syedzayyan/paper_mill_benchmark huggingface dataset:
Multifunctional Therapeutic Approach of Nanomedicines against Inflammation in Cancer and Aging

Cancer is a fatal disorder that affects people across the globe, yet existing therapeutics are ineffective.The development of submicrometer transport for optimizing the biodistribution of systemically provided medications is the focus of nanomedicine.Nanoparticle‐ (np‐) based treatments may enable the development of novel therapeutic approaches to combat this deadly disorder.In multifunctional, multimodal imaging, and drug delivery carriers, nps generally play a major role.They have emerged as potential strategies for the invention of innovative therapeutic procedures in the last decade.The exponential growth of nanotechnologies in recent years has increased public awareness of the application of these innovative therapeutic approaches.Many tumor‐targeted nanomedicines have been studied in cancer therapy, and there is clear evidence for a significant improvement in the therapeutic index of antineoplastic drugs.Age‐related factors such as metabolic and physiological alterations in old age and inadequate animal models are currently understudied in nanomedicine and pharmacology.This review highlighted the most important targeting approaches, as well as public awareness, therapeutic advancements, and future prospects in age‐related metabolic variations, and tumor‐targeted nanomedicine studies.

Journal: Journal of Nanomaterials (2022)
Publication types: Review Article;
MRI Diagnosis and Pathological Examination of Axillary Lymph Node Metastasis in Breast Cancer Patients

In order to explore the characteristics and diagnostic value of magnetic resonance imaging (mri) in axillary lymph node metastasis of breast cancer, a total of 200 breast cancer patients diagnosed and treated from january 2021 to january 2022 are selected as the study subjects, and 200 patients are divided into an axillary lymph node metastasis group and a simple breast cancer group according to pathological results.The pathological results are used as the gold standard to determine the accuracy and diagnostic efficacy of mri results.A multivariate logistic regression method is used to analyze the influencing factors of mri image characteristics of breast cancer axillary lymph node metastasis.The experimental results show that mri has high application values in diagnosing axillary lymph node metastasis of breast cancer, which is worthy of clinical promotion and application.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Meta-Analysis of the Relationship between the Prognosis of Acute Cerebral Infarction Intravenous Lysis and Cerebral Microbleeds Based on Intelligent Medical Care

The accelerated pace of life leads to people’s unhealthy living habits such as irregular diet, irregular work and rest, and fatigued work.The incidence of acute cerebral infarction (aci) is increasing year by year.Intravenous thrombolysis is the best solution for clinical treatment of aci, but intravenous thrombolysis increases the risk of cerebral microbleeds and even seriously damages the brain of patients.It is crucial to analyze the relationship between intravenous thrombolysis of aci and cerebral microbleeds.Using intelligent medical methods such as bp neural network (bpnn), meta‐analysis was carried out on the prognosis of aci intravenous thrombolysis and cerebral microbleeds, and the basic data indicators, living habits indicators, and aci intravenous thrombolysis indicators of aci patients were analyzed.The experimental results showed that the odds ratios (or) of systolic blood pressure before aci intravenous thrombolysis, blood glucose concentration after aci intravenous thrombolysis, diastolic blood pressure before aci intravenous thrombolysis, and diastolic blood pressure after aci intravenous thrombolysis on cerebral microbleeds after aci intravenous thrombolysis were 0.97, 0.44, 0.13, and 0.07, respectively.Long‐term intravenous thrombolysis with aci, high systolic blood pressure after nihss thrombolysis with high scores, and blood glucose concentration before thrombolysis had or &gt;1, which were risk factors for cerebral microbleeds after intravenous thrombolysis with aci.Therefore, paying attention to the risk factors of cerebral microbleeds during aci intravenous thrombolysis can effectively reduce cerebral microbleeds after aci intravenous thrombolysis and improve the treatment efficiency of aci patients.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Meta-Analysis;
Meta-Analysis of the Main Components of Nanophotodynamics Combined with Traditional Chinese Medicine in the Treatment of Tumors

At present, cancer has become one of the main reasons that affect people’s life and health.With the development of nanomaterials and nanotechnology, tumor phototherapy such as photodynamic therapy, photothermal therapy, and combination therapy has been developed rapidly.Based on this, this paper proposes to take gastric cancer, esophageal cancer, liver cancer, intestinal cancer, and pancreatic cancer as the starting point and apply the methods of network meta‐analysis to comprehensively carry out the horizontal comprehensive evaluation of the efficacy and safety of traditional chinese medicine injections.It is hoped that this article can provide high‐quality evidence‐based medicine for clinical decision‐making and promote clinical rational drug use.The purpose of this paper is to study the meta‐analysis of the main components of tumor treatment with nanophotodynamics combined with traditional chinese medicine.The experimental results in this paper show that non‐small‐cell lung cancer has the largest number of evaluations, with 77 evaluations, accounting for 38.5% of the total frequency of tumor types.This may be related to the fact that lung cancer ranks first in the morbidity and mortality of malignant tumors.It is followed by the evaluation times of liver cancer and gastric cancer, which were 29 times and 25 times, respectively, accounting for 14.5% and 12.5% of the total frequency of tumor types.The therapeutic effect of sm‐np light therapy group on tumor was significantly higher than that of free ce6 light therapy group, and its destruction and killing effect on tumor tissue was greater.

Journal: Journal of Nanomaterials (2022)
Publication types: Meta-Analysis;
Meta-Analysis of the Effect of Glucocorticoids on Adult Acute Respiratory Distress Syndrome

S.The aim of this study is to investigate the effect of glucocorticoids in adult patients with acute respiratory distress syndrome (ards) by meta-analysis.Methods.Pub med, cochrane library, embase, cnki, wanfang database, and chinese biomedical literature database were searched.A randomized controlled trial (rcts) on glucocorticoid therapy in adult patients with ards was conducted from the time of database construction to december 2021.The content is about the randomized controlled trial (rct) of glucocorticoid treatment for adult patients with ards, without limiting the dose and course of glucocorticoid treatment.The quality of the included rcts was evaluated by using the bias risk assessment tool of the cochrane collaboration network, and the basic information, clinical features, and target outcomes of the literature were extracted.The effects of glucocorticoids on mortality and oxygenation index (pa o2/fi o2) in adult ards patients were evaluated by meta-analysis.Results.A total of 1,441 ards patients in 10 rcts were finally included, including 734 patients in the glucocorticoid treatment group (hormone group) and 707 patients in the conventional treatment group (control group).The 10 studies included have a good overall design and high quality.Compared with controls, glucocorticoid use was significantly associated with a decrease in mortality in adult ards patients (relative risk (rr) = 0.73, 95% confidence interval (95% ci) = 0.59–0.90, p = 0.003 ).Analysis showed that glucocorticoids significantly reduced the mortality in ards patients treated with medium and low doses of steroids (rr = 0.73, 95% ci = 0.58–0.92, p = 0.007 ).In patients with early administration of steroids, intervention with glucocorticoids was significantly associated with the decreased mortality in adult ards patients compared with controls (rr = 0.74, 95% ci 0.56–0.99, p = 0.04 ).Among patients with more than 7 days of hormone therapy, treatment with glucocorticoids was significantly associated with decreased mortality in adult ards patients (rr = 0.66, 95% ci = 0.50–0.88, p = 0.005 ) compared with controls.Glucocorticoids tended to improve pa o2/fi o2 in adult ards patients compared with controls, but the difference was not statistically significant (weighted mean difference (wmd) = 11.60, 95% = ci = 15.02–38.22, p = 0.39 ).Conclusion.Glucocorticoid therapy can reduce mortality in adult ards patients, and the benefit is more pronounced in patients with medium- and low-dose hormone therapy, early hormone administration, and hormone therapy for more than 7 days.However, no improvement in pa o2/fi o2 by glucocorticoid treatment was found, which needs to be confirmed by further studies.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Meta-Analysis;
Meta-Analysis of the Effect of Dietary Care on Nausea and Vomiting in Oncology Chemotherapy Patients

To evaluate the effect of dietary care on chemotherapy‐induced nausea and vomiting in oncology patients.Methods .A retrospective analysis of digestive symptoms was conducted in cancer patients admitted to our hospital, who received chemotherapy, and corresponding effective dietary care countermeasures were adopted.Results .After the nursing intervention, the incidence of digestive symptoms was significantly reduced, the quality of life was significantly improved (59.92 ± 6.57) vs.(37.95 ± 7.50), and the nursing satisfaction was significantly higher (91.67% vs.69.44%), with statistically significant differences ( p &lt; 0.05).Meta‐analysis showed that short‐term (0 to 3 months) dietary care could alleviate nausea and vomiting symptoms in chemotherapy patients ( p &lt; 0.001) and improve the survival quality of oncology patients ( p &lt; 0.01).The effect of long‐term (3–6 months) dietary care on the control of nausea and vomiting symptoms in chemotherapy patients was certain ( p &lt; 0.05), but the effect on the improvement of their quality of life ( p &gt; 0.05) was unclear.Conclusion .Dietary care can alleviate the symptoms of nausea and vomiting in tumor chemotherapy patients and improve the quality of life of short‐term chemotherapy tumor patients, so it can be recommended to strengthen the dietary management for tumor patients receiving chemotherapy.Patients receiving chemotherapy should be given corresponding dietary nutritional care according to their clinical symptoms in order to alleviate their adverse reactions, enhance their own immunity, and improve the prognosis of cancer patients.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Meta-Analysis;
lncRNA GAS5 Induces Cell Apoptosis in Acute Myeloid Leukemia by Targeting Nrf2

This study is aimed at investigating the molecular mechanism of lnc rna gas5-induced cell apoptosis in acute myeloid leukemia (aml) by targeting nrf2.Methods.The rna interfering technique was utilized to silence thp-1 in aml cell line, and lnc rna gas5 expression in cell line was determined by real-time pcr.Ed u experiment and flow cytometry were used to detect the apoptosis and proliferation ability of cells in different groups.Pd-l1, stat3, akt, and mmp9 expressions were determined by western blot.Results.The si-rna significantly inhibited the expression of lnc rna gas5 in thp-1 cells.Compared with the si-nc group, the difference in cell apoptosis between lnc rna gas5 and nrf2 groups was significant ( p &lt; 0.05 ).Compared with the lnc rna gas5 group, the number of apoptotic cells in the lnc rna gas5+nrf2 group significantly reduced ( p &lt; 0.05 ).Compared with the si-nc group, the differences in the levels of four proteins between lnc rna gas5 and nrf2 groups were significant ( p &lt; 0.05 ).In lnc rna gas5+nrf2 and lnc rna gas5 groups, pd-l1 expression increased, while the expression of stat3, akt, and mmp9 decreased.Conclusion.In aml cells, lnc rna gas5 with nrf2 could regulate the proliferation and apoptosis of aml cells.Lnc rna gas5 inhibited nrf2 expression, regulated cell apoptosis and proliferation, and further inhibited the progression of aml disease.

Journal: Disease Markers (2022)
Publication types: Research Article;
Levels of Serum IGF-1, HCY, and Plasma BNP in Patients with Chronic Congestive Heart Failure and Their Relationship with Cardiac Function and Short-Term Prognosis

To investigate the levels of serum insulin like growth factor-1 (igf-1), homocysteine (hcy), and plasma brain natriuretic peptide (bnp) in patients with chronic congestive heart failure (cchf) and their relationship with cardiac function and short-term prognosis.Methods.A total of 95 patients with cchf admitted to our hospital from october 2017 to december 2018 were selected as the observation group.Patients conform to grade ii∼iv of the new york heart association (nyha) heart function class.At the same time, the people with normal physical examination results were selected as a control group.Serum igf-1, hcy, and plasma bnp levels were detected in the two groups, and left ventricular end-diastolic diameter (lvdd) and left ventricular ejection fraction (lvef) were detected in the observation group.According to the follow-up results, the observation group was divided into the subgroup with good prognosis and the subgroup with poor prognosis.The relationship between the levels of serum igf-1, hcy, and plasma bnp among cardiac function and short-term prognosis were analyzed.Results.The serum igf-1 level of the observation group was lower than that of the control group, and the serum hcy and plasma bnp levels were higher than those of the control group ( p &lt; 0.05 ).Serum igf-1 level in grade iii of nyha was lower than that in grade ii, and serum hcy and plasma bnp levels were higher than those in grade ii.Serum igf-1 level in grade iv was lower than that in grade ii and grade iii, and serum hcy and plasma bnp levels were higher than those in grade ii and grade iii ( p &lt; 0.05 ).Serum igf-1 level was negatively correlated with lvdd and positively correlated with lvef.Serum hcy and plasma bnp levels were positively correlated with lvdd and negatively correlated with lvef ( p &lt; 0.05 ).There were 42 patients with poor prognoses (44.21%).Serum igf-1 levels of patients with poor prognosis were lower than those with good prognosis, and serum hcy and plasma bnp levels were higher than those with good prognosis ( p &lt; 0.05 ).Conclusion.The serum igf-1 level in patients with cchf decreased, and serum hcy and plasma bnp levels increased.Serum igf-1, hcy, and plasma bnp were correlated with cardiac function and have some clinical value for short-term prognosis.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Investigation on the Inhibitory Effect of Methotrexate on Rheumatoid Synovitis via the TLR4-NF-iκ/iB Pathway in a Rat Model

Rheumatoid arthritis (ra) is a rheumatoid immune system disease characterized by joint inflammation, resulting in synovial hyperplasia, articular cartilage damage or distortion, and extra‐articular involvement.The morbidity is higher and the treatments are not effective in clinical, and also no unified to the pathogenesis of such diseases.The aim of this paper is to establish a rat model of rheumatoid synovitis and observe the inhibitory effect of methotrexate on this disease.A total of 100 sd rats are selected and randomly divided into 5 groups, with 20 rats in each group.The cold and damp factors of rheumatoid arthritis are induced by cold water and the arthritis score is used to verify the model.Elisa is used to measure the protein expression of toll‐like receptor 4 (tlr4), nuclear factor kappa‐b (nf‐ κ b) and inflammation‐related factors, and spss25.0 is used for statistical analysis.The results show that there is no significant difference in inflammatory scores among the four groups except the control group.However, after 3 months of intervention, the inflammatory scores in the methotrexate groups are significantly lower than those in the model group, and in the methotrexate group, the higher the dose, the lower the inflammatory scores.The experimental results show that the messenger ribonucleic acid (m rna) and protein expressions of tlr4 and nf‐ κ b from high to low are in the order of model group &gt; low dose &gt; middle dose &gt; high dose &gt; control group, and the expression trend of inflammation‐related factors is the same as mentioned above.These results indicate that methotrexate can repair rheumatoid synovitis by inhibiting the inflammatory signaling pathway tlr4‐nf‐ κ b.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
International Logistics Management System Based on Cloud Computing Technology

In order to solve the problems of slow matching between supply and demand, information authenticity and security, and lack of trust in traditional logistics platforms, the author proposes an international logistics management system based on cloud computing technology.The system uses blockchain as the underlying technology, combined with related technologies such as smart contracts and nsga-ii algorithms, matches the supply and demand sides of cross-border logistics resources, writes the important information generated in the platform transaction into the blockchain, and carries out network-wide broadcast and consensus, so as to realize the intelligence of the transaction and the nontampering and traceability of the information.The experiment found that in the case set by this example, max z 1 = 57.139 , and max z 2 = 54.679 , meaning that the final matching result is as follows: p2, the cross-border logistics provider, is matched with u5, the consignor; p3 matches u9, p8 matches u4, p9 matches u3, p1 matches u6, p5 matches u1, p7 matches u2, p4 matches u7, p10 matches u8, and p8 matches u10.Satisfactory matching results show that the algorithm is effective.Experimental results show that the system can increase the transparency and sharing of cross-border logistics information, help to reduce forged data information, improve the level of automation and intelligence, and provide a reference for the application of blockchain technology in the field of cross-border logistics.

Journal: Wireless Communications and Mobile Computing (2022)
Publication types: Research Article;
Intelligent Deployment and Development Strategy of Agricultural Farmland Based on Improved Architecture of Internet of Things

Agricultural modernization has gradually become the direction of future agricultural development.With the improvement of the technical capacity of the internet of things, a new agricultural development model, namely, intelligent agriculture, has gradually emerged.It can not only improve the production efficiency of agriculture but also improve the efficiency of resource utilization.The main work of the software design of the terminal node is the io t network connection, the sensor work acquisition, and the packaging of the collected data for transmission and acceptance control to fundamentally alleviate the pressure on food security and ensure the sustainable development of china's agriculture.The experiment demonstrates that the curve temperature cycle of the agricultural greenhouse monitored by the system in this paper is normal, and the maximum temperature has been constant under different time cycles.For example, the maximum values of 5, 15, and 20 are all 0.67.

Journal: Mathematical Problems in Engineering (2022)
Publication types: Research Article;
Serum Level of CEACAM1 in Patients with Nonsmall Cell Lung Cancer and Its Clinical Significance in Cancer Tissue

To analyze the expression of ceacam1 in serum of patients with nonsmall cell lung cancer (nsclc) and to explore the correlation and clinical significance between the expression of ceacam1 and pathological parameters of nsclc tissue.Methods.A total of 100 patients with nsclc who underwent tumor resection were screened.Another 100 healthy patients in physical examination department were selected as control group.Venous blood and cancer tissue samples were collected.The expression of ceacam1, tgf-β, vegf-a, and il-8 was detected.Results.The results of various indicators in the lung cancer group were much higher than those in the healthy group; ceacam1 was significantly positively correlated with tgf-β expression.The later the clinical stage and the higher the degree of differentiation of cancer tissue specimens, the more the expression of ceacam1 in serum samples.Conclusions.The expression level of ceacam1 in the serum of nsclc patients is strongly correlated with tgf-β, vegf-a, and il-8, indicating that serum ceacam1 and tgf-β levels can predict the occurrence, progression, and prognosis of lung cancer and provide a target for future targeted therapy of lung cancer.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Screening of Prospective Plant Compounds as H1R and CL1R Inhibitors and Its Antiallergic Efficacy through Molecular Docking Approach

Allergens have the ability to enter the body and cause illness.Leukotriene is the widespread allergen which could stimulate mast cells to discharge histamine which causes allergy symptoms.An effective strategy for treating leukotriene-induced allergy is to find the inhibitors of leukotriene or histamine activity from phytochemicals.For this purpose, a library of 8,500 phytochemicals was generated using moe software.The structures of histamine-1 receptor and cysteinyl leukotriene receptor-1 were predicted by the homology modeling method through the swiss model.The phytochemicals were docked with predicted structures of histamine-1 and cysteinyl leukotriene receptor-1 in moe software to determine the binding affinity of the phytochemicals against the targets.Moreover, chemoinformatics properties and admet of phytochemicals were assessed to find the drug likeness behavior of compounds.Compound id 10054216 has the lowest s -score value for h-1 receptor that is -18.9186 kcal/mol which is lower than the value of standard -15.167 kcal/mol.The other compounds 393471, 71448939, 10722577, and 442614 also showed good s -score values than the standard.Moreover, compound id 11843082 has the lowest s -score value for cl1r that is -15.481 kcal/mol which is lower than the value of standard -12.453 kcal/mol.The other compounds 72284, 5282102, 66559251, and 102506430 also showed good s -score values than the standard.In this research article, we performed molecular docking to find the best inhibitors against h1r and cl1r and their antiallergic efficacy.This in silico knowledge will be helpful in near future for the design of novel, safe, and less costing h-1 receptor and cl1r inhibitors with the aim to improve human life quality.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;