syedzayyan/paper_mill_benchmark huggingface dataset:
Application of DMAIC Cycle and Modeling as Tools for Health Technology Assessment in a University Hospital.

The health technology assessment (hta) is used to evaluate health services, manage healthcare processes more efficiently, and compare medical technologies.The aim of this paper is to carry out an hta study that compares two pharmacological therapies and provides the clinicians with two models to predict the length of hospital stay (los) of patients undergoing oral cavity cancer surgery on the bone tissue.Methods the six sigma method was used as a tool of hta; it is a technique of quality management and process improvement that combines the use of statistics with a five-step procedure: "define, measure, analyze, improve, control" referred to in the acronym dmaic.Subsequently, multiple linear regression has been used to create two models.Two groups of patients were analyzed: 45 were treated with ceftriaxone while 48 were treated with the combination of cefazolin and clindamycin.Results a reduction of the overall mean los of patients undergoing oral cavity cancer surgery on bone was observed of 40.9% in the group treated with ceftriaxone.Its reduction was observed in all the variables of the ceftriaxone group.The best results are obtained in younger patients (-54.1%) and in patients with low oral hygiene (-52.4%) treated.The regression results showed that the best los predictors for cefazolin/clindamycin are asa score and flap while for ceftriaxone, in addition to these two, oral hygiene and lymphadenectomy are the best predictors.In addition, the adjusted rsquared showed that the variables considered explain most of the variance of los.Conclusion ss methodology, used as an hta tool, allowed us to understand the performance of the antibiotics and provided variables that mostly influence postoperative los.The obtained models can improve the outcome of patients, reducing the postoperative los and the relative costs, consequently increasing patient safety, and improving the quality of care provided.

Journal: Journal of healthcare engineering (2021)
Publication types: Journal Article
Kallikrein proteoforms and reproductive parameters in stallion are conditioned by climate.

Horses are seasonal polyoestrous animals, and the photoperiod is the main factor modulating their reproductive activity.There is no consensus on the andrological and biochemical factors that influence breeding seasonality.To assess the involvement of climate in reproduction, mangalarga marchador stallions were monitored over 1 year regarding semen quality and seminal plasma proteome.Here, we show that kallikrein (klks) proteoforms in seminal plasma are involved in climate conditioning of reproduction.During the breeding season, greater abundance and different types of klks occurred simultaneously to lower sperm motility, greater semen volumes and higher concentrations of glucose and cholesterol.Considering that vasodilation due to activation of the kallikrein-kinin system and the consequent inhibition of the renin-angiotensin system may be associated with lower sperm motility, unravelling the involvement of klk proteoforms in reproductive seasonality is a priority in horse breeding.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Evaluation of breast cosmetic changes with a computer-software; the breast cancer conservative treatment cosmetic results (BCCT. core) in hypofractionated whole breast irradiation after breast-conserving surgery-supplementary analysis of multicenter single-arm confirmatory trial: JCOG0906.

A good cosmetic outcome has been defined as an important endpoint in breast-conserving therapy (bct).Various evaluation methods have been studied, but the optimal method has yet to be identified.The present supplementary analysis of jcog0906 focused on comparing evaluation methods for breast cosmetic outcomes following hypofractionated whole breast irradiation (hfwbi) to examine whether a computer-software (the breast cancer conservative treatment cosmetic results [bcct.Core])-based program evaluation (ce) can be used for asian women in clinical trials of bct.Methods of 306 women, 292 underwent institutional evaluation (ie) for breast cosmetic outcomes before (pre) and 3 years after (post) hfwbi using a 4-point scale (excellent/good/fair/poor), and they were evaluated by ce and a central panel evaluation (pe) on the same scale using 292 pairs of pre/post-hfwbi photographs.Pe was performed twice by consensus of the same two experts with a 3-year interval.Ce was assessed individually by two radiation oncologists, an expert and a non-expert.Intra-observer variability and inter-observer variability were calculated using the kappa (k) and weighted kappa (wk) statistics.Results the agreement between the first and second pe using pre/post-hfwbi photographs was moderate (k = 0.60, wk = 0.64.K = 0.53, wk = 0.60).The agreement between the expert and non-expert on ce was substantial (k = 0.72, wk = 0.76.K = 0.72, wk = 0.77).The inter-observer variability of ce was smaller than the intra-observer variability of pe.Conclusion ce with bcct.Core was considered a reproducible and an appropriate evaluation method for asian women in clinical trials of bct, when breast cosmetic changes were compared between pre/post therapy.

Journal: Breast cancer (Tokyo, Japan) (2022)
Publication types: Multicenter Study;Journal Article
Nursing personality and features in children with autism spectrum disorder aged 0-2: an exploratory case-control study.

Although studies have investigated relationships between autism spectrum disorder (asd) and breastfeeding duration, information concerning these children's nursing styles is limited.This study investigated nursing personality and features and asd.Method one hundred forty-one children aged 24-72 months diagnosed with asd and 128 healthy children were included.Information concerning the family's sociodemographic characteristics and the child's developmental stages was obtained through forms prepared by the authors and from hospital records.The childhood autism rating scale (cars) was used to determine symptom severity in asd.Development levels of children with asd were determined using the denver developmental screening test 2nd edition (ddst ii).Results mothers of children with asd reported higher rates of unintended pregnancies (p = 0.029) [2.380*(1.093-5.182)].Children with asd exhibited less nursing strike (ns) behavior (p= 0.042) [0.388(0.156-0.967)] and less eye contact during breastfeeding (ecdb) (p= 0.009) [2.300(1.236-4.282)].Ns reduced the risk of asd 2.6-fold, while absence of ecdb increased the risk 2.3-fold, and unintended pregnancy increased the risk 2.4-fold.Higher cars scores were determined in children with asd with vaginal delivery histories (p= 0.041) and histories of incubation (p= 0.025).Lack of ecdb was associated with decreased social and gross motor scores at ddst-ii (p= 0.005).Conclusion babies with asd began breastfeeding at least as early as typically developing peers and for similar lengths of time.However, babies with asd exhibited less ns behavior and less eye contact during breastfeeding.Babies with asd perceive no emotional cues even in the first months, and may therefore not exhibit ns behavior.

Journal: Nutritional neuroscience (2022)
Publication types: Journal Article
A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication.

The process of domestication has led to dramatic differences in behavioral traits between domestic dogs and gray wolves.Whole-genome research found that a class of putative positively selected genes were related to various aspects of learning and memory, such as long-term potentiation and long-term depression.In this study, we constructed a single-nucleus transcriptomic atlas of the dog hippocampus to illustrate its cell types, cell lineage and molecular features.Using the transcriptomes of 105 057 nuclei from the hippocampus of a beagle dog, we identified 26 cell clusters and a putative trajectory of oligodendrocyte development.Comparative analysis revealed a significant convergence between dog differentially expressed genes (degs) and putative positively selected genes (psgs).Forty putative psgs were degs in glutamatergic neurons, especially in cluster 14, which is related to the regulation of nervous system development.In summary, this study provides a blueprint to understand the cellular mechanism of dog domestication.

Journal: National science review (2022)
Publication types: Journal Article
Improved long-chain omega-3 polyunsaturated fatty acids in sago palm weevil (Rhynchophorus ferrugineus) larvae by dietary fish oil supplementation.

The nutritional values of sago palm weevil larvae (spwl) reared on mixed plant-based diets (ground sago palm trunk (gs), cornmeal, rice bran, soybean, and perilla seed), containing different levels of dietary fish oil (fo) were compared to those reared on commercial pig feed (pf) and gs.Increased fo content resulted in an increase in ω-3 fatty acids (fa) in spwl (p < 0.05), especially α-linolenic acid and eicosapentaenoic acid.When fed fo-fortified diets instead of pf, the health-promoting indices of the spwl lipid improved significantly (e.g., decreased ω-6/ω-3 ratio, thrombogenicity index, and hypercholesterolemic fa with increased pufa content).The lipid, protein, and mineral contents of spwl were increased while growth performance was maintained on a 1.5% fo-fortified diet.Higher fo levels (3-5%) had a negative impact on the nutritional values and growth performance of the spwl.Thus, there was a reasonable chance of developing a high-nutrient alternative insect for human consumption.

Journal: Food chemistry (2022)
Publication types: Journal Article
Friedelin Attenuates Neuronal Dysfunction and Memory Impairment by Inhibition of the Activated JNK/NF-κB Signalling Pathway in Scopolamine-Induced Mice Model of Neurodegeneration.

Oxidative stress (os) and c-jun n-terminal kinase (jnk) are both key indicators implicated in neuro-inflammatory signalling pathways and their respective neurodegenerative diseases.Drugs targeting these factors can be considered as suitable candidates for treatment of neuronal dysfunction and memory impairment.The present study encompasses beneficial effects of a naturally occurring triterpenoid, friedelin, against scopolamine-induced oxidative stress and neurodegenerative pathologies in mice models.The treated animals were subjected to behavioural tests i.e., y-maze and morris water maze (mwm) for memory dysfunction.The underlying mechanism was determined via western blotting, antioxidant enzymes and lipid profile analyses.Molecular docking studies were carried out to predict the binding modes of friedelin in the binding pocket of p-jnk protein.The results reveal that scopolamine caused oxidative stress by (1) inhibiting catalase (cat), peroxidase enzyme (pod), superoxide dismutase (sod), and reduced glutathione enzyme (gsh); (2) the up-regulation of thiobarbituric acid reactive substances (tbars) in mice brain; and (3) affecting the neuronal synapse (both pre- and post-synapse) followed by associated memory dysfunction.In contrast, friedelin administration not only abolished scopolamine-induced oxidative stress, glial cell activation, and neuro-inflammation but also inhibited p-jnk and nf-κb and their downstream signaling molecules.Moreover, friedelin administration improved neuronal synapse and reversed scopolamine-induced memory impairment accompanied by the inhibition of β-secretase enzyme (bace-1) to halt amyloidogenic pathways of amyloid-β production.In summary, all of the results show that friedelin is a potent naturally isolated neuro-therapeutic agent to reverse scopolamine-induced neuropathology, which is characteristic of alzheimer's disease.

Journal: Molecules (Basel, Switzerland) (2022)
Publication types: Journal Article
Magnesium: An old player revisited in the context of CKD-MBD.

Chronic kidney disease (ckd) is associated with a wide number of abnormalities in mineral metabolism.Often, these alterations are the leading players in the development of comorbidities associated with ckd, which are risk factors of mortality.In this context, mineral and bone disorder associated with ckd (ckd-mbd) are highlighted, connecting bone, renal, and cardiovascular disorders.Many studies have been led to propose strategies to avoid, reduce, or slow down ckd-mbd progression using different compositions of metallic elements-based p binders such as aluminum, magnesium, or calcium.Magnesium, the aim of this review, has been used by nephrologists to treat ckd-mbd with a variable acceptation due mainly to different results on bone homeostasis.Nowadays, we have new evidence about the efficacy of magnesium supplementation on vascular calcification, renal function, and bone disorders, suggesting potential beneficial effects of magnesium in the management of ckd-mbd.

Journal: Clinica chimica acta; international journal of clinical chemistry (2020)
Publication types: Journal Article;Review
Tracker-Based Personal Advice to Support the Baby's Healthy Development in a Novel Parenting App: Data-Driven Innovation.

The current generation of millennial parents prefers digital communications and makes use of apps on a daily basis to find information about child-rearing topics.Given this, an increasing amount of parenting apps have become available.These apps also allow parents to track their baby's development with increasing completeness and precision.The large amounts of data collected in this process provide ample opportunity for data-driven innovation (ddi).Subsequently, apps are increasingly personalized by offering information that is based on the data tracked in the app.In line with this, philips avent has developed the u grow app, a medical-grade app dedicated to new parents for tracking their baby's development.Through so-called insights, the u grow app seeks to provide a data-driven solution by offering parents personal advice that is sourced from user-tracked behavioral and contextual data.Objective the aim of this study was twofold.First, it aimed to give a description of the development process of the insights for the u grow app.Second, it aimed to present results from a study about parents' experiences with the insights.Methods the development process comprised 3 phases: a formative phase, development phase, and summative phase.In the formative phase, 3 substudies were executed in series to understand and identify parents' and health care professionals' (hcps) needs for insights, using qualitative and quantitative methods.After the formative phase, insights were created during the development phase.Subsequently, in the summative phase, these insights were validated against parents' experience using a quantitative approach.Results as part of the formative phase, parents indicated having a need for smart information based on a data analysis of the data they track in an app.Hcps supported the general concept of insights for the u grow app, although specific types of insights were considered irrelevant or even risky.After implementing a preliminary set of insights in a prototype version of the u grow app and testing it with parents, the majority of parents (87%) reported being satisfied with the insights.From these outcomes, a total of 89 insights were implemented in a final version of the u grow app.In the summative phase, the majority of parents reported experiencing these insights as reassuring and useful (94%), as adding enjoyment (85%), and as motivating for continuing tracking for a longer period of time (77%).Conclusions parents experienced the insights in the u grow app as useful and reassuring and as adding enjoyment to their use of the u grow app and tracking their baby's development.The insights development process we followed showed how the quality of insights can be guaranteed by ensuring that insights are relevant, appropriate, and evidence based.In this way, insights are an example of meaningful ddi.

Journal: JMIR mHealth and uHealth (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
A Case OfEntamoeba HistolyticaInfection Among Men Who Have Sex With Men.

Entamoeba histolyticais a parasite responsible for intestinal amebiasis and possible extraintestinal manifestations, such as liver abscesses.India, africa, mexico, and central and south america have some of the highest rates of infection due to poor socioeconomic and environmental conditions.The infection has become more common in the united states due to an increase in emigration.There has been a rising incidence of sexual transmission of the infection, most commonly seen in men who have sex with men.Here, we present a case of a symptomatic extraintestinal e histolyticainfection in a young hispanic bisexual man.

Journal: Journal of investigative medicine high impact case reports (2022)
Publication types: Case Reports;Journal Article
The value of repeat kidney biopsy during an atypical course of membranous nephropathy.

The clinical trajectory for patients with primary membranous nephropathy ranges widely from spontaneous remission to a rapid decline in kidney function.Etiologies for rapid progression with membranous nephropathy include concurrent bilateral renal vein thrombosis, malignant hypertension, and crescentic membranous nephropathy.Given the wide heterogeneity in prognosis, timing of immunosuppressive therapy is often challenging and centers around an individual patient's perceived risk for rapidly progressive disease.Case presentation herein, we describe the clinical course of a young patient who initially developed a typical presentation of membranous nephropathy with consistent kidney biopsy findings.Given clinical stability, a six month observation period was undertaken prior to initiating immunosuppression.Within this observation window, the patient developed community acquired pneumonia followed several weeks later by a sudden, rapid decline in kidney function requiring dialysis.Repeat kidney biopsy revealed post-infectious glomerulonephritis superimposed upon a background of membranous nephropathy.Immunosuppressive therapy resulted in a favorable long-term outcome with normalization of kidney function and remission of nephrotic syndrome.To our knowledge, this is the first report of the simultaneous occurrence of these two glomerular disease processes.Conclusion this case illustrates the value of repeat kidney biopsy during an atypical course of membranous nephropathy.Superimposed glomerular disease processes should be considered during a course of rapidly progressive membranous nephropathy.

Journal: BMC nephrology (2022)
Publication types: Case Reports;Journal Article
Association of insulin-like growth factor binding protein-7 promoter methylation with esophageal cancer in peripheral blood.

The insulin-like growth factor (igf) signaling pathway has an important role in many cancers, including esophageal cancer (ec).Igf-binding protein 7 (igfbp7) is one of the proteins in this signaling pathway, and its role in cancer has not yet been fully clarified.In the present study, we evaluated the clinical relevance of igfbp7 methylation status and m rna expression in ec patients compared to healthy controls.We also investigated whether igfbp7 methylation status affects m rna expression.Methods the study comprised 100 ec patients and 105 healthy controls.Methylation specific pcr (msp) was used to examine igfbp7's promoter methylation and real-time quantitative reverse transcription pcr (q rt-pcr) was used to assess igfbp7 m rna expression.Results the igfbp7 promoter methylation was significantly higher in controls than in ec patients (p 0.05).Conclusion our study indicated that promoter unmethylation and m rna expression of the igfbp7 promoter in peripheral blood could be different biomarkers for ec.Furthermore, unmethylation of the igfbp7 promoter in ec patients was associated with reflux and elevated globulin levels.More studies with a larger number of cases is needed to confirm this association.

Journal: Molecular biology reports (2022)
Publication types: Journal Article
Site dependent catalytic water dissociation on an anisotropic buckled black phosphorus surface.

Black phosphorus (bp) is unique among 2d materials due to its anisotropic puckered structure.It has been used as a multifunctional catalyst for various purposes.In this study, we performed first principles molecular dynamics simulations to understand the water-splitting reaction on a bi-layer bp surface.We focused on the site-specific aqueous reactivity of the buckled surface.A difference in the axis-dependent reactivity is observed owing to edge defects and exposed sites.Thus, we believe that bp edges, which significantly affect the interfacial water or organic solvent molecules, must exhibit very different edge-dependent reactivity.Experiments suggested the increasing catalytic efficiency of undisturbed bp in the order bulk, few-layered bp, and bp quantum dots.We choose three active sites to investigate the mechanistic details of the oer: the zigzag (zz), armchair (ac), and bulk sites.This study will provide insight into the enhanced catalytic activity when more edges are exposed as the active surface.We hope to clarify the reactive pathway in an aqueous solution supported by bi-layer bp by exploring the two different mechanisms for forming the ooh* complex.We explore and report two mechanisms: a simple push-pull reaction for oxygen-oxygen bond formation, the nucleophilic attack by formed oh-and an attack by a water molecule.The free energy barriers procured for mechanism 1 taking place at the zigzag, armchair, and bulk sites are 7.59 ± 0.33, 9.04 ± 0.01, and 12.80 ± 0.09 kcal mol-1, respectively.For mechanism 2 the free energy barriers are 7.62 ± 0.11, 9.15 ± 0.16, and 11.63 ± 0.11 kcal mol-1for the zz, ac, and bulk sites.The interlink between both the mechanisms is established concerning the reported free energy barriers for ooh* formation.The zz site is found to lower the activation barrier for the rate-determining step, followed by the ac and bulk.

Journal: Physical chemistry chemical physics : PCCP (2022)
Publication types: Journal Article