syedzayyan/paper_mill_benchmark huggingface dataset:
Gut-Derived Metabolite, Trimethylamine-N-oxide (TMAO) in Cardio-Metabolic Diseases: Detection, Mechanism, and Potential Therapeutics.

Trimethylamine n-oxide (tmao) is a biologically active gut microbiome-derived dietary metabolite.Recent studies have shown that high circulating plasma tmao levels are closely associated with diseases such as atherosclerosis and hypertension, and metabolic disorders such as diabetes and hyperlipidemia, contributing to endothelial dysfunction.There is a growing interest to understand the mechanisms underlying tmao-induced endothelial dysfunction in cardio-metabolic diseases.Endothelial dysfunction mediated by tmao is mainly driven by inflammation and oxidative stress, which includes: (1) activation of foam cells; (2) upregulation of cytokines and adhesion molecules; (3) increased production of reactive oxygen species (ros); (4) platelet hyperreactivity; and (5) reduced vascular tone.In this review, we summarize the potential roles of tmao in inducing endothelial dysfunction and the mechanisms leading to the pathogenesis and progression of associated disease conditions.We also discuss the potential therapeutic strategies for the treatment of tmao-induced endothelial dysfunction in cardio-metabolic diseases.

Journal: Pharmaceuticals (Basel, Switzerland) (2023)
Publication types: Journal Article;Review
Coping Styles, Mental Health, and the COVID-19 Quarantine: A Nationwide Survey in Poland.

The outbreak of the novel coronavirus covid-19 that began from march 2020 is yet to be contained.Consequences of the ongoing pandemic may have a negative impact on the mental health of affected individuals.This particularly refers to those quarantined.Since the covid-19 pandemic is currently one of the biggest health issues worldwide, a higher demand emerges for research concentrating on the worsening of psychological well-being among the general and the quarantined population, as well as on individual coping strategies that may moderate the occurrence of psychopathologies.method:data were collected within the first weeks of the covid-19 pandemic in poland.Participants represented quarantine (+) and quarantine (-) groups.Quarantine (+) group, different from quarantine (-), consisted of people who experienced it themselves or someone close to them did after contacting an infected individual.To measure psychopathological symptoms a general health questionnaire (ghq-28) was used.For measuring ptsd symptoms, the impact of event scale-revised (ies-r) was used.This study followed the coping strategies manifested among the participants using the mini cope questionnaire.results:a total of 2,036 individuals participated in this study.Quarantine (+) individuals had significantly higher total and subscales ghq-28 scores (anxiety, insomnia, and somatic symptoms) as well as a higher ies-r arousal score.The quarantine (+) individuals were more likely to use self-distraction as a coping strategy.This research identified positive and negative correlations between presented coping styles and manifested psychopathology.conclusion:this nationwide study suggests occurrence of negative effects on mental health due to the covid-19 pandemic and quarantine.It is observed on most of the measured psychopathological symptoms.The present research provides a line of action that should be followed in the future in case of another epidemic and in the event restrictions like quarantine have to be introduced again.

Journal: Frontiers in psychiatry (2021)
Publication types: Journal Article
Immediate complications and flow volume changes during treatment phases of bronchial thermoplasty: a single-center descriptive study.

Introduction bronchial thermoplasty (b.t.) is a therapeutic bronchoscopic procedure in which controlled thermal energy is applied to the airway wall to decrease smooth muscle mass.Immediate complications of b.t.Include acute exacerbation of bronchial asthma, upper and lower respiratory tract infection, hemoptysis, among others.Our study assessed these immediate adverse events and the changes in forced expiratory volume in one second (fev1%) measured four hours after each procedure from baseline.The study also aimed to examine the number of activations during each cycle of treatment and its correlation to the corresponding change in fev1% from baseline.Methods a case-series analysis of 17 patients who underwent b.t.Between 2014 and 2019 was done.Demographic, clinical characteristics, including pre and post-bt fev1% measures, and the number of activations were obtained.Results acute exacerbation of asthma was the commonest complication accounting for 33%, 57%, and 75% after bt1, bt2, and bt3, respectively.There was deterioration in fev1% after each treatment phase, the most significant being in bt3.There was no correlation between the number of heat activations with the change in fev1% from baseline.Conclusion the number of activations in b.t.Does not correlate with the immediate deterioration in fev1%, although exacerbation of asthma is the commonest complication post-b.t.

Journal: The Journal of asthma : official journal of the Association for the Care of Asthma (2022)
Publication types: Journal Article
Examining the impact of sharing COVID-19 misinformation online on mental health.

Misinformation about the covid-19 pandemic proliferated widely on social media platforms during the course of the health crisis.Experts have speculated that consuming misinformation online can potentially worsen the mental health of individuals, by causing heightened anxiety, stress, and even suicidal ideation.The present study aims to quantify the causal relationship between sharing misinformation, a strong indicator of consuming misinformation, and experiencing exacerbated anxiety.We conduct a large-scale observational study spanning over 80 million twitter posts made by 76,985 twitter users during an 18.5 month period.The results from this study demonstrate that users who shared covid-19 misinformation experienced approximately two times additional increase in anxiety when compared to similar users who did not share misinformation.Socio-demographic analysis reveals that women, racial minorities, and individuals with lower levels of education in the united states experienced a disproportionately higher increase in anxiety when compared to the other users.These findings shed light on the mental health costs of consuming online misinformation.The work bears practical implications for social media platforms in curbing the adverse psychological impacts of misinformation, while also upholding the ethos of an online public sphere.

Journal: Scientific reports (2022)
Publication types: Journal Article;Observational Study;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.;Research Support, N.I.H., Extramural
The influence of different patient positions on the preoperative 3D planning for surgical resection of soft tissue sarcoma in the lower limb-a cadaver pilot study.

Introduction complete surgical resection remains the mainstay of the treatment of soft tissue sarcomas.Intraoperative positioning of the patient is dictated by tumor location, whereas preoperative imaging is always performed in the supine position.The effect of changing the patient position on the exact location of the tumor with regard to neurovascular structures and bone is unknown.Material and methods two fresh frozen cadavers (pelvis and legs) were thawed and warmed.Three standardized tumor models were implanted in the thigh and calf.Mr/ct images of the cadavers were obtained sequentially in four different patient positions.The minimal distance of each "tumor" to neurovascular structures was measured on axial mr images and the 3d shift of the center of the tumor to the bone was measured after segmentation of the ct images.Results a significant difference of the minimal distance of the "tumor" to the femoral artery (p = 0.019/0.023) and a significantly greater number of deviations of more than 5mm/10 mm in the thigh between the supine position and the other positions compared to two supine positions (p = 0.027/0.028) were seen.The center of the "tumor" compared to the bone shifted significantly in the thigh (p < 0.001/0.002) but not the lower leg.Conclusion obtaining images in the same patient position as the planned tumor resection may become particularly relevant if computer assisted surgery, which is based on preoperative imaging, is introduced into soft tissue sarcoma surgery as the patient position significantly influences the spatial position of the tumor.

Journal: Surgical oncology (2020)
Publication types: Journal Article
An extreme learning machine optimized by differential evolution and artificial bee colony for predicting the concentration of whole blood with Fourier Transform Raman spectroscopy.

Raman spectroscopy, with its advantages of non-contact nature, rapid detection, and minimum water interference, is promising for non-invasive blood detection or diagnosis in clinic applications.However, there is a critical issue that how to accurately analyze blood composition by raman spectroscopy.In this study, we apply extreme learning machine (elm) algorithm and a multivariate calibration regression model to analyze the results from raman spectroscopy and determine the component's concentrations in blood samples, including glucose, cholesterol, and triglyceride.Self-adaption differential evolution artificial bee colony (sadeabc) algorithm was further applied to increase the data's accuracy and robustness.The obtained data for coefficient of determination, root mean square error of calibration, root mean square error of prediction, and relative percent deviation, were 0.9822, 0.3993, 0.3827, and 6.6679 for glucose, 0.9786, 0.2104, 0.2088 and 5.9533 for cholesterol, and 0.9921, 0.2744, 0.3433 and 10.5075 for triglyceride, respectively.Results demonstrated that the model based on sadeabc-elm show much better prediction data than those models based on the elm and abc-elm.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2023)
Publication types: Journal Article
Approaches to interpersonal conflict in simulation debriefings: A qualitative study.

Context conflict during simulation debriefing can interfere with learning when psychological safety is threatened.Debriefers often feel unprepared to address conflict between learners and the literature does not provide evidence-based guidance within the simulation setting.The purpose of this study was to describe debriefers' approach to mediating interpersonal conflict and explore when, why and how they adopt mediation strategies.Methods we performed a secondary analysis of qualitative data collected as part of a larger study examining simulation debriefers' approaches to debriefing scenarios with different learner characteristics.For this study, we applied thematic analysis to transcripts from simulated debriefings (n = 10) and the associated pre-simulation (n = 11) and post-simulation (n = 10) interviews that focused on interpersonal conflict between learners.Results debriefers described struggling with mediating conflict and the importance of self-awareness.Specific mediation strategies included intervening, addressing power relations, reconciling unproductive differences, leveraging different perspectives, circumventing the conflict, and shifting beyond the conflict; each of these strategies encompassed a number of particular skills.Situations that triggered a mediation approach were related to psychological safety, emotional intensity, and opportunities for shared understanding and productive learning.Debriefers applied mediation strategies and skills in a flexible and creative way.Conclusions the strategies we have described for mediating interpersonal conflict between learners in simulation debriefing align with notions of psychological safety and may be useful in guiding future professional development for simulation educators.

Journal: Medical education (2021)
Publication types: Journal Article
The prevalence of inverse health consequences of COVID-19 vaccines: A post-vaccination study.

Covid-19 vaccinations are intended to help produce neutralizing antibodies which target surface spike protein to combat the sars-cov-2 virus.Similarly, covid-19 recovered patients exhibit high levels of sars-co v-2 neutralizing antibodies, which predominantly target the surface spike protein and are associated with the occurrence of health consequences in survivors.Objective the aim of the study is to explore the long-term health consequences of the covid-19 vaccines.Methodology a prospective, exploratory observational study conducted both online and offline using various questionnaires with all immunized individuals who had been inoculated for at least a month following their last covid-19 vaccine either azd1222® or bbv152® vaccines.Results we evaluated 258 individuals who had taken the covid vaccine and found that females made up the majority (54.3%) and that the mean age was 24 years.Post-vaccination long-term health issues were reported by 36.05% (93) of the participants, with 37.86% (53) of females and 33.9% (40) of males (p = 0.292).Myalgia was reported by 20.15% (52), fatigue was 13.95% (36), paresthesia was 1.16% (3), ageusia was 0.77% (2), sadness/irritability was 2.31% (6), and lack of concentration/excessive worry was 3.1% (8).Conclusions myalgia, fatigue, paresthesia, ageusia, coughs and colds, dyspnea, sadness/irritability, and lack of concentration/excessive worry are health consequences related to the covid-19 vaccination which follow a similar pattern of post-covid syndrome.

Journal: Vacunas (2022)
Publication types: Journal Article
Surgical management of os odontoideum: An Algerian center experience.

Os odontoideum (oo) is a craniovertebral junction malformation of unknown origin.In most times, this lesion is highly unstable demanding surgical management.We present our series of oo surgical management and we discuss clinical, radiological, and management aspects of this pathology via our experience and literature opinions.Methods this is a retrospective study of patients operated on at our department between may 2014 and may 2021 for oo.All patients were explored with plane x-rays and computed tomography (ct).In some cases, magnetic resonance imaging (mri) was necessary.Posterior c1-c2 or c1-c3 fixation with polyaxial screws and rod fixation was used.In postoperative, the patient is asked to put philadelphia collar for 3 months.Hospitalization periods vary between 3 and 7 days.After discharge, all our patients are followed up regularly in consultation.Control radiographs of the occipito cervical region were performed.After 3 months postoperatively, the ct scan is performed on all our patients to assess the quality of fusion.Patient's follow-up ranges from 4 months to 6 years.Results fifteen patients were included in this study; nine males (60%) and six females (40%); with mean age of 32.5 years old.Ten patients (67%) presented motor weakness, three patients (20%) with neck pain, one patient (6.5%) with torticollis, and one patient (6.5%) presented vertigo.No notable cervical trauma was present in six patients (40%) and in nine patients (60%), a remote history of traumatism was noted.All cases of our series presented mobile oo.Normal thickness of the c2 pedicle was noted in nine patients (60%).In two patients (13%), there was hypoplasia of one pedicle and in four patients (27%) both pedicles.Mri showed direct signs of spinal cord aggression: simple compression, myelomalacia, strangulation, or hypotrophy.C1 lateral mass screw fixation was performed in all patients; and according to c2 morphology: nine patients underwent c1-c2 pedicular fixation, in one patient, bilateral crossing c2 laminar screws technique, in three patients, we skipped c2 to perform a c1-c3 articular fixation, and in two patients, c1-c2-c3 fixations were performed.All patients improved clinically.In one patient, we noted an infection resulting in bad wound healing this infection was successfully treated with no complications.In the patient with bilateral crossing c2 laminar screws technique, ct control objectified 4 mm exceeding of one screw; the patient was reoperated and the screw was slightly pulled back.No other complications were noted.Conclusion congenital origin of oo is always evoked.C1-c2 fixation according to goel and harms technique with grafting proved its safety, providing high fixation quality with the acceptable biodynamic outcome.Once treated, the prognostic of oo is in general good, and improvement is observed in most patients with few complications.

Journal: Journal of craniovertebral junction & spine (2022)
Publication types: Journal Article
An Efficient Feedback Control Mechanism for Positive/Negative Information Spread in Online Social Networks.

The wide availability of online social networks (osns) facilitates positive information spread and sharing.However, the high autonomy and openness of the osns also allow for the rapid spread of negative information, such as unsubstantiated rumors and other forms of misinformation that often elicit widespread public cognitive misleads and huge economic losses.Therefore, how to effectively control the negative information spread accompanied by positive information has emerged as a challenging issue.Unfortunately, this issue still remains largely unexplored to date.To fill this gap, we propose an efficient feedback control mechanism for the simultaneous spread of the positive and negative information in osns.Specifically, a novel computational model is first proposed to present the temporal dynamics of the positive and negative information spread.Furthermore, the proposed mechanism restrains the negative information spread with minimal system expenses by devising and performing three synergetic intervention strategies.Technically, this mechanism intensively evaluates the number of seed users performing three intervention strategies.Besides, each seed user performs the received control task independently, and then the control plan for the next time step is adjusted dynamically according to the previous feedback results.Finally, we evaluate the efficiency of the proposed mechanism based on the extensive experimental results obtained from two real-world networks.

Journal: IEEE transactions on cybernetics (2022)
Publication types: Journal Article
Comparative effect of seven prophylactic locks to prevent biofilm biomass and viability in intravenous catheters.

Patients requiring long-term intravenous access are at risk of intraluminal catheter bloodstream infection.'prophylactic' locks aim to limit this risk but there is uncertainty regarding the most effective lock.Objectives to develop a novel technique intended to replicate clinical procedures to compare the effectiveness of various 'prophylactic' locks against biofilm biomass ('biomass') formation and biofilm viability ('viability') of escherichia coli and staphylococcus epidermidis in intravenous catheters.Methods for 10 consecutive days 106 cfu/m l e.Coli nctc 10418 and s.Epidermidis atcc 12228 were separately cultured in single lumen 9.6 french silicone tunnelled and cuffed catheters.These were flushed with 0.9% w/v sodium chloride using a push-pause technique before and after instillation of seven 'prophylactic' locks (water, ethanol, sodium chloride, heparinized sodium chloride, citrate, taurolidine plus citrate, and taurolidine; each in triplicate) for 6 h daily.Intraluminal 'biomass' and 'viability' were quantified using crystal violet staining and flush culture, respectively.Results the reduction of 'biomass' and 'viability' depended on both agent and species.Citrate was least effective against e.Coli 'viability' and 'biomass' but most effective against s.Epidermidis 'viability', and taurolidine was most effective against e.Coli 'biomass' and 'viability' but least effective against s.Epidermidis 'viability'.'biomass' and 'viability' were significantly correlated in e.Coli between (r = 0.997, p < 0.001) and within (r = 0.754, p = 0.001) interventions, but not in s.Epidermidis.Conclusions a novel technique found the effect of 'prophylactic' agents in reducing 'biomass' and 'viability' varied by species.The choice of agent depends on the most likely infecting organism.

Journal: The Journal of antimicrobial chemotherapy (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Differential Neutralization of Apixaban, Betrixaban, Edoxaban, and Rivaroxaban by Andexanet Alfa as Measured by Whole Blood Thromboelastographic Analysis.

Introduction the available oral anti-xa agents are routinely used for the management of thrombotic disorders.A molecularly modified recombinant coagulation fxa, also known as andexanet alfa (aa), that has been developed as an antidote to neutralize the bleeding effects of oral fxa inhibitors, such as apixaban and rivaroxaban.Materials and methods this study utilized thromboelastography (teg 5000 hemostasis system), to investigate the neutralizing effects of aa at different concentrations of oral fxa inhibitors measuring such parameters as r-time, k-time, angle, and max amplitude (ma).Apixaban, betrixaban, edoxaban, and rivaroxaban were obtained commercially in powdered form.Each of these drugs was supplemented with freshly drawn whole citrated blood at a concentration of 1 μg/m l.And subsequently mixed with aa at 50 or 100 μg/m l.Results at a concentration of 1 μg/m l, all fxa inhibitors produced variable anticoagulant effects in the order of edoxaban > betrixaban > rivaroxaban > apixaban.Aa at 100 μg/m l produced a complete neutralization of these inhibitors whereas at 50 μg/m l relatively weaker neutralization as measured by various parameters.Conclusion these results suggest that regardless of the variable anticoagulant effects exhibited by the fxa inhibitors, aa at fc = 100 μg/m l fully neutralized these agents as measured by the teg parameters.Aa was shown to be more effective in neutralizing betrixaban and least effective in apixaban.The neutralization of various fxa inhibitors was dose and donor-dependent warranting dosage adjustment for optimal outcomes.

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (2022)
Publication types: Journal Article
p53 Isoforms as Cancer Biomarkers and Therapeutic Targets.

This review aims to summarize the implications of the major isoforms of the tumor suppressor protein p53 in aggressive cancer development.The current knowledge of p53 isoforms, their involvement in cell-signaling pathways, and their interactions with other cellular proteins or factors suggests the existence of an intricate molecular network that regulates their oncogenic function.Moreover, existing literature about the involvement of the p53 isoforms in various cancers leads to the proposition of therapeutic solutions by altering the cellular levels of the p53 isoforms.This review thus summarizes how the major p53 isoforms δ40p53α/β/γ, δ133p53α/β/γ, and δ160p53α/β/γ might have clinical relevance in the diagnosis and effective treatments of cancer.

Journal: Cancers (2022)
Publication types: Journal Article;Review