syedzayyan/paper_mill_benchmark huggingface dataset:
Neural evidence for non-orofacial triggers in mild misophonia.

Misophonia, an extreme aversion to certain environmental sounds, is a highly prevalent yet understudied condition plaguing roughly 20% of the general population.Although neuroimaging research on misophonia is scant, recent work showing higher resting-state functional connectivity (rs-f mri) between auditory cortex and orofacial motor cortex in misophonia vs.Controls has led researchers to speculate that misophonia is caused by orofacial mirror neurons.Since orofacial motor cortex was defined using rs-f mri, we attempted to theoretically replicate these findings using orofacial cortex defined by task-based f mri instead.Further, given our recent work showing that a wide variety of sounds can be triggering (i.e., not just oral/nasal sounds), we investigated whether there is any neural evidence for misophonic aversion to non-orofacial stimuli.Sampling 19 adults with varying misophonia from the community, we collected resting state data and an f mri task involving phoneme articulation and finger-tapping.We first defined "orofacial" cortex in each participant using rs-f mri as done previously, producing what we call resting-state regions of interest (rs rois).Additionally, we functionally defined regions (f rois) representing "orofacial" or "finger" cortex using phoneme or finger-tapping activation from the f mri task, respectively.To investigate the motor specificity of connectivity differences, we subdivided the rs rois and f rois into separate sensorimotor areas based on their overlap with two common atlases.We then calculated rs-f mri between each rs roi/f roi anda priorinon-sensorimotor rois.We found increased connectivity in mild misophonia between rs rois and both auditory cortex and insula, theoretically replicating previous results, with differences extending across multiple sensorimotor regions.However, the orofacial task-based f rois did not show this pattern, suggesting the "orofacial" cortex described previously was not capturing true orofacial cortex; in fact, using task-based f mri evidence, we find no selectivity to orofacial action in these previously described "orofacial" regions.Instead, we observed higher connectivity between finger f rois and insula in mild misophonia, demonstrating neural evidence for non-orofacial triggers.These results provide support for a neural representation of misophonia beyond merely an orofacial/motor origin, leading to important implications for the conceptualization and treatment of misophonia.

Journal: Frontiers in neuroscience (2022)
Publication types: Journal Article
A compact NaI(Tl) with avalanche photodiode gamma spectrometer for in situ radioactivity measurements in marine environment.

In situ radioactivity measurements in a deep ocean environment are essential for marine environmental pollution monitoring and seabed geological exploration.In the past, the most widely used gamma spectrometers were based on towed instrumentation, which could only be operated underwater at a depth of less than 1500 m.In this study, a compact gamma spectrometer with small-size, light weight, and low power consumption was designed for working in a marine in situ environment.This spectrometer, with two essential parts: detector and electronics, was designed to work on different underwater platforms in the real-time control mode or autonomous operation mode.Multiple small volume avalanche photodiodes were coupled with na i(tl), which can significantly reduce the spectrometer volume compared with the option of the photomultiplier tube.Integrated readout electronics were employed to digitize all detector signals for miniaturization and low power consumption.The field programmable gate array (fpga) was used to obtain the energy spectrum in real-time and an online multi-channel summation with temperature calibration algorithm was employed to improve detection efficiency.Relevant tests were also conducted in the laboratory to evaluate critical techniques and system performance.Results show that the energy resolution (full width at half maximum over the peak position) was ∼7.5% at 662 ke v, verifying the online multi-channel summation with temperature calibration based on the fpga.Moreover, the compact prototype spectrometer worked well in the power-on hydraulic test.

Journal: The Review of scientific instruments (2021)
Publication types: Journal Article
Enhancing the Sensitivity of DNA and Aptamer Probes in the Dextran/PEG Aqueous Two-Phase System.

Increasing the local concentration of dna-based probes is a convenient way to improve the sensitivity of biosensors.Instead of using organic solvents or ionic liquids that phase-separate with water based on hydrophobic interactions, we herein studied a classic aqueous two-phase system (atps) comprising polyethylene glycol (peg) and dextran.Polymers of higher molecular weights and higher concentrations favored phase separation.Dna oligonucleotides are selectively enriched in the dextran-rich phase unless the p h was increased to 12.A higher volume ratio of peg-to-dextran and a higher concentration of peg also enrich more dna probes in the dextran-rich phase.The partition efficiency of the t15dna was enriched around seven times in the dextran phase when the volume ratio of dextran and peg reached 1:10.The detection of limit improved by 3.6-fold in a molecular beacon-based dna detection system with the atps.The atps also increased the sensitivity for the detection of hg2+and adenosine triphosphate, although these target molecules alone distributed equally in the two phases.This work demonstrates a simple method using water soluble polymers to improve biosensors.

Journal: Analytical chemistry (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Evaluation of hepatoprotective effect of Nebivolol and sodium copper Chlorophyllin on CCL4-induced hepatotoxicity in mice.

In this study, the protective effect of sodium copper chlorophyllin and nebivolol was evaluated in a mice model of ccl4 induced hepatotoxicity.Silymarin was used as a traditional hepatoprotective drug.Materials and methods thirty (30) mice were used as they were divided into five groups: the first group was the control group which received distilled water + olive oil, the second group which received 1.5 ml/kg of ccl4 diluted in olive oil three times a week, the third group which received ccl4 + silymarin 50 mg/kg/day, the fourth group which received ccl4 + nebivolol 4 mg/kg/day, and the fifth group which received 1.5 ml/kg of ccl4+ cu-chlorophyllin 50 mg/kg/day.The drugs were given by intraperitoneal route for 5 weeks.The detection, quantification of ccl4 induced hepatotoxicity and possible protective effect of either silymarin, nebivolol, or sodium copper chlorophyllin were assessed using biochemical analysis of alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp), total protein, lipid profile, an assay of oxidants and antioxidants, assay of interleukin 6 (il6) and tumor necrosis factor-alpha (tnf-α), and histopathological examination.Results the administration of carbon tetrachloride (ccl4) produced pronounced liver impairment.It significantly increased alt, ast, alp, malondialdehyde, and serum nitric oxide levels compared to normal control group besides a decrease in total protein, serum catalase, tissue sod, and gsh levels.Il-6 and tnf-α levels were significantly higher while total cholesterol was significantly lower in mice receiving ccl4 compared to the normal control group.Ccl4 induced severe hyperemia and congestion inside the portal area with leukocytic infiltration, hepatic degeneration, and bridge fibrosis.Conclusions co-administration of either silymarin, nebivolol, or sodium copper chlorophyllin with ccl4 was able to ameliorate up to almost contradict ccl4 induced hepatic injury through their anti-inflammatory and antioxidant activities.

Journal: European review for medical and pharmacological sciences (2022)
Publication types: Journal Article
Effect of Rifampin-Mediated OATP1B1 and OATP1B3 Transporter Inhibition on the Pharmacokinetics of the P2Y12 Receptor Antagonist Selatogrel.

In vitro studies have indicated that the p2y12 receptor antagonist selatogrel is a substrate of organic anion-transporting-polypeptide (oatp)1b1 and oatp1b3 that are known to mediate hepatic uptake.Selatogrel is primarily eliminated via the biliary route.Therefore, the study aim was to investigate the effect of rifampin-mediated oatp1b1 and oatp1b3 inhibition on the pharmacokinetics (pk) of selatogrel.This was a randomized, double-blind, placebo-controlled, two-period, crossover study in 14 healthy subjects.In each period, a single subcutaneous dose of 4 mg selatogrel was administered, either immediately after a single intravenous 30 minutes infusion of 600 mg rifampin or after placebo.Plasma samples were collected for 36 hours and analyzed using a validated liquid chromatography-tandem mass spectrometry method.Pk parameters of selatogrel were calculated using noncompartmental analysis.The effect of rifampin was explored based on geometric mean peak plasma concentration (cmax) and area under the concentration curve from zero to infinity (auc0-∞) ratios and for time of maximum plasma concentration (tmax) by wilcoxon signed rank test.In addition, the safety and tolerability of the study treatments were evaluated.The geometric mean ratios of cmaxand auc0-∞were 1.19 (90% confidence interval (ci) 1.11-1.28) and 1.43 (90% ci 1.36-1.51), respectively, indicating a minor selatogrel exposure increase when administered after an infusion of rifampin compared with placebo.Rifampin administration did not affect terminal half-life (t1⁄2) or tmaxof selatogrel.All study treatments were safe and well-tolerated.A single dose of 600 mg rifampin, a potent oatp1b1/1b3 inhibitor, did not impact the pk of selatogrel to a clinically relevant extent suggesting that oatp1b1 and oatp1b3 transporters do not play a major role in the elimination of selatogrel.

Journal: Clinical and translational science (2020)
Publication types: Clinical Trial, Phase I;Journal Article;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
Clinician Perceptions About a Decision Support System to Identify and Manage Opioid Use Disorder.

Addressing the opioid epidemic would benefit from primary care clinicians identifying and managing opioid use disorder (oud) during routine clinical encounters, but current rates are low.Clinical decision support (cds) systems are a promising way to facilitate such interactions, but will clinicians use them?Methods we iteratively conducted semi-structured interviews with 8 purposively sampled primary care clinicians participating in a pilot oud-cds study to identify attitudes toward discussing oud and preferences for support in doing so.Five of them had used a pilot version of the cds for 6 months, while the others were in comparison clinics.Interviews were recorded, transcribed, and analyzed by a multi-disciplinary group of experienced researchers, using an editing organizing style where the analysts independently highlighted relevant text and then discussed to reach a consensus on themes.Results we identified five themes: 1.Primary care is the right place to address oud.2.Both clinician-patient and clinician-clinician relationships affect how and whether clinicians address oud in a particular patient encounter.3.The main challenges are limited time and competing priorities for these complex patients.4.Although a cds for oud could be very helpful, it must meet different needs for different clinicians and clinical situations and be simple to use.5.For optimal benefit, the cds needs to be complemented by supportive organizational policies and systems as well as local clinician encouragement.Conclusions with the right design and a supportive organization, these primary care clinicians believe a cds could help them regularly identify and address oud among their patients as long as it incorporates their concerns about relationships, competing priorities, patient complexity, and user simplicity.

Journal: Journal of the American Board of Family Medicine : JABFM (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural
JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer.

Endocrine resistance (en r) in advanced prostate cancer is fatal.En r can be mediated by androgen receptor (ar) splice variants, with ar splice variant 7 (ar-v7) arguably the most clinically important variant.In this study, we determined proteins key to generating ar-v7, validated our findings using clinical samples, and studied splicing regulatory mechanisms in prostate cancer models.Triangulation studies identified jmjd6 as a key regulator of ar-v7, as evidenced by its upregulation within vitro en r, its downregulation alongside ar-v7 by bromodomain inhibition, and its identification as a top hit of a targeted si rna screen of spliceosome-related genes.Jmjd6 protein levels increased (p< 0.001) with castration resistance and were associated with higher ar-v7 levels and shorter survival (p= 0.048).Jmjd6 knockdown reduced prostate cancer cell growth, ar-v7 levels, and recruitment of u2af65 to ar pre-m rna.Mutagenesis studies suggested that jmjd6 activity is key to the generation of ar-v7, with the catalytic machinery residing within a druggable pocket.Taken together, these data highlight the relationship between jmjd6 and ar-v7 in advanced prostate cancer and support further evaluation of jmjd6 as a therapeutic target in this disease.Significance: this study identifies jmjd6 as being critical for the generation of ar-v7 in prostate cancer, where it may serve as a tractable target for therapeutic intervention.

Journal: Cancer research (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
Altered spontaneous brain activity in Down syndrome and its relation with cognitive outcome.

Although down syndrome (ds) is the most common genetic cause of neurodevelopmental delay, few neuroimaging studies have explored this population.This investigation aimed to study whole-brain resting-state spontaneous brain activity using fractional amplitude of low-frequency fluctuation (f alff) and regional homogeneity (re ho) strategies to find differences in spontaneous brain activity among young people with ds and controls and to correlate these results with cognitive outcomes.The sample comprised 18 persons with ds (age mean = 28.67, standard deviation = 4.18) and 18 controls (age mean = 28.56, standard deviation = 4.26).F alff and re ho analyses were performed, and the results were correlated with other cognitive variables also collected (kbit-2 and verbal fluency test).Increased activity was found in ds using f alff in areas involving the frontal and temporal lobes and left cerebellum anterior lobe.Decreased activity in ds was found in the left parietal and occipital lobe, the left limbic lobe and the left cerebellum posterior lobe.Re ho analysis showed increased activity in certain ds areas of the left frontal lobe and left rectus, as well as the inferior temporal lobe.The areas with decreased activity in the ds participants were regions of the frontal lobe and the right limbic lobe.Altered f alff and re ho were found in the ds population, and this alteration could predict the cognitive abilities of the participants.To our knowledge, this is the first study to explore regional spontaneous brain activity in a population with ds.Moreover, this study suggests the possibility of using f alff and re ho as biomarkers of cognitive function, which is highly important given the difficulties in cognitively evaluating this population to assess dementia.More research is needed, however, to demonstrate its utility.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Quantum Control of Graphene Plasmon Excitation and Propagation at Heaviside Potential Steps.

Quantum mechanical effects of single particles can affect the collective plasmon behaviors substantially.In this work, the quantum control of plasmon excitation and propagation in graphene is demonstrated by adopting the variable quantum transmission of carriers at heaviside potential steps as a tuning knob.First, the plasmon reflection is revealed to be tunable within a broad range by varying the ratio γ between the carrier energy and potential height, which originates from the quantum mechanical effect of carrier propagation at potential steps.Moreover, the plasmon excitation by free-space photos can be regulated from fully suppressed to fully launched in graphene potential wells also through adjusting γ, which defines the degrees of the carrier confinement in the potential wells.These discovered quantum plasmon effects offer a unified quantum-mechanical solution toward ultimate control of both plasmon launching and propagating, which are indispensable processes in building plasmon circuitry.

Journal: Nano letters (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Ethanol ablation for the treatment of benign thyroid nodules.

Ethanol ablation (ea) is a non-surgical option for the treatment of benign cystic thyroid nodules.This study summarizes our preliminary experience with the efficacy and safety of ea.Methods a retrospective analysis was performed of patients undergoing ea for symptomatic, benign, cystic and predominantly cystic (≥75%) thyroid nodules.Baseline nodule volume, cosmetic scores, and symptom scores were assessed, as well as volume reduction ratio (vrr), cosmetic and symptom scores at post-procedure months 1, 3, 6, and 12.Results 31 patients underwent an uncomplicated ea for a single cyst with an average volume of 21.3 cc (range: 1.7-101.4 cc).Follow-up was limited by the covid-19 pandemic.Mean nodule vrrs were 66 ± 20% (1 m, n = 17), 87 ± 15% (3 m, n = 9), 72 ± 20% (6 m, n = 7), and 78% (12 m, n = 3).Mean symptom and cosmetic scores decreased concurrently post-procedure.Conclusion ea is a safe, effective option for benign cystic and predominantly cystic thyroid nodules.

Journal: American journal of surgery (2022)
Publication types: Journal Article
Usefulness of serum glucose and potassium ratio as a predictor for 30-day death among patients with severe traumatic brain injury.

Serum glucose and potassium ratio (gpr) was recently found to be related to outcome of aneurysmal subarachnoid hemorrhage.This retrospectively study was to investigate the association of serum gpr with mortality in severe traumatic brain injury (s tbi).Methods clinical data were retrospectively reviewed of isolated s tbi patients admitted within 12 h after trauma between january 2014 and january 2019.We analyzed relationships between admission serum gpr and post-traumatic 30-day mortality in addition to admission glasgow coma scale (gcs) scores.Discriminative ability was evaluated using area under receiver operating characteristic curve (auc).Results a total of 146 patients, of whom 37 (25.3%) died within 30 days following trauma, were included.Admission serum gpr emerged as an independent predictor for 30-day mortality (odds ratio, 5.256; 95% confidence interval (ci), 1.111-14.856) and overall survival (hazard ratio, 4.822; 95% ci, 1.157-12.870), with an auc of 0.777 (95% ci, 0.693-0.835), which was equivalent to that of gcs scores (auc, 0.831; 95% ci, 0.760-0.888; p = 0.179).There was a significant correlation between admission serum gpr and gcs scores (r2= 0.293).Conclusions serum gpr in cases of s tbi is substantially associated with trauma severity and 30-day mortality.Therefore, the potential value of serum gpr for predicting short-term mortality of s tbi patients is favorable.

Journal: Clinica chimica acta; international journal of clinical chemistry (2020)
Publication types: Journal Article
Hematopoetic stem cell transplantation in children.

Bone marrow transplantation is called hematopoetic stem cell transplantation (hsct), since peripheral blood and umbilical cord blood can also be used as sources of stem cell currently.In children, bone marrow transplantation is used as a definite treatment method in many diseases including hemoglobinopaties, immune deficiencies, bone marrow failure and congenital metabolic diseases in addition to hematological malignancies.In addition to the underlying disease, the most important factors which have an impact on prognosis include infections which develop during the process of transplantation and graft-versus-host disease.In this article, it was aimed to give brief information on stem cell sources, preparation therapies, hsct indications and post-transplantation complications in children.

Journal: Turk pediatri arsivi (2014)
Publication types: Journal Article;Review
Comparison between cryoballoon and hot balloon ablation in patients with paroxysmal atrial fibrillation.

Pulmonary vein (pv) isolation using balloon ablation was developed as a technique for patients with paroxysmal atrial fibrillation (paf).While most studies examined cryoballoon ablation (cba), there have also been many reports on hot balloon ablation (hba).We aimed to evaluate the clinical characteristics and outcomes between hba and cba.Methods in a total of 103 consecutive patients with paf who underwent catheter ablation, 60 propensity score-matched (30 cba and 30 hba) patients were enrolled.The procedural differences and clinical outcomes between the two groups were analyzed.Results the requirement for additional touch-up ablation was more frequent in the left superior pulmonary vein (lsp) in the hba group than in the cba group.Pre-procedural computed tomography (ct) images showed that a thicker left pulmonary vein ridge and larger cross-sectional area of the lspv were significantly associated with residual pv potentials after hba.However, post-procedural ct images showed that pv stenosis (> 25%) was higher in the hba group (33%) than in the cba group (0%).Pv stenosis after hba was observed most frequently in the right superior pv (50%).The atrial fibrillation/atrial tachycardia-free survival rate during follow-up (365 ± 102 days) was similar between the two groups (cba vs.Hba, 83% vs.90%).Conclusions although both balloon modalities can relieve atrial arrhythmia after the procedure, careful attention is required during hba procedures, especially for the right superior pv, to avoid pv stenosis.

Journal: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing (2022)
Publication types: Journal Article
Effects of hypotension and hypertension on source memory and working memory.

S the effects of chronic low and high blood pressure on memory are unclear due to divergent results, originating in part due to participant misclassifications.The aim of this study was to compare source memory and working memory performance in individuals diagnosed with hypotension or hypertension with the performance of normotensive participants.Hypertensive and hypotensive individuals were receiving medical treatment.Method from a sample of 1656 participants, 219 were identified as hypertensive, and 37 were identified as hypotensive.Each of these two groups was compared with normotensive individuals matched by age, education and sex.Source memory performance and working memory performance were assessed through computerized tasks.Results source memory accuracy was poorer in hypotensive and hypertensive individuals than in normotensive individuals, and spatial working memory discrimination was inferior in hypertensive participants compared to normotensive individuals.Conclusion blood pressure impairment should be considered a major concern because it has been linked to severe cardiovascular and cerebrovascular diseases.Furthermore, here we show that it has negative effects on the two types of memory that are most essential for preserving a self-sufficient lifestyle.

Journal: Aging & mental health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't