syedzayyan/paper_mill_benchmark huggingface dataset:
Meta-Analysis on the Anesthetic Effects of Remifentanil plus Dexmedetomidine versus Remifentanil Alone in Cardiac Surgery

In this study, we performed a meta-analysis to investigate the anesthesia effects of remifentanil plus dexmedetomidine versus remifentanil alone in cardiac surgery.Literature search was performed on pub med, web of science, embase, china knowledge infrastructure, wanfang data, and other databases for relevant literature published in english or chinese before october 2021.A total of 17 studies, consisting of 1350 patients, were included in this study.Of these, 10 studies showed that remifentanil plus dexmedetomidine had a good anesthesia effect in cardiac surgery ( or = 3.61 , 95% ci: 1.73, 7.52, p &lt; 0.001 ), and 8 studies showed that the ramsay score test of anesthesia ( smd = 0.88 ; 95% ci: -0.77, 2.53; p &lt; 0.001 ) in the experimental group was better than that in the control group.In addition, changes in the hemodynamic heart rate ( smd = − 0.74 ; 95% ci: -1.41, -0.07; p &lt; 0.001 ) and mean arterial pressure ( smd = − 0.18 ; 95% ci: -0.72, 0.36; p &lt; 0.001 ) of the two groups of anesthesia were counted in 17 studies, which also showed that the anesthesia effect of remifentanil plus dexmedetomidine was good.Thus, remifentanil plus dexmedetomidine may be a more promising option for cardiac surgery anesthesia than remifentanil alone.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Meta-Analysis;
Meta-Analysis of the Application Effect of Different Modalities of Thermal Ablation and Surgical Treatment in Papillary Thyroid Microcarcinoma

Papillary thyroid microcarcinoma (ptmc) refers to papillary thyroid carcinoma (ptc) with a maximum diameter of 10 mm.Thermal ablation, including radiofrequency ablation (rfa), microwave ablation (mwa), and laser ablation (la), has been applied in the treatment of benign thyroid nodules and captured extensive attention.At present, the application of thermal ablation in ptmc has been extensively reported, but outcomes such as volume reduction rate (vrr), complete remission rate (crr), and adverse reaction rate (arr) vary considerably.Therefore, this meta-analysis was performed to evaluate the safety and efficacy of different treatment methods of ptmc.Methods.We did a systematic review and network meta-analysis.We searched pub med, embase, and cochrane-library from the date of inception to january 10, 2022, to retrieve the vrr, crr, and arr of mwa, rfa, la and surgical treatment of ptmc, and a meta-analysis was performed using the r meta-package.Odds ratios (ors) and 95% confidence intervals (cis) were calculated, and sensitivity analyses, cumulative meta-analyses, and publication bias were also performed.Relevant literature was retrieved with keywords; the eligible cohort studies were screened based on the established inclusion and exclusion criteria.Results.A total of 1515 patients were included in the 12-month follow-up.The overall vrr was 86.25% (95% ci: 77.89, 94.60), and the vrr was rfa &gt; wma &gt; la, but the differences were not significant.A total of 1483 patients were included in the last follow-up.The overall vrr was 99.41% (95% ci: 99.11, 99.72), and the vrr was rfa &gt; wma &gt; la, but the differences were not significant.A total of 1622 patients showed complete remission at the last follow-up, and the overall crr was 0.63 (95% ci: 0.46, 0.79).The crr was rfa &gt; la &gt; wma, but the differences were not significant.A total of 1883 patients had adverse reactions at the last follow-up, and the overall arr was 0.06 (95% ci: 0.03, 0.08).The arr at the last follow-up was rfa = surg &lt; la &lt; wma .The arr of the rfa and surg subgroups was significantly lower than that of the wma subgroup.Conclusions.Similar good efficacy and safety profiles were observed in wma, rfa, la, and surgical treatment in ptmc, among which rfa showed the best volume reduction, complete remission rate, and adverse reaction reduction.However, there is a slight bias in the limited literature included in this study, and we did not conduct or refer to mechanistic studies to confirm its specific mechanism of action.Clinicians are advised to use their discretion in the choice of treatment.

Journal: Disease Markers (2022)
Publication types: Meta-Analysis;
Meta-Analysis of Tai Chi Chuan in Treating Lumbar Spondylosis and Back Pain

The effectiveness of tai chi chuan in treating various ailments has been well reported; however, its effect on back pain and lumbar spondylosis remains unclear.Methods.We performed this meta-analysis under the guidelines of the preferred reporting items for systematic reviews and meta-analyses (prisma), and the research-associated search was performed over the provided databases: embase, cochrane library, web of science, pub med, scopus, and cinahl in the period of 2008 to 2016, to recognize the related studies.We used the physiotherapy evidence database (pedro) scale to measure the standard of the involved randomized control trials (rcts).The accumulated outcomes with parameters of weighted mean difference (wmd) and confidence level (ci) of 95% were evaluated to discover the influence of tai chi over pain as well as dysfunction among the patients suffering from pain depending on the outcome model.Results.Seven eligible studies with a total of 296 participants were identified that met inclusion criteria for the systematic review; in the forest plot analysis, it was noted that for 95% ci, the standardized mean difference found to be -1.58 (-1.79, -1.38) with the heterogeneity of 87%, thereby favoring tai chi over the control group; a comparison was drawn for tai chi with routine therapy against the routine therapy alone, where 95% ci for -1.22 [-1.47, -0.97] is observed for i 2 = 0 % for the overall effect z = 9.42 ( p &lt; 0.00001 ); pain intensity of tai chi was compared with the control group, where 95% ci for -1.62 [-2.09, -1.14] was observed for z = 6.69 ( p &lt; 0.00001 ).The forest plot subgroup analysis of tai chi was compared with the control group for an unchanged lifestyle, where 95% ci for -2.26 [-2.61, -1.91] was observed for z = 12.76 ( p &lt; 0.00001 ).Conclusion.Our results indicate that tai chi individually or with additional treatment along with routine physical exercises might reduce the pain and functional disorders for the patients suffering from back pain.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Meta-Analysis;
Meta-Analysis of Prognostic Correlation of Thrombectomy for Cerebral Infarction Based on Intelligent Medical Treatment

A meta‐analysis is used to investigate the correlation between the status of collateral circulation assessed by head ct angiography (cta) and the outcome of thrombectomy for cerebral infarction.Meta‐analysis is conducted.The experimental results show that the national institutes of health stroke scale (nihss) score, modified rankin scale (m rs) score, incidence of cerebral hemorrhage, and mortality in the group with good collateral circulation are significantly lower than those in the group with bad collateral circulation, and the rate of good prognosis is significantly higher ( p &lt; 0.05).The evaluation and treatment of patients with cerebral infarction and their prognosis based on cta intelligent medical technology are related to collateral circulation, and the effect of effectively reducing the risk of death, cerebral hemorrhage, and neurological function injury and improving the prognosis is more obvious in each collateral circulation.

Journal: BioMed Research International (2022)
Publication types: Meta-Analysis;
Meta-Analysis of Predictive Role of Early Neurological Deterioration after Intravenous Thrombolysis

With the popularization of intravenous thrombolysis, more and more people use intravenous thrombolysis to treat related diseases, but problems also arise.There are still a considerable number of patients with early disease after thrombolytic therapy not only not significantly improving, but also progressing, that is, early neurological deterioration (end).In view of this problem, the prediction of end after intravenous thrombolysis becomes very important.With the development of medical technology, research on the prediction of end after intravenous thrombolysis has gradually been carried out.Effective prediction is of great significance for the prevention and treatment of end after intravenous thrombolysis.This article aimed to carry out a meta-analysis of the predictive role of end after intravenous thrombolysis.Through an informed analysis of all studies of this type in this field, this article determines a method for predicting end after intravenous thrombolysis.The actual effect of its role is revealed in this paper, and its purpose is to promote the development of this field.This article addresses the same type of study on the predictive role of neurological deterioration after intravenous thrombolysis.The article performs test and meta-analysis of its role by conditionally searching for literature studies.It is explained using the relevant theoretical formulas.The analysis results show that the prediction of end after intravenous thrombolysis in this paper can effectively help make a preliminary judgment on the possible later neurological deterioration.Although there is an error between the predicted curve and the actual curve, the difference between the two is between 1% and 5%.It can basically effectively predict the occurrence of end.Therefore, the prediction of end after intravenous thrombolysis has a very large preventive effect on the end after intravenous thrombolysis.

Journal: Emergency Medicine International (2022)
Publication types: Meta-Analysis;
Melatonin Attenuates Cisplatin-Induced Ototoxicity via Regulating the Cell Apoptosis of the Inner Ear

The mechanism of ototoxicity caused by cisplatin is currently unclear, and the induced apoptosis may play an important role in inner ear injury.Melatonin has high antioxidant and antiapoptotic effects.This study is aimed at clarifying the protective effect on the inner ear and the underlying mechanism of melatonin.Design.The mice and hei-oc1 cells were randomly separated into four groups: control group, cisplatin group, melatonin group, and cisplatin exposure after melatonin pretreatment group.Place and duration of the study.From september 2018 to september 2021, all experiments were completed at the second hospital of shandong university.And the study was approved by the ethics committee of the second hospital of shandong university (kyll-2020 (kj) a-0191).Methodology.Mice were pretreated with peritoneal injection of melatonin prior to the application of cisplatin.Auditory brainstem response (abr) test was performed before and after treatment, then the temporal bones were collected for histology investigation.Hei-oc1 cells were pretreated with melatonin before adding cisplatin.The apoptosis of hei-oc1 cells was observed by mts, tunel, and flow cytometry, respectively.Moreover, the m rna expression of apoptosis-related factors was detected by q rt-pcr.Results.Abr and morphological analysis showed that cisplatin caused damage to the function and structure of the inner ear.Mts, tunel, and flow cytometry showed that the application of cisplatin caused a significant increase in the apoptosis level of hei-oc1 cells, and melatonin pretreatment reduced this damage.Moreover, melatonin pretreatment reversed the m rna expression changes of apoptosis-related factors induced by cisplatin.Conclusions.Apoptosis is involved in the inner ear dysfunction caused by cisplatin.Melatonin reduces the ototoxicity of cisplatin by regulating the induced apoptosis response.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Medicinal Applications of Banana Peel Flour Used as a Substitute for Computing Dietary Fiber for Wheat Flour in the Biscuit Industry

The aim of this study, medicinal applications of banana peel flour, was used to estimate nutrition value and minerals content.The results indicated that banana peel flour was safe for food application, and it was lower in protein and fat and higher in dietary fiber and total carbohydrate which were 52.68 and 67.25%, respectively.Moreover, the minerals content of phosphorous, potassium, sodium, manganese, and calcium were 217.92, 110.24, 96.43, 85.25, and 80.27 mg/100 g, respectively.Furthermore, the problem of the study investigated the effect of banana peel flour incorporation with wheat flour with 72% extraction to produce biscuit blends at different ratios of 5.0, 10.0, 15.0, and 20.0%, respectively.The nutrition value and mineral content of banana peel flour in biscuits increased gradually in the blends, according to the results.The methods of study of the four biscuit blends were prepared with banana peel flour substituted and wheat flour extraction of 72 percent, and they were compared to a control biscuit.Sensory properties reported that the control biscuit was the highest score followed by blends which had contained 5, 10, and 15% banana peel flour.Meanwhile, the blend of biscuit fortified with 20% was not accepted by panelists.From the color biscuits, the blends containing 5, 10, and 15% banana peel flour had acceptable color, and the blends' color was not acceptable.This may be caused by dark color and high dietary fiber.The texture profile analyzer and physical characteristics were confirmed and gave the same results.The result is that it could be recommended that the banana peel flour, which has high fiber content, produce acceptable biscuits fortified with 5, 10, and 15% and become functional foods.Panelists did not find the 20% blend biscuits to be particularly appealing.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Medical Data Analysis of CYP1B1 Gene Polymorphism and Clinical Prognosis of Minimally Invasive Surgery for Lung Cancer

To address the issue of genetic mutations in medical records, clinical studies on minimally invasive surgery for breast cancer have been proposed.The cyp1b1 gene is mainly a single‐nucleotide mutation, which affects the enzymatic reaction related to carcinogens and causes the susceptibility differences of different individuals.First, the survival rate and other factors influencing the estimation of 120 leukemia patients were examined with the help of various medical records by establishing an organization for auxiliary diagnosis of lung cancer based on expertise.Secondly, through the treatment of 120 leukemia patients after minor surgery, the average life expectancy of 120 patients was 19 months, the one‐year survival rate was 74.61%, and the two‐year survival rate was 32.70%.Currently, there are more than 160 cases of cyp1b1 discovered.In recent years, people have gradually entered into in‐depth research on the correlation between genes and lung cancer, which is of great significance to the treatment and research of lung cancer.An analysis showed patients’ age, stage, whether they would work, whether radiation therapy and antibiotics were offered, and so on.S has a direct impact on patient survival, and many tests have shown that the patient’s age, stage, whether it will work, and whether fire radiation and drug therapy are provided are important interventions for patients with anemia.Finally, in patients with leukemia, especially during the restricted period, combined treatment with a physician, radiologist, and surgeon should be initiated as soon as possible.For a wide range of disease, depending on the use of chemotherapy, local metastasis with antibiotics can improve the disease.After success, it is more beneficial to choose second‐line treatment.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Mechanism of Dexmedetomidine Intervention on Neurogenic Inflammation in Cognitive Impairment Rats after Partial Hepatectomy

To study the effect of dexmedetomidine on cognitive function in rats with cognitive impairment after partial hepatectomy and its mechanism.Methods.60 sd rats were randomly divided into 4 groups ( n = 15 ): blank control group (cg group), sham operation group (sham group), cognitive impairment model group (pocd group), and dexmedetomidine + cognitive impairment model group (dex group).Rats in the pocd group underwent left lobe hepatectomy and intraperitoneal injection of the same amount of normal saline after resuscitation.Rats in the dex group underwent left lobe hepatectomy and intraperitoneal injection of dexmedetomidine 50 μg/kg.Group cg was not operated on and the same amount of normal saline was injected intraperitoneally.In the sham group, liver resection was not allowed after the abdominal incision, and normal saline was injected intraperitoneally.Rats were injected every 24 hours for 5 consecutive days.Morris water maze (mwm) were used to evaluate the effects of dexmedetomidine on learning and memory ability of pocd rats.Tunel method was used to detect apoptotic neurons in the hippocampus.Inos, arg-1, il-6, and tnf-αexpression levels were detected.Western blot detects the expression level of tnf-α, bcl-2, and nf-κb protein.Result.Compared with the cg group, the escape latency of the other three groups was prolonged on the 5th day after the operation, and the number of crossing the platform was reduced.Compared with the sham group, the escape latency of the pocd group and dex group was significantly prolonged, and the number of crossing the platform was significantly reduced on day 5 ( p &lt; 0.05 ).Compared with the pocd group, the dex group shortened the escape latency and increased the number of crossing the platform on the 5th day ( p &lt; 0.05 ).It shows that the spatial learning and memory function of rats has been restored to a certain extent.the number of i nos and arg-1 positive cells in the pocd group and dex group was higher than that in the control group, and the number of arg-1 positive cells in the dex group was higher than that in the pocd group ( p &lt; 0.05 ).Western blot results the expression of bcl-2 and nf-κb protein in pocd group, and dex group was higher than that of the sham group ( p &lt; 0.05 ).The expression of bcl-2 and nf-κb protein was the most in pocd group.The expression of bcl-2 and nf-κb protein in dex group was lower than that in pocd group ( p &lt; 0.05 ).Conclusion.Behavioral results showed that the learning and cognitive ability of pocd model rats after hepatectomy was impaired, and inflammatory factors and activated microglia were found in the hippocampus of pocd rats.Dexmedetomidine may improve the brain function of pocd rats by inhibiting neuronal apoptosis,partly through nf-κb apoptosis pathway.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Mechanism of Anti-Inflammatory Drugs in the Early Treatment of Oral Gingival Mucosa and Soft Tissue Trauma

Traumatic tissue develops an uncontrolled inflammatory response that causes secondary damage to the injured tissue and other parts of the body.Therefore, preventing wound infection, reducing inflammatory response, and reducing secondary tissue damage are the keys to early treatment of tissue trauma.In the treatment of gingival soft tissue trauma, anti‐inflammatory and analgesic drugs are reasonably selected according to the condition, which can effectively reduce inflammation, and they help periodontal tissue regeneration and healing.However, there are few studies on the mechanism of anti‐inflammatory drugs in the early treatment of oral gingival mucosal soft tissue trauma, and the specific mechanism is unknown.Therefore, this paper explored the mechanism of anti‐inflammatory drugs in the early treatment of oral gingival mucosa and soft tissue trauma through experiments, which provided theoretical support for the clinical treatment of gingival mucosa and soft tissue trauma repair.In this paper, two anti‐inflammatory drugs, levofloxacin and metronidazole, were selected to measure their release properties in vitro and in vivo .Then, the white‐eared rabbits were treated with gingival wound treatment experiments, and the physiological characteristics, intratissue pressure, tissue partial pressure of oxygen, il‐6 content, and pge2 content were determined at each postinjury period, and the mechanism of action of anti‐inflammatory drugs was determined.Research results have shown that anti‐inflammatory drugs can significantly inhibit the content of il‐6 and pge2 in gingival soft tissue after injury, reduce the local inflammatory response, and accelerate tissue healing.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Machine Learning for Ischemic Heart Disease Diagnosis Aided by Evolutionary Computing

Heart disease is the leading cause of death from chronic diseases in the developing countries.The difficulty of making an accurate and timely diagnosis is exacerbated by a lack of resources and professionals in some areas, which contributes to this reality.Medical professionals may benefit from technological advancements that aid in the accurate diagnosis of patients.In light of these findings, a hybrid diagnostic tool has been developed that combines several computational intelligence (machine learning) techniques capable of analyzing clinical histories and images of electrocardiogram signals and indicating whether or not the patient has ischemic heart disease with up to 97.01% accuracy.Working with medical experts and a database containing clinical data on approximately 1020 patients and their diagnoses was required for this project.Both were put to use.A picture database containing 92 images of electrocardiogram signals was also used in this project for the analysis of the artificial neural network.After extensive research and testing by the medical community, which supported the project and provided positive feedback, a successful tool was developed.This demonstrated the tool’s effectiveness.

Journal: Applied Bionics and Biomechanics (2021)
Publication types: Research Article;
Low-Dose X-Ray Increases Paracellular Permeability of Human Renal Glomerular Endothelial Cells

Glomerular endothelium functions as a filtration barrier of metabolites in the kidney.Although x-ray irradiation modulated the permeability of the vascular endothelium, the response of human renal glomerular endothelial cells (hrgecs) to low-dose x-ray irradiation has not been investigated.We evaluated the impacts of low-dose x-ray irradiation on hrgecs and revealed the underlying mechanism.Methods.Hrgecs were exposed to x-ray with doses of 0, 0.1, 0.5, 1.0, and 2.0 gy.The proliferation, viability, and apoptosis of hrgecs were examined by mtt assay, trypan blue staining assay, and tunel staining, respectively.The paracellular permeability was assessed by paracellular permeability assay.The expression of ve-cadherin was investigated via immunofluorescence assay.Western blot and q rt-pcr detected the expression levels of ve-cadherin and cldn5.Besides, the expression levels of p ve-cadherin (p y658), tgf-β, tgf-βri, src, p-src, smad2, p-smad2, smad3, p-smad3, snail, slug, and apoptosis-related proteins were tested by western blot.Results.The proliferation, viability, and apoptosis of hrgecs were not affected by low-dose (&lt;2.0 gy) x-ray irradiation.X-ray irradiation dose-dependently reduced the level of ve-cadherin, and ve-cadherin and cldn5 levels were reduced with x-ray irradiation.The levels of p y658, p-src, p-smad2, and p-smad3 were upregulated with the increase in x-ray dose.Besides, the paracellular permeability of hrgecs was increased by even low-dose (&lt;2.0 gy) x-ray irradiation.Therefore, low-dose x-ray irradiation reduced the cumulative content of ve-cadherin and increased the level of p y658 via activation of the tgf-β signaling pathway.Conclusion.Even though low-dose x-ray exposure had no impact on proliferation, viability, and apoptosis of hrgecs, it increased the paracellular permeability by deterioration and downregulation of ve-cadherin through stimulating the tgf-β signaling pathway.This study built the framework for kidney response to low-dose irradiation exposure.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;