syedzayyan/paper_mill_benchmark huggingface dataset:
Impacts of the COVID-19 Shutdown on Gambling Patterns in Australia: Consideration of Problem Gambling and Psychological Distress.

S the covid-19 pandemic reduced access to gambling and contributed to widespread psychological distress.Psychological distress is a known risk factor for problem gambling as it can motivate excessive gambling as a coping response.The availability of gambling is considered a factor in maintaining problems.This paper aimed to investigate the impact of the shutdown of gambling venues on australians, particularly among those vulnerable to mental health problems and gambling disorder.Methods australian adults who had gambled at least once in the past 12 months (n = 764, 85.2% male) completed an online cross-sectional survey.Self-report measures retrospectively assessed typical monthly gambling frequency and expenditure before and after the covid-19 venue shutdown, problem gambling, and psychological distress.Results significant median decreases in gambling frequency were observed, both online and overall.No relationship was found between psychological distress and baseline or increases in gambling.Greater problem gambling severity was related to higher baseline gambling, but not to increases in gambling.Exploratory analysis showed that individuals engaged in moderate-risk gambling, but not problem gambling, were more likely to report increased gambling frequency compared to nonproblem and low-risk gamblers combined.Conclusions findings provide important insights into how changes in availability influence gambling participation, and for understanding the effectiveness of forced restrictions and venue exclusion strategies.Most people moderated their gambling when venue-based gambling was unavailable and opportunities for sports betting were limited.However, harms experienced by individuals with some gambling problems may have been exacerbated during the period of limited access.Policies to enhance prevention and treatment of gambling problems are necessary even when availability is reduced.

Journal: Journal of addiction medicine (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Predictors of Visual Acuity and Usefulness of a Treatment Algorithm in Rhinogenous Optic Neuritis.

Rhinogenous optic neuritis, which causes neuropathy associated with visual dysfunction, greatly reduces patient quality of life and requires suitable early treatment.This study aimed to analyze visual outcome predictors in patients with rhinogenous optic neuritis and to develop and investigate the usefulness of an algorithm to facilitate early treatment.Prospective and retrospective investigations were conducted at the department of otorhinolaryngology.The visual outcomes after sinus surgery of 24 of 53 patients suspected of having rhinogenous optic neuritis were analyzed.Furthermore, the usefulness of the treatment algorithm was evaluated in 27 of these 53 patients.Data from 24 patients who underwent surgery were included in a multiple regression analysis to investigate the associations between visual outcomes and concomitant symptoms and the time from symptom onset to surgery.The mean time from the initial examination to a request for otorhinolaryngological examination to assess the usefulness of the treatment algorithm was compared in 27 patients who did not undergo an initial otorhinolaryngological examination.Visual acuity improved in 23 participants who underwent surgery.Multivariate analysis identified the time from onset to surgery and headache as significant predictors of postoperative visual acuity.The mean time from the initial examination to a request for otorhinolaryngological examination was significantly shorter after the algorithm was introduced (1.13 days, 8 patients;p= .008).Early surgical treatment is essential to avoid further postoperative visual acuity decreases in patients with rhinogenous optic neuritis.Patients who experience headache may have poorer postoperative outcomes.

Journal: Ear, nose, & throat journal (2021)
Publication types: Evaluation Study;Journal Article
Quantitative Trait Locus Determining the Time of Blood Feeding in Culex pipiens (Diptera: Culicidae).

Mosquitoes and other blood feeding arthropods are vectors of pathogens causing serious human diseases, such as plasmodium spp.(malaria), wuchereria bancrofti (lymphatic filariasis), borrelia burgdorferi (lyme disease), and viruses causing dengue, zika, west nile, chikungunya, and yellow fever.Among the most effective strategies for the prevention of vector-borne diseases are those aimed at reducing human-vector interactions, such as insecticide applications and insecticide-treated bed nets (itns).In some areas where itns are widely used, behavioral adaptations have resulted in mosquitoes shifting their time of blood feeding to earlier or later in the night when the bed nets are not being employed.Little is known about the genetic basis of these behavioral shifts.We conducted quantitative trait locus (qtl) analysis using two strains of culex pipiens sensu lato with contrasting blood feeding behaviors, wherein the lab adapted shasta strain blood feeds at any time of the day or night, while the newly established trinidad strain feeds only at night.We identified a single locus on chromosome 2 associated with the observed variation in feeding times.None of the core clock genes period, timeless, clock, cycle, par-domain protein 1, vrille, discs overgrown, cryptochrome 1, or cryptochrome 2 were located within the qtl region.We then monitored locomotor behavior to determine if they differed in their flight activity.The highly nocturnal trinidad strain showed little daytime activity while the day-feeding shasta strain was active during the day, suggesting blood feeding behavior and flight activity are physiologically linked.

Journal: Journal of medical entomology (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, U.S. Gov't, Non-P.H.S.
Performance and outcome of the subcutaneous implantable cardioverter-defibrillator after transvenous lead extraction.

S the subcutaneous cardioverter-defibrillator (s-icd) may be a valuable option in patients after successful transvenous lead extraction (tle) without indication for pacemaker therapy and persistent risk of sudden cardiac death.The aim of this study was to evaluate device performance, postoperative outcome, and safety in patients who received a s-icd after tle compared to patients who underwent de-novo s-icd implantation.Methods a retrospective analysis of all patients included into our institution's s-icd database between september 2010 and may 2019 was conducted.the patients were divided in two groups, depending on whether they had received their s-icd after tle (n = 31) or de-novo (n = 113).Results the tle group was significantly older with a mean age of 54.3 ± 15.7 versus 46.7 ± 14.4 years; p = .007.Leading s-icd indication in the tle group was previous infection (50%), whereas in the de-novo group the s-icd was primarily chosen due to young patient age (74.6%).Median duration of follow-up was 527.0 versus 472.5 days, respectively; p = .576.Most common complication during follow-up was inappropriate icd therapy (12.9% vs.13.3%); p = 1.000.Pocket erosion/infection occurred in 3.2% versus 3.5% with no reported cases of systemic (re-)infection in either group; p = 1.000.All-cause mortality was low (6.2% vs.2.7%) and entirely unrelated to s-icd implantation or the device itself; p = .293.Conclusion the s-icd is a safe and effective alternative for patients after tle with very similar results regarding device performance and postoperative outcome, when compared to patients who underwent de-novo s-icd implantation.

Journal: Pacing and clinical electrophysiology : PACE (2021)
Publication types: Journal Article
A study of factors influencing Chinese college students' intention of using metaverse technology for basketball learning: Extending the technology acceptance model.

Introduction based on the expansion of flow constructs based on the tam model, this study assesses the impact of metaverse technology in college basketball courses.Methods we surveyed 849 effective samples using an online questionnaire survey, verified our analysis using structural equation modeling, and examined the moderating effect of gender on the path relationship.Results the perceived ease of use, the flow experience, and the perceived usefulness of the product are important predictors of behavioral intention.According to the study, perceived usefulness, and flow experience influence attitudes significantly.A moderating effect of gender is observed on perceived ease of use on the path to behavioral intention, and the results extend the theoretical research on the use of metaverse technology for basketball instruction and tam.Discussion a metaverse-based learning experience can enhance the flow experience of basketball learning, thus increasing the willingness to use and the effectiveness of learning.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article
The Fragility of Statistically Significant Results in Randomized Clinical Trials for COVID-19.

Importance interpreting results from randomized clinical trials (rcts) for covid-19, which have been published rapidly and in vast numbers, is challenging during a pandemic.Objective to evaluate the robustness of statistically significant findings from rcts for covid-19 using the fragility index.Design, setting, and participants this cross-sectional study included covid-19 trial articles that randomly assigned patients 1:1 into 2 parallel groups and reported at least 1 binary outcome as significant in the abstract.A systematic search was conducted using pub med to identify rcts on covid-19 published until august 7, 2021.Exposures trial characteristics, such as type of intervention (treatment drug, vaccine, or others), number of outcome events, and sample size.Main outcomes and measures fragility index.Results of the 47 rcts for covid-19 included, 36 (77%) were studies of the effects of treatment drugs, 5 (11%) were studies of vaccines, and 6 (13%) were of other interventions.A total of 138 235 participants were included in these trials.The median (iqr) fragility index of the included trials was 4 (1-11).The medians (iqrs) of the fragility indexes of rcts of treatment drugs, vaccines, and other interventions were 2.5 (1-6), 119 (61-139), and 4.5 (1-18), respectively.The fragility index among more than half of the studies was less than 1% of each sample size, although the fragility index as a proportion of events needing to change would be much higher.Conclusions and relevance this cross-sectional study found a relatively small number of events (a median of 4) would be required to change the results of covid-19 rcts from statistically significant to not significant.These findings suggest that health care professionals and policy makers should not rely heavily on individual results of rcts for covid-19.

Journal: JAMA network open (2022)
Publication types: Journal Article;Systematic Review
Frontal plane pelvic motion during gait captures hip osteoarthritis related disability.

Gait analysis has widely been accepted as an objective measure of function and clinical outcome.Ambulatory accelerometer-based gait analysis has emerged as a clinically more feasible alternative to optical motion capture systems but does not provide kinematic characterisation to identify disease dependent mechanisms causing walking disability.This study investigated the potential of a single inertial sensor to derive frontal plane motion of the pelvis (i.e.Pelvic obliquity) and help identify hip osteoarthritis (oa) related gait alterations.Patients with advanced unilateral hip oa (n = 20) were compared to patients with advanced unilateral knee oa (n = 20) and to a healthy control group (n = 20).Kinematic characterisation of frontal plane pelvic motion during gait demonstrated decreased range of motion and increased asymmetry for hip oa patients specifically.

Journal: Hip international : the journal of clinical and experimental research on hip pathology and therapy (2015)
Publication types: Comparative Study;Journal Article;Research Support, Non-U.S. Gov't
Introduction to the Clinical Forum: Exploring Curriculum-Based Language Assessment and Interventions.

The purpose of this article is to introduce the clinical forum: exploring curriculum-based language assessment and interventions, which investigates the current evidence supporting curriculum-based language intervention and assessment.Method this introduction highlights the need for speech-language pathologists to approach intervention with knowledge of the best evidence available and highlights the 6 articles presented in this clinical forum.Conclusion the articles in this clinical forum shed light on the current state of the evidence for curriculum-based language intervention and assessment across the educational continuum.Authors provide readers with access to techniques available to all school-based speech-language pathologists to advocate for, assess, and implement interventions within the classroom curriculum.This forum also establishes the need for more data to support current school-based models of assessment and intervention.

Journal: Language, speech, and hearing services in schools (2018)
Publication types: Introductory Journal Article
Comorbidities in Recent-Onset Adult Type 1 Diabetes: A Comparison of German Cohorts.

S restrictive exclusion criteria from different study populations may limit the generalizability of the observations.By comparing two differently designed german cohorts, we assessed the prevalence of cardiovascular risk factors and diabetes-related complications in recent-onset adult type 1 diabetes.Methods this study evaluated 1511 persons with type 1 diabetes of the prospective diabetes follow-up registry (dpv) and 268 volunteers of the prospective observational german diabetes study (gds) with a known diabetes duration <1 year.Participants had similar age (36 years), sex distribution (41% female) and bmi (26 kg/m2) in both cohorts.Results the average hb a1c was 6.4 ± 0.8% in the gds and 7.0 ± 1.1% in the dpv.Prevalence of hypertension (24%) was similar, while more dpv participants had dyslipidemia and lipid-lowering medication than gds participants (77% vs.41% and 7% vs.2%, respectively; p<0.05).Prevalence of retinopathy and nephropathy was higher in dpv compared to gds participants (10% vs.3% and 18% vs.7%, respectively; p<0.001).Conclusions diabetic nephropathy and retinopathy are the most frequent complications in type 1 diabetes, affecting up to every 10th patient within the first year after diagnosis, underlining the need for more stringent risk factor management already at the time of diagnosis of type 1 diabetes.

Journal: Frontiers in endocrinology (2022)
Publication types: Journal Article;Observational Study;Research Support, Non-U.S. Gov't
An overview ofSalmonella entericametal homeostasis pathways during infection.

Nutritional immunity is a powerful strategy at the core of the battlefield between host survival and pathogen proliferation.A host can prevent pathogens from accessing biological metals such as mg, fe, zn, mn, cu, co or ni, or actively intoxicate them with metal overload.While the importance of metal homeostasis for the enteric pathogen salmonella enterica typhimurium was demonstrated many decades ago, inconsistent results across various mouse models, diverse salmonellagenotypes, and differing infection routes challenge aspects of our understanding of this phenomenon.With expanding access to crispr-cas9 for host genome manipulation, it is now pertinent to re-visit past results in the context of specific mouse models, identify gaps and incongruities in current knowledge landscape of salmonellahomeostasis, and recommend a straight path forward towards a more universal understanding of this historic host-microbe relationship.

Journal: microLife (2021)
Publication types: Journal Article
Revealing hidden defects through stored energy measurements of radiation damage.

With full knowledge of a material's atomistic structure, it is possible to predict any macroscopic property of interest.In practice, this is hindered by limitations of the chosen characterization techniques.For example, electron microscopy is unable to detect the smallest and most numerous defects in irradiated materials.Instead of spatial characterization, we propose to detect and quantify defects through their excess energy.Differential scanning calorimetry of irradiated ti measures defect densities five times greater than those determined using transmission electron microscopy.Our experiments also reveal two energetically distinct processes where the established annealing model predicts one.Molecular dynamics simulations discover the defects responsible and inform a new mechanism for the recovery of irradiation-induced defects.The combination of annealing experiments and simulations can reveal defects hidden to other characterization techniques and has the potential to uncover new mechanisms behind the evolution of defects in materials.

Journal: Science advances (2022)
Publication types: Journal Article
Fabrication of magnetically separable ruthenium nanoparticles decorated on channelled silica microspheres: Efficient catalysts for chemoselective hydrogenation of nitroarenes.

Fe3o4-si o2microspheres were synthesized by a three-step synthetic procedure involving silica coating, surface capping, and surface modification.These magnetic mesoporous microspheres were employed as sorbents for the incorporation of ultrasmall ru nanoparticles (2-5 nm) followed by thermal aggregation of the microspheres for achieving better heterogeneity and low leaching.The ru decorated fe3o4-si o2microspheres (ru@fe3o4-csm) were applied as chemoselective catalysts to convert more than 20 substituted nitroarenes to corresponding amines with good-to-excellent conversion (77-99%) and selectivity (70-100%) under mild conditions; the catalyst can be magnetically recovered within a frame of 90s (recovery time-lapse) and reused up to 5 times without significant decrease in activity or selectivity.Magnetic hysteresis studies were performed to elucidate the magnetic behavior of the ruthenium decorated materials.

Journal: Dalton transactions (Cambridge, England : 2003) (2021)
Publication types: Journal Article
Genetically Modified Micro-Organisms for Industrial Food Enzyme Production: An Overview.

The use of food enzymes (fe) by the industrial food industry is continuously increasing.These fe are mainly obtained by microbial fermentation, for which both wild-type (wt) and genetically modified (gm) strains are used.The fe production yield can be increased by optimizing the fermentation process, either by using genetically modified micro-organism (gmm) strains or by producing recombinant enzymes.This review provides a general overview of the different methods used to produce fe preparations and how the use of gmm can increase the production yield.Additionally, information regarding the construction of these gmm strains is provided.Thereafter, an overview of the different european regulations concerning the authorization of fe preparations on the european market and the use of gmm strains is given.Potential issues related to the authorization and control of fe preparations sold on the european market are then identified and illustrated by a case study.This process highlighted the importance for control of fe preparations and the consequent need for appropriate detection methods targeting the presence of gmm, which is used in fermentation products.

Journal: Foods (Basel, Switzerland) (2020)
Publication types: Journal Article;Review
Early Warning Factors of Death in COVID-19 Patients.

The infectious coronavirus disease 2019 (covid-19) has spread all over the world and been persistently evolving so far.The number of deaths in the whole world has been rising rapidly.However, the early warning factors for mortality have not been well ascertained.In this retrospective, single-centre cohort study, we included some adult inpatients (≥18 years old) with laboratory-confirmed covid-19 from renmin hospital of wuhan university who had been discharged or had died by apr.8, 2020.Demographic, clinical and laboratory data at admission were extracted from electronic medical records and compared between survivors and non-survivors.We used univariable analysis, cox proportional hazard model analysis and receiver operating characteristic (roc) curve to explore the early warning factors associated with in-hospital death.A total of 159 patients were included in this study, of whom 86 were discharged and 73 died in hospital.Hypertension (52.1% vs.29.1%, p=0.003) and coronary heart disease (28.8% vs.12.8%, p=0.012) were more frequent among non-survived patients than among survived patients.The proportions of patients with dyspnoea (67.1% vs.25.6%, p<0.001), chest distress (58.9% vs.26.7%, p<0.001) and fatigue (64.4% vs.25.6%, p<0.001) were significantly higher in the non-survived group than in the survived group.Regression analysis with the cox proportional hazards mode revealed that increasing odds of in-hospital death were associated with higher il-6 (odds ratio 10.87, 95% ci 1.41-83.59; p=0.022), lactate (3.59, 1.71-7.54; p=0.001), older age (1.86, 1.03-3.38; p=0.041) and lower lymphopenia (5.44, 2.71-10.93; p<0.001) at admission.The areas under the roc curve (aucs) of il-6, lymphocyte, age and lactate were 0.933, 0.928, 0.786 and 0.753 respectively.The auc of il-6 was significantly higher than that of age (z=3.332, p=0.0009) and lactate (z=4.441, p<0.0001) for outcome prediction.There was no significant difference between the aucs of il-6 and lymphocyte for outcome prediction (z=0.372, p=0.7101).It was concluded that the potential risk factors of higher il-6, lactate, older age and lower lymphopenia at admission could help clinicians to identify patients with poor prognosis at an early stage.

Journal: Current medical science (2021)
Publication types: Journal Article
In VivoPhotocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M.

Photoswitchable reagents are powerful tools for high-precision studies in cell biology.When these reagents are globally administered yet locally photoactivated in two-dimensional (2d) cell cultures, they can exert micron- and millisecond-scale biological control.This gives them great potential for use in biologically more relevant three-dimensional (3d) models andin vivo, particularly for studying systems with inherent spatiotemporal complexity, such as the cytoskeleton.However, due to a combination of photoswitch isomerization under typical imaging conditions, metabolic liabilities, and insufficient water solubility at effective concentrations, thein vivopotential of photoswitchable reagents addressing cytosolic protein targets remains largely unrealized.Here, we optimized the potency and solubility of metabolically stable, druglike colchicinoid microtubule inhibitors based on the styrylbenzothiazole (sbt) scaffold that are nonresponsive to typical fluorescent protein imaging wavelengths and so enable multichannel imaging studies.We applied these reagents both to 3d organoids and tissue explants and to classic model organisms (zebrafish, clawed frog) in one- and two-protein imaging experiments, in which spatiotemporally localized illuminations allowed them to photocontrol microtubule dynamics, network architecture, and microtubule-dependent processesin vivowith cellular precision and second-level resolution.These nanomolar,in vivocapable photoswitchable reagents should open up new dimensions for high-precision cytoskeleton research in cargo transport, cell motility, cell division, and development.More broadly, their design can also inspire similarly capable optical reagents for a range of cytosolic protein targets, thus bringingin vivophotopharmacology one step closer to general realization.

Journal: Journal of the American Chemical Society (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't