syedzayyan/paper_mill_benchmark huggingface dataset:
Ecological stoichiometry influences phytoplankton alpha and beta diversity rather than the community stability in subtropical bay.

Numerous studies have shown that changes in environmental factors can significantly impact and shift the structure of phytoplankton communities in marine ecosystems.However, little is known about the association between the ecological stoichiometry of seawater nutrients and phytoplankton community diversity and stability in subtropical bays.Therefore, we investigated the relationship between the phytoplankton community assemblage and seasonal variation in the beibu gulf, south china sea.In this study, we found that the abundance of bacillariophyceae in spring was relatively greater than in other seasons, whereas the abundance of coscinodiscophyceae was relatively low in spring and winter but greatly increased in summer and autumn.Values of the alpha diversity indices gradually increased from spring to winter, revealing that seasonal variations shifted the phytoplankton community structure.The regression lines between the average variation degree and the shannon index and bray-curtis dissimilarity values showed significantly positive correlations, indicating that high diversity was beneficial to maintaining community stability.In addition, the ecological stoichiometry of nutrients exhibited significantly positive associations with shannon index and bray-curtis dissimilarity, demonstrating that ecological stoichiometry can significantly influence the alpha and beta diversity of phytoplankton communities.The c:n:p ratio was not statistically significantly correlated with average variation degree, suggesting that ecological stoichiometry rarely impacted the community stability.Temperature, nitrate, dissolved inorganic phosphorous, and total dissolved phosphorus were the main drivers of the phytoplankton community assemblage.The results of this study provide new perspectives about what influences phytoplankton community structure and the association between ecological stoichiometry, community diversity, and stability in response to environmental changes.

Journal: Ecology and evolution (2022)
Publication types: Journal Article
Vasculitis Secondary to Pulmonary Bacterial Infection: A Case Report.

Vasculitides are a heterogeneous group of primary disorders which may occur secondary to a variety of conditions.Among them, vasculitis caused by bacterial infection is rare.Here, we present images of ct scans and histology from a 22-year-old young chinese man with vasculitis secondary to bacterial infection, which is a difficult disease to diagnose.This patient had been diagnosed with antineutrophil-cytoplasmic-antibody-negative vasculitis with pulmonary and renal involvement and was treated with glucocorticoids combined with immunosuppressive agents.However, during his follow up we found that multiple patchy shadows and cavities in both lungs and renal lesions had fluctuated, and the improvement of chest imaging was always related to antibiotic treatment.In addition, renal histology showed capillary loop necrosis and extensive crescent formation, and electron microscopy revealed scattered subepithelial hump-like deposits, which favored the diagnosis of infection over idiopathic vasculitis.Therefore, vasculitis secondary to infection was confirmed.The subsequent therapy response supported our diagnosis.This case is important; since vasculitis secondary to infection is uncommon, our case provides a model for the diagnosis of vasculitis secondary to infection.

Journal: Diagnostics (Basel, Switzerland) (2022)
Publication types: Case Reports;Journal Article
Catalytic Pyrolysis of Sawdust with Desulfurized Fly Ash for Pyrolysis Gas Upgrading.

In this study, the catalytic effects of desulfurized fly ash (dfa) on the gaseous products of sawdust (sd) pyrolysis were investigated in a tubular furnace.The results indicated that dfa catalyzed the process of sd decomposition to improve the hydrogen content and the calorific value of pyrolysis gas.As to its effect on pyrolysis products, dfa increased the non-oxide content of ch4, c3h4, and h2in pyrolysis gas by 1.4-, 1.8-, and 2.3-fold, respectively.Meanwhile, the catalytic effect of dfa reduced the co and co2yields during dfa/sd pyrolysis.Based on the model compound method, ca so3and ca(oh)2in dfa was proved to have quite different catalytic effects on pyrolysis gas components.Ca(oh)2accelerated the formation of ch4and h2through the cracking of methoxyl during lignin and cellulose degradation, while ca so3favored the generation of co and co2due to the carbonyl and carboxyl of lignin in sd.Ca so3also catalyzed sd pyrolysis to promote the c3h4yield in pyrolysis gas.Overall, the catalytic pyrolysis of sd with dfa yielded negative-carbon emission, which upgraded the quality of the pyrolysis gas.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Shared positive emotion during parent-toddler play and parent and child well-being in Mexican origin families.

The present study aimed to examine the association between mother-child and father-child shared positive emotion and parent self-reported parenting stress, as well as parent rated child socio-emotional adjustment.Method data were collected from 107 mexican origin families with a toddler age child (m = 17.49 months; 55 boys, 52 girls).During home visits parents completed questionnaires concerning demographic characteristics, cultural beliefs, parent well-being, and children's socio-emotional adjustment.In addition, mother-child and father-child dyads were videotaped during separate 15-min, semistructured play sessions, from which parent and child expression of emotion was coded for shared positive affect.Results data revealed that parent endorsement of familismo and simpatia cultural beliefs was associated with higher levels of shared positive affect during parent-child interaction.In turn, mother-child shared positive affect was significantly associated with lower maternal self-reported parenting stress.There was no association between father-child shared positive emotion and father reported parenting stress.Nor was there an association between parent-child shared positive affect and parent rated child social competence.However, as predicted high levels of shared positive affect in both mother-child and father-child dyads was associated with lower parent-rated externalizing behavior.

Journal: Infant behavior & development (2022)
Publication types: Journal Article
Construction of competing endogenous RNA interaction network as prognostic markers in metastatic melanoma.

Malignant melanoma (mm) is a malignant tumor originating from melanocytes, with high aggressiveness, high metastasis and extremely poor prognosis.Mm accounts for 4% of skin cancers and 80% of mortality, and the median survival of patients with metastatic melanoma is only about 6 months, with a five-year survival rate of less than 10%.In recent years, the incidence of melanoma has gradually increased and has become one of the serious diseases that endanger human health.Competitive endogenous rna (ce rna) is the main model of the mechanism by which long chain non-coding rnas (lnc rnas) play a regulatory role in the disease.Lnc rnas can act as a "sponge", competitively attracting small rnas (mico rnas; mi rnas), thus interfering with mi rna function, and affect the expression of target gene messenger rnas (m rnas), ultimately promoting tumorigenesis and progression.Bioinformatics analysis can identify potentially prognostic and therapeutically relevant differentially expressed genes in mm, finding lnc rnas, mi rnas and m rnas that are interconnected through the ce rna network, providing further insight into gene regulation and prognosis of metastatic melanoma.Weighted co-expression networks were used to identify lnc rna and m rna modules associated with the metastatic phenotype, as well as the co-expression genes contained in the modules.A total of 17 lnc rnas, six mi rnas, and 11 m rnas were used to construct a ce rna interaction network that plays a regulatory role in metastatic melanoma patients.The prognostic risk model was used as a sorter to classify the survival prognosis of melanoma patients.Four groups of ce rna interaction triplets were finally obtained, which mi r-3662 might has potential implication for the treatment of metaststic melanoma patients, and futher experiments confirmed the regulating relationship and phenotype of this assumption.This study provides new targets to regulate metastatic process, predict metastatic potential and indicates that the mi r-3662 can be used in the treatment of melanoma.

Journal: PeerJ (2021)
Publication types: Journal Article
The Arch Electrode: A Novel Dry Electrode Concept for Improved Wearing Comfort.

Electroencephalography (eeg) is increasingly used for repetitive and prolonged applications like neurofeedback, brain computer interfacing, and long-term intermittent monitoring.Dry-contact electrodes enable rapid self-application.A common drawback of existing dry electrodes is the limited wearing comfort during prolonged application.We propose a novel dry arch electrode.Five semi-circular arches are arranged parallelly on a common baseplate.The electrode substrate material is a flexible thermoplastic polyurethane (tpu) produced by additive manufacturing.A chemical coating of silver/silver-chloride (ag/ag cl) is applied by electroless plating using a novel surface functionalization method.Arch electrodes were manufactured and validated in terms of mechanical durability, electrochemical stability,in vivoapplicability, and signal characteristics.We compare the results of the dry arch electrodes with dry pin-shaped and conventional gel-based electrodes.21-channel eeg recordings were acquired on 10 male and 5 female volunteers.The tests included resting state eeg, alpha activity, and a visual evoked potential.Wearing comfort was rated by the subjects directly after application, as well as at 30 min and 60 min of wearing.Our results show that the novel plating technique provides a well-adhering electrically conductive and electrochemically stable coating, withstanding repetitive strain and bending tests.The signal quality of the arch electrodes is comparable to pin-shaped dry electrodes.The average channel reliability of the arch electrode setup was 91.9 ± 9.5%.No considerable differences in signal characteristics have been observed for the gel-based, dry pin-shaped, and arch-shaped electrodes after the identification and exclusion of bad channels.The comfort was improved in comparison to pin-shaped electrodes and enabled applications of over 60 min duration.Arch electrodes required individual adaptation of the electrodes to the orientation and hairstyle of the volunteers.This initial preparation time of the 21-channel cap increased from an average of 5 min for pin-like electrodes to 15 min for arch electrodes and 22 min for gel-based electrodes.However, when re-applying the arch electrode cap on the same volunteer, preparation times of pin-shaped and arch-shaped electrodes were comparable.In summary, our results indicate the applicability of the novel arch electrode and coating for eeg acquisition.The novel electrode enables increased comfort for prolonged dry-contact measurement.

Journal: Frontiers in neuroscience (2021)
Publication types: Journal Article
Decreasing surface albedo signifies a growing importance of clouds for Greenland Ice Sheet meltwater production.

Clouds regulate the greenland ice sheet's surface energy balance through the competing effects of shortwave radiation shading and longwave radiation trapping.However, the relative importance of these effects within greenland's narrow ablation zone, where nearly all meltwater runoff is produced, remains poorly quantified.Here we use machine learning to merge modis, cloud sat, and calipso satellite observations to produce a high-resolution cloud radiative effect product.For the period 2003-2020, we find that a 1% change in cloudiness has little effect (±0.16 w m-2) on summer net radiative fluxes in the ablation zone because the warming and cooling effects of clouds compensate.However, by 2100 (ssp5-8.5 scenario), radiative fluxes in the ablation zone will become more than twice as sensitive (±0.39 w m-2) to changes in cloudiness due to reduced surface albedo.Accurate representation of clouds will therefore become increasingly important for forecasting the greenland ice sheet's contribution to global sea-level rise.

Journal: Nature communications (2022)
Publication types: Journal Article
Venetoclax ramp-up with concurrent voriconazole in a patient with chronic lymphocytic leukemia.

Introduction chronic lymphocytic leukemia (cll) is commonly treated with the b-cell lymphoma 2 inhibitor (bcl-2) venetoclax.Venetoclax is associated with an increased risk of tumor lysis syndrome in this patient population.Because venetoclax undergoes cyp3a4 metabolism, strong cyp3a4 inhibitors are contraindicated during the ramp-up phase of venetoclax in patients with cll.Case report our case report describes a 58 year old male initially diagnosed with cll in 2013, whose first-line treatment consisted of ibrutinib.The patient developed a central nervous system (cns) aspergillosis infection in 2018, and was initiated on voriconazole.He was subsequently under active surveillance until his disease progressed.The patient was started on venetoclax therapy, while on concomitant voriconazole, for management of his cll.Management and outcome the patient's initial venetoclax dose was 10 mg daily, and he received rasburicase on day 1 of therapy.He tolerated a modified ramp-up phase without complication.After receiving 9 days of inpatient therapy, the patient was discharged on 50 mg of venetoclax to continue outpatient dose escalation.His dose was ultimately escalated to 100 mg daily.Discussion although this report describes the safe administration of venetoclax with voriconazole, extreme caution should be exercised when administering venetoclax with any strong cyp3a4 inhibitor during the ramp-up phase in patients with cll.

Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2022)
Publication types: Case Reports;Journal Article
Sulfur-Induced Growth of Coordination Polymer Derived-Straight Carbon Nanotubes on Carbon Nanofiber Network for Zn-Air Batteries.

Low-cost heteroatom-doped carbon nanomaterials have been widely studied for efficient oxygen reduction reaction and energy storage and conversion in metal-air batteries.A masson pine twigs-like 3-dimensional network construction of carbon nanofibers (cnfs) with abundant straight long co, n, and s-doped carbon nanotubes (cnts) is developed by thermal treatment of co-based polymer coated onto polyacrylonitrile nanofiber network together with thiourea at 900 °c, denoted as cnft-co9s8-900.It is interesting to note that the introduction of a high concentration of sulfur does not lead to the complete toxicity of catalysts, but promotes the axial growth to selectively form straight cnts instead of curly bamboo-like cnts.The highly graphitized in-situ grown co, n, s-doped cnts and the 3-dimensional n-doped cnf network provide both active catalytic sites and highly conductive paths, which are beneficial for oxygen reduction reaction (orr).Thus, the optimal cnft-co9s8-900 performs the excellent orr catalytic activity with a half-wave potential of 0.84 v and a diffusion-limited current density of 5.49 m a cm-2.Furthermore, the cnft-co9s8-900-based zn-air devices also possess a high power density of 136.9 m w cm-2better than commercial pt/c.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (2021)
Publication types: Journal Article
Navigating the Multiverse of Antisense RNAs: The Transcription- and RNA-Dependent Dimension.

Evidence accumulated over the past decades shows that the number of identified antisense transcripts is continuously increasing, promoting them from transcriptional noise to real genes with specific functions.Indeed, recent studies have begun to unravel the complexity of the antisense rna (as rna) world, starting from the multidimensional mechanisms that they can exert in physiological and pathological conditions.In this review, we discuss the multiverse of the molecular functions of as rnas, describing their action through transcription-dependent and rna-dependent mechanisms.Then, we report the workflow and methodologies to study and functionally characterize single as rna candidates.

Journal: Non-coding RNA (2022)
Publication types: Journal Article;Review
Cyanophages as an important factor in the early evolution of oxygenic photosynthesis.

Cyanophages are viruses that infect cyanobacteria.An interesting feature of many of them is the presence of psb a and psb d, genes that encode d1 and d2 proteins, respectively.The d1 and d2 are core proteins of the photosystem ii (psii) in cyanobacteria, algae and plants and influence the proper function of oxygenic photosynthesis (op) in all oxyphototrophs on earth.The frequent occurrence of psb a and psb d in cyanophages raises the question whether these genes coevolved with hosts during the early stages of cyanophage and cyanobacterial evolution, or whether they are direct descendants of genes adopted from the genomes of cyanobacterial hosts.The phylogeny of d1/d2 proteins encoded in the genomes of selected cyanophages and oxyphototrophs was reconstructed.In addition, common ancestral sequences of d1 and d2 proteins were predicted for cyanophages and oxyphototrophs.Based on this, the reconstruction of the 3d structures of d1 and d2 proteins was performed.In addition, the ratio of non-synonymous to synonymous (d n/d s) nucleotide substitutions in the coding sequences (cdss) of psb a and psb d was determined.The results of the predicted spatial structures of the d1 and d2 proteins and purifying selection for the cdss of psb a and psb d suggest that they belong to the ancient proteins, which may have formed the primordial psii.It cannot be ruled out that they involved in water oxidation in cyanobacteria-like organisms at early stages of the evolution of life on earth and coevolved with ancient cyanophages.The data are also discussed in the context of the origin of viruses.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Metabolic Engineering ofSaccharomyces cerevisiaefor Heterologous Carnosic Acid Production.

Carnosic acid (ca), a phenolic tricyclic diterpene, has many biological effects, including anti-inflammatory, anticancer, antiobesity, and antidiabetic activities.In this study, an efficient biosynthetic pathway was constructed to produce ca in saccharomyces cerevisiae.First, the ca precursor miltiradiene was synthesized, after which the ca production strain was constructed by integrating the genes encoding cytochrome p450 enzymes (p450s) and cytochrome p450 reductase (cpr) sm cpr.The ca titer was further increased by the coexpression of cyp76ah1 and sm cpr ∼t28sp cytb5 fusion proteins and the overexpression of different catalases to detoxify the hydrogen peroxide (h2o2).Finally, engineering of the endoplasmic reticulum and cofactor supply increased the ca titer to 24.65 mg/l in shake flasks and 75.18 mg/l in 5 l fed-batch fermentation.This study demonstrates that the ability of engineered yeast cells to synthesize ca can be improved through metabolic engineering and synthetic biology strategies, providing a theoretical basis for microbial synthesis of other diterpenoids.

Journal: Frontiers in bioengineering and biotechnology (2022)
Publication types: Journal Article
Evaluation of the Optimal Uses of Five Genotypes ofMusa textilisFiber Grown in the Tropical Region.

Knowing the genotypes of musa textilisand its fiber production properties is key for developing cultivars with homogeneous properties and focusing on specific products or market segments that generate added value to the fiber.For this reason, the objective was to determine the optimal use of five genotypes of m.Textilis(mt01, mt03, mt07, mt11, and cf01) with high productivity grown in the tropical region of costa rica.Therefore, anatomical, physical-mechanical, chemical, and energetic analyses were carried out on these fibers to define whether any genotype has the ideal conditions for a specific use.The results showed differences between the genotypes, obtaining significant differences in physical-mechanical properties (tension, water retention, and color), chemical properties (holocellulose, lignin, extractives, and elemental values of nitrogen, carbon, and sulfur), and energetic properties (volatiles, ash, and caloric value thermogravimetric analyses), which resulted in the establishment of two groups of genotypes with a dissimilarity degree of 35%.The first group, composed of mt03 and mt01, presented characteristics suitable for paper production, biodegradable materials, and composite materials.On the other hand, the second group, made up of mt07, mt11, and cf01, showed properties suitable for textiles, heavy-duty fibers, and bioenergy.

Journal: Polymers (2022)
Publication types: Journal Article
Development of a machine learning algorithm for predicting in-hospital and 1-year mortality after traumatic spinal cord injury.

Context current prognostic tools such as the injury severity score (iss) that predict mortality following trauma do not adequately consider the unique characteristics of traumatic spinal cord injury (t sci).Purpose our aim was to develop and validate a prognostic tool that can predict mortality following t sci.Study design retrospective review of a prospective cohort study.Patient sample data was collected from 1245 persons with acute t sci who were enrolled in the rick hansen spinal cord injury registry between 2004 and 2016.Outcome measures in-hospital and 1-year mortality following t sci.Methods machine learning techniques were used on patient-level data (n=849) to develop the spinal cord injury risk score (scirs) that can predict mortality based on age, neurological level and completeness of injury, aospine classification of spinal column injury morphology, and abbreviated injury scale scores.Validation of the scirs was performed by testing its accuracy in an independent validation cohort (n=396) and comparing its performance to the iss, a measure which is used to predict mortality following general trauma.Results for 1-year mortality prediction, the values for the area under the receiver operating characteristic curve (auc) for the development cohort were 0.84 (standard deviation=0.029) for the scirs and 0.55 (0.041) for the iss.For the validation cohort, auc values were 0.86 (0.051) for the scirs and 0.71 (0.074) for the iss.For in-hospital mortality, auc values for the development cohort were 0.87 (0.028) and 0.60 (0.050) for the scirs and iss, respectively.For the validation cohort, auc values were 0.85 (0.054) for the scirs and 0.70 (0.079) for the iss.Conclusions the scirs can predict in-hospital and 1-year mortality following t sci more accurately than the iss.The scirs can be used in research to reduce bias in estimating parameters and can help adjust for coefficients during model development.Further validation using larger sample sizes and independent datasets is needed to assess its reliability and to evaluate using it as an assessment tool to guide clinical decision-making and discussions with patients and families.

Journal: The spine journal : official journal of the North American Spine Society (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't