syedzayyan/paper_mill_benchmark huggingface dataset:
Donor-recipient predicted heart mass ratio and right ventricular-pulmonary arterial coupling in heart transplant.

S right ventricular-pulmonary arterial (rv-pa) coupling interactions are largely unexplored in heart transplant patients.The outcome of this study was rv-pa coupling at 7 and 30 days after heart transplant and its association with donor-recipient size matching.Methods clinical, echocardiographic and haemodynamic data from a retrospective cohort of heart transplant recipients and respective donors were reviewed.Coupling between rv-pa was examined by assessing the rv fractional area change and pulmonary artery systolic pressure ratio.Donor-recipient size matching was assessed by the predicted heart mass (phm) ratio, and groups with a phm ratio <1 and ≥1 were compared.Results forty-four heart transplant recipients were included in this study (50 years, 57% male sex).Postoperative rv-pa coupling improved from 7 to 30 days (rv fractional area change/pulmonary artery systolic pressure 0.9 ± 0.3 vs 1.2 ± 0.3; p < 0.001).A positive association was found between an adequate phm ratio and improvement of rv fractional area change/pulmonary artery systolic pressure at 30 days, independent of graft ischaemic time and pre-existent pulmonary hypertension (b coefficient 0.54; 95% confidence interval 0.11-0.97; p = 0.016; adjusted r2 = 0.24).Conclusions these findings highlight the role of phm as a metric to help donor selection and suggest its impact in rv-pa coupling interactions post-heart transplant.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021)
Publication types: Journal Article
Complications and hospital costs during hematopoietic stem cell transplantation for non-Hodgkin lymphoma in the United States.

While the initial hospitalization accounts for 75% of total healthcare costs during the first 100 days following hematopoietic stem cell transplantation (hsct), there is a lack of studies evaluating the considerable variation in cost estimates.Using the national inpatient sample (nis) database from 2012-2014, we identified 1832 adult non-hodgkin lymphoma (nhl) patients who received autologous or allogeneic hsct and examined complications as predictors of hospital cost.Complications occurred in >70% of patients, and the presence of one or more complications was associated with an increase in mean hospital costs of 46% in autologous hsct and 81% in allogeneic hsct.The most common complications (∼40%) were mucositis, febrile neutropenia, and infection.Acute organ failure, acute graft-versus-host disease, and death were less frequent (∼10%) but had a greater impact on increasing hospital costs and length of stays.Despite recent advances in supportive care and pre-conditioning regimens, complications are common and costly during hsct.

Journal: Leukemia & lymphoma (2019)
Publication types: Journal Article
Objective rapid eye movement sleep characteristics of recurrent isolated sleep paralysis: a case-control study.

Study objectives recurrent isolated sleep paralysis (risp) is a rapid eye movement (rem) parasomnia characterized by a dissociative state with characteristics of rem sleep and wakefulness.Pathophysiology has not yet been clarified and very little research has been performed using objective polysomnographic measures with inconsistent results.The main aim of our study was to find whether higher rem sleep fragmentation is consistent with the theory of state dissociation or whether signs of dissociation can be detected by spectral analysis.Methods a total of 19 participants in the risp group and 19 age- and gender-matched participants in the control group underwent two consecutive full-night video-polysomnography recordings with 19-channel electroencephalography.Apart from sleep macrostructure, other rem sleep characteristics such as rem sleep arousal index, percentage of wakefulness and stage shifts within rem sleep period were analyzed, as well as power spectral analysis during rem sleep.Results no difference was found in the macrostructural parameters of rem sleep (percentage of rem sleep and rem latency).Similarly, no significant difference was detected in rem sleep fragmentation (assessed by rem sleep arousal index, percentage of wakefulness and stage shifts within rem sleep).Power spectral analysis showed higher bifrontal beta activity in the risp group during rem sleep.Conclusions the results showed an underlying persistent trait of higher cortical activity that may predispose patients with sleep paralysis to be more likely to experience recurrent episodes, without any apparent macrostructural features including higher rem sleep fragmentation.

Journal: Sleep (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Optical emissivity dataset of multi-material heterogeneous designs generated with automated figure extraction.

Optical device design is typically an iterative optimization process based on a good initial guess from prior reports.Optical properties databases are useful in this process but difficult to compile because their parsing requires finding relevant papers and manually converting graphical emissivity curves to data tables.Here, we present two contributions: one is a dataset of thermal emissivity records with design-related parameters, and the other is a software tool for automated colored curve data extraction from scientific plots.We manually collected 64 papers with 176 figures reporting thermal emissivity and automatically retrieved 153 colored curve data records.The automated figure analysis software pipeline uses faster r-cnn for axes and legend object detection, easy ocr for axes numbering recognition, and k-means clustering for colored curve retrieval.Additionally, we manually extracted geometry, materials, and method information from the text to add necessary metadata to each emissivity curve.Finally, we analyzed the dataset to determine the dominant classes of emissivity curves and determine the underlying design parameters leading to a type of emissivity profile.

Journal: Scientific data (2022)
Publication types: Journal Article
Facile Synthesis of ZnS/1T-2H MoS2nanocomposite for Boosted adsorption/photocatalytic degradation of methylene blue under visiblelight.

Facile solvothermal techniques were used to manufacture zn s/1t-2h mo s2nanocomposite (zms) with outstanding adsorption-photocatalytic activity.The formed catalyst was characterized by different tools; xrd, hr-tem, edx, ftir, raman, n2adsorprion/desorption, zeta potential, pl,and xps.The analysis provided the formation on mixed phase of metallic 1tand 2h phases.Zms has a high porosity and large specific surface area, and it has a high synergistic adsorption-photocatalytic degradation effect for mb, with a removal efficiency of ≈100% in 45 minutes under visible light irradiation.The extraordinary mb removal efficiency of zms was attributed not only to the high specific surface area (49.15 m2/g) and precious reactive sites generated by zms, but also to the formation of 1t and 2h phases if compared to pristine mo s2(ms).The best adsorption affinity was induced by the existance of 1t phase.The remarkably enhanced photocatalytic activity of zms nanocomposite can be ascribed to the 2d heterostructure which enhances the adsorption for pollutants, provides abundant reaction active sites, extends the photoresponse to visible light region.

Journal: Environmental science and pollution research international (2022)
Publication types: Journal Article
Inter-professional relationships in the Family Health Strategy: perception of health management.

S to analyze the teamwork in the family health strategy from the perspective of professionals from the primary care department and the municipal manager/secretary of health of a municipal health secretariat.Methods an exploratory/qualitative study.All professionals of the department and municipal manager/municipal health secretary/interior of minas gerais participated.Data collection was through semi-structured interviews/may to november/2019.Data analysis: content analysis/thematic mode and work process theoretical referential.Results three categories emerged: inter-professional relations permeated by non-material instruments of work; professional training, experience, and profile influence teamwork; and proposals for the realization of teamwork in the family health strategy.Results revealed assumptions for teamwork in the referred strategy, facilitators/difficulties/strategies for its realization, according to the professionals.Final considerations: collaboration/communication/proactivity to facilitate teamwork.Need for approximation between municipal management and family health strategy to achieve teamwork.

Journal: Revista brasileira de enfermagem (2022)
Publication types: Journal Article
Prognostic Value of Transaminases and Bilirubin Levels at Admission to Hospital on Disease Progression and Mortality in Patients with COVID-19-An Observational Retrospective Study.

Introduction given the impact of covid-19 on the world healthcare system, and the efforts of the healthcare community to find prognostic factors for hospitalization, disease progression, and mortality, the aim of the present study was to investigate the prognostic impact of transaminases and bilirubin levels at admission to hospital on disease progression and mortality in covid-19 patients.Methods using the covi camp database, we performed a multicenter, observational, retrospective study involving 17 covid-19 units in southern italy.We included all adult patients hospitalized for sars-co v-2 infection with at least one determination at hospital admission of aminotransaminases and/or total bilirubin.Results of the 2054 patients included in the covi camp database, 1641 were included in our study; 789 patients (48%) were considered to have mild covid-19, 347 (21%) moderate covid-19, 354 (22%) severe covid-19, and 151 patients (9%) died during hospitalization.Older age (odds ratio (or): 1.02; 95% confidence interval (ci) 1.01-1.03), higher charlson comorbidity index (cci) (or 1.088; 95%ci 1.005-1.18), presence of dementia (or: 2.20; 95% ci: 1.30-3.73), higher serum ast (or: 1.002; 95% ci: 1.0001-1.004), and total bilirubin (or: 1.09; 95% ci: 1.002-1.19) values were associated with a more severe clinical outcome.Instead, the 151 patients who died during hospitalization showed a higher serum bilirubin value at admission (or 1.1165; 95% ci: 1.017-1.335); the same did not apply for ast.Discussion patients with covid-19 with higher levels of ast and bilirubin had an increased risk of disease progression.

Journal: Pathogens (Basel, Switzerland) (2022)
Publication types: Journal Article
Time to Recovery from Covid-19 and Its Predictors Among Patients Admitted to Treatment Centers of Southern Nations Nationalities and Peoples Region (SNNPR), ETHIOPIA: Multi-Center Retrospective Cohort Study.

The world is currently facing a pandemic of coronavirus disease 2019 (covid-19).It has caused significant morbidity and mortality.So far little is known about recovery time (prolonged hospital stay) from covid-19 and its determinants in ethiopia as well as in the study area.Therefore, the aim of this study was to determine time to recovery from covid-19, and identify predictors of time to recovery among patients admitted to treatment centers of southern nations nationalities and peoples region (snnpr).Methods and materials a facility-based retrospective cohort study was conducted among covid-19 patients admitted to care centers of snnpr from may 30, 2020 to october 15, 2021.A sample of 845 patients was included in the study.Summarization of the data was done using mean (standard deviation) and median (inter quartile range).Kaplan-meier survival curve was used to estimate recovery time from covid-19 and the independent effects of covariates on recovery time was analyzed using multivariable cox-proportional hazard model.Results the incidence density of recovery was 8.24 per 100 person-days (95% ci: 7.67, 8.85).The overall median recovery time was 10 days (iqr: 8-16 days).Critical stage of covid-19 (a hr = 0.19, 95% ci: 0.12, 0.29), severe stage of covid-19 (a hr = 0.40, 95% ci: 0.29, 0.56), mechanical ventilation (a hr = 0.20, 95% ci: 0.073, 0.56) and treatment center (a hr = 0.68, 95% ci: 0.51, 0.90) were significant predictors of recovery rate among covid-19 patients.Conclusion the median time to recovery from covid-19 was relatively short.The incidence density of recovery was 8.24 per 100 person-days.The hazard of recovery was lower for patients at higher levels of covid-19 severity and for patients in need of mechanical ventilation.Early identification of severity levels of the patients is required at the time of admission.Special attention, critical follow-up and management is warranted for patients at higher levels of covid-19 severity.

Journal: Infection and drug resistance (2022)
Publication types: Journal Article
Domain generalization on medical imaging classification using episodic training with task augmentation.

Medical imaging datasets usually exhibit domain shift due to the variations of scanner vendors, imaging protocols, etc.This raises the concern about the generalization capacity of machine learning models.Domain generalization (dg), which aims to learn a model from multiple source domains such that it can be directly generalized to unseen test domains, seems particularly promising to medical imaging community.To address dg, recent model-agnostic meta-learning (maml) has been introduced, which transfers the knowledge from previous training tasks to facilitate the learning of novel testing tasks.However, in clinical practice, there are usually only a few annotated source domains available, which decreases the capacity of training task generation and thus increases the risk of overfitting to training tasks in the paradigm.In this paper, we propose a novel dg scheme of episodic training with task augmentation on medical imaging classification.Based on meta-learning, we develop the paradigm of episodic training to construct the knowledge transfer from episodic training-task simulation to the real testing task of dg.Motivated by the limited number of source domains in real-world medical deployment, we consider the unique task-level overfitting and we propose task augmentation to enhance the variety during training task generation to alleviate it.With the established learning framework, we further exploit a novel meta-objective to regularize the deep embedding of training domains.To validate the effectiveness of the proposed method, we perform experiments on histopathological images and abdominal ct images.

Journal: Computers in biology and medicine (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Down-regulation of toll-like receptor 4 alleviates intestinal ischemia reperfusion injury and acute lung injury in mice.

Intestinal ischemia reperfusion (ir) injury is a critical problem, which can cause intestinal injury locally and acute lung injury (ali) distally by inflammatory responses and oxidative stress.Toll-like receptor 4 (tlr4) is involved in innate immune and inflammatory responses.This study was to determine whether tlr4 mutant can attenuate intestinal and lung injuries after intestinal ir.Wild type (wt) and tlr4 mutant mice were submitted to intestinal ir by occluding the superior mesenteric artery.Histological assessment of the intestine and the lung were conducted by he staining.The levels of proinflammatory cytokines, oxidative stress markers, apoptotic index and other mediators were measured.In addition, a 24-hour survival study was performed.Histological assessment showed that intestinal ir caused serious injuries in the intestine and the lung, corroborated by increased proinflammatory cytokines in the circulation.Tlr4 mutant suppressed the histological injuries as demonstrated by significantly decreased pathological scores.Consistent with the morphological results, the tlr4 mutant mice exhibited remarkably lowered cytokine expressions in the intestine (tnf-α, il-6, il-1β, and nf-κb) and the lung (no, i nos, mcp-1, mip-2, nf-κb, and caspase-3).Alt and creatinine were also significantly dampened in the liver and kidney, respectively.Furthermore, the survival rate over the course of 24 hours was significantly improved.Collectively, the findings reveal that tlr4 mutant significantly abated the intestinal ir injury and ali at least in part by alleviating the inflammatory response and oxidative stress.

Journal: Oncotarget (2017)
Publication types: Journal Article
B cell activation in the cecal patches during the development of an experimental colitis model.

Although previous studies have suggested that appendix seems to be involved in the colitis, the role of this in the pathogenesis remains unclear.In this study, we assessed the importance of appendiceal lymphoid follicles, specifically the cecal patches (cp) in mice, using an experimental colitis model.Treatment with oxazolone resulted in ulcerations particularly at cp with follicular expansion as well as colitis.The colitis was attenuated by either appendectomy or the absence of mature b cells.We therefore established an intravital imaging system accompanied by the fluorescence resonance energy transfer technology to analyze the dynamic immune response of cp b cells.Our observation revealed frequent ca2+signaling in cp b cells during the early phase of colitis development.These findings suggested that the cp b cells may be involved in the pathogenesis of colitis including inflammatory bowel diseases in humans.

Journal: Biochemical and biophysical research communications (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Anti-CD81 antibody blocks vertical transmission of avian leukosis virus subgroup J.

Control of alv-j in breed of chicken is still a serious issue that need more attention to be paid.Vertical transmission of alv-j often give rise to more adverse pathogenicity.However, the way to elimination of alv-j underlying vertical transmission remains not-well understood.In addition, effective vaccines or drugs have not been developed to prevent and control the transmission of alv-j so far.Cd81, a member of the tetraspanins superfamily, plays important roles in regulating membrane proteins, facilitating cells adhesion or fusion, and also participates in viral infection.The purpose of this study was to investigate whether antibodies against certain tetraspanins affect infection of alv-j.Here, we showed that anti-cd81 antibody could inhibit viral rna and protein level.We also found that anti-cd81 antibody interacts with viral protein p27, p32 and gp37.Moreover, treatment with antibody to cd81 can effectively prevent the vertical transmission of alv-j in animal model.Collectively, current study provides new avenues for the control of alv-j transmission.

Journal: Veterinary microbiology (2022)
Publication types: Journal Article
A novel viewpoint to the green city concept based on vegetation area changes and contributions to healthy days: a case study of Mashhad, Iran.

One of the significant challenges in urbanization is the air pollution.This highlights the need of the green city concept with reconsideration of houses, factories, and traffic in a green viewpoint.The literature review confirms that this reconsideration for green space has a positive effect on the air quality of large cities and to reduce the air pollution.The purpose of this study is to evaluate the annual vegetation changes in the green space of mashhad, iran as a very populated city in the middle east to study the air pollution.To investigate the relationship between the air pollution and vegetation, the landsat 8 satellite images for summer seasons of 2013-2019 were used to extract changes in vegetation by calculating the normalized difference vegetation index (ndvi), enhanced vegetation index (evi), and the optimized soil adjusted vegetation index (osavi).The main contribution in comparison with the relevant studies is to study the relationship between clean, healthy, and unhealthy days with the green space area for the first time in mashhad, iran.The results show that the implementation of green city concept in mashhad, iran, has been increased by 64, 81, and 53% by ndvi, evi, and osavi, respectively, during the study period.The vegetation area of this city is positively correlated to clean and healthy days and has a negative correlation to unhealthy days, in which the greatest values for ndvi, evi and osavi are 0.33, 0.52, and -0.53, respectively.

Journal: Environmental science and pollution research international (2022)
Publication types: Journal Article
Prognostic value of lymph node micrometastasis in esophageal cancer: A systematic review and meta-analysis.

Whether lymph node micrometastasis (lnm) increases the risk in esophageal cancer patients remains controversial.We conducted a systematic review and meta-analysis to explore the prognosis value of lnm in esophageal cancer patients.Methods two reviewers independently searched electronic databases, including pub med, embase, and the cochrane library, for eligible citations until february 2022.We calculated pooled estimates of the hazards ratio with a random-effects model.The certainty of evidence was determined by the grade of recommendations assessment, development, and evaluation (grade) method.A sensitivity analysis was performed to assess the stability.Publication bias was assessed using funnel plots and egger's test.We also performed subgroup analysis to explore the source of heterogeneity.Results a total of 16 studies, with 1,652 patients, were included.The overall survival (os) was significantly increased with lnm negativity compared with lnm positivity (hr 1.95; 95% ci, 1.53-2.49;p <0.001;i2= 0.0%,p= 0.930; certainty of evidence: low).Relapse-free survival (rfs) was significantly increased with lnm negativity compared with lnm positivity (hr 3.39; 95% ci, 1.87-6.16;p <0.001;i2= 50.18%,p= 0.060; certainty of evidence: moderate).No significant difference was observed in recurrence between the two groups (certainty of evidence: low).Sensitivity analysis revealed a stable trend.In addition, the funnel plot and egger's test did not show significant publication bias.Conclusion lnm positivity worsens the prognosis in esophageal cancer, and the evidence for rfs is moderate.Future relevant high-quality studies are warranted to validate our results further and provide a reference for guidelines.Systematic review registration identifier (crd42022321768).

Journal: Frontiers in oncology (2022)
Publication types: Systematic Review;Journal Article
Tick-borne encephalitis in pregnant women: A mini narrative review.

Tick-borne encephalitis (tbe) incidence has been increasing in europe the last decades, but very few cases in pregnant women have been described.We present two cases and describe the serology of both mother and infant at the time of diagnosis and delivery, as well as at months 3, 6, 9, and 12 of follow-up.In both cases, pregnancies and infants developed normally.The mothers had moderate-to severe symptoms of tbe and were positive for ig m and ig g at the time of diagnosis, and throughout the follow up period whilst both infants were pcr- and ig m-negative and positive for ig g during their first months in life.Declining ig g titres were seen in the infants during follow-up until they became negative at the age of nine months.Tbe ig g was vertically transmitted in these two cases of infants born to tbe-infected mothers.

Journal: New microbes and new infections (2022)
Publication types: Journal Article;Review