syedzayyan/paper_mill_benchmark huggingface dataset:
Evaluating the Relationship Between Post Traumatic Stress Disorder Symptoms and Psychological Resilience in a Sample of Turkoman Refugees in Turkey.

Turkey has witnessed an increase in migration of people belonging to neighboring countries due to civil war.Traumatic life events experienced by refugees bring along mental problems.Their psychological resilience enables them to cope with these difficulties.In this study, 101 iraqi turkoman refugees who migrated to turkey following the increasing civil war events in their country were evaluated psychologically.Sociodemographic data form resilience scale for adults (rsa) and clinician-administered post-traumatic stress disorder scale (caps) were used for psychological evaluation.The prevalence of lifetime post-traumatic stress disorder (ptsd) among the refugees was 25.7%.There was no significant difference between the psychological resilience of the patients who developed ptsd and those who did not (p = 0.709).As the severity of trauma decreased, psychological resilience increased in the people who developed ptsd (p = 0.001, r = -0.622).Considering the psychological resilience of refugees, the area with the highest resilience is access to social resources, while the area with the lowest is the planned future.It was observed that the basic needs of refugees after migration could not be met clearly compared to the ones before migration.It was noteworthy that in cases diagnosed with ptsd, caps scores increased (p = 0.011, r: 0.251) and resilience decreased (p < 0.001, r: -0.376) as the inability to reach basic needs increased.Our study is very important in terms of defining how refugees are mentally affected after settling in another country and what determines their psychological resilience.

Journal: Journal of immigrant and minority health (2021)
Publication types: Journal Article
Post-harvest contamination of maize by Fusarium verticillioides and fumonisins linked to traditional harvest and post-harvest practices: A case study of small-holder farms in Vietnam.

Together with conducive climatic factors, poor pre-harvest practices of ethnic small-holder farmers are a major cause of the contamination of maize by fusarium verticillioides and fumonisins.The proliferation of this field pathogen and the accumulation of its mycotoxins in post-harvest maize caused by ethnic post-harvest practices of subsistence farms have received little attention.Therefore, this study aimed to evaluate the impact of traditional harvest and post-harvest practices on the proliferation of f.Verticillioides and fumonisins contamination in post-harvest maize of two ethnic groups: ede and kinh from the central highlands of vietnam.In parallel with analysis, a survey on harvest and post-harvest practices of these farmers was conducted from late december 2017 to early january 2019.As a result, four effective post-harvest practices at mitigating the contamination were defined: (1) removal of damaged cobs at harvest, (2) transport of maize home after harvest, (3) shelling maize away from fields, and (4) drying maize on cement yards.These practices were better implemented by kinh households than ede households reducing the post-harvest contamination of maize with f.Verticillioides and fumonisin b1(fb1), fb2, and fb3.Nevertheless, there is still room for improvement with respect to inadequate open-air drying method, poor storage infrastructure, and poor moisture content management as these correlated to the proliferation of f.Verticillioides.Finally, the presence of fumonisins together with aflatoxins in some samples at the storage phase might cause a severe impact on human health.

Journal: International journal of food microbiology (2021)
Publication types: Journal Article
Sepiolite-zeolite powder doped with capric acid phase change microcapsules for temperature-humidity control.

A composite material with temperature-humidity control functions was prepared by using sepiolite-zeolite powder as humidity control matrix and capric acid phase change microcapsules as temperature control material.The micromorphology, thermal conductivity, compressive strength, hygrothermal effect were studied by environmental scanning electron microscope (esem), thermal conductivity test, strength test and hygrothermal effect test, respectively.The results showed that the phase change temperature of capric acid phase change microcapsule is between 31 °c ~ 32 °c, the phase change enthalpy is 123.91 j/g, and it has good thermal stability.The humidity control performance is the best and the maximum humidity absorption rate is 6.28% when sepiolite-zeolite powder ratio is 9:1.The humidity control matrix@cam (capric acid microcapsules) can control the relative humidity of the environment at 51.74 ~ 58.54% and reduce the temperature fluctuation range by 2 °c ~ 3 °c.Capric acid phase change microcapsules are embedded in the interlaced sepiolite and zeolite powder to form a frame space body which produce capillary condensation adsorption and surface adsorption, absorb and desorb heat through phase changes, thus giving humidity control matrix@cam a good temperature-humidity control performance.

Journal: Journal of colloid and interface science (2021)
Publication types: Journal Article
Melatonin Inhibits EMT in Bladder Cancer by Targeting Autophagy.

Melatonin, a naturally biosynthesized molecule secreted by the pineal gland, exhibits antitumor activities against several different types of cancer.The mechanisms of action of melatonin against tumor progression involve cellular apoptosis, antimetastatic activity, antioxidant and mutagenic effects, antiangiogenic activity, and the restoration of cancer immune surveillance.Melatonin has anticancer activity when administered alone or in combination with standard chemotherapeutic agents, with measurable improvements seen in the clinical endpoints of tumor regression and patient survival.However, scant clinical evidence supports the use of melatonin in bladder cancer treatment.Our study has found that melatonin treatment suppresses the bladder cancer cell migratory ability by inhibiting the epithelial-mesenchymal transition (emt) process, which appears to be linked to melatonin-induced decreases in bladder cancer cell autophagy.Finally, an evaluation of in vivo melatonin-induced antitumor effects in an orthotopic animal model of bladder cancer indicated that melatonin treatment slightly prolonged the survival of tumor-bearing mice.Our study offers novel insights into the use of melatonin in bladder cancer treatment.

Journal: Molecules (Basel, Switzerland) (2022)
Publication types: Journal Article
Deletion of gmfA induces keratocyte-like migration in Dictyostelium.

Glia maturation factor (gmf) has been established as an inactivating factor of the actin-related protein 2/3 (arp2/3) complex, which regulates actin assembly.Regulation of actin assembly and reorganization is crucial for various cellular events, such as cell migration, cell division, and development.Here, to examine the roles of adf-h domain-containing protein (also known as glia maturation factor; gmf a), the product of a single gmf homologous gene in dictyostelium, gmf a-null cells were generated.They had moderate defects in cell growth and cytokinesis.Interestingly, they showed a keratocyte-like fan shape with a broader pseudopod, where arp3 accumulated at higher levels than in wild-type cells.They migrated with higher persistence, but their velocities were comparable to those of wild-type cells.The polar pseudopods during cell division were also broader than those in wild-type cells.However, gmf a did not localize at the pseudopods in migrating cells or the polar pseudopods in dividing cells.Adhesions of mutant cells to the substratum were much stronger than that of wild-type cells.Although the mutant cells showed chemotaxis comparable to that of wild-type cells, they formed disconnected streams during the aggregation stage; however, they finally formed normal fruiting bodies.These results suggest that gmf a plays a crucial role in cell migration.

Journal: FEBS open bio (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Genome profiles of pathologist-defined cell clusters by multiregional LCM and G&T-seq in one triple-negative breast cancer patient.

Pathological examination is the gold standard for cancer diagnosis, and breast tumor cells are often found in clusters.We report a case study on one triple-negative breast cancer (tnbc) patient, analyzing tumor development, metastasis, and prognosis with simultaneous dna and rna sequencing of pathologist-defined cell clusters from multiregional frozen sections.The cell clusters are isolated by laser capture microdissection (lcm) from primary tumor tissue, lymphatic vessels, and axillary lymph nodes.Data are reported for a total of 97 cell clusters.A combination of tumor cell-cluster clonality and phylogeny reveals 3 evolutionarily distinct pathways for this patient, each associated with a unique m rna signature, and each correlated with disparate survival outcomes.Hub gene analysis indicates that extensive downregulation of ribosomal protein m rna is a potential marker of poor prognosis in breast cancer.

Journal: Cell reports. Medicine (2021)
Publication types: Case Reports;Journal Article;Research Support, Non-U.S. Gov't
Primary Roux-en-Y Gastric Bypass Results in Greater Weight Loss at 15-Year Follow-Up Compared with Secondary Roux-en-Y Gastric Bypass After Failure of Gastric Band or Mason McLean Vertical Gastroplasty.

The aim of the study is to compare the outcomes of patients treated with secondary roux-en-y gastric bypass (rygb) after adjustable gastric banding (agb) or vertical banded gastroplasty (vbg) with those of patients having primary rygb.Materials and methods patients undergoing secondary rygb after agb or vbg between 1997 and 2004 with a minimal follow-up of 15 years were matched using a propensity score (according to gender, age, bmi, duration of follow-up) with comparable patients who underwent primary rygb.Results the mean follow-up was 16.50 years in the secondary rygb group (n = 32) versus 16.33 years in the primary rygb group (n = 32).Early postoperative complications rate was 6.25% in the secondary rygbs versus 9.38% in the primary rygbs (p = 1).Late postoperative complications and additional surgical procedures were 56.25% and 37.5% in the secondary and primary rygb group, respectively (p = 0.21).Long-term (at 16-20 years) %twl and %ewl were significantly lower (p 0.05).Gastroesophageal reflux was more frequent after secondary rgyb-43.75% versus 25%, p < 0.05.Quality of life-morehead-ardelt ii score (0.02 in secondary rygb versus 0.69 in primary rygb, p = 0.13), general self-assessment of health status and weight satisfaction were comparable.Conclusion secondary rygb after agb or vbg is less efficient at weight loss, gerd remission and energy expenditure at 15 years after conversion.However, it is as effective for improvement/resolution of obesity-related comorbidities and is associated with similar qo l scores.

Journal: Obesity surgery (2020)
Publication types: Journal Article
Advances in Understanding the Genetic Mechanisms of Zebrafish Renal Multiciliated Cell Development.

Cilia are microtubule-based organelles that project from the cell surface.In humans and other vertebrates, possession of a single cilium structure enables an assortment of cellular processes ranging from mechanosensation to fluid propulsion and locomotion.Interestingly, cells can possess a single cilium or many more, where so-called multiciliated cells (mccs) possess apical membrane complexes with several dozen or even hundreds of motile cilia that beat in a coordinated fashion.Development of mccs is, therefore, integral to control fluid flow and/or cellular movement in various physiological processes.As such, mcc dysfunction is associated with numerous pathological states.Understanding mcc ontogeny can be used to address congenital birth defects as well as acquired disease conditions.Today, researchers used both in vitro and in vivo experimental models to address our knowledge gaps about mcc specification and differentiation.In this review, we summarize recent discoveries from our lab and others that have illuminated new insights regarding the genetic pathways that direct mcc ontogeny in the embryonic kidney using the power of the zebrafish animal model.

Journal: Journal of developmental biology (2022)
Publication types: Journal Article;Review
White matter volume loss drives cortical reshaping after thalamic infarcts.

The integration of somatosensory, ocular motor and vestibular signals is necessary for self-location in space and goal-directed action.We aimed to detect remote changes in the cerebral cortex after thalamic infarcts to reveal the thalamo-cortical connections necessary for multisensory processing and ocular motor control.Methods thirteen patients with unilateral ischemic thalamic infarcts presenting with vestibular, somatosensory, and ocular motor symptoms were examined longitudinally in the acute phase and after six months.Voxel- and surface-based morphometry were used to detect changes in vestibular and multisensory cortical areas and known hubs of central ocular motor processing.The results were compared with functional connectivity data in 50 healthy volunteers.Results patients with paramedian infarcts showed impaired saccades and vestibular perception, i.e., tilts of the subjective visual vertical (svv).The most common complaint in these patients was double vision or vertigo / dizziness.Posterolateral thalamic infarcts led to tilts of the svv and somatosensory deficits without vertigo.Tilts of the svv were higher in paramedian compared to posterolateral infarcts (median 11.2° vs 3.8°).Vestibular and ocular motor symptoms recovered within six months.Somatosensory deficits persisted.Structural longitudinal imaging showed significant volume reduction in subcortical structures connected to the infarcted thalamic nuclei (vestibular nuclei region, dentate nucleus region, trigeminal root entry zone, medial lemniscus, superior colliculi).Volume loss was evident in connections to the frontal, parietal and cingulate lobes.Changes were larger in the ipsilesional hemisphere but were also detected in homotopical regions contralesionally.The white matter volume reduction led to deformation of the cortical projection zones of the infarcted nuclei.Conclusions white matter volume loss after thalamic infarcts reflects sensory input from the brainstem as well the cortical projections of the main affected nuclei for sensory and ocular motor processing.Changes in the cortical geometry seem not to reflect gray matter atrophy but rather reshaping of the cortical surface due to the underlying white matter atrophy.

Journal: NeuroImage. Clinical (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The Veterans Affairs's Corporate Data Warehouse: Uses and Implications for Nursing Research and Practice.

The department of veterans affairs veterans healthcare administration (vha) is supported by one of the largest integrated health care information systems in the united states.The vha's corporate data warehouse (cdw) was developed in 2006 to accommodate the massive amounts of data being generated from more than 20 years of use and to streamline the process of knowledge discovery to application.This article describes the developments in research associated with the vha's transition into the world of big data analytics through cdw utilization.The majority of studies utilizing the cdw also use at least one other data source.The most commonly occurring topics are pharmacy/medications, systems issues, and weight management/obesity.Despite the potential benefit of data mining techniques to improve patient care and services, the cdw and alternative analytical approaches are underutilized by researchers and clinicians.

Journal: Nursing administration quarterly (2015)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, P.H.S.
Facile synthesis of isoquinolines and isoquinolineN-oxidesviaa copper-catalyzed intramolecular cyclization in water.

A highly efficient method for the facile access of isoquinolines and isoquinoline n-oxidesviaa cu(i)-catalyzed intramolecular cyclization of (e)-2-alkynylaryl oxime derivatives in water has been developed.This protocol was performed under simple and mild conditions without organic solvent, additives or ligands.By switching on/off a hydroxyl protecting group of oximes, the selective n-o/o-h cleavage could be triggered, delivering a series of isoquinolines and isoquinoline n-oxides, respectively, in moderate to high yields with good functional group tolerance and high atom economy.Moreover, the practicality of this method was further demonstrated by the total synthesis of moxaverine in five steps.

Journal: RSC advances (2022)
Publication types: Journal Article
Notes on three conjectures involving the digamma and generalized digamma functions.

In the paper, we solve one conjecture on an inequality involving digamma function, an open problem, and a conjecture on monotonicity of functions involving generalized digamma function.We also prove a new inequality for digamma function.

Journal: Journal of inequalities and applications (2018)
Publication types: Journal Article
Nanoscale Thermal Cloaking in Silicon Film: A Molecular Dynamic Study.

Nanoscale thermal shielding is becoming increasingly important with the miniaturization of microelectronic devices.They have important uses in the field of thermal design to isolate electronic components.Several nanoscale thermal cloaks based on graphene and crystalline silicon films have been designed and experimentally verified.No study has been found that simultaneously treats the functional region of thermal cloak by amorphization and perforation methods.Therefore, in this paper, we construct a thermal cloak by the above methods, and the ratio of thermal cloaking and response temperature is used to explore its cloaking performance under constant and dynamic temperature boundary.We find that compared with the dynamic boundary, the cloaking effect produced under the constant boundary is more obvious.Under two temperature boundaries, the thermal cloak composed of amorphous and perforated has a better performance and has the least disturbance to the background temperature field.The phonon localization effect produced by the amorphous structure is more obvious than that of the perforated structure.The phonon localization of the functional region is the main reason for the cloaking phenomenon, and the stronger the phonon localization, the lower the thermal conductivity and the more obvious the cloaking effect.Our study extends the nanoscale thermal cloak construction method and facilitates the development of other nanoscale thermal functional devices.

Journal: Materials (Basel, Switzerland) (2022)
Publication types: Journal Article
Atropine Is a Suppressor of Epithelial-Mesenchymal Transition (EMT) That Reduces Stemness in Drug-Resistant Breast Cancer Cells.

Atropine (atr) is extracted from a belladonna plant that belongs to a class of anticholinergic drugs and is therefore involved in the treatment of the overdose of cholinergic drugs or mushroom poisoning.It is a well-known blocker of muscarinic acetylcholine receptors (m ach rs) that are expressed in various tumor cells, including breast tumors from animal and human origin, but it has yet to be recommended as an anticancer drug.Our in silico docking analysis indicates that atropine has a roust virtual binding, with a stable binding energy, to two major signaling molecules involved in emt regulation: e-cad and zeb-2.For both, the gene and the protein expression level results show that atropine is an effective molecule in reducing epithelial-mesenchymal transition (emt) and colony formation induced by tgf-b or carboplatin in both the mesenchymal-like cell line mda-mb-231 and the epithelial-like cell line t47d.We conclude that atropine as a potential suppressor of emt could be co-administrated with other chemotherapeutic drugs to reduce stemness in drug-resistant breast tumor cells.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article
The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice.

Depression is a highly prevalent and debilitating condition, only partially addressed by current pharmacotherapies.The lack of response to treatment by many patients prompts the need to develop new therapeutic alternatives and to better understand the etiology of the disorder.Pre-clinical models with translational merits are rudimentary for this task.Here we present a protocol for the unpredictable chronic mild stress (ucms) method in mice.In this protocol, adolescent mice are chronically exposed to interchanging unpredictable mild stressors.Resembling the pathogenesis of depression in humans, stress exposure during the sensitive period of mice adolescence instigates a depressive-like phenotype evident in adulthood.Ucms can be used for screenings of antidepressants on the variety of depressive-like behaviors and neuromolecular indices.Among the more prominent tests to assess depressive-like behavior in rodents is the sucrose preference test (spt), which reflects anhedonia (core symptom of depression).The spt will also be presented in this protocol.The ability of ucms to induce anhedonia, instigate long-term behavioral deficits and enable reversal of these deficits via chronic (but not acute) treatment with antidepressants strengthens the protocol's validity compared to other animal protocols for inducing depressive-like behaviors.

Journal: Journal of visualized experiments : JoVE (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Video-Audio Media
The role of thermal diffusion, particle clusters, hydrodynamic and magnetic forces on the flow behaviour of magneto-polymer composites.

In this paper, we study the shear-induced flow of magneto-polymer composites, consisting of dispersions of magnetic particles in solutions of polymers, as a competition between the colloidal forces amid particles and their bulk transport induced by the hydrodynamic forces.For this aim, we analyse the role of different experimental parameters.Firstly, by using only solutions of a well-known anionic polymer (sodium alginate), we provoke a moderate hindering of particle movement, but keeping the liquid-like state of the samples.On the contrary, a gel-like behaviour is conferred to the samples when a cationic polymer (chitosan) is additionally added, which further reduces the particle movement.We analyse the effect of an applied magnetic field, which is opposed to particle transport by hydrodynamic forces, by inducing magnetic attraction between the particles.We perform the analysis under both stationary and oscillatory shear.We show that by using dimensionless numbers the differences between samples and experimental conditions are emphasized.In all cases, as expected, the transport of particles driven by bulk hydrodynamic forces dominates at high values of the shear rate.This article is part of the theme issue 'transport phenomena in complex systems (part 1)'.

Journal: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences (2021)
Publication types: Journal Article