syedzayyan/paper_mill_benchmark huggingface dataset:
Good prognosis for survival to hospital discharge in a group of horses with uterine prolapse treated at a veterinary medical teaching hospital.

To describe uterine prolapse, predispositions, and outcomes in mares treated between 1988 and 2019.Animals 24 mares with uterine prolapse.Procedures clinical records were retrospectively reviewed, and follow-up information was gathered.The mann-whitney u test and fisher exact test were used to analyze results for history and outcome variables for potential association with mare survival to hospital discharge.The χ2 test was used to compare breed distribution.Results age was known in 23 mares (median, 11.1 years).For 15 mares with exact known parity, the median parity was 3 births (range, 1 to 13 births).For 22 mares, the maiden status was known (7 [32%] maiden; 15 [68%] multiparous).Breed distribution differed significantly between mares with uterine prolapse and all mares treated at the veterinary medical teaching hospital.Arabians were overrepresented in the uterine prolapse group (7/24 [29%]), compared with all mares treated (4,174/44,474 [9%]).Uterine prolapse occurred within 2 hours after parturition for 10 of 11 mares with known foaling times, after dystocia for 7 mares, and after abortion for 4 mares.Seventeen of 23 (74%) mares survived to hospital discharge.Acute hemorrhage was the most frequent cause of death.There were no correlations between mare survival to hospital discharge and mare parity or age, foal sex, retained fetal membranes, sepsis, or maiden status.Colts were overrepresented in foals with a known sex (12/17).Clinical relevance results indicated a breed predisposition to uterine prolapse, with arabian mares overrepresented among affected mares.No characteristics correlated with mare survival to hospital discharge.

Journal: Journal of the American Veterinary Medical Association (2022)
Publication types: Journal Article
Application of the Kaiser score by MRI in patients with breast lesions by ultrasound and mammography.

This study aimed to verify whether the use of the kaiser score can improve the diagnostic performance in breast magnetic resonance imaging (mri) for suspicious lesions and avoid further invasive diagnostic approaches.Methods this retrospective study enrolled 97 patients who underwent breast mri before undergoing breast biopsy or surgery.Evaluations were conducted on all mri images individually by 2 radiologists using the kaiser score.Neither radiologist had the knowledge of the final histopathological diagnosis.The ability of the kaiser score in diagnosis was established via a receiver performing characteristic (roc) analysis, which was measured by the area under the roc curve (auc).Youden index was used to define the optimal cutoff value.Kaiser score categories were dichotomized into positive (cutoff score > 4) and negative scores (cutoff score ≤ 4).Cohen's kappa coefficient was used to analyze the inter-rater agreement.Results histopathology revealed 56 malignant and 41 benign lesions.The auc for all lesions evaluated by the kaiser score was 0.992 (95% ci: 0.981-1.0) and 0.958 (95% ci: 0.920-0.996) for 2 radiologists, respectively.Inter-rater agreement of the dichotomized kaiser score was excellent (κ=0.894, p < .001).A total of 20 lesions (33.8%) previously categorized as bi-rads 4 were reduced to bi-rads 2/3 (19 benign lesions and 1 malignant lesion).Conclusion the kaiser score is a valuable auxiliary diagnostic tool for improving the diagnostic ability of radiologists, whose experiences in breast mri are diverse.In some cases, the application of the kaiser score could possibly avoid unnecessary breast biopsies.

Journal: Diagnostic and interventional radiology (Ankara, Turkey) (2022)
Publication types: Journal Article
Diabetes Education and Support Tele-Visit Needs Differ in Duration, Content, and Satisfaction in Older Versus Younger Adults.

Diabetes education and support are critical components of diabetes care.During the covid-19 pandemic, when telemedicine took the place of in-person visits, remote certified diabetes care and education specialist (cdces) services were offered to address diabetes education and support.Specific needs for older adults, including the time required to provide education and support remotely, have not been previously reported.Methods adults with diabetes (primarily insulin-requiring) were referred to remote cdcess.Utilization was individualized based on patient needs and preferences.Topics discussed, patient satisfaction, and time spent in each tele-visit were evaluated by diabetes type, age, sex, insurance type, glycosylated hemoglobin (hb a1c), pump, and continuous glucose monitor (cgm) usage.t-tests, one-way analysis of variance, and pearson correlations were employed as appropriate.Results adults (n= 982; mean age 48.4 years, 41.0% age ≥55 years) with type 1 diabetes (n= 846) and type 2 diabetes mellitus (n= 136, 86.0% insulin-treated), 50.8% female; 19.0% medicaid, 29.1% medicare, 48.9% private insurance; mean hb a1c 8.4% (standard deviation 1.9); and 46.6% pump and 64.5% cgm users had 2203 tele-visits with remote cdcess over 5 months.Of those referred, 272 (21.7%) could not be reached or did not receive education/support.Older age (≥55 years), compared with 36-54 year olds and 18-35 year olds, respectively, was associated with more tele-visits (mean 2.6 vs.2.2 and 1.8) and more time/tele-visits (mean 20.4 min vs.16.5 min and 14.8 min;p 50 min for most older participants.This suggests that new reimbursement models are needed.Education/support needs of insulin-treated older adults should be a focus of future studies.

Journal: Telemedicine reports (2022)
Publication types: Journal Article
The Effect of the Molecular Dipole and Quadrupole moments on Ion-Molecule Reaction Rates near 0 K.

We review the results of our recent experimental and theoretical studies of gas-phase ion-molecule reactions involving the he+ ion at low collision energies (ecoll), in the k b⋅(0 - 40) k range.To avoid heating of the ions by stray electric fields, the reactions are studied within the orbit of a rydberg electron.We reach collision energies down to ~0 k by employing a merged-beam setup.In the case of a molecule with a dipole moment (e.g., ammonia), we observe a strong enhancement of the measured reaction yield with decreasing ecoll.This enhancement is attributed to rotational states which experience linear negative stark shifts in the electric field of the ion.When the molecule has no dipole moment but a negative quadrupole moment (e.g., n2), we observe a suppression of the total reaction yield at the lowest collision energy.Our results are interpreted with the aid of an adiabatic-channel model.

Journal: Chimia (2022)
Publication types: Journal Article
Experiences of caregivers by care recipient's health condition: A study of caregivers for Alzheimer's disease and related dementias versus other chronic conditions.

This study described experiences of caregivers of persons with alzheimer's disease and other dementias (adrd) and caregivers of persons with other chronic conditions on self-reported health, type of assistance they provide, perceptions of how caregiving interferes with their lives, and perceived level of support.A secondary analysis was conducted of the 2013 porter novelli summer styles survey data.Of the 4033 respondents, 650 adults self-identified as caregivers with 11.6% caring for people with adrd.Over half of all caregivers reported that caregiving interfered with their lives to some extent.The greater the perceived support caregivers reported, the less they thought that caregiving interfered with their lives (p < .001).No significant differences were found between adrd and non-adrd caregivers regarding general health, types of assistance they provided, and perceived level of support.These findings have the potential to inform future research and practice in the development of supportive services for caregivers.

Journal: Geriatric nursing (New York, N.Y.) (2019)
Publication types: Journal Article;Research Support, U.S. Gov't, P.H.S.
Loss of miR-198 and -206 during primary tumor progression enables metastatic dissemination in human osteosarcoma.

The metastatic dissemination is a complex multistep process by which tumor cells from a primary site enter into the systemic circulation to finally spread at distant sites.Even if this mechanism is rare at the tumor level, it remains the major cause of osteosarcoma-patients' relapse and mortality.Micro rnas (mi rnas) have recently been described as novel epigenetics' genes' expression regulators actively implicated in cancer progression and dissemination.The understanding of their implication in the metastatic spreading could help clinicians to improve the outcome of osteosarcoma.We established the mi rna's expression-profile between primary bone-tumors (pts), circulating tumor cells (ctcs) and lung metastatic (meta) samples fromin vivomice xenograft models.Our results show that the expression level of the mi r-198 and -206 was decreased in meta samples, in which the expression of the metastasis-related receptor c-met was up-regulated.Those expression variations were validated in osteosarcoma patient biopsies from matching primary tumors and lung metastasis.We validatedin vitrothe endogenous mi rnas inhibitory effects on both migration and invasion, as well as we confirmed by luciferase assays that the c-met receptor is one of theirbona-fidetargets.The anti-metastatic effect of these mi rnas was also validatedin vivo, as their direct injections into the tumors reduce the number of lung-metastases and prolongs the overall survival of the treated animals.All together, our results suggest the absence of the mi r-198 and -206 as powerful predictive biomarkers of the tumor cell dissemination and the rationale of their potential therapeutic use in the treatment of osteosarcoma.

Journal: Oncotarget (2018)
Publication types: Journal Article
The Pathogenic Role of Smooth Muscle Cell-Derived Wnt5a in a Murine Model of Lung Fibrosis.

Idiopathic pulmonary fibrosis (ipf) is a disease characterized by extensive fibrosis of the lung tissue.Wnt5a expression was observed to be upregulated in ipf and suggested to be involved in the progression of the disease.Interestingly, smooth muscle cells (smc) are a major source of wnt5a in ipf patients.However, no study has been conducted until now to investigate the precise role of smooth muscle-derived wnt5a in ipf.Here, we used the bleomycin-induced lung fibrosis model in a conditional gene-deficient mouse, where the wnt5a gene was excised from smc.We show here that the excision of the wnt5a gene in smc led to significantly improved health conditions with minimized weight loss and improved lung function.This improvement was based on a significantly lower deposition of collagen in the lung with a reduced number of fibrotic foci in lung parenchyma.Furthermore, the bleomycin-induced cellular infiltration into the airways was not altered in the gene-deficient mice compared with wild-type mice.Thus, we demonstrate that the wnt5a expression of smc of the airways leads to aggravated fibrosis of the lung with poor clinical conditions.This aggravation was not an influence in the bleomycin-induced inflammatory processes but on the development of fibrotic foci in lung parenchyma and the deposition of collagen.

Journal: Pharmaceuticals (Basel, Switzerland) (2021)
Publication types: Journal Article
Characteristics and factors that influence heavy metal leaching from spent catalysts.

With the extensive use of nonferrous metals and metal catalysts, solid wastes containing heavy metals release metal ions into soil and surface water through erosion and leaching.This is one of the major threats to the global environment and human health.Studying the characteristics and impact factors of heavy metal leaching from solid waste is a critical part of managing spent catalysts and environmental risk.In this work, the characteristics of and factors that influence leaching and seepage release from typical spent catalysts and lead-zinc smelting slag were studied.The results indicated that metal ions leached more easily in an acidic environment (p h 4.5) and an environment with dom than in a neutral environment (p h 7.0).Metal ion leaching was favored by a liquid-to-solid ratio of 20:1.The concentrations of metal ions released from the spent catalysts in sequential leaching experiments were higher than those in column leaching experiments.Leaching of metal ions in the presence of different leaching agents and from different spent catalysts can be described by different controlling models of the shrinking core model, but changes in the liquid-to-solid ratio showed no obvious correlation with changes in the metal release mechanism.These results provide important information for spent catalyst management and risk prevention and control.

Journal: Environmental science and pollution research international (2022)
Publication types: Journal Article
Neuropeptide Y and its receptors are expressed in chicken skeletal muscle and regulate mitochondrial function.

Neuropeptide y (npy) is a highly conserved 36-amino acid neurotransmitter, which is primarily expressed in the mammalian arcuate nucleus of the hypothalamus.It is a potent orexigenic neuropeptide, stimulating appetite and inducing feed intake in a variety of species.Recent research has shown that npy and its receptors can be expressed by peripheral tissues, but their role is not yet well defined.Specifically, this information is particularly sparse in avian species.Therefore, the aim of this study was to determine the expression of npy and its receptors, and determine their regulation by environmental and nutritional stressors, in the skeletal muscle of avian species using in vivo and in vitro approaches.Here, we show that npy and its receptors are expressed in chicken breast and leg muscle as well as in quail myoblast (qm7) cell line.Intraperitoneal injection of recombinant npy increased feed intake in 9-d old chicks and upregulated the expression of npy and npy receptors in breast and leg muscle, suggesting autocrine and/or paracrine roles for npy.Additionally, npy is able to modulate the mitochondrial network.In breast muscle, a low dose of npy upregulated (p < 0.05) the expression of genes involved in atp production (uncoupling protein, ucp; nuclear factor erythroid 2 like 2, nfe2l2) and dynamics (mitofusin 1, mfn1), while a high dose decreased (p < 0.05) markers of mitochondrial dynamics (mitofusin 2, mfn2; opa1 mitochondrial dynamin like gtpase, opa1) and increased (p < 0.05) genes involved in mitochondrial biogenesis (d-loop, peroxisome proliferator activated receptor gamma, pparg).In leg muscle, npy decreased (p < 0.05) markers of mitochondrial biogenesis and atp synthesis (d-loop; peroxisome proliferator activated receptor alpha, pcg1a; peroxisome proliferator-activated receptor gamma, coactivator 1 beta, ppargc1b; pparg; nfe2l2).In qm7 cells, genes associated with mitochondrial biogenesis, dynamics, and atp synthesis were all upregulated (p < 0.05), even though basal respiration and atp production were decreased (p < 0.05) with npy treatment as measured by xf flux analysis.Together, these data show that the npy system is expressed in avian skeletal muscle and plays a role in mitochondrial function.

Journal: General and comparative endocrinology (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Histone methyltransferase KMT2D mediated lipid metabolism via peroxisome proliferator-activated receptor gamma in prostate cancer.

Prostate cancer (pca) is the most common type of cancer in men.Destruction of or blocking lipid metabolism impairs the growth, proliferation, and survival of tumor cells.Recent studies on hepatic steatosis suggest that kinase tethers histone-lysine n-methyltransferase 2d (kmt2d) to peroxisome proliferator-activated receptor gamma (pparγ), transactivating its target genes.Here, to determine a therapeutic approach that may interfere with pca lipid metabolism, the interaction mechanism of kmt2d and pparγ was verified in pca.Methods molecular techniques and bioinformatics analysis were used to explore the relationship between kmt2d and lipid metabolism pathways in pca.Moreover, the changes of lipid droplets were detected by oil red o staining and bodipy staining.Molecular techniques were used to investigate the effect of kmt2d on pparγ signaling in pca cells.Co-immunoprecipitation (co-ip) and dna pull-down verified the mechanism of interaction between kmt2d and pparγ.Results kmt2d knockdown reduced the lipid droplet content in pc-3 and du-145 cells and downregulated the expression of lipid metabolic genes.Low-dose rosiglitazone (rosi) effectively activated the pparγ pathway to promote lipid droplet synthesis and cell proliferation and migration.However, rosi could not function effectively after kmt2d knockdown.Both co-ip and dna pull-down analyses showed that kmt2d and pparγ could be tethered to regulate the expression of pparγ target genes.Conclusions in pca, kmt2d interacted with pparγ, which directly participated in the regulation of lipid metabolism-related genes and affected lipid synthesis.Therefore, inhibiting the interaction between kmt2d and pparγ is a potential therapeutic strategy.

Journal: Translational cancer research (2022)
Publication types: Journal Article
Behavioral Changes After the COVID-19 Lockdown in Italy.

This study aims at identifying the tools necessary for covid-19 health emergency management, with particular reference to the period following the first lockdown, a crucial phase in which it was important to favor the maintenance of protective behaviors.It also aims at identifying the messages and sources that were most effective in managing communication correctly in such a crucial phase that is likely characterized by a fall in perceived health risk (due to the flattening of the epidemic curve) and a simultaneous rise in perceived economic and social risks (due to the enduring calamity).Knowing what source will be most effective to convey a specific message is fundamental in enabling individuals to focus on and comply with the rules.At the same time, it is necessary to understand how the message should be presented, and the relationships between messages, sources and targets.To meet these goals, data were collected through a self-administered online questionnaire submitted to a sample of undergraduate students from a university in lombardy-the region most affected by the pandemic in the first wave- (study 1), and to a national sample composed of italian citizens (study 2).Through our first manipulation which explored the effectiveness of social norms in relation to different sources, we found that, in the national sample, the injunctive norm conveyed by the government was the most effective in promoting behavioral intentions.By contrast, among the students, results showed that for the critical group with a lower risk perception (less inclined to adopt prevention behavior) descriptive norms, which implicitly convey the risk perception of peers, were as effective as the government injunctive norm.Our second manipulation, identical in study 1 and 2, compared four types of communication (emotional, exponential growth, both of them, or neutral).The neutral condition was the most memorable, but no condition was more effective than the others.Across all message types there was a high intention to adopt protective behaviors.The results indicate possible applicative implications of the adopted communicative tools.

Journal: Frontiers in psychology (2021)
Publication types: Journal Article
Aging-associated immune system changes in multiple myeloma: The dark side of the moon.

Multiple myeloma (mm) is a disease of the elderly.Changes that occur in the immune system with aging, also known as immunosenescence, have been associated with decreased tumor immunosurveillance and are thought to contribute to the development of mm and other cancers in the elderly.Once mm establishes itself in the bone marrow, immunosenescence related changes have been observed in the immune tumor microenvironment (i tme) and are driven by the malignant cells.The efficacy of novel immunotherapies used to treat mm has been blunted by detrimental i tme changes that occur at later disease stages and are, to some extent, driven by prior therapies.In this review, we discuss general changes that occur in the immune system with aging as well as our current knowledge of immunosenescence in mm.We discuss the differences and overlap between t cell senescence and exhaustion as well as potential methods to prevent or reverse immunosenescence.We focus predominantly on t cell immunosenescence which has been better evaluated in this disease and is more pertinent to novel mm immunotherapies.Our lack of understanding of the drivers of immunosenescence at each stage of the disease, from precursor stages to heavily pretreated mm, represents a major barrier to improving the efficacy of novel and existing therapies.

Journal: Cancer treatment and research communications (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Review
Genetic and molecular understanding of host rice resistance and Nilaparvata lugens adaptation.

The variability of brown planthopper (bph) populations and diversity of the host rice germplasm provide an ideal model for exploring the genetic and molecular basis of insect-plant interactions.During the long-term evolutionary arms race, complicated feeding and defense strategies have developed in bph and rice.Nine major bph resistance genes have been cloned and the exploration of bph resistance genes medicated mechanism against bph shed a light on the molecular basis of the rice-bph interaction.This short review provides an update on our current understanding of the genetic and molecular mechanism for rice resistance and bph adaptation.Understanding the interactions between bph and rice will provide novel insights for sustainable control of this pest.

Journal: Current opinion in insect science (2021)
Publication types: Journal Article;Review
An EEG channel selection method for motor imagery based brain-computer interface and neurofeedback using Granger causality.

Motor imagery (mi) brain-computer interface (bci) and neurofeedback (nf) with electroencephalogram (eeg) signals are commonly used for motor function improvement in healthy subjects and to restore neurological functions in stroke patients.Generally, in order to decrease noisy and redundant information in unrelated eeg channels, channel selection methods are used which provide feasible bci and nf implementations with better performances.Our assumption is that there are causal interactions between the channels of eeg signal in mi tasks that are repeated in different trials of a bci and nf experiment.Therefore, a novel method for eeg channel selection is proposed which is based on granger causality (gc) analysis.Additionally, the machine-learning approach is used to cluster independent component analysis (ica) components of the eeg signal into artifact and normal eeg clusters.After channel selection, using the common spatial pattern (csp) and regularized csp (rcsp), features are extracted and with the k-nearest neighbor (k-nn), support vector machine (svm) and linear discriminant analysis (lda) classifiers, mi tasks are classified into left and right hand mi.The goal of this study is to achieve a method resulting in lower eeg channels with higher classification performance in mi-based bci and nf by causal constraint.The proposed method based on gc, with only eight selected channels, results in 93.03% accuracy, 92.93% sensitivity, and 93.12% specificity, with rcsp feature extractor and best classifier for each subject, after being applied on physionet mi dataset, which is increased by 3.95%, 3.73%, and 4.13%, in comparison with correlation-based channel selection method.

Journal: Neural networks : the official journal of the International Neural Network Society (2021)
Publication types: Journal Article