syedzayyan/paper_mill_benchmark huggingface dataset:
Differentiating nonradiographic axial spondyloarthritis from its mimics: a narrative review.

Optimal treatment of nonradiographic axial spondyloarthritis depends on accurate and timely diagnosis of the underlying disease; however, patients present with common symptoms that, in the absence of radiographic changes, may confound diagnosis.Methods and findings in this narrative review, a pub med literature search was conducted through january 2021, with no date limits, to identify english-language publications discussing classification of nonradiographic axial spondyloarthritis, with an emphasis on clinical features and presentation, differential diagnoses, and mimics of disease.This review describes the epidemiology, clinical features, and burden of disease of nonradiographic axial spondyloarthritis as it relates to the overall axial spondyloarthritis spectrum and discusses mimics and differential diagnoses of nonradiographic axial spondyloarthritis that should be considered when evaluating patients with suspected nonradiographic axial spondyloarthritis in clinical practice.Conclusions recognition of clinical features of nonradiographic axial spondyloarthritis, along with an understanding of comorbid conditions such as fibromyalgia, allows for differentiation from its mimics.Appropriate diagnosis of nonradiographic axial spondyloarthritis is important for aggressive management of disease to reduce pain, avoid loss of function, and improve quality of life.

Journal: BMC musculoskeletal disorders (2022)
Publication types: Journal Article;Review
Encapsulating mesoporous metal nanoparticles: towards a highly active and stable nanoreactor for oxidative coupling reactions in water.

We design and prepare a highly active and stable nanoreactor via encapsulating various mesoporous metal nanoparticles with an amphiphilic hollow shell, which presents excellent performance in oxidative coupling reactions in water for efficient production of α,β-unsaturated ketones.

Journal: Chemical communications (Cambridge, England) (2019)
Publication types: Journal Article
Development of Hydrophilic PVDF Membrane Using Vapour Induced Phase Separation Method for Produced Water Treatment.

During the production of oil and gas, a large amount of oily wastewater is generated, which would pollute the environment if discharged without proper treatment.As one of the most promising treatment options, membrane material used for oily wastewater treatment should possess desirable properties of high hydraulic performance combined with high membrane fouling resistance.This project employs the vapor induced phase separation (vips) technique to develop a hydrophilic polyvinylidene fluoride (pvdf) membrane with polyethylene glycol (peg) as an additive for produced water treatment.Results show that thanks to its slow nonsolvent intake, the vips method hinders additive leaching during the cast film immersion.The results also reveal that the exposure of the film to the open air before immersion greatly influences the structure of the developed membranes.By extending the exposure time from 0 to 30 min, the membrane morphology change from typical asymmetric with large macrovoids to the macrovoid-free porous symmetric membrane with a granular structure, which corresponds to 35% increment of steady-state permeability to 189 l·m-2h-1bar-1, while maintaining >90% of oil rejection.It was also found that more peg content resides in the membrane matrix when the exposure time is extended, contributes to the elevation of surface hydrophilicity, which improves the membrane antifouling properties.Overall results demonstrate the potential of vips method for the fabrication of hydrophilic pvdf membrane by helping to preserve hydrophilic additive in the membrane matrices.

Journal: Membranes (2020)
Publication types: Journal Article
Incidence of Psoriasis in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Matched Cohort Study.

Emerging data suggest that inflammatory bowel disease (ibd) and psoriasis are associated, sharing common genetic predispositions and immunological mechanisms.However, concrete data on psoriasis risk in ibd patients compared to the general population are limited.Objective we investigated the risk of developing psoriasis in ibd patients compared to controls without ibd.Methods using the korean national health insurance database, patients diagnosed with crohn's disease (cd) or ulcerative colitis (uc) between 2005 and 2008 were age- and sex-matched 1:4 to non-ibd subjects from 2003 to 2018.Ibd patients were defined by combining the international classification of diseases 10th revision code and at least one prescription of ibd-specific medications.Disease phenotypes, including psoriasis severity and psoriatic arthritis, were also identified.We investigated newly diagnosed psoriasis from 2009 to 2018.Incidence rates and risk of psoriasis were assessed with multivariate cox regression models.Subgroup analyses for age and sex, and sensitivity analysis involving tumor necrosis factor (tnf) inhibitor-naïve patients were performed.Results during nearly a decade of follow-up, 20,152 ibd patients were identified (14,619 [72.54%] uc and 5,533 [27.46%] cd).Among them, 439 patients were newly diagnosed with psoriasis (incidence rate of 217.68 per 100,000 person-years and 228.62 per 100,000 person-years for uc and cd, respectively).The psoriasis risk was higher in ibd patients than in the matched controls (adjusted hazard ratio, a hr, 2.95, 95% confidence interval, ci, 2.60-3.33).Moreover, ibd patients aged <30 years were at an increased risk (a hr 3.35, 95% ci 2.58-4.35), a trend that was unchanged across all psoriasis phenotypes.Sensitivity analysis of tnf inhibitor-naïve patients revealed consistent results.Conclusions ibd patients were more likely to develop psoriasis compared to non-ibd subjects, including younger patients at an elevated risk regardless of tnf inhibitor use.This advocates the interplay between ibd and psoriasis; thus, inspection of cutaneous manifestation and dermatological consultation may be helpful in ibd patients at risk.

Journal: Dermatology (Basel, Switzerland) (2021)
Publication types: Journal Article
Application of BP Neural Networks in Garment Pattern Design System.

With the intensification of global market competition and the continuous development of the information technology, competition in the apparel market has become increasingly fierce.The key to whether china's garment industry can maintain its advantage in the international market competition in the future lies in whether it can promote and realize the informatization of the garment industry or not.After all, under the context of increasingly developed information technologies and growing competition in the garment market, mass customization of garments has become a future trend in the garment industry.As custom-made clothing is more in line with consumers' individual needs in terms of style, fabric, and size, the focus of development for clothing companies is increasingly on the grasp of the fit of clothing.However, with china's large population and the wide variety of body types, traditional hand-made garments are time-consuming and cannot meet the differentiated needs of consumers in the modern market.The design of garment samples is an important part of the industrial production of garments and is highly dependent on the skills and experience of the operators.In other words, the level of technical expertise can determine the quality and shape of a garment product to a certain extent.As a result, in order to further improve the efficiency and quality of garment sample design and to reduce the dependence on operator skills and experience, this study proposes an intelligent garment paper sample design system based on bp neural networks.The system mainly utilizes the self-learning, self-organizing, and adaptive as well as nonlinear mapping functions of artificial neural networks to design clothing samples autonomously, thus improving the design efficiency.In the era of rapid development of information technology and artificial intelligence technology, the development of intelligent garment pattern design systems with independent intellectual property rights is of great significance in promoting the prosperity of the garment industry.

Journal: Computational intelligence and neuroscience (2022)
Publication types: Journal Article
Ca2+-independent phospholipase A2β-derived PGE2contributes to osteogenesis.

Bone modeling can be modulated by lipid signals such as arachidonic acid (aa) and its cyclooxygenase 2 (cox2) metabolite, prostaglandin e2(pge2), which are recognized mediators of optimal bone formation.Hydrolysis of aa from membrane glycerophospholipids is catalyzed by phospholipases a2(pla2s).We reported that mice deficient in the ca2+- independent pla2beta (i pla2β), encoded by pla2g6, exhibit a low bone phenotype, but the cause for this remains to be identified.Here, we examined the mechanistic and molecular roles of i pla2β in bone formation using bone marrow stromal cells and calvarial osteoblasts from wt and i pla2β-deficient mice, and the mc3t3-e1 osteoblast precursor cell line.Our data reveal that transcription of osteogenic factors (bmp2, alpl, and runx2) and osteogenesis are decreased with i pla2β-deficiency.These outcomes are corroborated and recapitulated in wt cells treated with a selective inhibitor of i pla2β (10 μm s-bel), and rescued in i pla2β-deficient cells by additions of 10 μm pge2.Further, under osteogenic conditions we find that pge2production is through i pla2β activity and that this leads to induction of runx2 and i pla2β transcription.These findings reveal a strong link between osteogenesis and i pla2β-derived lipids and raise the intriguing possibility that i pla2β-derived pge2participates in osteogenesis and in the regulation of runx2 and also i pla2β.

Journal: Prostaglandins & other lipid mediators (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, U.S. Gov't, Non-P.H.S.
The impact of the ongoing COVID-19 pandemic on the management of rheumatic disease: a national clinician-based survey.

This study aims to investigate the impact of the coronavirus disease 2019 (covid-19) pandemic on the management of rheumatic diseases (rd).An online survey included 10 questions were designed to assess potential differences in rheumatology practice.The survey was conducted between march 2021 and june 2021.Marginal homogeneity test was used to compare frequencies of outpatient clinic patients between the pre-pandemic and pandemic.Other results were analyzed by descriptive statistics.One hundred three clinicians (75.7% in rheumatology practice for at least five years) responded to the survey.Almost 70% examined < 30 patients per day during the pandemic while nearly 70% examined ≥ 30 patients per day before the pandemic (p < 0.001).They indicated following reasons for decreasing outpatient clinic activity were concerns regarding covid-19 transmission risk of the patients (95%) and the clinicians (53%), being able to supply chronic medications directly from the pharmacy (85%), lockdown (71%), limited outpatient appointments (64%) and using telemedicine (20%).The frequencies of rheumatology daily routine procedures were decreased as follows; patient hospitalization for diagnosing (80%) and treatment (78%), labial salivary gland biopsy (63%), schirmer's test/salivary flow rate test (56%), nail bed video-capillaroscopy (52%), musculoskeletal ultrasonography (51%) and pathergy test (50%).Clinicians hesitated to use rituximab (63%) mostly, followed by cyclophosphamide (53%), glucocorticoids (43%), tofacitinib (41%), mycophenolate mofetil (36%), and azathioprine (33%).In this first national survey, the prominent differences in the management of rd have decreased outpatient clinic activity, reduced rheumatology daily procedures, and hesitancy to use some rheumatic drugs.

Journal: Rheumatology international (2022)
Publication types: Journal Article
Mental health among patients with chronic musculoskeletal pain and its relation to number of pain sites and pain intensity, a cross-sectional study among primary health care patients.

Chronic musculoskeletal pain (cmp) is characterised by pain related to the muscles or the joints with a duration of three months or more and is associated with high symptomatic burden in patients in primary health care.Cmp is commonly associated with impaired mental health, which may affect the rehabilitation process.The primary aim of this study was to compare symptoms of anxiety, depression, fatigue, and insomnia in patients in primary health care with and without cmp.The secondary aim was to assess difference in mental health symptoms related to number of pain sites and pain intensity.Methods this cross-sectional study was conducted in trondheim, norway.All patients aged 21-58 from randomly selected general practitioners (gps) were invited to participate.Participants were classified into two groups according to presence of cmp.Symptoms of anxiety, depression, fatigue, and insomnia were assessed by the hospital anxiety and depression scale (hads), chalder fatigue questionnaire (cfq), and insomnia severity index (isi), respectively, using an online survey system.Results from the patient lists of six gps, we included 969 patients.Mean age 46 years (sd: 10.1), and 517 reported cmp.Cmp patients reported higher mean symptom score for anxiety (5.4 vs 3.7), depression (3.4 vs 2.0), fatigue (14.2 vs 11.2), and insomnia (8.1 vs 4.4), all p < 0.01 compared to no-cmp patients.Symptoms of impaired mental health increased with increasing number of pain sites and pain intensity (p < 0.001).Conclusions primary health care patients with cmp reported significantly more symptoms of anxiety, depression, fatigue, and insomnia than patients without cmp.The higher number of pain sites and pain intensity, the more mental health symptoms, especially of anxiety.Primary health care personnel have to address mental health issues when treating patients with cmp.Trial registration clinicaltrials.gov (nct02020772, 25/12/2013).

Journal: BMC musculoskeletal disorders (2022)
Publication types: Journal Article
Histological Evidence of Wound Healing Improvement in Rats Treated with Oral Administration of Hydroalcoholic Extract ofVitis labrusca.

Plant extracts rich in phenolic compounds have been demonstrated to accelerate wound healing, but their use by oral route has been poorly studied.The leaves of vitis labruscaare rich in phenolic acids and flavonoids.The goal of this study was to assess the healing properties of the oral administration of hydroalcoholic extract of v.Labruscaleaves (hevl) in a murine model.Hevl was obtained by soxhlet and dynamic maceration, and their yield and phenolic acids and flavonoid contents were determined.For the wound healing assay, 8 mm wounds were performed on the back of 48 wistar rats, assigned into four groups (n= 12): ctr (distilled water), hevl100, hevl200, and hevl300 (hevl at 100, 200, and 300 mg/kg, respectively).On days 7 and 14, wound closure rates were assessed, and the healing wounds were subjected to histological analysis.Soxhlet-obtained extract was selected for the wound healing assay because it provided a higher yield and phenolic acid and flavonoid contents.Hevl significantly reduced leukocytosis in the peripheral blood (p< 0.05), accelerated wound closure (p< 0.05), and improved collagenization (p< 0.05) on day 7, as well as enhanced the epidermal tissue thickness (p< 0.001) and elastic fiber deposition on day 14 (p< 0.01).Furthermore, hevl promoted an increase in the histological grading of wound healing on both days 7 and 14 (p< 0.01).The doses of 200 and 300 mg/kg provided better results than 100 mg/kg.Our data provide histological evidence that the oral administration of hevl improves wound healing in rodents.Therefore, the extract can be a potential oral medicine for healing purposes.

Journal: Current issues in molecular biology (2021)
Publication types: Journal Article
Assisted oocyte activation with calcium ionophore 44 hours after intracytoplasmic sperm injection resulting in successful pregnancy.

Assisted oocyte activation (aoa) with calcium ionophore, is possible to manually activate the oocytes and cure globozoospermia, thus leading to successful pregnancy in 1 h after icsi.But in this case, we report a case that 44 h after icsi, the arrest zygotes assisted oocyte activation with calcium ionophore, obtained clinical pregnancy and live birth.Accordingly, aoa may provide us with an immediate treatment for embryonic arrest in the future.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2020)
Publication types: Case Reports;Journal Article
Performance of Saliva Samples for COVID-19 Diagnosis by Using the AllplexTM2019-nCoV Assay Kit.

Although the nasopharyngeal swab (nps) is the reference sampling method for the detection of sars-cov-2, it is not always possible to collect nps in some patients.Saliva represents an interesting sampling method because it is less invasive and more convenient in patients with nasal or pharyngeal lesions.objective:to compare the rt-q pcr test performances of saliva samples with nasal mid-turbinate swab (nmts) and nps samples in a cohort of ambulatory patients suspected of having covid-19.study design:for each of the 112 enrolled patients, nps, nmts, and saliva samples were collected and tested for sars-cov-2 detection using three different target genes (rd rp, n and e genes) by rt-q pcr.results:among the positive samples (56/112), saliva samples showed a lower percentage of sars-cov-2 detection compared to nps samples, (85.7vs.96.4%), while still a lower percentage was observed for nmts samples (78.6%).In average, saliva samples showed higher ct values for all tested target genes, compared to those from nps and nmts samples.conclusions:by using the allplex tm2019-n co v assay kit, saliva samples showed lower sensitivity for sars co v-2 compared to nps samples; however, the not detected cases had lower viral burden in nps samples (ct values >33) representing an interesting alternative sampling method in patients in which it is not possible to take a nps sample.

Journal: Frontiers in medicine (2021)
Publication types: Journal Article
Current Genetic Status of Nagaremon-charr, a Threatened Morphotype ofSalvelinus leucomaenisin the Ane River, Lake Biwa System, Central Japan, With Comments on Its Conservation.

Stream-dwelling white-spotted charr,salvelinus leucomaenis, populations tend to have unique color and spot patterns in different regions and may even display stream-specific patterns.An extreme edge of such diversity, found in individuals with atypical body color patterns (so-called nagaremon-type charr, a rare morphotype of salvelinus leucomaenis[hereafter termed nagaremon-charr]), sympatrically occurring with normal-charr, has been reported from only six small isolated populations in japan.Based on morphological and ecological perspectives, nagaremon-charr has been considered as an intraspecific color variant of white-spotted charr, although the genetic status of nagaremon-charr has not been determined.In this study, genetic diversity and population structure of the nagaremon-charr in a tributary of the ane river (lake biwa system) were investigated through microsatellite and mt dna analyses.Nagaremon-charr and sympatric normal-charr in the tributary shared the mt dna haplotypes and were assigned to the same cluster in the structure analysis and discriminant analysis of principal components (dapc).These results suggested that nagaremon-charr in the ane river is an intra-populational specific color variant of white-spotted charr.Above a waterfall, nagaremon-charr specimens exhibited extremely reduced genetic diversity, indicating that genetic drift may account for the fixation of the nagaremon-morphotype.Normal-charr below the waterfall clustered separately from hatchery-reared charr, indicative of native status of the former.Thus, both nagaremon-charr and normal-charr in the entire ane river tributary should be conserved.

Journal: Zoological science (2022)
Publication types: Journal Article
Comprehensive Evaluation of Factors Affecting Tremor Relapse after MRgFUS Thalamotomy: A Case-Control Study.

To identify possible relevant factors contributing to tremor relapse after mrg fus thalamotomy in patients with essential tremor (et) and parkinson's disease (pd).Methods we identified patients with tremor relapse from a series of 79 treatments in a single institution.The demographic and clinical characteristics of the study group patients were compared to those of patients who did not relapse in the same follow-up period.Imaging and procedural factors were compared using a control group matched for clinical and demographic characteristics.Results concerning clinical and demographic characteristics, we did not find statistically significant differences in gender and age.Seventy-three percent of patients with tremor relapse were parkinson's disease patients.Using mri, we found larger thalamotomy lesions at the 1-year follow-up in the control group with stable outcomes, compared to patients with tremor relapse.In the tractography evaluation, we found a more frequent eccentric position of the drtt in patients with tremor relapse.Conclusions the most relevant determining factors for tremor relapse after mrg fus thalamotomy appear to be tremor from parkinson's disease and inaccurate thalamic targeting.Size of the thalamotomy lesion can also influence the outcome of treatment.

Journal: Brain sciences (2021)
Publication types: Journal Article
dSTORM Imaging and Analysis of Desmosome Architecture.

Desmosomes are cell-cell junctions responsible for mechanically integrating adjacent cells.Due to the small size of the junctions, their protein architecture cannot be elucidated using conventional fluorescence microscopy.Super-resolution microscopy techniques, including d storm, deliver higher-resolution images which can reveal the localization or arrangement of proteins within individual desmosomes.Herein we describe an imaging and analysis method to determine the nanoscale architecture of desmosomes using super-resolution d storm.

Journal: Methods in molecular biology (Clifton, N.J.) (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, U.S. Gov't, Non-P.H.S.
Impact of mutations in SARS-COV-2 spike on viral infectivity and antigenicity.

Since the outbreak of sars-co v-2, the etiologic agent of the covid-19 pandemic, the viral genome has acquired numerous mutations with the potential to alter the viral infectivity and antigenicity.Part of mutations in sars-co v-2 spike protein has conferred virus the ability to spread more quickly and escape from the immune response caused by the monoclonal neutralizing antibody or vaccination.Herein, we summarize the spatiotemporal distribution of mutations in spike protein, and present recent efforts and progress in investigating the impacts of those mutations on viral infectivity and antigenicity.As mutations continue to emerge in sars-co v-2, we strive to provide systematic evaluation of mutations in spike protein, which is vitally important for the subsequent improvement of vaccine and therapeutic neutralizing antibody strategies.

Journal: Briefings in bioinformatics (2022)
Publication types: Journal Article