syedzayyan/paper_mill_benchmark huggingface dataset:
The systemic inflammatory response syndrome in acute antipsychotic poisoning

The purpose of this study was to investigate the mutual effect of systemic inflammatory response syndrome (sirs) accompanied with fibrinolysis, endotoxemia, and coagulation in severe cases of antipsychotic poisoning.A total of 199 patients were examined, of which 71 were men and 128 were women.The age of the patients was from 22 to 63 years, (45.3 ± 6.1 years on average).According to the results of the course of therapy, the patients were divided into two groups.In the blood plasma, the content of c‐reactive protein, fibrinogen and its proteolysis products (oligopeptides, d‐dimers), interleukin‐6 were determined.In the first 1 to 3 days, in group 1, the level of interleukin‐6 decreased and approached the normal level ( p ≤ .05).The opposite trend continued throughout the observation of patients from group 2—their levels of interleukin‐6 increased day by day ( p ≤ .05).The concentration of d‐dimer already in 1 day after admission to intensive care in patients from group 2 exceeded the norm by 14 times ( p ≤ .05).The level of d‐dimer correlated with the level of oligopeptides in blood plasma upon admission, as well as for 3 and 5 days after admission to intensive care: 0.36, 0.76 at p ≤ .05, 0.94 at p ≤ .01, respectively.Similar correlations were obtained for the content of oligopeptides in urine and the level of d‐dimer: 0.55, 0.85 at p ≤ .05, 0.93 at p ≤ .01.In this regard, the most pronounced correlation is that between the sirs score, plasma d‐dimer level, and the plasma level of the d‐dimer derivatives, oligopeptides.

Journal: Journal of Biochemical and Molecular Toxicology (2020)
Publication types: Clinical Study;
Histone methyltransferase SUV39H2 regulates LSD1-dependent CDH1 expression and promotes epithelial mesenchymal transition of osteosarcoma

Objective osteosarcoma (os) is a malignant tumor characterized by the direct production of bone or osteoid tissues by proliferating tumor cells.Suppressor of variegation 3–9 homolog 2 (suv39h2) is implicated in the occurrence of os.Therefore, we designed this study to investigate effects of suv39h2 in os meditated by the lysine specific demethylase-1/e-cadherin (lsd1/cdh1) axis.Methods clinical os tissues and paracancerous tissues were collected for analysis of suv39h2, lsd1 and cdh1 expression, and kaplan–meier survival analysis was applied to test the relationship between suv39h2 expression and overall survival.Loss- and gain-of-function assays were conducted to determine the roles of suv39h2, lsd1 and cdh1 in os epithelial mesenchymal transition (emt) and migration in os cells, with quantitation of relevant proteins by immunofluorescence.We confirmed the effects of modulating the suv39h2/cdh1 axis in a mouse os tumor model.Results suv39h2 and lsd1 were highly expressed, while cdh1 was downregulated in os tissues and cells.Suv39h2 expression correlated inversely with overall survival of patients with os.Suv39h2 positively regulated lsd1 expression, while lsd1 negatively regulated cdh1 expression.Suv39h2 or lsd1 overexpression, or cdh1 silencing promoted migration and emt, as indicated by reduced e-cadherin and dramatically upregulated vimentin and n-cadherin of os cells.Suv39h2 expedited the progression of os, which was reversed by cdh1 repression in the setting of os in vitro and in vivo.Conclusions collectively, our results demonstrate highly expressed suv39h2 in os elevates the expression of lsd1 to downregulate cdh1 expression, thereby aggravating os, providing a potential therapeutic target for treatment of os.

Journal: Cancer Cell International (2021)
Publication types: Research Article;
MicroRNA-25 suppresses proliferation, migration, and invasion of osteosarcoma by targeting SOX4

Altered expression of the mi r-25 has been implicated in many human malignant progression as oncogene or tumor suppressor.However, the precise role of mi r-25 in osteosarcoma progression remains largely unclear.This study aimed to investigate the role and underlying mechanism of mi r-25 in osteosarcoma.In this study, we demonstrated that mi r-25 was significantly downregulated in osteosarcoma cell lines and tissues and that lower mi r-25 was associated with advanced tumor–node–metastasis stage and lymph node metastasis.Then, we found that introduction of mi r-25 significantly suppressed the proliferation, colony formation, migration, and invasion of osteosarcoma cells in vitro and retarded tumor growth in vivo.Further studies indicated that the epithelial–mesenchymal transition–related transcription factor, sox4 (sry-related high-mobility group box 4), was a direct target gene of mi r-25, evidenced by bioinformatics analysis predicted and luciferase reporter assay.Furthermore, mi r-25 could decrease the expression of sox4 levels and inhibited epithelial–mesenchymal transition process.The levels of mi r-25 were inversely correlated with those of sox4 expression in osteosarcoma tissues.Sox4 overexpression rescued mi r-25-induced suppression of proliferation, migration, and invasion of osteosarcoma cells.Taken together, these results suggest that mi r-25 functions as a tumor suppressor in the progression of osteosarcoma by repressing sox4.

Journal: Tumor Biology (Tumour Biology) - Official Journal of the International Society of Oncology and BioMarkers (ISOBM) (2017)
Publication types: Research Article;
LncRNA SNHG7 promotes pancreatic cancer proliferation through ID4 by sponging miR-342-3p

Background small nucleolar rna host gene 7 (snhg7) is a novel identified oncogenic gene in tumorigenesis.However, the role that snhg7 plays in pancreatic cancer (pc) remains unclear.In this study, we aimed to investigate the functional effects of snhg7 on pc and the possible mechanism.Methods the expression levels of snhg7 in tissues and cell lines were measured by rt-q pcr.Cell viability, apoptosis, migration and invasion were examined to explore the function of snhg7 on pc.Bioinformatics methods were used to predict the target genes.The mechanism was further investigated by transfection with specific si-rna, mi rna mimics or mi rna inhibitor.Tumor xenograft was carried out to verify the effects of snhg7 in vivo.Results we found that snhg7 was overexpressed in both pc tissues and cell lines.High expression level of snhg7 was correlated with the poor prognosis.Snhg7 knockdown inhibited the proliferation, migration and invasion of pc cells.Moreover, snhg7 was found to regulate the expression of id4 via sponging mi r-342-3p.Additionally, this finding was supported by in vivo experiments.Conclusions lnc rna snhg7 was overexpressed in pc tissues, and knockdown of snhg7 suppressed pc cell proliferation, migration and invasion via mi r-342-3p/id4 axis.The results indicated that snhg7 as a potential target for clinical treatment of pc.

Journal: Cell & Bioscience (2019)
Publication types: Research Article;
Efficacy of Balloon Guide Catheter-Assisted Thrombus Repair in Stroke Treatment: A Retrospective Survey in China

The first‐pass (fp) effect, defined by successful cerebral reperfusion from a single pass of an endovascular stentriever, was associated with shorter procedural times and possible improved outcomes in patients with ischemic stroke secondary to large vessel occlusion.The adjunctive use of balloon guide catheter (bgc) may increase the rates of the first‐pass effect.In this retrospective study we examined the impact of bgc on the first‐pass effect in acute stroke patients.Methods .We included patients with acute ischemic stroke with large vessel occlusion treated by endovascular thrombectomy from 2018 to 2019.We categorized the cases into bgc and non‐bgc groups.Differences in time metrics and outcomes were compared.Result .One hundred and thirty‐two patients were included, and sixty‐two were in bgc group (47.0%).The median procedural time was shorter (83.0 minutes vs 120.0 minutes, p = 0.000), and fp rate was higher in bgc group (58.1% vs 32.9%, p = 0.004) compared with non‐bgc group.Proportion of modified thrombolysis in cerebral infarction (m mtici) 3 was higher (66.1% vs 37.1%, p = 0.001), and modified rankin scale (m rs) 0 to 2 was higher (59.7% vs 41.4%, p = 0.036) in bgc group compared with non‐bgc group.In addition, bgc was associated with successful reperfusion odds ratio, 0.383; 95% confidence interval: 0.174‐0.847; p = 0.018).The fp rate of bgc in the distal ica was higher than that in the proximal ica (87.5% vs 39.5%, p = 0.000), and the good clinical outcome rate at 90 days in the distal ica was also higher than that in the proximal ica (91.7% vs 39.5%, p = 0.000).Conclusion .We showed that bgc shortened the procedural time and increased the rate of the successful fp.We recommend that bgc could be considered the preferred technique for endovascular intervention in stroke.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Effect of Family Participatory Nursing Model Based on WeChat Platform on Psychological Elasticity and Quality of Life of Patients with Lung Cancer

To explore the effect of family participatory nursing model based on we chat platform on psychological elasticity and life quality of patients with lung cancer.Methods.One hundred patients with lung cancer treated in our hospital from february 2019 to april 2021 were enrolled.The patients were randomly assigned into control group and study group.The control group received routine nursing and the study group received family participatory nursing model based on we chat platform.The scores of nursing satisfaction, self‐feeling burden, symptom group assessment scale, family care index, and compliance and life quality were compared.Results .First of all, we compared the nursing satisfaction: the study group was very satisfied in 25 cases, satisfactory in 20 cases, general in 5 cases, the satisfaction rate was 100.00%; the control group was very satisfied in 14 cases, satisfactory in 17 cases, general in 13 cases, dissatisfied in 6 cases, and the satisfaction rate was 88.00%.Compared between the two groups, the nursing satisfaction in the study group was higher compared to the control group ( p &lt; 0.05).Secondly, we compared the self‐perceived burden, the emotional burden, physical burden, and economic burden and total scores of the study group were lower compared to the control group ( p &lt; 0.05).Comparing the scores of symptom group evaluation scale, the scores of respiratory symptoms, fatigue symptoms, psychological and emotional symptoms, digestive tract symptoms, and nervous system symptoms in the study group were lower compared to the control group ( p &lt; 0.05).In terms of the family care index of the two groups, the scores of fitness, cooperation, length, emotion, and intimacy in the study group were higher compared to the control group ( p &lt; 0.05).Comparison of compliance, the study group was very compliant in 42 cases, compliant in 7 cases, noncompliant in 1 case, the compliance rate was 98.00%; the control group was very compliant in 24 cases, compliant in 20 cases, noncompliant in 6 cases, the compliance rate was 88.00%.The compliance rate in the study group was higher compared to the control group ( p &lt; 0.05).Finally, we compared the scores of qualities of life.Before nursing, there exhibited no significant difference ( p &gt; 0.05).The scores of physiological function, psychological function, social function, and health self‐cognition in the study group were lower compared to the control group ( p &lt; 0.05).Conclusion.The family participatory nursing model based on we chat platform helps to facilitate the psychological elasticity and quality of life of patients with lung cancer and further promote patients’ self‐care ability and compliance with lung cancer.It can also effectively enhance family care and nursing satisfaction; the nursing model is worth popularizing and applying in clinic.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Effects of Vibration Training on Weight Loss and Heart Rate Variability in the Obese Female College Students

The present study examined the effects of a 12‐week whole‐body vibration training (wbvt) regimen on heart rate variability (hrv) and body composition in the obese female college students.Methods.Participants were assigned to either the wbvt ( n = 17) or obese control group ( n = 19).The students in the wbvt group conducted a 12‐week (5 times per week and 30 min per time) exercise protocols (30 to 40 hz of frequency and 4 mm of amplitude), and the obese control group did not perform regular physical training during 12 weeks of study.Then, body composition (body weight, bmi, body fat, body fat percentage; trunk fat mass, muscle mass, mm) and hrv (time domain and frequency domain index) were measured in all subjects before and after wbvt intervention.Results .(1) after 12‐week wbvt intervention, body fat mass, trunk fat mass, and body fat percentage significantly decreased and muscle mass increased in the wbvt group ( p &lt; 0.01, respectively); there was no significant change in body weight and bmi ( p &gt; 0.05, respectively).(2) after 12‐week wbvt intervention, lfn, lf/hf, and hr significantly decreased ( p &lt; 0.05, p &lt; 0.01), r‐r interval and rmssd significantly increased ( p &lt; 0.01, respectively), and there was no significant difference in hfn ( p &gt; 0.05).Nevertheless, there was no significant change before and after the test in body composition and hrv in the obese control group ( p &gt; 0.05, respectively).(3) after 12‐week wbvt intervention, compared with the obese control group, body fat mass, body fat percentage, trunk fat mass, and lf/hf significantly decreased ( p &lt; 0.05, p &lt; 0.01), muscle mass, and rmssd increased ( p &lt; 0.05) in the wbvt group; but there were no significant difference in other indicators ( p &gt; 0.05) between the obese control group and wbvt group.(4) the reduction of body fat percentage before and after the wbvt intervention are positively correlated with the reduction in the lfn and lf/hf ( r = 0.542, r = 0.504; p &lt; 0.05, respectively) and negatively correlated with the increase in the rmssd ( r = −0.514, p &lt; 0.05), and the reduction of trunk fat mass are positively correlated with the reduction in the lf/hf ( r = 0.540, p &lt; 0.05).Conclusion.The results indicate that wbvt improves hrv and body composition in obese female college students, and the reduction in body fat percentage and trunk fat mass are associated with a shift in cardiac autonomic regulation towards vagal dominance and improve sympathetic‐vagus balance after wbvt intervention.In conclusion, wbvt may be a feasible treatment to improve cardiac autonomic function and body composition.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Exploration on the Effect of Nonselective β-Receptor Blockers (NSBBs) on Hemodynamic Parameters in Complicated Liver Cirrhosis

Esophageal‐gastric variceal bleeding occurs in 5–15% of patients with liver cirrhosis annually, and the mortality rate is as high as 20% within 6 weeks of the first bleed.The more compromised the liver function, the higher the mortality.Effective control of bleeding is pivotal for reducing mortality in patients with liver cirrhosis.To explore the effect of nonselective β ‐receptor blockers (nsbbs) on hemodynamic parameters in liver cirrhosis complicated with esophageal‐gastric variceal bleeding and the association with hepatorenal syndrome (hrs), this retrospective study assessed the clinical data of 248 patients with liver cirrhosis and esophageal‐gastric variceal hemorrhage admitted to our hospital for research.112 patients are treated with somatostatin (control group) and 136 with somatostatin+propranolol (study group).The success rate of hemostasis, changes of hemodynamic parameters before and after treatment, and incidence of hrs are compared between the groups.Logistic regression analysis is used to explore the use of propranolol when hrs occurred.Nsbbs combined with somatostatin are more effective than somatostatin alone in the treatment of liver cirrhosis complicated with esophageal‐gastric variceal bleeding; nsbbs may be associated with the occurrence of hrs.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Big Data Analysis of Manufacturing and Preclinical Studies of Nanodrug-Targeted Delivery Systems: A Literature Review

Nanodelivery is a modern technology involving improved delivery methods and drug formulations.The current development and initial applications of nanocarriers are pointing to new directions in the current development of nanomedicine.Researchers are increasingly applying nanodelivery to the delivery of therapeutic or diagnostic agents.This article discusses the preparation and application of nanocomplexes and nanoparticles, as well as their potential future value in clinical research.Through a review and analysis, it is hoped that this will serve as a guide for the future development of various nanodelivery technologies and help researchers learn more about these technologies.Materials and methods .A literature search was conducted using the keywords “nano drug delivery” or “nanomedical materials” or “nano”.A literature search was conducted in three major databases, pub med, web of science, and google scholar, using the keywords such as “nano drug delivery”, “nanomedical materials”, or “nanobubble drug delivery”.The initial search was screened by title and abstract.In the full‐text review, the titles or abstracts were reviewed according to the selection criteria based on the inclusion criteria.The risk of bias and study quality was assessed according to the cochrane guidelines, and possible biases such as selection bias and good selection bias were included in the review.Results .A total of 297 studies were included in this study, of which 219 were excluded based on the screening criteria, resulting in the inclusion of 78 studies, the majority of which were original studies and clinical trials, and a small number of which provided design and route of administration analysis of nanomaterial particles and effect fluorograms and were studied in more depth.This paper summarises and reviews the views and directions of the included articles.The main directions include cyclodextrin‐based or grafted cyclodextrin nanomaterials, nanobubbles, and stimuli‐sensitive and temperature‐sensitive nanodelivery systems.Conclusion .The use of innovative, targeted drug delivery systems is effective in cancer drug delivery by summarising the previous studies.However, nanodelivery systems’ risks and therapeutic effects need to be evaluated before clinical application.Future research in the field of targeted drug delivery nanosystems should focus on the development of nanocarriers with high in vivo delivery capacity, good synergy with therapeutic agents, and milder short‐term and long‐term toxicological effects and conduct comprehensive preclinical trials on nanodrug delivery systems with high potential for clinical application as soon as possible, to find nanodrug delivery systems suitable for clinical use and put them into the clinical application as soon as possible.

Journal: BioMed Research International (2022)
Publication types: Review Article;
Comparison of a Small Dose of Oxycodone and Sufentanil for the Prevention of Sufentanil-Induced Cough during General Anesthesia Induction: A Prospective Randomized Controlled Trial

Sufentanil is widely used during anesthesia induction.However, it can cause coughing via different mechanisms.This study is aimed at evaluating the effectiveness of a small dose of oxycodone and sufentanil in suppressing sufentanil-induced cough (sic) during general anesthesia induction.Methods.Of the 174 patients scheduled for elective surgery, 144 were eligible and randomly divided into 3 groups ( n = 48 ).Five minutes before sufentanil bolus (0.4 μg/kg), patients in group o received 0.02 mg/kg oxycodone intravenously within 5 s, those in group s received 0.02 μg/kg sufentanil within 5 s, and those in group n received an equal volume of 0.9% normal saline within 5 s.Sufentanil was diluted to 5 μg/ml and administered within 5 s after pretreatment.The incidence and severity of cough in the three groups were evaluated within 1 minute after sufentanil injection during the anesthesia induction.Their mean arterial pressure (map) and heart rate (hr) were recorded at t0 (after entering the operation), t1 (3 minutes after pretreatment), t2 (before intubation), and t3 (1 minute after intubation).Results.The incidences of cough in group n, group o, and group s were 20 (41.6%), 7 (14.5%), and 6 (12.5%), respectively.Compared with group n, patients from group o and group s exhibited significantly reduced incidence and severity of cough, and the severity of cough in group o and group s was significantly reduced compared with group n ( p &lt; 0.05 ).No significant differences in the rangeability of map and hr were noted at the four time points in the three groups ( p &gt; 0.05 ).Conclusion.Preconditioning using intravenous oxycodone (0.02 mg/kg) or sufentanil (0.02 μg/kg) could represent an effective approach to reducing sic in anesthesia induction and was associated with relatively stable hemodynamic state during general anesthesia.This trial is registered at chinese clinical trial registry with registration number chi ctr1900021087.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
MAGE-C2/CT10 promotes growth and metastasis through upregulating c-Myc expression in prostate cancer

Prostate cancer (pc) is the most common reproductive cancer in men and the third leading cause of cancer death among men worldwide.Recently targeted therapy showed a significant therapeutic effect on pc, whereas finding more pc therapeutic target is still urgently needed.Melanoma-associated antigen-encoding c2 (mage-c2/ct10), which have significant homology with the mage-c1/ct-7 gene, was known to be involved in the development of a variety of tumors.However, the role and mechanism of mage-c2/ct10 in prostate cancer remains unclear.Herein, we found the high levels of mage-c2/ct10 in highly metastatic prostate cancer.Our findings confirmed that the depletion of mage-c2/ct10 suppressed the growth of pc cells, and restrained pc cell migration and invasion in vitro.We noticed mage-c2/ct10 could stimulate c-myc expression via fbp1, and further contributed to pc cell proliferation and motility.Performing in vivo assays, we demonstrated mage-c2/ct10 promoted tumor growth and metastasis of pc cells in mice.Collectively, we found the abnormal expression of mage-c2/ct10 in pc, and revealed the regulatory mechanism underlying mage-c2/ct10 promoting pc progression and metastasis.

Journal: Molecular and Cellular Biochemistry (2020)
Publication types: Research Article;
pH responsive polymer micelles enhances inhibitory efficacy on metastasis of murine breast cancer cells

A p h sensitive micellar cargo was fabricated for p h triggered delivery of hydrophobic drug paclitaxel with p h controlled drug release profiles.The size, drug loading content, and encapsulation efficiency of ptx loaded micelles were 20–30 nm, 7.5%, 82.5%, respectively.Ptx loaded pela-pbae micelles could enhance the intracellular uptake of a model drug significantly, with increased cytotoxicity and inhibition of tumor metastasis on 4t1 cells, as confirmed by wound healing assay and tumor cells invasion assay.The expression of metastasis and apoptosis correlated proteins on 4t1 cells decreased remarkably after intervention by ptx loaded polymer micelles, as demonstrated by western blotting and quantitative reverse transcriptional-polymerase chain reaction (q rt-pcr).Our results demonstrated the p h responsive polymer micelles might have the potential to be used in the treatment of metastatic breast tumors.

Journal: Frontiers in Pharmacology (2018)
Publication types: Research Article;