syedzayyan/paper_mill_benchmark huggingface dataset:
A meta-analysis of hormone administration effects on cooperative behaviours: Oxytocin, vasopressin, and testosterone.

The hormones oxytocin, vasopressin, and testosterone have been implicated in cooperative behaviours and have attracted increasing research interest for their potential to regulate human cooperation in both healthy and clinical populations.However, the behavioural effects of the administration of these hormones remain to be verified.The current analysis included 41 studies involving 3,269 participants with a narrow age range.We examined the administration effects of these hormones on cooperative behaviour and the regulatory effects of individual characteristics, hormone interventions, and task structure and context.Results revealed a moderate positive effect size of oxytocin intranasal administration, a large negative effect size of vasopressin intranasal administration, and nonsignificant effects of testosterone administration on cooperative behaviours.Participants with mental dysfunctions were less sensitive to oxytocin and vasopressin administration.Oxytocin administration was effective in an in-group situation and for initial choices, corroborating a tit-for-tat strategy.

Journal: Neuroscience and biobehavioral reviews (2021)
Publication types: Journal Article;Meta-Analysis;Research Support, Non-U.S. Gov't;Review
Beyond the smart city: a typology of platform urbanism.

Platform urbanism has emerged in recent years as an area of research into the ways in which digital platforms are increasingly central to the governance, economy, experience, and understanding of the city.In the paper, we argue that platform urbanism is an evolution of the smart city, constituted by novel, digitally-enabled socio-technical assemblages that enable new forms of social, economic and political intermediation.We offer a typological framework for a better conceptualization of platform urbanism and its complex socio-economic relationships.We further outline several directions for future research on platform urbanism, specifically: a.) the need to critically investigate new power geometries of corporate, legal and regulatory alignments; b.) how platform urbanism may be expressed in, and affect, cities in the global south; c.) how it may need to be critically engaged with in regard to its development in response to emergent events such as the covid-19 pandemic; and d.) how it may shape visions of the current and future city.

Journal: Urban transformations (2022)
Publication types: Journal Article
Microwave Absorption Properties of Multi-Walled Carbon Nanotubes/Carbonyl Iron Particles/Polyurethane Foams.

In order to improve the microwave absorption performance of absorbing materials, the composite foam absorbing materials with different multi-walled carbon nanotube (mwcnt) contents were prepared using polyurethane foam as the substrate and mwcnts and flaked carbonyl iron powder as absorbers.The electromagnetic properties of the materials were characterized and analyzed.Then, cst electromagnetic simulation software was used to simulate the electromagnetic shielding effect of absorbing materials on mechatronics products under a strong electromagnetic irradiation environment, and, finally, it was verified by irradiation experiment.The results show that the materials have good microwave absorption properties, in which the composites containing 1.5 wt.% mwcnts exhibit good microwave absorption properties.The minimum reflectivity reaches -29 d b when the thickness is 3 mm and -15.6 d b when the thickness is 1.5 mm, with a bandwidth of 5.7 ghz for reflectivity less than -10 d b.The good microwave absorption performance of the material is due to the synergistic effect of mwcnts particles and good impedance matching.The simulation and experimental results show that the mechatronics product with absorbing materials can protect against strong electromagnetic interference and ensure the normal operation of the mechatronics product circuits.

Journal: Materials (Basel, Switzerland) (2022)
Publication types: Journal Article
Anthocyanin Biosynthesis Associated with Natural Variation in Autumn Leaf Coloration inQuercus alienaAccessions.

Quercus alienais an economically important tree species and one of the dominant native oak species in china.Although its leaves typically turn yellow in autumn, we observed natural variants with red leaves.It is important to understand the mechanisms involved in leaf color variation in this species.Therefore, we compared a q.Alienatree with yellow leaves and three variants with red leaves at different stages of senescence in order to determine the causes of natural variation.We found that the accumulation of anthocyanins such as cyanidin 3-o-glucoside and cyanidin 3-o-sambubiglycoside had a significant effect on leaf coloration.Gene expression analysis showed upregulation of almost all genes encoding enzymes involved in anthocyanin synthesis in the red-leaved variants during the early and main discoloration stages of senescence.These findings are consistent with the accumulation of anthocyanin in red variants.Furthermore, the variants showed significantly higher expression of transcription factors associated with anthocyanin synthesis, such as those encoded by genes qa myb1and qa myb3.Our findings provide new insights into the physiological and molecular mechanisms involved in autumn leaf coloration in q.Aliena, as well as provide genetic resources for further development and cultivation of valuable ornamental variants of this species.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article
Zoonoses and Animal Culling: The Need for One Health Policy.

One health (oh) as a biomedical and social movement calls to reorient public health approaches toward more holistic, nonanthropocentric approaches that do not exclude the interests of animals and ecosystems.Oh thus urges reexamination, from both scientific and moral perspectives, of the practice of culling pet, farm, or wild animals in the face of a zoonosis.Pandemics such as covid and monkeypox highlight the need for more rigorous analysis of the justifications traditionally provided to back these culling practices.Such analyses should then ground reasonable oh policies and legislation that consider the rights of humans, animals, and the environment.Bill s.861, "advancing emergency preparedness through one health act of 2021," which was introduced in the u.s.Congress, is a step in the right direction.

Journal: The Hastings Center report (2022)
Publication types: Journal Article
Development of a Patient-centered Quality Measurement Framework for Measuring, Monitoring, and Optimizing Rheumatoid Arthritis Care in Canada.

The aim of this study was to develop a patient-centered quality measurement framework to address a predefined vision statement and 7 strategic objectives for rheumatoid arthritis (ra) care that was developed in prior qualitative work with arthritis stakeholders.Methods one hundred forty-seven ra-related performance measures (pms) were identified from a systematic review.A candidate list of 26 pms meeting predefined criteria and addressing the strategic objectives previously defined was then assessed during a 3-round (r) modified delphi.Seventeen panelists with expertise in ra, quality measurement, and/or lived experience with ra rated each pm on a 1-9 scale based on the items of importance, feasibility, and priority for inclusion in the framework during r1 and r3, with a moderated discussion in r2.Pms with median scores ≥ 7 on all 3 items without disagreement were included in the final set, which then underwent public comment.Results twenty-one measures were included in the final framework (15 pms from the delphi and 6 published system-level measures on access to care and treatment).The measures included 4 addressing early access to care and timely diagnosis, 12 evidence-based care for ra and related comorbidities, 1 addressing patient participation as an informed partner in care, and 4 on patient outcomes.Conclusion the proposed framework builds upon existing measures capturing early access to care and treatment in ra and adds important pms to promote high-quality ra care and outcome measurement.In the next phase, the authors will test the framework in clinical practice in addition to addressing certain areas where no suitable pms were identified.

Journal: The Journal of rheumatology (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Systematic Review
Preventive Effects of Velvet Antler(Cervus elaphus)against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPK/NF-κB Activation and Inducing AMPK/Nrf2 Pathways.

Velvet antler (cervus elaphus) is a typical traditional animal medicine.It is considered to have various pharmacological effects including stimulation of the immune system, increase in the physical strength, and enhancement of sexual function.This paper aims to investigate the aqueous extract of velvet antler (ava) in the mouse models of lps-induced ali.Inhibition of no, tnf-α, il-1β, il-6, and il-10 productions contributes to the attenuation of lps-induced lung inflammation by ava.A 5-day pretreatment of ava prevented histological alterations and enhanced antioxidant enzyme activity in lung tissues.Ava significantly reduced the material (total number of cells and proteins) in the balf.Western blot analysis revealed that the expression of i nos and cox-2 and phosphorylation of iκb-αand mapks proteins are blocked in lps-stimulated macrophages as well as lps-induced lung injury in mice.Consistent with this concept, the phosphorylation of ca mkkβ, lkb1, ampk, nrf2, and ho-1 was activated after ava treatment.The results from this study indicate ava has anti-inflammatory effects in vivo and ava is a potential model for the development of health food.In addition, its pathways may be at least partially associated with inhibiting mapk/nf-κb activation and upregulating ampk/nrf2 pathways and the regulation of antioxidant enzyme activity.

Journal: Evidence-based complementary and alternative medicine : eCAM (2018)
Publication types: Journal Article
Knowledge creation through collaboration: The role of shared institutional affiliations and physical proximity.

This paper examines how shared affiliations within an institution (e.g., same primary appointment, same secondary appointment, same research center, same laboratory/facility) and physical proximity (e.g., walking distance between collaborator offices) shape knowledge creation through biomedical science collaboration in general, and interdisciplinary collaboration in particular.Using archival and publication data, we examine pairwise research collaborations among 1,138 faculty members over a 12-year period at a medical school in the united states.Modeling at the dyadic level, we find that faculty members with more shared institutional affiliations are positively associated with knowledge creation and knowledge impact, and that this association is moderated by the physical proximity of collaborators.We further find that the positive influence of disciplinary diversity (e.g., collaborators from different fields) on knowledge impact is stronger among pairs that share more affiliations and is significantly reduced as the physical distance among collaborators increases.These results support the idea that shared institutional affiliations and physical proximity can increase interpersonal contact, providing more opportunities to develop trust and mutual understanding, and thus alleviating some of the coordination issues that can arise with higher disciplinary diversity.We discuss the implications for future research on scientific collaborations, managerial practice regarding office space allocation, and strategic planning of initiatives aimed at promoting interdisciplinary collaboration.

Journal: Journal of the Association for Information Science and Technology (2021)
Publication types: Journal Article
Three-Year Results of a Prospective Statewide Insurance Coverage Pilot for Proton Therapy: Stakeholder Collaboration Improves Patient Access to Care.

Proton therapy is increasingly prescribed, given its potential to improve outcomes; however, prior authorization remains a barrier to access and is associated with frequent denials and treatment delays.We sought to determine whether appropriate access to proton therapy could ensure timely care without overuse or increased costs.Methods our large academic cancer center collaborated with a statewide self-funded employer (n = 186,000 enrollees) on an insurance coverage pilot, incorporating a value-based analysis and ensuring preauthorization for appropriate indications.Coverage was ensured for prospective trials and five evidence-supported anatomic sites.Enrollment initiated in 2016 and continued for 3 years.Primary end points were use, authorization time, and cost of care, with case-matched comparison of total charges at 1 month pretreatment through 6 months posttreatment.Results thirty-two patients were approved over 3 years, with only 22 actually receiving proton therapy, versus a predicted use by 120 patients (p 6 months of follow-up were case matched by treatment site to 17 patients receiving proton therapy, with no significant differences in sex, age, performance status, stage, histology, indication, prescribed fractions, or chemotherapy.Total medical costs (including radiation therapy [rt] and non-rt charges) for patients treated with pbt were lower than expected (a cost increase initially was expected), with no significant difference in total average charges (p= .82), in the context of overall ancillary care use.Conclusion this coverage pilot demonstrated that appropriate access to proton therapy does not necessitate overuse or significantly increase comprehensive medical costs.Objective evidence-based coverage polices ensure appropriate patient selection.Stakeholder collaboration can streamline patient access while reducing administrative burden.

Journal: JCO oncology practice (2020)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Are suicide attempters more impulsive than suicide ideators?

For over 100 years impulsiveness has been cited as a key factor in why some people that think about killing themselves go on to attempt suicide.Yet prior studies are limited by not using experimental groups that can test this hypothesis and by treating impulsiveness as a unidimensional construct.To overcome these limitations, we compared suicide ideators and suicide attempters on several dimensions of impulsiveness.Method in study 1 we compared inpatient suicide attempters who made an attempt within the prior two weeks (n = 30), current inpatient suicide ideators (n = 31), and community controls (n = 34) on several dimensions of impulsiveness using self-report and behavioral measures.In study 2 (n = 346), we compared three similar groups based on lifetime and past year suicidal behaviors on several of the measures in study 1.Results in study 1, we found only that negative urgency was clearly elevated among attempters compared with ideators.In study 2, there were no significant differences on any impulsiveness constructs, including negative urgency.Conclusions results from the two studies suggest that attempters may not have significantly elevated trait impulsiveness, compared to ideators; however, attempters may have higher impulsiveness when in a negative state.

Journal: General hospital psychiatry (2020)
Publication types: Comparative Study;Journal Article;Research Support, Non-U.S. Gov't
AIM2 inflammasome activation may mediate high mobility group box 1 release in murine allergic rhinitis.

Introduction high mobility group box 1 protein participates in the pathogenesis of allergic rhinitis.Activation of the inflammasome can mediate the release of high mobility group box 1.The role of the absent in melanoma 2 inflammasome in allergic rhinitis remains unclear.Objective this study aimed to investigate the function of absent in melanoma 2 inflammasome in murine allergic rhinitis and the interaction between high mobility group box 1 and the absent in melanoma 2 inflammasome.Methods a murine allergic rhinitis model was established using twenty balb/c mice.Expression of the components of the absent in melanoma 2 inflammasome: absent in melanoma 2, apoptosis-associated speck-like protein containing a card (asc), caspase-1 p20, and additional nod-like receptor family pyrin domain containing 3 (nlrp3) were detected by western blotting during allergic rhinitis.Alterations of absent in melanoma 2, caspase-1, and high mobility group box 1 after ovalbumin challenge were demonstrated by immunohistochemistry.Td t-mediated d utp nick end labeling, tunel assay, and cleavage of caspase-3 and parp-1 were used for the observation of pyroptosis.Results eosinophilia and goblet cell infiltration were observed in the nasal mucosa of mice in the allergic rhinitis group.Absent in melanoma 2, asc, and caspase-1 p20 increased after ovalbumin exposure while nlrp3 did not.High mobility group box 1 was released in the nasal mucosa of allergic rhinitis mice.Tunel-positive cells increased in the epithelium and laminae propria, whereas cleavage of caspase-3 and parp-1 was not observed.Conclusions the absent in melanoma 2 inflammasome was activated and pyroptosis may occur in the nasal mucosa after ovalbumin treatment.These may contribute to the translocation of high mobility group box 1 and the development of allergic rhinitis.

Journal: Brazilian journal of otorhinolaryngology (2022)
Publication types: Journal Article
Diagnostic value of serum versus plasma phospho-tau for Alzheimer's disease.

Blood phosphorylated tau (p-tau) forms are promising alzheimer's disease (ad) biomarkers, but validation in matrices other than ethylenediaminetetraacetic acid (edta) plasma is limited.Firstly, we assessed the diagnostic potential of p-tau231 and p-tau181 in paired plasma and serum samples.Secondly, we compared serum and cerebrospinal fluid (csf) samples from biomarker-positive ad and biomarker-negative control participants.Methods we studied three independent cohorts (n=115 total): cohorts 1 and 2 included individuals with paired plasma and serum, while cohort 3 included paired serum and csf.Blood-based p-tau231 and p-tau181 were measured using in-house or commercial single molecule array (simoa) methods.Results serum and plasma p-tau231 and p-tau181 were two- to three-fold increased in biomarker-positive ad versus biomarker-negative controls (p≤0.0008).Serum p-tau231 separated diagnostic groups with area under the curve (auc) of 82.2% (cohort 3) to 88.2% (cohort 1) compared with 90.2% (cohort 1) for plasma.Similarly, p-tau181 showed auc of 89.6% (cohort 1) to 89.8% (cohort 3) in serum versus 85.4% in plasma (cohort 1).P-tau231 and p-tau181 correlated slightly better in serum (rho=0.92 for cohort 1, 0.93 for cohort 3) than in plasma (rho=0.88, cohort 1).Within-individual p-tau181 (quanterix) and p-tau231 concentrations were twice higher in plasma versus serum, but p-tau181 (in-house, gothenburg) levels were not statistically different.Bland-altman plots revealed that the relative difference between serum/plasma was larger in the lower range.P-tau levels in paired plasma and serum correlated strongly with each other (rho=0.75-0.93) as well as with csf aβ42(rho= -0.56 to -0.59), p-tau and total-tau (rho=0.53-0.73).Based on the results, it seems possible that serum p-tau reflects the same pool of brain-secreted p-tau as in csf; we estimated that less than 2% of csf p-tau is found in serum, being same for both controls and ad.Conclusions comparable diagnostic performances and strong correlations between serum versus plasma pairs suggest that p-tau analyses can be expanded to research cohorts and hospital systems that prefer serum to other blood matrices.However, absolute biomarker concentrations may not be interchangeable, indicating that plasma and serum samples should be used independently.These results should be validated in independent cohorts.

Journal: Alzheimer's research & therapy (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Hemodynamic Effects of Sacubitril/Valsartan in Patients with Reduced Left Ventricular Ejection Fraction Over 24 Months: A Retrospective Study.

The effects of sacubitril/valsartan in patients with chronic heart failure with reduced ejection fraction (hfr ef) were recently reported.However, the hemodynamic impact of this well-established treatment in patients with hfr ef has been poorly systematically researched.Aim we aimed to investigate the hemodynamic effects of sacubitril/valsartan among patients with hfr ef.Methods between 2016 and 2020, we retrospectively collected data for patients with hfr ef treated at the university medical center mannheim, germany.Data for 240 patients with hfr ef were available.We systematically analyzed echocardiographic parameters, all-cause hospitalization, and congestion rate.Results the left ventricular ejection fraction (lvef) improved from a median (minimum; maximum) of 28% (3; 65) before initiation of sacubitril/valsartan to a median of 34% (13; 64) at 24-month follow-up (p < 0.001).Systolic pulmonary atrial pressure (papsys) decreased from a median of 30 mm hg (13; 115) to 25 mm hg (20; 80) at 24-month follow-up (p = 0.005).The median (minimum; maximum) tricuspid annular plane systolic excursion improved from 17 mm (3; 31) at baseline to 20 mm (9; 30) at 12-month follow-up (p = 0.007).The incidence of severe and moderate mitral, tricuspid, and aortic valvular insufficiency improved after treatment.Hospitalization and congestion rates reduced at 24-month follow-up.The mortality rate in echocardiographic and functional nonresponders was higher than in responders (12.1 vs.5.2%; p = 0.1 and 11.3 vs.3.1%; p = 0.01, respectively).Conclusion follow-up 24 months after starting treatment with sacubitril/valsartan revealed sustained improvements in echocardiographic parameters, including lvef, papsys, and cardiac valvular insufficiency.Rates of all-cause hospitalization and congestion had decreased significantly at follow-up.The mortality rate was higher in echocardiographic and functional nonresponders.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions (2022)
Publication types: Journal Article