syedzayyan/paper_mill_benchmark huggingface dataset:
A case study of food handler hand hygiene compliance in high-care and high-risk food manufacturing environments using covert-observation.

Observation of behaviour is superior to cognitive data, which does not equate to behaviour.Covert-observation is seldom used in food manufacturing to assess behaviour.In this case study, closed-circuit-television footage (15 h) in a business were reviewed to assess hand hygiene compliance using an electronic-checklist.Hand hygiene attempts were observed prior to entering high-risk (cake/pie)(n= 47) and high-care (sandwich/salad)(n= 153) production areas.Business hand hygiene protocol required handwashing durations ≥ 20 s.Observed durations ranged 1-71 s, 98% of observed attempts before entering production areas did not comply with the protocol.Observed non-compliant practices may have implications for food safety in manufacturing.

Journal: International journal of environmental health research (2022)
Publication types: Journal Article
Concentrated Growth Factors Extracted from Blood Plasma Used to Repair Nasal Septal Mucosal Defect After Rhinoplasty.

To assess preliminarily the effect of concentrated growth factor (cgf) for repair of nasal septal mucosal defect after rhinoplasty.Methods ten women with mucosal defects of the nasal septum were enrolled from may 2017 to may 2018.Liquid and gel cgf was prepared from each patient's blood sample using a medifuge system, including benchtop centrifuge.After debridement of the defect, the prepared liquid cgf was injected around the wound, and a membranous cgf film was applied to the surface.Vaseline gauze was used to pack the nostrils.All patients were treated with cgf at intervals from 3 to 5 days.Results after 3 to 12 treatments, all the patients achieved successful repair of the nasal septal mucosal defect, with good appearance and function.During a follow-up of 3 to 6 months, no recurrence was observed.Conclusion cgf appeared to have great curative effect for patients with nasal septal mucosal defects after rhinoplasty.The procedure was easy to perform and should be considered worthwhile in clinical practice.Level of evidence iv this journal requires that authors assign a level of evidence to each article.For a full description of these evidence-based medicine ratings, please refer to the table of contents or the online instructions to authors www.springer.com/00266.

Journal: Aesthetic plastic surgery (2020)
Publication types: Journal Article
Effects of Aging on Metabolic Characteristics of Human B Cells.

Metabolic changes represent the most common sign of aging and lead to increased risk of developing diseases typical of old age.Age-associated metabolic changes, such as decreased insulin sensitivity, decreased mitochondrial function, and dysregulated nutrient uptake, fuel the low-grade chronic systemic inflammation, known as inflammaging, a leading cause of morbidity and mortality, linked to the development of several diseases of old age.How aging affects the metabolic phenotype of immune cells, and b cells in particular, is not well known and is under intensive investigation by several groups.In this study, we summarized the few published results linking intrinsic b-cell metabolism and b-cell function in different groups of young and elderly individuals: healthy, with type-2 diabetes mellitus, or with hiv infection.Although preliminary, these results suggest the intriguing possibility that metabolic pathways can represent potential novel therapeutic targets to reduce inflammaging and improve humoral immunity.

Journal: Journal of acquired immune deficiency syndromes (1999) (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Bacillamide F, Extracted from MarineBacillus atrophaeusC89, Preliminary Effects on Leukemia Cell Lines.

Developing new treatments for leukemia is essential since current therapies often suffer from drug resistance and toxicity.Bacillamides are very promising, naturally occurring compounds with various bioactivities.In the present study, we investigated the use of bacillamide analogues, a new thiazole alkaloid bacillamide f that was isolated from marine bacillus atrophaeus c89 associated with sponge dysidea avara.The structure of the new compound bacillamide f with indolyl−thiazolyl−pyrrolidine ring was determined by high resolution mass spectrometry, secondary mass spectrometry, and nuclear magnetic resonance analyses.Intriguingly, bacillamide f is able to inhibit the proliferation of an acute myeloid leukemia cell line hl60 (ic50 (24 h) 21.82 μm), and an acute t-cell leukemia jurkat (ic50 (24 h) 46.90 μm), rather than inhibit the proliferation of the acute histiocytic lymphoma u-937 cell line, human fetal lung fibroblast mrc-5 cell line, and some solid tumor cell lines (ic50 (24 h) > 100 μm).The study provides a new indication of the pharmacological activity of natural product bacillamides.

Journal: Biology (2022)
Publication types: Journal Article
Multiple QTL Mapping in Autopolyploids: A Random-Effect Model Approach with Application in a Hexaploid Sweetpotato Full-Sib Population.

In developing countries, the sweetpotato,ipomoea batatas(l.) lam.[formula: see text], is an important autopolyploid species, both socially and economically.However, quantitative trait loci (qtl) mapping has remained limited due to its genetic complexity.Current fixed-effect models can fit only a single qtl and are generally hard to interpret.Here, we report the use of a random-effect model approach to map multiple qtl based on score statistics in a sweetpotato biparental population ('beauregard' × 'tanzania') with 315 full-sibs.Phenotypic data were collected for eight yield component traits in six environments in peru, and jointly adjusted means were obtained using mixed-effect models.An integrated linkage map consisting of 30,684 markers distributed along 15 linkage groups (lgs) was used to obtain the genotype conditional probabilities of putative qtl at every centi morgan position.Multiple interval mapping was performed using our r package qtlpoly and detected a total of 13 qtl, ranging from none to four qtl per trait, which explained up to 55% of the total variance.Some regions, such as those on lgs 3 and 15, were consistently detected among root number and yield traits, and provided a basis for candidate gene search.In addition, some qtl were found to affect commercial and noncommercial root traits distinctly.Further best linear unbiased predictions were decomposed into additive allele effects and were used to compute multiple qtl-based breeding values for selection.Together with quantitative genotyping and its appropriate usage in linkage analyses, this qtl mapping methodology will facilitate the use of genomic tools in sweetpotato breeding as well as in other autopolyploids.

Journal: Genetics (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Comparison of Visual Outcomes and Patient Satisfaction After Bilateral Implantation of an EDOF IOL and a Mix-and-Match Approach.

To evaluate visual outcomes at different distances (near, intermediate, and far), depth of focus, optical quality, quantitative dysphotopsia, and patient satisfaction in two groups.Methods the extended depth of focus (edof) only group (n = 40 eyes) was implanted bilaterally with an edof intraocular lens (iol) and the mixed group (n = 40 eyes) was implanted with the same edof iol in the dominant eye and a trifocal iol in the fellow eye.At the 3-month postoperative visit, refractive outcomes and monocular and binocular uncorrected (udva) and corrected (cdva) distance visual acuities for far udva, cdva, distance-corrected intermediate visual acuity (dciva) at 80 cm, uncorrected near visual acuity (unva), distance-corrected near visual acuity (dcnva) at 40 cm, and binocular defocus curve were evaluated.Results the mean spherical equivalent (se) 3 months postoperatively was -0.16 ± 0.41 diopters (d) in the edof only group and -0.39 ± 0.63 d in the mixed group.In the edof only group, binocular visual acuities were: udva = -0.04 ± 0.07 log mar (20/18); cdva = -0.04 ± 0.06 log mar (20/18); dciva (80 cm) = 0.07 ± 0.19 log mar (20/23); dcnva (40 cm) = 0.32 ± 0.15 log mar (20/42); and unva (40 cm) = 0.24 ± 0.17 log mar (20/35).In the mixed group, binocular visual acuities were: udva = 0.03 ± 0.09 log mar (20/21) (p = .08); cdva = -0.01 ± 0.07 log mar (20/20) (p = .25); dciva (80 cm) = 0.24 ± 0.23 log mar (20/35) (p = .08); dcnva (40 cm) = 0.19 ± 0.07 log mar (20/31) (p = .03); and unva (40 cm) = 0.18 ± 0.10 log mar (20/30) (p = .37).Conclusions effective restoration of visual acuity was demonstrated in both groups, with high levels of visual quality and patient satisfaction.Better results in near visual acuity were demonstrated in the mixed group.[j refract surg.2019;35(7):408-416.].

Journal: Journal of refractive surgery (Thorofare, N.J. : 1995) (2019)
Publication types: Comparative Study;Journal Article;Randomized Controlled Trial
Development of a Theory-Informed Behavior Change Intervention to Reduce Inappropriate Prescribing of Nephrotoxins and Renally Eliminated Drugs.

Goals of managing patients with acute kidney injury (aki) are mitigating disease progression and ensuring safety while providing supportive care because no effective treatment exists.One strategy recommended in guidelines to meet these goals is optimizing medication management.Unfortunately, guideline implementation appears to be lacking as observed by the frequent occurrence of medication errors and adverse drug events.Objective to address this performance gap in the care of hospitalized patients receiving nephrotoxins and renally eliminated drugs, we sought to provide a potential intervention based on theory-informed behavior change.Methods formative research with a qualitative analysis identifying what needs to change in patient care was completed by obtaining clinician opinion and expert opinion and reviewing the published literature.Frontline providers, including 8 physicians, 4 pharmacists, and a multiprofessional group of authors, provided insight into possible barriers to appropriate prescribing.Capability, opportunity, motivation and behavior model and theoretical domain framework were applied to characterize behavior change interventions and inform a potential implementation intervention for changing inappropriate prescribing behaviors.Results lack of knowledge about appropriate drug management in patients at risk for adverse outcomes was provided as a major barrier.Other reported barriers included a lack of: (1) tools to assist with drug management, (2) motivation to make changes, (3) routinization, and (4) an accountable clinician.Conclusions and relevance assigning a designated clinician to execute a stepwise, routine care process following the checklist provided is a recommended intervention to overcome barriers.The intended impact is behavior change that reduces inappropriate prescribing.

Journal: The Annals of pharmacotherapy (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Collective Mid-Infrared Vibrations in Surface-Enhanced Raman Scattering.

Surface-enhanced raman scattering (sers) is typically assumed to occur at individual molecules neglecting intermolecular vibrational coupling.Here, we show instead how collective vibrations from infrared (ir) coupled dipoles are seen in sers from molecular monolayers.Mixing ir-active molecules with ir-inactive spacer molecules controls the intermolecular separation.Intermolecular coupling leads to vibrational frequency upshifts up to 8 cm-1, tuning with the mixing fraction and ir dipole strength, in excellent agreement with microscopic models and density functional theory.These cooperative frequency shifts can be used as a ruler to measure intermolecular distance and disorder with angstrom resolution.We demonstrate this for photochemical reactions of 4-nitrothiophenol, which depletes the number of neighboring ir-active molecules and breaks the collective vibration, enabling direct tracking of the reaction.Collective molecular vibrations reshape sers spectra and need to be considered in the analysis of vibrational spectra throughout analytical chemistry and sensing.

Journal: Nano letters (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Foot and ankle biomechanics during walking in older adults: A systematic review and meta-analysis of observational studies.

The foot and ankle complex undergoes significant structural and functional changes with advancing age.Research question the objective of this systematic review and meta-analysis was to synthesize and critique the research literature pertaining to foot and ankle biomechanics while walking in young and older adults.Methods electronic databases (web of science, pub med, scopus and embase) were searched from inception to april 2019 for cross-sectional studies which compared kinematics, kinetics and plantar pressure differences between young and older adults.Screening and data extraction were performed by two independent assessors, with disagreements resolved by consensus.Results a total of 39 articles underwent full-text screening, and 19 articles met the inclusion criteria and were included.Meta-analysis showed that older adults had less ankle joint plantar flexion (5 studies; weighted mean difference [wmd]: -5.15; 95 %ci: -6.47 to -3.83; p < 0.001) and less ankle joint power generation (6 studies; standardized mean difference [smd]: -0.62; 95 %ci: -0.82 to -0.41; p < 0.001) during propulsion compared to young adults.These differences persisted in subgroup analyses comparing different walking speeds.Plantar pressure findings were highly variable due to differences in data collection protocols and meta-analysis was not possible.Significance older adults have unique foot and ankle kinematics and kinetics during walking characterized by reduced ankle joint plantarflexion and power generation during propulsion.

Journal: Gait & posture (2021)
Publication types: Journal Article;Meta-Analysis;Research Support, Non-U.S. Gov't;Review;Systematic Review
Concentrated poverty, ambient air pollution, and child cognitive development.

Why does growing up in a poor neighborhood impede cognitive development?Although a large volume of evidence indicates that neighborhood poverty negatively affects child outcomes, little is known about the mechanisms that might explain these effects.In this study, we outline and test a theoretical model of neighborhood effects on cognitive development that highlights the mediating role of early life exposure to neurotoxic air pollution.To evaluate this model, we analyze data from a national sample of american infants matched with information on their exposure to more than 50 different pollutants known or suspected to harm the central nervous system.Integrating methods of causal inference with supervised machine learning, we find that living in a high-poverty neighborhood increases exposure to many different air toxics during infancy, that it reduces cognitive abilities measured later at age 4 by about one-tenth of a standard deviation, and that about one-third of this effect can be attributed to disparities in air quality.

Journal: Science advances (2022)
Publication types: Journal Article
The Moderating Effect of Store Format on the Relationships Between ICT, Innovation and Sustainability in Retailing.

Innovation and sustainability are postulated as key variables for the future of large commercial distribution.In addition, the development of information and communication technologies (ict) solutions, and especially those related to artificial intelligence (i.e., just walk out, intelligent retail lab) and digitization, are particularly relevant factors in the current pandemic scenario in which retail companies operate.These tools are essential to face the derived changes in commercial relations, especially between companies and consumers.For all these reasons, this work aims to examine the effect of ict, as a driving factor for innovation and its direct and indirect impact on sustainability in retailing.Furthermore, this study takes into account the eventual differences in these relationships according to the types of store formats.To achieve the aforementioned objective, a theoretical model is proposed that is tested through an empirical study carried out on a sample of 510 consumers of three store formats of grocery retail formats (i.e., hypermarkets, supermarkets and discount stores) in spain.For the analysis of the data obtained, the partial least squares (pls) regression technique and the multigroup analysis were used.The results obtained confirm the direct and indirect effect of ict on innovation and sustainability in grocery retailing.In addition, the results indicate that consumers unequally perceive the technological progress of companies.These differences are greater between discount stores versus hypermarkets and supermarkets.The larger the size of the store format, the higher the incidence of ict in relation to innovation.Therefore, it is vital to take ict into consideration, where artificial intelligence is imperative for the growth and development of sustainable competitive advantages in retail companies.

Journal: Frontiers in psychology (2021)
Publication types: Journal Article
Chromatin Domain Organization of the TCRb Locus and Its Perturbation by Ectopic CTCF Binding.

Ctcf-mediated chromatin interactions influence organization and function of mammalian genome in diverse ways.We analyzed the interactions among ctcf binding sites (cbs) at the murine tcrb locus to discern the role of ctcf-mediated interactions in the regulation of transcription and vdj recombination.Chromosome conformation capture analysis revealed thymocyte-specific long-range intrachromosomal interactions among various cbs across the locus that were relevant for defining the limit of the enhancer eb-regulated recombination center (rc) and for facilitating the spatial proximity of tcrb variable (v) gene segments to the rc.Ectopic ctcf binding in the rc region, effected via genetic manipulation, altered cbs-directed chromatin loops, interfered with rc establishment, and reduced the spatial proximity of the rc with trbv segments.Changes in chromatin loop organization by ectopic ctcf binding were relatively modest but influenced transcription and vdj recombination dramatically.Besides revealing the importance of ctcf-mediated chromatin organization for tcrb regulation, the observed chromatin loops were consistent with the emerging idea that cbs orientations influence chromatin loop organization and underscored the importance of cbs orientations for defining chromatin architecture that supports vdj recombination.Further, our study suggests that in addition to mediating long-range chromatin interactions, ctcf influences intricate configuration of chromatin loops that govern functional interactions between elements.

Journal: Molecular and cellular biology (2017)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Pathological relevance and treatment perspective of JAK targeting in systemic lupus erythematosus.

Introduction the pathogenesis of systemic lupus erythematosus (sle) involves abnormalities in both acquired and innate immune system, which is mediated by numerous cytokines.Janus kinase (jak) plays important roles in the signaling pathways of those cytokines and is an attractive therapeutic target for sle.Currently, multiple clinical trials using jak inhibitors with different selectivities for jak family proteins are being conducted in sle.Area covered in this article, we provide an overview of the pathological relevance of jak and the clinical implications of jak inhibitors in sle based on recent reports.Expert opinion jak inhibitors have the potential to modulate various immune networks through a variety of mechanisms, potentially regulating the complex immunopathogenesis in sle.Sle is a clinically and immunologically heterogeneous disease; therefore, precision medicine is required to maximize the efficacy of jak inhibitors.Further studies are needed to determine their risk-benefit ratio and selection of the most appropriate patients for jak inhibitors.

Journal: Expert review of clinical immunology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Impact of Extreme Obesity and Diet-Induced Weight Loss on the Fecal Metabolome and Gut Microbiota.

Scope a limited number of human studies have characterized fecal microbiota and metabolome in extreme obesity and after diet-induced weight loss.Methods and results fecal samples from normal-weight and extremely obese adults and from obese participants before and after moderate diet-induced weight loss are evaluated for their interaction with the intestinal adenocarcinoma cell line ht29 using an impedance-based in vitro model, which reveals variations in the interaction between the gut microbiota and host linked to obesity status.Microbiota composition, short chain fatty acids, and other intestinal metabolites are further analyzed to assess the interplay among diet, gut microbiota, and host in extreme obesity.Microbiota profiles are distinct between normal-weight and obese participants and are accompanied by fecal signatures in the metabolism of biliary compounds and catecholamines.Moderate diet-induced weight loss promotes shifts in the gut microbiota, and the primary fecal metabolomics features are associated with diet and the gut-liver and gut-brain axes.Conclusions analyses of the fecal microbiota and metabolome enable assessment of the impact of diet on gut microbiota composition and activity, supporting the potential use of certain fecal metabolites or members of the gut microbiota as biomarkers for the efficacy of weight loss in extreme obesity.

Journal: Molecular nutrition & food research (2021)
Publication types: Controlled Clinical Trial;Journal Article;Research Support, Non-U.S. Gov't
Consanguinity and Increased Risk of Congenital Ptosis: A Case-Control Study from Southern Iran.

To assess consanguinity as a probable risk factor for congenital ptosis.Methods in this case-control study, 97 patients with congenital ptosis and 97 participants as the control group were included.The age, sex, and residence area of the control group were matched with the cases.The inbreeding coefficient (f) was calculated for each participant, and the mean of the inbreeding coefficient (α) was calculated for each group.Results the prevalence of consanguineous marriage in parents of cases with congenital ptosis and those of the control group was 54.6% and 30.9%, respectively (p< 0.002).The mean of the inbreeding coefficient (α) in patients with ptosis was 0.026, whereas it was 0.016 in the control group (t = 2.51, degree of freedom = 192,p= 0.0129).Conclusions the rate of consanguineous marriage was significantly higher among the parents of patients with congenital ptosis.It implies a probable recessive pattern in the etiology of congenital ptosis.

Journal: Journal of current ophthalmology (2022)
Publication types: Journal Article