syedzayyan/paper_mill_benchmark huggingface dataset:
A new affordable and easy-to-make pelvic model for training in complex urogynecological laparoscopic procedures.

Introduction and hypothesis our aim was to introduce a new affordable and easy-to-make pelvic model for training in complex urogynecological laparoscopic procedures.Methods we modified a commercial female pelvic model consisting of sacrum, coccyx, two hip bones, the pubic symphysis, the fifth lumbar vertebra with intervertebral disc, and certain pelvic ligaments.We used sponge foam paper, felt fabric pieces, chenille stems, foam, plastic ties, fabric glue, and a thick, coated wire to create pelvic floor, uterus/vaginal cuff, bladder, both ureters, and anterior longitudinal and pectineal ligaments.Results we created two different pelvic models: one with the uterus and one with the vaginal cuff.They enable training for laparoscopic pectopexy and hysteropexy/sacrocolpopexy.Trainees can practice proper mesh placement and suture the mesh to the corresponding anatomical structures.Because of the wire inserted in the uterus/vaginal cuff, it is possible to move the uterus/vaginal cuff in the anterior-posterior direction, thus mimicking the use of the manipulator during surgery.Besides the basic pelvis, all other parts of the model can be easily replaced when necessary.Conclusions we believe that our pelvic model could provide a valuable tool for training complex urogynecological laparoscopic procedures and help to reduce the long learning curve of these procedures.

Journal: International urogynecology journal (2019)
Publication types: Journal Article
Maternal and Perinatal Outcomes of White Coat Hypertension During Pregnancy: A Systematic Review and Meta-Analysis.

The aim of this meta-analysis is to investigate whether white-coat hypertension (wch) has an adverse effect on maternal, fetal, and neonatal outcomes.Medline, embase, www.clinicaltrials.gov, and cochrane library databases were searched electronically in december 2019.The outcomes were compared between pregnant women with wch and normotensive controls, women with chronic hypertension, gestational hypertension or any hypertensive disorder of pregnancy.Twelve studies were eligible for inclusion in the systematic review.Women with wch enrolled below 20 weeks had a significantly increased risk of preeclampsia (pooled risk ratio [rr], 5.43 [95% ci, 2.00-14.71]).Furthermore, women with wch had increased risk of delivering a small-for-gestational-age newborn (rr, 2.47 [95% ci, 1.21-5.05],p=0.013) and preterm birth (rr, 2.86 [95% ci, 1.44-5.68],p=0.002).The risk of preeclampsia (risk ratio, 0.43 [95% ci, 0.23-0.78],p=0.005), small-for-gestational-age (rr, 0.46 [95% ci, 0.26-0.82],p=0.008), preterm birth (rr, 0.47 [95% ci, 0.31-0.71],p<0.001) were significantly lower with wch compared with women with gestational hypertension.Women with wch delivered ≈1 week later compared with women with chronic hypertension (mean difference, 1.06 weeks [95% ci, 0.44-1.67 weeks];p<0.001).Wch is associated with a worse perinatal and maternal outcome than normotension, but better outcomes than gestational hypertension and chronic hypertension.Therefore, diagnosis of wch should be ascertained in pregnant women presenting with hypertension.When the diagnosis is confirmed, these women require monitoring for developing preeclampsia, small-for-gestational-age and preterm birth.

Journal: Hypertension (Dallas, Tex. : 1979) (2020)
Publication types: Journal Article;Meta-Analysis;Systematic Review
Efficacy, safety, and tolerability of adjunctive perampanel in patients from China with focal seizures or generalized tonic-clonic seizures: Post hoc analysis of phase III double-blind and open-label extension studies.

S this post hoc analysis assessed the efficacy and safety/tolerability of adjunctive perampanel in patients from china (aged ≥12 years) with focal seizures (fs), with/without focal to bilateral tonic-clonic seizures (fbtcs), or generalized tonic-clonic seizures (gtcs).Methods study centers in china were identified using data from five double-blind, randomized, phase iii studies of adjunctive perampanel (2-12 mg/day) and their open-label extensions (olex).Efficacy assessments included median percent reduction in seizure frequency per 28 days, and 50% and 75% responder and seizure-freedom rates.Safety/tolerability assessments included monitoring of treatment-emergent adverse events (teaes).Results overall, 277 patients (placebo, n = 79; perampanel, n = 198) were included in the double-blind safety analysis set.The full analysis set comprised 274 patients (fs, n = 238 [placebo, n = 60; perampanel, n = 178]; fbtcs, n = 120 [placebo, n = 31; perampanel, n = 89]; gtcs, n = 36 [placebo, n = 18; perampanel, n = 18]).Median percent reductions in seizure frequency for placebo vs perampanel were as follows: 16.6% vs 32.4% (fs; p < 0.05) and 39.1% vs 48.2% (fbtcs; not significant [ns]) at 4-12 mg/day, and 37.9% vs 82.6% (gtcs; ns) at 8 mg/day; 50% responder rates were 31.7% vs 37.4% (fs; ns), 48.4% vs 51.9% (fbtcs; ns), and 33.3% vs 61.1% (gtcs; ns), respectively.Seizure-freedom rates were 1.7% vs 9.2%, 16.1% vs 25.3%, and 16.7% vs 44.4%, respectively (all ns).Overall, 262 patients entered the olex (fs, n = 228; gtcs, n = 34).Perampanel was efficacious for up to four years for fs and fbtcs and up to two years for gtcs.Across the double-blind and olex studies, teaes were reported in 65.7% and 81.3% of perampanel-treated patients, respectively; the most common was dizziness.Efficacy and safety/tolerability outcomes were generally similar between chinese and non-chinese patients.Conclusion adjunctive perampanel (up to 12 mg/day) may be a suitable treatment for chinese patients with fs, with/without fbtcs, or gtcs, with similar efficacy and safety/tolerability compared to non-chinese patients.

Journal: CNS neuroscience & therapeutics (2021)
Publication types: Clinical Trial, Phase III;Journal Article;Multicenter Study;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
Protocol for a scoping review on the conceptualisation of learning in undergraduate clinical nursing practice.

Introduction learning in the clinical setting is a major form of learning in undergraduate nursing education.In spite of this, how nursing students learn in clinical practice is still largely unknown.Moreover, there is no conceptual clarity on learning in practice in the current literature.This paper aims to set up a protocol for a scoping review of the literature in order to map different conceptualisations of learning in practice in undergraduate clinical nursing education in the hospital setting.The operationalisations of different concepts will be compared and the findings of the studies will be synthesised.Methods and analysis this scoping review will be guided by the methodological framework proposed by arksey and o'malley and refined by levacet al.and the joanna briggs institute.The search strategy will be developed together with a medical information specialist and the search will be performed in electronic databases (pub med, ebsco/eric and ebsco/cinahl).In a first search, we will identify concepts that are used as an equivalent to learning in practice.Next, we will search for studies operationalising these concepts in undergraduate nursing education.Finally, we will check reference lists for additional publications.Abstracts and full-text studies will independently be screened by two researchers.All studies that have 'learning in undergraduate clinical nursing practice' as their main topic and that include a definition and operationalisation of an equivalent to learning in clinical practice, will be considered for inclusion.We will chart different conceptualisations and their theoretical underpinnings, as well as reported learning opportunities, informal and formal aspects of learning, social aspects of learning and gaps in the literature.Ethics and dissemination this review will help design future studies on learning in clinical nursing practice using well-defined and agreed on terminology.The results will be disseminated through journal publications and conference presentations.

Journal: BMJ open (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Systematic analysis of different low-pass filter cut-off frequencies on lumbar spine kinematics data and the impact on the agreement between accelerometers and an optoelectronic system.

A necessary step in the validation of accelerometers for the measurement of spine angles is to determine the levels of agreement with current gold standard methods.However, agreement may be a function of filtering parameters.We aimed to (1) systematically determine the effect of different filter frequency cut-offs on the peak range of motion (rom) during forward bending as measured by accelerometers and an optoelectronic (oe) system, (2) explore the influence of filtering on agreement between systems, and (3) determine the difference in peak rom measurement between these systems.Accelerometers and oe sensors were attached at l2, l4, and s1 of 20 asymptomatic female participants for a guided flexion trial.Signals were then iteratively low-pass filtered with cut-off frequencies ranging from 14 hz to 1 hz and peak range of motion outcome measures were compared between systems.Peak rom was minimally affected by filter cut-off frequency for both accelerometer and oe system.The difference in peak rom between difference cut-off frequencies were maximum 0.66°, median 0.18° and minimum 0.06° for accelerometer derived values and maximum 0.23°, median 0.08° and minimum 0.03° for the oe system.The maximum difference across the filtering frequencies was 0.62° and the largest difference between the two systems (with outliers removed) was 0.82°.Cut-off frequencies ranging from 14 to 1 hz had little effect of peak lumbar spine rom during low velocity (6°/s) forward bending, regardless of motion capture method.Filtering cut-off frequency had little effect on the differences between the accelerometer and oe system and similar measurements can be achieved using accelerometers compared to oe systems.

Journal: Journal of biomechanics (2022)
Publication types: Journal Article
Electrical Propagation of Condensed and Diffuse Ions Along Actin Filaments.

In this article, we elucidate the roles of divalent ion condensation and highly polarized immobile water molecules on the propagation of ionic calcium waves along actin filaments.We introduced a novel electrical triple layer model and used a non-linear debye-huckel theory with a non-linear, dissipative, electrical transmission line model to characterize the physicochemical properties of each monomer in the filament.This characterization is carried out in terms of an electric circuit model containing monomeric flow resistances and ionic capacitances in both the condensed and diffuse layers.We considered resting and excited states of a neuron using representative mono and divalent electrolyte mixtures.Additionally, we used 0.05v and 0.15v voltage inputs to study ionic waves along actin filaments in voltage clamp experiments.Our results reveal that the physicochemical properties characterizing the condensed and diffuse layers lead to different electrical conductive mediums depending on the ionic species and the neuron state.This region specific propagation mechanism provides a more realistic avenue of delivery by way of cytoskeleton filaments for larger charged cationic species.A new direct path for transporting divalent ions might be crucial for many electrical processes found in localized neuron elements such as at mitochondria and dendritic spines.

Journal: Journal of computational neuroscience (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
An improved correlation to predict molecular weight between crosslinks based on equilibrium degree of swelling of hydrogel networks.

Accurate characterization of hydrogel diffusional properties is of substantial importance for a range of biotechnological applications.The diffusional capacity of hydrogels has commonly been estimated using the average molecular weight between crosslinks (mc), which is calculated based on the equilibrium degree of swelling.However, the existing correlation linking mcand equilibrium swelling fails to accurately reflect the diffusional properties of highly crosslinked hydrogel networks.Also, as demonstrated herein, the current model fails to accurately predict the diffusional properties of hydrogels when polymer concentration and molecular weight are varied simultaneously.To address these limitations, we evaluated the diffusional properties of 48 distinct hydrogel formulations using two different photoinitiator systems, employing molecular size exclusion as an alternative methodology to calculate average hydrogel mesh size.The resulting data were then utilized to develop a revised correlation between mcand hydrogel equilibrium swelling that substantially reduces the limitations associated with the current correlation.© 2017 wiley periodicals, inc.J biomed mater res part b: appl biomater, 106b: 1339-1348, 2018.

Journal: Journal of biomedical materials research. Part B, Applied biomaterials (2018)
Publication types: Journal Article
Transforming the Choice Outcome to an Action Plan in Monkey Lateral Prefrontal Cortex: A Neural Circuit Model.

In economic decisions, we make a good-based choice first, then we transform the outcome into an action to obtain the good.To elucidate the network mechanisms for such transformation, we constructed a neural circuit model consisting of modules representing choice, integration of choice with target locations, and the final action plan.We examined three scenarios regarding how the final action plan could emerge in the neural circuit and compared their implications with experimental data.Our model with heterogeneous connectivity predicts the coexistence of three types of neurons with distinct functions, confirmed by analyzing the neural activity in the lateral prefrontal cortex (lpfc) of behaving monkeys.We obtained a much more distinct classification of functional neuron types in the ventral than the dorsal region of lpfc, suggesting that the action plan is initially generated in ventral lpfc.Our model offers a biologically plausible neural circuit architecture that implements good-to-action transformation during economic choice.

Journal: Neuron (2019)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Cystic Fibrosis and Sleep Circadian Rhythms.

Cystic fibrosis (cf) is due to a mutation in the cystic fibrosis transmembrane conductance regulator gene (cftr), which leads to unusual water and chloride secretion across epithelial surfaces.The lungs are responsible for most morbidity, though other organs are frequently affected.Sleep abnormalities have long been recognized in cf.Abnormal ventilation and oxygenation, sinus disease, deconditioning due to muscle weakness and recurrent infections, and inflammation have been thought to play a role in sleep disorders in cf.However, there is evidence that cftr gene dysregulation can affect circadian rhythms in cf.Early recognition and treatment of circadian rhythms may improve outcomes in cf.

Journal: Pulmonary therapy (2022)
Publication types: Journal Article;Review
Reliability and concurrent validity of mobile health technology for patient self-monitoring in physical rehabilitation.

Forearm pronation and supination are important for everyday functional tasks and some recreational activities.Healthcare providers use reliable and valid tools during the physical rehabilitation process to measure joint range of motion (rom), assess functional mobility, guide decisions for skilled interventions, and progress a plan of care.Since the onset of the covid-19 pandemic, both healthcare providers and patients benefited from mobile health technologies that have emerged, which can be used by patients in the home to monitor rom and assist the healthcare provider in guiding the rehabilitation process when utilizing telehealth.Purpose the goal of this study was to investigate the reliability and concurrent validity of a smartphone application for obtaining goniometric measurements of forearm pronation and supination.Methods this study consisted of 83 participants that were recruited on a voluntary basis from an academic institution.An i phone with the application clinometer and a standard goniometer (sg) were utilized to obtain goniometric measurements of forearm pronation and supination.The intraclass correlation coefficient (icc) was used to analyze intrarater reliability, and the pearson correlation coefficient was used to analyze concurrent validity.Scatterplots with regression lines were created to visually display the results.Results the smartphone demonstrated strong correlations for both pronation and supination (r = 0.71,p< .001; r = 0.73,p< .001).This study demonstrated overall good-excellent intrarater reliability and good concurrent validity for the smartphone application with a higher test-retest reliability in the measurement of forearm pronation compared to supination.Conclusions this study concludes that the reliability and concurrent validity of the smartphone was consistent with the sg for assessing forearm pronation and supination.It may be of value to further investigate interrater reliability between patient and healthcare practitioner, and report on the ease of use to assess rom with a smartphone.

Journal: JSES international (2022)
Publication types: Journal Article
Leveraging omics to understand the molecular basis of acute-on-chronic liver failure.

Acute-on-chronic liver failure (aclf) is a complex syndrome that develops in patients with acutely decompensated cirrhosis.In this condition, dysbalanced immune function and excessive systemic inflammation are closely associated with organ failure and high short-term mortality.In this review, we describe how omic technologies have contributed to the characterization of the hyperinflammatory state in patients with acutely decompensated cirrhosis developing aclf, with special emphasis on the role of metabolomics, lipidomics and transcriptomics in profiling the triggers (pathogen- and damage-associated molecular patterns [pamps and damps]) and effector molecules (cytokines, chemokines, growth factors and bioactive lipid mediators) that lead to activation of the innate immune system.This review also describes how omic approaches can be invaluable tools to accelerate the identification of novel biomarkers that could guide the implementation of novel therapies/interventions aimed at protecting these patients from excessive systemic inflammation and organ failure.

Journal: Advances in laboratory medicine (2021)
Publication types: Journal Article;Review
Metabolic Assessment of Human Induced Pluripotent Stem Cells-Derived Astrocytes and Fetal Primary Astrocytes: Lactate and Glucose Turnover.

Astrocytes represent one of the main cell types in the brain and play a crucial role in brain functions, including supplying the energy demand for neurons.Moreover, they are important regulators of metabolite levels.Glucose uptake and lactate production are some of the main observable metabolic actions of astrocytes.To gain insight into these processes, it is essential to establish scalable and functional sources for in vitro studies of astrocytes.In this study, we compared the metabolic turnover of glucose and lactate in astrocytes derived from human induced pluripotent stem cell (hi psc)-derived astrocytes (hi astrocytes) as a scalable astrocyte source to human fetal astrocytes (hfas).Using a user-friendly, commercial flow-based biosensor, we could verify that hi astrocytes are as glycogenic as their fetal counterparts, but their normalized metabolic turnover is lower.Specifically, under identical culture conditions in a defined media, hfas have 2.3 times higher levels of lactate production compared to hi astrocytes.In terms of glucose, hfas have 2.1 times higher consumption levels than hi astrocytes at 24 h.Still, as we describe their glycogenic phenotype, our study demonstrates the use of hi astrocytes and flow-based biosensors for metabolic studies of astrocyte function.

Journal: Biosensors (2022)
Publication types: Journal Article
A validated lower extremity model to investigate the effect of stabilizing knee components in pedestrian collisions.

Lower extremity injuries account for over 50% of pedestrian orthopedic injuries in car-to-pedestrian collisions.Pedestrian finite element models are useful tools for studying pedestrian safety, but current models use simplified knee models that exclude potentially important stabilizing knee components.The effect of these stabilizing components in pedestrian impacts is currently unknown.The goal of this study was to develop a detailed lower-extremity model to investigate the effect of these stabilizing components on pedestrian biomechanics.In this study the global human body model consortium male 50th percentile pedestrian model lower body was updated to include various stabilizing knee components, enhance geometric anatomical accuracy of previously modeled soft tissue structures, and update hard and soft tissue material models.The original and updated models were compared across 13 validation tests and the updated model reported significantly (p= 0.01) larger cora scores (0.73 ± 0.15) than the original model (0.56 ± 0.20).To investigate the effect of the new stabilizing knee components the updated model had its stabilizing components severed.The severed and intact models were impacted by the euro ncap suv and family car models at 30 and 40 km/h.The intact and severed models reported nearly identical head impact times, wrap around distances, and lower-extremity injury outcomes in all four impacts, but the stabilizing components reduced the varus knee angle of the secondarily impacted leg by up to 4.9°.The stabilizing components may prevent secondary impacted leg injuries in lower intensity impacts but overall had little effect on pedestrian biomechanical outcomes.

Journal: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine (2022)
Publication types: Journal Article
Flaviaesturariibacter flavus sp. nov., isolated from soil in Jeju Island.

A gram-stain-negative, non-motile and yellow-colored bacterium, designated 17j68-12t, was isolated from soil in jeju island, korea.Phylogenetic analysis based on 16s r rna gene sequences revealed that strain 17j68-12tformed a distinct lineage within the family chitinophagaceae and was mostly related to members of flaviaesturariibacter luteus (97.5%), flaviaesturariibacter amylovorans (96.8%) and flaviaesturariibacter terrae (96.8%).Growth was observed at 18-42 °c (optimum 30 °c) in r2a broth at p h 7.0.The major cellular fatty acids of the strain 17j68-12twere summed feature 3 (c16:1ω6c and/or c16:1ω7c), summed feature 1 (c15:1iso-h and/or c13:03-oh), and iso-c15:0.The predominant respiratory quinones are mk-7 and mk-6.The major polar lipid was identified as phosphatidylethanolamine.Based on biochemical, chemotaxonomic and phylogenetic characteristics, the strain 17j68-12trepresents a novel bacterial species within the family chitinophagaceae, for which the name flaviaesturariibacter flavus sp.Nov.Is proposed.The type strain of flaviaesturariibacter flavus is 17j68-12t(= kctc 62219t= jcm 33179t).

Journal: Archives of microbiology (2020)
Publication types: Journal Article