syedzayyan/paper_mill_benchmark huggingface dataset:
Near-infrared (NIR) disrelation mapping analysis for poly(lactic) acid nanocomposite.

Near infrared (nir) imaging data of poly(lactic) acid (pla) nanocomposite were analysed by disrelation mapping to prove the possible interaction between pla matrix and montmorillonite-based nanoclay.The basic concept of disrelation mapping can be viewed as a spatial filter based on two-dimensional (2d) correlation function to elucidate specific areas where disrelated variation between intensities occurs.Correlation intensity develops on disrelation map only if spectral intensities at v1and v2within the local spatial area vary in a dissimilar manner.This feature is especially suitable for identifying the area where interaction between components occurs, which is not fully detected by the conventional visualizations based on a single wavenumber.Disrelation maps constructed with nir bands arising from the crystalline and amorphous components of the pla.The pattern appearing on the disrelation map indicated different distributions of the crystalline and amorphous components of the nanocomposite sample.In addition, the development of disrelation intensity becomes acute especially at the area adjacent to the clay, revealing that the clay essentially works as nucleating agent to cause the additional development of crystalline structure of pla by lowering the surface energy barrier.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2017)
Publication types: Journal Article
Pauses in atrial rhythm in a patient with limb-girdle muscular dystrophy: A case report.

A 58-year-old woman with a history of multi-origin atrial tachycardia and limb-girdle muscular dystrophy was treated for presyncope caused by pauses in atrial rhythm.A dual-chamber pacemaker was implanted.The low-voltage area extended broadly, but 10-v pacing could not capture the large right atrium, including the right atrial appendage, except the coronary sinus ostium.The atrial lead was screwed in using a steerable stylet.A ventricular lead was placed in the right ventricular apex.Atrial pacing at the coronary sinus was required to treat the pauses in the atrial rhythm.

Journal: Journal of electrocardiology (2020)
Publication types: Case Reports;Journal Article
Influence of microbiological culture results on antibiotic choices for veterans with hospital-acquired pneumonia and ventilator-associated pneumonia.

We examined the impact of microbiological results from respiratory samples on choice of antibiotic therapy in patients treated for hospital-acquired pneumonia (hap) or ventilator-associated pneumonia (vap).Design four-year retrospective study.Setting veterans' health administration (vha).Patients vha patients hospitalized with hap or vap and with respiratory cultures between october 1, 2014, and september 30, 2018.Interventions we compared patients with positive and negative respiratory culture results, assessing changes in antibiotic class and antibiotic spectrum index (asi) from the day of sample collection (day 0) through day 7.Results between october 1, 2014, and september 30, 2018, we identified 5,086 patients with hap/vap: 2,952 with positive culture results and 2,134 with negative culture results.All-cause 30-day mortality was 21% for both groups.The mean time from respiratory sample receipt in the laboratory to final respiratory culture result was longer for those with positive (2.9 ± 1.3 days) compared to negative results (2.5 ± 1.3 days; p < .001).The most common pathogens were staphylococcus aureus and pseudomonas aeruginosa.Vancomycin and β-lactam/β-lactamase inhibitors were the most commonly prescribed agents.The decrease in the median asi from 13 to 8 between days 0 and 6 was similar among patients with positive and negative respiratory cultures.Patients with negative cultures were more likely to be off antibiotics from day 3 onward.Conclusions the results of respiratory cultures had only a small influence on antibiotics used during the treatment of hap/vap.The decrease in asi for both groups suggests the integration of antibiotic stewardship principles, including de-escalation, into the care of patients with hap/vap.

Journal: Infection control and hospital epidemiology (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Bridging pico-to-nanonewtons with a ratiometric force probe for monitoring nanoscale polymer physics before damage.

Understanding the transmission of nanoscale forces in the pico-to-nanonewton range is important in polymer physics.While physical approaches have limitations in analyzing the local force distribution in condensed environments, chemical analysis using force probes is promising.However, there are stringent requirements for probing the local forces generated before structural damage.The magnitude of those forces corresponds to the range below covalent bond scission (from 200 p n to several n n) and above thermal fluctuation (several p n).Here, we report a conformationally flexible dual-fluorescence force probe with a theoretically estimated threshold of approximately 100 p n.This probe enables ratiometric analysis of the distribution of local forces in a stretched polymer chain network.Without changing the intrinsic properties of the polymer, the force distribution was reversibly monitored in real time.Chemical control of the probe location demonstrated that the local stress concentration is twice as biased at crosslinkers than at main chains, particularly in a strain-hardening region.Due to the high sensitivity, the percentage of the stressed force probes was estimated to be more than 1000 times higher than the activation rate of a conventional mechanophore.

Journal: Nature communications (2022)
Publication types: Journal Article
Damage integral and other predictive formulas for nonisothermal heating during laser exposure.

Significance physics-based models supply simulated temperature rises to photothermal damage rate models and provide comprehensive risk assessments for laser-induced damage.As the physics-based models continue to be refined, the damage rate models have not advanced.This peculiar lack of improvement is counterintuitive considering the damage integral (ω), originally derived for isothermal heating events, and fails to accurately represent the nonisothermal heating from short laser exposures.Aim derive a nonisothermal form of the damage integral and predict more accurately the damage induced by short laser exposures, as well as identify the role of heating rate in laser damage.Approach from first principles, we derived a version of the damage integral specific to the shape of thermal profiles rather than the square function provided by arrhenius plots.We used previously published threshold thermal profiles, where all nonisothermal frequency factors (anon) solved all ωnon values to unity.Nonisothermal correction factors correct isothermal aiso values.Results the ea values were identical for both the isothermal and nonisothermal conventions.Correction factor values for ωiso ranged from 0.0 (20-s exposures at thermal steady state) to -0.93 (0.05-s exposures).Based on empirical results, we have derived a two-dimensional empirical formula that predicts the heating rate as a function of exposure duration and ambient temperature.Threshold peak temperatures (tpthr) and threshold critical temperatures are mathematically determined without thermal profiles when appropriate ea and anon values are established.Conclusions we have identified a modified damage integral that does not rely on the arrhenius plot and provides a value for the frequency factor (a) that accounts for the nonisothermal nature of short laser exposures.The method, validated in our in vitro retinal model, requires thermal profiles recorded under threshold conditions, such as at minimum visible lesions or the boundary of cell death.The method is a new option for laser damage modelers.

Journal: Journal of biomedical optics (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.
The determinants of the quality of clinical management among diabetic and hypertensive patients in a context of fragility: A cross-sectional survey from Lebanon.

Introduction the management of ncds is a growing challenge in low- and middle-income settings with the increasing prevalence and the associated demands that such conditions make on health systems.Fragile settings both exacerbate the risk of ncds and undermine systems capacity.Lebanon is a setting where strategies to address rising ncds burden have faced particularly acute contextual challenges.Methods we conducted a cross-sectional survey with patients accessing non-communicable disease across 11 primary care centers within the greater beirut and beqaa areas.Response were received from 1,700 patients.We generated a clinical management index score as a measure of quality of care, and scores related to a range of socio-demographic characteristics and other context specific variables.Results significantly higher clinical management index scores (better quality of care) were associated with patients living in the semi-urban/rural context of beqaa (compared to greater beirut), having health insurance coverage, aged above 60, having high levels of educational attainment, and making partial or full payment for their treatment.Relatively lower index scores (poorer quality of care) were associated with syrian nationality (compared to lebanese) and with patients suffering from diabetes or hypertension (compared to comorbid patients).Conclusion the study identified a wide margin for improving quality of ncds care in fragile contexts with particular gaps identified in referral to ophthalmology, accessing all prescribed medication and receiving counseling for smoking cessation.Additionally, findings indicate a number of predictors of comparatively poor quality of care that warrant attention, notably with regard to syrian nationality/legal status, lack of health coverage, seeking free health provision and lower educational attachment.Although these are all relevant risk factors, the findings call on donor agencies, ngos and provider institutions to design targeted programs and activities that especially ensure equitable delivery of services to diabetic and hypertensive patients with compounded vulnerability as a result of a number of these factors.

Journal: Frontiers in public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The association of musculoskeletal complaints and individual and work-related factors with work ability in Chilean white-collar and blue-collar workers.

The maintenance of good work ability has proven to have a positive effect on health, quality of work and productivity.There is little evidence regarding the association between musculoskeletal complaints, individual and work-related factors, and work ability in blue-collar and white-collar workers.methods.A cross-sectional study of hospital and university workers (n= 360) was performed to determine the association between musculoskeletal complaints, individual and work-related factors, and work ability; two multiple linear regression models were created.results.In white-collar workers, musculoskeletal complaints of the dorsal/lumbar region (β= -0.259) and the wrist/hand segment (β= -0.151) were significantly associated with reduced work ability.A higher body mass index (β= -0.227) was also negatively associated with the dependent variable.In blue-collar workers, musculoskeletal complaints of the dorsal/lumbar region (β= -0.317) and the elbow/forearm segment (β= -0.171) were significantly associated with lower work ability.Increased age (β= -0.204) was associated with reduced work ability in this group.No significant correlations were found between work-related factors and work ability.conclusions.Musculoskeletal complaints and individual factors, but not work-related factors, are associated with work ability in chilean blue-collar and white-collar workers.Nevertheless, the variables that explain the change in work ability are different between these groups.

Journal: International journal of occupational safety and ergonomics : JOSE (2022)
Publication types: Journal Article
Full Stereocontrol in α-Glycosidation of 3-Deoxy-d-manno-2-octulosonic Acid (Kdo) Using Macrobicyclic Glycosyl Donors.

We describe a method for the α-selective glycosidation of 3-deoxy-d-manno-2-octulosonic acid (kdo) using a macrobicyclic kdo donor as the precursor of a bridgehead oxocarbenium ion, whose stereoselectivity is not affected by the substrate structure and reaction conditions.Strapping kdo via tethering in the α-configuration at the c1 and c5 positions completely blocked nucleophilic attack to the β-face of the anomeric center by sterically hindering the bicyclic system, realizing full α-selectivity during glycosidation.

Journal: Organic letters (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
An optimized microplate-based method to evaluate complement-dependent hemolysis mediated by intravenous immunoglobulins (IVIG).

Hemolytic reactions can cause serious complications after administration of intravenous immunoglobulin (ivig), due to passive transfer of anti-a and anti-b ig g antibodies (isoagglutinins).A maximum allowable amount of isoagglutinins is established in the us and eu for licensed ivig, as measured by a specified direct hemagglutination test (dhat).Despite this limit, reports of hemolysis have increased over time, raising the question of how well the dhat predicts clinically significant hemolysis.This study was undertaken to develop a microplate-based complement-dependent hemolysis assay (cdha) that reproducibly measures functional hemolytic activity of ivig, for assessment of ivig products.An ivig working reference reagent (nibsc 14/160) was qualified as an assay control and for quantitation purposes.Hemolytic activities of 36 ivig product lots encompassing seven brands and including 6 clinically hemolytic lots were measured.Hemolytic activity varied among ivig product brands, and to a lesser extent, from lot-to-lot for individual brands.Correlation between the cdha and dhat was not robust which may reflect imprecision of the dhat method or additional variables that influence complement-dependent hemolysis after opsonization.In conclusion, the cdha provides a simple, specific, and sensitive tool for ivig product characterization and investigation of hemolytic events by manufacturers, researchers, and regulatory authorities.

Journal: Biologicals : journal of the International Association of Biological Standardization (2022)
Publication types: Journal Article
CCTs as new biomarkers for the prognosis of head and neck squamous cancer.

The chaperonin-containing t-complex protein 1 (cct) subunits participate in diverse diseases.However, little is known about their expression and prognostic values in human head and neck squamous cancer (hnsc).This article aims to evaluate the effects of cct subunits regarding their prognostic values for hnsc.We mined the transcriptional and survival data of ccts in hnsc patients from online databases.A protein-protein interaction network was constructed and a functional enrichment analysis of target genes was performed.We observed that the m rna expression levels of cct1/2/3/4/5/6/7/8 were higher in hnsc tissues than in normal tissues.Survival analysis revealed that the high m rna transcriptional levels of cct3/4/5/6/7/8 were associated with a low overall survival.The expression levels of cct4/7 were correlated with advanced tumor stage.And the overexpression of cct4 was associated with higher n stage of patients.Validation of ccts' differential expression and prognostic values was achieved by the human protein atlas and geo datasets.Mechanistic exploration of cct subunits by the functional enrichment analysis suggests that these genes may influence the hnsc prognosis by regulating pi3k-akt and other pathways.This study implies that cct3/4/6/7/8 are promising biomarkers for the prognosis of hnsc.

Journal: Open medicine (Warsaw, Poland) (2020)
Publication types: Journal Article
Long-Term Analysis of Resilience of the Oral Microbiome in Allogeneic Stem Cell Transplant Recipients.

Stem cell transplantation (sct) is associated with oral microbial dysbiosis.However, long-term longitudinal data are lacking.Therefore, this study aimed to longitudinally assess the oral microbiome in sct patients and to determine if changes are associated with oral mucositis and oral chronic graft-versus-host disease.Fifty allogeneic sct recipients treated in two dutch university hospitals were prospectively followed, starting at pre-sct, weekly during hospitalization, and at 3, 6, 12, and 18 months after sct.Oral rinsing samples were taken, and oral mucositis (who score) and oral chronic graft-versus-host disease (nih score) were assessed.The oral microbiome diversity (shannon index) and composition significantly changed after sct and returned to pre-treatment levels from 3 months after sct.Oral mucositis was associated with a more pronounced decrease in microbial diversity and with several disease-associated genera, such as mycobacterium, staphylococcus, and enterococcus.On the other hand, microbiome diversity and composition were not associated with oral chronic graft-versus-host disease.To conclude, dysbiosis of the oral microbiome occurred directly after sct but recovered after 3 months.Diversity and composition were related to oral mucositis but not to oral chronic graft-versus-host disease.

Journal: Microorganisms (2022)
Publication types: Journal Article
Increased prevalence of left ventricular diastolic dysfunction in adults with repaired coarctation of aorta.

Left ventricular (lv) pressure overload and coronary artery disease are common in patients with coarctation of aorta (coa), and they are risk factors for lv diastolic dysfunction.Patients with coa may have aortic vasculopathy that can result in lv pressure overload even in the absence of hemodynamically significant coa.We therefore hypothesized that patients with mild coa (without hemodynamically significant coa) will have more lv diastolic dysfunction compared to controls.Methods adult patients with mild coa (doppler peak velocity 2 standard deviations above age-specific normative values) between adults with repaired coa and controls.Results of 204 coa and 204 control patients (age 35 ± 12 years), patients with coa had higher septal and lateral e/e' ratio (12 ± 4 vs 9 ± 4, p = 0.009) and (10 ± 3 vs 7 ± 3, p 60 years (82% vs 56%, p = 0.076).Left ventricular mass index (lvmi) was the strongest determinant of e/e' (β = 2.71 per 10 g/m2, standard error = 1.25, p < 0.001).Conclusion lv diastolic dysfunction was common in patients with coa, and the association with lvmi suggests that patients with coa may have ongoing lv pressure overload in the absence of hemodynamically significant re-coarctation.

Journal: International journal of cardiology. Heart & vasculature (2020)
Publication types: Journal Article
Safety and Immunogenicity of Combined DNA-Polyethylenimine and Oral Bacterial Idiotypic Vaccine for Patients with B-Cell Non-Hodgkin Lymphoma: A Pilot Study.

We report, in brief, the results of a phase i, non-randomized study of idiotypic dna vaccination in patients with b-cell non-hodgkin's lymphoma (isrctn31090206).The dna sequence of lymphoma-derived immunoglobulin variable regions was used as a tumor-specific antigen fused to the potato virus x coat protein.A conjugate of plasmid dna with polyethylenimine was used for the intramuscular injections, followed by a boost with an oral live-attenuated salmonellavaccine carrying the same plasmid.The patients with a complete or partial response to previous chemotherapy received one or two courses of vaccination, including four injections at monthly intervals.The vaccine was well tolerated, with low-grade adverse events.The t-cell immune responses were assessed by elispot, at last vaccine, one week and one month post-vaccination, and were detected in 11/14 (78.6%) of the patients.In cases of progression requiring chemotherapy, or the presence of a positive mrd after the first course of vaccination, the patients underwent a second course of vaccination.At the end point, 6/19 vaccinated patients had disease stabilization, while 13/19 were in complete remission.The overall survival was 100% at follow-up, of a median of 2.3 years.

Journal: Cancers (2022)
Publication types: Journal Article
Identifying Valid Algorithms for Number of Lines of Anti-Neoplastic Therapy in the Danish National Patient Registry Among Patients with Advanced Ovarian, Gastric, Renal Cell, Urothelial, and Non-Small Cell Lung Cancer Attending a Danish University Hospital.

To develop algorithms to identify number of lines of anti-neoplastic therapy per patient based on the danish national patient registry (dnpr) and identify which algorithm has the highest percentage agreement with a reference standard of documentation in medical records.Patients and methods we included 179 patients diagnosed between january 1, 2012, and december 31, 2016, with stage ii, iii, or iv urothelial cell carcinoma or stage iii or iv epithelial ovarian cancer, gastric adenocarcinoma, renal cell carcinoma, or non-small cell lung cancer (nsclc).We developed two algorithms for number of lines of anti-neoplastic therapy based on dates and treatment codes (eg, "treatment with cisplatin" or "cytostatic treatment") in the dnpr.First, to denote a change in line of therapy the "time-based algorithm" used the number of days between consecutive administrations.Second, the "drug-based algorithm" used information on drug names if available or the number of days between consecutive administrations if no drug names were specified.We calculated the percentage agreement between the algorithms setting the number of allowed days between consecutive administrations from 28 to 50 and the reference standard - information on anti-neoplastic therapy drugs abstracted from medical records and subsequently coded according to lines of anti-neoplastic therapy.Results for the "time-based algorithm", the highest percentage agreement with the reference standard was found when using <45 days between consecutive administrations (67.6%; 95% ci: 60.1-73.8%).However, the percentage agreement was higher for the "drug-based algorithm" using <45 days between consecutive administrations for registrations where the drug name was unspecified (90.5%; 95% ci: 85.0-93.7%).Conclusion the algorithm for number of lines of anti-neoplastic therapy that had the highest percentage agreement with the reference standard (medical records) incorporated both registration of specific drug names and <45 days between consecutive administrations if the drug name was unspecified in routinely recorded data from dnpr.

Journal: Clinical epidemiology (2022)
Publication types: Journal Article
Design, Synthesis, and Structure-Activity Relationship of Quinazolinone Derivatives as Potential Fungicides.

Plant diseases caused by phytopathogenic fungi reduce the yield and quality of crops.To develop novel antifungal agents, we designed and synthesized eight series of quinazolinone derivatives and evaluated their anti-phytopathogenic fungal activity.The bioassay results revealed that compounds kzl-15,kzl-22,5b,6b,6c,8e, and8fexhibited remarkable antifungal activityin vitro.Especially, compound6cdisplayed the highest bioactivity against sclerotinia sclerotiorum,pellicularia sasakii,fusarium graminearum, and fusarium oxysporum, displaying appreciable ic50values (50% inhibitory concentration) of 2.46, 2.94, 6.03, and 11.9 μg/m l, respectively.A further mechanism interrogation revealed abnormal mycelia, damaged organelles, and changed permeability of cell membranes in s.Sclerotiorumtreated with compound6c.In addition, thein vivobioassay indicated that compound6cpossessed comparable curative and protective effects (87.3 and 90.7%, respectively) to the positive control azoxystrobin (89.5 and 91.2%, respectively) at 100 μg/m l concentration against s.Sclerotiorum.This work validated the potential of compound6cas a new and promising fungicide candidate, contributing to the exploration of potent antifungal agents.

Journal: Journal of agricultural and food chemistry (2021)
Publication types: Journal Article