syedzayyan/paper_mill_benchmark huggingface dataset:
The role of laparoscopic sleeve gastrectomy on inflammatory parameters in morbidly obese patients.

Obesity is an excessive increase in body fat mass and triggers chronic inflammation which causes increased fat accumulation in the visceral fat tissue.The aim of this study was to analyze serum zinc (zn), zn-alpha 2 glycoprotein (zag), peroxisome proliferator-activated receptor-γ (ppar-γ) and nuclear factor kappa-light-chain-enhancer of activated b cell (nf-κb) levels in morbidly obese patients before and after laparoscopic sleeve gastrectomy (lsg) and determine the association between alteration in body mass index (bmi), the % excess weight loss (% ewl) and the biochemical parameters.Methods thirty healthy individuals as a control group and 30 morbidly obese patients who had undergone lsg were enrolled in this study.Routine anthropometric and laboratory biochemical parameters in venous blood samples of groups at baseline and 1 and 12 months after lsg were recorded.Results significant weight loss was achieved at 1 and 12 months after lsg.At baseline serum zag and ppar-γ levels were lower, while nf-кb levels were higher in morbidly obese patients compared with the control group.Serum zag and ppar-γ levels increased while nf-кb levels decreased 1 month and 12 months after lsg.Decreased %ewl was negatively correlated with changes in nf-кb, homeostatic model assessment for insulin resistance (homa-ir), fasting plasma glucose and insulin at 12 months after lsg in morbidly obese patients.However, %ewl was positively correlated with changes in zag.Conclusions obesity was associated with down-regulated serum zag and ppar-γ levels while up-regulated serum nf-кb.Our findings suggest that lsg ameliorates upregulating ppar-γ expression, thereby inhibiting nf-κb-mediated inflammation by weight loss.

Journal: Journal of visceral surgery (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Novel Aporphine- and Proaporphine-Clerodane Hybrids Identified from the Barks of TaiwanesePolyalthia longifolia(Sonn.) Thwaites var.pendulawith Strong Anti-DENV2 Activity.

Hybrid natural products produced via mixed biosynthetic pathways are unique and often surprise one with unexpected medicinal properties in addition to their fascinating structural complexity/diversity.In view of chemical structures, hybridization is a way of diversifying natural products usually through dimerization of two similar or dissimilar subcomponents through a c-c or n-c covalent linkage.Here, we report four structurally attractive diterpene-alkaloid conjugates polyalongarins a-d (1-4), clerodane-containing aporphine and proaporphine alkaloids, the first of its kind from the barks of taiwanese polyalthia longifolia(sonn.) thwaites var.pendula.In addition to conventional spectroscopic analysis, single crystal x-ray crystallography was employed to determine the chemical structures and stereo-configurations of1.Compounds1-4were subsequently subjected to in vitro antiviral examination against denv2 by evaluating the expression level of the ns2b protein in denv2-infected huh-7 cells.These compounds display encouraging anti-denv2 activity with superb ec50(2.8-6.4 μm) and cc50values (50.4-200 μm).The inhibitory mechanism of1-4on ns2b was further explored drawing on in-silico molecular docking analysis.Based on calculated binding affinities and predicted interactions between the functional groups of1-4and the allosteric-site residues of the denv2 ns2b-ns3 protease, our analysis concludes that the clerodane-aporphine/proaporphine-type hybrids are novel and effective denv ns2b-ns3 protease inhibitors.

Journal: Pharmaceuticals (Basel, Switzerland) (2022)
Publication types: Journal Article
Prediction of adverse effects of effluents containing phenolic compounds in the Ba River on the ovary of fish (Hemiculter leucisculus) using transcriptomic and metabolomic analyses.

The aim of this work was to evaluate the endocrine disrupting effects on the ovarian development of sharpbelly (hemiculter leucisculus) caused by effluents containing phenolic compounds.This was achieved using integrated transcriptomic and metabolomic analyses, along with histopathological examinations.Sharpbelly, an indigenous freshwater fish widely distributed in east asia, were collected by pole fishing from three sampling sites in the ba river.These sampling sites include a mid-stream site near a wastewater outfall and a reference site located upstream and a far field comparison site located downstream.In sharpbelly collected near the wastewater discharge, the oocyte development was activated, compared to the other two sites.Histopathological alterations in the fish ovaries were likely due to the upregulated steroid hormone biosynthesis process, as suggested by the differentially expressed genes (e.g., hsd3b, hsd17b1) and differentially accumulated metabolites (e.g., pregnenolone).Additionally, under the stress of effluents containing phenolic compounds, genes related to the signaling pathways for oxidative phosphorylation and leukocyte transendothelial migration were dysregulated, suggesting the potential induction of inflammation and several ovarian diseases.Overall, these findings suggest that effluents containing phenolic compounds influence ovary development and reproductive function of female sharpbelly.Whether there is any resulting dysfunction of folliculogenesis, abnormality of ovulation, production of premature eggs and/or potential induction of ovarian cancers remains to be determined by further studies, for a better evaluation on effluents containing phenolic compounds to the fish fertility and the health of their offspring, and even the stability of the wild fish population.Notably, the integration of transcriptomics and metabolomics can complement the routine chemical analysis to comprehensively monitor the effects of wastewater treatment plant effluents on the health of wild fish.

Journal: The Science of the total environment (2021)
Publication types: Journal Article
Combination of Astrogliosis and Phosphorylated Tau for the Preclinical Diagnosis of Alzheimer Disease Using 3-Dimensional Stereotactic Surface Projection Images With 18 F-THK5351.

The alzheimer disease (ad) brain is characterized microscopically by the presence of extracellular amyloid plaques and intraneuronal neurofibrillary tangles consisting of phosphorylated tau aggregations.18 f-thk5351 is a first-generation pet tau tracer that also binds to monoamine oxidase b, which represents astrogliosis, and is useful to evaluate some non-ad neurodegenerative disorders.We examined the utility of 18 f-thk5351 in preclinical ad using 3-dimensional stereotactic surface projection images optimized for its pathological accumulation by comparison with a normal dataset.By using this 18 f-thk5351 3-dimensional stereotactic surface projection procedure, which can evaluate phosphorylated tau and neuroinflammation, we could diagnose preclinical ad effectively.

Journal: Clinical nuclear medicine (2022)
Publication types: Journal Article
Prevention of submicron aerosolized particle dispersion: evaluation of an aerosol box using a pediatric simulation model.

And aim:the splash guard cg (sg) is a barrier enclosure developed to protect healthcare workers from sars-co v-2 transmission during aerosol-generating procedures.Our objective was to evaluate the protection provided by the sg against aerosolized particles (ap), using a pediatric simulation model of spontaneous ventilation (sv) and noninvasive ventilation (niv).methods:an aerosol generator was connected to the airways of a pediatric high-fidelity manikin with a breathing simulator.Ap concentrations were measured both in sv and niv in the following conditions: with and without sg, inside and outside the sg, with and without suction applied to the device.results:in the sv simulated setting, ap peaks were lower with sg: 0.1 × 105particles/l compared to without: 1.6 × 105, only when the ports were closed and suction applied.In the niv simulated setting, ap peaks outside the sg were lower than without sg (20.5 × 105particles/l), whatever the situation, without suction (14.4 × 105particles/l), with suction and ports open or closed: 10.3 and 0.7 × 105particles/l.In sv and niv simulated settings, the ap peaks measured within the sg were much higher than the ap peaks measured without sg, even when suction was applied to the device.conclusions:the sg seems to decrease peak ap exposure in the 2 ventilation contexts, but only with closed port and suction in sv.However, high concentrations of ap remain inside even with suction and sg should be used cautiously.

Journal: Experimental lung research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Learning and memory function in young people with and without perinatal HIV in England.

Learning and memory are important for successful education and career progression.We assess these functions in young people (yp) with perinatal hiv (phiv) (with or without a previous aids-defining illness) and a comparable group of hiv-negative yp.234 phiv and 68 hiv-negative yp completed 9 tests; 5 national institutes of health (nih) toolbox tests (2 executive function, 1 speed of information processing, 2 memory); 2 hopkins verbal learning test revised (hvlt-r) (learning (l), delayed recall (r)), and 2 verbal application measures.Z-scores for each test were calculated using normative data and averaged by domain where appropriate.The effect of predictors on test scores in the three domains with the lowest z-scores were analysed using linear regression.139(59%) and 48(71%) phiv and hiv-negative yp were female, 202(86%) and 52(76%) black, and median age was 19 [17, 21] and 18 [16, 21] years respectively.55(24%) phiv had a previous center for disease control and prevention (cdc) class c aids-defining diagnosis (phiv/c).For hvlt-r, there was a trend towards phiv/c yp having the lowest mean z-scores (l -1.5 (95% ci -1.8,-1.2), r -1.7 (-2.0,-1.4)) followed by phiv without a cdc c diagnosis (l -1.3 (-1.4,-1.1), r -1.4 (-1.5,-1.2)) and then the hiv-negative group (l -1.0 (-1.3,-0.7), r -1.1 (-1.3,-0.8)); all were greater than 1 sd below the reference mean.The same trend was seen for verbal application measures; however, z-scores were within 1 sd below the reference mean.Nih toolbox tests were similar for all groups.In multivariable analyses phiv/c and black ethnicity predicted lower hvlt-r scores.Black ethnicity also predicted lower executive function scores, however each year increase in age predicted higher scores.In conclusion, cognitive performance in verbal learning and recall fell below population normative scores, and was more pronounced in phiv/c, supporting wider findings that earlier antiretroviral therapy initiation, before the occurrence of aids-defining conditions, may protect aspects of cognitive development.

Journal: PloS one (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Sex Dimorphism in the Metabolome of Metabolic Syndrome in Morbidly Obese Individuals.

Adult morbid obesity is defined as abnormal or excessive fat accumulation, mostly resulting from a long-term unhealthy lifestyle.Between 10% and 30% of people with obesity exhibit low cardiometabolic risk.The metabolic syndrome has been suggested as an indicator of obesity-related metabolic dysregulation.Although the prevalence of obesity does not seem to be sex-related and metabolic syndrome occurs at all ages, in the last few years, sex-specific differences in the pathophysiology, diagnosis, and treatment of metabolic syndrome have received attention.The aim of this study was to determine the prevalence of metabolic syndrome and its components in different sex and age groups in people with metabolic unhealthy obesity and to compare them with people with metabolic healthy obesity.We analyzed the metabolome in 1350 well-phenotyped morbidly obese individuals and showed that there is a strong sex-dependent association of metabolic syndrome with circulating metabolites.Importantly, we demonstrated that metabolic dysregulation in women and men with severe obesity and metabolic syndrome is age-dependent.The metabolic profiles from our study showed age-dependent sex differences in the impact of met s which are consistent with the cardiometabolic characterization.Although there is common ground for met s in the metabolome of severe obesity, men older than 54 are affected in a more extensive and intensive manner.These findings strongly argue for more studies aimed at unraveling the mechanisms that underlie this sex-specific metabolic dysregulation in severe obesity.Moreover, these findings suggest that women and men might benefit from differential sex and age specific interventions to prevent the adverse cardiometabolic effects of severe obesity.

Journal: Metabolites (2022)
Publication types: Journal Article
Successful electroconvulsive therapy for depression in a man with cerebral amyloid angiopathy.

Cerebral amyloid angiopathy (caa) is a condition characterised by accumulation of amyloid beta protein (aβ) in the wall of cerebral blood vessels which increases the risk of intracranial haemorrhage and contributes to cognitive impairment.We describe the case of a man around the age of 70 with 'probable' caa according to the modified boston criteria and severe depression whose depression was treated successfully with electroconvulsive therapy (ect).To the best of our knowledge, there are no earlier published reports of ect in a patient with caa.We briefly discuss possible safety measures for these patients, the impact of ect on cognition in caa and a possible influence of ect on aβ clearance.

Journal: BMJ case reports (2021)
Publication types: Case Reports;Journal Article
Study on the migration mechanisms of water-soluble agents in high-pressure rotary jetting remediation.

High-pressure rotary jetting (hprj) remediation is a recent-applied technology for in situ remediation of contaminated soils.The effectiveness of remediation depends upon the migration and distribution of the injected agents in the soil.However, the corresponding migration mechanisms have received little attention.In this study, laboratory hprj tests and numerical simulations were performed using chlorine (cl-) as a tracer to investigate the transport during hprj and the subsequent advection and diffusion.The test results showed that the hprj transported cl-into the mixing zone by eroding the sand, and the radius of the mixing zone could be reasonably predicted by the erosion model.The cl-concentration decreased linearly along the radial direction in the mixing zone.In addition, the cl-transport distance increased with the increase in nozzle diameter, jetting times, especially injection pressure, and decreased with an increasing rotation speed.The cl-concentration and radial uniformity were correlated positively with rotation speed, particularly nozzle diameter and jetting times.Numerical simulation showed that part of cl-migrated from the mixing zone to diffusion zone by advection-diffusion after rotary jetting, which contributed positively to the agent distribution distance and uniformity.The cl-migration was dominated by advection in the initial stage (30 days), while diffusion became more important thereafter.

Journal: Environmental science and pollution research international (2022)
Publication types: Journal Article
Does Atherosclerosis Have Negative Impacts on Early Adjacent Segment Degeneration After Posterior Lumbar Interbody Fusion?

Study design retrospective study.Objective to examine whether atherosclerosis has negative impacts on early adjacent segment degeneration (asd) after posterior lumbar interbody fusion using traditional trajectory pedicle screw fixation (tt-plif).Methods the subjects were 77 patients who underwent single-level tt-plif for degenerative lumbar spondylolisthesis.Using dynamic lateral radiographs of the lumbar spine before surgery and at 3 years postoperatively, early radiological asd (r-asd) was examined.Early symptomatic asd (s-asd) was diagnosed when neurologic symptoms deteriorated during postoperative 3-year follow-up and the responsible lesions adjacent to the fused segment were also confirmed on magnetic resonance imaging.According to the scoring system by kauppila et al, the abdominal aortic calcification score (aac score: a surrogate marker of systemic atherosclerosis) was assessed using preoperative lateral radiographs of the lumbar spine.Results the incidence of early r-asd was 41.6% at the suprajacent segment and 8.3% at the subjacent segment, respectively.Patients with r-asd had significantly higher aac score than those without r-asd.The incidence of early s-asd was 3.9% at the suprajacent segment and 1.4% at the subjacent segment, respectively.Patients with s-asd had higher aac score than those without s-asd, although there was no significant difference.Conclusions at 3 years after surgery, the advanced aac had significantly negative impacts on early r-asd after tt-plif.This result indicates that impaired blood flow due to atherosclerosis can aggravate degenerative changes at the adjacent segments of the lumbar spine after plif.

Journal: Global spine journal (2021)
Publication types: Journal Article
EFFECT OF RETINAL THICKNESS VARIABILITY ON VISUAL OUTCOMES AND FLUID PERSISTENCE IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: A Post Hoc Analysis of the HAWK and HARRIER Studies.

To determine the association between central subfield thickness (cst) variability and visual outcomes in eyes with neovascular age-related macular degeneration treated with anti-vascular endothelial growth factor therapies.Methods in this post hoc, treatment-agnostic analysis, patients (n = 1,752) were grouped into quartiles of increasing cst variation.The association between cst variability and best-corrected visual acuity was measured from baseline, or from the end of the loading phase, until the end of the study using a multilevel modeling for repeated-measures model.The association between cst variability and the presence of retinal fluid was also assessed.Results increased cst variability was associated with worse best-corrected visual acuity outcomes at the end of study, with a least-square mean difference in best-corrected visual acuity of 8.9 early treatment diabetic retinopathy study letters between the quartiles with the lowest and highest cst variability at the final visit.Increased variability was also associated with a higher mean fraction of visits with the presence of fluid.Conclusion more stable cst was associated with better visual outcomes at the end of treatment suggesting that cst variability may provide a more reliable prognostic marker of visual outcomes than the presence of fluid alone, with the potential to enhance the clinical care of neovascular age-related macular degeneration patients.

Journal: Retina (Philadelphia, Pa.) (2022)
Publication types: Clinical Trial, Phase III;Comparative Study;Journal Article;Multicenter Study;Randomized Controlled Trial
"Never Trust the Skin": A Rationale for Using Polydioxanone Internal Support Matrix to Minimize Scarring in Primary Mastopexy-Augmentation-An Observational Study.

The process of scar formation is complex and multi-factorial.Basic plastic surgery tenets focus on tension-free techniques to optimize aesthetic outcomes and minimize scarring.Objectives prophylactic use of a polydioxanone (pdo) internal support matrix in cosmetic mastopexy-augmentation to decrease scar burden has never before been described.Methods a high volume (n = 41) single-surgeon mastopexy-augmentation experience (s.s.k.) followed scar quality in consecutive cases from june 2020 to july 2021.A minimum of 6 months of postoperative evaluation was required to assess scar quality.Fitzpatrick scores were also evaluated and compared.All surgeries in this study were performed in the dual plane using silicone gel implants, a superior or superomedial dermal pedicle blood supply, and a wise-pattern or vertical scar.Scar quality was evaluated by photography and scored according to an internally developed scar quality scale.Results there have been no cases of hypertrophic or keloid scarring.All patients receiving mastopexy-augmentation with prophylactic pdo mesh have a favorable appearance with fine line scars, and the mean scar quality scale score across the cohort was 4.341/5.The mean fitzpatrick scale score across the cohort was 2.97, and, of the patients who scored a 5 on the scar quality index, the mean fitzpatrick scale score was 3.545.Conclusions prophylactic use of pdo internal support matrix in silicone gel mastopexy-augmentation offers further protection against poor scarring in patients across the fitzpatrick scale, with varying degrees of skin quality, and across medium to high-volume implant augmentations.Patients who received pdo prophylaxis demonstrated a better-than-average scar appearance.Level of evidence 4

Journal: Aesthetic surgery journal. Open forum (2022)
Publication types: Journal Article
Gene therapy for hearing loss.

Sensorineural hearing loss (snhl) is the most common sensory disorder.Its underlying etiologies include a broad spectrum of genetic and environmental factors that can lead to hearing loss that is congenital or late onset, stable or progressive, drug related, noise induced, age related, traumatic or post-infectious.Habilitation options typically focus on amplification using wearable or implantable devices; however exciting new gene-therapy-based strategies to restore and prevent snhl are actively under investigation.Recent proof-of-principle studies demonstrate the potential therapeutic potential of molecular agents delivered to the inner ear to ameliorate different types of snhl.Correcting or preventing underlying genetic forms of hearing loss is poised to become a reality.Herein, we review molecular therapies for hearing loss such as gene replacement, antisense oligonucleotides, rna interference and crispr-based gene editing.We discuss delivery methods, techniques and viral vectors employed for inner ear gene therapy and the advancements in this field that are paving the way for basic science research discoveries to transition to clinical trials.

Journal: Human molecular genetics (2019)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Review
Clinical feasibility, utility, and usability of the Profile of Preschool Communication: A pilot test in community settings.

This study aimed to pilot test, assess usability and utility of, and identify barriers to implementation for the profile of preschool communication (ppc) - a new data collection tool designed to support outcome monitoring in preschool speech-language programs and practice-based research.Methods .This pilot study was conducted with three sites in the ontario preschool speech and language (psl) program.Twenty-three speech-language pathologists used the ppc for all outcome monitoring assessments for 2-3-months and provided feedback about their experience using it in practice.Then, 18 of the 23 speech-language pathologists completed online surveys to rate usability and utility, and report their perceived implementation barriers and facilitators.Results .Speech-language pathologists reported difficulties completing some sections of the ppc, most notably obtaining data related to maternal education and family history of mental health concerns.Usability and utility were generally rated favorably with some items rated as neutral.Barriers to implementation included the paper format, completion time, requirement to ask personal questions, and the perception by some that data were useful for outcome monitoring but not practice.Facilitators included ease of use, an improvement over the existing tool, and the collection of data to support service planning.Conclusions .The ppc shows potential as an outcome monitoring data collection tool in preschool speech-language pathology programs.Findings will be of interest to researchers engaged in practice-based research and those interested in engaging end users to develop clinically meaningful tools.

Journal: Journal of communication disorders (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't