syedzayyan/paper_mill_benchmark huggingface dataset:
Clinical Rehabilitation Nursing of Patients with Chronic Obstructive Pulmonary Disease Based on Intelligent Medicine

Chronic obstructive pulmonary disease (copd) is a respiratory disease that can be treated and prevented.The purpose of this paper is to conduct a meta-analysis of clinical rehabilitation nursing of copd patients based on intelligent medical care by constructing a suitable model so as to make the research on clinical nursing of copd patients more effective.This paper first introduced the intelligent medical system, analyzed the clinical rehabilitation nursing of copd patients, established the scnet model suitable for this paper, and then used statistical algorithms to carry out the meta dynamic analysis of the clinical rehabilitation nursing for copd patients.Through the analysis of the current situation of medical equipment and the comparison of models and statistical analysis, the experimental results showed that the pulmonary function indexes of the pulmonary rehabilitation treatment group and the conventional treatment group were improved after treatment compared with before treatment.Although on specificity metrics scnet did not perform the best, it was about 1% lower than the best baseline model.However, the comprehensive performance of the scnet model on acc, sen, f1-score, and ap indicators showed that the model scnet proposed in this paper had certain advantages, which was helpful for the clinical rehabilitation care of patients with copd and could better assist doctors in treatment.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Long-Term Mechanism and Fitness Impact of Rural Sports Precision Poverty Alleviation Based on Improved Decision Tree

In the process of the development of sports resources, the first step is to strengthen mechanism construction, including the government and the market “- poor areas” tripartite coordination mechanism, the development of sports resource development policy supervision mechanism, sports resource development precision poverty alleviation mechanism, legal protection mechanism, and accountability mechanism.The establishment of the fitness model recommendation model is realized.The fitness pattern recommendation model itself is a multibranch decision tree model.Therefore, as long as it is a variety of fitness methods, according to different classification, in the fitness database to add the corresponding classification, this is helpful to build a multibranch decision tree model.

Journal: Wireless Communications and Mobile Computing (2022)
Publication types: Research Article;
Experimental Study on the Central Mechanism of Penehyclidine Hydrochloride against Relapse Behavior in Morphine-Dependent Rats

This article is mainly to study the central mechanism of penehyclidine hydrochloride against relapse behavior in morphine-dependent rats.Methods.The rats were randomly divided into the blank control group (k), phc low-dose group (lp according to a body weight of 0.22 mg/kg), middle-dose group (mp according to a body weight of 0.55 mg/kg), high-dose group (hp according to a body weight of 1.38 mg/kg), and administration group, with 40 rats in each group.Each group was randomly divided into 5 subgroups ( n = 10 ): 4 h after administration, 7 h after administration, 13 h after administration, 25 h after administration (k48, lp48, mp48, and hp48), and 37 h after administration, and then, morris water maze experiment and immunohistochemical detection of the rat brain hippocampus were carried out.Results.4 and 7 hours after administration, compared with group 1, the tch e activity increased and ach level decreased in groups 2, 3, and 4 and the difference was significant ( p &lt; 0.05 ), so the principle of penehyclidine hydrochloride against morphine-dependent rats is that penehyclidine hydrochloride causes cognitive impairment in the brain of mice, thereby achieving antimorphine effects.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Exploration on Molecular Mechanism of Reversal Effect of Compound Danshen Tablets on Hepatic Fibrosis Based on Network Pharmacology

To research the molecular mechanism of compound danshen tablets in the treatment of hepatic fibrosis through network pharmacology.Methods.Traditional chinese medicine systems pharmacology (tcmsp) and online mendelian inheritance in man (omim) databases were searched for compound danshen tablets’ active ingredients o and hepatic fibrosis-related genes.The network enrichment of the targets of “herb-compound-target” was visualized and analyzed using cytoscape software.Then, the screened target genes were used to construct a protein-protein interaction network.The david enrichment database (the database for annotation, visualization, and integrated discovery) was adopted for go (gene ontology) enrichment and kegg (kyoto encyclopedia of genes and genomes) pathway enrichment of vital nodes.Results.The results yielded 234 targets of compound danshen tablets; ten important targets (tnf, il-10, tgf-β1, egf, cxcl16, ccl21, serpinb5, serpina1, sod2, and ppig) for reversing hepatic fibrosis; and four core targets (tnf, il-10, tgf-1, and egf).In addition, kegg enrichment analysis showed that compound danshen tablets mainly involved fox o and mapk signaling pathways, as the key signaling pathways in the treatment of hepatic fibrosis.Conclusion.Tnf, il-10, tgf-1, and egf and foxo and mapk signaling pathways play a key role in the pathogenesis of hepatic fibrosis.Based on the results of this study, the mechanism of action of compound danshen tablets in the treatment of hepatic fibrosis may be associated with the regulation of fox o and mapk signaling pathways and inhibition of tnf, il-10, tgf-1, and egf.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Role of Phosphatidylinositol 3-Kinase and Its Catalytic Unit PIK3CA in Cervical Cancer: A Mini-Review

In complicated disorders like cancer, signaling pathways form a tangled network.Targeting one gene may result in an unfavorable reaction from another off-target gene.Such entwined complexities may result in treatment resistance or failure in cancer patients.The pi3k/akt/m tor (phosphoinositol 3-kinase/protein kinase b/mammalian target of rapamycin) pathway is dysregulated in cervical cancer and is used as a biomarker for therapy.Pi3k is a kinase that consists of a regulatory and catalytic domain and has phosphorylation capability.Class i components like the catalytic part (pik3ca and pik3cd) and regulatory part (like pik3r1, pik3r2, pik3r3, and pik3r5) are associated with oncogenesis and growth factors in cervical cancer.This review is aimed at discussing the involvement of the pi3k component of the pi3k/akt/m tor network in cervical cancer.Specifically, class i catalytic subunit pik3ca has been identified as a pharmacological target, making it therapeutically significant.Apart from discussing the function of pi3k and pik3ca in cervical cancer, we also discuss their inhibitors, which may be beneficial in treating cervical cancer.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Review Article;
Factors Affecting Transfusion during Percutaneous Nephrolithotomy: A Retrospective Study of 665 Cases

This study was designed to evaluate the aspects that affect transfusion following percutaneous nephrolithotomy (pcnl).Patients and methods.From 2016 to 2019, 665 patients underwent pcnl for the removal of renal calculi at our center (department of urology, shanghai xu-hui central hospital).Complications, including hemorrhages, have been reported.Twenty-three patients (3.5%) have received a blood transfusion, and 12 (1.9%) patients were treated with hyper-selective embolization.We focused on the influencing factors related to postoperative blood transfusion.The factors analyzed were age, sex, hypertension, diabetes, serum creatinine level, preoperative hemoglobin, and the use of anticoagulants or antiplatelet medications; renal and stone factors (i.e., previous surgery, abnormal anatomy, stone side, stone burden, and stone type); and surgical features (i.e., access number, the calyx of puncture, and stone-free rate).These data were analyzed for the presence of bleeding.Results.Among individual factors, preoperative hemoglobin level ( p &lt; 0.001 ) and urinary infections ( p &lt; 0.001 ) were significantly correlated with blood transfusion.Among renal and stone factors, only a history of open surgery was significantly correlated with blood transfusion ( p &lt; 0.05 ).Stone type or stone burden did not correlate with transfusion.Furthermore, no statistically significant correlation was found between surgical features and bleeding, and a lower stone-free rate was reported for the transfusion group.Conclusion.The obtained results demonstrated that pcnl is a safer surgical procedure in a high-volume center; however, anemic conditions, infections, and history of open surgery will significantly increase the transfusion rate following pcnl.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Research on Automobile Assembly Line Optimization Based on Industrial Engineering Technology and Machine Learning Algorithm

Ing at the lack of search depth of traditional genetic algorithm in automobile assembly line balance optimization, an improved genetic algorithm based on bagging integrated clustering is proposed for balance optimization.Through the integrated learning of several k ‐means algorithm based learners through bagging, a population clustering analysis method based on bagging integrated clustering algorithm is established, and then, a dual objective automobile assembly line balance optimization model is established.The population clustering analysis method is used to improve the intersection link of genetic algorithm to improve the search depth.The effectiveness and search performance of the improved genetic algorithm in solving the double objective assembly line balance problem are verified in an example.

Journal: Wireless Communications and Mobile Computing (2021)
Publication types: Research Article;
Journalists’ Response and Reporting of Public Emergencies in the Era of Artificial Intelligence

In order to improve the response ability of journalists to public emergencies, this study uses the computer simulation research method, based on shannon’s information theory and the basic theory of journalism and communication, constructs the general model of public emergencies based on the statistical results of big data, and constructs the irrational natural person game model of four types of news communication participants.In the simulation analysis, it is found that in the face of public emergencies, journalists, on the one hand, firmly implement the publicity caliber, strengthen the amount of creation, and improve the forwarding amount and approval amount of manuscripts under the artificial intelligence news system.On the other hand, they should achieve effective interaction with nonofficial news media such as we media, and the subjective news department should provide effective guidance and guidance to the media.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
The Relationship between Gestational Newborn Weight Loss and Hospitalization in the First Week after Birth

To investigate the association of weight loss daily of term infants with hospitalization in the first week after birth.Methods.This prospective cohort study was conducted among 1865 infants from may 2020 to june 2021, born in the department of obstetrics, kunshan’s first people’s hospital affiliated to jiangsu university and huai’an maternal and child health care center.The infants’ weight was collected daily in the hospital, and the weight loss was calculated daily.According to the weight loss daily, the infants were divided into 3 groups.Group a: the weight loss per day was less than 2% of birth weight, and the total weight loss was less than 10%.Group b: the weight loss per day was between 2 and 4% of the birth weight, and the total weight loss was less than 10%.Group c: the weight loss per day was more than 4% of the birth weight, or the total weight was more than 10%.The infants in group c were monitored carefully in the hospital or outpatient department (opd) daily.The primary outcome was the incidence of hospitalization.Results.Of the 1865 term infants enrolled, 1052 were completed on the 7th day (356 in group a, 513 in group b, and 183 in group c).There was no significant difference among the three groups of subjects in terms of infant data, including birth weight, gender, apgar scores, and gestational age.The number of c-sections and primiparas was substantially higher in groups c and b than in group a.The incidence of hospitalization in group c was significantly higher than that in group a and group b (30.6%, 12.1%, and 12.5%, respectively).The incidence of exclusive breastfeeding in group c was significantly lower than that in group a and group b (28.4%, 41%, and 38.4%, respectively).There was no significant difference between group a and group b in the incidence of hospitalization and exclusive breastfeeding.Most of the hospitalization was because of hyperbilirubinemia, and in group c, there were 2 babies because of dehydration fever and 3 because of hypoglycemia.Conclusions.The neonates whose weight loss daily after birth was more than 4% of the total weight loss of more than 10% had higher hospitalization rates.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Establishment of a Risk Prediction Model for Pulmonary Infection in Patients with Advanced Cancer

Based on clinical data, the risk prediction model of pulmonary infection in patients with advanced cancer was established to predict the risk of pulmonary infection in patients with advanced cancer, and intervention measures were given in advance.Methods.The clinical data of 2755 patients were divided into infection group and control group according to whether they were complicated with lung infection.1609 patients’ data from january 2016 to december 2018 served as the training set, and 1166 patients’ data from january 2019 to december 2020 served as the testing set.Demographics, whether the primary cancer was lung cancer, lung metastasis, the pathological classification of lung cancer patients, the number of metastases, history of surgery, history of chemotherapy, history of radiotherapy, history of central venous catheterization, history of hypertension, diabetes, and whether with myelosuppression were recorded.The presence of concurrent pulmonary infection was recorded and defined as the primary outcome variable.Stepwise forward algorithms were applied to informative predictors based on akaike’s information criterion.Multivariable logistic regression analysis was used to develop the nomogram.An independent testing dataset was used to validate the nomogram.Receiver-operating characteristic curves and the hosmer-lemeshow test were used to assess model performance.Results.The sample included 2755 patients with advanced cancer.An independently validated dataset included 1166 patients with advanced cancer.In the training dataset, gender, age, lung cancer as primary cancer, the pathological classification of lung cancer patients, history of chemotherapy, history of radiation therapy, history of surgery, the number of metastases, presence of central venous catheterization, and myelosuppression were identified as predictors and assembled into the nomogram.The area under curve demonstrated adequate discrimination in the validation dataset (0.77; 95% confidence interval, 0.74 to 0.79).The nomogram was well calibrated, with a hosmer-lemeshow χ 2 statistic of 12.4 ( p = 0.26 ) in the testing dataset.Conclusions.The present study has proposed an effective nomogram with potential application in facilitating the individualized prediction of risk of pulmonary infection in patients with advanced cancer.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Exosomes Derived from SW480-Resistant Colon Cancer Cells Are Promote Angiogenesis via BMP-2/Smad5 Signaling Pathway

Multidrug resistance is the main cause of tumor recurrence and metastasis.Therefore, it is urgent to explore the mechanism and treatment of drug resistance of tumor cells.We aim to investigate the relationship between drug resistance and angiogenesis in sw480 colon cancer cells and the possible underlying mechanism.Methods.Exosomes were extracted from sw480-sensitive or sw480-resistant colon cancer cells (sw480/oxaliplatin).The cck-8 assay, migration assay, tube formation assay, q pcr, and western blotting were performed in human umbilical vein endothelial cells (huvecs).The underlying mechanisms were detected by western blotting assays and bmp-2 si-rna silencing assay in vitro and in vivo.Results.The conditioned medium and exosomes of sw480/oxaliplatin cells promoted proliferation, migration, and tube formation of huvecs.The expression of bmp-2 released by sw480/oxaliplatin exosomes was 2.3-folds higher than that by sw480 exosomes.Additionally, exosomal bmp-2 inhibiting the smad signaling pathway induced the expression of vascular endothelial growth factor and cd31.Silencing of bmp-2 partly blocks the promoting effect of sw480/oxaliplatin exosomes on angiogenesis.Moreover, sw480/oxaliplatin cells increased the bmp-2 expression, consequently promoting angiogenesis in vivo.Conclusions.Sw480-resistant colon cancer exosomes promoted angiogenesis via the bmp-2/smad signaling pathway, which is potential for the novel treatment for antiangiogenic therapies in colon cancer.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Protective Effect of Schisandrin on CORT-Induced PC12 Depression Cell Model by Inhibiting Cell Apoptosis In Vitro

In recent years, the incidence of depression is on the rise.Our paper proposed to study the protective effects of schisandrin on cort-induced pc12 depressive cell model and the underlying mechanisms.Methods.The in vitro models of pc12 were established using corticosterone (cort).3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt) method was used to screen the effective concentration of schisandrin, and the models of pc12 were treated with low, medium, and high concentrations of schisandrin.The cell activity of each group was detected by mtt assay.The ldh activity in each group of cells was detected by lactate dehydrogenase (ldh) kit.Apoptosis rate of each group was detected by annexin v-fitc apoptosis assay kit.Mitochondrial membrane potential of each group of cells was detected by mitochondrial membrane potential kit.The protein expression levels of caspase-3, bax, and bcl-2 in each group of cells were detected by western blot.Results.The treatment of schisandrin significantly increased the cell viability in models of pc12.In addition, the results of ldh activity suggested that schisandrin significantly reduced ldh content in models of pc12.Consistently, schisandrin reduced the mitochondrial membrane potential of cort-induced pc12 depressive cell model.Furthermore, schisandrin effectively reduced the number of apoptotic cells and inhibited the expression of proapoptotic-related proteins (cleaved caspase-3 and bax) but increased the antiapoptotic-related protein (bcl-2) in the models of pc12.Conclusions.Protective effects of schisandrin on cort-induced pc12 depressive cell model by inhibiting cells apoptosis in vitro.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Ferroptosis in Macrophage Impairment in Sepsis

Sepsis is a clinical syndrome with high mortality, which can lead to multiple organ dysfunction syndrome.Nonspecific immune dysfunction and immune imbalance are its important pathological features.Macrophages are important immune cells and one of the important components of innate and adaptive immunity.Regulating the function of macrophages may be a potential method for the treatment of sepsis.Up to now, ferroptosis has been proved to be involved in the pathophysiological mechanism of many diseases, such as alzheimer’s disease, cancer, parkinson’s disease, and renal degeneration.At present, relevant studies have reported that ferroptosis may be involved in the occurrence of sepsis this paper reviews the existing mechanisms of iron ptosis in macrophages in sepsis, with a view to providing si’l for future studies on sepsis.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
The Intervention of Music Therapy on Behavioral Training of High-Functioning Autistic Children under Intelligent Health Monitoring

Autism is a serious and widespread developmental disorder in children.With the increase of autistic children every year, it is necessary to study a set of effective music therapy activities that can penetrate into life to help autistic children’s rehabilitation training.This paper aims to study the behavioral training of high-functioning autistic children with music therapy intervention under intelligent health monitoring.The autistic children were selected and divided into experimental group and control group.According to the psychological and physiological characteristics of five autistic children aged 5-7 years in the experimental group, the music therapy activity plan was designed, and the experimental intervention was carried out by combining individual music therapy and group music therapy.Compared with the control group, this paper explores the effect of music on the treatment of children with autism.The experimental results of this paper show that the language, social, cognitive, and behavioral problems of autistic children under music therapy under intelligent health monitoring have been significantly improved, and their emotional response ability has improved the most, increasing by 34%.Communication ability was next, increased by 20.3%; motor coordination ability increased by 20%; and cognitive ability improved by 11%.It can be explained that the four aspects of language, social interaction, cognition, and behavior have been significantly improved after music therapy.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Research Progress on the Relationship between Dietary Patterns and Hyperuricemia

As the final metabolite of purine metabolism, uric acid is critically associated with human health.The serum uric acid level is regulated by diet and the metabolic capacity of the human body.The impaired control of uric acid metabolism and excretion is associated with the increased level of serum uric acid, which ultimately results in hyperuricemia.Hyperuricemia is the “fourth-highest” after hypertension, hyperglycemia, and hyperlipidemia.With progress made in the relationship between diet and hyperuricemia, different dietary patterns and lifestyles have been discussed, such as exercise, the amount intake of meat, seafood, supplements with omega-3 fatty acids, sugar-sweetened soft drinks and energy drinks, and lower-fat-containing foods as well as drinking beer, wine, and spirits in the present article.This study demonstrated that a lower risk of hyperuricemia is substantially correlated with higher baseline adherence to me diet, and plant polyphenols can combat hyperuricemia by blocking xanthine oxidase.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;