syedzayyan/paper_mill_benchmark huggingface dataset:
Psychopathological and Neurobiological Overlap Between Anorexia Nervosa and Self-Injurious Behavior: A Narrative Review and Conceptual Hypotheses.

Empirical evidence and clinical observations suggest a strong -yet under acknowledged-link between anorexia nervosa (an) and non-suicidal self-injurious behavior (nssi).By reviewing the literature on the psychopathology and neurobiology of an and nssi, we shed light on their relationship.Both an and nssi are characterized by disturbances in affect regulation, dysregulation of the reward circuitry and the opioid system.By formulating a reward-centered hypothesis, we explain the overlap between an and nssi.We propose three approaches understanding the relationship between an and nssi, which integrate psychopathology and neurobiology from the perspective of self-destructiveness: (1) a nosographical approach, (2) a research domain (rdo c) approach and (3) a network analysis approach.These approaches will enhance our knowledge of the underlying neurobiological substrates and may provide groundwork for the development of new treatment options for disorders of self-destructiveness, like an and nssi.In conclusion, we hypothesize that self-destructiveness is a new, dsm-5-transcending concept or psychopathological entity that is reward-driven, and that both an and nssi could be conceptualized as disorders of self-destructiveness.

Journal: Frontiers in psychiatry (2022)
Publication types: Journal Article
RSC AdvancesOutstanding Student Paper Awards 2021.

In 2021,rsc advanceslaunched an award series to recognise the hard work of students.These awards recognise outstanding work published in the journal, for which a substantial component of the research was conducted by a student.

Journal: RSC advances (2022)
Publication types: Editorial
New Ln-MOFs based on mixed organic ligands: synthesis, structure and efficient luminescence sensing of the Hg2+ions in aqueous solutions.

In view of hg2+ion sensing by luminescence, a series of new, phenanthroline-decorated 3d lanthanide metal organic frameworks (ln-mofs) valorising an original combination of four different lanthanides and two organic ligands,i.e.thiobis(4-methylene-benzoic acid) (h2tmba) and 1,10-phenanthroline (phen), have been successfully synthesized, namely {[ln4(tmba)6(phen)4]·m(h2o)(phen)}n[ln = ce,m= 3 (1); pr,m= 1 (2); eu,m= 3 (3); and tb,m= 3 (4)].Compounds 1-4 were characterised by single-crystal x-ray diffraction, elemental and thermogravimetric analyses, and powder x-ray diffraction.The luminescence properties of complexes 3 and 4 were thoroughly investigated.It is herein proved that compound 3 sensitively and selectively acts as an excellent luminescent probe for the detection of hg2+ions in waters, with a detection limit of 1.00 μm.As additional assets, 3 displays superb stability over a wide p h range (3-12) of the aqueous media, as well as convenient recycling after completion of the detection experiments.The rationale for the observed luminescence quenching effect of mercury might be a strong interaction arising between hg2+ions and the carboxylate oxygen atoms of the tmba2-ligand.The results open new perspectives for applications in environmental remediation.

Journal: Dalton transactions (Cambridge, England : 2003) (2021)
Publication types: Journal Article
Peripheral pulmonary mucous gland adenoma with a cavity mimicking lung cancer.

A 71-year-old woman presented to our hospital because of a 10 mm nodule with a cavity in right lower lobe on chest computed tomography.Fluorodeoxyglucose-positron emission tomography showed slight accumulation in the nodule (maximum standard uptake value 2.08).Her serum carcinoembryonic antigen concentration was 5.4 ng/m l.Wedge resection of the tumor was performed for diagnostic and treatment purposes.Findings on intraoperative pathological examination of a frozen section were suspicious for adenocarcinoma.We, therefore, performed a right lower lobectomy and mediastinal lymph node dissection.Postoperative histological examination revealed a mucous gland adenoma.The patient's postoperative course was favorable and she was discharged 7 days after surgery.Four months later, the serum carcinoembryonic antigen concentration had decreased to 3.1 ng/m l.Pulmonary mucous gland adenomas are rarely located peripherally.These benign tumors should be considered, even in the presence of high serum carcinoembryonic antigen concentrations or increased fluorodeoxyglucose uptake on fluorodeoxyglucose-positron emission tomography.

Journal: General thoracic and cardiovascular surgery (2022)
Publication types: Case Reports;Journal Article
Estimated Cardiorespiratory Fitness Is Associated With Reported Depression in College Students.

Depression is a serious but treatable health issue that affects college students at an alarming rate.Improved cardiorespiratory fitness (crf) decreases depression risk and severity but this relationship has not been fully evaluated in the college student population.Non-exercise estimated crf (e crf) could be used to identify students at risk for or suffering from depression.This study investigated the associations of depression and e crf in college students.Participants (n= 437) completed a survey which included demographic and student-status questions, e crf variables, and a validated depression instrument.Descriptive, chi-square,t-test, regression, and odds ratio analyses were employed.Depression was associated with low-fitness (x2= 4.660,p= 0.031) and e crf below age-predicted crf (t= 3.28,p< 0.001).Predictors of increased depression included low-fitness, sexual orientation, current depression treatment, and gpa (r2= 0.145-0.159; adj r2= 0.135-0.149).Odd ratio analyses determined that low-fitness increased the risk of reporting depression (β = 2.39,p= 0.017, 95% ci = 1.17-4.872) which remained significant when adjusted (β = 2.478,p= 0.017, 95% ci = 1.175-5.229).Adjusted odds ratio analyses also indicated increased risk of reporting depression for those in a sexual minority (β = 2.582,p= 0.001, 95% ci = 1.44,4.629) and undergoing current depression treatment (β = 2.393,p< 0.001, 95% ci = 2.393-13.043).High levels of fitness did not reduce the odds of reporting depression compared to age predicted crf.A simple e crf algorithm can be used to identify college student depression.

Journal: Frontiers in physiology (2019)
Publication types: Journal Article
Food availability and food access in rural agricultural communities: use of mixed methods.

Hispanics bear some of the highest burden of the obesity epidemic and the disparities gap is bigger among hispanics in rural communities.This mixed methods study examined the objective and subjective assessment of food availability and food access in four rural, agricultural, and predominantly hispanic communities.Methods in this convergent parallel mixed methods study, we used the nutrition environment measures survey (nems) of food stores and restaurants to objectively assess 57 food stores and 69 restaurants in four rural agricultural communities in washington state.To complement the objective assessment findings, we conducted semi-structured interviews with 32 community residents.The data were collected from 2013 to 2014.Frequencies and means were calculated for quantitative data and content analysis conducted for interview data.Results participants (n = 32) had a mean age of 35.6 (sd 6.2) years, were mostly women, uninsured, low income, and had less than a high school education.Grocery and convenience stores had low nems composite scores indicating low overall availability of food items, low quality, and high food prices.Composite scores for sit-down restaurants, fast casual restaurants, and fast-food restaurants were similarly low in all four towns indicating limited availability of healthier options.Semi-structured interviews revealed participants perceived high availability and accessibility of quality fresh produce.Most participants reported eating out regularly several times a week, frequenting restaurant chains that serve buffets or fast foods, and allowing children to make decisions regarding their own food choices.Conclusions community members' perception of food availability and food access may be different from the objective assessment of food environment.This information can be used to inform community-wide interventions to address food environment in these rural communities.

Journal: BMC public health (2018)
Publication types: Journal Article
Implementation evaluation of a stepped approach to home care assessment using interRAI systems in Ontario, Canada.

In ontario, new home care clients are screened with the inter rai contact assessment and only those expected to require longer-term services receive the comprehensive rai-home care assessment.Although ontario adopted this two-step approach in 2010, it is unknown whether the assessment guidelines were implemented as intended.To evaluate implementation fidelity, the purpose of this study is to compare expected to actual client profiles and care co-ordinator practice patterns.We linked inter rai ca and rai-hc assessments and home care referrals and services data for a retrospective cohort of adult home care clients admitted in fy 2016/17.All assessments were done by trained health professionals as part of routine practice.Descriptive analyses were used to evaluate congruency between recommended and actual practice.Adjusted cause-specific hazards and logistic approaches were used to examine time to rai-hc assessment and being a high-priority client.Of 225,989 unique home care clients admitted to the publicly funded home care program, about three-quarters of clients were assessed with the inter rai ca only (27.9% completed the preliminary screener only and 46.6% completed both the preliminary screener and clinical evaluation).There was substantial agreement between the skip logic and completion of the clinical evaluation section (cohen's kappa = 0.67 [95% ci: 0.66-0.67]).One-quarter of clients were assessed with both the inter rai ca and rai-hc.As expected, rai-hc assessed clients were older, reported more health needs, and often received home care services for >6 months.Clients in higher assessment urgency algorithm (aua) levels were significantly more likely to receive a rai-hc assessment and be assigned to a higher home care priority level; however, 28.3% of clients in the highest aua level did not receive a rai-hc assessment.We conclude that the use of the inter rai ca and rai-hc balances the investment of time and resources with the information and tools to deliver high-quality, holistic, and client-centred care.The inter rai ca guides the care co-ordinator to screen every client for a broad range of possible needs and tailor further assessment to each client's unique needs.We recommend integrating the aua into provincial assessment guidelines as well as developing a new quality indicator focused on measuring access to the home care system.

Journal: Health & social care in the community (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
B-cell receptors of EBV-negative Burkitt lymphoma bind modified isoforms of autoantigens.

Burkitt lymphoma (bl) represents the most aggressive b-cell-lymphoma.Beside the hallmark of ig-myc-translocation, surface b-cell receptor (bcr) is expressed, and mutations in the bcr pathway are frequent.Coincidental infections in endemic bl, and specific extra-nodal sites suggest antigenic triggers.To explore this hypothesis, bcrs of bl cell lines and cases were screened for reactivities against a panel of bacterial lysates, lysates of plasmodium falciparum, a custom-made virome array and against self-antigens, including post-translationally modified antigens.An atypically modified, sumoylated isoform of bystin, that is, sumo1-bysl was identified as the antigen of the bcr of cell line ca46.Sumo1-bysl was exclusively expressed in ca46 cells with k139 as site of the sumoylation.Secondly, an atypically acetylated isoform of hsp40 was identified as the antigen of the bcr of cell line bl41.K104 and k179 were the sites of immunogenic acetylation, and the acetylated hsp40 isoform was solely present in bl41 cells.Functionally, addition of sumo1-bysl and acetylated hsp40 induced bcr pathway activation in ca46 and bl41 cells, respectively.Accordingly, sumo1-bysl-eta' immunotoxin, produced by a two-step intein-based conjugation, led to the specific killing of ca46 cells.Autoantibodies directed against sumo1-bysl were found in 3 of 14 (21.4%), and autoantibodies against acetylated hsp40 in 1/14(7.1%) patients with sporadic burkitt-lymphoma.No reactivities against antigens of the infectious agent spectrum could be observed.These results indicate a pathogenic role of autoreactivity evoked by immunogenic post-translational modifications in a subgroup of sporadic bl including two ebv-negative bl cell lines.

Journal: EJHaem (2022)
Publication types: Journal Article
Intrauterine exposure to preeclampsia does not impair vascular health in children.

And objectives preeclampsia is a serious multisystem blood pressure disorder during pregnancy that is associated with increased long-term risk of cardiovascular disease to the mother and offspring.We investigated the vascular health of children exposed to intrauterine preeclampsia.Materials and methods this was a cross-sectional study of offspring in a prospective cohort of women with complications during pregnancy.Children aged between 2 and 5 years [median age 4.7 (2.8, 5.1) years] exposed to intrauterine preeclampsia (n= 26) or normotensive controls (n= 34), were recruited between july 2020 and april 2021.Vascular health was assessed by measuring aortic intima-media thickness and pulse wave velocity.Univariate generalized linear regression models were used to explore associations between vascular measurements and explanatory variables.Results children exposed to preeclampsia had a lower body mass index at assessment (15.5 vs.16.2 kg/m2,p= 0.04), birth weight (2.90 vs.3.34 kg,p= 0.004), gestational age at birth (37.5 vs.39.4 weeks,p< 0.001) and higher frequency of preterm birth (27% vs.6%,p= 0.02).There were no differences in vascular health between children exposed to preeclampsia vs.Controls (mean aortic intima-media thickness 0.575 mm vs.0.563 mm,p= 0.51, pulse wave velocity 4.09 vs.4.18 m/s,p= 0.54) and there were no significant associations in univariate analyses.Conclusions there were no major adverse differences in vascular health which contrasts with existing studies.This suggests exposure to intrauterine preeclampsia may result in a less severe cardiovascular phenotype in young children.While reassuring, longitudinal studies are required to determine if and when exposure to intrauterine preeclampsia affects vascular health in children.

Journal: Frontiers in public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Faculty diversity, equity, and inclusion in academic dentistry: Revisiting the past and analyzing the present to create the future.

In 2021, nidcr published the landmark report "oral health in america." it described that while oral health-related research and care has seen amazing progress, oral health inequities and lack of oral care for large segments of the us population have not improved.This situation plus the predicted increase of the diversification of the us population requires decisive actions to ensure that future dentists will be optimally prepared to provide the best possible care for all patients.A diverse dental educator workforce plays a crucial role in obtaining this goal.The objectives of this document were threefold.Aim 1 was to analyze past and current trends in the diversity and inclusion of historically underrepresented ethnic/racial (hure) and marginalized (hurm) dental faculty members.Aim 2 focused on reviewing best practices and challenges related to achieving dental faculty and leadership diversity and inclusion.Aim 3 was to develop recommendations for increasing the diversity and inclusion of dental faculty in the present and future.Methods an analysis of ethnicity/race and gender faculty data collected by the american dental education association (adea) in 2011-2012 and 2018-2019 showed that achieving faculty diversity and inclusion has been an ongoing challenge, with limited success for faculty from hure backgrounds.In order to create this much-needed change, best practices to increase the applicant pool, change recruitment strategies, and develop solid retention and promotion efforts were described.Research discussing the challenges to creating such changes was analyzed, and strategies for interventions were discussed.Conclusion in conclusion, evaluations of efforts designed to create a more diverse and inclusive work force is crucial.Institutions must evaluate their diversity data, practices utilized, and the policies implemented to determine whether the desired outcomes are achieved.Only then will the future dental workforce be optimally prepared to provide the best possible care for all patients in the united states.

Journal: Journal of dental education (2022)
Publication types: Journal Article
Nanomaterials as a sustainable choice for treating wastewater.

Wastewater containing toxic substances is a major threat to the health of both aquatic and terrestrial ecosystems.In order to treat wastewater, nanomaterials are currently being studied intensively due to their unprecedented properties.The unique features of nanoparticles are prompting an increasing number of studies into their use in wastewater treatment.Although several studies have been undertaken in recent years, most of them did not focus on some of the nanomaterials that are now often utilized for wastewater treatment.It is essential to investigate the most recent advances in all the types of nanomaterials that are now frequently employed for wastewater treatment.The recent advancements in common nanomaterials used for sustainable wastewater treatment is comprehensively reviewed in this paper.This paper also thoroughly assesses unique features, proper utilization, future prospects, and current limitations of green nanotechnology in wastewater treatment.Zero-valent metal and metal oxide nanoparticles, especially iron oxides were shown to be more effective than traditional carbon nanotubes (cnts) for recovering heavy metals in wastewater.Iron oxide achieved 75.9% cod (chemical oxygen demand) removal efficiency while titanium oxide (ti o2) achieved 75.5% cod.Iron nanoparticles attained 72.1% methyl blue removal efficiency.However, since only a few types of nanomaterials have been commercialized, it is important to also focus on the economic feasibility of each nanomaterial.This study found that the large surface area, high reactivity, and strong mechanical properties of nanoparticles means they can be considered as a promising option for successful wastewater treatment.

Journal: Environmental research (2022)
Publication types: Journal Article
A Simple and Reliable Dispersive Liquid-Liquid Microextraction with Smartphone-Based Digital Images for Determination of Carbaryl Residues inAndrographis paniculataHerbal Medicines Using Simple Peroxidase Extract fromSenna siameaLam. Bark.

A simple and reliable dispersive liquid-liquid microextraction (dllme) coupled with smartphone-based digital images using crude peroxidase extracts from cassia bark (senna siamea lam.) was proposed to determine carbaryl residues in andrographis paniculataherbal medicines.The method was based on the reaction of 1-naphthol (hydrolysis of carbaryl) with 4-aminoantipyrine (4-ap) in the presence of hydrogen peroxide, using peroxidase enzyme simple extracts from cassia bark as biocatalysts under p h 6.0.The red product, after preconcentration by dllme using dichloromethane as extraction solvent, was measured for blue intensity by daily life smartphone-based digital image analysis.Under optimized conditions, good linearity of the calibration graph was found at 0.10-0.50 mg·l-1(r2= 0.9932).Limits of detection (lod) (3sd/slope) and quantification (loq) (10sd/slope) were 0.03 and 0.09 mg·l-1, respectively, with a precision of less than 5%.Accuracy of the proposed method as percentage recovery gave satisfactory results.The proposed method was successfully applied to analyze carbaryl in andrographis paniculataherbal medicines.Results agreed well with values obtained from the hplc-uv method at 95% confidence level.This was simple, convenient, reliable, cost-effective and traceable as an alternative method for the determination of carbaryl.

Journal: Molecules (Basel, Switzerland) (2022)
Publication types: Journal Article
National surveys to evaluate prescribing practices: Methodological considerations.

With the changing healthcare landscape, evaluating the care provision in ambulatory settings is vital to understand outpatient care.The national surveys such as the national ambulatory medical care survey (namcs) and the national hospital ambulatory medical care survey (nhamcs) are valuable resources to pharmacy researchers because of their availability and generalizability.With the recent focus on real-world data, the national surveys are critical in providing practice and policy evidence by evaluating ambulatory care, especially prescribing practices.The use of these surveys requires an understanding of the survey content, scope, complex sampling scheme, and analytical and research considerations.There are several methodological and practical considerations that make these national surveys useful to both novice and seasoned researchers.Although some generalized approaches are available for analyzing the national surveys, there is limited focus on the namcs and the nhamcs.This paper provides an in-depth understanding of the namcs/nhamcs, including methodological considerations for evaluating prescribing practices in ambulatory settings.

Journal: Research in social & administrative pharmacy : RSAP (2022)
Publication types: Journal Article
Cerebrospinal Fluid Cultures in Traumatic Brain Injury: Is It Worth It? A Two-Center Study.

Patients with traumatic brain injury (tbi) frequently develop leukocytosis, fever, and tachycardia that may lead to extensive medical investigations to rule out an infectious process.Cerebrospinal fluid (csf) is often acquired during this workup, however, the utility of this practice has not been studied previously.We hypothesized that csf cultures would unlikely yield positive results in patients with tbi.patients and methods:a retrospective review was conducted of all patients with tbi admitted to two level 1 trauma centers at urban, academic institutions from january 2009 to december 2016.Data collected included patient demographics, presenting glasgow coma score (gcs), injury profile, injury severity scores (iss), regional abbreviated injury scale (ais), hospital and intensive care unit (icu) length of stay (los), ventilator days, and culture results.For purposes of the analysis, csf cultures with staphylococcus epidermidis,staphylococcus aureus,or candidaunderwent a chart review and were considered contaminates if indicated.results:there were 145 patients who had csf cultures obtained with a median age of 39 years; 77.2% were male.The majority of patients presented after blunt trauma with median gcs of 6, head ais of 4, and iss of 25.These patients had prolonged median icu and hospital stays at 13 and 22 days, respectively.Six (4.1%) csf cultures demonstrated growth.Four (2.8%) were deemed contaminants, with two growing staphylococcus epidermidisonly,one with both staphylococcus epidermidisand staphylococcus aureus, and one with candida.two cultures (1.4%) were positive and grew enterobacter cloacae.of note, both patients had prior instrumentation with an external ventricular drain.conclusion:obtaining csf cultures in patients with tbi is of low yield, especially in patients without prior external ventricular drain.Other sources of infectious etiologies should be considered in this patient population.

Journal: Surgical infections (2021)
Publication types: Journal Article