syedzayyan/paper_mill_benchmark huggingface dataset:
Impact Response of the Honeycomb Sandwich Structure with Different Poisson's Ratios.

The honeycomb sandwich structure is widely used in energy-absorbing facilities because it is lightweight, has a high specific stiffness and high specific strength, and is easy to process.It also has dynamic mechanical characteristics such as a high impact resistance and high energy absorption.To explore the influence of the poisson’s ratio on the local impact resistance, this paper compares and analyzes the local impact resistance of a series of honeycomb cores with different poisson’s ratios under the impact of a spherical projectile at different speeds.Three typical honeycombs with negative/zero/positive poisson ratios (re-entrant hexagon, semi-re-entrant hexagon, and hexagon) are selected to change the geometric parameters in order to have the same relative density and different poisson ratios (−2.76−3.63).The relative magnitude of the rear face sheet displacement is in the order of negative poisson’s ratio > zero poisson’s ratio > positive poisson’s ratio, which reveals that the honeycomb structure with the positive poisson’s ratio has better protection ability than the others.Finally, a dual-wall hexagonal honeycomb is proposed.The rear face sheet displacement of the dual-wall hexagonal honeycomb sandwich structure is reduced by 34.4% at 25 m/s compared with the hexagonal honeycomb, which has a better local impact resistance.

Journal: Materials (Basel, Switzerland) (2022)
Publication types: Journal Article
Biomarker-Informed Model-Based Risk Assessment of Organic Anion Transporting Polypeptide 1B Mediated Drug-Drug Interactions.

Quantitative prediction of drug-drug interactions (ddis) involving organic anion transporting polypeptide (oatp)1b1/1b3 inhibition is limited by uncertainty in the translatability of experimentally determined in vitro inhibition potency (half-maximal inhibitory concentration (ic50)).This study used an oatp1b endogenous biomarker-informed physiologically-based pharmacokinetic (pbpk) modeling approach to predict the effect of inhibitor drugs on the pharmacokinetics (pks) of oatp1b substrates.Initial static analysis with about 42 inhibitor drugs, using in vitro ic50values and unbound liver inlet concentrations (iin,max,u), suggested in vivo oatp1b inhibition risk for drugs with r-value (1+ iin,max,u/ic50) above 1.5.A full-pbpk model accounting for transporter-mediated hepatic disposition was developed for coproporphyrin i (cp-i), an endogenous oatp1b biomarker.For several inhibitors (cyclosporine, diltiazem, fenebrutinib, gdc-0810, itraconazole, probenecid, and rifampicin at 3 different doses), pbpk models were developed and verified against available cp-i plasma exposure data to obtain in vivo oatp1b inhibition potency-which tend to be lower than the experimentally measured in vitro ic50by about 2-fold (probenecid and rifampicin) to 37-fold (gdc-0810).Models verified with cp-i data are subsequently used to predict ddis with oatp1b probe drugs, rosuvastatin and pitavastatin.The predicted and observed area under the plasma concentration-time curve ratios are within 20% error in 55% cases, and within 30% error in 89% cases.Collectively, this comprehensive study illustrates the adequacy and utility of endogenous biomarker-informed pbpk modeling in mechanistic understanding and quantitative predictions of oatp1b-mediated ddis in drug development.

Journal: Clinical pharmacology and therapeutics (2022)
Publication types: Journal Article
Drawing the baseline of trace element levels in the vulnerable Mediterranean osprey Pandion haliaetus: variations by breeding location, habitats, and egg components.

Due to its peculiarity to accumulate environmental contaminants, the osprey pandion haliaetus is a sentinel species for the biomonitoring of contaminants in aquatic ecosystems.Despite this, no information on trace element concentration exists for the mediterranean area, where relict and vulnerable osprey populations exist.We evaluated the geographical patterns of heavy metals and selenium in osprey eggs from three different populations of the mediterranean basin (balearic islands, corsica, and tuscany), to identify any possible contaminant sources.Pattern of metal concentration followed the order: fe > zn > cu > se > hg > pb > cd.Differences in contaminant concentrations between habitats and among egg components were found.Egg content and inner membrane showed higher mercury levels (1.06 ± 0.89 and 0.67 ± 0.62 mg/kg dw, respectively) than those recorded in the eggshell.Mercury concentration was ca.Two times higher in marine than in wetland samples, and even higher (3.6 times) when referred to the eggshell.Cu, fe, zn, and se had higher concentration in the inner membrane.We stress how the choice of the biological material can have significant implications for the correct evaluation of contamination.Our study represents a first regional scale survey for the vulnerable mediterranean osprey populations and provides baseline data for their long-term biomonitoring.

Journal: Environmental science and pollution research international (2020)
Publication types: Journal Article
Endovascular Therapy for Cerebral Vein Thrombosis: A Propensity-Matched Analysis of Anticoagulation in the Treatment of Cerebral Venous Thrombosis.

Endovascular treatment (evt) for cerebral vein thrombosis (cvt) has not been proven to be more effective than anticoagulation based on recent results of the thrombolysis or anticoagulation for cerebral venous thrombosis (to-act) randomized clinical trial.Objective to compare outcomes of evt vs medical management in cvt.Methods we compared evt vs medical management in a retrospective multinational cohort of consecutive patients with cvt across 4 countries (usa, italy, switzerland, and new zealand) and 27 sites (2015-2020), using propensity score matching (psm) and inverse probability treatment weighting (iptw), and meta-analyzed these results with the to-act trial.The primary outcome was excellent functional outcome (modified rankin scale [m rs] 0-1) at 90 days.Results of the 987 patients, the mean age was 45.7 ± 16.9 years and 79 (8%) underwent evt.With psm (n = 124), there were no major differences in clinical or imaging features between groups other than a higher proportion of female patients receiving evt (81% vs 65%, p = .04).There was no difference in the primary outcome with psm (odds ratio [or] 1.48, 95% ci, 0.55-3.96) or iptw (or 1.02, 95% ci, 0.34-3.06).Evt was associated with a higher 90-day shift in modified rankin scale (or 2.00, 95% ci, 1.01-3.98) and mortality with iptw (or 4.60, 95% ci, 1.10-19.23) but no other differences in secondary outcomes with psm or iptw.A meta-analysis of primary and secondary outcomes from to-act and psm patients from anticoagulation in the treatment of cerebral venous thrombosis also showed no significant association with evt in primary or secondary outcomes.Conclusion in this large observational cohort, there was no evidence of benefit with evt for cvt.These findings corroborate the results from the to-act trial.

Journal: Neurosurgery (2022)
Publication types: Journal Article;Meta-Analysis
Psychiatric Comorbidity in Mexican Adolescents with a Diagnosis of Eating Disorders Its Relationship with the Body Mass Index.

The prevalence of comorbid psychiatric disorders among patients with eating disorders (ed) is higher than the general population.Individuals diagnosed with eating disorders have changes in their body mass index which could promote severe metabolic disruptions.This study aimed (1) to report the prevalence of comorbid psychiatric disorders among a mexican adolescent sample diagnosed with eating disorders, (2) to compare our results with the prevalence of psychiatric disorders reported from a national survey of mental health of adolescents, (3) to compare the presence of psychiatric comorbidities between ed diagnoses, and (4) to explore the relationship of these comorbidities with the body mass index.In the study, we included 187 mexican adolescents diagnosed with eating disorders.The psychiatric comorbidities were evaluated using the mini international neuropsychiatric interview for children/adolescents, and a revised questionnaire on eating and weight patterns.We found that 89% of the mexican adolescents diagnosed with ed had another psychiatric comorbidity.Major depressive disorder (52.40%) and suicide risk (40%) were the most prevalent comorbidities.Attention and deficit hyperactivity disorder (adhd) prevalence was different between ed diagnosis, and adolescents with binge-eating disorder and adhd had the higher body mass index.Our results showed that in this sample of mexican adolescents, the presence of comorbidities could impact body mass index.This emphasizes the importance that clinicians take into consideration the presence of psychiatric comorbidities to achieve an integrative treatment for adolescents diagnosed with ed.

Journal: International journal of environmental research and public health (2021)
Publication types: Journal Article
Gender Self-Confidence as a Protective Factor for Suicide Risk: Analysis of the Sample of Lithuanian Men.

Along with other suicide risk factors, masculinity has been analyzed as an important subject for suicidal behavior in men.This study examines masculinity as a gender self-confidence which is the intensity of an individual's belief that he meets his standards for masculinity.We use hoffman and her colleague's concept, which provides two theoretical constructs as elements of gender self-confidence: gender self-definition and gender self-acceptance.Gender self-definition relates to how salient masculinity is in one's identity; gender self-acceptance relates to how positively one views his masculinity.Methods the quantitative research approach was applied in the study.The survey with a nonprobability quota sampling design was implemented to collect the data.The sample consisted of 562 lithuanian men from various age groups and regions.The age of participants varied from 18 to 92 years (m= 42.99,sd= 17.18); 40.9% of men were from cities, 28.1% from towns, and 30.8% from rural locations.We used the hoffman gender scale to measure gender self-definition and gender self-acceptance.Suicide risk was estimated with the suicide behavior questionnaire-revised.Patient health questionnaire-2 was used to measure depression symptoms as a controlled variable.Statistical analysis of regression and moderation was used to test the hypothesis.Results higher gender self-definition and higher gender self-acceptance were associated with lower suicide risk.The moderation analysis showed that in men with relatively low gender self-definition, the effect of gender self-acceptance on suicidality was larger than in men with high or moderate gender self-definition.Discussion we conclude that a stronger gender self-confidence is an important protective factor in male suicide risk.Both, a smaller part of masculinity in one's identity and a negative view of one's masculinity have a cumulative effect on increased suicide risk.The findings have been discussed in accordance with the theories that explain suicidal behavior through the lenses of self-concept.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article
Kissing genetic MS risk loci to life.

Multiple sclerosis (ms) is an inflammatory autoimmune demyelinating disease of the central nervous system (cns) [1].Its debilitating effects on sensory, motor, autonomic, and neurocognitive functions affect primarily young adults, especially women (two to three times more frequent than in men), and is most frequent in northern countries, affecting more than 150 individuals of every 100,000 inhabitants e.g.In canada and the scandinavian countries.The development of this often initially relapsing/remitting and later progressive disease is associated with genetic and environmental risk factors [1, 3].The major histocompatibility complex (mhc) class ii gene locus is by far the most prominent genetic risk factor, and altered immune responses to the epstein barr virus (ebv), the causative infectious agent of most cases of infectious mononucleosis or "kissing disease", have in recent years emerged as the most prominent environment induced risk factors for ms [1].Interestingly, particularly infectious mononucleosis as symptomatic primary ebv infection, caused by a lymphocytosis of mainly lytic ebv antigen specific cd8+t cells, and elevated antibody responses against ebv have been found to synergize with the ms associated mhc class ii molecule hla-drb1*1501 to increase ms risk seven- to fifteen-fold, respectively [1].Moreover, ebv infection seems to precede ms onset by several years in nearly all patients.Thus, ebv infection currently appears as a prerequisite for ms development that increases the risk for this autoimmune disease in genetically susceptible individuals.

Journal: EBioMedicine (2021)
Publication types: Journal Article
Removal of Copper (II) by Biochar Mediated by Dissolved Organic Matter.

The effects of humic acid (ha) and fulvic acid (fa) on cu2+adsorption on biochar were investigated, with mechanisms confirmed by excitation-emission matrix spectroscopy, fourier transform infrared spectroscopy, and scanning electron microscopy.Ha loading enhanced cu2+adsorption on biochar, with the maximum enhancement of 55.0% occurring at an ha loading of 100 mg-c/l.The adsorbed ha introduced many additional functional groups to biochar, thus enhancing cu2+adsorption, which decreased at ha concentrations >100 mg-c/l due to self-association of ha at high loading concentrations.In contrast, fa loading caused no enhancement on cu2+adsorption on biochar.Fa was adsorbed through h-bonding with the functional groups of biochar, which set up a competition with cu2+for adsorption on biochar.The functional groups occupied by adsorbed fa were offset by the newly introduced functional groups of fa, thus there was no net increase in the amount of cu2+adsorption upon fa loading.These findings imply that, because of the enhanced adsorption of ha-loaded biochar, the amount of cu2+immobilized would increase by 28.2% for mature compost and 31.9% for fresh compost if there exist interaction between biochar and ha compared with the amounts immobilized by non-interactive ha and biochar.

Journal: Scientific reports (2017)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Television airings of U.S. federal COVID-19 public service announcements in 2020 were associated with market-level political orientation, not COVID-19 rates.

Televised public service announcements were one of the ways that the u.s.Federal government distributed health information about the covid-19 pandemic to americans in 2020.However, little is known about the reach of these campaigns or the populations who might have been exposed to the information these ads conveyed.We conducted a descriptive analysis of federally-affiliated public service announcement airings to assess where they were aired and the market-level social and demographic characteristics associated with the airings.We found no correspondence between airings and covid-19 incidence rates from march to december 2020, but we found a positive association between airings and the democratic vote share of the market, adjusting for other market demographic characteristics.Our results suggest that psas may have contributed to divergent exposure to health information among the u.s.Public during the first year of the covid-19 pandemic.

Journal: PloS one (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Efficient, Selective CO2Photoreduction Enabled by Facet-Resolved Redox-Active Sites on Colloidal CdS Nanosheets.

Advances in nanotechnology have enabled precise design of catalytic sites for co2photoreduction, pushing product selectivity to near unity.However, activity of most nanostructured photocatalysts remains underwhelming due to fast recombination of photogenerated electron-hole pairs and sluggish hole transfer.To address these issues, we construct colloidal cd s nanosheets (nss) with the large basal planes terminated by s2-atomic layers as intrinsic photocatalysts (cd s-s2-nss).Experimental investigation reveals that the s2-termination endows ultrathin cd s-s2-nss with facet-resolved redox-catalytic sites: oxidation occurs on s2--terminated large basal facets and reduction happens on side facets.Such an allocation of redox sites not only promotes spatial separation of photoinduced electrons and holes but also facilitates balanced extraction of holes and electrons by shortening the hole diffusion distance along the (001) direction of the ultrathin nss.Consequently, the cd s-s2-nss exhibit superb performance for photocatalytic co2-to-co conversion, which was verified by the isotope-labeled experiments to be a record-breaking performance: a co selectivity of 99%, a co formation rate of 2.13 mol g-1h-1, and an effective apparent quantum efficiency of 42.1% under the irradiation (340 to 450 nm) of a solar simulator (am 1.5g).The breakthrough performance achieved in this work provides novel insights into the precise design of nanostructures for selective and efficient co2photoreduction.

Journal: Journal of the American Chemical Society (2022)
Publication types: Journal Article
Structural analysis of phosphatidylinositol 4-kinase IIIβ (PI4KB) - 14-3-3 protein complex reveals internal flexibility and explains 14-3-3 mediated protection from degradation in vitro.

Phosphatidylinositol 4-kinase iiiβ (pi4kb) is responsible for the synthesis of the golgi and trans-golgi network (tgn) pool of phosphatidylinositol 4-phospahte (pi4p).Pi4p is the defining lipid hallmark of golgi and tgn and also serves as a signaling lipid and as a precursor for higher phosphoinositides.In addition, pi4kb is hijacked by many single stranded plus rna (+rna) viruses to generate pi4p-rich membranes that serve as viral replication organelles.Given the importance of this enzyme in cells, it has to be regulated.14-3-3 proteins bind pi4kb upon its phosphorylation by protein kinase d, however, the structural basis of pi4kb recognition by 14-3-3 proteins is unknown.Here, we characterized the pi4kb:14-3-3 protein complex biophysically and structurally.We discovered that the pi4kb:14-3-3 protein complex is tight and is formed with 2:2 stoichiometry.Surprisingly, the enzymatic activity of pi4kb is not directly modulated by 14-3-3 proteins.However, 14-3-3 proteins protect pi4kb from proteolytic degradation in vitro.Our structural analysis revealed that the pi4kb:14-3-3 protein complex is flexible but mostly within the disordered regions connecting the 14-3-3 binding site of the pi4kb with the rest of the pi4kb enzyme.It also predicted no direct modulation of pi4kb enzymatic activity by 14-3-3 proteins and that 14-3-3 binding will not interfere with pi4kb recruitment to the membrane by the acbd3 protein.In addition, the structural analysis explains the observed protection from degradation; it revealed that several disordered regions of pi4kb become protected from proteolytical degradation upon 14-3-3 binding.All the structural predictions were subsequently biochemically validated.

Journal: Journal of structural biology (2017)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Cellular Lactate Spectroscopy Using 1.5 Tesla Clinical Apparatus.

Cellular lactate is a key cellular metabolite and marker of anaerobic glycolysis.Cellular lactate uptake, release, production from glucose and glycogen, and interconversion with pyruvate are important determinants of cellular energy.It is known that lactate is present in the spectrum of neoplasms and low malignancy (without necrotic lesions).Also, the appearance of lactate signals is associated with anaerobic glucose, mitochondrial dysfunction, and other inflammatory responses.The aim of this study was the detection of lactate in cell cultures with the use of proton magnetic resonance (1h mrs) and a 1.5 tesla clinical apparatus (mr optima 360), characterized as a medium-field system.In this study, selected metabolites, together with cellular lactate, were identified with the use of an appropriate protocol and management algorithm.This paper describes the results obtained for cancer cell cultures.This medium-field system has proven the possibility of detecting small molecules, such as lactate, with clinical instruments.1h mrs performed using clinical mr apparatus is a useful tool for clinical analysis.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article
Cyclodipeptides: From Their Green Synthesis to Anti-Age Activity.

Cyclodipeptides (cdps) or diketopiperazines (dkps) are often found in nature and in foodstuff and beverages and have attracted great interest for their bioactivities, biocompatibility, and biodegradability.In the laboratory, they can be prepared by green procedures, such as microwave-assisted cyclization of linear dipeptides in water, as performed in this study.In particular, five cdps were prepared and characterized by a variety of methods, including nmr and esi-ms spectroscopies and single-crystal x-ray diffraction (xrd), and their cytocompatibility and anti-aging activity was tested in vitro, as well as their ability to penetrate the different layers of the skin.Although their mechanism of action remains to be elucidated, this proof-of-concept study lays the basis for their future use in anti-age cosmetic applications.

Journal: Biomedicines (2022)
Publication types: Journal Article
Self-assembly of highly ordered micro- and nanoparticle deposits.

The evaporation of particle-laden sessile droplets is associated with capillary-driven outward flow and leaves nonuniform coffee-ring-like particle patterns due to far-from-equilibrium effects.Traditionally, the surface energies of the drop and solid phases are tuned, or external forces are applied to suppress the coffee-ring; however, achieving a uniform and repeatable particle deposition is extremely challenging.Here, we report a simple, scalable, and noninvasive technique that yields uniform and exceptionally ordered particle deposits on a microscale surface area by placing the droplet on a near neutral-wet shadow mold attached to a hydrophilic substrate.The simplicity of the method, no external forces, and no tuning materials' physiochemical properties make the present generic approach an excellent candidate for a wide range of sensitive applications.We demonstrate the utility of this method for fabricating ordered mono- and multilayer patternable coatings, producing nanofilters with controlled pore size, and creating reproducible functionalized nanosensors.

Journal: Nature communications (2022)
Publication types: Journal Article