syedzayyan/paper_mill_benchmark huggingface dataset:
Energy-Efficient and Secure Opportunistic Routing Protocol for WSN: Performance Analysis with Nature-Inspired Algorithms and Its Application in Biomedical Applications

Wireless sensor network (wsn) is made up of tiny sensor nodes.The application of wsn in diverse fields has seen a tremendous escalation in recent years.Wsn applications are constrained by the limited set of computing resources possessed by the sensor nodes and the security aspects of data communication in the wsn.Many algorithms based on nature‐inspired optimization (nio) have been proposed in the past to optimize the issue of energy efficiency and security in wsn.In the proposed work, two opportunistic routing algorithms, i.e., intelligent opportunistic routing protocol (iop) and trust‐based secure intelligent opportunistic routing protocol (tbsiop), are compared against two nio algorithms developed for achieving energy efficiency and security in wsn for performance analysis.The performance is evaluated by simulating the algorithms on matlab and comparing the obtained results with existing aco‐based and pso‐based routing algorithms.It is observed that the tbsiop outperforms the nio‐based algorithms in terms of energy efficiency, network lifetime, packet delivery ratio, end‐to‐end delay, and average risk level.All the parameters under consideration are recorded in the presence of a maximum of 50% malicious nodes for 25, 50, and 100 nodes’ test cases.The increasing size of the network has a significant effect on the performance of tbsiop, as the packet delivery ratio is close to 100%.Also, tbsiop can easily avoid malicious nodes during the routing process as reflected from the results.This will improve the network lifetime of tbsiop compared to other protocols.As far as the application of the work is concerned, it would be beneficial for smart healthcare services.It can also help in better communication during the sharing of data by providing energy‐efficient services and keeping the network alive for a longer period.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Empirical Investigation on the Characteristics and Perceived Value of Patients in Medical Treatment Seeking: In-Depth Research in Zhejiang Province of China

Patient perceived value (ppv) provides a valuable perspective to explain why the government reforms on health system in terms of functional medical treatment performance improvement did not decrease the crowded waiting line or increased patient satisfaction in china.Methods .Questionnaires comprising seven constructs were sent to patients from seven highly recognized hospitals in zhejiang province of china.It was collected via face‐by‐face in a twelve‐month period (2019), and 2586 valid data were collected for spss statistic accordingly.Results .Besides the significance of the functional medical treatment values (such as the treatment effectiveness, accurate price, standardization, and normalization), the emotional values (reasonable waiting time, convenient accessibility, communication with doctors/nurses) were significant in patients’ consciousness.Patient medical treatment seeking preferences were affected by patients’ background characteristics and perceived value, which consequently produced differentiated patients’ satisfaction.Patients’ characteristics, which related to the age, gender, illness conditions, educational, and income level, would have different demanding in medical treatment seeking.These young female patients in outpatient or in mild illness conditions with higher educational and income levels tend to be relatively high in timing and convenience demanding.Conclusion .This result would change the policy maker and hospitals to considerate the patients’ emotional value as well as functional value in providing medical treatment.Classified patients’ time arrangement tactics consistent with distinguished characteristics, equipped up with convenient accessibility and interconnected medical treatment environment design, can create valuable patients’ satisfaction in china.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Efficacy and Safety of Bifidobacterium Quadruple Viable Bacteria Combined with Mesalamine against UC Management: A Systematic Review and Meta-Analysis

To systematically assess effectiveness and safety of bifidobacterium quadruple viable bacteria combined with mesalamine against ulcerative colitis (uc) in the asian population.Methods.An electronic search was conducted in pub med, embase, cochrane library, cnki, vip, and wanfang databases for a random collection of controlled trials of bifidobacterium quadruple viable bacteria combined with mesalamine against uc.Following data screening and extraction, a cochrane risk assessment tool was adopted to evaluate the quality of the included studies, and rev man 5.3 and stata/se 15.1 software were used for meta-analysis.Results.nineteen articles which enrolled 1,707 subjects were included ultimately in this study.The experimental group performed better than the control group in improving the mayo score ( md = − 1.94 , 95% ci = − 2.69 , − 1.19 , p &lt; 0.00001 ), increasing the total clinical efficiency ( or = 5.10 , 95% ci (3.53, 7.38), p &lt; 0.00001 ), reducing the levels of il-8 ( smd = − 1.79 , 95% ci (-2.36, -1.12), p &lt; 0.00001 ), increasing the levels of il-4 ( smd = 1.00 , 95% ci (0.60, 1.41), p &lt; 0.00001 ), and reducing the levels of hs crp ( md = − 3.26 , 95% ci (-4.28, -2.25), p &lt; 0.00001 ), tnf-α ( md = − 7.11 , 95% ci (-9.23, -5.00), p &lt; 0.00001 ), ox-ldl ( md = − 14.46 , 95% ci (-17.20, -11.72), p &lt; 0.00001 ), and lpo ( md = − 3.55 , 95% ci (-4.70, -2.39), p &lt; 0.0001 ) as well as increasing sod level ( smd = 1.68 , 95% ci (1.02, 2.35), p &lt; 0.00001 ), and adverse reactions were substantially less than that of control ( or = 0.43 , 95% ci = 0.28 , 0.66 , p = 0.0001 ).Conclusion.In conclusion, the current meta-analysis shows that bifidobacterium quadruple viable bacterium combined with mesalamine has a satisfactory effect in the treatment of uc in china, and its safety is better than that of mesalamine or bifidobacterium quadruple viable bacteria alone.However, randomized controlled trials with standardized designs and large sample sizes are still needed for further validation.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Meta-Analysis;Review Article;
Effects of miR-363 on the Biological Activities of Eutopic Endometrial Stromal Cells in Endometriosis

Ems is a kind of benign disease with certain malignant behaviors.The adhesion, invasive growth, and angiogenesis of ectopic endometrial cells are the pathological basis of ems occurrence, but its etiology and pathogenesis have not been completely illustrated yet.In our research, we aim to investigate the role of mi r‐363 in the pathogenesis of endometriosis.Real‐time quantitative pcr was used to detect the expression of mi r‐363 before and after esc/nsc transfection.Cck‐8, flow cytometry, and transwell assay were used to detect the effect of the mi r‐363 expression on cell proliferation, apoptosis, and invasion.The effects of the mi r‐363 expression on the contents of fas/apo‐1 and icam‐1 in cell culture supernatant were detected by elisa.Q rt‐pcr and wb assay were used to detect the effects of the mi r‐363 expression on the m rna and protein expression levels of icam‐1, mmp‐7, and vegf in esc.The increased expression of mi r‐363 could inhibit the proliferation and invasion of esc, promote apoptosis, and inhibit the secretion of fas/apo‐1 and icam‐1.The knockdown expression of mi r‐363 promoted proliferation and invasion of nsc, inhibited apoptosis, and promoted secretion of fas/apo‐1 and icam‐1.Vcam‐1, vegf, and mmp‐7 were detected in escs before transfection.The protein expression level was higher than that of nscs.Compared with pretransfection, the protein levels of vcam‐1, vegf, and mmp‐7 in the m‐363 group were significantly downregulated.The downregulated expression of mi r‐363 was associated with a stronger cell proliferation ability, a lower cell apoptosis rate, and a stronger esc.Migration is associated with invasiveness, proliferation, angiogenesis, and immune escape.The low expression of mi r‐363 promotes endogenesis through posttranscriptional regulation of target genes vcam‐1, mmp‐7, and vegf.The differential expression of mi r‐363 between esc and nsc may be an important factor in the many biological differences between esc and nsc.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Effects of Cardiac Rehabilitation on Cardiac Function and Quality of Life in Patients with Ischemic Nonobstructive Coronary Artery Disease and Diabetes Mellitus

To investigate the effect of cardiac rehabilitation on the quality of life in patients with ischemic and nonobstructive coronary artery disease complicated with diabetes mellitus.Methods .From january 2020 to june 2021, 100 patients with ischemic nonobstructive coronary heart disease complicated with diabetes were randomly divided into the control group ( n = 50).The routine drug therapy observation group (50 cases) was treated with routine drugs combined with cardiac rehabilitation at 6 months for 1 course.The curative effect, cardiac function, 6 min walking distance (6mwd), cardiopulmonary exercise test (cpft) index, sf‐36 health status survey scale, and quality of life score were compared between the two groups.Results .The total effective rate of the observation group was significantly higher than that of the control group ( p &lt; 0.05).After treatment, there was no significant change in cardiac function and 6mwd in the control group.The left ventricular ejection fraction and 6mwd in the observation group were significantly higher/longer than those before treatment and the control group (all p &lt; 0.05).After treatment, the indexes of cpet in the two groups were improved in varying degrees.The forced vital capacity and oxygen uptake of anaerobic valve in the observation group were significantly higher than those in the control group (all p &lt; 0.05).After treatment, the scores of the sf‐36 in both groups were improved in varying degrees.The physiological function, general health, energy, mental health, and total scores of the observation group were significantly higher than those of the control group (all p &lt; 0.05).Conclusion .Cardiac rehabilitation can significantly improve the cardiorespiratory function, exercise ability, and quality of life in patients with ischemic and nonobstructive coronary artery disease complicated with diabetes mellitus.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Effects of Acupuncture Combined with Biofeedback Therapy on Limb Motor Rehabilitation in Patients with Acute Stroke: Systematic Review and Meta-Analysis

The purpose of the systematic review is to verify the effect of biofeedback therapy on limb motor rehabilitation in patients with acute stroke and to provide evidence‐based medicine for the promotion and use of biofeedback therapy.Methods .The randomized controlled trials (rct) of biofeedback therapy in the treatment of cerebral palsy were searched in pub med, embase, science direct, cochrane library, china national knowledge infrastructure (cnki), china vip database, wanfang database, and chinese biomedical literature database (cbm).The starting time and ending time of this study are from the time of building the database of the number of pieces to october 31, 2018.The data included in this study were extracted by two independent researchers and evaluated the bias risk of all the literature included in the study according to the cochrane manual 5.1.0 criteria.Rev man5.4 statistical software was used to analyze the collected data by meta.Results .This systematic review included 9 rct studies with a total of 1410 patients.The results of meta‐analysis showed that there were significant differences in the improvement of lower limb muscle tension, comprehensive spasm scale score, emg score, and passive range of motion of ankle joint between biofeedback therapy and routine rehabilitation therapy.Conclusion .Biofeedback therapy can improve lower limb muscle tension, spasticity, emg integral value, and passive range of motion of ankle joint in children with cerebral palsy and provide better conditions for improving the motor ability of lower extremities in children with cerebral palsy.However, more studies and follow‐up with higher methodological quality and longer intervention time are needed to further verify.

Journal: BioMed Research International (2022)
Publication types: Meta-Analysis;
Effect of TGF-β2 on the Mechanical Properties of Posterior Scleral Fibroblasts in Experimental Myopia

The effects of tgf‐ β 2 on mechanical properties of sclerotic desmocytes isolated from healthy and myopic guinea pigs were investigated in order to further understand the pathogenesis of myopia.To study the effect of tgf‐ β 2 on the mechanical properties of posterior scleral fibroblasts in experimental myopia.Methods .A lens‐induced myopia (lim) animal model was developed in 12 guinea pigs, with the opposite eye serving as a self‐control (sc).Five untreated guinea pigs served as normal controls.Lenses were removed 30 days after model onset.Primary scleral fibroblasts were isolated and passaged twice and then treated with vehicle control or 1, 10, or 100 ng/m l tgf‐ β 2.After 24 h, micropipette aspiration was used to investigate the viscoelastic properties of the cells.Results .Scleral fibroblasts from lim exhibited significantly higher equilibrium moduli and apparent viscosities relative to sc without tgf‐ β 2 treatment.Treatment of lim or sc scleral fibroblasts with 1 or 10 ng/m l tgf‐ β 2 led to significantly different ( p &lt; 0.05) equilibrium moduli and apparent viscosities compared with vehicle control, whereas no significant differences were observed upon treatment with 100 ng/m l tgf‐ β 2.Lim cells treated with 1 and 10 ng/m l tgf‐ β 2 exhibited lower equilibrium moduli and apparent viscosities compared with similarly treated sc cells, but lim cells and sc cells treated with 100 ng/m l tgf‐ β 2 had similar mechanical properties.Conclusions .The addition of 1 and 10 ng/m l tgf‐ β 2 can lower the equilibrium modulus and apparent viscosity of scleral fibroblasts in the normal eye.

Journal: BioMed Research International (2022)
Publication types: Research Article;
DNA Methyltransferase Inhibitor 5-AZA-DC Regulates TGFβ1-Mediated Alteration of Neuroglial Cell Functions after Oxidative Stress

5-aza-dc is an efficient methylation inhibitor that inhibits methylation of target dna.In this study, we explored the effects of 5-aza-dc on the regulation of tgfβ1 on target genes in neuroglial cell, as well as neuroglial cell functions under oxidative stress.The oxidative stress was constructed by editing crispr/cas9 for knock out ang-1 and apo e4 genes.Cells were subjected to tgfβ1oe (or sh tgfβ1) transfection and/or 5-aza-dc intervention.Results showed that under oxidative stress, both tgfβ1oe and sh tgfβ1 transfection raised dnmt1, but reduced tgfβ1, pten, and tsc2 expressions in neuroglial cells.Tgfβ1 directly bind to the promoter of pten gene.5-aza-dc intervention lowered dnmt1 and raised tgfβ1 expression, as well as promoted the binding between tgfβ1 and promoter of pten.Tgfβ1oe caused a significant increase in the dna demethylation level of pten promoter, while 5-aza-dc intervention reduced the dna demethylation level of pten promoter.Under oxidative stress, tgfβ1oe (or sh tgfβ1) transfection inhibited neuroglial cell proliferation, migration, and invasion, promoted cell apoptosis.5-aza-dc intervention alleviated tgfβ1oe (or sh tgfβ1) transfection caused neuroglial cell proliferation, migration, and invasion inhibition, as well as cell apoptosis.To conclude, these results suggest that 5-aza-dc can be used as a potential drug for epigenetic therapy on oxidative stress damage in neuroglial cells.The findings of this research provide theoretical basis and research ideas for methylation drug intervention and tgfβ1 gene as a possible precise target of glial oxidative stress diagnosis and treatment.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Effects of Caffeine Intake on Cardiopulmonary Variables and QT Interval after a Moderate-Intensity Aerobic Exercise in Healthy Adults: A Randomized Controlled Trial

Caffeine is considered a widely consumed natural and legal psychoactive stimulant with several effects on the body.The present study attempted to investigate the effects of caffeine consumed before and after a physical exercise on cardiovascular and cardiorespiratory functions in healthy adults.36 healthy adult males were recruited and randomly allocated to one of the three (3) groups: group i (exercise without caffeine consumption), group ii (caffeine beverage intake before exercise), and group iii (caffeine beverage intake immediately after exercise).The heart rate (hr), qtc interval, blood pressure (bp), respiratory rate (rr), oxygen consumption (vo2), and carbon dioxide emission (vco2) were measured at 0, 5, 10, and 15 min after the exercise.We observed a significant difference in all measured outcomes during the different recovery times in all the groups ( p &lt; 0.05).Hr, rr, sbp, vo 2 , and vco 2 gradually decreased with time, dbp contrarily increased with time, and the qtc showed an irregular pattern.We can affirm that ingestion of caffeine before and after moderate aerobic exercise slows down the parasympathetic stimulation, heart rate recovery, and the recovery of hr and qtc with no major effects on bp, rr, vo2, and vco2 in healthy adult men.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Effectiveness of Yoga on the Interrectus Distance in Early Postpartum Women: A High-Frequency Ultrasound Study

To investigate the effects of ultrasonic evaluation of a progressive yoga exercise program on reducing the inter‐recti distance (ird) among women in the early postpartum period.Postpartum women ( n = 116), free of obstetric complications and in recovery following vaginal delivery between weeks 1 and 12, were recruited.Participants were randomly assigned to the control and yoga exercise group in the pre‐ and post‐intervention design.The control group received no treatment, while the yoga exercise group participated in a guided 12‐week progressive yoga exercise program started at postpartum week 1.The ird was examined using high‐frequency ultrasound at postpartum weeks 6 and 12.The results showed that the supraumbilical, umbilical, and subumbilical ird were significantly decreased in the yoga exercise group after the 12‐week progressive yoga exercise intervention compared with the first (week 6) and second (week 12) measurements.The differences in ird at supraumbilical, umbilical, and subumbilical intervals between weeks 6 and 12 significantly increased in the yoga exercise group.Progressive yoga exercises are effective program that reduce ird among women in the early postpartum period through ultrasound evaluation.In conclusion, women should advocate combined yoga exercise in the early postpartum days following a supervised program.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Effect of Simultaneous Multiplane Surgery on Cardiopulmonary Function in Patients with Moderate to Severe Obstructive Sleep Apnea-Hypopnea Syndrome and Its Curative Effect

To investigate the changes in cardiopulmonary function in patients with obstructive sleep apnea‐hypopnea syndrome (osahs) by one‐stage multiplane surgery.Methods .70 patients with moderate and severe osahs underwent nasal in our hospital from july 2017 to february 2021, palatopharyngeal, and/or tongue operations simultaneously and were followed up for 6 months.The epworth sleeping scale (ess) scores of patients before and after surgery were compared to observe the surgical efficacy, and the changes in the cardiopulmonary function of patients before and after surgery were detected.The static and dynamic indexes of cardiopulmonary function, respiratory disturbance index (ahi), and blood oxygen saturation (sa o 2 ) were compared before and after the operation.Results .After surgery, all patients’ indexes of static lung function were improved compared with that before surgery.After surgery, the percentage of maximal oxygen uptake peak to the predicted value, percentage of oxygen pulse to the predicted value, the ratio of oxygen uptake power, anaerobic threshold, and maximum ventilatory capacity per minute/maximum exercise volume were increased compared with that before surgery, and ahi and sa o 2 were improved compared with that before surgery.Conclusion .This study suggests that it is feasible for patients with osahs who are unable to tolerate or unwilling to undergo noninvasive assisted ventilation to undergo simultaneous surgery for multiplane stenosis.It can reduce clinical symptoms and improve cardiopulmonary function.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Effect of Recombinant Netrin-1 Protein Combined with Peripheral Blood Mesenchymal Stem Cells on Angiogenesis in Rats with Arteriosclerosis Obliterans

This work was aimed to explore the effect of recombinant netrin‐1 protein and peripheral blood mesenchymal stem cells (mscs) on the angiogenesis ability of atherosclerosis.28 sprague dawley (sd) rats were taken as research models.The arterial occlusion models were created by surgery and then divided into the saline control group ( n =7), netrin‐1 treatment group ( n =7), mscs treatment group ( n =7), and netrin‐1 + mscs combined treatment group ( n =7).The peripheral blood mscs were extracted from the peritoneal cavity of diseased sd rats and cultured alone or in combination with netrin‐1.The individually cultured mscs and netrin‐1 were locally injected into the ischemic tissues of sd rats.The tarlov scoring was performed at the first, second, and third week of treatment, respectively.The expression of vascular endothelial growth factor (vegf) was also measured by quantitative real‐time polymerase chain reaction (q rt‐pcr), and the capillary density was measured by immunofluorescence staining.The mean maximum contractility of the gastrocnemius muscle in each group was determined in the third week after treatment.The tarlov score of the netrin‐1 + mscs group was significantly higher than that of the control group ( p &lt; 0.05) at the second week.To the 4th week of treatment, the tarlov score of the netrin‐1 + mscs group was highly increased compared to the netrin‐1 group and the mscs group ( p &lt; 0.05).The expression of vegf in the treatment groups was greatly increased each week compared to the control group ( p &lt; 0.05).Compared with the netrin‐1 and the mscs groups, the vegf was also notably increased in the netrin‐1 + mscs group ( p &lt;0.05).The capillary densities of the treatment groups were observably greater than that of the control group in the second and third weeks ( p &lt;0.05), while the capillary density in the netrin‐1 + mscs group was also significantly increased than those in the netrin‐1 group and the mscs group ( p &lt; 0.05).The mean maximum contractility of the netrin‐1 + mscs group was remarkably higher than that of the other groups ( p &lt; 0.05).The netrin‐1 + mscs group achieved the higher tarlov score, higher vegf expression, higher capillary density, and better muscle recovery than netrin‐1 and mscs treatments.

Journal: BioMed Research International (2022)
Publication types: Research Article;