syedzayyan/paper_mill_benchmark huggingface dataset:
Penetration Enhancement Strategies for Intradermal Delivery of Cromolyn Sodium.

This study aimed to explore the use of chemical and physical enhancement strategies for the intradermal delivery of cromolyn sodium (cs) for treatment of atopic dermatitis.Cs gels were formulated to individually contain 2.5 and 9% salcaprozate sodium (snac) as a potential chemical enhancer.The effect of microneedles, alone and in combination with snac, was investigated via in vitro permeation studies.Skin impedance and ftir evaluation of snac-treated stratum corneum (sc) was done and compared to the control.The amount of drug delivered in the dermis after 24 h by the 2.5% and 9% snac gels was 23.29 ± 1.89 μg/cm2and 35.87 ± 2.23 μg/cm2, respectively, which were significantly higher than the control (p 0.05).Microneedles enhanced permeation in both the control and 2.5% snac groups (p 0.05).Over 24 h of treating the sc with 2.5% snac, ftir evaluation showed stretches on the ch2asymmetric and symmetric stretching vibrations observed at 2920.23 cm-1and 2850.79 cm-1respectively in untreated sc, which shifted to higher wavenumbers and indicated some lipid fluidizing effect.However, no significant drop in skin impedance was seen with snac as compared to the control (p > 0.05).Snac was concluded to have skin permeation enhancement effect on cs, while microneedles effectively enhanced cs permeation even in the absence of snac.

Journal: AAPS PharmSciTech (2022)
Publication types: Journal Article
Helicobacter pylori: An Underrated Cause of Immune Thrombocytopenic Purpura. A Comprehensive Review.

Idiopathic thrombocytopenic purpura (itp) is the autoimmune-mediated destruction of platelets.Itp is a diagnosis of exclusion after other identifiable etiologies have been ruled out.After the first report by gasbarrini et al.(1998) showing rising platelet counts in itp patients following helicobacter pylori(hp) eradication therapy, there is growing evidence that highlights the role of hp in triggering itp.However, the exact pathophysiology of hp-associated itp is still unclear, but many theories have been implicated in this regard.According to various reports, the postulated mechanisms for the role of hp in c itp include molecular mimicry, increased plasmacytoid dendritic cell numbers, phagocytic perturbation, and variable host immune response to hp virulence factors.One famous theory suggested molecular mimicry between platelet surface antigen and bacterial virulence factor, i.e.Cytotoxin-associated gene a (cag a).It is thought that a chronic inflammatory response following an hp infection induces the host autoantibodies' response against cag a, which cross-reacts with platelet surface glycoproteins; therefore, it may accelerate platelet destruction in the host reticuloendothelial system.However, further studies are mandated to better understand the causal link between itp and hp and study the role of biogeography.Nowadays, it is recommended that every patient with itp should undergo hp diagnostic testing and triple therapy should be administered in all those candidates who test positive for hp infection.In our review, there were a few pregnant female itp patients who took hp eradication therapy mainly after 20 weeks of gestation without maternal or fetal worst outcomes.However, large-scale studies are advisable to study the adverse fetal outcomes following triple therapy use.

Journal: Cureus (2019)
Publication types: Journal Article;Review
Hepatocyte-targeting and tumor microenvironment-responsive liposomes for enhanced anti-hepatocarcinoma efficacy.

To increase the antitumor drug concentration in the liver tumor site and improve the therapeutic effects, a functionalized liposome (ppp-lip) with tumor targetability and enhanced internalization after matrix metalloproteinase-2 (mmp2)-triggered cell-penetrating peptide (tatp) exposure was modified with myrcludex b (a synthetic hbv pre s-derived lipopeptide endowed with compelling liver tropism) for liver tumor-specific delivery.After intravenous administration, ppp-lip was mediated by myrcludex b to reach the hepatocyte surface.The mmp2-overexpressing tumor microenvironment deprotected peg, exposing it to tatp, facilitating tumor penetration and subsequent efficient destruction of tumor cells.In live imaging of small animals and cellular uptake, ppp-lip was taken up much more than typical unmodified liposomes in the icr mouse liver and liver tumor cells.Hydroxycamptothecin (hcpt)-loaded ppp-lip showed a better antitumor effect than commercially available hcpt injections among mtt, three-dimensional (3 d) tumor ball, and tumor-bearing nude mouse experiments.Our findings indicated that ppp-lip nanocarriers could be a promising tumor-targeted medication delivery strategy for treating liver cancers with elevated mmp2 expression.

Journal: Drug delivery (2022)
Publication types: Journal Article
Green rebranding: Regenerative agriculture, future-pasts, and the naturalisation of livestock.

Anxieties around the relationship between livestock agriculture and the environmental crisis are driving sustained discussions about the place of beef and dairy farming in a sustainable food system.Proposed solutions range from 'clean-cow' sustainable intensification to 'no-cow', animal free futures, both of which encourage a disruptive break with past practice.This paper reviews the alternative proposition of regenerative agriculture that naturalises beef and dairy production by invoking the past to justify future, nature-based solutions.Drawing on fieldwork in the uk, it first introduces two of the most prominent strands to this green rebranding of cattle: the naturalisation of ruminant methane emissions and the optimisation of soil carbon sequestration via the use of ruminant grazing animals.Subsequent thematic analysis outlines the three political strategies of post-pastoral storytelling, political ecological baselining and a probiotic model of bovine biopolitics that perform this naturalisation.The conclusion assesses the potential and the risks of this approach to grounding the geographies and the temporalities of agricultural transition in the anthropocene: an epoch in which time is out of joint and natures are multiple and non-analogue, such that they provide slippery and contested grounds for political solutions.

Journal: Transactions (Institute of British Geographers : 1965) (2022)
Publication types: Journal Article
The experience of participating in an internet-based cognitive behavioral therapy program among patients with cardiovascular disease and depression: a qualitative interview study.

Depression in conjunction with cardiovascular disease (cvd) is associated with worsening in cvd, higher mortality, and poorer quality of life.Despite the poor outcomes there is a treatment gap of depression in cvd patients.Recently we found that an internet-based cognitive behavioral therapy (i cbt) tailored for cvd patients led to reduced symptoms of depression.However, we still have little knowledge about cvd patients' experiences of working with i cbt.The aim of this study was therefore to explore cvd patients' experiences of engaging in a tailored i cbt program.Methods a qualitative interview study using inductive thematic analysis.Data was obtained from 20 patients with cvd and depressive symptoms who had participated in a randomized controlled trial (rct) evaluating the impact of a nine-week i cbt program on depression.Results three main themes emerged: (1) taking control of the disease, (2) not just a walk in the park, and (3) feeling a personal engagement with the i cbt program.The first theme included comments that the tailored program gave the patients a feeling of being active in the treatment process and helped them achieve changes in thoughts and behaviors necessary to take control of their cvd.The second theme showed that patients also experienced the program as demanding and emotionally challenging.However, it was viewed as helpful to challenge negative thinking about living with cvd and to change depressive thoughts.In the third theme patients reported that the structure inherent in the program, in the form of organizing their own health and the scheduled feedback from the therapist created a feeling of being seen as an individual.The feeling of being acknowledged as a person also made it easier to continuously work with the changes necessary to improve their health.Conclusions engaging in an i cbt program tailored for patients with cvd and depression was by the patients perceived as helpful in the treatment of depression.They experienced positive changes in emotions, thoughts, and behaviors which a result of learning to take control of their cvd, being confirmed and getting support.The patients considered working with the i cbt program as demanding and emotionally challenging, but necessary to achieve changes in emotions, thoughts, and behaviors.

Journal: BMC psychiatry (2022)
Publication types: Journal Article;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
All in for patient safety: a team approach to quality improvement in our laboratories.

Patient safety and quality improvement initiatives are integral parts of every cytopathology laboratory.The need to revisit our approaches to patient safety are essential in light of the expanding test menu, ancillary studies, comprehensive diagnostic reports, and emergence of new technologies for augmenting cytologic diagnosis.Our interview with drs.Yael heher, adam seegmiller, and paul vander laan explores recent developments that have shaped their perspectives in patient safety, test usage, and laboratory quality.The practical strategies presented provide tools for enhanced patient safety and improved outcomes in a new era of ancillary and molecular testing and standardized reporting in the cytopathology laboratory.

Journal: Journal of the American Society of Cytopathology (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Review
A new species ofDiaphorocerafrom Morocco with unclear relationships and a key to the species (Coleoptera, Meloidae, Cerocomini).

Diaphorocera neglectasp.N.from morocco is described.Photos of the new species are provided and male features are figured.The new species has intermediate characters between the groups of d.Hemprichiand d.Promelaenaas defined in the literature.These groups are discussed and a new key to the species is presented.

Journal: ZooKeys (2018)
Publication types: Journal Article
COVID-19 Vaccine Uptake Among Patients With Systemic Lupus Erythematosus in the American Midwest: The Lupus Midwest Network (LUMEN).

Patients with systemic lupus erythematosus (sle) are at higher risk of poor outcomes from coronavirus disease 2019 (covid-19).The vaccination rate among such patients is unknown.We aimed to assess covid-19 vaccine uptake among patients with sle.Methods we included 342 patients with sle from the lupus midwest network (lumen) and 350 age-, sex-, race-, and county-matched comparators.Vaccination uptake for influenza, pneumococcal, and zoster vaccines before pandemic restrictions began (up to february 29, 2020) was assessed.First-dose covid-19 vaccine uptake was electronically retrieved and manually ascertained (december 15, 2020, to july 31, 2021).Time to covid-19 vaccination, demographics, sle manifestations, medications, charlson comorbidity index, area deprivation index, and rural-urban commuting area codes were compared.Results on july 31, 2021, 83.3% of patients with sle and 85.5% of comparators were vaccinated against covid-19.The covid-19 vaccination rates were similar among sle and comparators (hazard ratio 0.93, 95% ci 0.79-1.10).Unvaccinated patients with sle were more likely than vaccinated patients to be men (27.3% vs 14.1%), younger (mean age 54.1 vs 58.8 yrs), have a shorter sle duration (median 7.3 vs 10.7 yrs), and be less frequently vaccinated with influenza and pneumococcal vaccines.Conclusion patients with sle in the lupus midwest network had similar covid-19 vaccination uptake as matched comparators, most of whom were vaccinated early when the vaccine became available.One in 6 patients with sle remain unvaccinated.

Journal: The Journal of rheumatology (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, U.S. Gov't, P.H.S.
Tumor microenvironment-responsive versatile "Trojan horse" theranostic nanoplatform for magnetic resonance imaging-guided multimodal synergistic antitumor treatment.

A natural killer (nk)-92 cell membrane-camouflaged mesoporous mn o2-enveloped au@pd (au@pd@mn o2) nanoparticles (denoted as apmn nps)-based versatile biomimetic theranostic nanoplatform was developed for magnetic resonance (mr) imaging-guided multimodal synergistic antitumor treatments.In this core-shell nanostructure, an au@pd core induced near-infrared (nir)-activatable hyperthermal effects and nanozyme catalytic activity, while a mesoporous mn o2shell not only afforded a high drug-loading capability, tumor microenvironment (tme)-triggered mr imaging and drug release, but also endowed catalase-, glutathione peroxidase-, and fenton-like activities.Furthermore, the nk-92 cell membrane camouflaging endowed the nps with enhanced tumor-targeting capability, immune escape function, and membrane protein-mediated tumoral uptake property.The doxorubicin-loaded apmn (d-apmn) nps exhibited tme-responsive drug release properties.Furthermore, the cellular uptake, in vivo mr imaging, and nir thermal imaging confirmed the active tumor-targeting capability and tme-responsive mr imaging property of these biomimetic nps.An antitumor efficacy test, histological analyses, and blood biochemical profiles suggested that the developed d-apmn nps possessed a high antitumor activity and biosafety in tumor-bearing nude mice.Therefore, the developed apmn nps held great potential as an intelligent and comprehensive theranostic nanoplatform for tumor-specific bioimaging and tme-responsive multimodality treatment based on photothermal therapy, chemodynamic therapy, and chemotherapy.Statement of significance: exploring intelligent and comprehensive theranostic nanoplatforms to integrate tumor-specific bioimaging and tme-responsive multimodal therapy effectively is a challenge.Herein, we successfully developed a new kind of nk-92 cell membrane-camouflaged mesoporous mn o2-enveloped au@pd nanoparticles (apmn nps)-based versatile biomimetic theranostic nanoplatform for the potential mr imaging-guided multimodal synergistic antitumor treatments.These nps could integrate unique structural, optical, multiple-catalytic, paramagnetic, and biological merits of nk-92 cell membrane, au@pd cores and mesoporous mn o2shell in a single nanoplatform.The nk-92 cell membrane camouflaging endowed the nps with enhanced tumor-targeting capability, immune escape function, and membrane protein-mediated tumoral uptake property.The new information obtained from this study may be beneficial to promote the development of novel tme-responsive versatile "trojan horse" theranostic nanoplatforms for efficient mr imaging-guided multimodal synergistic treatment.

Journal: Acta biomaterialia (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
An overview of therapeutic potential of N-alkylated 1-deoxynojirimycin congeners.

Polyhydroxylated alkaloids display a wide range of biological activities, suggesting their use in the treatment of various diseases.Their most famous representative, 1-deoxynojirimycin (dnj), is a natural product that shows α- and β-glucosidase inhibition.This molecule has been since converted into two clinically approved drugs i.e., zavesca® and glyset®, targeting type i gaucher's disease and type ii diabetes mellitus, respectively.This review examines the therapeutic potential of important dnj congeners reported in last decade and presents concise mechanism of glycosidase inhibition.A brief overview of substituents conjugation's impact on dnj scaffold (including n-alkylated dnj derivatives, mono-valent, di-valent and multivalent dnj congeners, n-[5-(adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin (amp-dnm) look alike dnj based lipophilic derivatives, amp-dnm based neoglycoconjugates, dnj click derivatives with varying carboxylic acids and aromatic moieties, conjugates of dnj and glucose, and n-bridged dnj analogues) towards various enzymes such as α/β glucosidase, porcine trehalase, as f508del-cftr correctors, α-mannosidase, human placental β-glucocerebrosidase, n370s β-gcase, α-amylase and insect trehalase as potent and selective inhibitors have been discussed with potential bioactivities, which can provide inspiration for future studies.

Journal: Carbohydrate research (2021)
Publication types: Journal Article;Review
Patient Decision-Making Factors in Aggressive Treatment of Low-Risk Prostate Cancer.

Active surveillance (as) is underutilized for low-risk prostate cancer.This study examines decision-making factors associated with as vs aggressive treatment in a population-based cohort of low-risk patients.Methods newly diagnosed patients (n = 599) were enrolled through the north carolina central cancer registry from 2011 to 2013 and surveyed regarding 5 factors that may impact treatment decision making: perceived cancer aggressiveness, aggressiveness of treatment intent, most important goal (eg, cure, quality of life), primary information source, and primary decision maker.We examined the association between treatment decision-making factors with patient choice for as vs aggressive treatment using multivariable logistic regression analysis.Results this is a sociodemographically diverse cohort reflective of the population-based design, with 37.6% overall (47.6% among very low-risk patients) choosing as.Aggressive treatment intent (odds ratio [or] = 7.09, 95% confidence interval [ci] = 4.57 to 11.01), perceived cancer aggressiveness (or = 4.93, 95% ci = 2.71 to 8.97), most important goal (cure vs other, or = 1.72, 95% ci = 1.12 to 2.63), and primary information source (personal and family vs physician, or = 1.76, 95% ci = 1.10 to 2.82) were associated with aggressive treatment.Overall, 88.4% of patients (92.2% among very low-risk) who indicated an intent to treat the cancer "not very aggressively" chose as.Conclusions these data from the patient's perspective shed new light on potentially modifiable factors that can help further increase as uptake among low-risk patients.Helping more low-risk patients feel comfortable with a "not very aggressive" treatment approach may be especially important, which can be facilitated through patient education interventions to improve the understanding of the cancer diagnosis and as having a curative intent.

Journal: JNCI cancer spectrum (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Obesity paradox in cardiovascular disease: where do we stand?

Obesity is associated with an increased risk of developing cardiovascular disease (cvd), particularly heart failure (hf) and coronary heart disease (chd).The mechanisms through which obesity increases cvd risk involve changes in body composition that can affect hemodynamics and alters heart structure.Pro-inflammatory cytokines produced by the adipose tissue itself which can induce cardiac dysfunction and can promote the formation of atherosclerotic plaques.When obesity and hf or chd coexist, individuals with class i obesity present a more favorable prognosis compared to individuals who are normal or underweight.This phenomenon has been termed the "obesity paradox." obesity is defined as an excess fat mass (fm), but individuals with obesity typically also present with an increased amount of lean mass (lm).The increase in lm may explain part of the obesity paradox as it is associated with improved cardiorespiratory fitness (crf), a major determinant of clinical outcomes in the general population, but particularly in those with cvd, including hf.While increased lm is a stronger prognosticator in hf compared to fm, in patients with chd excess fm can exert protective effects particularly when not associated with increased systemic inflammation.In the present review, we discuss the mechanisms through which obesity may increase the risk for cvd, and how it may exert protective effects in the setting of established cvd, with a focus on body composition.We also highlight the importance of measuring or estimating crf, including body composition-adjusted measures of crf (ie, lean peak oxygen consumption) for an improved risk status stratification in patients with cvd and finally, we discuss the potential non-pharmacologic therapeutics, such as exercise training and dietary interventions, aimed at improving crf and perhaps clinical outcomes.

Journal: Vascular health and risk management (2019)
Publication types: Journal Article;Review
Acoustic Emission Source Location Using Finite Element Generated Delta-T Mapping.

One of the most significant benefits of acoustic emission (ae) testing over other non-destructive evaluation (nde) techniques lies in its damage location capability over a wide area.The delta-t mapping technique developed by researchers has been shown to enable ae source location to a high level of accuracy in complex structures.However, the time-consuming and laborious data training process of the delta-t mapping technique has prevented this technique from large-scale application on large complex structures.In order to solve this problem, a finite element (fe) method was applied to model training data for localization of experimental ae events on a complex plate.Firstly, the fe model was validated through demonstrating consistency between simulated data and the experimental data in the study of hsu-nielsen (h-n) sources on a simple plate.Then, the fe model with the same parameters was applied to a planar location problem on a complex plate.It has been demonstrated that fe generated delta-t mapping data can achieve a reasonable degree of source location accuracy with an average error of 3.88 mm whilst decreasing the time and effort required for manually collecting and processing the training data.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article
Association between sleep characteristics, ideal cardiovascular health, and systemic inflammation, NHANES 2017-2018.

There is conflicting evidence regarding the associations between sleep deprivation and inflammatory biomarkers indicative of cardiovascular disease risk, such as high-sensitivity c-reactive protein (hs crp).The association between sleep habits and hs crp was quantified in a nationally representative sample of adults in the united states and mediation by ideal cardiovascular health metrics was explored.A cross-sectional analysis of cardiovascular disease-free participants aged 20-79 years from the 2017-2018 national health and nutrition examination survey was conducted.The primary exposures were self-reported sleep duration, sleep debt (difference between the average weekday and weekend sleep duration), and ideal cardiovascular health (11-14 points).The primary outcome was hs crp (high-risk ≥ 3.0 mg/l).Multivariable robust poisson models were used to estimate prevalence ratios after multiple imputation.A subgroup analysis of shift workers was also conducted.Of 4027 participants included (mean age 46 years; 52% female; 41% shift workers), the prevalence of sleeping <6 h on weekdays was 9%, with 40% sleeping ≥9 h on weekends.One-quarter had a high (≥2 h) sleep debt, 82% had poor cardiovascular health, and 34% had high-risk hs crp.There were no significant associations between weekday sleep duration or sleep debt with high-risk hs crp, even among shift workers.Mediation analysis was not conducted.Ideal cardiovascular health was associated with a lower prevalence of high-risk hs crp (prevalence ratios, 0.60, 95% ci, 0.48-0.75).The lack of significant associations suggests a complex interrelationship of hs crp with factors beyond sleep duration.Examination of populations at highest risk of chronic sleep deprivation could help to elucidate the association with systemic inflammation-related outcomes.

Journal: Journal of sleep research (2022)
Publication types: Journal Article