syedzayyan/paper_mill_benchmark huggingface dataset:
Surgical repair for luxation of the superficial digital flexor tendon using a temporary restraining pin.

S (1) to report the clinical features of luxation of the superficial digital flexor tendon in dogs and (2) to report the outcome and complications of a novel surgical technique where postoperative immobilisation was not used.Materials and methods medical records from one swedish veterinary hospital were retrospectively reviewed for cases of superficial digital flexor tendon treated by the author, between july 2007 and august 2019, where a temporary restraining pin was used as part of the surgical repair.Results twenty-three procedures were performed in 19 dogs.Fourteen of the dogs were shetland sheepdogs with five other breeds represented.Lateral luxation occurred in all but one case.Minor complications occurred in eight cases (35%).Major complications requiring unplanned surgery occurred in three cases (13%).All cases ultimately returned to their pre-injury level of activity.Clinical significance the use of a temporary restraining pin is useful in the surgical repair of superficial digital flexor tendon luxation.All cases were successfully treated without using post-operative immobilisation of the tarsal joint.Plain radiography is unreliable in the identification of morphological defects of the calcaneus.

Journal: The Journal of small animal practice (2021)
Publication types: Journal Article
Regional hippocampal vulnerability in early multiple sclerosis: Dynamic pathological spreading from dentate gyrus to CA1.

Whether hippocampal subfields are differentially vulnerable at the earliest stages of multiple sclerosis (ms) and how this impacts memory performance is a current topic of debate.Method we prospectively included 56 persons with clinically isolated syndrome (cis) suggestive of ms in a 1-year longitudinal study, together with 55 matched healthy controls at baseline.Participants were tested for memory performance and scanned with 3 t mri to assess the volume of 5 distinct hippocampal subfields using automatic segmentation techniques.Results at baseline, ca4/dentate gyrus was the only hippocampal subfield with a volume significantly smaller than controls (p < .01).After one year, ca4/dentate gyrus atrophy worsened (-6.4%, p < .0001) and significant ca1 atrophy appeared (both in the stratum-pyramidale and the stratum radiatum-lacunosum-moleculare, -5.6%, p < .001 and -6.2%, p < .01, respectively).Ca4/dentate gyrus volume at baseline predicted ca1 volume one year after cis (r2= 0.44 to 0.47, p < .001, with age, t2 lesion-load, and global brain atrophy as covariates).The volume of ca4/dentate gyrus at baseline was associated with ms diagnosis during follow-up, independently of t2-lesion load and demographic variables (p < .05).Whereas ca4/dentate gyrus volume was not correlated with memory scores at baseline, ca1 atrophy was an independent correlate of episodic verbal memory performance one year after cis (ß = 0.87, p < .05).Conclusion the hippocampal degenerative process spread from dentate gyrus to ca1 at the earliest stage of ms.This dynamic vulnerability is associated with ms diagnosis after cis and will ultimately impact hippocampal-dependent memory performance.

Journal: Human brain mapping (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Impact of Implant Surface Material and Microscale Roughness on the Initial Attachment and Proliferation of Primary Human Gingival Fibroblasts.

Due to the rising demand for zirconia (zr) based implant systems, it is important to understand the impact of zr and titanium (ti) implants and particularly their topography on soft tissue healing.As human gingival fibroblasts (h gfs) are the predominant cells in peri-implant soft tissue, we focused on examining the effect of implant material and surface roughness on h gfs' initial attachment, growth and the expression of proteins involved in the focal adhesion.H gfs isolated from eight healthy donors were cultured on the following surfaces: smooth titanium machined surface (ti m), smooth zirconia machined surface (zr m), moderately rough titanium surface (sla), or moderately rough zirconia surface (zla) for up to 14 days.The initial attachment of h gfs was evaluated by scanning electron microscopy.Cell proliferation/viability was assessed by cell counting kit 8.Focal adhesion and cytoskeleton were visualized by a focal adhesion staining kit.The gene expression of focal adhesion kinase (fak), α-smooth muscle actin (α-sma), and integrin subunits itg-β1, itg-β4, itg-α4, itg-α5, itg-α6, was evaluated by q pcr.Cell proliferation/viability was slightly decreased by moderately rough surfaces, whereas no effect of surface material was observed.Cell morphology was strikingly different between differently treated surfaces: on machined surfaces, cells had elongated morphology and were attached along the grooves, whereas on moderately rough surfaces, cells were randomly attached.Surface roughness had a more pronounced effect on the gene expression compared to the surface material.The expression of fak, α-sma, itg-β4, itg-α5, and itg-α6 was enhanced by moderately rough surfaces compared to smooth surfaces.Within the limitations of this in vitro study, it can be concluded that the behavior of primary h gfs is primarily affected by surface structure, whereas no apparent advantage of zr over ti could be observed.

Journal: Biology (2021)
Publication types: Journal Article
Tiger 17 and pexiganan as antimicrobial and hemostatic boosters of cellulose acetate-containing poly(vinyl alcohol) electrospun mats for potential wound care purposes.

In this research, we propose to engineer a nanostructured mat that can simultaneously kill bacteria and promote an environment conducive to healing for prospective wound care.Polyvinyl alcohol (pva) and cellulose acetate (ca) were combined at different polymer ratios (100/0, 90/10, 80/20% v/v), electrospun and crosslinked with glutaraldehyde vapor.Crosslinked fibers increased in diameter (from 194 to 278 nm), retaining their uniform structure.Fourier-transform infrared spectroscopy and thermal analyses proved the excellent miscibility between polymers.Ca incorporation incremented the fibers swelling capacity and reduced the water vapor and air permeabilities of the mats, preventing the excessive drying of wounds.The antimicrobial peptide cys-pexiganan and the immunoregulatory peptide tiger 17 were incorporated onto the mats via polyethylene glycol spacer (hydroxyl-peg2-maleimide) and physisorbed, respectively.Time-kill kinetics evaluations revealed the mats effectiveness against staphylococcus aureus and pseudomonas aeruginosa.Tiger 17 played a major role in accelerating clotting of re-calcified plasma.Data reports for the first time the collaborative effect of pexiganan and tiger 17 against bacterial infections and in boosting hemostasis.Cytocompatibility data verified the peptide-modified mats safety.Croslinked 90/10 pva/ca mats were deemed the most promising combination due to their moderate hydrophilicity and permeabilities, swelling capacity, and high yields of peptide loading.

Journal: International journal of biological macromolecules (2022)
Publication types: Journal Article
Adherence to Caloric and Protein Recommendations in Older Hemodialysis Patients: A Multicenter Study.

Hemodialysis (hd) patients are characterized by malnutrition, which adversely affects their survival.The development of malnutrition is influenced, among other factors, by improper diet and the advanced age of patients.The study aimed to assess the nutritional status and adherence to dietary recommendations among older patients.The multicenter study included 179 stable hd patients.The nutritional status was assessed by a 7-point subjective global assessment (sga).Anthropometry and body composition was analyzed.The diet was assessed based on the 3-day food diary and the food frequency questionnaire with 6 answers (ffq-6).Blood laboratory tests were performed.Based on the 7-point sga, malnutrition was diagnosed in 38.5% of hd patients.The decreased content of the muscle tissue (lti < 14 kg/m2) was observed in 70.4% of the examined patients and the decreased concentration of s-albumin was observed in 44.1% of patients.Older patients had significantly lower lti.26% of patients consumed less than 25 kcal/kg body weight and less than 0.8 g protein/kg body weight.Older patients’ diets contained significantly fewer calories.There were significant differences between nutrient intake on a weekday with dialysis, a weekday without dialysis, and a weekend day without dialysis.The lowest intake of nutrients was observed on the day of dialysis.Nutritional education and the determination of whether food is permitted during hemodialysis are necessary to improve patients’ nutrition.

Journal: Nutrients (2022)
Publication types: Journal Article;Multicenter Study
Glycometabolism change during Burkholderia pseudomallei infection in RAW264.7 cells by proteomic analysis.

Burkholderia pseudomallei is a gram-negative intracellular bacterium that causes melioidosis, a life-threatening disease.The interaction of b.Pseudomallei with its host is complicated, and cellular response to b.Pseudomallei infection is still largely unknown.In this study, we aimed to determine host-cell responses to b.Pseudomallei at the proteomics level.We performed proteomic profiling of b.Pseudomallei hnbp001-infected mouse macrophage raw264.7 cells to characterize the cellular response dynamics during infection.Western blot analysis was utilized for the validation of changes in protein expression.Gene ontology (go) and kyoto encyclopedia of genes and genomes (kegg) pathway analyses were conducted using the cluster profiler r package.Compared with the negative control (nc) group, 811 common proteins varied over time, with a cut-off level of two fold change and an adjusted p-value less than 0.05.The bioinformatics analysis revealed that the proteins significantly changed in the b.Pseudomallei hnbp001 infection group (bp group) were enriched in glycometabolism pathways, including glycolysis, fructose and mannose metabolism, pentose phosphate pathway, galactose metabolism, and carbon metabolism.Western blot analysis verified three selected proteins involved in glycometabolism pathways, namely pgm1, pkm, and pgk1 were increase over time post the infection.Furthermore, in vitro functional analysis revealed an increased glucose uptake and decreased atp production and o-glc nacylation in the bp group compared with control group, suggesting that b.Pseudomallei hnbp001 infection induces changes in glycometabolism in raw264.7 cells.These results indicate that glycometabolism pathways change in raw264.7 cells post b.Pseudomallei hnbp001 infection, providing important insights into the intimate interaction between b.Pseudomallei and macrophages.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The brain integrates proprioceptive information to ensure robust locomotion.

Robust locomotion relies on information from proprioceptors: sensory organs that communicate the position of body parts to the spinal cord and brain.Proprioceptive circuits in the spinal cord are known to coarsely regulate locomotion in the presence of perturbations.Yet, the regulatory importance of the brain in maintaining robust locomotion remains less clear.Here, through mouse genetic studies and in vivo electrophysiology, we examined the role of the brain in integrating proprioceptive information during perturbed locomotion.The systemic removal of proprioceptors left the mice in a constantly perturbed state, similar to that observed during mechanically perturbed locomotion in wild-type mice and characterised by longer and less accurate synergistic activation patterns.By contrast, after surgically interrupting the ascending proprioceptive projection to the brain through the dorsal column of the spinal cord, wild-type mice showed normal walking behaviour, yet lost the ability to respond to external perturbations.Our findings provide direct evidence of a pivotal role for ascending proprioceptive information in achieving robust, safe locomotion.Key points: whether brain integration of proprioceptive feedback is crucial for coping with perturbed locomotion is not clear.We showed a crucial role of the brain for responding to external perturbations and ensure robust locomotion.We used mouse genetics to remove proprioceptors and a spinal lesion model to interrupt the flow of proprioceptive information to the brain through the dorsal column in wild-type animals.Using a custom-built treadmill, we administered sudden and random mechanical perturbations to mice during walking.External perturbations affected locomotion in wild-type mice similar to the absence of proprioceptors in genetically modified mice.Proprioceptive feedback from muscle spindles and golgi tendon organs contributed to locomotor robustness.Wild-type mice lost the ability to respond to external perturbations after interruption of the ascending proprioceptive projection to the brainstem.

Journal: The Journal of physiology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Magnetic coupling N self-doped porous carbon derived from biomass with broad absorption bandwidth and high-efficiency microwave absorption.

Nowadays, developing microwave absorption materials (mams) with thin thickness, wide-frequency effective absorption bandwidth (eab) and strong absorbing capacity is an urgent requirement to tackle the increasingly serious electromagnetic radiation issue.Herein, we report a novel high-performance mams by growing fe3o4nanoparticles on activated porous carbon derived from egg white via a facile carbonization and subsequent hydrothermal approach.The resultant composite features three-dimensional hierarchical porous carbon embedded with fe3o4nanoparticles.Benefiting from the balanced impedance matching and the multi-loss that involve the conductive loss, dielectric loss, dipolar/interfacial polarization loss and magnetic loss, the prepared composite achieves a minimum reflection loss (rl) of -43.7 d b at 9.92 ghz and a broad eab (rl < -10 d b) of 7.52 ghz (6.24-13.76 ghz) at a thin thickness of 2.5 mm and a low filler content of 20 wt%.This work provides new insights for exploring novel magnetic coupling porous carbon derived from biomass with high-efficiency microwave absorption performance.

Journal: Journal of colloid and interface science (2022)
Publication types: Journal Article
Chemotherapy-Induced Toxicities and Their Associations with Clinical and Non-Clinical Factors among Breast Cancer Patients in Vietnam.

Understanding the burden and factors related to chemotherapy-induced toxicity is important in treatment planning for breast cancer patients.We conducted a prospective study among 396 newly diagnosed and chemotherapy-treated breast cancer patients recruited in two major cancer hospitals in northern vietnam.Toxicities were captured through medical chart reviews and patient self-reports and graded using nci ctcae classification.Associations for sociodemographic and clinical factors with chemotherapy-induced toxicities during first-line chemotherapy were evaluated via multivariable logistic regression.Severe (i.e., grade ≥ 3) hematological (38.6%), and gastrointestinal (12.9%) toxicities were common.A pre-existing nephrological condition was significantly associated with the risk of severe hematological toxicity with adjusted odds ratios (or) and 95% confidence intervals (cis) of 2.30 (1.32-4.01).Patients living in rural areas had a lower risk of severe hematological toxicity (or = 0.48; 95% ci, 0.30-0.77).Patients diagnosed with stage ii and stage iii-iv had a lower risk of severe gastrointestinal toxicity with ors and 95% cis of 0.26 (0.12-0.59) and 0.47 (0.20-1.10), respectively.Triple-negative/basal-like subtype was associated with a higher risk of severe hematological (or = 3.15; 95% ci, 1.56-6.34) and gastrointestinal toxicities (or = 3.60; 95% ci, 1.45-8.95) comparing to hormone receptor (hr)-positive her2-negative subtype.Further research investigating underlying mechanisms would facilitate the development and delivery of personalized treatment and care plans.

Journal: Current oncology (Toronto, Ont.) (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Research Support, N.I.H., Extramural
What complements complement in transplant-associated thrombotic microangiopathy?

Transplant-associated thrombotic microangiopathy remains a lethal complication of haematopoietic stem cell transplant and not all patients respond to terminal complement inhibitors.Qi et al.Show that hypoxia-inducible factor-1α (hif-1α) may be a previously unrecognized driver of this endothelial injury syndrome.Commentary on qi et al.Upregulation of hif-1α contributes to complement activation in transplantation-associated thrombotic microangiopathy.Br j haematol.2022 199:603-615.

Journal: British journal of haematology (2022)
Publication types: Journal Article
IMPACT OF DIABETIC NEUROPATHY ON QUALITY OF LIFE AND POSTURAL BALANCE IN BRAZILIAN OLDER ADULTS.

To analyze the impact of the peripheral diabetic neuropathy (pdn) on the postural and functional balance and quality of life of brazilian older adults.Methods a cross-sectional study.Sixty older men and women (60-79 years) were divided into three groups: control, dm without and with pdn.The following parameters were evaluated: anthropometry; quality of life; postural balance (bestest); functional balance in force plate (neuro com balance).Results pdn group presented significant differences compared with the other groups, with the worst performance in quality of life than dm2 without pdn in: sensory functioning (p= 0.030); past and future (p= 0.036); death and dying (p= 0.035).Postural balance deficit in the total score (p= 0.025) and biomedical constraints section (p= 0.043) of the bestest, compared with dm2 without pdn (p= 0.007).In the functional balance (neurocom), pdn group presented a worse performance in the time spent on the left side (p= 0.030) than the control group.During step up over test, the control group performed the task faster than the group with pdn (p= 0.004).Conclusion this study showed that neuropaths presented worse physical performance and postural balance deficits, sensorial limitations, affecting the daily tasks and, as a consequence, decreasing the quality of life in brazilian older adults.level of evidence ii, cross-sectional observational study.

Journal: Acta ortopedica brasileira (2020)
Publication types: Journal Article
Borderline Personality Pathology in Major Depressive Disorder, Bipolar I and II Disorder, and Its Relationship With Childhood Trauma.

Mood disorder and borderline personality pathology (bpp) are frequently comorbid and relate to childhood trauma.We investigated the relationship between childhood trauma and bpp features in mood disorder patients versus controls.Methods a total of 488 mood disorder patients, particularly major depressive disorder (mdd), bipolar i disorder (bd i), and bipolar ii disorder (bd ii), and 734 controls were included.We examined between-group bpp-related differences and correlated between bpp and childhood trauma using the childhood trauma questionnaire-short form (ctq) and the personality assessment inventory-borderline features scale.Results bd ii patients showed significantly higher bpp.Emotional abuse and neglect were prominently associated with bpp, while affective instability and negative relationships exhibited a stronger association with childhood trauma.We also found a positive relationship between childhood trauma and bpp in mdd, bd i, and bd ii patients.Conclusion the findings of the present study imply that bpp features are more likely to be found in patients with bd ii than bd i or mdd.Mood disorder patients with severe childhood trauma may have higher bpp features.Thus, further study of the relationship between childhood trauma and bpp features could improve the therapeutic approaches and help understand patients with mood disorders.

Journal: Psychiatry investigation (2022)
Publication types: Journal Article
Global patterns and predictors of C:N:P in marine ecosystems.

Oceanic nutrient cycles are coupled, yet carbon-nitrogen-phosphorus (c:n:p) stoichiometry in marine ecosystems is variable through space and time, with no clear consensus on the controls on variability.Here, we analyze hydrographic, plankton genomic diversity, and particulate organic matter data from 1970 stations sampled during a global ocean observation program (bio-go-ship) to investigate the biogeography of surface ocean particulate organic matter stoichiometry.We find latitudinal variability in c:n:p stoichiometry, with surface temperature and macronutrient availability as strong predictors of stoichiometry at high latitudes.Genomic observations indicated community nutrient stress and suggested that nutrient supply rate and nitrogen-versus-phosphorus stress are predictive of hemispheric and regional variations in stoichiometry.Our data-derived statistical model suggests that c:p and n:p ratios will increase at high latitudes in the future, however, changes at low latitudes are uncertain.Our findings suggest systematic regulation of elemental stoichiometry among ocean ecosystems, but that future changes remain highly uncertain.

Journal: Communications earth & environment (2022)
Publication types: Journal Article
The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis.

Over many decades, studies on histopathological features have not only presented high-level evidence of contribution for treatment directions and prognosis of oral squamous cell carcinoma (oscc) but also provided inconsistencies, making clinical application difficult.The 8th tnm staging system of oscc has acknowledged the importance of some histopathological features, by incorporating depth of invasion (doi) to t category and extranodal extension (ene) to n category.The aim of this systematic review with meta-analysis is to determine the most clinically relevant histopathological features for risk assessment and treatment planning of oscc and to elucidate gaps in the literature.Methods a systematic review was conducted using prisma guidelines, and the eligibility criteria were based on population, exposure, comparison, outcome, and study type (pecos).Pub med, cochrane, scopus, and web of science were searched for articles exploring the impact of histopathological features on oscc outcomes with cox multivariate analysis.Pooled data were subjected to an inverse variance method with random effects or fixed effect model, and the risk of bias was evaluated using quality in prognosis studies (quips).Quality of evidence was assessed with the grading of recommendations assessment, development, and evaluation (grade) criteria.Results the study included 172 articles published from 1999 to 2021.Meta-analyses confirmed the prognostic potential of doi, ene, perineural invasion, lymphovascular invasion, and involvement of the surgical margins and brought promising results for the association of bone invasion, tumor thickness, and pattern of invasion with increased risk for poor survival.Although with a small number of studies, the results also revealed a clinical significance of tumor budding and tumor-stroma ratio on predicted survival of patients with oscc.Most of the studies were considered with low or moderate risk of bias, and the certainty in evidence varied from very low to high.Conclusion our results confirm the potential prognostic usefulness of many histopathological features and highlight the promising results of others; however, further studies are advised to apply consistent designs, filling in the literature gaps to the pertinence of histopathological markers for oscc prognosis.Systematic review registration international prospective register of systematic reviews (prospero), identifier crd42020219630.

Journal: Frontiers in oncology (2021)
Publication types: Systematic Review;Journal Article