syedzayyan/paper_mill_benchmark huggingface dataset:
Study on the Diagnostic Value of Neuroelectrophysiological Examination in Patients with Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (als) is a progressive neurodegenerative disease with unknown causes involving upper and lower motor neurons.Our study aimed to explore the diagnostic value of neuroelectrophysiological examination in patients with amyotrophic lateral sclerosis.Methods.A total of 64 patients admitted to our hospital from january 2014 to december 2020 were selected as als group.Additionally, 64 normal healthy people in the same period were selected as the control group.Electrophysiological tests were performed on all personnel involved in the study, and the results and parameter changes of different personnel were compared and analyzed.Results.There was a statistical difference between the emg data of clinically confirmed als and the proposed als and possible als ( p &lt; 0.05 ).The abnormality of confirmed als was particularly obvious, and the overall abnormal rate of emg in als was 85%.The cmct of the upper and lower limbs of clinically diagnosed als, suspected als, and possible als were longer than that of the normal group ( p &lt; 0.05 ).There was no significant statistical difference between clinically diagnosed als and suspected als ( p &gt; 0.05 ), and there was a difference between clinically diagnosed als and possible als ( p &lt; 0.05 ).In als group, the frequency of f wave decreased, which may be related to the involvement of f wave conduction pathway and the degree of lower motor neuron involvement ( p &lt; 0.05 ).In addition, the amplitudes of f and h waves increased, which was related to the involvement of upper motor neurons ( p &lt; 0.05 ).In als group, scv was hardly involved, and cmap decreased significantly, which was positively correlated with the degree of muscular atrophy and muscle strength decline ( p &lt; 0.05 ).The sensitivity of electrophysiological detection was 76.56%, the specificity was 78.33%, and the auc was 0.8578.Conclusion.Patients with clinically suspected als should undergo electrophysiological testing as soon as possible, which is conducive to the early diagnosis and differential diagnosis of als.This trial is registered with chi ctr2100046535.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Study on Risk Factors Related to Intrauterine Adhesion Based on Meta-Analysis

Intrauterine adhesion (iua) is a severe complication that occurs following abortion.To evaluate the related risk factors of uterine cavity adhesion by meta-analysis.Methods.The research literature on the influencing factors of patients with intrauterine adhesions published from january 2010 to december 2020 in pub med, embase, cochrane library, web of science, cnki, wanfang data, vip, and cbm were retrieved by computer.Two evaluators independently screened the literature, extracted the data, and evaluated the treatment according to the inclusion and exclusion criteria and then analyzed it with revman5.3 software.Results.Finally, 12 literatures were included, with a total sample size of 2341 cases.The results of meta-analysis showed that pelvic inflammation ( p = 0.05 ), negative pressure during uterine suction ( p &lt; 0.0001 ), and uterine suction time ( p &lt; 0.00001 ) were the risk factors for uterine cavity adhesion.The combined or and 95% ci of each factor were 2.05 (1.24, 3.38), 125.61 (67.35, 183.87), and 4.52 (4.21, 4.84), respectively.However, the number of pregnancies, the number of curettages, the average number of births, abortion, myomectomy, menstrual abnormalities, and infertility have little impact on the occurrence of intrauterine adhesions ( p &gt; 0.05 ).Conclusion.Pelvic inflammatory disease, negative pressure during uterine suction and uterine suction time are the risk factors leading to uterine cavity adhesion.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Meta-Analysis;
Study on Psychological Stress Response and Intervention Countermeasures of Exposed Population under Sudden Public Health Crisis

After the occurrence of public health emergencies, people will have a series of physiological reactions, which will develop into psychological stress disorder in serious cases.Based on this, the purpose of this study is to analyze the psychological stress response and intervention countermeasures of exposed people under sudden public health crisis.Objective .To explore the psychological stress response and intervention countermeasures of exposed population under sudden public health crisis.Methods .A total of 400 people under the sudden public health crisis that bring about serious damage to public health, mass diseases of unknown causes, major food and occupational poisoning, and other events that seriously affect public health from december 2020 to december 2021 were selected as the subjects of the study.It was randomly and equally divided into two groups to take different intervention measures, the control group was given routine public health crisis intervention measures, and the research group was given comprehensive intervention.The metabolism, social function defects, health symptoms, psychological status, quality of life, sleep quality, and stress reaction were compared between the two groups.Results .The rate of good metabolism in the research group was significantly higher than that in the control group ( p &lt; 0.05).After intervention, the scores of social disability screening schedule (sdss) and symptom checklist 90 (scl‐90) decreased in both groups, and the scores of sdss and scl‐90 in the research group were lower than those in the control group.After intervention, the scores of self‐rating depression scale and self‐rating anxiety scale in the two groups decreased, and the scores of self‐rating depression scale and self‐rating anxiety scale in the research group were lower than those in the control group ( p &lt; 0.05).The sleep quality of the research group was better than that of the control group ( p &lt; 0.05).The stress response indexes such as cortisol, blood glucose, and c‐reactive protein in the two groups were decreased after intervention.The stress response indexes such as cortisol, blood glucose, and c‐reactive protein in the research group were lower than those in the control group ( p &lt; 0.05).Conclusion .Giving that comprehensive intervention measures to people exposed to sudden public health crisis can effectively relax their stress response, reinvigorate their quality of life and sleep, reduce depression and anxiety, and improve their metabolism, therefore, in the case of the outbreak of public health crisis in the future, it is worth applying for reference and popularizing.

Journal: BioMed Research International (2022)
Publication types: Clinical Study;
Study on Management of Blood Transfusion Therapy in Patients with Hereditary Spherocytosis

Hereditary spherocytosis (hs) is a chronic hemolytic disorder caused by inherited defects in the red blood cell membrane.This study discusses the treatment strategy for the decline in hemoglobin level in three hs probands with moderately severe or severe hemolysis and summarizes the appropriate laboratory tests that help improve clinical management of blood transfusion in hs patients.Three probands who were diagnosed with hs in our hospital and their family members were included in this study.Clinical data of the three families were reviewed to summarize their hematopoietic characteristics.Dna from all family members of the 3 hs probands was amplified by polymerase chain reaction (pcr) and sequenced by the sanger method to assess genetic relation for hs.Based on the sequencing results, the type of mutated membrane protein in each proband was analyzed using the eosin-5 ′ -maleimide (ema) binding test and sodium dodecyl sulfate polyacrylamide gel electrophoresis (sds-page).The hemoglobin level was reduced in all 3 probands after different levels of infection.The fluorescence of ema-labeled red blood cell (rbc) was decreased.Dna sequencing showed that his54pro, leu1858val, and 6531-12c&gt;t compound heterozygous mutations were present in the spta1 gene of patient i-1, arg344gln and c.609+86g&gt;a heterozygous mutations were present in the slc4a1 gene of patient ii-1, and leu2032pro homozygous mutation was present in the sptb gene of patient iii-1.Sds-page results demonstrated that the concentration of band 3 was reduced in ii-1, whereas the levels of the corresponding mutant proteins in the other probands were unchanged.The family members of the respective patients presented mutations in major genes causing hs.The leu2032pro mutation identified in patient iii-1 is a new missense mutation of the sptb gene in the chinese population that has never been reported in literature previously.The presence or absence of acute or chronic infections is a critical deciding factor for the treatment and clinical management of hs patient via blood transfusion.For patients with infections, hemoglobin concentration can be restored once the infection is controlled, thus obviating the need for proper infection control before blood transfusion.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Study on Factors Associated with High Myopia CNV in Aqueous Humor and Serum

The objective is to investigate the relationship and correlation between pedf and tgf‐ β in aqueous humor and serum and high myopia cnv lesions.Methods .For each group of patients (namely, group a: patients with high myopia cnv (m cnv); group b: patients with high myopia without cnv; group c: patients with cnv caused by other eye diseases; and group d (control group): patients with simple cataract (without cnv and high myopia)), 20 patients were collected.A total of 40 patients have been collected since the beginning of the study in december 2020, including 7 patients in group a, 13 patients in group b, 10 patients in group c, and 10 patients in group d.Serum and aqueous humor samples were collected, and pedf and tgf‐ β levels in serum and aqueous humor were detected by enzyme‐linked immunosorbent assay (elisa).Spss 26.0 statistical software was used to process the data.Independent sample t ‐test was used to compare the data of the same factor in the same group between serum and aqueous humor.Comparisons of the same factors between different groups were performed using a one‐way analysis of variance (anova).Correlation analysis was conducted by the pearson correlation coefficient test.P &lt; 0.05 indicated that the difference was statistically significant.Results .There were no significant differences in age, gender, and course of disease among all groups ( p &gt; 0.05).The concentration of pedf in aqueous humor in group a and group c was higher than that in group b and group d.There was no significant correlation between serum pedf content and the above‐mentioned diseases.The concentration of tgf‐ β in aqueous humor in groups a, b, and c was significantly higher than that in group d.However, there was no significant correlation between tgf‐ β content in serum and the above‐mentioned diseases.There was no significant correlation between aqueous humor and serum pedf.There was no significant correlation between the content of tgf‐ β in aqueous humor and serum.Conclusion .Tgf‐ β in aqueous humor may be involved in the development of high myopia and intraocular cnv disease.However, pedf in aqueous humor may be involved in the development of intraocular cnv disease and has no significant correlation with high myopia.At the same time, tgf‐ β and pedf in serum had no significant correlation with high myopia and intraocular cnv disease.There was no significant correlation between the concentrations of tgf‐ β and pedf in aqueous humor and serum.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Study of Vertebral Artery Dissection by Ultrasound Superb Microvascular Imaging Based on Deep Neural Network Model

To assess the diagnostic value of ultrasound superb microvascular imaging (smi) and versus doppler ultrasound (tcd) for microvascular structure and aerodynamic changes in vertebral artery dissection (vad).In this paper, we firstly simulate the process of clinician recognition of vertebral artery dissection and propose a combination of a priori shape information of vertebral artery dissection and deep folly convolutional networks (dfcns) for ivus.In this paper, 15 patients with vertebral artery dissection confirmed by smi, digital subtraction angiography (dsa), or computed tomography angiography (cta) from 2020 to 2021 were selected, and the true and false lumen diameters, peak systolic flow velocity (psv), end-diastolic flow velocity (edv) and psv, edv, and plasticity index (pi) of the intracranial vertebral artery were measured.Among the 15 patients with vad, 4 (27%, 4/15) had trauma-induced secondary vertebral artery entrapment and 11 (73%, 11/15) had spontaneous entrapment without a clear cause.According to the structural characteristics of the vessels, there were 11 cases (73%, 11/15) of double-lumen, intramural hematoma, and vertebral artery dissection aneurysm, and 11 cases (73%, 11/15) of v1 segment.Smi not only provides an objective assessment of the vascular morphology and aerodynamic changes in vad but also, in combination with tcd, can further determine the opening of the traffic branches in the posterior circulation, providing reliable information for the early diagnosis and treatment of microvascular dissection of the vertebral artery.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Status Quo of Occupational Identity of Nursing Staff in Rehabilitation Department and Its Relationship with Work Stressors

Due to the continuous progress of social economy, medical and health technology and the development of disciplines have shown a trend of rapid development.In the current medical environment, quality nursing services are constantly promoted.Nursing staff are dedicated to their work to the best of their ability.Meanwhile, they should be rewarded with corresponding happiness and joy in their work.This study starts from the perspective of nursing management and psychology.On this basis, it investigates the occupational identity and work stress status of nursing staff.At the same time, the data are analyzed, and the relationship between occupational identity and work pressure is analyzed.This article provides a certain theoretical basis and support for the decision‐making of relevant nursing managers, and also makes efforts to improve the professional identity and work happiness of nursing staff.In this study, which surveyed 596 rehabilitation nurses, the nurses’ total occupational stress score was 74.52, with an average score of 2.12 points.The overall score for professional identity was 102.00, with an average score of 3.40 points.This belonged to the medium level.It showed that the occupational pressure of nurses should be paid attention to by relevant managers.Two of the five dimensions with the highest scores were occupational social support and occupational self‐reflection.A negative correlation was found between occupational stress and its dimensions and occupational identity and its dimensions ( p &lt; 0.01).

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Statistical Analysis of the People Fully Vaccinated against COVID-19 in Two Different Regions

Motivation.Currently, the covid-19 pandemic represents a critical issue all over the world.On may 11, 2020, at 05 : 41 gmt, approximately 0.28 million individuals had perished because of the covid-19 pandemic, and the figure is continuously growing rapidly.Unfortunately, millions of people have died due to this pandemic.As a result, this issue forced governments and other corresponding organizations to take significant action, such as the lockdown and vaccinations.Furthermore, scientists have developed several vaccinations, and the world health organization (who) has urged governments and people to get vaccinated to eradicate this pandemic.Consequently, the findings of any scientific research into this phenomenon are highly interesting.Problem statement.To enhance individual protection, it is now critical to analyze and compare the percentage of people fully vaccinated against covid-19.It is constantly of interest in the field of big data science and other related disciplines to provide the best analysis and modeling of covid-19 data.Methodology.Through this paper, we aimed to compare individuals who have been completely vaccinated against covid-19 in two locations: north american countries and arabian peninsula countries.Simple techniques for comparing individuals who have been completely vaccinated against covid-19 have been applied, which may be used to generate the foundation for conclusions.Most significantly, a modern statistical model was created to present the best assessment of individuals completely vaccinated against covid-19 data in nations in north america and the arabian peninsula.Some of the suggested statistical model features were proposed.Furthermore, the estimate of the model parameters was driven using the maximum likelihood estimation method.Results.The flexibility provided by the proposed statistical model is useful for describing the percentage of the individuals completely vaccinated against covid-19, which provides a close fit with the covid-19 data.Implications.The proposed statistical model can be used for statistics and generate new statistical distributions that can be used to compare and predict the process of people’s willingness to vaccinate and take the vaccine to try to eliminate covid-19.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Sports Rehabilitation Treatment of Medical Information in Tertiary Hospitals Based on Computer Machine Learning

The processing and analysis of medical rehabilitation information data in tertiary hospitals is a hot research topic.Combining medical data analysis with machine learning algorithms to improve data mining efficiency is a problem that needs to be solved at present.This paper proposes an autonomous perception model of sports medicine rehabilitation equipment based on a deep learning algorithm for sports medical rehabilitation data.Methods.This paper cites a deep learning multi-dimensional perception model for medical rehabilitation equipment autonomous perception.The model utilizes the automatic overhaul of medical rehabilitation equipment based on deep belief networks.This paper extracts features through a multi-layer neural network and obtains fault location results of medical rehabilitation equipment through softmax.Results.In similarity prediction, the accuracy rate of the first three kinds of feedback containing the target answer is 77%.The accuracy rate of the target answers included in the top five kinds of feedback was 92%.Conclusion.In this study, it is feasible to apply deep learning to the quality control information system of sports rehabilitation medical equipment.This improves the management efficiency of medical rehabilitation equipment to a certain extent.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Simulation of Mechanical Heart Valve Dysfunction and the Non-Newtonian Blood Model Approach

The mechanical heart valve (mhv) is commonly used for the treatment of cardiovascular diseases.Nonphysiological hemodynamic in the mhv may cause hemolysis, platelet activation, and an increased risk of thromboembolism.Thromboembolism may cause severe complications and valve dysfunction.This paper thoroughly reviewed the simulation of physical quantities (velocity distribution, vortex formation, and shear stress) in healthy and dysfunctional mhv and reviewed the non-newtonian blood flow characteristics in mhv.In the mhv numerical study, the dysfunction will affect the simulation results, increase the pressure gradient and shear stress, and change the blood flow patterns, increasing the risks of hemolysis and platelet activation.The blood flow passes downstream and has obvious recirculation and stagnation region with the increased dysfunction severity.Due to the complex structure of the mhv, the non-newtonian shear-thinning viscosity blood characteristics become apparent in mhv simulations.The comparative study between newtonian and non-newtonian always shows the difference.The shear-thinning blood viscosity model is the basics to build the blood, also the blood exhibiting viscoelastic properties.More details are needed to establish a complete and more realistic simulation.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Simulation Analysis and Study of Gait Stability Related to Motion Joints

Gait stability in exercise is an inevitable and vexing problem in mechanics, artificial intelligence, sports, and rehabilitation medicine research.With the rapid development and popularization of science and technology, it becomes a reality for researchers to obtain large‐scale human motion data sets in real time with higher efficiency.However, at present, the analysis of gait stability of moving joints is still based on image recognition technology, which is ten times less accurate and inefficient.In this paper, vicon 3d motion capture system, dynamometer, and surface electromyography system were used to obtain the parameters of the lower limbs of the subjects.Using anywhere modeling and simulation system, simulation experiments were carried out, and the reaction force data of lower limb joints under two environments were obtained.The gait characteristics of human gait were analyzed from the angle of internal and external adjustment mechanism.Combining one‐way anova and incremental occupancy rate, the adjustment process of gait stability is described comprehensively.The findings of this study can provide a theoretical basis for the research of lower limb con‐assistive devices and can guide the design and development of bipedal anthropomorphic robots.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Sevoflurane Inhibits lncRNA HOTAIR-Modulated Stability of HK2 mRNA in a m6A-Dependent Manner to Dampen Aerobic Glycolysis and Proliferation in Lung Cancer

Previous studies have shown that sevoflurane has an inhibitory effect on tumor cells.So far, the effect of sevoflurane on hepatocellular carcinoma needs to be confirmed by more studies.Hox transcript antisense intergenic rna (hotair), a long noncoding rna (lnc rna), has been shown to enhance cancer cell proliferation and medication resistance.The inherent importance and biological function of hotair in the course of lung cancer (lc) is, however, poorly unclear.Hotair was shown to be highly elevated in lc cells in this investigation.Impairment of function trials with sevoflurane indicated that it has anticancer effects on lc cell growth, apoptosis, and aerobic glycolysis.In a mechanistic manner, hotair was related to hk2 m rna and promoted expression and constancy.Additional research revealed that hotair coupled with hexokinase 2 (hk2) m rna and favorably controlled its stabilization in a traditional‐component way.By hk2, the lc enhancement role was mediated.In summary, our data show that hotair promotes the synthesis and proliferation of lc glycogen by increasing the transcription of hk2, and hotair is likely to be a potential treatment for lc patients.

Journal: BioMed Research International (2022)
Publication types: Research Article;