syedzayyan/paper_mill_benchmark huggingface dataset:
Substance use, psychiatric symptoms, personal mastery, and social support among COVID-19 long haulers: A compensatory model.

Substance use has become a critical health concern during the covid-19 pandemic, and emerging attention has been paid to people with the persistent symptoms of covid-19 (covid-19 long haulers) due to their high vulnerability.However, scant research has investigated their substance use and relevant psychosocial factors.The current study was to (1) examine substance use behaviors (i.e., legal drug use, illicit drug use, and non-medical use of prescription drugs); and (2) assessed their associations with psychiatric symptoms (i.e., depression, anxiety, and post-traumatic stress disorder) and psychosocial factors (i.e., personal mastery and social support) among covid-19 long haulers.Methods in january - march 2022, 460 covid-19 long haulers (50% female), with an average age of 32, completed online surveys regarding their demographics, substance use, psychiatric symptoms, and psychosocial factors.Results in the past three months, the most commonly used or non-medically used substances were tobacco (82%) for legal drugs, cocaine (53%) for illicit drugs, and prescription opioids (67%) for prescription drugs.Structural equation modeling suggested that psychiatric symptoms were positively associated with substance use behaviors (βs = .38 to .68,ps < .001), while psychosocial factors were negatively associated with substance use behaviors (βs = -.61 to -.43,ps < .001).Conclusion substance use is common in covid-19 long haulers and psychiatric symptoms are the risk factors.Personal mastery and social support appear to offer protection offsetting the psychiatric influences.Substance use prevention and mental health services for covid-19 long haulers should attend to personal mastery and social support.

Journal: medRxiv : the preprint server for health sciences (2022)
Publication types: Preprint;Journal Article
Could Endogenous Glucocorticoids Influence SARS-CoV-2 Infectivity?

Endogenous glucocorticoids and their synthetic analogues, such as dexamethasone, stimulate receptor-mediated signal transduction mechanisms on target cells.Some of these mechanisms result in beneficial outcomes whereas others are deleterious in the settings of pathogen infections and immunological disorders.Here, we review recent studies by several groups, including our group, showing that glucocorticoids can directly interact with protein components on sars-co v-2, the causative agent of covid-19.We postulate an antiviral defence mechanism by which endogenous glucocorticoids (e.g., cortisol produced in response to sars-co v-2 infection) can bind to multiple sites on sars-co v-2 surface protein, spike, inducing conformational alterations in spike subunit 1 (s1) that inhibit sars-co v-2 interaction with the host sars-co v-2 receptor, ace2.We suggest that glucocorticoids-mediated inhibition of s1 interaction with ace2 may, consequently, affect sars-co v-2 infectivity.Further, glucocorticoids interactions with spike could protect against a broad spectrum of coronaviruses and their variants that utilize spike for infection of the host.These notions may be useful for the design of new antivirals for coronavirus diseases.

Journal: Cells (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't
Idiopathic Ventricular Arrhythmias Originating from Different Portions of the Coronary Venous System: Prevalence, Electrocardiographic Characteristics, Catheter Ablation, and Complications.

(1) background: to determine the prevalence, electrocardiographic characteristics, mapping, and ablation of ivas arising from the cvs.(2) methods: detailed activation and pace mapping of the cvs ivas was performed before attempted radiofrequency ablation (rfca).(3) results: the ivas originating from the vicinity of the cvs represented approximately 5.27% (164/3113) of all ivas; 94.51% (155/164) cases were accessed at the earliest identified site and 83.54% (137/164) ivas were successfully ablated.The main coronary vein group had a relatively short procedure time, short fluoroscopy time, fewer radiofrequency lesions prior to success, and less swartz sheath support.Ivas originating from the cvs had distinct ecg characteristics: rs, rs or r s (with s or s) wave in lead v1 indicate the vas arising from the proximal portion of the anterior interventricular vein (aiv) and summit-cv; rs (with s or s) wave in leads v5−v6 indicate the vas arising from the adjacent regions of the distal great cardiac vein 1 (dgcv1); positive wave (r, rs or r) in lead i indicate the vas ori”inat’ng from summit-cv and posterior wall subgroup (including middle cardiac vein [mcv], posterior lateral vein [plv], coronary sinus [cs]).Compared with the ivas originating from the endocardial mitral annulus, a pd w > 45 ms, an idt > 74 ms, and an mdi > 0.50 indicate a cvs origin of the ivas.The common peri-procedure complications were cv dissection (6.45%, 10/155), cv rupture (1.29%, 2/155), coronary artery spasm (1.29%, 2/155), coronary artery stenosis (0.65%, 1/155), pericardial effusion (0.65%, 1/155) and tamponade (1.29%, 2/155).Stenosis of coronary arteries was not observed at the adjacent ablation site in the cvs during follow-up.(4) conclusions: v as arising from the cvs are not a rare phenomenon.Several ecg and procedure characteristics could help regionalize, map, and ablate the origin of ivas from different portions of the cvs.Rfca within the cvs was relatively effective and safe.

Journal: Journal of cardiovascular development and disease (2022)
Publication types: Journal Article
In-Depth Investigation of Conjunctival Swabs and Tear Fluid of Symptomatic COVID-19 Patients, an Observational Cohort Study.

The putative presence of sars-co v-2 in ocular specimen puts healthcare workers at risk.We thoroughly examined conjunctival swabs and tear fluid in a large cohort of covid-19 patients.Methods a total of 243 symptomatic laboratory-confirmed covid-19 patients were included in this observational multicenter study.Conjunctival swabs were analyzed by reverse transcription polymerase chain reaction for detection of sars-co v-2 rna.Next-generation sequencing and phylogenetic analysis were performed to identify viral strains and to determine tissue tropism.Schirmer tear samples from 43 hospitalized covid-19 patients and 25 healthy controls were analyzed by multiplex cytokine immunoassays.Results viral sars-co v-2 rna was detected in conjunctival swabs from 17 (7.0%) of 243 covid-19 patients.Conjunctival samples were positive for viral sars-co v-2 rna as long as 12 days after disease onset.Cycle threshold (ct) values for conjunctival swabs (mean 34.5 ± 5.1) were significantly higher than nasopharyngeal swabs (mean 16.7 ± 3.6).No correlation between ct values of conjunctival and nasopharyngeal swabs was observed.The majority of positive conjunctival samples were detected only once and primarily during the first visit.Next-generation sequencing analysis revealed that the virus strain found in the conjunctiva was most often identical to the one found in the nasopharynx.Tear cytokine levels il-1β and il-6 were elevated in covid-19 patients compared to healthy controls.Conclusions conjunctival samples that were positive for sars-co v-2 rna contained the same viral strain as the nasopharynx.Translational relevance the presence of sars-co v-2 viral rna and elevated cytokines in tear fluid confirm the involvement of the ocular surface in covid-19 disease.

Journal: Translational vision science & technology (2021)
Publication types: Journal Article;Multicenter Study;Observational Study
Risk of Major Mental Disorder after Severe Bacterial Infections in Children and Adolescents: A Nationwide Longitudinal Study.

Introduction evidence has suggested an association between bacterial infection and increased risk of subsequent major mental disorders (mmds).Whether such association varies with different pathogens remains unclear.We aimed to investigate the risk of subsequent mmds after exposure to bacterial pathogens in children and adolescents.Methods between 1997 and 2012, we enrolled a nationwide cohort of 14,024 children and adolescents with hospitalized bacterial infection, and noninfected controls were 1:4 matched for demographics.There were 11 investigated pathogens, namely, streptococcus, staphylococcus, pseudomonas, klebsiella, hemophilus, mycoplasma, tuberculosis, meningococcus, escherichia, chlamydia, and scrub typhus.The primary outcomes were the subsequent risk of seven mmds, namely, autism spectrum disorder (asd), attention-deficiency hyperactivity disorder (adhd), obsessive-compulsive disorder (ocd), tic disorder, schizophrenia, bipolar disorder, and depressive disorder.The secondary outcomes were the subsequent risk of exposure to psychotropic medications.Results pooled bacterial infection was associated with increased risk of the six mmds - asd (reported as hazard ratios with 95% confidence intervals: 13.80; 7.40-25.75), adhd (6.93; 5.98-8.03), ocd (3.93; 1.76-8.76), tic disorder (6.19; 4.44-8.64), bipolar disorder (2.50; 1.28-4.86), and depressive disorder (1.93; 1.48-2.51) - and exposure to four psychotropic medications, including adhd drugs (11.81; 9.72-14.35), antidepressants (2.96; 2.45-3.57), mood stabilizers (4.51; 2.83-7.19), and atypical antipsychotics (4.23; 3.00-5.96) compared to controls.The associations among mmds and specific pathogens varied.Importantly, streptococcus was associated with the most mmds (six mmds), and adhd was associated with eight bacterial pathogen infections.Conclusions after bacterial infection, the risk of mmds increased in children and adolescents compared to controls, and such associations varied with different pathogens.Future studies are warranted to validate our study findings and investigate the potential mechanisms.

Journal: Neuropsychobiology (2022)
Publication types: Journal Article
Distribution of Kudoa thyrsites (Cnidaria, Myxozoa) myoliquefactive stages in Northeast Atlantic mackerel (Scomber scombrus) inferred from qPCR and histology.

Kudoa thyrsites is a myxosporean parasite (cnidaria, myxozoa) that infects the skeletal and cardiac muscle of northeast atlantic (nea) mackerel (scomber scombrus).Heavy infections are associated with post-mortem myoliquefaction of the host skeletal muscle which reduces the quality of the fish product.The biological infection characteristics of the parasite in nea mackerel are poorly known.This study examined the distribution of k.Thyrsites in various organs of nea mackerel from the northern north sea, and elucidates the relationship between density of infection, developmental stage and parasite distribution in the musculature, and the extent of visible flesh myoliquefaction.Quantitative polymerase chain reaction (q pcr) data showed that k.Thyrsites is unevenly distributed in the somatic musculature of the fish host, with highest density in the anterior ventral muscle sections-the belly flaps.A weak positive correlation was observed between the level of myoliquefaction and the parasite density in the fish host muscle.This relationship was also reflected by the amount and distribution of parasite developmental stages seen during histological examinations.Histological findings indicate an association between the dispersion of free myxospores and the level of myoliquefaction of the fish host muscle.Visceral organs were also found infected using q pcr, although at lower densities compared to the musculature.

Journal: Parasitology research (2022)
Publication types: Journal Article
Towards-Person Vocalization Effect on Screening for Autism Spectrum Disorders in the Context of Frustration.

The purpose of this study is to investigate the vocalization characteristics of infants with autism spectrum disorder (asd) in the context of frustration.The duration and frequency of vocalization in 48 infants with asd and 65 infants with typical development (td) were followed up to 24 months later for subsequent diagnosis.The typical vocalizations of infants with asd were retrospectively analyzed, such as speech-like vocalizations, nonspeech vocalizations, vocalizations towards the person and non-social vocalizations.The results showed that, compared with the td group, vocalizations of infants with asd during the still-face period had lower typical vocalizations and characteristics associated with social intention, and that these characteristics were closely related to the clinical symptoms of asd, among which vocalizations towards the person accompanied by social intention had discriminative efficacy.

Journal: Brain sciences (2021)
Publication types: Journal Article
Chromium doping: A new approach to regulate electronic structure of cobalt carbonate hydroxide for oxygen evolution improvement.

Highly efficient catalysts are required to solve the intrinsically sluggish kinetics of oxygen evolution reaction (oer).Herein, chromium doped cobalt carbonate hydroxide nanowire array on ni foam (cr-co ch/nf) has been synthesized for the enhancement of oer activity and stability.Compared with pure co ch/nf, cr0.2-co ch/nf, the optimal doping of cr, shows a low overpotential of 203 m v at the current density of 10 m a cm-2and a small tafel slope of 84 m v dec-1in 1.0 m na oh.In addition, there is little deterioration in electrocatalytic performance after 1000-cycle cyclic voltammetry and the high activity can be maintained over 25 h.Density functional theory calculations reveal the cr doping can regulate the electronic structure of nearby co active center to achieve great enhancement of oer activity.

Journal: Journal of colloid and interface science (2022)
Publication types: Journal Article
Cross-cultural adaptation, validation, and the reliability of the Sleep-Related Behaviors Questionnaire in patients with multiple sclerosis.

Examining sleep-related behavioral disorder strategies in detail for ms patients provides an essential assessment to address specific disease findings.The aim of the study was to demonstrate the reliability and validity of the turkish sleep-related behaviors questionnaire in patients with multiple sclerosis (ms).Methods a total of 100 ms patients were filled sleep-related behaviors questionnaire (srbq), beck depression inventory (bdi), insomnia severity index (isi), and pittsburgh sleep quality index (psqi).One week later, 30 randomly selected patients were refilled the srbq.The test-retest reliability, internal consistency, and contruct validity were determined.Results the mean age of the individuals included in the study was 38.9 ± 11.0 years.The icc value of the reproducibility of srbq was calculated as 0.877 (ci: 0.74-0.94).The test-retest reliability of the srbq was excellent (icc > 0.80).Cronbach's alpha value of the srbq was 0.877, which indicates excellent consistency.The srbq had correlation coefficients of 0.573, 0.509, and 0.523 with isi, psqi, and bdi, respectively.The srbq had high validity (r > 0.50, p < 0.01).Conclusion the turkish srbq was found to be valid and reliable in patients with ms.Owing to the long but comprehensive nature of the srbq, a low-cost detailed measurement could be obtained in clinical practice.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2022)
Publication types: Journal Article
DualG-GAN, a Dual-channel Generator based Generative Adversarial Network for text-to-face synthesis.

Text-to-image synthesis is a fundamental and challenging task in computer vision, which aims to synthesize realistic images from given descriptions.Recently, text-to-image synthesis methods have achieved great improvements in the quality of synthesized images.However, very few works have explored its application in the scenario of face synthesis, which is of great potentials in face-related applications and the public safety domain.On the other side, the faces generated by existing methods are generally of poor quality and have low consistency to the given text.To tackle this issue, in this paper, we build a novel end-to-end dual-channel generator based generative adversarial network, named dual g-gan, to improve the quality of the generated images and the consistency to the text description.In dual g-gan, to improve the consistency between the synthesized image and the input description, a dual-channel generator block is introduced, and a novel loss is designed to improve the similarity between the generated image and the ground-truth in three different semantic levels.Extensive experiments demonstrate that dual g-gan achieves state-of-the-art results on scu-text2face dataset.To further verify the performance of dual g-gan, we compare it with the current optimal methods on text-to-image synthesis tasks, where quantitative and qualitative results show that the proposed dual g-gan achieves optimal performance in both fréchet inception distance (fid) and r-precision metrics.As only a few works are focusing on text-to-face synthesis, this work can be seen as a baseline for future research.

Journal: Neural networks : the official journal of the International Neural Network Society (2022)
Publication types: Journal Article
Benchtop nuclear magnetic resonance-based metabolomic approach for the diagnosis of bovine tuberculosis.

Even though enormous efforts and control strategies have been implemented, bovine tuberculosis (tb) remains a significant source of health and socioeconomic concern.The standard method used in tb eradication programs for in vivo detection is the tuberculin skin test.However, the specificity of the tuberculin skin test is affected by infection with non-tuberculous mycobacteria or by vaccination.Thus, some animals are not correctly diagnosed.This study aimed first to identify a plasma metabolic tb profile by high-field (hf) nuclear magnetic resonance (nmr) spectroscopy and second measure this characteristic tb metabolic profile using low-field benchtop (lf) nmr as an affordable molecular technology for tb diagnosis.Plasma samples from cattle diagnosed with tb (derivation set, n = 11), diagnosed with paratuberculosis (ptb, n = 10), ptb-vaccinated healthy control (n = 10) and healthy ptb-unvaccinated control (n = 10) were analyzed by nmr.Unsupervised principal component analysis (pca) was used to identify metabolic differences between groups.We identified 14 metabolites significantly different between tb and control animals.The second group of tb animals was used to validate the results (validation set, n = 14).Predictive models based on metabolic fingerprint acquired by both hf and lf nmr spectroscopy successfully identified tb versus control subjects (area under the curve of receiver operating characteristic over 0.92, in both models; confidence interval 0.77-1).In summary, plasma fingerprinting using hf and lf-nmr differentiated tb subjects from uninfected animals, and ptb and ptb-vaccinated subjects who may provide a tb-false positive, highlighting the use of lf-nmr-based metabolomics as a complementary or alternative diagnostic tool to the current diagnostic methods.

Journal: Transboundary and emerging diseases (2022)
Publication types: Journal Article
Association between changes in hip-knee-ankle angle and hindfoot alignment after total knee arthroplasty for varus knee osteoarthritis.

The change in hip-knee-ankle (hka) angle after total knee arthroplasty (tka) may cause an adjustment in hindfoot alignment (hfa).However, the relationship between the changes in hka angle and hfa is still not well studied.This study aimed to investigate the association between hka angle and hindfoot alignment changes after tka for varus knee osteoarthritis.Methods a prospective study was carried out in which 108 patients with varus knee deformities were radiographically and clinically evaluated before and 3 months after tka.The relationship of change in hfa with correction in hka angle was investigated.Results the results showed that the hfa was adjusted significantly by 3 months after tka (p < 0.001), along with improved american orthopaedic foot and ankle society (aofas) ankle hindfoot score (p < 0.001).Next, a univariate correlation and linear regression analysis showed that the change in hfa was weakly correlated with the change in hka angle (r=-0.262, β=-0.14, 95 % ci: -0.23 to -0.04, p = 0.006).Further stratified analysis and interaction tests revealed that age has a distinct effect on the correlation between the changes in hfa and hka angle.The correlation was dramatically greater in the group under 65 years (r=-0.474, β=-0.26, 95 % ci: -0.41 to -0.12, p = 0.001), whilst, no correlation was observed in those above 65 years old (r=-0.036, β=-0.02, 95 % ci: -0.14 to 0.11, p = 0.779).Conclusions our findings indicated that correction of hka after tka tend to promote adjustment in the hindfoot alignment toward re-balance of the whole lower limb weight-bearing axis.However, this mechanism obviously weakens in elderly patients.Therefore, if apparent hindfoot deformity exists in these patients before tka, more perioperative intervention is required for hindfoot adjustment, and even hka undercorrection may be considered.

Journal: BMC musculoskeletal disorders (2021)
Publication types: Journal Article
Evaluation of the relevance of use of the BD-BACTEC®MycosisIC/F, BD-BACTEC®PlusAerobic/F, BD-BACTEC®Lytic/10 anaerobic/F and BD-BACTEC®PedsPlus/F culture bottle system for fungemia detection: A 4-year retrospective study at the Dijon university hospital, France.

Introduction fungemia is a severe invasive fungal infection that combines rapid progression and a high mortality rate.This type of infection is a vital emergency, and early diagnosis is crucial.Currently, only the bd-bactec® automated blood culture system (becton dickinson, new jersey, usa) has a medium specifically dedicated to the detection of fungal agents: the bd-bactec®mycosis ic/f bottle.Gap statement thus, it is important to assess the performance of the different bottles offered by the bd-bactec® automated blood culture system for the diagnosis of fungemia.Aim the aim of this study was to evaluate the performance of the bd-bactec® mycosis ic/f culture medium in comparison to bacteriologic culture bottle media for the detection of fungemia in different clinical situations.Methodology this retrospective study was conducted over a period of 4 years at the dijon university hospital.Three hundred and thirty-one pairs of blood cultures (i.e.A bd-bactec® mycosis ic/f culture bottle associated with at least one bacteriologic culture media bottle) were included in this study.Results we showed that the bd-bactec® mycosis ic/f culture bottles performed significantly better (i.e.Diagnostic advantage either because it was the only positive bottle of the pair or time to positive result was shorter) than the bacteriological culture bottles in 57.7% (191/331) of cases (p <0.01).Multivariate analysis revealed that bd-bactec®mycosis ic/f bottles had better diagnostic performance than bd-bactec®bacteriologic bottles in the context of: (i) the initial versus follow-up diagnostic subgroup, (ii) venipuncture or arterial sampling versus other sampling methods, and (iii) detection of filamentous versus yeast fungi.Conclusion we concluded that the use of bd-bactec® mycosis ic/f culture bottles is a relevant addition to media optimized for routine bacterial detection.

Journal: Journal de mycologie medicale (2022)
Publication types: Journal Article