syedzayyan/paper_mill_benchmark huggingface dataset:
Purely Organic Microparticles Showing Ultralong Room Temperature Phosphorescence.

Currently, organic phosphorescent particles are heavily used in sensing and imaging.Up to now, most of these particles contain poisonous and/or expensive metal complexes.Environmentally friendly systems are therefore highly desired.A purely amorphous system consisting of poly(methyl methacrylate) particles with incorporated n,n,n',n'-tetrakis(4-carboxyphenyl)benzidine emitter molecules is presented in this work.Single particles with sizes between 400 and 840 nm show-depending on the environment-bright fluorescence and phosphorescence.The latter is observed when oxygen is not in the proximity of the emitting dye molecules.These particles can scavenge singlet oxygen, which is produced during the photoexcitation process, by incorporating it into the polymer matrix.This renders their use to be unharmful for the surrounding matter with possible application in marking schemes for living bodies.

Journal: ACS omega (2021)
Publication types: Journal Article
Tailor-Made Engineering of Bioinspired Inks for Writing Barcode-like Multifunctional Sensory Electronics.

This letter reports on a novel cost-efficient and multifunctional barcode-like sensors array (blsa) printed with a conductive bioinspired smart ink.The conductive ink (p@g ink), which can be further chemically engineered with different organic ligands, was generated via facile one-pot hydrothermal reduction of graphene oxide (go) in dopamine (da) as coreductan usingvarious chemical derivatives of the p@g inks on a flexible substrate (e.g., kapton), a highly integrated blsa as well as smart nose/tongue mimic array were generated for simultaneous sensing and distinguishing of complex physical and chemical stimuli, including temperature, light, air pressure, relative humidity, and volatile organic compounds (vocs).Due to these very attractive features, the reported p@g ink-based blsa would have the potential for unique opportunities regarding "all-in-one"-yet cost-effective-disposable electronics and sensors.

Journal: ACS sensors (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Low voltage areas in paroxysmal atrial fibrillation: The prevalence, risk factors and impact on the effectiveness of catheter ablation.

The prevalence, risk factors of left atrial low voltage areas (lva) in paroxysmal atrial fibrillation (paf) and the impact of lva on the effectiveness of circumferential pulmonary vein isolation (cpvi) were not fully clarified.Methods one hundred fifty patients (mean age 64.7 years, 89 males) with paf were consecutively enrolled to undergo cpvi.Prior to ablation a contact force sensing ablation catheter was utilized for lva mapping in sinus rhythm.The patients were graded based on the proportion of lva (lva%): non lva, mild (lva% ≤ 10%), moderate (lva% 10%- 60% of patients with paf.Female gender and lasa were two risk factors of lva.Lva grade was an independent predictor for af recurrence following cpvi.

Journal: International journal of cardiology (2018)
Publication types: Journal Article
Urinary Biomarkers in Bladder Cancer: Where Do We Stand and Potential Role of Extracellular Vesicles.

Extracellular vesicles (evs) are small membrane vesicles released by all cells and involved in intercellular communication.Importantly, evs cargo includes nucleic acids, lipids, and proteins constantly transferred between different cell types, contributing to autocrine and paracrine signaling.In recent years, they have been shown to play vital roles, not only in normal biological functions, but also in pathological conditions, such as cancer.In the multistep process of cancer progression, evs act at different levels, from stimulation of neoplastic transformation, proliferation, promotion of angiogenesis, migration, invasion, and formation of metastatic niches in distant organs, to immune escape and therapy resistance.Moreover, as products of their parental cells, reflecting their genetic signatures and phenotypes, evs hold great promise as diagnostic and prognostic biomarkers.Importantly, their potential to overcome the current limitations or the present diagnostic procedures has created interest in bladder cancer (bca).Indeed, cystoscopy is an invasive and costly technique, whereas cytology has poor sensitivity for early staged and low-grade disease.Several urine-based biomarkers for bca were found to overcome these limitations.Here, we review their potential advantages and downfalls.In addition, recent literature on the potential of evs to improve bca management was reviewed and discussed.

Journal: Cancers (2020)
Publication types: Journal Article;Review
Does Drug Holiday Affect Jaw Trabeculation in Medication Related Osteonecrosis of the Jaw? - A Pilot Study.

The role of drug holiday in long term antiresorptive drug users to prevent mronj is debated for quite some time.We aimed to compare jawbone trabeculation between patients on drug holiday with those not on drug holiday among medication related osteonecrosis of the jaw (mronj) cases using fractal analysis and to estimate the frequency of mronj despite being on drug holiday.Material and methods the sample of 18 mronj cases were divided into drug holiday, and non-drug holiday groups.Non-drug holiday group was further divided into pre- and post- drug holiday groups.Jawbone trabeculation was assessed utilizing fractal analysis method (image j software) by two observers.Anova was used to compare the fractal dimension (fd) values between the groups.A 'p' value of less than 0.05 was considered significant.Results 8 patients developed mronj despite being on drug holiday (44.44%).There was no significant difference in the fd values between drug holiday and pre-drug holiday groups.When pre- and post-drug holiday fd values were compared, the difference was significant only on the right maxilla with observer 2.Also, no significant difference was noted between the two observers.Conclusions bone trabeculation remained unaltered following drug holiday from anti-resorptive drugs.This study serves as a preliminary proof for the argument against drug holiday which portrays the necessity for a detailed prospective study in this arena.key words:osteonecrosis, bisphosphonates, bisphosphonate-associated osteonecrosis of the jaw, anti-resorptive drugs, osteoporosis, jaw.

Journal: Journal of clinical and experimental dentistry (2022)
Publication types: Journal Article
"They Just Assume That We're All Going to Do the Wrong Thing With It. It's Just Not True": Stakeholder Perspectives About Peripherally Inserted Central Catheters in People Who Inject Drugs.

In the absence of adequate harm reduction opportunities, people who inject drugs (pwid) are at increased risk for serious infections.Infectious diseases guidelines recommend extended periods of intravenous antibiotic treatment through peripherally inserted central catheters (piccs), but pwid are often deemed unsuitable for this treatment.We conducted semi-structured interviews and focus groups to understand the perspectives and opinions of patients and clinicians on the use of piccs for pwid.Methods we approached patients and clinicians (doctors, nurses, picc nurses, social workers, and case workers) involved in patient care at tufts medical center (boston, massachusetts) between august 2019 and april 2020 for semi-structured interviews and focus groups.Results eleven of 14 (79%) patients agreed to participate in an in-depth interview, and 5 role-specific clinician focus groups (1 group consisting of infectious diseases, internal medicine, and addiction psychiatry doctors, 2 separate groups of floor nurses, 1 group of picc nurses, and 1 group of social workers) were completed.Emergent themes included the overall agreement that piccs improve healthcare, patients' feelings that their stage of recovery from addiction was not taken into consideration, and clinicians' anecdotal negative experiences driving decisions on piccs.Conclusions when analyzed together, the experiences of pwid and clinicians shed light on ways the healthcare system can improve the quality of care for pwid hospitalized for infections.Further research is needed to develop a system of person-centered care for pwid that meets the specific needs of patients and improves the relationship between them and the healthcare system.

Journal: Open forum infectious diseases (2022)
Publication types: Journal Article
Using virtual reality in lumbar puncture training improves students learning experience.

Lumbar puncture (lp) is a commonly performed medical procedure in a wide range of indications.Virtual reality (vr) provides a stimulating, safe and efficient learning environment.We report the design and the evaluation of a three dimensions (3d) video for lp training.Methods we recorded a stereoscopic 180-degrees 3d video from two lps performed in clinical settings in fernand widal lariboisière university hospital, paris, france.The video was administered to third-year medical students as well as to a residents and attendings group during lp simulation-based training sessions.Results on 168 participants (108 novice third-year medical students, and 60 residents and attendings with prior lp experience), satisfaction after video exposure was high (rated 4.7 ± 0.6 on a 5-point scale).No significant discomfort was reported (comfort score graded 4.5 ± 0.8 on 5).Lp-naive students displayed higher satisfaction and perceived benefit than users with prior lp experience (overall, p < 0.05).Trainees evaluated favorably the 3d feature and supported the development of similar tutorials for other medical procedures (respectively, 3.9 ± 1.1 and 4.4 ± 0.9 on 5).Conclusion we report our experience with a 3d video for lp training.Vr support could increase knowledge retention and skill acquisition in association to lp simulation training.

Journal: BMC medical education (2022)
Publication types: Journal Article
Tumor necrosis factor α Inhibition for Alzheimer's Disease.

Tumor necrosis factor α (tnf-α) plays a central role in the pathophysiology of alzheimer's disease (ad).Food and drug administration-approved biologic tnf-α inhibitors are thus a potential treatment for ad, but they do not cross the blood-brain barrier.In this short review, we discuss the involvement of tnf-α in ad, challenges associated with the development of existing biologic tnf-α inhibitors for ad, and potential therapeutic strategies for targeting tnf-α for ad therapy.

Journal: Journal of central nervous system disease (2017)
Publication types: Journal Article;Review
Towards an Ensemble Vaccine against the Pegivirus Using Computational Modelling Approaches and Its Validation through In Silico Cloning and Immune Simulation.

Pegivirus, hpg v, which was earlier known as gb virus and hepatitis g virus, is an enveloped, positive-stranded rna and lymphotropic virus classified into the flaviviridaefamily.The transmission routes primarily involve blood products, and infections are worldwide, leading up to 25% of persistent infections.To date, no effective therapeutic means are available to clear pegivirus infections.Effective vaccine therapeutics is the best alternative to manage this disease and any associated potential pandemic.Thus, whole proteome-based mining of immunogenic peptides, i.e., ctl (cytotoxic t lymphocytes), htl (helper t lymphocytes), and b cell epitopes, was mapped to design a vaccine ensemble.Our investigation revealed that 29 different epitopes impart a critical role in immune response induction, which was also validated by exploring its physiochemical properties and experimental feasibility.In silico expression and host immune simulation were examined using an agent-based modeling approach and confirmed the induction of both primary and secondary immune factors such as il, cytokines, and antibodies.The current study warrants further lab experiments to demonstrate its efficacy and safety.

Journal: Vaccines (2021)
Publication types: Journal Article
Prognostic factors in patients with complete response of the tumour (ypT0) after neoadjuvant chemoradiotherapy and radical resection of rectal cancer.

There are only a few studies on the prognosis of patients with complete response of the tumour (yp t0) after neoadjuvant chemoradiotherapy (ncrt) and radical resection of rectal cancer.The aim of the study was to identify prognostic factors with regard to oncological outcome in yp t0 patients after ncrt and radical resection.Methods all yp t0 patients with rectal cancer after ncrt and radical resection between january 2010 and june 2019 were included.Cox univariate and multivariate regression analyses were used to determine the prognostic factors of these patients.Results seventy-six patients with yp t0 rectal cancer were included.In nine patients (11.8%), lymph node metastasis was identified.Age, gender, elevated carcinoembryonic antigen (cea) and yp n+ were risk factors associated with a worse 5-year disease-free survival (dfs) rate in univariate analysis (p = 0.08, 0.14, 0.007 and 0.003, respectively).In multivariate analysis, yp n+ and elevated cea before ncrt were independent risk factors for worse 5-year dfs (p = 0.005 and 0.021, respectively).Elevated cea before ncrt, post-operative chemotherapy and yp n+ were risk factors associated with worse overall survival in univariate analysis (p = 0.14, 0.002 and 0.17, respectively).However, in multivariate analysis, none of these three factors were independent risk factors for worse overall survival (p = 0.20, 0.34 and 0.06, respectively).Conclusion yp n+ and elevated cea before ncrt were found to be independent risk factors for an unfavourable dfs in yp t0 patients with complete response of the tumour after neoadjuvant chemoradiotherapy for rectal cancer.

Journal: ANZ journal of surgery (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
If you can't measure it- you can't change it - a longitudinal study on improving quality of care in hospitals and health centers in rural Kenya.

The kenyan ministry of health- department of standards and regulations sought to operationalize the kenya quality assurance model for health.To this end an integrated quality management system based on validated indicators derived from the kenya quality model for health (kqmh) was developed and adapted to the area of reproductive and maternal and neonatal health, implemented and analysed.Methods an integrated quality management (qm) approach was developed based on european practice assessment (epa) modified to the kenyan context.It relies on a multi-perspective, multifaceted and repeated indicator based assessment, covering the 6 world health organization (who) building blocks.The adaptation process made use of a ten step modified rand/ucla appropriateness method.To measure the 303 structure, process, outcome indicators five data collection tools were developed: surveys for patients and staff, a self-assessment, facilitator assessment, a manager interview guide.The assessment process was supported by a specially developed software (visotool®) that allows detailed feedback to facility staff, benchmarking and facilitates improvement plans.A longitudinal study design was used with 10 facilities (6 hospitals; 4 health centers) selected out of 36 applications.Data was summarized using means and standard deviations (sds).Categorical data was presented as frequency counts and percentages.Results a baseline assessment (t1) was carried out, a reassessment (t2) after 1.5 years.Results from the first and second assessment after a relatively short period of 1.5 years of improvement activities are striking, in particular in the domain 'quality and safety' (20.02%; p < 0.0001) with the dimensions: use of clinical guidelines (34,18%; p < 0.0336); infection control (23,61%; p < 0.0001).Marked improvements were found in the domains 'clinical care' (10.08%; p = 0.0108), 'management' (13.10%: p < 0.0001), 'interface in/out-patients' (13.87%; p = 0.0246), and in total (14.64%; p < 0.0001).Exemplarily drilling down the domain 'clinical care' significant improvements were observed in the dimensions 'antenatal care' (26.84%; p = 0.0059) and 'survivors of gender-based violence' (11.20%; p = 0.0092).The least marked changes or even a -not significant- decline of some was found in the dimensions 'delivery' and 'postnatal care'.Conclusions this comprehensive quality improvement approach breathes life into the process of collecting data for indicators and creates ownership among users and providers of health services.It offers a reflection on the relevance of evidence-based quality improvement for health system strengthening and has the potential to lay a solid ground for further certification and accreditation.

Journal: BMC health services research (2018)
Publication types: Journal Article;Multicenter Study;Research Support, Non-U.S. Gov't
The clinical and paraclinical correlates of employment status in multiple sclerosis.

To identify the clinical and paraclinical markers of employment status in multiple sclerosis (ms).Methods this was a cross-sectional sub-study investigating 1226 ms patients.To minimalized confounding effect, two groups of patients, matched by sex, age, and education, were selected: 307 patients with full time employment and 153 unemployed patients receiving disability pension.We explored associations between employment status and expanded disability status scale (edss), 25 foot walk test (25fwt), nine hole peg test (9hpt), brief international cognitive assessment for ms (bicams), paced auditory serial addition test (pasat), beck depression inventory (bdi), sloan charts (sloan), and brain volumetric mri measures.Results both groups differed significantly on all variables of interest (p < 0.001).In the univariate analyses, edss, sdmt (symbol digit modalities test) adjusted for bdi, 25fwt, and 9hpt best explained variability in vocational status.In multivariate analyses, the combination of edss, 25fwt, sdmt, bdi, and corpus callosum fraction (ccf) explained the greatest variability.As a next step, after patients were matched by edss, differences in sdmt, 25fwt (both p < 0.001), 9hpt, ccf, and t2 lesion volume were still present (all p < 0.005) between both groups.The best multivariate model consisted of sdmt, bdi, and t2 lesion volume.Conclusions edss, walking ability, cognitive performance, and mri volumetric parameters are independently associated with employment status.

Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2022)
Publication types: Journal Article
Mir-326 potentiates radiosensitivity of cervical squamous cell carcinoma through downregulating SMO expression in the Hedgehog signaling pathway.

Radiotherapy resistance affects the therapeutic effect of cervical squamous cell carcinoma (cscc).Smoothened (smo) is an anticancer target of the hedgehog (hh) pathway and its mutation is related to drug resistance.Objective to explore the roles of mi r-326 and smoothened (smo) on radiation resistance in patients with cervical carcinoma.Methods expression of mi r-326 and smo in cervical cancer tissue and radioresistant cell lines were analyzed.The radiation response with the expression of mi r-326 was evaluated in tissue and cells.Bioinformatics analysis and literature review were performed to explore the target of mi r-326.The regulation of mi r-326 to smo m rna was verified through the dual-luciferase reporter assay.Results patients with poor radiation response have lower mi r-326 and higher smo expression.Upregulation of mi r-326 decreased smo expression and its downstream proteins but does not affect the proliferation of cscc cells.The upregulation of mi r-326 increased radiation sensitivity of the cscc cell through downregulating smo and its downstream proteins in the hedgehog (hh) signaling pathway.Conclusions mi r-326 may predict the treatment response to radiation, and upregulating mi r-326 may improve the treatment response to radiation.

Journal: Genes & genomics (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Survival benefit of surgery in patients with clinical T4 esophageal cancer who achieved complete or partial response after neoadjuvant chemoradiotherapy or radiotherapy.

This study aimed to determine the long-term survival of patients with c t4 esophageal cancer (ec) and whether neoadjuvant chemoradiotherapy/radiotherapy plus surgery (n crt/rt + s) is superior to definitive crt(d crt)/rt in terms of survival in c t4 ec downstaged after n crt/rt.Summary background data treatment options for c t4 ec include d crt/rt and n crt/rt + s, but it is not clear whether the latter provides survival benefit in patients downstaged after n crt/rt.Methods from 2002 to 2017, 726 patients with c t4 esophageal squamous cell carcinoma (escc) were retrospectively analyzed.Patients achieving clinical complete response (c cr) or partial response (pr) after 4-week rt (median dose, 40.7 gy) and considered fit for surgery were offered esophagectomy.Of the 726 patients, 308 (42.4%) achieved c cr/pr, while 74 patients received subsequent surgery (n crt/rt + s group), 234 patients received d crt/rt.Results median follow-up was 58 months.The 3-year overall survival (os) and progression-free survival (pfs) rates for all patients were 33.3% and 35.6%, respectively.The corresponding os and pfs rates were 54.8% and 48.5% in the n crt/rt + s groupversus30.0% and 22.1% in the d crt/rt group (bothp< 0.0001).After adjusting the confounding variables with inverse probability of treatment weighting, the adjusted 3-year os rates were 50.4% in the n crt/rt + s groupversus50.8% in the d crt/rt group (p= 0.15).However, the adjusted 3-year pfs rates were significantly different between the two groups (49.0% andversus38.3%,p= 0.004).Postoperative complications occurred in 18 (24.3%) patients.Conclusion the long-term survival of c t4 escc was improved after the use of three-dimensional crt.In c t4, ec responded to n crt/rt, surgery improves pfs but not os.

Journal: Therapeutic advances in medical oncology (2022)
Publication types: Journal Article
2020-2021 Drug Updates in Solid Tumors.

During jadpro live virtual 2021, christine cambareri, pharm d, bcps, bcop, csp, briefed advanced practitioners on drugs and biologics that were approved for the treatment of solid tumors from late 2020 to late 2021, including their adverse event profiles.The trend of more oral dosage forms and the significant number of checkpoint inhibitors approved points towards changing treatment paradigms in the field.

Journal: Journal of the advanced practitioner in oncology (2022)
Publication types: Journal Article