syedzayyan/paper_mill_benchmark huggingface dataset:
Broad-range 16 s rDNA PCR in synovial fluid does not improve the diagnostic performance of septic arthritis in native joints in adults: cross-sectional single-center study in 95 patients.

To evaluate the diagnostic performance of bacterial identification by broad-range polymerase chain reaction (pcr) of ribosomal dna (r dna) 16 s (16s r dna pcr) for the diagnosis of septic arthritis on native joints.Methods patients with acute mono or oligoarthritis who underwent synovial fluid puncture and prospective follow-up allowing definitive diagnosis (septic arthritis, crystal related disease, chronic inflammatory arthritis, undifferentiated arthritis) were recruited in this single-center study.Systematic analysis of synovial fluid included leukocytes count, search for urate and pyrophosphate crystals with polarized light microscopy, direct bacteriological examination (gram staining), bacteriological culture, and 16s r dna pcr.Results ninety-five patients were included, 34 of which (35.8%) had septic arthritis.Nineteen (20.0%) patients had received probabilistic antibiotic therapy prior to joint puncture.Gram + cocci infection accounted for 79.4% of septic arthritis, of which nearly half (47.1%) was caused by staphylococcus aureus.Eight (23.5%) septic arthritis patients had a 16s r dna pcr positive in the synovial fluid with an auc of 0.618 (95% ci, 0.493-0.742), a sensitivity of 0.24 (95% ci, 0.12-0.40), and a specificity of 1.00 (95% ci 0.94-1.00).The diagnostic performance of 16s r dna pcr was lower than that of direct examination (auc at 0.691, ci 95%, 0.570-0.812), blood cultures (auc at 0.727, ci 95%, 0.610-0.844), and culture (0.925, ci 95%, 0.856-0.994) for the diagnosis of septic arthritis.There was no difference in the positivity of 16s r dna pcr according to previous exposure to antibiotics.Conclusions 16 s r dna pcr in the synovial fluid does not improve the diagnostic performance of septic arthritis on native adult joints, particularly for gram-positive cocci infections.

Journal: Clinical rheumatology (2019)
Publication types: Journal Article
Memory shapes visual search strategies in large-scale environments.

Search is a central visual function.Most of what is known about search derives from experiments where subjects view 2d displays on computer monitors.In the natural world, however, search involves movement of the body in large-scale spatial contexts, and it is unclear how this might affect search strategies.In this experiment, we explore the nature of memory representations developed when searching in an immersive virtual environment.By manipulating target location, we demonstrate that search depends on episodic spatial memory as well as learnt spatial priors.Subjects rapidly learned the large-scale structure of the space, with shorter paths and less head rotation to find targets.These results suggest that spatial memory of the global structure allows a search strategy that involves efficient attention allocation based on the relevance of scene regions.Thus spatial memory may allow less energetically costly search strategies.

Journal: Scientific reports (2018)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis.

Peroxisome proliferator-activator receptors α/δ (pparα/δ) are regarded as potential therapeutic targets for nonalcoholic steatohepatitis (nash).However, pparα/δ dual agonist gft-505exhibited poor anti-nash effects in a phase iii clinical trial, probably due to its weak pparα/δ agonistic activity and poor metabolic stability.Other reported pparα/δ dual agonists either exhibited limited potency or had unbalanced pparα/δ agonistic activity.Herein, we report a series of novel triazolone derivatives as pparα/δ dual agonists.Among them, compound h11exhibited potent and well-balanced pparα/δ agonistic activity (pparα ec50= 7.0 n m; pparδ ec50= 8.4 n m) and a high selectivity over pparγ (pparγ ec50= 1316.1 n m) in ppar transactivation assays.The crystal structure of pparδ in complex with h11revealed a unique pparδ-agonist interaction.h11, which had excellent pk properties and a good safety profile, showed potent in vivo anti-nash effects in preclinical models.Together,h11holds a great promise for treating nash or other inflammatory and fibrotic diseases.

Journal: Journal of medicinal chemistry (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Management of Neglected Patellar Tendon Rupture via the Ilizarov Apparatus and Patellar Transport Following Multistage Reconstruction using Contralateral Patella Tendon Bone Autograft: A Case Study.

Muscle elongation by ilizarov apparatus is one of the most remarkable surgeries performed to date.Chronic patella tendon injury is an uncommon condition, and due to its rarity, it is difficult to operate and restore the quality of life and function of the patient.Here we demonstrated a 40-year-old saudi person who underwent a three-stage operative procedure on him: in the first stage we entailed debridement and removal of the implant; in the second stage, we performed this innovative ilizarov muscle elongation of the quadriceps, and in the third stage, we reconstructed the right patellar tendon using a contralateral patella tendon bone autograft fixed by 3.5 screws proximal to the patella and distal to the tibial tuberosity and augmented by cerclage wires.After 3 months of intensive physical therapy, the patient regained his knee's range of motion and muscle strength and was able to return to his security job.Graphical abstract supplementary information the online version contains supplementary material available at .

Journal: Indian journal of orthopaedics (2022)
Publication types: Case Reports;Journal Article
A heterogeneous network-based method with attentive meta-path extraction for predicting drug-target interactions.

Predicting drug-target interactions (dtis) is crucial at many phases of drug discovery and repositioning.Many computational methods based on heterogeneous networks (hns) have proved their potential to predict dtis by capturing extensive biological knowledge and semantic information from meta-paths.However, existing methods manually customize meta-paths, which is overly dependent on some specific expertise.Such strategy heavily limits the scalability and flexibility of these models, and even affects their predictive performance.To alleviate this limitation, we propose a novel hn-based method with attentive meta-path extraction for dti prediction, named hamp dti, which is capable of automatically extracting useful meta-paths through a learnable attention mechanism instead of pre-definition based on domain knowledge.Specifically, by scoring multi-hop connections across various relations in the hn with each relation assigned an attention weight, hamp dti constructs a new trainable graph structure, called meta-path graph.Such meta-path graph implicitly measures the importance of every possible meta-path between drugs and targets.To enable hamp dti to extract more diverse meta-paths, we adopt a multi-channel mechanism to generate multiple meta-path graphs.Then, a graph neural network is deployed on the generated meta-path graphs to yield the multi-channel embeddings of drugs and targets.Finally, hamp dti fuses all embeddings from different channels for predicting dtis.The meta-path graphs are optimized along with the model training such that hamp dti can adaptively extract valuable meta-paths for dti prediction.The experiments on benchmark datasets not only show the superiority of hamp dti in dti prediction over several baseline methods, but also, more importantly, demonstrate the effectiveness of the model discovering important meta-paths.

Journal: Briefings in bioinformatics (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Green banana biomass (Musa spp.) as a natural food additive in artisanal tomato sauce.

This study aimed to prepare artisanal tomato sauce (tsc, control) containing 10% (ts10) or 20% (ts20) of whole green banana biomass (gbb).Tomato sauce formulations were evaluated for storage stability, sensory acceptability, and color and sensory parameters correlations.Data were subjected to analysis of variance, followed by the comparison of means by tukey's test (p 0.05) for the interaction between storage time and gbb addition on all physicochemical parameters.Gbb reduced titratable acidity and total soluble solids (p < 0.05), possibly because of its high content of complex carbohydrates.All tomato sauce formulations had adequate microbiological quality for human consumption after preparation.Sauce consistency increased with increasing gbb concentrations, improving the sensory acceptance of this attribute.All formulations achieved the minimum threshold for overall acceptability (70%).A thickening effect was observed with the addition of 20% gbb, resulting in significantly (p < 0.05) higher body, higher consistency, and reduced syneresis.Ts20was described as firm, very consistent, light orange in color, and very smooth.The results support the potential of whole gbb as a natural food additive.

Journal: Food research international (Ottawa, Ont.) (2023)
Publication types: Journal Article
Detecting Aggressive Papillary Thyroid Carcinoma Using Hyperspectral Imaging and Radiomic Features.

Hyperspectral imaging (hsi) and radiomics have the potential to improve the accuracy of tumor malignancy prediction and assessment.In this work, we extracted radiomic features of fresh surgical papillary thyroid carcinoma (ptc) specimen that were imaged with hsi.A total of 107 unique radiomic features were extracted.This study includes 72ex-vivotissue specimens from 44 patients with pathology-confirmed ptc.With the dilated hyperspectral images, the shape feature of least axis length was able to predict the tumor aggressiveness with a high accuracy.The hsi-based radiomic method may provide a useful tool to aid oncologists in determining tumors with intermediate to high risk and in clinical decision making.

Journal: Proceedings of SPIE--the International Society for Optical Engineering (2022)
Publication types: Journal Article
The political economy of early COVID-19 interventions in US states.

We investigate how politico-economic factors shaped government responses to the spread of covid-19.Our simple framework uses epidemiological, economic and politico-economic arguments.Confronting the theory with us state level data we find strong evidence for partisanship even when we control for fundamentals including the electorate's political views.Moreover, we detect an important role for the proximity of elections which we interpret as indicative of career concerns.Finally, we find suggestive evidence for complementarities between voluntary activity reductions and government imposed restrictions.

Journal: Journal of economic dynamics & control (2022)
Publication types: Journal Article
Blocking protease-activated receptor 4 alleviates liver injury induced by brain death.

Brain death (bd) induces a systemic inflammatory response that influences donor liver quality.Protease-activated receptor 4 (par4) is a thrombin receptor that mediates platelet activation and is involved in inflammatory and apoptotic processes.Therefore, we investigated the role of par4 blockade in liver injury induced by bd and its associated mechanisms.In this study, we constructed a bd rat model and treated rats with tc y-nh2, a selective par4 antagonist, to block par4 signaling at the onset of bd induction.Our results revealed that par4 protein expression increased in the livers of rats with bd.Par4 blockade alleviated liver injury induced by bd, as indicated by lower serum alt/ast levels and an improvement in histomorphology.Blood platelet activation and hepatic platelet accumulation in bd rats were reduced by par4 blockade.Additionally, par4 blockade attenuated the inflammatory response and apoptosis in the livers of bd rats.Moreover, the activation of nf-κb and mapk pathways induced by bd was inhibited by par4 blockade.Thus, our results suggest that par4 contributes to liver injury induced by bd by regulating inflammation and apoptosis through the nf-κb and mapk pathways.Thus, par4 blockade may provide a feasible approach to improve the quality of organs from bd donors.

Journal: Biochemical and biophysical research communications (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Why do you have sex and does it make you feel better? Integrating attachment theory, sexual motives, and sexual well-being in long-term couples.

Attachment theory postulates that three behavioral systems are central to optimal couple functioning: attachment, caregiving, and sex.However, few studies have examined the concurrent contribution of these systems to understand sexual well-being.This daily diary study examined the intermediary role of attachment- and caregiving-related sexual motives in the associations linking attachment insecurities and positive and negative emotions during sexual activity in 149 long-term mixed-gender/sex couples.Multilevel analyses revealed that individuals higher in attachment avoidance endorsed less caregiving sexual motives, which was associated with their own more negative emotional experience during sexual activity.Individuals higher in attachment anxiety endorsed more attachment sexual motives, which was associated with their own and their partner's more negative emotional experience during sex.However, individuals higher in attachment anxiety also concurrently endorsed more caregiving sexual motives, which predicted their own and their partner's more positive emotional experience during sex.Overall, the findings support the associations between the attachment, caregiving, and sexual behavioral systems and suggest that engaging in sex as a way to care for one's partner might foster sexual well-being in long-term couples.

Journal: Journal of social and personal relationships (2022)
Publication types: Journal Article
Genetic Polymorphism of 27 Y-STR Loci in the Western Kazakh Tribes from Kazakhstan and Karakalpakstan, Uzbekistan.

Data on the genetic polymorphism of 27 y-str in kazakhs of the junior zhuz has been presented and analyzed in relation to forensic features.A total of 464 representatives of the western kazakh tribes of kazakhstan (western kazakhs,n= 405) and uzbekistan (karakalpakstan kazakhs,n= 59) were examined by the yfiler plus set.The data are available in the yhrd under accession numbers ya006010 and ya006009.Genetic analysis (amova and mds) did not show significant differences between the two groups (kazakhstan and karakalpakstan kazakhs) in terms of y-chromosome diversity.Both groups are characterized by haplogroup c2a1a2 as a founder effect, which dominated two of the three tribes: alimuly (67%), baiuly (74.6%), and zhetiru (25.8%).At the same time, the phylogenetic network for each tribe found its own clusters within c2a1a2.Western kazakhs and karakalpakstan kazakhs present high values of unique haplotypes (84.44% and 96.61%), discrimination capacity (90.37% and 98.30%), and haplotype diversity (0.9991 and 0.9994).A set of 27 y-str loci distinguishes closely related individuals within the western kazakh tribes quite well.It is suitable for forensic application, and is also optimal for population genetics studies.

Journal: Genes (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Perinatal outcome after planned vaginal delivery in monochorionic compared with dichorionic twin pregnancy.

To assess, according to chorionicity, the perinatal outcome of twin pregnancy in which vaginal delivery is planned.Methods jumoda (jumeaux mode d'accouchement) was a national prospective population-based cohort study of twin pregnancies, delivered in 176 maternity units in france, from february 2014 to march 2015.In this planned secondary analysis, we assessed, according to chorionicity, the perinatal outcome of twin pregnancies, in which vaginal delivery was planned, that delivered at or after 32 weeks of gestation with the first twin in cephalic presentation.In order to select a population with well-recognized indications for planned vaginal delivery, we applied the same exclusion criteria as those in the twin birth study, an international randomized trial.Monochorionic twin pregnancies with twin-to-twin transfusion syndrome or twin anemia-polycythemia sequence were defined as complicated and were excluded.The primary outcome was a composite of intrapartum mortality and neonatal morbidity and mortality.Multivariable logistic regression models were used to control for potential confounders.Subgroup analyses were conducted according to birth order (first or second twin) and gestational age at delivery (< 37 or ≥ 37 weeks of gestation).Results among 3873 twin pregnancies, in which vaginal delivery was planned, that delivered at ≥ 32 weeks' gestation with the first twin in cephalic presentation, meeting the inclusion criteria of the twin birth study, 729 (18.8%) were uncomplicated monochorionic twin pregnancies and 3144 (81.2%) were dichorionic twin pregnancies.The rate of composite intrapartum mortality and neonatal morbidity and mortality did not differ between uncomplicated monochorionic (27/1458 (1.9%)) and dichorionic (107/6288 (1.7%)) twin pregnancies when adjusting for conception by assisted reproductive technologies (adjusted relative risk, 1.07 (95% ci, 0.66-1.75)).No significant difference in the primary outcome was found between the groups on subgroup analyses according to birth order and gestational age at delivery.Conclusion when vaginal delivery is planned, and delivery occurs at ≥ 32 weeks of gestation with the first twin in cephalic presentation, uncomplicated monochorionic twin pregnancy is not associated with a higher rate of composite intrapartum mortality and neonatal morbidity and mortality compared with dichorionic twin pregnancy.© 2020 international society of ultrasound in obstetrics and gynecology.

Journal: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2021)
Publication types: Journal Article;Multicenter Study;Observational Study;Research Support, Non-U.S. Gov't
A Cadaveric Study of the Buccal Fat Pad: Implications for Closure of Palatal Fistulae and Donor-Site Morbidity.

For the cleft surgeon, palatal fistulae after cleft palate repair remain a difficult problem, with a paucity of local tissue options to aid closure.Small clinical series have described the use of the buccal fat pad flap to repair palatal fistulae; however, there is no literature detailing the anatomical coverage of the flap.This study delineates the anatomy of the buccal fat pad flap to guide surgeons in patient selection and examines the residual buccal fat after flap harvest to provide new information with regard to possible effects on the donor site.Methods buccal fat pad flaps were raised in 30 hemicadavers.The reach of the flap across the midline, anteriorly and posteriorly, was recorded.In 18 hemicadavers, the entire buccal fat pad was then exposed to determine the effects of flap harvest on movement and volume of the residual fat.Results all buccal fat pad flaps provided coverage from the soft palate to the posterior third of the hard palate and all across the midline.Approximately three-fourths of flaps would cover the mid hard palate.The flap constitutes 36 percent of the total buccal fat pad on average, and a series of retaining ligaments were identified that may prevent overresection.Conclusions the buccal fat pad flap is a useful tool for coverage of fistulae in the soft palate to the posterior third of the hard palate.In most cases, it will also reach the middle third; however, it is not suitable for more anterior defects.On average, two-thirds of the buccal fat pad remains within the cheek after flap harvest, which may protect against unwanted alteration in aesthetics.

Journal: Plastic and reconstructive surgery (2020)
Publication types: Journal Article
State-of-play for cellular therapies in cardiac repair and regeneration.

Cardiovascular disease is the primary cause of death around the world.For almost two decades, cell therapy has been proposed as a solution for heart disease.In this article, we report on the "state-of-play" of cellular therapies for cardiac repair and regeneration.We outline the progression of new ideas from the preclinical literature to ongoing clinical trials.Recent data supporting the mechanics and mechanisms of myogenic and paracrine therapies are evaluated in the context of long-term cardiac engraftment.This discussion informs on promising new approaches to indicate future avenues for the field.

Journal: Stem cells (Dayton, Ohio) (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Atherogenic potential of microgravity hemodynamics in the carotid bifurcation: a numerical investigation.

Long-duration spaceflight poses multiple hazards to human health, including physiological changes associated with microgravity.The hemodynamic adaptations occurring upon entry into weightlessness have been associated with retrograde stagnant flow conditions and thromboembolic events in the venous vasculature but the impact of microgravity on cerebral arterial hemodynamics and function remains poorly understood.The objective of this study was to quantify the effects of microgravity on hemodynamics and wall shear stress (wss) characteristics in 16 carotid bifurcation geometries reconstructed from ultrasonography images using computational fluid dynamics modeling.Microgravity resulted in a significant 21% increase in flow stasis index, a 22-23% decrease in wss magnitude and a 16-26% increase in relative residence time in all bifurcation branches, while preserving wss unidirectionality.In two anatomies, however, microgravity not only promoted flow stasis but also subjected the convex region of the external carotid arterial wall to a moderate increase in wss bidirectionality, which contrasted with the population average trend.This study suggests that long-term exposure to microgravity has the potential to subject the vasculature to atheroprone hemodynamics and this effect is modulated by subject-specific anatomical features.The exploration of the biological impact of those microgravity-induced wss aberrations is needed to better define the risk posed by long spaceflights on cardiovascular health.

Journal: NPJ microgravity (2022)
Publication types: Journal Article
Role of TRPV4 in the Diagnosis and Treatment ofHelicobacter pyloriInfection in Children with Duodenal Ulcers.

Duodenal ulcer seriously affects the quality of life and life safety of children, but the pathogenesis of children with duodenal ulcer is still unclear.As an important second messenger in the body, ca2+participates in the physiological and pathological processes of various diseases.Therefore, transient receptor potential vanilloid type 4 (trpv4) as one of the channels that mediate ca2+has attracted widespread attention in recent years.Here, we found that trpv4 is highly expressed in children with duodenal ulcer and has good diagnostic value through specimens of children with duodenal ulcer, and animal experiments have proved that trpv4 is also highly expressed in duodenal ulcer mice.In addition, trpv4 can enhance intestinal permeability, thereby promoting further infiltration of inflammatory factors.In summary, these results indicate that trpv4 is involved in the occurrence and development of duodenal ulcer.Therefore, this study provides the diagnostic and therapeutic value of trpv4 in children with duodenal ulcer.

Journal: BioMed research international (2022)
Publication types: Clinical Trial;Journal Article