syedzayyan/paper_mill_benchmark huggingface dataset:
Development and validation of a nomogram for predicting significant coronary artery stenosis in suspected non-ST-segment elevation acute coronary artery syndrome with low-to-intermediate risk stratification.

Patients with non-st-segment coronary artery syndrome (nste-acs) have significant heterogeneity in their coronary arteries.A better assessment of significant coronary artery stenosis (scas) in low-to-intermediate risk nste-acs patients would help identify who might benefit from invasive coronary angiography (ica).Our study aimed to develop a multivariable-based model for pretesting scas in suspected nste-acs with low-to-intermediate risk.Methods this prediction nomogram was constructed retrospectively in 469 suspected nste-acs patients with low-to-intermediate risk.Patients were divided into a development group (n= 331, patients admitted to hospital before 1 may 2021) and a temporal validation group (n= 138, patients admitted to hospital since 1 may 2021).The outcome was existing scas, including left main artery stenosis ≥50% or any subepicardial coronary artery stenosis ≥70%, all confirmed by invasive coronary angiography.Pretest predictors were selected using least absolute shrinkage and selection operator (lasso) and stepwise logistic regression.Results derivation analyses from the development group (n= 331, admitted before 1 may 2021) generated the 7 strongest predictors out of 25 candidate variables comprising smoker, diabetes, heart rate, cardiac troponin t, n-terminal pro-b-type natriuretic peptide, high-density lipoprotein cholesterol, and left atrial diameter.This nomogram model showed excellent discrimination ability with an area under the receiver operating characteristic curve (auc) of 0.83 in the development set and 0.79 in the validation dataset.Good calibration was generally displayed, although it slightly overestimated patients' scas risk in the validation group.Decision curve analysis demonstrated the clinical benefit of this model, indicating its value in clinical practice.Furthermore, an optimal cut-off of prediction probability was assigned as 0.61 according to the youden index.Conclusion a prediction nomogram consisting of seven readily available clinical parameters was established to pretest the probability of scas in suspected nste-acs patients with low-to-intermediate risk, which may serve as a cost-effective risk stratification tool and thus assist in initial decision making.

Journal: Frontiers in cardiovascular medicine (2022)
Publication types: Journal Article
A fresh look at coronary microembolization.

Mechanical stress from haemodynamic perturbations or interventional manipulation of epicardial coronary atherosclerotic plaques with inflammatory destabilization can release particulate debris, thrombotic material and soluble substances into the coronary circulation.The physical material obstructs the coronary microcirculation, whereas the soluble substances induce endothelial dysfunction and facilitate vasoconstriction.Coronary microvascular obstruction and dysfunction result in patchy microinfarcts accompanied by an inflammatory reaction, both of which contribute to progressive myocardial contractile dysfunction.In clinical studies, the benefit of protection devices to retrieve atherothrombotic debris during percutaneous coronary interventions has been modest, and the treatment of microembolization has mostly relied on antiplatelet and vasodilator agents.The past 25 years have witnessed a relative proportional increase in non-st-segment elevation myocardial infarction in the presentation of acute coronary syndromes.An associated increase in the incidence of plaque erosion rather than rupture has also been recognized as a key mechanism in the past decade.We propose that coronary microembolization is a decisive link between plaque erosion at the culprit lesion and the manifestation of non-st-segment elevation myocardial infarction.In this review, we characterize the features and mechanisms of coronary microembolization and discuss the clinical trials of drugs and devices for prevention and treatment.

Journal: Nature reviews. Cardiology (2022)
Publication types: Journal Article;Review
Emotional voices modulate perception and predictions about an upcoming face.

When we hear an emotional voice, does this alter how the brain perceives and evaluates a subsequent face?Here, we tested this question by comparing event-related potentials evoked by angry, sad, and happy faces following vocal expressions which varied in form (speech-embedded emotions, non-linguistic vocalizations) and emotional relationship (congruent, incongruent).Participants judged whether face targets were true exemplars of emotion (facial affect decision).Prototypicality decisions were more accurate and faster for congruent vs.Incongruent faces and for targets that displayed happiness.Principal component analysis identified vocal context effects on faces in three distinct temporal factors: a posterior p200 (150-250 ms), associated with evaluating face typicality; a slow frontal negativity (200-750 ms) evoked by angry faces, reflecting enhanced attention to threatening targets; and the late positive potential (lpp, 450-1000 ms), reflecting sustained contextual evaluation of intrinsic face meaning (with independent lpp responses in posterior and prefrontal cortex).Incongruent faces and faces primed by speech (compared to vocalizations) tended to increase demands on face perception at stages of structure-building (p200) and meaning integration (posterior lpp).The frontal lpp spatially overlapped with the earlier frontal negativity response; these components were functionally linked to expectancy-based processes directed towards the incoming face, governed by the form of a preceding vocal expression (especially for anger).Our results showcase differences in how vocalizations and speech-embedded emotion expressions modulate cortical operations for predicting (prefrontal) versus integrating (posterior) face meaning in light of contextual details.

Journal: Cortex; a journal devoted to the study of the nervous system and behavior (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Efficacy and safety of percutaneous renal biopsy performed using 18G needle versus 16G needle: a single-center retrospective study.

At present, both 16g and 18g needles are used for percutaneous renal biopsy in china.This study aimed to compare the efficacy and safety of biopsy performed with the 18g needle vs.The 16g needle.Methods the data of patients who underwent percutaneous renal biopsy at our hospital between january 2015 and december 2019 were retrospectively analyzed.The number of glomeruli obtained by puncture and postoperative complications were compared between patients undergoing biopsy with the 16g and 18g needles.Continuous variables were compared by the t test or the mann-whitney u test, and categorical variables by the chi-square test.Correlation analysis was used to examine the relationship of different variables with hematoma size.Results of the total 3138 kidney biopsies, 2526 were performed with the18g needle and 612 with the 16g needle.The number of glomeruli obtained was not significantly different between the two groups (p = 0.078).Large hematomas were significantly more common the 16g group than in the 18g group (9.31% vs.5.98%, p = 0.003).Arteriovenous fistula was also more common in the 16g group (1.14% vs.0.23%, p = 0.005).Other complications were rare, with similar incidence in the two groups.Conclusion the 18g needle is as effective as the 16g needle for percutaneous renal biopsy.The risk of large hematoma and arteriovenous fistula appear to be lower with the 18g needle.

Journal: International urology and nephrology (2022)
Publication types: Journal Article
Clostridial panophthalmitis - An unusual case of localised malignant oedema in Merino lambs associated with Clostridium chauvoei.

The authors report an unusual case of clostridium chauvoei causing severe panophthalmitis in merino lambs.More than half of the lambs affected survived, which is unusual for clostridial disease; however, there have been reports in humans that the mortality risk for ocular gas gangrene is lower than when other body parts are affected.A combination of factors in this case included environmental contamination (specific to a particular paddock), genetics predisposing to entropion (lambs born of maiden 2-year-old ewes with some inbreeding), the practice of manually everting eyelids for the entropion and vaccination strategies.C.Chauvoei was cultured in pure growth from the eye of a lamb affected by severe panophthalmitis.Histopathology was consistent with severe acute infection, and microscopic sections showed gram-positive organisms associated with the inflammatory response in the eye.In the acutely affected animal examined there were no signs that the lesions were long-standing.Animals that recovered had one or both eyes destroyed.This report describes that malignant oedema in sheep due to c.Chauvoei can manifest as acute and severe panophthalmitis.The case fatality rate of lambs with panophthalmitis was less than 50%, lower than normally occurs for clostridial diseases.Clostridial vaccination of the ewes may have provided a low level of protection in reducing the case fatality rate in the affected lambs as well localisation of the infection from the blood-ocular barrier.

Journal: Australian veterinary journal (2022)
Publication types: Case Reports;Journal Article
Preoperative Dexamethasone for Airway-Related "Calibration Tube" Complications After Sleeve Gastrectomy: a Randomised Clinical Trial.

Bariatric surgeries utilise bougie device to guide stomach resection.The device implementation is associated with many underreported complications.This study aims to compare nebulised vs.Intravenous preoperative dexamethasone in mitigating airway-related bougie complications after sleeve gastrectomy.Methodology this is a prospective double-blinded interventional study conducted by a tertiary hospital.The study involved 105 patients allocated to 3 groups: group (i) received 8 mg dexamethasone intravenously (iv) preoperatively, group (n) received 8 mg dexamethasone from a nebulizer mask preoperatively, and group (s) received nebulised normal saline.Outcomes evaluated were postoperative sore throat, odynophagia, change of voice, and nausea and vomiting.Results nebulized dexamethasone was found to be significantly superior to iv dexamethasone in terms of postoperative sore throat at zero-hour (p = 0.001) and 1-h intervals (p = 0.011).No significant difference was found at 6- and 24-h intervals.For odynophagia, post hoc analysis showed there was no significant difference between (i), (n), and (s) groups.Incidence of change of voice was significantly lower in (n) and (i) groups compared to (s) group, with p values of 0.0067 and 0.00014, respectively.The incidence of post-operative sore-throat (ponv) in (i) group was significantly lower than incidences in (s) group (p = 0.00002) and (n) group (p = 0.0004).Conclusion preoperative nebulized and iv dexamethasone are effective strategies in mitigating complications related to mechanical effects of bougie insertion.Iv dexamethasone was as effective as nebulized dexamethasone in terms of late postoperative sore throat, and was superior in postoperative nausea and vomiting.

Journal: Obesity surgery (2021)
Publication types: Journal Article;Randomized Controlled Trial
The impact of symmetry design of intangible cultural heritage souvenir on tourists' aesthetic pleasure.

Souvenirs play an important role in tourism development.They act not only as mementos, enabling tourists to relive and retain the memory of a particular journey, but also as main income sources for tourism destinations and stakeholders.Many intangible cultural heritages (ich) have been developed into souvenirs, especially products made by traditional craftsmanship.Ich souvenirs facilitate cultural value that is understandable to tourists, who appreciate the design of the ich souvenirs and their contributions to a pleasure and memorable journey.Based on the theory of beauty and the preference-for-prototypes theory, this study explored how symmetry design of ich souvenirs influences tourist's aesthetic pleasure.As ich souvenirs development is a commercialization process, and over-commodification would lead to cultures being lost and tourists' disappointment, the authenticity concept is applied in order to address over-commodification.Thus, this study analyzed the moderating role of tourists' authenticity perception of ich souvenirs.Two lab-based between-subjects design experiments were employed to test the proposed hypotheses.Data analysis entailed multiple regression analysis, one-way anova, and two-way anova.The findings showed that symmetry of ich souvenir design had a positive impact on tourists' aesthetic pleasure.Under the symmetric-design condition, tourists' typicality perception of ich souvenirs positively mediated the main relationship, while under the asymmetric-design condition, tourists' novelty perception had a negative mediating effect.The moderated mediation effects were in accord with hypotheses to some extent; at a relatively high level of authenticity perception (above mean value), the indirect effect of symmetry on aesthetic pleasureviatypicality perception increased as authenticity perception rose; at a relatively low level of authenticity perception (under mean value), the indirect effect of symmetry on aesthetic pleasurevianovelty perception declined as authenticity perception rose.This study identified critical factors influencing tourists' aesthetic pleasure with ich souvenirs, and it revealed the internal influencing mechanisms and moderating effects under different design conditions.These findings give some insights to ich practitioners for using souvenir design to improve tourists' aesthetic pleasure.

Journal: Frontiers in psychology (2022)
Publication types: Journal Article
Transdermal Measurement of Glomerular Filtration Rate in Mechanically Ventilated Piglets.

Transdermal measurement of glomerular filtration rate (gfr) has been used to evaluate kidney function in conscious animals.This technique is well established in rodents to study acute kidney injury and chronic kidney disease.However, gfr measurement using the transdermal system has not been validated in pigs, a species with a similar renal system to humans.Hence, we investigated the effect of sepsis on transdermal gfr in anesthetized and mechanically ventilated neonatal pigs.Polymicrobial sepsis was induced by cecal ligation and puncture (clp).The transdermal gfr measurement system consisting of a miniaturized fluorescence sensor was attached to the pig's shaved skin to determine the clearance of fluorescein-isothiocyanate (fitc) conjugated sinistrin, an intravenously injected gfr tracer.Our results show that at 12 h post-clp, serum creatinine increased with a decrease in gfr.This study demonstrates, for the first time, the utility of the transdermal gfr approach in determining renal function in mechanically ventilated, neonatal pigs.

Journal: Journal of visualized experiments : JoVE (2022)
Publication types: Journal Article;Video-Audio Media;Research Support, N.I.H., Extramural
Impacted intraarticular fragments of distal radius fractures: A radiographic characterization and analysis of reliability and diagnostic accuracy.

Reduction using ligamentotaxis may not be effective enough to treat impacted intraarticular fragments of distal radius fractures.Articular incongruence resulting from the loss of reduction is a risk factor for postoperative osteoarthritis and worse clinical outcome.This study aimed to analyze the radiographic characterization of the impacted intraarticular fragments of distal radius fractures using two/three-dimensional computed tomography (ct).Further, we assessed the reliability and diagnostic accuracy in detecting the fragments using plain radiographs.Methods we analyzed 167 three-dimensional ct images of the intraarticular distal radius fractures and selected 12 fractures with impacted intraarticular fragments.We recorded the location, size, and displacement of the fragment using ct images.In addition, six examiners evaluated 25 fractures including those 12 fractures having the fragments using plain radiographs for detecting the fragments and their displacements.Further, we evaluated the reliability and diagnostic accuracy of the plain radiographs in the detection of the fragment.Results fifteen impacted intraarticular fragments were found in 12 wrists.The displacement of the scaphoid facet fragment was significantly larger than that of the lunate facet fragment in ct measurement (7.0 mm and 3.6 mm).Inter and intraobserver reliability of the diagnosis for the fragment in plain radiographs were poor and fair (κ: 0.14 and κ:0.27).Diagnostic accuracy in detecting the fragment in plain radiographs generated mean sensitivity: 0.4, mean specificity: 0.73, and mean accuracy: 0.58.The mean sensitivity in detecting a lunate facet fragment was lower than that of a scaphoid facet fragment in plain radiographs (0.24 and 0.44).Conclusion impacted intraarticular fragments were found in 7% of intraarticular distal radius fractures.We observed low reliability and sensitivity in detecting the fragment using plain radiographs.Preoperative recognition of the fragments using plain radiograph were difficult, even though the magnitude of step-off of the scaphoid facet fragment was large.

Journal: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association (2022)
Publication types: Journal Article
Complications of Scheker semiconstrained distal radioulnar joint arthroplasty in a low-volume unit.

Semiconstrained arthroplasty of the distal radioulnar joint (druj) (scheker prosthesis, aptis medical, glenview, ky, usa) is a treatment option in case of irreparable destruction of the druj.In our unit, a scheker endoprosthesis was implanted in 5 wrists in 4 patients.3/5 wrists (60%) in 3/4 patients (75%) underwent revision surgery.Reasons for revision surgery were implant loosening, periprosthetic fracture of the radius and suspicion of periprosthetic infection.Asymptomatic loosening of the screw of the radial head cover was detected in one wrist.Scheker arthroplasty is technically demanding.The prosthesis is prone to failure over the long term.Before implantation, all patients should be informed of the high risk of revision surgery.

Journal: Hand surgery & rehabilitation (2022)
Publication types: Journal Article
Efficient synthesis 1,4-cyclohexanedicarboxaldehyde by an engineered alcohol oxidase.

In this study, we selected and engineered a flavin adenine dinucleotide (fad)-dependent alcohol oxidase (aox) to produce 1,4-cyclohexanedicarboxaldehyde (chda), an initial raw material for spiral compounds, from 1,4-cyclohexanedimethanol (chdm).First, the structure of alcohol oxidase from arthrobacter cholorphenolicus (ac co) was analyzed, and the mechanism of ac co-catalyzed primary alcohol oxidation was elucidated, demonstrating that the energy barrier of the hydride (h-) transfer (13.4 kcal·mol-1and 20.4 kcal·mol-1) decreases the catalytic efficiency of the primary alcohol oxidation reaction.Therefore, we designed a protein engineering strategy to adjust the catalytically active conformation to shorten the distance of hydride (h-) transfer and further decreased the core energy barrier.Following this strategy, variant w4 (s101a/h351v/n378s/q329n) was obtained with 112.5-fold increased catalytic efficiency to produce chda compared to that of the wild-type strain.The 3 l scale preparation of chda reached a titer up to 29.6 g·l-1with a 42.2% yield by an escherichia coli whole-cell catalyst, which demonstrates the potential of this system for industrial application.

Journal: Bioresources and bioprocessing (2022)
Publication types: Journal Article
Bibliometric indicators to evaluate scientific activity.

Bibliometric indicators have been devised to quantify scientific production and to try to evaluate its impact in the community.In general, bibliometric indicators can be classified according to whether the unit of analysis is the author (individual or group) or journal.The most widely used indicators for authors are those that measure an individual author's production, such as the crown index or the h-index and its derivatives (e-index, h5-index, and the absolute or ab-index, among others).The bibliometric indicators devised to try to evaluate journal quality are associated with journal citation reports (e.g., impact factor, field-weighted citation impact, eigenfactor, and article influence) or with scopus (scimago journal rank (sjr), source normalized impact per paper (snip), and cite score).This article describes the main bibliometric indicators, explains how they are calculated, and discusses their advantages and limitations.

Journal: Radiologia (2021)
Publication types: Journal Article
Nebulized dexmedetomidine improves pulmonary shunt and lung mechanics during one-lung ventilation: a randomized clinical controlled trial.

Dexmedetomidine (dex), a selective a2-adrenergic receptor agonist, has been previously reported to attenuate intrapulmonary shunt during one-lung ventilation (olv) and to alleviate bronchoconstriction.However, the therapeutic effects of nebulized dex on pulmonary shunt and lung mechanics during olv have not been evaluated.Here we determine whether nebulized dexmedetomidine improved pulmonary shunt and lung mechanics in patients undergoing elective thoracic surgery in a prospective randomized controlled clinical trial.Methods one hundred and twenty-eight patients undergoing elective thoracoscopic surgery were included in this study and randomly divided into four groups: 0.9% saline (placebo group), 0.5 μg/kg (dex0.5group), 1 μg/kg (dex1group) and 2 μg/kg (dex2group) dexmedetomidine.After bronchial intubation, patients received different nebulized doses of dexmedetomidine (0.5 μg/kg, 1 μg/kg and 2 μg/kg) or 0.9% saline placebo during two-lung ventilation(tlv).Olv was initiated 15 min after bronchial intubation.Anesthesia was maintained with intravenous infusion of cisatracurium and propofol.Bispectral index values were maintained within 40-50 by adjusting the infusion of propofol in all groups.Arterial blood gas samples and central venous blood gas samples were taken as follows: 15 min after bronchial intubation during two-lung ventilation (tlv15), after 30 and 60 min of olv (olv30and olv60, respectively) and 15 min after reinstitution of tlv (re tlv).Dynamic compliance was also calculated at tlv15, olv30, olv60and re tlv.Results dex decreased the requirement of propofol in a dose-dependent manner(p= 0.000).Heart rate (hr) and mean arterial pressure (map) displayed no significant difference among groups (p= 0.397 and 0.863).Compared with the placebo group, dex administered between 0.5 and 2 μg/kg increased partial pressure of oxygen (pa o2) significantly at olv30and olv60(p= 0.000); however, dex administered between 1 and 2 μg/kg decreased pulmonary shunt fraction (qs/qt) at olv30and olv60(p= 0.000).Compared with the placebo group, there were significant increases with dynamic compliance (cdyn) after olv in dex0.5, dex1and dex2group(p= 0.000).conclusions.nebulized dexmedetomidine improved oxygenation not only by decreasing pulmonary shunt but also by improving lung compliance during olv, which may be effective in managing olv.

Journal: PeerJ (2020)
Publication types: Journal Article
Advances in Pain Medicine: a Review of New Technologies.

Of review this narrative review highlights the interventional musculoskeletal techniques that have evolved in recent years.Recent findings the recent progress in pain medicine technologies presented here represents the ideal treatment of the pain patient which is to provide personalized care.Advances in pain physiology research and pain management technologies support each other concurrently.As new technologies give rise to new perspectives and understanding of pain, new research inspires the development of new technologies.

Journal: Current pain and headache reports (2022)
Publication types: Journal Article;Review