syedzayyan/paper_mill_benchmark huggingface dataset:
MicroRNA-140-5p elevates cerebral protection of dexmedetomidine against hypoxic–ischaemic brain damage via the Wnt/β-catenin signalling pathway

Hypoxia–ischaemia ( hi ) remains a major cause of foetal brain damage presented a scarcity of effective therapeutic approaches.Dexmedetomidine ( dex ) and micro rna ‐140‐5p (mi r‐140‐5p) have been highlighted due to its potentially significant role in the treatment of cerebral ischaemia.This study was to investigate the role by which mi r‐140‐5p provides cerebral protection using dex to treat hypoxic–ischaemic brain damage ( hibd ) in neonatal rats via the wnt/β‐catenin signalling pathway.The hibd rat models were established and allocated into various groups with different treatment plans, and eight sd rats into sham group.The learning and memory ability of the rats was assessed.Apoptosis and pathological changes in the hippocampus ca 1 region and expressions of the related genes of the wnt/β‐catenin signalling pathway as well as the genes responsible of apoptosis were detected.Compared with the sham group, the parameters of weight, length growth, weight ratio between hemispheres, the rate of reaching standard, as well as bcl‐2 expressions, were all increased.Furthermore, observations of increased levels of cerebral infarction volume, total mortality rate, response times, total response duration, expressions of wnt1, β‐catenin, tcf ‐4, e‐cadherin, apoptosis rate of neurons, and bax expression were elevated.Following dex treatment, the symptoms exhibited by hibd rats were ameliorated.Mi r‐140‐5p and si‐wnt1 were noted to attenuate the progression of hibd .Our study demonstrates that mi r‐140‐5p promotes the cerebral protective effects of dex against hibd in neonatal rats by targeting the wnt1 gene through via the negative regulation of the wnt/β‐catenin signalling pathway.

Journal: Journal of Cellular and Molecular Medicine (JCMM) (2018)
Publication types: Research Article;
LncMAPK6 drives MAPK6 expressionand liver TIC self-renewal

Background liver tumor initiating cells (tics) have self-renewal and differentiate capacities, and largely contribute to tumor initiation, metastasis and drug resistance.Mapk signaling is a critical pathway in many biological processes, while its role in liver tics hasn’t been explored.Methods online-available dataset was used for unbiased screening.Liver tics were examined cd133 facs or oncosphere formation.Tic self-renewal was detected by oncosphere formation and tumor initiation assay.Lnc rna function was detected by loss of function or gain of function assays.The molecular mechanism of lnc rna was explored by rna pulldown, rna immunoprecipitation, ch ip, western blot and double fish.Results here, we examined the expression profiles of mapk components (mapks, map2ks, map3ks, map4ks), and found mapk6 is most highly expressed in liver cancer samples.Moreover, a divergent lnc rna (long noncoding rna) of mapk6, termed lnc mapk6 here, is also overexpressed along with liver tumorigenesis.Lnc mapk6 promotes liver tumor propagation and tic self-renewal through mapk6.Lnc mapk6 interacts with and recruits rna polymerase ii to mapk6 promoter, and finally activates the transcription of mapk6.Through mapk6 transcriptional regulation, lnc mapk6 drives mark signaling activation.Lnc mapk6 -mapk6 pathway can be used for liver tic targeting.Altogether, lnc mapk6 promotes mark signaling and the self-renewal of liver tics through mapk6 expression.Conclusion mapk6 was the most highly expressed mapk component in liver cancer and liver tics and lnc mapk6 participated in the transcriptional regulation of mapk6in cis.This work revealed the importance role of mapk signaling in liver tic self-renewal and added a new layer for liver tic and mapk6 expression regulation.

Journal: Journal of Experimental & Clinical Cancer Research: (CR) (2018)
Publication types: Research Article;
Construction of e-commerce platform for agricultural tourism products under the background of big data

In recent years, the rapid development of information technology, such as the internet of things, cloud computing and mobile internet, has driven the production, circulation and consumption of agricultural tourism products in china to become intelligent.Through innovation, building agricultural tourism e-commerce platform, can realize the upstream agricultural tourism resources with end consumers of rapid convergence, and just in time to build a true and complete database, the agricultural tourism industrial structure adjustment and upgrade play a great role.Based on the background of big data, the author in the agricultural tourism products based on the analysis of the electronic commerce development present situation, combining with the characteristics of the era of experience economy tourism consumption and puts forward the innovative development of china’s agricultural tourism products e-commerce platform strategy.

Journal: Journal of Physics: Conference Series (2019)
Publication types: Conference Abstract/Paper;
Parametric Design of Quasi-Natural Waterscape Gardens Based on Big Data Technology

In order to better design the water scenes of garden, the natural water scenes of garden parameters are designed by combining the big data technology, the water scenes of garden generation rules are collected by the pseudo-natural principle, and the garden landscape parameters are designed by combining the regular production characteristics with the big data technology.In order to ensure the rationality of the principle landscape design, the pseudo-natural water scenes of garden parameters are standardized, and the standard parameters are input into the grasshopper auxiliary simulation software, so that the optimal design scheme of the pseudo-natural dynamic correlation water scenes of garden view is automatically generated.Finally, through experiments, it is proved that the landscape simulation effect of pseudo-natural water scenes of garden parametric design based on big data technology is more satisfactory than that of traditional design simulation results.

Journal: Journal of Physics: Conference Series (2019)
Publication types: Conference Abstract/Paper;
Research on Transmission Functions of Foreign Language and Chinese Medicine Culture under the Background of “Big Data”

In order to solve the problem of learning resource description in big data environment, this paper proposes a learning resource description system based on metamodel, that is, to establish a set of metadata model that is not only in line with the standards of learning resource description, but also has extensibility.By referring or mapping to the element set of the common metamodel, the elements of the metadata model of various resources are obtained to achieve the compatibility between different metadata models.This paper combines the learning resource model in the context of big data, and analyses the transmission functions of foreign language and chinese medicine culture, including communication of language, communication of chinese medicine culture, communication of chinese medicine trade and communication of chinese medicine financing.

Journal: Journal of Physics: Conference Series (2019)
Publication types: Conference Abstract/Paper;
Traditional Chinese medicine orthopedic rehabilitation treatment for senile osteoarthritis based on the Big Data

Objective: to study and analyze the effect of traditional chinese medicine orthopedic rehabilitation therapy on senile osteoarthritis from the analysis of big data.Methods: seventy elderly patients with osteoarthritis admitted to our hospital from march 2015 to march 2017 were enrolled.The grouping method is a random number table method, which is divided into an experimental group and a reference group, each of which is 35 cases.The patients in the reference group were treated with nimesulide orally, and the patients in the experimental group were treated with traditional chinese medicine orthopedics.The clinical effects of the two groups were compared.Results: the effective rate of treatment in the experimental group (97.14%) was significantly higher than that in the reference group (82.86%).The difference between the two groups was statistically significant (p&lt;0.05).There were significant differences in vas scores and joa scores between groups, and p &lt; 0.05.Conclusion: the treatment of senile osteoarthritis patients with traditional chinese medicine orthopedics has achieved remarkable results.The quality of life of patients has been significantly improved, the treatment efficiency has been improved, and the pain of patients has been alleviated.It is worthy of clinical reference and further popularization.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
The Development Space of University Art Design Education in the Era of Big Data

After the arrival of the era of big data, colleges and universities of art design are also facing new challenges and opportunities.How to stand out in the fierce competition has become an important issue facing art design education.The purpose of this article is to explore the development space of art design education in colleges and universities in order to deliver a steady stream of fresh talents for national construction, market operation, and enterprise development.This article analyzes the problems and blind spots in art education by discussing the status quo of art design education in some universities in province a.It is concluded that 73.08% of college art design education lacks standardization; 65.38% of colleges and universities emphasize on mastering technology and cultivating creativity.Targeted development strategies are provided to provide a wider space for the education of art students in order to develop our art education cause construction and improve the art talent training environment.

Journal: Journal of Physics: Conference Series (2020)
Publication types: Conference Abstract/Paper;
Discussion on the Cultivation Mode of Contemporary Art Talents in Universities Based on the Internet Technology in the New Era

At present, with the development of the economy and society, the demand for applied, compound and skilled talents is increasingly strong.In the higher education connotation development is advancing steadily, the “double first-class” construction is accelerating; the high-level university is accelerating the construction of today.This may be related to the lack of scientific orientation of the training program of art majors in universities in our province.Therefore, there is a distance between the cultivation program of art professionals in universities in our province and the development of social economy.

Journal: Journal of Physics: Conference Series (2020)
Publication types: Conference Abstract/Paper;
Opportunities Challenges Countermeasures: Physical Health Promotion of College Students in the Era of Big Data

The physical health of college students is an important issue related to the output of qualified talents in colleges and universities.The research methods such as the literature method are used to analyze the opportunities and challenges faced by the physical health promotion of college students in the big data era.Help to provide self-real-time monitoring and timely and effective diagnosis; self-media communication can help provide more scientific guidance; the scientific use of big data can assist in the comprehensive management of problems.The main challenges are mainly from the difficulty of college physical education curriculum reform and the weakness of students’ physical consciousness, and put forward countermeasures.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
Research on Brand Image Design Innovation and Practice under the New Retail Trend Based on Computer Technology

With the rapid iteration of the computer internet, the conventional brand image design has been unable to adapt to the development of market retail mode and mode, and innovation and reform are urgently needed.Based on this, this paper first analyzes the challenges of brand image design under the background of new retail, then studies the innovative principles of brand image design under the new retail trend based on computer technology, and finally gives the ideas and methods of innovation and practice.

Journal: Journal of Physics: Conference Series (2020)
Publication types: Conference Abstract/Paper;
Optimization of dyes and toxic metals removal from environmental water samples by clinoptilolite zeolite using response surface methodology approach

The present study aimed to remove crystal violet (cv), malachite green (mg), cd(ii), and pb(ii) from an aqueous solution using clinoptilolite zeolite (cz) as an adsorbent.Response surface methodology (rsm) based on central composite design (ccd) was used to analyze and optimize the process parameters, such as p h, analyte concentration, adsorbent amount, and sonication time.Quadratic models with the coefficient of determination (r 2 ) of 0.99 ( p &lt; 0.0001) were compared statistically.The results revealed that the selected models have good precision and a good agreement between the predicted and experimental data.The maximum removal of contaminants was achieved under optimum conditions of p h = 6, sonication time of 22 min, the adsorbent amount of 0.19 g, and analyte concentration of 10 mg l −1 .The reusability test of the adsorbent showed that the cz adsorbent could be used 5 times in water and wastewater treatment processes.According to the results of interference studies, the presence of different ions, even at high concentrations, does not interfere with the removal of contaminants.Applying the cz adsorbent on environmental water samples revealed that cz adsorbent could remove cv, mg, cd(ii), and pb(ii) in the range of 84.54% to 99.38% and contaminants present in industrial effluents.As a result, the optimized method in this study can be widely used with high efficiency for removing cv, mg, cd(ii), and pb(ii) from water and wastewater samples.

Journal: Scientific Reports (2022)
Publication types: Research Article;
Research on User Data Analysis of Agricultural Product E-commerce Based on Big Data Technology

With the rapid development of rural e-commerce, users will produce a large amount of disordered original log data on the platform.In order to give full play to the user data value of agricultural e-commerce, this paper combs the concepts of big data and user data of agricultural e-commerce, and presents the user data analysis service and application system architecture of agricultural e-commerce based on big data technology, so that big data can be used in agriculture.The application value in the field of commodity e-commerce has been fully embodied, which has played a role in promoting the further development of e-commerce.

Journal: Journal of Physics: Conference Series (2019)
Publication types: Conference Abstract/Paper;
Research on Information Management Model of Petroleum Enterprises under the Big Data Background

Application of big data is analysed via the present information management of petroleum enterprises in this paper.The logical structure and application architecture are proposed based on hodiernal production, administration and management of oil firms in china and mainstream big data technology.Meanwhile, future applications of the information management are looked ahead under big data environment.

Journal: Journal of Physics: Conference Series (2019)
Publication types: Conference Abstract/Paper;
Research on Supply Chain Inventory Replenishment and Pricing Model Based on Time in Big Data Environment

Inventory management is an important link in the whole supply chain.Raw materials, semi-finished products and finished products in the supply chain may form inventory.Generally speaking, the inventory cost will reach about 20% - 40% of the value of these goods.Therefore, it is very important to control the inventory quantity of goods in the supply chain to reduce the inventory cost and capital occupation.With the development of supply chain in big data, people begin to seek the minimization of total cost of supply chain and the maximization of customer service level.In the big data environment, the connotation of inventory management has also changed dramatically, which requires enterprises to shift from the traditional focus on their own inventory management to the inventory control of the whole supply chain.There are many inventory management schemes in the supply chain environment.In recent years, the more advanced one is vendor managed inventor (vmi).However, due to the limited level of cooperation between suppliers and retailers in vmi, it has its own limitations.Big data internet can break this limitation.The joint inventory management model can achieve this win-win partnership, which provides a breakthrough in traditional management methods for supply chain inventory management.

Journal: Journal of Physics: Conference Series (2020)
Publication types: Conference Abstract/Paper;
Alkannin represses growth of pancreatic cancer cells based on the down regulation of miR-199a

Alkannin displays tumor suppressive activity by initiating apoptosis.Here, we corroborated its role in pancreatic carcinoma (panc‐1) cells and addressed the molecular mechanism in which micro rna‐199a (mi r‐199a) and klotho might be implicated.Panc‐1 and min6 cells were treated by alkannin and its role was evaluated in cellular viability.Next we assessed the ability of panc‐1 cells to proliferate, migrate, and invade as well as apoptosis process.Besides, proliferating cell nuclear antigen (pcna), cyclin d1, p53, and caspases were quantified using western blot.Mi r‐199a was detected by q rt‐pcr.Mi r‐199a‐silenced or ‐replenished cells were established to study its function role in klotho in conjunction with alkannin.Further, klotho‐overexpressed or ‐silenced cells were constructed to investigate the alteration of m tor and mek/erk pathways.Alkannin repressed the viability of panc‐1 cells instead of min6 cells.Alkannin counteracted the growth of panc‐1 cells through inhibiting proliferation, migration, and invasion and facilitating apoptosis, which was evidenced by the modulation on pcna, cyclin d1, p53, and cleavage of caspases.The silence of mi r‐199a by alkannin was also involved in the antitumor process.Alkannin enhanced klotho expression possibly through silencing mi r‐199a.Besides, m tor and mek/erk signaling were counteracted by klotho overexpression while facilitated by its silence.Alkannin inhibited the growth of panc‐1 cells via modulating mi r‐199a‐klotho node.During this process, m tor and mek/erk pathways were blunted.

Journal: Biofactors (2020)
Publication types: Research Article;
Emodin relieved lipopolysaccharide-evoked inflammatory damage in WI-38 cells by up-regulating taurine up-regulated gene 1

Background neonatal pneumonia (np) has a high fatality rate in neonatal illness.This research investigated the functions of emodin on lipopolysaccharide (lps)‐evoked inflammatory injury in wi‐38 cells.Methods cell counting kit‐8 (cck‐8) assay and flow cytometry were utilized for examining the impacts of lps and emodin on viability and apoptosis, respectively.Taurine up‐regulated gene 1 (tug1) level was altered through cell transfection and investigated by reverse transcription quantitative polymerase chain reaction (rt‐q pcr).Moreover, rt‐q pcr, western blot and enzyme‐linked immunosorbent assay (elisa) were utilized for investigating expressions of monocyte chemoattractant protein‐1 (mcp‐1) and interleukin (il)‐6.Western blot was carried out for investigating the levels of bcl‐2, bax, pro‐caspase‐3, cleaved‐caspase‐3 and nf‐κb and p38mapk pathway‐related proteins.Results lps treatment restrained cell viability, enhanced apoptosis, and expressions of inflammation‐related il‐6 and mcp‐1.Emodin alleviated lps‐evoked inflammatory injury and restrained the nf‐κb and p38mapk pathways.Furthermore, emodin positively regulated tug1 expression and tug1 silencing could reverse the efficacy of emodin on il‐6 and mcp‐1 expressions.Finally, tug1 regulates the expression of inflammatory factors through nf‐κb and p38mapk pathways.Conclusion emodin alleviated lps‐evoked inflammatory injury by raising tug1 expression via nf‐κb and p38mapk pathways in wi‐38 cells.

Journal: Biofactors (2020)
Publication types: Research Article;
Long noncoding RNA Mirt2 prohibits lipopolysaccharide-evoked HK-2 cell injury via modulation of microRNA-126

Long noncoding rna myocardial infarction‐associated transcript 2 (lnc rna mirt2) is a burgeoning lnc rna, its anti‐inflammatory capacity has been testified.Nonetheless, the functions of mirt2 in immunoglobulin a nephropathy are unexplored.We tried to impart the influences of mirt2 in lipopolysaccharide (lps)‐evoked hk‐2 cells damage.Hk‐2 cells were manipulated with 10 ng/ml lps, next cell viability, apoptosis, reactive oxygen species (ros) generation, pro‐inflammatory factors and mirt2 expression were evaluated.After pc‐mirt2 vector transfection, the aforementioned trials were performed.Meanwhile, real‐time quantitative polymerase chain reaction (pcr) experiment was used to detect mi r‐126 expression.Subsequently, functions of mi r‐126 in lps‐treated hk‐2 cells were further delved after transfection with mi r‐126 mimic.Western blot was used to evaluate nf‐κb pathway.The data showed that lps invoked hk‐2 cells inflammatory damage via the suppression of cell viability and the acceleration of apoptosis, ros level, and il‐1β and il‐6 secretion.Lps inhibited mirt2 expression and overexpression of mirt2 mitigated lps‐caused inflammatory damage in hk‐2 cells.Additionally, overexpression of mirt2 repressed mi r‐126 expression in lps‐stimulated cells.Meanwhile the anti‐inflammatory effect of mirt2 was inverted by upregulating mi r‐126 expression.Besides, overexpressed mirt2 retarded lps‐activated nf‐κb pathway via repressing mi r‐126.The research certified the anti‐inflammatory impacts of mirt2 on lps‐impaired hk‐2 cells.

Journal: Biofactors (2019)
Publication types: Research Article;
Quercetin alleviates lipopolysaccharide-induced inflammatory responses by up-regulation miR-124 in human renal tubular epithelial cell line HK-2

Chronic kidney disease (ckd) is a persistent kidney structural and functional disorder.Quercetin is one of active extracted flavonoids and has protective effects.Therefore, we proposed to survey the effect of quercetin on ckd.Hk‐2 cells were preprocessed by quercetin and then irritated with lipopolysaccharide (lps).Cck‐8 assay and flow cytometry were utilized to test viability and apoptosis.Elisa assay was utilized to estimate the il‐6 and tnf‐α secretion.Western blot was performed to examine the expression of apoptosis and inflammation‐associated mediators.After that hk‐2 cells were transfected by mi r‐124 inhibitor.And the above‐mentioned parameters were reassessed.Lps stimulated apoptosis and declined viability in hk‐2 cells.Additionally, lps stimulated inflammatory responses.Meanwhile, quercetin attenuated lps‐stimulated apoptosis, production of il‐6, and tnf‐α in experimental cells.Subsequently, my d88 and mi r‐124 expression was elevated by lps and alleviated by quercetin.Finally, quercetin exerted its protective function through nf‐κb pathway via up‐regulating mi r‐124.Our data demonstrated that quercetin reduced apoptosis and inflammation stimulated by lps in hk‐2 cells.Moreover, quercetin alleviated lps‐stimulated injury by up‐regulating mi r‐124.

Journal: Biofactors (2019)
Publication types: Research Article;