syedzayyan/paper_mill_benchmark huggingface dataset:
Value of Artificial Neural Network Ultrasound in Improving Breast Cancer Diagnosis

Ultrasound-guided needle biopsy based on artificial neural network, as a safe, effective, and simple preoperative pathological diagnosis technique, has been widely used in clinical practice.Ultrasound-guided needle biopsy based on artificial neural networks for suspicious breast lesions found in conventional ultrasound examinations is an effective method for preoperative diagnosis.The purpose of this article is to study the value of artificial neural network ultrasound in improving breast cancer diagnosis.This article summarizes the neuron model of pcnn by observing and studying its impulse synchronization phenomenon.Aiming at gray-scale images disturbed by mixed noise (impulse noise and the gaussian noise), a comprehensive filtering algorithm based on the simplified pcnn model is proposed.In this paper, the benign and malignant breast masses were evaluated based on the two-dimensional and three-dimensional ultrasound imaging signs of the mass, and compared with the postoperative pathological results, a logistic regression model was established to analyze the shape, boundary, microcalcification, and posterior echo attenuation of the mass, values for keratinization or burrs, convergent signs, and blood flow classification in the differential diagnosis of benign and malignant.In this paper, a color ultrasound diagnostic device is used, sonobi is used as a contrast medium, and the injection volume is 2.4 ml/dose.During the imaging process, the sound image performance of the lesion is dynamically observed, the original dynamic data are stored throughout the whole process, and the playback analysis is performed after the imaging is completed.Studies have shown that cdus elastography (ue) combined with mri can increase the sensitivity of breast cancer diagnosis, with a diagnostic accuracy rate of 92.4%.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Type 2 Diabetes Mellitus (T2DM) and Carbohydrate Metabolism in Relation to T2DM from Endocrinology, Neurophysiology, Molecular Biology, and Biochemistry Perspectives

Type 2 diabetes mellitus (t2dm) is a severe disease caused by metabolic disorders, particularly carbohydrate metabolism disorders.The disease is a fatal global trouble characterised by high prevalence rates, causing death, blindness, kidney failure, myocardial infarction, amputation of lower limps, and stroke.Biochemical metabolic pathways like glycolysis, gluconeogenesis, glycogenesis, and glycogenolysis are critical pathways that regulate blood glucose levels with the glucokinase (gk) enzyme playing a central role in glucose homeostasis.Any factor that perturbs the aforementioned biochemical pathways is detrimental.Endocrinological, neurophysiological, and molecular biological pathways that are linked to carbohydrate metabolism should be studied, grasped, and manipulated in order to alleviate t2dm global chaos.The challenge, howbeit, is that, since the body is an integration of systems that complement one another, studying one “isolated” system is not very useful.This paper serves to discuss endocrinology, neurophysiology, and molecular biology pathways that are involved in carbohydrate metabolism in relation to t2dm.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
The Relationship between Body Composition and Bone Mineral Density of Female Workers in A Unit of Tai’an

To explore the relationship between body composition and bone mineral density (bmd) of female workers in a university of tai’an.Methods.This study randomly selected 90 female employees in a university of tai’an.The body composition was monitored by body composition analyzer (inbody770), and the lumbar bone mineral density was monitored by dual energy x-ray absorptiometry (bmd model).The data were analyzed by spss 22.0 statistical software.Results.With the increasing of body mass index (bmi), bmd of female lumbar spines 1-4 (l1-4) increased gradually.Spearman correlation analysis showed that bmi, skeletal muscle mass, upper limb muscle mass, trunk muscle mass, lower limb muscle mass, and whole-body phase angle were positively correlated with l1-4bmd.Age was negatively correlated with l1-4bmd.Linear regression analysis showed that age was a negative factor of l1-4bmd, and skeletal muscle mass was a protective factor of abnormal bone mass, especially lower limb muscle mass.Conclusions.Lower limb muscle mass is a protective factor of female bmd.Strengthening physical exercise to improve lower limb muscle mass is conducive to the prevention of female osteoporosis.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
The Higher Expression of CDCA2 Associated with Poor Prognosis in Glioma

Glioma is the most common primary intracranial tumor and is related to poor clinical outcomes.The developments of sensitive markers can be applied to reveal the mechanisms involved in the progression of glioma.This study examined cdca2 expression in glioma samples and its significance in predicting glioma patient outcome.Gepia and geo datasets were used to explore the expression of cdca2 in glioma.Kaplan-meier and multivariate assays were applied to delve into the prognostic values of cdca2 expression in glioma patients using cgga datasets.Our group also determined the associations between cdca2 and clinical characteristics.Coexpression analysis was performed.In this research, we observed that cdca2 expression was distinctly upregulated in glioma specimens compared with nontumor specimens.The prognosis of glioma with high cdca2 expression was distinctly worse compared with that of glioma with low cdca2 expression.Additionally, multivariate cox regression analysis revealed that high cdca2 expression was an independent poor prognostic indicator for glioma patients.High expression of cdca2 was positively associated with advanced clinical progression.Coexpression analysis revealed that cdca2 could be positively related to aspm, ska1, dlgap5, ncapg, and cdca8 and was negatively associated with etnppl, ldhd, mrvi1, cbx7, and cenpj.Overall, our findings revealed that cdca2 might serve as an independent prognosis indicator for glioma.

Journal: Disease Markers (2022)
Publication types: Research Article;
The Clinical Efficacy and Economic Benefits of Recombinant Human Thrombopoietin for the Treatment of Chemotherapy or Chemoradiotherapy-Induced Thrombocytopenia

Even though cytopenia caused by either chemotherapy or radiotherapy is a common complication in cancer patients, chemoradiotherapy remains an essential treatment for the majority of patients.The purpose of this study was to look into the clinical efficacy and cost‐effectiveness of recombinant human thrombopoietin (rh tpo) in treating chemo‐ or chemoradiotherapy‐induced grade ii, iii, and iv thrombocytopenia.From december 2019 to november 2020, 233 lung cancer patients admitted to our hospital with chemotherapy‐ or chemoradiotherapy‐induced thrombocytopenia were enrolled and treated with rh tpo.The study's findings revealed a significant disparity in the use of concurrent chemoradiotherapy in patients with grade ii, iii, and iv thrombocytopenia.All costs, including rh tpo treatment costs, platelet costs, drug costs, and nondrug costs, tended to rise as the severity of thrombocytopenia increased.In the treatment of chemotherapy or radiotherapy‐induced thrombocytopenia, rh tpo has shown good clinical efficacy.In the treatment of grade ii thrombocytopenia, rh tpo has a favorable economic evaluation.As a result, early intervention and thrombocytopenia treatment should be provided, which warrants further clinical investigation.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Surgical Selection of T1 Stage Renal Tumor Resection Based on Imaging MAP Score under Smart Medical Care

Smart medical uses the medical information platform and the current technological means to enable the process of sharing information between medical staff and medical equipment.The combination of current technology and the medical field has become the norm.In the future, more artificial intelligence technologies will be integrated into the medical field to promote the development of medical care.At present, the information on the internet is very large and complex, and general search engines often do not have knowledge in certain professional fields and can only perform shallow keyword searches.Therefore, it is difficult to meet people’s medical diagnosis needs, and smart medical care can solve these needs.Medical imaging refers to the technology or process of obtaining internal tissue images of a certain part of the human body for medical research, including medical imaging systems and medical image processing.Medical image processing refers to the further processing of the obtained images, the purpose of which is either to restore the original image that was not clear enough or to highlight some characteristic information in the image.The purpose of this paper is to study the research on the selection of t1 stage renal tumor resection based on the imaging map score under smart medical care.It is hoped that through smart medicine and medical imaging technology, it can help renal tumor resection, reduce the sequelae of renal tumor resection, and promote the development of medical services.This paper proposes applying natural language processing technology to the medical field, creating an intelligent diagnosis assistance system, and using the existing medical record data to realize the corresponding medical assistance functions.It studies the class imbalance problem prevalent in medical datasets and provides better solutions through ensemble learning techniques to improve classifier performance when the number of positive and negative samples is unbalanced.The experimental results in this paper show that the creatinine of patients undergoing renal tumor resection combined with smart medicine and imaging technology is stable at 75 mol/l, while the creatinine is stable at 71 mol/l in other methods.It shows that the postoperative effect of smart medical treatment and imaging technology is better.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem Cells

This study aimed to investigate the molecular mechanisms of micro rna-146a (mi r-146a) on gingival mesenchymal stem cells (mscs).Gingival mscs were isolated from the gingiva tissues of patients with periodontal disease to reveal the function of mi r-146a in regulating osteoblast differentiation.Mi r-146a inhibits osteoblast differentiation by inhibiting phosphorylated cyclic-amp response binding (creb) protein translocation into the nucleus and ultimately attenuating runt-related transcription factor 2 (runx2) expression.Furthermore, silencing mi r-146a promotes the proliferation of gingival mscs.Of note, targeted inhibition of mi r-146a also inhibited lps-induced inflammatory response and promoted the proliferation of gingival mscs via creb/runx2 axis.Mi r-146a is a key negative regulator of gingival mscs proliferation and osteogenic differentiation, and targeting to reduce the mi r-146a expression is essential for bone formation signaling.Therefore, we propose that mi r-146a is a useful therapeutic target for the development of bone anabolic strategies.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Study on the Mechanism of Action of STAT3 in the Drug Resistance of Gastric Cancer Cells

Gastric cancer is the most common digestive tract malignancy in china and has a poor prognosis, with a 5‐year overall survival rate of only 35.1%.Because its early symptoms are not obvious and early diagnosis is complicated, there is an urgent need to find biological targets for diagnosis and treatment.This research detected the expression of stat3 in gastric cancer tissues and adjacent tissues by western blot and immunohistochemical experiments and conducted corresponding basic experiments to explore the role of stat3 in inhibiting the proliferation of cisplatin‐resistant gastric cancer cells and promoting their apoptosis, including the construction of cisplatin‐resistant gastric cancer cell line, the knock‐out stat3 in drug‐resistant gastric cancer cells by crispr‐cas9, and the comparison of the proliferation and apoptosis of drug‐resistant cells and drug‐resistant cells stat3(‐).The mechanism provides a possible intervention target for clinically improving the prognosis of patients with cisplatin‐resistant gastric cancer.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Study on the Effect of Hope Theory Combined with Psychological Intervention on the Improvement of Prognosis

In order to evaluate the effect of the hope theory combined with psychological intervention on patients with intracranial aneurysms after surgical treatment, a total of 98 patients with intracranial aneurysm surgery admitted to our hospital from march 2019 to january 2021 were analyzed.According to the random number table method, all patients are divided into two groups: the traditional group and the experimental group.After intracranial aneurysm surgery, the patients of the traditional group and of the joint group are treated with conventional nursing and hope theory combined with psychological intervention nursing mode, respectively.The results demonstrate that the hope theory combined with psychological intervention can improve the level of postoperative patients with intracranial aneurysm life hope, self‐efficacy, and postoperative quality of life.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Study on the Cytotoxic Microstructure of Titanium Dioxide Nanoparticles by X-Ray Phase-Contrast CT Imaging

To address the problem of microstructural analysis of titania nanoparticles with high cytotoxicity, the authors propose x‐ray phase‐comparative ct imaging studies.In this method, the he‐stained section samples were compared with the x‐ray phase‐contrast ct imaging microscopic images, and 3d texture analysis was used to observe the changes in the preparation of hepatocyte microstructures in the two groups.The results show that x‐ray phase‐contrast ct imaging microscopic images and their larger image size are closely related to he staining images, and x‐ray phase‐contrast ct microscopic images can observe important data of hepatocytes from multiple angles.The ship skeleton extraction method based on the endpoint limit also has advantages over traditional algorithms in extraction accuracy and can provide more 3d feature files, confirming the growth and transformation of normal hepatocytes into hepatocyte cytotoxic microstructures.The distribution effect of using the ensemble process is better than the simple 2d feature set and 3d feature set, and the overall accuracy is improved; the result distribution of the tree determination and random forest methods is also better than that of the support vector machine method.The experimental results show that the x‐ray phase‐contrast ct images can highlight the 2d and 3d imaging features of the hepatotoxic microstructure of ti o 2 nanoparticles and provide data for quantitative analysis.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Study on the Changes and Significance of Immune State and Cycokines in Children with Adenovirus Pneumonia

To observe the difference between peripheral blood t lymphocytes subsets and cycokines in children with severe adenovirus pneumonia and nonsevere adenovirus pneumonia, and to investigate their clinical value in the prognosis of severe pneumonia.Methods.215 children with adenovirus pneumonia and 30 healthy volunteers (which was set as the control group) in our hospital from january 2017 to may 2019 were enrolled in the study.There were 47 children with severe pneumonia in the severe group and 168 nonsevere pneumonia children in the nonsevere group.The flow cytometry and elisa methods were used to detect the serum levels of cd3+, cd4+, cd8+ t cells and interleukin-2 (il-2), il-4, il-6, il-10, tumor necrosis factor-α (tnf-α), interferon-γ (ifn-γ).Results.(1) the levels of cd3 (%) t cells, cd4 (%) t cells, and cd4/cd8 ratio values of children with adenovirus pneumonia were lower than these of normal children ( p &lt; 0.05 ).And the levels of cd3 (%) t cells, cd4 (%) t cells, and cd4/cd8 ratio values of children in the severe group were lower than these of children in the nonsevere group ( p &lt; 0.05 ).(2) the levels of il-2, il-6, il-10, tnf-α, and ifn-γ values of children with adenovirus pneumonia were lower than these of normal children ( p &lt; 0.05 ).And the levels of il-2, il-6, il-10, tnf-α, and ifn-γ of children in the severe group were higher than these of children in the nonsevere group ( p &lt; 0.05 ).(3) among the 47 children with severe adenoviral pneumonia, 39 received systematic treatment in our hospital.According to the treatment effect, 39 children were divided into the effective group (n = 25) and the ineffective group (n = 14).(4) the cd3 (%), cd4 (%), and cd4/cd8 ratios of the children in the effective group were higher than those in the ineffective group ( p &lt; 0.05 ).(5) the levels of il-2, il-6, il-10, tnf-α, and ifn-γ in the effective group were lower than those in the ineffective group ( p &lt; 0.05 ).Conclusion.The immunophenotype of peripheral blood t lymphocytes and cycokines could be helpful to judge the severity of adenovirus pneumonia, which could be used as the objective indexes to evaluate the prognosis of children with severe adenovirus pneumonia.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Study on BCVA, CMT, CME, Curative Effect, and Prognostic Value of DR Sufferers Based on Surgical Therapy Combined with VEGF Therapy at Different Times

In order to explore the efficacy and prognostic value of best corrected visual acuity (bcva), central macular retinal thickness (cmt), and cystoid macular edema (cme) in diabetic retinopathy (dr) sufferers based on surgical therapy combined with vascular endothelial growth factor (vegf) therapy at different times, a total of 170 cases of dr sufferers who visited our hospital from march 2019 to march 2021 are analyzed.All patients are randomly divided into control group and study group, with 85 cases and 85 eyes in each group.In addition, the contrast set received 2 therapies for 1.5 months/time, and the study set received 3 therapies for 1 month/time.The experimental results show that the bcva of the two sets is notoriously enhanced.Besides, cmt and cme in the study set decrease more than those in the contrast set, and the blood vessel density of retinal capillaries in the contrast set and the examination set is notoriously enhanced.For dr sufferers, 1 month/time of anti‐vegf therapy can effectively enhance the sufferers’ visual acuity, cmt and cme.It is suggested that the clinical application of 1 month/time of anti‐vegf to dr sufferers can enhance the clinical therapeutic effect of sufferers and reduce the prognosis and recurrence.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Clinical Study;
Segmentation of Oral Leukoplakia (OL) and Proliferative Verrucous Leukoplakia (PVL) Using Artificial Intelligence Techniques

Pvl (proliferative verrucous leukoplakia) has distinct clinical characteristics.They have a proclivity for multifocality, a high recurrence rate after treatment, and malignant transformation, and they can progress to verrucous or squamous cell carcinoma.Ai can aid in the diagnosis and prognosis of cancers and other diseases.Computational algorithms can spot tissue changes that a pathologist might overlook.This method is only used in a few studies to diagnose lb and pvl.To see if their cellular nuclei differed and if this cellular compartment could classify them, researchers used a computational system and a polynomial classifier to compare ols and pvls.161 ol and 3 pvl specimens in the lab were grown, photographed, and used for training and computation.Exam orders revealed patients’ sociodemographics and clinical pathologies.The nucleus was segmented using mask r‐cnn, and lb and pvl were classified using a polynomial classifier based on nucleus area, perimeter, eccentricity, orientation, solidity, entropies, and moran index (a measure of disorderliness).The majority of ol patients were male smokers; most pvl patients were female, with a third having malignant transformation.The neural network correctly identified cell nuclei 92.95% of the time.Except for solidity, 11 of the 13 nuclear characteristics compared between the pvl and the lb showed significant differences.The 97.6% under the curve of the polynomial classifier was used to classify the two lesions.These results demonstrate that computational methods can aid in diagnosing these two lesions.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Research Progress of PI3K/PTEN/AKT Signaling Pathway Associated with Renal Cell Carcinoma

Renal cell carcinoma is a common renal malignancy of the urinary system and the most malignant type of kidney cancer.Phosphatidylinositol 3-kinase (pi3k) is an intracellular phosphatidylinositol kinase associated with oncogene products such as v-src and with serine/threonine kinase activity, and its increased activity correlates with the development of several cancers.Protein kinase b (akt) is a cyclic guanosine phosphate-dependent protein kinase that plays an important role in cell survival and apoptosis.Phosphatase and tensin homolog (pten), a newly discovered oncogene in recent years, participates in tumorigenesis and development by competing with tyrosine kinases for common substrates.The product encoded by pten was found to negatively regulate the pi3k/akt signaling pathway, thereby inhibiting cell proliferation and promoting apoptosis.The pi3k/pten/akt signaling pathway has also been identified in several studies as being involved in the development of several malignancies, including renal cell carcinoma.Radiotherapy is currently one of the most effective means of treatment for renal cell carcinoma, whereas it is predisposed to significant tolerance during the course of radiotherapy, thereby leading to treatment failure.Therefore, new treatment options may potentiate the efficiency of renal cell carcinoma treatment.With the development of tumor molecular biology, targeted biological therapy for malignant tumors has gradually become a research hotspot.Given the above research background, this study reviews the application of the pi3k/pten/akt signaling pathway in renal cell carcinoma, aiming to provide more references for the treatment of clinical renal cell carcinoma.

Journal: Disease Markers (2022)
Publication types: Research Article;