syedzayyan/paper_mill_benchmark huggingface dataset:
Serum CTRP9 Reflects Coronary Collateralization in Nondiabetic Patients with Obstructive Coronary Artery Disease.

To explore the association between the serum c1q/tumor necrosis factor-related protein 9 (ctrp9) and the formation of coronary collateral circulation in obstructive coronary artery disease (cad).Methods a total of 206 patients who underwent coronary angiography at beijing anzhen hospital and had epicardial arteries with at least 95% stenotic lesion were enrolled.Blood samples were taken after an overnight fasting before the coronary angiography.Serum ctrp9 level was measured using commercial enzyme linked immunosorbent assay (elisa) kit.The development of coronary collateralization was determined according to the rentrop classification system.Rentrop score 0-1 was graded as impaired or less-developed coronary collateralization (n= 54) while the rentrop score 2-3 was defined as well-developed collateralization (n= 152).Results serum ctrp9 level was significantly higher in well-developed collateralization and diabetes groups (p< 0.001).To further explore the association between the ctrp9 level and coronary collateralization, the enrolled participants were divided into 3 tertiles according to the serum ctrp9 level.The prevalence of impaired coronary collateralization decreased stepwise with the increasing ctrp9 tertiles (pfor trend <0.001).Multivariate regression analysis showed that the serum ctrp9 is independently associated with well-developed collateralization, with an or (95% ci) of 4.49 (1.75-11.55) and 8.98 (2.75-29.35) in the tertiles 2 and 3, respectively.The following subgroup and receiver-operating characteristic (roc) analysis also indicated that the diagnostic value of serum ctrp9 level for detecting the formation of collateralization persisted only in nondiabetic participants.Lastly, adding the serum ctrp9 into the baseline model could increase the diagnostic value of established model consisting of relevant factor for the discrimination of well-developed collateralization only in the nondiabetic group (p= 0.046).Conclusions serum ctrp9 reflects well-developed coronary collateralization in nondiabetic patients with obstructive cad, and ctrp9 level ≥ 1.217 indicated a greater chance to forming well-developed coronary collaterals.

Journal: BioMed research international (2022)
Publication types: Journal Article
Intrinsically Nonswellable Multifunctional Hydrogel with Dynamic Nanoconfinement Networks for Robust Tissue-Adaptable Bioelectronics.

Developing bioelectronics that retains their long-term functionalities in the human body during daily activities is a current critical issue.To accomplish this, robust tissue adaptability and biointerfacing of bioelectronics should be achieved.Hydrogels have emerged as promising materials for bioelectronics that can softly adapt to and interface with tissues.However, hydrogels lack toughness, requisite electrical properties, and fabrication methodologies.Additionally, the water-swellable property of hydrogels weakens their mechanical properties.In this work, an intrinsically nonswellable multifunctional hydrogel exhibiting tissue-like moduli ranging from 10 to 100 k pa, toughness (400-873 j m-3), stretchability (≈1000% strain), and rapid self-healing ability (within 5 min), is developed.The incorporation of carboxyl- and hydroxyl-functionalized carbon nanotubes (f cnts) ensures high conductivity of the hydrogel (≈40 s m-1), which can be maintained and recovered even after stretching or rupture.After a simple chemical modification, the hydrogel shows tissue-adhesive properties (≈50 k pa) against the target tissues.Moreover, the hydrogel can be 3d printed with a high resolution (≈100 μm) through heat treatment owing to its shear-thinning capacity, endowing it with fabrication versatility.The hydrogel is successfully applied to underwater electromyography (emg) detection and ex vivo bladder expansion monitoring, demonstrating its potential for practical bioelectronics.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Age features of buccal epithelium in practically healthy people.

Recently, buccal epithelium has been used to study age-dependent processes.This approach is of particular relevance due to its non-invasiveness.The purpose of this study is to establish the normal values of the buccal cytogram in different age groups, including athletes.200 practically healthy volunteers of different ages were examined, who were divided into 5 groups in accordance with the who age classification.In addition, 125 professional athletes took part in the study.All patients underwent a comprehensive dental examination and a standard cytological examination of buccal smears.It has been established that the cytological characteristics of buccal epitheliocytes, indirectly reflecting disorders of the nuclear apparatus of the cell, did not change significantly with age, but there was a certain upward trend in the number of cells with such anomalies (micronucleus, protrusions).the number of binuclear cells and the apoptotic index also slightly increase with age.At the same time, a high positive correlation was found between the apoptosis index and senile age.In young athletes, an increase in the number of buccal epitheliocytes with a perinuclear vacuole (an early sign of cell damage) was found analysis of the cytological examination results of the buccal epithelium in people a slight increase in the level of cytological abnormalities in old age, in particular, signs of apoptosis.In addition, in healthy young athletes (18 years old - 44 years old), an increase in the number of cells with signs of nuclear degradation, which most likely reflects increased mechanical stress on the maxillofacial apparatus during sports activities.

Journal: Klinicheskaia laboratornaia diagnostika (2022)
Publication types: Journal Article
Sharing psychosocial risk screening information with pediatric oncology healthcare providers: Service utilization and related factors.

Psychosocial morbidity in pediatric oncology patients and their caregivers is widely recognized.Although routine systematic psychosocial screening has been proposed as a standard of care, screening is still limited.The present study assessed whether supplying the patient's treating team of healthcare providers with psychosocial risk screening information near diagnosis would increase the rate of documented psychosocial contacts, particularly for patients/families with elevated risk.The effect of demographic and clinical factors was also examined.Procedures ninety-three families with a child/youth newly diagnosed with cancer participated.Families were randomly assigned to a care as usual control group (n = 44) or an intervention group (n = 49) where the treating team was provided with a summary of family psychosocial risk, measured by the psychosocial assessment tool (pat).The pat was completed by the primary caregiver, who also provided demographic information.The number of psychosocial intervention contacts documented in the medical charts was examined.Results the rate of psychosocial intervention did not significantly differ between the groups (p > 0.05).The intensity of the child's cancer treatment was found to be the only significant predictor of the number of documented psychosocial intervention contacts (β = 0.396, p < 0.001).Conclusions clinical factors appear to be more predictive of the rate of psychosocial intervention provided to pediatric oncology patients and their families than informing the treating team of family psychosocial risk.Additional research is required to address the gap between psychosocial risk screening, psychosocial intervention, and family outcomes.

Journal: Pediatric blood & cancer (2022)
Publication types: Journal Article;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
A Telemonitoring Intervention for Cirrhotic Ascites Management Is Cost-Saving.

Patients with cirrhosis and ascites experience frequent hospital admissions, leading to poor quality of life and high healthcare costs.Monitoring weight is a component of ascites care and telemonitoring may improve outcomes and costs.Goals we aimed to evaluate the cost and outcomes of current care compared to a telemonitoring system for ascites.Study we developed a decision-analytic model that examined 100 simulated patients over a 6-month horizon.We compared usual care to a new telemonitoring program, which we estimate costs $50,000/6 months.Results the cost of standard of care for 100 patients with cirrhotic ascites over a 6-month period is $167,500 more expensive than telemonitoring.By varying parameter probabilities by ± 10% and outcome costs by ± 20%, we found that standard of care remains more expensive than care with a telemonitoring intervention by $9400 to $340,200 per 6-month period.Standard of care leads to 9 more admissions (range 4 to 12) than a telemonitoring intervention, while telemonitoring leads to 9 more outpatient visits (range 6 to 9) and 28 additional outpatient large volume paracenteses (lvps) (range 17 to 28).With more and less expensive telemonitoring interventions, standard of care remained more expensive.With 50% adherence to the intervention, standard of care was $89,848 more expensive.Conclusions in almost all probability and cost scenarios, a telemonitoring intervention is cost-saving for the management of cirrhotic ascites.Using hospital admissions as a surrogate for quality of care, patient outcomes are improved primarily though more proactive medical intervention and more lvps.

Journal: Digestive diseases and sciences (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Expressional regulation of NKG2DLs is associated with the tumor development and shortened overall survival in lung adenocarcinoma.

Natural killer group 2d ligands (nkg2dls) are expressed on tumor cells as a ligand for natural killer group 2d (nkg2d) receptors.Nkg2dls interact with nkg2d to induce immune cell-mediated cytotoxicity for eliminating tumors.Studies demonstrated that tumor cells can reduce nkg2dls' expression to escape from anti-tumor immunity, leading to an aggressive cancer phenotype and poor prognosis in some cancers.However, these studies are limited and there is no comprehensive work on the regulation of nkg2dls in lung adenocarcinoma (luad) which is one of the deadliest cancers worldwide.Here, we conducted an in silico analysis to evaluate the changes in nkg2dls in luad by analyzing the cancer genome atlas and the gene expression omnibus datasets including tumor vs.Normal comparisons, tnm stages, survival and infiltrating immune estimation profile.Results indicated that some members of nkg2dl were downregulated in luad as compared to normal samples.We determined that mica (mhc class i polypeptide-related sequence a) was the most and significantly downregulated ligand among others and the results were nearly consistent with the different datasets which we used.Furthermore, survival analysis revealed that down-regulated mica transcript expression might be one of the prognostic indicators of luad.Interestingly, according to the immune cell infiltrating analysis, there wasn't a direct correlation between the mica transcript expression and immune cell infiltration, while for micb there was.In addition, in genetic alteration, dna methylation and mi rna analyses, we did not observe critical outcomes that would clarify the down-regulated mica expression in detail.Regardless, this study is highly comprehensive and contributes valuable suggestions to further functional studies about the regulation of nkg2dls and promising immunotherapeutic approaches in luad.

Journal: Immunobiology (2022)
Publication types: Journal Article
Straightforward synthesis of quinolines from enones and 2-aminobenzyl alcohols using an iridium-catalyzed transfer hydrogenative strategy.

A new protocol for the direct synthesis of quinolines from enones and 2-aminobenzyl alcohols via iridium-catalyzed transfer hydrogenative reactions has been demonstrated.This method employs easily available [ir cp*cl2]2/t-bu ok as the efficient catalyst system, proceeding with the merits of high step- and atom efficiency, mild reaction conditions and operational simplicity.The experimental studies suggest that the reactions start with transfer hydrogenation, followed by the friedländer reaction to give the final products.

Journal: Organic & biomolecular chemistry (2018)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathway.

Periprosthetic osteolysis (ppo) triggered by wear particles is the most severe complication of total joint replacement (tjr) surgeries, representing the major cause of implant failure, which is public health concern worldwide.Previous studies have confirmed the specialized role of osteoclast-induced progressive bone destruction in the progression of ppo.Additionally, the reactive oxygen species (ros) induced by wear particles can promote excessive osteoclastogenesis and bone resorption.Nicotinamide adenine dinucleotide phosphate oxidase 4 (nox4), a cellular enzyme, is considered to be responsible for the production of ros and the formation of mature osteoclasts.However, nox4 involvement in ppo has not yet been elucidated.Therefore, we investigated the mechanism by which nox4 regulates osteoclast differentiation and the therapeutic effects on titanium nanoparticle-induced bone destruction.We found that nox4 blockade suppressed osteoclastogenesis and enhanced the scavenging of intracellular ros.Our rescue experiment revealed that nuclear factor-erythroid 2-related factor 2 (nrf2) silencing reversed the effects of nox4 blockade on ros production and osteoclast differentiation.In addition, we found increased expression levels of nox4 in ppo tissues, while nox4 inhibition in vivo exerted protective effects on titanium nanoparticle-induced osteolysis through antiosteoclastic and antioxidant effects.Collectively, these findings suggested that nox4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the nrf2 signaling pathway and that nox4 blockade may be an attractive therapeutic approach for preventing ppo.

Journal: Journal of nanobiotechnology (2022)
Publication types: Journal Article
Treatment patterns, effectiveness, and patient-reported outcomes of palbociclib therapy in Chinese patients with advanced breast cancer: A multicenter ambispective real-world study.

Palbociclib was the only available cyclin-dependent kinase 4/6 inhibitor in china until very recently, and its effect has not been systemically evaluated among chinese patients.This study aims to assess the efficacy, safety and patient-reported outcomes (pros) of palbociclib plus endocrine therapy (et) in real-world china.Methods an ambispective cohort study was conducted on patients with advanced hr+her2- breast cancer who received palbociclib between july 2018, and november 2020 and were enrolled from 12 hospitals.Treatment patterns, survival outcomes, and safety events were documented, and pros (european organization for research and treatment of cancer quality of life questionnaire-core 30 items [eortc qlq-c30] and euro qo l 5 dimensions [eq-5d]) were analyzed.The kaplan-meier method was used to visualize and estimate the median progression-free survival (m pfs).Log-rank tests, cox regressions, t tests, and chi-square tests were performed for comparison.Results a total of 190 patients (median follow-up of 18.0 months) were enrolled.Palbociclib was mostly combined with aromatase inhibitors (66.3%), fulvestrant (32.6%), and tamoxifen (1.1%).The m pfs values were 21.0, 14.0, and 7.0 months with palbociclib administered in first- (n = 83), second- (n = 41) and subsequent-line settings (n = 66), respectively.Endocrine sensitivity was significantly associated with patient prognosis (m pfs: 23.0, 12.0, and 6.0 months for endocrine naïve, acquired, and primary resistant patients, respectively, p < 0.01).The outcome was worse for patients who failed to meet the inclusion criteria of paloma-3 than for those who met the criteria (later-line: 6.0 months vs.9.0 months).The most common adverse events (aes) were neutropenia (74.2%; grade 3/4: 30.0%), fatigue (48.4%), anemia (32.6%), and thrombocytopenia (22.1%).Pro data suggested that palbociclib plus et significantly improved cognitive and emotional function, pain symptoms, and overall quality of life.Conclusions palbociclib is effective for front-line use and for treating endocrine-sensitive patients in real-world china and is generally well tolerated.The prevalence of aes in the chinese population is different from that reported in the paloma-2/3 trials.

Journal: Cancer medicine (2022)
Publication types: Multicenter Study;Journal Article;Research Support, Non-U.S. Gov't
Edentulous Space Closure Using a Clear Aligner System After Alveolar Ridge Split Augmentation.

Orthodontic tooth movement in adult edentulous, atrophic posterior mandibular alveolar ridges is a challenging task.In this case report, a young adult woman seeking an aesthetic orthodontic solution, presented with mandibular alveolar ridge atrophy due to a congenitally missing lower incisor.Alveolar ridge splitting technique using piezosurgery for bone augmentation was selected to minimize the risks of orthodontic movement in the atrophic edentulous space.Orthodontic corrections were planned and executed with a clear aligner system.The surgical and orthodontic interventions combined well together, addressing patients' orthodontic concerns, with minimal intervention, least discomfort, and reduced treatment time.

Journal: The Journal of craniofacial surgery (2022)
Publication types: Case Reports;Journal Article
Exploiting Extracellular Vesicles Strategies to Modulate Cell Death and Inflammation in COVID-19.

The coronavirus disease (covid-19) is responsible for more than 5 million deaths worldwide, with respiratory failure being the most common clinical presentation.Covid-19 complications still present a considerable burden on healthcare systems, and signs of the post-covid syndrome are concerns for potential long-term damages.An increasing body of evidence highlights extracellular vesicles' (evs) relevance in modulating inflammation and cell death in the diseases related to these processes.Several types of evs-based investigational new drugs against covid-19 have been approved by the us food and drug administration to initiate a phase i/ii trial under an investigational new drug protocol.Evs can be employed as natural drug delivery nanoparticle-based systems due to their inherent potential in transferring material between cells, their natural origin, and their capability to encapsulate various biological molecules, offering an exciting alternative for administering drugs acting on the cell cycle control.In this context, small-molecule inhibitors of mouse double minute 2 (mdm2) such as nutlin-3 and idasanutlin by promoting p53 survival and its antiviral activity might be helpful to modulate the ifn signalling pathway and reduce the overall pro-inflammatory burden.

Journal: Frontiers in pharmacology (2022)
Publication types: Journal Article
Optimization of mucilage extraction fromXimenia americanaseed using response surface methodology.

Ximenia americanais a wild edible fruit essential for human consumption due to its high nutritional and phytochemical constituents with significant antioxidant activity.The fruit seed has high potential in its mucilage content.The present study aimed at optimization of mucilage extraction from the ethiopian cultivar of ximeina americanafruit seed.The response surface methodology based on a central composite rotatable design was used for the optimization of aqueous extraction of mucilage.The extraction temperature (50-80 °c), time (1.5-4 h), and water-to-seed ratio (20:1-40:1 v/w) were identified as the major factors influencing mucilage yield, water holding capacity, and protein content.Water to seed ratio and time showed significant (p< 0.01) interaction effect on yield.Interactions of water to seed ratio with time and temperature had significant effects (p< 0.05) on the protein content.Water holding capacity of the mucilage was significantly (p< 0.05) affected by the interaction between temperature and time.Optimum extraction processing conditions were obtained to be extraction temperature of 65.06 °c, time of 1.5 h and water to seed ratio of 37.62:1 v/w.The response variables at this operating conditions were found to be extraction yield of 17.31 %, water holding capacity of 11.48 g/g and protein content of 1.75 %.The result demonstrated that the x.Americanaseed mucilage could be used as a new source of additives in the dairy industry as a fat replacer due to its potent water holding capacity.

Journal: Heliyon (2022)
Publication types: Journal Article
The Role of Preemptive Infiltration Anesthesia in the Management of Postoperative Pain Following Septoplasty.

Introduction septoplasty is one of the most common surgical procedures in rhinology practice.Two major problems encountered after septoplasty are pain and bleeding.Preoperative administration of analgesics before the surgical stimulus, which is the main concept of preemptive analgesia, decreases postoperative pain.objective the present study was designed to investigate whether preincisional lidocaine infiltration to the subperichondrial area during septoplasty surgery reduced or not postoperative pain and analgesic use.methods the present prospective, randomized, placebo controlled, double-blind trial was conducted on 64 consecutive patients with nasal septum deviation.Patients were randomly divided into 2 groups; the study group received 2% 20 mg lidocaine/cc (n= 31), and the control group received 6 cc 0.9% na cl (n= 33).A standard questionnaire was given to each patient to mark his or her pain score between 0 and 10 at the 1st, 3rd, 6th, 12th, and 24thhours.results the mean and the range of visual analogue scale (vas) scores of the patients in the study group at the 1st, 3rd, 12th, and 24thhours were 4.03 ± 3.08 (0-10); 3.42 ± 2.39 (0-8); 2.97 ± 2.22 (0-8); 2.87 ± 2.61 (0-9); and 1.94 ± 2.06 (0-9) respectively.The mean and the range of vas scores of the patients in the control group at the 1st, 3rd, 12th, and 24thhours were 4.12 ± 2.7 (0-10); 3.45 ± 2.4 (0-10); 2.94 ± 2.7 (0-10); 2.79 ± 2.34 (0-10); and 1.5 ± 1.8 (0-6), respectively.The statistical analysis revealed no significant difference among the groups.conclusion the preemptive local anesthetic administration to the incision area and under the mucoperichondrial flap before septoplasty does not decrease the level of postoperative pain.

Journal: International archives of otorhinolaryngology (2022)
Publication types: Journal Article
Estimating employment from energy-efficiency investments.

We develop a methodology for estimating the number and types of jobs that would result from investments in energy efficiency in homes, businesses, and industry.The methodology involves the development of input-output (i-o) bills of goods that characterize how energy-efficiency funds would be spent across sectors of the economy.The methodology builds on and adds greater articulation to the research conducted in prior studies of u.s.Energy-efficiency policies.•the first two steps involve estimating the magnitude of investments in energy-efficient technologies and systems required to produce a unit of energy consumption reduction, and then identifying how these investments are expensed across the broad investment categories, which creates the preliminary "bills of goods" for investments in energy efficiency in homes, businesses, and industry.•the third step involves soliciting feedback on the preliminary bills of goods from experts in delivering and evaluating energy-efficiency programs, and then making necessary modifications.•in the final step we apply the input-output coefficients representing the bills of goods to estimate the direct, indirect and induced employment per million dollars of investment in energy efficiency.

Journal: MethodsX (2020)
Publication types: Journal Article