syedzayyan/paper_mill_benchmark huggingface dataset:
Bleeding risk of variceal band ligation in extrahepatic portal vein obstruction is not increased by oral anticoagulation.

And objectives noncirrhotic nontumoral extrahepatic portal vein obstruction (ehpvo) is the second leading cause of portal hypertension (pht) and is mainly related to prothrombotic disorders.Patients with ehpvo often require prolonged oral anticoagulation therapy (oat) together with variceal band ligation (vbl) to prevent thrombosis recurrence and pht-related bleeding, respectively.The benefit-risk balance of vbl in this context remains unknown.We aimed to assess upper gastrointestinal bleeding (ugb) risk and variceal eradication efficacy in ehpvo patients undergoing a vbl program without stopping oat.Patients and methods all patients with ehpvo treated (group a) or not (group b) with oat and undergoing the vbl program were included between 2001 and 2010 in two tertiary french liver centers.We compared the incidence, source, and severity of ugb and variceal eradication efficacy.All ehpvo patients were then matched 1 : 1 with compensated cirrhotic patients with pht not receiving oat (group c) to compare ugb incidence and vbl efficacy.Results forty-three ehpvo patients (30 with and 13 without oat) and 43 cirrhotic patients were included for a total of 471 vbl sessions.The incidence of ugb was similar between group a (nine episodes/121 sessions) and group b (6/130), and tended to be higher in ehpvo patients (group a and b) than in cirrhotic patients (2/220).There was no difference between groups when considering bleeding source or severity and variceal eradication efficacy (84%).Conclusion vbl can be performed safely and efficiently without stopping anticoagulation therapy in ehpvo patients.

Journal: European journal of gastroenterology & hepatology (2018)
Publication types: Journal Article;Multicenter Study;Observational Study
A comparative study of a thermoelastic problem for an infinite rigid cylinder with thermal properties using a new heat conduction model including fractional operators without non-singular kernels.

In this research, two alternative approaches to fractional derivatives, namely caputo-fabrizio (cf) and atangana-baleanu (ab) fractional operators, are used to propose a generalized model of thermoelastic heat transfer of a rigid cylinder with thermal characteristics.The proposed model can be constructed by combining the dpl model with phase delays and the two temperature theories.It will be taken into account that the solid cylinder has variable physical properties.It was also assumed that the surface of the cylinder is penetrated by a continuous magnetic field and is regularly exposed to thermal loading from a continuous heat source.The numerical solutions of the studied physical fields in the ab and cf fractional derivative cases were derived using the laplace transform method and are compared visually and tabularly and discussed in detail.

Journal: Archive of applied mechanics = Ingenieur-Archiv (2022)
Publication types: Journal Article
Cervical lymphatic malformations amenable to transhairline robotic surgical excision in children: A case series.

Lymphatic malformations are rare benign malformations that predominantly occur in the head and neck region.The advent of surgical robots in head and neck surgery may provide beneficial outcomes for pediatric patients.Here, we describe our experiences with transhairline incisions for robot-assisted surgical resection of cervical lymphatic malformations in pediatric patients.in this prospective longitudinal cohort study, we recruited consecutive patients under 18 years of age who were diagnosed with congenital cervical lymphatic malformations and scheduled for transhairline approach robotic surgery at a single medical center.We documented the docking times, console times, surgical results, complications, and postoperative follow-up outcomes.the studied patients included 2 with mixed-type lymphatic malformations and 2 with macrocystic-type lymphatic malformations.In all 4 patients, the incision was hidden in the hairline; the incision length was <5 cm in 3 patients but was extended to 6 cm in 1 patient.Elevating the skin flap and securely positioning it with yang retractor took <1 hour in all cases.The mean docking time was 5.5 minutes, and the mean console time was 1 hour and 46 minutes.All 4 surgeries were completed endoscopically with the robot.The average total drainage volume in the postoperative period was 21.75 m l.No patients required tracheotomy or nasogastric feeding tubes.Neither were adverse surgery-associated neurovascular sequelae observed.All 4 patients were successfully treated for their lymphatic malformations, primarily with robotic surgical excisions.cervical lymphatic malformations in pediatric patients could be accessed, properly visualized, and safely resected with transhairline-approach robotic surgery.Transhairline-approach robotic surgery is an innovative method for meeting clinical needs and addressing esthetic concerns.

Journal: Medicine (2021)
Publication types: Journal Article
Are psychological interventions efficacious for adults with migraine? A systematic review and meta-analysis.

To determine the efficacy of psychological interventions in studies of adults with migraine, in reducing pain, and functional and psychosocial difficulties.Background a recently published cochrane review showed no strong evidence for psychological intervention for adults with migraine.However, this review was limited by stringent inclusion criteria, potentially resulting in low power.The current review examines the stability of these findings.Methods central, medline, embase, psyc info, and cinahl databases were systematically searched from inception to july 31, 2021.Reviewers independently conducted the search and extraction process.Risk of bias was conducted, and we provide grade ratings of our confidence in the evidence.We included 39 randomized controlled trials in the meta-analyses (n = 3155); 31 included data on migraine only and eight combined data from adults with migraine or tension-type headache (tth).Results in contrast to the cochrane review, for studies including adults with migraine only, we found psychological interventions had a small to medium beneficial effect on improving migraine frequency, pain intensity, and disability post-treatment, compared to controls (cohen's d range 0.23 to 0.33), and disability at follow-up (d = 0.44).We found no evidence of a beneficial effect on quality-of-life post-treatment, or mood at post-treatment or follow-up.Our sensitivity analyses on studies with mixed headache populations (migraine and combined migraine/tth) found a similar magnitude of effects for most outcomes (d range 0.25 to 0.36), except for mood, which produced a small to medium beneficial effect (d = 0.32).Conclusion we found evidence that adults with migraine may benefit from psychological intervention, and psychological treatment may equally benefit adults with a range of headache conditions.However, as with previous reviews, quality of the evidence was low, findings should be cautiously interpreted, and this field would benefit from future high-quality trials.

Journal: Headache (2022)
Publication types: Journal Article;Meta-Analysis;Review;Systematic Review
High-resolution phenotyping of sorghum genotypic and phenotypic responses to low nitrogen and synthetic microbial communities.

Much effort has been placed on developing microbial inoculants to replace or supplement fertilizers to improve crop productivity and environmental sustainability.However, many studies ignore the dynamics of plant-microbe interactions and the genotypic specificity of the host plant on the outcome of microbial inoculation.Thus, it is important to study temporal plant responses to inoculation in multiple genotypes within a single species.With the implementation of high-throughput phenotyping, the dynamics of biomass and nitrogen (n) accumulation of four sorghum genotypes with contrasting n-use efficiency were monitored upon the inoculation with synthetic microbial communities (syn coms) under high and low-n.Five syn coms comprising bacteria isolated from field grown sorghum were designed based on the overall phylar composition of bacteria and the enriched host compartment determined from a field-based culture independent study of the sorghum microbiome.We demonstrated that the growth response of sorghum to syn com inoculation is genotype-specific and dependent on plant n status.The sorghum genotypes that were n-use inefficient were more susceptible to the colonization from a diverse set of inoculated bacteria as compared to the n-use efficient lines especially under low-n.By integrating high-throughput phenotyping with sequencing data, our findings highlight the roles of host genotype and plant nutritional status in determining colonization by bacterial synthetic communities.

Journal: Plant, cell & environment (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
Efficacy of different dexamethasone routes and doses in reducing the postoperative sequelae of impacted mandibular third-molar extraction: A network meta-analysis of randomized clinical trials.

The aim of this network meta-analysis was to assess the comparative effects of different dexamethasone (dxm) routes and doses on reducing postoperative sequelae (pain, swelling, trismus) after surgical extraction of impacted mandibular third molars.Methods five databases were searched on september 22, 2021, for randomized controlled trials.Risk of bias (rob) was assessed using the cochrane rob 2 tool.Study heterogeneity, publication bias, and quality of evidence were investigated.Network meta-analyses were conducted (p < .05), and the p-score was used to rank comparisons of dxm doses and routes.Results thirty-four eligible studies were included.Eight studies had low rob, 21 had some concerns, and 5 had high rob.The certainty of evidence evaluated by the confidence in network meta-analysis tool indicated low to very low certainty in most comparisons.The results showed that most dxm route and dose combinations were superior to a placebo in reducing the postoperative sequelae 1 day after surgical extraction.The results also showed that a 4-mg dxm submucosal injection substantially reduces pain 3 days after extraction compared with a 4-mg twin-mix or 8-mg intramuscular injection.Overall, it appears that 4 mg dxm submucosal injection or admixed with local anesthetic is effective in reducing postoperative sequelae after surgical extraction.Conclusions within the limitations of this study, the administration of dxm appears to be effective in reducing the postoperative sequelae, especially in the submucosal route.However, no noteworthy differences were found between the investigated dxm route and dose comparisons.Practical implications submucosal dxm injection effectively reduce postoperative sequelae of third-molar extractions.

Journal: Journal of the American Dental Association (1939) (2022)
Publication types: Meta-Analysis;Journal Article;Review
Image-Guided Percutaneous Pancreatic Duct Drainage: A 10-Year Observational Study.

To study the safety, efficacy, and long-term outcomes of percutaneous pancreatic duct drainage (ppdd) for treating pancreatic duct (pd) obstruction.Materials and methods this prospective observational cohort study included 73 patients with pd obstruction between december 2010 and june 2020.Patients underwent ppdd under ultrasound and fluoroscopy guidance, computed tomography (ct) and fluoroscopy guidance, or ct guidance only.They were categorized into 2 groups: nonmalignant (26 patients with pd obstruction due to acute and chronic pancreatitis or postoperative stricture) and malignant (47 patients with pancreatic head and ampullary tumors).Results the overall technical success rate was 98.6% (72/73).No major complications were encountered; however, severe weakness, lack of appetite, and tachycardia were observed in 4.1% (3/73) of patients, managed with intravenous resuscitation.Multivariate analysis demonstrated that diagnosis type (pancreatic head tumor: p = .049; odds ratio = 1.95 [1.11-2.25], and chronic pancreatitis: p = .048; odds ratio = 6.25 [1.74-22.22]) was associated with mortality.The median survival time was 16.3 months.Moreover, 15.1% (11/73) of the patients were alive 4 years after the ppdd procedure, and the mean overall survival time of nonmalignant and malignant patients was 35.1 and 21.4 months, respectively.Conclusions image-guided ppdd appears to be feasible and safe and provides a valuable therapeutic option for managing patients with pd obstruction.

Journal: Journal of vascular and interventional radiology : JVIR (2021)
Publication types: Journal Article;Observational Study
Low-temperature fusion using NH4HSO4and NH4HF2for rapid determination of Pu in soil and sediment samples.

Two fusion methods were established for rapid determination of pu in soil and sediment samples.The methods consisted of nh4hso4or nh4hf2fusion procedures incorporated with procedures for ca f2/la f3co-precipitation, extraction chromatography and sf-icp-ms measurement.The fusion procedures were done on a portable hot plate instead of in a cumbersome muffle furnace and took only 15 min heating-up time from room temperature to 250 °c and 15 min fusion time at 250 °c.Chemical recoveries of pu after completing the nh4hso4and nh4hf2fusion methods for 0.5-1 g sample were approximately 70% and more than 90%, respectively, and decreased with the increase of sample weight from 0.5 g to 5 g.Sediment samples were pre-ignited at different temperatures ranging from 450 °c to 1000 °c to form refractory fractions of pu, with which the dissolution rates of pu by the nh4hso4and nh4hf2fusion were investigated.With the increase of pre-ignition temperature of the sediment samples, the dissolution rates of pu from the samples prepared by nh4hso4fusion declined dramatically from near 100% for 450 °c to 8% for 1000 °c.In contrast, the nh4hf2fusion was capable of completely releasing pu from samples that were pre-ignited at temperatures over 450 °c to 1000 °c, which was comparable to releases obtained by the hazardous and time-consuming hno3-hf digestion, and was superior to the conventional hno3digestion.Additionally, because hf is not used in any procedure of the nh4hf2fusion, a safer and greener alternative to nh4hso4fusion and hno3-hf digestion is realized for rapid pu determination in environmental samples for nuclear emergency response and application in environmental studies.

Journal: Analytica chimica acta (2019)
Publication types: Journal Article
Rehabilitation is the Critical Ingredient to Optimize Return to Sport in Athletes.

Medical providers, rehabilitation specialists, and researchers must incessantly refine and adjust specific protocols, understanding that rehabilitation is the critical ingredient for return to sport in athletes.This month introduces a special issue in arthroscopy, sports medicine, and rehabilitation entitled "rehabilitation and return to sport in athletes." the articles have been authored by invited experts and rehabilitation specialists deemed thought leaders.The goal of the issue is to provide readers, researchers, and clinicians high-yield and high-impact articles that will optimize return to sport in athletes.For athletes, and non-athletes alike, there lies an essential quartet for recovery: 1) correct diagnosis, 2) restoration of anatomy, 3) biological healing, and 4) functional rehabilitation.Most importantly, a coordinated rehabilitation program must be chosen with appropriate specialization to synchronize the return to play.This special issue explores specific rehabilitation paradigms regarding return to sport using evidence-based medicine with support from literature to optimize the functional return of athletes.

Journal: Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association (2022)
Publication types: Editorial
Sports Activity and Arrhythmic Risk in Cardiomyopathies and Channelopathies: A Critical Review of European Guidelines on Sports Cardiology in Patients with Cardiovascular Diseases.

The prediction and prevention of sudden cardiac death is the philosopher's stone of clinical cardiac electrophysiology.Sports can act as triggers of fatal arrhythmias and therefore it is essential to promptly frame the athlete at risk and to carefully evaluate the suitability for both competitive and recreational sports activity.A history of syncope or palpitations, the presence of premature ventricular complexes or more complex arrhythmias, a reduced left ventricular systolic function, or the presence of known or familiar heart disease should prompt a thorough evaluation with second level examinations.In this regard, cardiac magnetic resonance and electrophysiological study play important roles in the diagnostic work-up.The role of genetics is increasing both in cardiomyopathies and in channelopathies, and a careful evaluation must be focused on genotype positive/phenotype negative subjects.In addition to being a trigger for fatal arrhythmias in certain cardiomyopathies, sports also play a role in the progression of the disease itself, especially in the case arrhythmogenic right ventricular cardiomyopathy.In this paper, we review the latest european guidelines on sport cardiology in patients with cardiovascular diseases, focusing on arrhythmic risk stratification and the management of cardiomyopathies and channelopathies.

Journal: Medicina (Kaunas, Lithuania) (2021)
Publication types: Journal Article;Review
A multiomics and network pharmacological study reveals the neuroprotective efficacy of Fu-Fang-Dan-Zhi tablets against glutamate-induced oxidative cell death.

Neuroprotective therapy after ischemic stroke remains a significant need, but current measures are still insufficient.The fu-fang-dan-zhi tablet (ffdzt) is a proprietary chinese medicine clinically employed to treat ischemic stroke in the recovery period.This work aims to systematically investigate the neuroprotective mechanism of ffdzt.A systems strategy that integrated metabolomics, transcriptomics, network pharmacology, and in vivo and in vitro experiments was used.First, middle cerebral artery occlusion (mcao) model rats were treated with ffdzt.Ffdzt treatment significantly reduced the infarct volume in the brains of middle cerebral artery occlusion (mcao) model rats.Then, samples of serum and brain tissue were taken for metabolomics and transcriptomics studies, respectively; gene expression profiles of mcf7 cells treated with ffdzt and its 4 active compounds (senkyunolide i, formononetin, drilodefensin, and tanshinone iia) were produced for cmap analysis.Computational analysis of metabolomics and transcriptomics results suggested that ffdzt regulated glutamate and oxidative stress-related metabolites (2-hydroxybutanoic acid and 2-hydroxyglutaric acid), glutamate receptors (nmdar, ka, and ampa), glutamate involved pathways (glutamatergic synapse pathway; d-glutamine and d-glutamate metabolism; alanine, aspartate and glutamate metabolism), as well as the reactive oxygen species metabolic process.Cmap analysis indicated that two active ingredients of ffdzt (tanshinone iia and senkyunolide i) could act as glutamate receptor antagonists.Next, putative therapeutic targets of ffdzt's active ingredients identified in the brain were collected from multiple resources and filtered by statistical criteria and tissue expression information.Network pharmacological analysis revealed extensive interactions between ffdzt's putative targets, anti-is drug targets, and glutamate-related enzymes, while the resulting ppi network exhibited modular topology.The targets in two of the modules were significantly enriched in the glutamatergic synapse pathway.The interactions between ffdzt's ingredients and important targets were verified by molecular docking.Finally, in vitro experiments validated the effects of ffdzt and its ingredients in suppressing glutamate-induced pc12 cell injury and reducing the generation of reactive oxygen species.All of our findings indicated that ffdzt's efficacy for treating ischemic stroke could be due to its neuroprotection against glutamate-induced oxidative cell death.

Journal: Computers in biology and medicine (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Immunohistochemical insights into a hidden pathology: Canine cryptorchidism.

Cryptorchidism is a common disorder in the canine population with some aspects still unclear.Although the bilateral condition is known to lead to fertility problems and predisposition to testicular cancer, the neoplastic risk for scrotal testis in unilateral cryptorchid dog is controversial.Therefore, the therapeutic approach to the canine unilateral cryptorchid is arbitrary so far.This study aimed to investigate precancerous testicular lesions, such as immaturity and atrophy, and compare them in scrotal and undescended testes using an in-depth diagnostic analysis based on immunophenotypic patterns.With this purpose, 26 adult male dogs of different ages and breeds, affected by unilateral or bilateral cryptorchidism were enrolled.After surgical removal, testes were examined immunohistochemically to assess their positivity for specific markers of the canine foetal/neonatal period, that is vimentin (vim), cytokeratin (ck), desmin (des), inhibin-α (inh), and anti-müllerian hormone (amh) in sertoli cells, and placental alkaline phosphatase (plap) in germ cells.Except for the ubiquitous vim, all the markers were more expressed in neoplastic gonads compared to healthy ones (p < 0.05).Similarly, testes detected with sertoli cell-only tubules as well as with sertoli cells hyperplasia showed higher expression than gonads without such alterations for ck, des, amh and plap, and for ck and des, respectively (p < 0.05).The same trend was observed in undescended respect to scrotal testes even though their positivity was significant only for des, inh and amh (p < 0.05).Immunohistochemical positivity found in scrotal testes of unilateral cryptorchid dogs, even in absence of detectable anatomical abnormalities, was suggestive of precancerous lesions.Despite the limited sample size, this study could help to clarify the predisposition to neoplastic development in normally descended testes.These markers expression in adult life could allow identifying the early stages of the testicular carcinogenesis process besides suggesting a precautionary bilateral surgical approach in unilateral cryptorchid dogs.

Journal: Theriogenology (2021)
Publication types: Journal Article