syedzayyan/paper_mill_benchmark huggingface dataset:
Surgical Indication and Approach are Associated with Transfusion in Hysterectomy for Benign Disease.

To identify pre-operative and intraoperative factors associated with the risk of red blood cell transfusion among women undergoing hysterectomy.Methods a retrospective cohort study of hysterectomy for benign indications between january 1, 2011 - december 31, 2017.Patients receiving blood transfusion within 30 days of surgery were compared to patients who did not receive any transfusion.Multivariate logistic regression analysis was performed to identify clinical and surgical variables associated with blood transfusion.Results among 171,940 women who underwent hysterectomy for benign indication, 4,667 (2.7%) required blood transfusion.The rate of transfusion was highest among patients with uterine fibroids (4.3%) and lowest in patients with genital prolapse (1.1%) (p < 0.05).Odds of blood transfusion were significantly elevated in patients undergoing hysterectomy for uterine fibroids compared to patients with genital prolapse (adjusted odds ratio [a or] 1.36, 95% confidence interval [ci] 1.15 - 1.61).Other patient characteristics included body mass index, smoking, bleeding disorders, pre-operative sepsis, and american society of anesthesiologists score ≥ 2 (p < 0.05).Higher pre-operative hematocrit significantly decreased the risk of blood transfusion (a or 0.84, 95% ci 0.84 - 0.85 per percent increase in hematocrit).Abdominal and vaginal hysterectomies were associated with greater odds of transfusion compared with laparoscopic approaches (a or 5.06, 95% ci 4.70 - 5.44; a or 1.87, 95% ci 1.67 - 2.10, respectively).Conclusions certain patient comorbidities, surgical indication, and approach to hysterectomy are associated with increased risk of blood transfusion.These results may have implications for pre-operative patient counseling, perioperative care, and health system planning.

Journal: JSLS : Journal of the Society of Laparoendoscopic Surgeons (2022)
Publication types: Journal Article
Poorer surgical outcomes at 2 years postoperatively in patients with lumbar spinal stenosis with long-term preoperative leg numbness: a single-center retrospective study.

The purpose of this study was to assess whether differences in duration of preoperative leg numbness lead to different surgical outcomes.Methods this study included patients with lumbar spinal stenosis (lss) who underwent lumbar fusion surgery in our hospital from january 2018 to september 2020.Patients were divided into three groups based on duration of preoperative leg numbness: no numbness (nn) group, short-term numbness (stn) group (leg numbness ≤ 3 months) and long-term numbness (ltn) group (leg numbness > 3 months).The numerical rating scale of leg pain (nrs-lp) and leg numbness (nrs-ln), oswestry disability index (odi) and short-form health survey (sf-36) were collected before surgery and at 3, 6, 12 and 24 months postoperatively.Results 178 patients were included in this study.At 24 months postoperatively, nrs-lp was significantly higher in ltn than in nn [nn vs.Stn vs.Ltn: 0 (0,1) vs.0 (0,1) vs.1 (0,1)] (p = 0.033).Nrs-ln in stn [2 (1,3)] was significantly lower than in ltn [3 (2,3)] (p < 0.001).Sf-36 was significantly lower in ltn than in other two groups (nn vs.Stn vs.Ltn: 86.10 ± 6.02 vs.84.09 ± 5.59 vs.78.93 ± 6.57) (p < 0.001).Odi was significantly higher in ltn than in other two groups [nn vs.Stn vs.Ltn: 18 (15,22) vs.18 (16,20) vs.21 (19,24)] (p = 0.001).Conclusions patients with lss with long-term preoperative leg numbness have poorer outcomes at 2 years postoperatively.Surgical intervention should be performed before persistent leg numbness for more than 3 months to obtain a better prognosis.

Journal: Journal of orthopaedic surgery and research (2022)
Publication types: Journal Article
Pollution Characteristics, Sources, and Health Risk Assessments of Potentially Toxic Elements in Community Garden Soil of Lin'an, Zhejiang, China.

The characteristics, sources and risk assessment of heavy metal pollution in community garden soil of lin'an district were evaluated.The 28 soil samples from community garden were collected for determination of 7 heavy metal elements.The geostatistical analysis, spearman correlation coefficient, principal component analysis and pmf model have explored sources of heavy metal pollution.The health risk assessment model has assessed ecological risk of heavy metals.The results revealed that average concentration of as, cd, cr, cu, ni, pb and zn were 16.0, 0.158, 76.1, 34.6, 45.8, 20.9 and 166 mg kg-1, respectively.Whereas as, cd, cr, cu, ni and zn were higher than background values.The spatial distribution of heavy metal pollution in the southwest of the study area was higher than northeast.The pollution sources of cd, cu, ni and zn in the study area were due to agricultural activities (42.9%), cr and pb were from traffic sources (36.2%), and as was domestic pollution (20.9%) according to spearman correlation coefficient, principal component analysis and pmf model.The non-carcinogenic risks of as (5.39), cr (3.53) and ni (2.07) have a value of 1, which indicated significant risk.The potentially toxic elements have not exceeded maximum threshold of usepa, with regard to carcinogenic risk, while as (3.37e-05) and cr (5.74e-05) have exceeded the safety range.It is concluded that soils of community gardens are facing pollution problem due to potentially toxic elements which require environmental monitoring of the soil to reduce risk of human health.

Journal: Bulletin of environmental contamination and toxicology (2022)
Publication types: Journal Article
A double reaction system induced electrochemiluminescence enhancement based on SnS2QDs@MIL-101 for ultrasensitive detection of CA242.

At present, the development of electrochemiluminescence (ecl) immunosensor with excellent performance is still the research focus of immunoassay and detection.Herein, sn s2quantum dots (sn s2qds) and metal-organic framework (mil-101 (cr)) are effectively combined to achieve synergistic signal amplification based on k2s2o8co-reactant, thereby constructing sn s2qds/so4•-and so4•-/o2ecl double reaction luminous systems.Sn s2qds and singlet oxygen (1(o2)2*) produced from the system as light-emitting devices jointly enhance the ecl response and significantly improve the sensitivity of the ecl immunosensor.Dissolved oxygen and sn s2qds respectively generate hoo•and sn s2qds•-under negative potential, and react with transient so4•-to emit strong light respectively, so as to jointly enhance the ecl response.Mil-101 catalyzes the oxygen cathode reduction reaction to promote the conversion of dissolved oxygen into hoo•, which greatly improves the ecl response of1(o2)2*.Cu s with spherical nanoflower-like form as a co-reaction promoter of k2s2o8generate more so4•-active substances, which further enhance the ecl response of the immunosensor.The constructed ecl immunosensor has the advantages of low detection limit, high sensitivity and better stability.Under the optimal conditions, the detection range is 0.1 m u/m l∼100 u/m l, and the detection limit is 0.015 m u/m l.The results show that the constructed ecl immunosensor can detect human ca242 samples and have a broad application prospect in biological analysis and early diagnosis of diseases.

Journal: Talanta (2022)
Publication types: Journal Article
Daylong Mobile Audio Recordings Reveal Multitimescale Dynamics in Infants' Vocal Productions and Auditory Experiences.

The sounds of human infancy-baby babbling, adult talking, lullaby singing, and more-fluctuate over time.Infant-friendly wearable audio recorders can now capture very large quantities of these sounds throughout infants' everyday lives at home.Here, we review recent discoveries about how infants' soundscapes are organized over the course of a day based on analyses designed to detect patterns at multiple timescales.Analyses of infants' day-long audio have revealed that everyday vocalizations are clustered hierarchically in time, vocal explorations are consistent with foraging dynamics, and musical tunes are distributed such that some are much more available than others.This approach focusing on the multi-scale distributions of sounds heard and produced by infants provides new, fundamental insights on human communication development from a complex systems perspective.

Journal: Current directions in psychological science (2022)
Publication types: Journal Article
Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation.

Methylation at cytosines (m cg) is a well-known regulator of gene expression, but its requirements for cellular differentiation have yet to be fully elucidated.A well-studied cellular differentiation model system is the eye lens, consisting of a single anterior layer of epithelial cells that migrate laterally and differentiate into a core of fiber cells.Here, we explore the genome-wide relationships between m cg methylation, chromatin accessibility and gene expression during differentiation of eye lens epithelial cells into fiber cells.Results whole genome bisulfite sequencing identified 7621 genomic loci exhibiting significant differences in m cg levels between lens epithelial and fiber cells.Changes in m cg levels were inversely correlated with the differentiation state-specific expression of 1285 genes preferentially expressed in either lens fiber or lens epithelial cells (pearson correlation r = - 0.37, p < 1 × 10-42).M cg levels were inversely correlated with chromatin accessibility determined by assay for transposase-accessible sequencing (atac-seq) (pearson correlation r = - 0.86, p < 1 × 10-300).Many of the genes exhibiting altered regions of dna methylation, chromatin accessibility and gene expression levels in fiber cells relative to epithelial cells are associated with lens fiber cell structure, homeostasis and transparency.These include lens crystallins (cryba4, crybb1, crygn, crybb2), lens beaded filament proteins (bfsp1, bfsp2), transcription factors (hsf4, sox2, hif1a), and notch signaling pathway members (notch1, notch2, hey1, hes5).Analysis of regions exhibiting cell-type specific alterations in dna methylation revealed an overrepresentation of consensus sequences of multiple transcription factors known to play key roles in lens cell differentiation including hif1a, sox2, and the maf family of transcription factors.Conclusions collectively, these results link dna methylation with control of chromatin accessibility and gene expression changes required for eye lens differentiation.The results also point to a role for dna methylation in the regulation of transcription factors previously identified to be important for lens cell differentiation.

Journal: Epigenetics & chromatin (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Sex Differences in Cardiovascular Disease Mortality in Brazil between 1996 and 2019.

Cardiovascular diseases (cvd) are brazil's leading causes of death in women and men.This study analyzed age-adjusted death rate (draj) trends from all causes of death (acd), cvd, ischemic heart disease (ihd), and stroke in women and men aged 35 to 74 years from 1996 to 2019.Methods we analyzed draj trends for all causes of death (acd), cvd, ihd, and stroke.Data were from the ministry of health mortality database.Joinpoint regression programtm performed trend analysis and adjustments in death rates.Average annual percentage change (aapc) determined the intensity of changes.Results in women, draj reduced for acd (aapc = -1.6%); cvd (aapc = -2.6%); ihd (aapc = -1.9%); and stroke (aapc = -4.6%) (p< 0.001 for all).In men, acd reduced from 1996 to 2004 (aapc = -0.9%;p< 0.001), from 2012 to 2019 (aapc = -1.9%;p< 0.001), and unchanged from 2004 to 2012; cvd (aapc = -2.1%); ihd (aapc = -1.5%); stroke (aapc = -4.9%) (p< 0.001 for all) reduced from 1996 to 2019.From 1996 to 2019, the male/female ratio for acd remained unchanged.Cvd increased from 1.58 to 1.83, ihd from 1.99 to 2.30, and stroke from 1.52 to 1.83.Conclusion acd, cvd, ihd, and stroke were reduced more significantly in women, and the ratio of cvd, ihd, and cvd in men and women increased more in men.Future studies will be needed to determine the main factors responsible for a better outcome in women.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article
Spike-Timing-Dependent Plasticity Mediated by Dopamine and its Role in Parkinson's Disease Pathophysiology.

Parkinson's disease (pd) is a multi-systemic neurodegenerative brain disorder.Motor symptoms of pd are linked to the significant dopamine (da) loss in substantia nigra pars compacta (snc) followed by basal ganglia (bg) circuit dysfunction.Increasing experimental and computational evidence indicates that (synaptic) plasticity plays a key role in the emergence of pd-related pathological changes following da loss.Spike-timing-dependent plasticity (stdp) mediated by da provides a mechanistic model for synaptic plasticity to modify synaptic connections within the bg according to the neuronal activity.To shed light on how da-mediated stdp can shape neuronal activity and synaptic connectivity in the pd condition, we reviewed experimental and computational findings addressing the modulatory effect of da on stdp as well as other plasticity mechanisms and discussed their potential role in pd pathophysiology and related network dynamics and connectivity.In particular, reshaping of stdp profiles together with other plasticity-mediated processes following da loss may abnormally modify synaptic connections in competing pathways of the bg.The cascade of plasticity-induced maladaptive or compensatory changes can impair the excitation-inhibition balance towards the bg output nuclei, leading to the emergence of pathological activity-connectivity patterns in pd.Pre-clinical, clinical as well as computational studies reviewed here provide an understanding of the impact of synaptic plasticity and other plasticity mechanisms on pd pathophysiology, especially pd-related network activity and connectivity, after da loss.This review may provide further insights into the abnormal structure-function relationship within the bg contributing to the emergence of pathological states in pd.Specifically, this review is intended to provide detailed information for the development of computational network models for pd, serving as testbeds for the development and optimization of invasive and non-invasive brain stimulation techniques.Computationally derived hypotheses may accelerate the development of therapeutic stimulation techniques and potentially reduce the number of related animal experiments.

Journal: Frontiers in network physiology (2022)
Publication types: Journal Article;Review
Two Case Reports of Upper Extremity Venous Thrombosis From Midline Catheter Placement in Pregnancy.

Midline catheters are often inserted in pregnant women for whom a prolonged hospital stay is anticipated to facilitate the administration of medications and for blood sampling.Midline catheters compared with peripheral intravenous catheters are associated with fewer venipunctures and scheduled line changes.We present 2 cases of pregnant women with no personal or family history of thrombosis who underwent midline catheter insertion and developed venous thromboembolism of the upper extremity requiring anticoagulation therapy.Studies are needed to evaluate the safety profile of midline catheters in pregnancy.

Journal: A&A practice (2020)
Publication types: Case Reports;Journal Article
Empirical Study on Classifiers for Earlier Prediction of COVID-19 Infection Cure and Death Rate in the Indian States.

Machine learning methods can play a key role in predicting the spread of respiratory infection with the help of predictive analytics.Machine learning techniques help mine data to better estimate and predict the covid-19 infection status.A fine-tuned ensemble classification approach for predicting the death and cure rates of patients from infection using machine learning techniques has been proposed for different states of india.The proposed classification model is applied to the recent covid-19 dataset for india, and a performance evaluation of various state-of-the-art classifiers to the proposed model is performed.The classifiers forecasted the patients' infection status in different regions to better plan resources and response care systems.The appropriate classification of the output class based on the extracted input features is essential to achieve accurate results of classifiers.The experimental outcome exhibits that the proposed hybrid model reached a maximum f1-score of 94% compared to ensembles and other classifiers like support vector machine, decision trees, and gaussian naïve bayes on a dataset of 5004 instances through 10-fold cross-validation for predicting the right class.The feasibility of automated prediction for covid-19 infection cure and death rates in the indian states was demonstrated.

Journal: Healthcare (Basel, Switzerland) (2022)
Publication types: Journal Article
Effects of acute ischemic stroke on binaural perception.

Stroke-induced lesions at different locations in the brain can affect various aspects of binaural hearing, including spatial perception.Previous studies found impairments in binaural hearing, especially in patients with temporal lobe tumors or lesions, but also resulting from lesions all along the auditory pathway from brainstem nuclei up to the auditory cortex.Currently, structural magnetic resonance imaging (mri) is used in the clinical treatment routine of stroke patients.In combination with structural imaging, an analysis of binaural hearing enables a better understanding of hearing-related signaling pathways and of clinical disorders of binaural processing after a stroke.However, little data are currently available on binaural hearing in stroke patients, particularly for the acute phase of stroke.Here, we sought to address this gap in an exploratory study of patients in the acute phase of ischemic stroke.We conducted psychoacoustic measurements using two tasks of binaural hearing: binaural tone-in-noise detection, and lateralization of stimuli with interaural time- or level differences.The location of the stroke lesion was established by previously acquired mri data.An additional general assessment included three-frequency audiometry, cognitive assessments, and depression screening.Fifty-five patients participated in the experiments, on average 5 days after their stroke onset.Patients whose lesions were in different locations were tested, including lesions in brainstem areas, basal ganglia, thalamus, temporal lobe, and other cortical and subcortical areas.Lateralization impairments were found in most patients with lesions within the auditory pathway.Lesioned areas at brainstem levels led to distortions of lateralization in both hemifields, thalamus lesions were correlated with a shift of the whole auditory space, whereas some cortical lesions predominantly affected the lateralization of stimuli contralateral to the lesion and resulted in more variable responses.Lateralization performance was also found to be affected by lesions of the right, but not the left, basal ganglia, as well as by lesions in non-auditory cortical areas.In general, altered lateralization was common in the stroke group.In contrast, deficits in tone-in-noise detection were relatively scarce in our sample of lesion patients, although a significant number of patients with multiple lesion sites were not able to complete the task.

Journal: Frontiers in neuroscience (2022)
Publication types: Journal Article
Data Resource Profile of Shizuoka Kokuho Database (SKDB) Using Integrated Health- and Care-insurance Claims and Health Checkups: The Shizuoka Study.

Analyzing real-world data, including health insurance claims, may help provide insights into preventing and treating various diseases.We developed a database covering shizuoka prefecture (shizuoka kokuho database [skdb]) in japan, which included individual-level linked data on health- and care-insurance claims and health checkup results.Methods anonymized claims data on health insurance (national health insurance [age <75 years] and latter-stage elderly medical care system [age ≥75 years]), care insurance, subscriber lists, annual health checkups, and all dates of death were collected from 35 municipalities in shizuoka prefecture.To efficiently link claims and health checkups, unique individual ids were assigned using a novel procedure.Results from april 2012 to september 2018, the skdb included 2,230,848 individuals (men, 1,019,687; 45.7%).The median age (min-max) of men and women was 60 (0-106) and 62 (0-111) years, respectively.During the study period, the median subscription time was 4.4 years; 40.8% of individuals continuously subscribed for the 6.5 years; 213,566 individuals died.Health checkup data were available for 654,035 individuals, amounting to 2,469,648 records.Care-service recipient data were available for 283,537 individuals; they used care insurance to pay for care costs.Conclusion skdb, a population-based longitudinal cohort, provides a comprehensive dataset covering health checkups, disorders, medication, and care service.This database may provide a robust platform to identify epidemiological problems and generate hypotheses for preventing and treating disorders in the elderly.

Journal: Journal of epidemiology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Predicting Dynamic Properties of Asphalt Mastic Considering Asphalt-Filler Interaction Based on 2S2P1D Model.

The relationship between the various phases of asphalt materials, from asphalt binder to mastic and mixture, has received great attention over the years, with efforts being made to establish linkages among these phases.Many methods for predicting the rheology properties of asphalt mastics from those of asphalt and filler volume fractions exist.However, most prediction methods are based on an empirical formula and on the micromechanical model.Very few research studies focus on the constitutive model.In addition, relatively little research has explored the influence of asphalt-filler interaction on mastic's rheology properties, which is believed to be an important factor.In this study, the 2s2p1d (two springs, two parabolic elements, and one dashpot) model was applied to link the behavior of asphalt binder, filler volume fraction, asphalt-filler interaction and asphalt mastic.First, the interaction between asphalt and filler was evaluated, and the interaction parameter c of the palierne model was used as an assessment indicator to calculate the effective filler volume fraction of asphalt mastic.Then, the relation between the 2s2p1d model parameters of asphalt mastic and those of asphalt binder and the effective filler volume fraction was analyzed.Finally, a simple relationship associating the 2s2p1d model parameters h, log(τ0) of mastic and that of asphalt binder and the effective filler volume fraction was developed.The proposed expression was validated, and the result showed that it was an efficient model for the shear complex modulus prediction of virgin asphalt mastic.

Journal: Materials (Basel, Switzerland) (2022)
Publication types: Journal Article