syedzayyan/paper_mill_benchmark huggingface dataset:
Finding humor in hormones: Oxytocin promotes laughing and smiling.

Oxytocin (ot) is known for facilitating interpersonal interactions in favorable conditions.Humor, on the other hand, is an interpersonal phenomenon that reduces social distance.In this study, we investigated whether ot would increase laughing and smiling in a favorable environment.Therefore, participants were asked to view a brief video clip of a comedy television program in the presence of an ingroup member after administration of either ot or a placebo.Results demonstrated that participants in the ot condition exhibited more laughing and smiling behavior over the course of viewing the video compared to participants in the placebo condition.Ot, however, neither affected self-reported affect nor perceived funniness of the clip.These findings indicate that ot, a hormone that can bolster attachment, also has the power to facilitate implicit social interactions by promoting visible and audible social signals, but does not affect the socially irrelevant inner cheerfulness.

Journal: Biological psychology (2022)
Publication types: Journal Article
Canine visceral leishmaniasis: Detection of Leishmania spp. genome in peripheral blood of seropositive dogs by real-time polymerase chain reaction (rt-PCR).

Visceral leishmaniasis (vl) is a zoonosis caused by the protozoa of the genus leishmania.Among the species, l.Infantum and/or l.Infantum (chagasi) are the most important species affecting the americas.Domestic dogs are the main reservoir of the parasite and participate effectively in the parasite' transmission cycle.The canine visceral leishmaniasis control program (pclv) adopted in brazil present as strategies the vector control, health education and serological diagnosis of cvl in dogs followed by culling of the seropositive ones.The resolution to eliminate seropositive dogs by euthanasia, when necessary, are the most controversial and least accepted by society.The diagnostic methods for canine visceral leishmaniasis, currently indicated and approved in brazil by the ministry of health from brazil are the dual path platform (dpp)®as a screening test and the enzyme immunoassay test (elisa®).This study aimed to verify the presence of leishmania spp.Dna in peripheral blood samples of dogs presenting positive serological results by dpp®and elisa®tests,throughreal-time polymerase chain reaction (rt-pcr), using the pair of primers 150-152 already described.For this purpose, were collected blood samples from 185 seropositive dogs among them, 41 (22%) exhibited some clinical signal of disease, whereas 144 (78%) was asymptomatic.The animals were also analyzed according to gender, race and hair size.According to the results of rt-pcr, it was observed that among the185 seropositive dogs analyzed, only 132 (71%) presented positive results for cvl and 53 (29%) presented negative results.From this, 41/41 symptomatic dogs were positive (100%), while among the asymptomatic dogs, 91/144 were positive (63, 2%) and 53/144 were negative (36, 8%).Concerning the hair size of seropositive dogs, we found that 41 (22%) had long hair, while 144 (78%) had short hair.No statistical significance occurred between the results of rt-pcr, elisa and dpp tests and the profile of the animals (gender, size of the dogs and hair size), probably due to the small number of samples and the sampling differences of each profile.But statistical significance occurred between the results of rt-pcr and the clinical evaluation, since the rt-pcr was positive in all symptomatic dogs.Thus, through these results, we reached at the following question, which may contribute to an important current debate: the dogs presenting cvl seropositive diagnosis confirmed by tests distributed by the ministry of health were in reality ill or were they seropositive by living in an endemic area of the disease?Would these asymptomatic seropositive dogs spread the disease to the inhabitants even presenting a low parasite charge circulating in the blood.

Journal: Microbial pathogenesis (2019)
Publication types: Journal Article
Biomechanical effects of daily physical activities on the lower limb.

The aim of this study was to determine the joint torques on the lower extremity during the daily physical activity movements of sit-to-stand, crouch down-stand up, and stair climbing without using an external device.Methods the study subject was a healthy 26-year-old male without any physical problems.A link-segment model was prepared according to the subject's individual anthropometric characteristics and transferred to the matlab(®) program.Joint torques were calculated using sim mechanicstm software.Motions were recorded by one digital video camera as the subject performed the movements (sit-to-stand from 20 cm and 40 cm height, crouch down-stand up, and climbing 10 cm and 20 cm high step) and the joint's position data was obtained using a digitization process.In addition, the vertical ground reaction forces were measured using a force plate in order to test the accuracy of the link-segment model.Lower extremity joint torques were calculated.Results maximum joint torques occurred in the knee joint.The knee and the ankle joints were the most loaded joint during the high step movement.The highest torques of the knee and ankle joint were 157.2 nm and 146 nm, respectively, during the movements.Knee joint torque and the ankle joint torque increased when the sitting height increased.The hip joint experienced the least amount of load during the movements.Conclusion the knee joint has enough strength against high torques during extension and flexion movement.Joint torques can be successfully calculated using a simulation process involving an inverse dynamics method without an external device mounted on the limbs.The obtained data can be used in the design of prosthetics and orthotics and for structural analysis of the bones.

Journal: Acta orthopaedica et traumatologica turcica (2015)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Strategies and lessons learned for smoke and Tobacco-Free policy change on community colleges with community-based support.

Community colleges face challenges to becoming smoke-free and have higher smoking prevalence rates than four-year colleges.This case study examines how sacramento taking action against nicotine dependence (stand), a community-based organization's project, achieved tobacco-free policies at california's second largest community college district.methods:data sources describing the stand policymaking activities (2001-2016) include evaluation reports and key informant interviews (n = 9) with community college nursing staff, former stand staff, and other sacramento tobacco control partners.Reports and interview transcripts were analyzed using content analysis.results:collecting campus data and engaging campus champions were key strategies to demonstrate internal support for stronger policies, as stand faced resistance from the district leadership.External momentum encouraged the campuses to adopt 100% smoke, tobacco and vape-free policies.conclusion:community-based organizations can facilitate long-term support for smoke and tobacco-free campus policymaking efforts at community colleges, as internal and external support is demonstrated for more comprehensive policies.

Journal: Journal of American college health : J of ACH (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Good outcome after repair of trauma-related anterosuperior rotator cuff tears-a prospective cohort study.

Anterosuperior rotator cuff tears with a displaced long head of the biceps tendon are most often trauma-related, and patients with these conditions often present with severe pain and shoulder dysfunction.Repair of the subscapularis and supraspinatus and a biceps tenodesis or a tenotomy are the recommended treatments based on retrospective studies.The aim of this study was to prospectively evaluate clinical and structural treatment outcome in a cohort of trauma-related anterosuperior injuries in patients with previously healthy shoulders.Materials and methods patients seeking care for a suspected rotator cuff injury after shoulder trauma were screened according to a protocol including clinical examination, baseline scoring with western ontario rotator cuff index (worc) and numeric rating scale of pain, ultrasound, and magnetic resonance imaging (mri).Those with anterosuperior injuries were offered surgical treatment, structured postoperative physiotherapy, and inclusion in the present study with 1-year follow-up, including mri, baseline scores, constant-murley score, and patient global impression of change.Thirty-three patients (78% men) with a mean age of 59 (40-76) years were included.Results all patients had a biceps pulley lesion, a displaced biceps tendon, and incomplete full-thickness subscapularis and supraspinatus tears.Six patients declined surgery.At follow-up, the operated patients reached a median worc score of 86% and a median change from baseline to follow-up of 50% (p = .0001).Pain decreased (p = .0001) at rest, at night, and during activity.The median constant-murley score was 86% of the contralateral nonoperated shoulder, 58% of the contralateral abduction strength recovered after surgery, and 86% reported that they were recovered or much improved.All repairs and tenodeses healed except for 2 supraspinatus tendons.The 6 nonoperated patients reached a median worc score of 90, a change in the median value from baseline to follow-up of 31, but reported more pain, and a smaller proportion considered themselves as recovered or much improved.In all patients, the 1-year mris had signal changes in the upper muscular portion of subscapularis, consistent with fatty infiltration, regardless of operative or nonoperative treatment.Conclusion anterosuperior rotator cuff injury with an associated pulley lesion and displaced long head of the biceps tendon may be treated successfully with surgery as the majority of patients in our cohort clinically recovered or were much improved without pain after a year.With a 1-year perspective, nonoperatively treated patients may also reach a reasonable clinical outcome.Independently of treatment or tendon healing, residual subscapularis muscle injury was seen, which may have long-term implications.

Journal: Journal of shoulder and elbow surgery (2021)
Publication types: Journal Article
Arbitrarily applicable spatial relational responding.

Spatial reasoning, where novel spatial relationships are inferred based on trained relationships, can be conceptualized as arbitrarily applicable spatial relational responding.Here, we conducted two experiments to develop and validate, for the first time, a laboratory procedure to establish arbitrarily applicable spatial relational responding in adult humans.In experiment 1, participants were trained on nonarbitrary spatial relational tasks designed to establish contextual cues for left of, right of, above, and below.Contextual cues were then used to train a series of arbitrary spatial relations involving four abstract shapes.Following training in a subset of arbitrary relations (a is left of b, b is above c, c is right of d), subsequent testing examined the emergence of untrained spatial relations (b is right of a, c is below b, d is left of c, d is below a and a is above d).When absent in initial tests, spatial relational responding was facilitated by a remedial training procedure incorporating nonarbitrary relational guidance.Participants showed patterns of spatial relational responding consistent with test relations.In experiment 2, a variant reversal design yielded predictable, reversed spatial relational responses.Overall, the present procedures represent the first empirical demonstration of arbitrarily applicable spatial relational responding and thus, arguably, the first functional analytic model of spatial reasoning.

Journal: Journal of the experimental analysis of behavior (2017)
Publication types: Journal Article
An Innovative Arteriovenous (AV) Loop Breast Cancer Model Tailored for Cancer Research.

Animal models are important tools to investigate the pathogenesis and develop treatment strategies for breast cancer in humans.In this study, we developed a new three-dimensional in vivo arteriovenous loop model of human breast cancer with the aid of biodegradable materials, including fibrin, alginate, and polycaprolactone.We examined the in vivo effects of various matrices on the growth of breast cancer cells by imaging and immunohistochemistry evaluation.Our findings clearly demonstrate that vascularized breast cancer microtissues could be engineered and recapitulate the in vivo situation and tumor-stromal interaction within an isolated environment in an in vivo organism.Alginate-fibrin hybrid matrices were considered as a highly powerful material for breast tumor engineering based on its stability and biocompatibility.We propose that the novel tumor model may not only serve as an invaluable platform for analyzing and understanding the molecular mechanisms and pattern of oncologic diseases, but also be tailored for individual therapy via transplantation of breast cancer patient-derived tumors.

Journal: Bioengineering (Basel, Switzerland) (2022)
Publication types: Journal Article
Decomposition of 2,4,6-trinitrotoluene (TNT) and 5-nitro-2,4-dihydro-3H-1,2,4-triazol-3-one (NTO) by Fe13O13nanoparticle: density functional theory study.

To obtain more insight into the mechanisms of the decomposition of energetic compounds, we performed a computational study of the interaction of fe13o13nanoparticles with two energetic molecules such as 2,4,6-trinitrotoluene (tnt) and 5-nitro-2,4-dihydro-3h-1,2,4-triazol-3-one (nto).The density functional theory using m06-2x, b3lyp, and blyp density functionals was applied.We found that the reactivity of these molecules strongly depends on the place of adsorption (so-called top and bottom planes of fe13o13).Namely, only the interaction with the bottom plane results in the thermodynamic characteristics of the decomposition that provide a medium reaction rate for the studied processes.Several pathways for such decomposition were found.One of them is the inter-complex oxygen transfer of nitro-group oxygen to fe13o13.This pathway results in the formation of adsorbed nitroso compounds.The second pathway describes a more complex decomposition that includes the transfer of the nitro-group oxygen accompanied by the hydrogen transfer.In all cases, the interaction of energetic molecules with fe13o13nanoparticles takes place along with a barrier-less electron transfer from fe13o13to tnt or nto species.

Journal: Environmental science and pollution research international (2022)
Publication types: Journal Article
Does Iron Deficiency Affect the Heart in Children?

Introduction it is well known that serum iron parameters are closely related to cardiovascular health.Iron deficiency may lead to significant cardiac problems, such as atrioventricular conduction abnormalities, and systolic and/or diastolic dysfunction.Studies related to the effect of iron deficiency on cardiac functions are limited in children.Therefore, the aim of this study was to evaluate the effect of low iron stores on cardiac repolarization parameters which are used to predict arrhythmia and cardiac functions.Materials and methods onehundred thirty-five children 2 to 18 years of age without structural heart disease who were referred to the pediatric cardiology department for various reasons such as chest pain, heart murmur, or evaluation before sports participation were evaluated prospectively.The cases were separated into 3 groups according to ferritin levels (group 1: ferritin 25 ng/m l [n=36]).Evaluations were made with detailed 12-lead surface electrocardiography (ecg) and transthoracic echocardiogram.Cardiac repolarization parameters were measured from surface ecg and systolic functions, left ventricular wall diameters were evaluated from transthoracic echocardiogram.Results eighty-four (62.2%) girls and 51 (37.8%) boys are included in the study.The average age of the groups was similar.In children with low ferritin levels (group 1); pw, pw max, and pw dis; qt, qtc, and qtc dis; tp-te, tp-te dis, tp-te/qt, and tp-te/qtc were significantly longer compared with the group 3 (p<0.05).There was a negative correlation between ferritin level and pw, p max, and pw dis; qt, qt dis, qtc, and qtc dis; tp-te, tp-te dis, tp-te/qt, and tp-te/qtc (p<0.05).No correlation was found between ferritin level and pw min.There was no difference between the groups in respect of ejection phase indices, heart wall measurements, and end-diastolic diameter measurements.Conclusion iron deficiency may be related to the tendency of arrhythmias in children without structural heart disease.Therefore, careful evaluation of ecg parameters of healthy children with low iron stores, and follow up with intermittent monitoring is highly important.

Journal: Journal of pediatric hematology/oncology (2022)
Publication types: Journal Article
Cancer-Related Care Costs and Employment Disruption: Recommendations to Reduce Patient Economic Burden as Part of Cancer Care Delivery.

Cancer survivors are frequently unprepared to manage the out-of-pocket (oop) costs associated with undergoing cancer treatment and the potential for employment disruption.This commentary outlines a set of research recommendations stemming from the national cancer institute's future of health economics research conference to better understand and reduce patient economic burden as part of cancer care delivery.Currently, there are a lack of detailed metrics and measures of survivors' oop costs and employment disruption, and data on these costs are rarely available at the point of care to guide patient-centered treatment and survivorship care planning.Future research should improve the collection of data about survivors' oop costs for medical care, other cancer-related expenses, and experiences of employment disruption.Methods such as microcosting and the prospective collection of patient-reported outcomes in cancer care are needed to understand the true sum of cancer-related costs taken on by survivors and caregivers.Better metrics and measures of survivors' costs must be coupled with interventions to incorporate that information into cancer care delivery and inform meaningful communication about oop costs and employment disruption that is tailored to different clinical situations.Informing survivors about the anticipated costs of their cancer care supports informed decision making and proactive planning to mitigate financial hardship.Additionally, system-level infrastructure should be developed and tested to facilitate screening to identify survivors at risk for financial hardship, improve communication about oop costs and employment disruption between survivors and their health-care providers, and support the delivery of appropriate financial navigation services.

Journal: Journal of the National Cancer Institute. Monographs (2022)
Publication types: Journal Article
I C U but I don't care: Callous-unemotional traits and approach-avoidance behaviour in conduct disorder.

And objectives conduct disorder (cd) is associated with deficits in social-emotional behaviour, such as increased levels of aggression.Callous-unemotional (cu-) traits foster those deficits and contribute to severe rates of instrumental aggression in cd.Previous studies of that increase in aggression have mainly focused on intentional aspects of behaviour.Unintentional behaviour, such as automatic approach and avoidance, has not been taken into account despite being highly relevant for behaviour.Therefore, the relevance of cu-traits for automatic actions and the feasibility of an approach-avoidance-task to measure those actions in cd-patients were investigated in a study series.Methods study 1 22 cd-patients executed an approach-avoidance task, where participants pushed or pulled pictures of emotional faces using a joystick.Cu-traits were assessed via parent-report.Study 2 28 cd-patients and 19 typically developing children (td) executed the aat.Again, cu-traits were assessed via parent-report.Results the aat was a feasible instrument to measure automatic action tendencies and revealed that, while td-children showed an avoidance bias towards angry faces, cd-patients showed a lack of automatic avoidance of anger.Across the whole sample (td and cd combined), cu-traits predicted less threat avoidance.Limitations the small sample size may have limited the power to detect smaller approach-avoidance tendencies towards other emotions.Conclusions the findings suggest that cd is associated with a lack of automatic avoidance of social threat and that cu-traits predict that lack of avoidance.Divergent automatic threat responding might underlie the extreme levels of instrumentally aggressive behaviour observed in cd-patients with distinctive cu-traits.

Journal: Journal of behavior therapy and experimental psychiatry (2022)
Publication types: Journal Article
Low hemoglobin is associated with worse outcomes via larger hematoma volume in intracerebral hemorrhage due to systemic disease.

Whether hemoglobin is associated with outcomes of a specific subtype of intracerebral hemorrhage (ich) is unknown.A total of 4643 patients with ich from a multicenter cohort were included in the analysis (64.0% male; mean age [sd], 58.3 [15.2] year), of whom 1319 (28.4%) had anemia on admission.The unsupervised consensus cluster method was employed to classify the patients into three clusters.The patients of cluster 3 were characterized by a high frequency of anemia (85.3%) and mainly composed of patients of systemic disease ich subtype (sd-ich; 90.0%) according to the smash-u etiologies.In sd-ich, a strong interaction effect was observed between anemia and 3-month death (adjusted odds ratio [a or] 4.33, 95% confidence interval [ci] 1.60-11.9,p= 0.004), and the hemoglobin levels were linearly associated with 3-month death (a or 0.75, 95% ci 0.60-0.92;p= 0.009), which was partially mediated by larger baseline hematoma volume (p= 0.008).This study demonstrated a strong linear association between low hemoglobin levels and worse outcomes in sd-ich, suggesting that hemoglobin-elevating therapy might be extensively needed in a specific subtype of ich.

Journal: MedComm (2022)
Publication types: Journal Article
Evaluation and treatment of facial feminization surgery: part II. lips, midface, mandible, chin, and laryngeal prominence.

Facial feminization surgery (ffs) refers to a set of procedures aimed at altering the features of a masculine face to achieve a more feminine appearance.In the second part of this twopart series, assessment and operations involving the midface, mandible, and chin, as well as soft tissue modification of the nasolabial complex and chondrolaryngoplasty, are discussed.Finally, we provide a review of the literature on patient-reported outcomes in this population following ffs and suggest a path forward to optimize care for ffs patients.

Journal: Archives of plastic surgery (2022)
Publication types: Journal Article
Magnetically tunable and enhanced spin Hall effect of reflected light in a multilayer structure containing anisotropic graphene.

In this paper, the magnetically tunable and enhanced photonic spin hall effect (pshe) of reflected light beam at terahertz frequencies is achieved by using a multilayer structure where anisotropic graphene is inserted.This enhanced pshe phenomenon results from the excitation of surface plasmon polariton (spp) at the interface between two dielectric materials.By considering the 4×4 transfer matrix method and the quantum response of graphene, the pshe of the reflected light can be enhanced by harnessing the anisotropic conductivity of graphene.Besides, the pshe can be tuned through the external magnetic field and structural parameters.This enhanced and tunable pshe approach is promising for fabricating anisotropic graphene-based terahertz spin devices and other applications in nanophotonics.

Journal: Optics express (2022)
Publication types: Journal Article