syedzayyan/paper_mill_benchmark huggingface dataset:
Weekly Supervised Administration of Oral Antipsychotics: An Alternative to Long-Acting Injections?

Maintenance of response in schizophrenia is largely dependent on compliance with antipsychotic treatment.When people with schizophrenia are responsible for their own treatment, partial or non-adherence is common and usually results in relapse.Assured compliance with antipsychotic treatment is possible when long-acting injectable antipsychotics are given by healthcare staff, but some patients may not consent to treatment for a variety of reasons.An alternative to long-acting injections is the use of supervised oral administration of long-acting antipsychotics.This method assures compliance with prescribed regimens without the need for injections.To be suitable for once-weekly administration as an oral formulation, an antipsychotic needs to have a sufficiently long duration of action and to be well tolerated in high doses.There is evidence that weekly oral administration of either pimozide or penfluridol is effective and well tolerated in the treatment of schizophrenia.Other drugs potentially suitable for once-weekly oral administration include aripiprazole, brexpiprazole and cariprazine.

Journal: CNS drugs (2022)
Publication types: Journal Article
Work-From-Home During COVID-19 Lockdown: When Employees' Well-Being and Creativity Depend on Their Psychological Profiles.

With the covid-19 pandemic, governments implemented successive lockdowns that forced employees to work from home (wfh) to contain the spread of the coronavirus.This crisis raises the question of the effects of mandatory work from home on employees' well-being and performance, and whether these effects are the same for all employees.In the present study, we examined whether working at home may be related to intensity, familiarity with wfh, employees' well-being (loneliness at work, stress, job satisfaction, and work engagement) and creativity ('subjective' and 'objective').We also examined whether the psychological profile of employees, combining preference for solitude and associated personality variables from the big five, may influence the effects of wfh.The data were collectedviaan online survey from november 13th to december 15th 2020 among 946 employees from various organizations during the second lockdown in france.In addition to identifying two distinctive psychological profiles for employees having to wfh, results revealed that those with a "solitary" profile reported higher loneliness at work, higher levels of stress, and lower levels of job satisfaction and work engagement than those with an "affiliative" profile.It was also found that employees with a "solitary" profile perceived themselves as less creative and produced objectively fewer ideas than individuals with an "affiliative" profile.The present study suggests the necessity to distinguish the profiles of teleworkers and to offer a stronger support for the less affiliative employees when working from home.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article
Low Intensity Focused Ultrasound Increases Duration of Anti-Nociceptive Responses in Female Common Peroneal Nerve Injury Rats.

Chronic pain affects 7%-10% of americans, occurs more frequently and severely in females, and available treatments have been shown to have less efficacy in female patients.Preclinical models addressing sex-specific treatment differences in the treatment of chronic pain have been limited.Here we examine the sex-specific effects of low intensity focused ultrasound (li fus) in a modified sciatic nerve injury (sni) model.Materials and methods a modified sni performed by ligating the common peroneal nerve (cpn) was used to measure sensory, behavioral pain responses, and nerve conduction studies in female and male rats, following li fus of the l5 dorsal root ganglion.Results using the same dose of li fus in females and males of the same weight, cpn latency immediately after treatment was increased for 50 min in females compared to 25 min in males (p < 0.001).Improvements in mechanical pain thresholds after li fus lasted significantly longer in females (seven days; p < 0.05) compared to males (three days; p < 0.05).In females, there was a significant improvement in depression-like behavior as a result of li fus (n = 5; p < 0.01); however, because males never developed depression-like behavior there was no change after li fus treatment.Conclusions neuromodulation with li fus has a greater effect in female rats on cpn latency, mechanical allodynia duration, and depression-like behavior.In order to customize neuromodulatory techniques for different patient phenotypes, it is essential to understand how they may alter sex-specific pathophysiologies.

Journal: Neuromodulation : journal of the International Neuromodulation Society (2022)
Publication types: Journal Article
Plastic Surgery Practice during COVID Times.

Introduction covid-19 has affected plastic surgeons like never before.We conducted an all-india survey to find how the practice was affected among public/private sector, reconstructive/aesthetic practice, and consultants/residents.We have proposed some solutions to the identified problems, which are supported by previous literature.methods a survey framed in google forms was circulated through whats app and emails in august 2020.Closed and semiopen questions regarding changes in personal and professional lives, coping strategies adopted, and open questions for suggestions in improving practice, academics and measures to tackle the pandemic were included.Responses were collected in an excel sheet and analysis done using spss software.results a total of 220 consented responses were obtained.Public hospital practitioners had to bear the covid-related administrative as well as executive works, especially residents, which led to anxiety, family concern, burnout, and concern about the loss of skills and academics.Patient interaction was also reduced.Aesthetic surgeons bore more financial loss.conclusions plastic surgeons in india faced decrease in caseload, financial loss, covid-related duties, workload for residents, reduced academics, family and mental health problems, difficulty with personal protection equipment (ppe) during surgeries, and queries from patients.These can be solved by doing cases within the limits of protocols and safety, pooling public and private sector for covid duties, rotating residents' groups to reduce workload, using telemedicine for academics and patient consultations, and providing social support groups to surgeons.

Journal: Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India (2022)
Publication types: Journal Article
A Cardiac Arrest Case due to Left Coronary Artery Compression in Congenital Heart Disease-Associated Pulmonary Arterial Hypertension.

We report the case of an adult who had a cardiac arrest in the setting of pulmonary hypertension and a previously repaired intermediate atrioventricular septal defect, with left main coronary trunk stenosis due to dilatation of the main pulmonary artery.In patients with pulmonary hypertension exhibiting anginal symptoms, it is advisable to perform chest contrast computed tomography to confirm the pulmonary artery diameter and the presence of coronary artery compression.In addition, our case highlights the importance of early collaboration among specialists during the transition from adolescence to adulthood.

Journal: CJC pediatric and congenital heart disease (2022)
Publication types: Case Reports;Journal Article
Integrating single cell sequencing with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response.

Response to cancer immunotherapies depends on the complex and dynamic interactions between t cell recognition and killing of cancer cells that are counteracted through immunosuppressive pathways in the tumor microenvironment.Therefore, while measurements such as tumor mutational burden provide biomarkers to select patients for immunotherapy, they neither universally predict patient response nor implicate the mechanisms that underlie immunotherapy resistance.Recent advances in single-cell rna sequencing technology measure cellular heterogeneity within cells of an individual tumor but have yet to realize the promise of predictive oncology.In addition to data, mechanistic multiscale computational models are developed to predict treatment response.Incorporating single-cell data from tumors to parameterize these computational models provides deeper insights into prediction of clinical outcome in individual patients.Here, we integrate whole-exome sequencing and sc rna-seq data from triple-negative breast cancer patients to model neoantigen burden in tumor cells as input to a spatial quantitative system pharmacology model.The model comprises a four-compartmental quantitative system pharmacology sub-model to represent a whole patient and a spatial agent-based sub-model to represent tumor volumes at the cellular scale.We use the high-throughput single-cell data to model the role of antigen burden and heterogeneity relative to the tumor microenvironment composition on predicted immunotherapy response.We demonstrate how this integrated modeling and single-cell analysis framework can be used to relate neoantigen heterogeneity to immunotherapy treatment outcomes.Our results demonstrate feasibility of merging single-cell data to initialize cell states in multiscale computational models such as the sp qsp for personalized prediction of clinical outcomes to immunotherapy.

Journal: Immunoinformatics (Amsterdam, Netherlands) (2021)
Publication types: Journal Article
A metallic anti-biofouling surface with a hierarchical topography containing nanostructures on curved micro-riblets.

Metallic surface finishes have been used in the anti-biofouling, but it is very difficult to produce surfaces with hierarchically ordered structures.In the present study, anti-biofouling metallic surfaces with nanostructures superimposed on curved micro-riblets were produced via top-down fabrication.According to the attachment theory, these surfaces feature few attachment points for organisms, the nanostructures prevent the attachment of bacteria and algal zoospores, while the micro-riblets prohibit the settlement of macrofoulers.Anodic oxidation was performed to induce superhydrophilicity.It forms a hydration layer on the surface, which physically blocks foulant adsorption along with the anti-biofouling topography.We characterized the surfaces via scanning electron and atomic force microscopy, contact-angle measurement, and wear-resistance testing.The contact angle of the hierarchical structures was less than 1°.Laboratory settlement assays verified that bacterial attachment was dramatically reduced by the nanostructures and/or the hydration layer, attributable to superhydrophilicity.The micro-riblets prohibited the settlement of macrofoulers.Over 77 days of static immersion in the sea during summer, the metallic surface showed significantly less biofouling compared to a surface painted with an anticorrosive coating.

Journal: Microsystems & nanoengineering (2022)
Publication types: Journal Article
Personalized neoantigen vaccine combined with PD-1 blockade increases CD8+tissue-resident memory T-cell infiltration in preclinical hepatocellular carcinoma models.

Personalized neoantigen vaccine could induce a robust antitumor immune response in multiple cancers, whose efficacy could be further enhanced by combining with programmed cell death 1 blockade (α-pd-1).However, the corresponding immune response and synergistic mechanisms remain largely unclear.Here, we aimed to develop clinically available combinational therapeutic strategy and further explore its potential antitumor mechanisms in hepatocellular carcinoma (hcc).Methods neoantigen peptide vaccine (neo vac) for murine hcc cell line hepa1-6 was developed and optimized by neoantigen screening and adjuvant optimization.Then the synergistic efficacy and related molecular mechanisms of neo vac combined with α-pd-1 in hcc were evaluated by orthotopic hcc mouse model, single-cell rna sequencing, tetramer flow cytometry, immunofluorescence, etc.The tumor-killing capacity of cd8+tissue-resident memory t cells (cd8+trms) was assessed by orthotopic hcc mouse model, and autologous patient-derived cells.Results neo vac, which consisted of seven high immunogenic neoantigen peptides and clinical-grade poly(i:c), could generate a strong antitumor immune response in hcc mouse models.Significantly, its efficacy could be further improved by combining with α-pd-1, with 80% of durable tumor regression and long-term immune memory in orthotopic hcc models.Moreover, in-depth analysis of the tumor immune microenvironment showed that the percentage of cd8+trmswas remarkedly increased in neo vac plus α-pd-1 treatment group, and positively associated with the antitumor efficacy.In vitro and in vivo t-cell cytotoxicity assay further confirmed the strong tumor-killing capacity of cd8+trmssorting from orthotopic mouse hcc or patient's hcc tissue.Conclusions this study showed that neo vac plus α-pd-1 could induce a strong antitumor response and long-term tumor-specific immune memory in hcc by increasing cd8+trmsinfiltration, which might serve as a potential immune-therapeutic target for hcc.

Journal: Journal for immunotherapy of cancer (2022)
Publication types: Journal Article
Reference and Ghost Proteins Identification in Rat C6 Glioma Extracellular Vesicles.

Extracellular vesicles (evs) mediate intercellular communication and regulate a broad range of biological processes.Novel therapeutic strategies have emerged based on the use of evs as biological nanoparticles.To separate isolated evs from protein aggregates and the external part of evs membrane proteins, we performed a trypsin/lys c digestion treatment of evs pellets, followed by amicon filtration.After these steps, all the fractions have been subjected to proteomic analyses.Comparison between 6 h trypsin/lys c treatment or non-treated evs revealed a quantitative variation of the surface proteins.Some surface proteins have been demasked after 6 h enzymatic digestion like cd81, cd82, ust, vcan, lamp 1, rab43, annexin a2, synthenin, and vsp37b.Moreover, six ghost proteins have also been identified and one corresponds to a long noncoding rna.We thus demonstrate the presence of ghost proteins in evs produced by glioma cells that can contribute to tumorigenesis.

Journal: iScience (2020)
Publication types: Journal Article
Optical tissue clearing in combination with perfusion and immunofluorescence for placental vascular imaging.

Imaging of placental tissues is a difficult task, because of specific for this organ complex multicellular and 3d tissue structure.The tissue clearing systems (x-clarity) system is a valuable tool for the examining the expression of molecular pathways in whole tissues and organs, originally developed for brain imaging.in the present report, we utilized this technology for the examination of placental vasculature and protein expression in perfused human placental tissue.the placental tissue was sufficiently cleared with preservation of endothelial staining and fluorescent markers, allowing visualization using confocal microscopy.The clarity method and x-clarity system is a valuable tool in placental imaging.

Journal: Medicine (2018)
Publication types: Journal Article
Effects of an 80% cigarette price increase on quit attempts, successful quitting and smoking intensity among Korean adult smokers: results from nationally representative longitudinal panel data.

S south korea implemented an unprecedented cigarette tax increase in 2015, raising its cigarette price by 80%.This study evaluated the extent to which the 2015 cigarette tax increase affected korean adult smokers in terms of quit attempts, successful quitting and smoking intensity.Methods data were drawn from a nationally representative longitudinal study, the korean welfare panel study (waves 9-12, 2014-2017).Korean adults who smoked before the 2015 cigarette tax increase comprised the sample (n=2114).We used the multiple logistic regressions to examine factors of quit attempts and successful quitting and the generalised estimating equations to estimate changes in smoking intensity among continued smokers.Results after the cigarette tax increase, 60.9% (n=1334) of baseline smokers attempted to quit and 34.7% of the attempters succeeded in quitting.The smokers aged ≥ 65 years and light smokers both attempted more (p<0.01) and succeeded more (p<0.05) in quitting than smokers aged 35-44 years and heavy smokers, respectively.The successful quitting was not significantly associated with income levels.Depressive symptoms, first cigarette use before age 19 and smoking a pack or more a day at baseline were associated with failures in quitting.Smoking intensity among continued smokers decreased after the cigarette tax increase (p<0.001), but such a decrease was not observed in light smokers, young smokers and high-income smokers.Conclusion the current study findings imply that the korean government may consider implementing periodic increases in cigarette tax which should reflect the rate of inflation and income growth.Smoking cessation programmes need to address depressive symptoms.

Journal: Tobacco control (2021)
Publication types: Journal Article
T-cell Lymphoblastic Lymphoma in a Patient With Chromosome 8q21.11 Microdeletion.

The chromosome 8q21.11 deletion syndrome is an extremely rare genetic condition characterized by facial dysmorphic features, peters anomaly and impaired intellectual development.We report a case of a 2-year-old female with chromosome 8q21.11-q21.2 microdeletion complicated by t-cell lymphoblastic lymphoma.Whole genome single-nucleotide polymorphism microarray detected an interstitial deletion of 8q21.11 to q.21.2, including 16 genes.Autopsy findings revealed a t-cell lymphoblastic lymphoma presenting as an anterior mediastinal mass, encroaching upon the aortic arch, left subclavian artery, left carotid bifurcation and trachea.The genes that may contribute to a neoplastic process are identified (pkia, il7, tpd52, pag1, and fabp5) and discussed in this article.

Journal: Journal of pediatric hematology/oncology (2022)
Publication types: Case Reports;Journal Article
Psychometric Properties of the Freiburg Life Quality Assessment for Wounds Among Burned Patients.

And purpose psychometric performance of quality of life (qo l) instruments must be evaluated prior to use.The freiburg life quality assessment for wounds (flqa-w) emerged as one possible tool for burned patients.The purpose of this study was to assess the performance of flqa-w in this population.Methods composite reliability (cr) coefficients were estimated; convergent validity was assessed by burns specific health scale-revised (bshs-r), abbreviated qo l instrument (whoqol-bref), and the visual analog scale; and responsiveness by comparing with the three visual analog scales.Results cr coefficients of flqa-w domains were suitable (0.72-0.88).Correlations were strong and negative (r = -.51 to -.76).Responsiveness was adequate-statistically significant changes were observed.Conclusions the results indicate reliable, valid, and responsive psychometric performance of the flqa-w among burned patients.

Journal: Journal of nursing measurement (2018)
Publication types: Journal Article;Validation Study
Advances in Electrochemical Ammonia Synthesis Beyond the Use of Nitrogen Gas as a Source.

Electrocatalytic reduction of dinitrogen has emerged as a new strategy for ammonia synthesis.Despite being environmentally benign and energy-saving, it suffers from low conversion efficiency and short yield of ammonia because of the challenges of activating the inert n≡n bond at room temperature and atmospheric pressure.As a result of this, researchers proposed to reduce the nitrogenous species, one category of air and water pollutants, into valuable ammonia.Although remaining largely underexplored, this alternative approach shows promising efficiency for ammonia synthesis, while achieving high catalytic activity and selectivity remains challenging.In this minireview, we summarize recent electrocatalytic performances of denitrification with selective formation to ammonia in terms of proposed active sites and reaction mechanisms.Additionally, we discuss the common issues in the state-of-the-art experimental tests and highlight the breakthroughs via computational screening of electrode materials.The aim of this is to steer the future research directions in the field, which is aiming for an optimal catalytic system with higher activity and selectivity for electrocatalytic denitrification.

Journal: ChemPlusChem (2021)
Publication types: Journal Article;Review
A new deep-sea palaemonid shrimp assigned to Periclimenes Costa, 1844 (Decapoda: Caridea) from the West Mariana Ridge, northwestern Pacific.

A new palaemonid species, periclimenes variabilis, is described and illustrated on the basis of four specimens from the ritto seamount, west marina ridge, northwestern pacific, at depths of 642-666 m.Specimens of the new species were collected with an unidentified hexacoral of primnoidae (cnidaria), an antipatharian octocoral leiopathes sp.(cnidaria), and an unidentified crinoid (echinodermata), suggesting association with those invertebrates.Morphological comparison and molecular phylogenetic analyses using the mitochondrial 16s ribosomal rna and cytochrome c oxidase subunit i genes indicate that the new species is closest to periclimenes uniunguiculatus bruce, 1990 although the possession of more than two spiniform setae on either side of the telson in the new species is consistent with the generic diagnosis of bathymenes kou, li & bruce, 2016.In reference to the close relationship to the species currently assigned to periclimenes costa, 1844 and the unsettled taxonomy of the genus, the new species is provisionally assigned to periclimenes.Differentiating characters between the new species and closely related taxa are discussed.

Journal: Zootaxa (2023)
Publication types: Journal Article
The Role of the European Society of Human Genetics in Delivering Genomic Education.

The european society of human genetics (eshg) was founded in 1967 as a professional organisation for members working in genetics in clinical practice, research and education.The society seeks the integration of scientific research and its implementation into clinical practice and the education of specialists and the public in all areas of medical and human genetics.The society works to do this through many approaches, including educational sessions at the annual conference; training courses in general and specialist areas of genetics; an online resource of educational materials (euro gems); and a mentorship scheme.The eshg education committee is implementing new approaches to expand the reach of its educational activities and portfolio.With changes in technology, appreciation of the utility of genomics in healthcare and the public's and patients' increased awareness of the role of genomics, this review will summarise how the eshg is adapting to deliver innovative educational activity.

Journal: Frontiers in genetics (2021)
Publication types: Journal Article