syedzayyan/paper_mill_benchmark huggingface dataset:
Clinical Characteristics of 606 Patients with Community-Acquired Pyogenic Liver Abscess: A Six-Year Research in Yantai.

This study was designed to analyze the clinical characteristics, etiological characteristics, drug resistance, and empirical use of antibiotics for community-acquired pyogenic liver abscess (pla) to provide a basis for rational and effective empirical treatment of pla in the local area.Methods the clinical data, etiological characteristics, drug resistance, and empirical anti-infective therapy schemes of 606 patients with pla were collected and analyzed retrospectively.Results the included patients were mainly males, with a male-to-female ratio of 1.3:1.The average age of the patients was 60.3 ± 14.1 years.The underlying diseases were diabetes and biliary tract disease, accounting for 38.7% and 22.3%, respectively.The main clinical manifestations were fever (92.9%), abdominal pain (44.7%), and nausea (33.3%).Imaging findings: the proportion of patients with a single lesion was 74.7%, and 67% of the patients had involvement in the right lobe of the liver.The main pathogen was klebsiella pneumoniaeaccounted for 74.9% in blood culture and 84.1% in pus culture, mainly extended-spectrum β-lactamase.In 272 strains negative for extended-spectrum β-lactamase (esbls), 100% were resistant to ampicillin and less than 50% were sensitive to nitrofurantoin.Only 36 esbl-positive strains had higher than 80% sensitivity to carbapenems, β-lactamase inhibitor compound, and amikacin.Patients treated with different treatment methods showed significantly different average length of hospital stay (14 [9-21] vs 13 [8-18]).Empirical anti-infective therapy: beta-lactamase complex, carbapenems, cephalosporins, and quinolones were used in 280 (37.6%), 180 (29.7%), 180 (29.7%), and 147 (24.3%) patients, respectively.Conclusion patients with community-acquired pla in this area are mainly males, and the underlying diseases are mainly diabetes and hepatobiliary system disease.The main clinical manifestation is fever, so patients with fever of unknown cause should pay attention to possible liver abscesses.Based on drug sensitivity tests, the empirical use of antibiotics is somewhat unreasonable.

Journal: Infection and drug resistance (2022)
Publication types: Journal Article
The Surveillance of Physical Activity, Sedentary Behavior, and Sleep: Protocol for the Development and Feasibility Evaluation of a Novel Measurement System.

There is increasing recognition of the need for more comprehensive surveillance data, including information on physical activity of all intensities, sedentary behavior, and sleep.However, meeting this need poses significant challenges for current surveillance systems, which are mainly reliant on self-report.Objective the primary objective of this project is to develop and evaluate the feasibility of a sensor-based system for use in the surveillance of physical activity, sedentary behavior, and sleep (sur pass) at a national level in denmark.Methods the sur pass project involves an international, multidisciplinary team of researchers collaborating with an industrial partner.The sur pass system consists of (1) a thigh-worn accelerometer with bluetooth connectivity, (2) a smartphone app, (3) an integrated back end, facilitating the automated upload, analysis, storage, and provision of individualized feedback in a manner compliant with european union regulations on data privacy, and (4) an administrator web interface (web application) to monitor progress.The system development and evaluation will be performed in 3 phases.These phases will include gathering user input and specifications (phase 1), the iterative development, evaluation, and refinement of the system (phase 2), and the feasibility evaluation (phase 3).Results the project started in september 2020 and completed phase 2 in february 2022.Phase 3 began in march 2022 and results will be made available in 2023.Conclusions if feasible, the sur pass system could be a catalyst toward large-scale, sensor-based surveillance of physical activity, sedentary behavior, and sleep.It could also be adapted for cohort and interventional research, thus contributing to the generation of evidence for both interventions and public health policies and recommendations.International registered report identifier (irrid) derr1-.

Journal: JMIR research protocols (2022)
Publication types: Journal Article
Optimizing scalable, technology-supported behavioral interventions to prevent opioid misuse among adolescents and young adults in the emergency department: A randomized controlled trial protocol.

Preventing opioid misuse and opioid use disorder is critical among at-risk adolescents and young adults (ayas).An emergency department (ed) visit provides an opportunity for delivering interventions during a rapidly changing opioid landscape.This paper describes pilot data and the protocol for a 2 × 2 factorial randomized controlled trial testing efficacy of early interventions to reduce escalation of opioid (prescription or illicit) misuse among at-risk ayas.Interventions are delivered using technology by health coaches.Ayas ages 16-30 in the ed screening positive for prescription opioid use (+ ≥ 1 risk factor) or opioid misuse will be stratified by risk severity, sex, and age group.Participants will be randomly assigned to a condition at intake, either a live video health coach-delivered single session or a control condition of an enhanced usual care (euc) community resource brochure.They are also randomly assigned to one of two post-intake conditions: health coach-delivered portal-like messaging via web portal over 30 days or euc delivered at 30 days post-intake.Thus, the trial has four groups: health coach-delivered session+portal, health coach-delivered session+euc, euc + portal, and euc + euc.Outcomes will be measured at 3-, 6-, and 12-months.The primary outcome is opioid misuse based on a modified alcohol smoking and substance involvement screening test.Secondary outcomes include other opioid outcomes (e.g., days of opioid misuse, overdose risk behaviors), other substance misuse and consequences, and impaired driving.This study is innovative by testing the efficacy of feasible and scalable technology-enabled interventions to reduce and prevent opioid misuse and opioid use disorder.Trial registration:clinical trials.gov university of michigan hum00177625 nct registration: nct04550715.

Journal: Contemporary clinical trials (2021)
Publication types: Clinical Trial Protocol;Journal Article;Research Support, U.S. Gov't, P.H.S.
Transmission event of SARS-CoV-2 Delta variant reveals multiple vaccine breakthrough infections.

Importance vaccine breakthrough by an emergent sars-co v-2 variant poses a great risk to global public health.Objective to determine the sars-co v-2 variant responsible for 6 cases of vaccine breakthrough.Design nasopharyngeal swabs from suspected vaccine breakthrough cases were tested for sars-co v-2 by q pcr for wuhan-hu1 and alpha variant.Positive samples were then sequenced by swift normalase amplicon panels to determine the causal variant.Setting transmission event occurred at events surrounding a wedding outside of houston, tx.Two patients from india, likely transmitted the delta variant to other guests.Participants following a positive sars-co v-2 q pcr test at a third-party site, six fully vaccinated patients were investigated.Three males and three females ranged from 53 to 69 years old.One patient suffered from diabetes while three others were classified as overweight.No significant other comorbidities were identified.None of the patients had a history of failed vaccination.

Journal: medRxiv : the preprint server for health sciences (2021)
Publication types: Preprint;Journal Article
Mobile, Remote, and Individual Focused: Comparing Breath Carbon Monoxide Readings and Abstinence Between Smartphone-Enabled and Stand-Alone Monitors.

Introduction newly available, smartphone-enabled carbon monoxide (co) monitors are lower in cost than traditional stand-alone monitors and represent a marked advancement for smoking research.New products are promising, but data are needed to compare breath co readings between smartphone-enabled and stand-alone monitors.The purpose of this study was to (1) determine the agreement between the mobile i co (bedfont scientific ltd) with two other monitors from the same manufacturer (micro+ pro and micro+ basic) and (2) determine optimal, monitor-specific, cotinine-confirmed abstinence cutoff values.Methods adult (≥18) smokers (n = 26) and nonsmokers (n = 21) provided three breath co samples (using three different monitors) in each of 10 sessions, and urine cotinine was measured for gold standard determination of abstinence.Co comparisons (n = 437) were analyzed using regression-based bland-altman analysis of agreement; receiver operating characteristics curves were used to determine optimal abstinence cutoffs.Results bland-altman analyses indicated that the i co monitor provided higher co results than both micro+ monitors.Sensitivity and specificity analyses showed that the optimal co cutoff for determining abstinence was <3 ppm for the micro+ pro (88% sensitivity, 93% specificity) and micro+ basic (83% sensitivity, 98% specificity), but was higher for the i co (<6 ppm; 73% sensitivity, 100% specificity).Conclusions relative to both micro+ monitors, the smartphone-enabled i co provided systematically higher co values and required a higher cutoff to reliably determine smoking abstinence.This does not indicate that co values obtained using the i co are not valid; instead, these results suggest that monitor-specific abstinence cutoffs are needed to ensure accurate bioverification of smoking status.Implications results from this study indicate that co values from the smartphone-enabled i co should not be used interchangeably with the stand-alone micro+ pro and micro+ basic, particularly when lower co values (<10 ppm) are critical (ie, determination of abstinence vs confirming smoking status for study inclusion).Optimal co cutoffs recommended for determining abstinence on micro+ and i co monitors are at <3 and <6 ppm, respectively.

Journal: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
The relationship between interdependent and independent self-construals and social anxiety symptom severity in a clinical sample of treatment-seeking patients.

Differences in cultural orientations, such as interdependent and independent self-construals, may influence social anxiety disorder (sad) symptom presentations.However, prior research on the association between interdependent/independent self-construals and sad was limited to non-clinical samples.Using a treatment-seeking population with clinical levels of anxiety, the current study extends prior research by examining whether the relationship between interdependent/independent self-construals and sad is specific to sad or indicative of a broader relationship with anxiety or depression more generally.We also expand upon prior work by examining the effect of self-construals on treatment outcomes and whether self-construals change over time.The results showed that endorsing a less independent self-construal was associated with greater sad symptoms specifically, and was not associated with other anxiety or depression symptom measures.Additionally, while interdependent and independent self-construals did not moderate sad treatment outcomes, there was a decrease in interdependent self-construal and increase in independent self-construal over a course of cognitive behavioral therapy.Notably, this change over time was tied to specific items that correlated strongly with sad symptoms.Together, these results increase our understanding of the relationship between interdependent/independent self-construals and sad symptoms in treatment-seeking anxiety patients.

Journal: Transcultural psychiatry (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Research Support, N.I.H., Extramural
The Fundus Structural and Functional Predictions of DME Patients After Anti-VEGF Treatments.

Diabetic retinopathy (dr) is an important complication with a high incidence of 34.6% in the diabetic populations.Dr could finally lead to vision impairment without effective interventions, during which, diabetic macular edema (dme) is a key phase causing visual loss.Up to date, antivascular endothelial growth factor (anti-vegf) therapy is the first-line treatment for dme which has achieved relatively better clinical outcomes than traditional treatments.However, there are several kinds of anti-vegf medicines, and patients are sensitive to different anti-vegf treatments.In addition, its effectiveness is unstable.Considering the patients' need to accept continual anti-vegf treatments and its price is comparatively high, it is clinically important to predict the prognosis after different anti-vegf treatments.In our research, we used the demographic and clinical data of 254 dme patients and 2,763 optical coherence tomography (oct) images from three countries to predict the fundus structural and functional parameters and treatment plan in 6 months after different anti-vegf treatments.Eight baseline features combined with 11 models were applied to conduct seven prediction tasks.Accuracy (acc), the area under curve (auc), mean absolute error (mae), and mean square error (mse) were respectively used to evaluate the classification and regression tasks.The acc and auc of structural predictions of retinal pigment epithelial detachment were close to 1.000.The mae and mse of visual acuity predictions were nearly 0.3 to 0.4 log mar.The acc of treatment plan regarding continuous injection was approaching 70%.Our research has achieved great performance in the predictions of fundus structural and functional parameters as well as treatment plan, which can help ophthalmologists improve the treatment compliance of dme patients.

Journal: Frontiers in endocrinology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Nutritional Intake Influences Zinc Levels in Preterm Newborns: An Observational Study.

(1) background: zinc is a key element for protein synthesis in preterm newborns.Early aggressive nutrition, promoting protein synthesis, may increase zinc consumption; (2) methods: we performed a prospective observational study, to assess the relationship between early macronutrients intake and serum zinc levels, in preterm newborns with gestational age (ga) of 24-35 weeks, consecutively observed in neonatal intensive care unit (nicu).(3) results: we enrolled 130 newborns (ga 31.5 ± 2.8).A significant negative correlation between serum zinc level at 28 days of life and energy (r -0.587,p< 0.001) and protein intake (r -0.556,p< 0.001) in the first week of life was observed.Linear regression analysis showed that zinc levels depended on energy (β -0.650;p< 0.001) and protein (β -0.669;p< 0.001) intake given through parenteral nutrition (pn) in the first week of life; (4) conclusions: zinc status of preterm neonates was influenced by early protein and energy intake.An additional zinc supplementation should be considered when high protein and energy intake are received by preterm newborns in the first week of life.

Journal: Nutrients (2020)
Publication types: Journal Article;Observational Study
Applying archaeology to fire investigation techniques: A review.

Archaeology and fire investigation do not appear to have much in common on the surface.Scratch beneath however, and the similarities begin to reveal themselves.Both disciplines require the investigation of physical remains by employing an analytical approach in order to reconstruct sequences of events.Before recovery employing an archaeological stratigraphic recording method at fire scenes, provides the opportunity for a sequential recording of both debris layers, recording objects and their relationship to the immediate environment.This approach is particularly pertinent in fire investigation, as the recovery of evidence can lead to destruction in cases of fragile evidence and remains.

Journal: Forensic science international (2022)
Publication types: Journal Article;Review
Derivation of human induced pluripotent stem cell (iPSC) line from a 79year old sporadic male Parkinson's disease patient.

Peripheral blood was collected from a clinically diagnosed 79-year old male sporadic parkinson's disease patient.Peripheral blood mononuclear cells (pbmcs) were reprogrammed with the yamanaka kmos reprogramming factors using the sendai-virus reprogramming system.The transgene-free i psc line showed pluripotency verified by immunofluorescent staining for pluripotency markers, and the i psc line was able to differentiate into the 3 germ layers in vivo.The i psc line also showed normal karyotype.This in vitro cellular model can be used to study the mechanism of sporadic parkinson's disease and to test new drugs.Resource table.

Journal: Stem cell research (2017)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The provenance of the raw material and the manufacturing technology of copper artefacts from the Copper Age hoard from Magyaregres, Hungary.

In 2016, a stollhof-type copper hoard was found during an excavation in magyaregres, hungary.It was placed in a cooking pot, and deposited upside down within the boundaries of an early copper age settlement.Similar hoards dating to the end of the 5th millennium bce are well-known from central europe, however, this hoard represents the only one so far with thoroughly documented finding circumstances.The hoard contained 681 pieces of copper, 264 pieces of stone and a single spondylus bead, along with 19 pieces of small tubular spiral copper coils, three spiral copper bracelets, and two large, spectacle spiral copper pendants.Until now, information on the provenance of raw materials and how such copper artefacts were manufactured has not been available.The artefacts were studied under optical microscopes to reveal the manufacturing process.Trace elemental composition (hr-icp-ms) and lead isotope ratios (mc-icp-ms) were measured to explore the provenance of raw materials.The ornaments were rolled or folded and coiled from thin sheets of copper using fahlore copper probably originating from the northwestern carpathians.A complex archaeological approach was employed to reveal the provenance, distribution and the social roles the ornaments could have played in the life of a copper age community.Evidence for local metallurgy was lacking in contemporaneous transdanubian sites, therefore it is likely that the items of the hoard were manufactured closer to the raw material source, prior to being transported to transdanubia as finished products.The method of deposition implies that such items were associated with special social contexts, represented exceptional values, and the context of deposition was also highly prescribed.The magyaregres hoard serves as the first firm piece of evidence for the existence of a typologically independent central european metallurgical circle which exploited the raw material sources located within its distribution.

Journal: PloS one (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
An immune infiltration-related long non-coding RNAs signature predicts prognosis for hepatocellular carcinoma.

With a high incidence and dismal survival rate, hepatocellular carcinoma (hcc) tops the list of the world's most frequent malignant tumors.Immunotherapy is a new approach to cancer treatment, and its effect on prolonging overall survival (os) varies from patient to patient.For a more effective prognosis and treatment of hcc, we are committed to identifying immune infiltration-related long non-coding rnas (iirls) with prognostic value in hepatocellular carcinoma.methods:in our study, we calculated immune scores of 369 hepatocellular carcinoma samples from the cancer genome atlas (tcga) database by using an estimation algorithm, and obtained long non-coding rnas (lnc rnas) associated with immune infiltration by using weighted gene co-expression network analysis (wgcna).For training cohort, univariate cox, least absolute shrinkage and selection operator (lasso) and multivariate cox regression analysis were used to determine prognostic iirls, we established a prognostic iirls signature.By testing cohort and entire cohort, we confirmed that the signature is practical.The prognosis of people with different clinicopathological stages and risk scores were predicted by the nomogram we constructed.In addition, immune cell infiltration analysis and prediction of therapeutic drugs were performed.results:93 iirls were obtained by wgcna.Furthermore, the prognostic value of these iirls were evaluated by using univariate cox, lasso and multivariate cox analysis.Four iirls were used to create a signature with a prognosis.Time-related receiver operating characteristic (roc) curve revealed that this model had an acceptable prognostic value for hcc patients.By using univariate and multivariate cox regression analysis, this risk score has been shown to be an independent prognostic factor for hcc.The nomogram we made showed good predictions.Except for that, the treatment with immune checkpoint inhibitors (ici) was likely to be more effective for low-risk patients.conclusion:based on four iirls, a prognostic signature was created in this research showed good accuracy in predicting os.This study also provided valuable references for immunotherapy of hepatocellular carcinoma.

Journal: Frontiers in genetics (2022)
Publication types: Journal Article
Atopic and Contact Dermatitis of the Vulva.

Pruritus, or itch, is a common vulvar complaint that is often treated empirically as a yeast infection; however, yeast infections are just one of the many conditions that can cause vulvar itch.Ignoring other conditions can prolong pruritus unnecessarily.Atopic dermatitis, irritant contact dermatitis, and allergic contact dermatitis are extremely common noninfectious causes of vulvar itch that are often underdiagnosed by nondermatologists.Identifying these conditions and treating them appropriately can significantly improve a patient's quality of life and appropriately decrease health care expenditures by preventing unnecessary additional referrals or follow-up visits and decreasing pharmaceutical costs.

Journal: Obstetrics and gynecology clinics of North America (2017)
Publication types: Journal Article;Review