syedzayyan/paper_mill_benchmark huggingface dataset:
Identification of Meaningful Data for Providing Real-Time Intraoperative Feedback in Laparoscopic Surgery Using Delphi Analysis.

Surgeons are at risk of being overwhelmed with information while performing surgery.Initiatives focusing on the use of medical data in the operating room are on the rise.Currently, these initiatives require postprocessing of data.Although highly informative, data cannot be used to influence preventable error in real time.Ideally, feedback is provided preemptive.aims.First, to identify which information is considered to be relevant for real-time feedback during laparoscopic surgery according to surgeons.Second, to identify the optimal routing for providing such feedback, and third, to decide on optimal timing for feedback to alarm users during laparoscopic surgery.methods.A delphi study of 3 iterations was conducted within the amsterdam umc, location amc.A total of 25 surgeons and surgical residents performing laparoscopy were surveyed using 5-point likert scales.Consensus was obtained when 80% of answers fitted the same answering category.results.Delphi round 1 resulted in 198 unique ideas within 5 scenarios.After round 3, consensus was obtained on 102 items.Feedback most relevant during laparoscopic surgery refers to equipment like the gas insufflator, diathermy, and suction device.Feedback should be delivered via an additional monitor.Surgeons want to be instantly alarmed about aberrations in patients' vital parameters or combinations of vital parameters, preferably via a designated section on a monitor in their field of vision.conclusions.surgeons performing laparoscopy are uniform in their opinion that they need to be alarmed immediately when patients' vital parameters are becoming aberrant.Surgeons state that information regarding supporting equipment is best displayed on an additional monitor.

Journal: Surgical innovation (2021)
Publication types: Journal Article
Effect of scanner lens on lateral response artefact in radiochromic film dosimetry.

Radiochromic film is a good dosimeter choice for patient qa for complex treatment techniques because of its near tissue equivalency, high spatial resolution and established method of use.Commercial scanners are typically used for film dosimetry, with epson scanners being the most common.Radiochromic film dosimetry is not straightforward having some well-defined problems which must be considered, one of the main ones being the lateral response artefact (lra) effect.Previous studies showed that the contributing factors to lra are from the structure of the active ingredients of the film and the components and construction of the flatbed scanner.This study investigated the effect of the scanner lens on the lra effect, as part of a wider investigation of scanner design effects and uncertainties.Gafchromic ebt3 films were irradiated with 40 × 40 cm2field size 6 mv beams.Films were analysed using images captured by a canon 7d camera utilising 18 mm, 50 mm and 100 mm focal length lenses compared to images scanned with a conventional epson v700 scanner.The magnitude of the lra was observed to be dependent on the focal length of the lens used to image the film.A substantial reduction in lra was seen with the use of the 50 mm and 100 mm lenses, by factors of 3-5 for the 50 mm lens and 4-30 for the 100 mm lens compared to conventional desktop scanner techniques.This is expected to be from the longer focal length camera lens system being able to collect more light from distant areas compared to the scanner-based system.This provides an opportunity to design film dosimetry systems that minimise this artefact.

Journal: Physical and engineering sciences in medicine (2022)
Publication types: Journal Article
A novel compound heterozygous variant linked to hematuria in a family with hereditary factor VII deficiency.

Hereditary factor vii deficiency (fviid) is a rare congenital autosomal recessive bleeding disorder.In clinical manifestations, its onset is caused by variant of the f7 gene (nm_019616) with strong heterogeneity.We identified a family with hematuria caused by a novel f7 compound heterozygous variant and investigated the fviid-dependent mechanism impacted by these variants.Methods coagulation factors in the proband were functionally verified.We located pathogenic variants in relevant genes using next-generation sequencing after target enrichment and verified them by sanger sequencing.We examined the coagulation activity and secretion pattern of recombinant fvii variants expressed in cells and observed their location and stability by immunofluorescence.Results we found a missense variant c.1207g>a (p.gly403ser) and a frameshift variant c.154_155del (p.arg53fs) in the f7 gene of the proband.Fvii activity tests showed that the variants significantly decreased its presence in the cell culture supernatant.Moreover, the r53fs mutant lacked the fvii functional domain and had no detectable activity.Immunofluorescence indicated that the p.gly403ser variant was distributed to the cell membrane and cytoplasm, whereas the fvii r53fs variant was not detected.Deficient fvii protein function and severe coagulation disorder are the likely causes of hematuria and other bleeding symptoms in the proband.Conclusions the newly discovered f7 gene variants enrich the spectrum of hereditary fvii deficiency and provide a new foundation for the diagnosis and treatment of this type of coagulation disorder.

Journal: The journal of gene medicine (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Designing antimicrobial biomembranes via clustering amino-modified cellulose nanocrystals on silk fibroin β-sheets.

The continuous rising of infections caused by multidrug-resistant pathogens is becoming a global healthcare concern.Developing new bio-based materials with unique chemical and structural features that allow efficient interaction with bacteria is thus important for fighting this phenomenon.To address this issue, we report an antimicrobial biomaterial that results from clustering local facial amphiphilicity from amino-modified cellulose on silk fibroin β-sheets, by simply blending the two components through casting technology.A simple but effective method for creating a membrane that is antibacterial and non-cytotoxic.Amino-modified cellulose nanocrystals (cnc-nh2) were mixed with proteinaceous silk fibroin (sf) which resulted in a material with improved crystallinity, higher β-sheet content, and exposed amino-groups at its surface features, proven by fourier transform infrared (ftir) spectroscopy and x-ray photoelectron spectroscopy (xps), that does not occur when the components are individually assembled.The resulting material possesses important antibacterial activity inducing >3 cfu log10reduction of escherichia coli and staphylococcus epidermidis, while the pristine membranes show no antibacterial effect.The chemical interactions occurring between sf and cnc-nh2during casting, exposing the amino moieties at the surface of the material, are proposed as the main reason for this antimicrobial activity.Importantly, the membranes are non-cytotoxic, showing their potential to be used as a new bioinspired material with intrinsic antibacterial activity for biomedical applications.Those may include coatings for medical devices for the control of healthcare-associated infections, with no need for including external antimicrobial agents in the material.

Journal: International journal of biological macromolecules (2023)
Publication types: Journal Article
Concentration, Distribution and Biomagnification of Novel Brominated Flame Retardant in Grassland Food Chain and Sheep from Inner Mongolia, China.

Novel brominated flame retardants (nbfrs) have been of great concern in the past few years due to their ubiquity in the environment and potential bioconcentration characteristics.This study takes xilingol grassland in inner mongolia as the research area to analyze the pollution characteristics of nbfrs (p tbx, hbb, pbt, pbbz, and pbeb) in the grassland food chain.P tbx was more likely to be biomagnified in the food chain of amphibians, reptiles, and birds, whereas pbt and hbb were more likely to be biomagnified in the food chain of mammals.This may be because these animals have different diets and metabolic patterns.According to the concentration distribution of nbfrs in sheep organs and tissues, pbt, hbb, and pbbz easy bioaccumulated in sheep.The biomagnification effect of sheep adipose tissue and internal organs on nbfrs was inconsistent, so the biomagnification of chemicals in organisms cannot be determined only by the biomagnification of adipose tissue.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Metagenomic analysis of gut microbiota in non-treated plaque psoriasis patients stratified by disease severity: development of a new Psoriasis-Microbiome Index.

Psoriasis is an immune-mediated skin disorder.Imbalance of gut microbial populations has been implicated in many diseases.We aimed to investigate whether there were differences in gut microbiota in psoriasis patients vs non-psoriasis controls and between psoriasis severity groups.55 psoriasis patients and 27 controls were included.V3-v4 regions of the 16s r rna gene of fecal samples were analyzed using illumina mi seq.Bioinformatic analysis was performed.We found changes in gut microbiome composition depending on their psoriasis status as determined by weighted unifrac (p 2).Moderate-to-severe psoriasis patients had lower biodiversity than mild psoriatic patients (p = 0.049).No differences for beta-diversity were found.We developed a psoriasis-microbiota index (pmi), which discriminated among psoriasis patients and controls with sensitivity: 0.78 and specificity: 0.79.Furthermore, we performed a meta-analysis with published data to validate this index.We demonstrated gut dysbiosis in psoriasis patients, suggesting a role in psoriasis pathophysiology.Furthermore, we developed a pmi with the potential to discriminate between psoriasis patients and controls across different populations, which could be used as a biomarker in the clinical practice.

Journal: Scientific reports (2020)
Publication types: Journal Article;Meta-Analysis;Research Support, Non-U.S. Gov't
Thermal self-regulatory intelligent biosensor based on carbon-nanotubes-decorated phase-change microcapsules for enhancement of glucose detection.

Enzyme-based biosensors are sensitive to temperature due to their strong temperature dependency of catalytic activity.Aiming at enhancing biosensing detection for glucose assay over a wide range of applicable temperatures, we designed a thermal self-regulatory intelligent biosensor through an innovative integration of phase change material (pcm) and bioelectrocatalytic substances.An electroactive phase-change microcapsule system was firstly fabricated by microencapsulating n-docosane as a pcm core in the si o2shell, followed by depositing polydopamine along with carbon nanotubes as an electroactive layer on the surface of si o2shell.The resultant microcapsules showed a regularly spherical morphology and well-defined core-shell microstructure.They also exhibited a satisfactory latent heat capacity of around 137 j/g for implementing temperature regulation with a good working stability.An electrochemical biosensing system was constructed with the resultant electroactive microcapsules together with glucose oxidase as a redox enzyme, achieving a thermal self-regulation capability to enhance the biosensing detection of glucose under in-situ thermal management at higher temperatures.With a high sensitivity of 5.95 μa⋅m m-1⋅cm-2and a lower detection limit of 13.11 μm at 60 °c, the intelligent biosensor developed by this study demonstrated a superior determination capability and better detection performance toward glucose than conventional biosensors in a high temperature region thanks to effective regulation of microenvironment temperature in the electrode system.This study provides a promising strategy for the development of thermal self-regulatory smart biosensors with an enhanced identification ability to detect various chemical substances over a wide range of applicable temperatures.

Journal: Biosensors & bioelectronics (2022)
Publication types: Journal Article
Ocular Surface Disease Signs and Symptoms in Patients with Pseudoexfoliative Glaucoma: A Case-Control Study.

The present study evaluates the differences in the prevalence of the signs and symptoms of ocular surface disease (osd) in patients with pex glaucoma (pexg), compared to other glaucoma types (non-pexg).Methods patients with non-pexg and pexg were prospectively examined for the presence and severity of osd signs and questioned for symptoms using the osdi (ocular surface disease index) questionnaire.Results 116 patients were prospectively enrolled (58 non-pexg and 58 pexg).Pexg subjects who were older, had lower central corneal thickness (cct) values, at a more advanced glaucoma stage and required more iop lowering drops.Osd signs were prevalent in both groups: conjunctival hyperemia (74.5% non-pexg vs.94.8% pexg), eyelid redness (70.7% vs.96.6%), conjunctival (74.1% vs.93.1%) and corneal fluorescein staining (81% vs.93.1%) and abnormal tfbut (82.8% vs.87.9%).When adjusted for potential confounders, (older age, thinner cct, more advanced glaucoma in pexg) eyelid redness remained the only parameter significantly associated with pexg, being 11 times more likely to occur in this group (p= 0.037).Conclusion subjects with pexg presented a higher frequency of signs of osd compared to other glaucoma types.When accounting for confounding factors, the only difference between the groups was the significantly higher presence (11 times more likely) of eyelid redness in pexg, suggesting, in addition to glaucoma treatment, the impact of pex on ocular surface integrity.

Journal: Vision (Basel, Switzerland) (2022)
Publication types: Journal Article
Phytochemical Analysis and Antinociceptive Properties of Hydroalcoholic Extracts of Aleurites moluccanus Bark.

Aleurites moluccanusis used in folk medicine to treat many diseases including pain and inflammatory processes in general.Considering the potential of the leaf extract, evidenced in a previous study, the present study investigates the antinociceptive and anti-inflammatory properties of the hydroethanolic extract of a.Moluccanusbark and isolated compounds in animal models of pain.The antinociceptive and anti-inflammatory activities of a.Moluccanusbark were evaluated through hyperalgesia induced by carrageenan, pge2, cytokines, bradykinin, epinephrine, freund's complete adjuvant, and lipopolysaccharide.Five compounds were isolated from the dichloromethane bark extract: acetyl aleuritolic acid, atraric acid, spruceanol, (5β,10α)-12-hydroxy-13-methoxy-8,11,13-podocarpatrien-3-one and sonderianol.To optimize the extraction conditions, ethanol 50, 70, and 90°gl were used as extracting solvent, in a 1 : 20 (w/v) drug : solvent ratio, under stirring at room temperature for 4 h.The extracts were named amc50, amc70, and amc90, respectively.These extracts were administered to mice (250 mg/kg, p.O.) with reduced mechanical hyperalgesia activity in the carrageenan test.Of these, amc90 showed the best results.Pure (5β,10α)-12-hydroxy-13-methoxy-8,11,13-podocarpatrien-3-one showed a beneficial effect for up to 48 hours after the administration of carrageenan, while acetyl aleuritolic acid was effective only in the first hour.Amc90 was able to reverse the analgesia induced only by prostaglandin e2and tumor necrosis factor.We also induced hyperalgesia using the lipopolysaccharide and freund's complete adjuvant models, with positive results.These results support the antinociceptive and anti-inflammatory activity of a.Moluccanusbark extract.The observed effects are partly due to the presence of acetyl aleuritolic acid, atraric acid, and (5β,10α)-12-hydroxy-13-methoxy-8,11,13-podocarpatrien-3-one.

Journal: Planta medica (2021)
Publication types: Journal Article
Clinical course of patients with aspirin-exacerbated respiratory disease: can we predict the prognosis?

This study aimed to identify prognostic factors of aspirin-exacerbated respiratory disease by comparing clinical and genetic data with the clinical course.Patients & methods patients were classified into two groups according to their response to inhalation rechallenge with lysine-aspirin after at least 1 year of regular treatment with antiasthmatic medications.Results forty eight patients (39.3%, group i) had negative responses, whereas 74 patients (60.7%, group ii) had positive responses (n = 23) or were not rechallenged owing to persistent symptoms (n = 51).Fev1 at diagnosis and follow-up were significantly lower in group ii than in group i.The ccr3 polymorphism at -520t/g differed significantly between the two groups, whereas no difference was found in other snps.Conclusion baseline fev1 and lower lung function after treatment were clinical factors indicating a poor prognosis of aspirin-exacerbated respiratory disease.The g allele of ccr3 -520t>g was associated with persistent bronchial hypersensitivity to aspirin.

Journal: Pharmacogenomics (2014)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Patient journey in erosive oesophagitis: real-world perspectives from US physicians and patients.

Management of erosive oesophagitis (ee) remains suboptimal, with many patients experiencing incomplete healing, ongoing symptoms, and relapse despite proton pump inhibitor (ppi) treatment.The study of acid-related disorders investigated patient burden of individuals with ee in a real-world setting.Design us gastroenterologists (gis) or family physicians (fps)/general practitioners (gps) treating patients with ee completed a physician survey and enrolled up to four patients with ee for a patient survey, with prespecified data extracted from medical records.Results 102 gis and 149 fps/gps completed the survey; data were available for 73 patients (mean age at diagnosis, 45.4 years).Omeprazole was healthcare professional (hcp)-preferred first-line treatment (60.8% gis; 56.4% fps/gps), and pantoprazole preferred second line (29.4% and 32.9%, respectively).Price and insurance coverage (both 55.5% hcps) and familiarity (47.9%) key drivers for omeprazole; insurance coverage (52.0%), price (50.0%), familiarity (48.0%), initial symptom relief (46.0%), and safety (44.0%) key drivers for pantoprazole.Only 49.3% patients took medication as instructed all the time; 56.8% independently increased medication frequency some of the time.Despite treatment, 57.5% patients experienced heartburn and 30.1% regurgitation; heartburn was the most bothersome symptom.58.9% patients believed that their symptoms could be better controlled; only 28.3% hcps were very satisfied with current treatment options.83.6% patients wanted long-lasting treatment options.Fast symptom relief for patients was a top priority for 66.1% hcps, while 56.6% would welcome alternatives to ppis.Conclusion this real-world multicentre study highlights the need for new, rapidly acting treatments in ee that reduce symptom burden, offer durable healing and provide symptom control.

Journal: BMJ open gastroenterology (2022)
Publication types: Journal Article;Multicenter Study;Research Support, Non-U.S. Gov't
The effects of SCFAs on glycemic control in humans: a systematic review and meta-analysis.

Noncommunicable disease development is related to impairments in glycemic and insulinemic responses, which can be modulated by fiber intake.Fiber's beneficial effects upon metabolic health can be partially attributed to the production of scfas via microbial fermentation of fiber in the gastrointestinal tract.Objectives we aimed to determine the effects of scfas, acetate, propionate, and butyrate on glycemic control in humans.Methods the central, embase, pub med, scopus, and web of science databases were searched from inception to 7 december 2021.Papers were included if they reported a randomized controlled trial measuring glucose and/or insulin compared to a placebo in adults.Studies were categorized by the type of scfa and intervention duration.Random-effects meta-analyses were performed for glucose and insulin for those subject categories with ≥3 studies, or a narrative review was performed.Results we identified 43 eligible papers, with 46 studies within those records (n = 913), and 44 studies were included in the meta-analysis.Vinegar intake decreased the acute glucose response [standard mean difference (smd), -0.53; 95% ci, -0.92 to -0.14; n = 67] in individuals with impaired glucose tolerance or type 2 diabetes and in healthy volunteers (smd, -0.27; 95% ci, -0.54 to 0.00; n = 186).The meta-analyses for acute acetate, as well as acute and chronic propionate studies, showed no significant effect.Conclusions vinegar decreased the glucose response acutely in healthy and metabolically unhealthy individuals.Acetate, propionate, butyrate, and mixed scfas had no effect on blood glucose and insulin in humans.Significant heterogeneity, risks of bias, and publication biases were identified in several study categories, including the acute vinegar glucose response.As evidence was very uncertain, caution is urged when interpreting these results.Further high-quality research is required to determine the effects of scfas on glycemic control.

Journal: The American journal of clinical nutrition (2022)
Publication types: Journal Article;Meta-Analysis;Systematic Review
Acute physiological responses with varying load or time under tension during a squat exercise: A randomized cross-over design.

S despite advancements in resistance training (rt) methods, the acute metabolic and neuromuscular responses to time under tension (tut) and load remains poorly understood.The aim of the present study was to investigate how tut or resistance load impact muscular activation and blood lactate during an rt session.Design a randomized cross-over design.Methods participants performed a squat exercise in three different conditions: baseline protocol (bpro; three sets of eight repetitions with four second repetitions at 60% of 1rm) long duration protocol (ldpro: six second repetitions) and high load protocol (hlpro: 70% 1rm).Results muscular activation of the vastus lateralis and biceps femoris, and blood lactate were assessed.Blood lactate was ∼19% and ∼26% higher after set one and three in ldprocompared to bpro(p≤0.011) and ∼17% higher for ldprocompared to hlpro(p=0.002).Additionally, blood lactate was ∼17% higher for hlprocompared to bproafter the third set of exercise (p=0.003).Vastus lateralis activation was ∼10% higher for hlprocompared to bproand ldprofor sets one and two.Biceps femoris activation was ∼17% higher for hlprocompared to bprofor set one (p= 0.023) while for set two hlprowas greater than bproand ldpro(∼19% and ∼14%, respectively; p≤0.007).Conclusions squatting with higher tut caused a greater impact on the metabolic responses than lower tut or higher loads, whereas an increase in training load resulted in greater muscle activation than higher tut or lower training load.

Journal: Journal of science and medicine in sport (2021)
Publication types: Journal Article;Randomized Controlled Trial