syedzayyan/paper_mill_benchmark huggingface dataset:
Influences of Airway Obstruction Caused by Adenoid Hypertrophy on Growth and Development of Craniomaxillofacial Structure and Respiratory Function in Children

Adenoid hypertrophy (ah) is a common disease in otorhinolaryngology.Children with chronic snoring and hypoxia are susceptible to long-term nasal obstruction, while long-term open-mouth breathing may cause craniofacial bone development disorders and dull facial expressions, the so-called adenoid face.The purpose of this work is to analyze the influence of ah-induced airway obstruction (ao) on the growth and development of craniomaxillofacial structure and respiratory function (rf) in children.The clinical data of 56 ah children (observation group) and 42 healthy children with physical examination (control group) who visited the hebei eye hospital during the same period were retrospectively analyzed.All children received acoustic rhinometry and x-ray cephalometric measurements.The upper airway structure, sleep disorder score, and a / n value of nasopharyngeal lateral x-ray images were compared between cases and controls.For ah children, sleep tests were also performed to assess their rf.X-ray cephalometric measurements of facial morphology showed obvious vertical growth, mandibular retrognathia, and enlarged mandibular angle in ah children.Ah mainly affects the size of the nasopharyngeal and oropharyngeal airway.Ah children presented with higher nasal airway resistance ( 5.11 ± 1.95 cm h2o/l min) and lower nasopharyngeal volume (npv) ( 16.86 ± 3.93 cm3) than controls.Of the ah children, 45 had abnormal rf, including 4 with obstructive sleep apnea syndrome.The a / n value of nasopharyngeal lateral x-ray images was significantly higher in ah children than in controls.Besides, worse sleep quality was found in ah children.The above differences were all of statistical significance.The above indicates that ah can affect the size of the nasopharyngeal and oropharyngeal airway, change children’s respiratory mode and rf, increase nasal resistance, and decrease npv, resulting in upper respiratory tract stenosis, as well as craniomaxillofacial and oral malformations, which affects children’s normal growth and development.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Influence of Melatonin on Behavioral and Neurological Function of Rats with Focal Cerebral Ischemia-Reperfusion Injury via the JNK/FoxO3a/Bim Pathway

To investigate the influence of melatonin on behavioral and neurological function of rats with focal cerebral ischemia-reperfusion injury via the jnk/fox o3a/bim pathway.Methods.One hundred and twenty healthy male sd rats were randomized into the model group (model: the middle cerebral artery occlusion (mcao) model was constructed and received an equal volume of normal saline containing 5% dmso), sham operation group (sham: received no treatment except normal feeding), and low, medium, and high dose of melatonin group (l-mt, m-mt, and h-mt intraperitoneally injected 10, 20, and 40 mg/kg melatonin 30 min after ir, respectively), with 24 rats in each group.Following 24 h of reperfusion, the rats in each of the above groups were tested for neurological deficit symptoms and behavioral changes to screen the rats included in the study.He and tunel stainings were performed to observe pathological changes.Levels of oxidative stress-related indexes, inflammatory factor-related indexes, nuclear factor-κb p65 (nf-κb p65), and interferon-γ (ifn-γ) in the rat brain were measured by elisa.The jnk/fox o3a/bim pathway-related proteins as well as bcl-2, caspase-3, and bax were examined using western blot.Results.Detection of behavioral indicators showed that the maco model was successfully constructed in rats.L-mt, m-mt, and l-mt groups presented reduced malondialdehyde (mda), reactive oxygen species (ros), tumor necrosis factor- (tnf-) α, interleukin- (il-) 6, il-1β, ifn-γ, nf-κb p65, and apoptosis compared with the model group ( p &lt; 0.05 ), and the improvement degree was better in the m-mt group versus the l-ht group.Bcl-2 protein expression in the brain tissue of l-mt, m-mt, and h-mt groups increased significantly, while bax, caspase-3, p-jnk, p-fox o3a, and bim protein expression declined markedly, versus the model group ( p &lt; 0.05 ).The changes of indexes were greater in the m-mt group compared with that in the l-mt group.No significant difference was observed in all the above indexes between the m-mt group and the h-mt group ( p &gt; 0.05 ).Conclusions.In the maco rat model, melatonin can effectively reduce bax and caspase-3 levels by modulating the jnk/fox o3a/bim pathway, inhibit neuronal apoptosis, and alleviate neurological deficits by reducing the release of proinflammatory mediators, with anti-inflammatory and antioxidant effects.In addition, 20 mg/kg is the optimal melatonin concentration.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Incidence of Adverse Effects of Propofol for Procedural Sedation/Anesthesia in the Pediatric Emergency Population: A Systematic Review and Meta-Analysis

To investigate the incidence of adverse effects of propofol among pediatric population for sedation or anesthesia.Methods.We performed cochrane library, pub med, cnki, vip, and wanfang databases to research relevant literature.We did sensitivity analysis to assess the incidence of adverse effects of propofol among pediatric population for sedation or anesthesia.Results.In 132 studies, eight rcts were included in this analysis.The result showed that adverse events (bradypnea, hypotension, hypertension, and apnea) were significantly improved in the pediatric emergency population in the propofol group, but it had no effect on the incidence of cough attacks, desaturation, agitation, stridor, and laryngospasm.Furthermore, the subgroup analysis showed that those who received propofol for had decreased adverse effects compared with the patients who received ketamine treatment ( smd = 0.44 , 95 % ci = 0.28 , 0.67 , i 2 = 0 %, and p = 0.0002 ), which demonstrated that propofol could decrease the incidence of adverse effects compared with ketamine and ketofol.Conclusions.The study demonstrated that propofol may decrease the incidence of bradypnea, hypotension, hypertension, and apnea, but it had no effect on the incidence of cough attacks, desaturation, agitation, stridor, and laryngospasm.Furthermore, more large rcts are needed to assess incidence of adverse effects of propofol among pediatric population.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Meta-Analysis;
Incidence and Influencing Factors of Chronic Postthoracotomy Pain in Lung Tumor Patients

S.To estimate the incidence of chronic postthoracotomy pain (cptp) in lung tumor patients and to explore the influencing factors of the intensity of cptp.Methods.Lung tumor patients who underwent video-assisted thoracoscopic surgery (vats) or thoracotomy were consecutively recruited from october 2016 to december 2017 at yunnan cancer hospital.All the eligible patients were interviewed via telephone at the end of the third month after surgeries to identify the presence of cptp.The potential influencing factors of cptp, including pre-, intra-, and postoperative variables, were collected from medical records.A cumulative logit regression model was used to identify the independent influencing factors of the intensity of cptp.Results.Three hundred and forty-three patients completed a telephone interview.The estimated overall incidence of cptp was 67.6% (95% of confidence interval, 95% ci: 62.4%, 72.6%) in lung tumor patients; 70.8% (95% ci: 63.8%, 77.1%) in benign patients and 63.5% (95% ci: 55.2%, 71.3%) in malignant patients; and 78.1% (95% ci: 66.0%, 87.5%) in open chest and 65.2% (95% ci: 59.3%, 70.8%) in vats.Cumulative logit regression models (intensity order, nrs, 0 ⟶ 1–3 ⟶ 4-) revealed independent influencing factors of cptp to be patients with diabetes (or = 0.32; 95% ci: 0.14, 0.76), usage of vats (or = 0.47; 95% ci: 027, 0.82), and the amount of intraoperative blood loss (or = 1.09; 95% ci: 1.00, 1.19).Conclusions.A high incidence of cptp is detected in lung tumor patients following the thoracic operation.Patients with diabetes and using vats are the independent protective factors of the intensity of cptp, and the increasing amount of intraoperative blood loss is an independent risk factor of the intensity of cptp.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Incentive Nursing can Effectively Improve the ESCA Level of Patients with Endometrial Cancer after Laparoscopic Hysterectomy

To investigate the effect of incentive nursing on the rehabilitation of patients with endometrial cancer after laparoscopic hysterectomy.Methods.A total of 110 patients with endometrial cancer receiving laparoscopic hysterectomy in our hospital from october 2017 to july 2020 were recruited and assigned at a ratio of 1 : 1 to receive either routine nursing (control group) or incentive nursing plus routine care (study group).Outcome measures included the self-rating anxiety scale (sas) score, hamilton depression scale (hamd) score, the exercise of self-care agency (esca) score, postoperative rehabilitation outcomes, the incidence of nursing complications, and nursing satisfaction.Results.Patients receiving incentive nursing showed significantly lower sas scores and hamd scores, and a higher esca score versus patients given routine care alone ( p &lt; 0.05 ).Incentive care resulted in a shorter length of hospital stay and postoperative time of out-of-bed activities and exercises versus routine care ( p &lt; 0.05 ).Incentive care was associated with a significantly lower incidence of nursing complications and higher nursing satisfaction versus routine nursing ( p &lt; 0.05 ).conclusion.Incentive nursing can effectively improve the esca level of patients, promote postoperative recovery, and reduce the incidence of complications, so it is worthy of clinical promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Improved Outside-In Suture through the Joint Capsule to Repair the Palmer I-B Triangular Fibrocartilage Complex Superficial Injury

The treatment of type i-b triangular fibrocartilage complex superficial injury is always a challenge to orthopedists.The traditional outside-in suture method often causes a risk of nervous irritation.We designed a modified outside-in suture through the joint capsule to repair the palmer i-b triangular fibrocartilage complex superficial injury.Methods.From december 2014 to december 2018, we retrospectively collected the medical records of 18 patients in our hospital who used the modified outside-in suture through the joint capsule to repair type i-b triangular fibrocartilage complex superficial injury.Among them, there were 12 males and 6 females, with an average age of 36.2 years.There were 6 cases on the left side and 12 cases on the right side.Record the healing time of all patients after surgery and the occurrence of related complications, and record the pain visual analogue scale (vas), grip strength, wrist flexion and extension, radioulnar deviation and forearm rotation range of motion, modified mayo wrist joint function score, and disability of arm-shoulder-hand (dash) score before operation and at the last follow-up.Results.One patient was lost to follow-up, and a total of 17 patients received the final follow-up.Patients were followed up for 24 to 36 months, with an average of 29.6 ± 3.0 months.No wound infection, nerve damage, or irritation occurred after the operation.At the last follow-up, 15 cases of wrist pain disappeared completely, and 2 cases had mild discomfort during exercise.At the last follow-up, vas decreased from 3.8 ± 0.7 points before operation to 0.8 ± 0.7 points ( p &lt; 0.05 ); grip strength increased from 15.1 ± 3.1 kg before operation to 23.2 ± 1.5 kg ( p &lt; 0.05 ); wrist flexion and extension, radioulnar deflection, and forearm rotational mobility increased from 116.3 ± 2.2 °, 37.0 ± 3.5 °, and 141.6 ± 2.2 ° before operation to 117.2 ± 2.5 ° ( p &lt; 0.05 ), 38.9 ± 3.0 ° ( p &lt; 0.05 ), and 142.4 ± 1.9 ° ( p &lt; 0.05 ), respectively; the modified mayo wrist joint function score increased from 66.1 ± 3.6 points to 82.5 ± 3.9 points ( p &lt; 0.05 ), of which 10 cases were excellent, 5 cases were good, 2 cases were fair, and the excellent and good rate was 88.2%; dash score improved from 37.0 ± 5.7 points preoperatively to 8.0 ± 2.5 points ( p &lt; 0.05 ).Conclusion.The modified outside-in suture through the joint capsule to repair the superficial injury of palmer i-b triangular fibrocartilage complex has a good clinical effect and is worthy of clinical widespread promotion.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
Implications of Human Antimicrobial Peptide Defensin Beta-1 in Clinical Oral Squamous Cell Carcinoma Patients via an Integrated Bioinformatics Approach

The human antimicrobial peptide defensin beta 1 (defb1) has been found to play antimicrobial and anti-inflammatory roles in oral diseases; however, its tumor-regulating role in oral squamous cell carcinoma (oscc) has not yet been researched by using an integrative bioinformatics approach.Objective.To investigate the regulating mechanisms of the defb1 gene in oscc in terms of its expression patterns, prognostic values, biological functions, and implication for tumor immunity.Methods.The defb1 gene expression pattern and regulatory involvement in oscc were investigated using publically accessible data from tcga database.R software tools and public web servers were utilized to conduct statistical analysis of data from cancer and noncancerous samples.Results.Defb1 was found to be significantly downregulated in oscc tumor samples compared with healthy control oral samples.The defb1 gene was found associated with the prognostic outcomes of oscc, and its upregulation represented better survival outcome.Gene set enrichment analysis (gsea) results showed that defb1-significantly correlated genes were mainly enriched in four signaling pathways mediating the antitumor role of defb1 in oscc, including extracellular matrix-related pathway, rtk/pi3k/akt/m tor pathway, keratinization, and cytokine-related pathway.The gene-gene interaction network showed that defb1 was closely correlated with several genes, for example, ccr6 (c-c motif chemokine receptor 6), cxcl1 (c-x-c motif chemokine ligand 1), map4k2 (mitogen-activated protein kinase kinase kinase kinase 2), ptger3 (prostaglandin e receptor 3), and mmp7 (matrix metallopeptidase 7).Moreover, defb1 was found to be involved in the tumor immunity of oscc by regulating the function of tumor macrophage cells, mast cells, t cells, and nk cells.Conclusions.Given the dysregulation, prognostic value, and tumor progression-related biological pathway alteration, indicating the tumor immune-modulatory role of defb1 in oscc, the defb1 gene should be regarded as a potential therapeutic target for treating oral cancer.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Implementation of Driving Safety Early Warning System Based on Trajectory Prediction on the Internet of Vehicles Environment

Traffic accidents cause a large number of casualties and economic losses every year.The primary causes of traffic accidents are the inadvertent response and inappropriate disposal of drivers.The internet of vehicles system is a large network based on intranets, the internet, and mobile internet.It performs wireless communication and information exchange between vehicles and roadways in accordance with the agreed-upon communication protocol and data exchange standards.It provides technical assistance in the implementation of vehicle hazard detection and opens up new avenues for safety early warning.In this study, a driving safety early warning system is proposed based on trajectory prediction on the internet of vehicles environment.After analyzing the system requirements, the driving safety system based on trajectory prediction is designed according to the demand analysis and tested.The trajectory prediction error is detected, and the collected trajectory is predicted.Data are divided into 3 groups, and to validate the performance of the system, the experiment is repeated five times.The test results show that the trajectory prediction accuracy of the trajectory prediction system designed is 89.4%, as compared to the accuracy of existing driving safety early warning systems, most of which are concentrated at accuracy lower than 89%.The proposed early warning method has the potential to reduce vehicle collisions and road traffic accidents.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Impacts of Angelica Polysaccharide on Proliferation and Differentiation of Mesenchymal Stem Cells of Rat Bone Marrow

In literature, antiosteoporotic effects of angelica sinensis root have been confirmed, but the impact of angelica sinensis polysaccharide (asp) on osteoblastic or adipogenic distinction of bmscs is limited.This paper aimed to explore the role of asp on proliferation and differentiation of rat bmscs.Rat bmscs were subjected to isolation and identification through flow cytometry.The proliferation of rat bmscs under asp was performed by cck-8 kit.Measures of osteogenesis under different concentrations of asp were detected by using alizarin red staining for mesenchymal cells differentiation and alp activity assay to identify alp activity.Quantitative rt-pcr was selected to identify osteoblastic or adipogenic biomarkers from a genetic perspective.Likewise, we have evaluated measures of indicators of wnt/β-catenin signal.Asp significantly promoted the proliferation, increased osteogenesis, and decreased adipogenesis of rat bmscs within the limit of 20–60 mg/l in a dose-dependent manner but was suppressed at 80 mg/l.The expression of cyclin d1 and ß-catenin showed a considerable rise over the course of asp induced osteogenesis.Dickkopf 1 (dkk1) suppressed the regulation of rat bmscs differentiation through the mediation of asp.We have observed that asp upregulated the osteogenic but downregulated adipogenic differentiation of bmscs, and our findings help to contribute to effective solutions for treating bone disorders.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Impact of Systematic Holistic Nursing Combined with Narrative Nursing Intervention for Patients with Advanced Gastric Cancer on Complications and Negative Emotions

The aim of this study is to evaluate the influence of systemic holistic nursing combined with narrative nursing on the postoperative complications and negative emotions in patients with advanced gastric cancer.Methods.A total of 120 patients with advanced gastric cancer admitted to our hospital between february 2020 and february 2021 were recruited and assigned to receive systemic holistic nursing combined with narrative nursing (experimental group) or systemic holistic nursing (control group) according to order of admission, with 60 cases in each group.The outcome measures included the incidence of postoperative complications, negative emotion score, quality of life score, self-efficacy score, self-care ability score, and nursing satisfaction.Results.The experimental group had a significantly lower incidence of complications and lower negative emotion scores than the control group ( p &lt; 0.001 ).Systemic holistic nursing plus narrative nursing resulted in significantly higher life scores, self-efficacy scores, and self-care ability scores in the experimental group after nursing than in the control group ( p &lt; 0.001 ).Patients of the experimental groups were more satisfied with the nursing in contrast to those in the control group ( p &lt; 0.001 ).Conclusion.Systematic holistic nursing plus narrative nursing alleviates the negative emotions of patients, improves their self-efficacy scores, lowers the incidence of complications, and enhances quality of life.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Imaging Diagnosis of Primary Solitary Bone Neoplasts and Its Comparison with Tumor-like Lesions

To explore the imaging diagnostic value of primary solitary bone tumor and tumor-like lesion of iliac crest.Methods.A total of 156 patients with primary solitary bone tumors and tumor-like lesions of the iliac bone treated in our hospital were selected, and the patients were diagnosed by x-ray, ct, and mri.Sexual analysis of single diagnostic and combined diagnostic value was carried out.Results.Round high-density shadow, soft tissue mass shadow, soft tissue mass, right intestinal tube, and bladder obvious pressure were observed.The detection rates of giant cell tumor of bone, myeloma, osteochondroma, chondroma, eosinophilic granuloma, osteosarcoma, fibrous dysplasia, and hodgkin lymphoma were 34.6%, 12.8%, 11.5%, 10.3%, 7.7%, 6.4%, 3.8%, and 2.6%, and the differences were statistically significant (p &lt; 005); x-ray, ct, mr single diagnostic comparison, three methods joint diagnostic missed diagnosis rate and misdiagnosis rate, higher detection rate ( p &lt; 0.05 ); combined with x-ray, ct, mr single diagnosis, three methods joint diagnosis sensitivity, specificity, accuracy, statistical significance ( p &lt; 0.05 ); comparison with x-ray, ct, mr single diagnosis, three methods jointly diagnosed positive predictive value, negative predictive value higher, difference statistics significance ( p &lt; 0.05 ); there is a significant difference in the near-end, backbone, and distal detection rate of different bone tumors and tumor lesions, including the humerus and tibia.There is a statistical significance of the detection rate, and the difference is p &lt; 0.05 .Conclusion.X-ray plays an important role in the diagnosis of primary solitary bone tumor and tumor-like lesion of iliac crest and is the first choice in clinical diagnosis.In the diagnosis of tumor disease, range, and soft tissue mass, mri and ct diagnostic value can provide effective theoretical basis for patient clinical treatment.Therefore, the appropriate diagnostic method should be selected according to the specific situation of the patient, so that the efficiency of the clinical feature is improved.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Image Recognition about Stability of Soft Surrounding Rock in Tunnel Based on ILBP Algorithm

With china’s fast expansion of urban traffic and railway engineering, a great number of subway and railway lines have been erected in subterranean tunnels in recent years.When the tunnel is in the process of construction, it will encounter the weak fracture zone, and the surrounding rock of this part of the tunnel is often poor stability and deformation is difficult to control, which will lead to the smooth progress of the project, delay and other problems.Therefore, to facilitate the timely treatment of tunnel soft surrounding rock, the study of image recognition of its stability is particularly important.Based on this, an improved local binary mode algorithm (ilbp) is proposed in this paper.By adjusting the weight of binary polynomial in local binary mode (lbp) operator, the target of ilbp is to extract the characteristics of weak surrounding rock of tunnel at a specific location, hoping to provide reference for the follow-up study of tunnel engineering.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;