syedzayyan/paper_mill_benchmark huggingface dataset:
Level and variation on quality of care in China: a cross-sectional study for the acute myocardial infarction patients in tertiary hospitals in Beijing.

Quality of care (qo c) attracts global concerns when unsafe and misuse of healthcare wastes resources and endangers people's health, especially in low- and middle-income countries.However, little is known about quality of care delivered in china.This study was intended to gauge the quality of care for acute myocardial infarction (ami) patients in beijing and identify the quality gaps across tertiary hospitals.Methods one thousand two hundred twenty eight patients, covered by employee essential health insurance scheme and diagnosed of ami, was sampled from 14 large comprehensive hospitals in beijing, china.Chart review study was conducted through the discharge data and medical records of inpatients to evaluate 6 quality outcomes of interest, including the use of aspirin, beta blocker, and statin at discharge; use of aspirin within 24 h at arrival; angiotensin-converting enzyme inhibitors (acei) or angiotensin receptor blocker (arb) for left ventricular systolic dysfunction (lvsd); percutaneous transluminal coronary intervention (pci) within 90 min at arrival.Results of the 1228 subjects, the mean age was 60.8 (11.8 sd) years and 83.0% were male.The overall medication prescribed was highly compliant with the clinical guidelines (97.0% [95% ci 96.8-97.2] for aspirin and 96.3% [95% ci 96.0-96.5] for statin), except for beta-blocker (83.6% [95% ci 83.0-84.1]) and acei/arb use (61.4% [95% ci 60.7-62.2]).More than half of eligible patients did not receive appropriate pci therapy (44.0% [95% ci 42.5-45.4]).Great variations across hospitals was observed in aspirin within 24 h and beta-blocker at discharge (p < 0.001), and the risk-adjusted results remained robust.Conclusion underuse of recommended treatment and significant variations of quality were found for ami patients across tertiary hospitals in beijing.It raised great concerns on poorer quality of care in other less-developed areas with less medical resources.Practical actions are needed in reducing quality gaps to ensure the delivery of quality care.

Journal: BMC health services research (2019)
Publication types: Evaluation Study;Journal Article
Kikuchi-Fujimoto disease following SARS-CoV-2 vaccination.

A previously healthy japanese woman in her 20s was admitted to our hospital with a 2-week history of fever (39.0°c) and a 1-week history of painful cervical lymphadenopathy.The day before fever onset, she had received her first pfizer-bio ntech sars-co v-2 vaccine in her left arm.She had previously been treated with empirical antibiotics with no improvement.Physical examination revealed painful lymphadenopathy in both posterior cervical regions.Ct showed symmetrical lymphadenopathies in the neck, supraclavicular, axillary and inguinal regions as well as hepatosplenomegaly.We suspected lymphoma and performed a lymph node biopsy in the right inguinal region, which revealed necrotising histiocytic lymphadenitis.The patient was, therefore, diagnosed with kikuchi-fujimoto disease (kfd).She improved after the corticosteroid therapy.This report highlights the importance of including kfd as a differential diagnosis of lymphadenopathy after sars-co v-2 vaccination.Additionally, lymph node biopsy is helpful for diagnosing kfd because it rules out other entities.

Journal: BMJ case reports (2022)
Publication types: Case Reports;Journal Article
Inflammatory Cloacogenic Polyp: A Rare Benign Colorectal Polyp.

Inflammatory cloacogenic polyps are a rare kind of benign polyp that is located in the anal transitional zone and rectum.We report the case of a 53-year-old male who underwent a diagnostic colonoscopy for a positive fecal immunochemical test.Two 7 mm polyps were found in the rectum with a pathological diagnosis of inflammatory cloacogenic polyp.The polyp was endoscopically resected.These polyps are associated with chronic inflammatory conditions such as crohn's disease and colorectal tumors.Because of malignant transformation potential, inflammatory cloacogenic polyps are endoscopically removed.

Journal: Cureus (2022)
Publication types: Case Reports;Journal Article
Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Accelerate Diabetic Wound Healing via Promoting M2 Macrophage Polarization, Angiogenesis, and Collagen Deposition.

Some scholars have suggested that the clinical application of exosomes derived from human umbilical cord mesenchymal stem cells (huc mscs-exo) might represent a novel strategy to improve diabetic wound healing.However, the mechanisms underlying the effects of huc mscs-exo on wound healing remain poorly understood.This study aimed to identify the mechanism of huc mscs-exo in treating diabetic wounds.Huc mscs-exo were isolated from human umbilical cord mesenchymal stem cells (huc mscs) and subcutaneously injected into full-thickness wounds in diabetic rats.Wound healing closure rates and histological analysis were performed.The levels of tumor necrosis factor-α (tnf-α), macrophage mannose receptor (mmr/cd206), platelet endothelial cell adhesion molecule-1 (pecam-1/cd31), and vascular endothelial growth factor (vegf) were detected by immunohistochemistry.The degree of collagen deposition was examined using masson's trichrome staining.Gross evaluation of wound healing was carried out from day 0 to 14 post-surgery, and the wound site was harvested for histology on days 3, 7, and 14 post-wounding.Huc mscs-exo transplantation increased diabetic wound healing.In vitro, huc mscs-exo promoted the proliferation of human umbilical vein endothelial cells (huvecs) and nih-3t3 cells.In vivo, huc mscs-exo reduced wound area and inflammatory infiltration and increased collagen fibers.In addition, wound tissues in the huc mscs-exo group had higher cd206, cd31, and vegf expressions and lower tnf-α levels than those in the control group on day 14.Our results demonstrated that huc mscs-exo facilitated diabetic wound repair by inducing anti-inflammatory macrophages and promoting angiogenesis and collagen deposition.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article
Controlled drug delivery and cell adhesion for bone tissue regeneration by Keplerate polyoxometalate (Mo132)/metronidazole/PMMA scaffolds.

The aim of this study is to fabricate a new scaffold appropriate for tissue regeneration with antimicrobial activity and ability of controlled drug delivery.In this regard, scaffold nanofibers were produced using poly (methyl methacrylate) (pmma), mo132as a keplerate polyoxometalate and metronidazole.The final scaffolds, obtained by electrospinning, represent the intrinsic features including exceptional doubling tensile strength, high hydrophilicity (126 ± 5.2° to 83.9 ± 3.2° for contact angle and 14.18 ± 0.62% to 35.62 ± 0.24% for water uptake), proper bioactivity and cell adhesion.Moreover, the addition of mo132and metronidazole enhances the biodegradation rate of resulted scaffolds compared to the pure pmma membrane.The controlled release of metronidazole over 14 days efficiently inhibits the colonization of anaerobic microorganisms.Overall, the results demonstrate high potential of mo132and metronidazole-loaded pmma scaffold for guided bone regeneration/guided tissue regeneration.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
"I Would Never Push a Vaccine on You": A Qualitative Study of Social Norms and Pressure in Vaccine Behavior in the U.S.

Previous researchers have established the influence of social norms on vaccine behavior.However, little work has been performed contextualizing individuals' experience with these social factors and how they operate to persuade individuals' acceptance or refusal of a vaccine.We aimed to determine the mechanisms of familial and societal pressure or expectations that contribute to covid-19 vaccine decision-making.We conducted four focus groups and eleven individual interviews (total n = 32) with participants from across the u.s.Of different vaccination statuses.We identified three emergent themes: (1) altruistic reasoning was particularly prevalent among initially hesitant late adopters-the desire to protect loved ones and others constituted a dominant motive, more powerful than protecting oneself.Vaccination was also reckoned as part of a joint effort to return to normal life; hence, it invoked a sense of responsibility or "obligation"; (2) expectation often became pressure; although most vaccinated participants stated that they respected others' choices, late adopters or unvaccinated participants perceived differently and felt rushed or "forced" into choosing, and many resented being "targeted" or "bullied"; (3) vaccination status became a new label, frequently dividing families, thus producing familial mandates, exclusions, or social stratifications.This caused sadness and feelings of isolation, along with the formation of a camaraderie among the excluded unvaccinated.A vaccine decision builds from the complexities of individuals' experiences and cultures.The vaccinated were not free of hesitancy nor were the unvaccinated all anti-vaxxers.Vigorous vaccine promotion successfully converted some undecided individuals but also fostered distrust of government; alarmingly, the push to receive the covid-19 vaccine further triggered doubts about established vaccines.Communication strategies need to be developed and implemented carefully so as not to ostracize the unvaccinated community and strengthen their resistance.

Journal: Vaccines (2022)
Publication types: Journal Article
Ultrasound-guided rhomboid intercostal block for myofascial pain syndrome: a prospective clinical study.

Myofascial pain syndrome (mps) is a common chronic pain syndrome that may affect quality of life, daily living activities, and psychological status.Ultrasound (us)-guided rhomboid intercostal block (rib) is a recently defined plane block and used for chronic pain such as postmastectomy syndrome and mps.Our aim was to evaluate the efficacy of us-guided rib for the management of pain, quality of life, physical disability, and patient satisfaction in mps.Methods in this prospective study, between february and march 2021, a total of 30 patients who applied with the diagnosis of mps, were included.The patients received us-guided rib.Pain intensity was evaluated using a numerical rating scale (nrs) at pretreatment, and just after the intervention, at day 1, and 1, 2, 4, and 6 weeks after the intervention.At pretreatment and 6 weeks after treatment, short form-36 health survey (sf-36) for health-related quality of life, neck disability index (ndi), and patient satisfaction were evaluated.Results there was a statistically significant decrease in average nrs immediately after treatment, at day 1 and week 1,2,4, and 6 compared to the pretreatment (p < 0.0001).The average sf-36 scores advanced at 6 weeks after treatment.There was a statistically significant reduction in mean ndi scores throughout the follow-up period (p < 0.001).Discussion our study demonstrated that rib had improved neck function, physical and mental quality of life, and patient satisfaction in mps.Therefore, we think us-guided rib could be an alternative treatment modality in patients suffering from mps.

Journal: Turkish journal of medical sciences (2022)
Publication types: Journal Article
The impact of COVID-19 on liver transplantation programs in Austria.

Coronavirus disease of 2019 (covid-19) has affected liver disease management.The impact of the covid-19 pandemic on the austrian orthotopic liver transplantation (olt) programs, however, has not been systematically investigated.Methods all patients listed for olt in austria during 2020-2021 were studied.Data on severe acute respiratory syndrome coronavirus 2 (sars-co v-2) testing, vaccinations, infections, mortality and the overall number of olts (vs.Pre-covid-19: 2015-2019) were analyzed.Results overall, 490 patients (median age: 58.0 years, 70.4% men, hepatocellular carcinoma: 27.3%) were listed for olt in austria in 2020-2021.Alcohol-related cirrhosis (35.3%), cholestatic (16.7%) and viral liver disease (13.9%) were the main etiologies.Of the patients 61.2% underwent olt and 8.8% died while on the waiting list.The number of olts performed during covid-19 (2020: n = 150; 2021: n = 150) remained unchanged compared to pre-covid-19 (median: n = 152).Among waiting list patients, 7.7% (n = 31/401) were diagnosed with covid-19 and 7 (22.6%) of these patients died.By the end of 2021, 45.1% (n = 176/390; 82.8% m rna vaccinations) and 28.8% (105/365) of patients received 2 and 3 sars-co v‐2 vaccinations, respectively.After two sars-co v‐2 vaccinations, antibodies more often remained undetectable in patients vaccinated post-olt (25.6% vs.6.5% in patients vaccinated pre-olt; p = 0.034).Patients with three vaccinations after olt had lower antibody titers than patients vaccinated pre-olt (post-olt: 513.5, iqr 44.4-2500.0 vs.Pre-olt: 2500.0, iqr 1462.0-2500.0 bau/m l; p = 0.020).Conclusion the number of olts in austria remained unchanged during covid-19.Sars-co v‐2 infections were rare but associated with high mortality in patients on the austrian olt waiting lists.Sars-co v‐2 vaccination rates at the end of 2021 were suboptimal, while serological response was better in patients vaccinated pre-olt vs.Post-olt.

Journal: Wiener klinische Wochenschrift (2022)
Publication types: Journal Article
Cannabidiol Improves Antioxidant Capacity and Reduces Inflammation in the Lungs of Rats with Monocrotaline-Induced Pulmonary Hypertension.

Cannabidiol (cbd) is a plant-derived compound with antioxidant and anti-inflammatory properties.Pulmonary hypertension (ph) is still an incurable disease.Cbd has been suggested to ameliorate monocrotaline (mct)-induced ph, including reduction in right ventricular systolic pressure (rvsp), a vasorelaxant effect on pulmonary arteries and a decrease in the white blood cell count.The aim of our study was to investigate the effect of chronic administration of cbd (10 mg/kg daily for 21 days) on the parameters of oxidative stress and inflammation in the lungs of rats with mct-induced ph.In mct-induced ph, we found a decrease in total antioxidant capacity (tac) and glutathione level (gsh), an increase in inflammatory parameters, e.g., tumor necrosis factor alpha (tnf-α), interleukin-1β (il-1β), nuclear factor kappa b (nf-κb), monocyte chemoattractant protein-1 (mcp-1), and cluster of differentiation 68 (cd68), and the overexpression of cannabinoid receptors type 1 and 2 (cb1-rs, cb2-rs).Administration of cbd increased tac and gsh concentrations, glutathione reductase (gsr) activity, and decreased cb1-rs expression and levels of inflammatory mediators such as tnf-α, il -1β, nf-κb, mcp-1 and cd68.In conclusion, cbd has antioxidant and anti-inflammatory effects in mct-induced ph.Cbd may act as an adjuvant therapy for ph, but further detailed preclinical and clinical studies are recommended to confirm our promising results.

Journal: Molecules (Basel, Switzerland) (2022)
Publication types: Journal Article
Exploring the inhibitory effects of liquiritigenin against tau fibrillation and related neurotoxicity as a model of preventive care in Alzheimer's disease.

Aggregation of tau protein into the form of insoluble amyloid fibrils is linked with alzheimer's disease.The identification of potential small molecules that can inhibit tau protein from undergoing aggregation has received a great deal of interest, recently.In the present study, the possible inhibitory effects of liquiritigenin as a member of chiral flavanone family on tau amyloid fibrils formation and their resulting neurotoxicity were assessed by different biophysical and cellular assays.The inhibitory effect of the liquiritigenin against tau amyloid formation was investigated using thioflavin t (th t) and 1-anilino-8-naphthalene sulfonate (ans) fluorescence spectroscopy, congo red (cr) binding assays, transmission electron microscopy (tem) analysis, and circular dichroism (cd) spectroscopy.Neurotoxicity assays were also performed against neuron-like cells (sh-sy5y) using 3-(4,5-dimethylthiazol)-2,5-diphenyltetrazolium bromide (mtt) reduction, reactive oxygen species (ros), catalase (cat) and caspase-3 activity measurements.We found that liquiritigenin served as an efficient inhibitor of tau amyloid fibrils formation through prevention of structural transition in tau structure, exposure of hydrophobic patches and their associated neurotoxicity mediated by decrease in the production of ros and caspase-3 activity and elevation of cat activity.These data may finally find applications in the development of promising inhibitors against amyloid fibril formation and treatment of alzheimer's disease.

Journal: International journal of biological macromolecules (2021)
Publication types: Journal Article
Acute Pancreatitis in Individuals with COVID-19: A Case Report and Critical Review of Literature.

Involvement of gastrointestinal tract has been reported in individuals diagnosed with covid-19.Herein, we report a case of 65-year-old woman with type 2 diabetes mellitus, hypertension, and end-stage renal disease undergoing hemodialysis who was initially diagnosed with covid-19 on a screening test.During the course of the disease, her respiratory symptoms remained mild; however, she developed acute pancreatitis leading to severe hypertension and hyperosmolar hyperglycemic state.During the hospitalization and treatment of acute pancreatitis, hyperglycemia, and hypertension, her condition improved and she was discharged in stable condition.

Journal: Case reports in medicine (2022)
Publication types: Case Reports;Journal Article
3D-Printed Multifunctional Polyetheretherketone Bone Scaffold for Multimodal Treatment of Osteosarcoma and Osteomyelitis.

In this work, we developed the first 3d-printed polyetheretherketone (peek)-based bone scaffold with multi-functions targeting challenging bone diseases such as osteosarcoma and osteomyelitis.A 3d-printed peek/graphene nanocomposite scaffold was deposited with a drug-laden (antibiotics and/or anti-cancer drugs) hydroxyapatite coating.The graphene nanosheets within the scaffold served as effective photothermal agents that endowed the scaffold with on-demand photothermal conversion function under near-infrared laser irradiation.The bioactive hydroxyapatite coating significantly boosted the stem cell proliferationin vitroand promoted new bone growthin vivo.The presence of antibiotics and anti-cancer drugs enabled eradication of drug-resistant bacteria and ablation of osteosarcoma cancer cells, the treatment efficacy of which can be further enhanced by on-demand laser-induced heating.The promising results demonstrate the strong potential of our multi-functional scaffold in applications such as bone defect repair and multimodal treatment of osteosarcoma and osteomyelitis.

Journal: ACS applied materials & interfaces (2021)
Publication types: Journal Article
Development and Validation of A Liquid Chromatography-Tandem Mass Spectrometry Method to Simultaneously Measure Tacrolimus and Everolimus Concentrations in Kidney Allograft Biopsies After Kidney Transplantation.

Therapeutic drug monitoring is necessary for immunosuppressive therapy with tacrolimus and everolimus after kidney transplantation.Several studies have suggested that the concentrations of immunosuppressive agents in allografts may better reflect clinical outcomes than whole blood concentrations.This study aimed to develop a method for the simultaneous quantification of tacrolimus and everolimus concentrations in clinical biopsy samples and investigate their correlation with histopathological findings in kidney transplant recipients.Methods fourteen biopsy samples were obtained from kidney transplant recipients at 3 months after transplantation.Kidney allograft concentrations (ctissue) of tacrolimus and everolimus were measured by liquid chromatography-tandem mass spectrometry, and the corresponding whole blood trough concentrations (c0) were obtained from clinical records.Results the developed method was validated over a concentration range of 0.02-2.0 ng/m l for tacrolimus and 0.04-4.0 ng/m l for everolimus in kidney tissue homogenate.The ctissue of tacrolimus and everolimus in kidney biopsies ranged from 21.0 to 86.7 pg/mg tissue and 33.5-105.0 pg/mg tissue, respectively.Dose-adjusted ctissue of tacrolimus and everolimus was significantly correlated with the dose-adjusted c0 (p < 0.0001 and p = 0.0479, respectively).No significant association was observed between the ctissue of tacrolimus and everolimus and the histopathologic outcomes at 3 months after transplantation.Conclusions this method could support further investigation of the clinical relevance of tacrolimus and everolimus allograft concentrations after kidney transplantation.

Journal: Therapeutic drug monitoring (2022)
Publication types: Journal Article
pH-Responsive Degradable Dextran-Quantum Dot Nanohybrids for Enhanced Gene Delivery.

It is of great significance to develop biocompatible and degradable gene carriers with stimuli-enhanced gene therapy and imaging function.In this work, low-cytotoxic polycation pgea (ethanolamine-functionalized poly(glycidyl methacrylate))-functionalized dextran-quantum dot (qd) nanohybrids (dq-pgea) were proposed as safe and efficient gene carriers via a facile and feasible method.The highly water-soluble dextran gives the carrier good stability, biocompatibility, and abundant modification sites, while qds allow fluorescence (fl) imaging.Taking advantage of the p h-responsive self-destruction characteristic introduced by schiff base linkages, dq-pgea nanohybrids could not only result in enhanced gene release but also contribute to the elimination of the carriers.Reduced (nondegradable) dq-pgea-r nanohybrids were also synthesized as counterparts to reveal the superiority of the responsive dq-pgea carriers.The effectiveness of the as-prepared gene delivery systems was verified adopting the antioncogene p53 in the mouse model of breast cancer.As expected, dq-pgea nanohybrids demonstrated a superior gene transfection performance and antitumor inhibition compared with their counterparts.Meanwhile, the gene delivery processes could be tracked in real time to visualize the therapeutic processes and realize fl imaging-guided gene therapy.The current multifunctional stimuli-responsive nanoplatforms with the self-destruction feature are intriguing candidates to achieve enhanced gene therapy for tumor treatment.

Journal: ACS applied materials & interfaces (2019)
Publication types: Journal Article