syedzayyan/paper_mill_benchmark huggingface dataset:
Comparison of Efficacy and Safety of Recombinant Human Prourokinase and Alteplase in the Treatment of STEMI and Analysis of Influencing Factors of Efficacy

To compare the efficacy and safety of recombinant human prourokinase (rh pro-uk) and alteplase for thrombolytic therapy in acute st-segment elevation myocardial infarction (stemi) and to analyze the related factors affecting efficacy.Methods.From january 2017 to december 2019, 100 patients diagnosed with stemi were selected and randomly divided into the control group (n = 50) and the observation group (n = 50).Based on conventional treatments, the control group was treated with alteplase, and the observation group was treated with rh pro-uk, and both were treated for 7 days.After treatment, the vascular recanalization, left ventricular end-systolic diameter (lvesd), left ventricular end-diastolic diameter (lvedd), and left ventricular ejection fraction (lvef) were compared.The bleeding and major adverse cardiovascular events (mace) were recorded in both groups.According to the patient’s vascular recanalization, it was divided into two subgroups: recanalization group and occlusion group.Multiple logistic regression models were used to analyze the related factors that affect the efficacy.Results.The recanalization rate of the observation group (96.00%) was higher than that of the control group (84.00%) ( p &lt; 0.05 ).After treatment, lvds and lvedd in both groups were lower than those before treatment, and lvef was higher than that before treatment.The lvds and lvedd in the observation group were lower than those in the control group, and the lvef was higher than that in the control group ( p &lt; 0.05 ).The incidence of bleeding in the observation group (2.00%) was lower than that in the control group (12.00%), and the incidence of mace (4.00%) was lower than that in the control group (16.00%) ( p &lt; 0.05 ).Univariate analysis showed that age, smoking history, diabetes history, myocardial infarction history, infarct location, and intravenous thrombolysis time were related to the efficacy after treatment ( p &lt; 0.05 ).Multivariate logistic analysis showed that age, history of diabetes, vascular infarction site, and venous thrombolysis time were independent influencing factors after treatment ( p &lt; 0.05 ).Conclusion.Both rh pro-uk and alteplase thrombolytic therapy can effectively recanalize blood vessels and improve the cardiac function of patients with stemi.However, rh pro-uk has better effect than alteplase and is safer and worth promoting.The curative effect is related to age, diabetes history, vascular infarction site, and venous thrombolysis time.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Research Article;
Comparison of Effectiveness as well as Advantages and Disadvantages of Different Dimensions of Hysterosalpingo-Contrast Sonography for Diagnosis of Lesions Associated with Female Infertility

And objective.With social pressures and changes in lifestyle habits, the incidence of female infertility has increased in recent years.How to make timely and accurate assessment of the patency of the fallopian tubes in infertile women is of great importance in the clinical management of infertility.Therefore, this study aims to provide a reference for the future clinical application of hysterosalpingo-contrast sonography (hy co sy) by comparing the advantages and disadvantages of different dimensions of hy co sy for the diagnosis of female infertility.Methods.Forty subjects who underwent routine two-dimensional (2d) vaginal ultrasound, three-dimensional hy co sy (3d-hy co sy), and four-dimensional hy co sy (4d-hy co sy) examinations from january 2021 to july 2022 at the ultrasound department of pukou branch of jiangsu province hospital were enrolled to this study.Fallopian tubal recanalization by hydrotubation (ftrh) was used as the gold standard to compare the efficacy of 2d vaginal ultrasound, 3d-hy co sy, and 4d-hy co sy in assessing the subjects for the presence of polyps, myomas, and other occupants in the uterine cavity or uterine adhesions.Results.A total of 18 cases of uterine cavity lesions, 11 of pelvic lesions, and 11 of ovarian lesions were identified by ftrh, while 80 fallopian tubes were found in 40 patients and 71 tubal obstructions were detected by ftrh.Vaginal ultrasound assessment of uterine cavity, pelvis, ovarian lesions, and tubal obstruction was moderately consistent with ftrh ( kappa = 0.616 , 0.673, 0.654, and 0.640), 3d-hy co sy was in good agreement with ftrh ( kappa = 0.812 , 0.910, 0.906, and 0.894), and 4d-hy co sy was in good agreement with ftrh ( kappa = 0.914 , 0.903, 1.000, and 0.942), with 4d-hy co sy being in good agreement with ftrh had the highest agreement.Conclusion.4d-hy co sy can be used as an effective tool for clinical diagnosis of female tubal obstruction infertility and provide a reference basis for the design of subsequent clinical treatment plans.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Comparative Analysis of the Efficacy of Transurethral Bipolar Plasma Needle Electrode and Ring Electrode in the Treatment of Non-Muscle-Invasive Bladder Cancer

Bladder cancer is the most prevalent tumor of the urinary tract, ranking seventh in males and seventeenth in women.The gold standard for the definitive diagnosis and initial treatment of non-muscle-invasive bladder cancer is transurethral resection (tur) of the bladder tumor.The ability to accurately detect disease, typically in the presence of hematuria as well as to detect early recurrent tumors in patients with a history of nmibc, is critical to the successful treatment of non-muscle-invasive bladder cancer (nmibc).Unfortunately, the current biomarker landscape for nmibc is still evolving.Cystoscopy remains the gold standard, but it can still miss 10% of tumors.As a result, physicians frequently employ additional diagnostic tools to aid in the diagnosis of bladder cancer.The efficacy of transurethral bipolar plasma needle electrodes and ring electrodes in the treatment of non-muscle-invasive bladder cancer was compared and analyzed in this study.During our study, 100 patients with non-muscle-invasive bladder cancer admitted to our hospital between june 2019 and june 2020 were randomly assigned to a control group and an observation group, with 50 cases in each group.The observation group was given a bipolar plasma needle electrode, while the control group was given a bipolar plasma ring.Patients continued to receive bladder irrigation chemotherapy as well as traditional chinese medicine (tcm) treatment as part of our treatment plan, while the control group received only bladder irrigation chemotherapy.Clinical factors such as operational blood loss, catheter indention time, length of hospital stay, and others were compared between the two groups.When the risk grades in the two groups were compared, the observation group had fewer medium- and high-risk grades than the control group, but the control group had more low-risk grades, with statistical significance (p &lt; 0.05).

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Clinical Study;
Clinical Value of the Prognostic Nutrition Index in the Assessment of Prognosis in Critically Ill Patients with Stroke: A Retrospective Analysis

The purpose of study was to evaluate the association between prognostic nutritional index (pni) and all-cause mortality of critically ill patients with stroke.Methods.Clinical data derived from multiparameter intelligent monitoring in intensive care were analyzed.The primary endpoint was 30-day all-cause mortality; secondary endpoints were 90-day mortality and one-year cause mortality.The potential prognostic roles of pni were analyzed by cox proportional hazard models.The independent prognostic roles of pni in the cases were analyzed by smooth curve fitting.Results.Concerning 30-day mortality, the hr (95% ci) for a high pni (≥39.7) was 0.700 (0.544, 0.900; p = 0.00539 ), compared to a low pni (&lt;39.7).After adjusting for multiple confounders, the hr (95% ci) for a high pni (≥39.7) was 0.732 (0.547, 0.978; p = 0.03514 ), compared to a low pni (&lt;39.7).Regarding 90-day and one-year mortality, a similar trend was observed.In addition, a nonlinear association between pni and 30-day mortality was found.Using recursive algorithm and two-piecewise linear regression model, inflection point (ip) was calculated, which was 49.4.On the right side of the ip, there was a positive relationship between pni and 30-day mortality, and the effect size, 95% ci, and p value were 1.04 (1.01, 1.07), p = 0.0429 , respectively.On the left of the ip, the effect size, 95% ci, and p value were 0.97 (0.96, 0.99) and 0.0011, respectively.Conclusions.The pni was an independent predicting factor of 30-day, 90-day, and 1-year mortality of the critically ill patients with stroke.In addition, there was a u-shaped relationship between pni and all-cause mortality of stroke patients.Pni was a risk factor for the outcome of stroke when pni was &gt;49.4, while pni was a protective factor for outcome of stroke when pni was &lt;49.4.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Clinical Study of Stellate Ganglion Block Combined with General Anesthesia on Hemodynamics, Cognitive Function, and Gastrointestinal Function in Elderly Patients Undergoing Partial Hepatectomy

Partial hepatectomy under general anesthesia is prone to hemodynamic alterations, and stress reactions are the main contributing factors to postoperative cognitive function in elderly partial hepatectomy patients.Postoperative cognitive dysfunction increases the incidence of postoperative complications and long-term morbidity and mortality in elderly patients.With the increasing trend of aging population and the gradual increase of elderly people undergoing surgical treatment, it is especially important to study the corresponding prevention and treatment measures.In this study, a total of 90 patients with primary liver cancer who received hepatectomy in our hospital from july 2020 to july 2021 were included as the research subject.The changes in hemorheology, stress-related indexes, cognitive function, postoperative pain, and gastrointestinal function were compared between the two groups the results showed that sgb combined with general anesthesia can effectively reduce hemodynamic fluctuations in elderly partial hepatectomy patients, alleviate surgical stress, promote postoperative recovery of cognitive function and gastrointestinal function with high safety, and is worthy of clinical promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Clinical Study;
Clinical Promotion of Comfort Nursing Combined with Comprehensive Nursing in the Treatment of Severe Stroke Patients with Diabetes in ICU

To investigate the application value of comprehensive nursing combined with comfort nursing for severe stroke patients with diabetes in the intensive care unit (icu), as well as its effect on the incidence of pressure ulcers and aspiration.Methods .Between march 2019 and march 2021, 123 severe stroke patients with diabetes who were treated at our hospital were randomly assigned to one of two groups: the control group ( n = 61) or the study group ( n = 62).The control group received normal care, but the research group received comprehensive nursing as well as comfort nursing.The two patient groups were compared in terms of the effects of the clinical application.Results .The two groups did not differ significantly in general data ( p &gt; 0.05).The shorter icu monitoring and extubation times, the lower incidence of pressure ulcers, aspiration, and nosocomial infections, and higher self‐rating anxiety scale (sas) and self‐rating depression scale (sds) scores and a lower mos 36‐item short‐form health survey (sf‐36) score were all observed in the research group when compared to the control group ( p &lt; 0.05).Conclusion .For severe stroke patients with diabetes in the icu, comprehensive nursing combined with comfort nursing has a promising effect, significantly, lowering the risk of pressure ulcers, aspiration, and nosocomial infections, accelerating physical recovery, enhancing mental state, and ensuring a better prognosis, deserving general clinical promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2023)
Publication types: Clinical Study;
Clinical Observation on the Improvement of Serum Sex Hormone and Ovarian Function in Premature Ovarian Failure Patients with Deficiency-Cold Syndrome by Combining Wenjing Decoction with Tiaobu Chongren Acupuncture and Moxibustion

To explore the effect of wenjing decoction and tiaobu chongren acupuncture and moxibustion therapy on serum sex hormones and ovarian function recovery in premature ovarian failure (pof) patients with deficiency-cold syndrome.Methods.From february 2018 to october 2019, 119 poi patients with deficiency-cold syndrome who met the selection criteria were randomly divided into the control group (n = 59) and the observation group (n = 60).The control group was treated with hormone replacement therapy, and the observation group was treated with wenjing decoction and tiaobu chongren acupuncture and moxibustion therapy on the basis of the control group.Both groups were treated continuously for 3 months.After treatment, the clinical efficacy of the two groups was compared, the chinese medicine syndrome score, serum estradiol (e2), follicle-stimulating hormone (fsh), luteinizing hormone (lh), anti-mullerian hormone (amh) and bilateral antral follicle count (afc), mean ovarian volume, and endometrial thickness of the two groups before and after treatment were compared.Result.The effective rate of the observation group (93.10%) was higher than that of the control group (77.59%) ( p &lt; 0.05 ).After treatment, the index scores of traditional chinese medicine syndromes in two groups were lower than before ( p &lt; 0.05 ), and the observation group was lower than the control group ( p &lt; 0.05 ).The serum e2 and amh levels in the two groups increased, while fsh and lh levels decreased compared with before treatment, and the observation group improved significantly compared with the control group ( p &lt; 0.05 ).The bilateral afc, mean ovarian volume, and endometrial thickness of the two groups increased compared with before treatment, and the observation group was higher than the control group ( p &lt; 0.05 ).Conclusion.On the basis of hormone replacement therapy, the combination of wenjing decoction and tiaobu chongren acupuncture and moxibustion therapy is effective in treating pof patients with deficiency-cold syndrome, which can effectively regulate their serum sex hormone levels and promote the recovery of ovarian function.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Research Article;
Clinical Observation of Reduning Combined with Recombinant Human Interferon α-2b in the Treatment of Children with Viral Pneumonia

To observe the clinical efficacy of reduning injection combined with recombinant human interferon α-2b spray in the treatment of children with viral pneumonia.Methods.A total of 200 children with viral pneumonia over 2 years old who were admitted to the pediatrics department of the cangzhou central hospital from september 2018 to november 2020 were recruited and randomized into the control group and observation group at a ratio of 1 : 1, with 100 cases in each group.The children in the control group were given recombinant human interferon α-2b spray, and the children in the observation group were given reduning injection on the basis of the control group.The clinical symptoms and signs, clinical efficacy, levels of inflammatory mediators, and drug safety were compared between the two groups.Results.The t-test results showed that the disappearance time of body temperature, respiratory rate, pulmonary rales, and cough in the observation group was significantly shorter than that in the control group.The chi-square revealed a significantly higher total effective rate in the observation group vs.The control group.After treatment, the levels of il-1, il-6, tnf-α, and crp in the two groups were lower than the corresponding values before treatment, and greater reduction was observed in the observation group in relative to the control group (both p &lt; 0.05 ).The two groups have a similar safety profile.Conclusion.Reduning combined with recombinant human interferon α-2b produces a remarkable effect in the treatment of children with viral pneumonia, and it ameliorates clinical symptoms and reduces inflammatory response with a good safety profile.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Clinical Observation of Levothyroxine Sodium Combined with Selenium in the Treatment of Patients with Chronic Lymphocytic Thyroiditis and Hypothyroidism and the Effects on Thyroid Function, Mood, and Inflammatory Factors

The purpose of this study was to investigate the therapeutic effects of levothyroxine sodium combined with selenium treatment and single levothyroxine sodium treatment on patients with chronic lymphocytic thyroiditis and hypothyroidism and to analyze the effects of different treatment regimens on patients’ thyroid function, mood, and inflammatory factors, with the aim of providing a reference for clinical treatment.The subjects of the current study were 138 chronic lymphocytic thyroiditis (clt) patients with hypothyroidism admitted to our hospital from may 2016 to september 2019 and were randomly divided into a control group taking levothyroxine sodium (lt4) treatment and a combined group of lt4 combined with selenium treatment, with 69 cases each.Patients in both groups were evaluated for efficacy after 3 months of treatment, and their thyroid function was observed by total triiodothyronine (tt3), total thyroxine (tt4), thyroid stimulating hormone (tsh), thyroid peroxidase antibody (tpoab), and thyroid globulin antibody (tgab), and their mood changes were observed by self-rating anxiety scale (sas) and self-rating depression scale (sds) scores.The levels of inflammatory factors such as interleukin-2 (il-2), interleukin-10 (il-10), and tumor necrosis factor-α (tnf-α) were measured, and the occurrence of adverse drug reactions during the treatment period was observed and recorded in all patients.The results showed that the total effective rate of the combined group was significantly higher than that of the control group.The levels of tt3, tt4, tsh, tg ab, and tpoab, sas and sds scores, and levels of inflammatory factors such as il-2, il-10, and tnf-α were significantly improved in both groups after treatment.Compared with the control group, tgab, tpoab, il-2, tnf-α levels, and sas and sds scores decreased more and il-10 levels increased more in the combined group, while the differences of other indexes were not statistically significant.This suggests that lt4 has certain efficacy in treating clt with hypothyroidism, and the combined selenium treatment can improve the therapeutic effect of lt4 and can play a greater role in improving patients’ mood and immune and inflammatory responses.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Clinical Study;
Clinical Efficacy of Osimertinib in Patients with Advanced Non-Small Cell Lung Cancer and Its Effect on Serum CEA and VEGF Expression

To assess the clinical efficacy of osimertinib in patients with advanced non-small cell lung cancer and its effect on serum carcinoembryonic antigen (cea) and vascular endothelial growth factor (vegf) expression.Methods.Between july 2018 and january 2020, 80 patients with advanced non-small cell lung cancer were assessed for eligibility and recruited.The patients were assigned at a ratio of 1 : 1 to receive either the pc regimen (pemetrexed + cisplatin) (conventional group) or osimertinib (experimental group).The primary endpoint was the clinical efficacy, and the secondary endpoints were the adverse events, expression of serum cea and vegf, and 2-year survival.Results.Osimertinib was associated with a significantly higher response rate and disease control rate versus pemetrexed plus cisplatin ( p &lt; 0.05 ).Osimertinib resulted in a significantly lower incidence of adverse events versus the pc regimen ( p &lt; 0.05 ).Patients given osimertinib had significantly lower levels of cea and vegf versus those given pemetrexed plus cisplatin ( p &lt; 0.05 ).Osimertinib was associated with a significantly higher 1-year and 2-year survival rate versus pemetrexed plus cisplatin conclusion.Osimertinib could inhibit the expression of serum cea and vegf in patients with advanced non-small cell lung cancer and reduce the adverse events with significant efficacy, so it is worthy of clinical promotion and application.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Clinical Efficacy of Modified Yiwei Shengyang Decoction Combined with FOLFOX4 Chemotherapy Regimen in the Treatment of Advanced Gastric Cancer and Its Effect on Tumor Marker Levels

To study the clinical efficacy of modified yiwei shengyang decoction combined with folfox4 chemotherapy regimen in the treatment of advanced gastric cancer and its effect on tumor marker levels.Methods.A total of 106 patients with advanced gastric cancer who were treated in our hospital from september 2019 to september 2021 were recruited and assigned via random number allocation to receive either folfox4 chemotherapy (control group) or modified yiwei shengyang decoction plus folfox4 chemotherapy (observation group).Outcome measures included clinical efficacy and tumor marker levels.Results.Modified yiwei shengyang decoction plus folfox4 chemotherapy was associated with a significantly higher efficacy (86.79%, including 22 (41.51%) cases of complete response (cr), 24 (45.28%) cases of partial response (pr), 6 (11.32%) cases of stable disease (sd), and 1 (1.89%) case of progressive disease (pd)) compared to folfox4 chemotherapy alone (47.16%, including 10 (18.87%) cases of cr, 15 (28.30%) cases of pr, 21 (39.62%) cases of sd, and 7 (13.21%) cases of pd) ( p &lt; 0.05 ).There was no significant difference in the levels of cea and ca19-9 between the two groups before treatment ( p &gt; 0.05 ).Modified yiwei shengyang decoction plus folfox4 chemotherapy resulted in significantly lower levels of carcinoembryonic antigen (cea) and carbohydrate antigen 19-9 (ca19-9) (2.08 ± 0.47, 15.12 ± 6.74) compared to folfox4 chemotherapy alone (5.46 ± 1.84, 31.82 ± 7.48) ( p &lt; 0.05 ).Conclusion.Modified yiwei shengyang decoction plus folfox4 chemotherapy regimen is effective in the treatment of advanced gastric cancer.It regulates the levels of various serum tumor markers in patients and controls the disease, so it is worthy of clinical application and promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;