syedzayyan/paper_mill_benchmark huggingface dataset:
FDXR Gene Expression afterin VivoRadiation Exposure of Pediatric Patients Undergoing Interventional Cardiology Procedures.

Ferredoxin reductase (fdxr) has already been reported as a promising biomarker for estimating radiation doses in radiotherapy.This study aimed to investigate the responsiveness of fdxr on pediatric population exposed to ionizing radiation (x-rays) during pediatric interventional cardiology (ic) procedures.Patients and methods peripheral blood was collected by venipuncture from 24 pediatric donors before and 24 hours after the ic procedure.To estimate the effective dose, demographic data and air kerma-area product (pka) were recorded for each patient.The relative quantification (rq) of the fdxr gene in irradiated patient blood samples compared to the non-irradiated blood samples was determined using q pcr analysis.The relative values of fdxr were log- transformed.Results the effective dose ranged from 0.002 m sv to 8.004 m sv.Over this radiation exposure range, the fdxr gene expression varied randomly with the effective dose.Up-regulation in fdxr expression was observed in 17 patients and down-regulation in 7 patients.Conclusions further studies in a larger cohort of pediatric patients along with the record of clinical data are needed to determine whether fdxr gene expression is an effective biomarker for radiation exposure estimation in pediatric imaging.

Journal: Frontiers in bioscience (Landmark edition) (2022)
Publication types: Journal Article
Effect of low frequency stimulation of olfactory bulb on seizure severity, learning, and memory in kindled rats.

Low frequency deep brain electrical stimulation (lfs) is a potential therapeutic strategy to control seizures in epilepsy patients.Given the functional connection of the olfactory bulb with the hippocampal formation, in this study the effect of applying lfs in the olfactory bulb on seizure severity, and learning and memory was investigated in hippocampal kindling.In male wistar rats (250-300 g), a tripolar electrode was inserted in the ca1 region of the right hippocampus to apply kindling stimulations and record the afterdischarges (ads).Two bipolar electrodes were also inserted bilaterally into the olfactory bulbs for applying lfs.In the kindled group, the animals received daily kindling stimulations to produce stage 5 seizures for three consecutive days.In one group of subjects, lfs was administered 2-3 min after the last kindling stimulation.Within this group, subjects were divided into two subgroups: one subgroup received two and the other subgroup received four packages of lfs protocol.Obtained data showed that bilateral lfs application to the left and right olfactory bulb reduced seizure severity.Among the protocols, applying four packages of lfs had a greater anticonvulsant effect compared to applying two packages lfs.Applying lfs in the olfactory bulb of kindled subject restored performance on measures that test short- and long-term memory - the y maze and morris water maze test - and applying four packages of lfs was more effective than two.These results indicated that applying lfs to the olfactory bulb had anticonvulsant effects and ameliorated the seizure-induced impairment of working and spatial memory.These effects appear to be depended on the number of applied lfs and were greater by increasing the number of lfs.

Journal: Epilepsy research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Changes in High-Frequency Intracardiac Electrogram Indicate Cardiac Ischemia.

High-frequency qrs (hfqrs) analysis of surface ecg is a reliable marker of cardiac ischemia (ci).This study aimed to assess the response of hfqrs signals from standard intracardiac electrodes (i hfqrs) to ci in swine and compare them with conventional st-segment deviations.Devices with three intracardiac leads were implanted in three swine in a controlled environment.Ci was induced by inflating a balloon in epicardial coronary arteries.A designated signal-processing algorithm was applied to quantify the i hfqrs content before, during, and after each occlusion.I hfqrs time responses were compared to conventional st-segment deviations.Thirty-three over thirty-nine (85%) of the occlusions presented significant reduction in the i hfqrs signal, preceding st-segment change, being the only indicator of ci in brief occlusions.I hfqrs was found to be an early indicator for the onset of ci and demonstrated superior sensitivity to conventional st-segment deviations during brief ischemic episodes.

Journal: Journal of cardiovascular translational research (2022)
Publication types: Journal Article
The Forefront of Dentistry-Promising Tech-Innovations and New Treatments.

This article discusses innovations in technology and treatments that have enormous potential to revolutionize our dental care, including novel concepts in electronic health records, communication between dentists and patients, biologics around diagnosis and treatment, digital dentistry, and, finally, the real-time optimization of information technology.The early implementation and validation of these innovations can drive down their costs and provide better dental and medical services to all members of our society.

Journal: JDR clinical and translational research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Research Support, N.I.H., Extramural
Chemical Markers of Human Tendon Health Identified Using Raman Spectroscopy: Potential for In Vivo Assessment.

The purpose of this study is to determine whether age-related changes to tendon matrix molecules can be detected using raman spectroscopy.Raman spectra were collected from human achilles (n = 8) and tibialis anterior (n = 8) tendon tissue excised from young (17 ± 3 years) and old (72 ± 7 years) age groups.Normalised raman spectra underwent principal component analysis (pca), to objectively identify differences between age groups and tendon types.Certain raman band intensities were correlated with levels of advanced glycation end-product (age) collagen crosslinks, quantified using conventional destructive biochemistry techniques.Achilles and tibialis anterior tendons in the old age group demonstrated significantly higher overall raman intensities and fluorescence levels compared to young tendons.Pca was able to distinguish young and old age groups and different tendon types.Raman intensities differed significantly for several bands, including those previously associated with age crosslinks, where a significant positive correlation with biochemical measures was demonstrated.Differences in raman spectra between old and young tendon tissue and correlation with age crosslinks provides the basis for quantifying age-related chemical modifications to tendon matrix molecules in intact tissue.Our results suggest that raman spectroscopy may provide a powerful tool to assess tendon health and vitality in the future.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article
Human β-defensin 2 ameliorates acute GVHD by limiting ileal neutrophil infiltration and restraining T cell receptor signaling.

Acute graft-versus-host disease (a gvhd), which is driven by allogeneic t cells, has a high mortality rate and limited treatment options.Human β-defensin 2 (h bd-2) is an endogenous epithelial cell-derived host-defense peptide.In addition to its antimicrobial effects, h bd-2 has immunomodulatory functions thought to be mediated by ccr2 and ccr6 in myeloid cells.In this study, we analyzed the effect of recombinant h bd-2 on a gvhd development.We found that intestinal β-defensin expression was inadequately induced in response to inflammation in two independent cohorts of patients with a gvhd and in a murine a gvhd model.Treatment of mice with h bd-2 reduced gvhd severity and mortality and modulated the intestinal microbiota composition, resulting in reduced neutrophil infiltration in the ileum.Furthermore, h bd-2 treatment decreased proliferation and proinflammatory cytokine production by allogeneic t cells in vivo while preserving the beneficial graft-versus-leukemia effect.Using transcriptome and kinome profiling, we found that h bd-2 directly dampened primary murine and human allogeneic t cell proliferation, activation, and metabolism in a ccr2- and ccr6-independent manner by reducing proximal t cell receptor signaling.Furthermore, h bd-2 treatment diminished alloreactive t cell infiltration and the expression of genes involved in t cell receptor signaling in the ilea of mice with a gvhd.Together, we found that both human and murine a gvhd were characterized by a lack of intestinal β-defensin induction and that recombinant h bd-2 represents a potential therapeutic strategy to counterbalance endogenous h bd-2 deficiency.

Journal: Science translational medicine (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Aging effect on vanadium oxide hybrid nanotubes.

Vanadium oxides present a rich magnetic phase diagram depending on the oxidation state of the v ions.In particular the vanadium oxide nanotubes (vox nts) present several promising perspectives for different technological applications for which it is essential to know the oxidation state of v ions, as well as to evaluate the stability with the aging time of the tubes.In this work we present a systematic study of the time evolution of the magnetic properties of vox nts.For this complete characterization, we used electron spin resonance (esr) and dc-susceptibility techniques, which were supplemented with tem microscopy and xanes.We observed that for aging in normal environmental conditions of pressure, temperature and humidity, the v4+ions oxidize to v5+.Although the multiwall tubular structure is maintained, this oxidation process produces a marked change in the magnetic properties.We conclude that the aging of the samples affects the v4+/v5+relationship in the vox nts, which may contribute to explain the significant dispersion of data reported in the bibliography.

Journal: Journal of physics. Condensed matter : an Institute of Physics journal (2019)
Publication types: Journal Article
"It's a revolving door": Ego-depletion among prisoners with injecting drug use histories as a barrier to post-release success.

People who inject drugs (pwid) are overrepresented among prisoner populations worldwide.This qualitative study used the psychological concept of "ego-depletion" as an exploratory framework to better understand the disproportionate rates of reincarceration among people with injecting drug use histories.The aim was to illuminate mechanisms by which prospects for positive post-release outcomes for pwid are enhanced or constricted.Methods participants were recruited from a longitudinal cohort study, super mix, in victoria, australia.Eligible participants were invited to participate in an in-depth interview.Inclusion criteria were: aged 18+; lifetime history of injecting drug use; incarcerated for >three months and released from custody <12 months previously.Analysis of 48 interviews examined how concepts relevant to the ego-depletion framework (self-regulation; standards; consequences and mitigators of ego-depletion) manifested in participants' narratives.Results predominantly, participants aimed to avoid a return to problematic drug use and recidivism, and engaged in effortful self-regulation to pursue their post-release goals.Post-release environments were found to diminish self-regulation resources, leading to states of ego-depletion and compromising the capacity to self-regulate according to their ideals.Fatalism, stress, and fatigue associated with the transition period exacerbated ego-depletion.Strategies that mitigated ego-depletion included avoidance of triggering environments; reducing stress through opioid agonist therapy; and fostering positive affect through supportive relationships.Conclusions post-release environments are ego-depleting and inconducive to sustaining behavioural changes for pwid leaving prison.Corrections' behaviourist paradigms take insufficient account of the socio-structural factors impacting on an individual's self-regulation capacities in the context of drug dependence and desistance processes.Breaking the cycles of reincarceration among pwid requires new approaches that moderate ego-depletion and facilitate long-term goal-pursuit.

Journal: The International journal on drug policy (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Sex differences in time to primary percutaneous coronary intervention and outcomes in patients presenting with ST-segment elevation myocardial infarction.

S we assessed sex differences in treatment and outcomes in st-segment elevation myocardial infarction (stemi) patients treated with primary percutaneous coronary intervention (pci).Background historically, delays to timely reperfusion and poorer outcomes have been described in women who suffer stemi.However, whether these sex discrepancies still exist with contemporary stemi treatment remains to be evaluated.Methods consecutive stemi patients treated with primary pci patients over a 10-year period (january 1, 2010 to december 31, 2019) from a tertiary referral center were assessed.Comparisons were performed between patient's sex.Primary outcomes were 30-day and 1-year mortality.Secondary outcomes were stemi performance measures.Results most patients (n = 950; 76%) were male.Females were on average older (66.8 vs.61.4 years males; p < 0.001).Prehospital treatment delays did not differ between sexes (54 min [iqr: 44-65] females vs.52 min [iqr: 43-62] males; p = 0.061).Stemi performance measures (door-to-balloon, first medical contact-to-balloon [fmctb]) differed significantly with longer median durations in females and fewer females achieving fmctb < 90 min (28% females vs.39% males; p < 0.001).Women also experienced greater rates of initial radial arterial access failure (11.3% vs.3.1%; p < 0.001).However, there were no significant sex differences in crude or adjusted mortality between sexes at 30-days (3.6% male vs.5.1% female; p = 0.241, adjusted or: 1.1, 95% ci: 0.5-2.2, p = 0.82) or at 1-year (4.8% male vs.6.8% female; p = 0.190, adjusted or: 1.0, (95% ci: 0.5-1.8; p = 0.96).Conclusion small discrepancies between sexes in measures of timely reperfusion for stemi still exist.No significant sex differences were observed in either 30-day or 1-year mortality.

Journal: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions (2022)
Publication types: Journal Article
Serum magnesium levels in hospitalized patients with SARS-CoV-2.

Early studies have reported various electrolyte abnormalities at admission in patients with severe covid-19.104 out of 193 patients admitted to our institution presented with hypermagnesemia at presentation.It is believed this may be important in the evaluation of severe sars-co v-2 infections.This study evaluated the outcomes of hypermagnesemia in patients with covid-19.A retrospective chart review of patients admitted to the hospital with confirmed sars-co v-2 infection was conducted.A review of the medical literature regarding hypermagnesemia, magnesium levels in critical care illness and electrolyte abnormalities in patients with covid-19 was performed.Differences in demographic and clinical characteristics of patients with hypermagnesemia and normomagnesemia were evaluated using descriptive statistics.Other known variables of disease severity were analyzed.104 patients (54%) were identified with hypermagnesemia (≥2.5 mg/d l).48 of those patients were admitted to the intensive care unit (46%, p<0.001).34 patients required ventilator support (32%, p<0.0001).With age-adjusted logistic regression analysis hypermagnesemia was associated with mortality (p=0.007).This study demonstrates that hypermagnesemia is a significant marker of disease severity and adverse outcome in sars-co v-2 infections.We recommend serum magnesium be added to the panel of tests routinely ordered in evaluation of severe sars-co v-2 infections.

Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research (2022)
Publication types: Journal Article;Review
Moderators of Response to Personalized and Standard Care Cognitive-Behavioral Therapy for Youth with Autism Spectrum Disorder and Comorbid Anxiety.

Anxiety/obsessive-compulsive disorders are common among youth with autism spectrum disorder (asd).Two versions of cognitive behavior therapy (cbt) are effective, with some advantage for a personalized, adapted version.This study evaluated predictors and moderators of standard cbt and adapted cbt.Youth (n = 167) ages 7-13 were randomized to standard or adapted cbt, or treatment-as-usual.Age, iq, asd severity, and emotional-behavioral symptom severity were examined.More severe internalizing and emotional-behavioral problems predicted poorer treatment outcomes especially in standard versus personalized cbt.Elevated repetitive behaviors and restricted interests predicted poorer treatment outcomes across treatments, though youth with "moderate" repetitive behaviors and restricted interested experienced poorer outcomes only in standard but not personalized cbt.Externalizing symptoms directly predicted treatment outcomes.Older age predicted improved outcomes in adapted but not standard cbt.Findings highlight the need for further treatment refinements and the value in adapting treatment for youth with more complex presentations.Trial registration clinicialtrials.gov: nct02028247; .

Journal: Journal of autism and developmental disorders (2022)
Publication types: Journal Article;Randomized Controlled Trial
Research to law: A qualitative study of Massachusetts' 2018 Care Act expanding emergency department initiation of medication for opioid use disorder.

Initiating medication for opioid use disorder (moud) during emergency department (ed) visits is an important innovation to engage individuals in addiction treatment.In 2018, massachusetts passed the care act, becoming the first state to legislate that hospitals with eds must be able to offer moud.We performed a qualitative study to explore factors influencing policy enactment.Methods semi-structured interviews were conducted in 2019 with ten key stakeholders involved in the policymaking process representing state government, hospitals, physician professional societies, and recovery/behavioral health organizations.Data were analyzed in 2020-2021 using a hybrid inductive-deductive approach.Results the first key theme stakeholders expressed was the importance of research and public health consensus; they described consensus building within existing coalitions regarding the pressing need for action, and supporting expansion of treatment with this evidence-based strategy.Second, stakeholders discussed overcoming financing and feasibility concerns by passing budget-neutral legislation and ensuring flexibility for diverse hospital types.Lastly, stakeholders looked towards implementation, describing the implementation guide development process and ensuring capacity for continuing treatment existed throughout the state.Conclusions this study suggests that research supporting the effectiveness of ed moud induction drove the passage of this state legislation.Long-term collaboration between diverse stakeholders towards a common goal of increasing access to evidence-based treatment to address the opioid epidemic was also perceived as facilitating the law's passage.Policymakers and advocates in other states may look towards massachusetts's legislative process as a model for implementing similar legislation as part of their strategies to address the drug overdose crisis.

Journal: Journal of substance abuse treatment (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Risk of CVD Following Radiotherapy for Head and Neck Cancer: An Updated Systematic Review and Meta-Analysis.

The relative risk for cerebrovascular disease (cvd) is increased in patients with head and neck cancer (hnc) treated with radiotherapy (rt).However, the current relative risk for cvd following rt has not been well clarified.The purpose of this study was to analyze the effect of rt and update the risk of cvd following rt in hnc patients through a systematic review and meta-analysis.Material and methods we conducted an online database search and systematic review of observational studies that reported on cvd and extracranial carotid stenosis in patients with hnc who had undergone rt.Articles published in medline and pub med from 1980 to 2021 were identified and collected.Results of the forty-seven articles identified from pub med and forty-four articles identified from 3 systematic reviews, twenty-two studies were included.We found that neck rt was a significant risk factor for cvd (hr 3.97, 95% ci: 2.89-5.45).Patients with hnc treated by rt had an increased or (7.36, 95% ci: 4.13-13.11) for cvd, and approximately 26% (95% ci: 22%-31%) of hnc patients treated with rt were at risk for cvd with more than 50% reduction in carotid diameter.Conclusion the risk of cvd is increased in patients with hnc treated by rt, and recent improvements in rt techniques may have contributed to the decreased risk of cvd.These results suggest that regular follow-up and appropriate screening for cvd should be required for patients with hnc.

Journal: Frontiers in oncology (2022)
Publication types: Systematic Review;Journal Article
A Participatory Evaluation Framework for the Implementation of a Transdisciplinary Center for Health Disparities Research.

This article describes the participatory evaluation framework for the transdisciplinary collaborative center for health disparities research (tcc) funded by the national institute of minority health and health disparities.In collaboration with tcc stakeholders, logic models, the mc kinlay model, and process and outcome evaluation plans, including quantitative and qualitative methods, have been developed and used to document the impact of the tcc.The mc kinlay model, a widely used comprehensive health model for eliminating health disparities, was also tailored to document the outcomes of the tcc.The process and outcome evaluation plans for the tcc guide continuous improvement and the achievement of its specific aims.The evaluation of the tcc occurred between 2012 and 2019 and involved key stakeholders in tcc research and programming.Several challenges exist for implementing an evaluation plan of a health equity-focused policy research center.However, we learned several lessons that will ensure progress toward specific aims and will help the tcc serve as a model for similar programs and centers.

Journal: Ethnicity & disease (2019)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, U.S. Gov't, P.H.S.