syedzayyan/paper_mill_benchmark huggingface dataset:
Catalytic Nanomedicine - A new Approach and Solution for Chronic Ulcers: Case Series.

Chronic ulcers are a major public health problem, due to their chronic nature, their poor response to treatment, the high frequency of recurrences, and their affection to the patient's quality of life.Even with the development of new therapies in the field of chronic wound care, chronic ulcers remain a clinical problem.As a novel branch of research, catalytic nanomedicine has offered promising results in disinfection and treatment of chronic wounds through the use of bionanocatalysts, organically functionalized mesoporous nanostructured materials with catalytic properties.Particularly, cu/ti o2-si o2mixed oxide bionanocatalysts have shown favorable results for chronic ulcer healing.In this work, we present the treatment of 15 patients (8 females and 7 males, mean age of 69.59 ± 12.07 years old) affected with chronic ulcers (wound age ranging from 4 months to 10 years old, mean size of 12.94 ± 18.20 cm2) by the administration of cu/ti o2-si o2bionanocatalysts embedded in a nanoemulsion matrix.In all cases, complete epithelialization and healing of the lesions was achieved (healing time from 3 to 35 weeks), without the appearance of side effects.Wound healing time was analyzed in the context of initial wound size, wound's age, patient's age, and concomitant conditions, being wound size and patient's age the main factor affecting the duration of the treatment with the bionanocatalysts.

Journal: The international journal of lower extremity wounds (2022)
Publication types: Journal Article
Randomized double-blind vehicle controlled study of the effects of topical acetyl zingerone on photoaging.

Acetyl zingerone (az), a derivative of the phytochemical zingerone from zingiber officinale (ginger), is a novel compound that is purported to have antiaging properties.The objective of this clinical study was to assess the role of acetyl zingerone in its ability to improve the appearance of facial skin wrinkles, redness, pigmentation, and photoaging was assessed.Methods thirty-one healthy participants (age 44 ± 7 years) were randomized in blinded fashion to apply either 1% az or placebo, consisting of the vehicle base cream, to the full face twice daily for 8 weeks with a total of 3 visits.Signs of photoaging, including wrinkles, dyspigmentation, and redness were assessed with facial image analysis photography and software.Results there was a significant decrease in average wrinkle severity (p = .019; mean=-25.7% change), total wrinkle volume (p = .003; mean=-30.1% change), pigment intensity (p = .021; mean=-25.6% change), and redness intensity (p = .035; mean=-20.7% change) in the az group by 8 weeks compared with the placebo.No significant itching, burning, or stinging was noted by study participants.There was also no significant difference between both groups in the clinical assessment of scaling, erythema, hypopigmentation, or hyperpigmentation.Conclusions and relevance topical az improves photodamage and decreases the appearance of wrinkles, dyspigmentation, and redness intensity when compared to placebo (vehicle) formulation.Acetyl zingerone is well tolerated with daily use.

Journal: Journal of cosmetic dermatology (2021)
Publication types: Journal Article;Randomized Controlled Trial
The coronary capillary bed and its role in blood flow and oxygen delivery: A review.

The assumption that the coronary capillary blood flow is exclusively regulated by precapillary vessels is not supported by recent data.Rather, the complex coronary capillary bed has unique structural and geometric characteristics that invalidate many assumptions regarding red blood cell (rbc) transport, for example, data based on a single capillary or that increases in flow are the result of capillary recruitment.It is now recognized that all coronary capillaries are open and that their variations in flow are due to structural differences, local o2demand and delivery, and variations in hematocrit.Recent data reveal that local mechanisms within the capillary bed regulate flow via signaling mechanisms involving rbc signaling and endothelial-associated pericytes that contract and relax in response to humoral and neural signaling.The discovery that pericytes respond to vasoactive signals (e.g., nitric oxide, phenylephrine, and adenosine) underscores the role of these cells in regulating capillary diameter and consequently rbc flux and oxygen delivery.Rbcs also affect blood flow by sensing po2and releasing nitric oxide to facilitate relaxation of pericytes and a consequential capillary dilation.New data indicate that these signaling mechanisms allow control of blood flow in specific coronary capillaries according to their oxygen requirements.In conclusion, mechanisms in the coronary capillary bed facilitate rbc density and transit time, hematocrit, blood flow and o2delivery, factors that decrease capillary heterogeneity.These findings have important clinical implications for myocardial ischemia and infarction, as well as other vascular diseases.

Journal: Anatomical record (Hoboken, N.J. : 2007) (2022)
Publication types: Journal Article;Review
Development and Characterization of Natural-Fiber-Based Composite Panels.

The emphasis on sustainability in materials related to the construction and transportation sectors has renewed interest in the usage of natural fibers.In this manuscript, a different perspective is taken in adopting oil palm fibers (opf) to develop composite panels and understand their acoustic, mechanical, and water susceptibility (including warm water analysis) properties to provide an insight into the potential of these panels for further exploration.The binder for these composite panels is a water-based acrylic resin, and for reinforcement purposes, fly ash and other metal oxides are used.It is shown that the presence of fibers positively influences the acoustic absorption coefficient in the critical mid-frequency range of 1000-3000 hz.Even the noise reduction coefficient values highlighting the octave band are higher by more than 50% in the presence of fibers as compared to traditional refractory boards.Quasistatic indentation and drop-weight tests have also highlighted the excellent performance of the composite panels developed in this work.Though the water immersion tests on composite panels and subsequent analysis showed relatively minor changes in their performance, the immersion of the panels in caustic warm water for 56 days has resulted in their severe degradation with a loss of more than 65% in flexural strength.

Journal: Polymers (2022)
Publication types: Journal Article
Down-Regulation of DDR1 Induces Apoptosis and Inhibits EMT through Phosphorylation of Pyk2/MKK7 in DU-145 and Lncap-FGC Prostate Cancer Cell Lines.

In cancer cells, re-activation of epithelial-mesenchymal transition (emt) program through discoidin domain receptor1 (ddr1) leads to metastasis.Ddr1-targeted therapy with si rna might be a promising strategy for emt inhibition.Therefore, the aim of this study was to investigate the effect of ddr1 knockdown in the emt, migration, and apoptosis of prostate cancer cells.For this purpose, the expression of ddr1 was down regulated by the si rna approach in lncap-fgc and du-145 prostate cancer cells.Methods immunocytochemistry was carried out for the assessment of emt.E-cadherin, n-cadherin, bax, bcl2, and the phosphorylation level of proline-rich tyrosine kinase 2 (pyk2) and map kinase kinase 7 (mkk7) was determined using the western blot.Wound healing assay was used to evaluate cell migration.Flow cytometry was employed to determine the apoptosis rate in si rna-transfected cancer cells.Results our findings showed that the stimulation of ddr1 with collagen-i caused increased phosphorylation of pyk2 and mkk7 signaling molecules that led to the induction of emt and migration in du-145 and lncap- fgc cells.In contrast, ddr1 knockdown led to significant attenuation of emt, migration, and phosphorylation levels of pyk2 and mkk7.Moreover, ddr1 knockdown via induction of bax expression and suppression of bcl-2 expression induces apoptosis.Conclusion collectively, our results indicate that the ddr1 targeting with si rna may be beneficial for the inhibition of emt and the induction of apoptosis in prostate cancer.

Journal: Anti-cancer agents in medicinal chemistry (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Physiological and transcriptional responses of Dictyosphaerium sp. under co-exposure of a typical microplastic and nonylphenol.

Microplastics (mps) and nonylphenol (np) are typical pollutants that are frequently detected in aquatic environments and can pose a risk to aquatic organisms.However, the responses of algae, the producers in aquatic ecosystems, to mp and np co-exposure have not been extensively investigated.In this study, polystyrene (ps, 50 mg/l) was selected as a representative mp to evaluate its short-term effects on algae treated with np (4 mg/l).The results showed that ps mitigated the toxicity of np to algae after 96 h of exposure, as illustrated by the higher cell densities and pigment concentrations, as well as lower extracellular protein contents and better integrity of intracellular structures, in algae subjected to ps + np treatment compared with those subjected to np treatment.Moreover, the upregulated expression of genes involved in photosynthesis and downregulated expression of ribosomal genes as well as genes encoding atpase and antioxidase, analyzed through rna-sequencing analysis, further indicated the potential repair and defense mechanisms of ps in np-treated algae.

Journal: Environmental research (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Photocatalytic degradation of hydroxychloroquine using ZnO supported on clinoptilolite zeolite.

The objective of this work was to evaluate the photocatalytic activity of zinc oxide catalysts supported on natural zeolite clinoptilolite for photocatalytic degradation of the drug hydroxychloroquine, used in the treatment of malaria and which has been tested in the treatment of covid-19.To synthesize 10%zn ocp and 15%zn ocp catalysts, the wet impregnation methodology was used.The raw and synthesized catalysts were characterized by xrd, sem, xrf, bet, drs, pcz, ft-ir and pl.The degradation of hydroxychloroquine was calculated using uv-vis absorption from the samples before and after the photocatalytic process.The maximum percentage of degradation (96%) was obtained with the operational parameters of c0= 10 mg l-1; ccat= 2 g l-1of 15%zn ocp; p h = 7.5; uv-a radiation.Ecotoxicological tests against the bioindicators lactuca sativa and artemia salina confirmed the reduction of effluent toxicity after treatment.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research (2021)
Publication types: Journal Article
Coronary atherosclerosis severity is closely associated with decreased GLP-1R positivity among CD16+pro-inflammatory and patrolling monocyte subsets.

And aims glucagon like peptide-1 receptor (glp-1r) activation reduces pro-inflammatory responses of human monocytes, their accumulation in the vascular wall and foam cell formation inhibiting atherosclerogenesis.This suggests that reduction of circulating glp-1-1r positive monocytes may have pro-atherogenic effects.It is unknown whether different cd14/cd16 monocytes subsets display glp-1r and whether their relative proportions correlate with atherosclerosis severity.We evaluated the association between glp-1r positivity in different cd14/cd16 monocyte subsets and coronary atherosclerosis severity.Methods relative amounts of classical (cd14+/cd16-), intermediate pro-inflammatory (cd14+/cd16+) and non-classical patrolling (cd14-/cd16+) subsets of total circulating monocytes and the proportions of glp-1r positive monocytes in these subsets were determined in 13 control subjects and 10 dyslipidemic ischemic heart disease (ihd) patients with severe angiographic proven coronary atherosclerosis using flow cytometry analysis.Atherosclerosis severity was calculated by syntax score.Results in univariable analysis, severe atherosclerosis was associated with decreased proportion of classical monocytes and two fold increased cd16+pro-inflammatory and patrolling subsets as compared with controls (p = 0.01, p = 0.02 and p = 0.01, respectively).Frequency of glp-1r positive monocytes was decreased in both cd16+subsets (p = 0.02 and p = 0.05, respectively) and negatively correlated with atherosclerosis severity (r = -0.65, p = 0.005 and r = -0.44, p = 0.05, respectively).Conclusions increased skewing of the classical monocyte population toward cd16+pro-inflammatory and patrolling subsets accompanied by decreased in glp-1r positivity are associated with coronary atherosclerosis severity in ihd patients with dyslipidemia.Although the effect of potential confounders cannot be ruled out, our data suggest that failure of glp-1r-dependent anti-inflammatory/anti-atherogenic control results in innate immune system dysfunction and can promote atherosclerogenesis.

Journal: Atherosclerosis plus (2021)
Publication types: Journal Article
Direct Oral Anticoagulants in Patients on Chronic Dialysis and Concomitant Atrial Fibrillation: A Common Clinical Impasse.

The most frequent arrhythmia treated is atrial fibrillation (af), which necessitates the use of oral anticoagulants (oacs) to reduce the risk of thromboembolism and stroke.Patients with chronic kidney disease are more likely to develop af, with a 10% frequency among those on chronic dialysis.Warfarin is the most widely prescribed oac for individuals with end-stage kidney disease (eskd).On the other hand, direct oacs (doacs) are generally safer than warfarin, with fewer fatal bleeding events and a fixed dose that does not require close international normalized ratio (inr) monitoring.For those patients, warfarin and apixaban appear to be fda-approved, whereas dabigatran, rivaroxaban, and edoxaban are not recommended yet.Due to a lack of large randomized studies, data from major trials cannot be extended to dialysis patients.In this review, we summarize the available data and literature referring to patients on chronic hemodialysis with concomitant af.Due to the scarcity of data, we try to assist clinicians in selecting the appropriate therapy according to the specific characteristics of each patient.Finally, future directions are provided in two key areas of focus: left atrial appendage closure therapies and genetic research.

Journal: Frontiers in bioscience (Scholar edition) (2022)
Publication types: Journal Article;Review
Single administration of resveratrol improves social behavior in adult mouse models of autism spectrum disorder.

Resveratrol (rsv) is a natural polyphenol present in grapes, the skin of peanuts, and several other plants with many health benefits.Autism spectrum disorder (asd) is a neurodevelopmental disorder that may be linked to neural and synaptic development impairments.The present study aimed to analyze the preventive effects of rsv on the development of asd-like behavior, usingoxytocin receptor geneknockout (oxtr-ko) and valproic acid-induced asd (vpa-asd) model mice.Genetic deficiencies in oxtrare suggested to be involved in asd etiology.Twenty-four hours after a single rsv injection to the oxtr-ko mice, the social impairments caused by oxtr deficiency were ameliorated.Rsv also improved social impairments in the vpa-asd mice.Administration of rsv up-regulatedsilent information regulator 1(sirt1)gene andearly growth response factor 3(egr3) gene expressions in the amygdala of the oxtr-ko mice.Our data suggest that rsv may have therapeutic effects on asd with multiple targets.

Journal: Bioscience, biotechnology, and biochemistry (2020)
Publication types: Journal Article
Development of a primary care pandemic plan informed by in-depth policy analysis and interviews with family physicians across Canada during COVID-19: a qualitative case study protocol.

Introduction given the recurrent risk of respiratory illness-based pandemics, and the important roles family physicians play during public health emergencies, the development of pandemic plans for primary care is imperative.Existing pandemic plans in canada, however, do not adequately incorporate family physicians' roles and perspectives.This policy and planning oversight has become increasingly evident with the emergence of the novel coronavirus disease, covid-19, pandemic.This study is designed to inform the development of pandemic plans for primary care through evidence from four provinces in canada: british columbia, newfoundland and labrador, nova scotia, and ontario.Methods and analysis we will employ a multiple-case study of regions in four provinces.Each case consists of a mixed methods design which comprises: (1) a chronology of family physician roles in the covid-19 pandemic response; (2) a provincial policy analysis; and (3) qualitative interviews with family physicians.Relevant policy and guidance documents will be identified through targeted, snowball and general search strategies.Additionally, these policy documents will be analysed to identify gaps and/or emphases in existing policies and policy responses.Interviews will explore family physicians' proposed, actual and potential roles during the pandemic, the facilitators and barriers they have encountered throughout and the influence of gender on their professional roles.Data will be thematically analysed using a content analysis framework, first at the regional level and then through cross-case analyses.Ethics and dissemination approval for this study has been granted by the research ethics of british columbia, the health research ethics board of newfoundland and labrador, the nova scotia health authority research ethics board and the western university research ethics board.Findings will be disseminated via conferences and peer-reviewed publications.Evidence and lessons learnt will be used to develop tools for government ministries, public health units and family physicians for improved pandemic response plans for primary care.

Journal: BMJ open (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Medical Theatre as an Innovative Pedagogical Strategy in Medical Simulation.

Medical education has overshadowed the importance for interpersonal abilities in modern medicine practice.In this work, we report an innovative strategy to teach, practice, and evaluate communication and empathy abilities, based on medical theater.This approach was based on interdisciplinary effort between medicine, performing arts, and bioethics faculty.Development and first pilot experience results are here reported.A multidisciplinary team was established with the objective to structure the methodology where simulated clinical consultations were performed: two interviews took place, each with one medical student as physician and one performing arts student as simulated patient.Thirty students and 7 faculty members participated as spectators.Students received immediate feedback and they qualitatively evaluated the global experience.We conclude that medical theater methodology is a developmental strategy that could promote integral acquisition of communication competences.Supplementary information the online version contains supplementary material available at .

Journal: Medical science educator (2022)
Publication types: Editorial
Scattering by a rigid sphere of audio sound generated by a parametric array loudspeaker.

This work investigates the scattering by a rigid sphere of audio sound generated by a parametric array loudspeaker (pal).A computationally efficient method utilizing a spherical harmonic expansion is developed to calculate the quasilinear solution of audio sound fields based on both kuznetsov and westervelt equations.The accuracy of using the westervelt equation is examined, and the rigid sphere scattering effects are simulated with the proposed method.It is found the results obtained using the westervelt equation are inaccurate near the sphere at low frequencies.Contrary to conventional loudspeakers, the directivity of the audio sound generated by a pal severely deteriorates behind a sphere, as the ultrasounds maintaining the directivity of the audio sound are almost completely blocked by the sphere.Instead, the ultrasounds are reflected and generate audio sound on the front side of the sphere.It means that a listener in front of the pal will hear the audio sound scattered back after introducing the sphere as if it is reflected by the sphere.The experiment results are also presented to validate the numerical results.

Journal: The Journal of the Acoustical Society of America (2022)
Publication types: Journal Article
Emerging MR methods for improved diagnosis of prostate cancer by multiparametric MRI.

Current challenges of using serum prostate-specific antigen (psa) level-based screening, such as the increased false positive rate, inability to detect clinically significant prostate cancer (pca) with random biopsy, multifocality in pca, and the molecular heterogeneity of pca, can be addressed by integrating advanced multiparametric mr imaging (mp mri) approaches into the diagnostic workup of pca.The standard method for diagnosing pca is a transrectal ultrasonography (trus)-guided systematic prostate biopsy, but it suffers from sampling errors and frequently fails to detect clinically significant pca.Mp mri not only increases the detection of clinically significant pca, but it also helps to reduce unnecessary biopsies because of its high negative predictive value.Furthermore, non-cartesian image acquisition and compressed sensing have resulted in faster mr acquisition with improved signal-to-noise ratio, which can be used in quantitative mri methods such as dynamic contrast-enhanced (dce)-mri.With the growing emphasis on the role of pre-biopsy mp mri in the evaluation of pca, there is an increased demand for innovative mri methods that can improve pca grading, detect clinically significant pca, and biopsy guidance.To meet these demands, in addition to routine t1-weighted, t2-weighted, dce-mri, diffusion mri, and mr spectroscopy, several new mr methods such as restriction spectrum imaging, vascular, extracellular, and restricted diffusion for cytometry in tumors (verdict) method, hybrid multi-dimensional mri, luminal water imaging, and mr fingerprinting have been developed for a better characterization of the disease.Further, with the increasing interest in combining mr data with clinical and genomic data, there is a growing interest in utilizing radiomics and radiogenomics approaches.These big data can also be utilized in the development of computer-aided diagnostic tools, including automatic segmentation and the detection of clinically significant pca using machine learning methods.

Journal: Magma (New York, N.Y.) (2022)
Publication types: Journal Article;Review