syedzayyan/paper_mill_benchmark huggingface dataset:
Smart Healthcare System for Severity Prediction and Critical Tasks Management of COVID-19 Patients in IoT-Fog Computing Environments

Covid-19 has depleted healthcare systems around the world.Extreme conditions must be defined as soon as possible so that services and treatment can be deployed and intensified.Many biomarkers are being investigated in order to track the patient’s condition.Unfortunately, this may interfere with the symptoms of other diseases, making it more difficult for a specialist to diagnose or predict the severity level of the case.This research develops a smart healthcare system for severity prediction and critical tasks management (shssp-ctm) for covid-19 patients.On the one hand, a machine learning (ml) model is projected to predict the severity of covid-19 disease.On the other hand, a multi-agent system is proposed to prioritize patients according to the seriousness of the covid-19 condition and then provide complete network management from the edge to the cloud.Clinical data, including internet of medical things (io mt) sensors and electronic health record (ehr) data of 78 patients from one hospital in the wasit governorate, iraq, were used in this study.Different data sources are fused to generate new feature pattern.Also, data mining techniques such as normalization and feature selection are applied.Two models, specifically logistic regression (lr) and random forest (rf), are used as baseline severity predictive models.A multi-agent algorithm (maa), consisting of a personal agent (pa) and fog node agent (fna), is used to control the prioritization process of covid-19 patients.The highest prediction result is achieved based on data fusion and selected features, where all examined classifiers observe a significant increase in accuracy.Furthermore, compared with state-of-the-art methods, the rf model showed a high and balanced prediction performance with 86% accuracy, 85.7% f-score, 87.2% precision, and 86% recall.In addition, as compared to the cloud, the maa showed very significant performance where the resource usage was 66% in the proposed model and 34% in the traditional cloud, the delay was 19% in the proposed model and 81% in the cloud, and the consumed energy was 31% in proposed model and 69% in the cloud.The findings of this study will allow for the early detection of three severity cases, lowering mortality rates.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Reversing Postcardiopulmonary Bypass Associated Cognitive Dysfunction Using k-Opioid Receptor Agonists to Regulate Microglial Polarization via the NLRP3/Caspase-1 Pathway

Cardiopulmonary bypass (cpb) is mainly used during cardiac surgeries that treat ischemic, valvular, or congenital heart disease and aortic dissections.The disorders of central nervous system (cns) that occur after cardiopulmonary bypass are attracting considerable interest.Postoperative neurocognitive disorders (pnd) have been reported as the leading cause of patients’ disability and death following cpb.The k-opioid receptor (kor) agonists (u50488h) have been suggested to be vital in the treatment of surgically induced cns neuroinflammatory responses.In this article, the transitions between the m1 and m2 microglial polarization state phenotypes were hypothesized to significantly affect the regulatory mechanisms of kor agonists on postcardiopulmonary bypass (post-cpb) neuroinflammation.We investigated the effects of u50488h on neuroinflammation and microglia polarization in rats exposed to cpb and explored the method of the nlrp3/caspase-1 pathway.Thirty sd rats were randomly divided into three groups: sham operation group, cardiopulmonary bypass model group, and cpb+ k-opioid receptor agonist (u50488h) group, with ten rats in each group.The morris water maze was used to evaluate the changes in the cognitive function of cpb rats.Hematoxylin and eosin (he) staining and tunel were performed to assess the rats’ hippocampal damage.Enzyme-linked immunosorbent assay (elisa) was used to detect changes in brain injury markers and inflammatory factors.Furthermore, immunofluorescence was used to observe the expression of microglia polarization and nlrp3 followed by western blots to detect the expression of the nlrp3/caspase-1 pathway and microglia polarization-related proteins.Rat microglia were cultured in vitro, with lps stimulation, and treated with u50488h and a caspase-1 antagonist to evaluate the effects and mechanism of action of u50488h.Kors alleviated hippocampal damage caused by cpb and improved pnd.Cpb activated the nlrp3 inflammasome and upregulated pro-caspase-1 expression which promoted the expression of pro-il-lβ and pro-il-18 and resulted in increased inflammation.However, kors also inhibited nlrp3 and transformed microglia from the m1 to the m2 state.Caspase-1 inhibitor treatment reduced the microglial polarization induced by kors.The κ-opioid receptor agonists inhibited the inflammation mediated by microglia and improved pnd through the nlrp3/caspase-1 signaling pathway.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Application of Support Vector Machine Model Based on Machine Learning in Art Teaching

The purpose of the evaluation is to reflect on whether education provides a good environment and conditions for the development of students and to reflect on the effect of teaching and the practicability of the talents cultivated by teaching to the society.When art education is evaluated, a number of positive outcomes have been achieved in terms of the development of art education, including the improvement of art education as a whole, the development of art talent, and a stronger role for the educational and social communities concerned about the quality of art education.Machine learning-based support vector machine (svm) can better tackle issues like nonlinearity, high dimensionality, and local minima, which have been effectively implemented in the area of teaching quality evaluation (tqe) with the fast growth of information technology and the internet.The main work of this paper is as follows: (1) it briefly expounds the research progress of tqe and multiclassification algorithm based on svm at home and abroad and introduces the relevant basic theories of these two aspects.(2) one-to-one combination method is used in this research, reducing training time to a certain degree.Tests prove the procedure to be objective and equitable.(3) this research claims that an art tqe approach based on svm is suited for limited professional assessment sample data and provides a method for this purpose.

Journal: Wireless Communications and Mobile Computing (2022)
Publication types: Research Article;
Research Progress of B-Cell Lymphoma/Leukemia-2 Inhibitor Combined with Azacytidine in the Targeted Therapy of Acute Myeloid Leukemia

To investigate the efficacy and safety of azacytidine and b-cell lymphoma/leukemia-2 inhibitors in the treatment of patients with acute myeloid leukemia (aml) and myelodysplastic syndrome (mds).Methods.The clinical data of 31 patients with aml/mds who were clearly diagnosed with aml/mds were analyzed from 2018.10 to 2021.02, and the total amount of azacyclonol and b-cell lymphoma/leukemia-2 inhibitor was used for single or combined chemotherapy, with a total amount of 75 mg/m2 ∗ 7 d, divided into 7-10 days of continuous subcutaneous injection, every 28-30 days for a course of treatment.Overall response rate (orr), median survival, poor response, and genetic mutations were observed.Results.A total of 104 courses of treatment were completed in 31 patients, the median course was 3 (1–12), and 6 patients who did not complete 2 courses of treatment were not counted in the statistics.After 2 courses, orr was 72.0%, cres was 2 (8.0%), m cr was 16 (64.0%), disease stable was 5 (20.0%), treatment failures were 2 (8.0%), mortality was 40.0%, and median survival time was &gt;5 months.Single-agent and combined orr was 64.3% and 81.8%, respectively, with median survival of 7.25 and 9 months; orr for mds and aml was 66.7% and 76.9%, respectively, median survival of 8 and 11 months was 66.7% and 80.0% of orrs at 260 and v60 years, respectively, and median survival of 7 and 11.5 months; mds-eb-1.The orr of mds-eb-2 was 75.0% and 62.5%, respectively, with median survival times of 11.5 and 6.5 months.During 2 courses and 4 courses, the rate of transfusion dependence was 64.0% and 55.5%, respectively.Fifteen cases were detected by second-generation sequencing, and the results were 14 cases of combined gene mutations.Conclusion.Azacytidine and b-cell lymphoma/leukemia-2 inhibitors have good efficacy and high safety in the treatment of aml and mds, and the combined treatment is better than that of monotherapy, but the side effects of combination therapy are large.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Relationship between Quantitative Parameters of Echocardiography and Vascular Endothelial Function in Patients with Chronic Heart Failure and Its Predictive Value for Short-Term MACE Risk

To investigate the relationship between quantitative parameters of echocardiography and vascular endothelial function in patients with chronic heart failure (chf) and the predictive value of short-term major adverse cardiovascular events (mace).Methods.From february 2018 to february 2020, 86 chf patients in our hospital were selected as the observation group, and 46 healthy subjects were selected as the control group during the same period.Quantitative parameters of echocardiography (left ventricular ejection fraction (lvef), left ventricular short-axis shortening rate (fs), and ratio of peak flow velocity between early and late mitral valve diastole (e/a)) and endothelial function indexes (endothelin-1 (et-1)/nitric oxide (no)) were compared between the two groups.The correlation between quantitative parameters of echocardiography and vascular endothelial function in patients with chf was analyzed.A logistic regression equation was used to analyze the risk factors of mace in patients with chf.The receiver operating characteristic curve (roc) was used to analyze the predictive value of quantitative parameters of echocardiography and no/et-1 for the risk of mace in patients with chf.Result.Lvef, fs, and no/et-1 in the observation group were lower than those in the control group, while e/a was higher than that in the control group ( p &lt; 0.05 ).In chf patients, lvef and fs were positively correlated with no/et-1, while e/a was negatively correlated with no/et-1 ( p &lt; 0.05 ).Logistic regression analysis showed that the decrease of lvef, fs, no/et-1, and e/a were risk factors for mace ( p &lt; 0.05 ) after adjusting for age, body mass index, and cardiac function grading.The auc value of short-term mace predicted by quantitative parameters of echocardiography and no/et-1 combined was 0.883, with a corresponding sensitivity of 86.21% and specificity of 73.13%.Conclusion.Quantitative parameters of echocardiography in chf patients are related to vascular endothelial function, and their combination can effectively predict the risk of mace in the near future, providing reference for clinical treatment.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Research Article;
Relationship between Coronary VH-IVUS Plaque Characteristics and CTRP9, SAA, and Hcy in Patients with Coronary Heart Disease

Coronary heart disease is a common disease threatening human health.In recent years, the incidence of coronary heart disease in china has only increased.It is the most common type of organ disease caused by coronary atherosclerosis, which is observed in the aorta, carotid artery, and femoral artery.The main clinical treatments for coronary heart disease include coronary artery bypass grafting and drug treatment.To investigate the relationship of serum adipocytokine c1q/tumor necrosis factor-related protein 9 (ctrp9), amyloid a (saa), and plasma homocysteine (hcy) with coronary artery plaque characteristics in patients with coronary heart disease.Overall, 143 patients with coronary heart disease admitted to our hospital are selected as research participants.The proportion of plaque necrosis core volume is higher in group a than in group b, and the differences are statistically significant ( p &lt; 0.05 ).In group a, necrotic core volume percentage is negatively correlated with ctrp9 levels and positively correlated with saa and hcy levels ( p &lt; 0.05 ).Logistic regression analysis revealed that increased systolic blood pressure, increased number of coronary artery lesions, decreased ctrp9 levels, and increased hcy levels are independent risk factors for thin fibrous cap atherosclerosis in patients with coronary heart disease ( p &lt; 0.05 ).Decreased ctrp9 levels and increased hcy levels are independent risk factors for coronary heart disease patients with thin fibrous cap atherosclerosis.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Reduced Incidence of Necrotizing Enterocolitis due to the Anti-Inflammatory Effects of CXCL14 in Intestinal Tissue

Bioinformatic analysis indicated that downregulated cxcl14 will occur in the intestinal tissue of patients with necrotizing enterocolitis (nec).To reveal the relationship between cxcl14 and mucosal immune regulation, we designed and implemented the experiments to explore the potential function of cxcl14 in the pathogenesis of nec.Firstly, this study confirmed that the expression of cxcl14 decreased in the intestinal tract of nec children.Secondly, the experiments results showed that cxcl14 could ameliorate the inflammatory injury of intestinal tissue through the suppressive effect on the expression of tnf-α and inf-γ in vivo.Finally, we explained that activation of the tlr4 can reduce the expression level of cxcl14 in the intestinal tissue of mouse pups.Collectively, our study suggested that cxcl14 may negatively regulate the inflammatory response in intestinal tissue and play an essential role in nec development and progression.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Real-Time Monitoring of Intraocular Pressure in Glaucoma Patients Using Wearable Mobile Medicine Devices

Glaucoma is caused by excessive aqueous humor in the eye, resulting in a continuous or intermittent increase of intraocular pressure, which exceeds the tolerance of the eyeball and damages the optic nerve.Existing treatments for glaucoma do not work well or have significant side effects.Intraocular pressure signal is a very important physiological signal that needs real-time and accurate monitoring in glaucoma patients, especially in severe glaucoma patients.Therefore, long-term, real-time, and accurate monitoring of intraocular pressure is of great significance for the diagnosis and treatment of glaucoma patients.The use of wearable devices for real-time ocular diagnosis and treatment of glaucoma patients is an effective approach.However, the current commonly used intraocular pressure measurement and monitoring technology is difficult to meet the diagnosis and monitoring needs of glaucoma patients in terms of size, measurement accuracy, power consumption, and intelligence.Therefore, facing the needs of glaucoma disease treatment, this topic studies an implantable flexible intraocular pressure sensor for long-term continuous monitoring of intraocular pressure in glaucoma patients and mainly focuses on the working principle, structural design, process fabrication, measurement and control system, characterization, and performance test of the intraocular pressure sensor.It is of great significance for personalized and accurate treatment of glaucoma patients.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Qing Zao Fang (QZF) Alleviates the Inflammatory Microenvironment of the Submandibular Gland in Sjögren’s Syndrome Based on the PI3K/Akt/HIF-1α/VEGF Signaling Pathway

Sjögren’s syndrome (ss) which could lead to a disorder of our immune system is a chronic autoimmune disease characterized by invading exocrine glands such as salivary glands and lacrimal glands and other exocrine glands.Its common symptom is dry mouth and dry eyes, often accompanied by a large number of lymphocyte infiltrations and can involve other organs to cause complex clinical manifestations.In this study, we aimed at investigating the effect of qzf in ss, identifying the molecular mechanism in modulating autoimmune response, and determining the important roles of these factors’ function as a modulator in the pathogenesis of ss.The nod mice were utilized to establish the rats’ model of sjögren’s syndrome.After 10 weeks’ hydroxychloroquine and qzf in different dose interference, submandibular gland tissue was collected.The therapeutic effect of qzf on ss rats was identified, and the results suggest the comparable potential to hydroxychloroquine.In submandibular gland tissue, interleukin- (il-) 17 was significantly lower in high-dose qzf than that in ss rats and the focal lymphocytes were highly attenuated.Moreover, we found that pi3k/akt signals were activated and the downstream hif-1α/vegf signals were enhanced in ss rats whose protein expression could be inhibited by qzf treatment.In addition, qzf could modulate autophagy in submandibular gland tissue and then inhibit the inflammation response and therefore facilitate the tissue repair.

Journal: Disease Markers (2022)
Publication types: Research Article;
Punicalagin Alleviates Aged Bronchial Asthma by Inhibiting Th2 Differentiation through IL-4/STAT6 and Jagged1/Notch Pathways

To explore the therapeutic effect and mechanism of punicalagin on bronchial asthma in the elderly.Methods.Peripheral venous blood was collected from healthy people and elderly patients with bronchial asthma.Peripheral blood mononuclear cells (pbmcs) were isolated and cultured.Pbmcs in the patient group were treated with different concentrations (0, 50, 100, and 200 mg/l) of punicalagin (pun).Mtt assay was used to detect cell activity, elisa was used to detect the levels of ifn-γ, il-2, il-4, and il-5, and western blotting was used to detect the protein levels of p-stat6, jagged1, and gata3.Result.Mtt results showed that 50–200 mg/l pun had no cytotoxicity to pbmcs within 24 h.Elisa results showed that the levels of ifn-γ and il-2 in the serum of the patients were significantly lower than those of healthy people, and the levels of il-4 and il-5 were significantly higher than those of the healthy people.Pun treatment significantly increased the levels of ifn-γ and il-2 in the supernatant of pbmcs culture, while significantly decreased the levels of il-4 and il-5, and the change was proportional to the concentration of pun.Western blotting results showed that the levels of p-stat6, jagged1, and gata3 protein in pbmcs of patients were significantly higher than those of the healthy people.Pun treatment could significantly reduce the expression of p-stat6, jagged1, and gata3 protein in pbmcs of patients, and the reduction level was proportional to pun concentration.Conclusion.Pun can inhibit th2 differentiation and regulate th1/th2 balance by regulating il-4/stat6 and jagged1/notch pathways to alleviate the progress of bronchial asthma in the elderly.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Progesterone Reduces ATP-Induced Pyroptosis of SH-SY5Y Cells

To investigate the mechanism of progesterone inhibiting the scorch death of sh‐sy5y cells induced by exogenous adenosine triphosphate (atp).Methods .Sh‐sy5y cells with good logarithmic growth were used in the experiment.The cells were randomly divided into 5 groups: normal control group, dmso group, bbg group, atp group, and atp+progesterone group.The cell survival rate of each group was measured by cck‐8 method.The expressions of p2x 7 receptor, caspase‐1, caspase‐11, and il‐1 β were detected by western blotting.Results .(1) after sh‐sy5y cells were treated with atp at different concentrations (1, 3, 6, and 9 mmol/l) for 2 hours, the cell survival rate decreased in a concentration‐dependent manner compared with the normal blank group.The results showed that the optimal lethal concentration of atp was 6 mmol/l.Sh‐sy5y cells were preincubated with progesterone at different concentrations (3, 10, 30, and 100 nmol/l) for 30 minutes and then incubated with 6 mmol/l atp.The cell survival rate of this group was significantly improved ( p &lt; 0.01).The optimal concentration of progesterone to improve cell survival and inhibit cell death was 30 nmol/l.(2) compared to the control group, there was no significant difference ( p &gt; 0.05) in p2x 7 receptor, caspase‐1, caspase‐11, and il‐1 β with the dmso group (0.001% dmso, 24 h) and bbg group (bbg1 mmol/l, 24 h).(3) in the atp group, the expression of p2x 7 receptor and caspase‐1 (the key protein of classical cell death pathway) increased significantly ( p &lt; 0.01), which was related to inflammatory factor il‐1 β with consistent performance ( p &lt; 0.01).There was no significant change in caspase‐11 (the key protein of nonclassical focal death pathway) ( p &gt; 0.05).(4) the expression of p2x 7 receptor, caspase‐1, and inflammatory factor il‐1 β in the progesterone+atp group was significantly downregulated ( p &lt; 0.01).There was no significant change in caspase‐11 ( p &gt; 0.05).Conclusion .Certain dose of progesterone can inhibit the focal death of sh‐sy5y cells induced by extracellular high concentration atp.It can reduce the expression of p2x 7 receptor, inhibit the conduction pathway of cell death, reduce the release of inflammatory factor il‐1 β , and improve cell survival.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Preliminary Study on the Evaluation of Multimodal Effects of Type 2 Diabetic Nephropathy

In order to explore the factors of patients with type 2 diabetic nephropathy (dn), in this paper, 257 patients with type 2 diabetic nephropathy in zhejiang province were observed, with 156 males and 101 females.The age range was 53–69 years old.According to the ratio of urine albumin/creatinine, it was divided into two groups: the diabetic nephropathy group and the nondiabetic nephropathy group.Age, diabetic course, hypertension, body mass index, glycated hemoglobin, total gallbladder alcohol, high-density lipoprotein, and low-density lipoprotein were compared.The results showed that diabetic diseases, hypertension, hba1c, and ldl-c were independent risk factors for diabetic nephropathy, and hdl-c was the independent protection factor of dkd ( p &lt; 0.05 ).Therefore, malnutrition and microinflammatory state are the risk causes of the quality of life and survival rate of type 2 diabetic nephropathy mhd patients and actively improve nutritional status.Reducing the status of microinflammatory disease is especially important.

Journal: Scientific Programming (2021)
Publication types: Research Article;