syedzayyan/paper_mill_benchmark huggingface dataset:
Levels of bioactive endogenous lipids and health-related quality of life in Chronic Idiopathic Axonal Polyneuropathy.

Although neuropathic pain is a significant problem in polyneuropathy, the underlying molecular mechanisms are poorly understood.The endogenous bioactive lipids 2-arachidonoyl-glycerol (2-ag), oleoylethanolamide (oea), palmitoylethanolamide (pea), and stearoylethanolamide (sea) are known to influence pain and inflammation in the peripheral nervous system.The aim of this study was to explore the plasma levels of endocannabinoids and related lipids and health-related quality of life in patients with polyneuropathy with and without pain.Methods patients (n= 48) with chronic idiopathic axonal neuropathy were included.Clinical data were retrieved from medical files.All patients filled out the sf-36 and eq-5d questionnaires.In addition, blood samples were analyzed for 2-ag, oea, pea, and sea.Results neuropathic pain was reported in 21 of the patients.There were significantly lower levels of 2-ag in patients with neuropathic pain (p= 0.03), but there were no significant differences in oea (p= 0.61), pea (p= 0.95), or sea (p= 0.97) levels.The patients reporting pain in the hands had significantly lower sea levels, 10.0 versus 15.0 (p= 0.03).The levels of 2-ag were significantly higher among patients reporting paresthesia in their feet (80.1 vs.56.3;p= 0.02).Levels of pea, sea, and 2-ag were decreased in patients with loss of vibration.Pea and sea were decreased in patients with loss of pain and temperature, and sea decreased in patients with loss of sense of touch.However, the differences in the levels of bioactive endogenous lipids were not statistically significant when corrected for multiple comparisons.Conclusion alterations of 2-ag levels between polyneuropathy patients with and without neurogenic pain indicate that it could play an essential role.Further studies are warranted.

Journal: Upsala journal of medical sciences (2022)
Publication types: Journal Article
Solid-phase microextraction of sulfonylurea herbicides by using borate-reinforced multiple monolithic fibers.

Boron-nitrogen coordination is a useful interaction for use in the extraction of amino-nitrogen-containing compounds.A new monolithic adsorbent is described here that consisted of poly(acrylamidophenyl boronic acid/vinyl-3-octylimidazolium tetrafluroborate-co-divinylbenzene/ethylene dimethacrylate) polymer.It was synthesized with the aim to obtain a new kind of extraction phase for multiple monolith based fiber solid-phase microextraction of sulfonylurea herbicides.Results indicate that boron-nitrogen coordination interaction plays a key role in the efficient extraction.It is also found that soaking the sorbent in a borate solution further improves the enrichment performance.The preparation conditions and extraction parameters were optimized.Following extraction with the adsorbent, the sulfonylurea herbicides were submitted to quantitation by hplc with dad detection.The limits of detection are in the range of 9.0-18 ng·l-1.The method was applied to monitor the herbicides in samples of tap, river and waste waters.Recoveries at spiking levels of 1.0, 10 and 100 μg·l-1are in the range of 70.1-108%, and the values for relative standard deviation are less than 10% for all analytes in all cases.Graphical abstract schematic of the monolith-based adsorbent (mba) on a multiple monolith based fiber (mmf) for use in solid-phase microextraction of sulfonylurea herbicides (sus).

Journal: Mikrochimica acta (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Adsorbate-adsorbent potential energy function from second virial coefficient data: a non-linear Hopfield Neural Network approach.

The hopfield neural network has been successfully applied to solve ill-posed inverse problems in different fields of chemistry and physics.In this work, the non-linear approach for this method will be applied to retrieve the empirical parameters of potential energy function, [formula: see text], between adsorbate and adsorbent from experimental data.Since the adsorption data is related to the second virial coefficient and therefore to [formula: see text] through an integral equation, the hopfield neural network will be used to find the best parameters which fits the experimental data.Initially simulated results will be analyzed to verify the method performance for data sets with and without noise addition.Then, experimental data for adsorption of propionitrile on activated carbon will be treated.Results presented here corroborate to the robustness of this method.

Journal: Journal of molecular modeling (2022)
Publication types: Journal Article
Additive Manufacturing with Thermoplastic Collagen.

Thermoplastic collagen is a partially denatured collagen powder which can be processed by thermoplastic methods such as extrusion and injection molding, but was hitherto not adapted for the use in additive manufacturing (am) techniques.This paper describes the first successful application of collagen/water/glycerol mixtures in an am process using a bio scaffolder 3.2 from ge si m mb h.Strands of molten collagen were deposited onto a building platform forming differently shaped objects.The collagen melt was characterized rheologically and optimal processing conditions were established.The technique includes the use of supporting structures of pla/wood composite for samples with complex geometry as well as post-processing steps such as the removal of the supporting structure and manual surface smoothing.The manufactured objects are characterized concerning water solubility, swelling behavior and compressibility.Possible applications are in the non-medical sector and include collagen-based pet food or customized organ models for medical training.

Journal: Polymers (2022)
Publication types: Journal Article
A case of non-necrotising herpetic retinitis.

In developed countries, the main origin of posterior uveitis is an infection.Herpes is the most common viral agent, as it has a wide spectrum of ocular manifestations.These manifestations may depend on the immunological state of the patient, and range from a mild focal form of non - necrotising herpetic retinitis (nnhr) to a severe form of acute retinal necrosis (arn).A case of nnhr due to herpes simplex virus type 2 (hsv-2) is reported, along with the different differential diagnostics prior to its diagnosis: atypical ocular toxoplasmosis, ocular tuberculosis, and arn.During its course, despite the antiviral treatment, systemic corticoids and the clinical improvement of the injury, there was a drastic drop in the visual acuity.This event led to the re-evaluation of the suspected entities, establishing the nnhr as a definitive diagnostic by exclusion, which was a diagnostic challenge.

Journal: Archivos de la Sociedad Espanola de Oftalmologia (2021)
Publication types: Case Reports;Journal Article
Alternative Approach for the Surgical Treatment of Left Main Coronary Artery Aneurysm.

Left main coronary artery (lmca) aneurysm is a very rare condition that usually requires surgical treatment.Although there is no consensus on the standard surgical technique, aneurysmal ligation with coronary artery bypass grafting is commonly used.This report presents a case of a giant lmca aneurysm for which an alternative surgical approach was performed.The aneurysm was incised and partially resected.An interposition right internal thoracic artery graft from the lmca to the left circumflex coronary artery was placed together with a left internal thoracic artery and free right internal thoracic artery graft.Postoperative imaging showed good patency of all grafts.This case demonstrates an effective approach for the surgical treatment of lmca aneurysm that offers an alternative when other techniques are not desirable.

Journal: The Annals of thoracic surgery (2019)
Publication types: Case Reports;Journal Article
Long- and short-term survival following laparoscopic and open pancreaticoduodenectomy for patients with periampullary tumors in Vietnam.

Laparoscopic pancreaticoduodenectomy (lpd) is a less invasive alternative to the traditional open pancreaticoduodenectomy (opd) approach used to treat periampullary tumors.However, previous studies examining the advantages of this surgery over opd have produced mixed results.Here, a retrospective observational approach was used to compare the short- and long-term outcomes of patients with periampullary tumors who underwent lpd or opd at a single institution in vietnam.Materials and methods data were obtained from hospital medical records collected over five years from patients that underwent opd or lpd.Information on demographics, medical status, tumor characteristics, operative variables, complications, and mortality was examined.Survival curves were constructed and the stepwise multivariate cox proportional hazard model was used to identify the factors associated with the risk of death following surgery.Results eighty-four patients aged 26-80 years were included.Twenty-two patients underwent lpd and 62 received opd.The operative time for the lpd group was significantly longer than that for the opd group, and the lpd group was less likely to require a blood transfusion during surgery.While the short- and long-term survival rates did not differ for the procedures, the factors associated with the risk of death following surgery were tumors at the n1 stage and an age >65 years.Conclusion both lpd and opd procedures for treating periampullary tumors exhibited comparable safety profiles, with similar short-term outcomes and long-term survival rates observed.Future studies with a larger sample size should be conducted to further examine the treatment outcomes following these surgical approaches.

Journal: Annals of medicine and surgery (2012) (2021)
Publication types: Journal Article
Clinical significance of pregnancy in adolescence in Japan.

We examined the clinical characteristics and obstetric outcomes in adolescent pregnancies in japanese women.Methods the present study was a retrospective investigation of all primiparous japanese women with singleton pregnancies who gave birth at ≥22 weeks' gestation aged ≤18 years old (adolescent pregnancy, n = 325) and aged 28-30 years old (n = 2029) at japanese red cross, katsushika maternity hospital between 2002 and 2016.Results the frequencies of smoking, economic problems, an unmarried single status at delivery and the start of prenatal care in the first trimester in the adolescent pregnancy group were significantly higher than in the control group (p < .01).The incidences of chlamydia trachomatis, condyloma acuminatum, and mental disorders in the adolescent pregnancy group were significantly higher than in the control group (p < .01).Pregnancy in adolescence was not related to adverse obstetric outcomes except preterm delivery (p = .02).Conclusions adolescent pregnancy was not associated with adverse obstetric outcomes; however, adequate social, economic, and mental support is needed for adolescent pregnant women.

Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2019)
Publication types: Journal Article
Temporal Tendinitis in Craniomandibular Dysfunction (CMD) - Does it Really Exist? A Temporomandibular MRI Investigation.

S the aim of the study was to analyze the role of temporal muscle and particularly tendon pathology in patients suffering from craniomandibular dysfunction (cmd) using magnetic resonance imaging.Materials and methods retrospective analysis of mri examinations was carried out with regard to temporal muscle fibrosis and fatty degeneration and particularly temporal tendon rupture, thickening, and degenerative signal alterations.Descriptive statistics and the mann-whitney u-test were used for statistical evaluation.Results structural lesions of temporal muscle parenchyma were the absolute exception.Pd hyperintensity, pronounced contrast enhancement, or peritendinous fluid collections along the temporal tendon were found only to a small extent, and a (partial) rupture occurred in only one case.The tendon diameter showed only slight variability.The mann-whitney u-test provided no results indicating a causal connection between degenerative joint or disc disease and temporal tendon pathology.Conclusion a large sample of 128 magnetic resonance imaging examinations provided no evidence of a major role of temporal tendinitis in clinical cmd syndrome.Key points · retrospective analysis of temporal tendon in cmd patients..· abnormal structural findings along the tendon seen only rarely..· obviously no crucial role of temporal tendon lesions in cmd syndrome..Citation format · stimmer h, grill f, waschulzik b et al.Temporal tendinitis in craniomandibular dysfunction (cmd) - does it really exist?A temporomandibular mri investigation.Fortschr röntgenstr 2022; 194: 1242 - 1249.

Journal: RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin (2022)
Publication types: Journal Article
A Rare Case of Acute Calculous Cholecystitis With Gallbladder Hydrops.

Gallbladder hydrops or mucocele is usually due to the obstruction of the gallbladder by a gallstone.It is usually characterized by an increase in gallbladder volume, which remains clinically silent and is often incidentally diagnosed during exploratory laparotomy or laparoscopy.We report a rare case of acute calculous cholecystitis with gallbladder hydrops (measuring 17 cm in maximum dimension) due to the obstruction of the cystic duct by a gallstone in a 67-year-old female.We highlight the importance of early magnetic resonance imaging (mri) in patients with right upper quadrant (ruq) pain to rule out gallbladder hydrops especially in those with a history of gallstones.

Journal: Cureus (2022)
Publication types: Case Reports;Journal Article
Ferrihydrite nanoparticles entrapped in shear-induced multilamellar vesicles.

Hypothesis ferrihydrite (fh) nanoparticles are receiving considerable scientific interest due to their large reactive surface areas, crystalline structures, and nanoparticle morphology.They are of great importance in biogeochemical processes and have the ability to sequester hazardous and toxic substances.Here, the working hypothesis was to entrap fractal-like fh nanoparticles, with a radius of gyration of 6.2 nm and a primary building block of polydisperse spheres with a radius of 0.8 nm, in a shear-induced multilamellar vesicle (mlv) state using a 40 wt% polyethylene glycol dodecyl ether surfactant.Experiments small- and wide- angle x-ray scattering revealed the equilibrium state of the non-ionic planar lamellar phase, the fh dispersion, and their mixture.The mlv state was induced by using a shear flow in a taylor-couette geometry of a rheometer.Findings the nonionic surfactant initially exhibited a lamellar gel phase with two distinct d-spacings of 11.0 and 9.7 nm, which collapsed into the mlv state under shear flow.The fh nanoparticles induced bilayer attraction by suppressing lamellar layer undulations, decreasing the d-spacing.These results are helpful in the understanding of the relationship between nanoparticle size and nanoparticle-bilayers interactions and provides insight on fh encapsulations in a kinetically stable mlvs state.

Journal: Journal of colloid and interface science (2022)
Publication types: Journal Article
Decrease in prevalence but increase in frequency of non-marijuana drug use following the onset of the COVID-19 pandemic in a large cohort of young men who have sex with men and young transgender women.

Substantial concern exists regarding the impact of the covid-19 pandemic on substance use behaviors.This is especially true for subpopulations like young men who have sex with men and young transgender women (ymsm-ytw) who report higher rates of substance use.This study examines changes in prevalence and frequency of marijuana and non-marijuana drug use among ymsm-ytw following the onset of the pandemic.Method data for this analysis (n = 458 participants, 1356 observations) come from an ongoing longitudinal cohort study of ymsm-ytw.A series of bayesian multilevel models were used to examine change in prevalence and frequency of use for marijuana and non-marijuana drugs.Results results indicated no systematic change in prevalence or frequency of marijuana use.However, a decrease in non-marijuana drug use was observed (or = 0.60, 95 % cr i: [0.37, 0.94]) following the onset of the pandemic.Furthermore, a small increase in the frequency of non-marijuana drug use was observed (or = 1.79, 95 % cr i: [1.02, 3.21]) among individuals who used these substances.Conclusions these findings concur with a small number of studies identifying a decrease in drug use prevalence but increase in frequency among those who continue to use drugs.Despite the protective effect of lower drug use prevalence, higher frequency of use may lead to additional negative health outcomes of drug use, particularly among groups facing multiple health challenges such as ymsm-ytw.However, the pandemic likely has a unique impact on substance use behaviors across subpopulations.

Journal: Drug and alcohol dependence (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Ultra high-resolution biomechanics suggest that substructures within insect mechanosensors decisively affect their sensitivity.

Insect load sensors, called campaniform sensilla (cs), measure strain changes within the cuticle of appendages.This mechanotransduction provides the neuromuscular system with feedback for posture and locomotion.Owing to their diverse morphology and arrangement, cs can encode different strain directions.We used nano-computed tomography and finite-element analysis to investigate how different cs morphologies within one location-the femoral cs field of the leg in the fruit fly drosophila-interact under load.By investigating the influence of cs substructures' material properties during simulated limb displacement with naturalistic forces, we could show that cs substructures (i.e.Socket and collar) influence strain distribution throughout the whole cs field.Altered socket and collar elastic moduli resulted in 5% relative differences in displacement, and the artificial removal of all sockets caused differences greater than 20% in cap displacement.Apparently, cs sockets support the distribution of distal strain to more proximal cs, while collars alter cs displacement more locally.Harder sockets can increase or decrease cs displacement depending on sensor location.Furthermore, high-resolution imaging revealed that sockets are interconnected in subcuticular rows.In summary, the sensitivity of individual cs is dependent on the configuration of other cs and their substructures.

Journal: Journal of the Royal Society, Interface (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Role of N-Methyl-D-Aspartate Receptor NR2B Subunit in Inflammatory Arthritis-Induced Chronic Pain and Peripheral Sensitized Neuropathic Pain: A Systematic Review.

Arthritis is a common clinical disease that affects millions of people in the world.The most common types of arthritis are osteoarthritis and rheumatoid arthritis.Inflammatory arthritis (ia), a chronic painful disease, is characterized by synovitis and cartilage destruction in the early stages.Pathologically, ia causes inflammatory changes in the joints and eventually leads to joint destruction.Pain is associated with inflammation and abnormal regulation of the nervous system pathways involved in pain promotion and inhibition.In addition, the occurrence of pain is associated with depression and anxiety.We found that there are many factors affecting pain, in addition to inflammatory factors, glutamate receptor may be the possible cause of long-term chronic pain caused by ia.N-methyl-d-aspartate receptor subunit 2b (nr2b) has been reported to involved in ia and nervous system diseases, especially peripheral neuropathic pain.In this review, we summarized the mechanisms of the nr2b subunit of the n-methyl-d-aspartate (nmda) receptor in peripheral nerve sensitization during ia and chronic pain.

Journal: Journal of pain research (2022)
Publication types: Journal Article;Review
A Clinician-Led, Experience-Based Co-Design Approach for Developing mHealth Services to Support the Patient Self-management of Chronic Conditions: Development Study and Design Case.

Despite the increasing use of mobile health (m health) services, such as m health apps or sms text messaging services, that support the patient self-management of chronic conditions, many existing m health services lack theoretical guidance.In addition, although often the target audience for requirement acquisition at the initial m health app design stage, it is a common challenge for them to fully conceptualize their needs for m health services that help self-manage chronic conditions.Objective this study proposes a novel co-design approach with the initial requirements for m health services proposed by clinicians based on their experiences in guiding patients to self-manage chronic conditions.A design case is presented to illustrate our innovative approach to designing an m health app that supports the self-management of patients with obesity in their preparation for elective surgery.Methods we adopted a clinician-led co-design approach.The co-design approach consisted of the following four cyclic phases: understanding user needs, identifying an applicable underlying theory, integrating the theory into the prototype design, and evaluating and refining the prototype m health services with patients.Expert panel discussions, a literature review, intervention mapping, and patient focus group discussions were conducted in these four phases.Results in stage 1, the expert panel proposed the following three common user needs: motivational, educational, and supportive needs.In stage 2, the team selected the social cognitive theory to guide the app design.In stage 3, the team designed and developed the key functions of the m health app, including automatic push notifications; web-based resources; goal setting and monitoring; and interactive health-related exchanges that encourage physical activity, healthy eating, psychological preparation, and a positive outlook for elective surgery.Push notifications were designed in response to a patient's risk level, as informed by the person's response to a baseline health survey.In stage 4, the prototype m health app was used to capture further requirements from patients in the two focus group discussions.Focus group participants affirmed the potential benefits of the app and suggested more requirements for the function, presentation, and personalization needs.The app was improved based on these suggestions.Conclusions this study reports an innovative co-design approach that was used to leverage the clinical experiences of clinicians to produce the initial prototype app and the approach taken to allow patients to effectively voice their needs and expectations for the m health app in a focus group discussion.This approach can be generalized to the design of any m health service that aims to support the patient self-management of chronic conditions.

Journal: JMIR mHealth and uHealth (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't