syedzayyan/paper_mill_benchmark huggingface dataset:
A Heart Healthy Intervention Improved Tobacco Screening Rates and Cessation Support in Primary Care Practices.

We examined whether an evidence-based cardiovascular disease risk reduction intervention (heart health now) would improve rates for tobacco cessation screening and counseling in small primary care practices in north carolina.Heart health now was a stepped wedge, stratified, cluster randomized trial for primary care practices that were staffed by 10 or fewer clinicians and had an electronic health record.The heart health now intervention consisted of education tools, onsite practice facilitation for one year, and a practice-specific cardiovascular population management dashboard that included monthly, measure-specific run charts to help guide quality improvement.Our primary outcomes were practice-level rates of tobacco screening and tobacco cessation support-extracted from practices' electronic health records-and measured at pre-intervention and 6 months post-intervention.The 28 practices included in our analyses represented 78,120 patients and 17,687 smokers.Significant change occurred in practices' tobacco screening rates and cessation support rates over time.From pre- to post-intervention, screening rates significantly increased from 82.7 to 96.2% (p < 0.001).Similarly, cessation support rates significantly increased from 44.3 to 50.1% (p = 0.03).Several practice-level factors were associated with improvement including being in an academic health center or faculty practice, having more clinicians, and having a lower percentage of white patients.In conclusion, a multi-component intervention focused on multiple cardiovascular disease risk reduction in multiple small primary care practices successfully improved rates of tobacco screening and cessation support.

Journal: Journal of prevention (2022) (2022)
Publication types: Journal Article;Randomized Controlled Trial;Research Support, U.S. Gov't, P.H.S.
Designing a Mixed Multilayer Wavelet Neural Network for Solving ERI Inversion Problem With Massive Amounts of Data: A Hybrid STGWO-GD Learning Approach.

This study aims to develop a novel wavelet neural-network (wnn) model for solving electrical resistivity imaging (eri) inversion with massive amounts of measured data in control and measurement fields.In the proposed method, we design a mixed multilayer wnn (mmwnn) which uses morlet and mexican wavelons as different activation functions in a cascaded hidden layer structure.Meanwhile, a hybrid stgwo-gd learning approach is used to improve the learning ability of the mmwnn, which is a combination of the self-tuning grey wolf optimizer (stgwo) and the gradient descent (gd) algorithm adopting the advantages of each other.Moreover, updating formulas of the gd algorithm are derived, and a gaussian updating operator with weighted hierarchical hunting, a chaotic oscillation equation, and a nonlinear modulation coefficient are introduced to improve the hierarchical hunting and the control parameter adjustment of the modified stgwo.Five examples are used with the aim of assessing the availability and feasibility of the proposed inversion method.The inversion results are promising and show that the introduced method is superior to other competitors in terms of inversion accuracy and computational efficiency.Furthermore, the effectiveness of the proposed method is demonstrated over a classical benchmark successfully.

Journal: IEEE transactions on cybernetics (2022)
Publication types: Journal Article
Lipidomics Profiling of HepG2 Cells and Interference by Mycotoxins Based on UPLC-TOF-IMS.

Discovering the fungus-infected or mycotoxin-contaminated biomarkers is significant for systems biology since the metabolites in biological samples have significant polarity differences in both stochastic gene expression and microenvironmental change.Here, we aim to establish a comprehensive method for a lipidome by ion mobility mass spectrometry (ims) merged with chemometrics to accurately find out the more scientific markers of cell interference by mycotoxins and for pathogenesis exploration and drug development.The differences in the abundances of several small molecules found in these metabolites were explored through multivariate statistical analysis, including principal component analysis (pca) and orthogonal partial least-squares discriminant analysis (opls-da), to further screen biomarkers.Good applicability and predictability were demonstrated by r2(x) and q2(r2= 0.959,q2= 0.999).Five compounds withm/zvalues of 512.502 8, 540.5343, 722.525 8, 787.667 5, and 813.683 0 were selected as markers, and four of them were further confirmed by chemical standards (i.e., msms ofm/z813.683 0 coveringm/z86.0978, 125.0008, 184.0745, and 185.0781).In summary, we demonstrated the integration of uplc-tof-ims and the chemometrics approach to elucidate identified biomarkers, which also provides a new way of thinking for covering lipid biomarkers or prognostic indicators for mycotoxins.

Journal: Analytical chemistry (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
High-Frequency Intraoral Ultrasound for Preoperative Assessment of Depth of Invasion for Early Tongue Squamous Cell Carcinoma: Radiological-Pathological Correlations.

The eighth edition of the tnm classification officially introduced "depth of invasion" (doi) as a criterion for determining the t stage in tongue squamous cell carcinoma.The doi is a well-known independent risk factor for nodal metastases.In fact, several experts strongly suggest elective neck dissection for tongue cancer with a doi > 4 mm due to the high risk of early and occult nodal metastases.Imaging plays a pivotal role in preoperative assessments of the doi and, hence, in planning the surgical approach.Intraoral ultrasound (ious) has been proposed for early-stage scc of the oral tongue as an alternative to magnetic resonance imaging (mri) for local staging.The aim of this work is to investigate the accuracy of ious in the assessment of the doi in early oral scc (cis, p t1, and p t2).A total of 41 patients with tongue sccs (cis-t2) underwent a preoperative high-frequency ious.An ious was performed using a small-size, high-frequency hockey-stick linear probe.The ultrasonographic doi (us doi) was retrospectively compared to the pathological doi (p doi) as the standard reference.In patients who underwent a preoperative mri, their us doi, magnetic resonance doi (mri doi), and p doi were compared.Specificity and sensitivity for the ious to predict a p doi > 4 mm and to differentiate invasive and noninvasive tumors were also evaluated.A high correlation was found between the p doi and us doi, p doi and mri doi, and us doi and mri doi (spearman's ρ = 0.84,p< 0.0001, spearman's ρ = 0.79,p< 0.0001, and spearman's ρ = 0.91,p< 0.0001, respectively).A bland-altman plot showed a high agreement between the us doi and p doi, even though a mean systematic error was found between the us doi and p doi (0.7 mm), mri doi and p doi (1.6 mm), and us doi and mri doi (-0.7 mm).The ious was accurate at determining the t stage (p< 0.0001).The sensitivity and specificity for the ious to predict a p doi ≥4 mm were 92.31% and 82.14%, respectively, with an auc of 0.87 (p< 0.0001).The specificity, sensitivity, negative predictive value (npv), and positive predictive value (ppv) for the ious to predict an invasive cancer were 100%, 94.7%, 60%, and 100%, respectively.The auc was 0.8 (95% ci 0.646-0.908,p< 0.0001).The ious was accurate in a preoperative assessment of a p doi and t stage, and can be proposed as an alternative to mri in the preoperative staging of tongue scc.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article
Selected matrix metalloproteinases activity and hypertension-mediated organ damage in relation to uric acid serum level.

Atherosclerosis is as a systemic inflammatory disease associated with the activationof many mediators, including matrix metalloproteinases (mmps), and may be amplified by abnormal high serum uric acid (ua) concentration (hyperuricemia, hu).The aim of the study was to determine the relationship between serum ua concentration and activity of mmps and their correlation with the hypertension-mediated organ damage (hmod) intensity.Methods one hundred and nine patients untreated with antihypertensive, hypolipemic or uratelowering drugs with diagnosed stage 1-2 essential hypertension were included in this study.In all participants blood pressure (bp) was measured, carotid-femoral pulse wave velocity (pwv), intima-media thickness (imt), echocardiography and blood tests including ua, lipids and serum concentrations of mmps (1, 2, 3, 9) were observed.The participants were divided into hyper- and normuricemic groups.Results uric acid concentration in the whole study group positively correlated with some hmod parameters (imt, pwv, left ventricular mass index, left atrial dimension).Among the studied metalloproteinases only mmp-3 activity positively correlated with serum ua concentration independently of age, body mass index and serum lipids (r2 = 0.11, p = 0.048).Multivariate regression analysis showed positive association between imt and bp, ua concentration and mmp-3 activity, independently of waist circumference and serum lipids (r2 = 0.328, p < 0.002).Patients with hu were characterized by higher activity of mmp-3 than those without (19.41 [14.45; 21.74] vs.13.98 [9.52; 18.97] ng/m l, p = 0.016).Conclusions the present results may support the thesis that ua and the increased by ua activity of mmps may take part in the development of hmod, especially imt.

Journal: Cardiology journal (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Surgical treatment of esotropia and unilateral ptosis in a patient with Cornelia de Lange syndrome.

Cornelia de lange syndrome (cd ls) is a rare multisystemic disorder that is characterized by mental retardation, prenatal and postnatal growth retardation, limb anomalies, and distinctive facial features, which include arched eyebrows that often meet in the middle (synophrys), long eyelashes, low-set ears, small and widely spaced teeth, and a small and upturned nose.Ophthalmic manifestations include long eyelashes, nasolacrimal duct obstruction, myopia, ptosis, and strabismus.There has been no report of surgical treatment for esotropia and unilateral ptosis in patients with cd ls in korea.I report a patient with cd ls who underwent surgical treatment for esotropia and unilateral ptosis with a good surgical outcome.

Journal: Yeungnam University journal of medicine (2019)
Publication types: Case Reports;Journal Article
Capturing Mobile Lithium Ions in a Molecular Hole Transporter Enhances the Thermal Stability of Perovskite Solar Cells.

A thermally stable perovskite solar cell (psc) based on a new molecular hole transporter (mht) of 1,3-bis(5-(4-(bis(4-methoxyphenyl) amino)phenyl)thieno[3,2-b]thiophen-2-yl)-5-octyl-4h-thieno[3,4-c]pyrrole-4,6(5h)-dione (coded hl38) is reported.Hole mobility of 1.36 × 10-3cm2v-1s-1and glass transition temperature of 92.2 °c are determined for the hl38 doped with lithium bis(trifluoromethanesulfonyl)imide and 4-tert-butylpyridine as additives.Interface engineering with 2-(2-aminoethyl)thiophene hydroiodide (2-teai) between the perovskite and the hl38 improves the power conversion efficiency (pce) from 19.60% (untreated) to 21.98%, and this champion pce is even higher than that of the additive-containing 2,2',7,7'-tetrakis(n,n-di-p-methoxyphenylamine)-9,9'-spirobifluorene (spiro-me otad)-based device (21.15%).Thermal stability testing at 85 °c for over 1000 h shows that the hl38-based psc retains 85.9% of the initial pce, while the spiro-me otad-based psc degrades unrecoverably from 21.1% to 5.8%.Time-of-flight secondary-ion mass spectrometry studies combined with fourier transform infrared spectroscopy reveal that hl38 shows lower lithium ion diffusivity than spiro-me otad due to a strong complexation of the li+with hl38, which is responsible for the higher degree of thermal stability.This work delivers an important message that capturing mobile li+in a hole-transporting layer is critical in designing novel mhts for improving the thermal stability of pscs.In addition, it also highlights the impact of interface design on non-conventional mhts.

Journal: Advanced materials (Deerfield Beach, Fla.) (2021)
Publication types: Journal Article
Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations.

To elucidate the pathogenesis of vein of galen malformations (vogms), the most common and most severe of congenital brain arteriovenous malformations, we performed an integrated analysis of 310 vogm proband-family exomes and 336,326 human cerebrovasculature single-cell transcriptomes.We found the ras suppressor p120 ras gap (rasa1) harbored a genome-wide significant burden of loss-of-function de novo variants (2042.5-fold, p = 4.79 x 10-7).Rare, damaging transmitted variants were enriched in ephrin receptor-b4 (ephb4) (17.5-fold, p = 1.22 x 10-5), which cooperates with p120 ras gap to regulate vascular development.Additional probands had damaging variants in acvrl1, notch1, itgb1, and ptpn11.Acvrl1 variants were also identified in a multi-generational vogm pedigree.Integrative genomic analysis defined developing endothelial cells as a likely spatio-temporal locus of vogm pathophysiology.Mice expressing a vogm-specific ephb4 kinase-domain missense variant (phe867leu) exhibited disrupted developmental angiogenesis and impaired hierarchical development of arterial-capillary-venous networks, but only in the presence of a "second-hit" allele.These results illuminate human arterio-venous development and vogm pathobiology and have implications for patients and their families.

Journal: Nature communications (2023)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Effects of electromagnetic waves on pathogenic viruses and relevant mechanisms: a review.

Pathogenic viral infections have become a serious public health issue worldwide.Viruses can infect all cell-based organisms and cause varying injuries and damage, resulting in diseases or even death.With the prevalence of highly pathogenic viruses, such as severe acute respiratory syndrome coronavirus 2 (sars-co v-2), it is urgent to develop efficient and safe approaches to inactivate pathogenic viruses.Traditional methods of inactivating pathogenic viruses are practical but have several limitations.Electromagnetic waves, with high penetration capacity, physical resonance, and non-contamination, have emerged as a potential strategy to inactivate pathogenic viruses and have attracted increasing attention.This paper reviews the recent literature on the effects of electromagnetic waves on pathogenic viruses and their mechanisms, as well as promising applications of electromagnetic waves to inactivate pathogenic viruses, to provide new ideas and methods for this inactivation.

Journal: Virology journal (2022)
Publication types: Journal Article;Review
Effects of thermal annealing on the distribution of boron and phosphorus in p-i-n structured silicon nanocrystals embedded in silicon dioxide.

Thermal annealing temperature and time dictate the microstructure of semiconductor materials such as silicon nanocrystals (si ncs).Herein, atom probe tomography (apt) and density functional theory (dft) calculations are used to understand the thermal annealing temperature effects on si ncs grown in a si o2matrix and the distribution behaviour of boron (b) and phosphorus (p) dopant atoms.The apt results demonstrate that raising the annealing temperature promotes growth and increased p concentration of the si ncs.The data also shows that the thermal annealing does not promote the incorporation of b atoms into si ncs.Instead, b atoms tend to locate at the interface between the si ncs and si o2matrix.The dft calculations support the apt data and reveal that oxygen vacancies regulate si nc growth and dopant distribution.This study provides the detailed microstructure of p-type, intrinsic, and n-type si ncs with changing annealing temperature and highlights how b and p dopants preferentially locate with respect to the si ncs embedded in the si o2matrix with the aid of oxygen vacancies.These findings will be useful towards future optoelectronic applications.

Journal: Nanotechnology (2021)
Publication types: Journal Article
Cognitive Impairment Is Reflected by an Increased Difference between Real and Imagined Timed Up and Go Test Performance.

Recent research suggests using an imaginary version of the timed up and go test (tug) for a first assessment of cognitive impairment.By using the time difference between a real (tugr) and an imagined (tugi) tug task, the objective of this study was to examine the effect of cognitive impairment on motor imagery ability.Methods fifty-two participants (mean age 69.3 ± 4.0 years) with mild cognitive impairment or subjective cognitive impairment were included in this study.The time difference between the tugr and the tugi was used as the main outcome.The trail making test part b (tmt b), the ratio between tmt a and tmt b, and the montreal cognitive assessment (mo ca) battery were the main independent variables.Results the difference between tugr and tugi performance time and the tmt b performance time increased with decreasing cognitive function (p < 0.01).There was no relationship between tugr and tugi performance time and tmt b/a ratio.There were significant correlations between tug time differences and the mo ca score (r = -0.489, p < 0.01), the tmt b (r = 0.364, p < 0.01), and the tmt b/a ratio (r = 0.377, p < 0.01).Conclusion the combination of tugr and tugi may have added value in assessing cognitive impairment, which is a possible pre-stage of dementia.

Journal: Dementia and geriatric cognitive disorders (2017)
Publication types: Journal Article
Time-Dependent Studies of Oxaliplatin and Other Nucleolar Stress-Inducing Pt(II) Derivatives.

The properties of small molecule pt(ii) compounds that drive specific cellular responses are of interest due to their broad clinical use as chemotherapeutics as well as to provide a better mechanistic understanding of bioinorganic processes.The chemotherapeutic compound cisplatin causes cell death through dna damage, while oxaliplatin may induce cell death through inhibition of ribosome biogenesis, also referred to as nucleolar stress induction.Previous work has found a subset of oxaliplatin derivatives that cause nucleolar stress at 24 h drug treatment.Here we report that these different pt(ii) derivatives exhibit a range of rates and degrees of global nucleolar stress induction as well as inhibition of r rna transcription.Potential explanations for these variations include both the ring size and stereochemistry of the non-aquation-labile ligand.We observe that pt(ii) compounds containing a 6-membered ring show faster onset and a higher overall degree of nucleolar stress than those containing a 5-membered ring, and that compounds having the 1r,2r-stereoisomeric conformation show faster onset and a higher overall degree of stress than those having the 1s,2s-conformation.Pt(ii) cellular accumulation and cellular pt(ii)-dna adduct formation did not correlate with nucleolar stress induction, indicating that the effect is not due to global interactions.Together these results suggest that pt(ii) compounds induce nucleolar stress through a mechanism that likely involves one or a few key intermolecular interactions.

Journal: ACS chemical biology (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.;Research Support, N.I.H., Extramural
Characterizing pediatric emergency department visits during the COVID-19 pandemic.

We determine how pediatric emergency department (ed) visits changed during the covid-19 pandemic in a large sample of u.s.Eds.Methods using retrospective data from january-june 2020, compared to a similar 2019 period, we calculated weekly 2020-2019 ratios of non-covid-19 ed visits for adults and children (age 18 years or less) by age range.Outcomes were pediatric ed visit rates before and after the onset of pandemic, by age, disposition, and diagnosis.Results we included data from 2,213,828 visits to 144 eds and 4 urgent care centers in 18 u.s.States, including 7 eds in children's hospitals.During the pandemic period, adult non-covid-19 visits declined to 60% of 2019 volumes and then partially recovered but remained below 2019 levels through june 2020.Pediatric visits declined even more sharply, with peak declines through the week of april 15 of 74% for children age < 10 years and 67% for 14-17 year.Visits recovered by june to 72% for children age 14-17, but to only 50% of 2019 levels for children < age 10 years.Declines were seen across all ed types and locations, and across all diagnoses, with an especially sharp decline in non-covid-19 communicable diseases.During the pandemic period, there was 22% decline in common serious pediatric conditions, including appendicitis.Conclusion pediatric ed visits fell more sharply than adult ed visits during the covid-19 pandemic, and remained depressed through june 2020, especially for younger children.Declines were also seen for serious conditions, suggesting that parents may have avoided necessary care for their children.

Journal: The American journal of emergency medicine (2021)
Publication types: Journal Article;Observational Study
Could OX40 agonist antibody promote activation of the anti-tumor immune response in gastric cancer?

And objectives ox40, a membrane-bound molecule of the tumor-necrosis-factor-receptor superfamily, is a critical costimulatory receptor during the immune response, especially to t cells, but studies described their presence of ox-40 on neutrophils and monocytes, suggesting a potential role in the activation of immune response.Our aim was to characterize costimulatory receptors ox40 expression on circulating leukocytes in gastric cancer to identify novel targets for immunotherapy.Methods peripheral blood mononuclear cells were isolated from 24 gastric cancer patients and 34 healthy controls and the expression of costimulatory (ox40) receptors were analyzed on t cells, neutrophil and monocyte using monoclonal antibodies by flow cytometry.Results we found that the higher levels of ox40 + t cells, monocytes/ox40+ and neutrophils/ox40+ from gastric cancer patients when compared to controls (p < 0.0001), and also higher levels of ox40+ t cells when compared to stages iii and iv (p = 0.02).Percentage levels of total t cells were similar between patients and controls.Conclusions ox40 as a therapeutic agent has been investigated in many preclinical tumor models.Our findings suggest that of levels of costimulatory in t cells in gc will direct future studies on the role that costimulatory receptors play in the failure of t cell-mediated immunity.

Journal: Journal of surgical oncology (2018)
Publication types: Journal Article