syedzayyan/paper_mill_benchmark huggingface dataset:
Circulating miR-340-5p and miR-506-3p as Two Osteo-miRNAs for Predicting Osteoporosis in a Cohort of Postmenopausal Women

An increasing risk of developing osteoporosis which is characterized by bone production weakness and microarchitectural deterioration is found among postmenopausal women.Micro rnas (mi rnas) are secreted into the circulation from cells of various tissues in response to local disease severity including bone diseases.Herein, we set out to identify candidate mi rnas predictable for osteoporosis incidence in postmenopausal elderly women.Methods.The circulating mi rna expression profiles deposited in the dataset accessioned as gse201543 were downloaded from the geo database.The study included 176 postmenopausal women who underwent bmd testing, including 96 women reporting osteoporosis and 70 women reporting normal bmd.All subjects were submitted their serum samples for measurements of bone metabolism markers.Results.The mi rna expression profiles of the gse201543 dataset were differentially analyzed and found 97 mi rnas being upregulated concomitantly with 31 mi rnas being downregulated in the serum samples between osteoporotic postmenopausal women and postmenopausal women with normal bmd.Osteoporotic postmenopausal women were demonstrated with elevated serum levels of mi r-340-5p and mi r-506-3p when compared to normal postmenopausal women.Pearson correlation analysis demonstrated that circulating mi r-340-5p and mi r-506-3p expressions were increased as bap, β-ctx, and pinp levels increased, but osteocalcin and 25-(oh)vit d levels are declined in osteoporotic postmenopausal women.Results of the receiver operating characteristic (roc) curve and the area under the roc curve (auc) showed circulating mi r-340-5p and mi r-506-3p expressions alone or combined together produced 0.843 auc, 0.851 auc, and 0.935 auc, respectively, when used to predict the incidence of osteoporosis in postmenopausal women.Conclusion.Our work suggested that circulating mi r-340-5p and mi r-506-3p function as osteo-mi rnas in postmenopausal women and may serve as potential noninvasive biomarkers for the incidence of osteoporosis in postmenopausal women.

Journal: Journal of Environmental and Public Health (2023)
Publication types: Research Article;
Circular RNA circFAT1(e2) Promotes Colorectal Cancer Tumorigenesis via the miR-30e-5p/ITGA6 Axis

Circ rnas (circular rnas) are a family of noncoding rnas and have diverse physiological and pathological functions.However, the functions and mechanisms of circ rnas in the development and progression of colorectal cancer (crc) remain largely unknown.Here, we aimed to explore the functions and roles of circ fat1(e2) in crc.Q rt-pcr revealed that circ fat1(e2) in crc tumor tissues was upregulated compared with that in adjacent normal tissues and was also upregulated in crc cell lines.Small interfering rnas (si rnas) against circ fat1(e2) were used to decrease the expression of circ fat1(e2) in hct116 and rko cells in vitro.The roles of circ fat1(e2) in crc cell metastasis and proliferation were then determined by transwell and cck-8 assays.The results showed that circ fat1(e2) silencing markedly suppressed crc growth.Moreover, we identified circ fat1(e2) as a promoter of crc metastasis.Knockdown of circ fat1(e2) evidently reduced hct116 and rko cell migration and invasion.Furthermore, the regulatory relationship between circ fat1(e2) and its target mi rnas was verified by a luciferase reporter assay.We demonstrated that circ fat1(e2) could sponge mi r-30e-5p, which regulated the expression level of integrin α6 (itga6), the downstream target gene of mi r-30e-5p.Rescue assays demonstrated that knockdown of mi r-30e-5p enhanced crc proliferation and migration via itga6.Taken together, our results reveal the novel oncogenic roles of circ fat1(e2) in crc through the mi r-30e-5p/itga6 axis.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
Application of Intelligent Exercise Training Equipment in Clinical Nursing of Neurology Department

To investigate the effect of intelligent exercise training equipment on lower limb function and standing stability of stroke patients with hemiplegia in clinical nursing of neurology department.Forty-eight stroke patients with a course of 1 to 3 months were randomly divided into treatment group and control group, with 24 cases in each group.The control group was treated with conventional rehabilitation training, and the treatment group was treated with intelligent training system, twice a day, 20 min each time.Lower extremity motor function (using the fma-l scale) and walking function (using the functional walking scale fac) were assessed before treatment and 4 weeks after treatment.The results showed that there was no statistical difference between the control group and the treatment group in the t-test of lower limb motor function scores before rehabilitation treatment ( p &gt; 0.05 ).After treatment, the lower extremity motor function scores of the two groups were tested by group design t-test, and the results showed that there was a significant difference between the two groups ( p &lt; 0.05 ); the effect of the treatment group was significantly better than that of the control group ( p &lt; 0.05 ).Intelligent exercise training equipment combined with routine rehabilitation therapy in clinical nursing of neurology department could improve the lower extremity motor function and walking ability of patients with convalescence stroke hemiplegia, and the effect was better than that of routine rehabilitation therapy alone.

Journal: Contrast Media & Molecular Imaging (2021)
Publication types: Clinical Study;
Application Effect Analysis of Operating Room Detailed Nursing Based on Medical Big Data in Patients Undergoing Gastrointestinal Tumor Surgery

With the continuous development of internet information computing, the continuous improvement of medical and health systems, and the continuous increase of medical big data, traditional operating room care also needs to be further optimized.Medical big data is a forum data set for medical industry healthcare, electronic medical record information, clinical case record information, medical financial data, remote patient monitoring data, clinical decision support data, medical insurance data set, online consulting platform, and so on.Gastrointestinal tumors are currently one of the largest malignant tumors.Compared with ordinary patients, the presence of fear, depression, irritability, and other unhealthy emotions in patients with gastrointestinal tumors will reduce the therapeutic effect.Without careful care, the use of chemotherapy and other treatments makes patients vulnerable to various side effects.This article aims to study the use of medical big data intelligent algorithms to perform detailed care for patients during gastrointestinal tumor surgery and analyze the effects of care.This paper proposes an improved dnn algorithm; the dnn algorithm is to use several weight coefficient matrices and bias vectors to perform a series of linear operations and activation operations with the input value vector, starting from the input layer, backward calculation layer by layer, until the operation reaches the output layer, and the output result is obtained.This algorithm is used to study the theory, use mathematical formulas for method calculation and model design, and use the model to carry out detailed nursing experiments in the relevant operating room.The results of the experiment show that patients who have performed detailed care have a 27.2% improvement in treatment and rehabilitation effects than those who have not, and the level of detailed care has an obvious positive relationship with the rate of condition conversion.In the end, the hospital’s detailed care quality evaluation index, which is qei, increases by 1 point, which can increase the rate of condition conversion by 0.4.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Analysis on the Influence of Students’ Health Quality Based on Intelligent Optimization of Sports Facilities and Equipment

Physical health promotion has always been a way for schools to pay close attention to and devote resources to their students’ development, physical fitness, and social adaptability.To promote the improvement of students’ overall physical quality, we must begin with the foundation and school physical education.This study proposes an improved k-means algorithm based on an analysis of the influencing factors of intelligent optimization of sports facilities and equipment on students’ health quality.Clustering analysis is carried out based on two groups of data classified as boys and girls, using the improved k-means algorithm.The findings reveal that the average change trend of physical fitness test items in each male cluster is generally similar, with a moderate change.The change in the average score of physical fitness test items for each cluster of girls in the group showed two distinct valleys, and the trend was complicated.This necessitates schools to invest funds to construct venues and purchase equipment in order to increase the number of sporting events.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Analysis on the Development and Influence of National Fitness Environment on Youth Basketball Coordination and Mental Health

In order to improve the basketball theory and provide theoretical and intellectual support for the scientific, mental health, and sustainable development of basketball, we propose to take the development dynamic mechanism of juvenile basketball as the research object and make a systematic and in‐depth study on the dynamic mechanism, the cultivation of chinese and foreign juvenile basketball reserve talents, and the dynamic dilemma and influencing factors of juvenile campus basketball development by using the methods of literature, questionnaire, and expert interview.A method of cultivating the ring tone of juvenile basketball is proposed.This method is based on chan algorithm.When the target is close to each base station, the first estimation also needs an initial value to solve the initial solution estimation matrix.The method is also based on multivariate taylor algorithm, taking into account the measured distance between the targets to be measured, so it will get some useful information, which will improve the positioning accuracy.The experimental results show that the accuracy of the algorithm used in this paper is more than 85%.However, the accuracy of rebounding and passing recognition and prediction is low.The recognition accuracy and prediction accuracy of the test set are slightly lower than that of the effective set, which shows that the performance of the target detection system model in this paper can be further improved through more significant training examples.It is proved that the algorithm based on taylor ring can meet the needs of teenagers in the basketball coordination and mental health.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
Analysis of the Relevant Vital Signs and Infection of Sepsis Patients and to Explore the Influencing Factors of Acute Lung Injury/Acute Respiratory Distress Syndrome

In order to analyze the relevant vital signs and infection of sepsis patients, the influencing factors of acute lung injury/acute respiratory distress syndrome (ali/ards) are explored.A total of 142 sepsis patients admitted to our hospital from january 2019 to january 2022 are divided into an ali/ards group and a non‐ali/ards group according to the incidence of ali/ards.Logistic analysis showed that pulmonary/abdominal infection, fungal origin of infection, acinetobacter baumannii , low oxygenation index, high blood lactic acid value, apache ii score, sofa score, and lips score are the risk factors for sepsis‐induced ali/ards.The results indicate that pulmonary/abdominal infection, fungal origin of infection, acinetobacter baumannii , low oxygenation index, high blood lactic acid, apache ii score, sofa score, and lips score are the risk factors for sepsis induced ali/ards.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Analysis of the Relationship between Employee Health Level and Building Office Space and Environment

The arrival of the era of big data provides new research methods and perspectives.In view of the problem that the current building office space environment design does not consider the level of human health, which leads to the low comfort and the poor environmental quality of building office space, this paper puts forward the comfort analysis and environment design of building office space considering the health level of employees.By analyzing the theoretical basis of architectural office space by big data, the paper studies the elements and the esthetic characteristics of architectural office space, understands the development and classification of architectural office space, and obtains the esthetic characteristics of architectural office space.Considering the health level of employees, the factors affecting the comfort of building office space are analyzed.The research object is selected as a building office space; the method of questionnaire survey is used for the establishment of building office space comfort evaluation factor set; and from the two aspects of enterprise employees’ psychological behavior and physical environment, the comfort of building office space of the research object is analyzed.The results of case study show that the proposed method has good environmental quality of building office space and can effectively improve the comfort of building office space.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
Analysis of the Influence of Nursing Safety Management on Nursing Quality in Hemodialysis Room

The influence of the nursing safety management in nursing quality of hemodialysis room was deeply analyzed through the evaluation index study of nursing quality in hemodialysis room.Sixty-two patients were selected from hemodialysis rooms as study samples, and 31 patients who had not carried out nursing safety management from september 2018 to september 2019 were selected as control samples.Thirty-one patients who underwent nursing safety management from september 2019 to september 2020 were included in the observation group.By comparing the samples of the control group and the observation group, it was found that the comprehensive score of adverse reaction risk nursing quality and nursing satisfaction score between the groups were significantly improved; p &lt; 0.05.Nursing safety management can effectively reduce the quality of nursing in hemodialysis room and greatly reduce the occurrence of adverse risks.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Clinical Study;
Analysis of the Influence of Geographical Environment on Chinese Ethnic Folk Dance, Taking the Development of Dance Curriculum in Huaihua No. 1 Middle School as an Example

Among the treasures of chinese art, ethnic dance is an important part.As a key form of expression of national art and emotion, dance has strong regional and gender characteristics for those affected by different ethnic groups and regions.The unique characteristics of the region are the driving force for the masses of all ethnic groups in china to continuously promote the prosperity and development of ethnic and folk dances living alone in different living conditions and living environments.In the analysis of ethnic and folk dances, environmental elements have a profound impact on the rapid development of dance.The main reason for folk dance is the relationship between the costumes of the dance, the connotation of the dance, and the laws of nature, resulting in the derivation of the environment.The article will also focus on a more in‐depth discussion and analysis of the characteristics of chinese folk dance.Scientific research on the regionality of ethnic dance plays a vital role in understanding and inheriting ethnic and folk dances.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
Analysis of the Effect of DPL Combined with Clarithromycin in the Therapy and Improvement of Rosacea

Rosacea is a chronic inflammatory skin disease with a high incidence, and it leads to negative emotions such as inferiority complex, increased psychological pressure, and a greatly reduced quality of life.In order to investigate the clinical efficacy of dpl combined with clarithromycin in the treatment and improvement of rosacea.86 patients with rosacea were selected and randomly divided into the control group and study group according to the random number table method.The results show that the combination of dpl and clarithromycin in the treatment of rosacea patients can effectively improve the clinical symptoms of patients, improve the therapeutic effect, and the incidence of adverse reactions is low, which ensures that the patients have a good prognosis, which is worthy of clinical application.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Clinical Study;
Therapeutic Effect Analysis of Plasma Bipolar Intelligent Electrotonic for Cystostomy in the Treatment of Senile Prostatic Hyperplasia

To solve prostatic hyperplasia in the elderly, a method of cystostomy with plasma bipolar resection was proposed.From january 2019 to march 2020, 42 patients with bph who needed surgical treatment in the urological department were selected.Cystostomy was performed in bipolar turp.The cystostomy group and robot group were divided into two groups.The surgical safety, surgical efficiency, complications, and nursing time between the two groups were compared.The results showed that the experimental and control groups’ ruv values were significantly lower than those before surgery.In comparison, the qmax value was considerably higher than that before surgery.The difference was statistically significant ( p &lt; 0.05 ), suggesting that the cystostomy group in bipolar turp had more substantial improvement of dysuria, better recovery of detrusor function, and better prognosis.It was proved that, for bph below 80 g, cystostomy could reduce the operation time, bladder irrigation time, catheter indwelling time, and postoperative hospital stay, improve the operation efficiency, and have the same effect on patients’ symptoms improvement, more excellent psychological support, and higher quality of life score.It is proved that plasma bipolar resection combined with cystostomy can effectively improve annual bph surgery.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Clinical Study;
The Value of Nuclear Magnetic Resonance in Liver Nodular Lesions

In order to analyze the value of contrast‐enhanced ultrasound (ceus) combined with functional magnetic resonance imaging (f mri) in the early differential diagnosis of liver nodular lesions, the authors studied the value of mri in liver nodular lesions.A total of 82 patients with liver nodular lesions admitted to the hospital were selected for retrospective analysis; all of them underwent ceus and f mri examinations, and taking a biopsy or postoperative pathological examination results as the gold standard, the diagnostic value of ceus, f mri single item, and the two combined examinations for liver nodular lesions was analyzed by four‐table.The biopsy or postoperative pathological examination results showed that a total of 88 lesions were detected in 82 patients, including 51 patients with benign lesions, with 54 lesions, and 31 patients with malignant lesions, with 34 lesions.Taking biopsy or pathological examination results as the gold standard, the four‐table analysis ceus had a sensitivity of 79.63%, a specificity of 82.35%, an accuracy of 80.68%, and a kappa value of 0.603 for diagnosing benign and malignant liver nodular lesions.The sensitivity of f mri in diagnosing benign and malignant liver nodular lesions was 83.33%, the specificity was 85.29%, the accuracy was 84.09%, and the kappa value was 0.672; the combined sensitivity of the two in the diagnosis of benign and malignant liver nodular lesions was 94.44%, the specificity was 91.18%, the accuracy was 93.18%, and the kappa value was 0.856, both of which were superior to single detection, and the difference in accuracy was statistically significant ( χ 2 = 5.683, p &lt; 0.05).Ceus and f mri have a certain value in the differential diagnosis of liver nodular lesions; the combination of the two can improve the diagnostic sensitivity and accuracy, and has more clinical application value.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
The Radiographic Changes of Catheter Tip in Different Positions of Arm Infusion Port

In order to investigate the influence of patient position change on the position of catheter tip in arm infusion port, the clinical data of 324 patients undergoing arm infusion port implantation in a hospital were retrospectively analyzed.It could be obtained that tivap was successfully implanted in 324 patients with malignant tumors.In 171 cases, the tivap catheter tip shifted to the foot side when the position was changed from upright to decubitus, with an average displacement of (12.29 ± 7.48) mm; 149 cases had cephalic displacement with an average of (5.00 ± 3.79) mm; and 5 cases had no change.The position of the tivap catheter tip tended to shift to the foot side when the vertical position changed to the decubitus position, with an average displacement of (−9.32 ± 9.36) mm, and the difference had statistical significance ( p &lt; 0.0001), while there were no significant differences in gender, age, height, weight, body mass index, and catheter tip position ( p &gt; 0.05).It could be analyzed from the data that from decubitus to upright position, the tip of the arm infusion port tended to shift to the foot side, and the moving distance was related to the patient’s gender, sebum thickness, and indwelling catheter length.Preoperative understanding of relevant information is helpful to determine the location and length of catheterization and reduce catheter‐related complications.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Analysis of the Correlation of Basic Fibroblast Growth Factor in Serum of Patients with Diffuse Large B-Cell Lymphoma with Clinicopathological Efficacy and International Prognostic Index

The correlation of basic fibroblast growth factor (b fgf) in serum of patients with diffuse large b‐cell lymphoma (dlbcl) with clinicopathological efficacy and international prognostic index (ipi) is analyzed.115 dlbcl patients admitted to our hospital for treatment from june 2020 to june 2021 are selected as the dlbcl patient group, 65 healthy subjects who received physical examination in our hospital during the same period are selected as the healthy control group, and the serum b fgf levels of dlbcl group and healthy control group are observed before treatment.The experimental results show that the serum b fgf expression of dlbcl patients is decreased significantly after chemotherapy, and the serum b fgf expression of dlbcl patients is closely related to the treatment effect, disease progression, tumor invasion, and prognosis, which has important clinical significance for judging the disease, treatment effect, and prognosis of patients.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;