syedzayyan/paper_mill_benchmark huggingface dataset:
The Effect of lncRNA SNHG3 Overexpression on Lung Adenocarcinoma by Regulating the Expression of miR-890

The lnc rna small nucleolar host gene 3 (snhg3) was discovered to play an important role in the occurrence and development of lung adenocarcinoma (luad).However, the underlying molecular mechanism of snhg3 in luad remains unclear.In the present study, snhg3 expression levels in luad tissues and cell lines were analyzed using reverse transcription-quantitative pcr.The effects of snhg3 on the proliferation, apoptosis, migration, and invasion of luad cells were determined using cell counting kit-8, colony formation, flow cytometry, wound healing, and transwell chamber assays, respectively.The specific underlying mechanism of snhg3 in luad was investigated using bioinformatics analysis and a dual luciferase reporter assay.The results revealed that snhg3 expression levels were downregulated in luad tissues and cell lines.Functionally, snhg3 overexpression suppressed the proliferation, migration, and invasion of luad cells, while promoting apoptosis.Mechanistically, micro rna- (mi r-) 890 was identified as a potential target of snhg3, and its expression was negatively regulated by snhg3.Notably, snhg3 was found to promote luad progression by targeting mi r-890.In conclusion, the findings of the present study revealed that lnc rna snhg3 promoted the occurrence and progression of luad by regulating mi r-890 expression.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Antitumor Effects of 10058-F4 and Curcumin in Combination Therapy for Pancreatic Cancer In Vitro and In Vivo

S of the study.In vitro and in vivo evaluation of the antipancreatic cancer effects and benefits of the 10058-f4 and curcumin combination therapy.Background.Pancreatic cancer (pc) stands out as one of the most lethal cancers.Due to late diagnosis, only a fraction of patients can be resected.Although it still has significant adverse effects and poor results, the treatment is connected with better overall survival than the prior treatment.Thus, new alternative therapy for advanced pc is needed.Materials/methods.The impact of 10058-f4 and curcumin combination therapy on apoptosis and cell growth in sw1990 pancreatic cancer cells were determined in vitro using the cck-8 assay and flow cytometry of annexin v-fitc/pi, and the in vivo antitumor effect was determined utilizing sw1990-bearing pancreatic tumor mouse models induced by subcutaneous implantation.Results.At concentrations of (10 mol/l+2 mol/l), 10058-f4+curcumin obtained the highest rate of sw1990 cell death, and they had a beneficial effect on sw1990 pancreatic tumor-bearing animals.Furthermore, c-myc, akt phosphorylation, and the expression of apoptosis-related molecular were reduced, and the combination therapy modified the expression of apoptosis-related molecular.Conclusions.In vitro and in vivo, the combination of 10058-f4 plus curcumin has antipancreatic cancer actions that are substantially effective.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
An Association between EMX2 Variations and Mayer-Rokitansky-Küster-Hauser Syndrome: A Case-Control Study of Chinese Women

Mayer-rokitansky-küster-hauser (mrkh) syndrome is characterized by congenital malformations of müllerian structures, including the uterus and upper two-thirds of the vagina in women.Until now, the etiology of this disease has remained unknown.We hypothesized that emx2 (the human homologue of drosophila empty spiracles gene (2) might be a candidate gene for mrkh syndrome because it plays an important role in the development of the urogenital system.Through sequence analysis of emx2 in forty patients with mrkh syndrome and one hundred and forty healthy women controls, we identified eleven variations in total.Four novel variations were only found in mrkh patients, and seven single nucleotide polymorphisms were identified in both patients and controls.In silico analyses suggested that the novel variations in the 5′utr (untranslated region) and 3′utr might affect transcriptional activity of the emx2 promoter or posttranscriptional processing.In conclusion, our study suggests an association between noncoding variations in the emx2 gene and mrkh syndrome in a chinese han population.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Application of 64-Slice Spiral CT Imaging Technology Based on Smart Medical Augmented Reality in the Diagnosis of Foreign Bodies in the Respiratory Tract in Children

A foreign body in the respiratory tract is one of the common accidental injuries of children in our country, and is usually an important and serious event.Injuries caused by foreign substances in the respiratory tract seriously threaten the health and life of children in korea and are a great challenge for parents as well.In the process of diagnosis of foreign bodies in the respiratory tract, there is often missed diagnosis or serious complications.Therefore, this article proposes the application of 64-slice spiral ct imaging technology based on smart medical augmented reality in the diagnosis of foreign bodies in the respiratory tract in order to improve the diagnosis of foreign bodies in the respiratory tract, provide help with treatment to improve the prognosis of foreign bodies in the respiratory tract, and reduce the incidence of foreign bodies in the respiratory tract.In this paper, 36 children underwent a 64-slice spiral ct scan of their lungs, and images were transferred to a workstation for multiplanar reconstruction, minimal density projection, three-dimensional volume reconstruction imaging, and ct virtual endoscopic reconstruction, the location, shape, size, and size of the foreign body in contrast with adjacent structural lesions and lesions seen during surgery.Experiments have shown that the left bronchial granulation accounted for 27.3%, the right bronchial granulation 18.75%, the main tracheal granulation 28.6%; there was no significant difference between the left and right bronchial granulation ( p &gt; 0.05), while the main tracheal granulation and bilateral bronchial granulation there are significant differences between the shape distributions (p &lt; 0.05).This shows that ct imaging technology has enabled more patients to avoid surgical operations and ensure that the spiral computer can bring the greatest benefits to children.A 64-slice spiral ct scan can diagnose foreign bodies in the child’s respiratory tract.The detection rate is high and the diagnostic failure rate is low.The diagnostic rationale provides a reference for early clinical treatment.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
An Empirical Study on the Employment Monitoring and Early Warning Mechanism of Medical Graduates in Universities with Big Data and Complex Computing System

Based on the management of big data, the analysis and forecast of the employment demand cycle business situation studied in this article is based on the employment cycle theory and a complete set of employment monitoring, employment evaluation, employment forecasting, and policy selection theories and strategies developed around the employment cycle fluctuations, a specific employment phenomenon.First, systematically evaluate the current state of the employment demand boom, appropriately reflect the hot and cold degree of the employment demand boom, and provide necessary information for the government’s regulatory measures, content, and timing.Secondly, it reflects the regulatory effects of graduate employment monitoring, judging whether graduate employment monitoring measures are properly applied, whether they have the effect of smoothing out employment fluctuations, and promoting the country’s employment demand; in addition, business decision makers can take advantage of the employment demand boom, by monitoring the information provided by the early warning system and timely foreseeing the upcoming macrocontrol measures, so that enterprises’ labor adjustments can adapt to the government’s regulatory measures.At the same time, the model proposes a prosperity index method for monitoring and early warning of the employment demand cycle.After selecting and dividing three types of prosperity indicators, the di index reflecting the trend of the prosperity change and the ci index reflecting the strength of the prosperity change are calculated and constructed.The national employment demand boom monitoring and early warning signal system predicts the trend of the employment boom cycle outside the sample period.The experimental results show that the cyclic prosperity forecast results are consistent not only with the national employment demand prosperity in recent months, but also with the use of the structural measurement arima (p, d, q) model.The alertness value is close, indicating that this indicator system has a good effect on the national employment demand boom monitoring and early warning.

Journal: Discrete Dynamics in Nature and Society (2021)
Publication types: Research Article;
Bevacizumab Combined with Intensity-Modulated Radiation Therapy on Cognitive and Coagulation Function in Postoperative Glioma Patients

To examine the influences of bevacizumab combined with intensity-modulated radiation therapy (imrt) on postoperative brain glioma, particularly its impact on coagulation function and cognitive function, the complete clinical data of 156 patients undergoing glioma surgery in the neurosurgery department of our hospital between march 2015 and october 2018 were retrospectively analyzed.All patients underwent glioma surgery and were then assigned to the observation group (obs group, n = 79, received bevacizumab combined with imrt) or the control group (con group, n = 77, received imrt without bevacizumab) for analysis during postoperative treatment.The patients' short-term efficacy was evaluated, and their serum markers and coagulation function were compared, as well as the cognitive function, the occurrence of adverse reactions during treatment, the karnofsky performance status (kps) score, and quality of life after treatment.Patients' survival was followed up within 2 years after surgery.The obs group showed a notably higher clinical remission rate and clinical control rate (dcr) than the con group after treatment.The obs group showed notably lower levels of interleukin-2 (il-2), vascular endothelial growth factor (vegf), il-6, and epidermal growth factor (egf), experienced notably shorter prothrombin time (pt) and activated partial thromboplastin time (aptt), and showed higher fibrinogen (fib) and d-dimer (d-d) levels than con group.The obs group showed notably better cognitive function, kps score, and quality of life than the con group, but no notable difference was observed between them in the incidence of adverse reactions (p &gt; 0.0500).The survival rates in the obs group were higher than in the con group.For patients with glioma, postoperative bevacizumab combined with imrt delivers substantially higher clinical efficacy by lowering serum marker levels and improving cognitive function without significantly affecting coagulation function.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Atherosclerosis Vascular Endothelial Secretion Dysfunction and Smooth Muscle Cell Proliferation

Atherosclerosis is a chronic inflammatory disease of the arterial wall and the main cause of cardiovascular disease and cerebrovascular disease.In recent years, the mortality rate of atherosclerotic diseases has become higher and higher.This article aims to study the dysregulation of atherosclerotic vascular endothelial secretion and smooth muscle cell proliferation, and put forward and practice the pathological research of atherosclerotic disease.This article describes in detail atherosclerosis, endothelial dysfunction, and smooth muscle cell proliferation, and studies the causes of atherosclerosis.Research results indicate that atherosclerotic vascular endothelial dysfunction also has a great influence on the proliferation of smooth muscle cells.Many genes and environmental factors can regulate the functions of endothelial cells, vascular smooth muscle cells, and mononuclear macrophages and affect the formation of atherosclerosis.At the same time, diabetes, hypertension, hyperlipidemia, obesity, etc.Are the main causes of atherosclerosis.The number of patients with cardiovascular and cerebrovascular diseases dying from atherosclerosis in the country is increasing, and the proportion is close to 30%.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Study on Correlation between Body Cell Mass Index and Cognitive Impairment in Hemodialysis Maintaining Patients: A Cross-Sectional Study

To investigate the relationship between body cell mass index (bcmi) and cognitive impairment in maintaining hemodialysis (mhd) patients.Methods.We collected the general materials, laboratory indexes, and physical measurement indexes of patients undergoing maintenance hemodialysis in hemodialysis centers of 20 tertiary and tertiary general hospitals in guizhou province from june to september 2020.The body composition was measured by bioelectrical impedance method, and the bcmi value was calculated.The subjects were divided into normal cognitive function group (score ≥27), mild cognitive impairment group (score 23–26), and severe cognitive impairment group (score &lt;23).Two groups of people with normal cognitive function and cognitive impairment with similar baseline data (gender, age, and education) were obtained by propensity score matching (psm).Results.A total of 2008 subjects were included in this study, including 467 cases (23.3%) in the cognitive impairment group.A total of 814 cases were accurately matched after psm.Multivariate logistic regression analysis showed that the incidence risk of the bcmi q1 group was 8.99 times higher than that of the q4 group (95% ci: 5.74 ∼ 14.09, p &lt; 0.001 ).Roc curve analysis showed that the best threshold of bcmi for predicting cognitive impairment in mhd patients was 9.05, the sensitivity and specificity were 71.5% and 62.7%, respectively, and the area under the curve was 0.713 (95% ci: 0.678 ∼ 0.748, p &lt; 0.001 ).Conclusions bcmi is related to cognitive impairment in mhd patients and has predictive value for the onset of cognitive impairment in mhd patients.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Clinical Study;Research Article;
Innovation Clustering Analysis of Accurate Support Path for CSE under the Environment of Big Data

Facing the severe employment situation and social environment, the employment of college students has become a very important issue.The big data analysis plays a positive role in entrepreneurship, which can not only improve the success rate of entrepreneurial path selection, but also accumulate a lot of innovative practical experience for college students.Based on the importance of big data technology for entrepreneurial path, this paper proposes an innovative model of accurate support path for college students’ entrepreneurship (cse), in which the k ‐means algorithm is applied to the analysis of entrepreneurial support path.Finally, this paper makes an experimental analysis on the model, and the results show that k ‐means can greatly reduce the computational complexity of the algorithm, and the precision, recall, and f parameter of the model can be effectively improved.The model is of great significance in improving the feasibility of college students’ entrepreneurial support policies.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
An Exploration of the Environment, Composition, and Transmission of the Development of Local Theater and Music in the Natural Environment and Folklore Activities of Tea Picking

The spread and urbanization of modern culture have led to a crisis in the development and inheritance of traditional culture, coupled with the limitations of traditional drama itself, and local opera has gradually disappeared from the daily life of the local people.Through the analysis of the tea opera cases and the development environment and inheritance of local operas, the paper tries to solve the inheritance dilemma it faces and provides a new perspective and demonstration for the development and inheritance research of bobai jinan tea opera, which is of great significance to the development and propaganda of traditional chinese culture.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
Structural, Optical, Antibacterial, and Anticancer Properties of Cerium Oxide Nanoparticles Prepared by Green Synthesis Using Morinda citrifolia Leaves Extract

Currently, new advancements in the area of nanotechnology opened up new prospects in the field of medicine that could provide us with a solution for numerous medical complications.Although a several varieties of nanoparticles is being explored to be used as nanomedicines, cerium oxide nanoparticles (ce o 2 nps) are the most attractive due to their biocompatibility and their switchable oxidation state (+3 and +4) or in other words the ability to act as prooxidant and antioxidant depending on the p h condition.Green synthesis of nanoparticles is preferred to make it more economical, eco‐friendly, and less toxic.The aim of our study here is to formulate the ce o 2 nps (ce o 2 nps) using morinda citrifolia (noni) leaf extract and study its optical, structural, antibacterial, and anticancer abilities.Their optical and structural characterization was accomplished by employing x‐ray diffractography (xrd), tem, edax, ftir, uv‐vis, and photoluminescence assays.Our ce o 2 nps expressed strong antibacterial effects against gram‐positive s.Aureus and s.Pneumonia in addition to gram‐negative e.Coli and k.Pneumonia when compared with amoxicillin.The anticancer properties of the green synthesized ce o 2 nps against human acute lymphoblastic leukemia (all) molt‐4 cells were further explored by the meticulous study of their ability to diminish cancer cell viability (cytotoxicity), accelerate apoptosis, escalate intracellular reactive oxygen species (ros) accumulation, decline the mitochondria membrane potential (mmp) level, modify the cell adhesion, and shoot up the activation of proapoptotic markers, caspase−3, −8, and −9, in the tumor cells.Altogether, the outcomes demonstrated that our green synthesized ce o 2 nps are an excellent candidate for alternative cancer therapy.

Journal: Bioinorganic Chemistry and Applications (2022)
Publication types: Research Article;
Design and Implementation of Balance Ability Assessment Training System for Special Children Based on Education Cloud Integration

Many children with special needs have body balance disorders, which will not only bring inconvenience to their daily lives but also have a certain impact on their spirits, making them insecure.It will lead to a decline in their social skills, which will also seriously affect their study and work as well as reduce their quality of life.The purpose of this paper is to design and discuss a system for evaluating and training the balance ability of children with special needs based on the integration of education cloud.The balance ability evaluation module of the system performs a series of calculations on the projection coordinates of the center of gravity of the human body in various postures, and the obtained parameter values are the basis of the evaluation.This paper analyzes the role of education cloud integration in the evaluation of balance ability of special children, evaluates and trains the balance ability of special children, and verifies the feasibility of the balance ability evaluation and training system for special children.This study found that in a feasibility trial evaluating the balance ability of children with special needs, the balance stability of the tested children was improved, and the overall balance ability improved by 60%.The balance ability evaluation training system developed in this paper can effectively improve the independent standing ability of young children.Children over the age of 4 do not have any difficulties in understanding and mastering movements, and training difficulties for children are also applicable.At the same time, the results of these exercises also showed that this kind of exercise can help children maintain their balance.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
The Research on Intelligent Measurement Terminal of Water-Saving Irrigation Based on RN2026 Microcontroller

Water‐saving irrigation technology has been studied for many years, but due to insufficient investment in research and development of irrigation equipment, it cannot be effectively promoted and applied.In order to improve the water use efficiency of farmland irrigation, the automatic monitoring of groundwater level change, soil moisture change, and crop seasonal growth status is realized in the ditch or pump well irrigation area.An intelligent measuring terminal for water‐saving irrigation based on rn2026 microcontroller is developed.The terminal uses the coefficient of “water conversion by electricity” to automatically convert the water consumption of farmers and uses the price mechanism of water rights to affect farmers’ water conservation.In combination with changes in groundwater level, crop evapotranspiration, and dynamic changes in soil moisture, precision irrigation strategies are automatically generated to guide farmers to use water rationally.Through the function and performance experiments, the results show that the error of the coefficient of “water conversion by electricity” is less than 1%, the error of electric energy measurement is less than 0.5%, the estimated value of average water use right per unit arable area is consistent with the actual value, and the predicted value of daily average soil moisture change is consistent with the measured value.The equipment has strong adaptability to the environment, high measurement accuracy, strong data processing ability, low cost, and other characteristics.It meets the requirements of water‐saving irrigation technology in practical applications and has good promotion and application value.

Journal: Journal of Sensors (2023)
Publication types: Research Article;