syedzayyan/paper_mill_benchmark huggingface dataset:
The Diagnostic Accuracy of Transabdominal and Transvaginal Color Doppler Ultrasound for Pregnant Women with Vasa Previa and Velamentous Cord Insertion

The objective of this study is to evaluate feasibility and accuracy of transabdominal color doppler ultrasound (ta‐cdus) and transvaginal color doppler ultrasound (tv‐cdus) as screening methods for pregnant women with vasa previa (vp) and velamentous cord insertion (vci).Methods .A retrospective diagnostic accuracy study was performed on 5,434 pregnant women from 2018 to 2021, who underwent both ta‐cdus and tv‐cdus.Diagnostic performance of ta‐cdus and tv‐cdus was determined using specificity, positive predictive value (ppv), negative predictive value (npv), accuracy, and positive and negative likelihood ratios (lr + and lr - ), using the delivery information (gross examination) as the “gold‐standard”.Patient records were reviewed for demographics and diagnosis.Results .The combination of vp and vci was diagnosed in 37/5434 (0.68%) women at delivery.The sensitivity, specificity, ppv, npv, and overall test accuracy of ta‐cdus were 72.97%, 99.85%, 77.14%, 99.81%, and 99.67%, respectively, for diagnosing vp with vci.The corresponding values for tv‐cdus were 89.19%, 99.87%, 82.50%, 99.93%, and 99.80%, respectively.Moreover, the sensitivity of combination of ta‐cdus and ta‐cdus in determining vp with vci was 97.30%, specificity 99.98%, ppv 97.30%, npv 99.98%, and accuracy 99.96%.No significant difference in the misdiagnosis and missed diagnosis was found between the examination by ta‐cdus and tv‐cdus.Conclusions .Both ta‐cdus and tv‐cdus can be acceptable diagnostic tools for assessment of pregnant women with vp and vci, with a better application of tv‐cdus with higher accuracy.The combination of ta‐cdus and tv‐cdus could provide an objective imaging basis for choosing clinical treatment strategies and predicting prognosis.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
The Application of the GP Model to Manage Controllable Risk Factors in Stroke Patients with Diabetes Can Effectively Improve the Prognosis and Reduce the Recurrence Rate

The aim of this study is to examine the impacts of general practice model (gp) on prognosis and recurrence of stroke patients with diabetes.Methods.Ninety patients with stroke combined with diabetes mellitus admitted to our hospital from june 2019 to june 2020 were selected for the study and were randomly and equally divided into 45 cases each in the control and experimental groups for the prospective trial.The patients in the control group received routine treatment while those in the experimental group were treated with gp model.Comparison in treatment effects, patients satisfaction, psychological status, quality of life, glycosylated hemoglobin level, and stroke recurrence was carried out between the two groups.Results.The experimental group showed markedly better treatment effects ( p &lt; 0.05 ), higher satisfaction degree ( p &lt; 0.05 ), higher had ( p &lt; 0.05 ), gqoli-74 score ( p &lt; 0.05 ), and bi index ( p &lt; 0.05 ), lower level of glycosylated hemoglobin ( p &lt; 0.05 ), and much lower recurrence rate ( p &lt; 0.05 ), as compared to the control group.Conclusion.The application of the gp model to manage controllable risk factors in stroke patients with diabetes can effectively improve the prognosis and reduce the recurrence rate, which is worthy of clinical application and promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
The Application and Efficacy Evaluation of Autologous Fat Transplantation in Antiaging of the Face: Systematic Review and Meta-Analysis

To evaluate the therapy of autologous fat fine-grain transplantation in the application of antiaging facial by metaelaboration method.Methods.In chinese and english databases, such as wanfang, weipu, cnki, pub med, cochrane library, and embase, the literature on the use of autologous fat fines graft in antiaging facial was collected, covering randomized comparative trials, nonrandomized comparative studies, comparative case studies, cohort studies, case reports, and so forth.Meta-analyses were also conducted on complication rates, beauty seeker satisfaction, and one-shot success rates.Results.This study included 23 studies that held metaelaborations, including a total of 2852 beauty seekers.According to metaelaboration, the complication rate was 0.02 (95% ci: 0.01, 0.04), the satisfaction rate of beauty seekers was 0.95 (95% ci: 0.91, 0.97), and the success rate of one injection is 0.79 (95% ci: 0.73, 0.84).Conclusion.Autologous fat fine-grain transplantation is obvious and stable in the use of antiaging facial, and it is necessary to popularize the use in clinical practice.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Meta-Analysis;
Tensiomyography and Statistical Analysis Based Muscle Change Detection in Multiple Sclerosis for Smart Healthcare

The impact of demyelinization on muscle fiber changes and the type of changes in multiple sclerosis (ms) is very hard to estimate.One of the major problems of ms patients is muscle fatigue and decrease of muscle force in the range of 16–57%.The objective of this research work is to estimate various aspects of muscle changes at tibial muscle (m ta) level using a noninvasive method named as tensiomyography (tmg).Tmg provides information about muscle functions in ms.This study includes 40 ms patients among which 18 are males (45%) and 22 are females (55%).They are divided in two subgroups: subgroup a and subgroup b.Subgroup a includes 20 ms patients without clinical decelable gait disorders and subgroup b includes 20 ms patients with clinical decelable gait disorders.Also, we have a control group that includes 20 healthy people with the same average age.Average age is 38.15 ± 11.19 y for ms patients and 39.34 ± 10.57 for healthy people.Evaluation measures include adl score and edss scale.The adl score is 0 for patients from subgroup a and 1 for patients from subgroup b.The edss score is 1 for subgroup a and 2.5 for subgroup b.This study confirms the importance of tmg based evaluation of muscle changes in ms patients.This smart healthcare system is also used for prediction of the muscle changes and muscle imbalance.Contraction time (tc) recordings are used to detect the muscle fatigue which is a specific symptom of ms.The value of tc for subgroup a is 45.8 ms and subgroup b is 61.37 ms for right side.Analysis of these two parameters such as dm and tc could define the muscle behaviour and help provide early information about the possibility of developing gait disorders.This smart tmg system analyses the muscle tone in the best possible way to predict the onset of any diseases which is an integral part of the smart healthcare system.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Significance of the Expression of TC and TG Levels in the Initial Diagnosis and Treatment of SCLC Patients and Their Tie-In with Prognosis

The article examines the expression of tc and tg levels in the initial diagnosis and treatment of sclc patients and their tie‐in with prognosis.Patients with sclc are included in the case set, who are initially treated in the tumor center of our hospital from january 2020 to january 2021 and are confirmed by histopathology or cytology as the research subjects.80 healthy volunteers are included in the control set, who received physical examination.All the enrolled patients received the first‐line standard treatment plan, and the clinical data of all sclc patients are inquired through the medical record file system of the hospital.At the initial diagnosis and treatment, the tg and tc levels of all patients and healthy persons are measured and recorded by blood biochemistry.For sclc patients, the risk factors affecting the prognosis of patients with progression‐free survival include newly diagnosed tc, tg levels, and tumor stage.Combined tc and tg detection can be used as indicators to predict the prognosis of the patients.Tc and tg are significantly correlated with the prognosis of the patients with progression‐free survival time.It is worthy of clinical application.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Sevoflurane Suppresses the Growth, Metastasis, and Invasion of Endometrial Carcinoma Cells via miR-195-5p/JAK2 Axis

Highly invasive and destructive endometrioma is one of the most familiar primary malignant tumors among women.It has been studied that sevoflurane can influence the development of various malignancies.But whatever sevoflurane could influence endometrial tumors is unknown.Materials and methods.Through cck8 and transwell analysis, we investigated the influence of sevoflurane on the development of endometrial tumors in vitro.Then, we studied the function of mi rna-195-5p to promote sevoflurane to inhibit the development of endometrial tumors.Then, we predicted the target genes of mi rna-195-5p by online software and focused on jak2.Through luciferase assay, we proved the direct binding and regulation of mi rna-195-5p to jak2.Results.We showed that sevoflurane could inhibit the growth, metastasis, and invasion of endometrial tumors via mi rna-195-5p/jak2 axis.Conclusions.Our research shows the function of sevoflurane in inhibiting the development of endometrial tumors via mi rna-195-5p/jak2 axis.Our findings proved that sevoflurane is potentially beneficial for endometrial carcinoma patients with surgery and may be helpful for the choice of anesthetics in endometrial carcinoma operations.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Serum KIM-1, NGAL, and NAG Levels and Correlation with the Diagnostic Value in Patients with Fracture Traumatic Shock

Traumatic shock is the most common cause of serious adverse outcomes in patients with severe traumatic diseases such as fractures, and some studies here have shown that the main cause of death from traumatic shock is the impairment of organ function that occurs after shock.In this study, we explored the role of serum kidney injury molecule-1 (kim-1), neutrophil gelatin-related lipid transporter protein (ngal), and n-acetyl-β-d-glucosidase (nag) levels in evaluating and diagnosing the condition of patients with fracture traumatic shock based on the goal of contributing to the clinical diagnosis of the patient’s condition as soon as possible and taking measures to alleviate its progress.96 patients with fracture traumatic shock were included in the study as the observation group and 58 healthy examiners as the control group, and the observation group was divided into 69 cases in the mild-moderate group and 27 cases in the severe group according to the acute physiology and chronic health status scale (apache-ii).In this study, we detected and analyzed the differences in serum kim-1, ngal, and nag levels between the observation group and the control group and the observation group with different disease levels.We found that the observation group was significantly higher than the control group, and the severe patients were higher than the mild to moderate patients, and we observed that serum kim-1, ngal, and nag are significantly correlated with the condition of patients with fracture traumatic shock after further analysis using the pearson model.In addition, the diagnostic value of receiver operating characteristic curve analysis showed that the auc of serum kim-1 for the diagnosis of fracture traumatic shock was 0.755, the auc of serum ngal was 0.750, the auc of serum nag was 0.772, and the auc of the combination of the three indicators was 0.915.The results of this study thus suggest the possibility of serum kim-1, ngal, and nag as clinical indicators for evaluating the condition of patients with fracture traumatic shock and the possibility of a combined test of serum kim-1, ngal, and nag for diagnosing the condition.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Research Article;
Safety and Efficacy of Unicondylar Knee Prosthesis Treatment for Unicompartmental Osteoarthritis of the Knee Joint

Knee osteoarthritis (koa) is a chronic disease that seriously endangers the health of the elderly.Choosing appropriate surgery for knee osteoarthritis patients is especially important.Objective.To investigate the safety and efficacy of unicondylar knee prosthesis treatment for unicompartmental osteoarthritis of the knee.Materials and methods.One hundred patients with unicondylar osteoarthritis of the knee treated in our hospital from june 2019 to june 2021 were selected as retrospective study subjects and were divided into 50 cases each in the comparison group and the observation group according to the different surgical methods.Among them, the comparison group was treated with unicondylar knee arthroplasty (uka), and the observation group was treated with unicondylar knee prosthesis replacement, and the differences in aks score, knee flexion angle, tibial angle orthosis, joint mobility, and postoperative recovery were compared between the two groups.Results.The aks score and knee flexion angle score of the observation group were higher than those of the comparison group after surgery.However, the tibial angle orthopedic score of the observation group was significantly lower than that of the comparison group after surgery for comparison, and the vas score of the observation group was lower than that of the comparison group.However, the lysholm score of the observation group was higher than that of the control group after surgery ( p &lt; 0.05 ).The complication rate of patients in the observation group was significantly lower than that of the comparison group, and the hss score, vas score, and knee mobility (rom) of the two groups were statistically significant ( p &lt; 0.05 ) when compared at 7 d after surgery and 6 months after surgery.Conclusion.The clinical efficacy of unicondylar knee prosthesis replacement for osteoarthritis of the knee is better than that of unicondylar knee arthroplasty (uka) treatment.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Role of miR-181b/Notch1 Axis in circ_TNPO1 Promotion of Proliferation and Migration of Atherosclerotic Vascular Smooth Muscle Cells

The role and expression level change in circ_tnpo1 (hsa_circ_0072951) in atherosclerosis (as) and vsmc dysfunction remain unknown.In this study, we try to explore the effects of circ_tnpo1 on oxidized low-density lipoprotein (ox-ldl)-induced human vascular smooth muscle cell (vsmc) excessive proliferation and migration, and the potential molecular mechanism.Methods.Quantitative real-time polymerase chain reaction (rt-q pcr) and western blot experiment were used to detect the serum samples from as patients and healthy controls.Cck-8, transwell, and the dual-luciferase reporter gene assay were used to detect the cell biology.Results.In human as serum and ox-ldl-induced vsmcs, circ_tnpo1 was increased, whereas mi r-181b was decreased.Silencing circ_tnpo1 inhibited proliferation and migration activity and reduced protein expression of pcna, ki-67, mmp2, and e-cadherin and promoted n-cadherin protein expression in ox-ldl induced vsmcs.Remarkably, mi r-181b knockdown or notch1 overexpression could efficiently offset the proliferation and migration inhibiting effect of circ_tnpo1 knockdown in ox-ldl-induced vsmcs.Furthermore, a molecular mechanism study pointed out that circ_tnpo1 and notch1 are direct-acting targets of mi r-181b.Conclusions.In conclusion, our study indicated that circ_tnpo1 promotes the proliferation and migration progression of vsmcs in atherosclerosis through the mi r-181b/notch1 axis.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Role and Mechanism of circ_0058063/miR-635 Axis in the Malignant Phenotype of Multiple Myeloma RPMI8226 Cells

This study aims to explore circ_0058063 effect on multiple myeloma cells malignant phenotype and its feasible mechanism.Methods.We selected 47 cases of multiple myeloma tissues and 47 cases of normal bone marrow tissues and then used rt-q pcr method to test circ_0058063 and mi r-635 expression in the tissues.Myeloma cells rpmi8226 were transfected with si-circ_0058063, mi r-635 mimic, and si-circ_0058063 + anti-mi r-635, respectively.Then, we adopt cck-8 method, flow cytometry method, and transwell and western blot methods to detect the influences of knockdown of circ_0058063 or mi r-635 overexpression on rpmi8226 cell proliferation, apoptosis, migration, and invasion and also ki-67, bax, bcl-2, mmp-2, and mmp-9 protein expression.The dual luciferase reporter gene assay experiment proved that it has regulatory relationship between circ_0058063 and mi r-635.Results.Circ_0058063 expression of multiple myeloma was higher than that in normal bone marrow tissue ( p &lt; 0.05 ), while mi r-635 expression was lower than that in normal bone marrow tissue ( p &lt; 0.05 ).Knockdown of circ_0058063 or overexpression of mi r-635 could reduce proliferation capacity, migration, invasion cell quantities, and ki-67, mmp-2, mmp-9, and bcl-2 protein expression ( p &lt; 0.05 ), while increasing apoptosis rate together with bax protein expression ( p &lt; 0.05 ).Circ_0058063 targets to negatively regulate mi r-635, while knocking down mi r-635 reverses the influences of knocking down circ_0058063 on rpmi8226 proliferation, apoptosis, migration, and invasion.Conclusion.Circ_0058063 expression increased in multiple myeloma tissues.Knocking down its expression may inhibit myeloma proliferation, migration, and invasion by targeting and upregulating mi r-635 and also promote cell apoptosis.As for multiple myeloma treatment, circ_0058063/mi r-635 may provide new molecular targets.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Clinical Study;
Risk Factors of Acute Radiation-Induced Lung Injury Induced by Radiotherapy for Esophageal Cancer

To investigate the risk factors of acute radiation-induced lung injury (acute rili) induced by radiotherapy for esophageal cancer.Methods.A total of 206 patients with esophageal cancer who received radiotherapy in our hospital from january 2017 to march 2020 were selected.The general data such as gender, age, and comorbidities of the patients were collected, as well as the levels of cytokines (tnf-α, tnf-β, and il-6) in peripheral blood before radiotherapy; radiotherapy dose-related parameters were recorded during radiotherapy.Follow-up was 12 months after radiotherapy.The patients with induced acute rili after radiotherapy were set as the observation group ( n = 75 ).Patients without acute rili after radiotherapy were set as the control group ( n = 131 ).Univariate and multivariate logistic regression analysis was performed on the risk factors of acute rili induced by radiotherapy for esophageal cancer.Results.Univariate analysis and multivariate logistic regression analysis showed that the combined diabetes, total radiation dose, combined lung disease, physical factors (v30, dmean), and preradiotherapy cytokine (tnf-α, tnf-β, and il-6) elevated level was an independent risk factor for radiotherapy-induced acute rili in esophageal cancer ( p &lt; 0.05 ).conclusion.Concomitant diabetes, total radiation dose, lung disease, physical factors (v30, dmean), and levels of cytokines (tnf-α, tnf-β, and il-6) before radiation therapy are risk factors for acute rili induced by radiation therapy in esophageal cancer.The possibility of acute rili should be comprehensively assessed according to the patient’s condition, and the radiotherapy regimen should be adjusted to reduce and avoid the induction of acute radiation-induced lung injury.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Relationship between Different Degrees of Compression and Clinical Symptoms in Patients with Myocardial Bridge and the Risk Factors of Proximal Atherosclerosis

To explore the relationship between different degrees of compression and clinical symptoms in patients with the myocardial bridge and the risk factors of proximal atherosclerosis.Methods.The clinical data of 156 patients with the myocardial bridge who underwent selective coronary angiography in our hospital from december 2010 to december 2015 were collected.The patients were divided into noble grade i group (102 cases) and noble grades ii-iii group (54 cases) according to the degree of mural coronary artery systolic stenosis.According to the results of coronary angiography, 156 patients with the myocardial bridge were divided into an atherosclerosis group (the myocardial bridge combined with atherosclerosis at the proximal end of the myocardial bridge of simple wall coronary artery), 91 cases, and a control group (isolated myocardial bridge), 65 cases.The relationship between different degrees of compression and clinical symptoms in patients with the myocardial bridge was observed, and the logistic regression model was used to analyze the risk factors of proximal atherosclerosis in patients with the myocardial bridge.Results.The incidence of atherosclerotic stenosis, angina pectoris, and myocardial infarction in the proximal part of the myocardial bridge in the noble grades ii-iii group was higher than that in the noble grade i group ( p &lt; 0.05 ).The differences in age, hypertension, and noble classification between the two groups were statistically significant ( p &lt; 0.05 ).The differences of total cholesterol (tc) and c-reactive protein (crp) between the two groups were statistically significant ( p &lt; 0.05 ).Multivariate analysis showed that age, hypertension, noble grade, and crp were all risk factors for proximal atherosclerosis in patients with the myocardial bridge ( p &lt; 0.05 ).Conclusion.The more severe the compression of the myocardial bridge, the greater the risk of cardiovascular events for patients and the higher the incidence of atherosclerotic stenosis in the proximal part of the myocardial bridge.In addition, the occurrence of atherosclerosis in the proximal coronary artery of the myocardial bridge may be affected by age, hypertension, noble grade, and crp level.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Research Article;