syedzayyan/paper_mill_benchmark huggingface dataset:
Impact of the COVID-19 Pandemic on the Psychosexual Functions of Healthcare Workers.

A novel infection, covid-19, emerged in china and soon became a global pandemic.Pandemic conditions have resulted in stress in the workplace and led to anxiety among healthcare workers (hcws), having negative impacts on different aspects of their lives, including their sexual function.Aim to evaluate the changes in the anxiety status of hcws during the covid-19 pandemic and the impact of anxiety on their sexual functions.Methods this is a longitudinal study based on an online survey conducted from april 2020 to february 2021 in hospitals designated as pandemic healthcare centers.An online survey link was sent to hcws that provided consent for participation in the study.The anxiety status of the participants was assessed using the state anxiety inventory, and sexual function was evaluated using the international index of erectile function-15 for men and female sexual function index for women.Outcomes scores obtained at the beginning of the pandemic were compared with those obtained at 6 months into the pandemic to determine the changes in the anxiety levels and sexual functions of the hcws.Results a total of 399 hcws participated in the survey, and the median age was 32 (20-60) years.Compared to the beginning of the pandemic, there was a significant increase in the state anxiety inventory score of the female and male hcws at the sixth month of the pandemic.Among the women, the mean total female sexual function index score was 23.55 ± 8.69 at the beginning of the pandemic and 21.42 ± 8.91 at the sixth month, and there was a significant decrease in all parameters except pain.Among the men, the international index of erectile function-15 total score was 62.75 ± 12.51 at the beginning of the pandemic and 55.1 ± 12.87 at the sixth month, indicating a significant decrease in all parameters.Clinical implications considering that the pandemic will continue for a long time, more psychological support should be provided, and interventions should be made to protect the mental health of hcws.Strengths & limitations the strength of the study is that it had a fairly high number of participants across several institutions.However, being conducted in one country and the sample not being randomly selected and being based on voluntariness can be considered as limitations.Conclusion our results show that the covid-19 pandemic has led to an increase in the anxiety levels of both female and male hcws, and this situation has negatively affected their sexual functions.Eroglu u, balci m, coser s, et al, impact of the covid-19 pandemic on the psychosexual functions of healthcare workers.J sex med 2022;19:182-187.

Journal: The journal of sexual medicine (2022)
Publication types: Journal Article
Biomechanical Effect of Coronal Alignment and Ligament Laxity in Total Knee Arthroplasty: A Simulation Study.

The purposes of this study were to develop a cruciate-retaining total knee arthroplasty musculoskeletal model, which enables the adjustment of ligament length and implant alignment; validate the model; and evaluate the effects of varus/valgus alignment adjustment and unbalanced medial/lateral ligament laxity during gait.A cruciate-retaining total knee arthroplasty musculoskeletal model was constructed and validated against thein vivocontact forces.This model was transformed to 2° varus/valgus alignment of femoral or tibial replacement models and 2° medial/lateral laxity models.The contact forces and ligament tensions of the adjusted models were calculated.The contact forces in the model showed good agreement with thein vivocontact forces.Valgus replacement alignment with balanced ligament models showed a lower contact force at the medial compartment than at the neutral alignment model, whereas the varus replacement alignment with balanced ligament models showed a greater contact force at the medial compartment and medial/posterior cruciate ligament tension.The medial laxity with neutral alignment model showed a similar contact force with decreased medial ligament tension compared to the balanced neutral alignment model, whereas the lateral laxity with the neutral alignment model showed a greater contact force and decreased lateral ligament tension.The cruciate-retaining total knee arthroplasty model was validated usingin vivocontact forces (r= 0.939) two degrees of valgus alignment adjustment with balanced ligament or neutral alignment with 2° of medial laxity can be safe without increasing contact force or ligament tension compared to neutral alignment with a balanced extension gap.However, 2° of varus alignment adjustment with balanced ligament or neutral alignment with 2° of lateral laxity may be unfavorable due to the overloading of the joints and knee ligaments.

Journal: Frontiers in bioengineering and biotechnology (2022)
Publication types: Journal Article
Solid Base Assisted Dual-Promoted Heterogeneous Conversion of PVC to Metal-Free Porous Carbon Catalyst.

Polyvinyl chloride (pvc) is widely used in daily life, but its waste has become a serious environmental problem.A solid base assisted low-temperature solvothermal dehalogenation was developed in this work to sustainably and efficiently transform pvc into high-value dimethylamine hydrochloride (dmacl) chemical and n,o co-doped carbon monolith with hierarchically porous structure.The synergistic promotion of solid-base catalyst and solvent decomposition with the removal of hcl can shift forward the chemical equilibrium to promote the dechlorination of pvc and increase the carbon yield.Meanwhile, the solid-base catalyst can also act as a pore-forming additive to fabricate the carbon monolith with hierarchical pores.Induced by the high specific surface area, hierarchical pores and n,o co-doped structure, the generated carbon monolith exhibits superior electrocatalytic performance towards h2evolution.These discoveries shed light on the design of synergistically coupled solvent and solid catalyst to promote the heterogeneous conversion of waste chlorinated plastics into high-value chemicals for a sustainable future.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (2022)
Publication types: Journal Article
Use of whole-cell bioreporters to assess bioavailability of contaminants in aquatic systems.

Water contamination has become increasingly a critical global environmental issue that threatens human and ecosystems' health.Monitoring and risk assessment of toxic pollutants in water bodies is essential to identifying water pollution treatment needs.Compared with the traditional monitoring approaches, environmental biosensingviawhole-cell bioreporters (wcbs) has exhibited excellent capabilities for detecting bioavailability of multiple pollutants by providing a fast, simple, versatile and economical way for environmental risk assessment.The performance of wcbs is determined by its elements of construction, such as host strain, regulatory and reporter genes, as well as experimental conditions.Previously, numerous studies have focused on the design and construction of wcb rather than improving the detection process and commercialization of this technology.For investigators working in the environmental field, wcb can be used to detect pollutants is more important than how they are constructed.This work provides a review of the development of wcbs and a brief introduction to genetic construction strategies and aims to summarize key studies on the application of wcb technology in detection of water contaminants, including organic pollutants and heavy metals.In addition, the current status of commercialization of wcbs is highlighted.

Journal: Frontiers in chemistry (2022)
Publication types: Journal Article;Review
Should cardiovascular comorbidities be a contraindication for pulmonary metastasectomy?

Limited information is available about the impact of cardiovascular comorbidities (cvc) on the postoperative course of patients undergoing pulmonary metastasectomy (pm).In this study, we aim to compare the postoperative morbidity, mortality, and the long-term survival of patients with and without cvc undergoing pm.Methods a retrospective monocentric study was conducted including 760 patients who underwent pm in curative intention.Patients were divided into two groups depending on the presence of cvc.Results the data from 164 patients with cvc (21.6%) and 596 patients without cvc (78.4%) were investigated.In both groups, zero in-hospital-mortality and limited 30-day mortality was detected.Postoperative complications occurred more often in patients with cvc (n=47, 28.7%vs.n=122, 20.5%, p=0.02).However, most of them were minor (n=37, 22.6%vs.n=93, 15.6%, p=0.03).The presence of multiple cvc (n=18 patients, 40%vs.n=28, 23.9%, p=0.04) and reduced left ventricular function (n=5, 62.5%vs.N=42, 27.1%, p=0.03) were identified as risk factors for postoperative morbidity.Patients with cvc showed reduced overall survival (5-year survival rate: 75.8%vs.68%, p=0.03).In the multivariate analysis lobectomy [hazard ratio (hr) 0.3, 95% confidence interval (ci): 0.1-0.8, p=0.02] and general vascular comorbidities (hr 2.1, 95% ci: 1.1-3.9, p=0.01) were identified as independent negative prognostic factors.Conclusions resection of pulmonary metastases can be performed safely in selected patients with stable cvc.The presence of cvc in patients undergoing pm is associated with reduced overall survival compared to patients without cvc in the long term follow up.However, a prolonged 5-year survival rate of 68% could be achieved.

Journal: Journal of thoracic disease (2022)
Publication types: Journal Article
Monostationarity and Multistationarity in Tree Networks of Goldbeter-Koshland Loops.

A major challenge in systems biology is to elicit general properties in the face of molecular complexity.Here, we introduce a class of enzyme-catalysed biochemical networks and examine how the existence of a single positive steady state (monostationarity) depends on the network structure, enzyme mechanisms, kinetic rate laws and parameter values.We consider goldbeter-koshland (gk) covalent modification loops arranged in a tree network, so that a substrate form in one loop can be an enzyme in another loop.Gk loops are a canonical motif in cell signalling and trees offer a generalisation of linear cascades which accommodate network complexity while remaining mathematically tractable.In particular, they permit a modular, recursive proof strategy which may be more widely applicable.We show that if each enzyme follows its own complex reaction mechanism under mass action kinetics, then any network is monostationary for all appropriate parameter values.If the kinetics is non-mass action with a plausible monotonicity requirement, and each enzyme follows the michaelis-menten mechanism, then monostationarity is preserved.Surprisingly, a single gk loop with a complex enzyme mechanism under non-mass action monotone kinetics can have more than one positive steady state (multistationarity).The broader interplay between network structure, enzyme mechanism and kinetics remains an intriguing open problem.

Journal: Bulletin of mathematical biology (2019)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.
National Emergency Resuscitation Airway Audit (NERAA): a pilot multicentre analysis of emergency intubations in Irish emergency departments.

There is paucity of literature on why and how patients are intubated, and by whom, in irish emergency departments (eds).The aim of this pilot study was to characterise emergency airway management (eam) of critically unwell patients presenting to irish eds.Methods a multisite prospective pilot study was undertaken from february 10 to may 10, 2020.This project was facilitated through the irish trainee emergency research network (itern).All patients over 16 years of age requiring eam were included.Eleven eds participated in the project.Data recorded included patients' demographics, indication for intubation, technique of airway management, medications used to facilitate intubation, level of training and specialty of the intubating clinician, number of attempts, success/complications rates and variation across centres.Results over a 3-month period, 118 patients underwent 131 intubation attempts across 11 eds.The median age was 57 years (iqr: 40-70).Medical indications were reported in 83% of patients compared to 17% for trauma.Of the 118 patients intubated, emergency medicine (em) doctors performed 54% of initial intubations, while anaesthesiology/intensive care medicine (icm) doctors performed 46%.The majority (90%) of intubating clinicians were at registrar level.Emergency intubation check lists, video laryngoscopy and bougie were used in 55, 53 and 64% of first attempts, respectively.The first pass success rate was 89%.Intubation complications occurred in 19% of patients.Em doctors undertook a greater proportion of intubations in eds with > 50,000 attendance (65%) compared to eds with < 50,000 attendances (16%) (p < 0.000).Conclusion this is the first study to describe eam in irish eds, and demonstrates comparable first pass success and complication rates to international studies.This study highlights the need for continuous eam surveillance and could provide a vector for developing national standards for eam and eam training in irish eds.

Journal: BMC emergency medicine (2022)
Publication types: Journal Article;Multicenter Study
Mexican descent college student risky sexual behaviors and alcohol use: The role of general and cultural based coping with discrimination.

This study investigates cultural and general coping strategies as potential protective or risk factors to risky sexual behaviors (rsbs) and alcohol use in the face of discrimination for mexican descent college students.participants:data collection was conducted from september 2016 to may 2017 and included 796 mexican descent emerging adults.methods:linear regressions were conducted to test main and interaction effects of discrimination, and general and cultural coping strategies on rsbs and alcohol use issues.results:higher discrimination experiences were not associated with rsbs or alcohol use issues.Only ethnicity-based coping was found to be a significant moderator to the relationships between discrimination and the outcome variables of rsbs and alcohol use issues.conclusions:this study has implications for the way mental health clinicians explore the intersection of ethnic identity and coping as a means of understanding the relationship among discrimination, rsbs, and alcohol use issues.

Journal: Journal of American college health : J of ACH (2021)
Publication types: Journal Article
Robust Quantum State Tomography Method for Quantum Sensing.

Reliable and efficient reconstruction of pure quantum states under the processing of noisy measurement data is a vital tool in fundamental and applied quantum information sciences owing to communication, sensing, and computing.Specifically, the purity of such reconstructed quantum systems is crucial in surpassing the classical shot-noise limit and achieving the heisenberg limit, regarding the achievable precision in quantum sensing.However, the noisy reconstruction of such resourceful sensing probes limits the quantum advantage in precise quantum sensing.For this, we formulate a pure quantum state reconstruction method through eigenvalue decomposition.We show that the proposed method is robust against the depolarizing noise; it remains unaffected under high strength white noise and achieves quantum state reconstruction accuracy similar to the noiseless case.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article
Prevalence and Self-Medication for Acne among Students of Health-Related Science Colleges at King Saud University in Riyadh Region Saudi Arabia.

And objectives:in saudi arabia, acne vulgaris is a very predominant ailment among adolescents, especially female university students, and self-medication has become a trend to manage this condition.To determine the prevalence of acne vulgaris among health care students and to access the scenario of its self-medication in light of students' knowledge, attitude, and practice towards it.materials and methods:this was an observational study conducted at king saud university, riyadh, kingdom of saudi arabia, from january 2022 to march 2022.The study was undertaken using a pre-structured questionnaire.results:a total of 550 university students were recruited and the incidence of acne was observed to be 78.5% (432 out of 550) with a female predominance.A total of 56.0% (244 of 432) students used self-medications for acne without a prescription and the most used prescription drugs were topical and oral antibiotics (38.1%), followed by isotretinoin (22.55), and topical adaplene (20.9%).Female students (n= 181, 63.5%) were significantly more likely to self-medicate compared to male students (n= 63, 42.9%,p≤ 0.001).Almost 60% of medical students had proper knowledge of medication for acne.conclusion:acne vulgaris is a highly prevalent condition among university students of saudi arabia and use of self-medication among acne sufferers is high.Education programs should be made to raise awareness about acne and its treatment.

Journal: Medicina (Kaunas, Lithuania) (2022)
Publication types: Observational Study;Journal Article
Pediatric Long-COVID: A Review of the Definition, Epidemiology, Presentation, and Pathophysiology.

Although children have been largely spared the most severe consequences of acute infection with sars-co v-2 virus, it is estimated that up to one-quarter of the more than 14 million children diagnosed as having coronavirus disease 2019 (covid-19) have developed persistent symptoms of fatigue, postexertional malaise, neurologic and cognitive symptoms, and other symptoms that interfere with activities of daily living for months after their initial illness.Pediatric postacute sequelae of covid-19 (p pasc), or long-covid, is a complex, heterogeneous, postviral condition involving multiple body systems and is likely attributable to several concurrent underlying physiologic processes, including damage from direct viral invasion, endovascular dysfunction and microthrombosis, viral persistence, and the development of autoimmunity.In this review, we explore the current state of the literature regarding definition, epidemiology, clinical presentation, and proposed pathophysiologic mechanisms of p pasc.[pediatr ann.2022;51(11):e416-e420.].

Journal: Pediatric annals (2022)
Publication types: Review;Journal Article
Bioinorganic Synthesis of Sodium Polytungstate/Polyoxometalate in Microbial Kombucha Media for Precise Detection of Doxorubicin.

In this study, we have developed a new platform of polyoxometalate as a biocompatible and electrosensitive polymeric biosensor for the accurate detection of doxorubicin.For this purpose, we used a green synthesis approach using tartaric acid, glutamic acid, and kombucha solvent.Thanks to its bioinorganic components, the biogenic approach can chemically modify and improve the performance of the biosensor, which was experimentally confirmed.Our results showed excellent sensitivity (175.72μa·μm-1·cm-2), low detection limit (dl, 8.12 n m), and low quantification limit (ql, 0.056μm) when the newly developed biosensor was used.The results also show that the biosynthesized biosensor has improved performance in detecting dox in the biological fluid with an accuracy of more than 99% depending on the components used, which underlines the high efficiency of the biosensor produced.Considering the body's physiological condition, the biosensor fabricated as a biocompatible component can show high efficiency.Therefore, its applicability for clinical use still needs to be studied in detail.

Journal: Bioinorganic chemistry and applications (2022)
Publication types: Journal Article
Ion Mobility Spectrometry of Superheated Macromolecules at Electric Fields up to 500 Td.

Since its inception in 1980s, differential or field asymmetric waveform ion mobility spectrometry (faims) has been implemented at or near ambient gas pressure.We recently developed faims at 15-30 torr with mass spectrometry and utilized it to analyze amino acids, isomeric peptides, and protein conformers.The separations broadly mirrored those at atmospheric pressure, save for larger proteins that (as predicted) exhibited dipole alignment at ambient but not low pressure.Here we reduce the pressure down to 4.7 torr, allowing normalized electric fields up to 543 td-double the maximum in prior faims or ims studies of polyatomic ions.Despite the collisional heating to ∼1000 °c at the waveform peaks, the proteins of size from ubiquitin to albumin survived intact.The dissociation of macromolecules in faims appears governed by the average ion temperature over the waveform cycle, unlike the isomerization controlled by the peak temperature.The global separation trends in this "superhot" regime extend those at moderately low pressures, with distinct conformers and no alignment as theorized.Although the scaling of the compensation voltage with the field fell below cubic at lower fields, the resolving power increased and the resolution of different proteins or charge states substantially improved.

Journal: Analytical chemistry (2021)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.
PSMA-targeted NIR probes for image-guided detection of prostate cancer.

Tumour-targeted near-infrared (nir) optical imaging is an emerging tool for the detection of malignant tissues.This modality can be useful in both diagnosis and intraoperative visualisation, to help defining tumour margins and allow a more precise removal of all the cancerous mass during surgery.In this context, we have developed a series of nir fluorescent probes that target the prostate-specific membrane antigen (psma), an established biomarker overexpressed in prostate cancer.Four new nir imaging agents were prepared by conjugating the well-known urea-based psma targeting module to the nir fluorophore cy7.5, with linkers of 7, 10, 17 and 24 atoms.The affinity of each probe for psma was assessed through competitive binding and ic50measurement in prostate cancer cells, using a previously reported psma-targeted nir probe (i.e.Psma-irdye800cw) as reference.The nir probe psma-cy7.5_2 demonstrated a high affinity for psma (i.e.Ic50= 58.8 n m) and was further studied in mouse xenograft models of prostate cancer, to assess its ability to image psma positive tumour tissues.While psma-cy7.5_2 out-performed psma-irdye800cw in vitro, its tumour accumulation in vivo was not as evident.Further micellar aggregation studies indicated that the relatively higher hydrophobic property of psma-cy7.5_2 may lower its bioavailability and tissue distribution following systemic injection, limiting its ability of targeting psma tumour in vivo.Nevertheless, the excellent binding capability of psma-cy7.5_2 renders this probe a valid lead for further structural optimisation to develop imaging analogues with high affinity and specificity for psma, as required for effective nir fluorescence-guided applications pre-clinically and clinically.

Journal: Colloids and surfaces. B, Biointerfaces (2022)
Publication types: Journal Article
Imaging of the post-treatment neck.

Post-treatment imaging of the neck is complex.It is important to have an understanding of the expected treatment related appearances as well as the possible complications.Common findings after radiation therapy include generalised soft-tissue oedema and thickening of the skin and platysma muscle.There are a number of complications of radiation that may be seen on imaging, including osteoradionecrosis, chondronecrosis, and accelerated atherosclerosis.Surgical procedures are variable depending on the primary tumour site and extent.The use of flap reconstructions can further complicate the imaging appearances.Any new nodule of enhancement or bone/cartilage erosion should raise concern for tumour recurrence.It is also important to assess for nodal recurrence.A standardised approach to reporting may help to increase accuracy and guide treatment decisions.

Journal: Clinical radiology (2020)
Publication types: Journal Article;Review