syedzayyan/paper_mill_benchmark huggingface dataset:
Adult Presentation of Subaortic Stenosis with Subaortic Membrane Treated with Surgical Removal.

Subaortic stenosis (sas) is a rare heart disease in adults with an unclear etiology and variable clinical presentation.In some cases, sas appears as hypertrophic cardiomyopathy with obstruction due to the accompanying systolic anterior motion of the mitral valve.A 46-year-old male with dizziness for several months presented in the outpatient department.Two-dimensional transthoracic echocardiography demonstrated a slightly hypertrophic left ventricle with normal systolic function without wall-motion abnormalities.Just below the aortic valve, a linear structure protruding from the septum side and the left-ventricular outflow tract (lvot) side of the mitral valve was confirmed, which was causing a significant pressure gradient (mean and maximum of 91 mm hg and 138 mm hg, respectively).A diagnosis of sas with subaortic membrane was made, and surgical myomectomy and subaortic membrane removal surgery were performed.Postoperative transthoracic echocardiography did not show flow acceleration through the lvot, nor a significant pressure gradient across the aortic valve.This case report highlights the clinical significance of sas with subaortic membrane, which can be confused with aortic stenosis of other etiology.

Journal: Journal of cardiovascular development and disease (2022)
Publication types: Case Reports;Journal Article
Imaginal extinction and the vividness of mental imagery: Exploring the reduction of fear within the mind's eye.

Patients are encouraged to produce vivid mental imagery during imaginal exposure, as it is assumed to promote fear reduction.Nevertheless, the link between fear reduction and imagery vividness is unclear.We investigated the impact of vividness on fear responses using an experimental analogue of imaginal exposure - imaginal extinction - in which conditioned fear, measured with skin conductance, is reduced through exposure to mental imagery of the conditioned stimulus.We examined (1) if task-specific vividness (high vs low) of the conditioned stimulus during imaginal extinction moderated the reduction of fear responses, and (2) if task-specific vividness influenced remaining fear responses 24 h later.Findings suggest that high vividness may be advantageous for fear reduction during imaginal extinction, but it may not influence fear responses in the longer term.A possible clinical implication is that high imagery vividness during imaginal exposure may not be vital for overall treatment outcome.As high vividness is associated with increased levels of distress, a future direction would be to explore whether similar fear reduction can be obtained with less vivid imaginal exposure and thereby make treatment tolerable for more patients.

Journal: Behavioural brain research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Clinical significance of STING expression and methylation in lung adenocarcinoma based on bioinformatics analysis.

The role of stimulator of interferon genes [sting, also known as transmembrane protein 173 (tmem173)] in various human cancers has begun to emerge.However, the clinical value of sting in lung adenocarcinoma (luad) remains elusive.This study aims to elucidate the clinical significance of sting expression and methylation in luad.Here, through analyzing data from public resources, we found that both the m rna and protein expression of sting were reduced in lung cancer.Moreover, lower expression of sting was associated with a worse prognosis in luad, but not lung squamous cell carcinoma (lusc).Of note, higher methylation of sting was found in luad and had the potential to distinguish luad tissues from adjacent non-tumor lung tissues and correlated with unfavorable outcomes.Furthermore, the methylation of sting could serve as an independent prognostic indicator for both the overall survival (os) and disease-free survival (dfs) of luad patients.Additionally, the constructed nomogram exhibited a favorable predictive accuracy in predicting the probability of 1- and 2-year os.Our findings suggest that the m rna expression, and especially the dna methylation of sting, have the potential to be prognostic indicators for luad patients.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Time-controlled fasting prevents aging-like mitochondrial changes induced by persistent dietary fat overload in skeletal muscle.

A large body of evidence suggests that persistent dietary fat overload causes mitochondrial dysfunction and systemic metabolic gridlock.Mitochondrial and lipid metabolism in skeletal muscle (sk m) are severely affected upon persistent high fat diet (hfd) leading to premature tissue aging.Here, we designed weekly cycles of fasting (called as time-controlled fasting, tcf) and showed that they were effective in limiting mitochondrial damage and metabolic disturbances induced by hfd.Specifically, tcf was able to prevent the decline of adipose triglyceride lipase (atgl), maintain efficient mitochondrial respiration in sk m as well as improve blood glucose and lipid profile.Atgl was found to be the mediator of such preventive effects as its downregulation or up-regulation in c2c12 myotubes triggers mitochondrial alteration or protects against the deleterious effects of high fat levels respectively.In conclusion, tcf could represent an effective strategy to limit mitochondrial impairment and metabolic inflexibility that are typically induced by modern western diets or during aging.

Journal: PloS one (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A diagnostic platform for rapid, simultaneous quantification of procalcitonin and C-reactive protein in human serum.

Early and accurate determination of bacterial infections as a potential cause for a patient's systemic inflammatory response is required for timely administration of appropriate treatment and antibiotic stewardship.Procalcitonin (pct) and c-reactive protein (crp) have both been used as biomarkers to infer bacterial infections, particularly in the context of sepsis.There is an urgent need to develop a platform for simultaneous quantification of pct and crp, to enable the potential use of these biomarkers at the point-of-care.Methods a multiplexed lateral flow assay (lfa) and a fluorescence optical reader were developed.Assay performance was validated by testing spiked antigens in the buffer, followed by a validation study comparing results with conventional assays (roche cobas e411 elecsys pct and siemens advia xpt crp) in 25 archived remnant human serum samples.Findings a linear regression correlation of 0·97 (p < 0·01) was observed for pct, and a correlation of 0·95 (p < 0·01) was observed for crp using direct patient samples.We also validated our platform's ability to accurately quantify high-dose crp in the hook effect range where excess unlabeled analytes occupy binding sites at test lines.Interpretation a fluorescence reader-based duplex lfa for simultaneous quantification of pct and crp was developed and successfully validated with clinical samples.The rapid, portable, and low-cost nature of the platform offers potential for differentiation of bacterial and viral infections in emergency and low-resource settings at the point-of-care.Funding nih/nibib award 1r01eb021331, and academic venture fund from the atkinson center for a sustainable future at cornell university.

Journal: EBioMedicine (2022)
Publication types: Journal Article
Membrane cofactor protein (MCP; CD46): deficiency states and pathogen connections.

Membrane cofactor protein (mcp; cd46), a ubiquitously expressed complement regulatory protein, serves as a cofactor for serine protease factor i to cleave and inactivate c3b and c4b deposited on host cells.However, cd46 also plays roles in human reproduction, autophagy, modulating t cell activation and effector functions and is a member of the newly identified intracellular complement system (complosome).Cd46 also is a receptor for 11 pathogens ('pathogen magnet').While cd46 deficiencies contribute to inflammatory disorders, its overexpression in cancers and role as a receptor for some adenoviruses has led to its targeting by oncolytic agents and adenoviral-based therapeutic vectors, including coronavirus disease of 2019 (covid-19) vaccines.This review focuses on recent advances in identifying disease-causing cd46 variants and its pathogen connections.

Journal: Current opinion in immunology (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Review
A Digital Platform for Facilitating Personalized Dementia Care in Nursing Homes: Formative Evaluation Study.

Care personalization is key to the well-being of people with dementia according to person-centered care.With the development of the internet of things, a large quantity of personal data can be collected securely and reliably, which has the potential to facilitate care personalization for people with dementia.Yet, there are limited assistive technologies developed for this purpose, and the user acceptance of assistive technologies is low in nursing homes.Therefore, through a data-enabled design approach, a digital platform was developed for helping the care team in a nursing home to personalize dementia care, specifically in the management of behavioral and psychological dementia symptoms.Objective this study aimed to evaluate the digital platform in a real-life context with potential users from the following two aspects: (1) to explore if the digital platform could help with generating insights on the current state of each person with dementia and (2) to gather feedback on the digital platform from the care team.Methods the digital platform was deployed in the nursing home for 7 weeks and the data collected were visualized and presented to the care team via the digital platform.The visualizations were analyzed by the researchers for pattern detection.Meanwhile, the care team was asked to examine the visualizations and were interviewed for the following: (1) if any insights and actions were generated from the examination, (2) the usefulness of the digital platform, and (3) the improvements they would like to see.Results the data collected on the digital platform demonstrated its potential for pattern detection.Insights were generated by the care team and categorized into "client level," "ward level," and "team level." the corresponding actions taken by the care team were classified into "investigation" and "implementation." user acceptance varied across the care team, and three aspects of improvement for the digital platform were identified.Conclusions by evaluating the digital platform, this study gained insights on applying data-enabled design for personalizing dementia care; besides, it offers future researchers some recommendations on how to integrate assistive technologies in the nursing home context.

Journal: JMIR formative research (2021)
Publication types: Journal Article
Identification of Infigratinib as a Potent Reversible Inhibitor and Mechanism-Based Inactivator of CYP2J2: Nascent Evidence for a Potential In Vivo Metabolic Drug-Drug Interaction with Rivaroxaban.

Infigratinib (inf) is a fibroblast growth factor receptor inhibitor that was recently united states food and drug administration-approved for the treatment of advanced or metastatic cholangiocarcinoma.We previously established that inf inhibited and inactivated cytochrome p450 3a4 (cyp3a4).Here, in a follow up to our previous study, we identified for the first time that inf also elicited potent competitive inhibition and mechanism-based inactivation of cyp2j2 with kinetic parameters ki,ki,kinact, and a partition ratio of 1.94μm, 0.10μm, 0.026 minute-1, and ∼3, respectively, when rivaroxaban was harnessed as the probe substrate.Inactivation was revealed to exhibit cofactor-dependency and was attenuated by an alternative substrate (astemizole) and direct inhibitor (nilotinib) of cyp2j2.Additionally, the nature of inactivation was unlikely to be pseudo-irreversible and instead arose from covalent modification due to the lack of substantial enzyme activity recovery after dialysis and chemical oxidation, as well as the lack of a resolvable soret band in spectral scans.Glutathione trapping confirmed that the identity of the putative reactive intermediate implicated in the covalent inactivation of both cyp2j2 and cyp3a4 was identical and likely attributable to an electrophilicp-benzoquinonediimine intermediate of inf.Finally, mechanistic static modeling revealed that by integrating the previously arcane inhibition and inactivation kinetic parameters of cyp2j2-mediated rivaroxaban hydroxylation by inf illuminated in this work, together with those previously documented for cyp3a4, a 49% increase in the systemic exposure of rivaroxaban was projected.Our modeling results predicted a potential risk of metabolic drug-drug interactions between the clinically relevant combination of rivaroxaban and inf in the setting of cancer.Significance statement: this study reported that inf elicits potent reversible inhibition and mechanism-based inactivation of cyp2j2.Furthermore, static modelling predicted that its coadministration with the direct oral anticoagulant rivaroxaban may potentially culminate in a metabolic drug-drug interaction (ddi) leading to an increased risk of major bleeding.As rivaroxaban is steadily gaining prominence as the anticoagulant of choice in the treatment of cancer-associated venous thromboembolism, the ddi projections reported here are clinically relevant and warrant further investigation via physiologically based pharmacokinetic modelling and simulation.

Journal: The Journal of pharmacology and experimental therapeutics (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Computerized Cognitive Behavioral Therapy Intervention for Depression Among Veterans: Acceptability and Feasibility Study.

Computerized cognitive behavioral therapies (c cbts) have been developed to deliver efficient, evidence-based treatment for depression and other mental health conditions.Beating the blues (bt b) is one of the most empirically supported c cbts for depression.The previous trial of bt b with veterans included regular guidance by health care personnel, which increased the complexity and cost of the intervention.Objective this study, conducted by researchers at a veterans affairs medical center, aims to test the acceptability and feasibility of unguided c cbt for depression among us military veterans.Methods to examine the acceptability of bt b delivered without additional peer or other mental health care provider support, a before-and-after trial was conducted among united states (us) military veterans experiencing mild to moderate depressive symptoms.The feasibility of the study design for a future efficacy trial was also evaluated.Results in total, 49 veterans completed preintervention assessments and received access to bt b, and 29 participants completed all postintervention assessments.The predetermined acceptability criterion for the intervention was met.Although the predetermined feasibility criteria regarding screening eligibility rate, number of bt b modules completed, and completion of a posttreatment assessment were not met, the results were comparable with those of other c cbt studies.Conclusions this is the first study among us military veterans to demonstrate support for the implementation of c cbt for depression without the assistance of a mental health professional or a peer support specialist, suggesting that stand-alone computer-aided interventions may be viable.Ideas for improving feasibility in future trials based on this study are discussed.

Journal: JMIR formative research (2022)
Publication types: Journal Article
Determination of 16 serum angiogenic factors in stage I non-small cell lung cancer using a bead-based multiplex immunoassay.

The aim of the study was to identify significant abnormalities in angiogenic factor profiles occurring at early-stage non-small cell lung cancer (nsclc).Contrary to the previous studies, our research included patients with only stage i nsclc, which allowed for estimating the utility of circulating angiogenic factors in early nsclc detection.The investigation was performed in serum samples collected from individuals with untreated nsclc (n=41) and a matched control group of healthy individuals (n=61).All patients had histopathologically-confirmed stage ia or ib nsclc.Serum concentrations of 16 angiogenesis markers comprising growth factors, receptors, cytokines, chemokines and hormones, were measured using a bead-based multiplex immunoassay.Among the determined proteins, osteopontin, platelet-derived growth factor-ab and -bb (pdgf-ab/bb) and hepatocyte growth factor (hgf) demonstrated the largest increase in concentration in nsclc patients as compared with the non-cancer group.Roc curve analysis confirmed their high discriminatory abilities in detection of early nsclc (auc=0.809, 95%ci 0.725-0.881).Serum levels of the studied angiogenic factors differed slightly between patients with lung adenocarcinoma and squamous cell carcinoma.The study demonstrated that osteopontin, pdgf-ab/bb, and hgf might add up to the methods used in nsclc diagnosis.Future research should address the question about their specificity and performance in early nsclc detection in a combination with various putative lung cancer markers.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2017)
Publication types: Journal Article
Rehabilitation of motor function after stroke: A bibliometric analysis of global research from 2004 to 2022.

And aims the mortality rate of stroke has been increasing worldwide.Poststroke somatic dysfunctions are common.Motor function rehabilitation of patients with such somatic dysfunctions enhances the quality of life and has long been the primary practice to achieve functional recovery.In this regard, we aimed to delineate the new trends and frontiers in stroke motor function rehabilitation literature published from 2004 to 2022 using a bibliometric software.Methods all documents related to stroke rehabilitation and published from 2004 to 2022 were retrieved from the web of science core collection.Publication output, research categories, countries/institutions, authors/cocited authors, journals/cocited journals, cocited references, and keywords were assessed using vosviewer v.1.6.15.0 and cite space version 5.8.The cocitation map was plotted according to the analysis results to intuitively observe the research hotspots.Results overall, 3,302 articles were retrieved from 78 countries or regions and 564 institutions.Over time, the publication outputs increased annually.In terms of national contribution, the united states published the most papers, followed by china, japan, south korea, and canada.Yeungnam university had the most articles among all institutions, followed by emory university, fudan university, and national taiwan university.Jang sung ho and wolf s.l.Were the most productive (56 published articles) and influential (cited 1,121 times) authors, respectively."effect of constraint-induced movement therapy on upper extremity function 3-9 months after stroke: the extremity constraint induced therapy evaluation randomized clinical trial" was the most frequently cited reference.Analysis of keywords showed that upper limbs, fugl-meyer assessment, electromyography, virtual reality, telerehabilitation, exoskeleton, and brain-computer interface were the research development trends and focus areas for this topic.Conclusion publications regarding motor function rehabilitation following stroke are likely to continuously increase.Research on virtual reality, telemedicine, electroacupuncture, the brain-computer interface, and rehabilitation robots has attracted increasing attention, with these topics becoming the hotspots of present research and the trends of future research.

Journal: Frontiers in aging neuroscience (2022)
Publication types: Journal Article;Review
TGFβ activating integrins β6 and β8 are dysregulated in inflammatory skin disease and cutaneous melanoma.

Integrins avβ6 and avβ8 are expressed by keratinocytes and transactivate latent tgfβ.In a murine model, integrin mediated activation of tgfβ has been shown to be critical in maintaining skin homeostasis, specifically playing roles in epidermal retention of langerhans cells and resident memory cells t cells (trm).Objective we examine expression of integrins β6 and β8 in human skin, inflammatory skin disease, benign nevi, and melanoma and hypothesize that integrin expression is dysregulated in disease.Methods using immunohistochemistry, we stained tissue from normal human skin (n = 8), psoriasis (n = 6), atopic dermatitis (n = 6), lichen planus (n = 5), benign nevi (n = 24), and melanoma (n = 25) with anti-integrin β6 and anti-integrin β8 to survey expression pattern.We also performed a retrospective chart review in the melanoma cohort to examine if integrin β6 and β8 expression was associated with increased breslow depth and worse prognostic staging.Results here, we show that human keratinocytes express integrins β6 and β8, similar to murine keratinocytes.We also found that inflammatory skin conditions have increased integrin β6, but not integrin β8 expression.Furthermore, we identified that melanomas have greatly increased expression of integrin β8 compared to nevi.Additionally, high expression of integrin β8 was correlated with greater breslow depth at diagnosis and with worse prognostic staging.Conclusion these findings demonstrate that like murine keratinocytes, human keratinocytes express integrin β6 and β8 under steady state conditions.Moreover, altered integrin expression may participate in the development or maintenance of cutaneous inflammation as well as tumor immune evasion.

Journal: Journal of dermatological science (2022)
Publication types: Journal Article
Superposition mechanism as a neural basis for understanding others.

Social cognition has received much attention in fields such as neuroscience, psychology, cognitive science, and philosophy.Theory-theory (tt) and simulation theory (st) provide the dominant theoretical frameworks for research on social cognition.However, neither theory addresses the matter of how the concepts of "self" and "other" are acquired through the development of human and nonhuman agents.Here, we show that the internal representations of "self" and "other" can be developed in an artificial agent only through the simple predictive learning achieved by deep neural networks with the superposition mechanism we herein propose.That is, social cognition can be achieved without a pre-given (or innate) framework of self and other; this is not assumed (or is at least unclear) in tt and st.We demonstrate that the agent with the proposed model can acquire basic abilities of social cognition such as shared spatial representations of self and other, perspective-taking, and mirror-neuron-like activities of the agent's neural network.The result indicates that the superposition mechanism we propose is a necessary condition for the development of the concepts of "self" and "other" and, hence, for the development of social cognition in general.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Tailoring the SWIR emission of gold nanoclusters by surface ligand rigidification and their application in 3D bioimaging.

The influence of solvent polarity and surface ligand rigidification on the swir emission profile of gold nanoclusters with an anistropic surface was investigated.A strong enhancement of the swir emission band at 1200 nm was observed when measuring in different local environments: in solution, in polymer composites, and in solids.Swirin vivoimaging of mice assisted by deep learning after intravenous administration of these gold nanoclusters provides high definition pseudo-3d views of vascular blood vessels.

Journal: Chemical communications (Cambridge, England) (2022)
Publication types: Journal Article