syedzayyan/paper_mill_benchmark huggingface dataset:
The management of colorectal liver metastases amenable of surgical resection: How to shape treatment strategies according to clinical, radiological, pathological and molecular features.

Metastatic colorectal cancer (m crc) patients have poor chances of long term survival, being < 15% of them still alive after 5 years from diagnosis.Nonetheless, patients with colorectal liver metastases (crlm) may be eligible for metastases resection thus being able to achieve long-term disease remission and survival.The likelihood for patients with crlm of being or becoming eligible for liver metastasectomy is increasing, thanks to the evolution of surgical techniques, the availability of active systemic treatments and the widespread diffusion of experienced multidisciplinary boards to manage these patients.However, disease relapse after liver surgery is common and occurs in two-thirds of resected patients.Therefore, adequate radiological staging and risk stratification is crucial for the optimal selection of patients candidate to surgery in order to maximize the benefit-risk ratio of liver metastasectomy and to individualize the treatment strategy.Based on the multidimensional assessment, three possible approaches are available: upfront liver surgery followed by adjuvant chemotherapy, perioperative chemotherapy preceding and following liver surgery, and an upfront systemic treatment including chemotherapy plus a targeted agent, both chosen according to patients' and tumours' characteristics, then followed by liver surgery if indicated.In this review, we describe the most important factors impacting the therapeutic choices in patients with resectable and potentially resectable crlm, and we discuss the most promising factors that may reshape the future decision-making process of these patients.

Journal: Cancer treatment reviews (2022)
Publication types: Journal Article;Review
Iridium-Catalyzed Reductive Nucleophilic Addition to Secondary Amides.

An iridium-catalyzed reductive nucleophilic addition to secondary amides is reported.After the iridium-catalyzed reduction, the resulting imines can undergo the strecker reaction, the mannich reaction, allylation, and [3 + 2]-cycloaddition.The method shows high chemoselectivity in the presence of other functional groups such as methyl ester.

Journal: Organic letters (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Soil nutrients and plant uptake parameters as related to greenhouse gas emissions.

Fertilizer and water management practices have short- and long-term effects on soil chemical and physical properties and, in turn, greenhouse gas (ghg) emissions.The goal of this 4-yr field study was to establish the relationships between soil properties, agronomic practices, and ghg (co2and n2o) emissions under different fertilizer and water table management practices.There were two fertilizer treatments: inorganic fertilizer (if) and a mix of solid cattle manure and inorganic fertilizer (scm), combined with tile drainage(dr) and controlled drainage with subirrigation(cds).The cropping system was a maize (zea mays l.)-soybean [glycine max (l.) merr.] rotation.Nitrogen in biomass (bmn) and n in grain (grn) were measured and used to calculate other plant n parameters.Nitrous oxide and co2fluxes were collected weekly, and their respective cumulative emissions were calculated.The results show that soil organic matter (om), soil total carbon (c), and soil total nitrogen (n) were greater in scm than if by 23.7, 35.2, and 24.4%, respectively.Water table management did not significantly affect soil n and c.Increased co2emissions were witnessed under higher soil om, soil total c, and total n.Plant n uptake parameters were negatively correlated with n2o and co2emissions.Higher plant n uptake can reduce environmental pollution by limiting n2o and co2emissions.

Journal: Journal of environmental quality (2022)
Publication types: Journal Article
Nurse leaders' perceptions and experiences of leading evidence: A qualitative enquiry.

The aim of this study was to describe nurse leaders' perceptions and experiences of leading evidence-based practices (ebp).Background leaders can promote ebp in nursing with their own personal example and by striving to renew structures, processes and working cultures.However, previous studies have shown that nurse leaders have tended to be passive with regard to ebp.Methods an interview study using general qualitative methods.In total, 33 individual interviews and seven focus groups of leaders were conducted in 2015 and 2017.Data were analysed thematically.Results the respondents were unfamiliar with ebp as activities that lead to effective patient care.Ebp were described as indistinguishable from other practices, lost and random.Overall, they lacked competence with ebp.The activities of nurse leaders do indicate a tentative commitment to ebp, but their main goals seem to be maintaining the status quo.Conclusion unfamiliarity with ebp reflects adversely on the operations of an entire organisation.The nurse leaders have an opportunity to enhance their understanding with ebp, which will lead to the renewal and improvement of the operating culture and the quality of strategic leadership.Implications for nursing management leaders should take clear responsibility for ebp on the strategic, operational and educational level.

Journal: Journal of nursing management (2019)
Publication types: Journal Article
High-pressure behaviour of Prussian blue analogues: interplay of hydration, Jahn-Teller distortions and vacancies.

We report a high-pressure crystallographic study of four hydrated prussian blue analogues: m[pt(cn)6] and m[co(cn)6]0.67(m = mn2+, cu2+) in the range 0-3 gpa.Mn[co(cn)6]0.67was studied by single-crystal x-ray diffraction, whereas the other systems were only available in polycrystalline form.The mn-containing compounds undergo pressure-induced phase transitions from fm3[combining macron]m to r3[combining macron] at ∼1.0-1.5 gpa driven by cooperative tilting of the octahedral units.No phase transition was found for the orbitally disordered cu[co(cn)6]0.67up to 3 gpa.Mn[co(cn)6]0.67is significantly softer than the other samples, with a bulk modulus of ∼14 gpa compared to ∼35 gpa of the powdered samples.The discrepant pressure responses are discussed in terms of the presence of structural defects, jahn-teller distortions, and hydration.The implications for the development of polar systems are reviewed based upon our high-pressure study.

Journal: Dalton transactions (Cambridge, England : 2003) (2019)
Publication types: Journal Article
Recommendations for Cancer Surveillance in Individuals with RASopathies and Other Rare Genetic Conditions with Increased Cancer Risk.

In october 2016, the american association for cancer research held a meeting of international childhood cancer predisposition syndrome experts to evaluate the current knowledge of these syndromes and to propose consensus surveillance recommendations.Herein, we summarize clinical and genetic aspects of rasopathies and sotos, weaver, rubinstein-taybi, schinzel-giedion, and nkx2-1 syndromes as well as specific metabolic disorders known to be associated with increased childhood cancer risk.In addition, the expert panel reviewed whether sufficient data exist to make a recommendation that all patients with these disorders be offered cancer surveillance.For all syndromes, the panel recommends increased awareness and prompt assessment of clinical symptoms.Patients with costello syndrome have the highest cancer risk, and cancer surveillance should be considered.Regular physical examinations and complete blood counts can be performed in infants with noonan syndrome if specific ptpn11or krasmutations are present, and in patients with cbl syndrome.Also, the high brain tumor risk in patients with l-2 hydroxyglutaric aciduria may warrant regular screening with brain mris.For most syndromes, surveillance may be needed for nonmalignant health problems.clin cancer res; 23(12); e83-e90.©2017 aacrsee all articles in the online-only ccrpediatric oncology series.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research (2017)
Publication types: Journal Article;Review
Builder, Expert, Disruptor, Leader: The Many Roles of People with Lived Experience.

People with lived experience of health and social care, including family carers, should be at the heart of integrated care policy and practice.One of the challenges to achieving such co-production is insufficient clarity and limited understanding of the different roles that people with lived experience are asked or choose to undertake.Following research and workshops, four roles have been identified - community builder, improvement expert, disruptor/advocate, and citizen leader.Recognising the distinct contribution and demands of these roles will enable appropriate support and development for people with lived experience and the professionals and managers with whom they collaborate.

Journal: International journal of integrated care (2023)
Publication types: Journal Article
Pyridine-Containing Macrocycles Display MMP-2/9 Inhibitory Activity and Distinct Effects on Migration and Invasion of 2D and 3D Breast Cancer Models.

The role of metalloproteinases (mmps) on the migration and invasion of cancer cells has been correlated with tumor aggressiveness, namely with the up-regulation of mmp-2 and 9.Herein, two pyridine-containing macrocyclic compounds, [15]py n5and [16]py n5, were synthesized, chemically characterized and evaluated as potential mmp inhibitors for breast cancer therapy using 3d and 2d cellular models.[15]py n5and [16]py n5(5-20 μm) showed a marked inhibition of mmps activity (100% at concentrations ≥ 7.5 μm) when compared to arp-100, a known mmp inhibitor.The inhibitory activity of [15]py n5and [16]py n5was further supported through in silico docking studies using goldscore and chem plp scoring functions.Moreover, although no significant differences were observed in the invasion studies in the presence of all mmps inhibitors, cell migration was significantly inhibited by both pyridine-containing macrocycles at concentrations above 5 μm in 2d cells (p< 0.05).In spheroids, the same effect was observed, but only with [16]py n5at 20 μm and arp-100 at 40 μm.Overall, [15]py n5and [16]py n5led to impaired breast cancer cell migration and revealed to be potential inhibitors of mmps 2 and 9.

Journal: International journal of molecular sciences (2019)
Publication types: Journal Article
Two-dimensional beam steering with tunable metasurface in infrared regime.

Tunable metasurfaces can change the optical properties of incident light at will such as amplitude, phase, and polarization in a time-dependent fashion.Ultrafast switching speed and the ability for the pixel size reduction of the tunable metasurface can allow various applications such as light detection and ranging, interferometric sensors, and free space optical communications, to name a few.Although there have been successful demonstrations of the wavefront shaping using the tunable metasurface, the implementation of the two-dimensional metasurface pixel array that can be individually addressed in the optical frequency regime still remains challenging.Here, we present theexperimental demonstrationof the two-dimensional beam steering with the metasurface array by the binary phase grating in the infrared regime.The metasurface unit cell is composed of metal-dielectric-oxide structure with the indium tin oxide as an active layer, which is modulated by using the top fan-out electrodes.The metasurface array is two-dimensionally pixelated and has the phase change above 137° in the infrared regime.

Journal: Nanophotonics (Berlin, Germany) (2022)
Publication types: Journal Article
A Triplex PCR Method for Distinguishing the Wild-Type African Swine Fever Virus From the Deletion Strains by Detecting the Gene Insertion.

To date, there is no effective vaccine or antiviral therapy available to prevent or treat african swine fever virus (asfv) infections.Asfv gene deletion strains have been proposed as promising anti-asfv vaccine candidates.In recent years, most asfv gene deletion strains worldwide have been recombinant strains expressing egfporm cherryas markers.Therefore, in this study, a new triplex real-time pcr (rt-pcr) method was established for the broad and accurate differentiation of asfv wild-typevs.Gene deletion strains.We designed three pairs of primers and probes to target b646l, egfp, andm cherry, and rt-pcr was used to detect these three genes simultaneously.The detection method prevented non-specific amplification of porcine reproductive and respiratory syndrome virus, porcine epidemic diarrhea virus, circovirus type 2, pseudorabies virus, and classical swine fever virus genes.The minimum copy number of standard plasmid dna detected using triplex rt-pcr was 9.49, 15.60, and 9.60 copies for b646l, egfp, andm cherry, respectively.Importantly, of the 1646 samples analyzed in this study, 67 were positive for asfv, all corresponding to the wild-type virus.Overall, our data show that the triplex rt-pcr method established in this study can specifically identify both asfv wild-type and gene deletion strains.

Journal: Frontiers in veterinary science (2022)
Publication types: Journal Article
Gender differences in patients with severe dental infections presenting to hospital.

Introduction gender differences have been documented in prevalence and morbidity of caries, gingivitis and oral health, but not previously in cervicofacial infection.Identification and minimisation of gender inequalities is a world health organisation priority, and there are physiological, behavioural and cultural reasons to suspect that sex and gender differences may be present.methods analysis was carried out of the mtre c national snapshot audit of cervicofacial infections.This database was created by oral and maxillofacial surgery trainees in 2017 and records over 400 variables in 1,002 individual patients admitted to hospital with severe odontogenic infection.results records were available for 1,002 patients with cervicofacial infection (456 females and 546 males).There were significant differences between recorded gender in those presenting with airway compromise (male 7% vs female 2%, p = 0.001), severe inflammatory response syndrome (male 60% vs female 39%, p = 0.007) and requirement for awake fibre-optic intubation on admission (male 4% vs female 1%, p = 0.014).discussion these results suggest that male patients access healthcare later in their disease than female patients, and with more severe systemic compromise.This may be due to prevalent cultural and behavioural norms.As equality of access is the responsibility of the administrator, we discuss methods which might improve timely presentation in males with cervicofacial infections.

Journal: British dental journal (2021)
Publication types: Journal Article
Same-Day Patient Consultation and Cochlear Implantation: Patient Experiences and Barriers to Implementation.

This study aimed to assess the efficacy of same-day cochlear implant (sdci) evaluation and surgery in improving patient experience.Patients adult ci candidates participated in this study.Interventions education materials and communication with providers were offered via telephone, e-mail, and/or telemedicine.Patients then arrived for in-person consultation, imaging studies, and outpatient ci surgery in one visit and received a 3-month postoperative survey.Main outcome measures preoperative hearing, referral-to-surgery time, travel burden, and patient satisfaction were included as outcome measures.Results of 35 patients who qualified, 14 were successfully contacted regarding the same-day program: 9 underwent ci, 1 enrolled but did not ultimately meet candidacy criteria, and 4 declined because of coronavirus and/or active medical conditions and did not pursue a ci.For the nine patients who underwent sdci, mean age was 78 years, and mean preoperative consonant-nucleus-consonant score was 16% in the implanted ear.Mean referral-to-surgery time was 103 days and, after accounting for cancellations because of coronavirus, was 52 days.Mean travel distance to institution was 234 miles.Of the seven patients who completed the follow-up survey, none felt rushed for surgery, and mean program experience was rated 8.6 out of 10.Net promoter score was positive (+72), supporting high experience favorability among patients.Barriers to program expansion included patient recruitment and education, surgery scheduling, and the coronavirus pandemic.Conclusions no patients declined the sdci program to pursue traditional ci evaluation, and all patients were satisfied with their experience.The sdci program is a feasible and successful model that overcomes barriers to implantation, including travel burden, and improves access to care.

Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology (2022)
Publication types: Journal Article
Beneficial Effects of Milk-Derived Extracellular Vesicles on Liver Fibrosis Progression by Inhibiting Hepatic Stellate Cell Activation.

Liver fibrosis is the consequence of various chronic liver diseases, resulting in accumulation of extracellular matrix, following the activation and proliferation of hepatic stellate cells (hscs).Based on the milk-derived extracellular vesicles' (mdes') characteristics and biological proprieties, we investigate whether mdes may regulate fibrotic progression by inhibiting hscs' activation via the mdes' mi rna content.In order to study this question, we examined the effect of human and cow mdes on hscs isolated from murine livers, on activation, proliferation and their proteins' expression.We have shown that mdes are able to enter into hscs in vitro and into the livers in vivo.Mdes inhibited hscs' proliferation following stimulation with pdgf.Moreover, in vivo treatment with mdes resulted in an increase of in mi rna-148 and let7a expression in hscs.In contrast, treatment with mdes reduced the expression of mi r-21 in hscs.In addition, mdes regulate hsc activation, as was shown by downregulation of collagen i expression and alpha smooth muscle actin, and upregulation of pparγ.Mdes carrying beneficial mi rnas can be a nontoxic natural target for treatment of liver cirrhosis.

Journal: Nutrients (2022)
Publication types: Journal Article
Estimating the Economic and Clinical Value of Introducing Ceftazidime/Avibactam into Antimicrobial Practice in Japan: A Dynamic Modelling Study.

Antimicrobial resistance (amr) is one of the most serious public health challenges worldwide, including in japan.Globally, research and development of new antimicrobials has stalled due to unfavorable market conditions, which undervalue antimicrobials.Furthermore, japan faces the additional challenge of delayed commercialization for a number of recently approved treatments.Objective this study aims to examine the impact on amr of introducing a new anti-infective treatment, ceftazidime/avibactam, into current treatment strategies.It reports the resulting clinical and economic outcomes from the perspective of healthcare payers in japan.Methods a previously published and validated dynamic disease transmission model was adapted to the japanese setting.The model estimated health economic outcomes for treating three gram-negative hospital-acquired infections, under different treatment strategies, from a healthcare payers' perspective.Outcomes were assessed over a 10-year time horizon with a willingness-to-pay threshold of ¥5,000,000 (us$45,556) per quality-adjusted life-year (qaly) gained and an annual discount rate of 2% applied to costs and benefits.Results introducing ceftazidime/avibactam in the framework of a diversification strategy with piperacillin/tazobactam is associated with reducing 798,640 bed days, equating to ¥21.0 billion (us$190.9 million) savings in hospitalization costs, and a gain of 363,034 life-years, or 308,641 qalys.This translates into a monetary benefit of ¥1.56 trillion (us$14.3 billion) to japanese healthcare payers.Discussion introducing a new antimicrobial agent into clinical practice is associated with considerable clinical and economic benefits.This analysis demonstrates that the approach taken to incorporate a new antimicrobial agent into clinical practice impacts on the scale of these clinical and economic benefits; greater benefits are associated with earlier use of antimicrobials as part of an antimicrobial stewardship program.Conclusion this analysis shows that changing the way in which a new antimicrobial is used within a treatment strategy has the potential for additional significant clinical and economic value.

Journal: PharmacoEconomics - open (2023)
Publication types: Journal Article
A New Pathogenic Missense Variant in a Consanguineous North-African Family Responsible for a Highly Variable Aceruloplasminemia Phenotype: A Case-Report.

Aceruloplasminemia is a rare autosomal recessive inherited disorder.Mutations in the ceruloplasmin gene cause depressed ferroxidase activity leading to iron accumulation.The clinical phenotype is highly variable: anemia, retinopathy, diabetes mellitus, psychiatric disorders, and neurological symptoms including parkinsonian disorders and dementia are the main features of this disease.Characterized by high serum ferritin with low transferrin saturation, aceruloplasminemia uniquely combines brain, liver and systemic iron overload.We report here four new cases of aceruloplasminemia in a consanguineous north-african family.Genetic sequencing revealed a homozygous missense variant c.656t>a in exon 4 of the ceruloplasmin gene, which had been described previously as of "unknown significance" in the db snp database and never associated with acp in the hgmd database.Ferroxidase activity was strongly depressed.Clinical manifestations varied among cases.The proband exhibited mild microcytic anemia, diabetes mellitus, psychosis and parkinsonism, whereas the other cases were asymptomatic or mildly anemic, although high serum ferritin and brain iron deposition were documented in all of them.Therapeutic management was complex.The proband started deferoxamine treatment when already symptomatic and he rapidly declined.In the asymptomatic cases, the treatment was associated with poor tolerance and was discontinued due to anemia requiring red blood cell transfusion.Our series illustrates the need for new therapeutic approaches to aceruloplasminemia.

Journal: Frontiers in neuroscience (2022)
Publication types: Case Reports;Journal Article
Bezold's Abscess: A Case Report and Review of Cases Over 20 Years.

Bezold's abscess (ba) is a severe and rare extracranial complication of suppurative acute mastoiditis.The diagnosis of ba requires a high index of suspicion due to its rarity.In this study, we present a rare case of ba, in addition to a review of literature over 20 years.We searched for all cases in english literature from 2000 to 2020 in pub med and found 27 cases (28 cases including the current case).Ba was more prevalent in males (17/28, 60.7%) and adults (17/28, 60.7%).Of the 28 cases, six were associated with cholesteatoma and another six cases occurred with concomitant sinus thrombosis.

Journal: Cureus (2022)
Publication types: Case Reports;Journal Article