syedzayyan/paper_mill_benchmark huggingface dataset:
Effect of point-of-care influenza tests on antibiotic prescriptions by emergency physicians in a French hospital.

Influenza is a public health issue worldwide.Although antibiotics should not be used to treat viral infections, they are often prescribed to patients with influenza-like illness (ili).Such misuse promotes antibiotic resistance.The role of rapid point-of-care tests (pocts) in preventing antibiotic misuse in adults with ili symptoms remains relatively unexplored.Aim to evaluate whether poct implemented in 2018-2019 to detect influenza viruses led to a decrease in antibiotic prescriptions compared with laboratory-based influenza tests.Methods adult patients with ili in one emergency department (ed) were retrospectively enrolled over three epidemic seasons (from 2016-2017 to 2018-2019).The primary outcome was the rate of antibiotic prescriptions, which was compared between the three seasons in bivariate and multivariate analyses.Prescriptions for ancillary laboratory tests, chest x-rays and oseltamivir were also compared, along with hospitalizations and length of stay (los) at the ed.Findings overall, 1849 patients were included.Median age was over 70 years throughout all three seasons.The number of antibiotic prescriptions was significantly different between the three periods in bivariate analysis (48.3% in 2016/2017, 44% in 2017/2018 and 31.1% in 2018/2019; p<0,0001) and in multivariate analysis (adjusted odds ratio (a or) = 0.48, 95% confidence interval (ci) = 0.30-0.76 for 2018/2019 and a or = 0.99, 95%ci = 0.67-1.46 for 2017/2018, compared with 2016/2017).There were significantly fewer prescriptions of ancillary laboratory tests, x-rays, hospitalizations and more oseltamivir prescriptions in 2018/2019, compared with the previous seasons.Los was significantly lower in 2018/2019 only for influenza-positive patients.Conclusions ed influenza poct decreased antibiotic use and led to less ancillary testing, x-rays and hospitalizations among patients with ili.However, medico-economic studies are necessary before formulating definite recommendations.

Journal: The Journal of hospital infection (2022)
Publication types: Journal Article
Effect of Ratio of Residual Alveolar Bone to Graft Material in Contact With Fixture Surface on Marginal Bone Loss of Implants in Augmented Maxillary Sinuses: A 1-Year Retrospective Study.

The purpose of this retrospective study was to evaluate the influences of height or area ratio of residual alveolar bone to graft material on marginal bone loss around implants in the augmented maxillary sinuses with delayed implant placement.Materials and methods in this study, 42 patients with astra implants in sinuses that had been augmented with alloplasts and allografts or xenografts (alveolar bone height ≤ 5 mm) were selected.Marginal bone level surrounding 1 implant per sinus was assessed by radiographic imaging at the time of final restoration delivery and 12 months after functional loading.To evaluate the marginal bone level alterations using clinical and radiographic data, pearson's correlation analysis and mann-whitney test were performed.Results forty-six implants were included in this study.The residual bone/implant length ratio and the residual bone/implant area ratio were not associated with marginal bone loss at 1 year after functional loading (p > 0.05).And, marginal bone loss did not differ significantly between 2 types of graft materials during the observation period (p > 0.05).Conclusion the residual bone/implant length ratio and residual bone/implant area ratio were not associated with marginal bone loss around implants placed in augmented sinuses during 1 year of functional loading.

Journal: Implant dentistry (2017)
Publication types: Journal Article
Temporal changes in risk of cardiovascular events in people with newly diagnosed type 2 diabetes with and without cardiovascular disease.

S examine temporal changes in the risk of cardiovascular events in people with newly diagnosed type 2 diabetes with and without cardiovascular disease (cvd).Methods 283,600 individuals with newly diagnosed type 2 diabetes and age-, sex-, and cvd-matched controls without diabetes were identified through danish nationwide registries between 1997 and 2014.Using cox regression models, we report the standardized absolute 5-year risk of cardiovascular death, myocardial infarction, stroke, and heart failure for people with diabetes and controls.Results individuals with newly diagnosed diabetes were at increased risk of cardiovascular events compared to controls.From 1997-2002 to 2009-2014 reductions in cardiovascular events for people with diabetes were: cardiovascular death; 26.5% to 13.8% in people with cvd and from 7.3% to 3.2% in people without cvd, myocardial infarction; 13.1% to 6.5% in people with cvd and from 4.1% to 1.9% in people without cvd, stroke; 14.2% to 8.8% in people with cvd and from 4.9% to 2.2% in people without cvd, and heart failure; 21.0% to 13.8% in people with cvd and from 5.0% to 2.6% in people without cvd.The risk of cardiovascular events declined more among people with diabetes than controls.Conclusions newly diagnosed type 2 diabetes was associated with an increased risk of cardiovascular events, and the risk decreased significantly 1997-2014 in both people with and without cvd.Furthermore, the excess risk associated with type 2 diabetes decreased significantly during the study period.

Journal: Journal of diabetes and its complications (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Successful Percutaneous Coronary Intervention Using Intravascular Ultrasound-Guided Rewiring Technique in a Case of Spontaneous Coronary Artery Dissection Involving Left Main Bifurcation.

We herein describe a 49-year-old woman without significant cardiovascular risk factors who was transferred to our hospital with sudden onset of chest pain.The patient was diagnosed with non-st-elevation acute myocardial infarction, and coronary angiography revealed a dissection at the proximal site of the left anterior descending artery (lad) extending from the left main trunk (lmt) suggestive of spontaneous coronary artery dissection (scad).Because coronary flow was impaired after contrast injection and the patient had chest pain with st elevation, urgent percutaneous coronary intervention was performed.The first guide wire was initially introduced from the lmt to the distal lad, but intravascular ultrasound (ivus) imaging revealed that the guide wire had passed through the true lumen of the left coronary artery ostium, false lumen at the ostium of the left circumflex artery, and true lumen of the distal lad.We then reinserted another guide wire using an ivus-guided rewiring technique from the true lumen of the lmt to the distal lad.Finally, a drug-eluting stent was deployed to cover the dissected segment, and final coronary angiography revealed acceptable results with a patent left circumflex artery.This case report highlights that physicians should consider scad among the differential diagnoses in patients presenting with acute coronary syndrome, particularly in young women.In the present case, ivus played a pivotal role in not only detecting the arterial dissection but also correctly introducing the guide wire into the true lumen.

Journal: Case reports in cardiology (2020)
Publication types: Case Reports;Journal Article
Low-cost smartphone-based LIBS combined with deep learning image processing for accurate lithology recognition.

A low-cost and multi-channel smartphone-based spectrometer was developed for libs.As the cmos detector is two-dimensional, simultaneous multichannel detection was achieved by coupling a linear array of fibres for light collection.Thus, besides the atomic information, the spectral images containing the propagation and spatial distribution characters of a laser induced plasma plume could be recorded.With these additional features, accurate rock type prediction was achieved by processing the raw data directly through a deep learning model.

Journal: Chemical communications (Cambridge, England) (2021)
Publication types: Journal Article
The Mucoadhesive Nanoparticle-Based Delivery System in the Development of Mucosal Vaccines.

Mucosal tissue constitutes the largest interface between the body and the external environment, regulating the entry of pathogens, particles, and molecules.Mucosal immunization is the most effective way to trigger a protective mucosal immune response.However, the majority of the currently licensed vaccines are recommended to be administered by intramuscular injection, which has obvious shortcomings, such as high production costs, low patient compliance, and lack of mucosal immune response.Strategies for eliciting mucosal and systemic immune responses are being developed, including appropriate vaccine adjuvant, delivery system, and bacterial or viral vectors.Biodegradable mucoadhesive nanoparticles (nps) are the most promising candidate for vaccine delivery systems due to their inherent immune adjuvant property and the ability to protect the antigen from degradation, sustain the release of loaded antigen, and increase the residence time of antigen at the administration site.The current review outlined the complex structure of mucosa, the mechanism of interaction between nps and mucosa, factors affecting the mucoadhesion of nps, and the application of the delivery system based on mucoadhesive nps in the field of vaccines.Moreover, this review demonstrated that the biodegradable and mucoadhesive np-based delivery system has the potential for mucosal administration of vaccines.

Journal: International journal of nanomedicine (2022)
Publication types: Journal Article;Review
Biomimetic Microstructured Antifatigue Fracture Hydrogel Sensor for Human Motion Detection with Enhanced Sensing Sensitivity.

Antifatigue fracture performance and high sensing sensitivity are key characteristics for hydrogel sensors used in flexible electronic applications.Herein, inspired by human muscle tissues and epidermal skin tissues, an effective and straightforward strategy is proposed to fabricate hydrogel sensors for detecting human motion with antifatigue fracture performance and high sensing sensitivity.The crystalline regions and orientation along the stretching direction of cellulose nanofiber@carbon nanotube nanohybrids in the hydrogels provide antifatigue fracture performance (the crack does not expand after 2000 stretching cycles, and the fatigue threshold was calculated to be 187 j/m2), which protects hydrogels from severe damage during long-term use.In addition, the microstructured surfaces of the hydrogels with a random height distribution increase the contact area and improve the response to weak stimuli, resulting in a sensing sensitivity of 1.11 k pa-1, 18 times higher than that of a flat hydrogel.This sensing sensitivity is higher than those of most of the hydrogel-based pressure sensors that have been reported earlier.By integrating antifatigue fracture performance and enhanced sensing sensitivity, biomimetic microstructured hydrogel sensors show great potential for use in future flexible electronic applications.

Journal: ACS applied materials & interfaces (2022)
Publication types: Journal Article
Efficacy of deep brain stimulation for the treatment of anorexia nervosa: a systematic review and network meta-analysis of patient-level data.

Deep brain stimulation (dbs) has been approved as a therapy for movement disorders and obsessive-compulsive disorder.Recently, dbs has been studied in patients with anorexia nervosa (an), which is a debilitating and life-threatening psychiatric disorder.Several stimulation locations have been tested without a clear indication of the best region.In this systematic review and network meta-analysis, the authors used patient-level data to identify stimulation targets with the greatest evidence for efficacy in increasing body mass index (bmi).Methods a systematic search was performed on or before august 4, 2022, using pub med/medline, ovid, and scopus.Articles were included if patient-level data were presented, patients were diagnosed with an and treated with dbs, and 6 months or more of postoperative follow-up data were reported.Quality and risk of bias were assessed with the nih assessment tools.Patient data were collected and stratified by stimulation location.A network meta-analysis was performed.This review was written in accordance with prisma guidelines for systematic reviews.Results eleven studies consisting of 36 patients were included.The mean age and bmi at the time of surgery were 38.07 (sd 11.64) years and 12.58 (sd 1.4) kg/m2, respectively.After 6 months of dbs, a significant difference in percentage change in bmi was found between the nucleus accumbens and subcallosal cingulate cortex (scc) (smd 0.78; 95% ci 0.10, 1.45) and between the scc and ventral anterior limb of the internal capsule (smd -1.51; 95% ci -2.39, -0.62).Similarly, at 9-12 months, a significant difference in percentage change in bmi was found between the scc and ventral anterior limb of the internal capsule (smd -1.18; 95% ci -2.21, -0.15).With hierarchical ranking, this study identified scc as the most supported stimulation location for bmi change at 6 and 9-12 months (p-scores 0.9449 and 0.9771, respectively).Conclusions several dbs targets have been tested for an, and this study identified the scc as the most supported region for bmi change.However, further studies with blinded on/off periods are necessary to confirm this finding.

Journal: Neurosurgical focus (2023)
Publication types: Meta-Analysis;Systematic Review;Journal Article
Comparative and predictive phylogeography in the South American diagonal of open formations: Unravelling the biological and environmental influences on multitaxon demography.

Phylogeography investigates historical drivers of the geographical distribution of intraspecific lineages.Particular attention has been given to ecological, climatic and geological processes in the diversification of the neotropical biota.Several species sampled across the south american diagonal of open formations (dof), comprising the caatinga, cerrado and chaco biomes, experienced range shifts coincident with quaternary climatic changes.However, comparative studies across different spatial, temporal and biological scales on dof species are still meagre.Here, we combine phylogeographical model selection and machine learning predictive frameworks to investigate the influence of pleistocene climatic changes on several plant and animal species from the dof.We assembled mitochondrial/chloroplastic dna sequences in public repositories and inferred the demographic responses of 44 species, comprising 70 intraspecific lineages of plants, lizards, frogs, spiders and insects.We then built a random forest model using biotic and abiotic information to identify the best predictors of demographic responses in the pleistocene.Finally, we assessed the temporal synchrony of species demographic responses with hierarchical approximate bayesian computation.Biotic variables related to population connectivity, gene flow and habitat preferences largely predicted how species responded to pleistocene climatic changes, and demographic changes were synchronous primarily during the middle pleistocene.Although 22 (~31%) lineages underwent demographic expansion, presumably associated with the spread of aridity during the glacial pleistocene periods, our findings suggest that nine lineages (~13%) exhibited the opposite response due to taxon-specific attributes.

Journal: Molecular ecology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Topological insulator vertical-cavity laser array.

Topological insulator lasers are arrays of semiconductor lasers that exploit fundamental features of topology to force all emitters to act as a single coherent laser.In this study, we demonstrate a topological insulator vertical-cavity surface-emitting laser (vcsel) array.Each vcsel emits vertically, but the in-plane coupling between emitters in the topological-crystalline platform facilitates coherent emission of the whole array.Our topological vcsel array emits at a single frequency and displays interference, highlighting that the emitters are mutually coherent.Our experiments exemplify the power of topological transport of light: the light spends most of its time oscillating vertically, but the small in-plane coupling is sufficient to force the array of individual emitters to act as a single laser.

Journal: Science (New York, N.Y.) (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
High Yes-associated protein 1 with concomitant negative LATS1/2 expression is associated with poor prognosis of advanced gastric cancer.

The hippo pathway is a tumour-suppressive pathway and its inactivation is known to be associated with progression and metastasis of various cancers.Lats1/2 (large tumour suppressor homolog 1 and 2), yap1 (yes-associated protein 1), and tead4 (tea domain-containing sequence-specific transcription factors 4) are core components of the hippo pathway, and their prognostic roles have not yet been studied in advanced gastric cancers (agcs).A total of 318 surgically resected agcs were retrieved.Immunolabelling for lats1/2, yap1 and tead4 was compared with clinicopathological factors including patients' survival.High expression of yap1 and tead4 was identified in 108 (34.0%) and 131 (41.2%) cases, respectively, and 223 (70.1%) cases were negative for lats1/2 expression.High yap1 expression was significantly correlated with the presence of perineural invasion (p=0.032).High yap1 and high tead4 expressions were significantly associated with poor overall survival (p<0.001 and p=0.003, respectively), and negative lats1/2 expression was also associated with poor overall survival (p=0.002).Combined expression of yap1high lats1/2negshowed the worst overall survival (p<0.001).Expression of yap1high(hr=2.938; 95% ci 1.726-4.998; p<0.001), lats1/2neg(hr=0.371; 95% ci 0.181-0.758; p=0.007), and combined yap1high lats1/2neg(hr=13.785; 95% ci 3.245-58.554; p<0.001) were independent poor prognostic factors of agc patients.Combined or individual expression of yap1, lats1/2, and tead4 can be used as prognostic markers of agc patients.

Journal: Pathology (2019)
Publication types: Journal Article
Review: Selecting for improved feed efficiency and reduced methane emissions in dairy cattle.

It may be possible for dairy farms to improve profitability and reduce environmental impacts by selecting for higher feed efficiency and lower methane (ch4) emission traits.It remains to be clarified how ch4 emission and feed efficiency traits are related to each other, which will require direct and accurate measurements of both of these traits in large numbers of animals under the conditions in which they are expected to perform.The ranking of animals for feed efficiency and ch4 emission traits can differ depending upon the type and duration of measurement used, the trait definitions and calculations used, the period in lactation examined and the production system, as well as interactions among these factors.Because the correlation values obtained between feed efficiency and ch4 emission data are likely to be biased when either or both are expressed as ratios, therefore researchers would be well advised to maintain weighted components of the ratios in the selection index.Nutrition studies indicate that selecting low emitting animals may result in reduced efficiency of cell wall digestion, that is ndf, a key ruminant characteristic in human food production.Moreover, many interacting biological factors that are not measured directly, including digestion rate, passage rate, the rumen microbiome and rumen fermentation, may influence feed efficiency and ch4 emission.Elucidating these mechanisms may improve dairy farmers ability to select for feed efficiency and reduced ch4 emission.

Journal: Animal : an international journal of animal bioscience (2018)
Publication types: Journal Article;Review
Probing the Origin of Ferro-/Antiferromagnetic Exchange Interactions in Cu(II)-4f Complexes.

The mechanistic investigations between cu(ii) and the anisotropic lanthanides (ln(iii)) are not much explored to date.This is due to the complicated energy spectrum which arises due to the orbital angular momentum of anisotropic lanthanides.Interestingly, the exchange coupling jin ln(iii)-cu(ii) systems was found to be antiferromagnetic for 5-tb(1.18(10) cm-1) >6-dy(0.56(10) cm-1based on the-2jcu-ln(scu1→·jlnz→+scu2→·jlnz→)spin hamiltonian.The increased axiality in5-tband6-dydue to the presence of 3d ions in the near vicinity of an oblate ion and the increased exchange coupling strength between cu(ii) and tb(iii) or dy(iii) is the ideal combination to stabilize magnetic bistability in these complexes in the absence of an external magnetic field with the effective energy barrier of 15.7 k (τo= 2.49 × 10-6s) and 12.6 k (τo= 1.70 × 10-5s), respectively.To rationalize this experimental trend, we have performedab initio casscf and dft calculations.To compute the jvalues, we have employed poly_aniso routines and utilized the computed data to establish the generic mechanism of magnetic coupling in {cu-ln-cu} motifs.These mechanistic findings reveal the importance of 5d orbitals and their energy with respect to the dx2-y2orbital of cu(ii) ions in controlling the magnetic coupling of {cu-4f} complexes.

Journal: Inorganic chemistry (2022)
Publication types: Journal Article
The analgesic benefit of Pericapsular Nerve Group (PENG) block in hip arthroscopic surgery: a retrospective pragmatic analysis at an academic health center.

Introduction the novel pericapsular nerve group (peng) block has recently been reported to provide effective motor-sparing local anesthetic-based analgesia to the hip joint.We aimed to evaluate the analgesic efficacy and safety of a preoperative peng block among patients undergoing ambulatory hip arthroscopic surgery where systemic analgesia is the gold standard.Methods we conducted a single-center, retrospective pragmatic exploratory cohort study of consecutive outpatient hip arthroscopic surgery cases from january 2017 to march 2019.We identified 164 cases in which patients received general anesthesia with or without a preoperative peng block.The primary analgesic outcome measures were time to first postoperative analgesic request, intraoperative and postoperative opioid consumption (intravenous morphine equivalent), and postoperative pain severity (visual analog scale 10 cm scale ranging from 0=no pain to 10=severe pain) in hospital.Secondary outcomes included duration of stay in the postanesthesia care unit, opioid-related side effects, time to discharge readiness, and block-related complications.Results seventy-five cases received a preoperative peng block and 89 cases received systemic analgesia alone.The addition of a peng block reduced intraoperative (6.6 mg vs 7.5 mg, difference: 0.9 mg; 95% ci 0.2 to 1.7; p=0.01) and postoperative (10.7 mg vs 13.9 mg, difference: 3.2 mg; 95% ci 0.9 to 5.5; p=0.01) intravenous morphine consumption, as well as the mean (3.5 vs 4.2, difference: 0.7; 95% ci 0.1 to 1.3; p=0.03) and highest (5.5 vs 6.5, difference: 1.0; 95% ci 0.2 to 1.7; p=0.02) postoperative pain severity scores in hospital.The peng block did not prolong the time to first analgesic request (15.8 min vs 12.3 min, difference: 3.5 min; 95% ci -9.0 to 2.0; p=0.23).Fewer patients in the peng group experienced postoperative nausea and vomiting compared with systemic analgesia alone (36% vs 52%, or 1.9; 95% ci 1.0 to 3.6; p=0.02), while the peng block expedited discharge readiness (165.0 min vs 202.8 min, difference: 37.8 min; 95% ci 2.9 to 72.3; p=0.04).No block-related complications were noted in any patient.Discussion based on our retrospective dataset, this pragmatic exploratory cohort study suggests that a preoperative peng block is associated with questionable improvements in postoperative in-hospital analgesic outcomes which may or may not prove to be clinically relevant when compared with systemic analgesia alone for patients undergoing hip arthroscopic surgery.This small signal should be investigated in a prospective randomized trial.

Journal: Regional anesthesia and pain medicine (2022)
Publication types: Journal Article