syedzayyan/paper_mill_benchmark huggingface dataset:
Correction: The potential role of borophene as a radiosensitizer in boron neutron capture therapy (BNCT) and particle therapy (PT).

Correction for 'the potential role of borophene as a radiosensitizer in boron neutron capture therapy (bnct) and particle therapy (pt)' by pengyuan qi et al., biomater.Sci., 2020, 8, 2778-2785,

Journal: Biomaterials science (2021)
Publication types: Journal Article
Decreasing incidence of complex regional pain syndrome in the Netherlands: a retrospective multicenter study.

Complex regional pain syndrome type i (crps) is a symptom-based diagnosis of which the reported incidence varies widely.In daily practice, there appears to be a decrease in incidence of crps after a distal radius fracture and in general.Questions/purposes the aim of this study was to assess the trend in the incidence of crps after a distal radius fracture and in general in the netherlands from 2014 to 2018.Methods the incidence of crps after a distal radius fracture was calculated by dividing the number of confirmed cases of crps after distal radius fracture by the total number of patients diagnosed with a distal radius fracture.Medical records of these patients were reviewed.Hospital-based data were used to establish a trend in incidence of crps in general.A dutch national database was used to measure the trend in the incidence of crps in the netherlands by calculating annual incidence rates: the number of new crps cases, collected from the national database, divided by the dutch mid-year population.Results the incidence of crps after distal radius fracture over the whole study period was 0.36%.Hospital data showed an absolute decrease in crps cases from 520 in 2014 to 223 in 2018.National data confirmed this with a decrease in annual incidence from 23.2 (95% ci: 22.5-23.9) per 100,000 person years in 2014 to 16.1 (95% ci: 15.5-16.7) per 100,000 person years in 2018.Conclusion a decreasing trend of crps is shown in this study.We hypothesize this to be the result of the changing approach towards crps and fracture management, with more focus on prevention and the psychological aspects of disproportionate posttraumatic pain.Level of evidence level 3 (retrospective cohort study).

Journal: British journal of pain (2022)
Publication types: Journal Article
Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials.

S to update our previously reported systematic review and meta-analysis of observational studies on cardiovascular drug exposure and covid-19 clinical outcomes by focusing on newly published randomized controlled trials (rcts).Methods more than 500 databases were searched between 1 november 2020 and 2 october 2021 to identify rcts that were published after our baseline review.One reviewer extracted data with other reviewers verifying the extracted data for accuracy and completeness.Results after screening 22 414 records, we included 24 and 21 rcts in the qualitative and quantitative syntheses, respectively.The most investigated drug classes were angiotensin-converting enzyme inhibitors (aceis)/angiotensin receptor blocker (arbs) and anticoagulants, investigated by 10 and 11 studies respectively.In meta-analyses, acei/arbs did not affect hospitalization length (mean difference -0.42, 95% confidence interval [ci] -1.83; 0.98 d, n = 1183), covid-19 severity (risk ratio/rr 0.90, 95% ci 0.71; 1.15, n = 1661) or mortality (risk ratio [rr] 0.92, 95% ci 0.58; 1.47, n = 1646).Therapeutic anticoagulation also had no effect (hospitalization length mean difference -0.29, 95% ci -1.13 to 0.56 d, n = 1449; severity rr 0.86, 95% ci 0.70; 1.04, n = 2696; and, mortality rr 0.93, 95% ci 0.77; 1.13, n = 5689).Other investigated drug classes were antiplatelets (aspirin, 2 trials), antithrombotics (sulodexide, 1 trial), calcium channel blockers (amlodipine, 1 trial) and lipid-modifying drugs (atorvastatin, 1 trial).Conclusion moderate- to high-certainty rct evidence suggests that cardiovascular drugs such as aceis/arbs are not associated with poor covid-19 outcomes, and should therefore not be discontinued.These cardiovascular drugs should also not be initiated to treat or prevent covid-19 unless they are needed for an underlying currently approved therapeutic indication.

Journal: British journal of clinical pharmacology (2022)
Publication types: Journal Article;Meta-Analysis;Review;Systematic Review;Research Support, Non-U.S. Gov't
First Report of Acute Myocarditis Post-Pfizer-BioNTech COVID-19 Vaccination in the Kingdom of Bahrain.

We present a case of a 24-year-old male patient who presented to our institution five days after receiving his first dose of pfizer-bio ntech vaccine to rule out acute coronary syndrome due to chest pain along with troponin increase and ecg changes.Acute coronavirus disease 2019 (covid-19) infection was excluded based on a negative real-time reverse transcription-polymerase chain reaction (rt-pcr) test of specimens acquired using nasopharyngeal swabs for severe acute respiratory syndrome coronavirus 2 (sars-co v-2), and all other viral serologies were found to be negative.Coronary angiogram showed normal coronaries, and the presence of late gadolinium enhancement, which is indicative of myocarditis, was identified using cardiac magnetic resonance imaging (mri).Our case report raises concern that the covid-19 vaccine may cause myocarditis as a rare side effect.

Journal: Cureus (2021)
Publication types: Case Reports;Journal Article
Broflanilide effectively controls Helicoverpa armigera and Spodoptera exigua exhibiting diverse susceptibilities to chlorantraniliprole and emamectin benzoate.

The cotton bollworm, helicoverpa armigera (hübner), and the beet armyworm, spodoptera exigua (hübner), are two major polyphagous lepidopteran pests of cultivated crops.They develop various levels of resistance to many frequently applied broad-spectrum insecticides.Here, the larval susceptibilities of a laboratory population and six field-collected populations per pest from hunan province, china to three insecticides were determined using a standard leaf-dipping method in the laboratory.Field-plot trials were conducted to verify the control efficacies of broflanilide 100 g l-1suspension concentrate (sc), chlorantraniliprole 5% sc and emamectin benzoate 5.7% water-dispersible granule, against h.Armigera and s.Exigua larvae using foliar sprays in 2013 and 2019.Results variations among h.Armigera and s.Exigua field populations in their susceptibility levels to the three insecticides were observed in linli, yueyang and changsha counties from 2013 to 2019.They were still high susceptibility to broflanilide only, but developed low and/or moderate levels of resistance to chlorantraniliprole and emamectin benzoate.In addition, broflanilide at 25 g ha-1provided an excellent control efficacy of 81.92% to 96.46% against these pests during the 3-14-days period after treatment in both years, whereas chlorantraniliprole at 50 g ha-1and emamectin benzoate at 4.5 g ha-1exhibited significantly decreased efficacies, which were consistent with their corresponding toxicity levels.Conclusions these results suggest that broflanilide should be an important new tool for the effective control of diamide- and avermectin-resistant h.Armigera and s.Exigua.© 2020 society of chemical industry.

Journal: Pest management science (2021)
Publication types: Journal Article
The trait and state negative affect can be separately predicted by stable and variable resting-state functional connectivity.

Many emotional experiences such as anxiety and depression are influenced by negative affect (na).Na has both trait and state features, which play different roles in physiological and mental health.Attending to na common to various emotional experiences and their trait-state features might help deepen the understanding of the shared foundation of related emotional disorders.Methods the principal component of five measures was calculated to indicate individuals' na level.Applying the connectivity-based correlation analysis, we first identified resting-state functional connectives (fcs) relating to na in sample 1 (n = 367), which were validated through an independent sample (n = 232; sample 2).Next, based on the variability of fcs across large timescale, we further divided the na-related fcs into high- and low-variability groups.Finally, fcs in different variability groups were separately applied to predict individuals' neuroticism level (which is assumed to be the core trait-related factor underlying na), and the change of na level (which represents the state-related fluctuation of na).Results the low-variability fcs were primarily within the default mode network (dmn) and between the dmn and dorsal attention network/sensory system and significantly predicted trait rather than state na.The high-variability fcs were primarily between the dmn and ventral attention network, the fronto-parietal network and dmn/sensory system, and significantly predicted the change of na level.Conclusions the trait and state na can be separately predicted by stable and variable spontaneous fcs with different attentional processes and emotion regulatory mechanisms, which could deepen our understanding of na.

Journal: Psychological medicine (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Micro-cantilever-based fiber optic hydrophone fabricated by a femtosecond laser.

We report an open cavity, cantilever-based fiber optic fabry-perot interferometer hydrophone.The hydrophone is made of fused silica material, and its micro-cantilever beam is directly fabricated by femtosecond (fs) laser micromachining.The theoretical analyses and experimental verifications of the frequency response of the sensor are presented.

Journal: Optics letters (2017)
Publication types: Journal Article
Chronic Eosinophilic Pneumonia Masquerading as a Lung Mass.

Lung masses are becoming more common, and although most are tumors, benign or malignant, some are not solid masses.Many pathologies can present as lung nodules, including lung cancers, hamartomas, lung abscesses, granulomas, and eosinophilic pneumonia, to name a few.A 40-year-old woman with a long history of smoking presented with cough and left-sided chest pain.After multiple imaging studies, she was thought to have a lung malignancy; however, multiple biopsies proved this was not the case.The histology reports of 3 to 4 biopsies at separate times indicated chronic inflammation ongoing in the lungs without any cancer cells present.She was treated for chronic eosinophilic pneumonia with a resolution of symptoms.The purpose of this case report is to discuss a case that was initially thought to be a lung mass but found to be chronic eosinophilic pneumonia manifesting as a lung mass.

Journal: Journal of investigative medicine high impact case reports (2022)
Publication types: Case Reports;Journal Article
Not just conspiracy theories: Vaccine opponents and proponents add to the COVID-19 'infodemic' on Twitter.

In february 2020, the world health organization announced an 'infodemic' -- a deluge of both accurate and inaccurate health information -- that accompanied the global pandemic of covid-19 as a major challenge to effective health communication.We assessed content from the most active vaccine accounts on twitter to understand how existing online communities contributed to the 'infodemic' during the early stages of the pandemic.While we expected vaccine opponents to share misleading information about covid-19, we also found vaccine proponents were not immune to spreading less reliable claims.In both groups, the single largest topic of discussion consisted of narratives comparing covid-19 to other diseases like seasonal influenza, often downplaying the severity of the novel coronavirus.When considering the scope of the 'infodemic,' researchers and health communicators must move beyond focusing on known bad actors and the most egregious types of misinformation to scrutinize the full spectrum of information -- from both reliable and unreliable sources -- that the public is likely to encounter online.

Journal: Harvard Kennedy School misinformation review (2020)
Publication types: Journal Article
Mapping O-glycosylation Sites Using OpeRATOR and LC-MS.

O-glycosylation is a difficult posttranslational modification to analyze.O-glycans are labile and often cluster making their analysis by lc-ms very challenging.Ope rator is an o-glycan specific protease that cleaves the protein backbone n-terminally of glycosylated serine and threonine residues.This enables the generation of glycopeptides of suitable size for mapping o-glycosylation sites in detail by bottom-up lc-ms analysis.In this chapter we demonstrate a simple workflow for in-depth analysis of o-glycosylation sites on heavily glycosylated proteins using ope rator digestion and hilic-ms/ms analysis.

Journal: Methods in molecular biology (Clifton, N.J.) (2021)
Publication types: Journal Article
Rapid unfolding of pig pancreas α-amylase: Kinetics, activity and structure evolution.

Α-amylase plays an important role in food processing and in-vivo digestion.Many biological functions of α-amylase are affected by unfolding.The pre-steady-state rapid unfolding kinetics of α-amylase remains unknown.In this study, the rapid unfolding kinetics of porcine pancreatic α-amylase (ppa) with guanidine hydrochloride (gdm hcl) were investigated by stopped-flow spectroscopy.Structural characterization of ppa by fluorescence spectroscopy, and molecular dynamics simulation showed that the unfolding process of ppa might start from the internal active center, where the β-sheet structure was destroyed, followed by the exposure of hydrophobic amino acid residues.Further research revealed that gdm hcl denaturized ppa not by complexing with ppa.The surrounding h-bond network of water was changed by gdm hcl.This research improves our understanding of the unfolding kinetics of the ppa on the microsecond scale.It also provides the evidence experimentally of the surrounding water contribution to protein denaturization.

Journal: Food chemistry (2022)
Publication types: Journal Article
Development of a slovenian version of the pittsburgh sleep quality index (PSQI-SLO) for use with older adults.

Poor sleep quality predicts poor quality of life, poor self-rated health, and chronic diseases and mental disorders among older adults.The pittsburgh sleep quality index (psqi) is the most widely used self-report measure of sleep quality in older adults.Objectives this study aimed to assess internal reliability, face validity, content validity and internal consistency of the slovenian version of the psqi (psqi-slo) for sleep quality in older adults.Methods a cross-sectional study was used to evaluate content and face validity as well as reliability (ɑ, ω and item-total correlations).Residents of 13 nursing homes and community-dwelling older adults from all regions of slovenia were sampled.A total of 831 participants aged 65 years and older participated in the study between march and august 2019.Results all items were successfully translated to slovenian.A minor cultural adaptation was made to improve the clarity of the meaning of all items.None of the items had an item content validity index (i-cvi) score lower than 0.50.Kappa indices were excellent for half of the items and good for the remainder.Internal consistency agreed with prior research (ɑ = 0.74).Intraclass correlation coefficient for global psqi-slo was 0.62 (p < 0.001).The total score of psqi-slo (8.09 ± 3.64 (95%, ci = 7.85-8.34)) was expected and comparable.Fifty-eight and four tenths' per cent (95%, ci = 55%-62%) had at least one chronic disease and 40% (95%, ci = 37%-42%) lived in a nursing home.Conclusions psqi-slo showed adequate internal consistency and test-retest reliability, and adequate construct and criterion validity.The instrument can be important in assessing older adults' subjective sleep quality in nursing homes, home environment and clinical settings.

Journal: International journal of older people nursing (2022)
Publication types: Journal Article
Characteristics of Post-ICU and Post-COVID Recovery Clinics in 29 U.S. Health Systems.

The multifaceted long-term impairments resulting from critical illness and covid-19 require interdisciplinary management approaches in the recovery phase of illness.Operational insights into the structure and process of recovery clinics (rcs) from heterogeneous health systems are needed.This study describes the structure and process characteristics of existing and newly implemented icu-rcs and covid-rcs in a subset of large health systems in the united states.Design cross-sectional survey.Setting thirty-nine rcs, representing a combined 156 hospitals within 29 health systems participated.Patients none.Interventions none.Measurement and main results rc demographics, referral criteria, and operating characteristics were collected, including measures used to assess physical, psychologic, and cognitive recoveries.Thirty-nine rc surveys were completed (94% response rate).Icu-rc teams included physicians, pharmacists, social workers, physical therapists, and advanced practice providers.Funding sources for icu-rcs included clinical billing (n= 20, 77%), volunteer staff support (n= 15, 58%), institutional staff/space support (n= 13, 46%), and grant or foundation funding (n= 3, 12%).Forty-six percent of rcs report patient visit durations of 1 hour or longer.Icu-rc teams reported use of validated scales to assess psychologic recovery (93%), physical recovery (89%), and cognitive recovery (86%) more often in standard visits compared with covid-rc teams (psychologic, 54%; physical, 69%; and cognitive, 46%).Conclusions operating structures of rcs vary, though almost all describe modest capacity and reliance on volunteerism and discretionary institutional support.Icu- and covid-rcs in the united states employ varied funding sources and endorse different assessment measures during visits to guide care coordination.Common features include integration of icu clinicians, interdisciplinary approach, and focus on severe critical illness.The heterogeneity in rc structures and processes contributes to future research on the optimal structure and process to achieve the best postintensive care syndrome and postacute sequelae of covid outcomes.

Journal: Critical care explorations (2022)
Publication types: Journal Article
Personalized tDCS for Focal Epilepsy-A Narrative Review: A Data-Driven Workflow Based on Imaging and EEG Data.

Conventional transcranial electric stimulation(t es) using standard anatomical positions for the electrodes and standard stimulation currents is frequently not sufficiently selective in targeting and reaching specific brain locations, leading to suboptimal application of electric fields.Recent advancements in in vivo electric field characterization may enable clinical researchers to derive better relationships between the electric field strength and the clinical results.Subject-specific electric field simulations could lead to improved electrode placement and more efficient treatments.Through this narrative review, we present a processing workflow to personalize t es for focal epilepsy, for which there is a clear cortical target to stimulate.The workflow utilizes clinical imaging and electroencephalography data and enables us to relate the simulated fields to clinical outcomes.We review and analyze the relevant literature for the processing steps in the workflow, which are the following: tissue segmentation, source localization, and stimulation optimization.In addition, we identify shortcomings and ongoing trends with regard to, for example, segmentation quality and tissue conductivity measurements.The presented processing steps result in personalized t es based on metrics like focality and field strength, which allow for correlation with clinical outcomes.

Journal: Brain sciences (2022)
Publication types: Journal Article;Review
P2R Inhibitors Prevent Antibody-Mediated Complement Activation in an Animal Model of Neuromyelitis Optica : P2R Inhibitors Prevent Autoantibody Injury.

Purinergic 2 receptors (p2rs) contribute to disease-related immune cell signaling and are upregulated in various pathological settings, including neuroinflammation.P2r inhibitors have been used to treat inflammatory diseases and can protect against complement-mediated cell injury.However, the mechanisms behind these anti-inflammatory properties of p2r inhibitors are not well understood, and their potential in cns autoimmunity is underexplored.Here, we tested the effects of p2r inhibitors on glial toxicity in a mouse model of neuromyelitis optica spectrum disorder (nmosd).Nmosd is a destructive cns autoimmune disorder, in which autoantibodies against astrocytic surface antigen aquaporin 4 (aqp4) mediate complement-dependent loss of astrocytes.Using two-photon microscopy in vivo, we found that various classes of p2r inhibitors prevented aqp4-ig g/complement-dependent astrocyte death.In vitro, these drugs inhibited the binding of aqp4-ig g or mog-ig g to their antigen in a dose-dependent manner.Size-exclusion chromatography and circular dichroism spectroscopy revealed a partial unfolding of antibodies in the presence of various p2r inhibitors, suggesting a shared interference with ig g antibodies leading to their conformational change.Our study demonstrates that p2r inhibitors can disrupt complement activation by direct interaction with ig g.This mechanism is likely to influence the role of p2r inhibitors in autoimmune disease models and their therapeutic impact in human disease.

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Research Support, N.I.H., Extramural
Congenital Great Toe Hypoplasia Equivalent to a Grade 3 Hypoplastic Thumb in a Patient with VACTERL Association.

Lower limb malformations in vacterl patients are extremely rare and the most common anomalies are found in the tibial ray.We present the case of a 15 month old male with vacterl and, additionally, a hypoplastic hallucal ray of the right foot in conjunction with a floating preaxial polydactyly.The great toe hypoplasia is similar to a grade 3b thumb hypoplasia with absence of the proximal two-thirds of the first metatarsal on the plain x-ray.We would like to draw the attention of hand surgeons to anomalies of the tibial ray, which, although rare, are the most common pattern of lower limb malformations in vacterl association.All patients with vacterl defects should be assessed for these additional findings.

Journal: The journal of hand surgery Asian-Pacific volume (2018)
Publication types: Case Reports;Journal Article