syedzayyan/paper_mill_benchmark huggingface dataset:
Application and Management of Financial Sharing Under the Background of Big Data Era

With the advent of the big data(bd) era, financial information and group financial management have shown new characteristics.Bd technology also provides support for the construction of shared centers.The establishment of financial shared service centers is the future development direction of large and medium-sized enterprises.The purpose of this article is to study the application and management of financial sharing under the background of the bd era.This article is the development trend of financial shared service center under the background of bd.It briefly described the development and evolution of financial shared services, and pointed out the challenges and future development trends of the construction of financial shared service centers under the background of bd.This article discusses the principles, objectives, overall planning, specific design and issues that should be paid attention to in the construction of the group’s financial shared service center under the background of bd.This paper proposes the framework model and process design of group capital management.Taking the framework model of the financial shared service center under cloud accounting as the core, build a group fund management framework model based on financial shared services under cloud accounting, and then further develop process design for fund budget management, fund control management, fund supervision and management, and fund assessment management.At the same time, it analyzes the causes of the group’s existing personnel career planning and high operating costs, proposes solutions, and investigates the development trend of the financial shared service center.Research shows that the audit error rate of the financial shared service center of surveyed companies in 2014 was 1.27% to 0.57% in 2018.It can be seen that the audit error rate basically fluctuates, which further verifies that the financial shared service center has strict requirements for internal management.The internal service level of the financial shared service center is continuously optimized and improved.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
Overexpression of Cosmc suppresses cell migration and invasion in different subtypes of breast cancer cells via Tn and T glycans

Objectives: the high mortality of breast cancer (bc) is associated with the strong metastatic properties of primary breast tumor cells.The present study was conducted in order to clarify the effect of cosmc on the growth and metastasis of bc cell lines of different molecular types, which may be implicated in the regulation of tn and t glycans.Methods: bc cell lines with different molecular types were transduced with sh rna targeting cosmc or, cosmc overexpression plasmid in order to explore the role of cosmc in cell proliferation, migration, invasion, and apoptosis.The protein levels of tn, t, cosmc, proliferation-related factors (ki67 and pcna) and apoptosis-related factors (bax and bad) in bc cell lines were determined by western blot analyses.Finally, the role of cosmc was substantiated through in vivo experiments.Results: cosmc was down-regulated in different subtypes of bc cell lines compared with normal control cells.Overexpression of cosmc suppressed the proliferation, migration, and invasion, yet promoted the apoptosis of bc cells, as reflected by in vitro experiments.Additionally, in vivo tumor xenografts in nude mice showed that ectopic overexpression of cosmc inhibited the tumor growth of bc cells.Consequently, the levels of proliferation-related factors and tn antigen were decreased, while those of apoptosis-related factors and t antigen were increased in bc cells.This observation was confirmed in vivo in xenograft tumors.Conclusion: collectively, up-regulation of cosmc potentially impedes bc growth and metastasis by modulating the balance between tn and t glycans.

Journal: Bioscience Reports (2020)
Publication types: Research Article;
Research on the Impact of Institutional Environment and Corporate Governance on Enterprise Performance and Competitive Advantage Based on Big Data Analysis

In the era of big data, the highly developed information technology and the ever-increasing speed of product upgrading make enterprises face more turbulence.Good institutional environment and effective corporate governance can improve the competitive advantage of enterprises.The source of sustainable competitive advantage of enterprises should include macro-level institutional competition with government as the main body and micro-level corporate governance competition with enterprises as the main body.How to continue the competitive advantage of enterprises through the arrangement of external system and internal system is the core problem faced by chinese enterprises under the background of institutional change.The problem of competitive advantage of enterprises is accompanied by the objective problem of market economic system, which is the logical result of the arrangement of competitive system.The institutional background of china’s accession to wto has changed the competitive environment of enterprises, and made the competitive advantage of chinese enterprises based on the original foundation facing threats.The essence of introducing wto rules is a kind of institutional change.When the specific framework of laws and regulations supporting the system changes, enterprises need to follow this change to carry out institutional transformation at the micro level.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
The Transformation of Financial Supervision Paradigm Under the Background of Financial Technology Based on Computer Technology

While improving financial efficiency and enriching financial products, financial technology has also brought about the generalization of financial risks.The financial rules under the traditional financial supervision paradigm are usually the product of crisis-based legislation and regulation.They are characterized by “command and control” and cannot cope with the pan-financialization brought by financial technology, the frequent financial risks, the endogenous and exogenous financial systems.Risk and other issues.The transformation of the financial regulatory paradigm is imperative.According to the analysis of big data, the new paradigm of financial supervision requires the establishment of cross-industry risk supervision institutions on top of specialized financial supervision institutions to prevent risks from being passed inside and outside the financial system.Requires adaptive supervision to reasonably allocate financial rule-making powers among financial legislatures, financial regulatory agencies, and regulated institutions; requires experimental supervision to deal with time-consuming issues of supervisory intervention; requires real-time or true data-driven supervision.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
Long non-coding RNA GATA6-AS1 upregulates GATA6 to regulate the biological behaviors of lung adenocarcinoma cells

Background lung adenocarcinoma (luad) is known to be one of the leading causes of cancer-related deaths globally.In recent decades, long non-coding rnas (lnc rnas) have been indicated to exert pivotal regulating functions in multiple biological behaviors in the initiation and development of luad.However, the functional mechanism of lnc rna gata binding protein 6 antisense rna 1 (gata6-as1) in luad has not been explored.Methods in the current study, gata6-as1 expression in luad tissues was revealed.Meanwhile, gata6-as1 expression in luad cells was investigated via rt-q pcr analysis.After a549 and h1975 cells were transfected with gata6-as1 overexpression plasmids, ed u and colony formation assays, tunel assays and flow cytometry analyses, as well as wound healing and transwell assays were conducted to detect cell proliferation, apoptosis, migration and invasion.Afterwards, bioinformatic tools, western blot analyses, dual-luciferase reporter assays, and rna immunoprecipitation (rip) assays were performed to investigate the correlation of micro rna-4530 (mi r-4530), gata6-as1 and gata6.Results we found that gata6-as1 expression was low-expressed in luad tissues and cells.Furthermore, the upregulation of gata6-as1 suppressed the proliferative, migration and invasion abilities, as well as promoted apoptotic rate of a549 and h1975 cells.Moreover, the mechanistic investigations revealed that gata6-as1 upregulated the expression of its cognate sense gene gata6 by binding with mi r-4530, thereby modulating the malignant progression of luad cells.Conclusions gata6-as1 repressed luad cell proliferation, migration and invasion, and promoted cell apoptosis via regulation of the mi r-4530/gata6 axis, indicating gata6-as1 as a new prognostic biomarker for luad.

Journal: BMC Pulmonary Medicine (2021)
Publication types: Research Article;
Construction of E-commerce Personalized Information Recommendation System in the Era of Big Data

With the continuous expansion of the scale of e-commerce, personalized recommendation technology has been widely used.However, the traditional recommendation system has been unable to meet the current needs of data processing, and good big data processing ability has become the basic requirement of the new personalized recommendation system.In addition, traditional recommendation systems are often limited to tangible goods recommendation, and pay less attention to e-commerce logistics service recommendation.In this paper, through the in-depth study of information personalized recommendation service in e-commerce environment, combined with the application background of big data: taking the user dissimilarity matrix as the recommendation model, we propose iu usercf and udb slope one recommendation algorithm.The two algorithms based on incremental update recommendation model have good scalability, can effectively deal with big data, and have high prediction accuracy.The proposed algorithm is applied to the actual system, taking e-commerce logistics service as the recommendation object and iu-usercf as the recommendation algorithm, the personalized recommendation system for e-commerce logistics service is constructed.The e-commerce logistics service recommendation system explores the application practice of recommendation algorithm under big data, and enriches the application scenarios of personalized recommendation technology.

Journal: Journal of Physics: Conference Series (2021)
Publication types: Conference Abstract/Paper;
Restoring microRNA-499-5p Protects Sepsis-Induced Lung Injury Mice Via Targeting Sox6

Background micro rnas (mi rs) are known to participate in sepsis; hence, we aim to discuss the protective effect of mi r-499-5p targeting sex-determining region y-related high-mobility-group box 6 (sox6) on sepsis-induced lung injury in mice.Methods the sepsis-induced lung injury model was established by cecal ligation and puncture.The wet/dry weight (w/d) ratio, mi r-499-5p, sox6, caspase-3 and caspase-9 expression in lung tissues of mice were tested.Lung injury score, collagen fibers and the degree of pulmonary fibrosis in lung tissues were determined.Further, the cell apoptosis in lung tissues was measured.The inflammatory factors contents and oxidative stress indices in bronchoalveolar lavage fluid (balf) and lung tissues were detected via loss- and gain-of-function assays.The targeting relation between mi r-499-5p and sox6 was verified.Results w/d ratio and sox6 were increased while mi r-499-5p was decreased in lung tissues of sepsis-induced lung injury mice.Restored mi r-499-5p or depleted sox6 alleviated lung tissues pathology, reduced lung injury score, collagen fibers, the degree of pulmonary fibrosis, tunel positive cells, caspase-3 and caspase-9 protein expression and inflammatory factors contents in balf and lung tissues as well as oxidative stress response in lung tissues of sepsis-induced lung injury mice.Mi r-499-5p targeted sox6.Conclusion high expression of mi r-499-5p can attenuate cell apoptosis in lung tissues and inhibit inflammation of sepsis-induced lung injury mice via depleting sox6, and it is a potential candidate marker and therapeutic target for sepsis-induced lung injury.

Journal: Discover Nano (formerly known as Nanoscale Research Letters) (2021)
Publication types: Research Article;
Xia-yu-xue decoction (XYXD) reduces carbon tetrachloride (CCl4)-induced liver fibrosis through inhibition hepatic stellate cell activation by targeting NF-κB and TGF-β1 signaling pathways

Background hepatic stellate cell (hsc) activation is activated mainly by endotoxin and transforming growth factor (tgf-β1) in chronic liver injury, consequently, can be important therapeutic targets.Xia-yu-xue decoction (xyxd), a classical recipe used in china to treat liver fibrosis, and has been revealed to inhibit hepatic fibrosis in animal models, the mechanism of action of xyxd remains elusive.In the present study, we evaluated whether xyxd reduced endotoxin and pro-fibrogenic pathways induced by lipopolysaccharide (lps) and tgf-β1 in hscs.Methods the in vivo effect of xyxd on fibrosis progression was assessed in mice model induced by carbon tetrachloride (ccl 4 ), the in vitro effect of xyxd on mice gfp-col-hsc cells was evaluated using lps and tgf-β1 stimulation.Results xyxd treatment reduced ccl 4 -induced liver fibrosis and decreased hepatic hydroxyproline (hyp) content, the m rna levels of smooth muscle actin (α-sma) and col 1(α1) in fibrotic liver.Xyxd suppressed nuclear factor-κb (nf-κb) activation induced by lps and tgf-β1 assessed by using nf-κb-luciferase reporter.The expression of nf-κb target genes, chemokine (c-c motif) ligand 2 (ccl2) and chemokine (c-x-c motif) ligand 2 (cxcl2) induced by lps was suppressed after xyxd treatment.The expression of tgf-β1 targets genes, col1(α1) and tissue inhibitor of metalloproteinases (timp1) induced by tgf-β1 was inhibit after xyxd treatment.Conclusion xyxd treatment attenuates liver fibrosis by inhibiting hsc activation via inhibition of nf-κb and tgf-β1 signaling pathway, thereby blocking the synthesis of col1 (α1) and timp-1.These findings from present study suggest that xyxd may be a therapeutic decoction for liver fibrosis in which nf-κb and tgf-β1 are thought to take part.

Journal: BMC Complementary Medicine and Therapies (2015)
Publication types: Research Article;
K-ras-ERK1/2 down-regulates H2A.XY142ph through WSTF to promote the progress of gastric cancer

Background histone h2ax phosphorylation at the site of tyr-142 can participates in multiple biological progressions, which is including dna repair.Ras pathway is closely involved in human cancers.Our study investigated the effects of ras pathway via regulating h2ax.Y142ph .Methods gastric cancer cell line snu-16 and mkn1 cells were transfected with ras for g12d and t35s site mutation.The phosphorylation of h2a.x y142 and erk1/2, wstf and mdm2 was detected by western blot.Cell viability, cell colonies and migration was analyzed by mtt assay, soft-agar colony formation assay, and transwell assay, respectively.The expression of ras pathway related downstream factors, eya3 and wstf was detected by q rt-pcr.The relationship between ras and downstream factors were detected by ch ip.The cell cycle progression was measured by flow cytometry.Results ras g12d/t35v transection decreased the phosphorylation of h2a.x y142 and activated phosphorylation of erk-1/2.H2a.x y142 inhibited cell viability, colonies and migration.H2a.x y142ph altered the expression of ras downstream factors.Chip assay revealed that ras g12d/t35v could bind to the promoters of these ras pathway downstream factors.Silence of eya3 increased h2a.x y142ph and inhibited cell viability, migration and percent cells in s stage.Furthermore, silence of eya3 also changed the downstream factors expression.Wstf and h2a.x y142ph revealed the similar trend and mdm2 on the opposite.Conclusion ras/erk signal pathway decreased h2a.x y142ph and promoted cell growth and metastasis.This ras regulation process was down-regulated by the cascade of mdm2-wstf-eya3 to decrease h2a.x y142ph in snu-16 cells.

Journal: BMC Cancer (2019)
Publication types: Research Article;
Propofol exerts neuroprotective functions by down-regulating microRNA-19a in glutamic acid-induced PC12 cells

Background propofol, a kind of intravenous sedative drug, is certified that exerts anti‐inflammation and antitumor functions.However, the influence of propofol in cerebral injury and the corresponding mechanism remains unexplained, that our article focuses on.Methods pc12 cells were treated with propofol and exposed in glutamic acid (glu) solutions.Cell viability, apoptotic potential, apoptosis‐related and autophagy‐linked proteins were tested via cck‐8, flow cytometry, and western blot assays.Reverse transcription‐quantitative real‐time pcr was utilized to test mi r‐19a expression in glu‐stimulated cells.Next, mi r‐19a mimic transfection was used to assess the effects of mi r‐19a on cell apoptosis and autophagy in glu or propofol treated cells.Finally, western blot was performed to test ampk and m tor pathways.Results glu exposure promoted cell apoptosis and autophagy of pc12 cells, while propofol attenuated cell apoptosis and autophagy triggered by glu.Additionally, propofol decreased the mi r‐19a expression in glu‐stimulated pc12 cells.Meanwhile, over‐expression of mi r‐19a reversed the effects of propofol on glu‐induced cell apoptosis and autophagy.Moreover, propofol potentiated ampk and m tor pathways in glu‐stimulated pc12 cells via impeding mi r‐19a expression.Conclusions these finding revealed that propofol relieved glu‐triggered apoptosis and autophagy of pc12, and activated ampk and m tor pathways by suppressing mi r‐19a expression.

Journal: Biofactors (2020)
Publication types: Research Article;
α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3

Endometrial cancer (ec) is one of the most common cancers in females.Although the diagnosis and treatment in early stages can greatly improve the survival rate of patients, the advanced ec still is lethal.Radiotherapy is widely used against ec, and it is a great challenge to find an effective way to overcome the resistance of ec during radiotherapy.Α-bisabolol is a promising drug, which has already exhibited its anti-tumor effect in some malignancies.Here we reported that α-bisabolol could inhibit the proliferation of ec cells.It is also shown that their abilities of migration and invasion were effectively reduced by α-bisabolol.Furthermore, our results also demonstrated that α-bisabolol could improve sensitivity of ec cells in radiotherapy and further inhibited the growth of ec cells.By western blot, we found the expression of matrix metalloproteinases-9 (mmp-9) and cyclin e were significantly decreased, which indicated that ec cells can be further suppressed by using α-bisabolol and radiotherapy.It is also demonstrated in our study that the rate of apoptotic cells is markedly increased in ec by using these two treatments.The significant decrease in x-linked inhibitor of apoptosis protein (xiap) and increase in caspase-3 detected in our study suggested that the enhancement of apoptosis is mediated by xiap/caspase-3 pathway, which was further confirmed by examining the downstream effectors of caspase-3, cox-2, parp and cleaved parp.In the present study, we demonstrated that α-bisabolol could enhance the sensitivity of ec cells to radiotherapy, which provide a novel alternative for overcoming radioresistance of ec cells and achieving a better outcome in radiotherapy.

Journal: Bioscience Reports (2019)
Publication types: Research Article;
MiR-182 regulates cell proliferation and apoptosis in laryngeal squamous cell carcinoma by targeting the CRR9

Background: the effect of mi r-182 on the expressions of crr9 in laryngeal squamous cell carcinoma (lscc) cells, and the impact on invasion and metastasis of lscc were investigated in the present paper.Methods: the expressions of mi r-182 in lscc tissue and cell line were detected by rt-q pcr.Mtt assay and annexin v staining were used to detect the effects of mi r-182 on tumor cells proliferation.Target gene prediction and screening, and luciferase reporter assay were designed to verify downstream target genes of mi r-182.The m rna and protein expressions of crr9 were detected by q rt-pcr and western blot.Finally, the expressions of crr9 were measured by transfecting cells with mi r-182 in mice.Results: compared with normal tissue and cell, the expressions of mi r-182 in tumor tissues and cells were much lower.Over-expressions of mi r-182 can increase apoptosis rate.Luciferase reporter assay revealed that crr9 was a downstream gene of mi r-182.Reintroduction of crr9 abolished mi r-182-induced lscc cell growth inhibition.In animal models, over-expressions of mi r-182 can reduce tumor weight and promote apoptosis.Conclusion: mi r-182 can inhibit the proliferation of lscc cells by directly inhibiting the expressions of crr9, thereby suppressing the occurrences and developments of lscc.

Journal: Bioscience Reports (2019)
Publication types: Research Article;
Linc00210 drives Wnt/β-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner

Background liver tumor initiating cells (tics) have self-renewal and differentiation properties, accounting for tumor initiation, metastasis and drug resistance.Long noncoding rnas are involved in many physiological and pathological processes, including tumorigenesis.Dna copy number alterations (cna) participate in tumor formation and progression, while the cna of lnc rnas and their roles are largely unknown.Methods lnc rna cna was determined by microarray analyses, realtime pcr and dna fish.Liver tics were enriched by surface marker cd133 and oncosphere formation.Tic self-renewal was analyzed by oncosphere formation, tumor initiation and propagation.Crispri and aso were used for lnc rna loss of function.Rna pulldown, western blot and double fish were used to identify the interaction between lnc rna and ctnnbip1.Results using transcriptome microarray analysis, we identified a frequently amplified long noncoding rna in liver cancer termed linc00210 , which was highly expressed in liver cancer and liver tics.Linc00210 copy number gain is associated with its high expression in liver cancer and liver tics.Linc00210 promoted self-renewal and tumor initiating capacity of liver tics through wnt/β-catenin signaling.Linc00210 interacted with ctnnbip1 and blocked its inhibitory role in wnt/β-catenin activation.Linc00210 silencing cells showed enhanced interaction of β-catenin and ctnnbip1, and impaired interaction of β-catenin and tcf/lef components.We also confirmed linc00210 copy number gain using primary hepatocellular carcinoma (hcc) samples, and found the correlation between linc00210 cna and wnt/β-catenin activation.Of interest, linc00210, ctnnbip1 and wnt/β-catenin signaling targeting can efficiently inhibit tumor growth and progression, and liver tic propagation.Conclusion with copy-number gain in liver tics, linc00210 is highly expressed along with liver tumorigenesis.Linc00210 drives the self-renewal and propagation of liver tics through activating wnt/β-catenin signaling.Linc00210 interacts with ctnnbip1 and blocks the combination between ctnnbip1 and β-catenin, driving the activation of wnt/β-catenin signaling.Linc00210 -ctnnbip1-wnt/β-catenin axis can be targeted for liver tic elimination.

Journal: Molecular Cancer (2018)
Publication types: Research Article;