syedzayyan/paper_mill_benchmark huggingface dataset:
Text Mining of Movie Animation User Comments and Video Artwork Recommendation Based on Machine Learning

Video artworks are closely linked with the development of contemporary technology.Therefore, it is widely used in various fields of social life.Video art has become one of the main media forms of contemporary art.In the practice of art teaching, how to combine the existing content of traditional art teaching with video technology and how to understand the inner connection between traditional aesthetics and technological aesthetics have become issues that workers in the new era must think about and pay attention to.As a typical case of influencing works of art, movie animation is loved by the majority of young people.In order to quantify the application effect of machine learning in video art and film animation text mining, this paper conducts prediction research and analysis on several main aspects of color features involved in film animation.By introducing three typical machine learning methods, this paper analyzes the distribution law of the color features of film animation from the perspective of machine learning and its influence on artistic texts.Specifically, the paper uses machine learning methods as a carrier to predict the performance of multiple main modules of color features in movie animation.The prediction results show that the square of the correlation coefficient corresponding to the extreme learning machine is the largest, and the root mean square error, the mean absolute percentage error, and the median absolute error are the smallest, which shows that the extreme learning machine has the best prediction effect.Therefore, it corresponds to the best prediction.In addition, the comparison between the predicted data and the measured data shows that the relationship between the two is approximately a linear function of y = x.At the same time, the fitting calculation shows that the predicted data corresponding to the two main modules of the main color and the color structure in the color feature exhibit a good functional relationship of polynomial functions.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Psychological Nursing Effect of Patients with Gynecological Malignant Tumor

To analyze the psychological nursing effect of patients with gynecological malignant tumor.Method .A total of 104 patients with gynecological malignant tumor receiving chemotherapy in our hospital from december 2019 to november 2020 were selected and randomly divided into observation group and control group with 52 cases each.Patients in the control group were treated with routine nursing of gynecological malignant tumor chemotherapy.The observation group applied psychological nursing methods on the basis of the control group, and psychological status, quality of sleep, quality of life, treatment coordination, and adverse reactions were compared between the two groups.Results .There was no difference in anxiety and depression scores ( p &gt; 0.05), the postintervention score was lower than the preintervention score, and the reduction was more significant in the observation group ( p &lt; 0.05).After intervention, psqi scores of the two groups of subjects were significantly lower than before intervention ( p &lt; 0.05), subjects in the observation group were significantly lower than those in the control group, and the difference was statistically significant ( p &lt; 0.05).After intervention, the total score of fact‐b scale was significantly higher in the observation group than in the control group, and the difference was statistically significant ( p &lt; 0.05).After the implementation of psychological nursing, the degree of tumor treatment cooperation of observation group was higher than the control group ( p &lt; 0.05).After intervention, there was no statistically significant difference in hematology, allergic reaction, or hair loss between the two groups ( p &gt; 0.05).The incidence of gastrointestinal and neurological adverse events in the observation group was significantly lower than that in the control group, and the difference was statistically significant ( p &lt; 0.05).Conclusion .The psychological state of patients with gynecological malignant tumor mainly included anxiety and terror and so on.Through psychological counseling, it could effectively alleviate the abovementioned bad psychology, improve the cooperation of patients with tumor treatment, and reduce the occurrence of patients’ adverse reactions.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Psychological Consultation and Health Analysis Method for Artificial Intelligence Multidecision Support

With the increase in market economy and life competition, mental health problems are particularly prominent in today’s society.This is also an important reason for the sudden increase in extreme events.The frequent occurrence of violent incidents and depressive incidents is mainly caused by major problems in mental health.They accumulate greater pressure in life or study, which can easily lead to mental health problems.However, mental health problems are difficult to detect up front.When the mental health problem is more serious, they will seek a psychological counselor or a way to release stress to solve the mental health problem.Only a small number of people will take extreme measures, which will cause social or family losses.Artificial intelligence methods have better advantages in dealing with nonlinear relationships of features.This study uses a convolutional neural network (cnn) and long short-term memory (lstm) methods in artificial intelligence methods to study the characteristics of psychological counseling and health.The research results show that cnn and lstm methods can accurately predict the characteristics of psychological counseling and health, which can do certain forecasting work for discovering people’s mental health problems.The maximum prediction error of cnn and lstm methods in predicting the characteristics of psychological counseling and health is only 2.64%.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Protective Mechanism of Trimetazidine in Myocardial Cells in Myocardial Infarction Rats through ERK Signaling Pathway

To study the protective effect of trimetazidine on myocardial cells in rats with myocardial infarction and explore its effect on erk signaling pathway.Methods .40 sd rats were randomly divided into the sham operation group, model group, low‐dose group, and high‐dose group (intra‐abdominal injection of trimetazidine 5 mg/kg and 10 mg/kg, respectively), construction of rat myocardial infarction model by coronary artery left anterior descending artery ligation.7 days after surgery, the survival rate and cardiac function of each group of rats were recorded.The myocardial infarct size was detected by ttc staining.The apoptosis level of rat cardiomyocytes was detected by tunel staining.The content of ros in rat cardiomyocytes was detected by dcfh‐da.Western‐blot was used to detection of caspase‐3, bcl‐2/bax, and erk signaling pathway‐related proteins in myocardial tissue.Results .Compared with the model group, the survival rate of the rats in the low‐dose group and the high‐dose group was significantly increased ( p &lt; 0.01), the cardiac function was significantly improved ( p &lt; 0.01), the myocardial infarct size was significantly decreased ( p &lt; 0.01), the level of apoptosis was significantly decreased ( p &lt; 0.01), the content of ros in cardiomyocytes was significantly decreased ( p &lt; 0.01), the protein expression of caspase‐3 and nf‐ κ b in cardiomyocytes was significantly decreased ( p &lt; 0.01), and the expression of bcl‐2/bax and p‐erk were significantly increased ( p &lt; 0.01).Conclusion .Trimetazidine can activate erk signaling pathway in cardiomyocytes of rats with myocardial infarction, increase the expression of p‐erk, decrease the content of ros in cardiomyocytes, decrease the expression of apoptotic proteins, reduce myocardial infarct size, improve cardiac function, and increase myocardial function.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Protease-Activated Receptor 1 Contributes to Microcirculation Failure and Tubular Damage in Renal Ischemia-Reperfusion Injury in Mice

Ischemia‐reperfusion‐ (ir‐) induced kidney injury is difficult to avoid during renal transplantation and robot‐assisted partial nephrectomy.Renal ir injury is characterized by tubular damage, microcirculation failure, and inflammation, which coordinately augment renal injury; however, no specific treatment is available for these conditions.Protease‐activated receptor‐1 (par‐1) and its ligand, thrombin, are involved in coagulation and were shown to be associated with epithelial cell injury.Here, we hypothesized that par‐1 exaggerated renal ir‐induced tubular cell damage and microcirculation failure and that pharmacological inhibition of par‐1 by q94 could prevent these injuries.Renal warm ir increased the expression of par‐1 in the renal tubules.Q94 attenuated renal ir‐induced changes and histopathological damage.Microcirculation failure analyzed by congestion in the histopathology and blood cell flow examined by intravital multiphoton microscopy were suppressed by q94 treatment.Q94 also dramatically increased tubular cell proliferation despite the lower renal damage.Thrombin suppressed cell proliferation and induced apoptosis in the tubules; these effects were prevented by q94 treatment.Taken together, par‐1 was associated with renal ir injury.Inhibition of par‐1 ameliorated injury possibly by improving renal microcirculation and tubular cell survival/proliferation.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Propranolol Participates in the Treatment of Infantile Hemangioma by Inhibiting HUVECs Proliferation, Migration, Invasion, and Tube Formation

Infantile hemangiomas (ihs) are the most common benign tumors in infancy.The purpose of this study was to study the effects of propranolol on the function of human umbilical vein endothelial cells (huvecs), in order to preliminarily elucidate the mechanism of propranolol in the treatment of ihs.Methods .Huvecs were treated with different concentrations of propranolol (30 μ m, 60 μ m, 90 μ m, and 120 μ m) with or without vegf.Their proliferation, migration, invasion, adhesion, and tube formation ability were tested by using cck‐8, wound healing assay, transwell, cell adhesion assay, and tube formation assay.The expressions of huvecs angiogenesis signaling molecules p erk/erk, p akt/akt, p‐m tor/m tor, and p fak/fak were detected by western blot.Results .Compared with the control group, propranolol could significantly inhibit the proliferation, migration, invasion, adhesion, and tube formation of huvecs.Further studies showed that it could not only inhibit the migration, invasion, and tube formation ability of huvecs after vegf induction but also inhibit the phosphorylated protein expressions of angiogenesis‐related signaling molecules like akt, m tor, erk, and fak in huvecs, with a concentration‐dependent inhibitory effect.Conclusion .Propranolol can inhibit the proliferation, migration, invasion, adhesion, and tube formation of hemangioma endothelial cells; block vegf‐mediated angiogenesis signaling pathway; suppress the expressions of downstream angiogenesis‐related signaling molecules; and ultimately achieve the effect of treatment of ihs.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Promotion of Differentiating Bone Marrow Mesenchymal Stromal Cells (BMSCs) into Cardiomyocytes via HCN2 and HCN4 Cotransfection

Investigation of the influences hcn2 and hcn4 has on bone marrow mesenchymal stromal cells (bmscs) on cardiomyocyte differentiation.Methods.Miniature adult pigs were used for bone marrow extraction and isolation of bmscs.The identification of these bmscs was done by using flow cytometry for the detection of expressed surface antigens cd45, cd11b, cd44, and cd90.Using hcn2 and hcn4 genes cotransfected into bmscs as group hcn2+hcn4 while myocardial induction solution was used to induced bmsc differentiation in the bmsc induction group.Myocardial marker proteins α ‐actin and c tn t were detected by immunofluorescence staining, while α ‐actin, c tn t, and desmin myocardial marker proteins expressed were detected by western blot.The whole‐cell patch‐clamp technique was used to identify and detect cellular hcn2 channels, hcn4 channel current activation curve, and the inhibitory effect of cs cl on heterologous expression currents.Results.Flow cytometry results showed that cd45 and cd11b were expressed negatively while cd90 and cd44 were positive.Post hcn2 and hcn4 gene transfection, immunofluorescence staining, and western blot showed significantly increased hcn2, hcn4, α ‐actin, and c tn t expressed in group hcn2+hcn4 were, which could be compared to the expression levels in the bmsc‐induced group.The hcn2+hcn4 group was able to document cell membrane channel ion currents that were similar to if properties.Conclusion.Hcn2 and hcn4 overexpression can considerably enhance the msc ability to differentiate into cardiomyocytes in vitro and restore the ionic current.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Progress of Statin Therapy in the Treatment of Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (ipf) is a type of interstitial lung disease (ild) characterized by the proliferation of fibroblasts and aberrant accumulation of extracellular matrix.These changes are accompanied by structural destruction of the lung tissue and the progressive decline of pulmonary function.In the past few decades, researchers have investigated the pathogenesis of ipf and sought a therapeutic approach for its treatment.Some studies have shown that the occurrence of ipf is related to pulmonary inflammatory injury; however, its specific etiology and pathogenesis remain unknown, and no effective treatment, with the exception of lung transplantation, has been identified yet.Several basic science and clinical studies in recent years have shown that statins, the traditional lipid-lowering drugs, exert significant antifibrotic effects, which can delay the progression of ipf and impairment of pulmonary function.This article is aimed at summarizing the current understanding of the pathogenesis of ipf, the progress of research on the use of statins in ipf models and clinical trials, and its main molecular targets.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Review Article;
Prognostic Diagnosis for Breast Cancer Patients Using Probabilistic Bayesian Classification

The diagnosis and treatment of patients in the healthcare industry are greatly aided by data analytics.Massive amounts of data should be handled using machine learning approaches to provide tools for prediction and categorization to support practitioner decision‐making.Based on the kind of tumor, disorders like breast cancer can be categorized.The difficulties associated with evaluating vast amounts of data should be overcome by discovering an efficient method for categorization.Based on the bayesian method, we analyzed the influence of clinic pathological indicators on the prognosis and survival rate of breast cancer patients and compared the local resection value directly using the lymph node ratio (lnr) and the overall value using the lnr differences in effect between estimates.Logistic regression was used to estimate the overall lnr of patients.After that, a probabilistic bayesian classifier‐based dynamic regression model for prognosis analysis is built to capture the dynamic effect of multiple clinic pathological markers on patient prognosis.The dynamic regression model employing the total estimated value of lnr had the best fitting impact on the data, according to the simulation findings.In comparison to other models, this model has the greatest overall survival forecast accuracy.These prognostic techniques shed light on the nodal survival and status particular to the patient.Additionally, the framework is flexible and may be used with various cancer types and datasets.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Principal Component and Path Analysis for Trait Selection Based on the Assessment of Diverse Lentil Populations Developed by Gamma-Irradiated Physical Mutation

Lentil is a notable legume crop valued for its high protein, vitamin, mineral, and amino acid (lysine and tryptophan) content.This crop has a narrow genetic base due to the formation of gene pool barriers during interspecific hybridization within and across species.Mutagenesis may be seen as a novel and alternative breeding technique for the production of new diversity.For the identification of new alleles, the creation of mutants followed by selection in subsequent generations would be necessary.Induction of mutation in lentil cv.Moitree by gamma rays therefore produced high variation for the majority of quantitative measures examined.Henceforth, principal component analysis (pca) and path coefficient analysis were conducted to identify and exclude redundant mutant genotypes with similar traits as the success of breeding is dependent on understanding the relationship between morpho‐agronomic traits and seed yield.As shown by the findings of this research, the total quantity of pods per mutant plant should be given considerable priority.The identified mutant genotypes, such as lines 24, 43, 28, 33, and 10, may be used as parents in future breeding or released directly following trials.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Platelet-Rich Plasma-Derived Exosomal USP15 Promotes Cutaneous Wound Healing via Deubiquitinating EIF4A1

Epithelial regeneration is an essential wound healing process, and recent work suggests that different types of exosomes (exos) can improve wound repair outcomes by promoting such epithelial regeneration.Platelet‐rich plasma (prp) is known to facilitate enhanced wound healing, yet the mechanisms underlying its activity are poorly understood.To explore these mechanisms, we first isolated prp‐derived exos (prp‐exos).Using immortalized keratinocytes (ha ca t cells) treated with pbs, prp, or prp‐exos, we conducted a series of in vitro cell counting kit‐8 (cck‐8), ed u, scratch wound, and transwell assays.We then established a wound defect model in vivo in mice and assessed differences in the m rna expression within these wounds to better understand the basis for prp‐mediated wound healing.The functions of prp‐exos and usp15 in the context of wound healing were then confirmed through additional in vitro and in vivo experiments.We found that prp‐exos effectively promoted the in vitro proliferation, migration, and wound healing activity of ha ca t cells.Usp15 was further identified as a key mediator through which these prp‐exos were able to promote tissue repair both in vitro and in vivo .At a mechanistic level, usp15 enhanced the functional properties of ha ca t cells by promoting eif4a1 deubiquitination.Thus, prp‐exos and usp15 represent promising tools that can promote wound healing via enhancing epithelial regeneration.

Journal: Oxidative Medicine and Cellular Longevity (2021)
Publication types: Research Article;
Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice

Chronic oxidative stress eventually leads to protein aggregation in combination with impaired autophagy, which has been observed in age‐related macular degeneration.We have previously shown an effective age‐related macular degeneration disease model in mice with nuclear factor‐erythroid 2‐related factor‐2 (nfe2l2) knockout.We have also shown pinosylvin, a polyphenol abundant in bark waste, to increase human retinal pigment epithelium cell viability in vitro .In this work, the effects of commercial natural pinosylvin extract, retinaritm, were studied on the electroretinogram, optical coherence tomogram, autophagic activity, antioxidant capacity, and inflammation markers.Wild‐type and nfe2l2 knockout mice were raised until the age of 14.8 ± 3.8 months.They were fed with either regular or retinaritm chow (141 ± 17.0 mg/kg/day of pinosylvin) for 10 weeks before the assays.Retinaritm treatment preserved significant retinal function with significantly preserved a‐ and b‐wave amplitudes in the electroretinogram responses.Additionally, the treatment prevented thinning of the retina in the nfe2l2 knockout mice.The nfe2l2 knockout mice showed reduced ubiquitin‐tagged protein accumulation in addition to local upregulation of complement factor h and antioxidant enzymes superoxide dismutase 1 and catalase.Therefore, the treatment in the nfe2l2 ko disease model led to reduced chronic oxidative stress and sustained retinal function and morphology.Our results demonstrate that pinosylvin supplementation could potentially lower the risk of age‐related macular degeneration onset and slow down its progression.

Journal: Oxidative Medicine and Cellular Longevity (2021)
Publication types: Research Article;
Phyto-Extract-Mediated Synthesis of Silver Nanoparticles (AgNPs) and Their Biological Activities

Nanotechnology finds broad applications in the field of nanomedicine, an emerging new field used for diagnosis, treatment, prevention of diseases, and improvement of health.Objectives .To synthesize silver nanoparticles (ag nps) from withania somnifera and fagonia indica and to carry out their antimicrobial, insecticidal, and phytotoxic activities, a step toward the new range of nanomedicines.Methods .Silver nanoparticles were synthesized from withania somnifera and fagonia indica by chemical reduction method, and further biological activities of these nanoparticles were compared with crude methanolic extract, prepared through cold maceration process, at the concentration of 50 mg/ml.Results .Among all tested bacterial pathogens, crude extract of w.Somnifera showed a statistically high significant inhibition zone in millimeter against pseudomonas aeruginosa (21; p &lt; 0.01).Ag nps showed highly significant result against streptococcus pneumonia (14; p &lt; 0.01).In comparison with crude extracts, ag nps showed statistically significant ( p &lt; 0.01) results against s.Pneumonia (ag nps, 14; crude, 8.33 mm).Crude extract showed significant inhibition zone against two bacterial strains, p.Aeruginosa (crude, 21; ag nps, 11.67 mm) and klebsiella pneumoniae (crude, 11.33; ag nps, 8 mm).Crude extracts of f.Indica showed the significant activity against vibrio cholera ( p &lt; 0.01; 11.33 mm).Silver nanoparticles of f.Indica exhibited the highest significant activity against aspergillus flavus and fusarium oxysporum while ag nps of w.Somnifera were active only against a.Flavus .Extracts of w.Somnifera and f.Indica showed increasing phytotoxic activity with increasing concentrations.The highest significant inhibition was obtained for crude extract (46.7) and ag nps (45.7) of f.Indica at 1000 μ g/ml.Insecticidal activity of crude and ag nps of both plants showed significant inhibition against all tested insects with increasing time intervals, and the highest significant result was obtained at 72 hours with a value of p &lt; 0.01 except t.Castaneum .Conclusions .Both crude and ag nps showed potent activity; however, in comparison, silver nanoparticles showed slightly enhanced activity.Crude and ag nps of both plants showed good phytotoxic and insecticidal inhibition.Antimicrobial studies of ag nps on diseases causing pathogens open a door for new antimicrobial agents and could be the answer to antibiotic resistance after further analysis.

Journal: BioMed Research International (2022)
Publication types: Research Article;