syedzayyan/paper_mill_benchmark huggingface dataset:
Clinical Efficacy of Gandakang Tablets plus Methylprednisolone in Patients with Systemic Lupus Erythematosus

To evaluate the clinical efficacy of gandakang tablets plus methylprednisolone in patients with systemic lupus erythematosus (sle).Methods.From february 2015 to february 2019, 60 eligible patients with sle were recruited and assigned via the random number table method at a ratio of 1 : 1 to receive either methylprednisolone (control group) or gandakang tablets plus methylprednisolone (observation group).The primary endpoint was clinical efficacy, and the secondary endpoints included systemic lupus erythematosus disease activity index (sledai) score, immunoglobulin (ig), inflammatory factor levels, and adverse events.Results.Gandakang tablets plus methylprednisolone were associated with a significantly higher treatment efficacy versus methylprednisolone alone ( p &lt; 0.05 ).Gandakang tablets plus methylprednisolone resulted in significantly lower sledai scores and lower levels of ig g, ig m, ig a, tumor necrosis factor-α (tnf-α), interleukin-4 (il-4), and interleukin-6 (il-6) versus single medication of methylprednisolone ( p &lt; 0.05 ).The two groups showed a similar incidence of adverse events ( p &gt; 0.05 ).Patients given gandakang tablets plus methylprednisolone had higher mental health, emotional role, physical role, social functioning, and bodily pain scores versus those receiving the monotherapy of methylprednisolone ( p &lt; 0.05 ).Conclusion.Gandakang tablets plus methylprednisolone is effective in the treatment of sle by enhancing the patients’ immunity, mitigating the inflammatory response, eliminating negative emotions, and improving their quality of life.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Clinical Efficacy of Budesonide/Glycopyrronium Bromide/Formoterol in the Treatment of Patients with Acute Respiratory Distress Syndrome and Its Effect on Inflammatory Factors

To examine the clinical efficacy of budesonide/glycopyrronium bromide/formoterol (breztri aerosphere) as an adjunct to acute respiratory distress syndrome (ards).Methods.A prospective study enrolled 120 patients with pulmonary endogenous ards admitted to the department of critical care medicine at the fourth hospital of baotou from january 2017 to january 2020, and all enrollments were assigned (1 : 1) to receive conventional treatment (control group) or breztri aerosphere (study group).Results.Breztri aerosphere was associated with a significantly higher total efficacy versus conventional treatment.Breztri aerosphere resulted in significantly lower acute physiology and chronic health evaluation scoring system (apache ii) scores and murray lung injury scores versus conventional treatment.Both groups saw an increase in the partial pressure of carbon dioxide (pco2), partial pressure of oxygen (po2), and oxygen saturation (sa o2) after treatment, with higher levels seen in patients given breztri aerosphere.After treatment, systemic vascular resistance (svr) in both groups rose markedly, with greater elevation witnessed in the study group.The patients given breztri aerosphere showed significantly lower levels of pulmonary vascular resistance (pvr), mean pulmonary arterial pressure (mapa), pulmonary artery wedge pressure (pawp), interleukin-6 (il-6), interleukin-10 (il-10), tumor necrosis factor-alpha (tnf-α), and procalcitonin (pct) versus those receiving conventional treatment.The patients experienced shorter mechanical ventilation time and intensive care unit (icu) time after treatment of breztri aerosphere versus conventional treatment.Conclusion.Adjuvant therapy with breztri aerosphere in ards can significantly lower apache ii scores and murray lung injury scores, improve blood gas indexes and pulmonary circulation function indexes, and shorten mechanical ventilation time and icu time, which may be attributed to its improvement of organism inflammation status and reduction of inflammatory factors.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Clinical Efficacy and Safety of Tumor Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy for Ovarian Cancer

To assess the clinical efficacy and safety of cytoreductive surgery (crs) plus hyperthermic intraperitoneal chemotherapy (hipec) for ovarian cancer.Methods .From april 2018 to november 2021, 66 patients with ovarian cancer were admitted to our hospital and randomly allocated to undergo intravenous chemotherapy following crs (the observation group) or crs with hipec (the experimental group) using a parallel randomized technique, with 33 cases in each group.Clinical effectiveness, intraoperative and postoperative recovery, vegf level, t‐lymphocyte subpopulation cell level, adverse events, and patient survival were all outcome metrics.Results .Crs plus hipec was associated with significantly higher clinical efficacy versus crs alone ( p &lt; 0.05).The difference in the intraoperative bleeding and operative time between the two groups did not meet the statistical standard ( p &gt; 0.05).Patients in the experimental group experienced shorter postoperative chemotherapy and length of hospital stay than those in the observation group ( p &lt; 0.05).Crs plus hipec resulted in significantly lower levels of vegfa, vegfb, and vegfc and higher levels of cd3+, cd4+, and cd3+/cd4+ than crs alone ( p &lt; 0.05).The two groups of patients had a similar incidence of adverse events ( p &gt; 0.05).The experimental group showed a longer median survival (25 months) and a 1‐year survival rate (79.55%) than the observation group (22 months, 49.56%) (log rank = 20.411, p &lt; 0.05).A significantly lower 1‐year recurrence rate was observed in the experimental group than in the observation group ( p &lt; 0.05).Conclusion .Crs plus hipec effectively improves the clinical efficacy of ovarian cancer patients, prolongs the survival of patients, and improves the level of vegf and t‐lymphocyte subpopulation cells, with a manageable safety.In addition, the treatment method can improve the therapeutic effect, reduce the toxic and side effects, and improve the immunity of the body, which is worthy of clinical promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2023)
Publication types: Clinical Study;
Clinical Effect of Tongmai Fuming Decoction on Neovascular Ophthalmopathy

The incidence of neovascular eye disease is increasing year by year, seriously threatening human vision health and becoming an urgent public health problem.Tongmai fuming decoction as an experienced prescription can treat ischemic eye disease.Objective.To investigate the therapeutic effect of tongmai fuming decoction combined with anti-vegf therapy on neovascular ophthalmopathy.Methods.52 patients (62 eyes) with neovascular ophthalmopathy who met the inclusion criteria from january 2018 to july 2020 were randomly divided into the control and observation groups.The control group was given an intravitreal injection of antivascular endothelial growth factor (vegf) drugs once a day combined with on-demand treatment.The observation group was treated with traditional chinese medicine tongmai fuming decoction in addition to the treatment of anti-vegf drugs.The best-corrected visual acuity (bcva) was examined before and after treatment, and optical coherence tomography angiography (octa) was used to examine the mean retinal thickness and neovascularization in the macular area.Patients were followed for one year and the number of anti-vegf injections was recorded.Results.After treatment, the average thickness of bcva and macular retina in the two groups significantly improved.The bcva of the control group was 0.59 ± 0.39 3 months after treatment, and that of the experimental group was 0.42 ± 0.25 3 months after treatment.The average thickness of the macular retina in the control group was 304.8 ± 79.7 3 months after treatment, and that in the experimental group was 267.7 ± 64.6 3 months after treatment; the average number of injections of anti-vegf therapy in the control group was 2.32 ± 1.15 times, and that in the experimental group was 1.74 ± 0.76 times.There was a significant difference between the two groups.Conclusion.Tongmai fuming decoction and anti-vegf therapy have a synergistic effect in the treatment of neovascular ophthalmopathy, which can reduce the treatment times of anti-vegf drugs.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Classification of EEG Signal-Based Encephalon Magnetic Signs for Identification of Epilepsy-Based Neurological Disorder

Magnetoencephalography (meg) is now widely used in clinical examinations and medical research in many fields.Resting-state magnetoencephalography-based brain network analysis can be used to study the physiological or pathological mechanisms of the brain.Furthermore, magnetoencephalography analysis has a significant reference value for the diagnosis of epilepsy.The scope of the proposed research is that this research demonstrates how to locate spikes in the phase locking functional brain connectivity network of the desikan-killiany brain region division using a neural network approach.It also improves detection accuracy and reduces missed and false detection rates.The automatic classification of epilepsy encephalomagnetic signals can make timely judgments on the patient’s condition, which is of tremendous clinical significance.The existing literature’s research on the automatic type of epilepsy eeg signals is relatively sufficient, but the research on epilepsy eeg signals is relatively weak.A full-band machine learning automatic discrimination method of epilepsy brain magnetic spikes based on the brain functional connection network is proposed.The four classifiers are comprehensively compared.The classifier with the best effect is selected, and the discrimination accuracy can reach 93.8%.Therefore, this method has a good application prospect in automatically identifying and labeling epileptic spikes in magnetoencephalography.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Classification of Alzheimer’s Disease Using Gaussian-Based Bayesian Parameter Optimization for Deep Convolutional LSTM Network

Alzheimer’s disease (ad) is one of the most important causes of mortality in elderly people, and it is often challenging to use traditional manual procedures when diagnosing a disease in the early stages.The successful implementation of machine learning (ml) techniques has also shown their effectiveness and its reliability as one of the better options for an early diagnosis of ad.But the heterogeneous dimensions and composition of the disease data have undoubtedly made diagnostics more difficult, needing a sufficient model choice to overcome the difficulty.Therefore, in this paper, four different 2d and 3d convolutional neural network (cnn) frameworks based on bayesian search optimization are proposed to develop an optimized deep learning model to predict the early onset of ad binary and ternary classification on magnetic resonance imaging (mri) scans.Moreover, certain hyperparameters such as learning rate, optimizers, and hidden units are to be set and adjusted for the performance boosting of the deep learning model.Bayesian optimization enables to leverage advantage throughout the experiments: a persistent hyperparameter space testing provides not only the output but also about the nearest conclusions.In this way, the series of experiments needed to explore space can be substantially reduced.Finally, alongside the use of bayesian approaches, long short-term memory (lstm) through the process of augmentation has resulted in finding the better settings of the model that too in less iterations with an relative improvement (ri) of 7.03%, 12.19%, 10.80%, and 11.99% over the four systems optimized with manual hyperparameters tuning such that hyperparameters that look more appealing from past data as well as the conventional techniques of manual selection.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
Circular RNA SMARCA5 Modulates Epithelial-Mesenchymal Transformation, Proliferation, and Metastasis of Nasopharyngeal Carcinoma Cells via microRNA-582-3p/Phosphatase and Tensin Homolog Axis

The action mechanism in which circular rna (circ) smarca5 targeted nasopharyngeal carcinoma (npc) cell proliferation, migration, invasion, and apoptosis via micro rna (mi r)‐582‐3p/phosphatase and tensin homolog (pten) axis was explored.The examination was performed via reverse transcription‐quantitative polymerase chain reaction (rt‐q pcr), discovering that circ smarca5 was elevated while mi r‐582‐3p was silenced in npc tissues and cells.E‐cadherin and n‐cadherin were detected.The results illustrated transfection with si‐circ smarca5 or mi r‐582‐3p‐mimic was available to repress cancer cell advancement, and e‐cadherin was augmented.Transfection with pc dna 3.1‐circ smarca5 or mi r‐582‐3p‐inhibitor was available to accelerate cancer cell advancement, and n‐cadherin was augmented.Mi r‐582‐3p‐inhibitor blocked the suppression of si‐circ smarca5 on npc.The si‐pten blocked the malignant behavior of pc dna 3.1‐circ smarca5 against npc.The binding sites between circ smarca5 and mi r‐582‐3p and between mi r‐582‐3p and pten were verified.Linear analysis results illuminated the expression pattern of circ smarca5 was opposite to mi r‐582‐3p, while the expression pattern of circ smarca5 was positively associated with pten.In brief, the results of the research clarified circ smarca5 modulated npc cells’ vital movement via the mi r‐582‐3p/pten molecular axis.

Journal: Evidence-Based Complementary and Alternative Medicine (2023)
Publication types: Research Article;
circKMT2E Protect Retina from Early Diabetic Retinopathy through SIRT1 Signaling Pathway via Sponging miR-204-5p

To explore the changes of circ rnas in the retina of diabetic patients without diabetic retinopathy (dr) to screen latent protective factor.Methods.The sequencing data of the retina from three diabetic donors that possess no noticeable pathological feature of the retina at ultimate eye inspection and three healthy donative samples were involved in this study.Herein, we carried out bioinformatics analysis to disclose the expression pattern and characteristics of circ rnas on the basis of gene ontology as well as kegg pathway analyses.Then, sequencing data were applied to infer the interaction between selected circ rnas and mi r-204-5p.The potential mi rna response elements for the annotated circ rnas and their target gene were speculated using target scan as well as mi randa.Results.Rna sequencing detected 28,978 alternative circ rnas.Thereinto, 1063 were expressed with significant difference.Circ kmt2e was upregulated more than two folds in alloxan-induced diabetic retinal tissues compared with normal retinal tissues, exhibiting an expression trend opposite to mi r-204-5p.Bioinformatics analysis showed that circ kmt2e have four seed sequences on hsa-mi r-204-5p.Thus, circ kmt2e was speculated to have function on the basis of sponging mi r-204-5p in order to participate in the pathogenetic process of dr.Besides, mi r-204-5p was speculated to be able to bind sirt1, which can interact with its target proteins, and adjusts various cell functions including cellular inflammatory responses, proliferation, as well as apoptosis.Conclusion.The upregulation of circ kmt2e in the early stage of dr may be involved in its pathogenesis and may activate the sirt1 signaling pathway to protect the retina by the sponge function to mi r-204-5p.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Circ-GTF2I/miR-590-5p Axis Aggravates Myocardial Ischemia-Reperfusion Injury by Regulating Kelch Repeat and BTB Domain-Containing Protein 7

We investigated the effect of the circular rna (circ rna) general transcription factor iii (gtf2i) on myocardial ischemia (mi) deterioration and neonatal rat cardiomyocyte damage.Methods.The cell experiment was performed by using neonatal rat cardiomyocytes.Moreover, a hypoxia/reoxygenation treatment model was established.Cell counting kit-8 assay was conducted, and ed u cell proliferation was detected.Cell apoptosis was detected via flow cytometry and quantitative rt-pcr (rt-q pcr).Binding detection was performed through a double-luciferase reporter assay.Interleukin-6 (il-6), tumor necrosis factor-α (tnf-α), and lactate dehydrogenase (ldh) were detected via enzyme-linked immunosorbent assay (elisa).Results.Compared with that in the sham and control groups, circ-gtf2i expression in miri and the hypoxia/reoxygenation treatment model was significantly upregulated in vivo and in vitro.The knockdown of circ-gtf2i relieved neonatal rat cardiomyocyte damage and mi.Further detection through the double-luciferase reporter assay confirmed that the binding site of circ-gtf2i to mi r-590-5p and mi r-590-5p was kelch repeat and btb domain-containing protein 7 (kbtbd7).Elisa and rt-q pcr results showed that circ-gtf2i induced the abnormal expressions of il-6 tnf-α, ldh, bax, bcl-2, and cyt-c in miri and the hypoxia/reoxygenation treatment models by regulating mi r-590-5p and the heart development transcription factor kbtbd7.Conclusions.Circ rna circ-gtf2i aggravated miri and neonatal rat cardiomyocyte damage in vivo and in vitro by regulating mi r-590-5p and the heart development transcription factor kbtbd7.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
CircAGFG1 Promotes Osteosarcoma Progression and Stemness by Competing with miR-302a-3p to Upregulate the Expression of LATS2

This study aimed to investigate the effect of circ rna (circ agfg1) on the proliferation, migration, invasion, and cell stemness of osteosarcoma cells by targeting mi r-302a to regulate lats2.The expression of circ agfg1 in osteosarcoma cells and normal osteoblasts was detected by real-time fluorescent quantitative pcr (rt-q pcr).Cell proliferation, clone formation, and invasion were detected by cck-8, clone formation, and cell invasion assays.In vivo tumor formation assay was used to detect the effect of circ agfg1 on tumor growth.The expression level of circ agfg1 was upregulated in osteosarcoma cells.The downregulation of circ agfg1 inhibited the proliferation, invasion, and migration of osteosarcoma cells.The overexpression of circ agfg1 enhanced the stemness of osteosarcoma cells.Circ agfg1 was specifically bound to mi r-302a to regulate the expression activity of mi r-302a.Mi r-302a specifically bound to the 3′utr of lats2 and inhibited the expression of lats2.The overexpression of mi r-302a reversed the effect of circ agfg1 on the proliferation, invasion, and migration of osteosarcoma cells.Circ agfg1 regulated the expression of lats2 by mi r-302a, thereby regulating the proliferation, migration, and invasion of osteosarcoma cells.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Cinobufacini Inhibits the Development of Pancreatic Cancer Cells through the TGFβ/Smads Pathway of Pancreatic Stellate Cells

This study aimed to test cinobufacini therapeutic potential for pancreatic cancer, verify its potential molecular mechanism, and evaluate the cinobufacini impact on pancreatic cancer microenvironment.First, the effect of cinobufacini-treated pancreatic stellate cells (pscs) supernatant on the value-added ability of pancreatic cancer (pccs) was tested.The results show that cinobufacini can effectively reduce the ability of pscs supernatant to promote the value-added pccs.Further results show that cinobufacini can effectively reduce the concentration of tgfβ in the supernatant of pscs.Subsequently, the impact of cinobufacini on the transcription and translation levels of key genes in the tgfβ/smads pathway was examined.The results showed that the impact of cinobufacini on the transcription levels of smad2, smad3, and smad7 was in a concentration-dependent manner, while the transcriptional activity of collagen i m rna was decreased with the increase of cinobufacini concentration.The results of protein expression showed that cinobufacini could upregulate the expression of inhibitory protein smad7, inhibit the phosphorylation level of p-smad2/3, and then suppress the expression of type i collagen (collagen i).On the one hand, this study shows that cinobufacini can inhibit the promotion of pscs on the proliferation of pccs.On the other hand, cinobufacini can upregulate the expression of the inhibitory molecule, smad7, through the tgfβ/smads pathway and reduce the phosphorylation level of p-smad2/3, thereby inhibiting the expression of collagen i and pancreatic fibrosis.Cinobufacin can inhibit the proliferation of sw1900 cells by blocking the tgfβ/smads pathway of pancreatic stellate cells.These results provide a clinical basis for the treatment of pancreatic cancer.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Changes of Volume Parameters in the Treatment of Graves Ophthalmopathy by Endoscopic Transethmoidal Decompression of the Orbital Inner Wall Combined with Fat Decompression

To observe the orbital volume changes and the analysis of surgical effect of graves orbitopathy (go) after endoscopic medial wall decompression combined with muscle cone fat.Methods.Twenty-two patients (30 eyes) with graves orbital disease who visited the department of ophthalmology of ningbo medical center from december 2019 to september 2021 were retrospectively collected.All patients were diagnosed as nonorganic active stage before operation, and all of them received endoscopic transethmoidal decompression of the medial orbital wall combined with intramuscular orbital fat decompression due to decreased vision, visual field defect or color vision disorder, and concomitant proptosis.Regular follow-up after operation.The curative effect is judged according to the degree of improvement of visual acuity, color vision, degree of correction of exophthalmos, diplopia, and other complications at 9 months after operation.Orbital ct combined with computer aided measurement software (mimics 21) was used to measure the changes of orbital volume before and after exophthalmos surgery.The relationship between the value and eyeball regression is analyzed.Results.Preoperative exophthalmos ranged from 17.4 mm to 27.6 mm, with an average of ( 22.08 ± 2.86 ) mm.The postoperative exophthalmos was 14-25 mm, with an average of ( 19.52 ± 3.10 ) mm.Among them, 7 eyes (23.3%) had exophthalmos regression less than 1 mm, 6 eyes (20%) had a regression of 1-2 mm, 7 eyes (23.3%) had a regression of 2-3 mm, 5 eyes (16.7%) had a regression of 3-4 mm, and 5 eyes (16.7%) had a regression of 4-5.3 mm.The exophthalmos after operation was significantly lower than that before operation, and the difference was statistically significant ( t = 9.909 , p &lt; 0.05 ).The preoperative orbital volume was 18.6 cm3-25.3 cm3 with an average of ( 22.39 ± 1.91 ) cm3.The postoperative orbital volume was 19.8 cm3-26.6 cm3, with an average of ( 23.89 ± 1.90 ) cm3.the orbital volume change range is 0.1 cm3-3.8 cm3, and the average orbital volume change is ( 1.51 ± 1.00 ) cm3.Compared with preoperative orbital volume, the difference was statistically significant ( t = − 8.074 , p &lt; 0.05 ).Conclusion.Endoscopic decompression of the medial orbital wall through the ethmoid approach combined with decompression of the orbital fat within the muscle cone can effectively correct the exophthalmos while decompressing the orbital apex, and it is minimally invasive and has no facial scars.It has the advantages of extremely low incidence of postoperative diplopia and eye shift.There is a significant correlation between orbital volume changes and the regression of exophthalmos, which can provide reference for clinical guidance of surgical methods and prediction of surgical results.

Journal: Scanning (2022)
Publication types: Research Article;