results by using various assays.For example, saponin and chloroform have displayed decent antitumor and angiogenic activity by using potato tumor assay.The saponin fraction and chloroform were shown to be the most efficient in potato tumor experiment, demonstrating 87.5 and 93.7% tumor suppression at concentration of 1000 μ g/ml, respectively, with ic 50 values of 25.5 and 18.3 μ g/ml.Additionally, the two samples, chloroform and saponins, outperformed the rest of the test samples in terms of antiangiogenic activity, with ic 50 28.63 μ g/ml and 16.20 μ g/ml, respectively.In characterizing all solvent fractions, the chloroform (hd.chf) and saponin (hd.sp) appeared to display good effectiveness against tumor and angiogenesis but very minimal activity against a.Tumefaciens .The hd.chf and hd.sp have been prospective candidates in the isolation of natural products with antineoplastic properties.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects

Bergapten (bp) or 5-methoxypsoralen (5-mop) is a furocoumarin compound mainly found in bergamot essential oil but also in other citrus essential oils and grapefruit juice.This compound presents antibacterial, anti-inflammatory, hypolipemic, and anticancer effects and is successfully used as a photosensitizing agent.The present review focuses on the research evidence related to the therapeutic properties of bergapten collected in recent years.Many preclinical and in vitro studies have been evidenced the therapeutic action of bp; however, few clinical trials have been carried out to evaluate its efficacy.These clinical trials with bp are mainly focused on patients suffering from skin disorders such as psoriasis or vitiligo.In these trials, the administration of bp (oral or topical) combined with uv irradiation induces relevant lesion clearance rates.In addition, beneficial effects of bergamot extract were also observed in patients with altered serum lipid profiles and in people with nonalcoholic fatty liver.On the contrary, there are no clinical trials that investigate the possible effects on cancer.Although the bioavailability of bp is lower than that of its 8-methoxypsoralen (8-mop) isomer, it has fewer side effects allowing higher concentrations to be administered.In conclusion, although the use of bp has therapeutic applications on skin disorders as a sensitizing agent and as components of bergamot extract as hypolipemic therapy, more trials are necessary to define the doses and treatment guidelines and its usefulness against other pathologies such as cancer or bacterial infections.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Review Article;
Periodontitis Exacerbates Benign Prostatic Hyperplasia through Regulation of Oxidative Stress and Inflammation

Epidemiological studies demonstrate that men with periodontitis are also susceptible to benign prostatic hyperplasia (bph) and that periodontal treatment can improve the prostatic symptom.However, molecular links of this relationship are largely unknown.The goal of the current study was to elucidate the effects of experimental periodontitis on the hyperplasia of prostate and whether oxidative stress and inflammation participated in this process.For this purpose, ligature‐induced periodontitis, testosterone‐induced bph, and the composite models in rats were established.Four weeks later, all the rats were sacrificed and the following items were measured: alveolar bone loss and histological examination of periodontal tissues were taken to assess the establishment of periodontitis model, prostate index and histological examination of prostate tissues were taken to test the establishment of the bph model, inflammatory cytokines in plasma were assessed, and bax/bcl‐2 proteins related to cell apoptosis were analyzed via western blot analysis.To further investigate whether oxidative stress participates in the aggravation of bph, in vitro models were also conducted to measure the production of intracellular reactive oxygen species (ros) and hydrogen peroxide (h 2 o 2 ) concentration.We found that simultaneous periodontitis and bph synergistically aggravated prostate histological changes, significantly increased ki67 proliferation, and reduced apoptosis in rat prostate tissues.Also, our results showed that periodontal ligation induced increased bcl‐2 protein expression, whereas bax expression was decreased in bph rats than in normal rats.Compared with the control group, periodontitis and bph both significantly enhanced inflammatory cytokine levels of tnf‐ α , il‐6, il‐1 β , and crp.Furthermore, porphyromonas gingivalis lipopolysaccharide induced enhanced generation of intracellular expression of ros and h 2 o 2 in bph‐1 cells.Our experimental evidence demonstrated that periodontitis might promote bph development through regulation of oxidative stress and inflammatory process, thus providing new strategies for prevention and treatment of bph.

Journal: Oxidative Medicine and Cellular Longevity (2021)
Publication types: Research Article;
Peelu (Salvadora oleoides Decne.): An Unexplored Medicinal Fruit with Minerals, Antioxidants, and Phytochemicals

The peelu ( salvadora oleoides decne.) fruit is well known for its nutritional and medicinal values.The current study analyzed the chemical composition of salvadora oleoides fruit.Fresh peelu fruits were harvested, and physicochemical properties, proximate composition, macro‐ and micronutrients, and phytochemical properties were determined.Moreover, ethanol and methanol fruit extract was analyzed for physicochemical properties.The peelu fruit seemed to be a potential source of essential macro‐ ((nitrogen (n), phosphorus (p), potassium (k), calcium (ca), and magnesium (mg)) and micronutrients (zinc (zn), manganese (mn), iron (fe), and copper (cu)).The fruit had significant biochemical properties (total soluble solids (tss), total acidity (ta), and tss : ta ratio) with appreciable moisture, crude fiber, and ash contents.The fruit extracts demonstrated significantly higher antioxidants and phenolics, ascorbic acid contents, and carotenoids.Phytochemical screening of fruit revealed the presence of coumarins, flavonoids, phlobatannins, tannins, and terpenoids.Physicochemical and sensory evaluation of extracts indicated its potential for further in vivo study trials.The peelu fruit was found to be a good source of mineral nutrients, proximate contents, vitamins (ascorbic acid and carotenoid), phytochemicals (total phenolic sand antioxidant contents), and pharmaceutically important metabolites that can be used as functional drink.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Predicting Mental Health of Best Human Capital for Sustainable Organization through Psychological and Personality Health Issues: Shift from Traditional to Novel Machine Learning-Supervised Technique Approach

Researchers in the past discussed the psychological issue like stress, anxiety, depression, phobias on various forms, and cognitive issues (e.g., positive thinking) together with personality traits on traditional research methodologies.These psychological issues vary from one human to other human based on different personality traits.In this paper, we discussed both psychological issues together with personality traits for predicting the best human capital that is mentally healthy and strong.In this research, we replace the traditional methods of research used in the past for judging the mental health of the society, with the latest artificial intelligence techniques to predict these components for attaining the best human capital.In the past, researchers have point out major flaws in predicting psychological issue and addressing a right solution to the human resource working in organizations of the world.In order to give solution to these issues, we used five different psychological issues pertinent to human beings for accurate prediction of human resource personality that effect the overall performance of the employee.In this regard, a sample of 500 data has been collected to train and test on computer through python for selecting the best model that will outperform all the other models.We used supervised ai techniques like support vector machine linear, support vector machine radial basis function, decision tree model, logistic regression, and neural networks.Results proved that psychological issue data from employee of different organizations are better means for predicting the overall performance based on personality traits than using either of them alone.Overall, the novel traditional techniques predicted that sustainable organization is always subject to the control of psychological illness and polishing the personality traits of their human capital.

Journal: BioMed Research International (2022)
Publication types: Research Article;
PD-1 Is an Immune-Inflammatory Potential Biomarker in Cerebrospinal Fluid and Serum of Intractable Epilepsy

Previous studies have demonstrated that immune and inflammatory factors play an important role in recurrent seizures.The pd‐1‐pd‐l pathway plays a central and peripheral immunosuppressive role by regulating multiple signaling pathways during the inflammatory and immunologic processes.This study is aimed at assessing pd‐1 levels in cerebrospinal fluid (csf) and serum samples from patients with intractable epilepsy.Methods .Pd‐1 levels were assessed in csf and serum samples from 67 patients with intractable epilepsy (41 and 26 individuals with partial seizure and intractable status epilepticus, respectively) and 25 healthy controls, using flow cytometric analysis and sandwich enzyme‐linked immunosorbent assays (elisa).Results .Serum‐pd‐1+cd4 + cd25 high treg levels in the experimental groups and the control group were 10.26 ± 2.53 (ps group), 35.95 ± 27.51 (ise group), and 4.69 ± 2.44 (control group).In addition, csf‐pd‐1 level in patients with epilepsy was higher than that in the control group (50.45 ± 29.56 versus 19.37 ± 4.51), indicating a statistically significant difference ( p &lt; 0.05).Interestingly, serum‐ and csf‐pd‐1 levels in individuals with epilepsy were not affected by antiepileptic drug and treatment course, but by epilepsy onset level.Of note, the increase of csf‐ and serum‐pd‐1 levels was more pronounced in subjects with intractable status epilepticus than those with partial seizure.Conclusion .Serum‐ and csf‐pd‐1 levels constitute a potential clinical diagnostic biomarker for intractable epilepsy and could also be used for differential diagnosis.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Pathological, Histological, and Molecular Based Investigations Confirm Novel Mycobacterium bovis Infection in Boselaphus tragocamelus

Mycobacterium bovis ( m.Bovis ) being the main cause of animal tuberculosis is a complex infectious agent and can be a cause of zoonotic tuberculosis zoonosis in public health.To date, the uncommon infection in public health due to m.Bovis still is a great challenge to both veterinary and medical professions and requires a careful diagnosis and confirmation of the bacterium.Therefore, this study for the first time reports the clinical, gross, histopathological, and molecular based confirmation of m.Bovis infection in wildlife animals (nilgai).Prior to death, the morbid animal showed severe pneumonic ailments like moist cough, thick nasal exudates, and dyspnoea.At necropsy, enlargement of mandibular cervical and mesenteric lymph nodes was observed.Different macroscopic lesions such as congestion and hyperaemia, creamy white and catarrhal exudates in trachea, consolidation, grey and red hepatisation of lungs, and micro‐ and macrogranulomatous tubercles containing caseous materials in lungs were observed.The heart of morbid animal showed congestions, myocarditis, and a copious amount of straw‐colored fluid in the pericardial sac.At the microscopic level, lungs indicated granulomatous inflammatory response, presence of multinucleated giant cells, fibrosis, and punctuation of alveoli with chronic inflammatory cells.Histopathological examination of various sections of the heart of the infected animal showed chronic inflammatory response consisting of chronic inflammatory cells like monocyte, lymphocytes, and fibroblasts along with noncalcified eosinophilic materials.At the molecular level, m.Bovis infection was confirmed in various tissues like the heart, lungs, cervical, and mesenteric lymph nodes in morbid animals.In conclusion, based on our results, it can be suggested that more molecular based epidemiological studies are crucial to know the exact cause of pulmonary and cervical tuberculosis in wild animals.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice

Idiopathic pulmonary fibrosis (ipf) is a chronic progressive lung disease characterized by the extensive accumulation of myofibroblasts and collagens.However, the exact mechanism that underlies this condition is unclear.Growing evidence suggests that nadph oxidases (noxs), especially nox4‐derived oxidative stress, play an important role in the development of lung fibrosis.Bleomycin (blm) is a tumor chemotherapeutic agent, which has been widely employed to establish ipf animal models.Osthole (ost) is an active constituent of the fruit of cnidium ninidium .Here, we used an in vivo mouse model and found that ost suppressed blm‐induced body weight loss, lung injury, pulmonary index increase, fibroblast differentiation, and pulmonary fibrosis.Ost also significantly downregulated blm‐induced nox4 expression and oxidative stress in the lungs.In vitro, ost could inhibit tgf‐ β 1‐induced smad3 phosphorylation, differentiation, proliferation, collagen synthesis, nox4 expression, and ros generation in human lung fibroblasts in a concentration‐dependent manner.Moreover, nox4 overexpression could prevent the above effects of ost.We came to the conclusion that ost could significantly attenuate blm‐induced pulmonary fibrosis in mice, via the mechanism that involved downregulating tgf‐ β 1/nox4‐mediated oxidative stress in lung fibroblasts.

Journal: Oxidative Medicine and Cellular Longevity (2021)
Publication types: Research Article;
Natural Products for Neurodegeneration: Regulating Neurotrophic Signals

Neurodegenerative disorders (nds) are heterogeneous groups of ailments typically characterized by progressive damage of the nervous system.Several drugs are used to treat nds but they have only symptomatic benefits with various side effects.Numerous researches have been performed to prove the advantages of phytochemicals for the treatment of nds.Furthermore, phytochemicals such as polyphenols might play a pivotal role in rescue from neurodegeneration due to their various effects as anti‐inflammatory, antioxidative, and antiamyloidogenic agents by controlling apoptotic factors, neurotrophic factors (ntfs), free radical scavenging system, and mitochondrial stress.On the other hand, neurotrophins (nts) including nerve growth factor (ngf), brain‐derived neurotrophic factor (bdnf), nt4/5, and nt3 might have a crucial neuroprotective role, and their diminution triggers the development of the nds.Polyphenols can interfere directly with intracellular signaling molecules to alter brain activity.Several natural products also improve the biosynthesis of endogenous genes encoding antiapoptotic bcl‐2 as well as ntfs such as glial cell and brain‐derived ntfs.Various epidemiological studies have demonstrated that the initiation of these genes could play an essential role in the neuroprotective function of dietary compounds.Hence, targeting nts might represent a promising approach for the management of nds.In this review, we focus on the natural product‐mediated neurotrophic signal‐modulating cascades, which are involved in the neuroprotective effects.

Journal: Oxidative Medicine and Cellular Longevity (2021)
Publication types: Review Article;
Perspectives of Molecular Therapy-Targeted Mitochondrial Fission in Hepatocellular Carcinoma

Current advances of molecular‐targeting therapies for hepatocellular carcinoma (hcc) have improved the overall survival significantly, whereas the results still remain unsatisfied.Recently, much attention has been focused on organelles, such as the mitochondria, to reveal novel strategies to control the cancers.The mitochondria are vital organelles which supply energy and maintain metabolism in most of the eukaryotic cells.They not only execute critical bioenergetic and biosynthetic functions but also regulate ros homeostasis and apoptosis.Existing in a dynamic equilibrium state, mitochondria constantly undergo the fission and fusion processes in normal situation.Increasing evidences have showed that mitochondrial fission is highly related to the diseases and cancers.Distinctive works have proved the significant effects of mitochondrial fission on hcc behaviors and the crosstalks with other molecular pathways.Here, we provide an overview of the mitochondrial fission and the link with hcc, emphasizing on the underlying molecular pathways and several novel materials that modulate hcc behaviors.

Journal: BioMed Research International (2020)
Publication types: Research Article;
Performance Evaluation Method of Online Supply Chain Finance Logistics Enterprises Based on GARCH-VAR

In recent years, china’s core enterprises have been plagued by high operating costs, difficult bank loans, and other practical problems in the supply chain.As a new financing model emerged in recent years, it has opened up new markets in finance and logistics industry and brought new ideas and vitality to all parties in the supply chain.Since the strengthening of supervision, the operation of the industry has gradually changed to the direction of normalization.The study of online loan interest rate fluctuation is helpful to understand the source and characteristics of online loan risk, which has important reference significance for china’s internet lending market.The measurement of interest rate risk can help to monitor market risk in time and improve financial supervision.This paper takes the online loan interest rate under the background of supervision as the research object, combining theoretical analysis and empirical research to explore the characteristics of interest rate fluctuations and the reasons behind the p2p online loan, and discusses the online loan business model.Based on the influencing factors of interest rate fluctuation, this paper analyzes the main characteristics of network loan interest rate from the aspects of interest rate trend interval distribution, regional distribution, and background distribution.This paper adopts the daily closing price data of domestic r insurance company to establish the daily logarithmic return rate series of stock prices.The results show that (1) garch-var model can effectively reflect the stock price fluctuation and market risk degree of the insurance company; (2) the company’s var showed a trend of first rise and then slight decline, with the highest var in 2018; and (3) the interpretation of var value should be combined with financial indicators.The increase in net profit rate will also lead to the decline of var value in the next period.Based on this, countermeasures and suggestions for market risk management are proposed for insurance companies.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Network Pharmacology-Integrated Molecular Docking Reveals the Expected Anticancer Mechanism of Picrorhizae Rhizoma Extract

This study sought to explore the anticancer mechanism of picrorhizae rhizoma (pr) extract based on network pharmacology and molecular docking.The potential chemicals of pr were screened through the traditional chinese medicine systems pharmacology (tcmsp) database and relevant literatures.Corresponding targets of active ingredients were found with the help of the uni prot kb database, and therapeutic targets for cancer action were screened with the help of the gene cards database.We used cytoscape software to construct the compound‐target‐pathway network of pr extract.We utilized the string database to obtain the protein‐protein interaction (ppi) network.We used david database combining gene ontology (go) analysis and kyoto encyclopedia of genes and genomes (kegg) pathway enrichment analysis.Finally, molecular docking was employed for initial efficacy checking.We have identified 16 potential active components of pr through screening, involving 112 disease action targets.Utilizing the gene cards database, 112 intersecting targets between pr extract and cancer were found, which mainly exerts anticancer effects by regulating tumor necrosis factor (tnf), recombinant caspase 3 (casp3), c‐jun nh2‐terminal kinase (jnk)/jun, epidermal growth factor receptor (egfr), and estrogen receptor‐1 (esr1) with some other target genes and pathways associated with cancer.The major anticancer species are prostate cancer, colorectal cancer, small cell lung cancer, etc.In the molecular docking study, herbactin had a strong affinity for tnf.Based on network pharmacology and molecular docking studies, pr and their compounds have demonstrated potential anticancer activities against several key targets.Our preliminary findings provide a strong foundation for further experiments with pr constituents.

Journal: BioMed Research International (2022)
Publication types: Research Article;