syedzayyan/paper_mill_benchmark huggingface dataset:
Traditional Chinese Medicine Is Associated with Reduced Risk of Readmission in Rheumatoid Arthritis Patients with Anemia: A Retrospective Cohort Study.

This study aimed to analyze the effect of traditional chinese medicine (tcm) on the risk of readmission for rheumatoid arthritis (ra) patients with anemia.Methods in this study, 893 hospitalized ra patients were followed up by telephone.A retrospective cohort study was conducted using propensity score matching (psm).The cox proportional hazards model was used to assess the influence of various factors on the risk of readmission for ra patients with anemia.The kaplan-meier survival curve was utilized to analyze the effect of tcm intervention time on readmission.Results the incidence of anemia was 58.08% (471/811) in ra patients.After 1 : 1 psm, 328 ra patients with anemia and 328 ra patients without anemia were finally included in our study.The readmission rate of anemia patients was higher than that of patients without anemia (p 12 months) compared with the low-exposure subgroup (tcm ≤ 12 months) (log-rank p=0.016).Conclusion tcm, as a protective factor, is associated with a reduced risk of readmission in ra patients with anemia.

Journal: Evidence-based complementary and alternative medicine : eCAM (2022)
Publication types: Journal Article
Vegetable Extracts and Nutrients Useful in the Recovery fromHelicobacter pyloriInfection: A Systematic Review on Clinical Trials.

Helicobacter pylori(h.Pylori) infections affect almost half of the world's population, with gradually increasing incidence in developed countries.Eradication of h.Pylorimay provide significant benefits to the affected individual by healing a number of gastrointestinal and extra-digestive disorders.But due to increased microbial resistance and lack of patient adherence to the therapy, the eradication rate of h.Pyloriis below 80% with current pharmacological therapies.The usage of botanicals for their therapeutic purposes and medicinal properties have been increased in last decades.They can be use as alternative h.Pyloritreatments, especially against drug-resistant strains.Epidemiological studies have revealed that people with lower vegetable and micronutrient intake may be at increased risk of h.Pyloriinfection.We have undertaken a review of clinical trials to evaluate the efficacy of vegetable extracts and micronutrients in patients with h.Pylori.Various databases, such as google scholar, pub med, scopus, web of science, and the cochrane library, were searched for the articles published in english.A total of 24 clinical studies (15 for vegetable extracts and 9 for micronutrients) were selected to be reviewed and summarized in this article.Vegetable extracts (broccoli sprouts, curcumin, burdock complex, and nigella sativa) and micronutrients (vitamin c and e) were not found to be as effective as single agents in h.Pylorieradication, rather their efficacy synergized with conventional pharmacological therapies.Conversely, gut gard was found to be significantly effective as a single agent when compared to placebo control.

Journal: Molecules (Basel, Switzerland) (2021)
Publication types: Journal Article;Systematic Review
Challenges on Multiple Endpoints in Clinical Trials: An Industry Survey in Japan.

Two issues on clinical trials with multiple endpoints were surveyed: (1) the terminology of multiple endpoints, relationship between rare events and endpoints, and differences in multiplicity adjustment between regions; and (2) the current practice on multiplicity adjustment and sample size calculation.This article provides a summary of the results of a survey on the first issue.Methods the survey was conducted among 63 members of the japan pharmaceutical manufacturers association from october to november 2017.Results thirty-five companies based in japan and 12 companies based in other countries, 47 companies in total, responded to the survey.The terms co-primary endpoints, secondary endpoint, and composite endpoint were used in a variety of ways.An endpoint for a clinically most important event that is expected to occur rarely differed between regions.Although the pharmaceuticals and medical devices agency did not demand multiplicity adjustment, it was considered in clinical trials with multiple endpoints for approval in japan.Conclusions the use of terminology differed from the definition in the food and drug administration guidance and the european medicines agency guideline.There remain challenges on a clinically most important event that is expected to occur rarely and multiplicity adjustment in clinical trials with multiple endpoints.

Journal: Therapeutic innovation & regulatory science (2020)
Publication types: Journal Article
An Imperative for the National Public Health School in Burkina Faso to Promote the Use of Information and Communication Technologies in Education During the COVID-19 Pandemic: Critical Analysis.

Several studies have reported the positive impact of information and communication technologies (icts) on academic performance and outcomes.Although some equipment is available, the icts for education at the national public health school (nphs) of burkina faso have many shortcomings.These shortcomings were clearly revealed during the search for responses to the crisis caused by the covid-19 pandemic.Indeed, to curb the spread of covid-19, some measures were taken, such as closure of educational institutions.This resulted in a 2.5-month suspension of educational activities.Despite its willingness, the nphs was unable to use icts to continue teaching during the closure period of educational institutions.Objective in this paper, we aim to propose practical solutions to promote ict use in teaching at the nphs by analyzing the weaknesses and challenges related to its use.Methods we conducted a critical analysis based on information from the gray literature of nphs.This critical analysis was preceded by a review of systematic reviews on barriers and facilitating factors to using icts in higher education and a systematic review of ict use during the covid-19 pandemic in higher education.An ict integration model and a clustering of ict integration factors guided the analysis.Results the weaknesses and challenges identified relate to the infrastructure and equipment for the use of icts in pedagogical situations in face-to-face and distance learning; training of actors, namely the teachers and students; availability of qualified resource persons and adequate and specific financial resources; motivation of teachers; and stage of use of icts.Conclusions to promote the use of icts in teaching at the nphs, actions must be performed to strengthen the infrastructure and equipment, human resources, the skills of actors and the motivation of teachers in the pedagogical use of icts.

Journal: JMIR medical education (2021)
Publication types: Journal Article
Immune Thrombocytopenia Induced by the Chimpanzee Adenovirus-Vectored Vaccine against SARS-CoV-2 Infection.

We present a case of immune thrombocytopenia (itp) induced by the chimpanzee adenovirus-vectored vaccine, without evidence of thrombosis, eight days after vaccine administration.The thrombocytopenia condition improved after administering steroid treatment.This adenovirus vaccine had been reported to induce rare side effects, such as immune thrombotic thrombocytopenia.This case report showed that it could also induce immune thrombocytopenia without the presence of thrombosis.Therefore, we should be cautious of this rare side effect as global vaccine administrations against coronavirus disease increase.

Journal: Vaccines (2021)
Publication types: Case Reports;Journal Article
Common Type 2 Diabetes Genetic Risk Variants Improve the Prediction of Gestational Diabetes.

Gestational diabetes mellitus (gdm) is a carbohydrate intolerance that occurs in women during pregnancy.The aims of this study were to develop a model to predict the risk of gdm development using common clinical parameters and selected genetic polymorphisms and to analyse the performance of the model using receiver operator characteristic (roc) curves.Roc analysis was used to examine whether the evaluation of genetic polymorphisms may enhance the accuracy of gdm prediction in comparison to using common clinical risk factors only.This study included 204 pregnant women with gdm and 207 pregnant women with normal glucose tolerance.The diagnosis of gdm was based on a 75 g oral glucose tolerance test at 24-28 weeks gestation.The difference between the auc of roc curves for the model 1 including only age and bmi and the model 2 also including 8 genetic polymorphisms was highly significant (p=0.0001) in favour of model 2 (0.090±0.023).Moreover, the additional use of 8 genetic polymorphisms may increase both the sensitivity and specificity of gdm prediction by 10%.The results of this study indicate that the use of 8 genetic polymorphisms associated with carbohydrate and lipid metabolism and type 2 diabetes [ptgs2(cox2) rs6681231,fads1rs174550,hnf1brs4430796,adipoqrs266729,il18rs187238,ccl2rs1024611,hhexrs5015480 and cdkn2a/2brs10811661] together with clinical risk factors (bmi and age) may significantly improve the prediction of gdm.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (2019)
Publication types: Journal Article
Tunable concentration-dependent upconversion and downconversion luminescence in NaYF4: Yb3+, Er3+@ NaYF4: Yb3+, Nd3+core-shell nanocrystals for a dual-mode anti-counterfeiting imaging application.

Lanthanide-doped luminescent nanocrystals display both upconversion luminescence (ucl) and downconversion luminescence (dcl) properties, which offer potential applications in the second near-infrared window (nir-ii) images and biology sensors.Both ucl and dcl are sensitive to concentrations of activators.However, few works reveal the mechanism of concentration-dependent ucl and dcl.Herein, we synthesize core-shell upconversion nanocrystals (ucncs) na yf4: yb3+(20%), er3+(2%)@na yf4: yb3+(x%), nd3+(y%) with varying concentration of nd and yb ions.The ucl and dcl spectra are recorded under excitation of 980 nm and 808 nm lasers.The results indicate that the luminescence of core-shell ucncs is influenced by the non-radiative rate between activators (yb3+and nd3+) and the back energy transfer rate from er3+ions to activators.Ucl tends to be obtained at a relatively low concentration of yb3+and nd3+ions (about 5%), whereas nir emission tends to be obtained at a relatively high concentration of yb3+and nd3+ions (not higher than 20%).Dual-mode anti-counterfeiting imaging is successfully fabricated using core-shell ucncs, which can be detected and distinguished by visible and infrared detectors.The visible versus infrared brightness of dual-mode anti-counterfeiting imaging can be tuned by varying the concentration of activators (yb3+, nd3+).Our work demonstrates concentration-dependent ucl and dcl in core-shell ucncs, which provides reference to obtain nir emission in the nir-ii region and adds encrypted dimensions for anti-counterfeiting patterns in the field of file encryption.

Journal: Optics letters (2022)
Publication types: Journal Article
Hemodynamics and bio-mechanics of morphologically distinct saccular intracranial aneurysms at bifurcations: Idealised vs Patient-specific geometries.

Understanding the factors that influence the rupture of aneurysms is of primary concern to the clinicians, who are grappled with patient management.It is important to know how the relation between morphological features of the cerebral aneurysm, and the mechanical stresses on the containing arterial walls are influenced by the hemodynamic forces.Present study investigates three different shapes, which have been identified correspondingly in patient-specific scenarios as well.The primary objective is to categorize the bifurcation aneurysms into standard shapes such as, spherical, beehive and pear-shaped, based on patient-specific clinical studies and further compare and contrast the model aneurysms with the patient specific configurations, for their hemodynamic factors as well as the attendant stresses on the wall.Methods computational fluid dynamic simulations are performed accounting for the fluid-structure interaction (fsi) effects between the flowing fluid and the containing vessel wall.Blood is assumed to be newtonian, while the arterial walls are assumed to be linearly elastic.A commercial solver is used for performing detailed calculations.Hemodynamic and bio-mechanical rupture predictions are carried out for the three different shapes.Observations derived from the idealised simulations are compared and contrasted against their patient-specific counterparts.Results from detailed numerical simulations, it was observed that pear-shaped aneurysms exhibit large re-circulation bubble and flow stagnation zone, with higher residence time for the particles, which may lead to atherosclerotic lesions.Beehive shape allows for maximum flow into the aneurysmal sac with concentrated jet impinging on the dome, leading to high values of maximum wss (mwss) resulting in great propensity to form a secondary bleb.However, flow field inside a spherical aneurysm is found to be stable with fewer vortices, and nearly uniform distribution of wall stresses are observed though-out the sac, which perhaps signifies hemodynamically and bio-mechanically stable condition.Conclusion categorizing patient-specific intracranial aneurysms into standard shapes viz, spherical, beehive and pear could generalize the process of prediction of hemodynamic and bio-mechanical rupture indicators.Comparative assessment of the flow field and stresses reported from the simulations on idealised models, with corresponding patient-specific simulations reveal that, these studies could aid in understanding the generalised shape dependence of hemodynamic and bio-mechanical behaviour of aneurysms.

Journal: Computer methods and programs in biomedicine (2022)
Publication types: Journal Article
Upper Thermal Tolerance Indicated by CTmaxFails to Predict Migration Strategy and Timing, Growth, and Predation Vulnerability in Juvenile Brown Trout (Salmo trutta).

Partial migration is common in a variety of taxa and has important ecological and evolutionary implications, yet the underlying factors that lead to different migratory strategies are not clearly understood.Given the importance of temperature in serving as a cue for migration, along with its role in regulating metabolism, growth, reproduction, and survival, we examined how intraspecific variation in critical thermal maximum (ctmax) values influenced migratory strategy (residency vs.Migration), timing of migration, growth, and predation vulnerability in a wild population of partially anadromous juvenile brown trout (salmo trutta).Using passive integrated transponder telemetry and mark-recapture techniques, we identified individuals that out-migrated to sea, assumed residency, and were predated by cormorants several months later.Acute thermal stress induced by conducting ctmaxtrials did not affect the final fate of assayed fish compared with controls.We found that mass and body condition predicted ctmaxand migration timing, but ctmaxfailed to predict migratory strategy or timing, growth (of resident fish), or predation vulnerability.Although there may be links between mass, thermal tolerance, and migration strategy, the relationship between ctmaxand migration remains unclear.The role of upper thermal tolerance in influencing life-history strategies should not be neglected, however, as alternative indicators of thermal tolerance could be further explored.The high degree of variation in ctmaxestimates warrants additional investigation of how increasingly prevalent high-temperature events might drive selection toward thermally tolerant extremes, which is particularly relevant in a rapidly warming world.

Journal: Physiological and biochemical zoology : PBZ (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Ginsenoside Rk1 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease via activating silence information regulator 3-mediated Nrf2/HO-1 signaling pathway.

S:ginsenoside rk1, a novel ginsenoside isolated from red ginseng, has anti-inflammatory and anti-tumor activities.This study was designed to elucidate the role of rk1 in anin vitro1-methyl-4-phenylpyridinium (mpp+) cell model and anin vivo1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) of parkinson's disease (pd).methods:the grasping test, pole-climbing test, and rotarod test were performed to measure the effects of rk1 on mptp-induced motor disorders.The expression of tyrosine hydroxylase (th) and iba-1 were evaluated by western blotting.Cck-8 and flow cytometry assays were utilized to assess cell viability and apoptosis.Reactive oxygen species (ros), lactate dehydrogenase (ldh), and superoxide dismutase (sod) were detected to analyze the effects of rk1 on oxidative stress.The levels of inflammatory cytokines were evaluated by enzyme-linked immunosorbent assay (elisa).results:the results showed that rk1 allayed motor deficit elicited by mptp in a mouse model.Rk1 administration augmented tyrosine hydroxylase (th) expression in the brain striatum and substantia nigra (sn) of mptp-treated mice.Moreover, rk1 pretreatment promoted viability and suppressed apoptosis in mpp+-induced pc-12 cells.Further, rk1 also attenuated mpp+-stimulated oxidative stress and inflammatory response in pc-12 cells.Besides, rk1 augmented the level of sirt3, and sirt3 deletion counteracted rk1-induced repression on mpp+-elicited apoptosis, oxidative stress, and inflammatory response in pc-12 cells via modulating the nuclear factor erythroid 2-related factor 2 (nrf2)/heme oxygenase-1 (ho-1) pathway.conclusions:rk1 might exert neuroprotective effects against mpp+/mptp-induced neurotoxicity via activating sirt3-mediated nrf2/ho-1 signaling.Rk1 might be a promising candidate against pd.

Journal: Human & experimental toxicology (2023)
Publication types: Journal Article
Pharmacogenetics of common SNP affecting drug metabolizing enzymes: comparison of allele frequencies between European and Malaysian/Singaporean.

Compared to europe, data on genetic variation in genes transcribing drug metabolizing enzymes among asian is limited due to ethnic diversity.Here we compare frequencies for clinically relevant single nucleotide polymorphism (snp) commonly observed in drug metabolizing enzymes between european and malaysian/singaporean.Minor allele frequencies (maf) for the indicated snps for european, south asian and east asian populations were obtained from the ncbi website ( the snp prevalence among malaysian/singaporean was characterized from gene association studies.Generally, some snps in cyp2d6and cyp2c19do not show good agreement between the two populations as to the maf value obtained.cyp2d6*4tends to be more common among european, whereas cyp2d6*10is more common in malays and chinese among singaporean.Regardless of different phenotype, maf of cyp2d6*4for indians is similar to that seen by the european.Singaporeans show smaller maf for cyp2c19*17but higher cyp2c19*2frequencies as opposed to european ones.Following growing attention to the contribution of cyp3a4/5,n-acetyltransferases (nat2), thiopurine methyltransferase (tpmt) and uridine diphosphate glucuronosyltransferases (ugt)2b7in predicting drug response across europe, there are limited pharmacogenetics (pgx) studies examining the gene-drug interaction among malaysian/singaporean.To better understand the heterogeneity of the drug response, pgx studies for the abovementioned enzymes between ethnics in malaysian/singaporean should be identified.

Journal: Drug metabolism and personalized therapy (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Clinical Characteristics and Outcome Analysis for HLA Loss Patients Following Partially Mismatched Related Donor Transplantation Using HLA Chimerism for Loss of Heterozygosity Analysis by Next-Generation Sequencing.

Genomic loss of mismatched human leukocyte antigen (hla loss) is one of the most vital immune escape mechanisms of leukemic cells after allogeneic hematopoietic stem cell transplantation (allo-hsct).However, the methods currently used for hla loss analysis have some shortcomings.Limited literature has been published, especially in lymphoid malignancies.This study aims to evaluate the incidences, risk factors of hla loss, and clinical outcomes of hla loss patients.In all, 160 patients undergoing partially mismatched related donor (mmrd) transplantation from 18 centers in china were selected for hla loss analysis with the next-generation sequencing (ngs)-based method, which was validated by hla-kmr.Variables of the prognostic risk factors for hla loss or hla loss-related relapse were identified with the logistic regression or the fine and gray regression model.An hla loss detection system, hla-cln [hla chimerism for loss of heterozygosity (loh) analysis by ngs], was successfully developed.Forty (25.0%) patients with hla loss were reported, including 27 with myeloid and 13 with lymphoid malignancies.Surprisingly, 6 of those 40 patients did not relapse.The 2-year cumulative incidences of hla loss (22.7% vs 22.0%,p= 0.731) and hla loss-related relapse (18.4% vs 20.0%,p= 0.616) were similar between patients with myeloid and lymphoid malignancies.The number of hla mismatches (5/10 vs <5/10) was significantly associated with hla loss in the whole cohort [odds ratio (or): 3.15,p= 0.021] and patients with myeloid malignancies (or: 3.94,p= 0.021).A higher refined-disease risk index (or: 6.91,p= 0.033) and donor-recipient abo incompatibility (or: 4.58,p= 0.057) contributed to hla loss in lymphoid malignancies.To sum up, hla-cln could overcome the limitations of hla-kmr and achieve a better hla coverage for more patients.The clinical characteristics and outcomes were similar in patients with hla loss between myeloid and lymphoid malignancies.In addition, the results suggested that a patient with hla loss might not always relapse.

Journal: Cell transplantation (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Development and validation of a risk score for chest pain with suspected non-ST-segment elevation acute coronary syndrome.

To investigate a new risk score for acute chest pain with suspected non-st-segment elevation acute coronary syndrome (nste-acs).Methods patients who suffered from chest pain and suspected nste-acs were enrolled as subjects.Predictor variables had been analyzed, and a bootstrap technique was used to evaluate the internal validity of the model, and external validation had been assessed for a prospective cohort study.Results thousand five hundred and sixty-eight patients had been included in this study.Six predictor variables were found to be significant and were used to develop the model.The c-statistic of the model was 0.83, and internal validation revealed the stability of the model and the absence of over-optimism.Patients were given different triage recommendations, and the risk score was prospectively validated.Conclusions a risk score may be a suitable method for assessing the risk of major adverse cardiac events and aiding patient triage in emergency departments among patients with suspected nste-acs.

Journal: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc (2022)
Publication types: Journal Article