syedzayyan/paper_mill_benchmark huggingface dataset:
Mapping and Analysing Potential Sources and Transmission Routes of Antimicrobial Resistant Organisms in the Environment using Geographic Information Systems-An Exploratory Study.

Antimicrobial resistance (amr) is one of the leading threats to human health worldwide.The identification of potential sources of antimicrobial resistant organisms (aros) and their transmission routes in the environment is important for improving our understanding of amr and to inform and improve policy and monitoring systems, as well as the identification of suitable sampling locations and potential intervention points.This exploratory study uses geographic information systems (gis) to analyse the spatial distribution of likely aro sources and transmission routes in four local authority areas (laas) in ireland.A review of relevant spatial data in each laa, grouped into themes, and categorised into sources and transmission routes, was undertaken.A range of gis techniques was used to extract, organise, and collate the spatial data into final products in the form of thematic maps for visual and spatial analysis.The results highlight the location of 'clusters' at increased risk of harbouring amr in each laa.They also demonstrate the relevance of aquatic transmission routes for aro mobility and risk of human exposure.The integration of a gis approach with expert knowledge of amr is shown to be a useful tool to gain insights into the spatial dimension of amr and to guide sampling campaigns and intervention points.

Journal: Antibiotics (Basel, Switzerland) (2019)
Publication types: Journal Article
AntifungalStreptomycesspp., Plausible Partners for Brood-Caring of the Dung BeetleCopris tripartitus.

The dung beetle copris tripartitus waterhouse (coleoptera: scarabaeidae) is a coprophagous insect that lives in and feeds primarily on the feces of mammalian herbivores and is known to protect their offspring from the pathogen-rich environment by performing parental care for brood balls.Brood balls under continuous management by dung beetle are rarely contaminated by entomopathogenic fungi compared to abandoned brood balls.On the supposition that dung beetles may benefit from mutualistic bacteria that protect their offspring against fungal pathogens, we evaluated the antifungal activities of bacteria isolated from the dung beetle and brood ball.As a result, bacterial isolates, mainly streptomycetes, manifested potent and broad-spectrum antifungal activity against various fungi, including entomopathogens.Of the isolates,streptomycessp.At67 exhibited pronounced antifungal activities.Culture-dependent and independent approaches show that this strain has occurred continuously in dung beetles that were collected over three years.Moreover, metabolic profiling and chemical investigation demonstrated that the strain produced an antifungal polyene macrocyclic lactam, sceliphrolactam, as a major product.Our findings imply that specific symbiotic bacteria of c.Tripartitusare likely to contribute brood ball hygiene by inhibiting fungal parasites in the environment.

Journal: Microorganisms (2021)
Publication types: Journal Article
The Use of Essential Oils and Their Isolated Compounds for the Treatment of Oral Candidiasis: A Literature Review.

In this literature review, we present the main scientific findings on the antifungal activity of essential oils (eos) applicable for a new drug formulation to treat oral candidiasis.Seven literature databases were systematically searched for eligible in vitro and clinical trials.Selected articles were screened for biological activity, botanical species, phytochemical composition, study design, and methodological quality.A total of 26 articles were included in the review, of which 21 were in vitro studies and 5 clinical trials.The most promising eos were obtained from allium tubeorosum,cinnamomum cassia,cinnamomum zeylanicum, and coriandrum sativum l.Among the phytochemicals, citral and thymol were the most active.Clinical trials indicated that the eos from pelargonium graveolensand zataria multifloraare potentially effective to treat oral candidiasis.Further nonclinical and clinical studies with these eo are warranted to determine their potential use and safety for the treatment of oral candidiasis.

Journal: Evidence-based complementary and alternative medicine : eCAM (2021)
Publication types: Journal Article;Review
Tritium distribution in typical plants around tritium laboratory in south-west of China.

A low-temperature desorption method was developed to remove the tissue free water tritium (tfwt) in plants, which dramatically reduces the sample-preparation time from several days to only 2-3 h.Two factors, including spatial distribution and seasonal variation, that influence the tritium distribution and the organic bound tritium (obt)/tfwt ratios in plants were investigated based on three different kinds of subtropical-basin plants located near the decommissioned nuclear facility in south-west of china.Under the same environmental condition, higher tritium concentration was seen in pine needle (pn) compared with flat bamboo-root (fbt) and wild cotton (wc), while these three plants show similar location- and season-dependent trend of tritium distribution.The location-dependent investigation shows that obt and tfwt concentration are significantly higher in plants growing in the downwind direction of the tritium laboratory than that in plants growing in the upwind and cross direction.In different seasons, the tfwt in plants reached peak in winter and valley in summer, while the obt increased continuously with the season changing from spring to winter.The ratios of obt/tfwt were investigated to evaluate the ability of plants to concentrate tritium into organic matter, which were 0.97-2.72 for pn, 0.89-1.64 for fbr, and 0.80-1.62 for wc.

Journal: Journal of environmental radioactivity (2021)
Publication types: Journal Article
Mammalian DNA Polymerase Kappa Activity and Specificity.

Dna polymerase (pol) kappa is a y-family translesion dna polymerase conserved throughout all domains of life.Pol kappa is special6 ized for the ability to copy dna containing minor groove dna adducts, especially n2-d g adducts, as well as to extend primer termini containing dna damage or mismatched base pairs.Pol kappa generally cannot copy dna containing major groove modifications or uv-induced photoproducts.Pol kappa can also copy structured or non-b-form dna, such as microsatellite dna, common fragile sites, and dna containing g quadruplexes.Thus, pol kappa has roles both in maintaining and compromising genomic integrity.The expression of pol kappa is altered in several different cancer types, which can lead to genome instability.In addition, many cancer-associated single-nucleotide polymorphisms have been reported in the polkgene, some of which are associated with poor survival and altered chemotherapy response.Because of this, identifying inhibitors of pol kappa is an active area of research.This review will address these activities of pol kappa, with a focus on lesion bypass and cellular mutagenesis.

Journal: Molecules (Basel, Switzerland) (2019)
Publication types: Journal Article;Review
Energy Flux Through the Magnetopause During Flux Transfer Events in Hybrid-Vlasov 2D Simulations.

Solar wind-magnetosphere coupling drives magnetospheric dynamic phenomena by enabling energy exchange between magnetospheric and solar wind plasmas.In this study, we examine two-dimensional noon-midnight meridional plane simulation runs of the global hybrid-vlasov code vlasiator with southward interplanetary magnetic field driving.We compute the energy flux, which consists of the poynting flux and hydrodynamic energy flux components, through the earth's magnetopause during flux transfer events (ftes).The results demonstrate the spatiotemporal variations of the energy flux along the magnetopause during an fte, associating the fte leading (trailing) edge with an energy injection into (escape from) the magnetosphere on the dayside.Furthermore, ftes traveling along the magnetopause transport energy to the nightside magnetosphere.We identify the tail lobes as a primary entry region for solar wind energy into the magnetosphere, consistent with results from global magnetohydrodynamic simulations and observations.

Journal: Geophysical research letters (2022)
Publication types: Journal Article
Metabolic assessment of cerebral palsy with normal clinical MRI using18F-FDG PET imaging: A preliminary report.

To explore the cerebral metabolic patterns of cerebral palsy (cp) patients without structural abnormalities by brain magnetic resonance imaging (mri) scans, we evaluated18f-fluoro-deoxyglucose positron emission tomography (18f-fdg pet) imaging features in patients.Thirty-one children with cp [gross motor function classification system (gmfcs) levels ii-v] showing no structural abnormalities by mri were enrolled in this study.Regional glucose metabolic activity values were calculated using scenium software and compared between the right and left cerebral hemispheres.These comparisons revealed asymmetric metabolic reductions in the central region, cerebellum, frontal lobe, and parietal lobe (p< 0.01).We next determined whether averaged brain metabolic activity values in different brain regions correlated with gmfcs levels.The metabolic activity values of basal ganglia, left temporal lobe, and cerebellum correlated negatively with gmfcs scores (allp< 0.05).This method was applied to the left cerebellum, which showed higher metabolic activity values than those in the right cerebellum in most patients (83.8%), and these values also correlated negatively with gmfcs scores (spearman'sr= -0.36,p= 0.01).Differential cortical glucose metabolism by18f-fdg pet, may help to distinguish between different cp diagnoses that are not detected by mri.

Journal: Frontiers in neurology (2022)
Publication types: Journal Article
Travel-related infection in Guangzhou, China,2009-2019.

We analyzed the epidemiological characteristics of travel-related infectious diseases in reported guangzhou between 2009 and 2019 to provide a scientific basis for prevention and control strategies.Method the infectious diseases report information system of china was mined for case reports, combined with clinical diagnosis records, and analyzed.Results between 2009 and 2019, 1478 cases of imported infectious diseases were reported in guangzhou.Dengue fever accounted for 46.14%of cases and malaria accounted for 45.47% of cases.The patients with imported travel-related infection cases were mainly male (75.88%), chinese (75.57%), and aged 20-45 years (83.01%).Cases increased from may each year, peaked between august and september, and declined rapidly after october.The main source areas of import were africa and other countries in asia.Conclusions dengue fever and malaria are the main travel-related infection in guangzhou, and are generally brought in by male chinese workers.Intervention and health education in this population should be strengthened to prevent and control travel-related infection.

Journal: Travel medicine and infectious disease (2021)
Publication types: Journal Article
Joint Communications and Sensing Employing Multi- or Single-Carrier OFDM Communication Signals: A Tutorial on Sensing Methods, Recent Progress and a Novel Design.

Joint communications and sensing (jcas) has recently attracted extensive attention due to its potential in substantially improving the cost, energy and spectral efficiency of internet of things (io t) systems that need both radio frequency functions.Given the wide applicability of orthogonal frequency division multiplexing (ofdm) in modern communications, ofdm sensing has become one of the major research topics of jcas.To raise the awareness of some critical yet long-overlooked issues that restrict the ofdm sensing capability, a comprehensive overview of ofdm sensing is provided first in this paper, and then a tutorial on the issues is presented.Moreover, some recent research efforts for addressing the issues are reviewed, with interesting designs and results highlighted.In addition, the redundancy in ofdm sensing signals is unveiled, on which, a novel method is based and developed in order to remove the redundancy by introducing efficient signal decimation.Corroborated by analysis and simulation results, the new method further reduces the sensing complexity over one of the most efficient methods to date, with a minimal impact on the sensing performance.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article
Sensopeptidomic Kinetic Approach Combined with Decision Trees and Random Forests to Study the Bitterness during Enzymatic Hydrolysis Kinetics of Micellar Caseins.

Protein hydrolysates are, in general, mixtures of amino acids and small peptides able to supply the body with the constituent elements of proteins in a directly assimilable form.They are therefore characterised as products with high nutritional value.However, hydrolysed proteins display an unpleasant bitter taste and possible off-flavours which limit the field of their nutrition applications.The successful identification and characterisation of bitter protein hydrolysates and, more precisely, the peptides responsible for this unpleasant taste are essential for nutritional research.Due to the large number of peptides generated during hydrolysis, there is an urgent need to develop methods in order to rapidly characterise the bitterness of protein hydrolysates.In this article, two enzymatic hydrolysis kinetics of micellar milk caseins were performed for 9 h.For both kinetics, the optimal time to obtain a hydrolysate with appreciable organoleptic qualities is 5 h.Then, the influence of the presence or absence of peptides and their intensity over time compared to the different sensory characteristics of hydrolysates was studied using heat maps, random forests and regression trees.A total of 22 peptides formed during the enzymatic proteolysis of micellar caseins and influencing the bitterness the most were identified.These methods represent simple and efficient tools to identify the peptides susceptibly responsible for bitterness intensity and predict the main sensory feature of micellar casein enzymatic hydrolysates.

Journal: Foods (Basel, Switzerland) (2021)
Publication types: Journal Article
Development of Smartphone Application for Markerless Three-Dimensional Motion Capture Based on Deep Learning Model.

To quantitatively assess pathological gait, we developed a novel smartphone application for full-body human motion tracking in real time from markerless video-based images using a smartphone monocular camera and deep learning.As training data for deep learning, the original three-dimensional (3d) dataset comprising more than 1 million captured images from the 3d motion of 90 humanoid characters and the two-dimensional dataset of coco 2017 were prepared.The 3d heatmap offset data consisting of 28 × 28 × 28 blocks with three red-green-blue colors at the 24 key points of the entire body motion were learned using the convolutional neural network, modified res net34.At each key point, the hottest spot deviating from the center of the cell was learned using the tanh function.Our new i os application could detect the relative tri-axial coordinates of the 24 whole-body key points centered on the navel in real time without any markers for motion capture.By using the relative coordinates, the 3d angles of the neck, lumbar, bilateral hip, knee, and ankle joints were estimated.Any human motion could be quantitatively and easily assessed using a new smartphone application named three-dimensional pose tracker for gait test (tdpt-gt) without any body markers or multipoint cameras.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article
Socioeconomic inequalities in health care utilization in Paraguay: Description of trends from 1999 to 2018.

Paraguay's health care system is characterized by segmented provision and low public spending, with limited coverage and asymmetries in terms of access and quality of care.The present study provides national estimates of income-related inequality in health care utilization and trends in the country over the past two decades.Methods using data from the paraguayan permanent household survey, we estimated socioeconomic inequality in health care use during the period 1999-2018.We used poverty-to-income ratio as the socioeconomic stratifier and defined health care use as having reported a health problem and subsequent health care use in the last 90 days before interview.Inequality was summarized by rank- and level-based versions of the concentration index for binary outcomes.Results inequalities affecting those with lower incomes were present in all years assessed, although the magnitude of these inequalities declined over time.Inequality as expressed by the rank-based index decreased from 0.209 (95%ci 0.164; 0.253) in 1999 to 0.032 (95%ci -0.010; 0.075) in 2018.The level-based index decreased from 0.076 (95%ci -0.029; 0.182) in 1999 to 0.024 (0.002; 0.045) in 2018.Trends in both indices were generally stable from 1999 to 2009, with a noticeable decrease in 2010.The sharpest decreases relative to the 1999 baseline were observed in the period 2010-2018, reflecting changes in health care use and income distribution.Stratification by area, sex and older people suggest similar trends within subgroups.Conclusions decreases in inequality coincide temporally with increments in public health expenditure, removal of user fees in public health care facilities and the expansion of conditional cash-transfer programmes.Future research should disentangle the role of each of these policies in explaining the trends described.

Journal: Journal of health services research & policy (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Non-destructive evaluation of watermelon seeds germination by using Delayed Luminescence.

The evaluation of optical properties of biological samples is gaining increasing interests both in scientific and commercial fields concerning agriculture and food processing.The optical techniques can indeed be able to provide information on quality assessment in a fast and non-destructive way.This feature makes them suitable for automatic management of control processes.In this paper, we propose to use the delayed luminescence, a ultra-weak and photo-induced emission of optical photons, as a tool for a rapid evaluation of germination performance, the principal index reflecting seed quality.Two lots of 'mirella' f1watermelon dried seeds, of 96 seeds each, were considered.The seeds were analyzed in the conditions as provided by seed/breeding company.Characteristics of delayed luminescence emission from each single seed were correlated to the different germination levels as assessed by international seed testing procedures.Parametric differences in the two lots were determined, based on the relaxation kinetics of some spectral components.A control test, with the aim to construct a calibration model, was conceived and successfully tested.Time decays of delayed luminescence spectral components at central wavelengths 450 nm, 550 nm and 650 nm, corresponding to spectrum region where natural biomarkers as nadh, flavins and lipopigments, protoporphyrin and ros respectively emit, have been evaluated.The results show that such time decays are strictly connected to the biological state of the system under analysis and allow also proposing delayed luminescence measurement as a quick, cheap and non-destructive test for seed viability analysis.

Journal: Journal of photochemistry and photobiology. B, Biology (2018)
Publication types: Journal Article
Analysis of highly polar pesticides in foods by LC-MS/MS.

Highly polar pesticides (hpp) are a group of pesticides that are characterize as low log kow.Many high-throughput multi-residue analysis methods based on liquid chromatography-tandem mass spectrometry (lc-ms/ms) for the simultaneous determination of such polar pesticides have been proposed.In this article, we summarize the various sample preparation methods including quick polar pesticides (qu ppe), dispersive solid phase extraction (d spe), solid phase extraction (spe) and qu ech ers (quick, easy, cheap, effective, rugged and safe), especially for qu ppe, which are mainly used for the determination of hpp in foods.In addition, we summarize lc-based separation methodologies that are currently used for the analysis of hpp in foods, including reversed-phase chromatography (rpc), hydrophilic interaction liquid chromatography (hilic), ion chromatography (ic) and mixed-mode chromatography (mmc).Finally, the current mass spectrometry-based methodologies for the analysis of hpp are summarized with a specific focus on ms configurations and acquisition modes.

Journal: Journal of food and drug analysis (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't
Fathers' experiences of supporting their partners during their preterm infant's stay in the neonatal intensive care unit: a multi-method study.

To explore how the fathers experience their role as a support for their partner and the relationship with them during their preterm infant's stay in the nicu.Study design multi-method longitudinal study involving ethnographic observation, semi-structured interviews, self-report questionnaires, and clinical information.Twenty fathers of preterm infants hospitalized in a level-iii-nicu were included.Data were analyzed using thematic continent analysis.Results three main themes were identified: support for mother (subthemes: putting mother's and infant's needs first; hiding worries and negative emotions; counteracting the sense of guilt; fear that the mother would reject the child), mother's care for the infant (subthemes: observing mother engaged in caregiving; mother has "something extra"), and couple relationship (subthemes: collaboration; bond).Conclusion fathers supporting their partners during the stay in the nicu experience emotional distress and the need for being supported that often are hidden.This demands a great deal of emotional and physical energy.

Journal: Journal of perinatology : official journal of the California Perinatal Association (2022)
Publication types: Journal Article
Nuclear Factor Erythroid 2-Related Factor 2 in Vitiligo.

Vitiligo is a pigmentary disorder, in which oxidative stress has been evidenced as part of the pathogenesis.Pathways responsible for protecting melanocytes from damage caused by reactive oxygen species are known as the nuclear factor erythroid factor 2 (nrf2) pathway.Nrf2 is a transcription factor that remains inhibited when the organism is in homeostasis, but in the presence of oxidative stress it allows the encoding of phase ii antioxidant enzymes.In vitiligo there are abnormalities in the location and function of nrf2 as well as polymorphisms that increase the risk of this disease.Currently, multiple molecules that act on nrf2 have been investigated in order to find useful emerging treatments for vitiligo.A search for articles in spanish and english was carried out in the pub med, ovid, scopus and web of science clarivate databases, using the keywords "vitiligo and nuclear factor erythroid derived 2 like 2 or nrf2" without time restriction.All in vitro studies, narrative reviews, case series, cohort studies, and randomized and non-randomized clinical trials that specifically addressed the issue of nrf2 associated with vitiligo were included.

Journal: Actas dermo-sifiliograficas (2022)
Publication types: Journal Article;Review