syedzayyan/paper_mill_benchmark huggingface dataset:
Correlation of CT radiomic features for GISTs with pathological classification and molecular subtypes: preliminary and monocentric experience.

Our primary purpose was to search for computed tomography (ct) radiomic features of gastrointestinal stromal tumors (gists) that could potentially correlate with the risk class according to the miettinen classification.Subsequently, assess the existence of features with possible predictive value in differentiating responder from non-responder patients to first-line therapy with imatinib.Methods a retrospective study design was carried out using data from june 2009 to december 2020.We analyzed all the preoperative cts of patients undergoing surgery for gists.We segmented non-contrast-enhanced ct (ncect) and contrast-enhanced venous ct (cect) images obtained either on three different ct scans (heterogeneous cohort) or on a single ct scan (homogeneous cohort).We then divided the patients into two groups according to miettinen classification criteria and based on the predictive value of response to first-line therapy with imatinib.Results we examined 54 patients with pathological confirmation of gists.For the heterogeneous cohort, we found a statistically significant relationship between 57 radiomic features for ncect and 56 radiomic features for cect using the miettinen risk classification.In the homogeneous cohort, we found the same relationship between 8 features for the ncect and 5 features for cect, all included in the heterogeneous cohort.The various radiomic features are distributed with different values in the two risk stratification groups according to the miettinen classification.We also found some features for groups predictive of response to first-line therapy with imatinib.Conclusions we found radiomic features that correlate with statistical significance for both the miettinen risk classification and the molecular subtypes of response.All features found in the homogeneous study cohort were also found in the heterogeneous cohort.Ct radiomic features may be useful in assessing the risk class and prognosis of gists.

Journal: La Radiologia medica (2022)
Publication types: Journal Article
ST2: Current status.

Cardiovascular diseases are leading cause of mortality and morbidity, and are responsible for 1 out of every 6 deaths in the united states.1cardiac remodeling is an important determinant of long term outcomes and occurrence of heart failure (hf).Many times one requires additional tools like biomarkers to identify high risk individuals, to diagnose disease conditions accurately and to effectively prognosticate the patients.St2 is a member of the interleukin 1 receptor family and exists in two forms, a trans-membrane receptor (st2l) as well as a soluble decoy receptor (s st2).2the ligand of st2 is interleukin-33 (il-33), which is involved in reducing fibrosis and hypertrophy in mechanically strained tissues.3.

Journal: Indian heart journal (2018)
Publication types: Journal Article;Review
The role of airborne transmission in a large single source outbreak of SARS-CoV-2 in a Belgian nursing home in 2020.

S to better understand the conditions which have led to one of the largest covid-19 outbreaks in belgian nursing homes in 2020.Setting a nursing home in flanders, belgium, which experienced a massive outbreak of covid-19 after a cultural event.An external volunteer who dressed as a legendary figure visited consecutively the 4 living units on december, 4th and tested positive for sars-co v-2 the next day.Within days, residents started to display symptoms and the outbreak spread rapidly within the nursing home.Methods we interviewed key informants and collected standardized data from all residents retrospectively.A batch of 115 positive samples with a ct value of < 37 by q rt-pcr were analyzed using whole-genome sequencing.Six months after the outbreak, ventilation assessment of gathering rooms in the nursing home was done using a tracer gas test with calibrated co2sensors.Results timeline of diagnoses and symptom onsets clearly pointed to the cultural event as the start of the outbreak, with the volunteer as index case.The genotyping of positive samples depicted the presence of one large cluster, suggesting a single source outbreak.By the end of december, a total of 127 residents and 40 staff were diagnosed with sars-co v-2 since the beginning of the outbreak.The attack rate among residents was 77 % and significantly associated with presence at the event but not with close contact or mask wearing.The ventilation assessment showed a high background average co2level in four main rooms varying from 657 ppm to 846 ppm.Conclusions our investigation shows a rapid and widespread single source outbreak of sars-co v-2 in a nursing home, in which airborne transmission was the most plausible explanation for the massive intra-facility spread.Our results underscore the importance of ventilation and air quality for the prevention of future outbreaks in closed facilities.

Journal: Epidemics (2022)
Publication types: Journal Article
Poststroke Grasp Ability Assessment Using an Intelligent Data Glove Based on Action Research Arm Test: Development, Algorithms, and Experiments.

Growing impact of poststroke upper extremity (ue) functional limitations entails newer dimensions in assessment methodologies.This has compelled researchers to think way beyond traditional stroke assessment scales during the out-patient rehabilitation phase.In concurrence with this, sensor-driven quantitative evaluation of poststroke ue functional limitations has become a fertile field of research.Here, we have emphasized an instrumented wearable for systematic monitoring of stroke patients with right-hemiparesis for evaluating their grasp abilities deploying intelligent algorithms.An instrumented glove housing 6 flex sensors, 3 force sensors, and a motion processing unit was developed to administer 19 activities of action research arm test (arat) while experimenting on 20 voluntarily participating subjects.After necessary signal conditioning, meaningful features were extracted, and subsequently the most appropriate ones were selected using the relief f algorithm.An optimally tuned support vector classifier was employed to classify patients with different degrees of disability and an accuracy of 92% was achieved supported by a high area under the receiver operating characteristic score.Furthermore, selected features could provide additional information that revealed the causes of grasp limitations.This would assist physicians in planning more effective poststroke rehabilitation strategies.Results of the one-way anova test conducted on actual and predicted arat scores of the subjects indicated remarkable prospects of the proposed glove-based method in poststroke grasp ability assessment and rehabilitation.

Journal: IEEE transactions on bio-medical engineering (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Inactivation of AUF1 in Myeloid Cells Protects From Allergic Airway and Tumor Infiltration and Impairs the Adenosine-Induced Polarization of Pro-Angiogenic Macrophages.

The four isoforms of the rna-binding protein hn rnpd/auf1 have been proposed to limit the use of inflammatory m rnas in innate immune cells.Mice engineered to lack auf1s in all tissues are sensitive to acute inflammatory assaults; however, they also manifest complex degenerations obscuring assessment of auf1s' roles in innate immune cells.Here, we restricted a debilitating auf1 mutation to the mouse myeloid lineage and performed disease-oriented phenotypic analyses to assess the requirement of auf1s in variable contexts of innate immune reactivity.Contrary to the whole-body mutants, the myeloid mutants of auf1s did not show differences in their susceptibility to cytokine storms occurring during endotoxemia; neither in type-i cell-mediated reactions driving intestinal inflammation by chemical irritants.Instead, they were resistant to allergic airway inflammation and displayed reductions in inflammatory infiltrates and an altered t-helper balance.Theex-vivoanalysis of macrophages revealed that the loss of auf1s had a minimal effect on their proinflammatory gene expression.Moreover, auf1s were dispensable for the classical polarization of cultured macrophages by lps & ifnγ correlating with the unchanged response of mutant mice to systemic and intestinal inflammation.Notably, auf1s were also dispensable for the alternative polarization of macrophages by il4, tgfβ and il10, known to be engaged in allergic reactions.In contrast, they were required to switch proinflammatory macrophages towards a pro-angiogenic phenotype induced by adenosine receptor signals.Congruent to this, the myeloid mutants of auf1 displayed lower levels of vascular remodeling factors in exudates from allergen exposed lungs; were unable to support the growth and inflammatory infiltration of transplanted melanoma tumors; and failed to vascularize inert grafts unless supplemented with angiogenic factors.Mechanistically, adenosine receptor signals enhanced the association of auf1s with the vegfa, il12b, and tnfm rnas to differentially regulate and facilitate the pro-angiogenic switch.Our data collectively demonstrates that auf1s do not act as general anti-inflammatory factors in innate immune cells but have more specialized roles in regulons allowing specific innate immune cell transitions to support tissue infiltration and remodeling processes.

Journal: Frontiers in immunology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
High Volume Liposuction in Tumescence Anesthesia in Lipedema Patients: A Retrospective Analysis.

Lipedema is a chronic, progressive disease that occurs almost exclusively in women and leads to pathological, painful fat growths at the extremities.Only symptomatic therapy can be offered since the etiology of the disease has not yet been clarified.Liposuction in tumescent anesthesia has established itself as a surgical treatment method of choice.The complication rate associated with the procedure and the pharmacological course and safety of treatment in patients with lipedema has not yet been sufficiently studied.The aim of the study was to broaden the evidence on the safety of ambulatory high-volume liposuction in tumescent anesthesia in lipedema patients.Influencing factors of patients (weight, fat content, comorbidities) or the process technique (drug administration, volume of aspirates) should be investigated on the safety and risks of tumescent anesthesia.This was a retrospective data analysis in which data from 27 patients (40 liposuction procedures) treated at the sandhofer and barsch lipedema center between 2016 and 2018 were evaluated.The liposuctions were carried out in tumescent anesthesia and using a power-assisted liposuction system.Clinical examinations and regular blood samples were carried out before the procedure, intra- and postoperatively.The procedures lasted an average of 118 minutes and an average of 6111 ml of aspirate was removed.For tumescent anesthesia, patients were given an average lidocaine dose of 34.23 mg/kg body weight and an epinephrine dose of 0.11 mg/kg body weight.No relevant complications associated with drug side effects, hypovolemia or hypervolemia or blood loss were detected.Liposuction under high volume tumescent anesthesia for the treatment of lipedema patients is, even for major intervention, a safe procedure.J drugs dermatol.2021;20(3):326-334.

Journal: Journal of drugs in dermatology : JDD (2021)
Publication types: Journal Article
Valence Photoelectron Spectra of Liquid Methanol and Ethanol Measured Using He II Radiation.

High-resolution photoelectron (pe) spectra of liquid methanol and ethanol were measured using a liquid microjet and he iiα radiation (40.813 e v).The vertical ionization energy and the ionization threshold were determined as 9.70 ± 0.07 and 8.69 ± 0.07 e v for methanol and 9.52 ± 0.07 and 8.52 ± 0.07 e v for ethanol, respectively.Individual photoemission bands observed for the liquids are well correlated with those in pe spectra of the gaseous samples also measured in the present study, except that the liquid band positions were shifted on average by -1.23 e v for methanol and -1.10 e v for ethanol as compared to the gas.The 5a' and 7a' bands of liquid methanol exhibit specifically larger broadening than other bands, for which we attempted spectral fitting with two components, similarly with the case of the 3a1band of liquid water.Pe spectra of both liquid and gaseous ethanol are congested partly due to the presence of thetransandgaucheisomers; however, the overall band positions are generally in good agreement with predictions based on quantum chemical calculations.Comparison of the measured pe spectra with experimental and simulated x-ray emission spectra indicate that spectral differences in the lowest ionization band of both methanol and ethanol originate from involvement of nuclear dynamics in the x-ray emission process.

Journal: The journal of physical chemistry. A (2021)
Publication types: Journal Article
Suprachoroidal Space Triamcinolone Acetonide: A Review in Uveitic Macular Edema.

Triamcinolone acetonide injectable suspension for suprachoroidal use (xipere®; scs triamcinolone acetonide) is a corticosteroid approved in the usa for the treatment of macular edema associated with uveitis.Suprachoroidal injection of scs triamcinolone acetonide results in preferential distribution into the posterior segment, which may reduce the risk of corticosteroid-related adverse events, such as cataracts and intraocular pressure (iop) elevation.In a multicenter phase iii trial in patients with non-infectious uveitic macular edema, scs triamcinolone acetonide significantly and rapidly improved visual acuity and reduced signs of macular edema compared with sham treatment.Scs triamcinolone acetonide was generally well tolerated, with the most common adverse event being eye pain on the day of the procedure.The risk of corticosteroid-related iop elevation appeared to be reduced in unrescued patients in the scs triamcinolone acetonide group compared with patients in the sham control group who received rescue therapy.Scs triamcinolone acetonide is a novel and useful treatment option for uveitic macular edema.

Journal: Drugs (2022)
Publication types: Journal Article;Review
Copper-Catalyzed 3-Positional Amination of 2-Azulenols withO-Benzoylhydroxylamines.

A copper-catalyzedortho-selective amination of 2-azulenols with o-benzoylhydroxylamines (rr'n-obz) to synthesizeortho-aminoazulenols is reported.A wide range of functional groups on amines are compatible, furnishing the corresponding amino-azulene derivatives in moderate to good yields.The further synthetic elaboration using 3-amino-2-azulenols as starting materials is demonstrated.

Journal: Organic letters (2021)
Publication types: Journal Article
Autistic children's age difference in affiliate stigma and resilience of their parents in China: A cross-sectional study.

Parents of children with autism spectrum disorders (asd) experience high levels of stigma, especially in china where the culture is shame socialized.Resilience can help overcome stigma; while parent characteristics predict resilience, other factors may also be significant such as the child's age.Objective the study sought to identify the differences in affiliate stigma and resilience among chinese parents of children with asd according to the child's age, and to determine whether the levels of resilience and experience of stigma are related.Methods a cross-sectional survey of 184 parents of children with asd was conducted.Affiliate stigma and resilience were measured using the chinese version of the 22-item affiliate stigma scale and the chinese version of the connor-davidson resilience scale.Differences were examined by using regression and correlation analysis.Results parents of school-age children experienced more affiliate stigma than parents of preschoolers, but there was no difference in resilience when other factors were controlled.Conclusions considering the child's age is important to understand affiliate stigma and resilience, particularly where resilience is protective and could inform the design of support strategies for preschooler parents.

Journal: Archives of psychiatric nursing (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Fast-Growing Bacterial Cellulose with Outstanding Mechanical Properties via Cross-Linking by Multivalent Ions.

Bacterial cellulose is an organic product of certain bacterias' metabolism.It differs from plant cellulose by exhibiting a high strength and purity, making it especially interesting for flexible electronics, membranes for water purification, tissue engineering for humans or even as artificial skin and ligaments for robotic devices.However, bacterial cellulose's naturally slow growth rate has limited its large-scale applicability to date.Titanium (iv) bis-(ammonium lactato) dihydroxide is shown to be a powerful tool to boost the growth rate of bacterial cellulose production by more than one order of magnitude and that it simultaneously serves as a precursor for the ti4+-coordinated cross-linking of the fibers during membrane formation.The latter results in an almost two-fold increase in young's modulus (~18.59 gpa), a more than three-fold increase in tensile strength (~436.70 mpa) and even a four-fold increase in toughness (~6.81 mj m-3), as compared to the pure bacterial cellulose membranes.

Journal: Materials (Basel, Switzerland) (2020)
Publication types: Journal Article
Mechanism and Prediction of Hydrogen Embrittlement in fcc Stainless Steels and High Entropy Alloys.

The urgent need for clean energy coupled with the exceptional promise of hydrogen (h) as a clean fuel is driving development of new metals resistant to hydrogen embrittlement.Experiments on new fcc high entropy alloys present a paradox: these alloys absorb more h than ni or ss304 (austenitic 304 stainless steel) while being more resistant to embrittlement.Here, a new theory of embrittlement in fcc metals is presented based on the role of h in driving an intrinsic ductile-to-brittle transition at a crack tip.The theory quantitatively predicts the h concentration at which a transition to embrittlement occurs in good agreement with experiments for ss304, ss316l, co cr ni, co ni v, co cr fe ni, and co cr fe mn ni.The theory rationalizes why co ni v is the alloy most resistant to embrittlement and why ss316l is more resistant than the high entropy alloys co cr fe ni and co cr fe mn ni, which opens a path for the computationally guided discovery of new embrittlement-resistant alloys.

Journal: Physical review letters (2021)
Publication types: Journal Article
Ameliorative Effect of Kiwifruit (Actinidia deliciosa) against Lead-Induced Oxidative Stress in Wistar Albino Rats.

&lt;b&gt;background and objective:&lt;/b&gt; lead is defined as a severe adverse metal that induces neurological, renal, haematological and hepatic dysfunctions.It stimulates oxidative stress to disrupt the antioxidative enzyme mechanism, organ structure and lipid membranes of the cell.Kiwifruit (&lt;i&gt;actinidia deliciosa&lt;/i&gt;) is amongst the world's most valuable fruits due to its various pharmacological characteristics and health benefits.The present research was intended to observe the antioxidant efficiency of kiwifruit ethanolic extract on lead toxicity in the hepatic, renal, brain and blood tissues in rats.&lt;b&gt;materials and methods:&lt;/b&gt; twenty-four adult wister albino rats were classified into 4 groups with 6 rats within each group.The rats in group i functioned as normal control.Animals within group ii, iii and iv were given three intraperitoneal doses of lead acetate (25 mg kg&lt;sup&gt;1&lt;/sup&gt; b.wt., liquefied in distilled h&lt;sub&gt;2&lt;/sub&gt;o as a vehicle) on the day 7th, 14th and 21st of the experiment.Group iii and iv were the treatment groups and were treated with a daily oral dose of kiwifruit extract (250 and 500 mg kg&lt;sup&gt;1&lt;/sup&gt; b.wt., respectively) for 28 days.&lt;b&gt;results:&lt;/b&gt; the protective impact of kiwifruit was observed in the improvement in antioxidant enzyme activity [catalase (cat), superoxide dismutase (sod), glutathione peroxidase (gpx) and glutathione reductase (gr)] and decreased level of lipid peroxidation (lpo) in the liver, brain and kidney tissues.Additionally, &lt;i&gt;actinidia deliciosa&lt;/i&gt; has a great effect on increasing acetylcholine esterase activity in the brain and also, improved the delta-aminolevulinic acid dehydratase activity in the blood.&lt;b&gt;conclusion:&lt;/b&gt; kiwifruit emerged as an effective factor for the alleviation of lead-induced oxidative damage in cells.

Journal: Pakistan journal of biological sciences : PJBS (2021)
Publication types: Journal Article
Beyond EGFR, ALK and ROS1: Current evidence and future perspectives on newly targetable oncogenic drivers in lung adenocarcinoma.

Lung cancer is the leading cause of cancer death worldwide.In the past decade egfr, alk and ros1 tkis lead to an unprecedented survival improvement of oncogene-addicted nsclc patients, with better toxicity profile compared to chemotherapy.In recent years the implementation of high-throughput sequencing platforms led to the identification of uncommon molecular alterations in oncogenic drivers, such as braf, met, ret, her2 and ntrk.Moreover, newly developed drugs have been found to be active against hard to target drivers, such as kras.Specific tkis targeting these genomic alterations are currently in clinical development and showed impressive activity and survival improvement, leading to fda-accelerated approval for some of them.However, virtually all patients develop resistance to tkis by on-target or off-target mechanisms.Here we review the clinicopathological features, the emerging targeted therapies and mechanisms of resistance and strategies to overcome them of kras, braf, met, ret, her2 and ntrk-addicted advanced nsclcs.

Journal: Critical reviews in oncology/hematology (2020)
Publication types: Journal Article;Review
Is it enough for COVID-19 screening test? Limitation of swab test and general characteristics of mild symptom patients.

The most common method for sars-co v-2 testing is throat or nasal swabbing by real-time reverse transcription polymerase chain reaction (rt-pcr) assay.In south korea, drive-through swab test is used for screening system and community treatment centers (ctcs), which admit and treat confirmed covid-19 patients with mild symptoms, are being used.This retrospective study was conducted on patients admitted to a ctc on march 6, 2020.A total of 313 patients were admitted.The nasal and throat swabs were collected from the upper respiratory tract, and a sputum test was performed to obtain lower respiratory samples.The positive rate of the first set of test, sputum test was higher than that of the swab test (p= 0.011).In the second set of test, 1 week after the first ones, the rate of positive swab tests was relatively high (p= 0.026).In the first set of test, 66 of 152 (43.4%) patients showed 24-h consecutive negative swab test results, when the sputum test results were considered together, that number fell to 29 patients (19.1%) (p< 0.001).Also, in the second set of test, 63 of 164 (38.4%) patients met the discharge criteria only when the swab test was considered; that number fell to 30 (18.3%) when the sputum test results were also considered (p< 0.001).Using the swab test alone is insufficient for screening test and discharge decision.Patients who may have positive result in the sputum test can be missed.

Journal: Science progress (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't