syedzayyan/paper_mill_benchmark huggingface dataset:
Therapeutic Effect of Tendon Bone Setting Technique and Sports Training on Joint Injury

In this study, we observe the therapeutic influence on tendon and bone setting technique, combined with sports training on joint injury.Methods.Using the random number method, 50 research objects with joint injuries were divided into two groups: treatment group and control group, and each group had 25 cases.The treatment group was combined with sports training with tendon and bone setting technique, and the control group was given intermediate frequency electrotherapy combined with forearm brace fixation.The scores of visual analogue scale (vas), forearm pronation and postrotation activity, integral electromyogram (i emg), and research object-rated wrist evaluation (prwe) were evaluated and compared before and after treatment, and the curative effect observation (blind method was used in the evaluation process) and research object satisfaction were evaluated.Results.After the treatment, the vas score of two groups decreased, forearm pronation and pronation activity increased, i emg value increased, and prwe scale score decreased ( p &lt; 0.05), and compared with the control group, the treatment group’s curative effect was better ( p &lt; 0.05), and compared with the control group, treatment group’s total effective rate was higher ( p &lt; 0.05).Conclusion.The method of tendon and bone setting combined with sports training could effectively reduce the pain of research objects with joint injury, improve the rotation range of the forearm, increase the recruitment of the pronator muscles, and improve the wrist function of the research objects, and the curative effect was better than that of medium frequency electrotherapy combined with forearm brace fixation.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Clinical Study;
Traditional Chinese Medicine Moxibustion in the Treatment of Infantile Diarrhea

The main contribution of this research paper is to summarize the results of meta-analysis of moxibustion in the treatment of infantile diarrhea which is one the common disease and requires considerable attention from the research community and funding organizations.In order to verify that the proposed scheme has merits, a comprehensive searching methodology was adopted by considering various databases such as china biomedical literature database (cbm), china national knowledge network infrastructure (cnki), wanfang database, pub med database, google academic, and cochrane library.It is important to note that a powerful computer has been utilized to carry out this searching.Finally, only those literature contents are selected which meet the inclusion criteria.Likewise, exclusion criteria was used to exclude irrelevant contents of the literature.Rev man 5.3 was used to analyze the collected data and after reading the titles and abstracts, 29 well-designed studies were selected.Through searching the full text, reading literature, and quality evaluation, 17 papers were finally included.Response rates were reported in all 17 studies, and subgroup analysis was performed based on whether or not other therapies were combined.7 studies compared the effectiveness of simple moxibustion and conventional therapy in the treatment of infantile diarrhea, and the results showed statistically significant differences [or = 4.01, 95% ci (2.03, 7.84), p &lt; 0.0001 ]; 10 studies compared the effectiveness of moxibustion combined with other therapies and conventional therapies in the treatment of diarrhea in children, and the results showed that the difference had general meaning [or = 4.45, 95% ci (2.83, 7.10), p &lt; 0.00001 ].The funnel plot (in figure) showed that the distribution of included studies was asymmetrical on both sides of the baseline, which could be considered as publication bias.Traditional chinese medicine moxibustion could effectively relieve the symptoms of infantile diarrhea, and the effect was significant.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Meta-Analysis;
The Therapeutic Potential of Wogonin Observed in Preclinical Studies

Wogonin is a flavonoid found in different plants such as roots of scutellaria baicalensis georgi distributed mainly in asia and europe.Dried root extracts of s.Baicalensis with high content of wogonin, popularly known as “huang-qin” or chinese or baical skullcap, have been used for long time in traditional chinese medicine.Several health benefits are attributed to wogonin and derivatives showing anti-inflammatory, antiviral, anticancer, and antioxidant effects and more recently antineurodegenerative properties.Preclinical pharmacological activities of wogonin against diverse types of cancer such as breast, colorectal, and human gastric cancer will be presented in this review.In addition, studies on oxidative stress and bioavailability of wogonin will be discussed together with antineurodegenerative potential with special focus on alzheimer’s disease.Outcomes extracted from the last preclinical studies related to therapeutic applications of wogonin will be commented and updated in this review.The scientific evidence collected in this review aims to encourage transfer of the preclinical evidence of wogonin to new clinical studies.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Review Article;
Relationship between Severity of Lumbar Spinal Stenosis and Ligamentum Flavum Hypertrophy and Serum Inflammatory Factors

This study is aimed at investigating the correlation between lumbar spinal stenosis (lss) severity, ligamentum flavum hypertrophy, and the upregulation of inflammatory markers.Methods.From march 2019 and may 2022, eighty-five inpatients with lss were enlisted as the study’s research group, while sixty-five patients hospitalized for lumbar intervertebral disc herniation over the same time period served as the study’s control group.Moreover, mild, moderate, and severe subgroups of patients were created within the research population based on their lss severity.The ligamentum flavum thickness and the positive expression rates of tnf-α, tgf-β1, and il-1α were compared between the study group and the control group.The levels of tnf-α, tgf-β1, and il-1α that were found to be positively expressed were compared between the mild, moderate, and severe groups.Patients with lss had their ligamentum flavum thickness and their positive expression rates of tnf-α, tgf-β1, and il-1α analyzed using spearman correlation analysis.We evaluated the diagnostic utility of the positive expression rates of il-α1, tgf-β1, and tnf-α and ligamentum flavum thickness in distinguishing the severity of lss using a receiver operating characteristic (roc) curve.Results.The rates of both lower limb pain (40.00%) and intermittent claudication (80.00%) in the lss group were higher than those in the lumbar disc herniation group (15.38%, 12.31%), with statistical significance ( p &lt; 0.05 ).However, no substantial disparity was observed in left lower limb pain, right lower limb pain, low back pain, lower limb sensation, muscle strength, and reflex abnormalities between the two groups ( p &gt; 0.05 ).Positive expressions of tgf-β1, tnf-α, and il-1α and thicker ligamentum flavum were more prevalent in the lss group than in the lumbar intervertebral disc herniation group.All indexes were significantly ( p &lt; 0.05 ) higher in the moderate stenosis group than in the severe stenosis group.Additionally, the thickness of the ligamentum flavum and the positive expression rates of tnf-α, tgf-β1, and il-1α were higher in the mild and moderate stenosis groups than in the severe stenosis group.The expression levels of tnf-α, tgf-β1, and il-1α were favorably linked with ligamentum flavum thickness ( p &lt; 0.05 ).Roc curve analysis showed that the thickness of ligamentum flavum, the expression of il-1α, the expression of tgf-β1, and the expression of tnf-α could effectively diagnose mild, moderate, and severe lss ( p &lt; 0.05 ).Conclusion.Ligamentum flavum hypertrophy and positive expression rates of il-1α, tgf-β1, and tnf-α are closely linked to lss, which can effectively identify mild, moderate, and severe lss.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Regulation of Apelin-13 on Bcl-2 and Caspase-3 and Its Effects on Adipocyte Apoptosis

The effects of apelin-13 on the expression of bcl-2 and caspase-3 factors and the apoptosis of adipocytes were studied at the cellular and animal levels.Methods.3t3-l1 preadipocytes were cultured and grouped.The third-generation cells were added to the control dmso solvent and amidation-modified apelin-13.The expression of bcl-2 and caspase-3 were detected.The cell growth viability and cell apoptosis were detected.Doi model rats were established.The effects of apelin-13 on doi rat biochemical indicators, the expression of bcl-2, caspase-3, and cell apoptosis were investigated by injecting amidation-modified apelin-13 through the tail vein.Result.In in vitro experiments, amidation-modified apelin-13 can significantly reduce the growth viability of adipocytes and the expression of bcl-2, increase the expression of caspase-3, and promote the apoptosis of adipocytes.Animal experiments also show that apelin-13 modified by amidation can adjust the abnormal biochemical indicators of doi rats, decrease the expression of bcl-2 in adipose tissue, increase the expression of caspase-3, and promote the apoptosis of adipocytes.Conclusion.Amidation of apelin-13 can promote fat cell apoptosis and reduce the incidence of obesity.The mechanism may be accomplished by inhibiting bcl-2 and caspase-3 factors.This study helps us understand the effect of apelin-13 on fat cell apoptosis and hopes to provide a basis for the development of antiobesity drugs.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Research Article;
Random Forest Algorithm-Based Ultrasonic Image in the Diagnosis of Patients with Dry Eye Syndrome and Its Relationship with Tear Osmotic Pressure

The study was to investigate the diagnostic value of ultrasound based on the random forest segmentation algorithm for dry eye disease and the relationship between dry eye degree and tear osmotic pressure.Specifically, 100 patients with dry eye syndrome were selected as the research subjects, and they were divided into group a (conventional ultrasonic detection) and group b (ultrasonic detection based on the random forest segmentation algorithm), with 50 patients in each group.An ultrasonic measurement was used as the gold standard to evaluate the effect of ultrasonic diagnosis.The degree of dry eye was determined by ocular surface disease index (osdi) questionnaire and dr-1 tear film lipid layer (tfll) test.The tear osmotic pressure was measured, and the relationship between the degree of dry eye disease and the tear osmotic pressure was analyzed.The results showed that the ultrasonic imaging effect and each index based on random forest algorithm were better than the traditional graph cut algorithm.The average central corneal thickness (cct) values of group a and group b were ( 27.8 ± 30.6 ) μm and ( 29.1 ± 30.9 ) μm, respectively.95% confidence interval was 22.7-34.2 μm.In patients with moderate dry eye, the average cct measured in group a was ( − 6.31 ± 2.82 ) μm, and that in group b was ( − 6.45 ± 3.06 ) μm.The 95% confidence interval of the difference between the two is −7.66~−5.43 μm.In patients with severe dry eye, the average cct was ( − 3.78 ± 1.13 ) μm in group a and ( − 7.09 ± 2.05 ) μm in group b ( p &lt; 0.05 ).The 95% confidence interval of the difference between the two is −7.05~ −5.11 μm.In spearman correlation analysis, tear osmotic pressure increased with dry eye severity.There was a statistically significant difference between the moderate and the severe ( p &lt; 0.05 ).Tear osmotic pressure can be a rapid diagnostic index of dry eye severity.Ultrasound based on the random forest segmentation algorithm has high clinical application value in the diagnosis of dry eye syndrome.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Protective Effect of Targeted Fluid Therapy on Patients with One-Lung Ventilation

To evaluate the protective effect of target-directed fluid therapy on the lungs and postoperative rehabilitation in elderly patients with single-lung ventilation undergoing total endoscopic radical resection of esophageal cancer.Methods.Seventy elderly patients who underwent total endoscopic radical resection of esophageal cancer from january 2017 to december 2019 in our hospital were selected and divided into two groups by the random number table method: the goal-directed fluid treatment group (group g, n = 35) and the control group (group c, n = 35).Venous blood was extracted before surgery (t1), at the end of free esophagus (t2) by thoracoscopy, at the end of abdominal surgery (t3), and at the end of surgery (t4).Il-6 and il-10 levels were detected by elisa.The clinical pulmonary infection score (cips) was used to evaluate the pulmonary inflammation on the second day after surgery and the occurrence of complications.Duration of antibiotic use and length of hospital stay were recorded.Results.At t1, there were no significant differences in il-6 and il-10 levels between the two groups ( p &gt; 0.05 ).At t2, the il-6 level in group g increased to 26.65 ± 1.80 pg/ml but was significantly lower than that in group c (32.28 ± 3.22 pg/ml) ( p &lt; 0.01 ).At t3 and t4, il-6 and il-10 levels in group g were significantly lower than those in group c ( p &lt; 0.01 ).The cips score of group g was lower than that of group c (1.5 ± 1.0 vs 2.7 ± 1.4), and the duration of antibiotic use in group g was shorter than that in group c (211.2 ± 15.4 vs 232.6 ± 18.7 h), with statistical significance ( p &lt; 0.01 ).The incidence of complications in group g was lower than that in group c (28.6% vs 40.0%), and the length of hospital stay in group g was shorter than that in group c (10.5 ± 1.7 vs 11.2 ± 1.9 days), but there was no significant difference between the two groups ( p &gt; 0.05 ).Conclusion.Target-directed fluid therapy inhibited inflammatory cytokine levels and had better lung protection, but no significant benefit in the complications or the length of hospital stay was observed.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Preparation of Curcumin Solid Lipid Nanoparticles Loaded with Flower-Shaped Lactose for Lung Inhalation and Preliminary Evaluation of Cytotoxicity In Vitro

The purpose of this study is to design a flower-shaped lactose loaded curcumin solid lipid nanoparticles dry powder inhaler and characterize it to improve the solubility and dissolution rate of curcumin in lung.Curcumin solid lipid nanoparticles (cur-slns) were prepared by solvent evaporation method, and then they were micronized by freeze-drying technology.Finally, cur-sln micropowder obtained by freeze-drying was mixed with flower-shaped lactose (fl) at a ratio of 2 : 1 and then passed through a 200-mesh sieve to obtain cur-sln-fl powder.Tween-80 was selected as the surfactant to inhibit the aggregation of drug solid lipid nanoparticles.Under the optimum conditions, the solid lipid nanoparticles (sln) were relatively spherical, with an average particle size of 14.7 nm, narrow distribution, zeta potential of −22.5 m v, encapsulation efficiency of 90.21%, and drug loading of 8.56%.According to the particle size, pi, zeta potential, drug loading (lc%), encapsulation efficiency (ee%), morphology, and in vitro release characteristics, the prescription of solid lipid nanoparticles was screened.Dry powder inhaler (dpi) was characterized by differential scanning calorimetry, scanning electron microscopy, particle size, density, and in vitro release performance.Its cytotoxicity to mouse fibroblasts (l929) and human normal lung epithelial cells (beas-2b) in vitro was investigated, and its safety for pulmonary inhalation was preliminarily determined.Ftir analysis shows that the micronized cur-sln-fl has the same chemical structure as fl.Ftir and dsc analysis confirmed that the characteristic absorption peak of curcumin was not found in cur-sln-fl, showing similar structure to sln and fl.In addition, curcumin was coated in solid lipid nanoparticles to make powder mist, which increased its drug loading, kept its aerodynamic particle size (4.03 ± 0.40) μm, and significantly improved its drug release performance in artificial lung fluid.In vitro cytotoxicity test results confirmed that cur-sln-fl was less toxic to beas-2b cells than l929 cells.Therefore, curcumin was prepared into solid lipid nanoparticles by emulsion evaporation-low temperature solidification method and then micronized and mixed with fl to prepare curcumin solid lipid nanoparticle powder mist loaded with flower-shaped lactose.The process is simple and feasible, and it has better safety performance for lung cells, which is expected to become a safe and effective delivery system for pulmonary inhalation drugs.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Research Article;
Preoperative 3D Reconstruction Model in Slow Mohs Surgery for Dermatofibrosarcoma Protuberans

Dermatofibrosarcoma protuberans (dfsp) is a type of skin cancer that is extremely rare.Its standard treatment is either surgical wide-local excision (wle) or mohs micrographic surgery (mms).Which method has the lowest recurrence rate is unknown.Dermatofibrosarcoma protuberans is an uncommon soft tissue sarcoma with a high propensity for recurrence.It has always remained a clinical challenge.More technology is needed to treat the disease.We reviewed our cases and published experience and evaluated whether 3d modeling could precisely define tumor morphological characteristics and assist excision in slow mohs surgery.There were 18 dermatofibrosarcoma protuberan cases enrolled.They were treated in shanghai ninth people’s hospital from 2014 to 2019.All the 18 included patients presented with primary disease and no metastasis.All subjects had undergone thorough imaging examinations including ct and mri.The 3d tumor reconstruction models were created for their tumors.We precisely estimated tumor boundaries and sizes according to those 3d models.Afterward, patients underwent slow mohs surgery and surgical repair of tissue defects following tumor resection.The 3d tumor reconstruction models were successfully established.The predicted tumor volumes were measured in all 18 cases.The average volume was 38.5 cm3 (range: 8.4 cm3–183.6 cm3), which allowed for accurately locating the tumor.Tumors were completely removed in one stage of slow mms surgery.In the second-stage surgery, the defects were repaired by different surgical methods including direct soft tissue closure, skin grafting, local flaps, or free flaps.Most patients experienced no significant complications.This practice indicated that the combination of a 3d reconstruction model and slow mohs surgery achieves more precise and complete dfsp resection to decrease the recurrence rate.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Review Article;
Predictive Value of Apelin and Vaspin on Hemorrhagic Transformation in Patients with Acute Ischemic Stroke after Intravenous Thrombolysis and Analysis of Related Factors

Acute ischemic stroke (cis) is a high-risk condition among the elderly, and intravenous thrombolytic therapy (itt) is the most effective means for it.However, itt is prone to induce hemorrhagic transformation (ht) that further threatens the life and health of patients.As paramount substances in cardiovascular and cerebrovascular diseases, adipocyte factor (apelin) and serine protease inhibitor (vaspin) are strongly bound up with cis.Objective.To analyze the predictive significance of apelin and vaspin on ht in cis patients after itt and offer effective reference to ht prevention in the future.Methods.A total of 109 cis patients treated with intravenous thrombolysis (it) in two hospitals between june 2017 and february 2018 were enrolled.Among them, 48 patients who suffered ht after therapy were assigned to the research group (res group) and the other 61 patients who did not suffer it after therapy were assigned to the control group (con group).Serum apelin, vaspin, inflammatory factors, and oxidative stress levels were quantified, and receiver operating characteristic (roc) curves were drawn for analyzing the predictive value of apelin and vaspin on ht after itt and their associations with inflammatory factors and oxidative stress.Cis patients who suffered ht were followed up for 3 years for prognostic significance analysis of apelin and vaspin.Results.After itt, the res group showed lower apelin and vaspin levels than the con group (all p &lt; 0.05 ), and patients with a higher ht grade had lower apelin and vaspin levels (all p &lt; 0.05 ).The joint detection of apelin and vaspin showed a sensitivity of 77.08% and a specificity of 73.77% for forecasting ht in cis patients after thrombolytic therapy (all p &lt; 0.001 ).In addition, after thrombolytic therapy, the res group presented higher levels of interleukin-1β (il-1β) and il-6 as well as malondialdehyde (mda) than the con group, and the levels had negative associations with apelin and vaspin (all p &lt; 0.05 ).The res group showed a lower superoxide dismutase (sod) level than the con group, and the level presented a positive association with apelin and vaspin (all p &lt; 0.05 ).According to logistic analysis, il-1β, il-6, and mda were independent risk factors for ht in cis patients after it, while apelin, vaspin, and sod were independent protective factors (all p &lt; 0.05 ).According to the follow-up results, apelin and vaspin demonstrated excellent value in forecasting the death of patients with both cis and ht ( p &lt; 0.05 ), and their lower levels indicate a higher risk of death (all p &lt; 0.05 ).Conclusion.Apelin and vaspin can help effectively forecast the occurrence of ht in cis patients after itt as independent protective factors of ht, so they are of a high clinical application value.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Clinical Study;