syedzayyan/paper_mill_benchmark huggingface dataset:
Postpartum Reversible Cerebral Vasoconstriction Syndrome Presenting with Radiological Plethora.

Reversible cerebral vasoconstriction syndrome (rcvs) is a clinicoradiological syndrome characterized by segmental vasoconstriction of cerebral arteries with resolution in most patients within 1 to 3 months.It has been known to be a benign uniphasic reversible illness but cases of fulminant rcvs with mortality have also been reported.The symptoms can be varied with presentations like transient ischemic attack (tia), ischemic stroke (is), intracerebral hemorrhage (ich), subarachnoid hemorrhage (sah), and posterior reversible encephalopathy syndrome (pres).We report a postpartum female with rcvs with radiological features of ich, sah, atypical pres, and atypical clinical presentation as well.Rcvs can be frequently missed unless there is a high index of suspicion.Hence clinicians should be aware of the typical and the atypical presentation of rcvs along with the radiological findings with the potential complications.Early suspicion and detection in the emergency help in recovery and reducing morbidity.

Journal: The Indian journal of radiology & imaging (2021)
Publication types: Case Reports;Journal Article
EVI1 promotes metastasis by downregulating TIMP2 in metastatic colon and breast cancer cells.

Ecotropic viral integration site-1 (evi1) is an oncogenic zinc finger transcription factor whose expression is frequently upregulated in a variety of cancers, including both myeloid malignancies and solid tumors.Previously, our group has shown that evi1 knockdown minimizes the metastatic potential of colon cancer cells compared to that of control cells.In this study, to identify the potential targets that regulate cancer metastasis, control and evi1 knockdown colon cancer cells were subjected to microarray.Differential gene expression analysis revealed significant downregulation of tissue inhibitor of matrix metalloproteinase-2 (timp2) in evi1 expressing cells.Evi1 knockdown increased timp2 protein expression levels and reduced wound healing and migration capacity in metastatic cells.Mechanistically, the timp2 promoter harbors potential binding sites for evi1; evi1 binds to timp2 promoter and represses its expression, as observed using ch ip and luciferase assay, respectively.Timp2 is an important metastasis suppressor gene; however, its function is suppressed in many cancers through hypermethylation.Thus, demethylation could prove to be a potential alternative to reactivate timp2 functional activity.Immunoprecipitation analysis showed that dna-methyltransferase 1 (dnmt1), which plays a vital role in maintaining the genome methylation pattern during dna replication and repair, interacts with evi1 to promote timp2 silencing.Treating cancer cells in vitro with a known demethylation agent, 5-aza-2'-deoxycytidine (aza-d), restored the optimal timp2 expression without altering evi1 binding efficiency and reduced relative wound healing potential of cancer cells.Animal studies showed that aza-d treated cells injected through the intravenous route exhibited reduced liver and skin metastasis when compared to non-treated cells.Furthermore, aza-d treatment in mice delayed the metastasis progression compared to the vehicle treated group.Thus, the present study provides an insight into the therapeutic applications of demethylating agents to reduce cancer metastasis in models with evi1 overexpressing tumors.

Journal: The international journal of biochemistry & cell biology (2022)
Publication types: Journal Article
Multimedia Cryptosystem for IoT Applications Based on a Novel Chaotic System around a Predefined Manifold.

Multimedia data play an important role in our daily lives.The evolution of internet technologies means that multimedia data can easily participate amongst various users for specific purposes, in which multimedia data confidentiality and integrity have serious security issues.Chaos models play an important role in designing robust multimedia data cryptosystems.In this paper, a novel chaotic oscillator is presented.The oscillator has a particular property in which the chaotic dynamics are around pre-located manifolds.Various dynamics of the oscillator are studied.After analyzing the complex dynamics of the oscillator, it is applied to designing a new image cryptosystem, in which the results of the presented cryptosystem are tested from various viewpoints such as randomness, time encryption, correlation, plain image sensitivity, key-space, key sensitivity, histogram, entropy, resistance to classical types of attacks, and data loss analyses.The goal of the paper is proposing an applicable encryption method based on a novel chaotic oscillator with an attractor around a pre-located manifold.All the investigations confirm the reliability of using the presented cryptosystem for various io t applications from image capture to use it.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article
Clinical features and treatment outcomes of pulmonary actinomycosis.

Pulmonary actinomycosis is a rare and chronic infectious disease that mimics malignancy and is frequently misdiagnosed.There are few reports that address the clinical characteristics of pulmonary actinomycosis.The objective of this research is to evaluate the clinical features, radiological findings, diagnostic approaches and treatment outcomes of pulmonary actinomycosis.Patients and methods thirty-seven patients with pulmonary actinomycosis histopathologically diagnosed from 2009 to 2021 were analyzed retrospectively.Results the mean age at presentation was 53.7 (±13.3) years.Frequent symptoms were cough and hemoptysis.The median diagnosis time from the first symptoms was 60 days (interquartile range 18-195).Pulmonary comorbidity was found in 59.5% of cases.The most common thorax computed tomography finding was mass or nodule.The low-attenuation center within the mass or consolidation was observed in 40% of the lesions.The median maximal standardized uptake value of lesions on positron emission tomography (pet) was 6.5 (interquartile range 2.7-10.3).In the majority of cases (97.3%), the diagnosis of pulmonary actinomycosis was not suspected at admission, and 56.8% of patients were misdiagnosed with lung cancer.The mean duration of antibiotic therapy was 9.4 days (range 3-22) with intravenous antibiotics and 64.7 days (range 5-270) with oral antibiotics.Four patients died due to concomitant comorbidities.Eight cases were lost to follow-up.All other cases were fully cured.Conclusions pulmonary actinomycosis mimics other diseases, often lung cancer.Clinicians should consider the diagnosis of actinomycosis when they detect a mass or consolidation, especially with a low-attenuation center.Pet/ct appears not to be useful for differential diagnosis.A shorter course of antibiotic therapy than traditionally recommended appears to be sufficient.

Journal: European review for medical and pharmacological sciences (2022)
Publication types: Journal Article
Evaluation of Hepatoprotective Potential of Polyherbal Preparations in CCl4-Induced Hepatotoxicity in Mice.

Polyherbal formulations (plfs) have been widely used for liver protection, treatment for hepatic dysfunction, and regeneration.They can also enhance appetite and protect the gastrointestinal tract from injury.In spite of the prevalent use, there is a need of scientific evidence on their effectiveness and safety.The objective of the present study was to assess the hepatoprotective effect of polyherbal formulations (commercially available in bangladesh namely heptaliv, holyliv, icturn, and j-deenar) in ccl4-induced hepatotoxicity in mice.Methods in this study, swiss albino mice were treated for 7 days with distilled water or plfs (2.6 and 5.2 ml/kg body weight/day, per os.) followed by single subcutaneous injection of ccl4(1 ml/kg body weight, diluted with olive oil in 1 : 1 ratio) on day 8.Twenty-four hours after ccl4administration, the mice were monitored for the effects of plfs on liver morphology, biochemical parameters including serum aspartate transaminase (ast), serum alanine transaminase (alt), alkaline phosphatase (alp), and total bilirubin.Phenobarbitone-induced sleeping time and histopathology changes in liver tissues were also monitored.Results ccl4administration caused significant hepatotoxicity as evidenced by marked elevation in ast, alt, alp, and total bilirubin.Phenobarbitone-induced sleeping time and infiltration of inflammatory cells and centrizonal necrosis on histological examination of liver demonstrated hepatic injury after ccl4administration.However, the administration of icturn and j-deenar polyherbal formulations at the higher dose significantly decreased the levels of ast, alt, alp, and total bilirubin.Moreover, pentobarbitone-induced sleeping time and histopathological analysis also revealed significant improvement as result of treatment with formulations icturn and j-deenar.Conclusion our results confirmed that polyherbal formulations (icturn and j-deenar) can significantly prevent ccl4-induced hepatotoxicity in mice, demonstrating their protective effect for liver.

Journal: Advances in pharmacological and pharmaceutical sciences (2022)
Publication types: Journal Article
PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption.

Pik3ca-related overgrowth syndrome (pros) is a genetic disorder caused by somatic mosaic gain-of-function mutations of pik3ca.Clinical presentation of patients is diverse and associated with endocrine disruption.Adipose tissue is frequently involved, but its role in disease development and progression has not been elucidated.Here, we created a mouse model of pik3ca-related adipose tissue overgrowth that recapitulates patient phenotype.We demonstrate that pik3camutation leads to glut4 membrane accumulation with a negative feedback loop on insulin secretion, a burst of liver igfbp1 synthesis with igf-1 sequestration, and low circulating levels.Mouse phenotype was mainly driven through akt2.We also observed that pik3camutation induces metabolic reprogramming with warburg-like effect and protein and lipid synthesis, hallmarks of cancer cells, in vitro, in vivo, and in patients.We lastly show that alpelisib is efficient at preventing and improving pik3ca-adipose tissue overgrowth and reversing metabolomic anomalies in both animal models and patients.

Journal: Science advances (2022)
Publication types: Journal Article
Perspectives on glucocorticoid treatment for COVID-19: a systematic review.

Coronavirus disease 2019 (covid-19) is a viral pneumonia that can lead to acute respiratory distress syndrome (ards).Until the commercialization of a vaccine, pharmacological treatment still represents an important strategy to fight against the ongoing pandemic.Glucocorticoids (gc) were widely used in the past coronavirus pandemics and have been used against the coronavirus 2 severe acute respiratory syndrome (sars-co v-2).This article aimed to review the studies that described the treatment with gc in covid-19 patients.Randomized or nonrandomized clinical trials and retrospective or prospective-controlled longitudinal studies were screened for this systematic review.Studies in english, portuguese, and spanish published since 2019, with participants of any clinical status, geographic location, age, and sex were included.The most significant interest was related to the length of stay, radiological profile changes, viremia, and mortality.The research was done electronically on the pubmed database using the following terms: "corticosteroids", "glucocorticoids", "dexamethasone", "methylprednisolone", "covid-19", "sars- co v-2", "adrs".We identified 6332 publications, and at the end, 14 retrospective observational studies that met all the inclusion criteria were selected.These studies included only patients infected with sars-co v-2 confirmed by rt-pcr, involving 2,713 participants.The results showed great heterogeneity in their designs and results, which precludes a reliable conclusion on the use of gcs in the treatment of covid-19.

Journal: Pharmacological reports : PR (2021)
Publication types: Journal Article;Systematic Review
Active-site molecular docking of nigellidine with nucleocapsid-NSP2-MPro of COVID-19 and to human IL1R-IL6R and strong antioxidant role ofNigella sativain experimental rats.

The recent outbreak of sars co v-2 has changed the global scenario of human lives/economy.A significant number of the non-survivors showed cardiac renal vasculature dysfunction.A 'cytokine storm' namely, interleukin il6-il1 receptors, i.e.Il6r-il1r over-functioning was reported.Here, nigellidine, an indazole alkaloid and key component of nigella sativa l.(ns) commonly known as black cumin seed was analysed for covid-19 protein targeting and il1r-il6r inhibition through molecular docking study and biochemical study in experimental rat to evaluate antioxidative capacity.The nmr/x-ray crystallographic/electron microscopic structures of covid-19 main protease (6lu7)/spike glycoprotein (6vsb)/nsp2 (qhd43415_2)/nucleocapsid (qhd43423), human il1r (1itb)-il6r (1pm9) from pdb were retrieved analysed for receptor-ligand interaction.Then, those structures were docked with nigellidine using auto dock and patch dock server.A brief comparison was made with nigellicine thymoquinone from n.Sativa.where nigellidine showed highest binding energy of -6.6 kcal/mol, ligand efficiency of -0.3 with covid19 nsp2 forming bonds with amino acid cys240 present in binding pocket.Nigellidine showed strong interaction with main protease (be: -6.38/le: -0.29).Nigellidine showed affinity to il1r (-6.23).The ns treated rat showed marked decline in alp-sgpt-sgot-malondialdehyde (mda) than the basal levels.From the western blot and activity analysis, it was observed that nigellidine (sulphuryl group drug) showed no impact on phenol-catalysing astiv and steroid-catalysing oestrogen-sulphotransferase expressions and activities in liver tissue and thus has no influence in sulphation-mediated adverse metabolic processes.Conclusively, nigellidine has hepato-reno-protective/antioxidant-immunomodulatory/anti-inflammatory activities with inhibit potentials of covid-19 proteins.Further validation is necessary.

Journal: Journal of drug targeting (2022)
Publication types: Journal Article
Incidence and clinical characteristics of pediatric inflammatory bowel disease in Oman.

Pediatric inflammatory bowel disease (pibd) has been documented all over the world, and there is now a large body of clinical, pathological, and treatment knowledge and protocols in place in many countries.There is currently limited knowledge on the prevalence and pathology of pibd in omani population.The aim of this study is to report the incidence and clinical features of pibd in oman.Methods this was a retrospective, cross-sectional, multicenter study carried out on all children <13 years of age between january 1, 2010 and december 31, 2021.Results fifty-one children were identified, 22 males (43.1%) and 29 females (56.9%), who were mostly from the muscat region of oman.The median incidence in the country was 0.57 (confidence interval [ci]: 0.31-0.64) per 105children for inflammatory bowel disease (ibd), 0.18 (ci: 0.07-0.38) per 105children for ulcerative colitis (uc), and 0.19 (ci: 0.12-0.33) per 105children for crohn's disease (cd).There was a significant increase in the incidence of all pibd types after the year 2015.Bloody diarrhea was the most common symptom, followed by abdominal pain.Perianal disease affected nine children (40.9%) with cd.Conclusion the incidence of pibd in oman is lower than in some neighboring gulf countries but similar to that of saudi arabia.An alarming upward trend was noted from the year 2015.Large-scale population-based studies are required to investigate the possible causes of this increasing incidence.

Journal: Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association (2023)
Publication types: Multicenter Study;Journal Article
Psychological Complications at 3 Months Following Stroke: Prevalence and Correlates Among Stroke Survivors in Lebanon.

Introduction:stroke continues to be a common and debilitating medical condition which has a significant effect on public health as the second primary source of mortality and the third major root of disability worldwide.A wide range of complications affecting the survivor's life and interfering with the recovery process usually follows stroke; anxiety and depression are considered one of the major complications post-stroke.This study sought to investigate the short-term psychological consequences of stroke among lebanese survivors and to identify their correlates.methods:this study is a prospective observational epidemiological study.143 stroke patients admitted to hospitals in mount lebanon and beirut between february and may 2018.were included in this study.Assessments of complications were carried out at 3 months post-stroke by completing a 30-min face-to-face interview questionnaire.The survey included the socio-demographic -characteristics of the patients, their lifestyle, health indicators, the severity of stroke, and the post-stroke consequences disturbing their quality of life.results:complications were recorded for 117 stroke survivors (mean age, 72.46 years; 60.7% male).The analysis of results 3 months post stroke showed that 29 survivors suffered from neuropathic pain (24.8%), 110 (94%) suffered from fatigue, and 81 (69.2%) from cognitive impairment.High rates of anxiety (51.3%), and depression (76.1%) were recorded as well.Multivariate logistic regression confirmed that there is a significant association between depression and the following variables: anxiety (or = 4.814,p-value = 0.017), pain (or = 6.868,p-value = 0.002), and physical activity, which acts as a protective factor against depression (or = 0.261;p-value = 0.029).However, the results of the multivariate logistic regression analysis for anxiety indicated that immobility-related complications increase the risk of anxiety by 8.457 in sedentary duration longer than 12 h (ora = 8.457,p-value = 0.01).Furthermore, patients with neuropathic pain (24.8%) are 3.858 times more likely to have anxiety compared to patients without neuropathic pain (ora = 3.858,p-value = 0.019).conclusion:using a patient-centered structure more interventions should take place to evaluate stroke survivors' outcomes, and organize rehabilitation services that deal with stroke consequences, particularly high anxiety and depression levels, which are prevalent and persistent among the lebanese stroke survivors.

Journal: Frontiers in psychology (2021)
Publication types: Journal Article
Phytochemical and in silico studies for potential constituents fromCentaurium spicatumas candidates against the SARS-CoV-2 main protease and RNA-dependent RNA polymerase.

In the present study, a new secoiridoid glycoside lisianthoside ii1, along with seven known compounds2-8,were isolated from centaurium spicatum l.In-silico molecular docking and molecular dynamic simulation against sars-co v-2 main protease (mpro) and rna-dependent rna polymerase (rd rp) were conducted.The affinity docking scores revealed that8is the best bound ligand to mproactive site with binding energy of -14.9877 kcal/mol (rsmd = 1.16 å), while6was the highest against rd rp (-16.9572 kcal/mol, rmsd = 1.01 å).Moreover, the molecular dynamic simulation revealed that8with a (δg) of -7.9 kcal/mol (rmsd value of 2.6 å) and6(rmsd value of 1.6 å) and binding free energy (δg) of -7.1 kcal/mol achieved the highest stability over 50 ns of mds inside the mproand rd rp enzyme's active site, respectively.Hence, the isolated compounds could be a good lead for development of new leads targeting covid-19.

Journal: Natural product research (2022)
Publication types: Journal Article
Response mechanisms to ocean warming exposure in Effrenium voratum (Symbiodiniaceae).

Ocean warming is an extreme environment event that has profound and lasting impacts on symbiodiniaceae.However, their response mechanisms to elevated temperature exposure are poorly understood.In this study, the physiological and transcriptional responses of effrenium voratum (symbiodiniaceae) to ocean warming were examined.After exposure to 30 °c, no significant variations in growth, chlorophyll a, or photosynthetic and respiration rates were observed, while a higher temperature (34 °c) significantly reduced these physiological measurements.Meanwhile, lipid content and fatty acid composition were altered at high temperature (i.e., elevated degree of fatty acid saturation).Such biochemical constituents likely contributed to the mitigation of the negative effects of elevated temperatures.Furthermore, higher expression levels of genes related to the synthesis and elongation of fatty acids were detected at high temperature.The adjustment of lipids and fatty acid composition may be a potential mechanism by which e.Voratum may survive under future global warming.One sentence summary: the adjustment of lipids and fatty acid composition may be a potential mechanism by which e.Voratum acclimate to future global warming.

Journal: Marine pollution bulletin (2022)
Publication types: Journal Article
Estimating the long-term effects of mass screening for latent and active tuberculosis in the Marshall Islands.

Ambitious population-based screening programmes for latent and active tuberculosis (tb) were implemented in the republic of the marshall islands in 2017 and 2018.Methods we used a transmission dynamic model of tb informed by local data to capture the marshall islands epidemic's historical dynamics.We then used the model to project the future epidemic trajectory following the active screening interventions, as well as considering a counterfactual scenario with no intervention.We also simulated future scenarios including periodic interventions similar to those previously implemented, to assess their ability to reach the end tb strategy targets and tb pre-elimination in the marshall islands.Results the screening activities conducted in 2017 and 2018 were estimated to have reduced tb incidence and mortality by around one-third in 2020, and are predicted to achieve the end tb strategy milestone of 50% incidence reduction by 2025 compared with 2015.Screening interventions had a considerably greater impact when latent tb screening and treatment were included, compared with active case finding alone.Such combined programmes implemented at the national level could achieve tb pre-elimination around 2040 if repeated every 2 years.Conclusions our model suggests that it would be possible to achieve tb pre-elimination by 2040 in the marshall islands through frequent repetition of the same interventions as those already implemented in the country.It also highlights the importance of including latent infection testing in active screening activities.

Journal: International journal of epidemiology (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.