syedzayyan/paper_mill_benchmark huggingface dataset:
Slowly Progressive Limb-Girdle Weakness and HyperCKemia - Limb Girdle Muscular Dystrophy or Anti-3-Hydroxy-3-Methylglutaryl-CoA-Reductase-Myopathy?

Anti-3-hydroxy-3-methylglutaryl-co a reductase (hmgcr)-myopathy is a usually rapidly progressive form of immune-mediated necrotizing myopathy (imnm).Rarer clinical courses show slow progression and resemble the phenotype of limb-girdle dystrophy (lgmd).Objective we demonstrate the difficulties in differentiating lgmd versus anti-hmgcr-myopathy.Methods we report on a 48-year-old patient with slowly progressive tetraparesis and hyper ckemia for more than 20 years.Results due to myopathic changes in initial and second muscle biopsy and typical clinical presentation, the patient was diagnosed with lgmd 20 years ago; despite comprehensive genetic testing including exome diagnostics, the genetic cause of disease could not be identified.Finally, hmg-co a reductase antibodies were detected, confirming the diagnosis of anti-hmgcr-myopathy.By re-work-up of a second muscle biopsy specimen from year 2009, the diagnosis of a imnm was made in retrospect.Seven cycles of high-dose immunoglobulins were administered; patient reported outcome measures have mildly improved.Conclusion patients with clinical lgmd phenotype, degenerative changes in muscle biopsy but without genetic confirmation of the disease should be tested for hmg-co a-myopathy, thereby allowing for an early start of treatment.

Journal: Journal of neuromuscular diseases (2022)
Publication types: Case Reports;Journal Article
Temperature dependence of up-conversion luminescence and sensing properties of LaNbO4: Nd3+/Yb3+/Ho3+phosphor under 808 nm excitation.

La nb o4: nd3+/yb3+/ho3+phosphor was prepared by a conventional high temperature solid-state reaction method.The temperature dependence of up-conversion (uc) luminescence property of la nb o4: nd3+/yb3+/ho3+phosphor under 808 nm excitation and the potential application of exploiting the red-to-green uc emission intensity ratio (ir/ig) of ho3+in temperature sensing were studied.Two-photon processes were confirmed to be responsible for both the green and the red uc emissions at different temperatures by analyzing the excitation power density dependent uc luminescence spectra measured at different temperatures.The energy level diagram was drawn to analyze the uc luminescence mechanism of ho3+.In addition, it was found that the ratio ir/igof ho3+was independent of the excitation power density of 808 nm laser under the current experimental condition, but it was sensitive to the temperature.And the temperature dependent uc luminescence spectra displayed that the ratio ir/igexhibited a good linear increasing tendency with temperature rising.The obtained temperature sensing sensitivity was 2.04 × 10-3k-1in the temperature range of 303-693 k.The results suggest that la nb o4: nd3+/yb3+/ho3+phosphor may be a good candidate for application in optical temperature sensors.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2021)
Publication types: Journal Article
Validation and Psychometric Evaluation of the Italian Version of the Fear of COVID-19 Scale.

The advent of covid-19 worldwide has led to consequences for people's health, both physical and psychological, such as fear and anxiety.This is the case in italy, one of the countries most affected by the pandemic.Given the heightened fear concerning covid-19 in italy., the present study analyzed the psychometric properties of the italian version of the fear of covid-19 scale (fcv-19s).Methods the sample comprised 250 italian participants who were administered italian versions of the fcv-19s, the hospital anxiety and depression scale (hads), and the severity measure for specific phobia-adult (smsp-a).Several psychometric tests were performed to investigate the validity and reliability of the test including confirmatory factor analysis.Results analysis of the data showed satisfactory psychometric characteristics and confirmed the scale's unidimensional properties.The seven fcv-19s items had acceptable correlations with the test total (from .443 to .784).Furthermore, the loadings on the factor were significant and strong (from .684 to .897).The internal consistency was very good (α = .871).Construct validity for the fcv-19s was supported by significant and positive correlations with the hads (r=.649) and smsp-a (r=.703).Conclusions the italian version of the fear of covid-19 scale is valid and reliable in assessing fear of covid-19 among the general italian population.

Journal: International journal of mental health and addiction (2022)
Publication types: Case Reports;Journal Article
App-based pelvic floor muscle training in pregnant and postnatal women: A prospective cohort study exploring factors associated with prevention and improvement of urinary incontinence.

And aims pelvic floor muscle training (pfmt) is recommended for continent pregnant women and postnatal women experiencing urinary incontinence (ui).The app tät® has been developed for the treatment of stress ui with a focus on pfmt.The aim of this study was to investigate factors associated with the improvement of incontinence symptoms and retained continence in pregnant and postnatal women who used the app.Methods a prospective cohort study was carried out based on user questionnaires from the app tät®.We included pregnant and postnatal women who answered the inclusion questionnaire between june 19, 2019 and september 19, 2020.The questionnaire included questions about the frequency and amount of leakage, the impact that ui has on everyday life, and experienced improvements at follow-up.We analyzed factors associated with improvement and retained continence using logistic regression.Results we included 10,307 pregnant and 13,670 postnatal women, and 44% of the pregnant women and 52% of the postnatal women were incontinent.A total of 3680 women were included in the follow-up analysis, and 52% of the pregnant incontinent women and 73% of the postnatal incontinent women experienced improvement.Pregnant women who performed pfmt and used the app at least once per week had increased odds of improvement (odds ratio [or]: 1.83, 95% confidence interval [ci]: 1.01-3.29 and or: 3.38, 95% ci: 1.94-5.90, respectively) compared to those who performed no training and had no app usage.Postnatal women who used the app at least once per week and had more severe incontinence had increased odds of improvement (or: 4.26, 95% ci: 2.37-7.64 and or: 1.11, 95% ci: 1.05-1.16, respectively).Conclusions the app tät® is widely used by pregnant and postnatal women in sweden for the prevention and treatment of ui.Majority of the women with incontinence experienced improvement after using the app.Regular pfmt and app use seemed to be important factors for experiencing improvement.

Journal: Health science reports (2022)
Publication types: Journal Article
Seasonal Activity of Urban Bats Populations in Temperate Climate Zone-A Case Study from Southern Poland.

Municipal greenery can mitigate the negative impact of urbanization on biodiversity, including bats, by providing a migration corridor, food base and roosts.Our study aimed to evaluate the species composition and diversity, test the differences in activity between seasons, and identify the atmospheric conditions influencing the bats' activity in the planty park (cracow).Fieldworks were conducted in 2016 and 2017.We recorded 10 species, two new for this part of poland: the kuhl's pipistrelle (pipistrellus kuhlii) and the savi's pipistrelle (hypsugo savii).Taxa were divided into three ecological guilds.myotisgroup's activity was insufficient to perform statistical analyses.The activity of nyctalus,eptesicusand vespertiliogroup peaked in late summer.A similar insignificant trend was observed for pipistrellusand hypsugo.Temperature enhanced the activity of nyctalus,eptesicusand vespertiliogroup in spring and early summer, while cloud cover suppressed their activity in autumn.Temperature also enhanced pipistrellusand hypsugogroup activity in spring and autumn, but it suppressed their summer activity.Our study is one of the first to investigate temperate urban bats' phenology and may serve as a preface for further research to introduce detailed urban landscape planning recommendations.

Journal: Animals : an open access journal from MDPI (2021)
Publication types: Journal Article
An examination of the role of social comparison orientation and social norms in drunkorexia engagement.

Drunkorexia is a behavior pattern marked by calorie restriction and/or compensation in relation to alcohol consumption.The aim of the present study was to examine the role of social norms (descriptive, injunctive) and social comparison orientation (sco; global, alcohol-specific, eating disorder-related) in drunkorexia engagement.Specifically, our research aimed to examine a possible interaction between norms and sco; we hypothesized that the relationship between social norms and drunkorexia would be moderated by sco in that the relationship would be stronger among those elevated on sco.Data were collected from an undergraduate sample (n = 501); participants completed the consent form and questions/questionnaires via qualtrics.The results indicated that the predictor variables examined were correlated with overall drunkorexia engagement.In the regression models, in terms of main effects, eating disorder-related sco emerged as the strongest predictor of the drunkorexia dimensions as well as overall drunkorexia engagement.Descriptive norms emerged as the second strongest predictor in the models.Only one interaction was identified; eating disorder-related sco moderated the relationship between descriptive norms and the bulimia drunkorexia dimension.The simple slopes analysis indicated that descriptive norms was positively predictive of the bulimia drunkorexia dimension only among individuals with average or elevated eating disorder-related sco.Social comparisons made regarding one's body, eating, or exercise (eating disorder-related) and social norms are potentially important targets for drunkorexia prevention and/or intervention programs.Further research is needed to better understand risk factors for drunkorexia engagement in the college population.

Journal: Addictive behaviors (2022)
Publication types: Journal Article
Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial.

This randomized placebo-controlled clinical trial evaluated the effect of bifidobacterium animalis subsp.Lactis (b.Lactis) hn019-containing probiotic lozenges as adjuvant to scaling and root planing (srp) in patients with generalized chronic periodontitis.Materials and methods forty-one chronic periodontitis patients were recruited and monitored clinically, immunologically, and microbiologically at baseline (before srp) and 30 and 90 days after srp.All patients were randomly assigned to a test (srp + probiotic, n = 20) or control (srp + placebo, n = 21) group.The probiotic lozenges were used twice a day for 30 days.The data were statistically analysed.Results the test group presented a decrease in probing pocket depth and a clinical attachment gain significantly higher than those of the control group at 90 days.The test group also demonstrated significantly fewer periodontal pathogens of red and orange complexes, as well as lower proinflammatory cytokine levels when compared to the control group.Only the test group showed an increase in the number of b.Lactis hn019 dna copies on subgingival biofilm at 30 and 90 days.Conclusion the use of b.Lactis hn019 as an adjunct to srp promotes additional clinical, microbiological, and immunological benefits in the treatment of chronic periodontitis (nct03408548).

Journal: Journal of clinical periodontology (2018)
Publication types: Journal Article;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
Epidermal Growth Factor Pathway in the Age-Related Decline of Oligodendrocyte Regeneration.

Oligodendrocytes (ols) are specialized glial cells that myelinate cns axons.Ols are generated throughout life from oligodendrocyte progenitor cells (opcs)viaa series of tightly controlled differentiation steps.Life-long myelination is essential for learning and to replace myelin lost in age-related pathologies such as alzheimer's disease (ad) as well as white matter pathologies such as multiple sclerosis (ms).Notably, there is considerable myelin loss in the aging brain, which is accelerated in ad and underpins the failure of remyelination in secondary progressive ms.An important factor in age-related myelin loss is a marked decrease in the regenerative capacity of opcs.In this review, we will contextualize recent advances in the key role of epidermal growth factor (egf) signaling in regulating multiple biological pathways in oligodendroglia that are dysregulated in aging.

Journal: Frontiers in cellular neuroscience (2022)
Publication types: Journal Article;Review
The complexity of ventral CA1 and its multiple functionalities.

The hippocampus is one of the most widely investigated brain regions with its massive contributions to multiple behaviours.Especially, the hippocampus is subdivided into the dorsal and ventral parts playing distinct roles.In this review, we will focus on the ventral hippocampus, especially the ventral ca1 (v ca1), whose role is being actively discovered.V ca1 is well known to be associated with emotion-like behaviour, in both positive (reward) and negative (aversive) stimuli.How can this small region in volume mediate such variety of responses?This question will be answered with technologies up to date that have allowed us to study in-depth the specific neural circuit and to map the complex connectivity.

Journal: Genes, brain, and behavior (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't
The prognostic value of the CHA2DS2-VASc score in coronary collateral circulation and long-term mortality in coronary artery disease.

The cha2ds2-vasc score is used to determine thromboembolic risk in cases of atrial fibrillation.The predictive value of this score in predicting coronary collateral circulation in chronic total occlusion is unknown.Objective the aim of this study was to investigate the relationship between the cha2ds2-vasc score and coronary collateral circulation in patients with chronic total occlusion.Methods a total of 189 patients, who underwent coronary angiography and had a chronic total occlusion in at least one coronary artery, were enrolled in this study.The rentrop scoring system was used for grouping the patients, and patients were classified as having poorly developed coronary collateral circulation (rentrop grade 0 or 1) or well-developed coronary collateral circulation (rentrop grade 2 or 3).Results the cha2ds2-vasc score of the good coronary collateral circulation group was significantly lower than the other group (3.1±1.7 vs.3.7±1.7, p=0.021).During the follow-up period, 30 (32.2%) patients in the poorly developed coronary collateral circulation group and 16 (16.7%) patients in the well-developed coronary collateral circulation group died (p=0.028).According to the multivariable cox regression model, the cha2ds2-vasc score [hazard ratio (hr): 1.262, p=0.009], heart rate (hr: 1.049, p=0.003), lvef (hr: 0.975, p=0.039), mean platelet volume (hr: 1.414, p=0.028), and not taking acetylsalicylic acid during admission (hr: 0.514, p=0.042) were independently associated with a higher risk of mortality.Conclusions the cha2ds2-vasc score is closely related to coronary collateral development and predicts mortality in patients with chronic total occlusion.

Journal: Revista da Associacao Medica Brasileira (1992) (2022)
Publication types: Journal Article
Multi-center evaluation of dose conformity in stereotactic body radiotherapy.

And purpose stereotactic body radiotherapy (sbrt) is an emerging technique for treating oligometastases, but limited data is available on what plan quality is achievable for a range of modalities and clinical sites.Methods sbrt plans for lung, spine, bone, adrenal, liver and node sites from 17 participating centers were reviewed.Centers used various delivery techniques including static and rotational intensity-modulation and multiple non-coplanar beams.Plans were split into lung and other body sites and evaluated with different plan quality metrics, including two which are independent of target coverage; "prescription dose spillage" (pds) and "modified gradient index" (mgi).These were compared to constraints from the rosel and rtog 0813 clinical trials.Results planning target volume (ptv) coverage was compromised (ptv v100% < 90%) in 29% of patient plans in order to meet organ-at-risk (oar) tolerances, supporting the use of plan quality metrics which are independent of target coverage.Both lung (n = 48) and other body (n = 99) site pds values agreed well with rosel constraints on dose spillage, but rtog 0813 values were too high to detect sub-optimal plans.Mgi values for lung plans were mis-matched to both sets of previous constraints, with rosel values too high and rtog 0813 values too low.Mgi values were lower for other body plans as expected, though this was only statistically significant for ptv volumes <20 cm3.Conclusions updated guidance for lung and other body site sbrt plan quality using the pds and mgi metrics is presented.

Journal: Physics and imaging in radiation oncology (2019)
Publication types: Journal Article
Synthesis and characterization of nano starch-based composite films from kidney bean (Phaseolus vulgaris).

This study was aimed to synthesize and evaluate the nano starch-based composite films by the addition of nano starch in film formulation at 0.5, 1, 2, 5 and 10% level of total starch.The acid hydrolysis technique was used to reduce the size of starch granules of kidney bean starch.The physicochemical properties of both native and nano starch were determined.Nano starch showed a higher value for swelling power, solubility, water and oil absorption capacity when compared with native starch.The particle size of kidney bean nano starch was 257.7 nm at 100% intensity.The size of starch granule affects various properties of films.The thickness, solubility and burst strength of the composite films were increased significantly (p≤ 0.05) with an increase in the concentration of nano starch in film formulation.While the moisture content and water vapour transmission rate (wvtr) were decreased significantly (p≤ 0.05) with an increase in the concentration of nano starch in film formulation.The results suggested that kidney bean starch could be used for the development of packaging films.The utilization of nano starch in film formulations had an additional advantage in improving the film properties.

Journal: Journal of food science and technology (2021)
Publication types: Journal Article
Role of TRPV1 ion channel in cervical squamous cell carcinoma genesis.

The transient receptor potential (trp) family is a widely expressed superfamily of ion channels that regulate intracellular ca2+homeostasis and signal transduction.Abnormal expression of trpv1 is closely related to malignant tumors of the female reproductive system such as breast, ovarian, cervical and endometrial cancers.In this study, we found a significant reduction of trpv1 expression in cervical squamous cell carcinoma and this expression is inversely association with the risk of cervical squamous cell carcinoma.Furthermore, trpv1 is involved in cell differentiation, iron death, inflammatory response, and metabolic regulation in cervical squamous cell carcinoma.Meanwhile trpv1 is positively correlated with t cells and negatively associated with macrophages, indicating that trpv is associated with tumor cell immunity.Therefore, trpv1 may be a potential marker of cervical cancer and a promising anti-cancer drug candidate.

Journal: Frontiers in molecular biosciences (2022)
Publication types: Journal Article
Comparison of Pediatric Sequential Organ Failure Assessment and Pediatric Risk of Mortality III Score as Mortality Prediction in Pediatric Intensive Care Unit.

To assess and compare the diagnostic accuracy of the pediatric risk of mortality (prism) iii score and pediatric sequential organ failure assessment (p-sofa) for the prediction of mortality in critically ill children.Methodology this was a cross-validation study conducted at the pediatric intensive care unit (picu) of the national institute of child health karachi from february 2021 to july 2021.Two hundred eighty-six critically ill children of age one month to 15 years of either gender staying in picu for more than 24 hours were included.Within 24 hours of admission, the p-sofa and prism iii 24 scores were calculated for all eligible children.The outcome of the study was mortality within 30 days of picu admitted children.Data were analyzed using statistical package for the social sciences (spss) version 23.Results the median age was 24 months (range: 1-144 months).The 30-day mortality was estimated as 57%.The p-sofa and prism scores were significantly greater in children who did not survive than survivors.The maximum p-sofa score (area under the curve (auc)=0.81, 95% ci=0.76-0.86, p=0.001) and prism iii 24 score (auc=0.75, 95% ci=0.69-0.81, p=0.001) had good discrimination for 30-day mortality.For the prediction of 30-day mortality at the cut-off value of p-sofa>2, the sensitivity was 93.87%, specificity was 38.21%, and accuracy was 69.93%.Whereas at the cut-off value of prism iii 24 score>8, the sensitivity was 55.83%, specificity was 77.24%, and accuracy was 65.03%.Conclusion the p-sofa score is a good predictor for 30-day mortality in critically ill children and had better accuracy than the prism iii 24 score.

Journal: Cureus (2022)
Publication types: Journal Article
RNA metabarcoding helps reveal zooplankton community response to environmental stressors.

Dna metabarcoding can provide a high-throughput and rapid method for characterizing responses of communities to environmental stressors.However, within bulk samples, dna metabarcoding hardly distinguishes live from the dead organisms.Here, both dna and rna metabarcoding were applied and compared in experimental freshwater mesocosms conducted for assessment of ecotoxicological responses of zooplankton communities to remediation treatment until 38 days post oil-spill.Furthermore, a novel indicator of normalized vitality (nv), sequence counts of rna metabarcoding normalized by that of dna metabarcoding, was developed for assessment of ecological responses.Dna and rna metabarcoding detected similar taxa richness and rank of relative abundances.Both dna and rna metabarcoding demonstrated slight shifts in measured α-diversities in response to treatments.Nv presented relatively greater magnitudes of differential responses of community compositions to treatments compared to dna or rna metabarcoding.Nv declined from the start of the experiment (3 days pre-spill) to the end (38 days post-spill).Nv also differed between rotifer and arthropoda, possibly due to differential life histories and sizes of organisms.Nv could be a useful indicator for characterizing ecological responses to anthropogenic influence; however, the biology of target organisms and subsequent rna production need to be considered.

Journal: Environmental pollution (Barking, Essex : 1987) (2022)
Publication types: Journal Article