syedzayyan/paper_mill_benchmark huggingface dataset:
Efficacy and Mechanism of Trimebutine Maleate Combined with Lactulose in the Treatment of Constipation-Predominant Irritable Bowel Syndrome in the Elderly

Study on the efficacy and mechanism of trimebutine maleate combined with lactulose in the treatment of constipation-predominant irritable bowel syndrome (ibs-c) in the elderly.Methods.From march 2019 to march 2021, 102 elderly patients with ibs-c were randomly divided into the observation group (51 cases) and the control group (51 cases).The observation group was treated with trimebutine maleate combined with lactulose, while the control group was treated with lactulose.Comparison of the clinical effects of the two groups.Comparison of vasoactive intestinal peptide (vip) levels, neuropeptide y (npy) levels, and quality of life scores before and after treatment between the two groups.Documentation of adverse reactions during treatment.Results.The improvement of clinical symptoms in the observation group was significantly better than that in the control group, and the difference is statistically significant ( p &lt; 0.05 ).The level of vip after treatment in the observation group was significantly lower than that in the control group and before treatment, and the differences were statistically significant ( p &lt; 0.05 ).The level of npy after treatment in the observation group was significantly higher than that in the control group and before treatment, and the differences were statistically significant ( p &lt; 0.05 ).The scores of dietary restrictions and health worries in the control group after treatment were significantly higher than those before treatment, and the differences were statistically significant ( p &lt; 0.05 ).The scores of anxious, behavioral conflict, dietary restrictions, health worries, social response, and family relationship in the observation group after treatment were significantly higher than those in the control group and before treatment, and the differences were statistically significant ( p &lt; 0.05 ).There were no serious adverse effects in either group during the treatment period, with some patients experiencing dizziness and dry mouth, which improved after discontinuation of the drug, without special intervention.Conclusion.Trimebutine maleate combined with lactulose can improve clinical symptoms and quality of life in elderly patients with ibs-c, and its mechanism of action may be related to the regulation of the body’s vip and npy levels.

Journal: Emergency Medicine International (2022)
Publication types: Clinical Study;Research Article;
Effects of Modified Jianpi Qushi Heluo Decoction on Scores of TCM Syndromes, 24 h Urinary Albumin, and Plasma Albumin in IMN of Spleen-Kidney Qi Deficiency

To explore the effects of modified jianpi qushi heluo decoction on scores of tcm syndromes, 24 h urinary albumin (ua), and plasma albumin (alb) in idiopathic membranous nephropathy (imn) of spleen-kidney qi deficiency.Methods.A total of 84 patients with imn of spleen-kidney qi deficiency type admitted to the hospital were enrolled between november 2019 and september 2021.According to the random number table method, they were divided into the observation group (42 cases) and control group (42 cases).The control group was treated with routine western medicine, while the observation group was additionally treated with modified jianpi qushi heluo decoction.All were continuously treated for 2 months.The clinical curative effect between the two groups was compared.Before and after treatment, scores of tcm syndromes, biochemical indexes (24 h ua, plasma alb, serum triglyceride (tg), and serum cholesterol (tc)), and t lymphocyte subsets (th1, th2, th1/th2, and th17) were compared between the two groups.The occurrence of adverse reactions in both groups during treatment was recorded.Results.The difference in the total response rate of treatment between the observation group and control group was not statistically significant (90.48% vs.73.81%) ( p &gt; 0.05 ).After 2 months of treatment, scores of tcm syndromes in the observation group were significantly lower than those in the control group, levels of 24 h ua, tg, and tc were significantly lower than those in the control group, and alb was significantly higher than that in the control group ( p &lt; 0.05 ).After 2 months of treatment, levels of peripheral blood th1 and th17 in the observation group were significantly lower than those in the control group, while th2 and th1/th2 were higher than those in the control group ( p &lt; 0.05 ).The difference in incidence of adverse reactions between the observation group and control group was not statistically significant (4.76% vs.14.29%) ( p &gt; 0.05 ).Conclusion.The modified jianpi qushi heluo decoction can reduce ua, increase alb, and improve clinical symptoms and immune function of patients with imn of spleen-kidney qi deficiency.

Journal: Emergency Medicine International (2022)
Publication types: Clinical Study;Research Article;
Comparison of Curative Effect between PFNA and PCCP in the Treatment of Femoral Intertrochanteric Fractures

To compare and analyze the clinical efficacy of proximal femoral nail anti-rotation (pfna) and percutaneous compression plate (pccp) for minimally invasive treatment of femoral intertrochanteric fractures.Methods.A retrospective analysis of 98 patients with femoral intertrochanteric fractures admitted to our hospital from january 2019 to december 2020 was used as the research object, and they were divided into pfna group and pccp group according to different treatment methods, with 51 cases and 47 cases.The intraoperative and postoperative indicators were compared between the two groups of patients.Results.There was no significant difference in the operative time, postoperative fracture healing time, and harris score of hip joint function between the two groups (t = −1.43, 1.86, 1.63; p &gt; 0.05 ).Compared with the pfna group, the intraoperative blood loss and postoperative drainage volume in the pccp group were lower than those in the pfna group (t = 11.38, 9.66; p &lt; 0.05 ).Compared with the pfna group, the time of weight-bearing in the pccp group was longer than that in the pfna group (t = −2.23, p &lt; 0.05 ).The total incidence of postoperative complications was 7.84% in the pfna group and 10.64% in the pccp group, and there was no significant difference between the two groups ( p &gt; 0.05 ).Conclusion.The pfna and pccp are both effective measures for the clinical treatment of intertrochanteric fractures, and internal fixation should be reasonably selected according to the specific conditions of the patients.

Journal: Emergency Medicine International (2022)
Publication types: Research Article;
Synthesis of Zinc Oxide (ZnO)-Titanium Dioxide (TiO2)-Chitosan-Farnesol Nanocomposites and Assessment of Their Anticancer Potential in Human Leukemic MOLT-4 Cell Line

Leukemia is the most prevalent cancer in children and one of the most common and deadly cancers that affect adults.Several metal oxide nanoparticles, biopolymers, and phytochemicals have been discovered to target cancer cells selectively while inflicting low to no damage to healthy cells.Among the existing nanoparticle synthesis methodologies, biologically synthesized nanoparticles using phytochemicals have emerged as a straightforward, economical, and environmentally sound strategy.The synergistic antitumor potential of zn o‐ti o 2 ‐chitosan‐farnesol nanocomposites (ncs) against leukemia molt‐4 cells was investigated in the current study.After synthesizing the ncs, characterization of the same was carried out using xrd, dls, fesem, tem, pl, edx, and ftir spectroscopy.To analyze its anticancer activity, molt‐4 cells were cultured and treated at diverse dosages of ncs.The cell viability upon treatment was examined by mtt assay.The morphological and nuclear modifications were observed by dual staining.Ros and mmp levels were observed by dcfh‐da staining and rh‐123 dye, respectively.Furthermore, the caspase 3, 8, and 9 levels were examined by performing elisa.The xrd patterns exhibited a hexagonal structure of the ncs.In the dls spectrum, the hydrodynamic diameter of the ncs was observed to be 126.2 nm.The electrostatic interface between the zn o‐ti o 2 ‐chitosan‐farnesol ncs was confirmed by the ftir spectra.A significant loss of cell viability in a dosage‐dependent trend confirmed the cytotoxic effect of the ncs.An elevated ros level and mmp depletion suggested apoptosis‐associated cell death via the intrinsic pathway, which was confirmed by elevated expressions of caspase 3, 8, and 9 markers.Thus, the results showed that the synthesized ncs demonstrated a remarkable anticancer potential against leukemic cells and can be potentially valuable in cancer treatments.The findings from this study conclude that this is a new approach for modifying the physicochemical characteristics of zn o‐ti o 2 ‐chitosan‐farnesol composites to increase their properties and synergistically exhibit anticancer properties in human leukemic cancer cells.

Journal: Bioinorganic Chemistry and Applications (2022)
Publication types: Research Article;
Risk Spillover: A New Perspective on the Study of Financing Difficulties for SMEs—Evidence from China

Existing studies on the financing difficulties of middle- and small-sized enterprises (smes) have neglected the quantitative analysis of smes’ risk spillovers to banks.Therefore, taking china as an example, we have analyzed the financing difficulties of smes from the perspective of risk spillover.The garch time-varying copula-co va r model based on the skewed-t distribution was used to measure the risk spillover effects of smes on banks.Furthermore, the heterogeneous impacts of risk spillovers on different scale banks were analyzed, including state-owned banks, joint-stock banks, and city commercial banks.The study found that smes always have obvious risk spillover effects on banks; it is particularly difficult for smes to obtain loans from the largest state-owned banks because in extreme cases, smes have the highest risk spillover effects on state-owned banks.The changes in risk spillover effects are attributed to two reasons.One is that the degree of association between smes and various banks is different, and the other is that there are varying degrees of risk spillover effects among various banks.

Journal: Discrete Dynamics in Nature and Society (2021)
Publication types: Research Article;
Effects of Deep Hyperthermia Combined with Intraperitoneal Chemotherapy on Liver-Kidney Function, Immune Function, and Long-Term Survival in Patients with Abdominal Metastases

S.To analyze the effects of deep hyperthermia combined with intraperitoneal chemotherapy on liver-kidney function, immune function, and long-term survival in patients with abdominal metastases.Methods.A total of 88 patients with abdominal metastases confirmed in the hospital were enrolled as the research objects between august 2018 and august 2021.They were randomly divided into control group (n = 44) and observation group (n = 44).The control group was treated with intraperitoneal chemotherapy, while observation group was additionally treated with deep hyperthermia.The general clinical data of patients were recorded.The short-term and long-term curative effects were evaluated.The occurrence of side effects in both groups was recorded.Before and after treatment, levels of alanine transaminase (alt) and aspartate transaminase (ast) were detected by full-automatic biochemical analyzer.The level of blood urea nitrogen (bun) was detected by the urease electrode method.The level of serum creatinine (scr) was detected by the picric acid method.The levels of cd3+, cd4+, cd8+, and nk cells were detected by bd facscalibur flow cytometer.Results.There was no significant difference in clinical data between the two groups ( p &gt; 0.05 ).In the observation group, orr was significantly higher than that in the control group (54.55% vs 29.55%) ( p &lt; 0.05 ), os was significantly longer than that in the control group ( p &lt; 0.05 ), and median survival time and m pfs were longer than those in the control group.After treatment, the levels of alt, ast, bun, and scr were significantly increased in the control group ( p &lt; 0.05 ), but there was no significant difference in peripheral blood cd3+, cd4+, and cd4+/cd8+ ratio or count of nk cells before and after treatment ( p &gt; 0.05 ).Before and after treatment, there was no significant difference in the levels of alt, ast, bun, and scr in the observation group ( p &gt; 0.05 ).After treatment, peripheral blood cd3+, cd4+, and cd4+/cd8+ ratio and count of nk cells were all increased in the observation group, significantly higher than those in the control group ( p &lt; 0.05 ).The incidence of chemotherapy side effects in the observation group was significantly lower than that in the control group ( p &lt; 0.05 ).Conclusion.The short-term and long-term curative effects of deep hyperthermia combined with intraperitoneal chemotherapy are good on patients with intraperitoneal metastases, with less damage to liver-kidney function.It is beneficial to enhance immune function of patients, with mild side effects.

Journal: Emergency Medicine International (2023)
Publication types: Clinical Study;Research Article;
Impact of Different Electrolytes on the Machining Rate in ECM Process

Electrochemical machining is a nonconventional machining process in which the metal removal is achieved by the electricity and chemical solution known as an electrolyte.It is the reverse electrolysis process where the application of electricity facilitates the current travel in between anode and cathode.The mechanism of the ion movement is similar to the electrolysis process.Electrochemical machining (ecm) is a type of advanced machining process which employs electricity to perform the machining process on the workpiece.It is also known as a reverse electroplating process where metal removal is achieved instead of metal deposition on the metal surface.There are various parameters that affect the metal removal process in the ecm process, such as electrolyte, power supply, workpiece material, and tool material.The electrolyte is one of the key factors impacting the machining rate, surface finish, and reliability of the produced parts.In this project, a brief study is carried out regarding the electrochemical process and the electrolytes where the properties, functions, merits, and demerits are evaluated.The impact of the various electrolytes and their suitability for machining of various metals is also discussed.The findings of the effect produced by using the mixture of the electrolyte in the electrochemical machining process are discussed in this project.The effects of the complexing agents on the electrolyte and the electrochemical process as a whole are also reviewed.

Journal: Advances in Materials Science and Engineering (2021)
Publication types: Research Article;
Postcare for Repairing Nerve and Tendon Injury Based on Biomimetic Nano-Parallel Material Composite Protein

Natural tendons are composed of ordered parallel arrangement of bundles of type i collagen fibers.It is responsible for transmitting the forces generated by the bones and muscles to move the body.Tendon injuries are common sports injuries, accounting for 50% of sports injuries.In adulthood, factors such as few tendon tissue cells and poor blood supply make it difficult to heal on their own after injury.Therefore, restoring the structure and function of native tendon tissue is still an unsolved problem.The purpose of this study is to study the use of biomimetic nano-parallel material composite proteins to induce the directional differentiation of stem cells to tendon lineages to promote muscle regeneration and repair.This study proposes to prepare composite protein nanomaterials by simulating the parallel arrangement of tendon collagen fibers.This can facilitate the directed differentiation of fibroblasts into tendon lineages.It can use the bp algorithm in the neural network algorithm to simulate the parallel arrangement of tendon collagen fibers, which is more efficient than other schemes.The experimental results in this study show that the rat cells are repaired after about 6 weeks.Tendon repair enters a remodeling phase with reduced cell numbers, collagen, and mucopolysaccharide synthesis.During this period, tendon repair gradually changes from the cellular level to the tissue level, and tenocyte metabolism remains high.Tenocytes and collagen fibers are aligned in the direction of stress.A higher proportion of collagen 1 synthesis occurs during this period.Collagen 1 accounts for 65% to 80% of the dry weight of the tendon, which plays the most important role in the mechanical properties of the tendon.

Journal: Advances in Materials Science and Engineering (2022)
Publication types: Research Article;
Streamline Effect Improvement of Additive Manufactured Airfoil Utilizing Dynamic Stream Control Procedure

In the era of fast transport, to create inventive stream flow management solutions that are capable of diminishing the aerodynamic drag of the vehicles, there is a need to modify the flow characteristics over the vehicle by deferring or expelling the position of the flow partition.The objective of this study involves the parameterized design of an airfoil utilizing the bezier curve technique with the assistance of the simulation program.For flow regulations, synthetic jet modules are ingrained at different percentages of the chord to manage the stall characteristics.The parametrization system, combined with the stream control method, can give a much better insight into flow re-energization and pave some way for the reduction of the wake.Digital fabrication technique (3d printing or rapid prototyping method) is used to fabricate the end product for aerodynamic testing.The comparative outcome showed a reduction in drag at certain angles of attack due to the surface finish obtained.By comparing the results, the aerodynamic efficiency showed a significant rise of 13.05% at lower angles of attack when compressed gas was used in the synthetic jet closer to the frontier edge of the airfoil.Near the stall angle of attack, the coefficient of lift (cl) and coefficient of drag (cd) values showed no progress.

Journal: Advances in Materials Science and Engineering (2022)
Publication types: Research Article;
Implementation of TQM and the Integration of BIM in the Construction Management Sector in Saudi Arabia

Total quality management (tqm) is based on the conceptions of managing and enhancing the success of construction projects.When applied, tqm improves execution of time management of project, satisfies clients’ needs, minimizes the expenses and increases the profit of contractor, and fulfils safety regulations on the construction site.This research is aimed at evaluating the impacts of employing the concepts of tqm to the construction projects in saudi arabia.The results of the study were obtained through utilization of a descriptive analytical approach, where 300 questionnaires were distributed to engineering firms and companies with a response rate of 200 questionnaires, hence achieving the study sample for this research.The data gathered was analyzed by applying the statistical package for social science (spss) program and calculating the relative importance index (rii) and the mean values.From the research conducted, the outcomes showed that the management’s ability to commit using tqm while applying bim obtained a relative importance of (0.717), while the relative importance for the management’s ability to commit using tqm without the application of bim is (0.552).The results showed that construction projects in saudi arabia still sustain setbacks from applying tqm concepts and suffer from the lack of administrative, scientific, and technical applications.

Journal: Advances in Materials Science and Engineering (2021)
Publication types: Research Article;
Fabrication of Hollow Needle Tips with Nanoholes by Plasma Maskless Processing and Calculation and Detection of Complex Surface Edges

The plasma maskless processing method combines the advantages of plasma etching and scanning probe processing, such as high etching efficiency, wide range of applicable materials, and high resolution.This method is based on the probe driving and detection of piezoelectric thin films, which enables all probes in the array to be processed completely independently, greatly improving the overall processing efficiency, and can effectively etch specific nano-scale regions of various materials.And it provides an effective solution for efficiently processing small batches of multi-variety micro-nano devices.In this study, a hollow needle tip with nanoholes was fabricated by plasma maskless processing, and use edge computing to calculate the complex surface shape of the needle tip.By establishing a plasma reactor, using the calculation method of the complex surface edge of the needle tip, and testing the stability of the processed nanotip by means of filling air pressure and power excitation in the experiment.The results show that when the breakdown voltage sf6 discharges, with the increase of air pressure, the breakdown voltage of the arrester first decreases and then increases gradually, and it is the smallest at 5 k pa and reaches the optimal 490 v, (pd) m = 0.5 pa·m.And the ar reaction ionization potential (15.76 e v) and excitation potential (11.53 e v, 11.72 e v) are lower than the splitting potential (≥16 e v) of sf6.As time goes on, high-energy particles are neutralized with the vessel wall, so the ion concentration is gradually smaller, sparse between 200 and 250, and increases from 100 to 300, which is close to the peak value, according to the gradual increase of the discharge voltage.The data obtained from the experimental test proves the reliability of the nanotips prepared in this study, and the properties remain stable under different breakdown voltages.Therefore, the nanohole hollow tip processed by maskless scanning plasma in this study has reached the standard of process use and has important application significance.

Journal: Advances in Materials Science and Engineering (2022)
Publication types: Research Article;
Development of Microbiology Plantation-Based Multimodal Segmentation for Smart Garden Using Machine Learning

Normally, gardens lower the ambient temperature, which would improve air quality, absorb pollutants, and produce oxygen.Trees reduce soil erosion, increase fertility, and help retain soil moisture.Decomposed leaves that fall in the garden become nutrients for tree growth and help microbes to thrive.When it comes to growing trees in a garden, one should try and choose native trees that are naturally found in a particular area.These trees are well adapted to the environment and require less maintenance.Many insects and birds rely on native trees for food and shelter.Therefore, they are best for the environment.However, not all native trees are evergreen trees.Many evergreen trees can be planted in a small garden.In this paper, a microplantation-based model was developed to enhance the biological impacts for a smart garden.Based on the garden requirements, the smart system was constructed.On this basis, the seeds are planted in the soil.

Journal: Advances in Materials Science and Engineering (2022)
Publication types: Research Article;