syedzayyan/paper_mill_benchmark huggingface dataset:
Orbital anatomy magnetic resonance imaging in diplopic versus non-diplopic patients after glaucoma drainage device placement.

New-onset persistent diplopia has become a common complication after glaucoma drainage device (gdd) placement.Understanding the orbital anatomy of such patients may provide information regarding risk of diplopia, gdd selection, and post-operative management.The purpose of this study was to examine the orbital anatomic differences in diplopic and non-diplopic patients after gdd implantation using high-resolution mri.Methods seven eyes (n= 4 with diplopia and n= 3 without diplopia after gdd placement) of seven patients that had undergone placement of baerveldt 250 (b250), baerveldt 350 (b350), or ahmed fp7 (fp7) gdd were prospectively enrolled at a single institution.All patients underwent a 3.0t orbital mri with 3d volumetric t1 and t2 weighted sequence.Images were analyzed for orbital volume, axial length, orbital distances, presence of superior rectus-lateral rectus (sr-lr) band, position of gdd, and sr-lr angles.Results patients with diplopia had smaller mean ± sd orbital axial (911.5 ± 111.8 mm3vs 931.7 ± 79.7 mm3) and coronal volumes (1162.5 ± 145.5 mm3vs 1180 ± 34.6 mm3) compared to non-diplopic patients.Average orbital rim distances were larger for the diplopic group.The sr-lr displacement angle for diplopic patients was larger (101.6° ± 8.1 vs 94.7° ± 17.6) while the sr-lr quadrantic angle (86.6° ± 4.2 vs 89.1° ± 4.3) was smaller.Sr-lr band was present and intact in all patients.Gdd malpositioning was not evident in any patient.Conclusion the decreased orbital axial and coronal volumes as well as increased orbital rim distances in diplopic patients suggests the need for further studies to understand the role of orbital anatomy in occurrence of diplopia.Dynamic mri imaging may be helpful in identifying differences in extraocular muscle function that reveal an etiology of diplopia in patients with gdd implantation.

Journal: European journal of ophthalmology (2022)
Publication types: Journal Article
Evaluation of Telephone-Based Cardiac Rehabilitation Services Delivered to Adults 65 and Older During the Early Months of the COVID-19 Pandemic.

This study was performed to evaluate the effectiveness of a hybrid, telephone-based cardiac rehabilitation (tbcr) program implemented early in the covid-19 pandemic compared with in-person, center-based programming offered prior to the pandemic.The focus was on older adults' engagement and outcomes.Matched groups of hybrid and in-person cardiac rehabilitation (cr) participants were created from existing data and compared using t-tests and repeated measures anovas.Qualitative interviews were conducted with participating cr staff then transcribed, coded, and analyzed for key themes.There were significant differences in body mass index and weight from pre-to post-cr within both hybrid and in-person groups.Despite this, cr staff believed exercise adherence was reduced in the hybrid group when compared to those in the in-person program.In the future, tbcr should be considered as an adjunct to in-person cr.Reluctance to prescribe exercise needs to be addressed through cr staff training.

Journal: Journal of applied gerontology : the official journal of the Southern Gerontological Society (2022)
Publication types: Journal Article
Prevalence of Bovine Viral Diarrhea Virus Infections in Pigs on Jeju Island, South Korea, from 2009-2019 and Experimental Infection of Pigs with BVDV Strains Isolated from Cattle.

On jeju island, south korea, pigs have not been vaccinated against classical swine fever (csf) since 1999.Analysis of bovine viral diarrhea virus (bvdv) isolated from pigs on jeju island between 2009 and 2019 identified five bvdv-1a strains and one bvdv-1b strain.These bvdv types were shown to be the same types as bvdv strains isolated from neighboring cow farms.Bvdv antibody-positive pigs (both bvdv-1 and -2) were also detected at 54 of 168 pig farms during this period.In pig infection experiments using bvdv-1a and -2a strains isolated from neighboring cow farms, bvdv-1a was detected in the blood of one of four pigs infected at both 6 and 35 days post-infection (dpi) and in the blood of two of the four pigs at 28 dpi.Pigs showed higher anti-bvdv-1 titers (5.5 ± 1.5 log2) at 35 dpi.Bvdv-2a was detected in the blood of one of four pigs infected with this virus at 28 dpi only, and lower antibody titers (2.75 ± 0.75 log2) were seen in these pigs at 35 dpi.While bvdv infection is not particularly pathogenic in pigs, it is still important to monitor porcine bvdv infections due to a differential diagnosis of csfv.

Journal: Veterinary sciences (2022)
Publication types: Journal Article
Monitoring COVID-19 through SARS-CoV-2 quantification in wastewater: progress, challenges and prospects.

Wastewater-based epidemiology (wbe) is widely used to monitor the progression of the current sars-co v-2 pandemic at local levels.In this review, we address the different approaches to the steps needed for this surveillance: sampling wastewaters (wws), concentrating the virus from the samples and quantifying them by q pcr, focusing on the main limitations of the methodologies used.Factors that can influence sars-co v-2 monitoring in wws include: (i) physical parameters as temperature that can hamper the detection in warm seasons and tropical regions, (ii) sampling methodologies and timetables, being composite samples and moore swabs the less variable and more sensitive approaches, (iii) virus concentration methodologies that need to be feasible and practicable in simpler laboratories and (iv) detection methodologies that should tend to use faster and cost-effective procedures.The efficiency of ww treatments and the use of wws for sars-co v-2 variants detection are also addressed.Furthermore, we discuss the need for the development of common standardized protocols, although these must be versatile enough to comprise variations among target communities.Wbe screening of risk populations will allow for the prediction of future outbreaks, thus alerting authorities to implement early action measurements.

Journal: Microbial biotechnology (2022)
Publication types: Journal Article;Review
The first isolation and detection ofOrnithobacterium rhinotrachealefrom swollen head syndrome-infected broiler flocks in Iraq.

And aim the swollen head syndrome (shs) makes up complex diseases that infect the upper respiratory tract in poultry and causes several economic losses.Furthermore, this syndrome is considered one of the multifactorial etiological agents.Therefore, this study isolated and molecularly detected ornithobacterium rhinotracheale(ort) in poultry.Materials and methods this study was conducted at 67 broiler farms that had birds observed to be infected with the shs from september 2018 until august 2019.Subsequently, swabs were collected from their trachea, infraorbital sinuses, and lungs, after which obtained samples were treated through two methods: (a) the direct method, by uploading samples on fta cards, and the indirect method using a transport media.Afterward, reverse transcription-polymerase chain reaction (rt-pcr) was used to analyze the directly treated samples; however aq1, the culture method, followed by pcr, was used to analyze the indirectly treated samples.Next, a partial16s rnagene was isolated using four positive pcr products, after which the effect of 16 antibiotics was studied on the seven local ort strains isolated.Results the quantity of ort isolated using the direct method was 28 (41.7%) samples, which were all positive for the strain.Identification was by direct molecular identification (rt-pcr) from samples loaded on fta cards.Alternatively, 7 (10.4%) orts were detected from the indirect method, as obtained using the culture method and biochemical tests.Then, pcr was subsequently used to confirm the results.As observed, 784 bp bands were shown for all seven ort isolates.Furthermore, results revealed a significant difference in the detection of ort strains between direct and indirect methods, with p-value (<0.05) and standard deviation of the error±0.038 for the direct, then ±0.061 for the indirect method.For further analysis on the strain types, four 784 bp pcr products were taken, then partial 16s ribosomal sequence typing was conducted.All these four strains were found to be recorded in ncbi for the 1sttime as a local iraqi strain, with accession numbers (mn931657, mn931656, mn931655, and mn931654).Notably, results also showed that all isolated strains were multidrug-resistant.Conclusion from the results, ort is proposed to be implicated as one of the etiological factors that cause shss in poultry.Phylogenetic analysis of the current ort bacterial strains also showed that they are closely related to the egyptian isolates.

Journal: Veterinary world (2021)
Publication types: Journal Article
A rational design and green synthesis of 3D metal organic frameworks containing a rigid heterocyclic nitrogen-rich dicarboxylate: structural diversity, CO2sorption and selective sensing of 2,4,6-TNP in water.

A heterocyclic fluorogenic linker, thiadiazole dicarboxylate (h2tdz), offering diverse coordination modes has been utilized to synthesize two three-dimensional (3d) metal organic frameworks {[cd2(tdz)2(4,4'-bpy)2]·6.5h2o}n (1) and [cu(tdz)(4,4'-bpy)]n (2) from a one-pot self-assembly reaction under ambient conditions in high yields.Mofs 1 and 2 are structurally characterized by elemental analysis, ftir and uv-vis spectroscopy, single crystal and powder x-ray diffraction, and thermogravimetric analysis.Their single crystal molecular structures reveal that 1 contains a permanent pore along the b-axis with dimensions of 14.576 × 17.567 å2 while 2 forms a 3d two-fold interpenetrated structure with an extensively reduced pore size.The effect of interpenetration has been further elaborated by a comparison of their co2 uptake capacities at 263 k, 273 k and 298 k.The uptake value of co2 for non-interpenetrated 1 (24.8 cm3 g-1) is much higher compared to that of interpenetrated 2 (5 cm3 g-1) at 298 k.Furthermore, to obtain an insight into the adsorbate-adsorbent interaction owing to the presence of the polar thiadiazole moiety and polarizable co2 molecules, the isosteric heat of adsorption (qst) was calculated for 1 (29.1 k j mol-1) and 2 (23.4 k j mol-1).Thermal and chemical stabilities of 1 in water were ascertained by variable temperature powder x-ray diffraction (vt-pxrd) analysis.Mof 1 having a d10 metal center was utilized to harness the availability of nitrogen atoms in the tdz2- linker for the selective sensing of nitrophenols in water with a detection limit for tnp as low as 1.4 ppm.Moreover, 1 is found to be stable and recyclable up to four cycles.

Journal: Dalton transactions (Cambridge, England : 2003) (2019)
Publication types: Journal Article
Impacts of using orthodontic appliances on the quality of life of children and adolescents: systematic review and meta-analysis.

Although there are previous systematic reviews about the oral health-related quality of life (ohrqo l) impact among children and adolescents after orthodontics treatment, there is no definition for the magnitude of these impacts during the therapy.Objective to systematically analyse the literature on changes in the quality of life of children and adolescents during orthodontic treatment.Limitations almost all the studies included in this review are non-randomized clinical trials, which are susceptible to several biases that affect the certainty of evidence obtained, especially by confounding factors and the lack of a control group.Conclusions and implications based on very low certainty of evidence, wearing appliances does not seem to have a significant negative impact during the first year of orthodontic treatment.However, the meta-analytic results suggest that functional limitations in the first 3 months of treatment can be slightly more critical for the impact on the oral health quality of life and consequent patient adherence to treatment.Funding this study was financed by the coordenação de aperfeiçoamento de pessoal de nível superior - brazil (capes), conselho nacional de desenvolvimento científico e tecnológico - brazil (cnpq), and fundação de amparo à pesquisa do estado de minas gerais - brazil (fapemig).Registration crd42021234407.

Journal: European journal of orthodontics (2022)
Publication types: Journal Article;Meta-Analysis;Systematic Review;Research Support, Non-U.S. Gov't
Early Exposure to Animals and Childhood Body Mass Index Percentile and Percentage Fat Mass.

Introduction a few studies have identified childhood animal exposure as associated with adiposity, but results are inconsistent and differ in timing.Methods we conducted an observational cohort study of children ages 4-8 in the environmental influences on child health outcomes [echo] study.The main exposure was having a dog in the home and/or regular contact with farm animals during the first year of life.Outcomes of interest were child bmi percentile (adjusted for gender and age) categorized as normal/underweight (<85thpercentile), overweight (85thto <95th), and obese (≥95th), and percent fat mass (continuous).Associations were analyzed using multinomial logistic regression and multivariable linear regression, respectively, with and without multiple imputation.Results first year animal exposure occurred in 245 of 770 (31.8%) children.Children with early animal exposure had 0.53 (95% ci: 0.28, 0.997) times the odds of being in the obese bmi category compared to those exposed to animals after controlling for covariates: maternal pre-pregnancy bmi, race/ethnicity, reported child activity level, receiving food assistance, age child began daycare (<1 year vs 1+), exclusively breastfed x6 months, and nicu admission (n=721).Children with early animal exposure had, on average, 1.5% (95% ci: -3.0, -0.1) less fat mass than exposed children after adjustment for maternal bmi, race/ethnicity, activity, food assistance, breastfeeding, and maternal education (n=548).Multiple imputation did not alter either result.Conclusion these results provide evidence that exposure to dogs or farm animals in the first year of life is associated with lower odds of obesity and lower percent fat mass in childhood.

Journal: Child and adolescent obesity (Abingdon, England) (2022)
Publication types: Journal Article
Invasive ductal carcinoma mammographic findings: Correlation with age, breast composition and tumor size.

/objective the aim of this study was to identify the mammographic findings associated with malignancy in different age groups, taking into account breast composition (bc) and lesion size.Methods preoperative mammograms of 1023 invasive ductal carcinomas were retrospectively evaluated.According to the american college of radiology breast imaging reporting and data system, cancer mammographic findings were classified as mass, calcifications, architectural distortion and asymmetry, and breasts were assessed as non-dense (a or b bc) and dense (c or d bc).Patient cohort was subdivided into three age groups (group 1: <50 years of age; group 2: between 50 and 69; group 3: ≥70 years of age).Results significant results of multinomial logistic regression were the association between mass and non-dense breast (p < 0.0001) and the association between mass and tumor size larger than 15 mm (p = 0.0049).Conclusions mass finding of invasive ductal breast carcinoma is associated with breast composition and tumor size.

Journal: Breast disease (2022)
Publication types: Journal Article
Corneal Endothelial Cell Loss after Ciliary Sulcus Placement of Ahmed Glaucoma Valve in Patients with Noninfectious Uveitic Glaucoma.

This study was performed to investigate the corneal endothelial cell density (cecd) reduction and treatment efficacy in patients with uveitic glaucoma treated by the ciliary sulcus placement of the ahmed glaucoma valve (agv).This retrospective study included 27 eyes of 27 patients with noninfectious uveitis who underwent the sulcus placement of the agv.Each patient underwent a clinical assessment including a cecd measurement before surgery and at 3, 6, 9, and 12 months after surgery.The mean cecd was 2431.4 ± 367.5 cells/mm2 at preoperative baseline and 2360.5 ± 391.3 cells/mm2 at 12 months (p = 0.074), with a reduction rate of 2.73 ± 9.29%.The cecd reduction was significantly greater in patients with unilateral uveitis than that with bilateral uveitis.The rate of successful intraocular pressure control was 88% at 12 months, and the number of intraocular pressure-lowering medications was significantly reduced (p < 0.001).The current study showed that the implantation of an ahmed tube into the ciliary sulcus provided stable intraocular pressure control in patients with glaucoma secondary to noninfectious uveitis, and cecd reduction was moderate in most patients at 12 months.

Journal: Journal of personalized medicine (2022)
Publication types: Journal Article
Sex-based differences in outcomes for adult patients presenting to the emergency department with a concussion.

Patients with concussion frequently present to the emergency department (ed).Studies of athletes and children indicate that concussion symptoms are often more severe and prolonged in females compared with males.Given infrequent study of concussion symptoms in the general adult population, the authors conducted a sex-based comparison of patients with concussion.Methods adults (≥ 17 years of age) presenting with concussion to one of three urban canadian eds were recruited.Discharged patients were contacted by telephone 30 and 90 days later to capture the extent of persistent postconcussion symptoms using the rivermead post concussion symptoms questionnaire (rpq).A multivariate logistic regression model for persistent symptoms that included biological sex was developed.Results overall, 250 patients were included; 131 (52%) were women, and the median age of women was significantly higher than that of men (40 vs 32 years).Women had higher rpq scores at baseline (p < 0.001) and the 30-day follow-up (p = 0.001); this difference resolved by 90 days.The multivariate logistic regression identified that women, patients having a history of sleep disorder, and those presenting to the ed with concussions after a motor vehicle collision were more likely to experience persistent symptoms.Conclusions in a community concussion sample, inconsequential demographic differences existed between adult women and men on ed presentation.Based on self-reported and objective outcomes, work and daily activities may be more affected by concussion and persistent postconcussion symptoms for women than men.Further analysis of these differences is required to identify different treatment options and ensure adequate care and management of injury.

Journal: Journal of neurosurgery (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Twin Reversed Arterial Perfusion.

Twin reversed arterial perfusion (trap) sequence is a rare condition found only in monochorionic pregnancies.It is a sequence in which a severely anomalous twin with an absent or rudimentary heart, also called an "acardiac twin," is perfused by its co-twin.The cardiac system of this co-twin (pump twin) provides circulatory support to the acardiac twin from as early as the first trimester.The exact pathogenesis of trap sequence is still unknown.However, the mere presence of vascular anastomoses in the placenta alone cannot lead to the development of trap sequence.Moreover, the presence of retrograde blood flow through arterio-arterial anastomoses increases the possibility of trap sequence diagnosis in a suspected monochorionic twin pregnancy.This report presents a case of trap sequence, which was undiagnosed till the delivery of twins.A 26-year-old patient gravida 3 para 2 (g3p2+0) with previous two normal deliveries, was referred to our emergency labor room at (assumed) 37 weeks of pregnancy, from a primary health center with complaints of vaginal leakage and a non-reassuring fetal status.She was immediately shifted to operation theatre and an emergency lower-segment cesarean section was performed.At the time of delivery, she was diagnosed as having a monochorionic diamniotic twin with trap sequence as one of the twins was acardiac, while the other was a live male baby (the pump twin) with massive ascites.A trap sequence pregnancy with a poor prognostic factor requires twin cord occlusion therapy or another form of intervention.Termination of the pregnancy is also an option, as it saves the patient from unnecessary obstetrical complications and morbidity.

Journal: Cureus (2022)
Publication types: Case Reports;Journal Article
Identification of novel natural inhibitors targeting AKT Serine/Threonine Kinase 1 (AKT1) by computational study.

Despite great progress, the current cancer treatments often have obvious toxicity and side effects.And a poor prognosis (some patients).One of the reasons for the poor prognosis is that certain enzymes prevent anticancer drugs from killing tumor cells.Akt1 is involved in regulating pi3k/akt/m tor, a tumor-generating pathway.Ipatasertib, a highly selective inhibitor of akt1, is widely used in the treatment of tumors.In this study, many structural and biochemical methodswere used to find better akt1(threonine kinase 1) inhibitors, which laid a foundation for the further development of akt1 inhibitors and provided new drugs for the treatment of tumors.Zinc15 database and discovery studio 4.5, a computer-aided drug screening software with many modules (lib dock for virtual screening, adme (absorption, distribution, metabolism, excretion) and topkat (toxicity prediction module) for the toxicity and properties analysis, and md simulation for stability prediction), were employed.Cck8 assay, elisa assay genicity and higher tolerance to cytochrome p4502d6.Md simulations indicated they could bind with akt1 stably in the natural environment.The cell experiment and specific assay for akt1 inhibition showed they could inhibit the proliferation and akt1 expression of mg63 cells (osteosarcoma cells).Moreover, these novel compounds with structural modifications can be potential contributors that lead to further rational drug design for targeting akt1.abbreviation akt1, akt serine/threonine kinase 1; adme, absorption, distribution, metabolism, excretion; topkat, toxicity prediction by computer assisted technology; cck8, cell counting kit 8; elisa, enzyme-linked immunosorbent assay; cyp2d6, cytochrome p4502d6 inhibition; gbm, glioblastoma; agc kinase, protein kinase a, g, and c families (pka, pkc, pkg); pkb, protein kinase b; pam pathway, pi3k/akt/m tor pathway; os, overall survival; pfs, progression-free survival; ld50, lethal dose half in rats; loael, lowest observed adverse effect level; npt, normal pressure and temperature; pme, particle mesh ewald; lincs, linear constraint solver; rmsd, root-mean-square deviation; bbb, blood-brain barrier; ds, discovery studio; dtp, developmental toxicity potential; ppb, plasma protein binding; mtd, maximum tolerated dosage; ab, aerobic biodegradability; ntp, us.National toxicology program; dtp, developmental toxicity potential.

Journal: Bioengineered (2022)
Publication types: Journal Article