syedzayyan/paper_mill_benchmark huggingface dataset:
Spinal Dural Arteriovenous Fistula: A Mimic of Demyelinating Disease and Radiculopathy.

Spinal dural arteriovenous fistula (sdavf) is characterized by an abnormal connection between a radicular artery and the venous plexus producing spinal cord venous congestion.It manifests with nonspecific sensory and motor symptoms.We present three cases of sdavf with different forms of presentation; in two cases, an autoimmune etiology was considered, and in the third case, the initial diagnosis was chronic radiculopathy.In all three cases, a serpentine enhancement was observed after the gadolinium in the dorsal region of the spinal cord corresponded to flow voids in t2-weighted images, which guided the diagnosis.Sdavf should be considered in atypical clinical presentations of radiculopathies or spinal cord syndromes, especially spinal conus or epicone syndrome.Likewise, it should be part of the differential diagnosis of spinal cord presentations of demyelinating diseases such as multiple sclerosis or neuromyelitis optica spectrum disorders.

Journal: Cureus (2022)
Publication types: Case Reports;Journal Article
Learning practical nursing skills in simulation centers - A narrative review.

Practical skills are complex procedures integrating communication and caring, as well as technical and manual aspects.Simulation at a simulation/skills center offers a wide range of learning activities and aims to imitate patient situations.Objectives to investigate the international research literature on practical skills learning in simulation/skills centers in nursing education.Research questions: 1.What are the range and type of practical skills studied?2.What learning activities are focused on in the studies included in the review?3.What are the learning outcomes and how are they assessed?Design narrative review.Methods we searched electronically and included studies from medline ovid, cinahl, eric, embase, academic search premiere, and cochrane.Unique indexing terms and search strategies were developed for each database.The criteria for inclusion were bachelor nursing students as the study population and practical nursing skills learning in simulation/skills centers.We used rayyan qcrit for the initial screening and the mixed method appraisal tool for quality assessment.We used a narrative approach to synthesize the diverse range of studies.Findings one hundred and twenty-one studies from 26 countries published between january 2013 and march 2022 were included.The amount of quantitative research was overwhelming (n= 108).A total of 50 different practical skills were represented.The studies focused on which learning modalities resulted in the best learning outcomes.Only 8.5% (n= 7) of the included studies concerned students' learning processes.Skill performance (n= 101), knowledge (n= 57), confidence (n= 34), and satisfaction (n= 32) were the main learning outcomes measured.Discussion the quality assessment indicated that 10 of the studies achieved 100% on the mixed method appraisal tool criteria.In many of the studies with quasi-experimental and randomized controlled trial designs, the intervention group received some form of educational treatment while the control group received no treatment.The choice of no treatment for the control group in pedagogical research seems to disregard the inherent purpose and effect of teaching and learning.Conclusion heterogeneity in the use of learning modalities and measuring instruments precludes the possibility of building on other research.Technical skills were the preferred choice of skill, while skills that involved a fair measure of communication and collaboration were only sparingly studied.Students' learning processes were barely touched on in the included studies.More focus should be placed on this area in further research, since the choice of learning modalities may affect the students' learning processes in significant ways.

Journal: International journal of nursing studies advances (2022)
Publication types: Journal Article;Review
People with Dementia in Sub-Saharan Africa: From Support to Abuse by Caregivers: Results of EPIDEMCA-FU Program in Congo.

Dementia is an emerging public health problem in sub-saharan africa (ssa).In ssa, the stigma suffered by people with dementia (pwd) can be strongly linked to pejorative social representations, interfering in social relationships with informal caregivers.The objective of the study was to analyze the consequences of social representations of pwd in social interactions with informal caregivers.Methods a qualitative study was conducted in republic of congo among 93 interviewees.Nondirectional interviews were conducted in local languages and complemented by participating observations.The collected data were transcribed literally, synthesized, and then coded to allow extraction and organization of text segments.Results informal caregivers, daughters-in-laws, were considered as abusers and granddaughters as benevolent.The leaders of syncretic churches and traditional healers were the first therapeutic itineraries of pwd, due to pejorative social representations of disease.Of these, some pwd have appeared at front of a customary jurisdiction for accusations of witchcraft.Dementia, perceived as a mysterious disease by informal caregivers, wasn't medicalized by leaders of syncretic churches, traditional healers, nurses, or general practitioners.Conclusion: stigma, generated by social representations, can change the patient's behavior and the one of informal caregivers, leading to time delay in the search for appropriate help.

Journal: Dementia and geriatric cognitive disorders extra (2019)
Publication types: Journal Article
Search for Novel Potent Inhibitors of the SARS-CoV-2 Papain-like Enzyme: A Computational Biochemistry Approach.

The rapid emergence and spread of new variants of coronavirus type 2, as well as the emergence of zoonotic viruses, highlights the need for methodologies that contribute to the search for new pharmacological treatments.In the present work, we searched for new sars-co v-2 papain-like protease inhibitors in the pub chem database, which has more than 100 million compounds.Based on the ligand efficacy index obtained by molecular docking, 500 compounds with higher affinity than another experimentally tested inhibitor were selected.Finally, the seven compounds with adme parameters within the acceptable range for such a drug were selected.Next, molecular dynamics simulation studies at 200 ns, δg calculations using molecular mechanics with generalized born and surface solvation, and quantum mechanical calculations were performed with the selected compounds.Using this in silico protocol, seven papain-like protease inhibitors are proposed: three compounds with similar free energy (d28, d04, and d59) and three compounds with higher binding free energy (d60, d99, and d06) than the experimentally tested inhibitor, plus one compound (d24) that could bind to the ubiquitin-binding region and reduce the effect on the host immune system.The proposed compounds could be used in in vitro assays, and the described protocol could be used for smart drug design.

Journal: Pharmaceuticals (Basel, Switzerland) (2022)
Publication types: Journal Article
Traumatic atlantoaxial anteroinferior subluxation with dens and Hangman fractures: A case report.

Rationale traumatic atlantoaxial anteroinferior subluxation associated with a dens fracture and a hangman fracture is a very rare and complex injury.Therefore, appropriate surgical strategy is not established.Patient concerns an 85-year-old female presented with posterior neck pain and atypical neck position caused after rolling down a hill.Although neurological examinations for motor, sensory, gait, and reflex tests were normal, the patient complained of an abnormal neck posture.Diagnoses radiological examinations revealed an atlantoaxial anteroinferior subluxation with kyphosis, a type iia dens fracture (anderson and d'alonzo classification) with an anterolateral rotatory angulation of type iia dens fracture fragment, and a type i hangman fracture (levine and edwards classification).Nevertheless, the transverse atlantal ligament was intact.Interventions we considered that the intact transverse atlantal ligament and kinking of the type iia dens fracture fragment into the left lateral mass of c1 prevented a spinal cord injury by blocking a further displacement of c1 to c2.Due to the patient's osteoporosis and the anterolateral rotatory angulated type iia dens fracture fragment, a forceful reduction of the atlantoaxial anteroinferior subluxation with kyphosis could pose a high risk of fixation failure and spinal cord injury.Therefore, we performed in-situ posterior c1-2 fusion using a c1 lateral mass screw and c2 lamina screw fixations.Outcomes at 1 year after surgery, the bone union of all fractures was achieved in the kyphosis state.Furthermore, the patient's clinical symptoms were improved with no neurological deficit.Lessons a thorough radiological examination and appropriate surgical strategy are important for successful diagnosis and treatment of a complex c1-2 injury.

Journal: Medicine (2021)
Publication types: Case Reports;Journal Article
A pragmatic evaluation of a public health knowledge broker mentoring education program: a convergent mixed methods study.

Public health professionals are expected to use the best available research and contextual evidence to inform decision-making.The national collaborating centre for methods and tools developed, implemented, and evaluated a knowledge broker mentoring program aimed at facilitating organization-wide evidence-informed decision-making in ten public health units in ontario, canada.The purpose of this study was to pragmatically assess the impact of the program.Methods a convergent mixed methods design was used to interpret quantitative results in the context of the qualitative findings.A goal-setting exercise was conducted with senior leadership in each organization prior to implementing the program.Achievement of goals was quantified through deductive coding of post-program interviews with participants and management.Interviews analyzed inductively to qualitatively explain progress toward identified goals and identify key factors related to implementation of eidm within the organization.Results organizations met their goals for evidence use to varying degrees.The key themes identified that support an organizational shift to eidm include definitive plans for participants to share knowledge during and after program completion, embedding evidence into decision-making processes, and supportive leadership with organizational investment of time and resources.The location, setting, or size of health units was not associated with attainment of eidm goals; small, rural health units were not at a disadvantage compared to larger, urban health units.Conclusions the knowledge broker mentoring program allowed participants to share their learning and support change at their health units.When paired with organizational supports such as supportive leadership and resource investment, this program holds promise as an innovative knowledge translation strategy for organization wide eidm among public health organizations.

Journal: Implementation science communications (2022)
Publication types: Journal Article
Optimization of submerged fermentation of Thelephora ganbajun zang.

The effects of the fermentation conditions on both the biomass yield and the organic selenium yield of thelephora ganbajun zang were studied.The components most suitable for the submerged fermentation medium were examined using the orthogonal array method; they comprised sucrose at 30 g l(-1) , carbamide 1 g l(-1) , corn steep liquor 8 g l(-1) , mg so4 ·7h2 o 0.3 g l(-1) , kh2 po4 0.5 g l(-1) , and na cl 5 g l(-1) .The optimum cultivation conditions that resulted in maximal biomass yield were obtained using the response surface methodology (rsm).The conditions were as follows: initial p h, 5.84; temperature, 26.16 °c; and rotation speed, 170 rpm.Feeding sucrose led to a higher biomass yield, with a maximum of 21.20 g l(-1) .The biomass yield and the organic se yield of t.Ganbajun could reach 10.8 g l(-1) and 3256.07 mg kg(-1) , respectively, in a culture medium supplemented with 200 mg l(-1) sodium selenite (na2 se o3 ), which was added to the medium at 36 h after inoculation.Application of the orthogonal array method and rsm gave rise to a significant enhancement in the biomass yield of t.Ganbajun.The results of these experiments indicate that t.Ganbajun is a promising microorganism for selenium enrichment.

Journal: Journal of basic microbiology (2014)
Publication types: Journal Article
Indocyanine green as a new trend in sentinel lymphatic node detection in oncogynecology.

In oncological surgery the importance of the sentinel node concept is increasing, as we are capable of reducing the surgical burden of patients and its associated morbidity and preserving adequate oncological safety at the same time.Recently, there has been development of lymph node mapping techniques, where the most promising method appears to be the immunofluorescent one using indocyanine green dye.This technique provides high sensitivity in sentinel node detection in comparison with other existing methods using a dye in combination with a radionuclide.The indocyanine green technique has several advantages, and at the same time, we can use this method in non-oncological indications in gynecological surgery.

Journal: Ceska gynekologie (2022)
Publication types: Journal Article
IgE Mediated Wheat Allergy Associated with Resistant and Severe Forms of Allergic Conjunctivitis.

This study aimed to determine the prevalence and criteria of wheat allergy (wa) among patients with resistant allergic conjunctivitis (ac).Methods a prospective comparative study was conducted on 100 patients with resistant ac.Skin prick-tests (spts), total and s ig e against a panel of inhalant and food allergens were performed in all patients' sera.They were divided into 2 groups according to skin prick test (spt) and specific ig e (s ig e) level, namely the wheat sensitive group (wsg) and wheat tolerant group (wtg).Total ocular symptom scores (toss) and 4-point sign scales were correlated for both groups.Results ten patients out of 100 with ig e-mediated resistant ac were wheat sensitive, and the other 90 were wheat tolerant patients.Wsg included patients of significantly younger age.Positive family history of atopy was proven in100% of wsg vs.67% of wtg.A significantly higher frequency of multiorgan allergy was detected in 100% of wsg vs.20% in wtg (p= 0.0001).Thirty (30%) of wsg had associated allergic rhinitis (ar) and bronchial asthma (ba).Another 30% had an associated ar only, 10% had an associated ba only, and another 20% had an associated skin allergy.Toss, 4- point sign scale, and total ig e level were significantly higher in wsg.Conclusion this study provides novel evidence that wheat allergy is responsible for some severe forms of ac.

Journal: The open respiratory medicine journal (2022)
Publication types: Journal Article
Activation of Receptor Tyrosine Kinases Mediates Acquired Resistance to MEK Inhibition in Malignant Peripheral Nerve Sheath Tumors.

Malignant peripheral nerve sheath tumors often arise in patients with neurofibromatosis type 1 and are among the most treatment-refractory types of sarcoma.Overall survival in patients with relapsed disease remains poor, and thus novel therapeutic approaches are needed.Nf1 is essential for negative regulation of ras activity and is altered in about 90% of malignant peripheral nerve sheath tumors (mpnst).A complex interplay of upstream signaling and parallel ras-driven pathways characterizes nf1-driven tumorigenesis, and inhibiting more than one ras effector pathway is therefore necessary.To devise potential combination therapeutic strategies, we identified actionable alterations in signaling that underlie adaptive and acquired resistance to mek inhibitor (meki).Using a series of proteomic, biochemical, and genetic approaches in anin vitromodel of meki resistance provided a rationale for combination therapies.Hgf/met signaling was elevated in the meki-resistant model.Hgf overexpression conferred resistance to meki in parental cells.Depletion of hgf or met restored sensitivity of meki-resistant cells to meki.Finally, a combination of mek and met inhibition demonstrated activity in models of mpnst and may therefore be effective in patients with mpnst harboring genetic alterations in nf1.Significance: this study demonstrates that meki plus met inhibitor may delay or prevent a novel mechanism of acquired meki resistance, with clinical implications for mpnst patients harboring nf1alterations.

Journal: Cancer research (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Ab initio QED Treatment of the Two-Photon Annihilation of Positrons with Bound Electrons.

The process of a positron-bound-electron annihilation with simultaneous emission of two photons is investigated theoretically.A fully relativistic formalism based on an ab initio qed description of the process is worked out.The developed approach is applied to evaluate the annihilation of a positron with k-shell electrons of a silver atom, for which a strong contradiction between theory and experiment was previously stated.The results obtained here resolve this longstanding disagreement and, moreover, demonstrate a sizable difference with approaches so far used for calculations of the positron-bound-electron annihilation process, namely, lee's and the impulse approximations.

Journal: Physical review letters (2019)
Publication types: Journal Article
Long noncoding RNA LINC00324 exerts protumorigenic effects on liver cancer stem cells by upregulating fas ligand via PU box binding protein.

Hepatocellular carcinoma (hcc) represents a major cause of cancer death, but the molecular mechanism for its development has not yet been well characterized.Long noncoding rnas (lnc rnas) are involved in a wide range of biological processes via their roles as oncogenes or tumor suppressor genes.The present study aimed to elucidate the role of linc00324 in hcc through its interaction with fas ligand (fas l).Initially, microarray-based gene expression profiling of hcc was employed to identify differentially expressed genes.Next, the expression of linc00324 in hcc tissues and liver cancer stem cell (lcsc) lines was examined using rt-q pcr.Then, the interaction among linc00324, pu box binding protein (pu.1) and fas l was identified with rip, ch ip and dual-luciferase reporter gene assays.The effect of linc00324 on viability, proliferation, migration, invasion, and apoptosis as well as the tumorigenesis of transfected cells was examined with gain- and loss-of-function experiments.Linc00324 and fas l were highly expressed in hcc.Linc00324 regulated fas l expression via interaction with pu.1.Silencing of linc00324 or fas l suppressed expression of stemness-related genes, cell viability, proliferation, migration, invasion, self-renewal, and tumorigenesis, but enhanced cell apoptosis.Taken together, linc00324 promotes the expression of fas l through the recruitment of pu.1, which ultimately maintains the biological properties of lcscs, thus, highlighting linc00324 as a promising therapeutic candidate for hcc.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Reduced Fat Taste Sensitivity in Obese Japanese Patients and Its Recovery after a Short-Term Weight Loss Program.

Fat taste has recently attracted attention as the 'sixth taste.' however, the relationship between fat and sweet taste in japanese obesity has not yet been examined, and no reports have ascertained whether improvement of fat taste can be obtained by weight loss.Patients were recruited into obesity group (bmi≥30 kg/m2; n=15) or control group (bmi<25 kg/m2; n=11).They answered a questionnaire on smoking, eating behavior, lifestyle, and food frequency, and their taste thresholds were measured (fat, umami, and sweet).The obesity group was tested twice (on admission and before discharge).They showed several eating behavior abnormalities, higher total energy intake, and less physical activity.There were some gender differences: physical inactivity was more prominent in females, and high total energy intake in males, which correlates with fat taste rank.Fat taste rank was significantly higher in obesity group, whereas taste rank of umami and sweet were not significantly different.Gender-specific analysis of fat taste rank revealed only male obesity showed significant difference.Reduced sensitivity of fat may be specific to male gender or obesity by overeating, but not by physical inactivity.Multiple logistic regression analysis revealed that fat taste was a factor relevant to obesity.Fat taste significantly improved after a weight loss program, with average duration of 11.3 d.Japanese obese people, especially males and those who are obese by overeating, have reduced sensitivity to fat taste.This can be recovered by even a short-term weight loss program.

Journal: Journal of nutritional science and vitaminology (2022)
Publication types: Journal Article
Simulations as a mode of clinical training in healthcare professions: A scoping review to guide planning in speech-language pathology and audiology during the COVID-19 pandemic and beyond.

Simulation plays an important role as an alternative method for training of students, particularly in health education.As a result of coronavirus disease 2019 (covid-19) restrictions of face-to-face interactions, traditional teaching methods have been disrupted, increasing the need for alternative methods to supplement modes of student clinical training in healthcare programmes.Objectives the scoping review aimed to determine what has been documented about simulation as a mode of clinical training in healthcare professions (hcps) in order to guide speech-language pathology and audiology (slpa) professions during the covid-19 pandemic and beyond.Method a scoping review was conducted.Electronic bibliographic databases including science direct, pub med, scopus medline, pro quest, google scholar and world cat were searched to identify peer reviewed publications, published in english, between january 2011 and december 2021, and related to the use of simulation in hcps clinical training programmes.Results a total of 32 articles met the inclusion criteria for this scoping review.Three themes emerged when reviewing the studies: (1) face-to-face simulations as a mode of clinical training, (2) virtual reality simulation and telesimulation as modes of clinical training and (3) simulation as a complementary mode of clinical training.Evidence suggests that whilst simulations are cost-effective, accessible and efficacious as clinical training modes, they need to be combined with other modes of training such as the traditional clinical training to yield better learning outcomes.Conclusions current findings highlight the role and value of simulation as a clinical training mode during covid-19 and beyond.However, there are aspects that need to be considered to ensure that this mode of clinical training is effective, with endorsement and regulations by the slpa professional board of the health professions council of south africa (hpcsa).Simulations need to be complemented with traditional clinical training methods.In the context of slpa, particularly in low- and middle-income countries (lmics), simulation can be used to better prepare students for their clinical placement where clinical training platforms are limited and where simulation combined with teletraining or telesupervision can be utilised to increase access to training.

Journal: The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings (2022)
Publication types: Journal Article;Review