syedzayyan/paper_mill_benchmark huggingface dataset:
Two Zinc(II) and Nickel(II)-based Complexes: Anti Breast Cancer Activity

Two zinc(ii) and nickel(ii) based coordination polymers, {[zn(bibp)(mo o 4 )](h 2 o) 2 } n ( 1 ) [bibp = 4,4′‐bis(imidazol‐1‐yl)‐biphenyl] and [ni 2 (cn) 4 (phen) 2 ] n ( 2 ) (phen = 1,10‐phenanthroline), were synthesized and structurally characterized under solvothermal conditions.Compound 1 can be viewed as the connection of the 1d w ‐type chain [zn( trans ‐bibp)] with the mo o 4 2– anion to form a uninodal 4‐connected net, whereas 2 features one‐dimensional ni ii cyanide chains decorated either with linear ni(cn) 4 side chains or with 1,10‐phenanthroline ligands bound directly to the ni ii sites of the parent chain.In addition, in vitro anticancer activities of compounds 1 and 2 on four human breast cancer cells (mda‐mb‐231, mda‐mb‐468, sk‐br‐3, and mcf7) was further determined.

Journal: ZAAC: Zeitschrift für anorganische und allgemeine Chemie (Journal of Inorganic and General Chemistry) (2017)
Publication types: Research Article;
Ultrasonic Elastography Combined with Human Papilloma Virus Detection Based on Intelligent Denoising Algorithm in Diagnosis of Cervical Intraepithelial Neoplasia

The aim of this research was to study the application of ultrasonic elastography combined with human papilloma virus (hpv) detection based on bilateral filter intelligent denoising algorithm in the diagnosis of cervical intraepithelial neoplasia (cin) and provide a theoretical basis for clinical diagnosis and treatment of cin.In this study, 100 patients with cervical lesions were selected as research objects and randomly divided into control group and experimental group, with 50 cases in each group.Patients in control group and experimental group were diagnosed by ultrasonic elastography combined with hpv detection.The experimental group used the optimized image map of bilateral filter intelligent denoising algorithm for denoising and optimization, while the control group did not use optimization, and the differences between them were analyzed and compared.The diagnostic effects of the two groups were compared.As a result, the three accuracy rates of the experimental group were 95%, 95%, and 98%, respectively; the three sensitivity rates were 96%, 92%, and 94%, respectively; and the three specificity rates were 99%, 97%, and 98%, respectively.In the control group, the three accuracy rates were 84%, 86%, and 84%, respectively; the three sensitivity rates were 88%, 84%, and 86%, respectively; and the three specificity rates were 81%, 83%, and 88%, respectively.The accuracy, sensitivity, and specificity of experiment group were significantly higher than those of control group, and the difference was statistically significant ( p &lt; 0.05 ).In summary, the bilateral filter intelligent denoising algorithm has a good denoising effect on the ultrasonic elastography.The ultrasonic image processed by the algorithm combined with hpv detection has a better diagnosis of cin.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
Encapsulation of 5-Fluorouracil in a Copper(II)-based Porous Metal-organic Framework: Drug Delivery and Inhibiting Human Spinal Cord Tumor Cells

Solvothermal reaction of a semirigid tricarboxylic acid with cu(no 3 ) 2 · 3h 2 o gives rise to a robust microporous metal‐organic framework with the formula {[cu 2 (oh)bcb](dmf) 2 (h 2 o) 3 } n ( 1 ) [h 3 bcb = 3,5‐bis((4′‐carboxylbenzyl)‐oxy)benzoic acid, dmf = n , n ‐dimethylformamide].Its structure was determined by single‐crystal x‐ray diffraction analysis and further characterized by elemental analysis, powder x‐ray diffraction (pxrd), and thermogravimetric (tg) analyses.The efficient encapsulation of an anticancer drug 5‐fluorouracil (5‐fu) on the desolvated 1 ( 1a ) was studied by both grand canonical monte carlo (gcmc) simulation and drug release experiments.In addition, in vitro anticancer activity of compounds 1 and 5‐fu loaded 1a were also evaluated using mtt assay.

Journal: ZAAC: Zeitschrift für anorganische und allgemeine Chemie (Journal of Inorganic and General Chemistry) (2018)
Publication types: Research Article;
Treatment and Impacts of Chronic Sinusitis with the Confluence of Biyuan Tongqiao Granules and Saline Nasal Irrigation

In this research study, we will study the clinical effect of biyuan tongqiao granules with saline nasal irrigation for treatment of chronic sinusitis.It will also study its impacts on the computed tomography (ct) score of the nasal sinus and negative reactions in patients.For this purpose, ninety (90) patients with chronic sinusitis were admitted to the hospital (june 2019 to june 2020).They were selected as the research subjects and divided into experimental and control groups randomly with 45 cases in each group.Control group patients were treated with nasal irrigation with normal saline.While, biyuan tongqiao granules combined with nasal irrigation with normal saline was treated by the experimental group.The ct scores of nasal sinus, clinical effect, the incidence of adverse reactions, recurrence rate, duration of nasal mucosal epithelialization, and nasal ciliary transmission speed of both the groups were compared.The patients’ pain was assessed by the visual analogue scale (vas), and the symptoms of sinusitis were scored by the snot-20 scale.The experimental group showed significantly lower sinus ct scores and better clinical effects.Adverse reactions were not observed in both the groups’ probability ( p &gt; 0.05 ).The experimental group presented a significantly lower recurrence rate, shorter duration of nasal mucosal epithelialization, faster nasal ciliary transmission, and sharply lowers vas scores and snot-20 scores than in the control group ( p &lt; 0.05 ).This proves biyuan tongqiao granules and nasal irrigation with normal saline can effectually boost the clinical efficacy and lessen the computed tomography score of nasal sinus in chronic sinusitis patients.It has a worthy clinical application and promotion.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Clinical Study;
A Porous Zn2(abct) Framework as an Efficient Carrier for 5-Fu Delivery and Inhibiting Human Liver Cancer Cells

The creation of effective drug delivery systems is very important in diagnosis and treatment of cancer through controlled and targeted drug delivery.They can increase bioavailability of drugs and reduce their side effects.Metal‐organic frameworks (mofs) are alternative drug delivery systems, which are suitable for targeted drug delivery due to their adjustable pore sizes and compatibility by adding some functional groups.In this work, a new porous zn ii ‐organic framework was fabricated using a tetracarboxylic acid linker 3,3′,5,5′‐azobenzene‐tetracarboxylic acid (h 4 abct), which reveals a 3d channel‐type framework with a high free pore volume.The performance of the solvent‐free samples was studied on absorbing and releasing 5‐fluorouracil (5‐fu).Characterization methods, such as ft‐ir, pxrd, hplc, bet measurement, and gcmc simulations, were employed to characterize the 5‐fu loaded framework.Furthermore, anticancer properties of the mof and drug‐loaded mof were investigated against four human liver cancer cells (hep g2, smmc‐7721, hu h‐7 and mhcc‐97h).

Journal: ZAAC: Zeitschrift für anorganische und allgemeine Chemie (Journal of Inorganic and General Chemistry) (2018)
Publication types: Research Article;
To Study the Effect of Individualized Nursing Model Based on MDT Concept on Limb Function Recovery and Quality of Life in Patients with Breast Cancer

To study the value of the individualized nursing model based on the concept of multidisciplinary team (mdt) on recovery of limb function and quality of life in patients with breast cancer.Methods.A total of 110 breast cancer patients admitted to our hospital from january 2021 to december 2021 were selected as the research objects.The 110 breast cancer patients were divided into the research group ( n = 55 ) and the control group ( n = 55 ) according to the random number table method.The control group received routine care.The research group implemented individualized nursing based on the mdt concept on the basis of routine nursing.The disabilities of the arm, shoulder, and hand (dash) scores before nursing and 1 month after nursing were studied in the two groups, hamilton anxiety scale (hama) score, hamilton depression scale (hamd) score, and functional assessment of cancer therapy-b (fact-b) score.Results.After 1 month of nursing, the dash score of the research group was lower than that of the control group, and the difference was statistically significant ( p &lt; 0.05 ), and after 1 month of nursing, the hama score of the research group was lower than that of the control group ( p &lt; 0.05 ).After 1 month of nursing, the hamd scale score of the research group was lower than that of the control group, and the difference was statistically significant ( p &lt; 0.05 ).After 1 month of nursing, the fact-b score of the research group was higher than that of the control group, and the difference was statistically significant ( p &lt; 0.05 ).Conclusion.The individualized nursing model based on the mdt concept has high application value for breast cancer patients.This nursing model can improve the function of limb movement, relieve the patient’s anxiety and depression, and improve the patient’s quality of life.This nursing model is worthy of clinical promotion.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Porous GdIII-Organic Framework as a Dual-Functional Material for Cyanosilylation of Aldehydes and Ablation of Human Liver Cancer Cells

Metal‐organic frameworks (mofs) have gained great attention in recent years because they could behave as multifunctional materials which combine the advances of porous solids and coordination complexes.With the aim of constructing multifunctional mofs, in this study, we choose a y‐shaped tricarboxylic ligand biphenyl‐3,4′,5‐tricarboxylic acid (h 3 bpt) to react with gd iii ions to afford a new dual‐functional lanthanide‐organic framework with the chemical formula of [gd 2 (bpt) 2 (h 2 o) 2 ] · (dmf) 2 (h 2 o) 6 ( 1 ) (dmf = n , n ‐dimethylformamide) under solvothermal condition.The title complex was characterized by means of elemental analysis, ft‐ir spectroscopy, thermogravimetric and x‐ray diffraction analyses.Crystal structure analysis reveals that compound 1 is composed of 1d helical chain secondary building units that connect by the bpt 3– ligands into a 3d framework with 1d nanosized channels running along the b axis.In view of its high porosity and accessible open metal sites, the activated 1 ( 1a ) was studied for the cyanosilylation of aldehydes under solvent‐free conditions.The catalytic activity of 1a is much higher than that of compound 1 , indicating that the exposed open metal sites of 1a is beneficial to the cyanosilylation reaction.In connection to these, the different cytotoxicities of 1 and 1a were also evaluated on four human liver cancer cells (smmc‐7721, bel‐7402, mhcc97 and hep3b) by the mtt assay.

Journal: ZAAC: Zeitschrift für anorganische und allgemeine Chemie (Journal of Inorganic and General Chemistry) (2019)
Publication types: Research Article;
To Investigate the Effect of Glucocorticoids on Blood Loss during and after First Total Hip Arthroplasty and Its Safety Meta-Analysis

To evaluate the efficacy and safety of topical glucocorticoids for total hip arthroplasty by meta-analysis.Methods.A computerized search of the cochrane library, medline, embase, and pub med english databases, as well as chinese biomedical literature database, vipu chinese science and technology journal database, wanfang database, and chinese knowledge net database, was performed to include all randomized controlled trials (rcts) regarding topical glucocorticoid therapy for postoperative bleeding after tha according to the inclusion criteria.The quality evaluation criteria of rcts, as stated in the cochrane handbook for systematic reviews of interventions 4.2.5, were adopted for evaluation, and the meta-analysis was performed using rev man 5.3.Results.A total of 10 articles were included, including 1,112 patients: 566 in the topical glucocorticoid group and 546 in the control group.The transfusion rate was 8.43% for topical glucocorticoids and 30.05% for the control group ( p &lt; 0.001 ), and topical glucocorticoids reduced 317.89 ml total blood loss and 76.82 ml invisible blood loss, with statistically significant differences ( p &lt; 0.001 ).The amount of intraoperative blood loss was reduced by topical glucocorticoids, but the difference was not statistically significant ( p = 0.83 ), and the postoperative hb value was increased by topical glucocorticoids, although the difference was statistically significant ( p &lt; 0.001 ).The incidence of dvt and pe after topical glucocorticoid application (3.03%) was greater than that of the control group (2.40%), the difference was not statistically significant ( p = 0.54 ), and the incidence of infection after topical glucocorticoid application (3.03%) was greater than that of the control group (2.40%).The difference was not statistically significant ( p = 0.39 ).Conclusions.Topical glucocorticoids can reduce the transfusion rate and blood loss in tha patients without increasing their risk of thrombosis.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Meta-Analysis;
Three-Dimensional Skin CT Based on Intelligent Algorithm in the Analysis of Skin Lesion Sites Features in Children with Psoriasis

This research was to explore the application value of three-dimensional computed tomography (ct) based on artificial intelligent algorithm in analyzing the characteristics of skin lesions in children with psoriasis.In this study, 15 children with psoriasis were selected as the observation group, and 15 children with other skin diseases were selected as the control group.The ct images were optimized, and the feature selection was carried out based on artificial intelligent algorithm.Firstly, the results were compared with the results of simple skin three-dimensional ct to determine the effectiveness.Then, the two groups of three-dimensional skin ct image features of skin psoriasis-like hyperplasia, munro microabscess, dermal papillary vascular dilation, and squamous epithelium based on intelligent algorithms were compared.After comparison, the detection rate of psoriasis-like hyperplasia, munro microabscess, dermal papillary vascular dilation, and squamous epithelium in the observation group was higher than that in the control group, with significant difference and statistical significance ( p &lt; 0.05 ).In addition, the sensitivity of psoriasis-like hyperplasia, munro microabscess, dermal papilla vascular dilatation, and squamous epithelium in children with psoriasis was 80.0%, 86.7%, 80.0%, and 93.3%, respectively.The specificity of psoriasis-like hyperplasia, munro microabscess, dermal papilla vascular dilatation, and squamous epithelium in children with psoriasis was 86.7%, 93.3%, 60.0%, and 73.3%, respectively.The results showed that munro microabscess and psoriasis-like hyperplasia had high sensitivity and specificity in all diagnostic items, which could be used as important features of skin lesion sites in the diagnosis of psoriasis in children.The research provides a basis for the clinical diagnosis of psoriasis in children, which is worthy of clinical promotion.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Three Potential Tumor Markers Promote Metastasis and Recurrence of Colorectal Cancer by Regulating the Inflammatory Response: ADAM8, LYN, and S100A9

Metastasis and recurrence are major causes of colorectal cancer (crc) death, but their molecular mechanisms are unclear.In this study, genes associated with crc metastasis and recurrence were identified by weighted gene coexpression network analysis, selecting the top 25% most variant genes in the dataset gse33113.By average linkage hierarchical clustering, a total of 21 modules were generated.One key module was identified as the most relevant to the prognosis of crc.Gene ontology analysis indicated that genes associated with tumor metastasis and recurrence in this module were significantly enriched in inflammatory biological functions.Functional analysis was performed on the key module, and candidate hub genes (adam8, lyn, and s100a9) were screened out by expression and survival analysis.In summary, the three core genes identified in this study could greatly improve our understanding of crc metastasis and recurrence.The results also provide a theoretical basis for the use of three core genes (adam8, lyn, and s100a9) as a combined marker for early diagnosis, which could benefit crc patients.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
The Value of CT Perfusion Parameters and Apparent Diffusion Coefficient Value of Magnetic Resonance Diffusion Weighted Imaging in Diagnosis of Hepatocellular Carcinoma

Hepatocellular carcinoma is one of the malignant tumors with the highest incidence in the world.According to the latest statistics of the national cancer center, the incidence of liver cancer ranks fifth in malignant tumors and its mortality rate ranks second in china, which seriously threatens people’ s life and health.Aim.To investigate the value of ct perfusion parameters and apparent diffusion coefficient (adc) of magnetic resonance imaging (mri) diffusion weighted imaging (dwi) in the diagnosis of hepatocellular carcinoma.Methods.43 patients with hepatocellular carcinoma and 40 patients with hepatic hemangioma treated in our hospital from august 2018 to august 2021 were selected for ct perfusion imaging and mri examination.Results.The liver blood flow (bf), liver blood volume (bv), and hepatic artery perfusion (hap) in the hepatocellular carcinoma group were (267.38 ± 35.59) ml/(min·100 g), (30.20 ± 8.82) ml/100 g, and (0.64 ± 0.10) ml/(min·ml), respectively, which were significantly higher than those in the hepatic hemangioma group ( p &lt; 0.05 ).The adc value of hepatocellular carcinoma dwi sequence was (1.20 ± 0.17) ×10-3 mm2, which was significantly lower than that of hepatic hemangioma ( p &lt; 0.05 ).The area under roc curve of bf, bv, hap, and adc values for hepatocellular carcinoma was 0.860, 0.754, 0.804, and 0.890, respectively.The area under roc curve of the four groups was compared ( p &gt; 0.05 ).Conclusion.Ct perfusion parameters bf, bv, hap, and dwi sequence adc values have certain application value in the diagnosis of hepatocellular carcinoma, and there is no significant difference between the diagnostic value of each parameter.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
The Value of CT Angiography Based on Intelligent Segmentation Algorithm for Survival of Hemodialysis Patients

This study was to explore the application value for central venous stenosis and occlusion in hemodialysis patients under the ct angiography based on intelligent segmentation algorithm, so that patients can survive better.Spiral ct was used to examine upper limb swelling in 62 uremic hemodialysis patients at a speed of 3.8 m l/s.Nonionic iodine contrast agent was injected around the contralateral limb.The total dosage of 90-102 m l, it was scanned by intelligent trigger technology.The trigger scanning threshold was set.The monitoring point was located in the superior vena cava.Ct with convolutional neural network intelligent segmentation algorithm was used to process image data.Finally, the quality of life and related biochemical levels of patients before and after hemodialysis were detected.Under the ct angiography of intelligent segmentation algorithm, 77 stenoses were found in 62 uremic patients, including 48 stenoses of the brachial vein and 17 stenoses of the superior vena cava.The correlation coefficient between ct angiography and digital subtraction angiography (dsa) imaging results of intelligent segmentation algorithm was 0.411.Segmentation effect of the algorithm in this study: automatic segmentation accuracy was greater than 79%.After hemodialysis treatment, the scores of physical fitness, pain, social function, and energy status of patients were significantly increased compared with those before treatment, and the levels of albumin, serum phosphorus, and parathyroid hormone were significantly decreased ( p &lt; 0.05 ).In summary, ct angiography with intelligent segmentation algorithm can obtain clear, intuitive, and complete vascular walking images, and better display subclavian vein, brachiocephalic vein, and superior vena cava.It can provide more valuable support for surgical intervention and has certain application value for better survival of hemodialysis patients.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
The Significance of Implementing Bilevel Positive Airway Pressure under Cluster Nursing in Improving the Survival Possibility of Patients with Severe Pulmonary Infection Complicated by Respiratory Failure

To explore the significance of bilevel positive airway pressure (bipap) under cluster nursing in improving the survival probability of patients with severe pulmonary infection (spi) complicated by respiratory failure (rf).Methods.This research included 153 spi patients complicated by rf ( spi + rf ) admitted between january 2020 and march 2022, including 55 cases in group a who were treated with bipap under cluster care during hospitalization, 47 cases in group b receiving invasive continuous mechanical ventilation during hospitalization, and 51 cases in group c treated with bipap under routine care during hospitalization.The three cohorts were compared regarding pre- and posttreatment serum inflammatory factors (ifs), blood gas (bg) parameters, heart rate (hr), and respiratory rate (rr).Besides, the cumulative time of ventilator use, successful ventilator weaning rate, mortality, and incidence of adverse events were counted.Finally, patients were scored for their psychological state using the hamilton anxiety/depression scale (hama/hamd).Results.The posttreatment tnf-α, il-6, pct, wbc, and pa co2 reduced statistically in all the three groups, with the lowest levels found in group a and the highest in group b ( p &lt; 0.05 ); while pa o2 and sp o2 increased, with the highest values found in group a and the lowest in group b ( p &lt; 0.05 ).Among the three groups, group a had the shortest duration of ventilator use, the highest successful weaning rate, and the lowest incidence of adverse events ( p &lt; 0.05 ).Besides, hama and hamd scores were the lowest in group a among the three groups, while those in group b were higher compared with group c ( p &lt; 0.05 ).Conclusion.The implementation of bipap under cluster nursing can effectively reduce inflammatory responses of spi + rf patients, improve their vital signs, and enhance their psychological state, which has extremely high clinical application value.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;