syedzayyan/paper_mill_benchmark huggingface dataset:
Socio-environmental conflict over abandoned mining waste in Copaquilla, Chile.

The material discarded by past mining extractive activities is exposed to the action of different environmental agents and constitutes the beginning of a problem that, inevitably, involves the population and the conditions of the environment where it is deposited.Bearing this in mind, a study of the copaquilla-chile valley was carried out with a focus on the socio-environmental conflict produced by the accumulation of abandoned mining waste in its vicinity.The objectives were to identify the role of the different actors and the main causes that originated the conflict and to characterize the physical-natural factors that conditioned the susceptibility and physical vulnerability of the studied environment.The methodological approach combined a set of qualitative and quantitative techniques, using participatory action research techniques (par) and multi-criteria evaluation models (mce) through a geographic information system (gis).The evaluation of the study area revealed quite severe levels in terms of the indices of susceptibility to processes of mass removal and vulnerability of the aquifer, which led us to infer that the morpho-climatic and hydrogeological characteristics of the sector generated the appropriate conditions to produce large damage to the complex socio-ecological system of the copaquilla territory.This study generated participatory material, a chronology of the conflict, a database of the physical environment of the copaquilla valley interpreted in thematic cartographies, and physicochemical soil and water samples to monitor contamination levels.

Journal: Environmental science and pollution research international (2021)
Publication types: Journal Article
Charting the dorsal-medial functional gradient of the default mode network in major depressive disorder.

Major depressive disorder (mdd) is a common and disabling psychiatric condition associated with aberrant functional activity of the default mode network (dmn).However, it is unclear how the dmn dysfunction in mdd patients is characterized by functional connectivity diversity or gradient and whether antidepressant therapy causes the abnormal functional gradient of the dmn to change toward normalization.In current work, we estimated the functional gradient of the dmn derived from resting state functional magnetic resonance imaging in mdd patients (n = 70) and matching healthy controls (n = 43) and identified mdd-related functional connectivity diversity of the dmn.The longitudinal changes of the dmn functional gradient in 36 mdd patients were assessed before and after 12-week antidepressant treatment.Compared to the healthy controls, the functional gradient of the dmn exhibited relatively relative compression along the dorsal-medial axis in mdd patients at baseline and antidepressant treatment could normalize these dmn gradient abnormalities.A regularized least-squares regression model based on dmn gradient features at baseline significantly predicted the change of hamilton depression rating (hamd) scale scores after antidepressant treatment.The medial prefrontal cortex gradient had a more contribution to prediction of antidepressant efficacy.Our findings provided a novel insight into the neurobiological mechanism underlying mdd from the perspective of the dmn functional gradient.

Journal: Journal of psychiatric research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Near-Real-Time Learner Analysis and Faculty Support During a Transition to Online Education.

The teaching tip described here relates to a department level initiative to gather and act on student experiences in real-time during the covid-19 outbreak in the spring 2020 semester.The survey was developed to be an ongoing, department level, data collection source that could capture, triage, and react to student's unique situations as they arose.This enabled us to coordinate across courses, follow-up and provide students and instructors assistance in real time, and also gather information that informed decision making for our summer online courses as well as our planning for the fall.In this teaching tips article we describe the opportunities and processes for using such a survey to identify and capture aspects of the students' lived experience that influences the effectiveness of curricular change.Doing so fills a need, especially when unexpected changes in learning environments are required, to employ concepts of learner analysis to understand and plan educational experiences for students, even when such experiences are in flux or the concepts are used informally.Supplementary information the online version contains supplementary material available at .

Journal: Biomedical engineering education (2021)
Publication types: Journal Article
A Twelve-Hundred-Year Stable Oxygen Isotope Chronology Constructed Using Subfossil Wood from Schwarzensee Lake, Austrian Alps.

This study presents a new stable oxygen isotope chronology, covering the years 800-2000 ad, constructed using modern and subfossil wood derived from trees growing around lake schwarzensee in austria.The climatic signal imparted in the chronology is conditioned mainly by the direct influence of environmental factors on the isotopic signature of source water, which in turn is regulated by evaporation and condensation mechanisms.The second driver of stable oxygen isotope is the physiological response of trees to changing weather conditions, most importantly rates of transpiration.The chronology of stable oxygen isotopes corresponds well with both temperature (r = 0.485; p < 0.05) and total precipitation (r = -0.548; p < 0.05) during the growing season (may-september).This mixed signal results from the fact that the relationship between the content of stable oxygen isotopes and the influence of climate is multifactorial.Moreover, the effect exerted by meteorological conditions on stable isotope ratio changes over time.This is most probably linked to interannual variation in climatic and environmental factors.

Journal: Radiocarbon (2022)
Publication types: Journal Article
Multiomics analysis reveals that hepatocyte nuclear factor 1β regulates axon guidance genes in the developing mouse kidney.

The transcription factor hepatocyte nuclear factor 1β (hnf-1β) is essential for normal development of the kidney and other epithelial organs.In the developing mouse kidney, hnf-1β is required for the differentiation and patterning of immature nephrons and branching morphogenesis of the ureteric bud (ub).Here, we used ch ip-sequencing (ch ip-seq) and rna sequencing (rna-seq) to identify genes that are regulated by hnf-1β in embryonic mouse kidneys.Ch ip-seq revealed that hnf-1β binds to 8284 sites in chromatin from e14.5 mouse kidneys.Comparison with previous atac-seq and histone modification studies showed that hnf-1β binding peaks colocalized with open chromatin and epigenetic marks of transcriptional activation (h3k27 acetylation, h3k4 trimethylation, h3k4 monomethylation), indicating that the binding sites were functional.To investigate the relationship between hnf-1β binding and hnf-1β-dependent gene regulation, rna-seq was performed on ub cells purified from wild-type and hnf-1β mutant embryonic kidneys.A total of 1632 genes showed reduced expression in hnf-1β-deficient ub cells, and 485 genes contained nearby hnf-1β binding sites indicating that they were directly activated by hnf-1β.Conversely, hnf-1β directly repressed the expression of 526 genes in the ub.Comparison with sn atac-seq analysis of ub-derived cells showed that both hnf-1β-dependent activation and repression correlated with chromatin accessibility.Pathway analysis revealed that hnf-1β binds near 68 axon guidance genes in the developing kidney.Rna-seq analysis showed that nrp1, sema3c, sema3d, sema6a, and slit2 were activated by hnf-1β, whereas efna1, epha3, epha4, epha7, ntn4, plxna2, sema3a, sema4b, slit3, srgap1, unc5c and unc5d were repressed by hnf-1β.Rnascope in situ hybridization showed that nrp1, sema3c, sema3d, sema6a, and slit2 were expressed in wild-type ub and were dysregulated in hnf-1β mutant ub.These studies show that hnf-1β directly regulates the expression of multiple axon guidance genes in the developing mouse kidney.Dysregulation of axon guidance genes may underlie kidney defects in hnf-1β mutant mice.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Essential services: Quantifying the contributions of America's pharmacists in COVID-19 clinical interventions.

As the covid-19 pandemic spread across the united states, america's pharmacists and their teammates expanded their clinical services to help their communities from every practice setting: community and ambulatory care, inpatient, long-term care, academia, public health, and many others.Objectives the objective of the study is to begin to quantify contributions of u.s.Pharmacists in providing clinical interventions that mitigate and control the pandemic.These interventions span the gamut of diagnosis, prevention, treatment, and support, intervening patient by patient with vaccines, diagnostic tests, convalescent plasma, monoclonal antibodies, antiviral medications, and supportive therapies.Methods review of published literature, relevant web pages, and queries to national and state professional pharmacy associations and government agencies.Results from february 2020 through september 2022, pharmacists and their teammates conducted >42 million covid-19 tests, provided >270 million vaccinations (including 8.1 million covid-19 vaccinations for long-term care residents) within community pharmacy programs alone, and provided >50 million influenza and other vaccinations per year.Pharmacists plausibly accounted for >50% of covid-19 vaccinations in the united states.Pharmacists prescribed, dispensed, and administered an uncounted number of antibody products and antiviral medications, including care for 5.4 million inpatients and innumerable outpatients.Using conservative estimates, pandemic interventions by pharmacists and teammates averted >1 million deaths, >8 million hospitalizations, and $450 billion in health care costs.Conclusions pharmacists and their teammates contributed to america's health and recovery during the covid-19 pandemic by providing >350 million clinical interventions to >150 million people in the form of testing, parenteral antibodies, vaccinations, antiviral therapies, and inpatient care.The number of lives touched and people cared for by pharmacists continues to rise.

Journal: Journal of the American Pharmacists Association : JAPhA (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, P.H.S.
Topical Treatment of Psoriasis Vulgaris: The Swiss Treatment Pathway.

Topical treatment is crucial for the successful management of plaque psoriasis.Topicals are used either as a stand-alone therapy for mild psoriasis or else in combination with uv or systemic treatment for moderate-to-severe disease.For the choice of a suitable topical treatment, the formulation matters and not just the active substances.This expert opinion paper was developed via a non-structured consensus process by swiss dermatologists in hospitals and private practices to illustrate the current treatment options to general practitioners and dermatologists in switzerland.Defining treatment goals together with the patient is crucial and increases treatment adherence.Patients' personal preferences and pre-existing experiences should be considered and their satisfaction with treatment and outcome regularly assessed.During the induction phase of "classical" mild-to-moderate psoriasis, the fixed combination of topical calcipotriol (cal) 50 μg/g and betamethasone dipropionate (bd) 0.5 mg/g once daily is frequently used for 4-8 weeks.During the maintenance phase, a twice weekly (proactive) management has proved to reduce the risk of relapse.Of the fixed combinations, cal/bd aerosol foam is the most effective formulation.However, the individual choice of formulation should be based on a patient's preference and the location of the psoriatic plaques.Tailored recommendations are given for the topical management of specific areas (scalp, facial, intertriginous/genital, or palmoplantar lesions), certain symptoms (hyperkeratotic or hyperinflammatory forms) as well as during pregnancy or a period of breastfeeding.As concomitant basic therapy, several emollients are recommended.If topical treatment alone does not appear to be sufficient, the regimen should be escalated according to the swiss s1-guideline for the systemic treatment of psoriasis.

Journal: Dermatology (Basel, Switzerland) (2021)
Publication types: Journal Article
Plant synthetic epigenomic engineering for crop improvement.

Efforts have been directed to redesign crops with increased yield, stress adaptability, and nutritional value through synthetic biology-the application of engineering principles to biology.A recent expansion in our understanding of how epigenetic mechanisms regulate plant development and stress responses has unveiled a new set of resources that can be harnessed to develop improved crops, thus heralding the promise of "synthetic epigenetics." in this review, we summarize the latest advances in epigenetic regulation and highlight how innovative sequencing techniques, epigenetic editing, and deep learning-driven predictive tools can rapidly extend these insights.We also proposed the future directions of synthetic epigenetics for the development of engineered smart crops that can actively monitor and respond to internal and external cues throughout their life cycles.

Journal: Science China. Life sciences (2022)
Publication types: Journal Article;Review
Development and characterization of swine primary respiratory epithelial cells and their susceptibility to infection by four influenza virus types.

Influenza viruses are a group of respiratory pathogens that have evolved into four different types: a, b, c, and d.A common feature is that all four types are capable of replicating and transmitting among pigs.Here, we describe the development of isogenous cell culture system from the swine respiratory tract to study influenza viruses.Phenotypic characterization of swine primary nasal turbinate, trachea and lung cells revealed high expression of cytokeratin and demonstrated tissue site dependent expression of tight junction proteins.Furthermore, lectin binding assay on these cells demonstrated higher levels of sia2-6gal than sia2-3gal receptors and supported the replication of influenza a, b, c, and d viruses to appreciable levels at both 33 and 37 °c, but replication competence was dependent on virus type or temperature used.Overall, these swine primary respiratory cells showed epithelial phenotype, which is suitable for studying the comparative biology and pathobiology of influenza viruses.

Journal: Virology (2019)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
A Closer Look at the Environmental Impact of Solar and Wind Energy.

Moving towards a sustainable society implies constant improvement in the way energy is supplied and consumed, with wider implementation of solar and wind energy facilities in stand-alone or hybrid configurations.The goal of this work is to evaluate the lifecycle performance (construction and operation-related impact) of large-scale solar and wind energy systems and to compare it with conventional coal and natural gas fossil fuel plants under similar conditions.Environmental analyses of energy conversion systems today usually neglect the construction-related environmental impact of fossil fuel plants, because it is significantly smaller than the impact related to the operation of the plant.However, the construction of large-scale renewable plants implies the use of rare materials, transport-related emissions, and other environmentally impactful activities.The plants evaluated here are configured and compared for similar emissions and similar power output.It is found that the life-cycle environmental impact of the renewable plants could, in some specific cases, exceed that of the fossil fuel plants.Understanding the reasons behind this and the possible limitations of the different technologies can help plan for sustainable energy systems in the future.Finally, solutions to minimize the impact of renewable energy are proposed for more environmentally friendly implementation and future research.

Journal: Global challenges (Hoboken, NJ) (2022)
Publication types: Journal Article
Stigmatization and Interpersonal Deviance Behaviors of Tour Guides: The Influence of Self-Identity Threat and Moral Disengagement.

Severe tour guide stigma is a significant problem hindering tourism development.Based on self-identity threat and moral disengagement theory, this study analyzed the relationship between tour guide stigmatization and tour guides' interpersonal deviance behavior.Survey data collected from 241 tour guides at three different points in time showed that tour guide stigmatization was positively related to tour guides' interpersonal deviance behavior and that self-identity threat mediated this effect.The results also show that moral disengagement moderated the effect of tour guides' self-identity threat on interpersonal deviance behavior, as well as the indirect effect of tour guide stigmatization on tour guides' interpersonal deviance behaviorviaself-identity threat.This study enriches theoretical research on tour guide stigmatization and offers practical suggestions for solving stigmatization problems for tour guides and organizations.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article
Perceptual Restoration in Speechreading by Adults With Profound Hearing Loss.

Perceptual restoration occurs when the brain restores missing segments from speech under certain conditions.It is investigated in the auditory modality, but minimal evidence has been collected during speechreading tasks.The authors measured perceptual restoration in speechreading by individuals with hearing loss and compared it to perceptual restoration in auditory speech by normally hearing individuals.Visual perceptual restoration for speechreading was measured in 33 individuals with profound hearing loss by blurring the keywords in silent video recordings of a speaker uttering a sentence.Auditory perceptual restoration was measured in 33 normally hearing individuals by distorting the keywords in spoken sentences.It was found that the amount of restoration was similar for speechreading through the visual modality by individuals with hearing loss and speech perception through the auditory modality by normally hearing individuals.These findings may facilitate understanding of speech processing by individuals with hearing loss.

Journal: American annals of the deaf (2022)
Publication types: Journal Article
Autologous platelet-rich plasma vs conventional dressing in the management of chronic diabetic foot ulcers.

Introduction diabetic foot ulcers (dfus) are a major complication of diabetes.Recently, considerable progress has been achieved in techniques that promote wound healing.Autologous platelet-rich plasma (prp) is one such technique that is gaining popularity.Platelet-rich plasma is thought to stimulate wound healing by releasing growth factors essential for healing.Objective this research aimed to study the efficacy of prp in managing chronic dfus.Materials and methods seventy-two patients with chronic dfus were equally divided into 2 groups.The first group was treated with activated prp injection and gel on the surface of the ulcer, and the second group was treated with conventional dressing using normal saline to irrigate the wound, followed by coverage with petrolatum gauze and sterile dressing.Results both methods of treatment improved healing, but there was a significant increase in healing rate among the prp group compared with the conventional dressing group (31/36 patients [86.11%] vs 23/36 patients [63.89%]; p =.029).Additionally, the healing duration was shorter in the prp group than in the conventional dressing group (10.90 weeks ± 3.40 standard deviation vs 13.48 weeks ± 3.37, respectively; p =.01).Conclusions the use of autologous prp results in a higher rate of wound healing in less time compared with conventional wound care in managing dfus.Platelet-rich plasma is an effective and promising treatment for chronic dfus; prp enables healing in less time.This is expected to positively affect the individual's performance and minimize long-term health care expenditure on foot ulcers.

Journal: Wounds : a compendium of clinical research and practice (2022)
Publication types: Journal Article
Selection of the Study Participants.

Editor's note: this is the second article in a new series on clinical research by nurses.The series is designed to give nurses the knowledge and skills they need to participate in research, step by step.Each column will present the concepts that underpin evidence-based practice-from research design to data interpretation.The articles will also be accompanied by a podcast offering more insight and context from the author.

Journal: The American journal of nursing (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Study on the coordination of cyclopentanocucurbit[5,6]uril with Fe3+, Co2+and Ni2+ions.

This paper reports the coordination of cyclopentanocucurbit[5]uril (cy p5q[5]) and cyclopentanocucurbit[6]uril (cy p6q[6]) with fe(cl o4)3, co(cl o4)2and ni(cl o4)2.Single crystal x-ray diffraction analysis shows the metal ions are directly coordinated with the portal of the cucurbit[n]uril to form a one-dimensional supramolecular chain or independent systems in the cy p5q[5]@fe(cl o4)3, cy p5q[5]@co(cl o4)2, cy p6q[6]@co(cl o4)2and cy p5q[5]@ni(cl o4)2complexes.In cy p6q[6]@fe(cl o4)3, the metal ion is not directly coordinated with the cucurbit[n]uril portal, but after forming fe(h2o)6, it interacts with the cucurbit[n]uril portalviaa hydrogen bond.The cy p6q[6]@ni(cl o4)2complex is quite special; in this system, there are both metal ions directly coordinated with the cucurbit[n]uril portal and free on the outer surface of the cucurbit[n]uril.

Journal: RSC advances (2022)
Publication types: Journal Article
Disruption of ETV6 leads to TWIST1-dependent progression and resistance to epidermal growth factor receptor tyrosine kinase inhibitors in prostate cancer.

Ets variant gene 6 (etv6) is a putative tumor suppressor and repressed by epidermal growth factor receptor (egfr) signaling in prostate cancer.Since egfr antagonists seem ineffective in castration-resistant prostate cancer (crpc), we aim to study the role of etv6 in the development of drug resistance.Methods etv6 target gene was validated by ch ip and promoter reporter assays.Correlation of etv6 and twist1 was analyzed in human clinical datasets and tissue samples.Migration, invasion, and metastasis assays were used to measure the cellular responses after perturbation of etv6 -twist1 axis.Proliferation and tumor growth in xenograft model were performed to evaluate the drug sensitivities of egfr-tyrosine kinase inhibitors (tkis).Results etv6 inhibits twist1 expression and disruption of etv6 promotes twist1-dependent malignant phenotypes.Importantly, etv6 is required to the anti-proliferation effects of egfr-tkis, partly due to the inhibitory function of etv6 on twist1.We also found that egfr-ras signaling is tightly controlled by etv6, supporting its role in tki sensitivity.Conclusions our study demonstrates that disruption of etv6 contributes to egfr-tki resistance, which is likely due to derepression of twist1 and activation of egfr-ras signaling.Our results implicate etv6 as a potential marker for predicting efficacy of an egfr-targeted anticancer approach.Combination treatment of twist1 inhibitors could sensitize the anti-proliferation effects of egfr-tkis.

Journal: Molecular cancer (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't