syedzayyan/paper_mill_benchmark huggingface dataset:
Clinical Observation of General Anesthesia Combined with Spinal Anesthesia in Elderly Patients with Chronic Obstructive Pulmonary Disease

This work is aimed at evaluating the efficacy and safety of general anesthesia (ga) combined with spinal anesthesia (sa) (ga+sa) in elderly patients with chronic obstructive pulmonary disease (copd).Methods and material .50 elderly copd patients were rolled randomly into a control group (simple ga) and observation group (ga+sa).The differences in operation time, postoperative recovery time (prt), language expression time (let), anesthetic dosage (ad), catheter extubation time (cet), respiratory circulation indicators (mean arterial pressure (map), heart rate (hr), sa o 2 , and pa o 2 ), postoperative vrs score, pulmonary function (forced vital capacity (fvc)), forced expiratory volume in 1 s (fev1)/fvc and forced expiratory flow (fef 25%~75%), serum inflammatory factors (il‐6, il‐8, and tnf‐ α ), short portable mental status questionnaire (spmsq) score, and the incidence of respiratory system events were analyzed.Results .The results showed that the prt, let, ad, and cet of the observation group were all shorter ( p &lt; 0.05).The postoperative map, hr, sa o 2 , and pa o 2 levels of patients who received ga+sa were much higher than those who received simple ga ( p &lt; 0.05).The postoperative vrs score of the observation group was better than that of the controls ( p &lt; 0.05).The postoperative pulmonary function of patients in the observation group was better compared with that in the control group ( p &lt; 0.05).The postoperative serum inflammatory factors in the observation group were lower in contrast to the patients who received simple ga ( p &lt; 0.05).The postoperative cognitive function spmsq score of patients who received ga+sa was lower compared with the score of patients who received simple ga ( p &lt; 0.05).However, the probability of respiratory system events in the observation group was lower ( p &lt; 0.05).Conclusion .In conclusion, ga+sa could significantly shorten the prt and improve the recovery quality of elderly copd patients.It can also reduce the postoperative inflammatory response and strengthen the pulmonary function and cognitive function.It also enhances the analgesic which is beneficial to patients’ postoperative recovery.Therefore, ga+sa was a highly effective and safe anesthesia method for elderly patients with copd, and it was worthy of clinical application.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Assessment of Bacterial Isolates from the Urine Specimens of Urinary Tract Infected Patient

Urinary tract infections (utis) maintained a serious public health concern, as did the growth in antibiotic resistance both between uropathogenic microorganisms.A regular assessment of the microbiological agents that cause utis, as well as their antimicrobial resistance, is essential for a tailored empirical antibiotic response.Knowing the variables that cause utis can help you intervene quickly and simply to get the condition under control.The most common infecting species in acute infection is escherichia coli (e.Coli).To strengthen infection control strategies, it is necessary to know the prevalence and location of uti.The goal of this research is to measure the frequency of microorganisms isolated from patients with utis as well as the antimicrobial sensitivity characteristics of gram‐negative bacteria.The purpose of this research has been to evaluate the frequency of utis by extracting and characterizing the various bacterial etiological organisms, as well as to assess the factors linked to utis.The goal of this research is to identify, characterize, and establish the antibiotic susceptibility patterns of bacteria linked to urinary tract infections.Fresh collected urine specimen was taken from inpatients or outpatients in uti cases and bacteriologically tested using conventional microbiological methods.The kirby‐bauer disc diffusion method was used to create the antibiogram.Staphylococcus saprophyticus, staphylococcus aureus (28%), and escherichia coli (24.6%) were the most common isolates (20%).The evaluated agents’ antibacterial activity was all in the following order: cefixime, ciprofloxacin, augmentin, gentamicin, ceftazidime, nitrofurantoin, ofloxacin, and cefuroxime.It was discovered that each and every one of the microbes exhibited varied degrees of resistance to the antibiotics nitrofurantoin, ciprofloxacin, and ofloxacin.Every type of bacteria, with the exception of those belonging to the genus streptococcus, has a multiple antibiotic resistance index (mari) that is more than 0.2.The first‐line therapies for urinary tract infections (utis) in the region would consist of ciprofloxacin, ofloxacin, and nitrofurantoin.Lower urinary tract infections almost never result in problems if they are diagnosed and treated as soon as possible and in the correct manner.However, if treatment is not sought, a urinary tract infection can lead to serious complications.

Journal: BioMed Research International (2022)
Publication types: Research Article;
CNN-Based Cross-Modal Residual Network for Image Synthesis

This study attempts to address the issue that present cross‐modal image synthesis algorithms do not capture the spatial and structural information of human tissues effectively.As a consequence, the resulting photos include flaws including fuzzy edges and a poor signal‐to‐noise ratio.The authors offer a cross‐sectional technique that combines residual modules with generative adversarial networks.The approach incorporates an enhanced residual initial module and attention mechanism into the generator network, reducing the number of parameters and improving the generator’s feature learning capabilities.To boost discriminant performance, the discriminator employs a multiscale discriminator.A multilevel structural similarity loss is included in the loss function to improve picture contrast preservation.On the adni data set, the algorithm is compared to the mainstream algorithms.The experimental findings reveal that the synthetic pet image’s mae index has dropped while the ssim and psnr indexes have improved.The experimental findings suggest that the proposed model may maintain picture structural information while improving image quality in both visual and objective measures.The residue initial module and attention mechanism are employed to increase the generator’s capacity for learning, while the multiscale discriminator is utilized to improve the model’s discriminative performance.The enhanced method in this study can maintain the structure and contrast information of the picture, according to comparative experimental findings using the adni dataset.The produced picture is hence more aesthetically similar to the genuine print.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Analysis of Painting Elements of Tea Culture and Art Works Based on Image Perception

The art works take tea as the theme of painting elements, and depict the content of chinese traditional culture by showing the connotation of tea culture painting elements.For example, wen zhiming, a painter and calligrapher in ming dynasty, is best at painting landscape figures.He often uses tea as the theme in his art works, adding the elegant, natural, and simple painting elements of tea into his works, and has created many famous art works that are spread around the world.In recent years, with the deepening of the research on image processing technology, image perception technology has attracted more and more researchers’ attention, which has made great achievements and progress in image perception algorithms.This paper studies the tea culture elements of art works based on image perception algorithm.The accuracy of similar image pairs is the ratio that similar image pairs are correctly recognized.When the number of experiments reaches 25, the image sensing algorithm in this paper has the highest accuracy rate, with the accuracy rate of 99.8%, when the number of experiments reaches 20, the ant colony algorithm with the accuracy rate of 96.5%, when the number of experiments reaches 20, and finally the artificial intelligence algorithm with the accuracy rate of 96.0%.The correct rate of similar image pairs is the correct recognition rate of tampered image pairs.When the number of experiments reaches 10 times, the correct rate of image perception algorithm in this paper still ranks first, with the correct rate of 99.8%, when the number of experiments reaches 25 times, the artificial intelligence algorithm with the correct rate of 98.2%, and finally when the number of experiments reaches 10 times, the ant colony algorithm with the correct rate of 96.2%.It can be seen that the numerical values in this column show the robustness of this algorithm.Through the cultivation of students’ image perception ability, it can promote students’ appreciation ability of tea culture painting elements, learn the knowledge of tea culture painting elements beauty in a deeper level, master the skills of beauty, and improve their artistic temperament and artistic accomplishment.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;
Long Noncoding RNA WDFY3-AS2 Suppresses Tumor Progression by Acting As a Competing Endogenous RNA of MicroRNA-18a in Ovarian Cancer

Ovarian cancer (oc) is a fatal cancer in women, mainly due to its aggressive nature and poor survival rate.The lnc rna‐mi rna‐m rna (long noncoding rna‐micro rna‐messenger rna) interaction is promising biomarkers for the improving prognosis of oc.Therefore, we explored the regulatory mechanism of wdfy3‐as2/mi r‐18a/rora axis involved in the biological activities of oc cells.Microarray analysis predicted differentially expressed lnc rna, mi rna, and m rna related to oc, followed by investigating the relationship among them.The expression patterns of the identified lnc rna wdfy3‐as2, mi r‐18a, and rora were measured in oc tissue and cells.Gain‐ and loss‐of‐function experiments were performed to characterize the effect of lnc rna wdfy3‐as2 on oc cells, as well as the involvement of mi r‐18a and rar related orphan receptor a (rora).The in vitro assays were validated by in vivo experiments.According to bioinformatics analysis, wdfy3‐as2 was speculated to affect oc by sponging mi r‐18a and modulating rora.Wdfy3‐as2 and rora were underexpressed in oc, while mi r‐18a was highly expressed.Notably, wdfy3‐as2 acts as a competing endogenous rna to sponge mi r‐18a and upregulate rora.Upon overexpressing wdfy3‐as2 or inhibiting mi r‐18a, rora expression was increased, thereby the oc cell proliferation, migration, invasion, and epithelial‐to‐mesenchymal transition (emt) were suppressed, accompanied by enhanced apoptosis.In vivo experiments confirmed that the tumor growth was reduced in response to overexpressed wdfy3‐as2 or inhibited mi r‐18a.Taken together, the lnc rna wdfy3‐as2/mi r‐18a axis regulates the tumor progression of oc by targeting rora, providing new insights for prevention and control of oc.

Journal: Journal of Cellular Physiology (2019)
Publication types: Research Article;
Ameliorated Stomach Specific Floating Microspheres for Emerging Health Pathologies Using Polymeric Konjac Glucomannan-Based Domperidone

The goal of this study was to use polymeric konjac glucomannan (kgm), kollidon va 64 (kva64), and glutaraldehyde to ameliorate stomach specific floating microspheres (ssfm) using domperidone (do n) to increase in vivo bioavailability and emerging health pathologies.The ssfm were made using the emulsion cross‐linking process, and the polymer was chosen based on its ability to get cross‐linked.The thermodynamic parameters were used to determine the a l classes of phase solubility curves using ideal complexes produced with kva64.The optimal interaction constants at 25 and 37°c were found to be 116.14 and 128.05 m -1 , respectively.The prepared ssfm had an average particle size (ps) of 163.71 ± 2.26 mm and a drug content of 96.66 ± 0.32%.It can be determined from in vitro drug release experiments that drug release is good in terms of regulated drug release after 12 h (92.62 ± 2.43%).The ssfms were approximately sphere‐shaped and had smooth surfaces, according to the morphological data.Ssfms were investigated using fourier transform infrared (ft‐ir) spectroscopy, x‐ray diffraction (xrd), and differential scanning calorimetry (dsc), and no chemical structural changes were identified.The ssfms produces a considerable gastric residence time with optimal do n release and absorption in stomach fluid, and the mean residence time (17.36 ± 1.4 h) and t 1/2 (10.47 ± 0.6 h) were considerably longer ( p &lt; 0.05) than those obtained following i.v.Treatment (mrt = 8.42 ± 1.2 h; t 1/2 = 9.07 ± 0.7 h).The ssfms maintained good physical stability for three months when stored at room temperature.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Affective Antidepressant, Cytotoxic Activities, and Characterization of Phyto-Assisted Zinc Oxide Nanoparticles Synthesized Using Sanvitalia procumbens Aqueous Extract

Green synthesis of nanoparticles has emerged as an effective and environmentally friendly method.Therefore, the current investigation is based on the green synthesis of zinc oxide nanoparticles (zn o‐nps) using plant extract of sanvitalia procumbens ( s.Procumbens ) that act as a capping and reducing agent.S.Procumbens is a fast‐growing shrub and densely available plant and may have potential to synthesize zn o‐nps.The synthesized zn o‐nps were characterized by different techniques, including fourier transform infrared spectroscopy (ft‐ir), uv‐visible (uv‐vis), energy‐dispersive x‐ray (edx), x‐ray diffraction (xrd), and scanning electron microscopy (sem).The uv‐vis spectrum at 350 nm revealed an absorption peak for the synthesis of zn o‐nps.In addition, photoactive biomolecules of the prepared zn o‐nps were identified by using ft‐ir spectroscopy.Furthermore, the spherical geometry of zn o‐nps was evaluated by sem images.The synthesized zn o‐nps were also used to enhance the antidepressant activity and exhibited a remarkable reduction in the time of immobility in tail suspension tests (tst) and forced swim tests (fst), as well as increased the bdnf levels in the brain and plasma.Zn o‐nps have a low risk of biocompatibility (cell visibility) at a concentration of 7 g/m l or below.The nanoparticles were biologically compatible when the concentrations were increased up to 11 μ g/m l.It was concluded that zn o‐nps were investigated as a possible carrier for antidepressant drug delivery into the brain, and their excellent cytotoxic activity was evaluated by using the mtt assay to determine their biocompatibility.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Adoption of Dexmedetomidine in Different Doses at Different Timing in Perioperative Patients

Dexmedetomidine (dex) is an alpha‐2 agonist used for sedation during various procedures.Dex activates 2‐adrenoceptors, and causes the decrease of sympathetic tone, with attenuation of the neuroendocrine and hemodynamic responses to anesthesia and surgery; it reduces anesthetic and opioid requirements; and causes sedation and analgesia.Objective: it was to compare the perioperative effects of different doses of dex at different timing in patients using dex during the perioperative period adopting a medical data classification algorithm based on optimized semi‐supervised collaborative training (tri‐training).Methods: 495 patients requiring surgical treatment in xingtai people’s hospital were randomly selected as the study subjects.The patients were divided into group a (used before induction), group b (used during induction), and group c (used after induction) according to different induction timing, with 165 cases in each group.Then, groups a, b, and c were divided into groups a1, b1, and c1 (0.4 μ g/(kg·h) rate), groups a2, b2, and c2 (0.6 μ g/(kg·h) rate), and groups a3, b3, and c3 (0.8 μ g/(kg·h) rate) according to the dose used, with 55 cases in each group.Intraoperative anesthesia and postoperative adverse reactions were compared among the 9 groups.Results: the similarity between the tri‐training algorithm optimized by naive bayes (nb) classification algorithm and the actual classification (93.49%) was clearly higher than that by decision tree (dt) and k‐nearest neighbor (k nn) classification algorithm (76.21%, 74.31%); heart rate (hr), systolic blood pressure (sbp), and diastolic blood pressure (dbp) values decreased obviously after dex used in groups b1, c1, b2, c2, b3, and c3 ( p &lt;0.05 ), but did not change significantly in groups a1, a2, and a3 ( p &gt;0.05 ); the proportion of patients with satisfactory ramsay score in group a3 was distinctly superior than that in groups a1, a2, b1, b2, b3, c1, c2, and c3 ( p &lt;0.05 ); the incidence of adverse reactions in group a3 was significantly inferior than that in groups a1, a2, b1, b2, b3, c1, c2, and c3 ( p &lt;0.05 ).Conclusion: the optimization effect of nb classification algorithm was the best, and the injection of dex at the injection rate of 0.8 μ g/(kg·h) before induction of anesthesia could apparently improve the fluctuation of hr, sbp, and dbp during perioperative period, and effectively reduce the occurrence of adverse reactions in patients, with better sedative effect on patients.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Acetylshikonin, A Novel CYP2J2 Inhibitor, Induces Apoptosis in RCC Cells via FOXO3 Activation and ROS Elevation

Acetylshikonin is a shikonin derivative originated from lithospermum erythrorhizon roots that exhibits various biological activities, including granulation tissue formation, promotion of inflammatory effects, and inhibition of angiogenesis.The anticancer effect of acetylshikonin was also investigated in several cancer cells; however, the effect against renal cell carcinoma (rcc) have not yet been studied.In this study, we aimed to investigate the anticarcinogenic mechanism of acetylshikonin in a498 and achn, human rcc cell lines.Mtt (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), cell counting, and colony forming assay showed that acetylshikonin induced cytotoxic and antiproliferative effects in a dose- and time-dependent manner.Cell cycle analysis and annexin v/propidium iodide (pi) double staining assay indicated the increase of sub g1 phase and apoptotic rates.Also, dna fragmentation was observed by using the tunel and comet assays.The intracellular ros level in acetylshikonin-treated rcc was evaluated using dcf-da.The ros level was increased and cell viability was decreased in a dose- and time-dependent manner, while those were recovered when cotreated with nac.Western blotting analysis showed that acetylshikonin treatment increased the expression of foxo3, cleaved parp, cleaved caspase-3, -6, -7, -8, -9, γh2ax, bim, bax, p21, and p27 while decreased the expressions of cyp2j2, peroxiredoxin, and thioredoxin-1, bcl-2, and bcl-x l.Simultaneously, nuclear translocation of foxo3 and p27 was observed in cytoplasmic and nuclear fractionated western blot analysis.Acetylshikonin was formerly identified as a novel inhibitor of cyp2j2 protein in our previous study and it was evaluated that cyp2j2 was downregulated in acetylshikonin-treated rcc.Cyp2j2 si rna transfection augmented that apoptotic effect of acetylshikonin in a498 and achn via up-regulation of foxo3 expression.In conclusion, we showed that the apoptotic potential of acetylshikonin against rcc is mediated via increase of intracellular ros level, activation of foxo3, and inhibition of cyp2j2 expressions.This study offers that acetylshikonin may be a considerable alternative therapeutic option for rcc treatment by targeting foxo3 and cyp2j2.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
A Study on Curcumol Influencing Proliferation and Apoptosis of Hepatocellular Carcinoma Cells through DJ-1/PTEN/PI3K/AKT Pathway

To study the mechanism of curcumol affecting the proliferation and apoptosis of liver cancer cells through the dj‐1/pten/pi3k/akt pathway.Method .Hep g2 cells were cultured in vitro, treated with curcumol at concentrations of 10, 30, and 100 μ g/m l, and dmso was used as a control.The levels of cell proliferation and apoptosis were measured by cck‐8 and flow cytometry, respectively.Rt‐pcr and western blot were used to detect pten, p‐akt, dj‐1, and pi3k gene and protein expression changes.Result .(1) compared with the dmso blank control group, the proliferation level of liver cancer cells in the 10 μ g/m l curcumol group decreased, and the proportion of apoptosis increased (p &lt;0.05).(2) compared with the blank control group and the 10 and 30 μ g/m l concentration groups, the proliferation level of liver cancer cells in the 100 μ g/m l curcumol group was significantly reduced, and the proportion of cell apoptosis was significantly increased ( p &lt; 0.05).(3) curcumol can significantly increase the expression of pten gene and protein in liver cancer cells and reduce the expression of dj‐1 and pi3k genes and protein in liver cancer cells ( p &lt; 0.05).Conclusion .Curcumol can regulate dj‐1, pten, pi3k, and akt signal transduction pathways, inhibit cell proliferation, and cause a significant increase in the proportion of cell apoptosis, and the pharmacodynamic effect of curcumol is dependent on the time and dose of action.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Application of User Experience Gene Extraction Model Based on Industrial Design

Product design dna is a new concept produced by applying the idea of genetic engineering to the field of industrial design, involving multiple knowledge fields, aiming to give products a unique shape and style image to build a brand.This paper systematically summarizes the current situation and progress of product design dna research at home and abroad, focusing on the expression structure, application research progress, and research on key technologies.The law of dna generation and derivation; explore the user’s cognitive mechanism for product design dna; realize the connection between product design dna reasoning and production.The designed user experience gene extraction based on industrial design provides new ideas for product design and has strong guiding significance.

Journal: Security and Communication Networks (2022)
Publication types: Research Article;