syedzayyan/paper_mill_benchmark huggingface dataset:
Do the Number, Size, and Position of Partially Threaded Screws Affect the Radiological Healing of Surgically Treated Displaced Femoral Neck Fractures? A Review of 136 Children.

And objectives:the quantity, size, and position of implants might affect the fracture healing process of surgically treated displaced pediatric femoral neck fractures (pfnfs).The aim of this retrospective multicenter study was to evaluate the correlation between the time needed to achieve radiological union and the number, size, and location of the partially threaded cannulated screws (ptcss) in children with displaced pfnfs.materials and methods:a retrospective review of 136 children (mean age: 10.6 ± 3.8 years) with displaced pfnfs treated by two (n= 103) or three (n= 33) ptcss was carried out.Student'st-tests, one-way anova, cox regression analysis, and multiple linear regression analyses were performed to investigate the variables affecting the time needed to achieve radiological fracture healing according to the number, size, and position of ptcss, as assessed on plain radiographs.results:a total of 132 hips achieved union at an average of 3.2 ± 1.6 months after the initial surgery.The time needed to achieve union in the patients treated with two or three ptcss was comparable (p= 0.36).Among the fractures treated by two ptcss, the time needed to achieve union did not correlate with the size of the implant (p= 0.122), or with the angulation between the ptcss on anterior-posterior (p= 0.257) and lateral radiographs (p= 0.547).The time needed to achieve union in the fractures that were fully compressed by the implants was similar to the partially compressed fractures (p= 0.08).conclusions:the number, size, and position of the ptcss do not affect the radiological healing in the children with displaced pfnfs treated surgically.

Journal: Medicina (Kaunas, Lithuania) (2022)
Publication types: Journal Article
Cell cortex regulation by the planar cell polarity protein Prickle1.

The planar cell polarity pathway regulates cell polarity, adhesion, and rearrangement.Its cytoplasmic core components prickle (pk) and dishevelled (dvl) often localize as dense puncta at cell membranes to form antagonizing complexes and establish cell asymmetry.In vertebrates, pk and dvl have been implicated in actomyosin cortex regulation, but the mechanism of how these proteins control cell mechanics is unclear.Here we demonstrate that in xenopus prechordal mesoderm cells, diffusely distributed, cytoplasmic pk1 up-regulates the f-actin content of the cortex.This counteracts cortex down-regulation by dvl2.Both factors act upstream of casein kinase ii to increase or decrease cortical tension.Thus, cortex modulation by pk1 and dvl2 is translated into mechanical force and affects cell migration and rearrangement during radial intercalation in the prechordal mesoderm.Pk1 also forms puncta and plaques, which are associated with localized depletion of cortical f-actin, suggesting opposite roles for diffuse and punctate pk1.

Journal: The Journal of cell biology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Worsening pain and quality of life for spine surgery patients during the COVID-19 pandemic: Roles of psychological distress and patient activation.

Public health measures during the covid-19 pandemic have disrupted access to basic resources (income, food, housing, healthcare).The effects may impact patients differently based on socioeconomic status (ses), pre-existing psychological distress, and patient activation (knowledge, skills, and motivation to manage healthcare).We examined changes in access to basic resources and in pain and health-related quality of life (hrqo l) during the pandemic and determined how pre-existing psychological distress and patient activation are associated with exacerbation or mitigation of effects on pain and hrqo l.Methods this cross-sectional study assessed 431 patients in a longitudinal-outcomes registry who underwent or scheduled spine surgery at our institution and were surveyed about covid-19 effects on accessing basic resources.We assessed pain (numeric rating scale) and hrqo l (promis 29-item profile).Information on preoperative ses, psychological distress, patient activation, pain, and hrqo l was collected previously.We compared access to basic resources by ses.We compared changes from pre-covid-19 to covid-19 assessments of pain and hrqo l and proportions of patients reporting worsened pain and hrqo l stratified by psychological distress.We analyzed associations between patient activation and negative effects on hrqo l using multivariable linear regression.Alpha=0.05.Results respondents reported minor disruptions in accessing basic resources (no difference by ses) but significant worsening of back (p=.027) and leg pain (p=.013) and hrqo l (physical function, fatigue, p<0.001; satisfaction with participation in social roles, p=0.048) during covid-19.Psychological distress was associated with clinically relevant worsening of back, pain, leg pain, and physical function all, (p<0.05).High patient activation was associated with less impairment of physical function (p=0.03).Conclusion patients with pre-existing psychological distress experienced greater worsening of pain and hrqo l.High patient activation appeared to mitigate worsening of physical function.Providers should screen for psychological distress and patient activation and enhance supports to manage pain and maintain hrqo l in at-risk patients.level of evidence:iii.

Journal: North American Spine Society journal (2022)
Publication types: Journal Article
Hyperlipidemia in patients newly treated with anticonvulsants: A population study.

To determine the incidence of hyperlipidemia after first anticonvulsant treatment for seizures, using a large us administrative claims database.Methods we obtained data from the market scan commercial and medicare databases for 2005-2009 for all adult patients newly treated with an anticonvulsant for seizures who had no previous history of hyperlipidemia or treatment with a lipid-lowering agent.We divided the population based upon whether they were treated with an enzyme-inducing anticonvulsant (phenytoin, carbamazepine, phenobarbital, primidone) or a noninducing anticonvulsant (all others).The primary outcome measure was a new diagnosis of hyperlipidemia during subsequent follow-up.We accounted for a large number of demographic and clinical covariates.Results of 11 374 subjects, 8778 (77%) were prescribed noninducers and 2596 (23%) were prescribed inducers.New hyperlipidemia diagnoses were seen in 14.6% of the patients started on inducing anticonvulsants and 10.7% of the patients started on noninducing anticonvulsants (p < .001).Both hyperlipidemia and the use of inducers were significantly associated with older age and male gender.After accounting for covariates, inducer prescription was still associated with 23% higher odds of a subsequent diagnosis of hyperlipidemia (odds ratio = 1.225, 95% confidence interval = 1.066-1.408, p < .001).Significance the use of enzyme-inducing anticonvulsants in patients with newly diagnosed epilepsy was associated with a significant increase in subsequent diagnoses of hyperlipidemia, suggesting that the lipid-elevating properties of these agents are of genuine clinical importance.This adds to the body of data demonstrating that these agents are likely associated with additional hassle, cost, and morbidity.

Journal: Epilepsia (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A new large species of gecko of the genus Hemidactylus Oken, 1817 (Reptilia: Sauria: Gekkonidae) from the Eastern Ghats, India.

A new large species of gecko superficially resembling hemidactylus maculatus duméril & bibron and its allied large hemidactylus is described from eastern ghats.The new species, hemidactylus kangerensis sp.Nov.Can be easily distinguished from members of the h.Maculatus complex based on the number of femoral pores, i.e.18-21 on each side, separated medially by 4 non-pored scales.A phylogenetic analysis based on partial sequence of mitochondrial gene cytochrome b shows that the gecko is a member of the "h.Prashadi" clade and is sister to h.Maculatus, from which it differs in an uncorrected pairwise sequence divergence of 10%.The discovery of a new large gecko from eastern ghats advocates the need for biodiversity assessment across the neglected eastern ghats.

Journal: Comptes rendus biologies (2017)
Publication types: Journal Article
Safety and Benefit of Transesophageal Echocardiography in Liver Transplant Surgery: A Position Paper From the Society for the Advancement of Transplant Anesthesia (SATA).

More anesthesiologists are routinely using transesophageal echocardiography (tee) during liver transplant surgery, but the effects on patient outcome are unknown.Transplant anesthesiologists are therefore uncertain if they should undergo additional training and adopt tee.In response to these clinical questions, the society for the advancement of transplant anesthesia appointed experts in liver transplantation and who are certified in tee to evaluate all available published evidence on the topic.The aim was to produce a summary with greater explanatory power than individual reports to guide transplant anesthesiologists in their decision to use tee.An exhaustive search recovered 51 articles of uncontrolled clinical observations.Topics chosen for this study were effectiveness and safety because they were a major or minor topic in all articles.The pattern of clinical use was a common topic and was included to provide contextual information.Summarized observations showed effectiveness as the ability to make a new and unexpected diagnosis and to direct the choice of clinical management.These were reported in each stage of liver transplant surgery.There were observations that tee facilitated rapid diagnosis of life-threatening conditions difficult to identify with other types of monitoring commonly used in the operating room.Real-time diagnosis by tee images made anesthesiologists confident in their choice of interventions, especially those with a high risk of complications such as use of anticoagulants for intracardiac thrombosis.The summarized observations in this systematic review suggest that tee is an effective form of monitoring with a safety profile similar to that in cardiac surgery patients.

Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (2020)
Publication types: Journal Article;Systematic Review
Hypothesis generation: Quantitative research to levator ani muscle injury based on MRI texture analysis.

Patients with pelvic organ prolapse (pop) mostly have injury to the levator ani muscle (lam).We aimed to assess lam injury in pop patients by quantifying texture feature (tf) ratios between the lam and the obturator internus muscle (oim) using texture analysis.Methods this study retrospectively enrolled 32 participants, including 24 patients with pop and eight people with normal pelvic floor muscles.Tfs of the lam and the oim were extracted using lifex version 6.30, and an independent samples t-test was performed to determine tf ratios characterizing lam injury.After dimension reduction and binary logic analysis, the optimal tf ratio was obtained and the lam injury quantitative evaluation was proposed.Spearman's correlation was performed to explore the correlations between tf ratios and clinical characteristics.We compared the diagnostic performance of quantitative evaluation and visual evaluation.Results there were significant differences in 13 tf ratios between the pop and control groups.The area under the receiver operating characteristic curve of the integrated tf ratio was 0.948.Integrated tf ratio was significantly correlated with body mass index, pregnancies, and vaginal deliveries but had no correlation with lam volume, hiatal area or abortions.Compared with the visual evaluation, the diagnostic accuracy of the quantitative evaluation had improved by 63.2% and 14.3% in the "minor defect" and "major defect" categories, respectively.Conclusion the integrated tf ratio can be used as a new quantifiable index to characterize lam injury.The tf evaluation provides a potential role in lam injury noninvasive diagnostic.

Journal: The journal of obstetrics and gynaecology research (2022)
Publication types: Journal Article
Integrated Genome-Wide Analysis of MicroRNA Expression Quantitative Trait Loci in Pig Longissimus Dorsi Muscle.

Determining mechanisms regulating complex traits in pigs is essential to improve the production efficiency of this globally important protein source.Micro rnas (mi rnas) are a class of non-coding rnas known to post-transcriptionally regulate gene expression affecting numerous phenotypes, including those important to the pig industry.To facilitate a more comprehensive understanding of the regulatory mechanisms controlling growth, carcass composition, and meat quality phenotypes in pigs, we integrated mi rna and gene expression data fromlongissimus dorsimuscle samples with genotypic and phenotypic data from the same animals.We identified 23 mi rna expression quantitative trait loci (mi r-e qtl) at the genome-wide level and examined their potential effects on these important production phenotypes through mi rna target prediction, correlation, and colocalization analyses.One mi r-e qtl mi rna, mi r-874, has target genes that colocalize with phenotypic qtl for 12 production traits across the genome including backfat thickness, dressing percentage, muscle p h at 24 h post-mortem, and cook yield.The results of our study reveal genomic regions underlying variation in mi rna expression and identify mi rnas and genes for future validation of their regulatory effects on traits of economic importance to the global pig industry.

Journal: Frontiers in genetics (2021)
Publication types: Journal Article
Enabling the Circular Economy Transition in Organizations: A Moderated Mediation Model.

The notion of corporate environmental responsibility has been extensively researched in the literature so far, but less is known about how this concept fits into the circular economy paradigm.We performed a moderated mediation analysis in order to identify the mechanism that links corporate environmental responsibility with readiness for change towards a circular economy business model.The findings from 311 respondents show that there is a positive association between corporate environmental responsibility and the readiness for change to a circular model, mediated by perceived circular economy drivers.In addition, perceived circular economy barriers hinder this positive relationship, acting as a buffer.These findings can further contribute to the elaboration of a conceptual framework for embedding circular economy in the corporate social responsibility strategies of organizations.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Bacteria in Fluid Flow.

Bacteria thrive in environments rich in fluid flow, such as the gastrointestinal tract, bloodstream, aquatic systems, and the urinary tract.Despite the importance of flow, how flow affects bacterial life is underappreciated.In recent years, the combination of approaches from biology, physics, and engineering has led to a deeper understanding of how bacteria interact with flow.Here, we highlight the wide range of bacterial responses to flow, including changes in surface adhesion, motility, surface colonization, quorum sensing, virulence factor production, and gene expression.To emphasize the diversity of flow responses, we focus our review on how flow affects four ecologically distinct bacterial species: escherichia coli, staphylococcus aureus, caulobacter crescentus, and pseudomonas aeruginosa.Additionally, we present experimental approaches to precisely study bacteria in flow, discuss how only some flow responses are triggered by shear force, and provide perspective on flow-sensitive bacterial signaling.

Journal: Journal of bacteriology (2023)
Publication types: Journal Article;Review;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Traditional Chinese Practice, A Promising Integrative Intervention for Chronic Non-Infectious Disease Management.

The number of people with chronic diseases rises rapidly in recent years worldwide.Except for drug medication, mind-body exercises are indispensable for chronic disease management.Traditional chinese practice (tcp), as an integrative intervention, is known as an effective means to keep in good health and fitness, as well as help regulate emotion.This paper introduces the domestic and overseas studies on effectiveness of tcp for chronic diseases, and explores the key action links from three aspects, including functional training of multiple-joint guided by consciousness, relieving psychological risk factors, improving respiratory and digestive function, blood and lymph circulation through respiratory training, and regulation of nerve, metabolic, and immune system.Finally, the authors discussed how to integrate tcp in the chronic disease management, and put forward that the practice methods and evaluation standard should be assessed academically.

Journal: Chinese journal of integrative medicine (2018)
Publication types: Journal Article
Dual therapy with clopidogrel and aspirin prevents early neurological deterioration in ischemic stroke patients carrying CYP2C19*2 reduced-function alleles.

To investigate the associations between cyp2c19 genotypes and early neurological deterioration (end), and to carry out a stratified analysis of the effectiveness of clopidogrel alone and dual antiplatelet therapy with clopidogrel and aspirin for prevention of end according to cyp2c19 genotypes in ischemic stroke (is) patients.Methods this was a prospective, observational, two-center study.A total of 375 acute is patients were enrolled.Platelet aggregation was measured before and after the 7- to 10-day treatment.Clopidogrel resistance (cr) was assessed by adenosine diphosphate-induced platelet aggregation.Cyp2c19*2 (rs4244285) and cyp2c19*3 (rs4986893) genotypes were examined using mass spectrometry.The primary outcome was end during the 10 days after admission.Results among the 375 patients, 144 patients received clopidogrel alone, 231 patients took clopidogrel plus aspirin, 153 patients (40.8%) had cr, 95 patients (25.3%) experienced end.Patients carrying cyp2c19*2 ag/aa (cyp2c19*2 reduced-function alleles) and cr were associated with a higher risk for end, and dual antiplatelet therapy was associated with a lower risk for end.Stratified analyses revealed that there was no significant difference in the incidence of end between patients not carrying cyp2c19*2 reduced-function alleles who received clopidogrel plus aspirin and those who received clopidogrel alone.However, dual antiplatelet therapy was more effective at reducing end and inhibiting platelet aggregation than clopidogrel alone for carriers of at least one cyp2c19*2 reduced-function allele.Conclusions the frequency of end was very high after acute is in the chinese population.Dual therapy with clopidogrel and aspirin may be adequate for patients carrying cyp2c19*2 reduced-function alleles.Genetic testing may be useful to guide personalized and precise antiplatelet therapy.Clinical trial registration information the study described here is registered at / (unique identifier: chi ctr-och-14004724).

Journal: European journal of clinical pharmacology (2018)
Publication types: Comparative Study;Journal Article;Multicenter Study;Observational Study
Bioactivities of Lentinus polychrous and Ganoderma lucidum (Agaricomycetes) Polysaccharide Extracts.

This study aimed to compare the bioactivities of lentinus polychrous polysaccharide extracts with ganoderma lucidum.Three hot water-extracted polysaccharide fractions of l.Polychrous (lpe), including immature fruiting bodies (im-lpe), mature fruiting bodies (ma-lpe), and mycelium (my-lpe), were analyzed for their phytochemical contents and bioactivities (e.g., anticancer, antiviral, anti-inflammatory, and immunomodulatory effects) compared with g.Lucidum extract (gle).Although gle had the highest total phenolic and protein contents and lower carbohydrate content than lpe, im-lpe showed strong inhibition on hep g2 cell proliferation as did gle.Gle and lpe showed antiviral effects on herpes simplex virus-1 and the relative antiproliferative activity was from im-lpe > my-lpe > ma-lpe.However, im-lpe showed the best protective activity on the viral attachment step with some virucidal effects.Moreover, all lpe showed selective and stronger inhibitory effects on lps-induced raw264.7 macrophages than those of gle on genetic expression.Considering the 50% inhibitory concentration values, my-lpe possessed the strongest inhibitory activity on the expression of cyclooxygenase-2 and inducible nitric oxide synthase.However, ma-lpe had the strongest inhibitory effects on interleukin-1β and tumor necrosis factor-α gene expression.The extracts increased splenocyte proliferation under mycohaemagglutinin induction with a relative order of my-lpe > gle > ma-lpe = im-lpe.In conclusion, lpe showed positive effects and stronger activity than g.Lucidum.L.Polychrous may have potential for use as an ingredient in functional foods.

Journal: International journal of medicinal mushrooms (2021)
Publication types: Journal Article
Preoperative Predictive Features of Invasive Carcinoma Among Intraductal Papillary Mucinous Neoplasm of the Pancreas.

Noninvasive intraductal papillary mucinous neoplasms (ipmns) theoretically do not metastasize.The purpose of this study is to preoperatively distinguish invasive carcinomas associated with ipmn from noninvasive ipmn.Methods a total of 131 patients who underwent surgical resection for ipmn were retrospectively analyzed to identify the predictors of invasive carcinoma, based on the international association of pancreatology consensus guidelines.Results of the 131 patients, 29 (22%) had invasive carcinomas and 102 (78%) had noninvasive ipmn.An enhancing mural nodule (mn) greater than or equal to 5 mm, obstructive jaundice, an abrupt change in the caliber of the pancreatic duct (pd) with distal pancreatic atrophy, and lymphadenopathy were the significant predictors of invasive carcinoma in univariate analysis.The optimal cutoff value for the size of the enhancing mn to differentiate invasive carcinoma was 13 mm.In multivariate analysis, enhancing mn greater than or equal to 13 mm, obstructive jaundice, and an abrupt change in the pd caliber were the independent predictors.When all these factors were absent, only 17% were invasive carcinomas.Conclusions enhancing mn greater than or equal to 13 mm, obstructive jaundice, and an abrupt change in the pd caliber were predictive factors for invasive carcinoma.Systematic lymph node dissection may be omitted when a high-risk patient has none of these factors.

Journal: Pancreas (2022)
Publication types: Journal Article
Diversity ofCantharellus(Cantharellales, Basidiomycota) in China with Description of Some New Species and New Records.

Cantharellusis a well-known genus of edible mushrooms, belonging to the family hydnaceae in the class agaricomycetes.In this study, a phylogenetic overview of cantharellussubg.cinnabarinusand c.Subg.parvocantharellusin china is carried out with the description of four new species.Species description are based on morphological characters of basidiomata and phylogenetic analyses of multi-locus dataset of 28s +tef1 +rpb2.Among the new species, two species,c.Chrysanthusand c.Sinocinnabarinus,belong to c.subg.cinnabarinusand two new species,c.Convexusand c.Neopersicinus, belong to c.subg.parvocantharellus.Species delimitation characters of the new taxa are compared with closely related species.In addition, three new records of cantharellusare reported for china:c.Albovenosusand c.Citrinusof subg.cinnabarinusand c.Koreanusof subg.parvocantharellus.A key to the species of subg.cinnabarinusin china was provided.

Journal: Journal of fungi (Basel, Switzerland) (2022)
Publication types: Journal Article