syedzayyan/paper_mill_benchmark huggingface dataset:
Measures of Lower Body Strength Associated With Injuries in Australian Special Forces Selection Candidates.

The diverse and grueling nature of activities undertaken during special forces selection makes it difficult to develop physical training to improve performance and reduce injury risk.It is generally accepted that increased strength is protective against injury, but it is unclear if this is evident in a special forces selection environment.This study investigated the effect of the rigors of a special forces selection course has on performance of the isometric mid-thigh pull, countermovement jump, squat jump, drop landing, elastic utilization ratio (eur), and injury occurrence.Throughout the course, 26% of participants sustained a preventable lower limb injury, with 65% of these occurring at the knee.The uninjured had higher values of absolute strength as measured by isometric mid-thigh pull peak absolute force (3399 [371] n, 3146 [307] n; p = .022) and lower eur (0.94 [0.08], 1.01 [0.09]; p = .025) compared to the injured.Preventable knee injury was significantly correlated with isometric mid-thigh pull (r = -.245, p = .031) and eur (r = .227, p = .044).The selection course altered eur for uninjured individuals only (p = .004).Findings indicate that individuals with higher strength levels may be at a lower risk of injury than their weaker counterparts.

Journal: Journal of applied biomechanics (2022)
Publication types: Journal Article
BCL6 inhibitor FX1 attenuates inflammatory responses in murine sepsis through strengthening BCL6 binding affinity to downstream target gene promoters.

Sepsis occurs when an infection triggers deranged inflammatory responses.There exists no efficacious treatment for this condition.The transcriptional repressor b-cell lymphoma 6 (bcl6) is known to act as an inhibitor of macrophage-mediated inflammatory responses.Fx1, a novel specific bcl6 btb inhibitor, is able to attenuate activity of b cell-like diffuse large b cell lymphoma (abc-dlbcl).Nevertheless, the effect of fx1 in inflammatory responses and sepsis remains unknown.Objectives here, we explored the effect and potential mechanisms of fx1 on the regulation of lps-induced inflammatory responses in murine sepsis.Method mice models of lps-induced sepsis were monitored for survival rate following fx1 administration.Elisa was used to assess how fx1 administration affected pro-inflammatory cytokines present in macrophages exposed to lps and in the serum of mice sepsis models.Flow cytometric analysis, western blot and q rt-pcr were performed to evaluate differences in macrophages immune responses after fx1 pre-treatment.Finally, the affinity of bcl6 binding to downstream target genes was checked by ch ip.Results the survival rate of mice models of lps-induced sepsis was improved in following fx1 administration.Fx1 decreased the production of inflammatory cytokines, attenuated macrophage infiltration activities and reduced monocytes chemotaxis activities, all of which suggest that fx1 exert anti-inflammatory effects.Mechanistically, fx1 may enhance the affinity of bcl6 binding to downstream target pro-inflammatory genes.Conclusions these findings illustrated the anti-inflammatory properties and potential mechanisms of fx1 in sepsis caused by lps.Fx1 could potentially become a new immunosuppressive and anti-inflammatory drug candidate in sepsis therapy.

Journal: International immunopharmacology (2019)
Publication types: Journal Article
mRNA Vaccines as an Efficient Approach for the Rapid and Robust Induction of Host Immunity Against SARS-CoV-2.

Among the currently used covid-19 vaccines, the m rna-based vaccines drew the interest of the scientists because of its potent and versatile nature in mitigating the disease efficiently through increased translation as well as the robust modulation of the innate and adaptive immune responses within the host.The naked or lipid encapsulated m rnas are usually optimized in order to formulate the vaccine.One of the interesting advantage of using m rna vaccines is that such platform can even be used to mitigate other infectious diseases like influenza, zika, and rabies.However, the leading covid-19 m rna vaccines, i.e., m rna-1273 and bnt162b2, have already been noticed to possess around 95% efficacy in provoking both the humoral and cell mediated immunity against the severe acute respiratory syndrome coronavirus 2 (sars-co v-2) infection, causing the ongoing covid-19 pandemic.

Journal: SN comprehensive clinical medicine (2022)
Publication types: Journal Article;Review
Design and Synthesis of Biotinylated Bivalent Carboline Derivatives as Potent Antitumor Agents.

Compound6, a novel β-carboline comprising two 1-methyl-9h-β-carboline-3-carboxylic acids and a biotin moiety conjugated together using tris(2-aminoethyl)amine, was synthesized and tested for its cytotoxicity toward mcf-7 and hep g2 cell lines and antitumor potency in an s180 tumor-bearing mouse model.Compound6was delivered via biotin receptor-mediated endocytosis and exerted its therapeutic effects by intercalation binding with dna.in vivoantitumor evaluations of6revealed that it is efficacious and exhibits low systemic toxicity.

Journal: The Journal of organic chemistry (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Growth-Defense Trade-Offs Induced by Long-term Overgrazing Could Act as a Stress Memory.

Long-term overgrazing (og) is one of the key drivers of global grassland degradation with severe loss of productivity and ecosystem functions, which may result in stress memory such as smaller stature of grassland plants.However, how the og-induced stress memory could be regulated by phytohormones is unknown.In this study, we investigated the changes of four phytohormones of cloned offspring of leymus chinensisthat were developed from no-grazing (ng) plants and og plants with a grazing history of 30 years.The concentrations of auxin (iaa) and gibberellic acid (ga) in og plant leaves were 45% and 20% lower than control, respectively.Meanwhile, the level of abscisic acid (aba) in og leaves nearly doubled compared with that in ng leaves.The situation was quite similar in roots.Unexpectedly, no significant changes in the jasmonic acid (ja) level were observed between og and ng plants.The changes in gene expression patterns between og and ng plants were also investigated by transcriptomic analysis.In total, 302 differentially expressed genes (degs) were identified between og and ng plants, which were mainly classified into the functions of synthesis, receptor, and signal transduction processes of phytohormones.The expression of 24 key genes related to the biosynthesis and signal transduction of iaa and ga was downregulated in og plants.Among them,oasa1and ao1(regulating the biosynthesis of iaa and aba, respectively) were reduced significantly by 88 and 92%, respectively.In addition, the content of secondary metabolites related to plant defense such as flavonoids and phenols was also increased in leaves.Taken together, the decrease of positive plant growth-related hormones (iaa and ga) together with the increase of plant stress-related hormones or factors (aba, flavonoids, and phenols) induced the growth-defense trade-offs for l.Chinensisadaptation to long-term og stress.The findings reported in this study shed new light on the mechanism of plant-animal interaction in the grassland ecosystem and provide a deeper insight into optimizing grazing management and sustainable utilization of grassland.

Journal: Frontiers in plant science (2022)
Publication types: Journal Article
Evaluating the content of a patient-reported outcome measure for people with multimorbidity: a Delphi consensus.

Evidence supporting multimorbidity-adapted interventions is scarce, mostly due to a lack of adapted outcome measures.Measurement constructs for a novel patient-reported outcome measure (prom) were defined in previous studies using a literature review, a qualitative description from stakeholders, and an item pool identification process.The aim of this study was to attain consensus on the content of this novel prom.Methods a three-round electronic modified delphi technique was conducted using an academic and clinical expert panel.Using a likert scale, the panel rated the relevance, improvability, and self-ratability of each construct and item of the preliminary version of the prom.The main outcome was consensus attainment, defined as strong (≥ 70%), moderate (50-69%) or low agreement (< 50%).Constructs and items with strong consensus were kept, moderate were sent to the next round and low agreement were rejected.Results from the 61 experts contacted, 39 participated in the first round of the delphi, with a 12.8% attrition at the second round (n = 34) and 38.2% at the third round (n = 21).The panel included mostly female academic experts from nursing and medicine backgrounds.The preliminary prom included 19 constructs and 70 items; from these, 16 constructs and 50 items attained consensus.The consensus attainment process excluded three constructs and their items: awareness, weight control and social integration.Conclusion consensus was reached for a patient-reported outcome measure adapted for people with multimorbidity including 50 relevant, improvable and self-ratable items categorized under 16 constructs.As more interventions tailored to multimorbidity are implemented, there is an increasing need for a valid measure of the effectiveness of these interventions.

Journal: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation (2021)
Publication types: Journal Article
Putative Meiotic Toolkit in the Dinoflagellate Prorocentrum cordatum: Additional Evidence for Sexual Process from Transcriptome.

Prorocentrum cordatum (ostenfeld) dodge-is a planktonic armored dinoflagellate that is a bloom-forming, potentially toxic cosmopolitan species.The transition from vegetative reproduction to the sexual process has been recently shown for this organism.Here, we present the results of transcriptomic data analysis that uncovered one syngamy-associated and 16 meiosis-associated proteins in p.Cordatum.We also detected an amino acid sequence homologous to bacterial mut s2 protein.The mut s2 presence and origin in dinoflagellates are discussed for the first time.

Journal: The Journal of eukaryotic microbiology (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Harnessing Colossal Magnetic Anisotropy in Sandwiched 3d2-Metallocenes.

Single-molecule magnets are gaining attention in recent years with the growing focus on achieving higher barriers of magnetization reversal.Metallocenes, owing to their unique sandwiched structure, assure themselves as plausible molecular systems for the development of novel single-molecule magnets (smms).Here in this work, we have explicitly investigated metallocenes of first-row transition elements, along with their one-electron-oxidized (cationic) and -reduced (anionic) analogues, for their magnetic anisotropies by adopting multireferenceab initiocalculations.Herein, we report a high magnetic anisotropy for 3d2systems among all 3d-metallocenes.

Journal: The journal of physical chemistry. A (2022)
Publication types: Journal Article
The Effects of Supervised Exercise Training on Weight Control and Other Metabolic Outcomes in Patients With Type 2 Diabetes: A Meta-Analysis.

Few studies have investigated the dose-response relationship between exercise and weight control.This study aimed to assess the effects of different types of supervised exercise training on weight control and other metabolic outcomes in patients with type 2 diabetes mellitus and explore the dose-response relationship between exercise volume/duration and these outcomes.Pub med/medline, embase, and cochrane databases were searched for studies between january 1980 and june 2019.Randomized control trials in type 2 diabetes mellitus patients with supervised exercise training versus control treatment were included.The primary outcome was changes in body weight (kg).The secondary outcomes included changes in waist circumference (cm) and total body fat percentage (%).Forty-two randomized control trials, including 3,625 patients with type 2 diabetes mellitus were included.Overall, exercise treatment was associated with significant reduction in body weight (weighted mean differences, -1.10 kg; 95% ci [-1.58, -0.62], p < .01), waist circumference (weighted mean differences, -2.51 cm; 95% ci [-3.25, -1.77], p < .01), and total body fat (weighted mean differences, -1.16%; 95% ci [-1.58%, -0.75%], p < .01).The percentage of total body fat was reduced by all types of exercise, with a significant difference between aerobic exercise and resistance exercise (p = .02) and a significant difference between combined exercise and resistance exercise (p < .01).A higher volume of aerobic exercise and a higher volume of resistance exercise were superior in reducing body weight.In conclusion, supervised exercise training improved metabolic outcomes in general, while different types and volume of exercises have their own merits.

Journal: International journal of sport nutrition and exercise metabolism (2022)
Publication types: Journal Article;Meta-Analysis
Elevation of activated neutrophils in chronic rhinosinusitis with nasal polyps.

Chronic rhinosinusitis (crs) with nasal polyps (crsw np) is well characterized by type 2 (t2) inflammation characterized by eosinophilia in western countries.However, the presence and roles of neutrophils in t2 crsw np are poorly understood.Objective we sought to clarify accumulation and inflammatory roles of neutrophils in crsw np in a western population.Methods sinonasal tissues and nasal lavage fluids were obtained from control patients and patients with crs, and neutrophil markers were determined by elisa.The presence of neutrophils in tissue was determined by flow cytometry.The gene expression profiles in neutrophils were determined by rna sequencing.Results a neutrophil marker elastase was selectively elevated in nasal polyp (np) tissue, whereas eosinophilic cationic protein (an eosinophil marker) was elevated in both uncinate and np tissues of crsw np patients.Nasal lavage fluid myeloperoxidase (another neutrophil marker) was also significantly elevated in crsw np compared to control patients.Neutrophil markers were more greatly elevated in crsw np patients with recurrent disease.Flow cytometric analysis confirmed that neutrophil numbers were significantly elevated in nps compared to control tissues.Rna sequencing analysis found that 344 genes were >3-fold and significantly elevated in np neutrophils compared to peripheral blood neutrophils.Gene ontology analysis suggested that the elevated genes in np neutrophils were significantly associated with activation.Results suggest that neutrophils are accumulated in t2 np tissues and that accumulated neutrophils are highly activated and contribute to inflammation in nps.Conclusions neutrophils may play a heretofore unrecognized meaningful role in the pathogenesis of crsw np in western countries and may be a potentially important therapeutic target in t2 crsw np.

Journal: The Journal of allergy and clinical immunology (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Multiple anti-non-alcoholic steatohepatitis (NASH) efficacies of isopropylidenyl anemosapogenin via farnesoid X receptor activation and TFEB-mediated autophagy.

Non-alcoholic steatohepatitis (nash) can develop into cirrhosis, liver failure, or hepatocellular carcinoma without effective treatment.However, there are currently no drugs for nash treatment, and the development of new therapeutics has remained a major challenge in nash research.Advances in traditional chinese medicine to treat liver disease inspired us to search for new nash candidates from chi-shao, a widely used traditional chinese medicine.Purpose in this research, we aimed to clarify the anti-nash effect and the underlying mechanism of isopropylidenyl anemosapogenin (ia, 1), which was a new lead compound isolated from chi-shao.Study design and methods isopropylidenyl anemosapogenin (ia, 1) was first discovered by collagen type i α 1 promoter luciferase bioassay-guided isolation and then characterized by single crystal x-ray diffraction analysis and enriched by semi-synthesis.Using various molecular biology techniques, the multiple anti-nash efficacies and mechanisms of ia were clarified based on in vitro lx-2 and huh7 cell models, along with the in vivo choline-deficient, l-amino acid-defined, high-fat diet (cdahfd)-induced mouse model and bile duct ligation (bdl)-induced rat model.The uplc-ms/ms method was used to assess the plasma concentration of ia.Results a new lead compound ia was isolated from the traditional chinese medicine chi-shao, which showed significant anti-liver fibrosis activity in tgf-β1-treated lx-2 cells and anti-liver steatosis activity in oleic acid-treated huh7 cells.Furthermore, ia could significantly ameliorate in vivo cdahfd-induced liver injury by activating the farnesoid x receptor pathway, including its targets nr0b2, abcb11, and slc10a2.Simultaneously, ia activated the autophagy pathway by activating the tfeb factor, thereby promoting lipid degradation.Its liver-protective and anti-fibrosis activities were verified by the bdl-induced rat model.Finally, with an oral administration of 100 mg/kg, ia achieved the maximum plasma concentration of 1.23 ± 0.18 μg/ml at 2.67 ± 0.58 h.Conclusion ia, an unreported lupine-type triterpenoid isolated from chi-shao, can significantly alleviate liver injury and fibrosis via farnesoid x receptor activation and tfeb-mediated autophagy, which indicates that ia could serve as a novel therapeutic candidate against nash.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology (2022)
Publication types: Journal Article
Effect of meteorological factors on the activity of influenza in Chongqing, China, 2012-2019.

The effects of multiple meteorological factors on influenza activity remain unclear in chongqing, the largest municipality in china.We aimed to fix this gap in this study.Methods weekly meteorological data and influenza surveillance data in chongqing were collected from 2012 to 2019.Distributed lag nonlinear models (dlnms) were conducted to estimate the effects of multiple meteorological factors on influenza activity.Results inverted j-shaped nonlinear associations between mean temperature, absolute humidity, wind speed, sunshine and influenza activity were found.The relative risks (rrs) of influenza activity increased as weekly average mean temperature fell below 18.18°c, average absolute humidity fell below 12.66 g/m3, average wind speed fell below 1.55 m/s and average sunshine fell below 2.36 hours.Taking the median values as the references, lower temperature, lower absolute humidity and windless could significantly increase the risks of influenza activity and last for 4 weeks.A j-shaped nonlinear association was observed between relative humidity and influenza activity; the risk of influenza activity increased with rising relative humidity with 78.26% as the break point.Taking the median value as the reference, high relative humidity could increase the risk of influenza activity and last for 3 weeks.In addition, we found the relationship between aggregate rainfall and influenza activity could be described with a u-shaped curve.Rainfall effect has significantly higher rr than rainless effect.Conclusions our study shows that multiple meteorological factors have strong associations with influenza activity in chongqing, providing evidence for developing a meteorology-based early warning system for influenza to facilitate timely response to upsurge of influenza activity.

Journal: PloS one (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Recent Advances in Deep Eutectic Solvents as Shale Swelling Inhibitors: A Comprehensive Review.

Inhibitors have evolved from their primary function of controlling swelling during hydraulic fracturing processes in shale reservoirs.This study provides a comprehensive review of recent deep eutectic solvent (des) advancements as inhibitors in swelling inhibition techniques.The swelling inhibitory potentials and mechanisms of dess have been studied analytically and compared to existing conventional inhibitors.The functional effects of concentration, temperature, and types of des are explored.Data on the effect of des on rheology, swelling, zeta potential, shale cutting recovery, surface tension, particle size distribution, xrd, and ftir analyses are presented.Along with preparation procedures, environmental concerns and applications of dess in several fields are discussed.This study suggests that dess are preferable swelling inhibitors due to their inhibitory performance, cost-effectiveness, and environmental friendliness.Moreover, this review includes guidelines and recommendations for selecting and designing des to inhibit swelling more effectively.

Journal: ACS omega (2022)
Publication types: Journal Article;Review
Assessing the potential of a Virtual Patient Advocate to provide preconception care and health advice to women living in Australia.

A preconception virtual patient advocate (vpa) called "gabby" supported african-american women to decrease their preconception health risks and may be a scalable resource to increase women's access to preconception care.Aims were to assess the acceptability of a preconception vpa in women living in australia and document the changes required to adapt gabby to suit an australian context.Taking a descriptive qualitative approach, nonpregnant female participants (n = 31), aged 18-45 years, living in metropolitan and regional victoria, australia interacted with gabby.Focus groups (n = 7) that gathered participants' perspectives of their experience with gabby ran in july-august 2019 before being transcribed verbatim and thematically analyzed.Six interrelated themes and 12 subthemes were identified.Participants found vpas to be an acceptable provider of health information with potential to increase women's access preconception health advice.Gabby was considered to be trustworthy and was able to develop rapport with participants in a relatively short time.Context-specific, relevant, tailored and trustworthy information and advice were considered more important that gabby's physical appearance.Participants had strong opinions about potential technological advancements (e.g., reminders and rewards) and addressing navigation issues to increase gabby's acceptability.Participants envisaged that they would use gabby for readily available and evidence-based information before seeking advice from a health professional if required.Overall, the concept vpas to provide preconception advice and gabby were acceptable to participants.Future development of vpas, gabby, and other online technology-based resources should consider women's high expectations of the online health information they choose to interact with.

Journal: Journal of developmental origins of health and disease (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't