syedzayyan/paper_mill_benchmark huggingface dataset:
Clinical Practice of Cataract Special Care Standards in Nonophthalmic Wards

Cataract is a lens metabolism disease, which is caused by various factors, and leads to metamorphic lens proteins turbidity.Cataract commonly occurs in elderly patients, and majority of these patients have clinical manifestations of blurred vision and other symptoms.In this study, we explored the clinical practice and observations of cataract care criteria in nonophthalmic wards.To realize this, a total of one hundred and twenty (120) cataract patients, admitted to the east department of ophthalmology, shanghai sixth people’s hospital, particularly from april 2019-2020, were divided into the control and observation groups, where 60 cases were added to each group.The control group received routine nursing, and observation group was treated with cataract care criteria based on the control group.The complication rate, health cognition, and patient’s satisfaction were compared with existing approaches.The incidence of corneal edema, anterior chamber hemorrhage, endophthalmitis, and incision infection, specifically in the observation group, was lower than that in the control group ( p &lt; 0.05 ).Likewise, the number of hospitalization days and expenses, specifically in the observation group, were lower than those in the control group ( p &lt; 0.05 ).Health knowledge and satisfaction scores of the observation group were higher than the control group ( p &lt; 0.05 ).Active service, service attitude, psychological support, caring patients, and health education dissatisfaction rate of the observation group were lower than the control group ( p &lt; 0.05 ).Finally, the standard of cataract care in nonophthalmic wards reduces the incidence of complications, improve health awareness of patients, and help to improve satisfaction of patients with nurses.Furthermore, it is worthy of promotion and application particularly in traditional hospitals.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Clinical Study;
Clinical Observation on the Treatment of Rotator Cuff Injury with Modified Buyang Huanwu Decoction and Rotator Cuff Repair

In this paper, we have evaluated the clinical efficacy of rotator cuff surgery combined with chinese medicine buyang huanwu decoction (adding medicine) in the treatment of patients with rotator cuff injury.For this purpose, sixty patients with rotator cuff injury and shoulder arthroscopic surgery were selected in this hospital (where 57 cases were finally screened).The patients were divided into a control group (28 cases) and a study group (29 cases) by the envelope method.The control group received conventional treatment after the operation, whereas the study group was combined with buyang huanwu decoction after the operation.The clinical efficacy of the two groups, particularly after treatment, was compared in terms of self-care ability and constant–murley scores before and after treatment, that is, 4 w, 8 w, and 12 w.The total effective rate of treatment in the study group was significantly higher than that of the control group after 4 weeks of treatment ( p &lt; 0.05 ).There was no significant difference in the fim self-care scores of the two groups before treatment ( p &gt; 0.05 ).In the study group patients, after treatment for 4 w and 8 w, the fim self-care score was significantly improved ( p &lt; 0.05 ).The fim self-care score of the patients in the study group, after 12 w of treatment, had no significant difference compared with the control group ( p &gt; 0.05 ).The constant–murley scores of the two groups were compared before treatment where no significant difference is observed ( p &gt; 0.05 ) and the constant–murley score of the study group patients was significantly higher than that of the control group, after 4 w and 8 w treatment ( p &lt; 0.05 ).Additionally, constant–murley score of the study group was not significantly higher than that of the control group after 12 w of treatment difference ( p &gt; 0.05 ).The proposed combined treatment program has value of promotion and implementation in the clinical treatment of patients with rotator cuff injury.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Clinical Observation of Alternative Wave Electroacupuncture Combined with Lee’s Naprapathy in Treating Knee Osteoarthritis (Blood Stasis due to Qi Stagnation)

We aim to explore the clinical therapeutic effect of alternative wave electroacupuncture combined with lee’s naprapathy therapy on knee osteoarthritis (koa) (blood stasis due to qi stagnation).Method.122 patients with koa treated in our hospital from january 2018 to october 2021 were randomly grouped into a combined group (n = 61) and a control group (n = 61).The combined group was treated with alternative wave electroacupuncture combined with lee’s naprapathy, while the control group was treated with alternative wave electroacupuncture alone.Clinical efficacy of the two groups was observed.The visual analogue scale (vas), lysholm scale, indexes of severity for osteoarthritis (isoa), and western ontario and mc master universities osteoarthritis index (womac) were compared before and after treatment, followed up for 3 months and 6 months.The adverse reactions of the two groups were observed.Result.The overall response rate of the combined group (96.72%) was higher than that of the control group (81.97%), and the difference was statistically significant ( p &lt; 0.05 ).After treatment and follow-up for 3 months and 6 months, the lysholm score of the combined group was higher than that of the control group, while the vas, isoa, and womac scores were lower than those of the control group, and the difference between the two was statistically significant ( p &lt; 0.05 ).There were no serious adverse reactions in both groups ( p &gt; 0.05 ).Conclusion.The alternative wave electroacupuncture combined with lee’s naprapathy is effective and safe in treating koa (blood stasis due to qi stagnation).

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Clinical Efficacy of Levothyroxine Sodium plus I 131 in the Treatment of Patients with Thyroidectomy and Its Effect on the Levels of Thyroglobulin and Thyrotropin

This study was to evaluate the clinical efficacy of levothyroxine sodium tablets combined with i 131 in the treatment of patients after thyroidectomy and the effect on thyroglobulin (tg) and thyroid stimulating hormone (tsh) levels.Methods.80 patients with differentiated thyroid cancer who required thyroidectomy after surgery between july 2019 and january 2021 were recruited for prospective study, 40 patients in the control group received levothyroxine sodium tablets, and 40 patients in the experimental group received levothyroxine sodium treatment plus i 131 treatment.Treatment effect, serum tg and tsh levels, and relapse were measured.Results.The removal rate of residual thyroid tissue in the experimental group (87.50%) was significantly higher than that in the control group (57.50%) ( p &lt; 0.05 ).Levothyroxine sodium tablets plus i 131 was associated with a significantly higher efficacy versus levothyroxine sodium tablets ( p &lt; 0.05 ).There were no significant differences in the serum tg levels between the two groups before treatment ( p &gt; 0.05 ).After treatment, the serum tg levels in both groups were significantly decreased, and levothyroxine sodium tablets plus i 131 resulted in a significantly lower tg level versus levothyroxine sodium tablets ( p &lt; 0.05 ).Before treatment, the two groups showed similar tsh levels ( p &gt; 0.05 ).After treatment, patients receiving levothyroxine sodium tablets plus i 131 had a significantly greater increase in the tsh levels versus levothyroxine sodium tablets ( p &lt; 0.05 ).The recurrence rate of the experimental group was lower than that of the control group ( p &lt; 0.05 ).Conclusion.Levothyroxine sodium tablets plus i 131 for post-operative patients with differentiated thyroid cancer enhance the removal rate of residual thyroid tissue, effectively reduce serum tg level, and increase tsh level, with significant therapeutic effects, low recurrence rates, and a high safety profile.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Clinical Efficacy of Laparoscopic Billroth II Subtotal Gastrectomy Plus Lienal Polypeptide Injection for Gastric Cancer

To evaluate the clinical efficacy of laparoscopic billroth ii subtotal gastrectomy plus lienal polypeptide injection for gastric cancer.Methods.Between may 2018 and january 2021, 110 patients with gastric cancer treated in jingzhou first people’s hospital were recruited and assigned via the random number table method to either an observation group or a control group, with 55 patients in each group.All patients received laparoscopic billroth ii subtotal gastrectomy, and the observation group additionally received lienal polypeptide injection.Outcome measures include surgical indexes, clinical efficacy, and adverse events.Results.The patients in the observation group had significantly less intraoperative hemorrhage volume, smaller surgical wounds, shorter time lapse before passing gas and hospital stay, and longer operation time than those in the control group ( p &lt; 0.001 ).The observation group showed significantly higher efficacy than the control group ( p = 0.001 ).The observation group had a significantly lower incidence of toxic side effects and adverse events than the control group ( p &lt; 0.05 ).After treatment, the cd3+ and cd4+ levels were significantly elevated and the cd8+ level was decreased, with higher cd3+ and cd4+ levels and lower cd8+ levels in the observation group than in the control group ( p &lt; 0.05 ).Conclusion.In the treatment of patients with gastric cancer, laparoscopic billroth ii subtotal gastrectomy plus lienal polypeptide injection features promising efficacy, improves the immune function of patients, effectively reduces the occurrence of toxic side effects and adverse reactions, with less trauma and rapid recovery, which shows good potential for use in clinical application.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Clinical Effects of Acupuncture for Stroke Patients Recovery

Stroke is assumed as one of the common cerebrovascular diseases that endangers human health and life.Its incidence and mortality rates are high, while survivors (50% to 70%) suffer from different degrees of disability.Hemiplegia is a common disability after stroke, mainly manifested as muscle weakness of the affected side, limb spasm, and limited activity, which severely impacts a patient’s daily life.There are various rehabilitation methods for stroke hemiplegia, including modern rehabilitation medicine, motor therapy, acupuncture, and rehabilitation robot.The cost and effect of different rehabilitation methods are not the same.It is the focus to find an economical and effective rehabilitation method.In this paper, 128 stroke patients aged 41 to 73 hospitalized between january 2019 and january 2021 were analyzed.The intervention group used standard physical therapy and traditional acupuncture therapy, and the control group only used standard physical therapy.We used rstudio 1.1.419 (rstudio corporation) for analysis.Experimental results show that the short-term efficacy of the intervention group is better than that of the control group.The intervention group was better than the control group in recovery from injury during rehabilitation, degree of muscle spasm, self-care ability in daily life, and overall degree of damage.In the long-term efficacy analysis, we can see that with the increase in the number of acupuncture, the efficacy of the intervention group is still better than that of the control group.Compared with physical rehabilitation alone, acupuncture has better short-term, and long-term clinical effects for stroke patients improves motor dysfunction and improves the quality of life and independence of stroke patients.With the increase in the number of acupuncture treatments, the patient’s rehabilitation effect will be better.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Clinical Effect and Postoperative Pain of Laparo-Thoracoscopic Esophagectomy in Patients with Esophageal Cancer

To investigate the clinical effect and postoperative pain of laparo-thoracoscopic esophagectomy in patients with esophageal cancer.Methods.A total of 90 patients with esophageal cancer who were admitted and treated in our hospital from august 2020 to november 2021 were randomly selected as the research subjects for prospective analysis, and the patients were assigned to the control group and the experimental group according to the time of admission equally, with 45 cases in each group.Patients in the control group underwent conventional open surgery, and those in the experimental group underwent laparo-thoracoscopic esophagectomy.Then, operation-related indicators, postoperative pain, inflammatory factors, and complications were compared between the two groups.Results.The operation time, intraoperative blood loss, postoperative drainage, and postoperative length of stays of the experimental group were significantly shorter or less than those of the control group ( p &lt; 0.05 ); there was no significant difference in the number of lymph nodes dissected between the two groups ( p &gt; 0.05 ).The number of patients with moderate and severe pain in the experimental group was significantly smaller than that in the control group, and the number of patients with mild pain was significantly larger than that in the control group ( p &lt; 0.05 ).The level of inflammatory factors (tnf-α, il-6, il-8, and il-10) was significantly lower than that in the control group ( p &lt; 0.05 ); the incidence of surgical complications in the experimental group was significantly lower than that in the control group ( p &lt; 0.05 ).Conclusion.Laparo-thoracoscopic esophagectomy can significantly improve the clinical effect in patients with esophageal cancer.Thoracic-laparoscopic esophagectomy can significantly improve the clinical results of patients with esophageal cancer.With better performance in surgery-related indicators, lower inflammatory factor levels and postoperative pain, and fewer postoperative complications, it will speed up patients’ recovery and is worthy of clinical promotion and application.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Clinical Application of Early Warning Scoring Based on BiLSTM-Attention in Emergency Obstetric Preexamination and Triage

Maternity is a special category of population and the criteria for emergency prescreening cannot be directly applied to adults.Therefore, a set of criteria for grading maternal conditions should be established.In this paper, we have combined the semantic analysis technique of bi lstm-attention neural network and fuzzy defect risk assessment method, to develop a hybrid approach, to preprocess the text of emergency obstetric prescreening information.Furthermore, we have used word2vec to characterize the word embedding vector and highlight the features related to the degree of defects of emergency obstetric prescreening information through the attention mechanism and obtain the semantic feature vector of the warning information.Bi lstm-attention neural network has the dual advantages of extracting bidirectional semantic information and giving weight to important judgment information which has effectively improved the semantic understanding accuracy.Experimental tests and application analysis show that the judgment model which is based on proposed method has accurately classified and graded the defects of emergency obstetric prescreening alerts.Additionally, the accuracy and microaverage value are used as evaluation indexes.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Breast Cancer Cells Metastasize to the Tissue-Engineered Premetastatic Niche by Using an Osteoid-Formed Polycaprolactone/Nanohydroxyapatite Scaffold

It has been deemed that the premetastatic niche (pmn) plays a critical role in facilitating bone metastasis of breast cancer cells.Tissue engineering scaffolds provide an advantageous environment to promote osteogenesis that may mimic the bony premetastatic niches (bpmns).In this study, human mesenchymal stem cells (h mscs) were seeded onto designed polycaprolactone/nanohydroxyapatite (pcl-n ha) scaffolds for osteogenic differentiation.Subsequently, a coculture system was used to establish the tissue-engineered bpmns by culturing breast cancer cells, h mscs, and osteoid-formed pcl-n ha scaffolds.Afterwards, a migration assay was used to investigate the recruitment of mda-mb-231, mcf-7, and mda-mb-453 cells to the bpmns’ supernatants.The cancer stem cell (csc) properties of these migrated cells were investigated by flow cytometry.Our results showed that the m rna expression levels of alkaline phosphatase (alp), osterix, runt-related transcription factor 2 (runx2), and collagen type i alpha 1 (col1a1) on the pcl-n ha scaffolds were dramatically increased compared to the pcl scaffolds on days 11, 18, and 32.The expression of cxcl12 in these bpmns was increased gradually over coculturing time, and it may be a feasible marker for bpmns.Furthermore, migration analysis results showed that the higher maturation of bpmns collectively contributed to the creation of a more favorable niched site for the cancerous invasion.The subpopulation of breast cancer stem cells (bcscs) was more likely to migrate to fertile bpmns.The proportion of bcscs in metastatic mda-mb-231, mcf-7, and mda-mb-453 cells were increased by approximately 63.47%, 149.48%, and 127.60%.The current study demonstrated that a designed tissue engineering scaffold can provide a novel method to create a bone-mimicking environment that serves as a useable platform to recapitulate the bpmns and help interrogate the scheme of bone metastasis by breast cancer.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
Bioinorganic Synthesis of Polyrhodanine Stabilized Fe3O4//Graphene Oxide in Microbial Supernatant Media for Anticancer and Antibacterial Applications

Polyrhodanines have been broadly utilized in diverse fields due to their attractive features.The effect of polyrhodanine- (pr-) based materials on human cells can be considered a controversial matter, while many contradictions exist.In this study, we focused on the synthesis of polyrhodanine/fe3o4 modified by graphene oxide and the effect of kombucha (ko) supernatant on results.The general structure of synthetic compounds was determined in detail through fourier-transform infrared spectroscopy (ft-ir).Also, obtained compounds were morphologically, magnetically, and chemically characterized using scanning electron microscopy (sem) and vibrating sample magnetometer (vsm), energy dispersive x-ray (edx) analysis.The antibacterial effects of all synthesized nanomaterials were done according to clsi against four infamous pathogens.Also, the cytotoxic effects of the synthesized compounds on the human liver cancer cell line (hep-g2) were assessed by mtt assay.Our results showed that go/fe has the highest average inhibitory effect against escherichia coli and pseudomonas aeruginosa, and this compound possesses the least antimicrobial effect on staphylococcus aureus.Considering the viability percent of cells in the pr/go/fe3o4 compound and comparing it with go/fe3o4, it can be understood that the toxic effects of polyrhodanine can diminish the metabolic activity of cells at higher concentrations (mostly more than 50 μg/m l), and pr/fe3o4/ko exhibited some promotive effects on cell growth, which enhanced the viability percent to more than 100%.Similarly, the cell viability percent of pr/go/fe3o4/ko compared to pr/go/fe3o4 is much higher, which can be attributed to the presence of kombucha in the compound.Consequently, based on the results, it can be concluded that this novel polyrhodanine-based nanocompound can act as drug carriers due to their low toxic effects and may open a new window on the antibacterial agents.

Journal: Bioinorganic Chemistry and Applications (2021)
Publication types: Research Article;
Bioinformatics Analysis of mRNAs and miRNAs for Identifying Potential Biomarkers in Lung Adenosquamous Carcinoma

Lung adenosquamous carcinoma (lasc) is a special type of lung cancer.Lasc is a malignant tumor with strong aggressiveness and a poor prognosis.Previous studies have revealed that micro rnas (mi rnas) are widely involved in the development of tumors by targeting m rna.This study is aimed at identifying the key m rnas and mi rnas of lasc and constructing mi rna-m rna networks for deeply comprehending the latent molecular mechanisms.Methods.M rna dataset (gse51852) and mi rna dataset (gse51853) were extracted and downloaded from the gene expression omnibus (geo) database.Differentially expressed genes (degs) and differentially expressed mi rnas (dems) were picked out by the geo2r web tool.Gene ontology (go) and kyoto encyclopedia of genes and genomes (kegg) functional enrichment analyses were conducted in the david database.The protein-protein interaction (ppi) network was performed and analyzed by using the string database and cytoscape software, respectively.Transmi r v2.0 was applied to predict potential transcription factors of mi rnas.The target genes of dems were predicted in the mi rwalk database.Results.In comparison to normal tissues, a total of 1458 degs (511 upregulated and 947 downregulated) and 13 dems (5 upregulated and 8 downregulated) were screened out in lasc tissues.The ppi network of the degs displayed five key modules and seventeen hub genes.Six target genes of the dems were predicted, and five essential mi rna-m rna regulatory pairs were established.Ensuingly, cenpf, one of the target genes, was also the hub genes of gse51852, which was obtained from mcode and cyto hubba and regulated by hsa-mi r-205.Conclusions.We constructed the mi rna-m rna regulatory pairs, which are helpful to study the potential regulatory mechanisms and find out promising diagnosis biomarkers and therapeutic targets for lasc.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;