syedzayyan/paper_mill_benchmark huggingface dataset:
B-cell epitope peptide cancer vaccines: a new paradigm for combination immunotherapies with novel checkpoint peptide vaccine.

In light of the numerous us fda-approved humanized monoclonal antibodies (m abs) for cancer immunotherapy, it is surprising that the advancement of b-cell epitope vaccines designed to elicit a natural humoral polyclonal antibody response has not gained traction in the immune-oncology landscape.Passive immunotherapy with humanized m abs (trastuzumab [herceptin®]; pertuzumab [perjeta®]) has provided clinical benefit to breast cancer patients, albeit with significant shortcomings including toxicity problems and resistance, high costs, sophisticated therapeutic regimen and long half-life.The role of b-cell humoral immunity in cancer is under appreciated and underdeveloped.We have advanced the idea of active immunotherapy with chimeric b-cell epitope peptides incorporating a 'promiscuous' t-cell epitope that elicits a polyclonal antibody response, which provides safe, cost-effective therapeutic advantage over m abs.We have created a portfolio of validated b-cell peptide epitopes against multiple receptor tyrosine kinases (her-1, her-3, igf-1r and vegf).We have successfully translated two her-2 combination b-cell peptide vaccines in phase i and ii clinical trials.We have recently developed an effective novel pd-1 vaccine.In this article, i will review our approaches and strategies that focus on b-cell epitope cancer vaccines.

Journal: Future oncology (London, England) (2020)
Publication types: Journal Article;Review
Early coronary angiography in patients resuscitated from out of hospital cardiac arrest without ST-segment elevation: A systematic review and meta-analysis.

A meta-analysis of published studies was performed to determine the impact of performing early versus delayed or no coronary angiography in patients without st-segment elevation myocardial infarction following out of hospital cardiac arrest.Methods a structured search was conducted using medline, embase and ovid by two independent investigators using a variety of keywords.The primary outcome was short term (at discharge) and long term (at 6-14 months follow-up) mortality whereas the secondary end-point was good neurological outcome (defined as a cerebral performance category score of 1 or 2), at discharge and follow up.Random-effects model was utilized to pool the data, whilst publication bias was assessed using funnel plot.Results a total of 8 studies (7 observational studies and 1 randomized control trial) were identified and incorporated into the meta-analysis.The use of early angiography was associated with decreased short term (or=0.46, 95% ci=0.36-0.56, p<0.001) and long term (or=0.59, 95%ci=0.44-0.74, p<0.001) mortality.Early angiography was also shown to be associated with improved neurological outcomes on discharge (or=2.00, 95% ci=1.50-2.49, p<0.001) as well as on follow-up (or=1.48, 95% ci=1.06-1.90, p<0.001).Conclusion the results of our meta-analysis support the use of early coronary angiography in out of hospital cardiac-arrest patients presenting without st-segment elevation on the post-resuscitation electrocardiogram.However, given the low level of evidence of available studies, future guideline changes should be directed by the results of large-scale randomized clinical trials on the subject matter.

Journal: Resuscitation (2017)
Publication types: Journal Article;Meta-Analysis;Review;Systematic Review
The Effects of Photobiomodulation on Vocal Fold Wound Healing:In VivoandIn VitroStudies.

Photobiomodulation (pbm) is increasingly used in dermatology and dentistry due to its benefit of promoting wound healing and relieving pain; however, there is no corresponding research report on the application of pbm to vocal fold wound healing.objective:to assess the potential wound-healing effects of pbm on the vocal folds viain vivoandin vitroexperiments.materials and methods:inin vitrostudy, vocal fold fibroblasts (vffs) were irradiated under a diode laser with wavelength of 635 nm at energy density of 8 j/cm2.The cell counting kit-8 (cck-8) assay was used to study the viability of vffs, and the gene expressions of col1a2,col3a1,il-6,has2, and cox-2were investigated by real-time polymerase chain reaction (rt-pcr).Inin vivostudy, 15 rabbits were used.Lamina propria of the left vocal folds of 12 rabbits was unilaterally stripped, and 6 of them were treated with pbm.The remaining three rabbits served as normal controls.After 3 months, all animals were sacrificed to obtain histological results.We used laryngoscope to record images of the healing phase.results:irradiation with energy density of 8 j/cm2resulted in a 2.8% increase in cell proliferation (p< 0.05).However, the difference between the experimental and the control group became larger after 48 and 72 h of subsequent irradiation.Rt-pcr results showed that the expression of col1a2,col3a1, and has2was higher, and the expression of il-6and cox-2was lower.Histological examination showed that, compared with the injury group, hyaluronic acid (ha) increased significantly, collagen deposition decreased, and the configuration of collagen was more organized after pbm treatment.conclusions:pbm can inhibit inflammatory reaction and promote the secretion of ha to decrease the deposition of collagen and regenerate vocal fold tissue without scar.

Journal: Photobiomodulation, photomedicine, and laser surgery (2019)
Publication types: Journal Article
Recurrent Tissue-Aware Network for Deformable Registration of Infant Brain MR Images.

Deformable registration is fundamental to longitudinal and population-based image analyses.However, it is challenging to precisely align longitudinal infant brain mr images of the same subject, as well as cross-sectional infant brain mr images of different subjects, due to fast brain development during infancy.In this paper, we propose a recurrently usable deep neural network for the registration of infant brain mr images.There are three main highlights of our proposed method.(i) we use brain tissue segmentation maps for registration, instead of intensity images, to tackle the issue of rapid contrast changes of brain tissues during the first year of life.(ii) a single registration network is trained in a one-shot manner, and then recurrently applied in inference for multiple times, such that the complex deformation field can be recovered incrementally.(iii) we also propose both the adaptive smoothing layer and the tissue-aware anti-folding constraint into the registration network to ensure the physiological plausibility of estimated deformations without degrading the registration accuracy.Experimental results, in comparison to the state-of-the-art registration methods, indicate that our proposed method achieves the highest registration accuracy while still preserving the smoothness of the deformation field.The implementation of our proposed registration network is available online

Journal: IEEE transactions on medical imaging (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Impact of Mt. Olympus Honeys on Virulence Factors Implicated in Pathogenesis Exerted byPseudomonas aeruginosa.

The aim of this study was to examine the impact of twenty honey samples, harvested in mt.Olympus (greece), on the virulence factors implicated in p.Aeruginosapathogenesis.Six key virulence factors (protease and elastase activity, pyocyanin and pyoverdine concentration, biofilm formation, and swimming motility) were selected in order to assess the effect of the tested honeys compared with manuka honey.All tested honeys demonstrated a significant inhibition of protease and elastase activity compared with the control.Six and thirteen honeys exerted superior protease (no inhibition zone) and elastase (values lower than 55%) activity, respectively, compared with manuka honey.Seventeen tested honeys exhibited reduced pyoverdine production compared with the control; all tested honeys, except for one, showed an inhibitory effect on pyocyanin production compared with the control.Regarding swimming motility, nine tested honeys demonstrated significantly higher inhibition compared with manuka honey.Honey concentrations (6%v/vand 8%v/v) had the most profound impact, as they reduced biofilm formation to less than 20% compared with the control.Overall, our data demonstrate a significant inhibition of the virulence factors in the tested mt.Olympus honeys, highlighting the strong antimicrobial activity against p.Aeruginosa,an antibiotic-resistant pathogen of growing concern, which is implicated in severe nosocomial infections globally.

Journal: Antibiotics (Basel, Switzerland) (2023)
Publication types: Journal Article
The Health-Promoting and Sensory Properties of Tropical Fruit Sorbets with Inulin.

Inulin is a popular prebiotic that is often used in the production of ice cream, mainly to improve its consistency.It also reduces the hardness of ice cream, as well as improving the ice cream’s organoleptic characteristics.Inulin can also improve the texture of sorbets, which are gaining popularity as an alternative to milk-based ice cream.Sorbets can be an excellent source of natural vitamins and antioxidants.The aim of this study was to evaluate the effect of the addition of inulin on the sensory characteristics and health-promoting value of avocado, kiwi, honey melon, yellow melon and mango sorbets.Three types of sorbets were made—two with inulin (2% and 5% wt.) and the other without—using fresh fruit with the addition of water, sucrose and lemon juice.Both the type of fruit and the addition of inulin influenced the sorbet mixture viscosity, the content of polyphenols, vitamin c, acidity, ability to scavenge free radicals using dpph reagent, melting resistance, overrun and sensory evaluation of the tested sorbets (all p < 0.05).The addition of inulin had no impact on the color of the tested sorbets, only the type of fruit influenced this feature.In the sensory evaluation, the mango sorbets were rated the best and the avocado sorbets were rated the worst.Sorbets can be a good source of antioxidant compounds.The tested fruits sorbets had different levels of polyphenol content and the ability to scavenge free radicals.Kiwi sorbet had the highest antioxidant potential among the tested fruits.The obtained ability to catch free radicals and the content of polyphenols proved the beneficial effect of sorbets, particularly as a valuable source of antioxidants.The addition of inulin improved the meltability, which may indicate the effect of inulin on the consistency.Further research should focus on making sorbets only from natural ingredients and comparing their health-promoting quality with the ready-made sorbets that are available on the market, which are made from ready-made ice cream mixes.

Journal: Molecules (Basel, Switzerland) (2022)
Publication types: Journal Article
Tembusu virus infection in laying chickens: Evidence for a distinct genetic cluster with significant antigenic variation.

Tembusu virus (tmuv) associated disease is a growing cause of egg production decrease and encephalitis in domestic waterfowl, with expanding distribution.In previous studies, tmuv isolates were phylogenetically classified into two genetic lineages and different clusters with varied pathogenicity.However, little is known about the phenotypic and virulence characteristics of cluster 3 isolates within the duck tmuv lineage.In this study, the etiological agent causing egg drop in a laying chicken farm in southern china was investigated and a tmuv was isolated from pooled tissue samples.Genome sequencing and phylogenetic analysis grouped the isolate into tmuv cluster 3 with closest relation to the mosquito-origin tmuv yn12193.Cross-neutralization testing using convalescent sera revealed significant antigenic variation between the isolate and a representative strain of cluster 2.2.The experimental infection of spf hens confirmed the ability of the isolate to replicate in multiple tissues and led to ovary damage.Additionally, high seroconversion rates (95.83%-100%) were detected in the three flocks following retrospective investigation.Our study demonstrates the occurrence of cluster 3 tmuv infection in laying chickens and that the virus exhibits significant antigenic variation compared with cluster 2 tmuv.

Journal: Transboundary and emerging diseases (2022)
Publication types: Journal Article
Inhibition of Na+/H+Exchanger With EMD 87580 does not Confer Greater Cardioprotection Beyond Preconditioning on Ischemia-Reperfusion Injury in Normal Dogs.

Postischemic accumulation of intracellular na+promotes calcium overload and contributes to cellular necrosis.Cardioprotection afforded by pharmacologic blockade of the sodium-hydrogen exchanger subtype 1 (nhe1) is thought to be more remarkable than that obtained by ischemic conditioning (ic).The window of protection provided by ic pretreatment is maintained even when performed up to 48 hours before ischemia.In addition, the perception exists that combined nhe1 inhibition plus ic produces greater than additive protection against ischemic injury.The current study compared the efficacy of nhe1 blockade by n-[2-methyl-4,5-bis(methylsulfonyl)-benzoyl]-guanidine (emd 87580 5 mg/kg) combined with first- or second-window ic on ischemic tolerance in dogs subject to 90-minute acute ischemia and 180-minute reperfusion.Infarct size (tetrazolium staining), vascular responses, and myocardial perfusion (microspheres) were assessed.Emd 87580 given before ischemia or before reperfusion did not reduce infarct size (compared to vehicle-treated group).Significant protection against tissue necrosis was obtained by both first- and second-window ic, but additive cardioprotection (ie, greater than that afforded by ic) was not observed by treatment with emd 87580.Vascular reactivity in the infarct-related artery was not preserved after ischemia-reperfusion in any of the experimental groups.Likewise, either the pharmacologic or the nonpharmacologic interventions did not modify myocardial perfusion.These data demonstrate that emd 87580 did not protect against ischemia-reperfusion injury regardless of the time of drug administration.Combined emd 87580 and ic did not antagonize protection that was achieved by either first- or second-window ic alone; no additive protection beyond preconditioning was obtained.Further study is necessary to assess the value of nhe1 blockers as protective agents against myocardial injury.

Journal: Journal of cardiovascular pharmacology and therapeutics (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Gait and postural control patterns and rehabilitation in Down syndrome: a systematic review.

[purpose] to describe (1) the current knowledge on gait and postural control in individuals with down syndrome in terms of spatiotemporal, kinematics and kinetics, and (2) relevant rehabilitation strategies.[methods] randomized and non-randomized clinical trials published between january 1997 and october 2019 were selected by searching four scientific databases.We included studies on patients with down syndrome involving gait analysis or postural control.A custom data-extraction and appraisal form was developed to collect the key features of each article.The pedro scale was used to evaluate the methodological quality of the studies.[results] a total of 37 out of 146 cross-sectional and longitudinal studies were included in the review.The main abnormalities included: reduction of gait velocity and step length, poor static balance with increased anteroposterior and mediolateral oscillations and a larger step width.[conclusion] a number of compensatory patterns during movement was observed, with a direct influence on improvements in stability and postural control throughout daily life.Intensive gait training at an early age appears to produce long-term improvements in this population.Future research should focus on the interaction between the motor and cognitive function, and on the functional effects due to the exposure to an enriched environment.

Journal: Journal of physical therapy science (2020)
Publication types: Journal Article;Review
Barriers and facilitators to physical activity in second-generation British Indian women: A qualitative study.

To understand the barriers to and motivations for physical activity among second-generation british indian women.Subject approximately 50% of british south asians are uk-born, and this group is increasing as the second-generation also have children.Previous research into the barriers to and facilitators for physical activity has focused on migrant, first-generation populations.Qualitative research is needed to understand a) how we might further reduce the gap in physical activity levels between white british women and british indian women and b) the different approaches that may be required for different generations.Methods applying a socioecological model to take into account the wider social and physical contexts, we conducted semi-structured interviews with 28 indian women living in manchester, england.Interviews with first-generation british indian women were also included to provide a comparator.Interviews were audio-recorded, transcribed, thematically coded and analysed using a grounded theory approach.Results ways of socialising, concerns over appearance while being physically active, safety concerns and prioritising educational attainment in adolescence were all described as barriers to physical activity in second-generation british indian women.Facilitators for physical activity included acknowledging the importance of taking time out for oneself; religious beliefs and religious groups promoting activity; being prompted by family illness; positive messages in both the media and while at school, and having local facilities to use.Conclusions barriers to physical activity in second-generation indian women were very similar to those already reported for white british women.Public health measures aimed at women in the general population may also positively affect second-generation indian women.First-generation indian women, second-generation children and muslim women may respond better to culturally tailored interventions.

Journal: PloS one (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
"We All Have a Job to Do in This World, It's up to Us": Farmworker and Farmer Mental Health in a Rural US-Mexico Border Region.

Improving mental health outcomes for agricultural populations is dependent on understanding the unique farming related stressors in context of the local culture and community.This study was designed to assess the prevalence of stressors and mental health risks among farmers and farmworkers in a rural, medically underserved us-mexico border region.Of 135 study respondents, 55.6% (n = 18) farmers had clinical depression symptomatology based on the center for epidemiologic studies depression screening scale (ces-d) and 40.2% (n = 117) farmworkers had stress levels that pose significant mental health risks based on the migrant farmworker stress inventory.Farmworker females were 2.3 times more likely to have a score of clinical concern.Results provide an understanding of the distinct sources of stress for both farmers and farmworkers and the mental health challenges across the industry.With an understanding that suicide is the third leading cause of injury death in imperial county and depression associated with an increased risk of suicidality, the agricultural workforce in imperial county is particularly vulnerable.Local farm organizations, employers, and community organizations can help increase mental health access, acceptability, and availability to achieve greater safety and health in the region's largest workforce.

Journal: Journal of agromedicine (2023)
Publication types: Journal Article;Research Support, U.S. Gov't, P.H.S.
Childlessness and upward intergenerational support: cross-national evidence from 11 European countries.

Childless individuals are often depicted as "selfish" as they opt out of raising children in favour of investing resources in themselves.Yet no research has investigated whether this claim holds in domains of social life such as intergenerational family support.Using data from the generations and gender survey (ggs) for 11 european countries, this article examines differences between childless and non-childless individuals in the provision of financial, practical, and emotional transfers to their elderly parents.Results support the idea that the childless are more prone to providing upward support than individuals with children.Specifically, estimates from multivariate logistic regression and propensity score specifications suggest that,ceteris paribus, childless adults are about 20 to 40 per cent more likely to provide support to their parents, with the association driven by transfers to elderly mothers.These findings enrich the literature on childlessness and ageing, and support the view that researchers and policy makers should take into more consideration not only what childless people receive or need in old age, but also what they provide as middle-aged adults.

Journal: Ageing and society (2019)
Publication types: Journal Article
Effects of Postdischarge High-Protein Oral Nutritional Supplements and Resistance Training in Malnourished Surgical Patients: A Pilot Randomized Controlled Trial.

The presence of malnutrition is increasingly becoming a postdischarge problem in surgical patients.We aimed to investigate whether oral nutritional supplements combined with resistance training could minimize skeletal muscle atrophy in surgical patients after discharge.This randomized controlled study was conducted at the department of surgery, national hospital of faroe islands from 2018 to 2020.A total of 45 patients aged 37−74 years participated and were allocated to one of three groups: diet (di; n = 13), exercise and diet (ex + di; n = 16), or control (con; n = 16).The intervention period lasted 8 weeks.The intervention groups received individual dietary counselling and a protein-rich oral nutritional supplement twice a day containing 22 g of protein/day.Patients in the ex + di group were assigned to resistance training sessions.Patients in the con group received standard care.The primary outcome was change in lean body mass (lbm).Secondary outcomes were change in body weight, handgrip strength, quality of life, surgery-related side effects, energy and protein intake, length of stay and one-year mortality.To estimate within-group changes, linear mixed models including group−time interactions as fixed effects and patients as random effects were fitted.Within-group change in lbm was 233, 813 and 78 g in the di, ex + di and con groups, respectively, with no significant between-group difference (p > 0.05).Pain score declined more (p = 0.04) in the ex + di group compared with the con group.Body weight, handgrip strength, quality of life and surgery-related side effects did not differ between groups.At the end of study, mean cumulative weight change in the di and ex + di groups was 0.4% and 1.6%, respectively, whereas the con group experienced a weight loss of −0.6%.No significant difference in primary outcome between groups was noted.However, our results indicate some benefits from exercise and nutrition for malnourished surgical patients.

Journal: Nutrients (2022)
Publication types: Journal Article;Randomized Controlled Trial
Photo Cross-linkable Biopolymers for Cornea Tissue Healing.

Light can act as an effective and strong agent for the cross-linking of biomaterials and tissues and is recognized as a safe substitute for chemical cross-linkers to modify mechanical and physical properties and promote biocompatibility.This review focuses on the research about crosslinked biomaterials with different radiation sources such as laser or ultraviolet (uv) that can be applied as scaffolds, controlled release systems,and tissue adhesives for cornea healing and tissue regeneration.

Journal: Current stem cell research & therapy (2022)
Publication types: Journal Article;Review