syedzayyan/paper_mill_benchmark huggingface dataset:
Relations between social attention, expressed positive affect and behavioral inhibition during play.

Flexible social attention, including visually attending to social interaction partners, coupled with positive affect may facilitate adaptive social functioning.However, most research assessing social attention relies on static computer-based paradigms, overlooking the dynamics of social interactions and limiting understanding of individual differences in the deployment of naturalistic attention.The current study used mobile eye-tracking to examine relations between social attention, expressed affect, and behavioral inhibition during naturalistic play in young children.Children (n= 28,mage= 6.12, 46.4% girls, 92.9% white) participated in a 5-min free play with a novel age- and sex-matched peer while mobile eye-tracking data were collected.Interactions were coded for social attention and expressed affect and modeled second-by-second, generating 4,399 observations.Children spent more time dwelling on toys than on peers or anywhere else in the room.Further analyses demonstrated children were almost twice as likely to gaze at their peer when simultaneously self-expressing positive affect.Additionally, children were more than twice as likely and more than three times as likely to self-express positive affect when dwelling on peer or in the presence of peer-expressed positive affect, respectively.Behavioral inhibition was not significantly related to social attention.However, children higher in behavioral inhibition were less likely to self-express positive affect in the presence of peer-expressed positive affect.The current results provide a snapshot of relations between social attention, expressed affect and individual differences during play and provide guidance for future work assessing the roles of social attention and positive affect in facilitating positive social interactions.(psyc info database record (c) 2022 apa, all rights reserved).

Journal: Developmental psychology (2022)
Publication types: Journal Article
Atopic Dermatitis Pathogenesis: Lessons From Immunology.

Translational research has changed the understanding of atopic dermatitis (ad) pathogenesis beyond the basic mechanisms of immunology.The study in patients of rational therapies based on targeted therapies (biologicals) provides valuable information from the patient and provides lessons of clinical immunology on clinically relevant mechanism of ad pathogenesis.Ad features such as skin barrier defect, skin dysbiosis, and pruritus share a common abnormal adaptive immune response process.Skin-homing cla+cd4+ memory t-cells produce il-4, il-13, and il-31 which are key mediators in ad pathogenesis.Lessons learned from ad show that translational immunology allows generating rational therapies for ad and learning its immunopathogenesis in the patient.

Journal: Dermatology practical & conceptual (2022)
Publication types: Journal Article;Review
Outcome of COVID-19-positive children with heart disease and grown-ups with congenital heart disease: A multicentric study from India.

Outcome data of children with heart disease who acquired covid-19 infection are limited.Aims we sought to analyze outcome data and identify risk factors associated with mortality in children with heart disease and grown-ups with congenital heart disease (guch) who had a laboratory-confirmed covid-19 infection.Settings and design this is a retrospective, multicentric, observational study.Materials and methods the study included children with heart disease and guch population, who presented with either symptomatic or asymptomatic covid-19 infection to any of the participating centers.Covid-19-negative patients admitted to these centers constituted the control group.Results from 24 pediatric cardiac centers across india, we included 94 patients with a median age of 12.5 (interquartile range 3-96) months and 49 (52.1%) patients were males.Majority (83 patients, 88.3%) were children.One-third of the patients (n= 31, 33.0%) had acyanotic congenital heart disease, and 41.5% (n= 39) were cyanotic, with > 80% of the patients being unoperated.Only 30 (31.9%) patients were symptomatic for covid-19 infection, while the rest were incidentally detected positive on screening.A total of 13 patients died (case fatality rate: 13.8%).The in-hospital mortality rate among hospitalized patients was significantly higher among covid-19-positive cases (13 of 48; 27.1%) as compared to covid-negative admissions (9.2%) during the study period (p< 0.001).On multivariate analysis, the independent predictors of mortality among covid-19-positive cases were severity of illness at admission (odds ratio [or]: 535.7, 95% confidence interval [ci]: 6.9-41,605,p= 0.005) and lower socioeconomic class (or: 29.5, 95% ci: 1.1-814.7,p= 0.046).Conclusions children with heart disease are at a higher risk of death when they acquire covid-19 infection.Systematic preventive measures and management strategies are needed for improving the outcomes.

Journal: Annals of pediatric cardiology (2021)
Publication types: Journal Article
Anaesthetic management of extra-pleural pneumonectomy and hyperthermic intrathoracic chemotherapy procedure.

Malignant pleural mesothelioma is a rare tumour with survival of 9-17 months after diagnosis.Radical surgical resection by extra-pleural pneumonectomy combined with hyperthermic intrathoracic chemotherapy has shown to improve patient survival and better microscopic tumour control.Anaesthetic management of this procedure is challenging due to the complex pathophysiological changes associated with prolonged duration of surgery, one- lung ventilation, haemodynamic instability due to major blood loss, temperature variations including heat loss during pneumonectomy and rapid rise in temperature during hyperthermic chemotherapy, cardiac arrhythmias due to exposure to heated chemotherapeutics, cisplatin toxicity and acid-base changes.Intra-operative management involves protective ventilation, regulation of temperature and haemodynamics along with prevention of complications associated with 'heated chemotherapeutics'.Thorough pre-operative assessment and preparation, advanced intra-operative monitoring with prompt corrective interventions, will help in improved patient outcome in the immediate post-operative period.We present one such case done for the 1(st) time in india.

Journal: Indian journal of anaesthesia (2015)
Publication types: Journal Article
Red seaweed extracts reduce methane production by altering rumen fermentation and microbial compositionin vitro.

A series ofin vitrobatch culture incubations were carried out to investigate changes in rumen fermentation characteristics, methane (ch4) production, and microbial composition in response to supplementation with five different red seaweed species (amphiroa anceps, aanc;asparagopsis taxiformis, atax;chondracanthus tenellus, cten;grateloupia elliptica, gell; and gracilaria parvispora, gpar).Prior to the incubations, the total flavonoid and polyphenol content of the red seaweed extracts was quantified.The incubated substrate consisted of timothy hay and corn grain [60:40 dry matter (dm) basis].Treatments were substrate mixtures without seaweed extract (con) or substrate mixtures supplemented with 0.25 mg/m l of red seaweed extract.Samples were incubated for 6, 12, 24, 36, and 48 h.Each sample was incubated in triplicates in three separate runs.in vitro dm degradability, fermentation parameters (i.e., p h, volatile fatty acids, and ammonia nitrogen), total gas production, and ch4production were analyzed for all time points.Microbial composition was analyzed using 16s r rna amplicon sequencing after 24 h of incubation.The highest ch4reduction (m l/g dm, m l/g digested dm, and % of total gas production) was observed in atax (51.3, 50.1, and 51.5%, respectively, compared to con;p< 0.001) after 12 h of incubation.The other red seaweed extracts reduced the ch4production (m l/g dm;p< 0.001) in the range of 4.6-35.0% compared to con after 24 h of incubation.After 24 h of incubation, supplementation with red seaweed extracts tended to increase the molar proportion of propionate (p= 0.057) and decreased the acetate to propionate ratio (p= 0.033) compared to the con.Abundances of the genus methanobrevibacterand total methanogens were reduced (p= 0.050 and p= 0.016) by red seaweed extract supplementation.The linear discriminant analysis effect size (p< 0.05, lda ≥ 2.0) showed that ug succinivibrionaceae,anaeroplasma, and ug ruminococcaceae, which are associated with higher propionate production, starch degradation, and amylase activity were relatively more abundant in red seaweed extracts than in the con.Our results suggest that supplementation with red seaweed extracts altered the microbiota, leading to the acceleration of propionate production and reduction in ch4production.

Journal: Frontiers in veterinary science (2022)
Publication types: Journal Article
Single-cell transcriptomics in bone marrow delineates CD56dimGranzymeK+subset as intermediate stage in NK cell differentiation.

Human natural killer (nk) cells in lymphoid tissues can be categorized into three subsets: cd56bright cd16+, cd56dim cd16+and cd69+cxcr6+lymphoid tissue-resident (lt)nk cells.How the three subsets are functionally and developmentally related is currently unknown.Therefore, we performed single-cell rna sequencing combined with oligonucleotide-conjugated antibodies against cd56, cxcr6, cd117 and cd34 on fresh bone marrow nk cells.A minor cd56dim gzm k+subset was identified that shared features with cd56brightand cd56dim gzm k-nk cells based on transcriptome, phenotype (nkg2ahigh cd16low klrg1high tigithigh) and functional analysis in bone marrow and blood, supportive for an intermediate subset.Pseudotime analysis positioned cd56bright, cd56dim gzm k+and cd56dim gzm k-cells in one differentiation trajectory, while lt nk cells were developmentally separated.Integrative analysis with bone marrow cells from the human cell atlas did not demonstrate a developmental connection between cd34+progenitor and nk cells, suggesting absence of early nk cell stages in bone marrow.In conclusion, single-cell transcriptomics provide new insights on development and differentiation of human nk cells.

Journal: Frontiers in immunology (2022)
Publication types: Journal Article
Effect of selected lifestyle factors on the nutrition state of elderly people with metabolic syndrome.

The formation and development of the metabolic syndrome (met s) is largely caused by lifestyle factors.Many studies have shown that excessive consumption of simple carbohydrates, alcohol, salt, physical inactivity and smoking increase the risk of met s.Objective the aim of the study was to assess the nutritional status and its relationship with selected lifestyle factors in elderly people with met s.Material and methods 81 people aged 51-75 participated in the study.According to the guidelines, all tests were performed on an empty stomach.The comparison of individual quantitative variables between the groups was performed using the student's t-test for independent measurements or using the mann-whitney u test.The relationship between quantitative variables was verified with the spearman's correlation coefficient.All statistical tests were based on a significance level of p<0.05.Results the bmi, the percentage of body fat and the waist circumference significantly exceed the norm for the population in the examined persons.The responses of respondents aged 51-65 show that 36% of people sweetened their drinks, 65.6% were salted their food, 51.6% consumed alcohol, and at the age of 66-75, respectively: 47.1%, 52.9%, 41.2%.There was no correlation between sweetening beverages and salting food and the concentration of glucose and lipids.However, a positive correlation was found between the amount of salt consumed and the heart rate (r=0.28, pp<0.05).In both age groups, statistically significant differences in the concentration of triglycerides depending on alcohol consumption or non-consumption were found.Due to the lack of precise data on the amount of alcohol consumed, the correlation between alcohol consumption and the concentration of glucose and lipids was not analyzed.Physical activity was not undertaken by 39.1% of patients aged 51-65 years and 41.2% of patients aged 66-75 years.In the group of elderly people without physical activity, a statistically significantly higher glucose concentration was found in relation to those who were physically active (130 mg/dl vs.105 mg/dl; p=0.031).Patients aged 51-65 who engaged physical activity had statistically significantly lower body weight, bmi, waist circumference and lean body mass, which requires further studies.Conclusions the anthropometric indices and parameters of met s patients indicated disturbances in the nutritional status.Unhealthy lifestyle was shown mainly in the younger group of patients 51-65 years old (they sweetened drinks more often, salted dishes, consumed alcohol).Patients with metabolic syndrome did not undertake physical activity as often as recommended.

Journal: Roczniki Panstwowego Zakladu Higieny (2022)
Publication types: Journal Article
Acoustic Mist Ionization Mass Spectrometry for Ultrahigh-Throughput Metabolomics Screening.

Incorporating safety data early in the drug discovery pipeline is key to reducing costly lead candidate failures.For a single drug development project, we estimate that several thousand samples per day require screening (<10 s per acquisition).While chromatography-based metabolomics has proven value at predicting toxicity from metabolic biomarker profiles, it lacks sufficiently high sample throughput.Acoustic mist ionization mass spectrometry (ami-ms) is an atmospheric pressure ionization approach that can measure metabolites directly from 384-well plates with unparalleled speed.We sought to implement a signal processing and data analysis workflow to produce high-quality ami-ms metabolomics data and to demonstrate its application to drug safety screening.An existing direct infusion mass spectrometry workflow was adapted, extended, optimized, and tested, utilizing three ami-ms data sets acquired from technical and biological replicates of metabolite standards and hep g2 cell lysates and a toxicity study.Driven by criteria to minimize variance and maximize feature counts, an algorithm to extract the pulsed scan data was designed; parameters for signal-to-noise-ratio, replicate filter, sample filter, missing value filter, and rsd filter were all optimized; normalization and batch correction strategies were adapted; and cell phenotype filtering was implemented to exclude high cytotoxicity samples.The workflow was demonstrated using a highly replicated hep g2 toxicity data set, comprising 2772 samples from exposures to 16 drugs across 9 concentrations and generated in under 5 h, revealing metabolic phenotypes and individual metabolite changes that characterize specific modes of action.This ami-ms workflow opens the door to ultrahigh-throughput metabolomics screening, increasing the rate of sample analysis by approximately 2 orders of magnitude.

Journal: Analytical chemistry (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Recent Approaches in the Catalytic Transformation of Biomass-Derived 5-Hydroxymethylfurfural into 2,5-Diformylfuran.

The conversion of biomass into a great variety of valuable chemicals, polymers, and fuels gives a sustainable alternative for the insufficiency of non-renewable fossil fuel resources and reduces environmental pollution.5-hydroxymethylfurfural (hmf), converted from sustainable carbohydrates, is a significant building block chemical, and the selective oxidation of hmf into 2,5-diformylfuran (dff) presents an ongoing challenge.Dff is a versatile platform molecule derived from biomass and has promising application in pharmaceuticals and polymers.This review provides an overview of the latest developments of efficient catalytic systems for the sustainable conversion of hmf to dff.

Journal: ChemSusChem (2022)
Publication types: Journal Article;Review
Familiarity impairments after anterior temporal-lobe resection with hippocampal sparing: Lessons learned from case NB.

We review evidence from an extensive single case study in an individual (nb) who underwent a rare left-sided anterior temporal-lobe resection with sparing of the hippocampus.Our study aimed to determine whether memory functions of perirhinal cortex, which was largely removed in the resection, can be impaired against a background of preserved hippocampus-dependent memory processing.This research was guided by the proposal that item-based familiarity assessment relies on contributions of perirhinal cortex, and that the hippocampus plays a unique role in the relational binding of items to episodic contexts, which is critical for recollection.Seven sets of findings have emerged from our research on nb (synthesized from five primary research articles), and from follow-up work in other patients: (i) familiarity impairments can be selective and be revealed with multiple methods; (ii) selective familiarity and selective recollection impairments can be double dissociated; (iii) selective familiarity impairments show material specificity; (iv) selective familiarity impairments extend to assessment of cumulative lifetime experience; (v) selective familiarity impairments are sensitive to degree of feature overlap between object concepts; (vi) selective familiarity impairments are associated with preserved task-related f mri signals in the hippocampus; (vii) selective familiarity impairments can be observed in other lesion cases.Despite our main focus on the dual-process framework, we also discuss implications for the functional organization of the medial temporal lobes in broader terms.We argue that our findings shed light on this organization even if the functional specialization of different medial temporal structures is ultimately not fully captured with reference to the cognitive distinction between familiarity and recollection.

Journal: Neuropsychologia (2020)
Publication types: Case Reports;Journal Article;Research Support, Non-U.S. Gov't
Effects of Luteolin on Biofilm ofTrueperella pyogenesand Its Therapeutic Effect on Rat Endometritis.

Trueperella pyogenesis an opportunistic pathogen that causes suppurative infections in animals.The development of new anti-biofilm drugs will improve the current treatment status for controlling t.Pyogenesinfections in the animal husbandry industry.Luteolin is a naturally derived flavonoid compound with antibacterial properties.In this study, the effects and the mechanism of luteolin on t.Pyogenesbiofilm were analyzed and explored.The mbic and mbec of luteolin on t.Pyogeneswere 156 μg/m l and 312 μg/m l, respectively.The anti-biofilm effects of luteolin were also observed by a confocal laser microscope and scanning electron microscope.The results indicated that 312 μg/m l of luteolin could disperse large pieces of biofilm into small clusters after 8 h of treatment.According to the real-time quantitative pcr detection results, luteolin could significantly inhibit the relative expression of the biofilm-associated geneslux s,plo,rbs bandlsr b.In addition, the in vivo anti-biofilm activity of luteolin against t.Pyogeneswas studied using a rat endometritis model established by glacial acetic acid stimulation and t.Pyogenesintrauterine infusion.Our study showed that luteolin could significantly reduce the symptoms of rat endometritis.These data may provide new opinions on the clinical treatment of luteolin and other flavonoid compounds on t.Pyogenesbiofilm-associated infections.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article
Pharmacokinetic-Pharmacodynamic Modelling of Systemic IL13 Blockade by Monoclonal Antibody Therapy: A Free Assay Disguised as Total.

A sequential pharmacokinetic (pk) and pharmacodynamic (pd) model was built with nonlinear mixed effects modelling based on data from a first-in-human trial of a novel biologic, medi7836.Medi7836 is a human immunoglobulin g1 lambda (ig g1λ-yte) monoclonal antibody, with an fc modification to reduce metabolic clearance.Medi7836 specifically binds to, and functionally neutralizes interleukin-13.Thirty-two healthy male adults were enrolled into a dose-escalation clinical trial.Four active doses were tested (30, 105, 300, and 600 mg) with 6 volunteers enrolled per cohort.Eight volunteers received placebo as control.Following single subcutaneous administration (sc), individual time courses of serum medi7836 concentrations, and the resulting serum il13 modulation in vivo, were quantified.A binding pharmacokinetic-pharmacodynamic (pk-pd) indirect response model was built to characterize the exposure-driven modulation of the target over time by medi7836.While the validated bioanalytical assay specification quantified the level of free target (i.e., a free il13 assay), emerging clinical data suggested dose-dependent increase in systemic il13 concentration over time, indicative of a total il13 assay.The target time course was modelled as a linear combination of free target and a percentage of the drug-target complex to fit the clinical data.This novel pk-pd modelling approach integrates independent knowledge about the assay characteristics to successfully elucidate apparently complex observations.

Journal: Pharmaceutics (2021)
Publication types: Journal Article
Do motor plans affect sensorimotor state estimates during temporal decision-making with crossed vs. uncrossed hands? Failure to replicate the dynamic crossed-hand effect.

Hermosillo et al.(j neurosci 31: 10019-10022, 2011) have suggested that action planning of hand movements impacts decisions about the temporal order judgments regarding vibrotactile stimulation of the hands.Specifically, these authors reported that the crossed-hand effect, a confusion about which hand is which when held in a crossed posture, gradually reverses some 320 ms before the arms begin to move from an uncrossed to a crossed posture or vice versa, such that the crossed-hand is reversed at the time of movement onset in anticipation of the movement's end position.However, to date, no other study has attempted to replicate this dynamic crossed-hand effect.Therefore, in the present study, we conducted four experiments to revisit the question whether preparing uncrossed-to-crossed or crossed-to-uncrossed movements affects the temporo-spatial perception of tactile stimulation of the hands.We used a temporal order judgement (toj) task at different time stages during action planning to test whether tojs are more difficult with crossed than uncrossed hands ("static crossed-hand effect") and, crucially, whether planning to cross or uncross the hands shows the opposite pattern of difficulties ("dynamic crossed-hand effect").As expected, our results confirmed the static crossed-hand effect.However, the dynamic crossed-hand effect could not be replicated.In addition, we observed that participants delayed their movements with late somatosensory stimulation from the toj task, even when the stimulations were meaningless, suggesting that the toj task resulted in cross-modal distractions.Whereas the current findings are not inconsistent with a contribution of motor signals to posture perception, they cast doubt on observations that motor signals impact state estimates well before movement onset.

Journal: Experimental brain research (2022)
Publication types: Journal Article