syedzayyan/paper_mill_benchmark huggingface dataset:
Optimization of Human Motion Recognition Information Processing System Based on GA-BP Neural Network Algorithm

At present, there are some problems in the process of human motion recognition, such as poor timeliness and low fault tolerance rate.How to effectively identify the motion process accurately has become a hot spot in the optimization system.In the existing research studies, the recognition accuracy is not very good and the response time is long.To end this issue, the paper proposed an information processing system and optimization method of human motion recognition based on the ga‐bp neural network algorithm.Firstly, a human motion recognition system based on dynamic capture recognition technology is designed, which realizes the recognition of motion information from common postures such as action span, speed change, motion trajectory, and other aspects in the process of human motion.Secondly, the proposed algorithm is used to comprehensively analyse and evaluate the motion state.Finally, experiments are designed to verify and analyse the results.Compared to some baseline methods in human motion recognition information systems, the system in this paper based on the ga‐bp neural network algorithm has the advantages of higher data accuracy and response speed, which can quickly and accurately identify the muscle group change in the process of human motion, and it can also provide customized motion suggestions based on the results.

Journal: Computational Intelligence and Neuroscience (2021)
Publication types: Research Article;
Opioid-Free Labor Analgesia: Dexmedetomidine as an Adjuvant Combined with Ropivacaine

Side effects of the use of opioid analgesics during painless delivery are the main factors that affect rapid postpartum recovery.Opioid use can result in dangerous respiratory depression in the patient.Opioids can also disrupt the baby’s breathing and heart rate.The nonopioid analgesic dexmedetomidine, a new a2-adrenergic agonist, possesses higher selectivity, greater analgesic effects, and fewer side effects.Moreover, epidural administration of dexmedetomidine also reduces local anesthetic consumption.Objective.Our study aims to compare the analgesic effects as well as the side effects of ropivacaine with dexmedetomidine against sufentanyl as an epidural labor analgesia.Methods.This study is a randomized, double-blinded, controlled trial (registration no.Chi ctr2200055360) involving 120 primiparous (a woman who has given birth once), singleton pregnancy women who are greater than 38 weeks into gestation and have requested epidural labor analgesia.The participants were randomized to receive 0.1% ropivacaine with sufentanyl (0.4 μg/ml) or dexmedetomidine (0.4 μg/ml).The primary outcomes included visual analogue score (vas), duration of first epidural infusions, the requirement of additional pcea bolus, and adverse reactions during labor analgesia.Results.Of the 120 subjects who consented, 91 parturient women (women in the condition of labor) had complete data for analysis.Demographics and vas, as well as maternal and fetal outcomes, were similar between the groups.The duration of first epidural infusions in dexmedetomidine was significantly longer than sufentanyl (median value: 115 vs 68 min, p &lt; 0.01); the parturient women who received dexmedetomidine and who required additional pcea bolus were fewer in comparison to those who received sufentanyl (27.5% vs 49.0%, p &lt; 0.05).Furthermore, the incidence of pruritus in the dexmedetomidine group was lower in comparison to the sufentanyl group (0% vs 11.8%, p &lt; 0.05).Conclusions.Dexmedetomidine, a nonopioid, is superior to the opioid analgesic sufentanyl in providing a prolonged analgesic effect as an epidural during labor.It also reduces local anesthetic consumption and has fewer side effects.The trial is registered with chi ctr2200055360.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Clinical Study;
Novel lncRNA AL033381.2 Promotes Hepatocellular Carcinoma Progression by Upregulating PRKRA Expression

Hepatocellular carcinoma (hcc) is a common malignant tumor that is characterized by aggressiveness and poor prognosis.Accumulating evidence indicates that oxidative stress plays a crucial role in carcinogenesis, whereas the potential mechanism between oxidative stress and carcinogenic effects remains elusive.In recent years, long noncoding rnas (lnc rnas) in cancers have attracted extensive attention and have been shown to be involved in oxidative stress response and carcinogenesis.Nevertheless, the roles of lnc rna al033381.2 in regulating the development and progression of hcc still remain unclear.The purpose of our study was to evaluate the potential effects and molecular mechanisms of al033381.2 that may be involved in oxidative stress response in hcc.Using bioinformatics analyses based on the tcga database, we screened and identified a novel lnc rna al033381.2 in hcc, which may be involved in oxidative stress responses.Q rt-pcr analysis revealed that al033381.2 is upregulated in hcc tissues.Through in vitro and in vivo experiments, we found that al033381.2 dramatically facilitates the growth and metastasis of hcc.Mechanistically, rna pull-down experiments, mass spectrometry, path arraytm, and rip were used to determine that al033381.2 binds to prkra and may be involved in al033381.2-mediated oncogenic functions in hcc cells.Moreover, rescue experiments demonstrated that prkra overexpression rescues the abilities of hcc cell proliferation, migration, and invasion that were affected by al033381.2 knockdown.Furthermore, we produced a nanoparticle-based si rna delivery system and tested its therapeutic effects in vivo.The results showed that the in vivo growth rate of the tumors treated with the nanoparticle/al033381.2 si rna complexes was dramatically lower than those treated with the nanoparticle/scramble si rna complexes.Taken together, our results suggest that the novel lnc rna al033381.2 may be involved in oxidative stress response by targeting oxidative stress-related genes in hcc.Al033381.2 plays vital oncogenic roles in hcc progression and may be a novel therapeutic marker for hcc diagnosis and treatment.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Network-Based Elaboration of the Efficacy of the Dachangshu (BL25) and Tianshu (ST25) Points in the Treatment of Functional Constipation in Children through Inflammation, Adipocytokine, or Leptin Pathways

Constipation commonly occurs during childhood, and more than 95% of cases are classified as functional constipation.If not effectively treated, 20% of patients with childhood constipation can continue to exhibit symptoms into adulthood, which seriously affects their mental health and quality of life.The main feature of acupuncture or acupoint stimulation, a special branch of traditional chinese medicine, is the selection of different acupoints for different diseases, and many worthy guidelines have been established for matching acupoints.The back-shu and front-mu point combination adheres to an important acupoint compatibility law that has been used since its proposal 2,500 years ago but has not yet been verified by the modern evidence-based experiments.This study focused on the back-shu and front-mu point combination using the dachangshu (bl25) and tianshu (st25) points as examples to explore possible research methods for network acupoint-based stimulation based on existing evidence and to elucidate the mechanisms induced by bl25 and st25 in the treatment of functional constipation in children (fcc).The study found that bl25 and st25 have 20 common targets, namely, aqp8, drd2, vip, tac1, il6r, tnf, fos, kit, chat, htr3a, gas8, sod3, trpv1, mpo, calca, il1b, p2rx7, npy2r, il10ra, and tph1, and these targets may provide a strategy for the combined usage of bl25 and st25.In addition, bl25 and st25 can affect fcc treatment through inflammation-related th17-cell differentiation, the nf-kappa b signaling pathway, and the toll-like receptor signaling pathway.Adipocytokines or leptin may also comprise the mechanism through which bl25 and st25 regulate fcc.In addition, bl25 and st25 regulate fcc through 13 core targets, namely, nfkbia, rela, tnf, ikbkb, irak1, tlr4, myd88, tnfrsf1a, il1r1, tlr2, il1b, traf6, and tnfrsf1b.In short, this study provides new ideas and methods for studying the mechanism of acupuncture points.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
The Role of Medical Big Data and Artificial Intelligence in the Diagnosis of Knee Osteoarthritis with Cardiovascular and Cerebrovascular Diseases

In this internet era, people use more and more network data, and hospital diagnosis is even more important.The improvement of medical standards has brought about the rapid growth of medical data.How to analyze related symptoms from a large amount of data performing an analysis and accurately diagnosing its symptoms has become one of the difficult problems.This article is aimed at studying the role of medical huge amount of data and artificial intelligence in the diagnosis of knee osteoarthritis combined with cardiovascular and cerebrovascular diseases.To this end, this article proposes to improve data mining methods and proposes a comprehensive analysis of patient data in the field of artificial intelligence for intelligent diagnosis and treatment so that doctors can make accurate judgments about the symptoms of patients and designed related experiments to explore its specific effects.The experimental results in this article show that the improved data mining speed has increased by 17%, the data integrity has increased by 31%, and the proportion of valid data has also increased by 23%, which is very effective for clinical diagnosis.

Journal: Wireless Communications and Mobile Computing (2022)
Publication types: Research Article;
The Influence of Cultural Communication on the Psychological Health of University Students in the Environment of Big Data

With the progress of information technology and internet technology, many new media communication technologies are also progressing, and university students are at the forefront of the development of the internet and the application of cultural communication.Therefore, the impact of modern cultural communication on college students is the most obvious.Time culture communication relies on time communication media, which affects university students’ psychological cognition, experience, and mental health level.University students are the high‐risk group of mental health problems.At present, most college students are mentally healthy.However, a considerable number of students’ mental health is not optimistic.Therefore, paying attention to the impact of culture on college students’ mental health plays an important role in the healthy growth of college students.However, a considerable number of students’ psychological health is not optimistic.Therefore, paying attention to the impact of culture on university students’ psychological health plays an important role in the healthy growth of university students.In this article, 300 university students were randomly selected as the subjects of this study.Scl‐90 test and related factors were used to investigate, covering 9 factors.Five common classification algorithms were trained with training sets and evaluated through verification sets.The classifier with the best effect was selected as our algorithm; it is used to discern students with psychological health problems in the test set.The experipsychological results show that precision reaches 0.68, recall reaches 0.56, and f1 measure reaches 0.67.Based on the influencing factors of university students’ psychological health, through the analysis of random samples, based on family environment, school environment, community environment, information culture environment, and other factors, this article puts forward strategies to create a warm and progressive family environment, a friendly and positive campus environment, a democratic and scientific community education environment, and a civilized and fair legal environment, so as to properly solve the psychological health problems of university students.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
The Impact of Agricultural Land Rights Policy on the Pure Technical Efficiency of Farmers’ Agricultural Production: Evidence from the Largest Wheat Planting Environment in China

Although the clarification of property rights for agricultural land has the potential to enhance agricultural production efficiency and support its sustainable growth, this goal may not always be met in reality.As a result, the emphasis of this study is on the elements that affect agricultural output.It also examines how the stability of land rights affects agricultural production efficiency and, most importantly, how the heterogeneity of farmers’ perspectives affects this process.Through the empirical test using the data of farmers in henan province, the largest wheat area in china, the results show that: (1) the farmland confirmation policy significantly promotes the improvement of the pure technical efficiency of agricultural production, a series of robustness tests, and the treatment of endogenous problems, which also confirmed the robustness of the results.(2) in the allocation of factors, agricultural investment and credit acquisition have been proved to be important influencing mechanisms, while labor and land transfer have not played a mechanistic role.(3) heterogeneity analysis shows that the self‐service of farmers choosing to purchase agricultural machinery is more efficient than purchasing outsourcing services; the agricultural production of farmer households without hired workers has a significant technical efficiency, but the impact on farmer households with hired workers is not significant; for farmer households with agricultural insurance purchase behavior, purchase willingness, and planting and breeding advantages, the farmland ownership confirmation policy can play a more important role in promoting the pure technical efficiency of agricultural production; the promotion effect of the farmland right confirmation policy on the pure technical efficiency of agricultural output is strongest when there is a smaller level of farmers operating on a part‐time basis and when more farmers prioritize profit maximization as the production goal.Corresponding policy recommendations are made at the conclusion of the study in light of the conclusions mentioned.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
Proteomics Analysis of Serum Proteins in Gestational Diabetes

The purpose of this study was to screen serum proteins for biomarkers of gestational diabetes mellitus (gdm) and to investigate its pathogenesis by analyzing the differences in serum proteomics between pregnant women with gdm and healthy pregnant women.Methods.Patients who were admitted to the first affiliated hospital of fujian medical university from june 2019 to january 2020 were included.According to the medical history and the results of the 75 g oral glucose tolerance test (ogtt), they were divided into the normal pregnant women group and gdm pregnant women group.The serum of two groups of patients was collected.High performance liquid chromatography-mass spectrometry was used to identify differentially expressed serum proteins between pregnant women with gdm and healthy pregnant women, and bioinformatics analysis was then performed on the identified proteins.Results.A total of 1152 quantifiable proteins were detected; among them, 15 were upregulated in serum of gdm pregnant women, while 26 were downregulated.The subsequent parallel reaction monitoring (prm) assay validated the expression levels of 12 out of 41 differentially expressed proteins.Moreover, bioinformatics analysis revealed that the differentially expressed proteins are involved in multiple biological processes and signaling pathways related to the lipid metabolism, glycan degradation, immune response, and platelet aggregation.Conclusions.This study identified 41 serum proteins with differential expression between pregnant women with gdm and healthy pregnant women, providing new candidate molecules for elucidating gdm pathogenesis and screening therapeutic targets.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Clinical Study;
Progress of Proprioceptive Training in the Treatment of Traumatic Shoulder Instability

In individuals with traumatic shoulder instability, there is a loss of proprioception.This paper reviews the academic literature on shoulder instability and functional impairment in recent years and combines it with clinical practice experience to summarize several techniques of proprioceptive regeneration following traumatic shoulder instability.Many issues were discovered, including a lack of literature on the role of sensory input, a lack of basic proprioceptive research, insufficient sample size in proprioceptive research, and a lack of systematic and standardized standards for the evaluation and training of proprioception in clinical practice, among others.In the future, we will need to better understand the mechanism of proprioception and conduct research on various groups of people, with a focus on discussing the optimal intensity, frequency, and duration of various training methods, as well as implementing proprioceptive training in stages throughout the rehabilitation process.The reestablishment of shoulder joint function, the restoration of proprioception, and the enhancement of daily activities are all critical.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Prediction of Employment Index for College Students by Deep Neural Network

With the acceleration of popularization of higher education in china and the intensification of employment difficulties for college graduates, the employment field has gradually widened, the number of entrepreneurs has gradually increased, and the regional differences are obvious.The employment difficulty of college graduates has aroused wide-spread concern in the society.Therefore, the convolution neural network (cnn) is used to establish a prediction and evaluation model for the employment development trend of college graduates in this paper.The feasibility and practicability are proved by a case, which is of great significance for the government and colleges to provide decision-making support and suggestions to solve the problem of difficult employment.

Journal: Mathematical Problems in Engineering (2022)
Publication types: Research Article;
Perioperative Management and Long-Term Outcomes in Ocular Cicatricial Pemphigoid Patients Undergoing Cataract Surgery

To observe the outcomes of cataract surgery in ocular cicatricial pemphigoid (ocp) patients and explore routine perioperative medical treatments.Design.Retrospective case series.Methods.Fourteen eyes of 8 patients were included in the study.Foster’s stage 1-4 ocp patients were given human intravenous immunoglobulin, whereas patients with active inflammation were treated with prednisone tablets and methotrexate.Those who were intolerant to methotrexate and had severe inflammatory symptoms were treated with cyclophosphamide.Cataract surgery was performed for all patients after three months of systemic treatment under stable conditions.The conjunctival biopsy was evaluated by immunofluorescence microscopy.Then, patients were divided into individuals with or without ankyloblepharon.Records were reviewed for ocp stage, type of surgery, best-corrected visual acuity (bcva), schirmer i test, corneal fluorescein sodium staining, meibomian gland coloboma range, and ocular surface disease index (osdi) scores.Follow-up was for the duration of taking topical and systemic medication.Results.Nine female (64.29%) and 4 male (35.71%) eyes were diagnosed with ocp by biopsy.The mean follow-up time was 60.64 ± 35.62 months.Thirteen eyes (92.86%) of 7 patients underwent phacoemulsification.One eye underwent phacoemulsification combined with amniotic membrane transplantation.The intracapsular extraction of cataract was applied to one eye.The bcva improved significantly in all the patients, which remained stable until the last follow-up.The schirmer i test was higher than that before the surgery.Corneal fluorescein sodium staining after surgery showed a decrease in score compared to the preoperative score.The bcva of the patients after surgery increased significantly.The osdi scores of patients with ankyloblepharon were significantly higher than for those without it.Postoperative symblepharon showed no significant difference compared to the preoperative symblepharon.Conclusions.In this series, ocp patients with cataracts were able to undergo phacoemulsification surgery, whereas routine use of immunosuppression and closed postoperative follow-up were necessary.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Clinical Study;
miR-190a-3p Promotes Proliferation and Migration in Glioma Cells via YOD1

Introduction.To investigate the function of mi r-190a-3p on the proliferation and migration of glioma.Methods.Twenty glioma samples and 6 normal brain tissue samples were collected.Normal human glial cell line heb and glioma cell lines were used for the experiments.We then used target scan to predict the target genes of mi r-190a-3p.Dual-luciferase reporter assay was also used to validate.Results.Combined with dual-luciferase reporter experiment, we finally verified that yod1 was the aim, and it was low-expressed in glioma.Besides, a series of mechanism experiments then proved that mi r-190a-3p negatively regulates yod1 expression.Conclusions.Our research was the first to demonstrate the promoting function of mi r-190a-3p in the proliferation and migration of glioma and provided new views for the treatment of glioma.Mi r-190a-3p was expected to be a new target for molecular therapy of glioma.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
miR-18a-5p Targets FBP1 to Promote Proliferation, Migration, and Invasion of Liver Cancer Cells and Inhibit Cell Apoptosis

Liver cancer is one of the most aggressive malignant tumors.It is significant to understand the molecular mechanism of liver cancer cells to develop new treatment plans.Studies have identified that fbp1 serves as a cancer inhibitor gene.To research the effect mechanism of fbp1 in liver cancer cells, bioinformatics analysis was performed to study its expression in liver cancer tissue.Survival analysis was also performed.Moreover, star base database was applied to predict upstream regulatory genes of fbp1.Dual-luciferase assay was performed to testify their targeted relationship.The m rna and protein expression levels of fbp1 in liver cancer cells were detected by q rt-pcr and western blot, respectively.Cell viability was analyzed by cck-8 assay.The migratory and invasive abilities of cells were analyzed by transwell assay.The apoptosis of liver cancer cells was detected by flow cytometry.The results showed that the expression of fbp1 was downregulated in liver cancer tissue and cells.Fbp1 low expression was correlated with the poor prognosis of patients.Mi r-18a-5p could inhibit fbp1 expression.Overexpression of fbp1 could inhibit the progression of liver cancer cells and promote cell apoptosis.Overexpressing mi r-18a-5p could promote the progression of liver cancer cells and inhibit cell apoptosis.However, overexpressing fbp1 simultaneously could reverse the effect.Mi r-18a-5p and fbp1 are expected to be candidates for liver cancer treatment.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;