syedzayyan/paper_mill_benchmark huggingface dataset:
Clinical and laboratory predictors of fetal and neonatal alloimmune thrombocytopenia.

Fetal and neonatal alloimmune thrombocytopenia (fnait) is the most common cause of intracranial hemorrhage (ich) in thrombocytopenic term infants.We investigated clinical and laboratory predictors of severe fnait in a tertiary care referral center.Study design and methods retrospective cohort study over a 30-year period.We defined fnait as recurrence of neonatal thrombocytopenia in a subsequent pregnancy; and severe outcomes as any of: (1) a birth platelet count below 20 × 109/l; (2) ich or (3) fetal death.We used a generalized estimating equations analysis and classification tree analysis to identify risk factors for severe fnait in a subsequent pregnancy.Results during index pregnancies (n = 135 in 131 mothers), 71 infants (52.6%) had severe outcomes including a platelet count <20 × 109/l (n = 45), fetal or neonatal ich (n = 32), or fetal death (n = 4).During subsequent pregnancies (n = 72), 15 infants (20.8%) had severe outcomes including birth platelets <20 × 109/l (n = 10), ich (n = 2), or death (n = 3).Forty-two women (58.3%) received antenatal intravenous immune globulin (ivig) during subsequent pregnancies.Eight mothers (n = 9 infants) had severe fnait outcomes despite receiving antenatal ivig.Maternal antibodies to human platelet antigens (hpa) was the only independent predictor of severe fnait in a subsequent pregnancy (or = 25.3, p = .004).Nevertheless, one of 43 infants from antibody-negative mothers had a severe outcome.Conclusions the presence of anti-hpa is highly indicative of the diagnosis of severe fnait; however, we observed one infant who had severe fnait recurrence, defined using strict clinical criteria, without a maternal antibody.Improved diagnostic and therapeutic strategies are needed to prevent severe fnait in high-risk mothers.

Journal: Transfusion (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Pulsatile load and wasted pressure effort are reduced following an acute bout of aerobic exercise.

Following aerobic exercise, sustained vasodilation and concomitant reductions in total peripheral resistance (tpr) result in a reduction in blood pressure that is maintained for two or more hours.However, the time course for postexercise changes in reflected wave amplitude and other indices of pulsatile load on the left ventricle have not been thoroughly described.Therefore, we tested the hypothesis that reflected wave amplitude is reduced beyond an hour after cycling at 60% v̇o2peakfor 60 min.Aortic pressure waveforms were derived in 14 healthy adults (7 men, 7 women; 26 ± 3 yr) from radial pulse waves acquired via high-fidelity applanation tonometry at baseline and every 20 min for 120 min postexercise.Concurrently, left ventricle outflow velocities were acquired via doppler echocardiography and pressure-flow analyses were performed.Aortic characteristic impedance (zc), forward (pf) and backward (pb) pulse wave amplitude, reflected wave travel time (rwtt), and wasted pressure effort (wpe) were derived.Reductions in aortic blood pressure, zc, pf, and pb were all sustained postexercise whereas increases in rwtt emerged from 60 to 100 min post exercise (all p< 0.05).Wpe was reduced by ∼40% from 40 to 100 min post exercise (all p< 0.02).Stepwise multiple regression analysis revealed that the peak δwpe was associated with δrwtt (β = -0.57,p= 0.003) and δpb (β = 0.52,p= 0.006), but not δcardiac output, δtpr, δzc, or δpf.These results suggest that changes in pulsatile hemodynamics are sustained for ≥100 min following moderate intensity aerobic exercise.Moreover, decreased and delayed reflected pressure waves are associated with decreased left ventricular wasted effort after exercise.new & noteworthywe demonstrate that pulsatile load on the left ventricle is diminished following 60 min of moderate intensity aerobic exercise.During recovery from exercise, the amplitude of the forward and backward traveling pressure waves are attenuated and the arrival of reflected waves is delayed.Thus, the work imposed upon the left ventricle by reflected pressure waves, wasted pressure effort, is decreased after exercise.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Double-Layered Films Based on Furcellaran, Chitosan, and Gelatin Hydrolysates Enriched with AgNPs in Yerba Mate Extract, Montmorillonite, and Curcumin with Rosemary Essential Oil.

Double-layered active films based on furcellaran (1st layer-fur), chitosan, and gelatin hydrolysates (2nd layer-chit+hgel) were successfully prepared.Bioactive ingredients were added to the 1st film layer: ag nps, which were synthesized in situ with yerba mate extract; montmorillonite clay (mmt); and different loads of ethanolic curcumin (cur) extract enriched with rosemary essential oil (reo).Sem images confirmed the presence of ag nps with a size distribution of 94.96 ± 3.33 nm throughout the films, and afm and sem photos indicated that the higher substance concentrations had rougher and more porous film microstructures.However, the water vapor transmission rate was reduced only at the lowest load of this ingredient.Despite the tensile strength of the films having decreased, the incorporation of the compounds showed a tendency towards reducing the modulus of elasticity, resulting in a lower stiffness of the composites.The addition of cur and ag nps improved the uv light barrier properties of the materials.The presented films showed quick reactions to changes in the p h value (from orange to red along with an increase in p h from 2 to 10), which indicates their potential use as indicators for monitoring the freshness of food products.Composite no.2 showed the highest antimicrobial potential, while none of the presented films showed an antifungal effect.Finally, the antioxidant activities of the films increased dramatically at higher ag np and cur loads, suggesting an outstanding potential for active food packaging applications.

Journal: Polymers (2022)
Publication types: Journal Article
Pregnancy outcome after hysteroscopic myomectomy.

The objective of this longitudinal retrospective study was to evaluate the influence of submucosal myomas on pregnancy outcome in infertile patients after resectoscopic myomectomy.One-hundred and four women with at least a 1-year-long history of infertility and the presence of submucosal myomas as the only cause of infertility were selected after surgical treatment.Pregnancy, delivery and abortion rates were investigated.Patients were divided into three groups according to the myoma classification (g0, g1 and g2).Gestational outcomes were analyzed in the three groups correlated by size, location and number of fibroids.The total pregnancy rate was 85.8% and no difference was shown regarding myoma classification (g0 82.05% versus g1 87.09% versus g2 88.2%; p = ns).Pregnancy and delivery rates were not significantly related to the number, localization or diameter of the fibroids.The abortion rate was not statistically influenced by myoma type, but it was significantly inter-related with myomas situated in the anterior uterine wall (p = 0.03).Pre-term delivery was significantly influenced by myomas localized in the fundic wall (p = 0.02).Caesarean section rates were not affected by the characteristics of the myomas.Our results support the idea that resectoscopic myomectomy should be offered to infertile women who wish to become pregnant independently of their localization and number.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2014)
Publication types: Journal Article
Relationship between the place of living and mortality in patients with advanced heart failure.

Social and environmental factors in advanced heart failure (hf) patients may be crucial to cope with the end stages of the disease.This study analyzes health inequalities and mortality according to place of residence (rural vs urban) in hf patients at advanced stages of the disease.Methods population-based cohort study including 1148 adult patients with hf attended in 279 primary care centers.Patients were followed for at least 1 year after reaching new york heart association iv functional class, between 2010 and 2014.Data came from primary care electronic medical records.Cox regression models were applied to determine the hazard ratios (hr) of mortality.Results mean age was 81.6 (sd 8.9) years, and 62% were women.Patients in rural areas were older, particularly women aged > 74 years (p = 0.036), and presented lower comorbidity.Mortality percentages were 59 and 51% among rural and urban patients, respectively (p = 0.030).Urban patients living in the most socio-economically deprived neighborhoods presented the highest rate of health service utilization, particularly with primary care nurses (p-trend < 0.001).Multivariate analyses confirmed that men (hr 1.60, 95% confidence interval (ci) 1.34-1.90), older patients (hr 1.05, 95% ci 1.04-1.06), charlson comorbidity index (hr 1.16, 95% ci 1.11-1.22), and residing in rural areas (hr 1.35, 95% ci 1.09 to 1.67) was associated with higher mortality risk.Conclusions living in rural areas determines an increased risk of mortality in patients at final stages of heart failure.

Journal: BMC family practice (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Morphology of the Trabecular Meshwork and Schlemm's Canal in Posner-Schlossman Syndrome.

The purpose of this study was to investigate trabecular meshwork (tm) and schlemm's canal (sc) morphology in posner-schlossman syndrome (pss).Methods forty-five patients with pss were recruited.Tm thickness and length as well as sc area and diameter of both affected and fellow eyes were assessed using swept-source optical coherence tomography.Results tm thickness (108.24 ± 28.29 μm vs.89.36 ± 25.82 μm, p = 0.014), sc area (6010.90 ± 1287.54 μm2 vs.5445.69 ± 1368.89 μm2, p = 0.003), and sc diameter (239.38 ± 60.17 μm vs.217.76 ± 60.79 μm, p = 0.010) were significantly greater in the affected eyes.Furthermore, tm thickness (113.32 ± 30.03 μm vs.89.00 ± 26.99 μm, p = 0.046), sc area (6216.32 ± 1267.87 μm2 vs.5476.40 ± 1390.15 μm2, p = 0.001), and sc diameter (246.82 ± 64.12 vs.212.53 ± 64.29 μm, p = 0.001) were significantly greater in the affected eyes than in the fellow eyes in the ocular hypertension (oht) subgroup (affected eye with intraocular pressure [iop] > 21 mm hg).However, those differences were not noted in the ocular normal tension (ont) subgroup (affected eye with iop ≤ 21 mm hg, all p > 0.05).Conclusions tm edema might play a role in the iop elevation in pss.The edematous tm could make controlling iop of the affected eyes difficult.When tm edema is relieved, iop of the affected eyes can reduce to normal spontaneously or with iop-lowing medications.

Journal: Investigative ophthalmology & visual science (2022)
Publication types: Comparative Study;Journal Article;Research Support, Non-U.S. Gov't
Brain MRI findings of prelingually deaf children and cochlear implant outcome: Preliminary results.

To estimate the incidence of brain abnormalities in a cohort of prelingually deaf children and whether these abnormalities can impact the hearing outcomes of patients eligible for cochlear implantation (ci).Methods we performed a retrospective review of consecutive medical charts of prelingually deaf children under 12 years of age who underwent brain magnetic resonance imaging (mri) during their preoperative workup for ci surgery.We used the category of auditory performance (cap) test and the speech intelligibility rating (sir) test to assess the hearing and speech performance of the children, respectively.Results the mris of 285 patients, 174 boys and 111 girls with a mean age of 36.4 (±16) months, were evaluated for this study.We identified 31 patients with abnormal findings (10.88%): (17/31) (54.8%) had mri brain abnormalities, (9/31) (29%) had inner ear anomalies, and (5/31) (16.1%) had both inner ear and brain abnormalities.The most frequent inner ear anomaly was an enlarged vestibular aqueduct, while white matter lesions were the most common brain abnormality.The cap and sir mean score of patients with inner ear anomalies was slightly, but not significantly, higher than those of patients with brain abnormalities.Conclusion cap and sir scores were not significantly different in children with brain abnormalities than inner ear anomalies.These patients can still benefit from ci to improve their overall hearing and speech performance.

Journal: International journal of pediatric otorhinolaryngology (2022)
Publication types: Journal Article
Amentoflavone Exerts Anti-Neuroinflammatory Effects by Inhibiting TLR4/MyD88/NF-κB and Activating Nrf2/HO-1 Pathway in Lipopolysaccharide-Induced BV2 Microglia.

Amentoflavone, a natural biflavone, exerts anti-inflammation, antioxidation, and antiapoptosis effects on many diseases.However, the mechanism of amentoflavone on neuroinflammation-related diseases has not been comprehensively examined clearly.Methods bv2 microglial cells were treated with amentoflavone (10μm), followed by lipopolysaccharide (lps).Microglial activation and migration ability and the expression of proinflammatory cytokines and other signaling proteins were determined using immunohistochemistry, immunofluorescence, quantitative real-time polymerase chain reaction, western blotting, enzyme-linked immunosorbent assay, and wound-healing assays.Results amentoflavone restored lps-induced microglia activation, migration, and inflammation response which depends on regulating toll-like receptor 4 (tlr4)/myeloid differentiation factor 88 (my d88)/nuclear factor kappa b (nf-κb) pathway.In addition, amentoflavone also enhanced nuclear factor erythroid 2-related factor 2 (nrf2)/heme oxygenase-1 (ho-1) levels in lps-treated bv2 microglial cells.Conclusions amentoflavone ameliorated lps-induced neuroinflammatory response and oxidative stress in bv2 microglia.These data provide new insight into the mechanism of amentoflavone in the treatment of neuroinflammation-related diseases.Therefore, amentoflavone may be a potential therapeutic option for neurological disorders.

Journal: Mediators of inflammation (2022)
Publication types: Journal Article
Inflammatory Biochemical Mediators and Their Role in Myofascial Pain and Osteopathic Manipulative Treatment: A Literature Review.

Chronic inflammatory pain conditions, specifically myofascial pain (mfp), account for an overwhelming percentage of office visits every day.The combination of the high cost of its treatment and frequent patient visits makes mfp a critical pathology to be investigated.Sharpening our understanding of the molecular mechanisms within mfp will expedite the enhancement of therapeutic approaches.Inflammation plays a critical role in the pathophysiology of mfp.The chief inflammatory mediators of interest in this review related to mfp are interleukin 1β (il-1β), il-6, and tumor necrosis factor-α (tnf-α).This review aimed to determine the impact of inflammatory mediators on fibroblasts and satellite cells, specifically their role in muscle injury and regeneration.Blocking pro-inflammatory mediators such as il-1β, il-6, and tnf-α in these cell types could prove to be an effective treatment for mfp.An osteopathic manipulative treatment (omt) modality, specifically indirect counterstrain therapy, was investigated in the hopes of elucidating a reduction in particular cytokines.In addition, myofascial release (mfr) therapies (omt modality) were explored as a potentially effective treatment through the acceleration of wound healing, stimulation of muscle regeneration, and decreased inflammation via altered fibroblast activity.Pharmacologic agents such as non-steroidal anti-inflammatory drugs (nsaids) are commonly used to treat mfp but have a higher adverse side effect profile compared to omt therapy.The optimal management of mfp is likely multifactorial, and more treatment modalities must be explored.This literature review analyzed 17 peer-reviewed articles specifically related to mfp management and the role of inflammation in mfp.Chronic inflammation from other etiologies was excluded.Our aim was to elucidate the biochemical mechanisms underlying mfp and inflammation in an effort to promote the medical community's understanding of treatment modalities for this chronic condition.This study revealed that various omt techniques such as mfr and counterstrain lead to changes on the cellular level in mfp.Discovering similar effects on biochemical inflammatory markers with non-pharmacologic treatment modalities was an exciting revelation and one that could potentially change the way physicians address pain management.

Journal: Cureus (2022)
Publication types: Journal Article;Review
Application of Metabolomics to Renal and Cardiometabolic Diseases.

Metabolomics has been increasingly applied to study renal and related cardiometabolic diseases, including diabetes and cardiovascular diseases.These studies span cross-sectional studies correlating metabolites with specific phenotypes, longitudinal studies to identify metabolite predictors of future disease, and physiologic/interventional studies to probe underlying causal relationships.This chapter provides a description of how metabolomic profiling is being used in these contexts, with an emphasis on study design considerations as a practical guide for investigators who are new to this area.Research in kidney diseases is underlined to illustrate key principles.The chapter concludes by discussing the future potential of metabolomics in the study of renal and cardiometabolic diseases.

Journal: Methods in molecular biology (Clifton, N.J.) (2020)
Publication types: Journal Article
A Novel Multiepitope Vaccine Against Bladder Cancer Based on CTL and HTL Epitopes for Induction of Strong Immune Using Immunoinformatics Approaches.

Bladder cancer is well-known cancer in two forms of muscle-invasive and non-muscle-invasive bladder cancer which is responsible for annual deaths worldwide.Common therapies methods are somewhat successful; however, these methods have the limitations such as the side effects of chemotherapy which necessitate the requirement for new preventive methods against bladder cancer.Hence, we explain a novel designed multi-epitope vaccine against bladder cancer using the immunoinformatics tool.Three well-known blcap, pram, and bage4 antigens were evaluated due to most repetitive ctl and htl epitopes binding.Ifnγ and il10 inducer potential of selected epitopes were investigated, as well as liner and conformational b-cell epitopes.Human beta-defensin 3 and padre sequence were added to construct as adjuvants, along with eaaak, aay, and gggs linkers to fuse ctl and htl epitopes.Results showed this construct encodes a soluble, non-toxic, and non-allergic protein with 70 k da molecular weight.Modeled 3d structure of vaccine was docked whit toll-like receptors (tlr) of 7/8.Docking, molecular dynamics simulation and mmbpsa analysis confirmed stability of vaccine-tlr complexes.The immunogenicity showed this construct could elicit humoral and cellular immune responses.In silico and immunoinformatics evaluations suggest that this construct is a recombinant candidate vaccine against bladder cancer.Supplementary information the online version contains supplementary material available at .

Journal: International journal of peptide research and therapeutics (2022)
Publication types: Journal Article
Effective maNagement of depression among patients witH cANCEr (ENHANCE): a protocol for a hybrid systematic review and network meta-analysis of randomised controlled trials of interventions for depressive symptoms.

Depression is common among patients with cancer and is associated with lower treatment participation, lower satisfaction with care, poorer quality of life, greater symptom burden and higher healthcare costs.Various types of interventions (e.g.Pharmacological, psychotherapy) are used for the treatment of depression.However, evidence for these among patients with cancer is limited.Furthermore, the relative effectiveness and acceptability of different approaches are unknown because a direct comparison between all available treatments has not been carried out.We will address this by conducting a network meta-analysis (nma) of interventions for depression among people with cancer using a hybrid overview of reviews and systematic review methodology.Methods we will search for and extract data from systematic reviews of randomised controlled trials (rcts) of depression interventions for patients with cancer from inception, before performing a supplemental search for more recent rcts.We will include rcts comparing pharmacological, psychotherapy, exercise, combination therapy, collaborative care or complementary and alternative medicine interventions with pill placebo, no treatment, waitlist, treatment as usual or minimal treatment control groups, or directly in head-to-head trials, among adults who currently have cancer or have a history of any cancer and elevated depressive symptoms (scores above a cut-off on validated scales or meeting diagnostic criteria).Our primary outcomes will be change in depressive symptoms (standardised mean difference) and intervention acceptability (% who withdrew).Our secondary outcomes will be 6-month change in depressive symptoms, health-related quality of life, adverse events and mortality.We will independently screen for eligibility, extract data and assess risk of bias using the ro b 2 tool.We will use frequentist random-effects multivariate nma in stata, rankograms and surface under the cumulative ranking curves to synthesise evidence and obtain a ranking of intervention groups.We will explore heterogeneity and inconsistency using local and global measures and evaluate the credibility of results using the confidence in network meta-analysis (cine ma) framework.Discussion our findings will provide the best available evidence for managing depression among patients with cancer.Such information will help to inform clinical guidelines, evidence-based treatment decisions and future research by identifying gaps in the current literature.Systematic review registration submitted to prospero (record number: 290145), awaiting registration.

Journal: Systematic reviews (2022)
Publication types: Clinical Trial Protocol;Journal Article;Research Support, Non-U.S. Gov't
Anaplastic Lymphoma Kinase Tyrosine Kinase Inhibitor-Associated Cardiotoxicity: A Recent Five-Year Pharmacovigilance Study.

Clinical trials frequently reported anaplastic lymphoma kinase tyrosine kinase inhibitors (alk-tkis) associated with cardiac adverse drug events (aes) but minimal postmarketing data.We aimed to research real-world cardiac disorders associated with alk-tkis based on the food and drug administration adverse event reporting system (faers).methods:extract reports from the faers from the first quarter of 2016 to the second quarter of 2021 were obtained.Data mining of cardiac disorders associated with alk-tkis was carried out using disproportionality analysis to determine the clinical characteristics of aes.results:in total, 605 cases were screened out.These events were found to be more prevalent in patients ≥45 years (50.74%) and women (50.74%).The onset time of cardiac disorders was variable and concentrated within 2 months, with a median time of 33 days.The outcomes tended to be poor, with 20.93% fatality proportion.Cardiac arrhythmia was a common adverse event of alk-tkis, especially bradycardia.Crizotinib and lorlatinib showed positive signals in cardiac disorders, especially in heart failure, and brigatinib presented no signals.The study also found that myocarditis caused by ceritinib and cardiomyopathy caused by lorlatinib may be potential new adverse drug reactions.conclusion:alk-tkis were reported more frequently in cardiotoxicity than other drugs and could often manifest earlier.We also found potential new ae signals in specific drugs and need more clinical studies to confirm.Our study helps fill the safety information of alk-tkis in the heart and provides directions for further research.

Journal: Frontiers in pharmacology (2022)
Publication types: Journal Article