syedzayyan/paper_mill_benchmark huggingface dataset:
Effects of Plasma Exchange Combined with Immunoglobulin Therapy on Consciousness, Immune Function, and Prognosis in Patients with Myasthenia Gravis Crisis: A Prospective Randomized Test

Myasthenia gravis (mg) is an acquired autoimmune disease.The main clinical features of mg are skeletal muscle fatigue and pathological fatigue, which worsen at night or after fatigue, such as dyspnea, dysphagia, and systemic weakness.Plasma exchange (pe) is often used in patients with acute exacerbation of mg.Intravenous immunoglobulin (ivig) is a collection of immunoglobulins from thousands of donors.Ivig can replace a variety of immunosuppressants or pe.However, the effect of pe or ivig on patients’ consciousness, immune function, and prognosis is not clear.Objective.A prospective randomized test of the effects of pe combined with immunoglobulin on consciousness, immune function, and prognosis in patients with myasthenia gravis crisis (mgc).Methods.Sixty patients with mgc treated from february 2019 to april 2021 were enrolled in our hospital.The cases who received pe were set as the pe group, and those who received pe combined with immunoglobulin were set as the pe+immunoglobulin group.The efficacy, clinical score, state of consciousness, immune function, acetylcholine receptor antibody (ach r-ab), lymphocyte (lym), albumin (alb) levels, and the incidence of adverse reactions were compared.Results.The improvement rate was 100.005% in the treatment group and 83.33% in the pe group.After treatment, the clinical score of the pe+immunoglobulin group was lower than that of the pe group, and the clinical relative score of the pe+immunoglobulin group was higher than that of the pe group ( p &lt; 0.05 ).The number of conscious people in the pe+immunoglobulin group was more than that in the pe group ( p &lt; 0.05 ).Immunoglobulin a, immunoglobulin m, immunoglobulin g, and immunoglobulin g in the pe+immunoglobulin group were higher than those in the pe group ( p &lt; 0.05 ).The levels of ach r-ab and alb in the pe+immunoglobulin group were higher than those in the pe group, while the level of lym in the pe+immunoglobulin group was lower than that in the pe group.The incidence of skin system, gastrointestinal system, nervous system, and systemic damage in the pe+immunoglobulin group was lower than that in the pe group ( p &lt; 0.05 ).Conclusion.The treatment of mgc with pe combined with immunoglobulin can not only effectively enhance the consciousness and immune function of patients but also effectively promote the prognosis, and the safety of treatment can be guaranteed.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Effects of Peripherally Inserted Central Catheter (PICC) Catheterization Nursing on Bloodstream Infection in Peripheral Central Venous Catheters in Lung Cancer: A Single-Center, Retrospective Study

Peripherally inserted central catheter (picc), as one of the important intravenous routes for the rescue and treatment of critically ill patients, has been widely used in the fluid resuscitation of critically ill patients in intensive care.In particular, picc can be widely used in the treatment of cancer patients.With the wide application of peripheral central venous catheterization, the clinical findings of bloodstream infection complications caused by picc have gradually attracted the attention of doctors and patients.Aims.To investigate the effect of specialized placement and picc placement care on patients with lung cancer who underwent picc puncture.Patients were selected and divided into a comparison group and an observation group of 40 patients each according to the randomized residual grouping method.In the comparison group, routine picc placement and catheter maintenance were performed, while the observation group was provided with specialized placement and picc placement care.The differences in immune and tumor marker levels and nursing compliance between the two groups were observed and compared before and after nursing care.Results.There was no significant difference in the comparison of tumor marker levels between the two groups of patients before care, while the levels of cyfra21-1, ca125, and vgef in the observation group were significantly lower than those in the comparison group after care, and this difference was statistically significant ( p &lt; 0.05 ).There was no statistically significant difference in the comparison of immune levels between the two groups before care ( p &gt; 0.05 ), while the comparison of cd4+, cd3+, and cd4+/cd8+ after care was significantly different and higher in the observation group than in the comparison group, and the comparison was statistically significant ( p &lt; 0.05 ).The compliance rate of 93.8% in the observation group was significantly higher than that of 77.9% in the comparison group, and this difference was statistically significant for comparison ( p &lt; 0.05 ).Conclusion.Picc placement care is more effective in patients with lung cancer and performing picc puncture, significantly improves patients’ immune and tumor marker levels, improves patients’ negative emotions, reduces disease uncertainty, and improves nursing compliance.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Effects of miR-124-3p Silencing on Neuronal Damage in the Hippocampus of Depression Rats by Regulating STAT3 Gene

A large amount of evidence shows that the abnormal expression of mi rna plays an important role in the development of depression.Therefore, we investigated the effect of mi r-124-3p on neuronal damage in the hippocampus of depression rats.Methods.The target genes of mi r-124-3p were predicted by the database; the depression model was prepared by subcutaneous injection of corticosterone (cort), and lv-mi r-124-3p asponge lentiviral suspension was given to determine the weight of rats and open-field test, sugar preference experiment, serum cort, 5-ht, da, and ne were measured, observe and record the behavior of rats, including behavior, diet, and hair.The expression of mi r-124-3p, stat3, bcl-2, and bax in rat hippocampus was measured.The rat hippocampal neuron cells were extracted and transfected with mi r-124-3p inhibitor; the cells were cultured with cort, and the cell survival rate was evaluated by mtt experiment, and the expressions of mi r-124-3p, stat3, bcl-2, and bax in the cells were detected.Luciferase reporter gene verifies the targeted regulation of mi r-124-3p on stat3.Results.Compared with depression rats, silencing mi r-124-3p increased the weight of the rats, increased the number of open-field activities, and significantly improved the general state and pathological state of the rats.The sugar water preference rate was significantly increased, the cort content in the serum of rats decreased significantly, and the levels of 5-ht, da, and ne increased significantly.After the treatment of silencing mi r-124-3p, the expression level of mi r-124-3p was decreased, while the stat3 m rna and protein expression levels were increased.And the protein and m rna expression levels of bcl-2 were increased, and the bax protein and m rna expression were decreased.Cell experiments verified that silencing mi r-124-3p increased cell survival, the expression level of mi r-124-3p decreased remarkably, while the expression levels of stat3 m rna and protein increased significantly.Silencing mi r-124-3p reversed the effects of cort treatment on mi r-124-3p and stat3 in neuronal cells.The luciferase reporter gene experiment confirmed that mi r-124-3p targets and regulates stat3 expression.Conclusion.Silencing mi r-124-3p may protect hippocampal neurons from damage in depression rats by upregulating stat3 gene.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Effects of Metoprolol Succinate Combined with Entresto on Cardiac Function Indexes and Coagulation Function in Patients with Congestive Heart Failure

To investigate the effects of metoprolol succinate combined with entresto (sacubitril valsartan sodium tablets) on cardiac function and coagulation function in patients with congestive heart failure (chf).Methods.About 120 patients with chf treated from april 2018 to april 2021 were enrolled in our hospital.The patients were arbitrarily assigned into control group and study group.The control group was cured with metoprolol succinate sustained-release tablets, and the study group was cured with metoprolol succinate sustained-release tablets combined with entresto.The curative effect, cardiac function, vascular endothelial function, oxidative stress, and coagulation function were compared.Results.First of all, we compared the general data, and there exhibited no difference in age, sex, course of disease, hypertension, coronary heart disease, diabetes, atrial fibrillation, and other general data ( p &gt; 0.05 ).Second, we compared the clinical efficacy.The effective rate of the study group (98.33%) was higher (90.00%) ( p &lt; 0.05 ).There exhibited no significant difference in cardiac function indexes before treatment, but after treatment, lvef increased, lvesd and lvedd decreased, lvesd and lvedd in the study group were lower, and lvef in the study group was higher ( p &lt; 0.05 ).Before treatment, there exhibited no significant difference in vascular endothelial function.However, the levels of cgrp and et increased and the level of no decreased, and the level of no in the study group was lower, while the levels of cgrp and et in the study group were higher after treatment ( p &lt; 0.05 ).There exhibited no significant difference in oxidative stress indexes before treatment, however, the levels of gsh-px and sod increased and the levels of mda decreased after treatment, while the level of mda in the study group was lower, while the levels of gsh-px and sod in the study group were higher ( p &lt; 0.05 ).Finally, we compared the indexes of blood coagulation function.There exhibited no significant difference before treatment, but after treatment, the levels of aptt, pt, and fib decreased, and the levels of aptt, pt, and fib in the study group were lower ( p &lt; 0.05 ).Conclusion.Clinical practice demonstrated that lvesd and lvedd decreased and lvef increased after treatment with entresto combined with metoprolol in chf patients, which can effectively facilitate cardiac function and vascular endothelial function, reduce oxidative stress reaction, and improve blood coagulation indexes, suggesting that entresto combined with metoprolol can improve ventricular remodeling with good safety.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Effects of Laparoscopic Hyperthermic Perfusion Therapy Combined with Adjuvant Treatment of Compound Yew Capsule on Ovarian Blood Flow Parameters and Immune Function in Patients with Ovarian Cancer

To determine the effects of laparoscopic hyperthermic perfusion therapy combined with adjuvant compound yew capsules on ovarian blood flow parameters and immune function in patients with ovarian cancer (oc).Methods.A total of 90 oc patients enrolled in our hospital between january 2019 and january 2020 were randomly distributed into the control (con group) and experimental group (exp group) based on the sealed envelope method.The con group was administered laparoscopic hyperthermic perfusion therapy.On this basis, the exp group was subjected to compound yew capsules; the ovarian blood flow parameters and immune function indexes were compared between the two groups.Results.The exp group was reported to perform better than the con group regarding ovarian blood flow parameters and immune indexes after treatment ( p &lt; 0.001 ).Conclusion.Laparoscopic hyperthermic perfusion therapy combined with adjuvant compound yew capsules for patients with oc can substantially improve the clinical indexes and immune function.Furthermore, research and adequate promotion are needed to elicit the evidence beyond preclinical studies to understand the intricacies of its implementation.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Effects of Hypoxia-Inducible Factor 1 (HIF-1) Signaling Pathway on Acute Ischemic Stroke

Epidemiological surveys show that a large number of cerebrovascular diseases occur in china every year, and among these cerebrovascular diseases, ischemic diseases are predominant.Ischemia leads to irreversible degenerative necrosis of a large number of brain neurons and severe neurological deficits.Aims.This study is aimed at exploring the mechanism of the major regulatory effect of hypoxia-inducible factor 1 (hif-1) pathway on proangiogenesis and providing new ideas for the treatment of ischemic stroke.Materials and methods.The rats were randomly divided into normal and ischemic control groups, and the ischemic control group was subjected to the middle cerebral artery occlusion (mcao) cerebral ischemia model by the wire embolization method, and the rats were executed in batches at 6 h, 1 d, and 3 d after ischemia-reperfusion, and the brain tissue specimens were taken for examination to investigate the effect of hypoxia-inducible factor 1 (hif-l) signaling pathway on acute ischemic stroke.Results.At 3 d, the number of vegfr2 positive cells increased significantly, and there was a significant difference compared with the control group ( p &lt; 0.05 ).At 3 d, the number of hif-1α-positive cells increased significantly, and there was a significant difference compared with the control group ( p &lt; 0.05 ).The number of hes1+factor viii positive cells in the ischemic cortex increased significantly on the 1st and 3rd day, and there was a significant difference compared with the control group ( p &lt; 0.05 ).The expression of hes1 protein was significantly lower than the normal level after 6 h of ischemia, and the protein expression was significantly increased at 1 d and 3 d after ischemia ( p &lt; 0.05 ).Conclusion.By detecting the expression changes of hesl+factor vii in the ischemic area, the results show that ischemia and hypoxia activate the hif-1, making the hif-l the main regulatory pathway in the process of angiogenesis after ischemia.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Effects of CDT on Hemodynamics and Quality of Life in a Subgroup of Patients with Lower Limb Deep Vein Thrombosis Carel: A Case-Control Study

To explore the effects of combined catheter-directed thrombolysis (cdt) on hemodynamics and quality of life in a subgroup of patients with lower limb deep vein thrombosis carel by using a case-control study.Methods.Eighty-four patients with deep venous thrombosis (dvt: acute dvt and chronic dvt) of lower extremities treated in our hospital from april 2017 to june 2021 were randomly assigned into the control group ( n = 42 ) and the research group ( n = 42 ).The control group only received routine nursing combined with cdt; the research group was treated with cluster nursing l combined with cdt.The clinical efficacy, the difference in limb circumference, hemorheology, hemodynamics, coagulation index and life quality before and after treatment, and the nursing satisfaction scores were calculated.The effects of cluster nursing l combined with cdt on hemodynamics and life quality in patients with dvt of lower extremities were analyzed.Results.The clinical curative effect of the research group was better than that of the control group ( p &lt; 0.05 ).After intervention, the difference in the thigh and leg perimeter in the research group was reduced, and the difference in the thigh and leg perimeter in the research group was significantly lower than that in the control group ( p &lt; 0.05 ).After intervention, the whole blood low shear viscosity, plasma viscosity, platelet aggregation rate, and fibrinogen in the research group were lower than those in the control group ( p &lt; 0.05 ).After intervention, segmental venous volume (svc), maximum venous blood flow (mvo), and svc/mvo in the research group were significantly higher than those before intervention, vrt was significantly prolonged, and mvo and venous pressure recovery time (vrt) were significantly higher than those in the control group.After intervention, d-dimer and fibrinogen decreased, prothrombin time and activated partial thromboplastin time increased in the research group, and the improvement of blood coagulation index in the research group was significantly better than that in the control group ( p &lt; 0.05 ).After intervention, the scores of quality of life in the research group decreased, and the scores of physiological function, psychological function, social function, and health self-cognition in the research group were lower than those in the control group ( p &lt; 0.05 ).The satisfaction of patients in the research group was significantly higher than that in the control group ( p &lt; 0.05 ).Conclusion.The application of cluster nursing l combined with cdt can effectively prevent lower limb venous thrombosis after operation and can enhance patients’ hemorheology, hemodynamics, and blood coagulation function and significantly promote their life quality, nursing satisfaction is high, and it is worth popularizing and applying in clinic.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Effects of Apatinib Mesylate Monotherapy on the Incidence of Adverse Reactions and Immune Function in Patients with Breast Cancer after Radical Mastectomy

To assess the effects of monotherapy with apatinib mesylate on the incidence of adverse events and immune function in breast cancer patients after a radical mastectomy.Methods.Between december 2018 and august 2020, 90 patients with breast cancer scheduled for a radical mastectomy in people’s liberation army navy 971 hospital were randomly recruited and assigned at a ratio of 1 : 1 to receive either conventional treatment (conventional group) or apatinib mesylate after radical mastectomy (study group).The primary endpoint was disease control rate (dcr), and the secondary endpoints were adverse events and the immune function of the patients.Results.Monotherapy with apatinib mesylate was associated with a higher dcr (86.67%) versus conventional postoperative treatment (42.23%).All patients in the study group had documented adverse events, including 2 (4.45%) cases of headache, 3 (6.67%) cases of dizziness, 9 (20.00%) cases of hypertension, 6 (13.34%) cases of hand-foot syndrome, 3 (6.67%) cases of thrombocytopenia, 1 (2.23%) case of tinnitus, 7 (15.56%) cases of fatigue, 2 (4.45%) cases of anemia, 2 (4.45%) cases of oral pain, and 10 (22.23%) cases of leukopenia.There were 23 cases of intermittent discontinuation due to adverse events during treatment, 15 cases of dose reduction, and 3 cases of discontinuation due to adverse events.The difference in preoperative and postoperative t-cell subsets and natural killer (nk) cells between the two groups did not come up to the statistical standard ( p &gt; 0.05 ).Monotherapy with apatinib mesylate resulted in significantly lower levels of cd4+, cd4+/cd8+, and nk cells and higher cd8+ levels versus conventional treatment at 1 week and 4 weeks postoperatively ( p &lt; 0.05 ).Conclusion.Apatinib mesylate monotherapy after radical mastectomy yields a high dcr, a lower incidence of adverse events, and improved immune recovery.Clinical trials are, however, required prior to clinical promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Effects and Safety of Sacubitril/Valsartan for Patients with Myocardial Infarction: A Systematic Review and Meta-Analysis

Patients who develop heart failure (hf) after an acute myocardial infarction (ami) are at higher risk of adverse fatal and nonfatal outcomes.Studies have shown sacubitril/valsartan can further reduce the risk of cardiovascular death or hospitalization for heart failure by 20% compared with enalapril.At the same time, its tolerance and safety are better.However, the current evidence regarding the efficacy of sacubitril/valsartan in patients with heart failure after acute myocardial infarction is controversial.To assess the effect of sacubitril/valsartan on heart failure after acute myocardial infarction, we conducted a systematic review of the literature and a meta-analysis of existing randomized clinical trials.Meta-analysis of randomized controlled trails is used where data are collected from pub med, the cochrane library, embase, and web of science.Data about sacubitril/valsartan were available from 5 studies.Forest plots showed that the sacubitril/valsartan group had a 299% higher value of sacubitril/valsartan to the control group (md = 2.99%, 95% ci: 2.01, 3.96, i2 = 78%, p &lt; 0.00001 , figure 2), and the difference was statistically significant.Forest plots showed that the sacubitril/valsartan group had a 531% lower value of lvef to the control group (md = −5.31%, 95% ci: −7.36, −3.26, i2 = 91%, p &lt; 0.00001 , figure 2), and the difference was statistically significant.Forest plots showed that the sacubitril/valsartan group had a 133% lower value of nt-pro bnp to the control group (md = −1.33%, 95% ci: −1.54, −1.12, i2 = 96%, p &lt; 0.00001 , figure 3).Forest plots showed that the sacubitril/valsartan group had a 49% lower risk of heart failure to the control group (md = 0.49, 95% ci: 0.27, 0.89, i2 = 0%, p = 0.02 , figure 3).The patients in experimental showed an obviously lower or of mace (or = 0.47, 95% ci: 0.27, 0.82, p = 0.007 , figure 3).The data were statistically significant.We have observed that for patients with heart failure after acute myocardial infarction, early administration of sacubitril/valsartan can significantly reduce the incidence of heart rate, left ventricular ejection fraction, nt-pro bnp, and mace.Our meta-analysis suggests that taking sacubitril/valsartan is relatively safe and effective, especially if started early after acute myocardial infarction.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Meta-Analysis;
Effectiveness of Super-selective Embolization for Parasagittal Meningiomas and Its Effect on the Level of Inflammatory Factors

To evaluate the effectiveness of super-selective embolization for parasagittal meningiomas and its effect on the level of inflammatory factors.Methods.A total of 48 patients with parasagittal meningiomas diagnosed and treated in our hospital from september 2018 to march 2020 were randomly included and assigned to receive meningioma resection (control group) or meningioma resection plus super-selective embolization (study group), with 24 patients in each group.Outcome measures included clinical indices, tumor resection outcome, inflammatory factor levels, and follow-up results.Results.Patients in the study group had shorter operative time and less intraoperative bleeding volume than those in the control group ( p &lt; 0.05 ).The study group had more patients with simpson i resection (87.50%) than the control group (62.50%) ( p &lt; 0.05 ).There was no statistically significant difference in the levels of inflammatory factors between the two groups of patients before treatment ( p &gt; 0.05 ).After treatment, the levels of interleukin (il)-6, tumor necrosis factor (tnf)-α, and hypersensitive c-reactive protein (hs-crp) in patients in the study group were significantly lower than those of the control group.The results of the three-month follow-up showed that one patient in the study group was reoperated for tumor recurrence and there was no death record, while three patients in the control group were reoperated for tumor recurrence and one patient died.The difference in the recurrence and mortality between the two groups did not come up to the statistical standard ( p &gt; 0.05 ).Conclusion.Super-selective embolization for parasagittal meningiomas contributes to reducing intraoperative bleeding, effectively improving tumor resection and surgical safety, and lowering inflammatory factor levels.Further trials are, however, required before clinical promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;