syedzayyan/paper_mill_benchmark huggingface dataset:
Leptin receptor and prolactin in pubertal disorders and chronic kidney disease.

Knowledge of chronic kidney disease (ckd) with pubertal disorders (pd) in adolescent boys is limited as few studies have explored this disorder.This study aimed to identify the usefulness of assessing hormonal parameters in male adolescents with ckd and their correlation with pd in a 12-month follow-up period.Methods a prospective cohort study was conducted among male adolescents with ckd (stages iv and v).Data regarding the age at puberty onset were collected from the patients' clinical records and through interview.The patients were followed up for 12 months during their pubertal development.At the beginning, routine hormonal profile tests were performed to examine the patients' thyroid profile, prolactin levels, luteinizing hormone, follicle-stimulating hormone, testosterone, leptin, and receptor leptin.The hormonal profiles of patients with and without pd were compared.Comparisons between the groups were performed using the student t-test and fisher's exact tests.Logistic regression analysis was also performed.Results data of 64 patients (26/64 with pd) were analyzed.The median age was 15 years and the median time for ckd evolution was 11 months.No differences between groups were noted in the general or biochemical characteristics of the patients.The hormonal parameters, prolactin levels were higher and the free leptin and free thyroxine levels were lower in patients with pd.Leptin receptor levels of >0.90 ng/m l (risk ratio [rr], 8.6; p = 0.004) and hyperprolactinemia (rr, 21.3; p = 0.049) were the risk factors for pd.Conclusions leptin receptor levels of >0.90 ng/m l and hyperprolactinemia are associated with the development of pd in male adolescents with ckd.

Journal: Pediatrics international : official journal of the Japan Pediatric Society (2022)
Publication types: Journal Article
Biosynthesis of the catalytic H-cluster of [FeFe] hydrogenase: the roles of the Fe-S maturase proteins HydE, HydF, and HydG.

[fe fe] hydrogenases carry out the redox interconversion of protons and molecular hydrogen (2h++ 2e-⇌ h2) at a complex fe-s active site known as the h-cluster.The h-cluster consists of a [4fe-4s] subcluster, denoted here as [4fe]h, linkedviaa cysteine sulfur to an interesting organometallic [2fe]hsubcluster thought to be the subsite where the catalysis occurs.This [2fe]hsubcluster consists of two fe atoms, linked with a bridging co and a bridging sch2nhch2s azadithiolate (adt), with additional terminal co and cn ligands bound to each fe.Synthesizing such a complex organometallic unit is a fascinating problem in biochemistry, complicated by the toxic nature of both the co and cn-species and the relative fragility of the azadithiolate bridge.It has been known for a number of years that this complex biosynthesis is carried out by a set of three essential fe-s proteins, hyd e, hyd f, and hyd g.Hyd f is a gtpase, while hyd e and hyd g are both members of the large family of radical s-adenosylmethionine (r sam) enzymes.In this perspective we describe the history of research and discovery concerning these three fe-s "maturase" proteins and describe recent evidence for a sequential biosynthetic pathway beginning with the synthesis of a mononuclear organometallic [fe(ii)(co)2cn(cysteine)] complex by the r sam enzyme hyd g and its subsequent activation by the second r sam enzyme hyd e to form a highly reactive fe(i)(co)2(cn)s species.In our model a pair of these fe(i)(co)2(cn)s units condense to form the [fe(co)2(cn)s]2diamond core of the [2fe]hcluster, requiring only the installation of the central ch2nhch2portion of the azadithiolate bridge, whose atoms are all sourced from the amino acid serine.This final step likely occurs with an interplay of hyd e and hyd f, the details of which yet remain to be elucidated.

Journal: Chemical science (2020)
Publication types: Journal Article;Review
Does Public Housing Increase the Risk of Child Health Problems? Evidence from Linked Survey-Administrative Data.

Research on the effects of major federal housing assistance programs on children's outcomes has produced mixed results.Although housing assistance programs provide one of the few sources of affordable and stable housing for low-income families, there remains concern that living in public housing developments increases the risk of poor health for children.This paper uses a unique survey-administrative linked dataset to examine the effect of living in public housing on children's risk of health problems, including frequent diarrhea, frequent headaches, skin allergies, asthma, and fair/poor health status.Children living in public housing have substantially more health problems than children who do not live in public housing.However, the analysis develops several additional comparison groups to demonstrate that the excess health problems reflect unobserved selection into public housing.The main selection adjustment compares children living in public housing to children who enter public housing in the near future.Results indicate that public housing does not increase the risk of child health problems, and it is important to consider the substantial selection into public housing on factors that are likely to be correlated with children's outcomes.The broad effects of public housing may be mixed, but policymakers should not confuse the economic and health challenges of public housing residents for the effects of the program itself.

Journal: Housing policy debate (2022)
Publication types: Journal Article
Linagliptin-associated bullous pemphigoid treated with rituximab.

Dipeptidyl peptidase 4 (dpp-4) inhibitors are increasingly used these days in management of diabetes.There has been reported in a few case reports of increasing association between dpp-4 inhibitor use and bullous pemphigoid (bp).We report a case of association between linagliptin use and bp and subsequent treatment with rituximab.

Journal: BMJ case reports (2019)
Publication types: Case Reports;Journal Article
Study of sleep disorders in the elderly visiting geriatrics department.

Context sparse published data are available from india regarding sleep disorders in elderly, sleep quality, and daytime sleepiness.Aims to study sleep disturbances in the elderly (>60 years) subjects.Settings and design hospital-based cross-sectional study.Methods and material all the subjects underwent a thorough clinical evaluation which included detailed history and a thorough physical examination.The daytime sleepiness was assessed using the epworth sleepiness scale (ess).The sleep quality (sq) was evaluated with the pittsburgh sleep quality index (psqi).Statistical analysis used association between categorical variables was studied by chi-square (χ2) test with continuity correction.All tests were two-tailed; a pvalue 10 suggestive of increased day time sleepiness.Sixty-four (52.5%) were labelled "bad sleepers" (psqi >5).Compared with those with ≤3 comorbid conditions, a higher proportion of elderly with >3 comorbid conditions had significantly higher occurrence of poor sleep quality (psqi >5) and daytime sleepiness (ess >10).Increased daytime sleepiness (ess >10) was significantly high in patients with osteoarthritis and cerebrovascular disease.Conclusions our observations suggest that a high proportion of elderly subjects who did not complain of sleep-related symptoms were found to have poor sleep quality.Therefore, incorporating sq assessment as a part of routine geriatric assessment screening would be beneficial in early detection of this condition.

Journal: Journal of family medicine and primary care (2022)
Publication types: Journal Article
High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis.

Maternal obesity has been reported to be related to neurodevelopmental disorders in the offspring.However, the underlying mechanisms and effective interventions remain unclear.This cross-sectional study with 778 children aged 7-14 years in china indicated that maternal obesity is strongly associated with children's lower cognition and sociality.Moreover, it has been demonstrated that maternal obesity in mice disrupted the behavior and gut microbiome in offspring, both of which were restored by a high-fiber diet in either dams or offspring via alleviating synaptic impairments and microglial maturation defects.Co-housing and feces microbiota transplantation experiments revealed a causal relationship between microbiota and behavioral changes.Moreover, treatment with the microbiota-derived short-chain fatty acids also alleviated the behavioral deficits in the offspring of obese dams.Together, our study indicated that the microbiota-metabolites-brain axis may underlie maternal obesity-induced cognitive and social dysfunctions and that high dietary fiber intake could be a promising intervention.

Journal: Cell metabolism (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The kinesin Eg5 inhibitor K858 induces apoptosis and reverses the malignant invasive phenotype in human glioblastoma cells.

Glioblastoma multiforme is the most common primary malignant brain tumor and its current chemotherapeutic options are limited to temozolomide.Recently, some synthetic compounds acting as inhibitors of kinesin spindle protein eg5 have shown pronounced antitumor activity.Our group has recently demonstrated that one of these kinesin eg5 inhibitors, named k858, exerted important antiproliferative and apoptotic effects on breast cancer cells.Since glioblastoma cells usually express high levels of kinesin eg5, we tested the effect of k858 on two human glioblastoma cell lines (u-251 and u-87) and found that k858 inhibited cell growth, induced apoptosis, reversed epithelial-mesenchymal transition and inhibited migration in both cell lines.We also detected that, at the same time, k858 increased the expression of survivin, an anti-apoptotic molecule, and that the forced down-regulation of survivin, obtained with the specific inhibitor ym155, boosted k858-dependent apoptosis.This indicated that the anti-tumor activity of k858 on glioblastoma cells is limited by the over-expression of survivin and that the negative regulation of this protein sensitizes tumor cells to k858.These data confirmed that kinesin eg5 is an interesting target for new therapeutic approaches for glioblastoma.We showed that k858, specifically, was a potent inhibitor of replication, an inducer of apoptosis and a negative regulator of the invasive phenotype for glioblastoma cells.

Journal: Investigational new drugs (2018)
Publication types: Journal Article
Experimental Study on the Quenching Behavior of a Copper Cube in the Cellulose Nanofiber Solution.

This study investigates the quenching behavior and heat transfer characteristics of a copper cube immersed in cellulose nanofiber (cnf) solutions.The heat transfer performance of cnf solutions during boiling has been examined in several studies, but the quenching behavior of cnf solutions, which is an important heat transfer method, has not been evaluated.In this study, four copper cubes with the same dimensions and four different quenchants (deionized water and 0.01%, 0.1% and 0.5% cnf solutions) were prepared.A copper cube heated to greater than 600 °c was submerged three times in the quenchant.This was repeated with different copper cubes in each of the quenchants.The time at which the heated copper cube convectively transferred heat to the surroundings was recorded.The cooling time was shortest when the cube was immersed in a 0.5% cnf solution for the first time.The average cooling time for quenching in the 0.5% cnf solution was 30.3% shorter than that in di water.In this study, film boiling during quenching was thoroughly observed and analyzed to explain the cause of enhancement in heat transfer efficiency.

Journal: Nanomaterials (Basel, Switzerland) (2022)
Publication types: Journal Article
Twenty-four-hour Urine Testing and Urinary Stone Disease Recurrence in Veterans.

To determine whether 24-hour urine testing in veterans with usd (urinary stone disease) reduces or delays urinary stone recurrence.Methods cohort study of national health record data from veterans health administration from 2007 through 2013.We utilized a study population of 130,129 veterans with usd based on diagnostic or procedural codes and excluded those with usd claims in the 2 years before cohort entry.We then created a propensity-score matched cohort of 14,854 veterans based on completion of 24-hour urine testing within 6 months of stone diagnosis.Primary outcome was time-to-next clinically significant stone event, defined as an emergency department visit, inpatient admission related to a urinary stone, or urologic stone procedure with 5-year follow up.Results of 14,854 veterans in the propensity-score matched cohort, 8560 (57.6%) experienced a recurrent usd event.Completion of 24-hour urine testing was associated with a higher risk of developing a second stone event (hazard ratio [hr] 1.17, 95% confidence interval [95% ci] 1.12-1.22).Among veterans with known recurrent disease, we examined time to a third stone event.In this cohort of 4736 patients, completion of 24-hour urine testing was not associated with a higher risk of developing a third stone event (hr 1.06, 95% ci 0.99-1.12).Conclusion completion of 24-hour urine testing was not associated with a reduction in urinary stone recurrence.These findings challenge the validity of a longstanding recommendation in general medicine, nephrology, and urology practice.

Journal: Urology (2022)
Publication types: Journal Article
Closely-related Borrelia burgdorferi (sensu stricto) strains exhibit similar fitness in single infections and asymmetric competition in multiple infections.

Wild hosts are commonly co-infected with complex, genetically diverse, pathogen communities.Competition is expected between genetically or ecologically similar pathogen strains which may influence patterns of coexistence.However, there is little data on how specific strains of these diverse pathogen species interact within the host and how this impacts pathogen persistence in nature.Ticks are the most common disease vector in temperate regions with borrelia burgdorferi, the causative agent of lyme disease, being the most common vector-borne pathogen in north america.Borrelia burgdorferi is a pathogen of high public health concern and there is significant variation in infection phenotype between strains, which influences predictions of pathogen dynamics and spread.Methods in a laboratory experiment, we investigated whether two closely-related strains of b.Burgdorferi (sensu stricto) showed similar transmission phenotypes, how the transmission of these strains changed when a host was infected with one strain, re-infected with the same strain, or co-infected with two strains.Ixodes scapularis, the black-legged tick, nymphs were used to sequentially infect laboratory-bred peromyscus leucopus, white-footed mice, with one strain only, homologous infection with the same stain, or heterologous infection with both strains.We used the results of this laboratory experiment to simulate long-term persistence and maintenance of each strain in a simple simulation model.Results strain lg734 was more competitive than bl206, showing no difference in transmission between the heterologous infection groups and single-infection controls, while strain bl206 transmission was significantly reduced when strain lg734 infected first.The results of the model show that this asymmetry in competition could lead to extinction of strain bl206 unless there was a tick-to-host transmission advantage to this less competitive strain.Conclusions this asymmetric competitive interaction suggests that strain identity and the biotic context of co-infection is important to predict strain dynamics and persistence.

Journal: Parasites & vectors (2017)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, U.S. Gov't, Non-P.H.S.;Research Support, Non-U.S. Gov't
Application ofAspergillus nigerFumonisin Amine Oxidase (AnFAO) to Detoxify Fumonisin-Contaminated Maize.

Fumonisin mycotoxins are a family of secondary metabolites produced by fusarium verticillioidesand related species, as well as some strains of aspergillus niger.Fumonisin contamination of maize is a concern when grown under hot, dry conditions.When present above regulatory levels, there can be effects on animal health.New tools to reduce the toxicity of maize and maize products with high concentrations of fumonisin are needed.Recently, we reported an amine oxidase (an fao) from a fumonisin-producing aspergillus nigerstrain capable of oxidatively deaminating intact fumonisins.In this study, an fao was used to reduce intact fumonisin concentrations in milled maize flour, whole kernel maize inoculated with fumonisin-producing fusarium verticillioides, and dried distillers' grains with solubles (ddgs).The data showed that milled maize flour incubated with 1 μm an fao for 1 h resulted in complete deamination of fb1and fb2.A greater than 90% reduction in fb1-3concentrations was observed following a simple washing procedure of whole kernel maize in the presence of 1 μm an fao for 1 h.Similarly, a ≥86% reduction in fb1-3concentrations was observed in ddgs after 4 h incubation with 1 μm an fao.Finally, we engineered the methylotrophic yeast pichia pastoristo produce functional an fao in both a secreted and intracellular form.These results support the further development and application of an fao as a promising tool to remediate fumonisin-contaminated maize and maize products.

Journal: Toxins (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Task demands modulate the effects of speech on text processing.

Task-irrelevant background sound can disrupt performance of visually based cognitive tasks.The cross-modal breakdown of attentional selectivity in the context of reading was addressed using analyses of eye movements.Moreover, the study addressed whether task-sensitivity to distraction via background speech on reading was modulated by the cognitive demands of the focal task.Two randomly-assigned groups of native chinese participants read the same set of chinese experimental sentences while being exposed to meaningful speech, meaningless (foreign) speech, or silence.For one group, participants were instructed to judge whether the sentences made sense (i.e., semantic acceptability task); for another, participants were instructed to detect whether the sentences contained a noncharacter (i.e., noncharacter detection task).Results showed no significant effect across sound conditions for the noncharacter detection task.For the semantic acceptability task, however, there was a substantial disruptive effect of the meaningfulness of the speech.Compared with reading with meaningless speech or reading in silence, the meaningful speech increased numbers of fixations, regressions, regression path, and total reading times.These results suggest that the disruption of reading by background speech is jointly dependent on the nature of the speech and the task process deployed, thereby favoring an interference-by-process account over interference-by-content and attentional diversion accounts of distraction to reading by background sound.(psyc info database record (c) 2020 apa, all rights reserved).

Journal: Journal of experimental psychology. Learning, memory, and cognition (2020)
Publication types: Journal Article
Autophagic Survival Precedes Programmed Cell Death in Wheat Seedlings Exposed to Drought Stress.

Although studies have shown the concomitant occurrence of autophagic and programmed cell death (pcd) in plants, the relationship between autophagy and pcd and the factors determining this relationship remain unclear.In this study, seedlings of the wheat cultivar jimai 22 were used to examine the occurrence of autophagy and pcd during polyethylene glycol (peg)-8000-induced drought stress.Autophagy and pcd occurred sequentially, with autophagy at a relatively early stage and pcd at a much later stage.These findings suggest that the duration of drought stress determines the occurrence of pcd following autophagy.Furthermore, the addition of 3-methyladenine (3-ma, an autophagy inhibitor) and the knockdown of autophagy-related gene 6 (atg6) accelerated peg-8000-induced pcd, respectively, suggesting that inhibition of autophagy also results in pcd under drought stress.Overall, these findings confirm that wheat seedlings undergo autophagic survival under mild drought stress, with subsequent pcd only under severe drought.

Journal: International journal of molecular sciences (2019)
Publication types: Journal Article
Adhaeribacter soli sp. nov., a bacterium isolated from soil in Korea.

Strain ma2twas isolated from a soil sample from gijang-gun, busan in korea.The strain, a gram-stain-negative aerobic bacterium, is non-motile, ovoid- or rod-shaped, catalase- and oxidase-positive, and grows at na cl concentrations 1% (w/v), at 15-30 °c (optimum 25 °c) and at p h 6-8.5 (optimum p h 7.5).The 16s r rna gene sequence indicates that it belongs to the genus adhaeribacter in the family hymenobacteraceae.Phylogenetically, its closest relatives are adhaeribacter terrae hy02tand adhaeribacter terreus dng6t, to which the strain shows 16s r rna gene sequence similarity values of 96.6 and 96.0%, respectively.The major fatty acids (> 5% of the total fatty acids) of strain ma2tare c15:0iso, c15:0iso-g and summed feature 4 (anteiso-c17:1b and/or iso-c17:1i).The only detected isoprenoid quinone of strain ma2tis mk-7.The major polar lipid was phosphatidylethanolamine.The draft genome sequence of strain ma2thas a size of 4.9 mkb.The genomic dna g + c content was 46.9 mol%.Based on the phylogenetic, genotypic, phenotypic and chemotaxonomic data, the strain represents a novel species of the genus adhaeribacter, for which the name adhaeribacter soli sp.Nov.Is proposed.Strain ma2t(= kctc 72630t= nbrc 114192t) is the type strain.

Journal: Archives of microbiology (2021)
Publication types: Journal Article
Qualitative analysis of sinus surgery posts on popular social media platforms.

Introduction social media platforms are constantly evolving and expanding to new populations, exposing their users to various topics and serving as an informal educational resource.Medical ideas and topics are freely discussed online, making understanding of what is present on these platforms of particular importance to the practicing medical professional.In the field of otolaryngology, the public social media portrayal of sinus surgery has not been previously reported.Methods social media posts using keywords related to sinus surgery on facebook, instagram, and tik tok were qualitatively analyzed and categorized based on media type, author, subject, timing, depiction, and popularity.Results the total number of posts included in final analysis was 1798, with a majority stemming from instagram (68.5%), then facebook (20.2%) and finally tik tok (11.3%).The most common type of media analyzed was images (69.0%) and patients were more often authors of posts (45.1%) as compared to physicians (34.8%).The subjects of the posts were nearly equally reassurance regarding surgery (41.3%) and educational or informational posts (38.8%) and were most commonly timed in the postoperative period (41.3%).Sinus surgery was depicted in a positive fashion most frequently (56.6%), notably compared against the negative portrayal at 3.2%.Negative posts most commonly cited postoperative pain or bleeding.Conclusions most social media posts analyzed in this multi-platform study depicted sinus surgery in a positive fashion.Patients tended to post in the postoperative or perioperative period, whereas physicians tender to post intraoperative educational posts.Negative posts were most commonly centered around postoperative pain.Cautious interpretation of these results could be used for improving patient care and outreach in the digital age.

Journal: American journal of otolaryngology (2022)
Publication types: Journal Article