syedzayyan/paper_mill_benchmark huggingface dataset:
lncRNA MSC-AS1/miRNA-429 Axis Mediates Growth and Metastasis of Nasopharyngeal Carcinoma via JAK1/STAT3 Signaling Pathway

We attempted to clarify the effect of lnc rna msc-as1 on carcinogenic and development of nasopharyngeal carcinoma (npc) and the related mechanisms.Methods.The levels of msc-as1 and mi r-429 were estimated in npc tissues and cells using q rt-pcr.Correlation analysis, dual-luciferase report, and rna pull down assay assessed the action association of msc-as1 and mi r-429.Mtt, colony formation, cell wound scratch, and transwell assays were used to assess the proliferation, invasion, and migration of c666-1 cells.Metastasis-related protein expressions and activation of the jak1/stat3 pathway were confirmed by western blot and immunohistochemistry.Results.The expression of msc-as1 presented significant upregulation, and mi r-429 expression was markedly downregulated in npc tissues and cells.The level of msc-as1 had negative relation to the mi r-429 level.Knockdown of msc-as1 suppressed the proliferation, invasion, and migration of c666-1 cells.On the contrary, overexpressing of msc-as1 exerts the opposite effects on c666-1 cell growth and migration.Mi r-429 was determined as functional downstream of msc-as1.The suppressive function of msc-as1 knockdown was predominately abolished by the mi r-429 inhibitor.Mi r-429 was an antitumor gene inhibiting npc growth and metastasis through jak1/stat3 pathway.In c666-1 cells, the elevated cell growth and migration induced by the mi r-429 inhibitor were significantly reversed by si-jak1 transfection.Conclusions.High expression of msc-as1 exerted a carcinogenic effect on npc cell growth and metastasis by inhibiting mi r-429 and activating the jak1/stat3 pathway.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
LINC01426 Triggers Growth and Metastasis of Lung Adenocarcinoma as a Prognostic Indicator

The vital regulation of abnormally expressed lnc rnas in human cancers has been identified.This study is aimed at illustrating the role of linc01426 in influencing malignant behaviors of lung adenocarcinoma (luad) and the possible mechanism.Differential expressions of linc01426 in a downloaded profile containing luad and normal tissues were analyzed using gene expression profiling interactive analysis (gepia) database and were reconfirmed in clinical samples collected in our hospital.In addition, linc01426 level in lung carcinoma cell lines was detected by quantitative real‐time polymerase chain reaction (q rt‐pcr) as well.The relationship between linc01426 expression and the age, tumor node metastasis (tnm) staging, lymphatic metastasis, tumor differentiation, and overall survival of luad was analyzed.After intervening linc01426 level in h1299 and pc9 cells, proliferative and metastatic changes were assessed by functional experiments.Linc01426 was upregulated in luad tissues and cell lines.Its level was closely linked to tnm staging, lymphatic metastasis, tumor differentiation, and overall survival of luad.Knockdown of linc01426 suppressed proliferative and metastatic abilities in h1299 and pc9 cells.Linc01246 is upregulated in luad samples and predicts a poor prognosis.It drives malignant process of luad via stimulating proliferative and metastatic abilities.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Ligament Repair Method for Sports Dancers Based on Health Monitoring

In sports dance training, the injury rate of athletes’ ligaments is higher than that of ordinary ones.Careful study of ligament repair methods can better prolong the sports life of sports dance athletes.The purpose of this paper is to investigate how to analyze ligament repair in sports dancers based on health monitoring.This paper proposes a deep learning algorithm based on health monitoring and a neural network algorithm, both of which have the function of prediction.The experimental results of this paper show that the common injuries in sports dance include ankle ligament injury, medial and lateral knee ligament strain, lumbar muscle strain, toe joint strain, shoulder deltoid strain and other injuries.Among them, the number of ankle ligament injuries is the largest, with 36 people, accounting for 30%.The number of people with medial and lateral ligament strains in the knee joint ranks second with 32 people, accounting for 26%.The total proportion of two kinds of ligament strains is 56%, accounting for more than half.It can be seen that ligament strains are the most common in sports dance injuries, so it is of great research significance to repair the ligaments of sports dancers based on health monitoring.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Left Heart Failure Caused by Capacity Overload in Peritoneal Dialysis Patients

This study sets out to investigate the incidence of acute left ventricular failure in peritoneal dialysis patients with different volume loads and to analyze the related risk factors for lvf in these patients.Methods .This study involved patients who received peritoneal dialysis in our hospital between september 2018 and january 2021.The demographic data and biochemical indicators of the patients were collected.The bioimpedance analysis method was used to determine the volume overload [overhydration (oh)] level of patients, and cardiac color doppler ultrasound was used to detect changes in their cardiac structure.According to the lvf diagnostic criteria of symptoms and laboratory tests, the patients were divided into the lvf and non‐lvf groups and then divided according to their oh level into the normal volume (oh ≤1.1 l) and volume overload (oh &gt;1.1 l) groups.The incidence of lvf in was analyzed in patients with different volume loads, and logistic regression was used to identify the risk factors for lvf.Results .Among the 226 peritoneal dialysis patients enrolled in this study, 125 patients (55.3%) had lvf.The normal volume group ( n = 68, 30.1%) included 22 patients (32.4%) with lvf, and the volume overload group ( n = 158, 69.9%) included 84 patients (53.2%) with lvf.In the volume overload group, 74 patients (46.8%) had subclinical volume overload, including 35 patients (47.3%) with lvf, and 84 patients (53.2%) had clinical volume overload, including 65 patients (77.4%) lvf.Multivariate logistic regression analysis revealed a high oh level (or = 1.862, 95% ci: 1.353–2.668, p &lt; 0.001) and low hemoglobin level (or = 0.845, 95% ci: 0.721–0.980, p = 0.008) to be independent risk factors for lvf.Conclusions .Lvf has a high incidence in peritoneal dialysis patients, especially those with volume overload.A high oh level and low hemoglobin level are independent risk factors for lvf.

Journal: BioMed Research International (2022)
Publication types: Research Article;
LCZ696 Ameliorates Isoproterenol-Induced Acute Heart Failure in Rats by Activating the Nrf2 Signaling Pathway

Lcz696 (sacubitril/valsartan) is an angiotensin ii (ang ii) type 1 receptor-neprilysin inhibitor, with effects of immunosuppression, anti-inflammation, antiapoptosis, and antioxidation.The present study was aimed at determining whether lcz696 has a protective effect against isoproterenol-induced acute heart failure (ahf) in rats.Methods.Sd rats were randomly divided into four groups: control group, hf group, lcz696 group, and enalapril group.The cardiac function of rats was evaluated using echocardiographic parameters, heart weight (hw), serum levels of cardiac troponin i (c tn i), and lactate dehydrogenase (ldh).He is staining, which was used to determine the pathological damage of rat myocardial tissue.Also, we measured oxidative stress markers including reactive oxygen species (ros), malondialdehyde (mda), superoxide dismutase (sod), and catalase (cat).Finally, the expression of nrf2 signaling pathway-related proteins was determined using western blot.Results.Compared with the hf group, lcz696 could significantly improve cardiac function and myocardial injury in rats and reduce ahf-induced oxidative stress.In addition, the results of western blot confirmed that lcz696 could upregulate the expression of nrf2 and ho-1 while decreasing keap1 expression.Conclusion.Lcz696 ameliorates isoproterenol-induced ahf in rats by alleviating oxidative stress injury and activating the nrf2 signaling pathway.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Laparoscopic Radical Resection versus Routine Surgery for Colorectal Cancer

For patients with colorectal cancer, minimally invasive surgical methods, particularly laparoscopic methods, are now the preferred course of therapy.This research is performed to investigate the effects of laparoscopic radical resection on patients with colorectal cancer.A total of 100 colorectal cancer patients treated in our hospital from january 2017 to january 2019 were enrolled.The subjects were divided into observation ( n = 50 ) and control ( n = 50 ) groups and treated with laparoscopic surgery and laparotomy, respectively.As well as postoperative complications and survival rates, the levels of inflammatory substances, stress response, immunological function, and perioperative markers were compared between the two groups.There was no significant difference in the postoperative exhaust time between the two groups ( p &gt; 0.05 ).Compared with the control group, the observation group showed longer operation time, faster recovery of intestinal function, shorter hospital stay, and less intraoperative bleeding amount ( p &lt; 0.05 ).The serum contents of hs-crp, tnf-α, il-6, norepinephrine, adrenaline, and cortisol at 1 d, 3 d, and 5 d after surgery were significantly higher than before in both groups ( p &lt; 0.05 ).Moreover, the serum contents of hs-crp, tnf-α, il-6, norepinephrine, adrenaline, and cortisol in the observation group were significantly lower than that in the control group ( p &lt; 0.05 ).At 10 days following surgery, immune index levels had dramatically increased in both groups, with noticeably higher immune index levels in the observation group than in the control group ( p &lt; 0.05 ).There were no appreciable differences in the two groups’ 2-year survival rates ( p &gt; 0.05 ), but the complication rate was much greater in the control group ( p &lt; 0.05 ).To sum up, after laparoscopic surgery, patients had fewer complications, shorter hospital stay, lower inflammatory factor expression, less stress response, better immune function, less trauma, faster recovery, and improved quality of life.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Knowledge, Attitude, and Practice regarding Narrative Medicine among Chinese Medical Personnel: An Online Cross-Sectional Survey

Narrative medicine has been applied as a model for humane medical practice in many countries.However, it was not introduced in china until 2011 and there has been no standardized assessment of chinese medical personnel regarding their perception and application of narrative medicine-related theories.This study is aimed at investigating chinese medical personnel’s knowledge, attitude, and practice regarding narrative medicine and the factors that influence it.Methods.An online questionnaire based on the knowledge, attitude, and practice model was distributed among chinese medical personnel from december 2021 to march 2022.All in-service medical personnel across china who had access to the internet were eligible.Two independent samples t -tests, one-way analysis of variance, pearson’s correlation analysis, and multivariate linear regression were conducted for data analyses.Results.The participants’ scoring rates for knowledge, attitude, and practice were 49.62%, 47.18%, and 41.43%, respectively.Significant influencing factors for knowledge were education level, religious belief, professional role, title, working years, and institution categories; those for attitude were education level, religious belief, professional role, and working years; and those for practice were professional title, religious belief, working years, and institution categories.Conclusions.Chinese medical personnel have generally good knowledge of, attitudes towards, and practice of narrative medicine; however, there remain deficiencies in their understanding of certain important concepts, their attitude towards narrative medicine, and the application of narrative skills in their daily work.Thus, to improve narrative medicine practice in china, the application of strategies based on theoretical, educational, and institutional aspects is warranted.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Key Technology of the Medical Image Wise Mining Method Based on the Meanshift Algorithm

Mean-shift originally refers to the mean vector of the offset.The algorithm idea is to assume that the data sets of different clusters conform to different probability density distributions, and the area with high sample density corresponds to the center of the cluster.With the wide application of hospital information system, especially the popularity of the meanshift algorithm in the outpatient system, it has greatly improved the efficiency of medical staff.Medical imaging refers to the technology and process of obtaining internal tissue images of the human body or a certain part of the human body in a noninvasive manner for medical treatment or medical research.It contains the following two relatively independent research directions: medical imaging system and medical image processing.In this paper, we expect to improve the mining ability of medical image information with the help of the meanshift algorithm based on the key technology of the medical image intelligent mining algorithm.This paper proposes a method to enhance image feature extraction and data mining and how to apply relevant analysis rules for mining.Applying this integrated algorithm to extract simplified rules is more beneficial to people’s understanding than the raw data and helps doctors quickly understand the patient’s condition.

Journal: Emergency Medicine International (2022)
Publication types: Research Article;
Keloid Core Factor CTRP3 Overexpression Significantly Controlled TGF- β 1-Induced Propagation and Migration in Keloid Fibroblasts

Keloid is a type of benign fibrous proliferative tumor characterized by excessive scarring.C1q/tnf-related protein 3 (ctrp3) has been proven to possess antifibrotic effect.Here, we explored the role of ctrp3 in keloid.In the current research, we examined the influence of ctrp3 on keloid fibroblasts (kfs) and investigated the potential molecular mechanism.Methods.Kf tissue specimens and adjacent normal fibroblast (nf) tissues were collected cultured from 10 keloid participants.For the tgf-β1 stimulation group, kfs were processed with human recombinant tgf-β1.Cell transfection of pc dna3.1-ctrp3 or pc dna3.1 was performed.The si rna of ctrp3 (si-ctrp3) or negative control si rna (si-scramble) was transfected into kfs.Results.Ctrp3 was downregulated in keloid tissues and kfs.Ctrp3 overexpression significantly controlled tgf-β1-induced propagation and migration in kfs.Col i, α-sma, and fibronectin m rna and protein levels were enhanced by tgf-β1 stimulation, whereas they were inhibited by ctrp3 overexpression.In contrast, ctrp3 knockdown exhibited the opposite effect.In addition, ctrp3 attenuated tgf-β receptors tri and trii in tgf-β1-induced kfs.Furthermore, ctrp3 prevented tgf-β1-stimulated nuclear translocation of smad2 and smad3 and suppressed the expression levels of p-smad2 and p-smad3 in kfs.Conclusion.Ctrp3 exerted an antifibrotic role through inhibiting proliferation, migration, and ecm accumulation of kfs via regulating tgf-β1/smad signal path.

Journal: Disease Markers (2023)
Publication types: Research Article;
Investigation on the Effect of Hemodialysis Combined with MDT Multimode Intervention on Renal Fibrosis Degree and Renal Function Improvement in Uremia Patients

The effect of hemodialysis combined with mdt intervention on the degree of renal fibrosis and renal function in uremia patients was studied.118 patients with uremia admitted to the hospital were selected as the research object, and they were divided into two groups according to the random number table method, 59 cases in the control group and 59 cases in the experimental group.The control group was treated with hemodialysis, and the experimental group was treated with mdt multimode intervention on the basis of hemodialysis.The differences in renal fibrosis, renal function, and satisfaction after treatment were compared before treatment and at 1, 3, and 6 months after treatment.The experimental results showed that hemodialysis combined with mdt multimode intervention in uremia patients could reduce renal fibrosis and improve renal function and improve clinical satisfaction evaluation.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Clinical Study;
Investigation on Imaging Features and Clinical Significance of Cardiac CT in Comprehensive Evaluation of Aortic Valve and Root before Percutaneous Aortic Valve Replacement

Medical imaging feature analysis is the basis of medical image processing and analysis.The solution of this problem not only directly affects the successful application of computer graphics and image technology in medicine but also has important theoretical and practical significance.In this paper, the imaging characteristics and clinical significance are discussed by studying the comprehensive evaluation of aortic valve and root before aortic valve replacement.In recent years, preoperative comprehensive evaluation of the aortic valve and root has been gradually carried out.Compared with traditional methods, minimally invasive surgery brings more accurate diagnosis to patients, quick recovery and discharge after surgery, and less pain.This study retrospectively includes patients with severe aortic stenosis who underwent tavr with routine computed tomography.Based on ct images, the determination and grouping of bicuspid aortic valve and tricuspid aortic valve were completed.Thirteen cross‐sectional levels of the aorta‐iliac‐femoral vascular access were completed.The results showed that 3 people had stroke (17.6%) and 5 people had myocardial infarction (29.4%) during the follow‐up period.Atrial fibrillation occurred in 5 patients (29.4%), permanent pacemaker implantation was performed in 1 patient (5.9%), and acute kidney injury occurred in 7 patients (41.2%).No patient died due to surgery‐related causes, and the analysis of imaging features and clinical significance in the preoperative comprehensive evaluation of the aortic valve and root played a crucial role.In the training stage, the principal component analysis method was used to train the shape, and the model of the shape intensity of the aortic valve and the shape change of each principal component was obtained.The most probable aortic valve region in the target image was obtained by matching the similarity of all atlases, and the correct aortic valve segmentation was obtained by using the first level set of shape intensity.The experimental part verified the accuracy of the algorithm.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Investigating the Effects of EMGBF Combined with Different Motion Directions on Improving Upper Limb Function, iEMC, and Pain in Patients with Shoulder Dislocation

The dislocation of the shoulder is a common complication of stroke, which is easy to occur after 3 months of stroke, with an incidence of 70%.There is no single standard for the pathogenesis of the disease, but the atrophy of the associated stability muscle, such as the triangle muscle, the oblique, and the upper muscle of the gonfield, may be the cause of the disease.In order to observe the effects of electromyographic biofeedback (emgbf) combined with different motion directions on upper limb function with shoulder dislocation, a total of 84 patients with shoulder dislocation from may 2020 to february 2022 are selected for the study.The experimental results show that after treatment, upper limb motor function, i emc, pain score, barthel index, and quality of life score in the observation group are significantly higher than those in the control group, with statistical significance.

Journal: Contrast Media & Molecular Imaging (2023)
Publication types: Clinical Study;
Investigating the Association between Orthopedic Fractures and Head Injury due to Road Traffic Accidents

Traumatic head injury (thi) due to road traffic accidents (rtas) is a global health problem.Studies exploring the association between rta-related thi and concurrent orthopedic fractures are lacking.We aim to provide a detailed analysis of this association and its impact on inhospital outcomes.Methods.Retrospective analysis of rta-related thi associated with orthopedic fractures admitted to a large tertiary center, southwest, saudi arabia, over ten years.Descriptive statistics for participant demographics and clinical outcomes were represented by percentages.The associations between head injury diagnosis or orthopedic fractures region and patient demographics are analyzed using the chi-square test.Post hoc analysis for the significant chi-square values was carried out by calculating the significant adjusted residuals.Adjust p value was obtained by using the benjamini-hochberg procedure to control for multiplicity testing.A p value less than 0.05 was considered statistically significant.Results.Concurrent orthopedic fractures are present in one-tenth of rta-related thi.The cohort was dominated by young males, with 46.5% of the population between 18 and 29 years old.There was a significant association between the head injury diagnosis and the region of orthopedic fracture ( p = 0.028 ).The type of head injury had significant associations with mortality and duration of hospital stay ( p = 0.039 and p = 0.037 , respectively).The region of orthopedic fracture significantly ( p = 0.018 ) affected the duration of hospital stay, with fractures in the clavicle/shoulder region significantly ( p = 0.035 ) having a short course of hospital admission.Conclusion.Orthopedic fractures concomitant with rta-related thi are common.The associations between the two injuries tend to happen in specific patterns.The inhospital stay duration and mortality significantly correlated with the site of the head or orthopedic injury.Knowledge of these patterns improves the care of thi victims, triaging, and resource allocations.

Journal: Applied Bionics and Biomechanics (2021)
Publication types: Research Article;