syedzayyan/paper_mill_benchmark huggingface dataset:
Medical students describe their wellness and how to preserve it.

Despite widespread efforts to create wellness programming in medical schools, there is a paucity of literature examining students' perception of wellness and perceptions of these programs.With the inaugural class at the arizona campus of mayo clinic alix school of medicine (mcasom-az), an opportunity arose to establish an empirically evaluated wellness curriculum that most inclusively and effectively enables medical students to flourish for years to come.The initial wellness offerings included mental health, academic success, and disability services, curriculum-embedded seminars, wellness committee driven programming, and student-proposed wellness activities.We aimed to improve the relevance and impact of medical school wellness curricula by soliciting in-depth and longitudinal perspectives of medical students themselves.As mcasom-az opened in 2017, the student body at the time of study consisted of first- and second-year medical students.Methods employing a mixed methods analysis of qualitative and longitudinal quantitative data, first- and second-year students at a mcasom-az were invited to respond to an anonymous, online year-long survey (baseline, six months and 12 months) during the 2018-2019 academic year and participate in a structured, in-depth and in-person, peer-to-peer interview about their conceptions of wellness and the mcasom-az wellness curriculum and resources.Qualitative data was coded for themes using thematic analysis strategies by independent raters.Results nearly half of eligible students completed the baseline survey,1/3 completed all 3 time-points, and 1/5 participated in an in-depth interview.Participant age, gender, and year of school were representative of the larger student body.Although individual conceptions varied, wellness was consistently highly valued.Family, academic performance, and friends emerged as most important to well-being across time-points.Academic work arose as the largest barrier to wellness.Analysis of qualitative data revealed five themes.Despite individual differences in approaches to wellness, wellbeing was interrelated to the learning environment; mandatory wellness efforts that didn't address the medical culture met with skepticism.Conclusions interview responses provided understanding and context by which to interpret questionnaire responses.Academics was critical to students' identity and wellness, while also the largest barrier.Suggested curricular improvements include restructuring academic work, seamlessly integrating wellness within coursework, and offering optional individualized approaches.

Journal: BMC medical education (2022)
Publication types: Journal Article
Prevalence of Emotional Eating in Groups of Students with Varied Diets and Physical Activity in Poland.

Emotional eating (ee) is not a separate eating disorder, but rather a type of behavior within a group of various eating behaviors that are influenced by habits, stress, emotions, and individual attitudes toward eating.The relationship between eating and emotions can be considered on two parallel levels: psychological and physiological.In the case of the psychological response, stress generates a variety of bodily responses relating to coping with stress.Objective therefore, the main objective of this study was to evaluate and compare the prevalence of emotional eating in groups of students in health-related and non-health-related fields in terms of their differential health behaviors-diet and physical activity levels.Material and methods the cross-sectional survey study included 300 individuals representing two groups of students distinguished by their fields of study-one group was in health-related fields (hrf) and the other was in non-health-related fields (nrf).The study used standardized questionnaires: the pss-10 and tfeq-13.Results the gender of the subjects was as follows: women, 60.0% (174 subjects) (hrf: 47.1%, n= 82; nrf: 52.9%, n = 92); men, 40.0% (116 subjects) (hrf: 53.4%, n = 62; nrf: 46.6%, n = 54).The age of the subjects was 26 years (±2 years).Based on the results of the tfeq-13, among 120 subjects (41.4%) there were behaviors consistent with limiting food intake (hrf: 72.4%; nrf: 11.0%), while 64 subjects (20.7%) were characterized by a lack of control over food intake (hrf: 13.8%, 20 subjects; nrf: 27.4%, 20 subjects).Emotional eating was characteristic of 106 students (37.9%), with the nrf group dominating (61.6%, n = 90).It was observed that a high pss-10 score is mainly characteristic of individuals who exhibit ee.Conclusions the results obtained in the study indicate that lifestyle can have a real impact on the development of emotional eating problems.Individuals who are characterized by elevated bmi values, unhealthy diets, low rates of physical activity, who underestimate meal size in terms of weight and calories, and have high-stress feelings are more likely to develop emotional eating.These results also indicate that further research in this area should be undertaken to indicate whether the relationships shown can be generalized.

Journal: Nutrients (2022)
Publication types: Journal Article
Biometry and Intraocular Lens Power Calculation by Combined Scheimpflug-Placido Disc versus Optical Interferometry Devices.

To compare the results of the current gold standard, laser interferometry, and keratometry by the iol-master, with a newly developed galilei g6 using raytracing software okulix for intraocular lens (iol) power calculations.Methods for comparison of the iol-power calculation of both devices, we analyzed the difference between the actual one-month postoperative subjective refraction and the theoretically calculated target refraction before cataract surgery.The iol was selected according to the iol master recommendation aiming for emmetropia after surgery.we analyzed the differences of the measurements of the basic biometric data in 205 healthy eyes by each device.Results our study included 205 healthy, unoperated eyes from 117 patients (61 women, 56 men) aged 20 to 75 years.Twenty-two eyes of cataract patients were also included in this retrospective study design.The mean difference between the prediction of the postoperative refraction and the refraction actually achieved was 0.03 d for the iol master and -0.23 d for the galilei g6.The difference was not statistically significant (p= 0.059).The difference between the iol power calculation of the iol master and the calculation of the g6 was not statistically significant (p= 0.064).The difference between the predicted refraction of the g6 and the refraction achieved after one month was also not statistically significant (p= 0.12) and neither was the difference between the predicted refraction of the iol master and the achieved refraction (p= 0.39).The mean axial length was calculated as 24.21±0.80 mm using the iol master and 24.27±0.82 mm using the galilei g6 device.The mean value regarding anterior chamber depth (acd) of the iol master was 3.46±0.23 mm and for the galilei was g6 3.51±0.25 mm.When comparing the white to white (wtw) values of the iol master, it showed mean values of 12.32±0.31 and galilei showed mean values of g6 12.21±0.28.All of these differences (between galileo and iol master measurements) were statistically significant (p<0.001).Conclusion both the laser interferometry/keratometry performed by the iol master and the interferometry/raytracing biometry strategy performed by the galilei g6 demonstrated equal results when executing the iol power calculation before cataract surgery in eyes with no prior ocular surgery.

Journal: Journal of ophthalmic & vision research (2022)
Publication types: Journal Article
Cloning, expression, purification and bioactivity evaluation of a thrombin-like enzyme from Deinagkistrodon acutus venom gland library.

S to identify a new member of serine proteases from deinagkistrodon acutus via phage display technique and appraise its biocatalytic activities.Results a novel thrombin-like enzyme gene was cloned by screening the phage display library of d.Acutus venom gland.The gene has a 783 bp orf encoding 260 amino acids.A recombinant enzyme expression vector was constructed and the fused protein was expressed in escherichia coli.The protein was purified showing a single band of approx.49.4 k da after sds-page.The recombinant enzyme was capable of congealing normal human plasma in vitro with the minimum coagulant dose of 6 μg in 57 s.It exhibited fibrinogenolytic activity by hydrolyzing the aα-chain of human fibrinogen.It was most active at p h 7.5-8.0 and 35-40 °c with the highest clotting activity of 120 nih units/mg.It was completely inhibited by pmsf but not by edta.Multiple sequence alignments demonstrate that this protein shares high identity with other thrombin-like enzymes from snake venoms.Conclusions a novel thrombin-like protein from d.Acutus venom was identified, expressed and biologically characterized in vitro.Its fibrinogenolytic properties make the enzyme applicable for biochemical research and drug development on thrombolytic therapy.

Journal: Biotechnology letters (2018)
Publication types: Journal Article
Surgical Treatment of IV Ventricle Calcifying Pseudoneoplasm of the Neuraxis (CAPNON) Operative Nuances.

Calcifying pseudoneoplasm of the neuroaxis (capnon) is a rare, slow growing, and generally benign fibro osseous mass that can emerge throughout the entire central nervous system (cns).When diagnosed, prompt surgical treatment can determine a good neurological outcome and possibly curative resolution.The objective of the present work is to present a step by step technical report with its video.We present a 37 year old female presented with occipital headache and cervical pain associated with dysphagia, nausea, and gait disturbances.Computed tomography (ct) scan showed a focal calcified lesion on the floor of the iv ventricle projecting toward the vermis with associated supratentorial hydrocephalus and transependymal edema.The telovelar approach was chosen for the procedure.The outcome was favorable, with no complications.Postoperative ct was performed, which revealed no residual lesion.A step by step report of a iv ventricle capnon that manifested with hydrocephalus is described.

Journal: Neurology India (2022)
Publication types: Case Reports;Journal Article
Polymeric Micro/Nanocarriers and Motors for Cargo Transport and Phototriggered Delivery.

Smart polymer-based micro/nanoassemblies have emerged as a promising alternative for transporting and delivering a myriad of cargo.Cargo encapsulation into (or linked to) polymeric micro/nanocarrier (pc) strategies may help to conserve cargo activity and functionality when interacting with its surroundings in its journey to the target.Pcs for cargo phototriggering allow for excellent spatiotemporal control via irradiation as an external stimulus, thus regulating the delivery kinetics of cargo and potentially increasing its therapeutic effect.Micromotors based on pcs offer an accelerated cargo-medium interaction for biomedical, environmental, and many other applications.This review collects the recent achievements in pc development based on nanomicelles, nanospheres, and nanopolymersomes, among others, with enhanced properties to increase cargo protection and cargo release efficiency triggered by ultraviolet (uv) and near-infrared (nir) irradiation, including light-stimulated polymeric micromotors for propulsion, cargo transport, biosensing, and photo-thermal therapy.We emphasize the challenges of positioning pcs as drug delivery systems, as well as the outstanding opportunities of light-stimulated polymeric micromotors for practical applications.

Journal: Polymers (2021)
Publication types: Journal Article;Review
Effect of Organic Farming and Agricultural Abandonment on Beneficial Arthropod Communities Associated with Olive Groves in Western Spain: Implications forBactrocera oleaeManagement.

Agricultural abandonment and intensification are among the main land-use changes in europe.Along with these processes, different proposals have been developed to counteract the negative effects derived from agricultural intensification, including organic management.In this context, we aimed to determine how organic management and farmland abandonment affect bactrocera oleaeand its main groups of natural enemies: hymenopteran parasitoids, spiders, ants, carabids, and staphylinids.Between may and october 2018, four samplings were carried out in nine olive groves (three under organic management, three under traditional management, and three abandoned) in a rural area on the border between spain and portugal (salamanca, western spain).Our results suggested differences between the natural enemy community composition of abandoned and organic groves, with slightly higher levels of richness and abundance in abandoned groves.We found no differences between organic and traditional groves.The managed olive groves sustained a different natural enemy community but were similarly rich and diverse compared with the more complex abandoned groves, with the latter not acting as a reservoir of b.Oleaein our study area.Both systems may provide complementary habitats; however, further abandonment could cause a reduction in heterogeneity at the landscape scale and, consequently, a biodiversity loss.

Journal: Insects (2022)
Publication types: Journal Article
No one asked us: Understanding the lived experiences of midwives providing care in the north west suburbs of Melbourne during the COVID-19 pandemic: An interpretive phenomenology.

Problem within the victorian healthcare system, a rapid response to the covid-19 pandemic has necessitated frequent and ongoing changes to midwifery practice.Background midwives are a vital workforce at risk of burnout, attrition, and trauma.Emotional consequences of the pandemic for midwives remain largely unknown.Aim to understand the lived experiences of midwives providing care in the north west suburbs of melbourne, victoria during the pandemic.Methods purposive and snowball sampling facilitated the recruitment of eight midwives in the north west suburbs of melbourne, victoria.Semi-structured interviews were audio recorded and transcribed, occurring via telephone or video between september and october 2020.Interpretive phenomenology was the methodology used, informed by the writings of heidegger and gadamer.Findings insights gleaned from the data embody a range of understandings.The unknown cost of change and adaptation; waves of the virus; balancing risk; telehealth; personal protective equipment; stripping away support; the privilege of abiding by the restrictions; separation, distress, uncertainty; and, professional strength.Discussion experiences of midwives during the pandemic are characterised by sensations of voicelessness and professional invisibility.Distinctive differences in personal wellbeing and professional satisfaction exist between midwives working with and without continuity of care.Conclusion this paper voices the lived experiences of victorian midwives, in the midst of an extended lockdown, during the covid-19 pandemic.Knowledge obtained from this research provides important understandings for leaders, policymakers, and healthcare systems, in planning a long-term response to the pandemic that supports the wellbeing and longevity of a vital workforce.

Journal: Women and birth : journal of the Australian College of Midwives (2022)
Publication types: Journal Article
Water quality of springs and lakes in the Kumaon Lesser Himalayan Region of Uttarakhand, India.

The scarcity of drinking water has become a bitter reality in many countries.The gap between demand and supply of water has been increasing exponentially year by year.Deforestation, vigorous use of groundwater for agricultural practices, and pollution of our present water resources such as rivers, lakes, and wells are triggering the freshwater scarcity problem.Ninety percent of people in uttarakhand depend on springs for their daily life activities.In such a case, the quality and quantity of spring water should be a prime topic to be focussed on.In the kumaon region of uttarakhand, spring water quality is good but there is an issue with its availability, especially in summer.This review paper details the studies that have been conducted on nutrient status, hardness, heavy metals, and the presence of microbiological diversity in spring water.It also uncovers information on some critical springs, geological settings of their aquifers, and the steps that have been adopted to rejuvenate the spring.Some other measures have been carried out by the government and local communities for springs' revival and their improvement in discharge rate, including the construction of percolation pits, contour trenches, check dams, and improvement of water resources.It has been observed among the analyzed sample that the kumaon region is dominated by arsenic, cadmium, chromium, and lead, whereas aluminum, barium, cobalt, and manganese are more in the garhwal region.Apart from springs, this review paper also reveals the physicochemical characteristics of the spring-fed rivers and lakes of the kumaon region.

Journal: Journal of water and health (2022)
Publication types: Journal Article;Review
Combinations of cypermethrin and dimethoate alter behavior, hematology and histology of African Catfish, Clarias gariepinus.

Cypermethrin and dimethoate are pesticides frequently used in agriculture to eliminate pests.Contemporaneity of these and other pesticides in commercial preparations and several aquatic ecosystems is well known, though poorly studied.This study aims to evaluate the effect of sublethal concentrations of combinations of cypermethrin and dimethoate on juvenile catfish, clarias gariepinus, given that the pesticides concomitantly occur in the floodplains were the fish breed.Behavioral, hematological and histopathological changes in juvenile fish exposed to sublethal concentrations were monitored for 96 hours.Pesticide exposed fish exhibited abnormal behaviors such as erratic swimming, frequent air gulping, sudden jerk movement and rapid opercula movement and these were more pronounced in higher concentrations.Significant reductions in erythrocytes (0.83-20.94%), hemoglobin (4.12-29.23%) and pvc (7.14-28.57%) and increase in leucocytes (4.84-9.32%) were observed (p<0.05).Mean corpuscular hemoglobin concentration (mchc), mean corpuscular hemoglobin (mch) and mean cell volume (mcv) reduced significantly in the exposed groups compared to the control.Infiltration of inflammatory cells, distortion of cell architecture, hemorrhage and necrosis were the observed histopathological damages in the heart, brain, gill, liver, kidney and fin of exposed fish.These pathological damages were more severe than previously reported for either chemical.Therefore, the use of these chemicals in agriculture should be regulated, especially near fish breeding sites.

Journal: Environmental analysis, health and toxicology (2022)
Publication types: Journal Article
The assesment of retina and optic disc vascular structures in people who received CoronaVac vaccine.

Introduction severe acute respiratory syndrome coronavirus 2 (sars-co v-2) is the virus that is responsible for the current coronavirus disease pandemic and the vaccines currently developed are administered to prevent this infection.Corona vac is a vaccine produced by the inactivated virus method.Ocular side effects such as anterior uveitis, optic neuritis, vision loss, episcleritis, allergic reaction and paracentral acute middle maculopathy have been reported after receiving corona vac vaccine.We assume that with this study, we can identify potential changes in posterior segment structures and posterior segment vascular density of people who received corona vac vaccine with optical coherence tomography angiography (octa) device.Material method forty healthcare professionals who applied to the health sciences university antalya training and research hospital ophthalmology clinic for routine eye control were included in the study.The subjects who do not have any systemic condition and would be administered corona vac vaccine were chosen to assess.Octa images of the patients before and within 1 week after vaccination were captured, then retinal and optic disc vascular values, foveal avascular zone (faz), choriocapillary blood flow (cbf), subfoveal choroidal thickness (sct) and retinal thickness were analyzed and compared.Results two of the 40 patients had burning and stinging in the eye (5%), two of the 40 patients had redness (5%) and itching (5%) in the eye.36 patients did not have any ocular symptoms.no statistically significant difference was found in the retinal and optic disc vascular density values, faz, cbf, sct and retinal thickness values ​​of the patients before and after vaccination.Conclusion this is among the first studies in the literature to evaluate the changes in retinal and optic disc vascular values ​​in people who received corona vac vaccine.In this study, we observed that corona vac vaccine did not effect retinal and optic disc vascular density significantly.

Journal: Photodiagnosis and photodynamic therapy (2022)
Publication types: Journal Article
Differential effects of excess high-fructose corn syrup on the DNA methylation of hippocampal neurotrophic factor in childhood and adolescence.

Consumption of fructose-containing beverages such as high-fructose corn syrup (hfcs) is increasing, raising concerns about the negative effects of excessive fructose intake.A recent report indicated that excess hfcs intake impairs hippocampal function.In this study, we focused on neurotrophic factors (nfs) in the hippocampus from the viewpoint of epigenetics to clarify the adverse effects of fructose.We analyzed the effects of hfcs intake on hippocampal function in three age categories: childhood and adolescence (postnatal day (pd) 21-60), young adulthood (pd60-100), and late adulthood (pd100-140).For the experiments, male sprague-dawley rats were divided into three age categories, the control group was received distilled water and the hfcs group was received 20% hfcs solution for 40 days in each period.We analyzed m rna and protein levels for q pcr and western blotting, respectively, of a hippocampal nf, brain-derived neurotrophic factor (bdnf).Hfcs consumption reduced hippocampal bdnf m rna and protein expressions in childhood and adolescence.Moreover, pyrosequencing assays revealed increased dna methylation at the bdnf promoter in childhood and adolescence.This bdnf levels reduction may be due to hypermethylation of the promoter regions.It should be noted that this phenomenon was observed only in childhood and adolescence fructose consumption.Our results indicate that the sensitivity of the hippocampus to fructose may vary with age.This study provides insight into the adverse effects of excessive hfcs consumption on the hippocampus in children.

Journal: PloS one (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't