syedzayyan/paper_mill_benchmark huggingface dataset:
How to diagnose renal artery stenosis correctly using ultrasound? Evaluation of results of renal arteries duplex ultrasonography examinations.

Renal artery duplex ultrasonography (rdu) is an effective and non-invasive screening test in diagnosing renal artery stenosis.The discordance of results in multiple rdu is common.We aim to evaluate the discordance and the reasons for discordance between diagnoses and measurements from multiple rdu examinations.Material and method a retrospective study was performed in 64 examinations of renal arteries from 32 patients that were referred for two or more rdu examinations and renal artery digital subtraction angiography (dsa) within six months, between august 2013 and january 2016.Using dsa as gold standard, we divided the renal arteries into three groups: discordant (one diagnosis of rdu was correct and one was wrong), misdiagnosed (neither rdu diagnosis was correct) and correct (both rdu diagnoses were correct) groups.we evaluated the discordance and reasons for discordance of diagnoses and measurements from multiple rdu examinations.Results: among 64 renal arteries included in this study, 37 renal arteries had two correct diagnoses, 19 renal arteries had two discordant diagnoses, and eight renal arteries were misdiagnosed twice by rdu.The discordance of peak systolic velocity (psv), the ratio between psv in the renal artery with stenosis and psv in the aorta (rar), and tardus-parvus waveform measurements were clearly higher in the discordant diagnoses group than in the correctly diagnosed group.The most common reason for a discordant diagnosis was failure in obtaining correct tardus-parvus waveforms of the interlobar artery (26.31%).Themost common reason for misdiagnosis was the presence of an extremely severe stenosis with an atrophic kidney (31.25%).Overall, 87.50% of patients underwent rdu examinations had correct diagnoses of stenosis or occlusion at least once (including location and degree), as confirmed by dsa.Conclusions our study indicates that standard operating procedures and improvements in examination technique by ultrasound doctors could reduce the discordance between multiple tests.

Journal: Medical ultrasonography (2018)
Publication types: Journal Article
Clinical prediction of laboratory-confirmed influenza in adults with influenza-like illness in primary care. A randomized controlled trial secondary analysis in 15 European countries.

Clinical findings do not accurately predict laboratory diagnosis of influenza.Early identification of influenza is considered useful for proper management decisions in primary care.Objective we evaluated the diagnostic value of the presence and the severity of symptoms for the diagnosis of laboratory-confirmed influenza infection among adults presenting with influenza-like illness (ili) in primary care.Methods secondary analysis of patients with ili who participated in a clinical trial from 2015 to 2018 in 15 european countries.Patients rated signs and symptoms as absent, minor, moderate, or major problem.A nasopharyngeal swab was taken for microbiological identification of influenza and other microorganisms.Models were generated considering (i) the presence of individual symptoms and (ii) the severity rating of symptoms.Results a total of 2,639 patients aged 18 or older were included in the analysis.The mean age was 41.8 ± 14.7 years, and 1,099 were men (42.1%).Influenza was microbiologically confirmed in 1,337 patients (51.1%).The area under the curve (auc) of the model for the presence of any of seven symptoms for detecting influenza was 0.66 (95% confidence interval [ci]: 0.65-0.68), whereas the auc of the symptom severity model, which included eight variables-cough, fever, muscle aches, sweating and/or chills, moderate to severe overall disease, age, abdominal pain, and sore throat-was 0.70 (95% ci: 0.69-0.72).Conclusion clinical prediction of microbiologically confirmed influenza in adults with ili is slightly more accurate when based on patient reported symptom severity than when based on the presence or absence of symptoms.

Journal: Family practice (2022)
Publication types: Journal Article;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
Establishing and comparing reference preoperative Patient-Reported Outcomes Measurement Information System (PROMIS) scores in patients undergoing shoulder surgery.

The patient-reported outcomes measurement information system (promis) has become increasingly popular among orthopedic surgeons treating shoulder pathology.Despite this, there have been few studies that have described and compared preoperative reference scores for specific shoulder surgical procedures.The primary purpose of this study was to establish and compare baseline preoperative promis scores for 3 common types of shoulder surgery: rotator cuff repair (rcr), total shoulder arthroplasty (tsa), and labral repair (lr).The secondary goal was to stratify these operative groups by diagnosis and compare preoperative promis scores.Methods in this cross-sectional study, adult and pediatric patients who underwent surgery for either rcr, tsa, or lr were included.Promis-upper extremity (ue), promis-pain interference (pi), and promis-depression (d) scores that were collected at each patient's preoperative visit were reviewed.Continuous and categorical variables were compared between operative groups using analysis of variance and χ2or fisher exact tests, respectively.Multivariable general linear models were used to identify significant independent predictors of promis scores when controlling for age, sex, and body mass index.Results a total of 413 patients were included in the study: 272 in the rcr group, 84 in the tsa group, and 57 in the lr group.The average promis-ue score was 39.8 in the lr group vs.29.9 in the rcr group (p < .001) and 29.6 in the tsa group (p < .001).There was no difference between the mean rcr and tsa promis-ue scores (p = .93).The average promis-pi score was 56.6 in the lr group vs.62.8 in the rcr group (p < .001) and 63.9 in the tsa group (p < .001).There was no difference between rcr and tsa promis-pi scores (p = .09).The average promis-d score was 43.5 in the lr group vs.47.7 in the rcr group (p = .004) and 50.3 in the tsa group (p < .001).The tsa group had a higher mean promis-d score than the rcr group (p = .03).For promis-ue scores, age and body mass index were not found to be significant independent predictors (p = .98 and p = .88, respectively).For promis-pi scores, age, body mass index, and sex were not found to be significant independent predictors (p = .31, p = .81, and p = .48, respectively).Conclusion patients undergoing shoulder lr had higher preoperative function scores and lower pain interference and depression scores than those undergoing tsa and rcr.These baseline promis scores should be taken into consideration when tracking a patient's outcomes after surgery, as a certain score could mean drastically different functional and pain outcomes depending on the underlying pathology.

Journal: Journal of shoulder and elbow surgery (2021)
Publication types: Journal Article
Enhanced electrocatalytic activity of PtRu/nitrogen and sulphur co-doped crumbled graphene in acid and alkaline media.

The low mass activity and high price of pure platinum (pt)-based catalysts predominantly limit their large-scale utilization in electrocatalysis.Therefore, the reduction of pt amount while preserving the electrocatalytic efficiency represents a viable alternative.In this work, we prepared new pt ru2nanoparticles supported on sulphur and nitrogen co-doped crumbled graphene with trace amounts of iron (pt ru2/pf) electrocatalysts.The pt ru2/pf catalysts exhibited enhanced electrocatalytic performance and stability for the hydrogen evolution reaction (her) at p h = 0.Moreover, the prepared pt ru2/pf electrocatalyst displayed higher her activity than commercial 20% pt/c.The pt ru2/pf catalyst achieved a current density of 10 m a cm-2at an overpotential value of only 22 m v for her, performing better activity than many other pt-based electrocatalysts.Besides, the pt ru2/pf revealed a good performance for the oxygen reduction reaction (orr) and oxygen evolution reaction (oer) in alkaline media.The pt ru2/pf catalyst recorded a current density of 10 m a cm-2at an overpotential of only 270 m v for oer in koh (1.0 m) solution and an onset potential of 0.96 v vs.Rhe (at 1 m a cm-2) for orr in koh (0.1 m) solution.

Journal: Journal of colloid and interface science (2021)
Publication types: Journal Article
Preparation of a stabilized aqueous polystyrene suspensionviaphase inversion.

Polymer suspensions have found various applications in novel technologies.In this research, an aqueous suspension of polystyrene was preparedviathe phase inversion method using sodium lauryl sulfate (sls) as an anionic surfactant and two co-surfactants.The effects of co-surfactant ratio and salt concentration were investigated and the stability and characteristics of the prepared samples were identified.All samples possessed a zeta potential lower than -50 m v which reveals an electrostatic stability.The sample ps-1, containing the lower salt concentration of 1 × 10-3m, was the most stable sample, while its stability decreases with increasing salt concentration.The sample ps-5 during the electrical conductivity measurement exhibited partial instabilityviaagglomeration of polymer on the probe.Rheology measurements revealed that the suspension behavior varies between newtonian and non-newtonian.Eventually, ps-1 containing 4.00 g polystyrene, 1.70 g sls and a co-surfactant ratio of 0.66, suspended within 150 m l of 0.003 m aqueous na cl solution, exhibited proper stability.

Journal: RSC advances (2021)
Publication types: Journal Article
Concurrent Nivolumab and Metformin in Diabetic Cancer Patients: Is It Safe and More Active?

/aim recent evidence suggests potential synergistic antitumor effects of the combination of programmed death-1 (pd-1)/programmed death-ligand 1 (pd-l1) immune checkpoint inhibitors with the oral hypoglycemic agent metformin.The aim of this study was to investigate the safety and activity of metformin combined with nivolumab in diabetic cancer patients.Patients and methods patients with advanced melanoma, renal cell carcinoma or lung cancer receiving nivolumab with concurrent diabetes treated with metformin were retrospectively collected.The primary endpoint was the safety of nivolumab plus metformin combination.Results we collected 40 patients with solid tumors who received metformin for concomitant diabetes and nivolumab as anticancer therapy in four italian hospitals.The concomitant use of nivolumab and metformin was well tolerated; adverse events (aes) of any grade occurred in 75% of patients (mainly fatigue, pruritus, rash, and asthenia).Grade 3 aes occurred only in 20% of cases; no grade 4 aes were observed.A statistically significant correlation was found between higher doses of metformin (>1,000 mg daily) and longer progression-free survival (p=0.021), overall survival (p=0.037) and higher overall response rate.Conclusion the combination of nivolumab and metformin was safe and might have an antitumor activity, supporting further investigations on the synergistic antitumor effect of this combination.

Journal: Anticancer research (2022)
Publication types: Journal Article;Multicenter Study
Arsenic accumulation in rice: Alternative irrigation regimes produce rice safe from arsenic contamination.

The natural occurrence of arsenic (as) in groundwater & soils and its bioaccumulation in rice grains is a major health concern worldwide.To combat the problem, best combination of irrigation management and suitable rice variety altering as content in grains must be ensured.With this aim, a field trial was conducted with two rice varieties and water management including alternate wetting and drying (awd) and continuous flooding (cf) irrigation regimes with as contaminated groundwater (as w) and temporarily stored groundwater (tsg) and river water for only cf (as control).Results revealed that as content in different portions of paddy plant was significantly different (p < 0.001) with irrigation practices and rice varieties.Awd irrigation with tsg accumulated lower as in rice grains compared with cf-as w for both varieties.Data showed that awd-tsg practice led to 61.37% and 60.34% grain as reduction for brri dhan28 and brri dhan29, respectively, compared with cf-as w.For principle component analysis (pca), first principle component (pc1) explained 91.7% of the variability and irrigation water as, soil total and available as, straw as, root as and husk as were the dominating parameters.With significant (p < 0.05) variation in yields between the genotypes, awd increased grain yield by 29.25% in brri dhan29 compared with cf.However, translocation factor (tf) and bioconcentration factor (bcf) for both varieties were less than one for all the treatments.The addition of this study to our knowledge base is that, awd-tsg with brri dhan29 can be an as-safe practice without compromising yields.

Journal: Environmental pollution (Barking, Essex : 1987) (2022)
Publication types: Journal Article
Nipah Virus Infection Generates Ordered Structures in Cellulo.

Nipah virus (ni v) is a zoonotic paramyxovirus with a fatality rate of up to 92% in humans.While several pathogenic mechanisms used by ni v to counteract host immune defense responses have been described, all of the processes that take place in cells during infection are not fully characterized.Here, we describe the formation of ordered intracellular structures during ni v infection.We observed that these structures are formed specifically during ni v infection, but not with other viruses from the same mononegaviralesorder (namely ebola virus) or from other orders such as bunyavirales(junín virus).We also determined the kinetics of the appearance of these structures and their cellular localization at the cellular periphery.Finally, we confirmed the presence of these ni v-specific ordered structures using structured illumination microscopy (sim), as well as their localization by transmission electron microscopy (tem), scanning electron microscopy (sem), and correlative light and electron microscopy (clem).Herein, we describe a cytopathogenic mechanism that provides a new insight into ni v biology.These newly described ordered structures could provide a target for novel antiviral approaches.

Journal: Viruses (2022)
Publication types: Journal Article
CKD Prevalence Varies across the European General Population.

Ckd prevalence estimation is central to ckd management and prevention planning at the population level.This study estimated ckd prevalence in the european adult general population and investigated international variation in ckd prevalence by age, sex, and presence of diabetes, hypertension, and obesity.We collected data from 19 general-population studies from 13 european countries.Ckd stages 1-5 was defined as e gfr 30 mg/g, and ckd stages 3-5 was defined as e gfr<60 ml/min per 1.73 m(2) ckd prevalence was age- and sex-standardized to the population of the 27 member states of the european union (eu27).We found considerable differences in both ckd stages 1-5 and ckd stages 3-5 prevalence across european study populations.The adjusted ckd stages 1-5 prevalence varied between 3.31% (95% confidence interval [95% ci], 3.30% to 3.33%) in norway and 17.3% (95% ci, 16.5% to 18.1%) in northeast germany.The adjusted ckd stages 3-5 prevalence varied between 1.0% (95% ci, 0.7% to 1.3%) in central italy and 5.9% (95% ci, 5.2% to 6.6%) in northeast germany.The variation in ckd prevalence stratified by diabetes, hypertension, and obesity status followed the same pattern as the overall prevalence.In conclusion, this large-scale attempt to carefully characterize ckd prevalence in europe identified substantial variation in ckd prevalence that appears to be due to factors other than the prevalence of diabetes, hypertension, and obesity.

Journal: Journal of the American Society of Nephrology : JASN (2016)
Publication types: Journal Article;Multicenter Study
A tRNA-derived fragment of ginseng protects heart against ischemia/reperfusion injury via targeting the lncRNA MIAT/VEGFA pathway.

Traditional chinese medicines (tcms) have been widely used for treating ischemic heart disease (ihd), and secondary metabolites are generally regarded as their pharmacologically active components.However, the effects of nucleic acids in tcms remain unclear.We reported for the first time that a 22-mer double-strand rna consisting of hc83 (a t rna-derived fragment [t rf] from the 3' end of t rnagln(uug)of ginseng) and its complementary sequence significantly promoted h9c2 cell survival after hypoxia/reoxygenation (h/r)in vitro.Hc83_mimic could also significantly improve cardiac function by maintaining both cytoskeleton integrity and mitochondrial function of cardiomyocytes.Furtherin vivoinvestigations revealed that hc83_mimic is more potent than metoprolol by >500-fold against myocardial ischemia/reperfusion (mi/r) injury.In-depth studies revealed that hc83 directly downregulated a lnc rna known as myocardial infarction-associated transcript (miat) that led to a subsequent upregulation of vegfa expression.These findings provided the first evidence that tcm-derived t rfs can exert mi rna-like functions in mammalian systems, therefore supporting the idea that tcm-derived t rfs are promising rna drug candidates shown to have extraordinarily potent effects.In summary, this study provides a novel strategy not only for discovering pharmacologically active t rfs from tcms but also for efficiently exploring new therapeutic targets for various diseases.

Journal: Molecular therapy. Nucleic acids (2022)
Publication types: Journal Article
Study of uncertainty of satellite and reanalysis precipitation products and their impact on hydrological simulation.

Satellite and reanalysis precipitation products are potential alternatives in hydrological studies, and it is very important to evaluate their accuracy and potential use for reliable simulations.In this study, three precipitation products (tropical rainfall measuring mission 3b43 version 7 (trmm 3b43), spatial interpolation grid data based on 2472 national meteorological observation stations in china (grid_0.5), and national centers for environmental prediction-climate forecast system reanalysis (ncep-cfsr)) were evaluated against gauge observations in the xiangxi river watershed of hubei province.The performance results indicated that the results of the three precipitation products were correlated with those of the rain gauges; however, there were differences among the three products.Trmm 3b43 tended to overestimate precipitation with the highest correlation coefficient, while ncep-cfsr tended to underestimate precipitation with the least satisfactory performance, and the performance of grid_0.5 ranked between them.However, the annual and monthly mean errors differed, as the errors of most of the results driven by ncep-cfsr were lowest.The errors varied at different time scales.During years with high precipitation, the results were often underestimated, while the results are often overestimated during years with low precipitation.According to the average monthly results, the grid_0.5 results were closest to the gauge observations for most months.During the wet season, trmm 3b43 performed better, while ncep-cfsr precipitation performed better during the dry season.The errors from precipitation to streamflow, nps pollution, and water environmental capacity (wec) driven by the three precipitation products increased gradually, ranging from 10% for precipitation to over 20% for nps pollution and almost 100% for wec.The error increase for ncep-cfsr was lower than that of the other two products.Although the simulation error from precipitation to the wec results driven by the three precipitation products gradually increased, the degree of overestimation and underestimation became smaller.

Journal: Environmental science and pollution research international (2021)
Publication types: Journal Article
Metabolomic analysis coupled with extreme phenotype sampling identified that lysophosphatidylcholines are associated with multisite musculoskeletal pain.

Musculoskeletal pain often occurs simultaneously at multiple anatomical sites.The aim of the study was to identify metabolic biomarkers for multisite musculoskeletal pain (msmp) by metabolomics with an extreme phenotype sampling strategy.The study participants (n = 610) were derived from the newfoundland osteoarthritis study.Musculoskeletal pain was assessed using a self-reported pain questionnaire where painful sites were circled on a manikin by participants and the total number of painful sites were calculated.Targeted metabolomic profiling on fasting plasma samples was performed using the biocrates absolute idq p180 kit.Plasma cytokine concentrations including tumor necrosis factor-α, interleukin-6, interleukin-1β, and macrophage migration inhibitory factor were assessed by enzyme-linked immunosorbent assay.Data on blood cholesterol profiles were retrieved from participants' medical records.Demographic, anthropological, and clinical information was self-reported.The number of reported painful sites ranged between 0 and 21.Two hundred and five participants were included in the analysis comprising 83 who had ≥7 painful sites and 122 who had ≤1 painful site.Women and younger people were more likely to have msmp (p ≤ 0.02).Multisite musculoskeletal pain was associated with a higher risk of having incontinence, worse functional status and longer period of pain, and higher levels of low-density lipoprotein and non-high-density lipoprotein cholesterol (all p ≤ 0.03).Among the 186 metabolites measured, 2 lysophosphatidylcholines, 1 with 26 carbons with no double bond and 1 with 28 carbons with 1 double bond, were significantly and positively associated with msmp after adjusting for multiple testing with the bonferroni method (p ≤ 0.0001) and could be considered as novel metabolic markers for msmp.

Journal: Pain (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Interluekin-6 inhibitors for the treatment of adult-onset Still's disease.

Adult-onset still's disease is a systemic inflammatory disease characterized by high spiking fever, arthritis, evanescent skin rash, leukocytosis, and hyperferritinemia.The pathogenesis of adult-onset still's disease has not been fully understood yet; however, multiple proinflammatory cytokines, such as il-1β and il-6, play important roles in the development of adult-onset still's disease.Il-6 is a multifunctional cytokine that accelerates the differentiation of macrophages and cytotoxic t-cells and chemotaxis of neutrophils and macrophages.Serum concentrations of il-6 well correlate with disease activity of adult-onset still's disease, and blockade of il-6 has been proven to be effective in active adult-onset still's disease.This review will focus on the recent understanding of the role of proinflammatory cytokines of adult-onset still's disease and the efficacy of il-6 inhibitors for the treatment of adult-onset still's disease.

Journal: Modern rheumatology (2022)
Publication types: Journal Article;Review
Cytogenetic Biomonitoring in Buccal Mucosa Cells from Seaport Dockers.

/aim dockers of seaport working as stevedores are self-employed workers who carry out arduous and dangerous activities.To date, few studies have investigated the human health risks in these professionals.The aim of this study was to evaluate cytogenetic damage in oral cells of dockers of seaports working as stevedores by micronucleus assay in buccal cells.Patients and methods for this study, a total of 26 seaport dockers working as stevedores aged 51.2±8.4 years (all men) were included in this study.All volunteers had worked for at least 3 years.The control group consisted of 25 participants aged 55.2±9.9 years (all men), who did not work in the port of santos city.Results the results showed statistically significant differences (p 0.05) between groups.Conclusion the results of the present study suggest that seaport dockers present mutagenicity in oral cells.

Journal: Cancer diagnosis & prognosis (2022)
Publication types: Journal Article