syedzayyan/paper_mill_benchmark huggingface dataset:
Quadriceps Recovery After Anterior Cruciate Ligament Reconstruction With Quadriceps Tendon Versus Patellar Tendon Autografts.

Quadriceps tendon (qt) autografts are being increasingly used for anterior cruciate ligament reconstruction (aclr).A paucity of studies exist that compare qt autografts with alternative graft options.Additionally, concerns exist regarding quadriceps recovery after graft harvest insult to the quadriceps muscle-tendon unit.Purpose/hypothesis the purpose of this study was to compare quadriceps recovery and functional outcomes in patients with qt versus bone-patellar tendon-bone (bptb) autografts.The hypothesis was that those with qt autografts would demonstrate superior outcomes.Study design cohort study; level of evidence, 3.Methods active patients with a history of primary, unilateral aclr with soft tissue qt or bptb autografts participated.Quadriceps recovery was quantified using variables of strength, muscle size, and activation.Knee extensor isometric and isokinetic strength was measured bilaterally with an isokinetic dynamometer and normalized to body weight.Quadriceps activation was measured with the superimposed burst technique.The maximal cross-sectional area of each quadriceps muscle was measured bilaterally using magnetic resonance imaging.Assessors of muscle size were blinded to the graft type and side of aclr.Functional tests included hop tests and step length symmetry during walking, measured via spatiotemporal gait analysis.Self-reported function was determined with the international knee documentation committee (ikdc) questionnaire.Neuromuscular and functional outcomes were expressed as limb symmetry indices (lsis: [surgical limb/nonsurgical limb]*100%).Wilcoxon rank-sum tests were used to compare the lsis and ikdc scores between groups.Results there were 30 study participants (19 male, 11 female; median age, 22 years [range, 14-41 years]; median time since surgery, 8 months [range, 6-23 months]), with 15 patients in each group.There were no significant between-group differences in demographic variables or outcomes.Lsis were not significantly different between the qt versus bptb group, respectively: knee extensor isokinetic strength at 60 deg/s (median, 70 [range, 41-120] vs 68 [range, 37-83];p= .285), activation (median, 95 [range, 85-111] vs 92 [range, 82-105];p= .148), cross-sectional area of the vastus medialis (median, 79 [range, 62-104] vs 77 [range, 62-95];p= .425), single-leg hop test (median, 88 [range, 35-114] vs 77 [range, 49-100];p= .156), and step length symmetry (median, 99 [range, 93-104] vs 98 [range, 92-103];p= .653).The median ikdc scores between the qt and bptb groups were also not significantly different: 82 (range, 67-94) versus 83 (range, 54-94); respectively (p= .683).Conclusion patients with qt autografts demonstrated similar short-term quadriceps recovery and postsurgical outcomes compared with patients with bptb autografts.

Journal: Orthopaedic journal of sports medicine (2019)
Publication types: Journal Article
Application of a Computerized Decision Support System to Develop Care Strategies for Elderly Hemodialysis Patients.

In this paper, the strategy of elderly haemodialysis patients' care is analysed by the computer's decision system to conduct an in-depth research machine.Maintenance haemodialysis patients have a high demand for continuation care, and healthcare workers should provide personalized and specialized seamless continuation care services for patients according to patients' needs, by reasonably using the hospital, community, and other health resources and with the help of emerging network technologies, such as information platforms and wearable devices to prolong the survival period of patients and improve their self-management ability and quality of life.The service provision and compensation strategy of the combined healthcare model should be optimized to improve the health protection of the elderly and promote health equity.On the one hand, it should target strengthening the service provision of healthcare integration, guide the elderly to reasonably choose the healthcare integration model, and pay attention to the spiritual and cultural needs and end-of-life care services for the elderly.On the other hand, we should expand the financing channels of medical insurance, optimize the design of compensation mechanisms, explore the role of health risk sharing, and accelerate the development of long-term care insurance, independent of basic medical insurance.The reliability of the scale was found to be 0.916 for the total cronbach alpha coefficient, 0.798-0.919 for each dimension, and 0.813 for the fold-half reliability of the scale; the validity indicated that the correlation coefficient range of each article day with the total scale score was 0.27-0.72, and the correlation coefficient range of each dimension with the total scale was 0.56-0.72.The validation factor analysis was used to verify the structure of the scale.The validation factor analysis indexes met the fitting criteria after correction.The model fitted better with the actual model after correction, indicating that the scale has good reliability.

Journal: Journal of healthcare engineering (2021)
Publication types: Journal Article
Did We Have an Impact? Changes in Racial and Ethnic Composition of Patient Populations Following Implementation of a Pilot Program.

High-quality data are necessary to eliminate health disparities, and are necessary in cancer prevention and control.A pilot project to improve the collection of race and ethnicity data was undertaken.The approach included train-the-trainer and staff training, and racial and ethnic categories were expanded to include "granular ethnicity" or ancestry terms in the patient registration system at five acute care hospitals in rhode island.The self-reported racial and ethnic distribution of the patient population was examined for each pilot hospital.Two of the five pilot hospitals reported significant increases in the identification of hispanic patients.At two other pilot hospitals, the proportion reporting unknown on either race or ethnicity was reduced.Evidence that hispanics struggle to identify with existing racial categories is also highlighted.These results suggest that a modest program of staff training and resources can significantly increase the identification of racial and ethnic minorities, improving the quality of hospital and state cancer registry data.This has many possible benefits, including better alignment with language services for the patient population, better understanding of the healthcare needs of different racial and ethnic groups, and better strategies to not only address disparities, but also assess those efforts.

Journal: Journal for healthcare quality : official publication of the National Association for Healthcare Quality (2017)
Publication types: Journal Article
Corticosterone in American alligator (Alligator mississippiensis) tail scutes: Evaluating the feasibility of using unconventional samples for investigating environmental stressors.

Baseline plasma corticosterone (cort) concentrations have been widely used to investigate the effects of stressors in wild and captive crocodilians.However, collecting baseline plasma cort samples from wild crocodilians may be particularly difficult due to the capture and handling protocols used for large individuals.Thus, it may prove beneficial to use recently modified techniques for extracting cort deposited in keratinized and non-keratinized tissues to better quantify the effects of long-term stress in crocodilians.In this study, we investigated the feasibility of using american alligator (alligator mississippiensis) tail scute tissues to quantify cort by collecting blood and tail scutes from 40 alligators before and after a short-term handling stressor.The objective of the current study was to better understand cort deposition in crocodilian scutes and whether short-term increases in cort could be detected.We found that cort can be reliably extracted from alligator scute tissue and quantified using a commercially available enzyme immunoassay.However, there was a significant increase in scute cort concentrations following an alligator being exposed to a short-term stressor (p = 0.017), although the magnitude of change was less than observed in plasma samples from the same individuals (p = 0.002).Furthermore, our results indicate that there was a significant effect of body condition on an alligator's post-stressor cort concentration (p = 0.02).While our study is among the first to experimentally examine the usefulness of tissue cort in crocodilians, a combination of field and laboratory experiments are needed to better understand deposition rates of cort in scute tissues and to further validate the usefulness of tissue glucocorticoids for evaluating the effects of stress.

Journal: General and comparative endocrinology (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
Switch of serotonergic descending inhibition into facilitation by a spinal chloride imbalance in neuropathic pain.

Descending control from the brain to the spinal cord shapes our pain experience, ranging from powerful analgesia to extreme sensitivity.Increasing evidence from both preclinical and clinical studies points to an imbalance toward descending facilitation as a substrate of pathological pain, but the underlying mechanisms remain unknown.We used an optogenetic approach to manipulate serotonin (5-ht) neurons of the nucleus raphe magnus that project to the dorsal horn of the spinal cord.We found that 5-ht neurons exert an analgesic action in naïve mice that becomes proalgesic in an experimental model of neuropathic pain.We show that spinal kcc2 hypofunction turns this descending inhibitory control into paradoxical facilitation; kcc2 enhancers restored 5-ht-mediated descending inhibition and analgesia.Last, combining selective serotonin reuptake inhibitors (ssris) with a kcc2 enhancer yields effective analgesia against nerve injury-induced pain hypersensitivity.This uncovers a previously unidentified therapeutic path for ssris against neuropathic pain.

Journal: Science advances (2022)
Publication types: Journal Article
Effect of primary tumor location and tumor size on the response to radiotherapy for liver metastases from colorectal cancer.

Metastatic liver tumors (mlts) from colorectal cancer (crc) are often treated with stereotactic body radiation therapy (sbrt).The present study aimed to examine the predictive factors for response of mlts to sbrt.A total of 39 mlts from 24 patients with crc were retrospectively analyzed.Radiotherapy for mlt was typically performed with a prescribed dose equivalent to a biologically effective dose (bed)10of 100 gy.The median follow-up period was 16 months (range, 5-64 months).The median prescribed dose and total bed10were 56 gy (range, 45-72 gy) and 97.5 gy (range, 71.7-115.5 gy), respectively, in a median of 8 fractions (range, 4-33 fractions).The 1- and 2-year local control rates were 67.2 and 35.9%, respectively.For patients with mlt treated with ablative sbrt (bed10≥100 gy in ≤5 fractions), the 1- and 2-year local control rates were 83.3 and 62.5%, respectively.Univariate analysis showed that primary tumor location (left-sided colon), maximum tumor diameter (≤30 mm) and ablative sbrt (bed10≥100 gy in ≤5 fractions) were significantly associated with improved local control (p=0.0058, p=0.0059 and p=0.0268, respectively).Multivariate analysis showed that tumor diameter was significantly associated with improved local control (p=0.0314).In addition, patients who received ablative sbrt had significantly prolonged overall survival times compared with those treated with non-ablative sbrt (p=0.0261).To conclude, tumors ≤30 mm that can be treated with ablative sbrt are associated with good local control rates.The primary tumor location may affect the radiosensitivity of mlts.

Journal: Oncology letters (2017)
Publication types: Journal Article
Mutations in spike protein T cell epitopes of SARS-COV-2 variants: Plausible influence on vaccine efficacy.

With emerging sars-co v-2 variants, vaccines approved so far are under scrutiny for long term effectiveness against the circulating strains.There is a prevalent obsession with humoral immunity as in vitro studies have indicated diminished effects of vaccine-induced neutralizing antibodies.However, this need not clinically translate to vaccine resistance as immune response against all forms of present vaccine preparations is t dependent unlike that against native viral particles which can induce t independent immune responses.Thus, we focused on this major correlate of protection against infections, t cell response.Using bioinformatics tools, we analyzed sars-co v-2 spike protein t cell epitopes and their diversity across delta plus/b.1.617.2.1, gamma/p.1 (variant of concern), b.1.1.429, zeta/p.2 and mink cluster 5/b.1.1.298 variants as well as omicron/b.1.1.529 (variant of concern).We also compared hla restriction profiles of the mutant epitopes with that of the native epitopes (from wuhan_hu_1 strain, used in vaccine formulations).Our observations show ~90% conservation of cd4+ and cd8+ epitopes across delta plus/b.1.617.2.1, gamma/p.1 (variant of concern), b.1.1.429, zeta/p.2 and mink cluster 5/b.1.1.298.For the omicron/b.1.1.529 variant, ~75% of cd4+ and ~ 87% cd8+ epitopes were conserved.Majority of the mutated cd4+ and cd8+ epitopes of this variant were predicted to retain the hla restriction pattern as their native epitopes.The results of our bioinformatics analysis suggest largely conserved t cell responses across the studied variants, ability of t cells to tackle new sars-co v-2 variants and aid in protection from covid-19 post vaccination.In conclusion, the results suggest that current vaccines may not be rendered completely ineffective against new variants.

Journal: Biochimica et biophysica acta. Molecular basis of disease (2022)
Publication types: Journal Article
Optical and electronic properties of silver nanoparticles embedded in cerium oxide.

Wide bandgap oxides can be sensitized to visible light by coupling them with plasmonic nanoparticles (nps).We investigate the optical and electronic properties of composite materials made of ag nps embedded within cerium oxide layers of different thickness.The electronic properties of the materials are investigated by x-ray and ultraviolet photoemission spectroscopy, which demonstrates the occurrence of static charge transfers between the metal and the oxide and its dependence on the np size.Ultraviolet-visible spectrophotometry measurements show that the materials have a strong absorption in the visible range induced by the excitation of localized surface plasmon resonances.The plasmonic absorption band can be modified in shape and intensity by changing the np aspect ratio and density and the thickness of the cerium oxide film.

Journal: The Journal of chemical physics (2020)
Publication types: Journal Article
Saharan air outflow variability in the 1980-2020 period.

Airborne dust represents a hazard to the environment and human health.The outflow of air masses carrying dust from northern africa, the world's largest active dust source, to the north atlantic and mediterranean regions is modulated by atmospheric conditions.However, how global warming-driven changes on atmospheric circulation have influenced north african air outflow in the recent past is not well understood.Here, we explore the saharan air outflow from northwestern africa over the 1980 to 2020 period.We find a decrease in the transport to the atlantic ocean and the iberian peninsula of -0.29 ± 0.16% dec-1and -0.66 ± 0.18% dec-1, respectively, and an increasing trend to the mediterranean sea (0.24 ± 0.18% dec-1) and europe (0.60 ± 0.18% dec-1).The results indicate that the strengthening of the atlantic high pressure system and the saharan thermal low, both associated with the narrowing of the intertropical convergence zone and the hadley cell expansion under global warming, could be favoring the saharan outflow to the mediterranean sea and europe in detriment of transport to the atlantic ocean.The results also show that present-day saharan air arrives at these regions at higher altitudes and in shorter timescales than decades ago.This is associated to the increase in surface heating conditions in the sahara, 0.41 ± 0.02 °c dec-1, that can inject air into windier upper atmospheric levels, thereby allowing higher and faster air transport.Our results suggest a change in the saharan air outflow likely associated with global warming and with potentially significant implications for the temporal and spatial patterns of north african dust export.

Journal: The Science of the total environment (2022)
Publication types: Journal Article
Assessment of cognitive function in young children with type 1 diabetes mellitus using electrophysiological tests.

/objectives diabetes mellitus is a chronic disease that affects many body systems, including the nervous and auditory systems.It is noted that there is a scarcity of research on the effect of diabetes on cognitive functions in particular and auditory functions in general in children with type 1 diabetes.Therefore, this study was designed to assess cognitive and auditory functions in children with type 1 diabetes mellitus and to correlate the reflection of diabetes control on cognitive functions.Methods this study is a case-control study that included 100 children divided into two groups, the patient group, which includes 50 children with type 1 diabetes, and the control group, which consists of 50 healthy children.Subjects in the current study were submitted to pure tone audiometry, speech recognition threshold test, immittancemetry study, and measurement of cortical auditory evoked and p300 potentials (caeps and p300).These audiometric measures were statistically analyzed and correlated with the clinical characteristics of the study group.Results the latency of p300 and caeps was significantly increased while the amplitude of p300 and caeps was significantly decreased in the patient group compared to the control group (p < 0.001).P300 and caeps latency has a positive correlation with hb a1c levels (r = 0.460).In addition, there was significant differences between the two groups regarding the hearing threshold at 8000 hz, and 28% of patients had bilateral sensorineural hearing loss (snhl) at 8 k hz.Conclusion the prolonged p300 and caeps latency and decreased amplitude in patients indicate a cognitive decline in individuals with type 1 diabetes compared to healthy individuals.Hb a1c levels may increase the risk of cognitive impairment in children.In addition, the risk of bilateral snhl increased at 8 k hz in children with type 1 diabetes mellitus.

Journal: Pediatric diabetes (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Histone chaperone HIRA complex regulates retrotransposons in embryonic stem cells.

Histone cell cycle regulator (hira) complex is an important histone chaperone that mediates the deposition of the h3.3 histone variant onto chromatin independently from dna synthesis.However, it is still unknown whether it participates in the expression control of retrotransposons and cell fate determination.Methods we screened the role of hira complex members in repressing the expression of retrotransposons by sh rna depletion in embryonic stem cells (escs) followed by rt-q pcr.Rna-seq was used to study the expression profiles after depletion of individual hira member.Rt-q pcr and western blot were used to determine overexpression of hira complex members.Chromatin immunoprecipitation (ch ip)-q pcr was used to find the binding of h3.3, hira members to chromatin.Co-immunoprecipitation was used to identify the interaction between hira mutant and ubn2.Ch ip-q pcr was used to identify h3.3 deposition change and western blot of chromatin extract was used to validate the epigenetic change.Bioinformatics analysis was applied for the analysis of available ch ip-seq data.Results we revealed that hira, ubn2, and ubn1 were the main repressors of 2-cell marker retrotransposon mervl among hira complex members.Surprisingly, ubn2 and hira targeted different groups of retrotransposons and retrotransposon-derived long noncoding rnas (lnc rnas), despite that they partially shared target genes.Furthermore, ubn2 prevented escs to gain a 2-cell like state or activate trophectodermal genes upon differentiation.Mechanistically, ubn2 and hira suppressed retrotransposons by regulating the deposition of histone h3.3.Decreased h3.3 deposition, that was associated with the loss of ubn2 or hira, caused the reduction of h3k9me2 and h3k9me3, which are known repressive marks of retrotransposons.Conclusions overall, our findings shed light on the distinct roles of hira complex members in controlling retrotransposons and cell fate conversion in escs.

Journal: Stem cell research & therapy (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A pilot intervention combining assessment and feedback with communication training and behavioral nudges to increase HPV vaccine uptake.

Human papillomavirus (hpv) causes >40,000 cancer diagnoses each year, yet vaccination rates remain low because widespread implementation of strategies to increase vaccinations has not occurred.Behavioral nudges have demonstrated efficacy in improving uptake of desired behaviors in health care settings but have not been tested for increasing hpv vaccinations.We assessed the impact of an intervention combining behavioral nudges with other proven strategies (i.e., assessment and feedback, provider communication training) on hpv vaccination rates and parental satisfaction in four midwestern pediatric, outpatient practices.Practices were randomly assigned to receive either assessment and feedback or assessment and feedback combined with vaccine communication training and behavioral nudges in the form of vaccine commitment posters.Providers (n = 16) completed surveys regarding vaccine policies and parents (n = 215) reported on their child's vaccine history and satisfaction with the consultation.Three practices increased hpv vaccination rates (1-10%); however, there was no statistically significant difference by study arm.Most parents (mage 41.3;sd8.1; 85% female, 68% white) indicated their child had previously initiated the hpv vaccine series (61%) and 72% indicated receipt of an hpv vaccine during the study visit.Concerns among hpv vaccine-hesitant parents (28%) included vaccine safety and believing the vaccine is unnecessary (40%).Most parents were satisfied with their consultation.Practices in both intervention groups increased vaccination rates.While some parents continue to harbor concerns about vaccine safety and necessity, parents welcomed discussions about hpv and were satisfied with their provider's communication regardless of their vaccine decisions.

Journal: Human vaccines & immunotherapeutics (2022)
Publication types: Journal Article
Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.

An efficient asymmetric synthesis of a potent kras g12c covalent inhibitor, gdc-6036 (1), is reported.The synthesis features a highly atroposelective negishi coupling to construct the key c-c bond between two highly functionalized pyridine and quinazoline moieties by employing a pd/walphos catalytic system.Statistical modeling by comparing computational descriptors of a range of walphos chiral bisphosphine ligands to a training set of experimental results was used to inform the selection of the best ligand,w057-2, which afforded the desired negishi coupling product(ra)-3in excellent selectivity.A subsequent telescoped reaction sequence of alkoxylation, global deprotection, and acrylamide formation, followed by a final adipate salt formation, furnished gdc-6036 (1) in 40% overall yield from starting materials pyridine5and quinazoline6.

Journal: Journal of the American Chemical Society (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.;Research Support, Non-U.S. Gov't