syedzayyan/paper_mill_benchmark huggingface dataset:
Navigating the Path to a Sustainable "PACU Pause" and Standardized Perioperative Handoff: A Quality Improvement Project.

The purpose of this project was to develop and implement a pause and standardized perioperative handoff to improve the quality of the handoff and the satisfaction of the perioperative team in the postanesthesia care unit (pacu) setting.Design the iowa model for evidence-based practice guided this evidence-based practice-quality improvement project.Methods a team was formed of key nurses and other perioperative members to execute the project.The outcome of the evidence review, appraisal, and synthesis supported the change to a pause and standardized perioperative handoff.The project team educated perioperative staff on the practice change and new process.Baseline, 3-month and 1-year data were collected for adherence to the pacu pause and handoff critical elements, and baseline and 3-months for satisfaction.Findings pacu pause adherence was 42.30% prepractice change, 92.3% postchange and 96.10% at 1-year.Adherence to the 17 critical elements in the standardized handoff was 40.16% prepractice change, 77.36% postchange and 71.78% at 1-year.Nurse satisfaction with the pacu pause and handoff increased 59% and 50% respectively from pre to postpractice change.Operating room nurse and anesthesia provider satisfaction with pacu pause and handoffs was greater than 85% at baseline and increased 14% and 8% respectively.Conclusions the pacu pause allows for increased nurse concentration during the handoff and this can improve patient safety.Using a standardized handoff in situation, background, assessment, response format can decrease information loss and miscommunication, improve the quality of the handoff and the perioperative team members satisfaction with the handoff, and may mitigate patient safety events.

Journal: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses (2022)
Publication types: Journal Article
Urate-lowering effect of calcium supplementation: Analyses of a randomized controlled trial.

To investigate if the gout-protective effect of low-fat dairy products could be attributed to the urate-lowering effect of calcium.Methods this is a placebo-controlled trial in which thirty-five adult (aged 18-42 years) female low-calcium consumers (<800 mg/d) were randomized to one of three treatment groups: low calcium breakfast (control, ∼70 mg of calcium/d) -c or high-calcium breakfast (∼770 mg/d) from calcium citrate - cit or from skim milk - sm, during 45 consecutive days.Breakfasts were matched for potential confounders and were provided as part of an energy-restricted normoprotein diet containing an additional 800 mg of calcium/d.Dual-energy x-ray absorptiometry measurements (body fat assessment) and fasting blood samples (urate, ionic calcium, pth, and 1,25-(oh)2-d3) were taken at baseline and the end of the experiment.Clinical trial registration (rbr-7q2n33).Results despite no significant changes in total body weight/fat, cit and sm led to a significant reduction in serum urate and ionic calcium, but did not affect pth and vitamin d concentrations compared to c.Cit and sm reduced baseline serum urate by ∼14% and ∼17%, respectively.There was a trend to a positive correlation between changes in serum urate and changes in ionic calcium on day 45 (r = 0.327, p = 0.055).Conclusions calcium supplementation (770 mg/d from dairy or calcium citrate) reduced serum urate concentrations, suggesting that the gout-protective effect of low-fat dairy consumption is at least partly due to a urate-lowering effect of calcium.

Journal: Clinical nutrition ESPEN (2022)
Publication types: Journal Article;Randomized Controlled Trial;Research Support, U.S. Gov't, Non-P.H.S.
Self-Reported Food Safety Practices and Associated Factors Among Health Extension Model and Non-Model Households in Northeastern Ethiopia: A Comparative Cross-Sectional Study.

Eating contaminated food continues to cause numerous food-borne diseases globally.Understanding the causes of poor food safety practices is key to preventing food-borne diseases.Therefore, this study aimed to assess the prevalence of food safety practices and associated factors among health extension model and non-model households in kombolcha, ethiopia.Methods a comparative cross-sectional study was conducted among 327 model households and 329 non-model households in kombolcha.Four kebeles were selected randomly from a total of 12 kebeles, followed by a systematic random sampling method to select a total of 656 households.The data were collected through face-to-face interviews with household heads and observations from april 15 to may 15, 2021.Data were entered into epi data version 3.1 and analyzed using spss version 25.0.Determinants of food safety practices were determined by using multivariable logistic regression model at ap-value <0.05.Results the overall prevalence of food safety practices was 44.7% (95% ci: 40.5-48.4%), of which 57.8% (95% ci: 53.0-63.1%) were model and 31.6% (95% ci: 26.5-36.7%) were non-model households, with significant variation among household types.Being a model household (aor=2.99; 95% ci: 1.98-4.52), having a female household head (aor=3.13; 95% ci: 2.13-4.59), proper solid waste management (aor=2.32; 95% ci: 1.54-3.48), good knowledge of food safety (aor=2.05; 95% ci: 1.43-3.03), and good attitude (aor=1.74; 95% ci: 1.22, 2.49) were significant predictors of good food safety practices.Conclusion the prevalence of good food safety practices was not satisfactory.Being a model household, having a female household head, proper solid waste management, good knowledge, and good attitude were significantly associated with good food safety practices.Therefore, the identified modifiable factors are potential areas of intervention to enhance good food safety practices.

Journal: Risk management and healthcare policy (2022)
Publication types: Journal Article
Incorporation of complementary and traditional medicine in ICD-11.

Traditional medicine (tm) is practiced in various forms in over 180 countries.Despite this, health information systems on tm are limited.Consistent with this, the world health organization's (who) international classification for diseases (icd) has not to date included tm concepts.This is now changing, as the who has endorsed the reflection of tm paradigms in the new 11th revision of icd (icd-11).Although some countries have had national traditional medicine classification systems for many years, information from such systems has not been standardized nor been made available globally.By including tm within the icd, international standardization will be possible allowing for measuring, counting, comparing, formulating questions and monitoring over time.Icd-11 is a classification system for the twenty-first century, and it now provides an opportunity for interested users to integrate the coding of diagnostic concepts from both tm and western medicine.This paper describes the new tm classification in icd and demonstrates through coding examples how to code tm concepts alongside western medicine concepts.

Journal: BMC medical informatics and decision making (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Clinical characteristics, multiorgan dysfunction and outcomes of patients with COVID-19: a prospective case series.

Characterizing the multiorgan manifestations and outcomes of patients hospitalized with covid-19 will inform resource requirements to address the long-term burden of this disease.We conducted a descriptive analysis using prospectively collected data to describe the clinical characteristics and spectrum of organ dysfunction, and in-hospital and longer-term clinical outcomes of patients hospitalized with covid-19 during the first wave of the pandemic at a canadian centre.Methods we conducted a prospective case series involving adult patients (aged ≥ 18 yr) with covid-19 admitted to 1 of 2 hospitals in london, ontario, from mar.17 to june 18, 2020, during the first wave of the pandemic.We recorded patients' baseline characteristics, physiologic parameters, measures of organ function and therapies administered during hospitalization among patients in the intensive care unit (icu) and in non-icu settings, and compared the characteristics of hospital survivors and nonsurvivors.Finally, we recorded follow-up thoracic computed tomography (ct) and echocardiographic findings after hospital discharge.Results we enrolled 100 consecutive patients (47 women) hospitalized with covid-19, including 32 patients who received icu care and 68 who received treatment in non-icu settings.Respiratory sequelae were common: 23.0% received high-flow oxygen by nasal cannula, 9.0% received noninvasive ventilation, 24.0% received invasive mechanical ventilation and 2.0% received venovenous extracorporeal membrane oxygenation.Overall, 9.0% of patients had cerebrovascular events (3.0% ischemic stroke, 6.0% intracranial hemorrhage), and 6.0% had pulmonary embolism.After discharge, 11 of 19 patients had persistent abnormalities on ct thorax, and 6 of 15 had persistent cardiac dysfunction on echocardiography.Interpretation this study provides further evidence that covid-19 is a multisystem disease involving neurologic, cardiac and thrombotic dysfunction, without evidence of hepatic dysfunction.Patients have persistent organ dysfunction after hospital discharge, underscoring the need for research on long-term outcomes of covid-19 survivors.

Journal: CMAJ open (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Discovery and initial characterization of YloC, a novel endoribonuclease inBacillus subtilis.

The bacillus subtilisgenome is predicted to encode numerous ribonucleases, including four 3' exoribonucleases that have been characterized to some extent.A strain containing gene knockouts of all four known 3' exoribonucleases is viable, suggesting that one or more additional rnases remain to be discovered.A protein extract from the quadruple rnase mutant strain was fractionated and rnase activity was followed, resulting in the identification of an enzyme activity catalyzed by the ylo c protein.Ylo c is an endoribonuclease and is a member of the highly conserved "yic c family" of proteins that is widespread in bacteria.Ylo c is a metal-dependent enzyme that catalyzes the cleavage of single-stranded rna, preferentially at u residues, and exists in an oligomeric form, most likely a hexamer.As such, ylo c shares some characteristics with the sars-co v nsp15 endoribonuclease.While the in vivo function of ylo c in b.Subtilisis yet to be determined, ylo c was found to act similarly to yic c in an escherichia coliin vivo assay that assesses decay of the small rna, ryh b.Thus, ylo c may play a role in small rna regulation.

Journal: RNA (New York, N.Y.) (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, N.I.H., Intramural
IL-5 mediates monocyte phenotype and pain outcomes in fibromyalgia.

Fibromyalgia (fm) is characterized by widespread chronic pain, fatigue, and somatic symptoms.The influence of phenotypic changes in monocytes on symptoms associated with fm is not fully understood.The primary aim of this study was to take a comprehensive whole-body to molecular approach in characterizing relationships between monocyte phenotype and fm symptoms in relevant clinical populations.Lipopolysaccharide-evoked and spontaneous secretion of il-5 and other select cytokines from circulating monocytes was higher in women with fm compared to women without pain.In addition, greater secretion of il-5 was significantly associated with pain and other clinically relevant psychological and somatic symptoms of fm.Furthermore, higher levels of pain and pain-related symptoms were associated with a lower percentage of intermediate monocytes (cd14++/cd16+) and a greater percentage of nonclassical monocytes (cd14+/cd16++) in women with fm.Based on findings from individuals with fm, we examined the role of il-5, an atypical cytokine secreted from monocytes, in an animal model of widespread muscle pain.Results from the animal model show that il-5 produces analgesia and polarizes monocytes toward an anti-inflammatory phenotype (cd206+).Taken together, our data suggest that monocyte phenotype and their cytokine profiles are associated with pain-related symptoms in individuals with fm.Furthermore, our data show that il-5 has a potential role in analgesia in an animal model of fm.Thus, targeting anti-inflammatory cytokines such as il-5 secreted by circulating leukocytes could serve as a promising intervention to control pain and other somatic symptoms associated with fm.

Journal: Pain (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Cystathionine β-synthase regulates mitochondrial morphogenesis in ovarian cancer.

Deregulation of mitochondrial morphogenesis, a dynamic equilibrium between mitochondrial fusion and fission processes, is now evolving as a key metabolic event that fuels tumor growth and therapy resistance.However, fundamental knowledge underpinning how cancer cells reprogram mitochondrial morphogenesis remains incomplete.Here, we report that cystathionine β-synthase (cbs) reprograms mitochondrial morphogenesis in ovarian cancer (ov ca) cells by selectively regulating the stability of mitofusin 2 (mfn2).Clinically, high expression of both cbs and mfn2 implicates poor overall survival of ov ca patients, and a significant association between cbs and mfn2 expression exists in individual patients in the same data set.The silencing of cbs by small interfering rna or inhibition of its catalytic activity by a small molecule inhibitor creates oxidative stress that activates jnk.Activated jnk phosphorylates mfn2 to recruit homologous to the e6-ap carboxyl terminus' domain-containing ubiquitin e3 ligase for its degradation via the ubiquitin-proteasome system.Supplementation with hydrogen sulfide or glutathione (the catalytic products of cbs enzymatic activity), anti-oxidants, or a jnk inhibitor restores mfn2 expression.In cbs-silenced orthotopic xenograft tumor tissues, mfn2 but not mfn1 is selectively downregulated.In summary, this report reveals a role for deregulated mitochondrial morphogenesis in ov ca, suggests one of the mechanisms for this deregulation, and provides a way to correct it through modulation of the metabolic enzyme cbs.-chakraborty, p.K., murphy, b., mustafi, s.B., dey, a., xiong, x., rao, g., naz, s., zhang, m., yang, d., dhanasekaran, d.N., bhattacharya, r., mukherjee, p.Cystathionine β-synthase regulates mitochondrial morphogenesis in ovarian cancer.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2018)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
A first-principles study of the ultra-high spin rectification effect based on nitride MXenes (Sc2NO2, Ti2NO2).

Nitride mxenes exhibit inherent strong chemical stability and ferromagnetic properties, which are significant for their application in nanoscale spintronic devices.To demonstrate the potential of nitride mxenes in spintronics, we have designed a sc2no2/ti2no2heterojunction and investigated its spin transport properties using first principles calculations combined with the non-equilibrium green's function.The results show that the sc2no2/ti2no2heterojunction has a stable negative differential resistance effect and a great spin rectification effect with a rectification ratio of 1.73 × 1011.The corresponding energy band structures and the transport behavior establish the mechanism for such properties.In addition, the perfect two-dimensional morphology provides a suitable nanostructured material for developing spintronic devices.

Journal: Physical chemistry chemical physics : PCCP (2022)
Publication types: Journal Article
Brachial Plexus' Schwannoma in a Child.

Children's schwannoma is a rare condition, generally occurring in a sporadic way.Its aetiology is still not fully understood.We report the case of a 10-year old girl who presented a left shoulder mass, along motility reduction of the left upper limb for 24 months before presentation at our service.A biopsy resection of the mass gave the diagnosis and 6 months after surgical resection, no complication occurred.

Journal: African journal of paediatric surgery : AJPS (2022)
Publication types: Case Reports;Journal Article
"When that understanding is there, you work much better together": the role of family in audiological rehabilitation for older adults.

This study aimed to explore the experiences and perceptions of adults with hearing impairment and family members regarding the role of family in audiological rehabilitation.Design a qualitative descriptive methodology was used.Study sample a total of 37 people participated, 24 older adults with hearing impairment and 13 family members (11 spouses and 2 adult children).Four focus group interviews were conducted with the adults with hearing impairment, and 3 with family members.Results five key themes emerged from analysis of the transcripts: (1) knowledge and understanding of hearing impairment and treatment; (2) the role of family members in rehabilitation is complex and multifaceted; (3) audiologists have an influential role in facilitating family member involvement; (4) the role of communication in rehabilitation; and (5) outcomes of family member involvement.Importantly, although perceptions were generally very positive, there was some uncertainty about the role of family.Conclusions audiologists have a key role in facilitating family involvement in audiological rehabilitation that is identified by adults with hearing impairment and their families.Although participants reported limited involvement in audiological rehabilitation currently, they identified potential for involvement in areas such as goal setting and decision-making.

Journal: International journal of audiology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Divergent Patterns in Care Utilization and Financial Distress between Patients with Blood Cancers and Solid Tumors: A National Health Interview Survey Study, 2014-2020.

Introduction: important differences exist between the presentation, treatment, and survivorship of patients and survivors with blood cancers.Furthermore, existing research in financial toxicity has not fully addressed the relationship between medical care utilization and patient-reported outcomes of financial barriers and distress.We answered these questions by using a nationally representative survey.Methods: respondents with blood cancers and solid tumors from the national health interview survey were identified (2014−2020).We identified 23 survey questions as study outcomes and grouped them into three domains of medical care utilization, financial barriers to care, and financial distress.Associations between the three domains and associations of study outcomes between cancer types were examined using weighted univariate analyses and multivariable linear and logistic regressions.Results: the final study group consisted of 6248 respondents with solid tumors and 398 with blood cancers (diagnosed ≤ 5 years).Across all respondents with cancer, higher medical care utilization is generally associated with increased financial barriers to care.Compared to respondents with solid tumors, respondents with blood cancers had a higher level of medical care utilization (β = 0.36, p = 0.02), a lower level of financial barriers to care (β = −0.19, p < 0.0001), and a higher level of financial distress in affording care (β = 0.64, p = 0.03).Conclusions: patients and survivors with blood cancers and solid tumors demonstrate divergent patterns in care utilization, financial barriers, and financial distress.Future research and interventions on financial toxicity should be tailored for individual cancer groups, recognizing the differences in medical care utilization, which affect the experienced financial barriers.

Journal: Cancers (2022)
Publication types: Journal Article
Weight loss with glucagon-like peptide-1 receptor agonists in Bardet-Biedl syndrome.

Bardet-biedl syndrome (bbs) is a rare genetic condition, characterized by ciliary protein dysfunction, leading to multi-organ damage.People with bbs can develop early-onset severe obesity and associated problems including the metabolic syndrome, type 2 diabetes and coronary heart disease.Weight management can be challenging with the lack of effective medical therapies so far.We report a patient with bbs who underwent successful weight reduction through the use of glucagon-like peptide-1 receptor agonists.

Journal: Clinical obesity (2022)
Publication types: Case Reports;Journal Article
Metabolic syndrome after Roux-en-Y gastric bypass in patients with morbid obesity: Five years of follow-up, a before and after study.

Metabolic syndrome (met s) is common among morbidly obese patients undergoing bariatric surgery.The aim of this study is to analyse prevalence and evolution of met s in patients suffering from morbid obesity, before and after bariatric surgery, during a follow-up period of 5 years.Methods a before-after study was carried out including 156 patients with met s.The definition of metabolic syndrome according to the joint interim statement (jis) definition was used.Demographic, as well as anthropometric, biochemical, and clinical analyses were assessed before, as well as 2 and 5 years after performing laparoscopic roux-en-y gastric bypass (rygb).Results high bmi (100%), elevated blood pressure (78%) and low levels of high density lipoprotein (70%) were the most prevalent criteria for met s.The percentage of people with met s decreased significantly to 48.9% at 2 years and 24.1% at 5 years.The weight was also significantly reduced at 2 years, although at 5 years a rebound effect is already observed.Percentage of total weight loss (%twl) and excess bmi loss (%ebmil) were.49.7 ± 19.4% and 68.2 ± 18.9%, respectively, at 2 years and 29.3 ± 11.6% and 62.0 ± 24.9 at 5 years, both presenting significant differences (p < 0.001).Conclusion rygb in obese patients is associated with a significant improvement of met s and its comorbidities.Insufficient weight loss is the main factor related to the prevalence of met s.

Journal: International journal of surgery (London, England) (2020)
Publication types: Journal Article