syedzayyan/paper_mill_benchmark huggingface dataset:
Child Electronic Growth Monitoring System: An innovative and sustainable approach for establishing the Kaduna Infant Development (KID) Study in Nigeria.

Developing countries bear the burden of childhood stunting but lack resources for cohort studies to develop preventive strategies.To enable future prospective studies, we designed and tested the child electronic growth monitoring system (cegroms) using a readily available electronic data capture platform, the research electronic data capture (redcap).Objectives to demonstrate the feasibility of using cegroms for data collection for a pilot study for the kaduna infant development (kid) birth cohort study in nigeria.Methods cegroms consists of the data capture form for growth monitoring, a central cloud server, electronic tablets, and desktop computer.We implemented the pilot study in 2017-2019 at the barau dikko teaching hospital, kaduna, nigeria.Odds ratios (or) and 95% confidence intervals (ci) were calculated for completeness of baseline data (relative to individuals with incomplete data) and completion of follow-up at different time points (relative to individuals with no follow-up visit) by the participant characteristics.Complete data were defined as date of birth, sex, and birthweight recorded at recruitment.Results among 3152 infant records in cegroms, 2789 (88.5%) had complete data.Of these, 1905 (68.3%) had at least one follow-up visit.The main determinants of data completeness were health facility delivery (or 19.17, 95% ci 13.65, 26.92) and tertiary education (or 3.54, 95% ci 2.69, 4.67).Follow-up was greater for women with tertiary education (or 1.33, 95% ci 1.06, 1.51 for at least one visit).Maternal education is associated with completeness and follow-up (following adjustments for parity and employment).Conclusions the cegroms electronic data collection system enables complete and consistent data collection.The data will enable design of strategies to improve follow-up in the future implementation of the birth cohort study.

Journal: Paediatric and perinatal epidemiology (2020)
Publication types: Journal Article;Research Support, N.I.H., Intramural
How parental smartphone addiction affects adolescent smartphone addiction: The effect of the parent-child relationship and parental bonding.

Adolescent smartphone addiction (asa) has fueled concerns worldwide regarding the negative health effects.This study aimed to examine whether parental smartphone addiction (psa) affected asa, and evaluated the mediating role of the parent-child relationship and the moderating role of parental bonding in the effect from psa to asa, among a chinese sample of parent-child pairs.Methods a large-scale cross-sectional survey was conducted among 10- to 15-year-old students and their parents.Asa and psa were assessed by mobile phone addiction index (mpai).The parent-child relationship was evaluated by child-parent relationship scale-short form (cprs-sf), and parental bonding was estimated by parental bonding instrument (pbi).Conditional process model was used to examine the relationship between psa and asa, as well as the mediating effect of parent-child relationship and the moderating effect of parental bonding.Results a total of 9515 adolescents and their parents completed the online survey.Psa significantly positively predicted asa (b = 0.488, p 0.05).Specifically, parental overprotection had a positive moderating effect on the second half mediation path.The indirect effect of psa on asa through parent-child relationship was greater in higher overprotection than in lower.Limitations cross-sectional study of self-administrated questionnaires.Conclusions adolescents had a higher tendency toward smartphone addiction when their parents excessively used smartphones.The findings highlighted the essential role of parent-child relationship and parental bonding in the association from psa to asa.

Journal: Journal of affective disorders (2022)
Publication types: Journal Article
Efficacy and safety of rivaroxaban in patients with inferior vena cava filter placement without anticoagulation contraindications (EPICT): a prospective randomised controlled trial study protocol.

Introduction inferior vena cava (ivc) filters are commonly used in patients with venous thromboembolism to prevent fatal pulmonary embolism, but the thrombosis risk increases after filter placement.Warfarin is a widely anticoagulant, but long-term monitoring and dose adjustments are required.Anticoagulation with rivaroxaban is more straightforward as it dose not require laboratory monitoring.This study compares the efficacy and safety of rivaroxaban and warfarin as an in anticoagulation therapy for patients with ivc filter placement.Methods and analysis this is a multicentre, randomised controlled trial.In total, 200 patients with deep vein thrombosis (dvt) with ivc filter implantation from 10 hospitals will be recruited.The patients will be randomised to the experimental group (rivaroxaban) or the control group (nadroparin overlapped with warfarin).The primary outcomes include death of any cause, pulmonary embolism (pe)-related death, bleeding and recurrent pe/dvt.The secondary outcomes include the percentage of other vascular events, ivc filter retrieval failure and net clinical benefits.This study aims to provide reliable, verification for the efficacy and safety of rivaroxaban antithrombotic therapy after ivc filter placement.Ethics and dissemination the study was approved by the human research ethics committee of the second affiliated hospital of zhejiang university school of medicine (approval number: (2019) 295).The results will be disseminated through presentations at scientific conferences and publications in peer-reviewed journals trial registration number: nct04066764.

Journal: BMJ open (2021)
Publication types: Clinical Trial Protocol;Journal Article;Research Support, Non-U.S. Gov't
Effects of a 6-Month Multifaceted Diet and Exercise Intervention on Cognition in Older Adults at Risk of Cognitive Decline: The PONDER Double-Blind, Placebo-Controlled Randomized Trial.

Multidomain interventions which incorporate exercise and dietary supplementation to target both cognitive and physical health domains may be an important approach to delay cognitive decline.Objective the protein omega-3 a nd vitamin d exercise research (ponder) study investigated the effects of a 6-month multifaceted intervention in community-dwelling older adults with subjective memory impairment on cognition (primary outcome), physical function, and body composition with a further 6-month follow up for cognition (secondary outcomes).Methods single-center, community-based, parallel-group, randomized, double-blind placebo-controlled trial involving a 6-month multifaceted intervention with a further follow-up at 12 months.A total of 147 participants [mean age 70.2 years (sd 6.1), 70% female] were randomized to a multimodal exercise program consisting of twice-weekly supervised resistance and aerobic training, combined with a daily omega-3 (900 mg epa, 600 mg dha), vitamin d (1000 iu) and protein (20 g) supplement (n = 73), or a control condition (n = 74) comprising stretching/flexibility sessions combined with a placebo.The primary outcome was a composite cog state measure and trail-making test b-a.Results there were no significant between-group differences in the change of cognition at 6 or 12 months or physical function outcomes at 6 months, but the intervention significantly improved total lean mass compared to controls [0.72 kg (95% ci 0.26-1.19), p = 0.001].Conclusion a multi-faceted intervention including an omega-3, vitamin d and protein-enriched supplement with twice-weekly exercise training did not provide any benefits to cognitive or physical function in older adults with subjective memory impairment, despite improvements in lean mass.

Journal: Journal of Alzheimer's disease : JAD (2022)
Publication types: Journal Article;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
Preexposure Prophylaxis for HIV Prevention in a Rural Southern Clinic.

S little is known about implementing preexposure prophylaxis (pr ep) for human immunodeficiency virus (hiv) in the rural us south, where most hiv infections occur.To investigate how to better reach the at-risk population in rural eastern north carolina (enc), the characteristics and clinical courses of those receiving pr ep from our clinic were reviewed and analyzed.Methods a retrospective study was used to describe the characteristics and outcomes of pr ep participants in rural enc.Results thirty-five patients were included whose median age was 37 years (range 22-69).The majority of patients tolerated pr ep well and continued the medication, with only 6 (17%) discontinuations; the reasons for discontinuing included partner mistrust, intolerance to medication, and pregnancy.Patients who initiated pr ep in enc were more likely to be insured (89%), white (66%), and male (69%).Average travel time to the clinic was 34 minutes (range 2-123 minutes) and the average travel distance was 23 mi (range 1-93 mi).Conclusions the study results were noteworthy given that in north carolina, young black men have the highest estimated rates of hiv infection.The reasons behind this discrepancy are likely multifactorial, and this study highlights the need for future programs and research to make pr ep more widely accessible to the at-risk population in this rural enc community.

Journal: Southern medical journal (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Fluroine-18 fluorodeoxyglucose-positron emission tomography/computer tomography in staging of renal cell carcinoma arising from a native kidney with liver and bone metastasis in a renal transplant patient.

Renal cell carcinoma (rcc) of the native kidney accounts for <5% of all malignancies found in transplant recipients.There have been only a few reported cases comprising of few renal transplant patients with rcc of native kidneys due to the relative rarity of the condition.Fluorine-18 fluorodeoxyglucose (fdg)-positron emission tomography (pet)/computed tomography (ct) is used in the staging of rcc.Prognosis of metastatic rcc is poor.We report the first case of 55-year-old postrenal transplant recipient diagnosed with rcc of the native kidney with liver and bone metastases imaged using f-18 fdg pet/ct.

Journal: World journal of nuclear medicine (2018)
Publication types: Case Reports;Journal Article
Exposure of Anopheles gambiae larvae to a sub-lethal dose of an agrochemical mixture induces tolerance to adulticides used in vector control management.

The heavy use of pesticides in agricultural areas often leads to the contamination of nearby mosquito larvae breeding sites.Exposure to complex mixtures of agrochemicals can affect the insecticide sensitivity of mosquito larvae.Our study objective was to determine whether agrochemical residues in anopheline larval breeding sites can affect the tolerance of adults to commonly used adulticides.We focussed on fludora® fusion, a vector control insecticide formulation combining two insecticides (deltamethrin and clothianidin) with different modes of action.An.Gambiae larvae were exposed to a sub-lethal dose of a mixture of agrochemical pesticides used in a highly active agricultural area on the ivory coast.Comparative bioassays with fludora fusion mixture and its two insecticide components (deltamethrin and clothianidin) were carried out between adult mosquitoes exposed or not to the agrochemicals at the larval stage.A transcriptomic analysis using rna sequencing was then performed on larvae and adults to study the molecular mechanisms underlying the phenotypic changes observed.Bioassays revealed a significantly increased tolerance of adult females to clothianidin (2.5-fold) and fludora fusion mixture (2.2-fold) following larval exposure to agrochemicals.Significantly increased tolerance to deltamethrin was not observed suggesting that insecticide exposure affects the adult efficacy of the fludora fusion mixture mainly through mechanisms acting on clothianidin.Transcriptomic analysis revealed the potential of agrochemicals to induce various resistance mechanisms including cuticle proteins, detoxification action and altered insecticide sequestration.These results suggest that although the fludora fusion mixture is effective for adult vector control, its efficacy may be locally affected by the ecological context.The present study also suggests that, although the complex interactions between the use of agrochemicals and vector control insecticides are difficult to decipher in the field, they still must be considered in the context of insecticide resistance management programmes.

Journal: Aquatic toxicology (Amsterdam, Netherlands) (2022)
Publication types: Journal Article
Dexamethasone enhances the antitumor efficacy of Gemcitabine by glucocorticoid receptor signaling.

Gemcitabine (gem) is currently used as the first-line therapy for liver and pancreatic cancer but has limited efficacy in most cases.Dexamethasone (dex) have been applied as a chemoprotectant and chemosensitizer in cancer chemotherapy.This study further explored the potential of combination of gem and dex and tested the hypothesis that glucocorticoid receptor signaling is essential for the synergistic antitumor activity.In the hep g2 and as pc-1 xenograft models, the combination treatment showed a significantly synergistic antitumor activity.Immunohistochemistry of post-treatment tumors showed a significant decrease in proliferation and angiogenesis as compared to either of the treatments alone.Dex alone and the combination with gem inhibited the expression of glucocorticoid receptor.The combination of dex and gem showed synergistic cytotoxicity in cell linesin vitro.The antiproliferative synergism is prevented by used glucocorticoid receptor (gr) small interfering rna, demonstrating that the glucocorticoid receptor is required for the antiproliferative synergism of gem and dex.The inhibition of glucocorticoid receptor signaling pathway and induction of apoptosis via activation of caspases 3, 8 and 9, parp, contributed to the synergistic effect of this combination therapy.These results demonstrate that dex could potentiate the antitumor efficacy of gem.The synergistic antitumor activity of the combination of dex and gem was through glucocorticoid receptor signaling.Taken together, a combination of dex and gem shows a significant synergistic antitumor activity and lesser toxicity bothin vitroandin vivoand could be a combination chemotherapy for the treatment of highly expression of glucocorticoid receptor patients.

Journal: Cancer biology & therapy (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Anomaly detection using edge computing in video surveillance system: review.

The current concept of smart cities influences urban planners and researchers to provide modern, secured and sustainable infrastructure and gives a decent quality of life to its residents.To fulfill this need, video surveillance cameras have been deployed to enhance the safety and well-being of the citizens.Despite technical developments in modern science, abnormal event detection in surveillance video systems is challenging and requires exhaustive human efforts.In this paper, we focus on evolution of anomaly detection followed by survey of various methodologies developed to detect anomalies in intelligent video surveillance.Further, we revisit the surveys on anomaly detection in the last decade.We then present a systematic categorization of methodologies for anomaly detection.As the notion of anomaly depends on context, we identify different objects-of-interest and publicly available datasets in anomaly detection.Since anomaly detection is a time-critical application of computer vision, we explore the anomaly detection using edge devices and approaches explicitly designed for them.The confluence of edge computing and anomaly detection for real-time and intelligent surveillance applications is also explored.Further, we discuss the challenges and opportunities involved in anomaly detection using the edge devices.

Journal: International journal of multimedia information retrieval (2022)
Publication types: Journal Article;Review
Endothelial cells: potential novel regulators of renal inflammation.

Substantial evidence has supported the role of endothelial cell (ec) activation and dysfunction in the development of hypertension, chronic kidney disease (ckd), and lupus nephritis (ln).In both humans and experimental models of hypertension, ckd, and ln, ecs become activated and release potent mediators of inflammation including cytokines, chemokines, and reactive oxygen species that cause ec dysfunction, tissue damage, and fibrosis.Factors that activate the endothelium include inflammatory cytokines, mechanical stretch, and pathological shear stress.These signals can activate the endothelium to promote upregulation of adhesion molecules, such as intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, which promote leukocyte adhesion and migration to the activated endothelium.More importantly, it is now recognized that some of these signals may in turn promote endothelial antigen presentation through major histocompatibility complex ii.In this review, we will consider in-depth mechanisms of endothelial activation and the novel mechanism of endothelial antigen presentation.Moreover, we will discuss these proinflammatory events in renal pathologies and consider possible new therapeutic approaches to limit the untoward effects of endothelial inflammation in hypertension, ckd, and ln.

Journal: American journal of physiology. Renal physiology (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.;Review
Simply effective? The differential effects of solution-focused and problem-focused coaching questions in a self-coaching writing exercise.

Coaching is a systematic and goal-oriented one-on-one intervention by a coach aimed to guide clients in their professional and personal development.Previous research on coaching has demonstrated effects on a number of positive outcomes, including well-being and performance, yet little is known about the processes that underlie these outcomes, such as the type of questions coaches use.Here, we focus on three different types of coaching questions, and aim to uncover their immediate and sustained effects for affect, self-efficacy, and goal-directed outcomes, using a between-subjects experiment.One hundred and eighty-three medical residents and ph d students from various medical centers and healthcare organizations in the netherlands were recruited to participate in a self-coaching writing exercise, where they followed written instructions rather than interacting with a real coach.All participants were randomly allocated to one of three conditions: either one of two solution-focused coaching conditions (i.e., the success or miracle condition) or a problem-focused coaching condition.Self-report questionnaires were used to measure key outcomes of coaching, that is positive and negative affect, self-efficacy, goal orientation, action planning (i.e., quantity and quality) and goal attainment.Two follow-up measurements assessed if the effects of the self-coaching exercise led to problem-solving actions within an initial follow-up period of 14 days and a subsequent follow-up period of 10 days.Findings showed that participants experienced more positive affect, less negative affect, and higher approach goal orientation after the solution-focused coaching exercise compared to the problem-focused coaching exercise.In all conditions, goal attainment increased as a consequence of the self-coaching intervention.We discuss the implications of our findings for the science and practice of contemporary coaching.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article
Markers to sensibility and relapse on IMR-32 neuroblastoma cell line cultured in monolayer (2D) and neurosphere (3D) models cisplatin-treated.

The complexity of different components of tumor stroma poses huge challenges for therapies targeting the neuroblastoma (nb) microenvironment.The present study aimed to evaluate platinum-based response in imr-32 neuroblastoma cell line cultured in monolayer (2d) and neurosphere (3d) models.For this, we evaluated m rna expression of heat shock proteins hspa1a, hspb1, trap1, hspa1al, hspd1, and dna damage repair gene ercc1.After treatment, residual cells were grafted on cam (chicken chorioallantoic membrane) to evaluate the growth capability and histological paraffin sections were made to assess ki-67 and her-2 proteins by immunofluorescence.Our results showed that cisplatin induces m rna downregulation of heat shock proteins and ercc1 in imr-32 cells cultured in 2d or 3d models.In addition, the cisplatin-treatment approach increased her-2 expression in residual imr-32 cells grafted on the cam.Therefore, these insights provide many advances in neuroendocrine tumor biology and knowledge about cisplatin-response in neuroblastoma.

Journal: Acta histochemica (2022)
Publication types: Journal Article
Serum collectrin levels in patients with early- and late-onset preeclampsia.

The aim of this study is to investigate the maternal levels of collectrin in early-onset preeclampsia (eope) and late-onset preeclampsia (lope).To assess the correlation between serum collectrin levels and blood pressure in humans.Material and methods this cross-sectional study was conducted including 79 pregnant women, 27 with normal pregnancy, 30 with eope and 22 with lope.Maternal serum levels of collectrin were measured by using enzyme-linked immunosorbent assay kits.Results the mean serum collectrin level was significantly lower in women with pe compared with the control group (8.49 ± 3.12 ng/ml (eope), 9.69 ± 3.01 ng/ml (lope) versus 11.51 ± 4.33 ng/ml) and was found to be the lowest in the eope group (8.49 ± 3.12 ng/ml).The mean serum urea and uric acid levels were significantly higher in the pe group than the control group.Serum collectrin concentrations did not correlate with maternal age, bmi and serum creatinine levels.However, collectrin concentrations were negatively correlated with systolic blood pressure (r = -0.284, p = .011) and diastolic blood pressure (r = -0.275, p = .014) as well as with maternal serum urea (r = -0.269, p = .017) and uric acid (r = -0.219, p = .049) concentrations.Conclusion maternal serum collectrin levels are significantly lower in patients with preeclampsia than in the control group.There is an inverse correlation between serum collectrin levels and blood pressure.

Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2018)
Publication types: Journal Article