syedzayyan/paper_mill_benchmark huggingface dataset:
Technology readiness and UTAUT2 in e-wallet adoption in a developing country.

An e-wallet is a digital equivalent of a physical wallet which plays an essential role in payment system transformation.To embrace the concept of a cashless society, the malaysian government and central bank have taken various steps to encourage the adoption of e-wallets.Despite the seamless services offered by the e-wallet, it is yet to reach high-scale adoption in malaysia.This study aims to investigate malaysians' readiness towards the e-wallet and their perceptions of it by employing the utaut2 model.methods:a total of 309 valid data were gathered and analysed with partial least squares structural equation modelling (pls-sem).results:the findings revealed that the respondents were confident about the new technology and tended to believe that e-wallet was somehow useful for them.The results also disclosed that e-wallet adoption intention was significantly influenced by performance expectancy, price value, facilitating conditions, and followed closely by social influence.Nonetheless, insecurity did not present significant impact on both performance expectancy and effort expectancy of e-wallet.conclusions:this study provides a substantial contribution to the knowledge domain by combining system-specific and individual-specific models in an e-wallet context.The outcomes of this study would also benefit e-wallet service providers and policymakers by delivering holistic insight into malaysians' readiness and adoption behaviour of the e-wallet.

Journal: F1000Research (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Photonic metacrystal: design methodology and experimental characterization.

We report a design methodology for creating high-performance photonic crystals with arbitrary geometric shapes.This design approach enables the inclusion of subwavelength shapes into the photonic crystal unit cell, synergistically combining metamaterials concepts with on-chip guided-wave photonics.Accordingly, we use the term "photonic metacrystal" to describe this class of photonic structures.Photonic metacrystals exploiting three different design freedoms are demonstrated experimentally.With these additional degrees of freedom in the design space, photonic metacrystals enable added control of light-matter interactions and hold the promise of significantly increasing temporal confinement in all-dielectric metamaterials.

Journal: Optics express (2022)
Publication types: Journal Article
Concurrent suppression of Aβ aggregation and NLRP3 inflammasome activation for treating Alzheimer's disease.

Alzheimer's disease (ad) is a neurodegenerative illness accompanied by severe memory loss, cognitive disorders and impaired behavioral ability.Amyloid β-peptide (aβ) aggregation and nucleotide-binding oligomerization domain (nod)-like receptor protein 3 (nlrp3) inflammasome play crucial roles in the pathogenesis of ad.Aβ plaques not only induce oxidative stress and impair neurons, but also activate the nlrp3 inflammasome, which releases inflammatory cytokine il-1β to trigger neuroinflammation.A bifunctional molecule, 2-[2-(benzo[d]thiazol-2-yl)phenylamino]benzoic acid (bpba), with both aβ-targeting and inflammasome-inhibiting capabilities was designed and synthesized.Bpba inhibited self- and cu2+- or zn2+-induced aβ aggregation, disaggregated the already formed aβ aggregates, and reduced the neurotoxicity of aβ aggregates; it also inhibited the activation of the nlrp3 inflammasome and reduced the release of il-1βin vitroandvivo.Moreover, bpba decreased the production of reactive oxygen species (ros) and alleviated aβ-induced paralysis in transgenic c.Eleganswith the human aβ42gene.Bpba exerts an anti-ad effect mainly through dissolving aβ aggregates and inhibiting nlrp3 inflammasome activation synergistically.

Journal: Chemical science (2022)
Publication types: Journal Article
Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia.

Alopecia has become an exceedingly prevalent dermatological disorder.Etiologically, infection (bacterial and fungal infection), inflammation, and immune dysregulation are the main causes of immune-mediated hair loss.Treating hair loss has remained challenging as the available therapies are limited.Exosomes from adipose-derived stem cells (adsc-exos) have been used for treating neurodegenerative diseases and autoimmune diseases and in wound-healing treatments.However, the function and mechanism of adsc-exos in alopecia treatment remain unclear.This study is aimed at investigating the effects of adsc-exos on hair growthin vitroandin vivofor potentially treating immune-mediated alopecia and further exploring the underlying mechanism.Methods cell proliferation, migration, and apoptosis of dermal papilla cells (dpcs) that were treated with adsc-exos were detected using the cell counting kit-8 (cck-8) assay, scratch wound-healing assay, and flow cytometry assay, respectively.A c57bl/6 hair-depilated mouse model was establishedin vivo; then, adsc-exos were subcutaneously injected alone or in combined with minoxidil.The effects of adsc-exos on hair growth, pathological changes, and the related mechanism were investigated by he staining, quantitative real-time pcr (q rt-pcr), western blotting, and rna sequencing (rna-seq).Results adsc-exos significantly promoted dpc proliferation and migration while also reducing apoptosis.In addition, compared with the control group, adsc-exos-treated mice had better hair growth, more hair follicles (hfs) and thicker dermis.Rna-seq revealed that the mi r-22 and tnf-αsignaling pathways were markedly downregulated in dpcs after adsc-exos treatment.In addition, according to q rt-pcr and western blotting results, the wnt/β-catenin signaling pathway was activated in the skin of adsc-exos-treated mice.Conclusion adsc-exos therapy positively affected the promotion of hair regrowth by regulating mi r-22, the wnt/β-catenin signaling pathway, and the tnf-αsignaling pathway, implying that adsc-exos could be a promising cell-free therapeutic strategy for immune-mediated alopecia.

Journal: Journal of immunology research (2022)
Publication types: Journal Article
Incidence of dementia in a population cohort of older people from São Paulo, Brazil.

S to estimate the incidence of dementia in a community-dwelling older population from são paulo city, brazil.Methods/design this two-phase prospective cohort study evaluated a representative cluster sample of 1370 individuals aged 60 years old and over from three different socioeconomic levels.The community screening phase consisted of a tested combination of cognitive and functional tests administered among the subjects and informants.In the hospital diagnosis phase, the cambridge examination was performed; the diagnosis of dementia and dementia subtypes was made according to dsm iv criteria.Incidence rates were expressed in person-years, multiplied by 1000.The risk of developing dementia was calculated using cox regression.Results among 1370 eligible subjects, 678 were accessed, and 489 completed the evaluation.Forty-two subjects were diagnosed with dementia.The incidence rate of dementia and alzheimer's disease (ad) were 11.2 (95% ci: 8.0-15.1) and 8.9 (95% ci: 6.1-12.5) per 1000 person-years, respectively; there were high age-specific rates of dementia among younger individuals.There was a trend of a higher risk of developing ad for women than for men.Multivariate analysis showed that older age, the presence of diabetes and the presence of amnestic mci increased the risk of developing dementia.Conclusions the age-specific rates in younger individuals were expressively higher than in worldwide studies and supposedly affected by cardiovascular morbidity.The higher risk in women in a younger sample corroborated the interaction between sex and ad.The increased risk of amnestic mci reinforced its contribution to the progression to dementia and ad.

Journal: International journal of geriatric psychiatry (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Low-dose ketamine infusion in treatment-resistant double depression: Revisiting the adjunctive ketamine study of Taiwanese patients with treatment-resistant depression.

Whether a single low-dose ketamine infusion may have rapid antidepressant and antisuicidal effects in patients with treatment-resistant double depression remains unclear.Methods this study enrolled 35 patients with treatment-resistant double depression, 12 of whom received 0.5 mg/kg ketamine, 11 received 0.2 mg/kg ketamine, and 12 received normal saline as a placebo.The patients were assessed using the 17-item hamilton rating scale for depression (hdrs) prior to the initiation of infusions, at 40 and 240 min post-infusion, and sequentially on days 2-7 and on day 14 after ketamine or placebo infusions.Results a single 0.5 mg/kg ketamine infusion had rapid antidepressant (p = 0.031, measured by the hdrs) and antisuicidal (p = 0.033, measured by the hdrs item 3 scores) effects in patients with treatment-resistant double depression.However, 0.2 mg/kg ketamine was insufficient to exert rapid antidepressant and antisuicidal effects in this patient population with severe and chronic illness.Discussion in this patient population, the commonly used dose of 0.5 mg/kg was sufficient.Additional studies are required to investigate whether repeated infusions of low-dose ketamine may also maintain antidepressant and antisuicidal effects in patients with treatment-resistant double depression.

Journal: Human psychopharmacology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Measurement of dielectric properties of cells at single-cell resolution using electrorotation.

Dielectric properties of a cell are biophysical properties of high interest for various applications.However, measuring these properties accurately is not easy, which can be exemplified by the large variations in reported dielectric properties of the same cell types.This paper presents a method for measuring the dielectric properties of cells at high frequency, especially lipid-producing microalgae, at single-cell resolution, by integrating an electrorotation-based dielectric property measurement method with a negative dielectrophoretic (n dep) force-based single-cell trapping method into a single device.In this method, a four-electrode n dep structure was used to trap a single cell in an elevated position in the center of another four-electrode structure that can apply electrorotational force.By measuring the speed of cell rotation under different applied electrorotation frequencies and fitting the results into a theoretical core-shell cell model, the dielectric properties of cells, including membrane capacitance and cytoplasm conductivity, could be obtained.This system was applied to measure the dielectric properties of lipid-accumulating microalga chlamydomonas reinhardtii strain sta6 by applying an electrorotation signal of up to 100 mhz.By utilizing a broad frequency range and expanding the measurement spectra to a high frequency region, increased accuracy in fitting the dielectric parameters to a theoretical model was possible, especially the cytoplasm conductivity.The developed method can be used in various applications, such as screening microalgae based on their lipid production capabilities, separating cells of different dielectric properties, identifying different cell types, as well as conducting basic biophysical analyses of cellular properties.

Journal: Biomedical microdevices (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.
Validation of teleaudiology hearing aid rehabilitation services for adults: a systematic review of outcome measurement tools.

To investigate outcome measurement tools for the validation of teleaudiology hearing aid rehabilitation services for adults.Methods a search strategy was developed to identify tools used to evaluate standard and teleaudiology hearing aid rehabilitation services for adults.A seven-domain hearing-health-care service model for validation was defined and used to analyse the applicability and suitability of patient- and service-centred tools.This model and the applicability and suitability criteria were based on the literature, the international classification of functioning (icf) framework, and gold standard professional practice guidelines, which together formed the validation framework used in this study.Results eighteen tools were identified and assessed against the validation framework.These tools were found to primarily assess aspects in the patient communication domain and rarely in the domain of service provision.All the included tools had some applicable items for teleaudiology hearing aid services; three tools were judged as suitable and four partially suitable for validating these services.Conclusion although there is a set of suitable tools available to validate teleaudiology hearing aid rehabilitation services, none of them cover all the seven domains of the validation model used by this review and few are focussed on a specific domain.Further improvement and/or development of new tools to comprehensively validate these services is still necessary.At this stage, this still limits clinical audiology practice research, especially in teleaudiology.implications for rehabilitationoutcome measurement tools are crucial for assessing the validity of hearing rehabilitation services.findings of this study inform clinicians and researchers on how and what to assess and use to evaluate teleaudiology and standard hearing aid rehabilitation services.the use of the proposed validation framework may facilitate the standardisation of validation of both face-to-face and remotely delivered audiology rehabilitation services and improve consistency of methodology and reported real-world outcomes across studies and thus, the evidence.

Journal: Disability and rehabilitation (2022)
Publication types: Journal Article;Systematic Review;Research Support, Non-U.S. Gov't
Cyberchondria, Covid-19 phobia, and well-being: a relational study on teachers.

This study aims at investigating level and contributor factors of cyberchondria, covid-19-related phobia, and well-being in a sample of teachers in turkey.Methods the study was conducted on teachers (n=1000) working in a province in eastern turkey.Data for the study were collected using a form that included participants' descriptive characteristics, the covid-19 phobia scale (c19p-se), the cyberchondria severity scale, and the world health organization-5 well-being index (who-5).Spearman correlation analysis, mann-whitney u test, and kruskal wallis analysis of variance were used to analyze the data.Results as participant's cyberchondria levels rose, c19p-se scores increased (r=0.271, p<0.001), and who-5 scores decreased (r=-0.224, p<0.05).Corona-phobia was higher in those who used social media than in those who did not (p<0.05).Cyberchondria scale scores were higher among those who had taken medications without a physician's recommendation during the pandemic.Participants who had a disabled person or a person in need of care in their household had higher scores for distrust of the physician and c19p-se than for the cyberchondria severity scale sub-dimension, and the who-5 mean scores were lower (p<0.001, p=0.016, and p=0.020, respectively).Conclusions the study results show that increasing levels of cyberchondria trigger covid-19 phobias in teachers during the covid-19 pandemic and negatively affect their well-being.This descriptive study can help understand the risk group for cyberchondria, the influencing factors, and the health and economic consequences, and identify strategies for effective combating with cyberchondria.

Journal: La Medicina del lavoro (2022)
Publication types: Journal Article
Vascular Pathology and Impact of Stent Eccentricity for Stent Restenosis in Femoropopliteal Endovascular Therapy.

To explore the clinical features associated with stent eccentricity and reveal the impact of stent eccentricity on the risk of 1-year restenosis after femoropopliteal stent implantation for symptomatic atherosclerotic peripheral artery disease (pad).Materials and methods the clinical database of a multicenter prospective study was used.It registered 2,018 limbs of 1,766 patients in whom intravascular ultrasound (ivus)-supported femoropopliteal endovascular therapy (evt) for symptomatic atherosclerotic pad was planned from november 2015 to june 2017.The study included 1,233 limbs of 1,088 patients implanted with a bare nitinol stent, drug-eluting stent (des), or stent graft and administered ≥2 antithrombotic drugs.The stent eccentricity was evaluated using ivus, calculated as [(maximum diameter) / (minimum diameter) - 1] at the cross-sectional segment with the lowest lumen area after stent implantation.Results chronic total occlusion and bilateral arterial calcification (peripheral artery calcification scoring system grades 3 and 4) were positively associated with stent eccentricity, whereas renal failure while receiving dialysis, des use, and stent graft use were negatively associated with stent eccentricity (all p < .05).Stent eccentricity was associated with an increased risk of 1-year restenosis (odds ratio [or], 1.18; 95% ci, 1.01-1.37; p = .034).However, after adjustment for lesion severity and implanted stent types, the association was no longer significant (or, 1.07; 95% ci, 0.91-1.24; p = .43).Conclusions stent eccentricity was not significantly associated with the risk of 1-year restenosis after femoropopliteal evt.

Journal: Journal of vascular and interventional radiology : JVIR (2022)
Publication types: Journal Article;Multicenter Study
RNA Editing-Associated Post-Transcriptional Gene Regulation in Rheumatoid Arthritis.

Rheumatoid arthritis (ra) is an autoimmune disease characterised by systemic inflammation of joints.The observed complexity of ra pathogenesis and studies that have been carried out so far indicate that ra pathogenesis is regulated at multiple levels.Given the role of rna editing in autoimmune disease, we hypothesised that rna editing could contribute to ra pathogenesis by regulating gene expression through post-transcriptional mechanisms.Methods we identified rna editing events in synovial tissues from early and established ra compared with normal subjects from an available transcriptome data set using reditools.To investigate the potential effect of these rna editing events on gene expression, we carried out an analysis of differential exon usage in the vicinity of the differentially edited sites using dexseq.We then used string to identify putative interactions between differentially edited genes identified from reditools analysis.We also investigated the possible effects of these rna editing events on mi rna-target m rna interactions as predicted by mi randa.Results our analysis revealed that there is extensive rna editing in ra, with 304 and 273 differentially edited events in early ra and established ra, respectively.Of these, 25 sites were within 11 genes in early ra, and 34 sites were within 7 genes in established ra.Dexseq analysis revealed that rna editing correlated with differential exon usage in 4 differentially edited genes that have previously also been associated with ra in some measure:atm,zeb1,anxa4, and timp3.Dexseq analysis also revealed enrichment of some non-functional isoforms of these genes, perhaps at the expense of their full-length counterparts.Network analysis using string showed that several edited genes were part of the p53 protein-protein interaction network.We also identified several putative mi rna binding sites in the differentially edited genes that were lost upon editing.Conclusions our results suggested that the expression of genes involved in dna repair and cell cycle, including atmand zeb1which are well-known functional regulators of the dna damage response pathway, could be regulated by rna editing in ra synovia.This may contribute to an impaired dna damage response in synovial tissues.

Journal: Bioinformatics and biology insights (2022)
Publication types: Journal Article
RUNX3-Mediated Immune Cell Development and Maturation.

The transcription factor runx3 is a prominent regulator of multiple hematopoietic cell lineages.Gene loss of function studies demonstrated the unique and essential roles of this master regulator in differentiated lymphoid and myeloid cells.As a complementary approach, runx3 was upregulated in various leukocyte subsets to probe the instructive role of this 'multilineage'-specific transcription factor.In this report, we overview the immunomodulatory functions of runx3 within the hematopoietic compartment to gain insight into the consequences of runx3 deletion or overexpression in committed immune cells.Genetic studies revealed the essential role of runx3 in langerhans cell development.Moreover, this transcription factor is necessary for the differentiation and maintenance of the cytotoxic cd8+ t cells.In addition, t helper, natural killer, and b cells are also influenced by runx3.Importantly, the ectopic expression of runx3 enhances the immunogenicity of cytotoxic t cells and pluripotent stem-cell-derived dendritic cells, suggesting that this protein can be applied in cell-based immunotherapies.

Journal: Critical reviews in immunology (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
The Prevalence of Work-Related Musculoskeletal Disease Among Pediatric Ophthalmologists.

Introduction work-related musculoskeletal disease (msd) is the second leading cause of disability globally.Ophthalmologists widely report msds in the neck (70%) and back pain (40-80%).Our study intended to identify the prevalence of msds among pediatric ophthalmologists.Methods pediatric ophthalmologists self-reported chronic pain, instrumentation used, years practiced, surgeries performed, work schedule/environment modifications due to msd, and treatment for msd via an anonymous online survey.Statistical analysis of responses included odds ratios, pearson chi-square testing, and spearman correlations.Results this study had 101 respondents, with 66% reporting chronic pain.Chronic neck pain (41%) and lower back pain (31%) followed by shoulder pain (30%) were the leading msd complaints and significantly correlated with years of experience (p<0.05).Participants often had multiple types of pain, including 13% of the sample who experienced all three types of pain.Those reporting shoulder and back pain also reported a greater incidence in work modification (68-83%).Those suffering from chronic neck, shoulder, and lower back pain have sought treatment for their msd (p<0.05).Discussion with such wide reporting of chronic neck, back, and shoulder pain, the development of msds likely leads to disability.Ergonomic innovations in the workplace may reduce the healthcare burden and prolong pediatric ophthalmologists' ability to provide services.Conclusion in our study, the reported prevalence of chronic neck and back pain was comparable to previous studies and published literature, with 2/3 of participants reporting pain.There is a tremendous need for ongoing innovations, especially surgical loupes, operating microscopes, and slit-lamp modifications to prevent musculoskeletal disease.

Journal: Clinical ophthalmology (Auckland, N.Z.) (2022)
Publication types: Journal Article