syedzayyan/paper_mill_benchmark huggingface dataset:
Study on the Clinical Value of Noninvasive Prenatal Testing in Screening the Chromosomal Abnormalities of the Fetus in the Elderly Pregnant Women

Introduction.To explore the clinical value of noninvasive prenatal testing (nipt) in screening the chromosomal abnormalities of the fetus in the elderly pregnant women.Materials and methods.Between january 2020 and december 2021, 1949 elderly pregnant women underwent nipt in our hospital.At the same time, 236 elderly pregnant women received invasive prenatal diagnosis, and the pregnancy outcomes were followed-up.Results.When nipt was used for prenatal screening of fetal chromosomal aneuploidy, its diagnostic coincidence rate for trisomy 21 was the highest, with a coincidence rate of 90.00%, and the diagnostic coincidence rate for other chromosomal abnormalities was the lowest, only 22.22%.The sensitivity, specificity, positive predictive rate, and negative predictive rate for t21 by nipt were 100%, 99.97%, 94.28%, and 100%; for t18 were 100%, 99.92%, 72.22%, and 100%, respectively; and for t13 were 100%, 99.95%, 50%, and 100%, respectively.Patients with high risks according to nipt results further received invasive prenatal diagnosis, and 18 cases were excluded from the follow-up.For the remaining 1933 cases in the nipt group, there was an incidence of 2.28% of adverse pregnancy outcomes.For the remaining 234 cases in the amniocentesis group, there was an incidence of 1.28% of adverse pregnancy outcomes.There was no significant difference between the two groups ( p &gt; 0.05 ).The diagnostic rate of fetal chromosomal abnormalities in pregnant women under 40 years old was about 0.39-0.79%; however, the risk for people over 40 is relatively high at 1.32-4.44%.Conclusion.The noninvasive prenatal screening of fetal dna in the second trimester of pregnancy for elderly pregnant women has high application value in the prediction of pregnancy outcome.The high risk of pregnancy can be determined by detecting trisomy 21, 18, and 13 syndromes, and the probability of adverse pregnancy outcome increases.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Study on Control of Risks Existing in the Construction of Information Management System in Public Hospitals

In terms of the medical information management system, it can effectively increase the resource utilization rate of medical and health institutions, optimize the management process, and provide relevant, efficient management approaches, all of which help medical and health institutions meet their internal and external demands to the greatest possible extent.However, the projects related to the information management system in hospitals or other medical institutions are characterized by high system complexity, multiple related links, and uncertainty of project demands due to their own professional and industrial characteristics, which are frequently manifested as many limiting factors in the construction process.It is essential to determine the kind of risk and evaluation methods to explore the risk evaluation indicators and formulate corresponding countermeasures for ongoing medical institution information systems projects.In such a background, this study establishes a perfect risk identification and evaluation system by taking the risk management of projects related to medical institution information system in r hospital as the research object and proposes the corresponding countermeasures as the reference for the establishment of the information management system.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Stretching Training Rehabilitation Has Potential to Alleviate Ankylosing Spondylitis in Mice by Inactivating the Wnt/β-Catenin Pathway

Ankylosing spondylitis (as) is a chronic inflammatory disease characterized by invasion of the joints of the central axis that involves soft tissues and joints surrounding the spine.Stretching training rehabilitation (str) has been widely applied for the treatment of as.The wnt/β-catenin signalling pathway is closely related to as.In this study, we aimed to explore the potential molecular mechanisms underlying the protective effect of str on as both in vitro and in vivo.Male dba/1 mice were employed to establish an as animal model.Hematoxylin-eosin staining showed that str reversed pathological damages in bone tissues and the total antioxidant capacity of as mice and increased the antioxidant capacity by upregulating superoxide dismutase and malondialdehyde expression in dba/1 mice.The mtt, rt-q pcr, and western blotting results further indicated that str improved the survival rate of cells by downregulating the expression of target genes in the wnt/β-catenin pathway and by inhibiting cell inflammation and apoptosis.In conclusion, our findings indicated that str treatment might be an effective therapeutical strategy for as.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Stressors of Nursing Interns and Their Influencing Factors: A Cross-Sectional Study

It is still unknown whether the stress level and stressors in chinese nursing interns are influenced by teacher-related factors.This research was carried out for better understanding of the stress in nursing interns and distribution of stressors during their clinical practice and targeted measures to unwind the stress of nursing interns.Methods.A questionnaire survey, titled questionnaire on stressors of nursing interns during clinical practice, was conducted on nursing interns at a 3a grade hospital in shandong province.Characteristics of the nursing interns and stressors of nursing interns were collected.A multiple-linear regression model was used to explore the influencing factors of nursing interns’ scores.Results.A total of 132 nursing interns were investigated in this study, and the overall stress scores were calculated.The stressors during the internship include the nature and content of the job, role orientation, workload, conflict between study and work, practice preparation, and interpersonal relationships.Gender, education level, instructor encouragement, and parents engaged in the medical industry were adjusted in the multiple-linear regression model as covariates.All of these factors had significant impacts on the scores of stressors ( p &lt; 0.05), with the partial regression coefficient values of 13.38, −10.52, −5.02, 3.4, −9.89, −14.77, and −15.83 for factors like female, undergraduates, graduate students, never obtained encouragement from teachers, obtained encouragement from teachers occasionally, obtained encouragement from teachers frequently, and parents engaged in the medical industry, respectively.Conclusion.The stressors of nursing interns are mostly work-wise, and teachers’ encouragement is an important protective factor for nursing interns to reduce stress.Therefore, clinical instructors should take targeted measures in teaching methods and work arrangements according to the needs of interns.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Strategies of Bioceramics, Bioactive Glasses in Endodontics: Future Perspectives of Restorative Dentistry

Prevalently, there is a primary strategy to cure caries using restorative materials notably bioceramics.Existing synthetic materials stimulate natural tooth structure with acceptable interfacial bonding and esthetic and biomechanical qualities with better durability.Several bioceramics have been introduced and investigated for their potentialities as restorative materials.Biomineralization of tooth initiates repair and regeneration of natural dental tissue and reinstating the integrity of periodontium.In the evolution of bioceramics in the aspects of different essential composition for dental application, recent technology and modern strategies revolutionize the restorative dentistry.Bioglass is one among the important bioceramics as a restorative material, and by regulating the properties of the material, it is possible to construct improved formulation towards restoration.This article reviews the current revolution of endodontics, existing restorative materials, and technologies to be achieve for engineering materials with the better design.

Journal: BioMed Research International (2022)
Publication types: Review Article;
Software Defined Network Enabled Fog-to-Things Hybrid Deep Learning Driven Cyber Threat Detection System

Software defined network (sdn) is a next-generation networking architecture and its power lies in centralized control intelligence.The control plane of sdn can be extended to many underlying networks such as fog to internet of things (io t).The fog-to-io t is currently a promising architecture to manage a real-time large amount of data.However, most of the fog-to-io t devices are resource-constrained and devices are widespread that can be potentially targeted with cyber-attacks.The evolving cyber-attacks are still an arresting challenge in the fog-to-io t environment such as denial of service (do s), distributed denial of service (ddo s), infiltration, malware, and botnets attacks.They can target varied fog-to-io t agents and the whole network of organizations.The authors propose a deep learning (dl) driven sdn-enabled architecture for sophisticated cyber-attacks detection in fog-to-io t environment to identify new attacks targeting io t devices as well as other threats.The extensive simulations have been carried out using various dl algorithms and current state-of-the-art coburg intrusion detection data set (cidds-001) flow-based dataset.For better analysis five dl models are compared including constructed hybrid dl models to distinguish the dl model with the best performance.The results show that proposed long short-term memory (lstm) hybrid model outperforms other dl models in terms of detection accuracy and response time.To show unbiased results 10-fold cross-validation is performed.The proposed framework is so effective that it can detect several types of cyber-attacks with 99.92% accuracy rate in multiclass classification.

Journal: Security and Communication Networks (2021)
Publication types: Research Article;
Social Support as a Mediator of the Relationship between Hope and Decisional Conflict in Patients Deciding Whether to Receive Dialysis

The incidence rate of end-stage renal disease (esrd) in taiwan is the highest worldwide.Patients often hesitate and feel helpless when deciding whether to receive dialysis.However, the resulting delay in starting dialysis can potentially threaten patients’ lives.Purpose.This study aimed to understand the current situation and correlations between hope, social support, and decisional conflict among patients with esrd deciding whether to receive dialysis.In addition, the role of social support as a mediating variable of the relationship between hope and decisional conflict was investigated.Methods.This study was a cross-sectional, descriptive correlation study.Data, including demographic information, were collected from 85 patients with esrd who were deciding whether to receive dialysis.Research tools included the chinese versions of the herth hope index, the interpersonal support evaluation list, and the decisional conflict scale.Results.When deciding whether to receive dialysis, patients with esrd felt a low sense of hope, a moderate degree of social support, and a moderate degree of decisional conflict.Hope was significantly correlated with social support and decisional conflict.Social support demonstrated a full mediating effect of 47.7% ( p &lt; 0.001 ).Conclusions.Patients with esrd facing the decision to receive dialysis felt a low sense of hope and exhibited decisional conflict.Social support was found to be a mediating variable of the relationship between hope and decisional conflict; therefore, medical personnel should increase the social support of patients with esrd who are deciding whether to commence dialysis to promote patients’ hope and reduce their decisional conflict.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Sports Risk Analysis Based on Knowledge Discovery and Data Driven

Sports have gradually gained popularity, and the risks associated with them have risen as well.In today’s world, college students are a diverse population, and sports are very popular among them.The construction of sports risk assessment system in ordinary colleges is significant to improve physical quality of college students and ensure safety.College sports accidents have occurred on occasion in recent years, causing not only enormous pain to students and parents, but also casting a dark shadow over the sport.This work takes the risk analysis of college students’ sports as the background, and uses a data-driven neural network to conduct knowledge discovery of college sports threats.It evaluates the sports risks of college students’ physical education, and builds an index system of sports risk assessment in ordinary colleges and universities, which provides a certain basis for avoiding and reducing sports risks.This work studies an end-to-end one-dimensional convolutional neural network algorithm for risk assessment of college sports.In order to extract complementary structures in different scales, a multi-scale fusion framework is constructed using convolution kernels of diverse sizes.In this paper, the residual network structure is introduced to deepen and improve the network, and an attention module suitable for one-dimensional residual network is designed.It is embedded into the residual module to construct a multi-scale attention residual network (msar) model.Finally, validity and superiority of proposed model are verified by experimental data, which can effectively evaluate the sports risk of college students.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Single-Cell Transcriptome Analysis Reveals the Importance of IRF1/FSTL1 in Synovial Fibroblast Subsets for the Development of Rheumatoid Arthritis

S.This study aimed to investigate the potential role of synovial fibroblasts (sfs) in the development of rheumatoid arthritis (ra) to identify potential molecular targets and provide a theoretical basis for the treatment of ra.Methods.Gse109449, a fibroblast transcriptome dataset of synovial tissue from ra and osteoarthritis (oa), were obtained from the geo database.After standard cell quality control, this single-cell transcriptome data was used to perform routine single-cell analysis processes.After completing dimensionality reduction, clustering, and cell subset identification of fibroblasts, the scenic analysis helped calculate the significant gene regulatory networks in fibroblasts and their subsets.From these computed gene regulatory networks, the regulon in which follistatin-like protein 1 (fstl1) resides was extracted and used to analyze the transcriptional regulatory status of fibroblasts.Finally, the gene set enrichment analysis (gsea) was used to calculate the respective enriched gene sets of irf1 and fstl1.Results.Three sf subgroups were identified from the single-cell transcriptome analysis; sf subset 3 was more abundant in ra than in oa ( p &lt; 0.001 ).From the scenic analysis, we obtained 269 regulons and the corresponding gene regulatory networks in sf from the ra datasets.Next, we screened and obtained a regulon-containing fstl1, where irf1 was the major transcription factor.The top five regulons in sf subset 3 were twist1, mecom, klf6, mafb, and runx1.Among the 3 sf subsets, irf1 regulon was ranked the highest in sf subset 3.Differential analysis of pseudobulk rna-seq showed that irf1 was up-regulated in ra compared to oa.Between the three sf subgroups, irf1 and fstl1 expression was more up-regulated in sf subset 3 compared to the other two subgroups.Conclusions.Irf1 was found to regulate the invasiveness of sfs by regulating fstl1, which may influence the disease progression of ra.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Simvastatin in the Treatment of Colorectal Cancer: A Review

Drug repositioning and drug reuse are the heated topics in the field of oncology in recent years.These two concepts refer to seeking effective drugs for cancer that are not originally intended to treat cancer.The survival benefits are then analyzed by combining the re-positioned drugs with conventional cancer treatment methods.Simvastatin is a clinically commonly used hyperlipidemia drug and exerts the effect of preventing cardiovascular diseases.Recent studies have found that simvastatin has great potential in the treatment of colorectal cancer, and a large number of clinical studies have used simvastatin as an adjuvant drug to help treat metastatic colorectal cancer.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Review Article;
Silencing lncRNA 93358 Inhibits the Apoptosis of Myocardial Cells in Myocardial Infarction Rats by Inducing the Expression of SLC8A1

To explore the inhibitor effects and mechanism of lnc rna 93358 against the apoptosis of myocardial cells in rats with myocardial infarction.Methods .The myocardial infarction model was established in rats, which were identified by cardiac ultrasound.Ttc staining was used to evaluate the degree of heart infarction, and he staining was utilized to determine the pathological state in myocardial tissues.The apoptotic state in myocardial tissues was confirmed by tunel assay.Lnc rna 93358 was screened out using a high‐throughput sequencing which was confirmed by rt‐q pcr.The interaction between mi r‐466c‐3p and slc8a1 was identified using the dual‐luciferase reporter assay.The expression level of bax, bcl‐2, and slc8a1 was determined in lnc rna 93358 knockdown cells using rt‐q pcr and western blotting results .Massive myocardial necrosis was observed in model rats according to the results of ttc staining, he staining, and tunel assay.Lnc rna 93358 and bax were found significantly upregulated, and bcl‐2 and slc8a1 were greatly downregulated in model rats, which were dramatically reversed by the knockdown of lnc rna 93358, accompanied by the decline area of myocardial necrosis and decreased apoptotic myocardial cells.Conclusion .Silencing lnc rna 93358 inhibits the apoptosis of myocardial cells in rats with myocardial infarction by inducing the expression of slc8a1.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Shared Molecular Mechanisms between Atherosclerosis and Periodontitis by Analyzing the Transcriptomic Alterations of Peripheral Blood Monocytes

This study investigated the nature of shared transcriptomic alterations in pbms from periodontitis and atherosclerosis to unravel molecular mechanisms underpinning their association.Methods.Gene expression data from pbms from patients with periodontitis and those with atherosclerosis were each downloaded from the geo database.Differentially expressed genes (degs) in periodontitis and atherosclerosis were identified through differential gene expression analysis.The disease-related known genes related to periodontitis and atherosclerosis each were downloaded from the dis ge net database.A venn diagram was constructed to identify crosstalk genes from four categories: degs expressed in periodontitis, periodontitis-related known genes, degs expressed in atherosclerosis, and atherosclerosis-related known genes.A weighted gene coexpression network analysis (wgcna) was performed to identify significant coexpression modules, and then, coexpressed gene interaction networks belonging to each significant module were constructed to identify the core crosstalk genes.Results.Functional enrichment analysis of significant modules obtained by wgcna analysis showed that several pathways might play the critical crosstalk role in linking both diseases, including bacterial invasion of epithelial cells, platelet activation, and mitogen-activated protein kinases (mapk) signaling.By constructing the gene interaction network of significant modules, the core crosstalk genes in each module were identified and included: for gse23746 dataset, rasgrp2 in the blue module and vamp7 and snx3 in the green module, as well as hmgb1 and sumo1 in the turquoise module were identified; for gse61490 dataset, sec61g, psmb2, selplg, and fibp in the turquoise module were identified.Conclusion.Exploration of available transcriptomic datasets revealed core crosstalk genes (rasgrp2, vamp7, snx3, hmgb1, sumo1, sec61g, psmb2, selplg, and fibp) and significant pathways (bacterial invasion of epithelial cells, platelet activation, and mapk signaling) as top candidate molecular linkage mechanisms between atherosclerosis and periodontitis.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
Serum Expression of ESM-1, HMWA, and AGEs and Its Relationship with Disease Severity in Patients with Gestational Hypertension

The research is to investigate the expression and the relationship between serum endothelial cell-specific molecular molecule-1 (esm-1), high molecular weight adiponectin (hmwa), and late glycosylation terminal product (ages) in patients with gestational hypertension.Methods.75 patients with pregnant hypertension who were treated in our hospital from june 2019 to june 2020 were selected as the case group, and 70 healthy pregnant women with pregnancy examination at the same period in our hospital were selected as the control group to analyze the changes in serum esm-1, hmwa, and ages levels and the correlation with the degree of illness and their predictive value.Results.Serum esm-1 and ages were significantly higher in the case group than in the control group.Serum hmwa was significantly lower than that in the control group ( p &lt; 0.05 ).The gestational hypertensive serum esm-1 and ages was significantly lower than in patients with mild preeclampsia and severe preeclampsia.Serum hmwa was significantly higher than in patients with mild preeclampsia and severe preeclampsia.Serum esm-1 and ages of mild preeclampsia were significantly lower than in patients with severe preeclampsia.Serum hmwa was significantly higher than in patients with severe preeclampsia ( p &lt; 0.05 ).The result of correlation analysis shows a positive correlation between serum esm-1 and ages ( p &lt; 0.05 ).A negative correlation was observed between hmwa and the degree of illness ( p &lt; 0.05 ).Conclusion.Serum esm-1, hmwa, and ages are abnormally expressed in gestational hypertension, are closely related to the degree of condition, and have important clinical significance for condition control.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;