syedzayyan/paper_mill_benchmark huggingface dataset:
Effect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial.

Importance for patients with large vessel occlusion strokes, it is unknown whether endovascular treatment alone compared with intravenous thrombolysis plus endovascular treatment (standard treatment) can achieve similar functional outcomes.Objective to investigate whether endovascular thrombectomy alone is noninferior to intravenous alteplase followed by endovascular thrombectomy for achieving functional independence at 90 days among patients with large vessel occlusion stroke.Design, setting, and participants multicenter, randomized, noninferiority trial conducted at 33 stroke centers in china.Patients (n = 234) were 18 years or older with proximal anterior circulation intracranial occlusion strokes within 4.5 hours from symptoms onset and eligible for intravenous thrombolysis.Enrollment took place from may 20, 2018, to may 2, 2020.Patients were enrolled and followed up for 90 days (final follow-up was july 22, 2020).Interventions a total of 116 patients were randomized to the endovascular thrombectomy alone group and 118 patients to combined intravenous thrombolysis and endovascular thrombectomy group.Main outcomes and measures the primary end point was the proportion of patients achieving functional independence at 90 days (defined as score 0-2 on the modified rankin scale; range, 0 [no symptoms] to 6 [death]).The noninferiority margin was -10%.Safety outcomes included the incidence of symptomatic intracerebral hemorrhage within 48 hours and 90-day mortality.Results the trial was stopped early because of efficacy when 234 of a planned 970 patients had undergone randomization.All 234 patients who were randomized (mean age, 68 years; 102 women [43.6%]) completed the trial.At the 90-day follow-up, 63 patients (54.3%) in the endovascular thrombectomy alone group vs 55 (46.6%) in the combined treatment group achieved functional independence at the 90-day follow-up (difference, 7.7%, 1-sided 97.5% ci, -5.1% to ∞)p for noninferiority = .003).No significant between-group differences were detected in symptomatic intracerebral hemorrhage (6.1% vs 6.8%; difference, -0.8%; 95% ci, -7.1% to 5.6%) and 90-day mortality (17.2% vs 17.8%; difference, -0.5%; 95% ci, -10.3% to 9.2%).Conclusions and relevance among patients with ischemic stroke due to proximal anterior circulation occlusion within 4.5 hours from onset, endovascular treatment alone, compared with intravenous alteplase plus endovascular treatment, met the prespecified statistical threshold for noninferiority for the outcome of 90-day functional independence.These findings should be interpreted in the context of the clinical acceptability of the selected noninferiority threshold.Trial registration chinese clinical trial registry: chi ctr-ior-17013568.

Journal: JAMA (2021)
Publication types: Comparative Study;Equivalence Trial;Journal Article;Multicenter Study;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
The efficacy of continuing nursing interventions on intraoperative pressure ulcer-related complications in breast cancer patients: systematic review and meta-analysis.

This study systematically reviewed the effects of continuous nursing intervention on intraoperative pressure ulcers (pus) and related complications in breast cancer patients.The effectiveness of continuous nursing intervention for intraoperative pressure ulcers related complications in breast cancer patients is highly controversial.Therefore, it is necessary to systematically review and address this issue by means of meta-analysis.Methods by searching the cochrane library, pub med, web of science, embase, and chinese biomedical literature database (cbm) were screened.Quality evaluation and data extraction were performed for the included studies, and meta-analysis was performed for the included rcts using review manager 5.2 software.Literature was included in strict compliance with the picos principle, and bias risk was analyzed byt-test and funnel plot.Results a total of 1,431 patients were enrolled in 9 studies, and meta-analysis showed that there was a significant statistical difference between the experimental group and the control group in the incidence of pus [odds ratio (or) =0.18, 95% confidence interval (95% ci): 0.13-0.24, p<0.00001], the braden pressure ulcer risk score after nursing [mean difference (md) =2.64, 95% ci: 1.47-3.81, p<0.0001], and the quality of life after nursing (md =9.76, 95% ci: 6.82-12.69, p<0.00001).Discussion continuous care can reduce the incidence of pus in patients with advanced breast cancer, reduce the severity of wounds in the healing process of pus, and improve the knowledge of pus in patients with advanced breast cancer risk.

Journal: Gland surgery (2022)
Publication types: Journal Article
TGFβ Is Specifically Upregulated on Circulating CD14++ CD16+ and CD14+ CD16++ Monocytes in Patients with Atrial Fibrillation and Severe Atrial Fibrosis.

Fibrotic remodeling of the atria plays a key role in the pathogenesis of atrial fibrillation (af).As little is known about the contribution of circulating monocytes in atrial remodeling and the pathophysiology of af, we investigated profibrotic factors in different subsets of circulating monocytes obtained from patients with atrial fibrillation undergoing catheter ablation.Methods a 3d high density voltage mapping was performed in sinus rhythm to evaluate the extent of low-voltage areas (lvas) in the atria of 71 patients with persistent af.Low-voltage was defined as signals of < 0.5m v during sinus rhythm.Prior to ablation, blood was drawn and monocytes were analyzed by facs.Based on the expression of cd14 and cd16, three subgroups including cd14++ cd16- ('classical'), cd14++ cd16+ ('intermediate'), and cd14+ cd16++ ('non-classical') were analyzed for the expression of tgfb, cd147, and mmp-9, representing pivotal profibrotic pathways in myocardial remodeling.Results expression of tgfb was increased in cd14+ monocytes of patients with extensive lvas compared to patients with a low extend of lvas.While cd14++ cd16- monocytes showed no difference, cd14++ cd16+ and cd14+ cd16++ monocytes showed a strong increase of tgfb abundance.Although cd147 and mmp-9 are strongly associated with myocardial fibrosis, we found no difference in expression between the two groups in any monocyte subsets.Conclusion tgfb is specifically upregulated on cd14++ cd16+ and cd14+ cd16++ monocytes in patients with extensive lvas undergoing catheter ablation.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (2018)
Publication types: Journal Article
Applications of Polymeric Membranes with Carbon Nanotubes: A Review.

Nanomaterials have been commonly employed to enhance the performance of polymeric membrane materials that are used in several industrial applications.Carbon nanotubes (cnts) have gained notable attention over the years for use in membrane technology due to their anti-biofouling properties, salt rejection capability, exceptional electrical conductivity, and mechanical properties.This paper aims to discuss some of the recent applications of cnts in membrane technology and their effect on a larger scale.The paper reviews successful case studies of incorporation of cnts in membranes and their impact on water purification, desalination, gas separations, and energy storage, in an effort to provide a better understanding of their capabilities.Regarding the future trends of this technology, this review emphasizes improving the large-scale production processes and addressing environmental and health-related hazards of cnts during production and usage.

Journal: Membranes (2022)
Publication types: Journal Article;Review
Should We Prolong the Observation Period for Neurological Recovery After Cardiac Arrest?

S to evaluate whether the recommended observation period of 7 days for cardiac arrest survivors is sufficient for conscious recovery and to identify the variables associated with eventual neurologic recovery among patients with delayed awakening.Design a retrospective cohort study.Setting a single tertiary medical center.Patients five-hundred twenty-nine nontraumatic adult cardiac arrest survivors with prearrest favorable neurologic function (cerebral performance category 1-2) who survived to hospital discharge during 2011-2019.Interventions the enrolled patients were classified into favorable (cerebral performance category 1-2) and poor (cerebral performance category 3-4) neurologic recovery according to their neurologic function at hospital discharge.Among patients with favorable neurologic recovery, those who recovered within 7 days were assigned to the early recovery group or after 7 days as the late recovery group.Measurements and main results there were 395 patients exhibiting favorable neurologic recovery (n = 357 in the early group, n = 38 in late group) and 134 patients exhibiting poor neurologic recovery (poor recovery group).Among patients who remained unconscious on day 7, delayed awakening was associated with male sex (odds ratio [or], 3.905; 95% ci, 1.153-13.221), prehospital return of spontaneous circulation (or, 7.628; 95% ci, 2.084-27.922), therapeutic hypothermia (or, 4.320; 95% ci, 1.624-11.488), and extracorporeal cardiopulmonary resuscitation (or, 4.508; 95% ci, 1.414-14.371).Being transferred from another hospital, however, was less likely to be associated with delayed awakening (or, 0.061; 95% ci, 0.009-0.431).The median duration for patients to regain clear consciousness in the late recovery group was 12.12 days.No patient who recovered consciousness had an unfavorable electroencephalography pattern, however, in patients with poor recovery, the 7-day electroencephalography showed 45 patients with generalized suppression (33.6%), two with burst suppression (1.5%), 14 with seizure/epileptic discharge (10.5%), and one with status epilepticus (0.7%).Conclusions up to 9.6% of cardiac arrest patients with favorable outcomes recover consciousness after the recommended 7 days of observation, indicating the observation time of 7 days seems justified but longer duration may be needed.The results of the culturally and clinically isolated population may limit the application to other population.

Journal: Critical care medicine (2022)
Publication types: Journal Article
Early relapse rate determines further relapse risk: results of a 5-year follow-up study on pediatric CFH-Ab HUS.

The complement factor h antibody (cfh-ab)-associated hemolytic uremic syndrome (hus) forms a distinct subgroup within the complement-mediated hus disease spectrum.The autoimmune nature of this hus subgroup implies the potential benefit of a targeted immunosuppressive therapy.Data on long-term outcome are scarce.Methods this observational study evaluates the clinical outcome of 19 pediatric cfh-ab hus patients from disease onset until their 5-year follow-up.Results all but one relapse occurred during the first 2 years, and patients who had no relapse within the first 6 months were relapse-free until the end of the observation period.Kidney function at disease onset determines long-term kidney function: all individuals with normal kidney function at disease onset had normal kidney function after 5 years, and all patients with reduced kidney function at onset had impaired kidney function at the last follow-up.Level of cfh-ab titer at disease onset was not correlated with a higher risk of recurrences or worse long-term outcome after 5 years.Resolution of cfh-ab titers after 5 years was common.Conclusions cfh-ab hus patients have a varied overall long-term course.Early relapses are common, making close surveillance during the first years essential, regardless of the initial cfh-ab titer.

Journal: Pediatric nephrology (Berlin, Germany) (2021)
Publication types: Journal Article;Observational Study;Research Support, Non-U.S. Gov't
Effects of a Constant Magnetic Field on the Electrochemical Reactions of Quercetin.

The paper presents a study of the effect of a constant magnetic field (cmf) on the basic processes of quercetin electrochemical reactions.According to the observation made in previous studies, the presence of a double bond in the c-ring of quercetin enhances the antioxidant properties of that compound, whereas the presence of -oh groups also affects the antioxidant properties.Using cyclic voltammetry it was found that the constant magnetic field improves the efficiency of quercetin electrooxidation, especially of the third stage of the process, i.E.The stage in which the oxidation of the oh groups in the a-ring is the most difficult.The use of hplc confirmed the electrochemical measurements and the results of cyclic voltammetry studies.The beneficial effect of the magnetic field on the efficiency of quercetin oxidation was confirmed by the results of impedance spectroscopy measurements.

Journal: ChemistryOpen (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The effects of acute Cannabis smoke or Δ9-THC injections on the trial-unique, nonmatching-to-location and five-choice serial reaction time tasks in male Long-Evans rats.

Executive functions including working memory (wm) and attention are altered following cannabis exposure in humans.To test for similar effects in a rodent model, we exposed adult male rats to acute cannabis smoke before testing them on touchscreen-based tasks that assess these executive processes.The trial-unique, delayed nonmatching-to-location (tunl) task was used to evaluate wm, task performance at different spatial pattern separations, and response latencies.The five-choice serial reaction time task (5-csrtt) was used to measure attention, impulsivity, perseveration, and response latencies.Rats were exposed acutely to high- δ9-tetrahydrocannabinol (thc), low-cbd (mohawk) and low-thc, high-cbd (treasure island) strains of cannabis smoke using a chamber inhalation system.The effects of cannabis smoke were directly compared to systemic δ9-thc injection (3.0 mg/kg; i.p.).Tunl task performance was significantly impaired following acute high-thc smoke exposure or thc injections, but not low-thc smoke exposure, with no effects on response latencies.Fewer total trials and selection trials were also performed following thc injections.Performance was poorer for smaller separation distances in all groups.Neither acute smoke exposure, nor injected thc, impacted attentional processes, impulsivity, perseverations, or response latencies in the 5-csrtt.Pharmacokinetic analysis of rat plasma revealed significantly higher thc levels following injections than smoke exposure 30 min following treatment.Exposure to low-thc, high-cbd cannabis smoke significantly increased cbd in plasma, relative to the other treatments.Taken together, our results suggest that wm processes as measured by the tunl task are more sensitive to thc exposure than the attentional and impulsivity measures assessed using the 5-csrtt.

Journal: Neurobiology of learning and memory (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Risk factors for child stunting in Bangladesh: an analysis using MICS 2019 data.

Malnutrition is considered a major public health challenge and is associated with a range of health issues, including childhood stunting.Stunting is a reliable and well-recognized indicator of chronic childhood malnutrition.The objective of this study is to determine the risk factors associated with stunting among 17,490 children below five years of age in bangladesh.Methods correlates of child stunting were examined using data generated by a cross-sectional cluster survey conducted in bangladesh in 2019.The data includes a total of 17,490 children (aged < 5 years) from 64,400 households.Multiple logistic regressions were used to determine the risk factors associated with child stunting and severe stunting.Results the prevalence of stunting and severe stunting for children was 25.96% and 7.97%, respectively.Children aged 24 to < 36 months [odds ratio (or) = 2.65, 95% ci: 2.30, 3.05] and aged 36 to < 48 months [or = 2.33, 95% ci: 2.02, 2.69] had more risk of stunting compared to the children aged < 6 months.Children from sylhet division had the greatest risk of stunting of all the eight divisions [or = 1.26, 95% ci: 1.09, 1.46].Children of secondary complete or higher educated mothers were less likely to develop stunting [or = 0.66, 95% ci: 0.56, 0.79] compared with children of mothers having no education at all.Similarly, children of secondary complete or higher educated father [or = 0.74, 95% ci: 0.63, 0.87] were found to have lower risk of stunting compared with children whose father hadn't any education.Substantially lower risk of stunting was observed among children whose mother and father both completed secondary education or above [or = 0.59, 95% ci: 0.52, 0.69].Children from the richest households [or = 0.49, 95% ci: 0.41, 0.58] had 51% lower odds of stunting compared to children from the poorest households.Conclusions after controlling for socioeconomic and demographic factors, parental education and household position in the wealth index were found to be the most important determinants of child stunting in bangladesh.

Journal: Archives of public health = Archives belges de sante publique (2022)
Publication types: Journal Article
Master's Prepared Clinical Nurse Leaders: 2 to 10 Years Post-Graduation.

Because the clinical nurse leader (cnl) role is relatively new, little is known about the success of cnl graduates.Our aim was to describe the career path of cnl graduates and to measure satisfaction 2 to 10 years after graduation.Methods a cross-sectional survey design was used to assess career trajectory and self-reported satisfaction with work, life, and educational preparation in a sample of 109 cnl graduates from one university.Online data collection was used, resulting in participants from across the united states.Results respondents were primarily direct entry cnl graduates.The majority (95%) were still working full- or part-time in nursing.Most (over 90%) were satisfied or extremely satisfied with their decision to become a nurse.Life satisfaction was high: the satisfaction with life scale mean score was 24.9 (sd = 5.67).Conclusion these results help describe cnl career trajectories and provide useful suggestions for education and practice.This information can help build the business case for the cnl.

Journal: Journal of nursing care quality (2022)
Publication types: Journal Article
Ventilator-Associated Pneumonia Due to MRSA vs. MSSA: What Should Guide Empiric Therapy?

The guidelines on ventilator-associated pneumonia (vap) recommend an empiric therapy against methicillin-resistant staphylococcus aureus(mrsa) according to its prevalence rate.Considering the mrsa and mssa vap prevalence over the last 9 years in our tertiary care hospital, we assessed the clinical value of the mrsa nasal-swab screening in either predicting or ruling out mrsa vap.We extracted the data of 1461 patients with positive bronchoalveolar lavage (bal).Regarding the mrsa nasal-swab screening, 170 patients were positive for mrsa or mssa.Overall, mrsa had a high prevalence in our icu.Despite the covid-19 pandemic, there was a significant downward trend in mrsa prevalence, while mssa remained steady over time.Having vap due to mrsa did not have any impact on los and mortality.Finally, the mrsa nasal-swab testing demonstrated a very high negative predictive value for mrsa vap.Our results suggested the potential value of a patient-centered approach to improve antibiotic stewardship.

Journal: Antibiotics (Basel, Switzerland) (2022)
Publication types: Journal Article
OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: Oxidative stress in polycystic ovary syndrome.

In brief a genetic, epigenetic, and environmental association exists between oxidative stress (os) and polycystic ovary syndrome (pcos), expressed in a multifaceted clinical profile.This review summarizes and discusses the role of os in the pathogenesis of pcos syndrome, focusing on metabolic, reproductive, and cancer complications.Abstract oxidative stress (os), an imbalance between oxidants and antioxidants in cells, is one of many factors playing essential roles in the pathogenesis of polycystic ovary syndrome (pcos).Pcos is described mainly as a disproportion of reproductive hormones, leading to chronic anovulation and infertility in women.Interestingly, os in pcos may be associated with many disorders and diseases.This review focuses on characteristic markers of os in pcos and the relationship between os and pcos related to insulin resistance (ir), hyperandrogenemia, obesity, chronic inflammation, cardiovascular diseases, and cancer.Interestingly, in patients with pcos, an increase in oxidative status and insufficient compensation of the increase in antioxidant status before any cardiovascular complications are observed.Moreover, free radicals promote carcinogenesis in pcos patients.However, despite these data, it has not been established whether oxygen stress influences pcos development or a secondary disorder resulting from hyperglycemia, ir, and cardiovascular and cancer complications in women.

Journal: Reproduction (Cambridge, England) (2022)
Publication types: Review;Journal Article
Incorporating Genome-Wide Association Mapping Results Into Genomic Prediction Models for Grain Yield and Yield Stability in CIMMYT Spring Bread Wheat.

Untangling the genetic architecture of grain yield (gy) and yield stability is an important determining factor to optimize genomics-assisted selection strategies in wheat.We conducted in-depth investigation on the above using a large set of advanced bread wheat lines (4,302), which were genotyped with genotyping-by-sequencing markers and phenotyped under contrasting (irrigated and stress) environments.Haplotypes-based genome-wide-association study (gwas) identified 58 associations with gy and 15 with superiority index pi(measure of stability).Sixteen associations with gy were "environment-specific" with two on chromosomes 3b and 6b with the large effects and 8 associations were consistent across environments and trials.For pi, 8 associations were from chromosomes 4b and 7b, indicating 'hot spot' regions for stability.Epistatic interactions contributed to an additional 5-9% variation on average.We further explored whether integrating consistent and robust associations identified in gwas as fixed effects in prediction models improves prediction accuracy.For gy, the model accounting for the haplotype-based gwas loci as fixed effects led to up to 9-10% increase in prediction accuracy, whereas for pithis approach did not provide any advantage.This is the first report of integrating genetic architecture of gy and yield stability into prediction models in wheat.

Journal: Frontiers in plant science (2020)
Publication types: Journal Article
The role of biglycan in the healthy and thoracic aneurysmal aorta.

The class i small leucine-rich proteoglycan biglycan is a crucial structural extracellular matrix component that interacts with a wide range of extracellular matrix molecules.In addition, biglycan is involved in sequestering growth factors such as transforming growth factor-β and bone morphogenetic proteins and thereby regulating pathway activity.Biglycan consists of a 42-k da core protein linked to two glycosaminoglycan side chains and both are involved in protein interactions.Biglycan is encoded by the bgngene located on the x-chromosome and is expressed in various tissues, including vascular tissue, skin, brain, kidney, lung, the immune system, and the musculoskeletal system.Although an increasing amount of data on the biological function of biglycan in the vasculature has been produced, its role in thoracic aortic aneurysms is still not fully elucidated.This review focuses on the role of biglycan in the healthy thoracic aorta and the development of thoracic aortic aneurysm and dissections in both mice and humans.

Journal: American journal of physiology. Cell physiology (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't