syedzayyan/paper_mill_benchmark huggingface dataset:
Dapagliflozin Inhibits Ventricular Remodeling in Heart Failure Rats by Activating Autophagy through AMPK/mTOR Pathway

Heart failure (hf) is the end stage of heart disease caused by various factors which mainly involves ventricular remodeling (vr).In hf patients with reduced ejection fraction, dapagliflozin (dapa) reduced the risk of worsening hf or cardiovascular death.Thus, we attempted to clarify the specific role of dapa underlying hf progression.Methods.The hf rat model was established to mimic characteristics of hf in vivo.He staining assessed histopathological changes in left ventricular myocardial tissue of rats in each group.Elisa measured plasma anp and bnp levels of rats in each group.M-mode echocardiography detected cardiac function of rats in each group.Tunel staining detected apoptosis of infarct margin cells in myocardial tissue of rats in each group.Western blot detected levels of apoptosis-related proteins, autophagy-related proteins, and ampk/m tor-related proteins in myocardial tissue of rats in each group.Immunohistochemical staining detected caspase-3 or lc3b level in myocardial tissue of rats in each group.The hf cellular model was established to mimic characteristics of hf in vitro.Flow cytometry detected h9c2 cell apoptosis under different conditions.Western blot detected levels of apoptosis-related proteins, autophagy-related proteins, and ampk/m tor-related proteins in h9c2 cells under different conditions.Immunofluorescence detected caspase-3 or lc3b level in h9c2 cells under different conditions.Results.Dapa attenuated left vr and improved cardiac function in hf rats.Dapa attenuated cardiomyocyte apoptosis in hf rats.Dapa facilitated cardiomyocyte autophagy in hf rats via the ampk/m tor pathway.Dapa repressed hypoxia-induced h9c2 cell apoptosis by facilitating autophagy.Dapa repressed hypoxia-induced h9c2 cell apoptosis via the ampk/m tor pathway.Conclusion.Dapa suppresses ventricular remodeling in hf through activating autophagy via ampk/m tor pathway, which provides a potential novel insight for seeking therapeutic plans of hf.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Cuproptosis-Related Genes CDK1 and COA6 Involved in the Prognosis Prediction of Liver Hepatocellular Carcinoma

Liver hepatocellular carcinoma (lihc) is the most frequently seen type of primary liver cancer.Cuproptosis is a novel form of cell death highly associated with mitochondrial metabolism.However, the clinical impact and pertinent mechanism of cuproptosis genes in lihc remain largely unknown.Methods.From public databases, we systematically assessed common genes from lihc differentially expressed genes (degs) and cuproptosis-related genes using bioinformatics analysis.These common genes were then analyzed by enrichment analysis, mutation analysis, risk score model, and others to find candidate hub genes related to lihc and cuproptosis.Next, hub genes were determined by expression, clinical factors, immunoassay, and prognostic nomogram.Results.Based on 129 cuproptosis-related genes and 3492 lihc degs, we totally identified 21 downregulated and 18 upregulated common genes, and they were enriched in pathways, such as zinc ion homeostasis and oxidative phosphorylation.In the mutation analysis, missense mutation was the most common type in lihc patients, and the common gene f5 had the highest mutation frequency.After lasso-cox regression analysis and prognostic analysis, cdk1, abcb6, lcat, and coa6 were identified as prognostic signature genes.Among them, abcb6 and lcat were lowly expressed in tumors, and cdk1 and coa6 were highly expressed in tumors.In addition, abcb6 and lcat were negatively correlated with 6 kinds of immune cells, while cdk1 and coa6 were positively correlated with them.Cdk1 and coa6 were identified as hub genes related to lihc by cox regression analysis and prognostic nomogram.Conclusion.Cdk1 and coa6 are two oncogenes in lihc, which are involved in the molecular mechanism of cuproptosis and lihc.Besides, cdk1 and coa6 can positively regulate the expressions of immune cells in lihc.In clinical practice, they can be used as immunotherapeutic targets and prognostic predictors in lihc, which sheds new light on the scientific fields of cuproptosis and lihc.

Journal: Disease Markers (2023)
Publication types: Research Article;
Correlation between Sleep Time, Sleep Quality, and Emotional and Cognitive Function in the Elderly

To explore the relationship between sleep time, sleep quality, and emotional and cognitive function in the elderly.Methods .A total of 150 elderly patients over 65 years old who were admitted to our hospital from february 2019 to april 2021 were divided into a normal cognitive function group (mini‐mental state examination (mmse) score: illiteracy, &gt;17; primary school, &gt;20; and middle school and above, &gt;24; n = 86) and cognitive impairment group (mmse score: illiteracy, ≤17; primary school, ≤20; and middle school or above, ≤24; n = 64).The sleep quality was evaluated by the pittsburgh sleep quality index (psqi), and anxiety and depression were evaluated by hamilton anxiety scale (hama) and hamilton depression scale (hamd), respectively.The cognitive function between the two groups was compared via the montreal cognitive assessment (mo ca) score, visual spatial execution, and attention.Pearson correlation analysis was used to analyze the correlation between sleep quality, sleep time, and emotional and cognitive function.Results .In the comparison of sleep quality between the two groups, the total score of psqi, sleep quality, falling asleep time, sleep time, and sleep efficiency of patients with cognitive impairment were higher than those of patients with normal cognitive function ( p &lt; 0.05).There was no significant difference in the scores of hypnotic use and daytime dysfunction between the two groups, but the scores of nocturnal sleep disorders and ess in the cognitive impairment group were significantly higher than those in the normal group ( p &gt; 0.05).Compared between the two groups, the mo ca score, visual spatial execution, and attention in the cognitive impairment group were significantly lower than those in the normal group, and the difference was statistically significant ( p &lt; 0.05).The delayed recall in the cognitive impairment group was significantly higher than that in the control group ( p &lt; 0.05).There was no significant difference in orientation, naming, language, and abstract ability between the two groups ( p &gt; 0.05).The scores of hama and hamd in the cognitive impairment group were significantly higher than those in the normal group.Pearson correlation analysis was used to analyze the correlation between sleep therapy, sleep time, and the score of cognitive scale.The results showed that psqi was negatively correlated with mo ca and mmse, and ess was negatively correlated with mo ca and mmse.Pearson correlation analysis results indicated that psqi was positively correlated with hama and hamd, while ess was negatively correlated with hama and hamd.Conclusion .The sleep quality and sleep time of elderly patients are positively correlated with their cognitive function.The worse the sleep quality is, the worse their cognitive function is and the more serious their anxiety and depression are.In the course of clinical therapeutics, more attention should be paid to the sleep quality of elderly.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Correlation between Collateral Compensation and Homocysteine Levels in Patients with Acute Cerebral Infarction after Intravenous Thrombolysis Based on Medical Big Data

Homocysteine is an amino acid present in plasma, which is an important intermediate product in the metabolism of methionine and cysteine.Acute cerebral infarction (ci) is called acute ci of stroke.It is one of the most common diseases in neurology and has a serious impact, affecting people’s lives.This article is aimed at studying the effect of data mining algorithms based on medical big data and the improved apriori algorithm on the analysis of the correlation between collateral compensation and homocysteine levels in patients with acute ci.This article proposes that there are many factors in patients with acute ci, among which are collateral compensation and homocysteine levels that are not easily determined.From the data in the tables in the experiment of this article, it can be seen that the collateral circulation of patients with acute ci is 8%, and the collateral circulation of patients without acute ci is 35%.The results indicate that both collateral compensation and homocysteine levels affect patients with acute ci.The higher the homocysteine level, the greater the probability of acute ci, and the better the state of collateral circulation, the less likely it is to suffer from acute ci.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Control Optimization Design of Radio Frequency Identification Technology in IoT Express Logistics Distribution System

In order to solve the problems of high consumption cost and long transportation and distribution cycle of cross-border logistics, a control optimization design method of radio frequency identification technology in the express logistics distribution system of the internet of things is proposed.The details of the method are rfid positioning technology, laser ranging technology, rfid and laser fusion positioning feasibility analysis, and moving target state estimation.The experimental results show that when the phase shift threshold φ and the included angle of the antenna are 90°, the error can be reduced to 0.36 m, and the recognition rate can be increased to 94.8%.The simulation results show that, on the premise of meeting the customer’s expectation of timeliness, the actual logistics distribution cost is significantly lower than the customer’s expected logistics distribution cost, which verifies the effectiveness of the proposed method.

Journal: Journal of Control Science and Engineering (2022)
Publication types: Research Article;
Construction of Stomach Cancer Lesion Detection Combined with Drug Therapy Based on Artificial Intelligence

The number of stomach cancer (sc) patients is increasing sharply every year, and gastroscope is a common method to check stomach‐related diseases.A bulging lesion in the stomach is encountered during a gastroscopy.Due to the change in eating habits, the enhancement of health awareness, and the wide application of gastroscopy, the detection rate and cure rate of tumors have been significantly improved.This has certain clinical value for the early diagnosis and treatment of early sc.In this paper, based on the background of artificial intelligence, image segmentation technology is used to analyze and process the detection results of sc, so as to judge the effect of drug treatment.A total of 1408 gastric bulge lesions were investigated in 11023 patients during the one‐year period 2019‐2020.It also analyzed the age, lesion location, size, pathological type, and tumor detection results of 1408 patients.The experiment showed that among the 289 cases of submucosal bulging lesions, the detection rates of the young group, middle‐aged group, and elderly group were 14.9% (43/289), 67.5% (195/289), and 17.6% (51/289), respectively.Among them, middle‐aged people aged 41–65 have the highest detection rate.The incidence of gastric polyps was similar between different age groups.But with age, the rate of fundic gland polyps increases.The incidence of sc is not related to the age of the patient, but to its pathological type.The incidence of sc in middle‐aged and elderly people is significantly higher than that in young people.Sc is more common in the cardia, and gastrointestinal stromal tumors are most common with submucosal protrusion.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Construction of Pulmonary Embolism Prediction, Early Warning, and Precontrol MDT Collaborative Nursing Model Based on the Smith Model

The purpose of this study was to construct a multidisciplinary collaborative nursing model for pulmonary embolism risk prediction, early warning, and precontrol based on the smith model and evaluate the application effect and hospitalization satisfaction.2,037 patients hospitalized in the thoracic surgery department from june 1, 2019, to may 31, 2021, were selected as the research subjects.The control group received routine pulmonary embolism prevention management, while the experimental group received safe, case-based, and programmatic multidisciplinary intervention management based on the smith policy management model.The data were analyzed statistically.The experimental group’s extubation and hospitalization time, d-dimer value, incidence of deep vein thrombosis, and pulmonary embolism on the seventh day after surgery were lower than those in the control group, and the satisfaction of hospitalization in the experimental group was higher than that in the control group.The implementation of the multidisciplinary collaborative nursing model of pulmonary embolism risk prediction, early warning, and precontrol based on the smith model can promote the preventive effect of pulmonary embolism risk of surgical patients in our department and effectively improve the satisfaction of hospitalization, which is worthy for further promotion.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Construction of Prediction Model of Radiotherapy Set-Up Errors in Patients with Lung Cancer

This study intends to construct an error distribution prediction model and analyze its parameters and analyzes the boundary size of ctv extension to ptv, so as to provide a reference for lung cancer patients to control clinical set‐up errors and radiotherapy planning.Methods .The prior sbrt set‐up error data of 50 patients with lung cancer treated by medical linear accelerator were selected, the gaussian mixture model was adopted to construct the error distribution prediction model, and the model parameters were solved, based on which the emission boundary from ctv to ptv was calculated.Results .According to the analysis of the model parameters, the spatial distribution of set‐up errors is mainly concentrated in the direction of four central points ( μ 1 ~ μ 4 ), and the error is smaller in the vrt direction (‐0.991~2.808 mm) and lat direction (‐0.447~1.337 mm) and larger in the lng direction (‐1.065~4,463 mm).The possibility of offset of set‐up errors in μ 2 and μ 3 direction (0.4440, 02198) is greater than that of μ 1 and μ 4 (0.1767, 0.1595).The standard deviation of set‐up errors can reach 0.538 mm.The theoretical expansion boundary of ctv to ptv in vrt, lng, and lat can be calculated as 1.7963 mm, 2.3749 mm, and 0.6066 mm.Conclusion .The gmm gaussian mixture model can quantitatively describe and predict the set‐up errors distribution of lung cancer patients and can obtain the emission boundary of ctv to ptv, which provides a reference for radiotherapy set‐up errors control and tumor planning target expansion of lung cancer patients without sbrt.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Computational Intelligence Based Recurrent Neural Network for Identification Deceptive Review in the E-Commerce Domain

Most consumers depend on online reviews posted on e-commerce websites when determining whether or not to buy a service or a product.Moreover, due to the presence of fraudulent (deceptive) reviews, the fundamental problem in such reviews is not fully addressed.Thus, deceptive reviews present wrong and misguiding opinions that are harmful to consumers and e-commerce.People called fraudsters who intentionally write deceptive reviews to target and deceive potential consumers, as they target businesses that have a well-built reputation or fame for their personal promotion, create such reviews.Therefore, developing a deceptive review detection system is essential for identifying and classifying online product reviews as truthful or fake/deceptive reviews.The main objective of this research work is to analyze and identify online deceptive reviews in electronic product reviews in the amazon and yelp domains.For this purpose, two experiments were conducted individually.The first was executed on standard yelp product reviews.The second was performed on amazon product review datasets.For this dataset, we created and labeled it using a deceptiveness score calculated based on features extracted from the review text using the linguistic inquiry and word count (liwc) tool.These features were authenticity, negative words, comparing words negation words, analytical thinking, and positive words as well as the given rating value by a user.The recurrent neural network, bidirectional long short-term memory (rnn-blstm) model, was used to both datasets in order to conduct the evaluation.The application of this model was contingent upon the learning of words embedding of the review text.Finally, we evaluated the rnn-blstm model’s performance using the yelp and amazon datasets and compared the results.The results were 89.6% regarding testing accuracy for both datasets.From our experimental results, we observed that the liwc feature with word embedding in the review text provided better accuracy performance compared with other existing methods.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Comparison of Hepatectomy and Hemangiomas Stripping on Patients with Giant Hepatic Hemangiomas

To compare the value of a hepatectomy and hemangioma stripping on patients with giant hepatic hemangiomas.Methods .Seventy‐four patients with giant hepatic hemangiomas were retrospectively analyzed from data collected from their hepatobiliary surgeries performed from june 2010 to june 2015 at the people’s hospital of ningxia and the general hospital affiliated with ningxia medical university.The patients were divided into a hepatectomy group (37 patients) and a hemangioma‐stripping group (37 patients).Conditions of each group were compared before and after surgery and comprised of surgery duration, intraoperative blood loss, blood transfusion, duration of hepatic blood occlusion, and hospital stay.Any complications after surgery, such as pleural effusions, bile leakage, and abdominal hemorrhage, were also observed.Results .In the hemangioma‐stripping group, the surgery time was 2.38 ± 0.93 h, intraoperative blood loss was 889.19 ± 756.37, blood transfusion amount was 723.78 ± 801.14, the duration of hepatic blood occlusion 26.84 ± 17.30 min, and hospital stay was 16.19 ± 5.01 d.In the hepatectomy group, surgery time was 3.26 ± 1.16 h, intraoperative blood loss was 1551.35 ± 1755.88 m l blood transfusion amount was 1693.24 ± 2117.72 m l, duration of hepatic blood occlusion was 26.84 ± 17.30 min, and hospital stay was 16.19 ± 5.01 d.The difference between the groups was statistically significant ( p &lt; 0.05).The pleural effusion incident rate in the former group was lower than that of the latter group, and the difference was statistically significant.Conclusions .Hemangiomas stripping is an effective method by which to cure hepatic hemangioma, with the advantages being a relatively easy surgery with less patient trauma, rapid recovery, and fewer complications.This method should be used more often in clinical settings.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Comparison of Efficacy and Safety of TACE Combined with Microwave Ablation and TACE Combined with Cryoablation in the Treatment of Large Hepatocellular Carcinoma

To retrospectively evaluate the efficacy and safety of tace combined with microwave ablation (mwa) and tace combined with cryoablation (cra) in the treatment of large hepatocellular carcinoma.Methods.A retrospective analysis was performed on 81 patients with large hepatocellular carcinoma (tumor diameter 5~8 cm cm) who received tace combined with ablation in our hospital from february 2015 to february 2019.The study patients were divided into tace combined with mwa group (t-mwa, n = 41) and tace combined with cra group (t-cra, n = 40) according to the treatment plan.Overall survival (os) and progress free survival (pfs) were compared between the two groups, and complications were observed.Survival curves for os and pfs were constructed by the kaplan–meier method.Differences in overall survival were compared using the log-rank test.Results.There was no statistical difference in general conditions between the two groups of patients.The results showed that 30 (73.2%) patients in t-mwa group achieved objective response (or) and 39 (95.1%) patients achieved disease control (dc), compared with 24 (60.0%) patients in t-cra group who achieved objective response (or) and 37 (92.5%) patients who achieved disease control (dc).The median os was 19.2 months in the t-mwa group and 18.6 months in the t-cra group ( p = 0.64 ).The median pfs was 9.3 months in the t-mwa group and 12.3 months in the t-cra group ( p = 0.6 ).Univariate and multivariate analysis showed that portal vein tumor thrombus (pvtt), intrahepatic tumor diameter, and the number of tumor lesions were common prognostic factors for os and pfs.In terms of surgery-related complications and adverse reactions, abdominal pain and gastrointestinal reactions were observed in 13 (31.7%) and 11(26.8%) cases in the t-mwa group, while we observed 4 (10.0%) and 2 (5.0%) cases in the t-cra group, respectively.The difference between the two was statistically significant ( p &lt; 0.05 ).Conclusion.Tace combined with mwa and tace combined with cra were equally effective in the treatment of large hepatocellular carcinoma.Tace-cra can effectively reduce the incidence of abdominal pain and gastrointestinal reactions in patients.However, compared with tace-mwa, tace-cra is more likely to cause thrombocytopenia.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Comparison of Clinical Pregnancy Outcomes after Fresh and Frozen Embryo Transfer

S.To analyze the clinical outcomes of the patients who underwent fresh or frozen embryo transfer, as well as the neonatal outcomes.Methods.We conducted a retrospective analysis of women who underwent in vitro fertilization with fresh and frozen embryo transfer from january 2019 to january 2021.All of the included embryo transfers resulted in live births at ≥28 weeks of gestation.All of the patients were divided into two groups according to the assisted reproductive technique that was used (fresh embryo transfer group ( n = 101 ) and frozen embryo transfer group ( n = 125 )).Both groups were divided into subgroups based on a maternal age of ≥35 years.Result(s).Between the two groups, only the cesarean section rate was higher in the frozen transfer group, while no differences were shown for other outcomes.There were significant differences in the gestational hypertension and postpartum hemorrhage rates based on the subgroup comparison.No significant differences were detected in the offspring.Conclusions.Comparing fresh and frozen embryo transfers did not reveal any significant superiority.Venerable age exerts an apparent influence on pregnancy complications.Frozen embryo transfer is not always the best choice.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;