syedzayyan/paper_mill_benchmark huggingface dataset:
Traversability analysis with vision and terrain probing for safe legged robot navigation.

Inspired by human behavior when traveling over unknown terrain, this study proposes the use of probing strategies and integrates them into a traversability analysis framework to address safe navigation on unknown rough terrain.Our framework integrates collapsibility information into our existing traversability analysis, as vision and geometric information alone could be misled by unpredictable non-rigid terrains such as soft soil, bush area, or water puddles.With the new traversability analysis framework, our robot has a more comprehensive assessment of unpredictable terrain, which is critical for its safety in outdoor environments.The pipeline first identifies the terrain's geometric and semantic properties using an rgb-d camera and desired probing locations on questionable terrains.These regions are probed using a force sensor to determine the risk of terrain collapsing when the robot steps over it.This risk is formulated as a collapsibility metric, which estimates an unpredictable region's ground collapsibility.Thereafter, the collapsibility metric, together with geometric and semantic spatial data, is combined and analyzed to produce global and local traversability grid maps.These traversability grid maps tell the robot whether it is safe to step over different regions of the map.The grid maps are then utilized to generate optimal paths for the robot to safely navigate to its goal.Our approach has been successfully verified on a quadrupedal robot in both simulation and real-world experiments.

Journal: Frontiers in robotics and AI (2022)
Publication types: Journal Article
Regeneration of infarcted hearts by myocardial infarction-responsive injectable hydrogels with combined anti-apoptosis, anti-inflammatory and pro-angiogenesis properties.

Current treatments including drug therapy, medical device implantation, and organ transplantation have considerable shortcomings for myocardial infarction (mi), such as high invasiveness, the scarce number of donor organs, easy thrombosis, immune rejection, and poor therapeutic effects.Therefore, the development of new solutions to repair infarcted hearts is urgently needed.Smart responsive injectable hydrogels have served as a good foundation in biomedical engineering, especially for cardiac regeneration.Herein, we synthesized an injectable hydrogel that responds to the inflammatory microenvironment at the site of mi to provide the drug curcumin (cur) and tailored recombinant humanized collagen type iii (rh col iii) in a controlled manner for myocardial repair.The excellent antioxidant and anti-inflammatory properties of cur could effectively reduce the ros level and cell apoptosis and inhibit inflammatory reactions after mi.The tailored rh col iii promoted cell proliferation, migration, and angiogenesis.The therapeutic hydrogel resulted in the rapid recovery of cardiac function after mi by elevating the expression of the cardiac markers α-actinin and cx 43.In vitro and in vivo data showed that the combined anti-apoptosis, anti-inflammatory and pro-angiogenesis treatment strategies were an auspicious tactic for the treatment of mi, and had significant clinical application value.Furthermore, the work also demonstrated the great application potential of our tailored rh col iii in promoting the repair and regeneration of infarcted hearts.

Journal: Biomaterials (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Efficacy of single and multi-metric fish-based indices in tracking anthropogenic pressures in estuaries: An 8-year case study.

Facing a generalized increase in water degradation, several programmes have been implemented for protecting and enhancing the water quality and associated wildlife, which rely on ecological indicators to assess the degree of deviation from a pristine state.Here, single (species number, shannon-wiener h', pielou j') and multi-metric (estuarine fish assessment index, efai) community-based ecological quality measures were evaluated in a temperate estuary over an 8-year period (2005-2012), and established their relationships with an anthropogenic pressure index (api).Single metric indices were highly variable and neither concordant amongst themselves nor with the efai.The efai was the only index significantly correlated with the api, indicating that higher ecological quality was associated with lower anthropogenic pressure.Pressure scenarios were related with specific fish community composition, as a result of distinct food web complexity and nursery functioning of the estuary.Results were discussed in the scope of the implementation of water protection programmes.

Journal: Marine pollution bulletin (2015)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Rho GTPase-activating protein 35 suppresses gastric cancer metastasis by regulating cytoskeleton reorganization and epithelial-to-mesenchymal transition.

Cytoskeletal reorganization and epithelial-to-mesenchymal transition (emt) are key processes and typical characteristics of metastatic cancer cells.Rho gtpase‐activating protein 35 (arhgap35) is a gtpase-activating protein, which has a significant effect on cell motility.However, the particular function of arhgap35 in gastric cancer (gc) remains unknown.In the present study, the role of arhgap35 in gc was investigated byin vitroloss-of-function and gain-of-function experiments.Cytoskeletal reorganization in gc cells was evaluated using immunofluorescence staining and the protein expression levels of key molecules and active rho a were detected by western blot analysis.Additionally, the clinical evaluation of proteins in human gc tissues was assessed by immunohistochemistry.The results showed that arhgap35, a tumor suppressor, was downregulated in gc tissues and its decreased expression was associated with the metastatic status of gc.Additionally, transwell and wound healing assays demonstrated that arhgap35 knockdown promoted cell motilityin vitro.However, the above effects were abrogated following ectopic arhgap35 expression.Furthermore, arhgap35 could affect cytoskeletal reorganization via directly regulating rho a activation.In addition, arhgap35 upregulated e-cadherin and attenuated emt in gc cells.Both arhgap35 and e-cadherin were associated with overall survival in patients with gc, while their combination allowed for an even greater capacity for distinguishing gc patients with different prognosis.Overall, the results of the current study suggested that arhgap35 could directly regulate cell morphology and motility via affecting cytoskeletal reorganization and emt via targeting rho a and e-cadherin, respectively.Targeting the arhgap35/rho a/e-cadherin pathway could be a potential approach for treating gc.

Journal: Bioengineered (2022)
Publication types: Journal Article
DFT Fea3-O/O-O Vibrational Frequency Calculations over Catalytic Reaction Cycle States in the Dinuclear Center of CytochromecOxidase.

Density functional vibrational frequency calculations have been performed on eight geometry optimized cytochromecoxidase (cc o) dinuclear center (dnc) reaction cycle intermediates and on the oxymyoglobin (oxy mb) active site.The calculated fe-o and o-o stretching modes and their frequency shifts along the reaction cycle have been compared with the available resonance raman (r r) measurements.The calculations support the proposal that in state a[fea33+-o2-•···cu b+] of cc o, o2binds with fea32+in a similar bent end-on geometry to that in oxy mb.The calculations show that the observed 20 cm-1shift of the fea3-o stretching mode from the prto fstate is caused by the protonation of the oh-ligand on cu b2+(pr[fea34+═o2-···ho--cu b2+] →f[fea34+═o2-···h2o-cu b2+]), and that the h2o ligand is still on the cu b2+site in the r r identified f[fea34+═o2-···h2o-cu b2+] state.Further, the observed r r band at 356 cm-1between states prand fis likely an o-fea3-porphyrin bending mode.The observed 450 cm-1low fea3-o frequency mode for the ohactive oxidized state has been reproduced by our calculations on a nearly symmetrically bridged fea33+-oh-cu b2+structure with a relatively long fea3-o distance near 2 å.Based on badger's rule, the calculated fea3-o distances correlate well with the calculatedνfe-o-2/3(νfe-ois the fea3-o stretching frequency) with correlation coefficient r= 0.973.

Journal: Inorganic chemistry (2019)
Publication types: Journal Article
Effects of Ce, Sm and Yb on cavitation erosion of NAB alloy in 3.5% NaCl solution.

The influences of ce, sm and yb on cavitation erosion of nab alloy in 3.5% na cl solution are evaluated using mass loss, sem, 3d morphology and tafel plot, respectively.The results show that the addition of ce or sm or yb enhances the mechanical property of nab alloy, and the sizes of κiand κiiphases within nab alloy decrease with adding ce or sm or yb, resulting in the prevention of the propagation of the cracks caused by cavitation erosion initially originated at the phase boundaries between α and κ phases, and finally the cavitation erosion damage significantly decreases with adding ce or sm or yb.The corrosion of nab alloy in 3.5% na cl solution can promote the cavitation erosion of nab alloy, while the corrosion resistance of nab alloy increases with the addition of ce or sm or yb, and then the cavitation erosion resistance is accordingly improved with the addition of rare earth element.

Journal: Ultrasonics sonochemistry (2022)
Publication types: Journal Article
A novel peptide ADAM8 inhibitor attenuates bronchial hyperresponsiveness and Th2 cytokine mediated inflammation of murine asthmatic models.

A disintegrin and metalloproteinase 8 (adam8) has been identified as a signature gene associated with moderate and severe asthma.Studies in mice have demonstrated that the severity of asthma can be reduced by either transgenic knock-out or by antibodies blocking adam8 function, highlighting adam8 as potential drug target for asthma therapy.Here, we examined the therapeutic effect of an adam8 inhibitor peptide (bk-1361) that specifically blocks cellular adam8 activity in ovalbumin-sensitized and challenged balb/c mice.We found that bk-1361 (25 μg/g body weight) attenuated airway responsiveness to methacholine stimulation by up to 42%, concomitantly reduced tissue remodeling by 50%, and decreased inflammatory cells (e.g.Eosinophils down by 54%)/inflammatory factors (e.g.S cd23 down by 50%)/th2 cytokines (e.g.Il-5 down by 70%)/adam8-positive eosinophils (down by 60%) in the lung.We further verified that bk-1361 specifically targets adam8 in vivo as the peptide caused significantly reduced levels of soluble cd23 in wild-type but not in adam8-deficient mice.These findings suggest that bk-1361 blocks adam8-dependent asthma effects in vivo by inhibiting infiltration of eosinophils and th2 lymphocytes, thus leading to reduction of th2-mediated inflammation, tissue remodeling and bronchial hyperresponsiveness.Taken together, pharmacological adam8 inhibition appears as promising novel therapeutic strategy for the treatment of asthma.

Journal: Scientific reports (2016)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Indoor Localization Method of Personnel Movement Based on Non-Contact Electrostatic Potential Measurements.

The indoor localization of people is the key to realizing "smart city" applications, such as smart homes, elderly care, and an energy-saving grid.The localization method based on electrostatic information is a passive label-free localization technique with a better balance of localization accuracy, system power consumption, privacy protection, and environmental friendliness.However, the physical information of each actual application scenario is different, resulting in the transfer function from the human electrostatic potential to the sensor signal not being unique, thus limiting the generality of this method.Therefore, this study proposed an indoor localization method based on on-site measured electrostatic signals and symbolic regression machine learning algorithms.A remote, non-contact human electrostatic potential sensor was designed and implemented, and a prototype test system was built.Indoor localization of moving people was achieved in a 5 m × 5 m space with an 80% positioning accuracy and a median error absolute value range of 0.4-0.6 m.This method achieved on-site calibration without requiring physical information about the actual scene.It has the advantages of low computational complexity and only a small amount of training data is required.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article
Application of P4 (Predictive, Preventive, Personalized, Participatory) Approach to Occupational Medicine.

In recent years there has been a growth in the role of prevention in controlling the disease burden.Increasing efforts have been conveyed in the screening implementation and public health policies, and the spreading knowledge on risk factors reflects on major attention to health checks.Despite this, lifestyle changes are difficult to be adopted and the adherence to current public health services like screening and vaccinations remains suboptimal.Additionally, the prevalence and outcome of different chronic diseases and cancers is burdened by social disparities.P4 [predictive, preventive, personalized, participatory] medicine is the conceptualization of a new health care model, based on multidimensional data and machine-learning algorithms in order to develop public health intervention and monitoring the health status of the population with focus on wellbeing and healthy ageing.Each of the characteristics of p4 medicine is relevant to occupational medicine, and indeed the p4 approach appears to be particularly relevant to this discipline.In this review, we discuss the potential applications of p4 to occupational medicine, showing examples of its introduction on workplaces and hypothesizing its further implementation at the occupational level.

Journal: La Medicina del lavoro (2022)
Publication types: Journal Article;Review
Is an Early Age at Illness Onset in Schizophrenia Associated With Increased Genetic Susceptibility? Analysis of Data From the Nationwide Danish Twin Register.

Early age at illness onset has been viewed as an important liability marker for schizophrenia, which may be associated with an increased genetic vulnerability.A twin approach can be valuable, because it allows for the investigation of specific illness markers in individuals with a shared genetic background.Methods we linked nationwide registers to identify a cohort of twin pairs born in denmark from 1951 to 2000 (n=31,524 pairs), where one or both twins had a diagnosis in the schizophrenia spectrum.We defined two groups consisting of; n=788 twin pairs (affected with schizophrenia spectrum) and a subsample of n=448 (affected with schizophrenia).Survival analysis was applied to investigate the effect of age at illness onset.Findings we found that early age at illness onset compared to later onset in the first diagnosed twin can be considered a major risk factor for developing schizophrenia in the second twin.Additionally, we found that the stronger genetic component in mz twins compared to dz twins is manifested in the proximity of assigned diagnosis within pairs.Discussion early onset schizophrenia could be linked to a more severe genetic predisposition, indicating that age might be perceived as a clinical marker for genetic vulnerability for the illness.

Journal: EBioMedicine (2017)
Publication types: Journal Article
Influence of adolescents' tendency to catastrophise on non-suicidal self-injury behaviour: A moderated mediation model.

Adolescence is the peak period of non-suicidal self-injury (nssi) behaviour, and it is also a period when the prevention and intervention in nssi are frequently required.To explore the relationship between catastrophising and nssi and its mechanism, the mediating effects of parental support and negative emotions on catastrophising and nssi were analysed.A questionnaire was administered to 401 middle school students with a history of nssi behaviour from 12 schools in guangxi.(1) adolescents' catastrophising tendencies positively predicted their nssi status through negative emotions (b= 0.274,p< 0.001).The more severe the adolescents' catastrophising tendency, the more likely they were to have stronger negative emotions and thus show an increased nssi level.(2) parental support played a positive moderating role between the tendency to catastrophise and negative emotions (b= -0.101,t= -2.694,p< 0.01), and it had a protective effect on adolescents' nssi.Catastrophising was less likely to induce the nssi behaviour by reducing adolescents' negative emotions (b= -0.104,t= -2.313,p< 0.05); however, it should be noted that only parental affective support, informative support, and instrumental support played a significant mediating role.Parental support of adolescents has positive effects on the tendency to catastrophise, negative emotions, and nssi, and it has some implications for the prevention and intervention of adolescents' nssi.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article
Dodecaborate-Encapsulated Extracellular Vesicles with Modification of Cell-Penetrating Peptides for Enhancing Macropinocytotic Cellular Uptake and Biological Activity in Boron Neutron Capture Therapy.

Boron neutron capture therapy (bnct) is a radiation therapy for cancer.In bnct, the internalization of boron-10 atoms by cancer cells induces cell death through the generation of α particles and recoiling lithium-7 nuclei when irradiated with low-energy thermal neutrons.In this study, we aimed to construct exosomes [extracellular vesicles (evs)]-based drug delivery technology in bnct.Because of their pharmaceutical advantages, such as controlled immune responses and effective usage of cell-to-cell communication, evs are potential next-generation drug delivery carriers.In this study, we successfully developed polyhedral borane anion-encapsulated evs with modification of hexadeca oligoarginine, which is a cell-penetrating peptide, on the ev membrane to induce the actin-dependent endocytosis pathway, macropinocytosis, which leads to efficient cellular uptake and remarkable cancer cell-killing bnct activity.The simple and innovative technology of the ev-based delivery system with "cassette" modification of functional peptides will be applicable not only for bnct but also for a wide variety of therapeutic methodologies.

Journal: Molecular pharmaceutics (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Insights into Mechanism of Aβ42Fibril Growth on Surface of Graphene Oxides: Oxidative Degree Matters.

The filamentous β-amyloid deposition has been regarded as the hallmark pathology of alzheimer's disease (ad).Nanomaterials such as graphene oxides (gos) have achieved significant progress in the therapy of ad, but the molecular pathway of the growth propagation remains challenging to investigate, especially on the surfaces of materials.The thermodynamics and kinetics of fibril elongation on go surfaces with different oxidative degrees have been investigated by a combination of in vitro experiments and simulations.Th t kinetics, calorimetric measurements, and tem observations suggest that low oxidative go-10 promotes the fibril elongation, while both high oxidative go-20 and go-40 inhibit the fibril elongation.Computational results reveal that the apparent regulation behaviors of gos on filament growth depend on the balance between the promoting effect by templating the incoming of monomers and the retarding effect by capturing the monomer during docking and locking phases through hydrogen bonding.This work will promote the understanding of the interplay between biomolecules and materials, thus providing new thoughts for the rational design of novel materials for amyloidosis therapy.

Journal: Advanced healthcare materials (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Utility of thromboelastogram in cardiac surgery in Jacobsen syndrome associated with platelet dysfunction: a case report.

Jacobsen syndrome is a rare genetic disorder with multiple congenital anomalies and platelet abnormalities caused by chromosome 11 deletion.Case presentation a 7-month-old boy with thrombocytopenia underwent ventricular septal defect closure.At the beginning of surgery, the platelet count was 168 × 103/μl, and heparinized kaolin with heparinase reaction time (hkh-r), which represents clot formation time, was prolonged at 30.4 min.Platelet transfusion was continued, and at the end of surgery, the platelet count and hkh-r values improved to 215 × 103/μl and 15 min, respectively.Conclusions as anesthetic management of patients with abnormal platelet function, the viscoelasticity test might be useful in evaluating hemostatic capacity.

Journal: JA clinical reports (2022)
Publication types: Journal Article
Medical students' acceptance and perceptions of e-learning during the Covid-19 closure time in King Abdulaziz University, Jeddah.

Nowadays, there is a paradigm shift in medical education.This shift occurred following the covid-19 crisis.The world uses digital e-learning to support the public health response to this pandemic.The study's objective was to determine the medical students' acceptance and perceptions of e-learning during the covid-19 closure time in jeddah.Methods a cross-sectional, web-based study was done among 340 medical students from king abdulaziz university, 2020.A standardized, electronic, self-administered, google form data collection sheet was distributed.It included the e-learning acceptance measure (el am) containing three constructs, namely: tutor quality (tq), perceived usefulness (pu), and facilitating conditions (fc).The sheet also inquired about the students' perceptions of the benefits, enablers, and barriers to e-learning.Descriptive, inferential statistics and multiple linear regression analyses were applied.Results blackboard and zoom were the most preferred learning management systems (lms) by our medical students.The mean score of el am was 102.82 ± 24.102.Better achievers obtained significantly (p < 0.001) higher scores in all el am constructs.About three-fifths of the students confirmed that e-learning substituted classical on-campus learning and was an adaptable, and less time-consuming method.The educator's good e-learning skills, the subject, instructional design, interaction, motivation, and good lms were agreed as enablers of e-learning.However, most students accepted that clinical teaching is the most challenging learning outcome and that exams could be affected by low internet quality.Conclusion medical students moderately accepted e-learning during the covid-19 pandemic closure time.More training of the students and tutors, better designing e-courses, more interaction, motivation, and blended learning are recommended.

Journal: Journal of infection and public health (2021)
Publication types: Journal Article