syedzayyan/paper_mill_benchmark huggingface dataset:
Long-term sick leave for back pain, exposure to physical workload and psychosocial factors at work, and risk of disability and early-age retirement among aged Swedish workers.

To assess the risk of disability and early-age retirement associated with previous long-term sickness absence for back pain (back-pain sa), exposure to high physical workload, low job control, high demands and high strain, and to evaluate effect modification by work factors on the relationship between back-pain sa and premature retirement.Methods all employed swedish residents born 1946-1955 (n = 835,956) were followed up from 2010 to 2016 for disability (dp) and early-age pension (eap).Associations of premature retirement with exposure to work factors and back-pain sa in the 3 years before follow-up were estimated through proportional hazards models.Retirement, back-pain sa and covariates were assessed through administrative sources, and exposure to work factors through a job-exposure matrix.Results in both genders, back-pain sa was associated with dp (> 1 episode: hr 3.23 among men; hr 3.12 among women) and eap (> 1 episode: hr 1.24 among men; hr 1.18 among women).Higher physical workload and lower job control were also associated with an increased dp risk in both genders, whereas higher job demands showed a decreased risk.For eap, associations with work factors were weak and inconsistent across genders.No effect modification by work factors was found, except for a negative effect modification by job strain on dp risk among women, i.e.A reduced effect of back-pain sa with increasing exposure.Conclusion back-pain sa was a significant predictor of both dp and eap, while work factors were consistently associated only with dp.Our results indicate that the joint effect of back-pain sa and work factors on dp is additive and does not support effect modification by work factors.

Journal: International archives of occupational and environmental health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Portal Vein Embolization: History and Current Indications.

Portal vein embolization (pve) was first adapted for patients undergoing major hepatectomy for hepatocellular carcinoma (hcc).In these patients, pve caused hypertrophy of the unaffected liver and increased the volumetric ratio of future liver remnant (flr) to total liver volume.99m technetium-galactosyl human serum albumin (99m tc-gsa) scintigraphy revealed that pve also induced a shift in hepatic function from the embolized part to the nonembolized part of the liver.Various hepatobiliary malignancies can be treated using pve, and pve is increasingly being used to expand the indication for major hepatectomy in patients with initially insufficient flr volume or function.The indication for pve is determined by the underlying liver function and standardized flr volume.In patients with chronic hepatitis, the histologic inflammatory activity was negatively correlated with the increase in flr volume, and pve is not suitable for patients with high serum 7s collagen concentrations (>8 ng/ml).This finding may predict the efficacy of pve.Pve before major hepatectomy can act as a tolerance test to avoid postoperative hepatic failure.Pve also improved long-term survival after liver resection in patients with hcc.Presently, pve is a safe and useful treatment for patients undergoing major hepatectomy.

Journal: Visceral medicine (2017)
Publication types: Journal Article;Review
FLT3 Inhibitors as Maintenance Therapy after Allogeneic Stem-Cell Transplantation.

Mutations in the flt3gene are associated with poor prognosis in patients with aml, even after consolidation with allogeneic hematopoietic cell transplantation (allo hct) in first remission.Treatment failure in flt3-mutated aml is largely driven by excessive risk of relapse compared to other genetic subtypes, including in patients post-allo hct.As a result, there is substantial interest in studying posttransplant maintenance therapy in flt3-mutated aml as an approach to optimize disease control and improve long-term outcomes.Clinical trials utilizing posttransplant flt3 inhibitors, such as sorafenib and midostaurin, have shown feasibility, safety, and encouraging posttransplant outcomes, and there are ongoing studies using newer-generation tyrosine-kinase inhibitors as posttransplant maintenance therapy.Here, we review the toxicities and efficacy of flt3 inhibitors as posttransplant maintenance, recommendations on the use of flt3 inhibitors by international consensus guidelines, and highlight key remaining questions.

Journal: Blood and lymphatic cancer : targets and therapy (2022)
Publication types: Journal Article;Review
Cannabinoids as Potential Molecules for Addiction Disorders.

Addictions are a group of chronic and recurrent diseases of the brain characterized by a pathological search for reward or relief through the use of a substance or other action.This situation implies an inability to control behavior, difficulty in permanent abstinence, a compelling desire to consume, decreased recognition of significant problems caused by behavior and interpersonal relationships, and a dysfunctional emotional response.The result is a decrease in the quality of life of the affected person, generating problems in their work, academic activities, social relationships, or family or partner relationships.Unfortunately, there are not enough pharmacotherapeutic solutions to treat addictions due to the complexity of their physiopathology and signaling pathways.Therefore, it is an imperative search for new pharmacological alternatives which may be used for this purpose.Purpose of review this review summarizes the main recent findings of the potential therapeutic effects of different cannabinoids on treating several addictions, including alcohol, opioids, methamphetamine, cocaine, and nicotine use disorders.Highlights standpoints: it has been demonstrated that many phyto, synthetic, and endogenous cannabinoids may act as therapeutic molecules in this psychiatric pathology through their action on multiple cannabinoid receptors.To highlight, cannabinoid receptors, types 1 and 2 (cb1 and cb2) have a crucial role in modulating the anti-addictive properties of these compounds.

Journal: Current protein & peptide science (2022)
Publication types: Journal Article;Review
Clinical significance of hemodialysis quality of care indicators in very elderly patients with end stage kidney disease.

Introduction improvement in life expectancy has increased the number of very elderly patients undergoing hemodialysis.However, it is not clear which quality measures for hemodialysis should be employed in this population.Therefore, in this paper we investigated the association between major adverse cardiovascular and cerebrovascular events (macce) indicators of hemodialysis quality in very elderly patients.Patients and methods: data regarding a total of 29,692 patients undergoing maintenance hemodialysis (median age 61 years, 41.5% females) who participated in a national hemodialysis quality assessment program were analyzed.They were divided into < 80 years and ≥ 80 years age groups.The primary and secondary outcomes were macce and all-cause mortality, respectively.The association between the outcomes and some of the most widely used standard hemodialysis quality-of-care indicators, including sp kt/v, hemoglobin, serum calcium, serum phosphate, and albumin levels, was evaluated.To explore the association between cox proportional hazard models were constructed.Model 1 was adjusted for age and sex.Model 2 included additional demographic characteristics, such as charlson comorbidity index (excluding diabetes), diabetes, cause of eskd, dialysis vintage, bmi, and pre-dialysis systolic blood pressure.Model 3 was further adjusted for the main medications.To evaluate the relationship between macce risk and quality assessment indicators as a continuous variable, cubic spline analyses were conducted.Results during a median follow-up of 3.7 years, macce occurred at a higher rate in the ≥ 80-years group than in the < 80-years group (282.0 vs.110.1 events/1000 person-years).Multivariate cox regression analysis revealed that sp kt/v, serum calcium and phosphate, and hemoglobin levels were associated with macce and all-cause mortality risk in patients aged < 80 years.However, these indicators showed no significant relationship with macce and all-cause mortality in patients aged ≥ 80 years.Low serum albumin levels were significantly associated with increased macce and all-cause mortality risks, regardless of age.Conclusion in conclusion, hemodialysis quality-of-care indicators including sp kt/v, serum calcium and phosphate levels, and hemoglobin were not related to macce or all-cause mortality in very elderly hemodialysis patients.However, lower serum albumin levels were associated with poor outcomes, regardless of patient age.Assuring nutritional status rather than improving hemodialysis management adequacy may be more beneficial for improving outcomes in very elderly hemodialysis patients.Further prospective evaluations are needed to confirm these findings.

Journal: Journal of nephrology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Differential gene expression analysis of common target genes for the detection of SARS-CoV-2 using real time-PCR.

Covid-19 currently is the main cause of the severe acute respiratory disease and fatal outcomes in human beings worldwide.Several genes are used as targets for the detection of sars-co v-2, including the rdrp, n, and e genes.The present study aimed to determine the rdrp, n, and e genes expressions of sars-co v- 2 in clinical samples.For this purpose, 100 sars-co v-2 positive samples were collected from diagnostic laboratories of mazandaran province, iran.After rna extraction, the real-time reverse transcription pcr (real-time rt-pcr) assay was performed for differential gene expressions' analysis of n, e, and rdrp.The threshold cycle (ct) values for n, rdrp, and e targets of 100 clinical samples for identifying sars-co v-2 were then evaluated using quantitative real-time pcr (q rt-pcr).This result suggests n gene as a potential target for the detection of the sars-co v-2, since it was observed to be highly expressed in the nasopharyngeal or oropharynges of covid-19 patients (p < 0.0001).Herein, we showed that sars-co v- 2 genes were differentially expressed in the host cells.Therefore, to reduce obtaining false negative results and to increase the sensitivity of the available diagnostic tests, the target genes should be carefully selected based on the most expressed genes in the cells.

Journal: AMB Express (2022)
Publication types: Journal Article
Effect of Balloon Pulmonary Angioplasty on Homogenization of Lung Perfusion Blood Volume by Dual-Energy Computed Tomography in Patients with Chronic Thromboembolic Pulmonary Hypertension.

Balloon pulmonary angioplasty (bpa) is used to treat patients with inoperable chronic thromboembolic pulmonary hypertension (cteph); the goal is to improve pulmonary perfusion.We aimed to evaluate lung perfusion blood volume (pbv) with haemodynamic and exercise-capacity parameters to assess the efficacy of bpa in the treatment of cteph.Methods we retrospectively studied 33 patients over a 6-year period.Dect pulmonary angiography was performed before and after bpa.Dect provided iodine distribution maps; whole-lung and regional pbv images and quantification were generated using post-processing software.A mosaic pattern suggesting perfusion inhomogeneity is typical in cteph.Hypothetically, bpa treatment would promote homogenization that would be reflected in the calculated standard deviation.Results lung perfusion images showed decreased heterogeneity after bpa.There was a significant difference before and after bpa in the whole-lung pbv and in the regional standard deviation for pulmonary arterial pressure (r = 0.37, p = 0.032 and r = 0.57, p = 0.006), pulmonary vascular resistance (r = 0.51, p = 0.023 and r = 0.60, p = 0.002), transtricuspid pressure gradient (r = 0.50, p = 0.0028 and r = 0.61, p = 0.0001), brain natriuretic peptide (r = 0.54, p = 0.0012 and r = 0.46, p = 0.0078), and 6-min walking distance (r = 0.59, p = 0.003 and r = 0.26, p = 0.14).The effects were especially pronounced after the first bpa procedure.Conclusion decreased lung heterogeneity may suggest bpa efficacy in treating cteph.After bpa treatment, improved lung pbv and improved regional standard deviation showed a strong positive correlation with haemodynamic parameters and exercise capacity, which also suggests that bpa is effective in treating cteph.

Journal: Lung (2021)
Publication types: Journal Article
POTENTIAL NEW-ONSET CLINICALLY DETECTABLE PENTOSAN POLYSULFATE MACULOPATHY YEARS AFTER DRUG CESSATION.

To describe a potential case of pentosan polysulfate maculopathy that seemed to manifest nearly 3 years after drug cessation.Methods complete ophthalmic examination, including multimodal fundus imaging, electroretinography, automated perimetry, and molecular testing, was performed.Results a 44-year-old woman with a 435 g cumulative exposure to pentosan polysulfate sodium presented 38 months after drug cessation with 6 months of worsening metamorphopsia and prolonged dark adaptation.Fundus examination and multimodal fundus imaging demonstrated characteristic features of pentosan polysulfate maculopathy, and molecular testing was unremarkable.By contrast, color fundus photographs of the same patient acquired at an outside facility 25 months before did not display features consistent with pentosan polysulfate sodium maculopathy.Conclusion this case suggests that new-onset clinically detectable pentosan polysulfate maculopathy may develop years after drug cessation.If corroborated, this finding has important ramifications for pentosan polysulfate sodium dosing and surveillance guidelines.

Journal: Retinal cases & brief reports (2022)
Publication types: Case Reports;Journal Article
Are personality disorders in bipolar patients more frequent in the US than Europe?

Bipolar patients in the united states (us) compared to those from the netherlands and germany (here abbrev.As "europe") have more axis i comorbidities and more poor prognosis factors such as early onset and psychosocial adversity in childhood.We wished to examine whether these differences also extended to axis ii personality disorders (pds).Methods 793 outpatients with bipolar disorder diagnosed by scid gave informed consent for participating in a prospective longitudinal follow up study with clinician ratings at each visit.They completed detailed patient questionnaires and a 99 item personality disorder inventory (pdq-4).Us versus european differences in pds were examined in univariate analyses and then logistic regressions, controlling for severity of depression, age, gender, and other poor prognosis factors.Results in the univariate analysis, 7 pds were more prevalent in the us than in europe, including antisocial, avoidant, borderline, depressive, histrionic, obsessive compulsive, and schizoid pds.In the multivariate analysis, the last 4 of these pds remained independently greater in the us than europe.Conclusions although limited by use of self report and other potentially confounding factors, multiple pds were more prevalent in the us than in europe, but these preliminary findings need to be confirmed using other methodologies.Other poor prognosis factors are prevalent in the us, including early age of onset, more childhood adversity, anxiety and substance abuse comorbidity, and more episodes and rapid cycling.The interactions among these variables in relationship to the more adverse course of illness in the us than in europe require further study.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (2022)
Publication types: Journal Article
Partners in School: Optimizing Communication between Parents and Teachers of Children with Autism Spectrum Disorder.

Partners in schoolis a consultation model with the goal of enhancing communication between two of the most important stakeholders in children's lives - parents and teachers.Using a single-group pre-post design, this preliminary study examined the effect of partners in schoolon parent-teacher communication outcomes and the factors associated with these outcomes.Participants were 26 teachers and 49 parents of children with autism spectrum disorder (asd).Parents and teachers completed surveys before and after participating in partners in school.Teachers reported an increase in their communication to parents.However, parents did not report an increase in their communication to teachers.Teachers' self-efficacy, expectations, and intervention fidelity were associated with increased communication to parents.Parental self-efficacy and teacher experience were associated with parents' reports of communication to teachers.Our findings suggest that family-school consultation services may be used to enhance teachers' communication with parents.

Journal: Journal of educational and psychological consultation : the official journal of the Association for Educational and Psychological Consultants (2021)
Publication types: Journal Article
In-vitro evaluation of the 5-fluorouracil loaded GQDs@Bio-MOF capped with starch biopolymer for improved colon-specific delivery.

Herein, for the first time, the photoluminescent graphene quantum dots@bio-metal organic framework (gqds@bio-mof) nanohybrid was prepared.Bet analysis obtained the average pore diameter of gqds@bio-mof about 11.97 nm.The existence of nanoscale porosity in gqds@bio-mof displays its suitability for 5-fu loading owing to the smaller size of 5-fu.5-fu entrapment efficiency and loading capacity were found to be ~42.04 % and ~4.20 %, respectively (5-fu@gqds@bio-mof).The 5-fu@gqds@bio-mof was capped with starch biopolymer (st@5-fu@gqds@bio-mof), fabricated sample displayed 4.67 for p hpzc.Sem analysis displayed that the st@5-fu@gqds@bio-mof microspheres have a spherical shape with a diameter of ~2 μm.The in vitro drug release assay displayed better release behavior for st@5-fu@gqds@bio-mof than 5-fu@gqds@bio-mof, releasing about 62.3 % of the entrapped 5-fu within 96 h of incubation.The 5-fu release showed the best fitting with the higuchi model with r20.9884.The in vitro cytotoxicity screening outcomes displayed that the st@gqds@bio-mof is a promising biocompatible carrier, with cell viability of higher than 84 %.Accumulation of the results revealed that the st@5-fu@gqds@bio-mof is a new system with advantages of sustained drug release and biocompatibility that are the main criteria for each newly designed anticancer drug carrier.

Journal: International journal of biological macromolecules (2022)
Publication types: Journal Article
The relation between average 1-year home blood pressure and the change in pro-BNP and left ventricle mass index.

The purpose of this investigation was to examine the association between average 1-year home blood pressure and the change in left ventricular mass index (lvmi) and pro-brain natriuretic peptide (bnp) levels.Methods this prospective study was a subgroup analysis of lifestyle intervention using mobile technology in patients with high cardiovascular risk: a pragmatic randomized clinical trial (light).In total, 242 patients were stratified into tertiles according to their average 1-year home blood pressure.Results patients grouped into the tertile 3 (t3) had a lower 1-year mean, sbp and dbp.The t3 group had a 2.1 times higher rate of decrease in pro-bnp and a 1.6 times higher rate of decrease in lvmi compared with t1, compared with the reference group.The area under curve (auc) value of average 1-year home blood pressure was higher than that of mean sbp or dbp.(auc, 0.75 vs.Auc, 0.70 vs.Auc, 0.69, respectively).Spearman rank correlation demonstrated that average 1-year home blood pressure had a correlation with δpro-bnp and δlvmi.Conclusion the present study showed that average 1-year home blood pressure may have a significant association with a decrease in lvmi and pro-bnp.Our study appears to be the first to evaluate the association between average 1-year home blood pressure and the change in lvmi and pro-bnp.

Journal: Blood pressure monitoring (2022)
Publication types: Journal Article;Randomized Controlled Trial
Influence and characteristics of Bacillus stearothermophilus in ammonia reduction during layer manure composting.

Ammonia emissions is an important issue during composting because it can cause secondary pollution and a significant of nitrogen loss.Based on research adding bacillus stearothermophilus can reduce ammonia emissions during composting because it can use sugar in organic matter fermentation to produce organic acids over 50 °c.This study conducted the batch experiments by adding different concentrations of bacillus stearothermophilus to reduce the ammonia emissions and find out its characteristic during layer manure composting by using an aerobic composting reactor with sawdust as a bulking agent.The results show that the application of bacillus stearothermophilus can accelerate the rate of temperature and significantly decrease p h, the warming period was 2 days in the treatment with bacillus stearothermophilus, while it was 4 days in the treatment without bacillus stearothermophilus.Ammonia emissions were mainly occurred in warming and high temperature period during composting.The ammonia emissions in the treatment with 8.00 g/kg initial bacillus stearothermophilus were significantly lower than the other lower bacillus stearothermophilus treatment and control during composting (p 0.05).Mi seq system sequencing results find that the addition of bacillus stearothermophilus changed the bacterial community structure under warming and high-temperature periods during composting, increased the relative abundance of lactic acid bacillus and nitrification bacteria.Therefore, the reason for the low ammonia emission in 8.00 g/kg initial bacillus stearothermophilus treatments might be not only due to the bacillus stearothermophilus itself, but also bacillus stearothermophilus can change the indigenous microorganism community, including increase the relative content of lactic acid bacillus and nitrification bacteria, thus reducing the p h and promoting nitrification, and reducing ammonia emissions.

Journal: Ecotoxicology and environmental safety (2019)
Publication types: Journal Article