syedzayyan/paper_mill_benchmark huggingface dataset:
The association of hourly second-stage documentation with cesarean delivery and maternal blood loss.

Of the article cesarean rates and maternal morbidity increase with the duration of the second stage of labor.We studied the effect of hourly evaluation and documentation during the second stage of labor on maternal and fetal outcomes.Materials and methods we performed a retrospective cohort study of all women who delivered at our urban, tertiary care hospital and underwent a second stage of greater than 60 min between 1 june 2016 and 31 may 2019.There were 1498 patients with complete data.Four hundred forty patients had hourly evaluation and documentation throughout the second stage and 1058 did not.We performedt-tests, chi-squared, and regression analyses to compare cesarean delivery rate, second-stage duration, quantitative blood loss, hemorrhage and blood transfusion rates, and fetal outcomes.We performed regression analyses to evaluate for independent effect of this intervention on each outcome.Results patients with hourly evaluation and documentation had a decreased likelihood of cesarean delivery (8.2% vs.20.3%,p< .001), shorter second-stage of labor (98.1 min vs.177.5 min,p< .001), decreased quantitative blood loss (514.4 m l vs.667.7 m l,p< .001), and hemorrhage rate (12.5% vs.19.9%,p< .001).Hourly evaluation was associated with decreased transfusion rates (3.2% vs.5.6%,p= .05) but was not related to the number of units transfused.Regression analyses confirmed the impact of hourly documentation when potential confounders were included.These differences in outcomes were also noted when evaluation was performed and documented within every 75 min.Hourly second-stage evaluation and documentation did not affect other maternal or infant morbidities.Conclusion hourly evaluation and documentation in the second stage was associated with decreased cesarean delivery rate, second-stage duration, quantitative blood loss, hemorrhage, and transfusion.

Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2022)
Publication types: Journal Article
Association between Periodontitis and Pulp Calcifications: Radiological Study.

The presence of intrapulpal calcifications is one of the effects reported as a consequence of periodontal pathology.Although the impact of the pulp pathology on the periodontium is obvious, the contrary remains unclear and controversial.This study was conducted in order to better understand this fact and establish a potential association between periodontitis and intrapulpal calcifications and then to determine the factors associated with their occurrence.Materials and methods to investigate the issue, a retrospective radiological study using periapical preoperative radiographics assessed 332 teeth taken from the records of 79 patients who received treatment for periodontitis.In the second part of the study, 81 of the sample with intact dental crowns presenting an attachment loss were compared to their contralateral with intact dental crowns without any attachment loss.The study of the association between periodontitis and intrapulpal calcifications and the factors associated with their occurrence was performed by the chi squared and fisher's exact tests.The significance level was set at 0.05.Results the results indicated that 251 (75.6%) teeth had an attachment loss while 102 (30.7%) had intrapulpal calcification.Among the 206 (62%) teeth with intact crown, only 6 (1.8%) showed calcification in the pulp cavity and 20 (6%) showed calcification in the root canals, with a statistically significant difference (p< 0.005) compared to teeth with restorations and caries.For the 32 (19.7%) teeth with coronary calcification, 18 (22.2%) presented an attachment loss versus 14 (17.2%) without attachment loss; the difference was not statistically significant (p=0.6).Similarly, only 13 (16%) of a total of 22 (13.5%) teeth with root canal calcification had attachment loss versus 9 (11.1%) without attachment loss.This difference was not statistically significant (p=0.5).Conclusion this radiographic study revealed no association between the presence of periodontitis and the occurrence of intrapulpal calcifications.Although intrapulpal calcifications were present in some teeth with loss of attachment, they were not necessarily the consequence of periodontal disease.

Journal: International journal of dentistry (2022)
Publication types: Journal Article
Human recombinant FSH induces chemoresistance in human breast cancer cells via HIF-1α activation†.

Breast cancer patients under 40 years of age who are candidate to chemotherapy with alkylating drugs may undergo controlled ovarian stimulation (cos) with recombinant human follicle-stimulating hormone (rh fsh) in order to get fertility preservation by mature oocyte cryostorage.The direct effect(s) of exogenous rh fsh on the chemosensitivity of breast cancer is currently unknown.To clarify this issue, we incubated four different breast cancer cell lines with rh fsh (10 iu/l, 24 h) and then we exposed them to doxorubicin (dox) or cyclophosphamide (cpa).The effect(s) of rh fsh on human breast cancer cells treated with dox or cpa was measured in terms of (1) cell viability, (2) cytotoxicity, (3) multidrug resistance (mdr) genes and proteins expression and activities, and (4) hypoxia-inducible factor 1-alpha (hif-1α) activation.Pretreatment with rh fsh significantly increased the viability of breast cancer cells after treatment with dox or cpa, and reduced the lactate dehydrogenase leakage and reactive oxygen species production.Moreover, after preincubation with rh fsh, the mdr proteins (pgp, mpr1, and bcrp) expression and activity resulted upregulated and the hif-1α pathway activated.In addition, the use of a widely used hif-1α inhibitor, the 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (yc-1), prevented the rh fsh effect on the onset of mdr.Taken together, these observations suggest that a short exposure to rh fsh induces chemoresistance to dox and cpa in human breast cancer cells via hif-1α activation.

Journal: Biology of reproduction (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Studying the Influence of Silica Fume on Bond Strength of the PCM-Concrete Interface under Shear Stress Condition.

The polymer cement mortar (pcm) overlay method is a promising solution for strengthening deteriorated concrete structures in which the occurrence of premature debonding at the interfaces prevents the strengthened structures from achieving full serviceability.The purpose of this study is to improve the concrete-pcm interfacial bond to prevent premature debonding.There are two main focuses of this study: (i) investigation of the effectiveness of adding 5% silica fume to pcm in forming a chemical connection between concrete and pcm, based on a direct single-surface shear test using two roughness levels of concrete (smooth and rough) and microstructure analysis and (ii) performance evaluation of the bond between substrate concrete and a pcm overlay with/without silica fume at early ages and with different moisture conditions at the interface, based on a bi-surface shear test using rough substrate concrete surface.The inclusion of 5% silica fume with pcm caused an improvement in the interfacial strength (approximately 113% relative to the normal pcm in cases of without primer), with a smooth concrete substrate surface where mechanical bonding had less influence.In addition, lower ca/si values in the interface of modified 5% silica pcm specimens compared to the normal pcm specimens quantified by energy-dispersive x-ray spectroscopy (eds) indicate the formation of a chemical connection at the concrete-pcm interface by transforming harmful ca(oh)2into more c-s-h which strongly improves the bonding strength.As a repair layer mortar, the positive influence of silica fume in modified 5% silica pcm specimens was also found at early ages and with different moisture conditions at the interface compared to the normal pcm.In conclusion, the addition of silica fume to the pcm caused chemical connection at the concrete-pcm interface and improved the interfacial performance.

Journal: Materials (Basel, Switzerland) (2022)
Publication types: Journal Article
Antibacterial Application onStaphylococcus aureusUsing Antibiotic Agent/Zinc Oxide Nanorod Arrays/Polyethylethylketone Composite Samples.

In this study, zinc oxide (zn o) nanorod arrays as antibiotic agent carriers were grown on polyetheretherketone (peek) substrates using a chemical synthesis method.With the concentration of ammonium hydroxide in the precursor solution kept at 4 m, zn o nanorod arrays with diameters in the range of 100-400 nm and a loading density of 1.7 mg/cm2were grown onto the peek substrates.Their drug release profiles and the antibacterial properties of the antibiotic agent/zn o/peek samples in the buffer solution were investigated.The results showed that the concentrations of antibiotic agents (ampicillin or vancomycin) released from the samples into the buffer solution were higher than the value of minimum inhibitory concentration of 90% for staphylococcus aureuswithin the 96 h test.The bioactivities of ampicillin and vancomycin on substrates also showed around 40% and 80% on the staphylococcus aureus, respectively.In the antibacterial activity test, sample with the suitable loading amount of antibiotic agent had a good inhibitory effect on the growth of staphylococcus aureus.

Journal: Nanomaterials (Basel, Switzerland) (2019)
Publication types: Journal Article
Intravascular Lithotripsy for Underexpanded Stent in Heavily Calcified Coronary Artery Disease.

Can intravascular lithotripsy safely modify calcium in an underexpanded stent and result in optimal expansion and improved outcome?Coronary artery calcification results in difficulty with stent delivery and expansion and is associated with adverse outcomes.Intravascular lithotripsy (ivl) by delivering acoustic pressure waves modifies calcium plaque that improve vessel compliance resulting in optimizing stent deployment.Results a 63-year-old patient presented with acute coronary syndrome with symptoms of unstable angina who underwent angiography that showed calcified right coronary artery which was treated with balloon angioplasty and stenting with drug eluting stent.However, after multiple inflations with noncompliant balloon, the patient was noted to have persistent residual in stent stenosis of 70%.Stenotic lesion in poorly expanded stent was treated with shockwave c2 coronary intravascular lithotripsy catheter resulting in 0% residual stenosis.The patient was followed for major adverse cardiovascular events at 30 days and 12 months.The patient remained mace free at 30 days and 12 months.Conclusions coronary ivl safely and effectively facilitated stent expansion in severely calcified lesion in a poorly expanded stent with mace free at 12-month follow-up.

Journal: Case reports in cardiology (2022)
Publication types: Case Reports;Journal Article
Radiomics-Based Predictive Model of Radiation-Induced Liver Disease in Hepatocellular Carcinoma Patients Receiving Stereo-Tactic Body Radiotherapy.

(1) background: the application of stereotactic body radiation therapy (sbrt) in hepatocellular carcinoma (hcc) limited the risk of the radiation-induced liver disease (rild) and we aimed to predict the occurrence of rild more accurately.(2) methods: 86 hcc patients were enrolled.We identified key predictive factors from clinical, radiomic, and dose-volumetric parameters using a multivariate analysis, sequential forward selection (sfs), and a k-nearest neighbor (knn) algorithm.We developed a predictive model for rild based on these factors, using the random forest or logistic regression algorithms.(3) results: five key predictive factors in the training set were identified, including the albumin-bilirubin grade, difference average, strength, v5, and v30.After model training, the f1 score, sensitivity, specificity, and accuracy of the final random forest model were 0.857, 100, 93.3, and 94.4% in the test set, respectively.Meanwhile, the logistic regression model yielded an f1 score, sensitivity, specificity, and accuracy of 0.8, 66.7, 100, and 94.4% in the test set, respectively.(4) conclusions: based on clinical, radiomic, and dose-volumetric factors, our models achieved satisfactory performance on the prediction of the occurrence of sbrt-related rild in hcc patients.Before undergoing sbrt, the proposed models may detect patients at high risk of rild, allowing to assist in treatment strategies accordingly.

Journal: Biomedicines (2022)
Publication types: Journal Article
Biofunctionalization of Poly(lactide-co-glycolic acid) Using Potent NorA Efflux Pump Inhibitors Immobilized on Nanometric Alpha-Zirconium Phosphate to Reduce Biofilm Formation.

Polymeric composites, where bioactive species are immobilized on inorganic nanostructured matrix, have received considerable attention as surfaces able to reduce bacterial adherence, colonization, and biofilm formation in implanted medical devices.In this work, potent in-house s.Aureus nor a efflux pump inhibitors (epis), belonging to the 2-phenylquinoline class, were immobilized on nanometric alpha-zirconium phosphate (zr p) taking into advantage of acid-base or intercalation reactions.The zr p/epi were used as filler of poly(lactide-co-glycolic acid) (plga) to obtain film composites with a homogeneous distribution of the zr p/epi fillers.As reference, plga films loaded with zr p intercalated with thioridazine (tz), that is recognized as both a nor a and biofilm inhibitor, and with the antibiotic ciprofloxacin (cpx) were prepared.Composite films were characterized by x-ray diffraction, scanning electron microscopy, and thermogravimetric analysis.The ability of the composite films, containing zr p/epi, to inhibit biofilm formation was tested on staphylococcus aureus atcc 29213 and staphylococcus epidermidis atcc 12228, and it was compared with that of the composite loaded with zr p/tz.Finally, the antibacterial activity of cpx intercalated in zr p was evaluated when used in combination with zr p/epi in the plga films.

Journal: Materials (Basel, Switzerland) (2021)
Publication types: Journal Article
Micro-CT Evaluation of Different Root Canal Irrigation Protocols on the Removal of Accumulated Hard Tissue Debris: A Systematic Review and Meta-Analysis.

Accumulated hard tissue debris (ahtd) is an inevitable by-product during endodontic treatment and is difficult to remove completely using traditional syringe and needle irrigation (sni).Adjunctive irrigation is proposed to assist the clean-up of ahtd.This systematic review and meta-analysis aimed to evaluate the ahtd removal efficacy of different root canal irrigation devices using micro-computed tomography (micro-ct).A literature search was carried out within the main scientific databases until 20 june 2022.All results were screened with detailed eligibility criteria.Eleven studies were included for analysis.Sni, passive ultrasonic irrigation (pui), negative pressure systems, sonically activated irrigation (sai), mechanical-activated system and laser-activated irrigation (lai) were assessed.Pui is superior to sni for debris removal and lai has better ahtd removal performance than pui.The negative pressure system and mechanical-activated system were proved to be less effective.Registration: prospero (crd42021273892).

Journal: Journal of clinical medicine (2022)
Publication types: Journal Article;Review
Transition to Turbulence Downstream of a Stenosis for Whole Blood and a Newtonian Analog Under Steady Flow Conditions.

Blood, a multiphase fluid comprised of plasma, blood cells, and platelets, is known to exhibit a shear-thinning behavior at low shear rates and near-newtonian behavior at higher shear rates.However, less is known about the impact of its multiphase nature on the transition to turbulence.In this study, we experimentally determined the critical reynolds number at which the flow began to transition to turbulence downstream of eccentric stenosis for whole porcine blood and a newtonian blood analog (water-glycerin mixture).Velocity profiles for both fluids were measured under steady-state flow conditions using an ultrasound doppler probe placed 12 diameters downstream of eccentric stenosis.Velocity was recorded at 21 locations along the diameter at 11 different flow rates.Normalized turbulent kinetic energy was used to determine the critical reynolds number for each fluid.Blood rheology was measured before and after each experiment.Tests were conducted on five samples of each fluid inside a temperature-controlled in vitro flow system.The viscosity at a shear rate of 1000 s-1 was used to define the reynolds number for each fluid.The mean critical reynolds numbers for blood and water-glycerin were 470 ± 27.5 and 395 ± 10, respectively, indicating a ∼19% delay in transition to turbulence for whole blood compared to the newtonian fluid.This finding is consistent with a previous report for steady flow in a straight pipe, suggesting some aspect of blood rheology may serve to suppress, or at least delay, the onset of turbulence in vivo.

Journal: Journal of biomechanical engineering (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Drug repurposing for the treatment of COVID-19: Pharmacological aspects and synthetic approaches.

In december 2019, a new variant of sars-co v emerged, the so-called acute severe respiratory syndrome coronavirus 2 (sars-co v-2).This virus causes the new coronavirus disease (covid-19) and has been plaguing the world owing to its unprecedented spread efficiency, which has resulted in a huge death toll.In this sense, the repositioning of approved drugs is the fastest way to an effective response to a pandemic outbreak of this scale.Considering these facts, in this review we provide a comprehensive and critical discussion on the chemical aspects surrounding the drugs currently being studied as candidates for covid-19 therapy.We intend to provide the general chemical community with an overview on the synthetic/biosynthetic pathways related to such molecules, as well as their mechanisms of action against the evaluated viruses and some insights on the pharmacological interactions involved in each case.Overall, the review aims to present the chemical aspects of the main bioactive molecules being considered to be repositioned for effective treatment of covid-19 in all phases, from the mildest to the most severe.

Journal: Bioorganic chemistry (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Analysis of risk factors for early stent thrombosis in the Chinese population: A multicenter restrospective study.

The predictive scoring systems for early stent thrombosis (est) remains blank in china.The study aims to evaluate the risk factors and conduct a prediction model of est in the chinese population.Methods est was defined as thrombosis that occurs within the first 30 days after primary percutaneous coronary intervention (pci).Patients from ten chinese hospitals diagnosed as stent thrombosis (st) from january 2010 to december 2016 were retrospectively included as the study group.A control group (1 case:2 controls) was created by including patients without st, major adverse cardiovascular events, or cerebrovascular events during follow-up.The present study evaluated 426 patients with single-vessel lesions and ultimately included 40 patients with est and 80 control patients, who were included to identify factors that predicted est and to develop a prediction scoring system.The other 171 patients without integrated 1:2 pair were used for external validation.Results est was independently associated with a low hemoglobin concentration (adjusted odds ratio [or] 0.946, 95% confidence interval [95%ci] 0.901-0.993,p=0.026), a high pre-pci synergy between percutaneous coronary intervention with taxus and cardiac surgery (syntax) score (or1.166, 95%ci1.049-1.297,p=0.004), and a dapt (dapt) duration of <30 days (or28.033, 95%ci5.302-272.834,p<0.001).The simple est prediction score provided an area under the curve (auc) of 0.854 (95%ci0.777-0.932,p<0.001) with 70.0% sensitivity and 90.0% specificity, and 0.742 (95%ci0.649-0.835,p<0.001) with 54.5% sensitivity and 81.0% specificity for external validation dataset.Conclusions est may be independently associated with dapt discontinuation within 30 days, a low hemoglobin concentration, and a high syntax score.The scoring system also has a good ability to predict the risk of est and may be useful in the clinical setting.

Journal: World journal of emergency medicine (2021)
Publication types: Journal Article
Pharmacodynamic and immunomodulatory effects of polymyxin B in combination with fosfomycin against KPC-2-producing Klebsiella pneumoniae.

Determining the role of the immune response in preventing antimicrobial resistance and optimising antibiotic regimens against carbapenemase-producing klebsiella pneumoniae is a research gap that exists and needs to be further explored.The objective of this study was to determine the pharmacodynamic and immunomodulatory effects of fosfomycin alone and in combination with polymyxin b against kpc-2-producing k.Pneumoniae clinical isolates.Six k.Pneumoniae isolates were selected (polymyxin b mic, 0.5-64 mg/l; fosfomycin mic, 16-128 mg/l) to evaluate the pharmacodynamics of monotherapy and combination therapies in static time-kill studies.A mechanism-based model was used to characterise the joint activity of polymyxin b and fosfomycin.A549 human airway epithelial cells were infected with four isolates to evaluate the immunomodulatory effects of treatment.Our mechanism-based model indicated greater bacterial killing efficacy of fosfomycin with polymyxin b compared with monotherapy.In combination, polymyxin b was assumed to exert an outer membrane effect that resulted in an increase in the ability of fosfomycin to reach its target site.The mechanism-based model described the data well across all six strains, with r2values ranging from 0.705-0.935.Combination therapy reduced k.Pneumoniae-induced il-6 and il-8 but not tnfα expression.The reduction in cytokine expression was greater with polymyxin b than fosfomycin alone; combination therapy showed significantly greater reduction compared to either monotherapy.Our findings suggest that further research is needed to better understand immune-mediated killing in order to identify a strategy which harnesses the power of the immune response against these hard-to-treat bacteria.

Journal: International journal of antimicrobial agents (2022)
Publication types: Journal Article