syedzayyan/paper_mill_benchmark huggingface dataset:
The factors influencing the eating behaviour of shiftworkers: what, when, where and why.

Shiftwork leads to altered eating patterns, with workers often eating foods at all times across the 24 h period.Strategies to reduce the burden of shiftwork on the workers should be prioritised and altering these eating patterns is an important area for change.This narrative review examines the current evidence on the individual and environmental factors influencing the eating behaviours of shiftworkers.A systematic search was conducted and yielded 62 articles.These were split into four themes that influence eating patterns; when shiftworkers eat, what type of foods shiftworkers eat, where the food is sourced from, and why shiftworkers choose to eat on shift.Irregular working hours was the biggest influence on when workers ate on shift, shift-type was the biggest influence on what workers ate, the majority of food was sourced from canteens and cafeterias, and socialising with colleagues was the biggest reason why workers chose to eat.While more research is needed to explore multiple industries and shift-types, and to investigate the ideal size, type and timing of food on shift, this review has highlighted that future research into shiftworker eating needs to adopt an integrative approach and consider the different individual and social contexts that influence eating patterns.

Journal: Industrial health (2019)
Publication types: Journal Article;Review
A case report of melanotic neuroectodermal tumor of infancy complicated with congenital heart disease and hypothyroidism.

To the best of our knowledge, thus far there are no reported cases of melanotic neuroectodermal tumor of infancy (mnti) with multiple complications.In this case report, we describe the clinical phenotype of mnti in a 9-month-old female infant associated with tetralogy of fallot (tof), a congenital heart defect, and congenital hypothyroidism (ch).Our study showed that the growth of mnti was delayed by a lower dosage of levothyroxine (l-t4) that was prescribed to treat ch because of the presence of tof, a severe congenital heart disease.However, the standardized dosage of l-t4 improved thyroid function but stimulated the rapid growth of mnti.Our report demonstrated that treatment with l-t4 affects the progression of mnti.Our findings demonstrated the role of thyroid hormone in mnti growth and progression.Furthermore, our study suggested that the treatment of co-morbidities in children with mnti requires careful consideration of their effects on the growth and progression of mnti.

Journal: Frontiers in cardiovascular medicine (2022)
Publication types: Case Reports;Journal Article
Love in the Time of COVID-19: A Multi-Wave Study Examining the Salience of Sexual and Relationship Health During the COVID-19 Pandemic.

The current study used family systems theory as a framework to clarify the impact of the covid-19 pandemic on sexual, romantic, and individual functioning.Specifically, sexual and romantic functioning were modeled as key mechanisms linking covid-19 related stressors (as predictors) to aspects of individual functioning over time (as outcomes).A sample of 1,241 sexually active adults in relationships (47% married/engaged) was recruited from march 5 to may 5, 2020: 82% white, 66% women, m = 34 years old, 58% heterosexual.All participants completed a baseline survey and 642 participants completed at least one of the six, monthly, follow-up surveys.Multilevel sem models evaluated the model both at the level of stable between-person differences (i.e., level 2) and at the level of within-person change across time (i.e., level 1).The findings suggested that covid-19 related stress was predictive of lower sexual, romantic, and individual functioning in both levels of the model.Significant indirect paths supported the proposed mediation at the level of within-person change across time: elevations in covid-19 stress within specific months predicted corresponding drops in sexual functioning, which in turn predicted corresponding drops in romantic functioning, which in turn predicted corresponding drops in individual well-being (highlighting points of intervention).In contrast, at the level of between-person differences, stable levels of sexual and relationship satisfaction across the 6 months of the study were not associated with stable levels of covid-19 stressors (representing sources of resilience that promoted well-being) and stable levels of stress from social isolation predicted stably higher amounts of communicating affection to one's loved ones (suggesting a need for affiliation in the face of chronic stress) whereas stable difficulties with orgasms were linked to stable irritability toward partners and depressive symptoms.Multigroup analyses suggested that the findings generalized across gender, age, race/ethnicity, sexual orientation, relationship stage, and cohabitation groups.Spillover effects within a family systems theory framework clarify how upheaval of the covid-19 pandemic could have impacted sexual, romantic, and individual functioning in a process-oriented framework, highlighting sources of resilience (sexual satisfaction, communicating affection) and risk (orgasm difficulties).

Journal: Archives of sexual behavior (2022)
Publication types: Journal Article
De novo genome assembly of Bacillus altitudinis 19RS3 and Bacillus altitudinis T5S-T4, two plant growth-promoting bacteria isolated from Ilex paraguariensis St. Hil. (yerba mate).

Plant growth-promoting bacteria (pgpb) are a heterogeneous group of bacteria that can exert beneficial effects on plant growth directly or indirectly by different mechanisms.Pgpb-based inoculant formulation has been used to replace chemical fertilizers and pesticides.In our previous studies, two endophytic endospore-forming bacteria identified as bacillus altitudinis were isolated from roots of ilex paraguariensis st.Hil.Seedlings and selected for their plant growth-promoting (pgp) properties shown in vitro and in vivo.The purposes of this work were to assemble the genomes of b.Altitudinis 19rs3 and t5s-t4, using different assemblers available for windows and linux and to select the best assembly for each strain.Both genomes were also automatically annotated to detect pgp genes and compare sequences with other genomes reported.Library construction and draft genome sequencing were performed by macrogen services.Raw reads were filtered using the trimmomatic tool.Genomes were assembled using spades, aby ss, velvet, and soapdenovo2 assemblers for linux, and geneious and clc genomics workbench assemblers for windows.Assembly evaluation was done by the quast tool.The parameters evaluated were the number of contigs ≥ 500 bp and ≥ 1000 bp, the length of the longest contig, and the n50 value.For genome annotation prokka, rast, and kaas tools were used.The best assembly for both genomes was obtained using velvet.The b.Altitudinis 19rs3 genome was assembled into 15 contigs with an n50 value of 1,943,801 bp.The b.Altitudinis t5s-t4 genome was assembled into 24 contigs with an n50 of 344,151 bp.Both genomes comprise several genes related to pgp mechanisms, such as those for nitrogen fixation, iron metabolism, phosphate metabolism, and auxin biosynthesis.The results obtained offer the basis for a better understanding of b.Altitudinis 19rs3 and t5s-t4 and make them promissory for bioinoculant development.

Journal: PloS one (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A Case of a Pregnant Woman With Primary Aldosteronism and Superimposed Preeclampsia Treated With Esaxerenone.

During pregnancy, there is no established treatment for idiopathic hyperaldosteronism (iha), the most common form of primary aldosteronism due to bilateral adrenal hyperplasia.Here, we report the case of a pregnant patient with iha who was successfully treated with esaxerenone, a nonsteroidal mineralocorticoid receptor (mr) antagonist.A 39-year-old woman was diagnosed with iha and commenced on nifedipine 20 mg daily because she desired to be pregnant.After 1 year, she became pregnant.Her blood pressure was well controlled until 34 weeks of gestation when her home blood pressure became elevated up to 140/90 mm hg.Although the dose of nifedipine was increased to 80 mg daily, her blood pressure increased to 151/97 mm hg, and urinary test showed proteinuria of 2+ in 35 weeks of gestation.She was diagnosed with superimposed preeclampsia (spe) and additionally treated with esaxerenone.Her blood pressure decreased to 120-140/98-100 mm hg and the proteinuria improved to ±.A successful cesarean section at 37 weeks resulted in the delivery of a healthy baby boy.Her blood pressure was well controlled although esaxerenone was discontinued 2 weeks after the delivery.This is the first case of a pregnant woman who was safely treated with esaxerenone despite being a female at advanced maternal age who had been diagnosed with iha and developed spe.Further studies are needed to investigate the efficacy and safety of nonsteroidal selective mr antagonist in similar pregnant patients with iha to establish better treatment strategy for these patients.

Journal: Journal of the Endocrine Society (2022)
Publication types: Case Reports;Journal Article
Genomics landscape of 185 Streptococcus thermophilus and identification of fermentation biomarkers.

Streptococcus (s.) thermophilus, an indispensable dairy starter, has been used in autochthonous as well as industrial milk fermentation.However, the genetic architecture underlying s.Thermophilus traits and phenotypes is largely unknown.Here, we sequenced 185 s.Thermophilus strains, isolated from natural fermented dairy products of china and mongolia and used comparative genomic and genome wide association study to provide novel point for genetic architecture underlying its traits and phenotypes.Genome analysis of s.Thermophilus showed association of phylogeny with environmental and phenotypic features and revealed clades with high acid production potential or with substantial genome decay.A few s.Thermophilus isolated from areas with high chloramphenicol emissions had a chloramphenicol-resistant gene cat b8.Most importantly, we defined a growth score and identified a missense mutation g1118698t located at the gene acn a that were both predictive of acidification capability of s.Thermophilus.Our findings provide novel insight in s.Thermophilus genetic traits, antibiotic resistant and predictive of acidification capability which both may had huge help in culture starter screening.

Journal: Food research international (Ottawa, Ont.) (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Controlling gene expression with light: a multidisciplinary endeavour.

The expression of a gene to a protein is one of the most vital biological processes.The use of light to control biology offers unparalleled spatiotemporal resolution from an external, orthogonal signal.A variety of methods have been developed that use light to control the steps of transcription and translation of specific genes into proteins, for cell-free to in vivo biotechnology applications.These methods employ techniques ranging from the modification of small molecules, nucleic acids and proteins with photocages, to the engineering of proteins involved in gene expression using naturally light-sensitive proteins.Although the majority of currently available technologies employ ultraviolet light, there has been a recent increase in the use of functionalities that work at longer wavelengths of light, to minimise cellular damage and increase tissue penetration.Here, we discuss the different chemical and biological methods employed to control gene expression, while also highlighting the central themes and the most exciting applications within this diverse field.

Journal: Biochemical Society transactions (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Comparison between joystick- and gaze-controlled electric wheelchair during narrow doorway crossing: Feasibility study and movement analysis.

Due to motor deficiencies inducing low force capabilities or tremor, many persons have great difficulties to use joystick-operated wheelchairs.To alleviate such difficulties, alternative interfaces using vocal, gaze, or brain signals are now becoming available.While promising, these systems still need to be evaluated thoroughly.In this framework, the aims of this study are to analyze and evaluate the behavior of 11 able-bodied subjects during a navigation task executed with gaze or joystick-operated electric wheelchair involving a door crossing.An electric wheelchair was equipped with retroreflective markers, and their movements were recorded with an optoelectronic system.The gaze commands were detected using an eye tracking device.Apart from classical, forward, backward, stop, left and right commands, the chosen screen-based interface integrated forward-right and forward-left commands.The global success rate with the gaze-based control was 80.3%.The path optimally ratio was 0.97 and the subject adopted similar trajectories with both systems.The results for gaze control are promising and highlight the important utilization of the forward-left and forward-right commands (25% of all issued commands) that may explain the similarity between the trajectories using both interfaces.

Journal: Assistive technology : the official journal of RESNA (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Elevated Levels of Circulating Biomarkers Related to Leaky Gut Syndrome and Bacterial Translocation Are Associated With Graves' Disease.

A growing number of studies have found dysbiosis of the intestinal microbiota in patients with graves' disease (gd).The intestinal epithelial barrier serves as the first line of defense, protecting the immune system from excessive stimulation of microbiota and toxins.Most autoimmune diseases are associated with a gut barrier dysfunction (leaky gut) which allows bacterial translocation.However, to date, potential correlations between intestinal barrier dysfunction and gd have not been explored.Methods serum lipopolysaccharide (lps), intestinal fatty acid-binding protein (i-fabp), zonulin, d-lactate, and diamine oxidase (dao) were measured to assess barrier integrity in 91 patients with gd (61 initial gd and 30 euthyroid gd) and 44 healthy controls.The quality of life (qol) of patients with gd was assessed using the thyroid-specific patient-reported outcome (thy pro-39) questionnaire.Results the serum levels of lps, i-fabp, zonulin, and d-lactate were significantly higher in patients with initial gd than in healthy controls.Logistic regression analysis revealed that zonulin and d-lactate were independently associated with risk for gd and circulating zonulin could effectively distinguish patients with initial gd from healthy controls.Correlation analyses showed that i-fabp, lps, and d-lactate were positively associated with ft4 and negatively associated with tsh.In addition, circulating lps, zonulin, and d-lactate levels were all independent predictors of trab levels.Moreover, higher circulating lps levels in patients with gd were associated with more severe hyperthyroidism (higher concentrations of ft3, ft4, and trab and lower tsh concentrations) and worse scores of hyperthyroid and eye symptoms.Conclusion patients with initial gd show a disrupted intestinal barrier, characterized by elevated levels of leaky gut biomarkers.Increased intestinal permeability and bacterial translocation were associated with trab levels and hyperthyroidism in gd.Further research is required to elucidate the underlying mechanisms.

Journal: Frontiers in endocrinology (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Inpatient rehabilitation of working-age adults with ischemic stroke: comparing men and women clinical and functional characteristics at admission and predicting functionality.

Introduction the role of gender in functional independence for activities of daily living after ischemic stroke is still controversial.We aim to a) compare clinical characteristics of men and women at inpatient rehabilitation admission b) compare their functional independence at admission and discharge c) identify predictors of functional independence.Materials and methods retrospective observational cohort study.State-of-the-art variables were used for admission and discharge comparisons and to predict total fim (functional independence measure) at discharge, fim gain, fim efficiency and fim effectiveness using multivariate linear regressions.Results 144 patients (33% women) admitted to inpatient rehabilitation in a spanish specialized center, with less than 3 weeks since ischemic stroke onset were included.Men were older (p = 0.039), 19.6% of men had diabetes mellitus (6.4% of women) (p = 0.038), with 52.6% of men being non-smokers (72.3% of women) (p = 0.022).No significant differences were observed in fim at admission, discharge, fim gain, efficiency or effectiveness (total, motor either cognitive fim).Regression analysis identified sex (ß = -0.13), stroke severity (ß = -0.25) and admission total fim (ß = -0.69) as significant predictors of total fim gain (r2 = 0.42).The same variables predicted discharge total fim: sex (ß = -0.12), severity (ß = -0.23) and admission total fim (ß = 0.59) (r2 = 0.51).Fim efficiency was predicted by admission total fim (ß = -0.64), severity (ß = -0.24), age (ß = -0.17) and length of stay (ß = -0.45) (r2 = 39.9%).Fim effectiveness model explained only 13.5% of the variance.Conclusions no functional differences between men and women in any independence measure were found.Sex was a significant predictor but leaving half of the variance unexplained.

Journal: Revista de neurologia (2022)
Publication types: Journal Article;Observational Study
Genetic diversity analysis of Dermacentor nuttalli within Inner Mongolia, China.

Ticks (arthropoda, ixodida), after mosquitoes, are the second most prevalent vector of infectious diseases.They are responsible for spreading a multitude of pathogens and threatening the health and welfare of animals and human beings.However, given the history of tick-borne pathogen infections in the inner mongolia autonomous region of china, surprisingly, neither the genetic diversity nor the spatial distribution of haplotypes within ticks has been studied.Methods we characterized the haplotype distribution of dermacentor nuttalli in four main pastoral areas of the inner mongolia autonomous region, by sampling 109 individuals (recovered from sheep) in april-august 2019.The 16s r rna gene, cytochrome c oxidase subunit i (coi), and the internal transcribed spacer 2 region (its2) were amplified and sequenced from extracted dna.Results twenty-six haplotypes were identified using 16s r rna sequences, 57 haplotypes were identified with coi sequences, and 75 haplotypes were identified with its2 sequences.Among the three genes, total haplotype diversity was greater than 0.7, while total nucleotide diversity was greater than 0.06.Neutrality tests revealed a significantly negative tajima's d result, while fu's fs was not significantly positive.Fixation index values (fst) indicated that the degree of genetic differentiation among some sampled populations was small, while for others it was moderate.Analysis of molecular variance (amova) revealed that the variation within populations was greater than that among populations.The mismatch analysis of d.Nuttalli exhibited double peaks.Conclusion the genetic diversity of d.Nuttalli populations in our region can likely adapt to different geographical environments, thereby leading to genetic diversity, and creating genetic differentiation among different populations.However, genetic differentiation is cryptic and does not form a pedigree geographical structure.

Journal: Parasites & vectors (2021)
Publication types: Journal Article
Determinants of respirable quartz exposure in farming.

The objectives of this article are to quantify personal respirable quartz exposure on sandy, sandy loam, and clay soil farms and to identify exposure determinants.The methods applied included observing and examining the variables soil type, commodity farmed, activity, process, quartz % in respirable dust, and weather variables.Multiple linear regression was used to identify determinants of respirable quartz concentration and logistic regression was applied to identify determinants of respirable quartz concentration > 50 μg.m-3(a commonly used reference value of over-exposure).The highest quartz concentration was 626 μg.m-3and 30%, 22%, and 31% of measurements were > 50 μg.m-3for sandy, sandy loam, and clay soil farms, respectively.In general, the commodities livestock farming and cereal grains as well as the activity cereal planter operator, decreased humidity on the day of measurement, the mechanical processes, and quartz % in respirable dust (in a confounding way) were associated with higher respirable quartz concentrations (p ≤ 0.10) as well as season (p = 0.14).Variables associated with quartz levels above 50 μg.m-3were cereal planter operator, increased quartz % in respirable dust, decreased humidity on day of measurement, and increased respirable dust concentration.Cereal planter operator (multivariate odds ratio (or) 4.56, 95% ci: 1.79-8.89) and levels of quartz % > 10 μg.m-3(multivariate or 6.01, 95% ci: 3.52-9.71 if quartz % > 10 but ≤ 20 μg.m-3, and multivariate or 5.32, 95% ci: 2.56-8.34 if quartz % > 20 μg.m-3) were clear determinants of quartz over-exposure.It can therefore be concluded that over-exposure to quartz in farming is possible.Joint influences of more farming characteristics and weather variables should be included, together with soil type in future farming exposure assessments.

Journal: Journal of occupational and environmental hygiene (2018)
Publication types: Journal Article
Uncertainties in Atomic Data for Modeling Astrophysical Charge Exchange Plasmas.

Relevant uncertainties of theoretical atomic data are vital to determining the accuracy of plasma diagnostics in a number of areas, including, in particular, the astrophysical study.We present a new calculation of the uncertainties on the present theoretical ion-impact charge exchange atomic data and x-ray spectra, based on a set of comparisons with the existing laboratory data obtained in historical merged-beam, cold-target recoil-ion momentum spectroscopy, and electron beam ion traps experiments.The average systematic uncertainties are found to be 35-88% on the total cross sections, and 57-75% on the characteristic line ratios.The model deviation increases as the collision energy decreases.The errors on total cross sections further induce a significant uncertainty to the calculation of ionization balance for low-temperature collisional plasmas.Substantial improvements of the atomic database and dedicated laboratory measurements are needed to obtain the current models, ready for the x-ray spectra from the next x-ray spectroscopic mission.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article
Perspectives on immunometabolism at the biomaterials interface.

Productive engagement of the immune system is a persistent challenge for biomaterials scientists.Immune engineering offers a new perspective on biomaterial design, with immune cell interaction to modulate effector functions at the center.The effector functions of these cells are intimately linked to their metabolic needs and programming.Immune cell metabolism has received renewed attention in recent years, and with each new discovery there is opportunity for biomaterials scientists.This prospectus aims to provide an overview of the most recent advances in biomaterial engagement of immune cells alongside interrogation of immunometabolism, while looking to future avenues of coalescence.Four cell types are highlighted here: neutrophils, macrophages, dendritic cells, and t cells.Consideration of these two fields, and the tools within each, with a forward-looking mindset is the key to a new era of biomaterials.

Journal: Molecular aspects of medicine (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Review