syedzayyan/paper_mill_benchmark huggingface dataset:
An Adjusted Frequency-Domain Algorithm for Arc Array Bistatic SAR Data with One-Moving Transmitter.

Arc array synthetic aperture radar (aa-sar), which can observe the scene in all directions, breaks through the single view of traditional sar.However, the concealment of aa-sar is poor.To mitigate this, arc array bistatic sar (aa-bi sar) with the moving transmitter is proposed, it has the advantages of good concealment and can expand the imaging scene, and improve the flexibility of the system.The imaging geometry including the signal model is established, and a range frequency-domain algorithm based on keystone transform (kt) is proposed in this paper.In the first step, the slant range equation is approximated by taylor series expansion to compensate for the residual phase caused by the transmitter motion.In the second step, the range cell migration between the range and azimuth is eliminated through the kt method in the range frequency-domain.In the third step, using the data after range cell migration correction in step 2, an azimuth pulse compression is performed to obtain the focused image.In addition, the spatial resolution of the aa-bi sar system is analyzed in detail.Finally, three simulation results verify the effectiveness of the proposed algorithm and the change in the spatial resolution.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article
Costs of mass drug administration for scabies in Fiji.

In 2019, the murdoch children's research institute in partnership with the fiji ministry of health and medical services carried out an integrated mass drug administration (mda) for the treatment of scabies and lymphatic filariasis in the northern division of fiji (population estimate 131,914).We conducted a retrospective micro-costing exercise focused on the cost of scabies control in order to inform budgeting and policy decision making in an endemic setting.We collected detailed information on financial and economic costs incurred by both parties during the course of the mda campaign (april 2018 to july 2019).We also conducted interviews with personnel involved in the financial administration of the mda campaign.The economic cost of delivering two doses of ivermectin was us$4.88 per person.The cost of donated drugs accounted for 36.3% of total mda costs.In this first large-scale mda for the public health control of scabies, the estimated cost of delivering mda per person for scabies was considerably more expensive than the costs reported for other neglected tropical diseases.The important cost drivers included the remuneration of health care workers who were extensively involved in the campaign, coverage of hard-to-reach, mainly rural populations and the two-dose regimen of ivermectin.These results highlight the importance of these cost determinants and can be used to plan current and future mda programs.

Journal: PLoS neglected tropical diseases (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Functional characterization of two homologs of yeast acetyl-coenzyme A synthetase in the entomopathogenic fungus Beauveria bassiana.

Acetyl-coenzyme a (co a) synthetase (acs) links cellular metabolism and physiology by catalyzing acetate and co a into acetyl-co a.However, the biological roles of acs are not well studied in entomopathogenic fungi.In this study, two acs proteins (bb acs1 and bb acs2) was functionally characterized in the filamentous insect pathogenic fungus beauveria bassiana.Bb acs1 and bb acs2 localize in cytoplasm and peroxisome, respectively.Bb acs1 contributes to vegetative growth on fatty acids as carbon source, and bb acs2 did not.Both genes did not contribute to fungal response to stresses.The bb acs1 loss conferred a slight influence on conidiation, and did not result in the defects in blastospore formation.On the contrary, bb acs2 significantly contributes to lipid metabolism in germlings, blastospore formation, and virulence.The results indicated that acs2 played a more predominant role than acs1 in b.Bassiana, which links the acetyl-co a metabolism with the lifestyle of entomopathogenic fungi.

Journal: Archives of microbiology (2022)
Publication types: Journal Article
Black-blood thrombus imaging (BTI): a contrast-free cardiovascular magnetic resonance approach for the diagnosis of non-acute deep vein thrombosis.

﻿deep vein thrombosis (dvt) is a common but elusive illness that can result in long-term disability or death.Accurate detection of thrombosis and assessment of its size and distribution are critical for treatment decision-making.In the present study, we sought to develop and evaluate a cardiovascular magnetic resonance (cmr) black-blood thrombus imaging (bti) technique, based on delay alternating with nutation for tailored excitation black-blood preparation and variable flip angle turbo-spin-echo readout, for the diagnosis of non-acute dvt.﻿ methods: this prospective study was approved by institutional review board and informed consent obtained from all subjects.Bti was first conducted in 11 healthy subjects for parameter optimization and then conducted in 18 non-acute dvt patients to evaluate its diagnostic performance.Two clinically used cmr techniques, contrast-enhanced cmr venography (ce-mrv) and three dimensional magnetization prepared rapid acquisition gradient echo (mprage), were also conducted in all patients for comparison.All images obtained from patients were analyzed on a per-segment basis.Using the consensus diagnosis of ce-mrv as the reference, the sensitivity (se), specificity (sp), positive and negative predictive values (ppv and npv), and accuracy (acc) of bti and mprage as well as their diagnostic agreement with ce-mrv were calculated.Besides, diagnostic confidence and interreader diagnostic agreement were evaluated for all three techniques.Results bti with optimized parameters effectively nulled the venous blood flow signal and allowed directly visualizing the thrombus within the black-blood lumen.Higher se (90.4% vs 67.6%), sp (99.0% vs.97.4%), ppv (95.4% vs.85.6%), npv (97.8% vs 92.9%) and acc (97.4% vs.91.8%) were obtained by bti in comparison with mprage.Good diagnostic confidence and excellent diagnostic and interreader agreements were achieved by bti, which were superior to mprage on detecting the chronic thrombus.Conclusion bti allows direct visualization of non-acute dvt within the dark venous lumen and has the potential to be a reliable diagnostic tool without the use of contrast medium.

Journal: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance (2017)
Publication types: Comparative Study;Journal Article;Validation Study
Microbial Pretreatment of Chicken Feather and Its Co-digestion With Rice Husk and Green Grocery Waste for Enhanced Biogas Production.

To utilize wastes and residues sustainably and excellently, there is a need to fend for efficient methods and resources for biogas production.Use of poultry waste for biogas production represents one of the most important routes toward reaching global renewable energy targets.The current study involves microbial pretreatment of chicken feather waste, followed by its co-digestion with rice husk and green grocery waste in batch and continuous reactors, respectively.Microbial pretreatment of chicken feathers by keratinase secreting pseudomonas aeruginosawas an effective and eco-friendly approach to make its recalcitrant structure available as a raw substrate for biogas production.The current study also addressed the enhancement and stability of anaerobic digestion by co-digestion.Results demonstrated that biogas production was increased by microbial pretreatment of chicken feathers and that the percentage increase in biogas yield was 1.1% in microbialy pretreated feathers compared to mono-digestion (non-pretreated feathers) in batch fermentation.The highest yield of biogas was obtained in a batch reactor having co-digestion of pretreated rice husk and microbial pretreated chicken feathers.The co-digestion of chicken feathers hydrolysate with green grocery waste in continuous fermentation mode has also enhanced the biogas yield as compared to average of mono-digestion (chicken feather hydrolysate and green grocery waste) and, therefore, improve the efficiency of the overall process.

Journal: Frontiers in microbiology (2022)
Publication types: Journal Article
Advances in endovascular therapy for ischemic cerebrovascular diseases.

Endovascular therapy for ischemic cerebrovascular diseases has developed rapidly in recent years.The latest clinical trials of acute ischemic stroke have shown promising results with the continued advancement of concepts, techniques, and materials.Mechanical thrombectomy is recommended in the treatment of acute ischemic stroke caused by large vessel occlusion of the anterior circulation, according to the guidelines updated in europe, usa, and china.The long-term therapeutic efficacy of endovascular stenting for carotid artery stenosis has also been proved noninferior to that of carotid endarterectomy.However, the latest clinical trials have shown that the efficacy of stenting for intracranial artery and vertebral artery stenosis is inferior to that of medical treatment alone, which needs urgent attention through further development and studies.

Journal: Chronic diseases and translational medicine (2016)
Publication types: Journal Article;Review
In-vitro cytotoxicity of nickel oxide nanoparticles against L-6 cell-lines: MMP, MTT and ROS studies.

In the present work we synthesize nickel oxide nanoparticles (ni o nps) using rhododendron arboretum (flower) (rni), tinospora cordifolia (stems) (gni), corylus jacquemontii (seeds) (cni), and nardostachys jatamansi (roots) (nni) extracts by co-precipitation method.The synthesized ni o nps were characterized in detail in terms of their morphological, crystalline nature, structural and antiproliferative activity against rat skeletal myoblast (l-6) cell lines.Morphological studies confirmed the formation of nanoparticles, while the structural and compositional characterization revealed the well-crystallinity and high purity of the synthesized nanoparticles.For biological applications and cytotoxicity examinations of the synthesized nps, the rat skeletal myoblast (l-6) cell lines were subjected to study.By detailed cytotoxic investigations, it was observed that among the four kinds of ni o nps prepared through different plant extracts, the tinospora cordifolia (stems) showed strong antiproliferative activity against rat skeletal myoblast (l-6) cell lines and the calculated ic50was 1.671 mg/m l.The observed antiproliferative activity towards different ni o nps were in the order of gni > nni > rni > cni.The present studies demonstrate that simply synthesized ni o can efficiently be used as antiproliferative agents.

Journal: Environmental research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Mitochondrial developmental encephalopathy with bilateral optic neuropathy related to homozygous variants in IMMT gene.

Immt gene codes for mitofilin, a mitochondrial inner membrane protein that regulates the morphology of mitochondrial cristae.The phenotype associated with mutations in this gene has not been yet established, but functional studies carried out show that its loss causes a mitochondrial alteration, both in the morphology of the mitochondrial crests and in their function.We present two cousins from an extended highly consanguineous family with developmental encephalopathy, hypotonia, nystagmus due to optic neuropathy.The likely pathogenic homozygous c.895a>g (p.lys299glu) variant in the immt gene co-segregates with the disease and associates altered mitochondrial cristae observed by electron microscopy.

Journal: Clinical genetics (2022)
Publication types: Case Reports;Journal Article;Research Support, Non-U.S. Gov't
Integrated Omics analysis of pig muscle metabolism under the effects of dietary Chlorella vulgaris and exogenous enzymes.

Monogastric feeding is dependent on costly conventional feedstuffs.Microalgae such as chlorella vulgaris are a sustainable alternative; however, its recalcitrant cell wall hinders monogastric digestion.Carbohydrate active enzyme (cazyme) supplementation is a possible solution.The objective of this work was to evaluate the effect of 5% dietary c.Vulgaris (cv) and enzymatic supplementation (cv + r-rovabio® excel ap; cv + m-four cazyme mix) on muscle transcriptome and proteome of finishing pigs, in an integrated approach.Control pigs increased the abundance of contractile apparatus (myh1, myh2, myh4) and energy metabolism (ckmt1, ndufs3) proteins, demonstrating increased nutrient availability.They had increased expression of scd, characteristic of increased glucose availability, via the activation of srebp-1c and ch rebp.Cv and cv + r pigs upregulated proteolytic and apoptotic genes (bax, dda1), whilst increasing the abundance of glucose (uqcrfs1) and fatty acid catabolism (acads) proteins.Cv + r pigs upregulated acot8 and sirt3 genes as a response to reduced nutrient availability, maintaining energy homeostasis.The cell wall specific cazyme mix, cv + m, was able to comparatively reduce omics alterations in the muscle, thereby reducing endogenous nutrient catabolism compared to the cv + r and cv.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Impact of Co-Administration of N-Acetylcysteine and Vitamin E on Cyclophosphamide-Induced Ovarian Toxicity in Female Rats.

Cyclophosphamide is used to treat various types of cancer.However, it can reduce ovarian function and fertility rate.The current study was done to compare the effects of n-acetylcysteine and vitamin e on cyclophosphamide-induced ovarian damage.Thirty-five rats were randomly divided into 5 groups: control (c), cyclophosphamide (cp, 200 mg/kg single dose intraperitoneally), t1 (cyclophosphamide + vitamin e at 200 mg/kg), t2 (cyclophosphamide + 200 mg/kg n-acetylcysteine), and t3 (cyclophosphamide + n-acetylcysteine and vitamin e at 200 mg/kg).The main measurements included total antioxidant capacity (tac), glutathione peroxidase (gpx), malondialdehyde (mda), interleukin 8 (il-8), tumor necrosis factor-α(tnfα), follicle stimulating hormone (fsh), luteinizing hormone (lh), and estrogen (es).Except for the c and t3 groups, the other groups lost weight.A significantly lower concentration of mda was observed in the t3 group.However, tac was substantially increased compared to the other groups.The level of gpx in the s group was significantly reduced compared to all groups.Proinflammatory markers (il-8 and tnfα) reached their lowest serum level in the t3 group, with a statistically significant difference compared to that of the s group.In addition, there were no significant differences in the means of primary, secondary, and graph and atretic follicles between the t3 and c group.On the other hand, a decrease in fsh and lh was observed while an increase in es was seen in the t3 group compared to the s group.This study revealed that n-acetylcysteine and vitamin e coadministration could significantly decrease the side effects of cyclophosphamide, especially in ovarian tissue.

Journal: Journal of toxicology (2022)
Publication types: Journal Article
Contribution of microalgae to carbon sequestration in a natural karst wetland aquatic ecosystem: An in-situ mesocosm study.

Carbonate rock weathering coupled with aquatic photosynthesis in karst areas is an important part in the formation of terrestrial carbon sinks.The capacity of photosynthetic carbon sequestration by aquatic microalgae and carbonic anhydrase (ca) is integral in the estimation of carbon sink potential of karst aquatic ecosystems.To date, carbon sequestration by aquatic microalgae in karst areas has been investigated in laboratory experiments.In the present work, the capacity of carbon sequestration by microalgae and ca under natural karst aquatic conditions and the main environmental factors were investigated in field in-situ mesocosms.The sizhitan pond of the huixian karst wetland in guilin city, guangxi province, china, was selected as a typical karst natural water body for this study.The capacity of photosynthetic carbon sequestration varied with microalgal community composition.The microalgal communities with active extracellular ca showed high capacity of carbon sequestration.The average conversion of inorganic carbon to relatively stable organic carbon by microalgae in the huixian karst wetland aquatic ecosystem was estimated as 4207.5 t c/a.Approximately 28.7% of the bicarbonate fed by the karst underground river was fixed into organic carbon by microalgal photosynthesis.The major environmental factors affecting the capacity of carbon sequestration by microalgae in the karst wetland aquatic ecosystem were the water ca activity, illumination, temperature, total phosphorus and total nitrogen.This study is the first to address the contribution of aquatic microalgae and ca to carbon sequestration under natural karst aquatic conditions.The findings contribute to establishing groundwork for substantiating the carbon sink potential in global karst ecosystems.

Journal: The Science of the total environment (2021)
Publication types: Journal Article
Validation of sonographic assistance for placement of a nasogastric tube in pediatric patients.

Enteral access via nasogastric tube (ngt) placement can be essential in the provision of care in pediatric patients.Methods exist to confirm correct placement with success rates between 80% and 85%.Radiographic confirmation remains the "gold-standard," however; it exposes patients to ionizing radiation and fails to provide "real-time" information.In this study, we determined the feasibility of using sonography to assist in the placement of ngt insertions in pediatric patients that have difficulty cooperating.Methods thirty patients requiring ngt placement were stratified into three age groups.Upon ngt insertion, transverse and longitudinal ultrasound images were acquired to visualize tube progression through the esophagus.Subsequently, a focused ultrasonographic exam of the gastric antrum and body were performed.If amenable, an air bolus (1 m l/kg) was injected in the stomach if the ngt was not directly visualized.Following intubation, standard guidelines for ngt position confirmation were performed.Results the ngt was visualized in all esophageal views and 52% of gastric views.Subgroup analysis showed that successful visualization of tube placement in the stomach ranged from 40% (7-18 years) to 70% (3-6 years).Eighty percentage of air boluses injected were visualized.Conclusion the use of ultrasonography may assist ngt placement in pediatric patients and reduce the incidence of suboptimal placement during insertion.We demonstrated successful ngt visualization through the esophagus regardless of age.Ngt visualization in the stomach was challenging; however, injection of an air bolus may improve visualization.Further studies are required to improve the success rate of obtaining gastric views of the ngt.

Journal: Journal of clinical ultrasound : JCU (2021)
Publication types: Journal Article;Validation Study
The influence of interferon on healthy and diseased skin.

Type i interferons (ifns) are an immunomodulatory class of cytokines that serve to protect against viral and bacterial infection.In addition, mounting evidence suggests ifns, particularly type i but also ifnγ, are important to the pathogenesis of autoimmune and inflammatory skin diseases, such as cutaneous lupus erythematosus (cle).Understanding the role of ifns is relevant to anti-viral responses in the skin, skin biology, and therapeutics for these ifn-related conditions.Type i ifns (α and β) are produced by recruited inflammatory cells and by the epidermis itself (ifnκ) and have important roles in autoimmune and inflammatory skin disease.Here, we review the current literature utilizing a pub med database search using terms [interferon/ifn/type i ifn and lupus/ cutaneous lupus/cle/dermatomyositis/sjogrens/psoriasis/lichen planus/morphea/alopecia areata/vitiligo] with a focus on the role of ifns in basic keratinocyte biology and their implications in the cutaneous autoimmune and inflammatory diseases: cutaneous lupus erythematosus, dermatomyositis, sjogren's syndrome, psoriasis, lichen planus, alopecia areata and vitiligo.We provide information about genes and proteins induced by ifns and how downstream mechanisms relate to clinical disease.

Journal: Cytokine (2020)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Review
Effects of cationic adjuvant formulation particle type, fluidity and immunomodulators on delivery and immunogenicity of saRNA.

Self-amplifying rna (sa rna) is well suited as a vaccine platform against chlamydia, as it is relatively affordable and scalable, has been shown to induce immunity against multivalent antigens, and can result in protein expression for up to 60 days.Cationic adjuvant formulations (cafs) have been previously investigated as an adjuvant for protein subunit vaccines; here we optimize the cafs for delivery of sa rna in vivo and observe the immunogenicity profile in the context of both cellular and humoral immunity against the major outer membrane protein (momp) of chlamydia trachomatis.We tested both liposomal and emulsion based cafs with solid and fluid phase lipids, with or without the tlr agonists r848 and 3m-052, for in vitro transfection efficiency and cytotoxicity.We then optimized the rna/delivery system ratio for in vivo delivery using sa rna coding for firefly luciferase (f luc) as a reporter protein in vivo.We observed that while the fluid phase liposome formulations showed the highest in vitro transfection efficiency, the fluid and solid phase liposomes had equivalent luciferase expression in vivo.Incorporation of r848 or 3m-052 into the formulation was not observed to affect the delivery efficiency of sa rna either in vitro or in vivo.Momp-encoding sa rna complexed with cafs resulted in both momp-specific cellular and humoral immunity, and while there was a slight enhancement of ifn-γ+t-cell responses when r848 was incorporated into the formulation, the self-adjuvanting effects of rna appeared to dominate the immune response.These studies establish that cafs are efficient delivery vehicles for sa rna both for in vitro transfections and in vivo immunogenicity and generate cellular and humoral responses that are proportionate to protein expression.

Journal: Journal of controlled release : official journal of the Controlled Release Society (2019)
Publication types: Comparative Study;Journal Article;Research Support, Non-U.S. Gov't
Structurally regular arrangement induced fluorescence enhancement and specific recognition for glutathione of a pyrene chalcone derivative.

Glutathione (gsh) is an important antioxygen and free radical scavenger in the organism.Level of gsh in vivo is associated with many diseases and specific recognition for gsh is very important.Here, a pyrene chalcone derivative 1 1-(2-hydroxyphenyl)-3-(1-pyrenyl)-2-propen-1-one as specific probe for gsh was developed.The probe can give rise to rapid blue fluorescence enhancement for gsh based on michael addition reaction in pure pbs solution with high sensitivity, fast response rate and high specificity.The compound also can be applied for gsh detection in he la cell.Simultaneously, the compound exhibits blue fluorescence emission enhancement in methanol-water (1:1, v/v) solution with fluorescence quantum yield being 0.45 due to the competition of water molecules for hydrogen bonds between hydroxyl and carbonyl and the formation of structurally regular rodlike crystals, which allows regulating fluorescence emission by different solvent condition.

Journal: Analytica chimica acta (2019)
Publication types: Journal Article