syedzayyan/paper_mill_benchmark huggingface dataset:
Molecular insights and therapeutic implications of nanoengineered dietary polyphenols for targeting lung carcinoma: part I.

Lung cancer is the second leading cause of cancer-related mortality globally, and non-small-cell lung cancer accounts for most lung cancer cases.Nanotechnology-based drug-delivery systems have exhibited immense potential in lung cancer therapy due to their fascinating physicochemical characteristics,in vivostability, bioavailability, prolonged and targeted delivery, gastrointestinal absorption and therapeutic efficiency of their numerous chemotherapeutic agents.However, traditional chemotherapeutics have systemic toxicity issues; therefore, dietary polyphenols might potentially replace them in lung cancer treatment.Polyphenol-based targeted nanotherapeutics have demonstrated interaction with a multitude of protein targets and cellular signaling pathways that affect major cellular processes.This review summarizes the various molecular mechanisms and targeted therapeutic potentials of nanoengineered dietary polyphenols in the effective management of lung cancer.

Journal: Nanomedicine (London, England) (2022)
Publication types: Journal Article;Review
Comparison of Serum Nucleosomes and Tissue Inhibitor of Metalloproteinase1 (TIMP1) in Predicting Mortality in Adult Critically Ill Patients in Sepsis: Prospective Observational Study.

Sepsis is a life-threatening organ dysfunction due to dysregulated host response to infection.Timely identification is important for risk reduction and better outcomes in critically ill patients.Nucleosomes and tissue inhibitors of metalloproteinase1 (timp1) are the biomarkers whose validity and utility in predicting organ dysfunction and mortality in sepsis have been proven.However, which biomarker among these two has better predictive value in elucidating disease severity, organ dysfunction, and mortality in sepsis is yet to be answered, and further studies are needed.Methods eighty patients with sepsis/septic shock, aged between 18 and 75 years admitted in intensive care unit (icu) were recruited in this prospective observational trial.Quantification of serum nucleosomes and timp1 was done using enzyme linked immunosorbent assay (elisa) within 24 hours of diagnosis of sepsis/septic shock.The primary outcome was to compare the predictability of nucleosomes and timp1 in estimating sepsis mortality.Results the area under the receiver operating characteristic curve (auroc) for timp1 and nucleosomes to discriminate between survivors and non-survivors were 0.70 [95% confidence interval (ci), 0.58-0.81] and 0.68 (0.56-0.80), respectively.Although independent, timp1 and nucleosomes have statistically significant capacity to discriminate between survivors and non-survivors (p= 0.002 andp= 0.004, respectively), superiority of one biomarker over the other in discriminating between survivors and non-survivors was not observed.Conclusion the median values of each biomarker showed statistically significant differences between survivors and non-survivors, superiority of one biomarker over other in predicting mortality was not observed.However, this was an observational study and larger studies are needed in the future to validate the findings of this study.How to cite this article rai n, khanna p, kashyap s, kashyap l, anand rk, kumar s.Comparison of serum nucleosomes and tissue inhibitor of metalloproteinase1 (timp1) in predicting mortality in adult critically ill patients in sepsis: prospective observational study.Indian j crit care med 2022;26(7):804-810.

Journal: Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine (2022)
Publication types: Journal Article
Laparoscopic versus open approach in gastrectomy for advanced gastric cancer: a systematic review.

Additional studies comparing laparoscopic gastrectomy (lg) versus open gastrectomy (og) for advanced gastric cancer (agc) have been published, and it is necessary to update the systematic review of this subject.Objective we conducted the meta-analysis to find some proof for the use of lg in agc and evaluate whether lg is an alternative treatment for agc.Method randomized controlled trials (rct) and high-quality retrospective studies (nrct) compared lg and og for agc, which were published in english between january 2010 and may 2019, were search in pub med, embase, and web of knowledge by three authors independently and thoroughly.Some primary endpoints were compared between the two groups, including intraoperative time, intraoperative blood loss, harvested lymph nodes, first flatus, first oral intake, first out of bed, post-operative hospital stay, postoperative morbidity and mortality, rate of disease recurrence, and 5-year over survival (5-y os).Besides, considering for this 10-year dramatical surgical material development between 2010 and 2019, we furtherly make the same analysis based on recent studies published between 2016 and 2019.Result thirty-six studies were enrolled in this systematic review and meta-analysis, including 5714 cases in lag and 6094 cases in og.Lg showed longer intraoperative time, less intraoperative blood loss, and quicker recovery after operations.The number of harvested lymph nodes, hospital mortality, and tumor recurrence were similar.Postoperative morbidity and 5-y os favored lg.Furthermore, the systemic analysis of recent studies published between 2016 and 2019 revealed similar result.Conclusion a positive trend was indicated towards lg.Lg can be performed as an alternative to og for agc.

Journal: World journal of surgical oncology (2020)
Publication types: Comparative Study;Journal Article;Meta-Analysis;Systematic Review
Title: advancing urban health equity in the United States in an age of health care gentrification: a framework and research agenda.

Access to health care has traditionally been conceptualized as a function of patient socio-demographic characteristics (i.e., age, race/ethnicity, education, health insurance status, etc.) and/or the system itself (i.e., payment structures, facility locations, etc.).However, these frameworks typically do not take into account the broader, dynamic context in which individuals live and in which health care systems function.Purpose the growth in market-driven health care in the u.s.Alongside policies aimed at improving health care delivery and quality have spurred health system mergers and consolidations, a shift toward outpatient care, an increase in for-profit care, and the closure of less profitable facilities.These shifts in the type, location and delivery of health care services may provide increased access for some urban residents while excluding others, a phenomenon we term "health care gentrification." in this commentary, we frame access to health care in the united states in the context of neighborhood gentrification and a concurrent process of changes to the health care system itself.Conclusions we describe the concept of health care gentrification, and the complex ways in which both neighborhood gentrification and health care gentrification may lead to inequitable access to health care.We then present a framework for understanding health care gentrification as a function of dynamic and multi-level systems, and propose ways to build on existing models of health care access and social determinants of health to more effectively measure and address this phenomenon.Finally, we describe potential strategies applied researchers might investigate that could prevent or remediate the effects of health care gentrification in the united states.

Journal: International journal for equity in health (2022)
Publication types: Letter;Research Support, Non-U.S. Gov't
Standardized EEG interpretation in patients after cardiac arrest: Correlation with other prognostic predictors.

Introduction standardized eeg patterns according to the american clinical neurophysiology society (acns) ("highly malignant", "malignant" and "benign") demonstrated good correlation with outcome after cardiac arrest (ca).However, this approach relates to eegs after target temperature management (ttm), and correlation to other recognized outcome predictors remains unknown.Objectives to investigate the relationship between categorized eeg and other outcome predictors, during and after ttm, at different temperatures.Methods in a prospective adult ca registry between 01.2014 and 06.2017, eeg at day one and two after ca were reclassified into pre-defined categories.Correlations between eeg and clinical, biochemical, neurophysiological outcome predictors, and prognosis (cpc at three months; good: 1-2), were assessed.Results of 203 ca episodes, 31.5% were managed targeting 33 °c, 60.6% targeting 36 °c, and 7.9% with spontaneous temperature."highly malignant" eeg was found in 36.7% of patients at day one (predicting poor prognosis with 91% specificity -95%ci: 83%-97%-, and 63% sensitivity -95% ci: 53%-72%), and 27.1% at day two."benign" eeg occurred in 19.2% at day one (sensitivity to good prognosis: 35% -95%ci: 26%-46%-, positive predictive value: 89% -95% ci: 75%-97%), and in 33.2% at day two.Categorized eeg showed robust correlations with all prognostic predictors.Results were similar between eegs recorded at day one or two, and, especially for poor prognosis, across ttm targets.Discussion standardized eeg categorization after ca shows strong correlation with other outcome predictors, without marked variation across eeg recording time or ttm targets, underscoring its prognostic role in a multimodal approach.

Journal: Resuscitation (2018)
Publication types: Journal Article
Unmet needs of 1210 Chinese breast cancer survivors and associated factors: a multicentre cross-sectional study.

Breast cancer survivors (bcss) often have potential unmet needs.Identification of the specific needs of bcss is very significant for medical service provision.This study aimed to (1) investigate the unmet needs and quality of life (qo l) of bcss in china, (2) explore the diverse factors associated with their unmet needs, and (3) assess the association between their unmet needs and qo l.Methods a multicentre, cross-sectional survey was administered to 1210 chinese bcss.The cancer survivor profile-breast cancer and the functional assessment of cancer therapy-breast scale were administered to survivors who gave informed consent to participate.Data were analysed using t-test, anova, multiple regression analysis, and pearson correlations.Results the 1192 participants completed questionnaires (response rate 98.51%).Our study reveals that the most prevalent unmet needs were in the 'symptom burden domain'.The unmet needs of bcss depend on eleven factors; age, time since diagnosis, education level, occupation, payment, family income status, stage of cancer, treatment, family history of cancer, pain, and physical activities.To ensure the provision of high-quality survivorship care and a high satisfaction level, more attention should be paid to actively identifying and addressing the unmet needs of bcss.The problem areas identified in the cancer survivor profile for breast cancer were negatively associated with all subscales of qo l except the health behaviour domain, with the correlation coefficient ranging from - 0.815 to - 0.011.Conclusion chinese bcss exhibit a high demand for unmet needs in this study, and the most prevalent unmet needs were in the 'symptom burden domain'.There was a significant association between patients' unmet needs (as defined in the cancer survivor profile for breast cancer) and qo l.Future research should focus on enhancements to survivorship or follow-up care to address unmet needs and further improve qo l.

Journal: BMC cancer (2022)
Publication types: Journal Article;Multicenter Study
Decreased Sirt3 contributes to cyclic production of reactive oxygen species and islet β-cell apoptosis in high glucose conditions.

Reactive oxygen species (ros) plays a vital role in the apoptosis of islet β-cells in type 2 diabetes mellitus (t2dm).Sirt3 (sirtuin 3, a deacetylase) and fox o1 (a transcription factor) might be involved in ros production.This study was to investigate mechanism of ros production and β-cell apoptosis in t2dm.Methods oxidative stress and apoptosis in islets of db/db mice and high glucose cultured β-cells were observed by terminal deoxynucleotidyl transferase-mediated nick end labeling (tunel) assay and western blotting.Then, h2o2was used to ascertain the effect of ros on the expression of sirt3.Meanwhile, fox o1, antioxidant enzymes - catalase (cat) and manganese superoxide dismutase (mn sod) and β-cell apoptosis were also determined by western blotting.Finally, sirt3 was knocked down to evaluate the effect on oxidative stress and apoptosis of β-cells.Results under high glucose environment, enhanced ros made a decrease of sirt3 expression, which increased acetylation of fox o1, thus reduced the expression of its target proteins -mn sod and cat, and further significantly increased ros levels.Increased ros finally led to the apoptosis of β-cells.Conclusion down-regulation of sirt3 plays an important role in the cyclic production of ros and β-cell apoptosis.Targeting sirt3 may be favorable for the treatment of t2dm.

Journal: Molecular biology reports (2022)
Publication types: Journal Article
Gene therapy for hemophilia.

Gene therapy offers the potential for a cure for patients with hemophilia by establishing continuous endogenous expression of factor viii or factor ix (fix) following transfer of a functional gene to replace the hemophilic patient's own defective gene.The hemophilias are ideally suited for gene therapy because a small increment in blood factor levels (≥5% of normal) is associated with significant amelioration of bleeding phenotype in severely affected patients.In 2011, the st.Jude/ucl phase 1/2 trial was the first to provide clear evidence of a stable dose-dependent increase in fix levels in patients with severe hemophilia b following a single administration of adeno-associated viral (aav) vectors.Transgenic fix expression has remained stable at ∼5% of normal in the high-dose cohort over a 7-year follow-up period, resulting in a substantial reduction in spontaneous bleeding and fix protein usage without toxicity.This study has been followed by unparalleled advances in gene therapy for hemophilia a and b, leading to clotting factor activity approaching normal or near-normal levels associated with a "zero bleed rates" in previously severely affected patients following a single administration of aav vectors.Thus, aav gene therapies are likely to alter the treatment paradigm for hemophilia a and b.This review explores recent progress and the remaining limitations that need to be overcome for wider availability of this novel treatment of inherited bleeding disorders.

Journal: Hematology. American Society of Hematology. Education Program (2019)
Publication types: Journal Article;Review
Kinetic Modeling and Degradation Study of Liquid Polysulfide Resin-Clay Nanocomposite.

Kinetic modeling and degradation study of liquid polysulfide (lps)/clay nanocomposite is possible through ozawa-flynn-wall (ofw) and kissinger methods.Comparing the results of these models with experimental data leads to provide an accurate degradation kinetic evaluation of these materials.To this aim, the morphology and distribution of clay nanoparticles (cnps) within the lps matrix were investigated using field emission scanning electron microscopy (fesem) and x-ray diffraction (xrd).To evaluate the interaction between the lps and the cnps, the fourier transform infrared (ftir) identification was utilized.Furthermore, to investigate the kinetics of degradation, the thermal gravimetric analysis (tga) and derivative thermogravimetry (dtg) of the samples were used in the nitrogen atmosphere with the help of kissinger and ozawa-flynn-wall (ofw) models.The characterization results confirmed the homogenous dispersion of the cnps into the lps matrix.In addition, the presence of cnps increased the thermal stability and activation energy (ea) of the samples at different conversion rates.Moreover, the ofw method was highly consistent with the experimental data and provided an appropriate fit for the degradation kinetics.

Journal: Molecules (Basel, Switzerland) (2021)
Publication types: Journal Article
Generation of three iPSC lines from fibroblasts of a patient with Aicardi Goutières Syndrome mutated in TREX1.

Fibroblasts from a patient with aicardi goutières syndrome (ags) carrying a compound heterozygous mutation in trex1, were reprogrammed into induced pluripotent stem cells (i pscs) to establish isogenic clonal stem cell lines: unibsi006-a, unibsi006-b, and unibsi006-c.Cells were transduced using the episomal sendai viral vectors, containing human oct4, sox2, c-myc and klf4 transcription factors.The transgene-free i psc lines showed normal karyotype, expressed pluripotent markers and displayed in vitro differentiation potential toward cells of the three embryonic germ layers.

Journal: Stem cell research (2019)
Publication types: Case Reports;Journal Article;Research Support, Non-U.S. Gov't
Therapeutic priorities for solitary large hepatocellular carcinoma in a hepatitis B virus endemic area; an analysis of a nationwide cancer registry database.

We compared overall survival (os) of patients with a solitary large (>5 cm) hepatocellular carcinoma (hcc) treated surgically or by transarterial chemoembolization (tace).Methods the archived records of hcc patients registered at the korean central cancer registry from 2003 through 2005 (registry a, n = 4 520) or from 2008 through 2010 (registry b, n = 4 596) were retrospectively analyzed.In these registries, 578 and 315 patients had a single large hcc, respectively.In registry a, 442 (cohort a) underwent surgery (n = 96) or tace (n = 346).In registry b, 253 (cohort b) underwent surgery (n = 110) or tace (n = 143).Cohort c (n = 695) was constructed by combining cohorts a and b, and thus, 206 and 489 patients received surgery and tace, respectively.Results in cohort c, cumulative os rates at 1-, 3-, and 5-years were significantly higher for surgery than tace (89.3%, 67.4%, and 58.0% vs 67.7%, 38.2%, and 27.2%, respectively, p < 0.001).Similar results were obtained for cohorts a and b, even after propensity-score matching in three cohorts (p values for all <0.05).Tace (hr 2.18, p < 0.001), serum albumin (hr 0.77, p = 0.015), and tumor size (hr 1.06, p < 0.001) were predictors of post-treatment mortality.Conclusions surgery is associated with improved os for a solitary large hcc of bclc stage a.

Journal: Journal of surgical oncology (2017)
Publication types: Journal Article
The neurostructural and neurocognitive effects of physical activity: A potential benefit to promote eating disorder recovery.

Accumulating evidence suggests that supervised and adapted physical activity provides cognitive benefits for individuals with eating disorders (eds).The mechanisms underlying the benefits of physical activity are poorly understood.Addressing this knowledge gap may inform the appropriate integration of structured physical activity into eating disorders treatment and recovery.We draw attention to recent findings in the study of the impact of physical activity on the brain, and we describe the neurostructural and neurocognitive changes associated with physical activity observed in various clinical and nonclinical populations.Considering the identified impairment in brain volume- and/or neurocognitive function in various eds, we propose that positive effects of physical activity may play a meaningful role in successful ed treatment.Accordingly, we outline research steps for closing the knowledge gap on how physical activity may aid in ed recovery, and emphasize the need to combine measures of cognitive and behavioral responses to physical activity, with technology capable of measuring changes in brain structure and/or function.

Journal: The International journal of eating disorders (2021)
Publication types: Journal Article
CD37 expression in follicular lymphoma.

Cd37 is a tetraspanin protein expressed in various b-cell lymphomas that mediates tumor survival signaling.Follicular lymphoma (fl) is a representative b-cell neoplasm composed of germinal center b cells.In recent years, cd37 has been focused on as a therapeutic target for b-cell lymphoma.The purpose of this study was to characterize cd37 expression in fl patients to identify risk factors associated with various prognostic factors.We retrospectively reviewed 167 cases of fl and evaluated the immunohistochemical expression of cd37 and its statistical association with clinicopathological features.Immunohistochemically, cd37 was observed in the cytoplasm and/or membrane of neoplastic cells, mainly in neoplastic follicles to various extents.One hundred cases (100/167, 60.0%) were categorized as cd37-positive, and 67 cases were cd37-negative.In cases with high follicular lymphoma international prognostic index (flipi), cd37-negative cases had a poor overall survival compared with cd37-positive cases (p = 0.047), although no significant differences were observed in other clinicopathologic factors, including histological grade, bcl2-igh translocation, and immunohistochemical phenotype.Therefore, cd37 protein may play a role in tumor progression and may serve as a therapeutic target.However, further studies are needed to explore its significance.

Journal: Annals of hematology (2022)
Publication types: Journal Article
Resistance mechanisms to HER2-targeted therapy in gastroesophageal adenocarcinoma: A systematic review.

Introduction despite promising results following targeted treatment with human epidermal growth factor receptor 2 (her2)-inhibitors in her2-positive gastric and esophageal adenocarcinoma (gea), prognosis remains dismal.Many patients ultimately demonstrate progression following treatment due to resistance to her2-targeted therapy.Here, we describe the potential primary and secondary resistance mechanisms to her2-targeted therapy in gea.Methods we systematically searched pub med/medline, embase, and central for eligible studies describing changes that were associated with drug resistance.Study quality was assessed using an adjusted version of the ohat risk of bias tool.Quality of proposed resistance mechanisms was assessed using predefined criteria.Results in total, 913 records were screened, of which 73 were included that investigated mechanisms of resistance against anti-her2 treatment in cell lines, xenograft models, patient tissue samples, and publicly available datasets.Her2-targeted therapy resistance was found to be caused by her2 receptor changes, upregulation of compensatory receptors, (re)activation of downstream signaling pathways like pi3k/akt and mapk, epithelial-to-mesenchymal transition, acquirement of stem cell-like properties, alterations in cell cycle related genes, cellular metabolism, and drug pharmacokinetics.Discussion several different mechanisms can contribute to drug resistance to anti-her2 treatment in gea, mainly through loss of or mutations in the her2 receptor and upregulation of alternative receptors such as met, her3, and fgfrs.Despite these preclinical results, methods to overcome the proposed resistance mechanisms in the clinical setting are lacking.Therefore, further investigation of therapy resistance in gea patients treated with her2 targeted therapy is essential to overcome resistance and improve treatment outcome of these patients.

Journal: Cancer treatment reviews (2022)
Publication types: Journal Article;Review;Systematic Review