syedzayyan/paper_mill_benchmark huggingface dataset:
Analysis of the Effect of Cluster Nursing in Postoperative Hypertensive Cerebral Hemorrhage

Hypertensive intracerebral hemorrhage is a common condition in clinic.Due to the improvement of minimally invasive technology, its therapeutic effect is good, but there are still postoperative complications.The corresponding routine nursing intervention is not effective in the rehabilitation of postoperative patients with hypertensive intracerebral hemorrhage.In this paper, cluster nursing was applied to the treatment of postoperative patients with hypertensive intracerebral hemorrhage.For this purpose, a retrospective study or experiment was conducted on 150 patients with hypertensive intracerebral hemorrhage in the hospital specifically from january 2019 to december 2020.According to the nursing strategy, patients were divided into experimental (n = 75) and control groups (n = 75), respectively.The control group adopted routine nursing mode, whereas the experimental group adopted cluster nursing mode.The treatment compliance of patients in the experimental group was 86.67%, while that in the control group was 73.33% ( p &lt; 0.05).The total incidence of postoperative complications in the experimental group was 3.2%, which was lower than 25% in the control group ( p &lt; 0.05).The motor function score of the experimental group was better than that of the control group ( p &lt; 0.05).The application of cluster nursing in postoperative patients with hypertensive intracerebral hemorrhage is feasible, and its nursing effect is significant, which can not only reduce the incidence of postoperative complications but also improve patients’ compliance and quality of life.It has good application value.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Analysis of the Diagnostic Effect of EUS-RTE on Giant Cystic Tumours of the Oesophagus Based on Cluster Analysis

This paper presents an in-depth analysis and study of the diagnostic effectiveness of eus-rte in giant cystic tumours of the oesophagus utilizing cluster analysis.A new form of interval data expression was designed based on the cluster analysis algorithm, as well as a new way of updating the cluster radius and cluster centre.Feature triads are defined, eliminating the need to access all historical data at the time of update.It also prevents the case of overfusion of clusters and outputting only one cluster.If there exist a very low number of clusters, the newly merged clusters are reclustered according to the density clustering method for the internal data objects based on the cluster segmentation so that the data objects in the same cluster have a high similarity as possible.All accumulated electronic files of oesophageal cancer cases were collected and comprehensively organized, and all clinical data of 129 eligible cases with a total of 356 consultations were screened in strict accordance with inclusion and exclusion criteria.A database of oesophageal cancer cases was established using visual fox pro software, and frequency distribution, cluster analysis, association rule, and chi-square test were used to focus on mining the association between symptoms, disease mechanisms, prescriptions, and medications.The results were analysed and summarized.Overall, the therapeutic efficacy and safety of the three groups of treatment modalities for gastric mesenchymal tumours were positive, and the preoperative endoscopic treatment modalities should be selected based on the eus-rte characteristics of the tumour, the site, and the operator’s skill level in a comprehensive manner.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Analysis of the Clinical Effect of Visual Electrophysiological Examination Combined with Targeted Health Education Nursing in Children

To analyze the clinical effect of visual electrophysiological examination combined with targeted health education nursing in children.Methods .A total of 100 children who underwent visual electrophysiological examinations in the ophthalmology department of our hospital from march 2019 to march 2021 were selected as the study subjects.The children were randomly divided into two groups, the control group and the observation group, with 50 children in each group.Children in the control group received routine nursing, while those in the observation group received a combination of routine nursing and targeted health education nursing.The nursing satisfaction, degree of cooperation with examination, examination time, changes in the psychological state, and the stress response of the children and their families were then compared and analyzed.Results.The nursing satisfaction of the observation group was higher than that of the control group (94.0% vs.80.0%) ( p &lt; 0.05).The degree to which children in the observation group cooperated with examination was higher than that of children in the control group (96.0% vs.78.0%) ( p &lt; 0.05).The average time spent on vep and erg examinations by children in the observation group was 6.33 ± 1.37 hours and 55.25 ± 4.92 hours, respectively, significantly lower than that of 12.45 ± 1.02 hours and 70.36 ± 5.31 hours, respectively, spent by children in the control group ( p &lt; 0.05).After intervention, the depression, hostility, anxiety, and obsession scores of children in the observation group were all significantly lower than those of children in the control group ( p &lt; 0.05).There was an increase in the heart rate, respiratory rate, and mean arterial pressure in children from both groups, but the magnitude of increase in the observation group was much smaller than that in the control group ( p &lt; 0.05).Conclusion .The combination of visual electrophysiological examination and targeted health education nursing in children has a remarkable clinical effect.It improves the children’s degree of comfort as well as the parents’ degree of satisfaction.It also reduces the time spent on examinations, facilitates the smooth completion of examinations, and improves the efficiency of examinations.This nursing method is one that merits more widespread promotion and clinical application.

Journal: Evidence-Based Complementary and Alternative Medicine (2023)
Publication types: Research Article;
Analysis of Risk Factors and Protective Strategies for Tube Blockage in Patients with Drug-Induced Liver Failure Based on Artificial Liver Therapy

To analyse the influencing factors of tube blockage during the treatment of artificial liver in patients with drug‐induced liver failure and explore effective patient protection strategies.Methods .In this study, 49 patients with pharmacological (antituberculosis drugs, antibiotics, proprietary chinese medicine, gastric drugs, and antihyperthyroid drugs) liver failure admitted to our hospital from june 2015 to december 2021 were selected for prospective analysis.Clinical indicators and general data of all patients were collected and collated, risk factors leading to the obstruction of artificial liver treatment were analysed, and corresponding protective measures were proposed.Results .The incidence of tube blockage was 5.32% (10 times) in 49 patients with pharmacological liver failure treated 188 times with artificial liver therapy.The incidence of tube blockage was significantly higher in patients in the pdf mode than in those in the pp and pe modes ( p &lt; 0.05), and there were differences in the location of blocked tubes between the treatment modes.Blocked tubes occurred more often in the venous cauldron of the circuit in the pdf mode and in the plasma separator of the circuit in the pp mode.The incidence of tube blockage was significantly lower in patients with no more than 3 treatments than in those with 3 to 5 treatments and those with more than 5 treatments ( p &lt; 0.05).The incidence of catheter blockage was higher in patients with pta values ≤20% than in those with pta values between 20% and 30%, and higher than in those with pta values above 30% ( p &lt; 0.05).Conclusion .The risk factors of tube plugging in patients with liver failure treated with artificial liver include different treatment modes, different treatment times, and different pta values.The pdf mode has a higher rate of tube plugging than pe or pp treatment modes.The more the number of treatment times and the lower the pta value of patients, the more tube plugging is likely to occur.

Journal: Evidence-Based Complementary and Alternative Medicine (2023)
Publication types: Research Article;
Analysis of Prognostic Risk Factors of Sepsis Patients in Intensive Care Unit Based on Data Analysis

In this paper, a data-enabled analysis of the prognostic risk factors of sepsis patients in the intensive care unit is presented.For this purpose, we have selected 220 sepsis patients, preferably those admitted to the intensive care unit for treatment in a tertiary a hospital in tianjin from june 2018 to june 2019 and received complete data as the research objects, to explore the prognostic risk factors of sepsis patients in the intensive care unit.All patients met the ssc sepsis diagnosis guidelines and recorded the patients’ age, gender, underlying disease, and infection site.Laboratory indicators, such as blood routine, electrolytes, arterial blood gas, liver function, and renal function, were collected within 24 hours of admission.Furthermore, the corresponding specimens were cultured for pathogenic microorganisms according to the site of infection.The lac value was measured at admission and 24 h after admission, and the 24 h lactate clearance rate was calculated.The acute physiological and chronic health status score ii (apache-ii) and sofa score were calculated, which were based on the worst value of the index within 24 hours after admission.According to the prognosis of patients during hospitalization, they are divided into two groups: (i) survival group and (ii) death group.We entered all the data into excel and used spss21.0 statistical software for data analysis and processing.Quantitative data are tested for normality.Quantitative data for normal distribution are expressed as mean ± standard deviation, and normal distribution and uniform variance are measured.The factors affecting the prognosis of patients with sepsis were first subjected to a single-factor logistic regression analysis, and a multiple logistic regression analysis was performed on the basis of the significance of the single-factor analysis.The results found that the prognosis of patients with sepsis in the icu is affected by multiple factors such as underlying diseases, infectious microorganisms, comorbidities, and interventional therapy.Apache-ii score, 24 h lactate clearance rate, ards, and dic are independent risk factors that affect the prognosis of icu patients.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Analysis of Predictive Model of Coronary Vulnerable Plaque under Hemodynamic Numerical Simulation

Vulnerable plaque is considered to be the cause of most clinical coronary arteries, and linear cytokines are an important factor causing plaque instability.Early prediction of vulnerable plaque is of great significance in the treatment of cardiovascular diseases.Methods.Computational fluid dynamics (cfd) was used to simulate the hemodynamics around plaques, and the serum biochemical markers in 224 patients with low-risk acute coronary syndrome (acs) were analyzed.Vulnerable plaques were predicted according to the distribution of biochemical markers in serum.Results.Cfd can accurately capture the hemodynamic characteristics around the plaque.The patient’s age, history of hyperlipidemia, apolipoprotein b (apo b), adiponectin (adp), and s e-selection were risk factors for vulnerable plaque.Area under curve (auc) values corresponding to the five biochemical markers were 0.601, 0.523, 0.562, 0.519, 0.539, and the auc value after the combination of the five indicators was 0.826.Conclusion.The combination of multiple biochemical markers to predict vulnerable plaque was of high diagnostic value, and this method was convenient and noninvasive, which was worthy of clinical promotion.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Analysis of Curative Effect and Prognostic Factors of Radiotherapy for Esophageal Cancer Based on the CNN

An esophageal cancer intelligent diagnosis system is developed to improve the recognition rate of esophageal cancer image diagnosis and the efficiency of physicians, as well as to improve the level of esophageal cancer image diagnosis in primary care institutions.In this paper, by collecting medical images related to esophageal cancer over the years, we establish an intelligent diagnosis system based on the convolutional neural network for esophageal cancer images through the steps of data annotation, image preprocessing, data enhancement, and deep learning to assist doctors in intelligent diagnosis.The convolutional neural network-based esophageal cancer image intelligent diagnosis system has been successfully applied in hospitals and widely praised by frontline doctors.This system is beneficial for primary care physicians to improve the overall accuracy of esophageal cancer diagnosis and reduce the risk of death of esophageal cancer patients.We also analyze that the efficacy of radiation therapy for esophageal cancer can be influenced by many factors, and clinical attention should be paid to grasp the relevant factors in order to improve the final treatment effect and prognosis of patients.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Analysis of Clinical Effects of Comprehensive Nursing Based on Enhanced Recovery after Surgery in Patients with Embolization for Intracranial Aneurysms

This research sets out to elucidate the clinical effect of comprehensive nursing based on the concept of enhanced recovery after surgery (eras) in patients with embolization for intracranial aneurysms (ias).Methods.This study enrolled 119 patients with embolization for ias in the zhongnan hospital of wuhan university from january 2020 to january 2021 and divided them into two groups according to the perioperative care they received: a control group ( n = 39 ) treated with routine perioperative nursing and an observation group ( n = 80 ) treated with eras-based comprehensive nursing.Surgical indicators, neurological function (national institute of health stroke scale (nihss) score; scandinavian stroke scale (sss) score), anxiety and depression (self-rating anxiety scale (sas) score; self-rating depression scale (sds) score), incidence of adverse events, and patient satisfaction were compared.Results.The observation group had better surgical indicators and lower scores of nihss, sss, sas, and sds than the control group, accompanied by a lower incidence of adverse events and higher patient satisfaction.Conclusions.Eras-based comprehensive nursing can better promote patients’ neurological recovery after embolization for ias, relieve unhealthy emotions (depression, anxiety, etc.), and reduce the occurrence of adverse reactions, facilitating patient discharge.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Analysis of Carotid Ultrasound Screening of High-Risk Groups of Stroke Based on Big Data Technology

In order to understand detection of carotid atherosclerosis in the screening of high-risk stroke populations in a certain area of china, we have analyzed related risk factors of cas.In accordance with the requirements of the “2015 technical plan for the screening and intervention projects for high-risk stroke populations,” a cluster sampling method was used to select 4532 (number of screened persons from 2015 to 2021) permanent residents over 41 years old (一) in shaheying town, liulin town, chenggu county, hanzhong city, shaanxi province, and da’an town, ningqiang county, and nearby communities are selected as the screening targets.We screened out high-risk groups of stroke based on big data technology and understood the detection of cas.According to the screening results of big data technology, it was divided into two groups: cas group and non-cas group.The basic information, medical history, personal lifestyle, physical examination, and laboratory examination results of the two groups were classified and counted.The measurement data such as age and waist circumference of the two groups were tested by two independent samples, and the count data of gender, stroke history, hypertension, and other data were tested by the χ 2 test of the four-table data, and the logistic regression model was used to analyze the risk factors for cas of population at high risk of stroke.The results proved the following: (1) among the 4532 screeners, 865 cases were screened out of the high-risk population of stroke, with an average age of (58.5 ± 8.3) years, mainly 59 to 68 years old, accounting for 43.8%, and the male-to-female ratio was 1.6 : 1.(2) the detection rates of cas, intimal thickening, plaque formation, and stenosis among high-risk groups of stroke were 55.5%, 10.2%, 52.2%, and 32.6%, respectively.(3) among the high-risk groups of stroke, cas patients have a history of stroke, the proportion of hypertension, age, total cholesterol, and low-density lipoprotein cholesterol levels that are higher than those in the non-cas group, and the difference is statistically significant.(4) logistic regression analysis shows that age, diabetes, and low-density lipoprotein cholesterol are independent risk factors for cas in the high-risk population of stroke in this area.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Amyotrophic Lateral Sclerosis Symptom Score in Integrative Treatments (ALS-SSIT) for Evaluating Therapeutic Effect of Traditional Chinese Medicine: A Prospective Study

To evaluate the reliability, validity, sensitivity, and clinical applicability of a new scale—the amyotrophic lateral sclerosis symptom score in integrative treatments (als-ssit)—for measuring the effect of traditional chinese medicine (tcm) in patients with amyotrophic lateral sclerosis (als).Methods.A total of 160 patients with als were enrolled and followed up for 6 months.All patients received tcm.Patients were evaluated at enrollment and at the end of 6 months with a new scale, the als-ssit, developed after extensive consultations with tcm experts with several years of experience in the treatment of als.The 36-item medical outcomes study short form (sf-36) scale and the amyotrophic lateral sclerosis functional rating scale (alsfrs) were used as the reference standards.Results.The acceptance rate and completion rate of the als-ssit scale were high, and the content validity was confirmed by experts.Test-retest performed at enrollment and at 6 months showed good reliability of the als-ssit scale (cronbach α , 0.9172 and 0.9181, respectively).The als-ssit scale score showed significant change at 6 months, indicating the ability to reflect the change in disease severity.Conclusion.The als-ssit appears to be a feasible, reliable, and sensitive tool for the evaluation of the effect of tcm in patients with als.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Amidation-Modified Apelin-13 Regulates PPARγ and Perilipin to Inhibit Adipogenic Differentiation and Promote Lipolysis

With the adjustment of human diet and lifestyle changes, the prevalence of obesity is increasing year by year.Obesity is closely related to the excessive accumulation of white adipose tissue (wat), which can synthesize and secrete a variety of adipokines.Apelin is a biologically active peptide in the adipokines family.Past studies have shown that apelin plays an important regulatory role in the pathogenesis and pathophysiology of diseases such as the cardiovascular system, respiratory system, digestive system, nervous system, and endocrine system.Apelin is also closely related to diabetes and obesity.Therefore, we anticipate that apelin-13 has an effect on lipometabolism and intend to explore the effect of apelin-13 on lipometabolism at the cellular and animal levels.In in vitro experiments, amidation-modified apelin-13 can significantly reduce the lipid content; tg content; and the expression of pparγ, perilipin m rna, and protein in adipocytes.Animal experiments also show that amidation modification apelin-13 can improve the abnormal biochemical indicators of diet-induced obesity (doi) rats and can reduce the average diameter of adipocytes in adipose tissue, the concentration of glycerol, and the expression of pparγ and perilipin m rna and protein.Our results show that apelin-13 can affect the metabolism of adipose tissue, inhibit adipogenic differentiation of adipocytes, promote lipolysis, and thereby improve obesity.The mechanism may be regulating the expression of pparγ to inhibit adipogenic differentiation and regulating the expression of perilipin to promote lipolysis.This study helps us understand the role of apelin-13 in adipose tissue and provide a basis for the elucidation of the regulation mechanism of lipometabolism and the development of antiobesity drugs.

Journal: Bioinorganic Chemistry and Applications (2021)
Publication types: Research Article;
ALKBH5 Is Lowly Expressed in Esophageal Squamous Cell Carcinoma and Inhibits the Malignant Proliferation and Invasion of Tumor Cells

Modification of n6-methyladenosine (m6a) and rna m6a regulatory factors is required in cancer advancement.The contribution of m6a and its alteration in esophageal squamous cell carcinoma (escc) is still unclear.Results.Alkbh5 was lowly expressed in escc tissues, which the total m6a level was increased in escc tissue than the presentation in normal healthy tissue.The pc dna3.1-alkbh5 recombinant plasmid was transfected into kyse-150 and eca-109 cells.The overexpression of alkbh5 is responsible for a significant reduction of the total m6a levels in eca-109 and kyse150 cells, inhibiting the proliferation capability, migration, and cell invasion.Conclusions.Alkbh5 as a demethylase was lowly expressed in cancer progression of escc and acts as a crucial component in escc progression.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
Adverse Influences of Nonstrabismic Amblyopia on Quality of Life of Teenagers in China

The aim of this study was to explore the influences of nonstrabismic amblyopia on quality of life in adolescents.Health-related quality of life (hrqo l) scale, a multidimensional construct that indicates a fundamental health outcome, was used to measure physical and psychosocial functioning of the adolescents.Forty teenagers with nonstrabismic amblyopia and 40 control teenagers without nonstrabismic amblyopia were recruited between april 2019 and july 2021.The anthropometric measures, body image, physical activity outcome, and hrqo l scores including physical health, emotional functioning, social functioning, and school functioning were compared between the two groups.The results revealed that teenagers with nonstrabismic amblyopia had less weekly sedentary time ( p &lt; 0.001 ), weekly total steps ( p &lt; 0.001 ), and worse school functioning ( p = 0.0211 ) than control teenagers.No significant difference was found in anthropometric measures and body image between the two groups ( p &gt; 0.05 ).This study implied the needs for teenagers with nonstrabismic amblyopia to enhance physical activities.Teachers and parents are encouraged to pay more attention to teenagers with nonstrabismic amblyopia to improve their school functioning.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;