syedzayyan/paper_mill_benchmark huggingface dataset:
The performance of a new shock advisory algorithm to reduce interruptions during CPR.

To explore a new algorithm and strategy for rhythm analysis during chest compressions (ccs), and to improve the efficiency of cardiopulmonary resuscitation (cpr) by minimizing interruptions.Methods the clinical data and ecg of patients with sudden cardiac arrest (ca) from three hospitals in china were collected with philips mrx monitor/defibrillators.The length of each analyzed ecg segment was 23 s, the first 11.5 s was selected to contain cpr compressions, the next 5 s had no compressions, and the last 6.5 s had no requirement.Three experienced emergency doctors annotated the ecg segments without compression artifacts.A two-step analysis through cpr (atc) algorithm was applied to the selected data.The first step was analysis during chest compressions.If a shockable rhythm was not detected, compression-free analysis followed.The results of the atc algorithm were compared with the annotations by the physicians, to determine the sensitivity and specificity of the algorithm.Results in total 166 ca patients were included with 100 out-of-hospital cardiac arrest (ohca) patients and 66 in-hospital cardiac arrest (ihca) patients.A total of 1578 ecg segments were analyzed, including 115 (7.3%) shockable rhythms, 1278 (81.0%) non-shockable rhythms, and 185 (11.7%) intermediate/unknown rhythms.The specificity of all non-shockable rhythms was 99.8% at the end of chest compressions, and 99.5% after analysis without compression artifact.70.5% of ventricular fibrillation (vf) rhythms were detected by the end of chest compressions.After the cc-free analysis, 93.6% of vf was identified.Conclusion the atc algorithm achieved sensitivity of 93.6% and specificity of 99.5% after the two-step analysis, and 70.5% of the patients with shockable rhythms did not require cc-free analysis.Such an approach has the potential to substantially reduce cc interruptions when identifying shockable rhythms.

Journal: Resuscitation (2019)
Publication types: Journal Article;Multicenter Study;Research Support, Non-U.S. Gov't
The current standing of autologous haematopoietic stem cell transplantation for the treatment of multiple sclerosis.

Autologous haematopoietic stem cell transplantation (a hsct) is gaining traction as a valuable treatment option for patients affected by severe multiple sclerosis (ms), particularly the relapsing-remitting form.We describe the current literature in terms of clinical trials, observational and retrospective studies, as well as immune reconstitution following transplantation, with a focus on the conditioning regimens used for transplantation.The evidence base predominantly consists of non-randomised, uncontrolled clinical trials or data from retrospective or observational cohorts, i.e.Very few randomised or controlled trials.Most often, intermediate-intensity conditioning regimens are used, with promising results from both myeloablative and lymphoablative strategies, as well as from regimens that are low and high intensity.Efficacy of transplantation, which is likely secondary to immune reconstitution and restored immune tolerance, is, therefore, not clearly dependent on the intensity of the conditioning regimen.However, the conditioning regimen may well influence the immune response to transplantation.Heterogeneity of conditioning regimens among studies hinders synthesis of the articles assessing post-a hsct immune system changes.Factors associated with better outcomes were lower kurtzke expanded disability status scale, relapsing-remitting ms, younger age, and shorter disease duration at baseline, which supports the guidance for patient selection proposed by the european society for blood and marrow transplantation.Interestingly, promising outcomes were described for patients with secondary progressive ms by some studies, which may be worth taking into account when considering treatment options for patients with active, progressive disease.Of note, a significant proportion of patients develop autoimmune disease following transplantation, with alemtuzumab-containing regimens associated with the highest incidence.

Journal: Journal of neurology (2022)
Publication types: Journal Article
Computational Design of Anticorrosion Properties of Novel, Low-Molecular Weight Schiff Bases.

Due to the many economic consequences and technological problems caused by the corrosion process, its inhibition is one of the most important aspects of ongoing research.Computer methods, i.e., density functional theory (dft) methods, are of great importance to the large-scale research being conducted which allows the evaluation of the corrosion inhibition performance without conducting time-consuming, long-term and expensive experimental measurements.In this study, new corrosion inhibitors were designed in three corrosion environments on the basis of their homo and lumo orbital energies-the energy difference between them and their dipole moment.In addition, their interactions with the fe and cu surface were modelled on the basis of the number of electrons transferred during the formation of the protective adsorption layer (δn) and the initial energy between inhibitor molecule and protected metal surface (δψ).The obtained results indicate that, among the aliphatic investigated schiff bases, the n-methylpropan-1-imine (n-mp(1)i) molecule would theoretically have the highest corrosion inhibition efficiency mainly due to its high ehomovalue, relatively low elumovalue, high chemical reactivity and high polarity.

Journal: Materials (Basel, Switzerland) (2022)
Publication types: Journal Article
Incorporation ofin situgenerated 3,3'-(sulfane-diyl)bis-(1-methyl-1,3-imidazolidine-2-thione) into a one-dimensional CuIcoordination polymer with sulfur-bridged {CuI4S10}ncentral cores.

The reaction of [cu(ch3cn)4](bf4) with 1-methyl-1,3-imidazolidine-2-thione {sc3h4(nme)nh}, under aerobic conditions at room temperature, yielded an unusual one-dimensional coordination polymer, namely,catena-poly[[[(1-meth-yl-1,3-imidazolidine-2-thione-κs)copper(i)]-μ-(1-methyl-1,3-imidazolidine-2-thione)-κ2s:s-copper(i)-μ-[3,3'-(sulfanedi-yl)bis-(1-methyl-1,3-imidazolidine-2-thione)]-κ5s,s',s'':s,s''] bis-(tetra-fluorido-borate)], {[cu2(c4h8n2s)2(c8h14n4s3)](bf4)2}nor [cu4(κ5:l1-n-s-n-l1)2(κ1:l1-nh)2(κ2:l1-nh)2]n(bf4)4n1[l1= sc3h4(nme)nh] with sulfur-bridged {cu i4s10}ncentral cores.Thein situgenerated bis-(1-methyl-1,3-imidazolidinyl-2-thione) sulfide [{sc3h4(nme)nsn(nme)c3h4s; abbrev.l1-n-s-n-l1] ligand, in combin-ation with 1-methyl-1,3-imidazolidine-2-thione (l1-nh) ligands, construct this coordination polymer.Each cu iion is bonded to four sulfur donor atoms in a distorted tetra-hedral geometry and the formation of this polymer solely by sulfur donor atoms with {cu i4s10}ncentral cores, is the first such example in copper-heterocyclic-2-thione chemistry.

Journal: Acta crystallographica. Section E, Crystallographic communications (2022)
Publication types: Journal Article
Being heard - Supporting person-centred communication in paediatric care using augmentative and alternative communication as universal design: A position paper.

Person-centred care, with its central focus on the patient in partnership with healthcare practitioners, is considered to be the contemporary gold standard of care.This type of care implies effective communication from and by both the patient and the healthcare practitioner.This is often problematic in the case of the paediatric population, because of the many communicative challenges that may arise due to the child's developmental level, illness and distress, linguistic competency and disabilities.The principle of universal design put forth in conventions and legislation means that the design of products and services should be usable by all people, to the greatest extent possible.Augmentative and alternative communication encompasses strategies, for example pictures and apps, that are typically used with people with communication disability.In this position paper, we argue for the universal use of augmentative and alternative communication to support person-centred communication and care for children, regardless of age or potential disability.Clinical examples are shared from three different paediatric care settings where pictorial supports were applied universally.Interviews were conducted with children and adolescents (with and without disabilities), parents and healthcare practitioners, and the principles of universal design were used as a framework to demonstrate how person-centred communication is supported in paediatric care.

Journal: Nursing inquiry (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Epidemiologic characteristics of SARS-CoV-2 in Wuhan, other regions of China, and globally based on data gathered from January 2020 to February 2021.

This observation study examines coronavirus disease 2019 (covid-19) data from outbreak and other sites in china and worldwide in order to examine the epidemiological pattern of covid-19 before the acquisition of immunity through widespread vaccination and infection.Covid-19-related morbidity and mortality data for january 2020 to february 2021 were obtained from the chinese center for disease control and prevention, hubei provincial center for disease control and prevention, and the world health organization.The number of cases was logarithmically transformed for comparison of the rate of increase or decrease with time across areas.From january to february 2020, the number of new confirmed cases in wuhan grew substantially but returned to zero by may 2020.In other parts of china, the rate of decrease was lower than that in wuhan, and the mortality rate was lower outside wuhan (1.93%) than in wuhan (7.68%).The influenza trends were similar to those of covid-19, but the mortality rate of influenza was much lower (0.011%) than that of covid-19.After the early stage, similar increase in the incidence rate with time was observed globally, although the total number of cases differed between regions.The outbreak severe acute respiratory syndrome coronavirus 2 strain in wuhan had low epidemic intensity and high virulence, but the epidemiological characteristics of severe acute respiratory syndrome coronavirus 2 may not be associated with race, geography, or economic status.Importantly, more effective prevention and control measures and vaccines should be applied for controlling the variants.

Journal: Medicine (2022)
Publication types: Journal Article;Observational Study
Functionalization of Mono- and Bimetallic MIL-100(Al,Fe) MOFs by Ethylenediamine: Postfunctionalization, Brønsted Acido-Basicity, and Unusual CO2Sorption Behavior.

The metal sites of mil-100(fe), mil-100(fe,al), and mil-100(al) metal-organic frameworks (mofs) were decorated with ethylenediamine (en).Interestingly, the al-containing mofs presented hierarchized porosity, and their structural integrity was maintained upon functionalization.Solution and solid-state nmr confirmed the grafting efficiency in the case of mil-100(al) and the presence of a free amine group.It was shown that mil-100(al) can be functionalized by only one en molecule in each trimeric al3o cluster unit, whereas the other two aluminum sites are occupied by a hydroxyl and a water molecule.The -nh2sites of the grafted ethylenediamine can be used for further postfunctionalization through amine chemistry and are responsible for the basicity of the functionalized material as well as increased affinity for co2.Furthermore, the presence of coordinated water molecules on the al-mof is responsible for simultaneous brønsted acidity.Finally, the al-containing mofs show an unusual carbon dioxide sorption mechanism at high pressures that distinguishes those materials from their iron and chromium counterparts and is suspected to be due to the presence of polarized al-oh bonds.

Journal: Inorganic chemistry (2021)
Publication types: Journal Article
Earlier snow melt and reduced summer precipitation alter floral traits important to pollination.

Climate change can cause changes in expression of organismal traits that influence fitness.In flowering plants, floral traits can respond to drought, and that phenotypic plasticity has the potential to affect pollination and plant reproductive success.Global climate change is leading to earlier snow melt in snow-dominated ecosystems as well as affecting precipitation during the growing season, but the effects of snow melt timing on floral morphology and rewards remain unknown.We conducted crossed manipulations of spring snow melt timing (early vs.Control) and summer monsoon precipitation (addition, control, and reduction) that mimicked recent natural variation, and examined plastic responses in floral traits of ipomopsis aggregata over 3 years in the rocky mountains.We tested whether increased summer precipitation compensated for earlier snow melt, and if plasticity was associated with changes in soil moisture and/or leaf gas exchange.Lower summer precipitation decreased corolla length, style length, corolla width, sepal width, and nectar production, and increased nectar concentration.Earlier snow melt (taking into account natural and experimental variation) had the same effects on those traits and decreased inflorescence height.The effect of reduced summer precipitation was stronger in earlier snow melt years for corolla length and sepal width.Trait reductions were explained by drier soil during the flowering period, but this effect was only partially explained by how drier soils affected plant water stress, as measured by leaf gas exchange.We predicted the effects of plastic trait changes on pollinator visitation rates, pollination success, and seed production using prior studies on i.Aggregata.The largest predicted effect of drier soil on relative fitness components via plasticity was a decrease in male fitness caused by reduced pollinator rewards (nectar production).Early snow melt and reduced precipitation are strong drivers of phenotypic plasticity, and both should be considered when predicting effects of climate change on plant traits in snow-dominated ecosystems.

Journal: Global change biology (2022)
Publication types: Journal Article
Immunostimulation and Coagulopathy in COVID-19 Compared to Patients With H1N1 Pneumonia or Bacterial Sepsis.

/aim multiple reports from all over the world link covid-19 with endothelial/coagulation disorders as well as a dysregulated immune response.This study tested the hypothesis that immunostimulation will be greater in covid-19 patients than in patients with h1n1 infection or bacterial sepsis.Also, whether an increase in immune stimulation will be accompanied by a more severely affected endothelium/coagulation system was examined.Patients and methods twenty-three septic patients, admitted in the intensive care unit (icu), were enrolled (9 with sars-co v-2, 5 with h1n1 pneumonia, 9 with bacterial sepsis).Myeloperoxidase (mpo) activity along with certain endothelial/coagulation factors were assessed on admission (time point 1) and at either improvement or deterioration (time point 2).Results mpo levels were significantly higher in covid-19 patients compared to both other groups.Furthermore, in patients with covid-19, v wf levels did not differ significantly, f viii levels were lower while adamts-13 activity was higher compared to patients with h1n1 pneumonia and bacterial sepsis (a trend in the latter).Conclusion increased immunostimulation was noted in covid-19 patients compared to other septic patients; however, this was not accompanied by greater disturbance of the clotting system and/or more severe endothelial injury.

Journal: In vivo (Athens, Greece) (2022)
Publication types: Journal Article
Emergency medical service utilization among acute ischemic stroke patients in Beijing: An observational study.

To investigate emergency medical service (ems) utilization and its associated factors in patients with acute ischemic stroke (ais), and further explore the urban-rural differences.Methods medical records for ais in all emergency departments in beijing were obtained from the beijing emergency care database from january 2018 to december 2021.Ems utilization was described and factors associated with ems use were examined by multivariable logistic regression models with the generalized estimating equations.Results were compared between urban and rural districts.Results a total of 24,296 ais patients were included in the analysis, and 11,190 (46.1%) were transported to hospitals by ems.The percentage of ems usage in urban areas was significantly higher than that in rural areas (53.6 vs.34.4%,p< 0.001).From 2018 to 2021, ems utilization was on the increase (p-value for trend <0.001) with a higher average annual growth rate in rural areas (12.6%) than in urban (6.4%).Factors associated with ems utilization were age (or: 1.20 per 10-year increase, 95% ci: 1.17-1.23), nihss scores, off-hour arrival (or: 1.32, 95% ci: 1.23-1.37), treatment in tertiary hospitals (or: 1.75, 95% ci: 1.60-1.92), and possessing comorbidities such as coronary artery disease (or: 1.15, 95% ci: 1.17-1.24), atrial fibrillation (or: 1.56, 95% ci: 1.41-1.73), prior stroke (or: 0.84, 95% ci: 0.78-0.90) or dyslipidemia (or: 0.78, 95% ci: 0.71-0.85).Conclusion this study demonstrated an inadequate use of ems among ais patients in beijing, especially in rural areas, and revealed several associated factors.Enhanced education programs and ems accessibility are necessary particularly for high-risk individuals and regions.

Journal: Frontiers in neurology (2022)
Publication types: Journal Article
Incidence of stroke and mortality due to stroke after acute coronary syndrome.

S stroke is a known complication after myocardial infarction (mi) and it is associated with increased mortality.We aimed to establish the true cumulative incidence of stroke and its subtypes and the associated mortality in a contemporary setting among patients treated for acute coronary syndrome (acs).Materials and methods a retrospective registry study based on the data of 8,049 consecutive patients treated for acs in a sole provider of specialized cardiac and neurologic care for a catchment area of over 0.5 million residents between 2007 and 2018.Incident strokes and their subtypes were identified by in-depth review of written hospital records, hospital discharge registry data and causes of death registry data maintained by statistics finland up until december 31st2020.Results during a median follow-up of 5.8 years (iqr 3.2-9.0) 570 acs patients suffered a stroke.The cumulative incidences of stroke for first week, first month, first year and at thirteen years were: 0.8 %, 1.1 %, 2.2 % and 10.3 %.In long-term, patients with different acs subtypes had similar cumulative incidence of strokes, although the incidence of in-hospital strokes was highest among myocardial infarction patients.Stroke mortality rate was 32.5 % (n=185/570).The majority (88.8 %) of strokes were ischemic with the proportion being most substantial for in-hospital strokes (95.6 %).Conclusions the risk of stroke among patients treated for acs and the related mortality are still notable in a contemporary setting.A distinctive majority of strokes following acs were ischemic especially early on after acs.

Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (2022)
Publication types: Journal Article
Modeling water quantity and quality for a typical agricultural plain basin of northern China by a coupled model.

Water crisis across the globe has placed high pressure on social development due to the need to balance the water consumption between sustainable economy and functioning ecosystem.Integrated process-based modeling has been reported as an effective tool to better understand the complex mechanisms of water issues on a basin scale.Considering that it is still relatively difficult to simulate the water quantity-quality processes simultaneously, this study proposed an integrated modeling framework by coupling a hydrological model with a water quality model.Taking the xiaoqing river basin in the shandong province of northern china as an example, this study coupled a distributed hydrological model, swat, with a one-dimensional hydrodynamic-water quality model, hec-ras, to investigate its ability to simulate water quality and quality at the basin scale.The coupling of the two models adopted the "output-input" scheme, where the runoff modeling results from swat are input into hec-ras for hydrodynamic and water quality simulations of the river channel.The results show that the swat model can adequately reproduce runoff with accepted accuracy for the calibration and validation periods with acceptable r2and nash-sutcliffe coefficients for the two hydrological stations.Further analysis also shows that the coupled model can simulate the concentration of ammonia nitrogen (nh4-n) and the chemical oxygen demand (cod) in the middle and upper stream of the river for both low and high flow periods.The coupling of the hydrological and hydraulic models in this study provides a good tool for identifying the spatial patterns of the water pollutants over the basin and, thus, helps simplify precision water management.

Journal: The Science of the total environment (2021)
Publication types: Journal Article
Heart rate as a proxy for estimating oxygen consumption rates in loggerhead turtles (Caretta caretta).

Heart rates of air-breathing diving animals can change on a short time scale due to the diving response during submergence.Heart rate is used frequently as a proxy for indirectly estimating metabolic rates on a fine time scale.However, most studies to date have been conducted on endothermic diving animals, and the relationships between metabolic rates and heart rates in ectothermic diving animals have not been well studied.Sea turtles are unique model organisms of diving ectotherms because they spend most of their life in the ocean and perform deep and/or long dives.In this study, we examined the relationship between heart rates and metabolic rates in captive loggerhead turtles, caretta caretta, to estimate oxygen consumption rates during each dive based on heart rates.The oxygen consumption rates (v̇o2: ml o2 min-1 kg-1) and average heart rates (f h: beats min-1) were measured simultaneously in indoor tanks at water temperatures of 15-25°c.Our results showed that oxygen consumption rate was affected by heart rate and water temperature in loggerhead turtles.Based on the collected data, we formulated the model equation as v̇o2=0.0124f h+0.0047tw - 0.0791.The equation can be used for estimating fine-scaled field metabolic rates in free-ranging loggerhead turtles.The results of this study will contribute to future comparative studies of the physiological states of ectothermic diving animals.

Journal: Biology open (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't