syedzayyan/paper_mill_benchmark huggingface dataset:
Expert consensus on the diagnosis and treatment of myofascial pain syndrome.

Myofascial pain syndrome (mps) is characterized by myofascial trigger points and fascial constrictions.At present, domestic and foreign scholars have not reached a consensus on the etiology and pathogenesis of mps.Due to the lack of specific laboratory indicators and imaging evidence, there is no unified diagnostic criteria for mps, making it easy to confuse with other diseases.The chinese association for the study of pain organized domestic experts to formulate this chinese pain specialist consensus on the diagnosis and treatment of mps.This article reviews relevant domestic and foreign literature on the definition, epidemiology, pathogenesis, clinical manifestation, diagnostic criteria and treatments of mps.The consensus is intended to normalize the diagnosis and treatment of mps and be used by first-line doctors, including pain physicians to manage patients with mps.

Journal: World journal of clinical cases (2021)
Publication types: Journal Article;Review
Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow.

Breast cancer (bc) stem cells (cscs) resist treatment and can exist as dormant cells in tissues such as the bone marrow (bm).Years before clinical diagnosis, bc cells (bccs) could migrate from the primary site where the bm niche cells facilitate dedifferentiation into cscs.Additionally, dedifferentiation could occur by cell autonomous methods.Here we studied the role of msi 1, a rna-binding protein, musashi i (msi 1).We also analyzed its relationship with the t-cell inhibitory molecule programmed death-ligand 1 (pd-l1) in cscs.Pd-l1 is an immune checkpoint that is a target in immune therapy for cancers.Msi 1 can support bcc growth through stabilization of oncogenic transcripts and modulation of stem cell-related gene expression.We reported on a role for msi 1 to maintain cscs.This seemed to occur by the differentiation of cscs to more matured bccs.This correlated with increased transition from cycling quiescence and reduced expression of stem cell-linked genes.Cscs co-expressed msi 1 and pd-l1.Msi 1 knockdown led to a significant decrease in cscs with undetectable pd-l1.This study has implications for msi 1 as a therapeutic target, in combination with immune checkpoint inhibitor.Such treatment could also prevent dedifferentiation of breast cancer to cscs, and to reverse tumor dormancy.The proposed combined treatment might be appropriate for other solid tumors.

Journal: Aging (2023)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Preoperative Planning Using Three-dimensional Printing for Full-endoscopic Spine Surgery: A Technical Note.

Transforaminal full-endoscopic spine surgery (tf-fess) is a novel minimally invasive spine surgery that requires only an 8-mm skin incision and causes minimal damage to the paravertebral muscles.To perform tf-fess safely and efficiently, preoperative planning is quite important as the intervention requires anatomical understanding and high technical skills.Recently, three-dimensional (3d) printing has become a useful tool in various surgeries, and several studies have addressed its efficacy; however, there are no reports on the application of 3d printing to fess.In this study, we present two cases of severe lumbar deformities for which preoperative 3d printing was useful.The 3d printing enabled the surgeons to visualize and plan the drilling of the superior articular process for a successful foraminoplasty at a low cost.The manufacturing equipment cost about usd 900 and is able to produce an actual-size model at a cost of less than usd 10 per patient.In conclusion, preoperative planning using 3d printing should be adopted to safely perform fess.

Journal: NMC case report journal (2022)
Publication types: Case Reports;Journal Article
Acute severe hepatitis of unknown etiology in children: A mini-review.

The emergence of acute, severe non hep a-e hepatitis of unknown etiology (ashue) has attracted global concern owing to the very young age of the patients and its unknown etiology.Although this condition has been linked to several possible causes, including viral infection, drugs and/or toxin exposure, the exact cause remains unknown; this makes treatment recommendation very difficult.In this review, we summarize recent updates on the clinical manifestations, complemented with laboratory results, case numbers with the global distribution and other epidemiological characteristics, and the possible etiologies.We also provide the proposed actions that could be undertaken to control and prevent further spread of this hepatitis.Since many etiological and pathological aspects of the acute non hep a-e hepatitis remain unclear, further research is needed to minimize the severe impact of this disease.

Journal: Narra J (2022)
Publication types: Journal Article;Review
Biomarker Profiling of Neurovascular Diseases in Patients with Stage 5 Chronic Kidney Disease.

Patients with stage 5 chronic kidney disease (ckd5d) have a higher risk of developing neurocognitive deficits.Stroke, cervical carotid artery disease (ccad), and intracranial atherosclerotic disease (icad) are causes of such deficits in ckd5d.Chronic inflammation from renal failure elevates risk for these diseases through oxidative stress and vascular dysfunction.The adverse impact on the carotid and intracranial vasculatures contributes to the multifactorial pathophysiology of stroke.Eleven plasma biomarker levels in patients with ckd5d (n = 97) and healthy controls (n = 17-50) were measured using sandwich enzyme-linked immunosorbent assay (elisa) method.Of the 97 patients with ckd5d, 24 had ccad, 19 had icad, and 23 had acute stroke.Elevations in nacht, lrr, and pyd domains-containing protein 3 (nalp3) levels in patients with ckd5d (+)ccad (1.80 ± 0.11 ng/m l) compared to patients with (-)ccad (1.55 ± 0.08 ng/m l) were statistically significant (p= .0299).Differences in d-dimer levels were also found to be statistically significant (p= .0258) between ckd5d (+)stroke (1.83 ± 0.42 μg/m l) and (-)stroke (0.89 ± 0.13 μg/m l) groups.The ages of the (+) neurovascular disease groups were found to be significantly elevated compared to the (-) neurovascular disease groups (p= .0002 carotid ad;p< .0001 icad;p= .0157 stroke).D-dimer levels were positively correlated with age in ckd5d (p= .0375).With the possible exception of nalp3 for ccad, profiling levels of specific biomarkers for risk stratification of neurovascular diseases in the ckd5d population warrants further investigation.

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis (2018)
Publication types: Journal Article
Considering difference: clinician insights into providing equal and equitable burns care for Aboriginal and Torres Strait Islander children.

To better understand issues driving quality in burn care related to equity of outcomes and equality of provision for aboriginal and torres strait islander children.Methods seventy-six interviews with team members who provide care for aboriginal and torres strait islander children in six paediatric burn units across five australian jurisdictions were completed.Interface research methodology within a qualitative design guided data collection and analysis.Results three themes were identified: i) burn team members who identify the requirement to meet the specific needs of aboriginal and torres strait islander children and deliver differential care; ii) burn team members who believe in equal care, but deliver differential care based on the specific needs of aboriginal and torres strait islander children; and iii) burn team members who see little need for provision of differential care for aboriginal and torres strait islander children and rather, value the provision of equal care for all.Conclusion burn team members conflate equitable and equal care, which has implications for the delivery of care for aboriginal and torres strait islander children.Equitable care is needed to address disparities in post-burn outcomes, and this requires clinicians, healthcare services and relevant system structures to work coherently and intentionally to reflect these needs.Implications for public health: changes in health policy, the embedding of aboriginal and torres strait islander liaison officers in burn care teams and systems that prioritise critical reflexive practice are fundamental to improving care.

Journal: Australian and New Zealand journal of public health (2021)
Publication types: Journal Article
Distribution Pattern and Influencing Factors of Heavy Metal Resistance Genes in the Yellow River Sediments of Henan Section.

The transformation of heavy metal resistance genes (mrgs) in the environment has attracted increasing attention in recent years.However, few studies have reported the mrg content in the yellow river, one of the main irrigation water sources in the north china plain.In this study, we quantified mrg abundance by a metagenomic approach, and assessed the influence on mrgs of both bioavailable and total heavy metal (hm) content.The results indicate that cu-resistant genes are the most common genes, and the prevalence ofars m needs more attention.comamonadaceaeis the dominant family in the yellow river, and the presence of organic pollutants may contribute to the prevalence of vicinamibacteraceae,nocardioidaceae, and flavobacteriacea.The results of the mantel test and spearman analysis indicate that both the bioavailable fractions and total content of hms could have little influence on mrgs.Network analysis results indicate that some dominant bacteria could be the potential hosts of some prevalent mrgs, which may exert an adverse impact on human health.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Evaluating the Application of Chronic Heart Failure Therapies and Developing Treatments in Individuals With Recent Myocardial Infarction: A Review.

Importance despite advances in cardiac care, patients remain at a high risk of death and the development of heart failure (hf) following myocardial infarction (mi).These risks are highest in patients with reduced ejection fraction (ef) or signs of hf immediately after mi.Drugs to mitigate these risks have been identified through the systematic evaluation of therapies with proven efficacy in patients with hf and reduced ef (hfr ef).Observations although landmark studies in patients with hfr ef consistently exclude patients with recent mi, dedicated post-mi trials of these drugs have led to multiple therapies with proven benefit in these patients.However, not all therapies with proven efficacy in patients with chronic hf have been shown to provide benefit in the post-mi population, as recently evidenced by the discrepant results between chronic hf and post-mi trials of sacubitril-valsartan.Similarly, multiple trials of early and aggressive use of therapies effective in chronic heart failure immediately post-mi failed to demonstrate benefit or were associated with harm, emphasizing the vulnerability of the post-mi population.Conclusions and relevance trials of patients at high risk of hf following mi have emphasized the differences between the post-mi and hfr ef populations and the necessity for dedicated trials in the post-mi population.This review summarizes trials studying the use of these therapies for at-risk patients following mi from therapies used in patients with hfr ef and exploring new potential therapies for this high-risk population.

Journal: JAMA cardiology (2022)
Publication types: Journal Article;Review
Riding brain "waves" to identify human memory genes.

While there is extensive research on memory-related oscillations and brain gene expression, the relationship between oscillations and gene expression has rarely been studied.Recently, progress has been made to identify specific genes associated with oscillations that are correlated with episodic memory.Neocortical regions, in particular the temporal pole, have been examined in this line of research due to their accessibility during neurosurgical procedures.By harnessing this accessibility, a unique and powerful study design has allowed gene expression and intracranial oscillatory data to be sourced from the same human patients.These studies have identified a plethora of understudied gene targets that should be further characterized with respect to human brain function.Future work should extend to other brain regions to increase our understanding of the genetic signatures of oscillations and, ultimately, human cognition.

Journal: Current opinion in cell biology (2022)
Publication types: Journal Article;Review;Research Support, Non-U.S. Gov't;Research Support, N.I.H., Extramural
Microvascular assessment of macula, choroid, and optic disk in children with unilateral amblyopia using OCT angiography.

To investigate the microvascular changes of macula, choroid, and optic disk in children with unilateral amblyopia.Methods this prospective cross-sectional study involved 39 unilateral amblyopic children and 39 age- and sex-matched heathy participants who served as control.Vessel densities of the superficial and deep capillary plexuses (scp and dcp), foveal avascular zone (faz) area, macular thickness, optic disk vessel density, retinal nerve fiber layer (rnfl) thickness, choriocapillaris vessel density, and subfoveal choroidal thickness were evaluated by oct angiography (octa).Meanwhile, the correlations of microvascular perfusion and structural changes of macula, choroid, and optic disk were analyzed.Results the vessel density of scp and dcp in the whole macula in the amblyopic group was significantly lower than that in the control group after adjusting for age, axial length, and spherical equivalents (all p 0.05).Subfoveal choroidal thickness of amblyopic eyes was significantly higher than that of control eyes(p = 0.032).Choriocapillaris flow void (fv) in the amblyopic group was greater than that in the control group (p = 0.013).Significant differences were observed between the fellow eyes and the control eyes in choriocapillaris fv and subfoveal choroidal thickness (p = 0.011 and p = 0.042, respectively).Foveal scp and dcp vessel density in all studied eyes were positively correlated with the whole macular thickness, respectively (r = 0.556 and r = 0.627, respectively, both p < 0.001).Whole scp and dcp vessel density in the amblyopic eyes were negatively correlated with choriocapillaris fv (r = -0.723, p < 0.001; r = -0.512, p = 0.001, respectively).Conclusion children with amblyopic eyes have attenuated macular and choriocapillaris perfusion.There is a need for future studies that will investigate the pathophysiology of amblyopia in children by octa.

Journal: International ophthalmology (2022)
Publication types: Journal Article
Continued alcohol consumption and hepatic encephalopathy determine quality of life and psychosocial burden of caregivers in patients with liver cirrhosis.

Patients with liver cirrhosis suffer from significantly reduced health-related quality of life and are often dependent on support from caregivers.In this context, caregivers often suffer from impaired quality of life (qo l) as well as psychosocial burden (pb).The aim of the present study was to identify factors influencing qo l and pb of caregivers in order to improve the social care of patients and caregivers.Methods in this cross-sectional study, 106 patients with liver cirrhosis and their caregivers were included.(health-related) qo l was surveyed in patients (cldq) and caregivers (sf-36) and pb was determined by zarit burden interview.Results alcohol related liver cirrhosis (55%) was the predominant etiology of liver cirrhosis and the median meld of the cohort was 14.Qo l did not differ between patients with and without alcohol-related liver cirrhosis (p = 0.6).In multivariable analysis, continued alcohol consumption (p = 0.020), a history of hepatic encephalopathy (he) (p = 0.010), poorer qo l of patients (p = 0.030) and poorer qo l of caregivers (p = 0.005) were associated with a higher pb of caregivers.Factors independently associated with poorer qo l of caregivers were continued alcohol consumption (p = 0.003) and a higher pb of caregivers (p = 0.030).Conclusion caregivers of patients with liver cirrhosis suffer from impaired qo l and pb, especially in case of continued alcohol consumption or the occurrence of he.

Journal: Health and quality of life outcomes (2022)
Publication types: Journal Article
How COVID-19 Changed Advance Care Planning: Insights From the West Virginia Center for End-of-Life Care.

Context coronavirus disease 2019 (covid-19) led to increased attention nationally on advance care planning.Objectives to describe the impact covid-19 had on advance care planning based on changes in the calls to the west virginia center for end-of-life care (center) and in the volume and types of documents requested from and submitted to the center and its e-directive registry (registry).Methods a retrospective and observational analysis between january 1, 2020 and june 30, 2020 of calls to the center; advance directives downloaded from the center's web site as well as mailed to the public and medical orders mailed to health care professionals on request to the center; and advance directives and medical orders submitted to the registry.Results the nature of calls changed to covid-19-related topics, including confirmation of forms on the registry, urgent desire to initiate advance care planning, temporary rescindment of treatment-limiting forms, and questions on how to honor patients' wishes in advance directives and medical orders in light of their covid-19 status.Also in the first six months of 2020, the center distributed more advance directives than it had during the same months in the last five years and more medical orders than it had in the preceding four years when there were no revisions to the medical order forms required by changes to the state law.Conclusion covid-19 resulted in a new sense of urgency regarding advance care planning by west virginians with increased attention to document their wishes and ensure that they were in the registry.

Journal: Journal of pain and symptom management (2020)
Publication types: Journal Article;Observational Study
Ultrafast multi-photon excitation of ScVO4:Bi3+for luminescence thermometry.

We demonstrate a multi-photon excitation (mpe) scheme for luminescence thermometry using sc vo4:bi3+.Mpe is performed using a 37 fs ti:sapphire laser pulse centered at 800 nm.Log-log plots of the phosphorescence intensity versus excitation power show that the 800 nm mpe of sc vo4:bi3+involves a 2- and 3-photon absorption process in comparison with a single-photon excitation (spe) process at 266 and 400 nm.Spectroscopic investigation shows that with the 800 nm mpe and 266 nm spe schemes, the emission spectra of sc vo4:bi3+are similarly characterized by emissions of the vo43-groups and bi3+.Mpe is advantageous to suppress fluorescence that interferes with the phosphorescence signal.We demonstrate this aspect for a sc vo4:bi3+coating applied on an alumina substrate.The luminescence lifetime is calibrated with temperature in the range of 294-334 k; the mpe scheme has an equally impressive temperature sensitivity (3.4-1.7%/k) and precision (0.2-0.7 k) compared with the spe schemes.The mpe scheme can be applied to a variety of phosphors and is valuable for precise temperature measurements, even in applications where isolating interfering background emissions is challenging.

Journal: Optics letters (2022)
Publication types: Journal Article
Planning and Optimization of Software-Defined and Virtualized IoT Gateway Deployment for Smart Campuses.

The internet of things (io t) is based on objects or "things" that have the ability to communicate and transfer data.Due to the large number of connected objects and devices, there has been a rapid growth in the amount of data that are transferred over the internet.To support this increase, the heterogeneity of devices and their geographical distributions, there is a need for io t gateways that can cope with this demand.The softway4io t project, which was funded by the national education and research network (rnp), has developed a software-defined and virtualized io t gateway that supports multiple wireless communication technologies and fog/cloud environment integration.In this work, we propose a planning method that uses optimization models for the deployment of io t gateways in smart campuses.The presented models aimed to quantify the minimum number of io t gateways that is necessary to cover the desired area and their positions and to distribute io t devices to the respective gateways.For this purpose, the communication technology range and the data link consumption were defined as the parameters for the optimization models.Three models are presented, which use lo ra, wi-fi, and ble communication technologies.The gateway deployment problem was solved in two steps: first, the gateways were quantified using a linear programming model; second, the gateway positions and the distribution of io t devices were calculated using the classical k-means clustering algorithm and the metaheuristic particle swarm optimization.Case studies and experiments were conducted at the samambaia campus of the federal university of goiás as an example.Finally, an analysis of the three models was performed, using metrics such as the silhouette coefficient.Non-parametric hypothesis tests were also applied to the performed experiments to verify that the proposed models did not produce results using the same population.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article
Genetic characterization of varicella-zoster and HIV-1 viruses from the cerebrospinal fluid of a co-infected encephalitic patient, Ghana.

Encephalitis is a serious disease of the brain characterized by prodromal and specific neurological symptoms.Hiv infections offer opportunistic viruses, such as varicella-zoster virus (vzv), the chance to cause encephalitis in patients.There is a lack of information on the genetic diversity of vzv in ghana and other parts of africa which requires sequencing and characterization studies to address.The active evolution of hiv-1 in west africa also requires continuous surveillance for the emergence of new genetic forms.Case presentation vzv was detected in the csf sample of an 11-year-old patient presenting with symptoms of encephalitis by real-time pcr diagnostics.To identify possible unknown aetiological pathogens, next-generation sequencing was performed, and revealed an hiv-1 co-infection.Alignments of concatenated hiv-1 genome fragments in the gag, pol, vif, env and nef regions and a near-complete vzv genome were analyzed by bayesian inference, and phylogenetic trees were generated.The vzv sequence belongs to clade 5 and the hiv-1 sequence is a member of the crf02_ag predominant circulating recombinant form in ghana.Conclusions diagnostic tests for csf hiv would be useful where possible in patients presenting with encephalitis due to vzv and other opportunistic viruses in kumasi to shed light on the role of hiv in encephalitis cases in ghana.This report reaffirms the role of the crf02_ag circulating recombinant form in hiv infections in ghana and also gives a preliminary genetic characterization of vzv in kumasi, ghana.

Journal: Virology journal (2022)
Publication types: Case Reports;Journal Article;Research Support, Non-U.S. Gov't