syedzayyan/paper_mill_benchmark huggingface dataset:
Recurrence of Early Hepatocellular Carcinoma after Surgery May Be Related to Intestinal Oxidative Stress and the Development of a Predictive Model

Early stage hepatocellular carcinoma (hcc) has a high recurrence rate after surgery and lacks reliable predictive tools.We explored the potential of combining enhanced ct with gut microbiome to develop a predictive model for recurrence after early hcc surgery.Methods.A total of 112 patients with early hcc who underwent hepatectomy from september 2018 to december 2020 were included in this study, and the machine learning method was divided into a training group ( n = 71 ) and a test group ( n = 41 ) with the observed endpoint of recurrence-free survival (rfs).Features were extracted from the arterial and portal phases of enhanced computed tomography (ct) images and gut microbiome, and features with minimum absolute contraction and selection operator regression were created, and the extracted features were scored to create a preoperative prediction model by using the multivariate cox regression analysis with risk stratification analysis.Results.In the study cohort, the model constructed by combining radiological and gut flora features provided good predictive performance ( c index, 0.811 (0.650-0.972)).The combined radiology and gut flora-based model constructed risk strata with high, intermediate, or low risk of recurrence and different characteristics of recurrent tumor imaging and gut flora.Recurrence of early stage hepatocellular carcinoma may be associated with oxidative stress in the intestinal flora.Conclusions.This study successfully constructs a risk model integrating enhanced ct and gut microbiome characteristics that can be used for the risk of postoperative recurrence in patients with early hcc.In addition, intestinal flora associated with hcc recurrence may be involved in oxidative stress.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Study on Risk Factors and Nutritional Status of Postoperative Infection in Patients Undergoing Abdominal Surgery

In order to evaluate the risk factors of postoperative infection in patients undergoing abdominal surgery and the correlation with nutritional status, 143 patients admitted to our hospital for abdominal surgery from september 2020 to september 2021 are selected and analyzed.By collecting the clinical results and related pathological data of all patients, all patients are divided into the postoperative infection group (48 cases) and the noninfection group (95 cases) according to whether postoperative infection occurred.Firstly, the clinical data of the two groups are analyzed by univariate analysis.Secondly, the risk factors of postoperative infection in patients undergoing abdominal surgery are analyzed by binary logistic regression.Thirdly, the nutrition‐related indexes are compared, and the correlation between postoperative infection and serum nutritional indexes is analyzed by the spearman correlation coefficient.The results demonstrate that patients undergoing abdominal surgery have a certain risk of infection after surgery, and combination with underlying diseases is a risk factor for postoperative infection.In addition, poor preoperative nutritional status is also closely related to postoperative infection.It is suggested that serum pa and rbp indicators have certain predictive effects on postoperative infection.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Clinical Study;
The Effect of Skin-to-Skin Contact on Postoperative Depression and Physical Recovery of Parturients after Cesarean Section in Obstetrics and Gynecology Department

The effect of skin-to-skin contact (ssc) on postpartum depression and physical rehabilitation of cesarean section women was explored.280 parturients undergoing cesarean section were selected and were rolled into two groups randomly.The parturients in the control group (con group, 140 cases) received routine care, and those in the experimental group (exp group, 140 cases) received ssc on the basis of routine care.The postpartum depression and physical recovery of parturients in two groups were compared.It was found that, in the exp group, the number of pregnant women with no or with very mild depression was much more 85% vs.55%), the number of women with adequate lactation was more (53 cases vs.27 cases), the first lactation time (flt) was dramatically shorter ( 41.25 ± 4.81 h vs.58.43 ± 5.43 h ), the breastfeeding success rate (bfsr) and breastfeeding rate (bfr) were obvious higher, the days for uterine involution was much shorter ( 6.96 ± 1.13 days vs.9.47 ± 1.75 days), the descent of uterine fundus 24 hours after delivery (24 h-duf) was obviously larger ( 3.17 ± 0.26 mm vs.1.56 ± 0.43 mm), the duration of lochia (dol) was remarkably shorter ( 33.21 ± 5.32 days vs.25.32 ± 3.54 days), and the visual analogue scale (vas) score was lower ( 4.88 ± 0.32 points vs.3.41 ± 0.53 points), showing statistical differences for all above indicators ( p &lt; 0.05 ).It suggested that ssc could effectively relieve the postpartum depression of uterine parturients, promote the lactation, increase the bfr, facilitate uterine involution, and alleviate chronic uterine inflammation and postpartum pain, showing high clinical application and promotion value.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
The Establishment of a Mouse Model for Degenerative Kyphoscoliosis Based on Senescence-Accelerated Mouse Prone 8

Degenerative kyphoscoliosis (dks) is a complex spinal deformity associated with degeneration of bones, muscles, discs, and facet joints.The aim of this study was to establish an animal model of degenerative scoliosis that recapitulates key pathological features of dks and to validate the degenerative changes in senescence-accelerated mouse prone 8 (samp8) mice.Methods.Thirty male mice were divided into 2 groups: 10 bipedal c57bl/6j mice were used as the control group, and 20 bipedal samp8 mice were used as the experimental group.Mice were bipedalized under general anesthesia.The incidence of scoliosis and bone quality was determined using radiographs and in vivo micro-ct images 4, 8, and 12 weeks after surgery, respectively.Histomorphological studies of muscle samples were performed after sacrifice at 12 weeks after surgery.Results.On the 12th week, the incidence rates of kyphosis in c57bl/6j and samp8 groups were 50% and 100%, respectively.Overall, the incidence and angle of kyphosis were significantly higher in the bipedal samp8 group compared to the c57bl/6j group (44.7°± 6.2° vs.84.3°± 10.3°, p &lt; 0.001 ).Based on 3d reconstruction of the entire spine, degeneration of the intervertebral disc was observed in bipedal samp8 mice, including the reduction of disc height and the formation of vertebral osteophytes.The bone volume ratio (bv/tv) was significantly suppressed in the bipedal samp8 group compared with the bipedal c57bl/6j group.In addition, he staining and mason staining of the paraspinal muscle tissue showed chronic inflammation and fibrosis in the muscles of the bipedal samp8 group.Conclusions.The samp8 mouse model can be taken as a clinically relevant model of dks, and accelerated aging of the musculoskeletal system promotes the development of kyphosis.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
The Percutaneous Endoscopic Lumbar Debridement and Irrigation Drainage Technique for the First-Stage Treatment of Spontaneous Lumbar Spondylodiscitis: A Clinical Retrospective Study

Minimally invasive or open surgery is contentious in the treatment of spondylodiscitis, therefore finding a balance between the two is urgently needed.In this study, we propose a new treatment paradigm for treating spontaneous lumbar spondylodiscitis by percutaneous endoscopic lumbar debridement and irrigation drainage (peldid).Then, the pola classification was used to guide subsequent treatment.Methods.From november 2017 to april 2019, this study collected data on 16 patients with lumbar spondylodiscitis who were surgically treated utilizing this treatment paradigm in our department.Clinical effectiveness was determined using the visual analogue scale (vas), the oswestry disability index (odi), the mos 36-item short-form health survey (sf-36), and kirkaldy-willis criteria.Results.All 16 patients completed the treatment using the above paradigm and were followed up for 28.13 ± 10.15 months.The preoperative pola classification is as follows: 7 cases of type a, 3 cases of type b, and 6 cases of type c.After the first-stage surgery, the evaluation results of pola classification were as follows: 8 cases of type a, 8 cases of type b, and 0 cases of type c.Four patients received second-stage surgery with internal fixation through the paravertebral multifidus space approach and intervertebral bone graft fusion through the transforaminal approach, and the reoperation rate was 25% (4/16 cases).The visual analogue scale (vas), oswestry disability index (odi), and sf-36 score all improved significantly from 2.43 ± 0.89 to 0.18 ± 0.40 , from 77.31 % ± 11.15 % to 16.93 % ± 5.45 % , and from 18.34 ± 7.47 to 80.3 ± 15.36 .The crp and esr decreased dramatically from 49.61 ± 48.84 to 12.50 ± 12.18 and from 65.56 ± 26.89 to 29.68 ± 20.68 .There were no recurrences of infection in our study.Conclusions.The paradigm of the first-stage peldid technique combined with the pola classification system to guide the second-stage treatment for spontaneous spondylodiscitis is a novel and effective strategy for treating spontaneous spondylodiscitis.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
The Practices of Solid Waste Utility and Thriving Conditions of Logistics (a Case of Tepi Town): A Study to Treat the Healthy Environment

Unwanted remains, discarded residues, and byproduct materials that are not required by the initial user are known as wastes.In ethiopia, improper solid waste management becomes endemic and it affects the health conditions, comforts, and freedom of town communities.Improper solid waste management can also adversely affect infrastructure damages, socioeconomic conditions, and environmental and health problems.So, awareness creation among the communities is necessary.The main objective of the study was to assess the management of existing solid waste activities and reverse logistic systems in tepi town.The impacts of improper solid waste management were reduced through waste accumulation, transportation, recycling, and waste removal.Available pieces of information for the study were gathered from 450 near house places and 549 survivals.The collected data were analyzed by using vensim system dynamics software, and the obtained results were modeled by a system dynamic cause and effect relationship diagram.Finally, the appropriate recommendations for communities, municipals, and institutions were provided.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
Radioanatomical Study of the Skull Base and Septum in Chinese: Implications for Using the HBF for Endoscopic Skull Base Reconstruction

Radioanatomy provides surgeons with different choices to prevent the failure of reconstruction caused by improper flap selection and the occurrence of csf leakage or other severe complications.To establish a radioanatomical model, this study radioanatomically investigated the use of the hadad–bassagasteguy nasoseptal flap (hbf) in skull base reconstruction performed via the transethmoidal, transsphenoidal, and transclival approaches to provide preoperative guidance for the selection of approaches for skull base reconstruction and preparation of the hbf.Methods.The computed tomography images of 40 chinese adults were selected for the radioanatomical measurement of data related to the hbf and skull base reconstruction via the transethmoidal, transsphenoidal, and transclival approaches.The results were analyzed using radioanatomy combined with spss-based analysis.Results.In the 40 patients, the area of the hbf exceeded that of skull base defects reconstructed via the transethmoidal approach by 10.21 ± 1.97 c m 2 , and the anterior margin width, posterior margin width, upper margin length, and lower margin lengths of the hbf all exceeded the corresponding values of skull base defects requiring reconstruction by at least 8.4 mm.The area of the hbf exceeded that of reconstructed skull base defects by an average of 10.72 ± 2.04 c m 2 .The area of the hbf exceeded that of skull base defects reconstructed via the transclival approach by 9.01 ± 2.87 c m 2 .The difference between the anterior margin width of the hbf and the middle width of skull base defects reconstructed via the transclival approach did not exceed 6 mm in only one case (5.4 mm).Conclusion.In chinese adults, the hbf can cover skull base defects reconstructed via the transethmoidal, transsphenoidal, and transclival approaches, permitting its use in skull base reconstruction performed via all three approaches.Radioanatomy can be used for preoperative guidance to plan surgery via the transethmoidal, transsphenoidal, and transclival approaches.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Value of CT Radiomics and Clinical Features in Predicting Bone Metastases in Patients with NSCLC

To explore the ct radiomic features and clinical imaging features of the primary tumor in patients with nonsmall cell lung cancer (nsclc) before treatment and their predictive value for the occurrence of bone metastases.Methods .From june 2017 to june 2021, 195 patients with nsclc who were pathologically diagnosed without any treatment in the cancer hospital affiliated to hainan medical college were retrospectively analyzed, and they were divided into a bone metastasis group and a nonbone metastasis group.The relationship between clinical imaging features and bone metastasis in patients was analyzed by the t ‐test, rank sum test, and χ 2 test.At the same time, itk software was used to extract the radiomic characteristics of the primary tumor of the patients, and the patients were randomly divided into a training group and a validation group in a ratio of 7 : 3.The training model was validated in the validation group, and the performance of the model for predicting bone metastases in nsclc patients was verified by the roc curve, and a multivariate logistic regression prediction model was established based on the omics parameters extracted from the best prediction model combined with clinical image features.Results .Seven features were screened from the primary tumor by lasso to establish a model for predicting metastasis.The area under the curve was 0.82 and 0.73 in the training and validation sets.The best omics signature and univariate analysis suggested clinical imaging factors ( p &lt; 0.05) associated with bone metastases were included in multivariate binary logistic analysis to obtain clinical characteristics of the primary tumor such as gender (or = 0.141, 95% ci: 0.022–0.919, p = 0.04), increased cyfra21‐1 (or = 0.12, 95% ci: 0.018–0.782, p = 0.027), fe content in blood (or = 0.774, 95% ci: 0.626–0.958, p = 0.018), ct signs such as lesion homogeneity (or = 0.052, 95% ci: 0.006–0.419, p = 0.006), pleural indentation sign (or = 0.007, 95% ci: 0.001–0.696, p = 0.034), and omics characteristics glszm_small area high gray level emphasis (or = 0.016, 95% ci: 0.001–0.286, p = 0.005) were independent risk factors for bone metastasis in patients.Conclusion .The prediction model established based on radiomics and clinical imaging features has high predictive performance for the occurrence of bone metastasis in nsclc patients.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Psychosocial Factors and Psychological Characteristics of Personality of Patients with Chronic Diseases Using Artificial Intelligence Data Mining Technology and Wireless Network Cloud Service Platform

It was to explore the application value of health cloud service platform based on data mining algorithm and wireless network in the analysis of psychosocial factors and psychological characteristics of personality of patients with chronic diseases.Based on the demand analysis of cloud service platform for chronic diseases, a health cloud service platform including three modules was established: support layer, application layer, and interaction layer; and k-means algorithm and apriori algorithm were used to mine and process data.The changes of pulse wave and eeg signal of epileptic seizures before and after processing by wireless network health cloud service platform were analyzed.42 patients with idiopathic generalized epilepsy were selected as the research subjects, and 40 volunteers with normal physical examination during the same period were selected as the control group.The differences in the basic clinical characteristics data, hamilton anxiety scale (hama), hamilton depression scale (hamd), symptom checklist 90 (scl-90), and eysenck personality questionnaire-revision short scale for chinese (epq-rsc) were compared between the two groups.It was found that the initial eeg signals of epileptic patients had noise pollution before and after the seizure, and the noise in the eeg signals was filtered out after digital technology processing in the cloud service platform.The maximum number of epileptic patients aged 18∼30 years was 17 (40.48%), and the mean scores of hamd and hama scales in the epileptic group were significantly higher than those in the control group ( p &lt; 0.001 ).The total score of scl-90, somatization, obsessive-compulsive symptoms, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychosis in the epilepsy group were obviously higher than those in the control group ( p &lt; 0.01 ).The mean value of epq-rsc and neuroticism (n) was clearly higher ( p &lt; 0.05 ), the mean value of extroversion (e) was significantly lower ( p &lt; 0.01 ), and the mean value of lie scale was significantly higher ( p &lt; 0.05 ) in the epileptic group in contrast with those in the control group.It indicates that the cloud service platform for chronic diseases based on artificial intelligence data mining technology and wireless network has potential application value.Epilepsy patients with chronic diseases should be paid more attention to their psychosocial factors and psychological characteristics of personality in the treatment process.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
PSSPNN: PatchShuffle Stochastic Pooling Neural Network for an Explainable Diagnosis of COVID-19 with Multiple-Way Data Augmentation

Covid-19 has caused large death tolls all over the world.Accurate diagnosis is of significant importance for early treatment.Methods.In this study, we proposed a novel psspnn model for classification between covid-19, secondary pulmonary tuberculosis, community-captured pneumonia, and healthy subjects.Psspnn entails five improvements: we first proposed the n-conv stochastic pooling module.Second, a novel stochastic pooling neural network was proposed.Third, patch shuffle was introduced as a regularization term.Fourth, an improved multiple-way data augmentation was used.Fifth, grad-cam was utilized to interpret our ai model.Results.The 10 runs with random seed on the test set showed our algorithm achieved a microaveraged f1 score of 95.79%.Moreover, our method is better than nine state-of-the-art approaches.Conclusion.This proposed psspnn will help assist radiologists to make diagnosis more quickly and accurately on covid-19 cases.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
Prophylactic Use of Antibiotics for Postsurgical Infection in c-TACE and DEB-TACE High-Risk Patients: A Case-Control Study

S.According to recent reports, prophylactic use of antibiotics is not always required in conventional transarterial chemoembolization (c-tace).However, clinical evidence of prophylactic antibiotics in drug-eluting beads transarterial chemoembolization (deb-tace) to prevent postsurgical infection is limited.This study is aimed to evaluate the correlation between the preoperative prophylactic application of antibiotics and postoperative infection in c-tace or deb-tace, especially in a population with a high risk for postsurgical infection.Methods.In this retrospective study, tace patients diagnosed with hepatic carcinoma (between january 2019 and may 2021) were examined.The case group was given 1.5 g cefuroxime sodium 0.5–1 hour before tace, while there was no intervention in the control group.The outcomes analyzed were leukocyte count &gt;9.5 × 109/l on the second day after the operation and the diagnosis of infection within one month after the operation.We applied univariate, multivariate logistic regression, trend analysis, and subgroup analysis to find potential risk factors and the necessity of prophylactic antibiotics.Results.Among 142 eligible cases, 72 received antibiotics while 70 were kept as control, 113 cases were treated with c-tace, and 29 were treated with deb-tace.Multivariate analysis showed that the increase in white blood cell count after the operation was related to diabetes (or 5.112, 95% ci 1.229–21.264, p = 0.025).The occurrence of postoperative infection was negatively correlated with preoperative albumin value (<25 g/l) (or 153.118, 95% ci 1.631–14372.331, p = 0.030).Trend analysis showed that the risk of postoperative infection increased with a decrease in serum albumin level (p &lt; 0.05).Subgroup analysis showed that there were no significant differences in the incidence of increased leukocyte count and postoperative infection between the prophylactic and nonprophylactic treatment groups, in the case of diabetes, preoperative albumin levels, and operation mode (p &gt; 0.1).Conclusions.Prophylactic antibiotic treatment before the c-tace or deb-tace had no significant correlation with postoperative leukocyte increase and postoperative infection.Diabetes history and serum albumin levels were the prominent risk factors associated with an increase in postoperative leukocyte count and postoperative infection.Future large-scale studies and randomized-controlled trials are required to confirm and validate this association.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Preliminary Study on the Application of Nanochitosan Film and Petrolatum Gauze in the Modified Devine Operation

Although the use of sterile petroleum jelly gauze combined with nanochitosan film to wrap wounds has been proven to have good results, it has not been applied for modified devine surgery.The use of sterile petroleum jelly gauze alone in the modified devine surgery to treat concealed penis in children has different effects.In this study, the systematic evaluation of the effect of the modified devine technique (vaseline gauze bandaging the wound) in the treatment of concealed penis in children is conducted.Furthermore, the application of nanochitosan film and vaseline gauze in the modified devine technique is proposed.By analytical search in pub med, china knowledge network (ckn), and other chinese and foreign literature databases, there are 13 studies describing the development of the penis during the follow‐up period with high satisfaction of patients and their family members.In addition, systematic evaluations have shown that the complete removal of the fibrotic penile sarcoid tissue is an important reason for the remarkable curative effect of the modified devine surgery in the treatment of concealed penis in children.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Review Article;