syedzayyan/paper_mill_benchmark huggingface dataset:
Monitoring tools for early identification of children with developmental delay in India: an update.

Developmental screening is challenging in both developed countries and developing countries.An estimated 10% of children experience developmental delay leading to disability in india.Unfortunately, the indian literature is limited regarding early identification and intervention of developmental delays in youngsters, given multiple barriers in implementing screening.Quick screening tools can easily be integrated into the routine work-up of infants and young children in the primary health-care system and the literature has shown the efficiency of early identification and intervention for children born with high-risk profiles.Therefore, validated screening tools may improve the early identification of developmental delay in young children, further enhancing the clinical outcome of children with developmental delays.India introduced the first development screening tool in 1991, the baroda development screening test (bdst), followed by developmental assessment scale for indian infants (dasii), trivandrum development screening chart (tdsc).Indian researchers have adapted few development screening tools from standardized tools available from western countries.This review highlights the different screening tools adapted in india, psychometric properties and adapted items to the gold standard, critical appraisal of most commonly used screening tools and description on strengths and limitations.The goal is to help clinicians understand the rationale behind each tool and the different domains evaluated as per the child's needs.

Journal: Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence (2022)
Publication types: Journal Article;Review
Injury intensifies T cell mediated graft-versus-host disease in a humanized model of traumatic brain injury.

The immune system plays critical roles in promoting tissue repair during recovery from neurotrauma but is also responsible for unchecked inflammation that causes neuronal cell death, systemic stress, and lethal immunodepression.Understanding the immune response to neurotrauma is an urgent priority, yet current models of traumatic brain injury (tbi) inadequately recapitulate the human immune response.Here, we report the first description of a humanized model of tbi and show that tbi places significant stress on the bone marrow.Hematopoietic cells of the marrow are regionally decimated, with evidence pointing to exacerbation of underlying graft-versus-host disease (gvhd) linked to presence of human t cells in the marrow.Despite complexities of the humanized mouse, marrow aplasia caused by tbi could be alleviated by cell therapy with human bone marrow mesenchymal stromal cells (mscs).We conclude that mscs could be used to ameliorate syndromes triggered by hypercytokinemia in settings of secondary inflammatory stimulus that upset marrow homeostasis such as tbi.More broadly, this study highlights the importance of understanding how underlying immune disorders including immunodepression, autoimmunity, and gvhd might be intensified by injury.

Journal: Scientific reports (2020)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Biomass ash pyrolyzed from municipal sludge and its adsorption performance toward tetracycline: effect of pyrolysis temperature and KOH activation.

Large amount of municipal sludge is difficult to handle; its resource utilization is an effective measure.In this study, the municipal sludge from sewage treatment plant was pyrolyzed without gas protection at different temperatures and potassium hydroxide (koh) concentrations for activation.The pyrolysis products, named biomass ash, with higher surface area and enriched pore structures could be obtained at the pyrolysis temperature of 773 k.Moreover, the koh activation for raw municipal sludge could further increase the surface area of the pyrolysis biomass ash.The maximum specific surface area was 44.71 m2/g, which was obtained under 2 mol/l koh activation before pyrolysis at 773 k.And in this situation, the obtained pyrolysis biomass ash as adsorbent showed the maximum adsorption capacity of 50.75 mg/g toward tetracycline (tc).Moreover, the tc adsorption onto pyrolysis biomass ash obtained under various conditions followed the pseudo-second-order kinetic model.Adsorption thermodynamics analysis suggested the tc adsorption onto the pyrolysis biomass ash with no pre-activation was mainly due to the multi-molecule heterogeneous adsorption, while the tc adsorption onto pyrolysis biomass ash pretreated through the activation of koh followed the monomer adsorption mechanism.This different adsorption mechanism was largely related to the pore structure, polarity, and aromaticity of the adsorbent.

Journal: Environmental science and pollution research international (2022)
Publication types: Journal Article
Two-stage hepatectomy with radioembolization for bilateral colorectal liver metastases: A case report.

Two-stage hepatectomy (tsh) is a well-established surgical technique, used to treat bilateral colorectal liver metastases (crlm) with a small future liver remnant (flr).However, in classical tsh, drop-out is reported to be around 25%-40%, due to insufficient flr increase or progression of disease.Trans-arterial radioembolization (tare) has been described to control locally tumor growth of liver malignancies such as hepatocellular carcinoma, but it has been also reported to induce a certain degree of contralateral liver hypertrophy, even if at a lower rate compared to portal vein embolization or ligation.Case summary herein we report the case of a 75-year-old female patient, where tsh and tare were combined to treat bilateral crlm.According to computed tomography (ct)-scan, the patient had a hepatic lesion in segment vi-vii and two other confluent lesions in segment ii-iii.Therefore, one-stage posterior right sectionectomy plus left lateral sectionectomy (lls) was planned.The liver volumetry estimated a flr of 38% (segments i-iv-v-viii).However, due to a more than initially planned, extended right resection, simultaneous lls was not performed and the patient underwent selective tare to segments ii-iii after the first surgery.The ct-scan performed after tare showed a reduction of the treated lesion and a flr increase of 55%.Carcinoembryonic antigen and ca 19.9 decreased significantly.Nearly three months later after the first surgery, lls was performed and the patient was discharged without any postoperative complications.Conclusion according to this specific experience, tare was used to induce liver hypertrophy and simultaneously control cancer progression in tsh settings for bilateral crlm.

Journal: World journal of hepatology (2021)
Publication types: Case Reports;Journal Article
Prevalence of COVID-19 Mimics in the Emergency Department.

Due to the lack of specific clinical manifestations and symptoms, it is difficult to distinguish covid-19 from mimics.A common pitfall is to rush to make a diagnosis when encountering a patient with covid-19-like symptoms.The present study describes a series of covid-19 mimics using an outpatient database collected from a designated covid-19 healthcare facility in tokyo, japan.Methods we established an emergency room (er) tailored specifically for patients with suspected or confirmed covid-19 called the "covid-er." in this single-center retrospective cohort study, we enrolled patients who visited the covid-er from february 1 to september 5, 2020.The outcomes included the prevalence of covid-19, admission, potentially fatal diseases and final diagnosis.Results we identified 2,555 eligible patients.The median age was 38 (interquartile range, 26-57) years old.During the study period, the prevalence of covid-19 was 17.9% (457/2,555).Non-covid-19 diagnoses accounted for 82.1% of all cases.The common cold had the highest prevalence and accounted for 33.0% of all final diagnoses, followed by gastroenteritis (9.4%), urinary tract infections (3.8%), tonsillitis (2.9%), heat stroke (2.6%) and bacterial pneumonia (2.1%).The prevalence of potentially fatal diseases was 14.2% (298/2,098) among non-covid-19 patients.Conclusion several potentially fatal diseases remain masked among the wave of covid-19 mimics.It is imperative that a thorough differential diagnostic panel be considered prior to the rendering of a covid-19 diagnosis.

Journal: Internal medicine (Tokyo, Japan) (2021)
Publication types: Journal Article
Executive function "drives" differences in simulated driving performance between young adults with and without autism spectrum disorder.

Individuals with autism spectrum disorder (asd) may experience greater difficulty learning to drive than peers who do not have asd, but reasons for those differences are unclear.This study examined how diagnostic symptoms of asd and commonly co-morbid executive dysfunction relate to differences in simulated driving performance between young, inexperienced drivers with and without asd.Participants included 98 young adults, ages 16-26 years, half of which were diagnosed with asd.Participants with asd completed the autism diagnostic observation schedule (ados-2) and self- and parent-report versions of the social responsiveness scale (srs-2) to confirm diagnosis and assess the severity of asd symptoms.All participants completed neuropsychological tests measuring executive functioning.Driving behaviors, including speed and lane positioning, were assessed on a virtual reality driving simulator.Analyses were conducted to first examine relationships between autism severity and driving behaviors, and then to examine whether neurocognitive performance mediated differences in driving behaviors between young adults with and without asd.Controlling for age, gender, and licensure status, asd symptom severity was not significantly related to driving.Neurocognitive variables were grouped into three factors: speed of information processing, auditory attention and working memory, and selective and divided attention.Speed of information processing significantly mediated group driving differences.Results suggest that assessment of executive functions such as processing speed may be more useful than the diagnostic assessment of asd symptoms for evaluation of driving readiness.

Journal: Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Percutaneous Transsplenic Balloon-Assisted Transjugular Intrahepatic Portosystemic Shunt Placement in Patients with Portal Vein Obliteration for Portal Vein Recanalization: Feasibility, Safety and Effectiveness.

To assess the feasibility, safety and effectiveness of portal vein recanalization (pvr)-transjugular portosystemic shunt (tips) placement via splenic access using a balloon puncture technique.Materials and methods in a single-center retrospective study from march 2017 to february 2021, 14 consecutive patients with portal hypertension, chronic liver disease and portal vein occlusion or near-complete (> 95%) occlusion were referred for pvr-tips placement.Feasibility, safety and effectiveness including procedural characteristics such as technical success, complication profile and splenic access time (sat), balloon positioning time (bpt), conventional portal vein entry time (cpvet), overall procedure time (opt), fluoroscopy time (ft), dose-area product (dap) and air kerma (ak) were evaluated.Results transsplenic pvr-tips using balloon puncture technique was technically feasible in 12 of 14 patients (8 men, 49 ± 13 years).In two patients without detectable intrahepatic portal vein branches, tips placement was not feasible and both patients were referred for further treatment with nonselective beta blockers and endoscopic variceal ligation.No complications grade > 3 of the cardiovascular and interventional radiological society of europe classification system occurred.The sat was 25 ± 21 min, cpvet was 33 ± 26 min, the opt was 158 ± 54 min, the ft was 42 ± 22 min, the dap was 167.84 ± 129.23 gy*cm2and the ak was 1150.70 ± 910.73 m gy.Conclusions transsplenic pvr-tips using a balloon puncture technique is feasible and appears to be safe in our series of patients with obliteration of the portal vein.It expands the interventional options in patients with chronic pvt.

Journal: Cardiovascular and interventional radiology (2022)
Publication types: Journal Article
Analysis of Representations of the Aid That Public Psychological Support Points Provide to Adolescent Female Victims of Gender-Based Violence: Reformulation of Policies and Practices.

Gender-based violence in adolescence has become a social health problem that is creating great concern and interest worldwide.In this regard, knowledge of the role taken by the professionals responsible for screening, detecting, referring, and caring for adolescent victims is essential to be able to understand the phenomenon and its characteristics in a practical way.In this sense, psychologists specialising in the care of victims of adolescent gender-based violence have complete and in-depth knowledge, not only of the phenomenon itself and the way in which it is presented in society, but also of the features presented by these victims and the aspects that need to be worked on during the intervention process.Given this context, a series of interviews with psychologists specialised in the care of gender-based violence victims were subjected to a qualitative deductive/inductive analysis.These interviews addressed the psychologists' theoretical-practical knowledge about the adolescent gender-based violence phenomenon.The analysis of the results points to the victims' irrational ideas regarding abusive relationships, to the form in which psychological support points are organised to help the victims, and to the strengths, weaknesses, and needs of these centres for them to be able to improve their operation and effectiveness in providing comprehensive care for adolescents beyond the psychological consultations themselves.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Sleep and high-risk behavior in military service members: a mega-analysis of four diverse U.S. Army units.

Experimental sleep restriction and deprivation lead to risky decision-making.Further, in naturalistic settings, short sleep duration and poor sleep quality have been linked to real-world high-risk behaviors (hrb), such as reckless driving or substance use.Military populations, in general, tend to sleep less and have poorer sleep quality than nonmilitary populations due to a number of occupational, cultural, and psychosocial factors (e.g.Continuous operations, stress, and trauma).Consequently, it is possible that insufficient sleep in this population is linked to hrb.To investigate this question, we combined data from four diverse united states army samples and conducted a mega-analysis by aggregating raw, individual-level data (n = 2,296, age 24.7 ± 5.3).A negative binomial regression and a logistic regression were used to determine whether subjective sleep quality (pittsburgh sleep quality index [psqi], insomnia severity index [isi], and duration [h]) predicted instances of military-specific hrb and the commission of any hrb (yes/no), respectively.Poor sleep quality slightly elevated the risk for committing hrbs (psqi exp(b): 1.12 and isi exp(b): 1.07), and longer duration reduced the risk for hrbs to a greater extent (exp(b): 0.78), even when controlling for a number of relevant demographic factors.Longer sleep duration also predicted a decreased risk for commission of any hrb behaviors (exp(b): 0.71).These findings demonstrate that sleep quality and duration (the latter factor, in particular) could be targets for reducing excessive hrb in military populations.These findings could therefore lead to unit-wide or military-wide policy changes regarding sleep and hrb.

Journal: Sleep (2021)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.
What is the effect of MRI with targeted biopsies on the rate of patients discontinuing active surveillance? A reflection of the use of MRI in the PRIAS study.

The reduction of overtreatment by active surveillance (as) is limited in patients with low-risk prostate cancer (pca) due to high rates of patients switching to radical treatment.Mri improves biopsy accuracy and could therewith affect inclusion in or continuation of as.We aim to assess the effect of mri with target biopsies on the total rate of patients discontinuing as, and in particular discontinuation due to grade group (gg) reclassification.Methods three subpopulations included in the prospective prias study with gg 1 were studied.Group a consists of patients diagnosed before 2009 without mri before or during as.Group b consists of patients diagnosed without mri, but all patients underwent mri within 6 months after diagnosis.Group c consists of patients who underwent mri before diagnosis and during follow-up.We used cumulative incidence curves to estimate the rates of discontinuation.Results in group a (n = 500), the cumulative probability of discontinuing as at 2 years is 27.5%; gg reclassification solely accounted for 6.9% of the discontinuation.In group b (n = 351) these numbers are 30.9 and 22.8%, and for group c (n = 435) 24.2 and 13.4%.The three groups were not randomized, however, baseline characteristics are highly comparable.Conclusions performing an mri before starting as reduces the cumulative probability of discontinuing as at 2 years.Performing an mri after already being on as increases the cumulative probability of discontinuing as in comparison to not performing an mri, especially because of an increase in gg reclassification.These results suggest that the use of mri could lead to more patients being considered unsuitable for as.Considering the excellent long-term cancer-specific survival of as before the mri era, the increased diagnostic accuracy of mri could potentially lead to more overtreatment if definitions and treatment options of significant pca are not adapted.

Journal: Prostate cancer and prostatic diseases (2021)
Publication types: Journal Article
Alterations in peripheral joint muscle force control in adults with musculoskeletal disease, injury, surgery, or arthroplasty: A systematic review and meta-analysis.

To systematically review and analyse whether musculoskeletal conditions affect peripheral joint muscle force control (i.e.Magnitude and/or complexity of force fluctuations).Methods a literature search was conducted using medline, cinahl and sportdiscus databases (from inception-8th april 2021) for studies involving: 1) participants with musculoskeletal disease, injury, surgery, or arthroplasty in the peripheral joints of the upper/lower limb; 2) comparison with an unaffected control group or unaffected contralateral limb; and 3) measures of the magnitude and/or complexity of force fluctuations during targeted isometric contractions.The methodological quality of studies was evaluated using a modified downs and black quality index.Studies were combined using the standardized mean difference (smd) in a random-effects model.Results 14 studies (investigating 694 participants) were included in the meta-analysis.There was a significant effect of musculoskeletal conditions on peripheral joint muscle force coefficient of variation (cv; smd = 0.19 [95 % ci 0.06, 0.32]), whereby individuals with musculoskeletal conditions exhibited greater cv than controls.Subgroup analyses revealed that cv was only greater: 1) when comparison was made between symptomatic and asymptomatic individuals (rather than between affected and contralateral limbs; smd = 0.22 [95 % ci 0.07, 0.38]); 2) for conditions of the knee (smd = 0.29 [95 % ci 0.14, 0.44]); and 3) for acl injury post-surgery (smd = 0.56 [95 % ci 0.36, 0.75]).Conclusion musculoskeletal conditions result in an increase in peripheral joint muscle force cv, with this effect dependent on study design, peripheral joint, and surgical status.The greater force cv is indicative of decreased force steadiness and could have implications for long-term tissue health/day-to-day function.

Journal: Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology (2022)
Publication types: Journal Article;Meta-Analysis;Review;Systematic Review
Serum microRNA as liquid biopsy biomarker for the prediction of oncological outcomes in patients with bladder cancer.

S radical cystectomy is the gold-standard treatment for muscle-invasive bladder cancer and aggressive non-muscle-invasive bladder cancer.To enhance clinical decision-making regarding patients with bladder cancer who underwent radical cystectomy, a recurrence prediction biomarker with high accuracy is urgently needed.In this study, we developed a model for the prediction of bladder cancer recurrence after radical cystectomy by combining serum micro rna and a pathological factor.Methods we retrospectively analyzed the clinical records of 81 patients with bladder cancer who underwent radical cystectomy between 2008 and 2016.The dataset was divided into two, and fisher linear discriminant analysis was used to construct a prognostic model for future recurrence in the training set (n = 41).The performance of the model was evaluated in the validation set (n = 40).Results thirty patients had recurrence after having undergone radical cystectomy.A prognostic model for recurrence was constructed by combining a pathological factor (i.e.Positive pathological lymph node status) and three micro rnas (mi r-23a-3p, mi r-3679-3p, and mi r-3195).The model showed a sensitivity of 0.87, a specificity of 0.80, and an area under the receiver operating characteristic curve of 0.88 (0.77-0.98) in the validation set.Furthermore, kaplan-meier analysis revealed that patients with a low prediction index have significantly longer overall survival than patients with a high prediction index (p = 0.041).Conclusion a combination of serum micro rna profiles and lymph node statuses is useful for the prediction of oncological outcomes after radical cystectomy in patients with bladder cancer.

Journal: International journal of urology : official journal of the Japanese Urological Association (2022)
Publication types: Journal Article
Repeatability of radiographic assessments for feline hip dysplasia suggest consensus scores in radiology are more uncertain than commonly assumed.

Variation in the diagnostic interpretation of radiographs is a well-recognised problem in human and veterinary medicine.One common solution is to create a 'consensus' score based on a majority or unanimous decision from multiple observers.While consensus approaches are generally assumed to improve diagnostic repeatability, the extent to which consensus scores are themselves repeatable has rarely been examined.Here we use repeated assessments by three radiologists of 196 hip radiographs from 98 cats within a health-screening programme to examine intra-observer, inter-observer, majority-consensus and unanimous-consensus repeatability scores for feline hip dysplasia.In line with other studies, intra-observer and inter-observer repeatability was moderate (63-71%), and related to the reference assessment and time taken to reach a decision.Consensus scores did show reduced variation between assessments compared to individuals, but consensus repeatability was far from perfect.Only 75% of majority consensus scores were in agreement between assessments, and based on bayesian multinomial modelling we estimate that unanimous consensus scores can have repeatabilities as low as 83%.These results clearly show that consensus scores in radiology can have large uncertainties, and that future studies in both human and veterinary medicine need to include consensus-uncertainty estimates if we are to properly interpret radiological diagnoses and the extent to which consensus scores improve diagnostic accuracy.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't