syedzayyan/paper_mill_benchmark huggingface dataset:
Relationship between endocrine disruptors and obesity with a focus on bisphenol A: a narrative review.

Introduction:scientific data suggest that early exposure to endocrine-disrupting chemicals (edcs) affect -repro, -neuro, -metabolic systems, to which are added other notions such as mixtures, window and duration of exposure, trans-generational effects, and epigenetic mechanisms.methods:in the present narrative review, we studied the relationship between exposure to edcs with the appearance and development of obesity.results:exposure to edcs like bisphenol a during the early stages of development has been shown to lead to weight gain and obesity.Edcs can interfere with endocrine signaling, affect adipocytes differentiation and endocrine function and disrupt metabolic processes, especially if exposure occurs at very low doses, in the mixture, during early development stages for several generations.conclusion:exposure to edcs is positively associated with obesity development.Moreover, the use of integrative approaches which mimicking environmental conditions are necessary and recommended to evaluate edcs' effects in future studies.

Journal: BioImpacts : BI (2021)
Publication types: Journal Article;Review
Mentoring Underrepresented Students in Speech-Language Pathology: Effects of Didactic Training, Leadership Development, and Research Engagement.

The purpose of this study was to implement and track the outcomes of a yearlong, structured mentoring program aimed at enhancing the retention and success of underrepresented graduate and undergraduate students in speech-language pathology.Method student participants were recruited following an open application process and based on meeting eligibility requirements and committing to program completion.The focus of this program was to provide didactic training on leadership development, culturally responsive practice, and research methods used in speech-language pathology.This program emphasized participant needs assessments and goal-setting, access to one-on-one and group mentoring by peers and professionals, and a culminating experience in which participant teams completed a supervised clinical research project or a community outreach and education project.Results forty-six participants in three cohorts completed the yearlong program in three consecutive years.Positive outcomes included program completion, degree completion, student perceptions of program benefit, completion of innovative community-engaged and research projects, and dissemination of scholarly work.Conclusion our findings from implementing this program and tracking its outcomes have implications for using innovative, equity-minded, and evidence-based strategies for retaining and mentoring minoritized students in speech-language pathology.

Journal: American journal of speech-language pathology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Outbreak of vibriosis associated with Vibrio parahaemolyticus in the mud crab Scylla paramamosain cultured in China.

In this study, a gram-negative bacterium was isolated from diseased scylla paramamosain and tentatively named strain qx17.The bacterial isolate was identified as vibrio parahaemolyticus based on morphological and biochemical characteristics and molecular identification with the 16s r rna and hsp60 genes.In the challenge experiment, s.Paramamosain injected intramuscularly with the v.Parahaemolyticus isolate developed pathological signs similar to the naturally diseased mud crabs.The infection experiment also showed that the median lethal dosage (ld50) for qx17 was 4.79 × 102 cfu g-1 (crab weight).Histopathological analysis of the diseased mud crabs infected with v.Parahaemolyticus showed deformation and basement membrane rupture of hepatopancreatic tubules in the hepatopancreas, and disordered and broken muscle fiber in the muscle.Antimicrobial susceptibility tests revealed that qx17 was highly sensitive to most of the tested aminoglycosides, tetracyclines, and quinolones.To the best of our knowledge, this is the first study reporting isolation and antibiotic sensitivities of v.Parahaemolyticus from cultured mud crabs.The discovery of v.Parahaemolyticus in cultured mud crabs not only adds to the growing list of emerging pathogens in crab aquaculture in china, but also highlights the necessity of developing early detection strategies and appropriate interventions to reduce the damage caused by v.Parahaemolyticus in mud crab aquaculture.

Journal: Diseases of aquatic organisms (2021)
Publication types: Journal Article
Stimuli for Adaptations in Muscle Length and the Length Range of Active Force Exertion-A Narrative Review.

Treatment strategies and training regimens, which induce longitudinal muscle growth and increase the muscles' length range of active force exertion, are important to improve muscle function and to reduce muscle strain injuries in clinical populations and in athletes with limited muscle extensibility.Animal studies have shown several specific loading strategies resulting in longitudinal muscle fiber growth by addition of sarcomeres in series.Currently, such strategies are also applied to humans in order to induce similar adaptations.However, there is no clear scientific evidence that specific strategies result in longitudinal growth of human muscles.Therefore, the question remains what triggers longitudinal muscle growth in humans.The aim of this review was to identify strategies that induce longitudinal human muscle growth.For this purpose, literature was reviewed and summarized with regard to the following topics: (1) key determinants of typical muscle length and the length range of active force exertion; (2) information on typical muscle growth and the effects of mechanical loading on growth and adaptation of muscle and tendinous tissues in healthy animals and humans; (3) the current knowledge and research gaps on the regulation of longitudinal muscle growth; and (4) potential strategies to induce longitudinal muscle growth.The following potential strategies and important aspects that may positively affect longitudinal muscle growth were deduced: (1) muscle length at which the loading is performed seems to be decisive, i.e., greater elongations after active or passive mechanical loading at long muscle length are expected; (2) concentric, isometric and eccentric exercises may induce longitudinal muscle growth by stimulating different muscular adaptations (i.e., increases in fiber cross-sectional area and/or fiber length).Mechanical loading intensity also plays an important role.All three training strategies may increase tendon stiffness, but whether and how these changes may influence muscle growth remains to be elucidated.(3) the approach to combine stretching with activation seems promising (e.g., static stretching and electrical stimulation, loaded inter-set stretching) and warrants further research.Finally, our work shows the need for detailed investigation of the mechanisms of growth of pennate muscles, as those may longitudinally grow by both trophy and addition of sarcomeres in series.

Journal: Frontiers in physiology (2021)
Publication types: Journal Article;Review
In vivo detection of tumor boundary using ultrahigh-resolution optical coherence angiography and fluorescence imaging.

Accurate detection of early tumor margin is of great preclinical and clinical implications for predicting the survival rate of subjects and assessing the response of tumor microenvironment to chemotherapy or radiation therapy.Here, we report a multimodality optical imaging study on in vivo detection of tumor boundary by analyzing neoangiogenesis of tumor microenvironment (microangiography), microcirculatory blood flow (optical doppler tomography) and tumor proliferation (green fluorescent protein [gfp] fluorescence).Microangiography demonstrates superior sensitivity (77.7 ± 6.4%) and specificity (98.2 ± 1.7%) over other imaging technologies (eg, optical coherence tomography) for tumor margin detection.Additionally, we report longitudinal in vivo imaging of tumor progression and show that the abrupt tumor cell proliferation did not occur until local capillary density and cerebral blood flow reached their peak approximately 2 weeks after tumor implantation.The unique capability of longitudinal multimodality imaging of tumor angiogenesis may provide new insights in tumor biology and in vivo assessment of the treatment effects on anti-angiogenesis therapy for brain cancer.

Journal: Journal of biophotonics (2020)
Publication types: Journal Article;Research Support, N.I.H., Extramural
Loss to Follow-Up in Patients with Proliferative Diabetic Retinopathy after Panretinal Photocoagulation or Intravitreal Anti-VEGF Injections.

Loss to follow-up (ltfu) may contribute to vision loss in patients with active proliferative diabetic retinopathy (pdr).The aim of this study is to determine and compare the rates of ltfu in patients with pdr receiving panretinal photocoagulation (prp) or intravitreal injections (ivis) with anti-vascular endothelial growth factor (vegf) over approximately 4 years.Moreover, this study evaluates various risk factors for ltfu.Design retrospective cohort study.Participants a total of 2302 patients with pdr receiving ivis with anti-vegf or prp between january 1, 2012, and april 20, 2016.Methods intervals between each procedure and the subsequent follow-up visit were measured.Loss to follow-up was defined as at least 1 interval exceeding 12 months duration.Main outcome measures the ltfu rates and associated risk factors.Results a total of 1718 patients (74.6%) followed up postprocedure and 584 patients (25.4%) were ltfu over approximately 4 years.Of the patients receiving prp, 28.0% were ltfu compared with 22.1% of patients receiving ivi with anti-vegf (p = 0.001).The ltfu rates decreased as age increased, with rates of 28.1% for patients aged ≤55 years, 27.0% for patients aged 56 to 65 years, and 20.9% for patients aged >65 years (p = 0.002).Loss to follow-up also differed by race, with rates of 19.4% for whites, 30.2% for african americans, 19.7% for asians, 38.0% for hispanics, native americans, and pacific islanders, and 34.9% for patients of unreported race (p $80 000 (p < 0.001).Procedure type, age, race, and regional average agi were all significant (p < 0.05) independent risk factors of ltfu in the multivariate regression.Conclusions a large proportion of patients with pdr were ltfu after receiving prp or an anti-vegf injection over approximately 4 years.Key risk factors included age, race, and regional average agi.

Journal: Ophthalmology (2018)
Publication types: Journal Article
Fragile X Syndrome Secondary to in Vitro Fertilization With a Family Egg Donor: A Case Report and Review of the Literature.

To evidence the need for screening fragile x syndrome (fxs) in egg donors in assisted reproduction protocols.case report:this is the report of a boy with fxs who inherited the mutated allele from an ovule donated by the mother ́s sister through an assisted reproduction protocol.Identifying premutation (pm) carriers of fxs amongst gamete donors isn't part of the obligatory genetic analysis for donors and is only considered by most of the in vitro fertility societies and guidelines as part of the extension screening tests.conclusion:it is cost-effective to do pre-conceptional screening for the pm or full mutation (fm) of the fmr1gene affected in fxs in every woman undergoing assisted reproductive methods, including gamete donors even without a positive family history of intellectual disabilities.This case supports the need of rethinking the guidelines on the necessary gamete donor screening tests in assisted reproduction protocols.

Journal: Journal of family & reproductive health (2021)
Publication types: Case Reports;Journal Article
Potential deleterious effects of paracetamol dose regime used in Nigeria versus that of the United States of America.

Paracetamol, also known as acetaminophen (n-acetyl-para-aminophenol, apap) is the world's most used over-the-counter analgesic-antipyretic drug.Despite its good safety profile, acetaminophen can cause severe hepatotoxicity in overdose, and poisoning from paracetamol has become a major public health concern.Paracetamol is now the major cause of acute liver failure in the united states and europe.This systematic review aims at examining the likelihood of paracetamol use in nigeria causing more liver toxicity vis-à-vis the reduced maximum recommended daily adult dose of 3 g for the 500 mg tablet.Online searches were conducted in the databases of pub med, google scholar and medline for publications using terms like "paracetamol toxicity," "acetaminophen and liver toxicity," "paracetamol and liver diseases in nigeria," and other variants.Further search of related references in pub med was carried out, and synthesis of all studies included in this review finalized.There were 94 studies that met the inclusion criteria.Evaluation of hepatic disorder was predicated mostly on a constellation of clinical features and limited clinical laboratory investigations.Determination of blood paracetamol concentration was rarely reported, thus excluding paracetamol poisoning as one of the likely causes of liver disorders in nigeria.In nigeria and elsewhere, several factors are known to increase paracetamol's predisposition to liver injury.They include: the over-the-counter status of paracetamol, use of fixed-dose combinations of paracetamol with other drugs, malnutrition, dose miscalculations, and chronic alcohol consumption.The tendency to exceed the new paracetamol maximum daily dose of 3 g in nigeria may increase its risk for hepatotoxicity than observed in the united states of america known for emphasizing lower dose of the drug.In addition to recommending the new maximal daily paracetamol dose allowance, the historical maximum daily adult dose of 4 g should be de-emphasized in nigeria.

Journal: Toxicology reports (2022)
Publication types: Journal Article;Review
First-in-human phase 1/1b study to evaluate sitravatinib in patients with advanced solid tumors.

Sitravatinib (mgcd516), a spectrum-selective receptor tyrosine kinase inhibitor targeting tam (tyro3, axl, mertk) and split kinase family receptors, has demonstrated preclinical anti-tumor activity and modulation of tumor microenvironment.This first-in-human phase 1/1b study included sitravatinib dose exploration and anti-tumor activity evaluation in selected patients with advanced solid tumors.Primary objectives included assessment of safety, pharmacokinetics and clinical activity of sitravatinib.Secondary objectives included identifying doses for further investigation and exploring molecular markers for patient selection.In phase 1, 32 patients received 10-200 mg, while phase 1b dose expansion comprised 161 patients (150 mg n = 99, 120 mg n = 62).Maximum tolerated dose was determined as 150 mg daily.Dose-limiting toxicity was reported in 4/28 evaluable phase 1 patients (three at 200 mg, one at 80 mg).In phase 1b, 120 mg was defined as the recommended dose due to tolerability.Treatment-related adverse events (traes) were experienced by 174/193 patients (90.2%); grade ≥ 3 traes in 103 patients (53.4%).Most common traes were diarrhea, fatigue, hypertension and nausea; traes led to treatment discontinuation in 26 patients (13.5%) and death in one patient.Sitravatinib was steadily absorbed and declined from plasma with a terminal elimination half-life of 42.1-51.5 h following oral administration.Overall objective response rate was 11.8% in phase 1b, 13.2% in patients with non-small cell lung cancer (nsclc) and 4.2% in patients with nsclc with prior checkpoint inhibitor experience.Sitravatinib demonstrated manageable safety and modest clinical activity in solid tumors.Nct02219711 (first posted august 14, 2014).

Journal: Investigational new drugs (2022)
Publication types: Clinical Trial, Phase I;Journal Article;Research Support, Non-U.S. Gov't
Identification of uveitis-associated functions based on the feature selection analysis of gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment scores.

Uveitis is a typical type of eye inflammation affecting the middle layer of eye (i.e., uvea layer) and can lead to blindness in middle-aged and young people.Therefore, a comprehensive study determining the disease susceptibility and the underlying mechanisms for uveitis initiation and progression is urgently needed for the development of effective treatments.In the present study, 108 uveitis-related genes are collected on the basis of literature mining, and 17,560 other human genes are collected from the ensembl database, which are treated as non-uveitis genes.Uveitis- and non-uveitis-related genes are then encoded by gene ontology (go) and kyoto encyclopedia of genes and genomes (kegg) enrichment scores based on the genes and their neighbors in string, resulting in 20,681 go term features and 297 kegg pathway features.Subsequently, we identify functions and biological processes that can distinguish uveitis-related genes from other human genes by using an integrated feature selection method, which incorporate feature filtering method (boruta) and four feature importance assessment methods (i.e., lasso, light gbm, mcfs, and m rmr).Some essential go terms and kegg pathways related to uveitis, such as go:0001841 (neural tube formation), has04612 (antigen processing and presentation in human beings), and go:0043379 (memory t cell differentiation), are identified.The plausibility of the association of mined functional features with uveitis is verified on the basis of the literature.Overall, several advanced machine learning methods are used in the current study to uncover specific functions of uveitis and provide a theoretical foundation for the clinical treatment of uveitis.

Journal: Frontiers in molecular neuroscience (2022)
Publication types: Journal Article
The complete mitochondrial genome ofTuberolachnus salignus(Gmelin, 1790) (Hemiptera: Aphididae: Lachninae).

We sequenced the complete mitochondrial genome of tuberolachnus salignuswith a length of 16,868 bp, including 13 protein-coding genes, 22 t rna genes, 2 r rna genes, a control region located betweenrrn sandtrn i, and a repeat region located betweentrn s2andtrn f.All protein-coding genes are initiated with atn and terminated with taa, except thecox1,nad3andnad4with termination of t.The length of the repeat region is 1,407 bp, which repeats 4.04 times with a 305-bp unit.Our phylogenetic analysis showed t.Salignusis sister to stomaphis sinisalicis.

Journal: Mitochondrial DNA. Part B, Resources (2022)
Publication types: Journal Article
Intravescical instillation of Calmette-Guérin bacillus and COVID-19 risk.

It has been theorized that calmette-guérin bacillus may prevent or reduce the severity of covid-19 through a nonspecific stimulation of the immune system.A preliminary assessment of sars-co v-2 infection rates and outcomes among 2803 individuals affected with high risk non-muscle-invasive bladder cancer and treated with intra-bladder instillation of bcg, showed no evidence of a protective effect.However, the interpretation of these data need some caution, due to the low prevalence of infection (<1%) observed within this population, along with the fact that intra-bladder administration cannot mirror the usual intradermal administration of bcg, in particular in patients partially immunocompromised.Confirmation by larger prospective studies is required.

Journal: Human vaccines & immunotherapeutics (2021)
Publication types: Journal Article
Forensic transcriptome analysis using massively parallel sequencing.

The application of transcriptome analyses in forensic genetics has experienced tremendous growth and development in the past decade.The earliest studies and main applications were body fluid and tissue identification, using targeted rna transcripts and a reverse transcription endpoint pcr method.A number of markers have been identified for the forensically most relevant body fluids and tissues and the method has been successfully used in casework.The introduction of massively parallel sequencing (mps) opened up new perspectives and opportunities to advance the field.Contrary to genomic dna where two copies of an autosomal dna segment are present in a cell, abundant rna species are expressed in high copy numbers.Even whole transcriptome sequencing (rna-seq) of forensically relevant body fluids and of postmortem material was shown to be possible.This review gives an overview on forensic transcriptome analyses and applications.The methods cover whole transcriptome as well as targeted mps approaches.High resolution forensic transcriptome analyses using mps are being applied to body fluid/ tissue identification, determination of the age of stains and the age of the donor, the estimation of the post-mortem interval and to post mortem death investigations.

Journal: Forensic science international. Genetics (2021)
Publication types: Journal Article;Review
Cross-cultural adaptation and validation of the Kerlan-Jobe orthopedic clinic shoulder and elbow score for German-speaking overhead athletes.

The kerlan-jobe orthopedic clinic shoulder and elbow score (kjoc) originally developed in english, assesses the functional status of the shoulder and elbow in overhead athletes.To date, no german version of the questionnaire exists.Objective the aim of the study was to translate and to culturally adapt the kjoc into german (kjoc-g) and to test its psychometric properties.Methods the first part of the study consisted of a translation and cross-cultural adaptation process which was performed in six stages according to international recommendations: initial translations, synthesis, back translations, expert committee review, pretesting of the prefinal version, and final adaptations.Secondly, reliability, validity, and feasibility of the kjoc-g were assessed in german overhead athletes.Results the translation and adaptation process led to minor alterations due to cultural differences while maintaining the general structure and content of the original score.A total of 152 overhead athletes (age 25.0 ± 6.6 years; 87 men/65 women) were included in the main analyses.The internal consistency (cronbach's alpha = 0.93) and test-retest reliability (icc2.1= 0.94) of the overall questionnaire were excellent.Moderate correlations with the german version of the disabilities of the arm, shoulder and hand (dash) questionnaire (r = -0.51,p< .05) as well as the dash-sports module (r = -0.54,p< .05) suggest moderate construct validity.Known-group method analysis showed the ability of the kjoc-g to discriminate between actively playing symptomatic (score: 71.2 ± 16.0) and asymptomatic (score: 93.1 ± 8.7) athletes.Conclusion the kjoc-g score is valid, reliable, and suitable for assessing the functional shoulder and elbow status in german-speaking overhead athletes.

Journal: Physiotherapy theory and practice (2022)
Publication types: Journal Article
Current and Future Burden of Hip and Vertebral Fractures in Asia.

The increase in the incidence of hip fractures over time disappeared in northern european and north american caucasians after 2000, while an increase was observed in asian countries including japan until 2010.However, a decrease in the incidence was observed after 2010.The prevalence of vertebral fractures in asians, europeans, and american caucasians is similar, and the incidences of clinical and morphometric vertebral fractures are higher in asians compared with european caucasians.The decrease in the incidence of vertebral fractures over time has been observed in japan.Although the stabilization or decrease over time in the incidence of hip and vertebral fractures have been observed, the number of patients with these fractures is expected to increase rapidly with increases in the elderly population.Multidisciplinary measures to prevent fragility fractures are an urgent issue in asia at this time.This narrative review outlines the recent trends in incidence and future burdens of hip fracture and vertebral fracture in asia.

Journal: Yonago acta medica (2021)
Publication types: Journal Article;Review