syedzayyan/paper_mill_benchmark huggingface dataset:
Salviae miltiorrhizae Liguspyragine Hydrochloride and Glucose Injection Protects against Myocardial Ischemia-Reperfusion Injury and Heart Failure

Myocardial ischemia-reperfusion (mir) injury is a common stimulus for cardiac diseases like cardiac arrhythmias and heart failure and may cause high mortality rates.Salviae miltiorrhizae liguspyragine hydrochloride and glucose injection (sgi) has been widely used to treat myocardial and cerebral infarctions in china even though its pharmacological mechanisms are not completely clear.Methods.The protective effect and mechanism of sgi on mir injury and heart failure were investigated through the h9c2 cell model induced by hypoxia/reoxygenation (h/r) and rapamycin, zebrafish model induced by h/r and isoprenaline, and rat mir model.Results.Sgi significantly reduced the infarct size and alleviated the impairment of cardiac functions in the mir rat model and h/r zebrafish model and promoted cell viability of cardiomyocyte-like h9c2 cells under h/r condition.Consistently, sgi significantly downregulated the serum level of biomarkers for cardiac damage and attenuated the oxidative damage in the mir and h/r models.We also found that sgi could downregulate the increased autophagy level in those mir and h/r models since autophagy can contribute to the injurious effects of ischemia-reperfusion in the heart, suggesting that sgi may alleviate mir injury via regulating the autophagy pathway.In addition, we demonstrated that sgi also played a protective role in the isoproterenol-induced zebrafish heart failure model, and sgi significantly downregulated the increased autophagy and sp1/gata4 pathways.Conclusion.Sgi may exert anti-mir and heart failure by inhibiting activated autophagy and the sp1/gata4 pathway.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Research on Cardiorespiratory Endurance Test and Training Method Based on Structural Equation Model

In order to study the cardiorespiratory endurance test and training method under the structural equation model, a structural equation model built in conjunction with anos7.0 is proposed.This method uses confirmatory factor analysis and analyzes the influencing factors of motor skills.Studies indicate that df = 173 &gt; 0 of the structural equation model, to over-identify the model, the absolute value of the standardized coefficient value is 0.257 to 0.758, less than 0.95, and there is no value with a large estimated standard deviation.The model did not violate the estimation phenomenon.Among the factors affecting motor skills, cardiopulmonary function, and muscle endurance, the weight of the back muscles is less than 0.4, the power of coordination and explosive power of lower limbs is greater than 0.6, and limb muscle strength, body mass, and the stretch and flexibility of the muscles have a greater weight on basketball skills than 0.5.The structural equation model is an over-recognition model.The absolute value of the standardized coefficient value does not have a value with an excessively large standard deviation estimate, and the model does not violate the estimate.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Pulmonary Magnetic Resonance Imaging Replaces Bedside Imaging in Diagnosing Pneumonia in Infants

Neonatal bronchopulmonary bedside photography (nbbp) evaluates the consumption of lung magnetic resonance imaging as a replacement for bedside imaging in diagnosing infant pneumonia.In premature baby respiratory support, neonatal bronchopulmonary (nb) is one of the most dangerous consequences of accurate diagnosis that impact health alternatives once steroids are administered.Infants may experience eating issues and vomit if their condition is bad enough; lower birth weight, younger gestational age, and extensive breathing tube damage are the most frequently established risk factors as a component of a neonatal habitat.This paper introduces the intelligent medical care (imc) for neonatal bronchopulmonary bedside photography (nbbp), which enhances various preventive efforts such as prenatal steroid therapy.Because of many prenatal and postnatal variables, growth hormone and diet nutrients influence alveolar and vascular development.For the future prevention of nb, it is more likely that a combination of different therapies working on diverse causal pathways would be beneficial.This research in nbbp‐imc technology that enhances prenatal care medicines are the most excellent and effective treatments for all these neonates throughout the decades.As a result, premature babies at risk for nb may benefit from the findings of this research, which experts anticipate can inspire further studies in the area.The purpose of this paper is to emphasize the work performed to improve respiratory outcomes for babies at risk of nb and to place this work in perspective with relevant research currently being conducted simultaneously.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Innovative Design of Intelligent Health Equipment for Helping the Blind in Smart City

The rapid advancement of information technology in today’s modern society is contributing to an increase in the general degree of civilization in society.People are pleased with technological progress, but they are also becoming more aware that a major challenge confronting the advancement of social civilization at the moment is determining how to alleviate the difficulties associated with traveling and participating in social activities for the blind, as well as increasing the frequency with which they go out, travel, and participate in other activities.The blindness equipment that is now accessible in china is no longer suitable to meet the needs of blind people, but the growth of smart cities offers an opportunity to change this.Guide devices are crucial among the numerous types of equipment to assist the blind, and in order to better fulfill their various demands, we must upgrade and optimize the existing devices.The chinese people’s daily highlights some of the key barriers to blind people’s access in its 2019 article: random parking that blocks blind lanes; and “snake” and “broken” blind lanes that are not created with blind people’s access in mind.In a smart city, accurate placement via smart maps helps alleviate a number of traffic-related issues for blind individuals.In this paper, we propose an intelligent guide device and interactive software to provide a more intelligent way for blind people to travel, which can effectively improve blind people’s traffic conditions and make their travel easy, convenient, and safe, reflecting society’s concern for blind people.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Influence of Taijiquan Exercise on Mentality and Emotion Regulation by Intelligent Medical Big Data Analysis

Taijiquan training emphasizes the relaxation of the mind and the body, pay attention to maintain the peace of mind, and minimize the impact of external interference on the body so as to make the mind more comfortable.This study mainly explores the influence of taijiquan practice on emotion regulation based on intelligent medical health big data analysis.The significance of taijiquan in developing and improving the positive emotions of middle‐aged people and maintaining physical and mental health is expounded.There are two methods of data collection: full collection and incremental collection.In this study, when the psychological testing equipment was launched, a full amount of historical data was collected; after the psychological testing equipment was online, the collection method was generally carried out in the way of incremental collection.The subjects exercised taijiquan three times a week, one hour each time, and the exercise content was the 24‐style taijiquan designated by the workstation.At the same time, the subjects were asked not to engage in other regular physical exercise projects in their spare time.By longitudinal tracking and comparison of the taijiquan intervention group after participating in the taijiquan exercise intervention, the differences in the state of mind and emotion regulation strategies, and 12 subjects were selected voluntarily to participate in the emotional stroop (the color words used in the classic stroop paradigm were replaced with emotional and nonemotional words written in different colors, and the subjects were still tasked with responding to colors) experimental paradigm.In this paper, the moderate‐intensity taijiquan project is selected, which is in line with the effective value threshold theory of exercise load.It studies the effects of exercise on the body shape, cardiopulmonary function, flexibility, and balance ability of the body according to the metabolism theory and the movement balance theory of the human body adapting to the environment.Before the experiment, there was no significant difference between the taijiquan training group and the control group, but after the experiment, there was a significant difference between the taijiquan training group and the control group ( p &lt;0.05).Taijiquan has a significant effect on improving students’ body shape, cardiopulmonary function, flexibility, balance, and mood.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Influence of Degree of Chinese Cultural Identity and Performance Expectation on Consumption Attitude for Health Care of Traditional Chinese Medicine

There are some advantages of traditional chinese medicine in anti-covid-19, and more and more chinese people are beginning to accept health care of traditional chinese medicine (tcm).By selecting two important independent variables, degree of chinese cultural identity and performance expectation, their influence mechanism on the consumption attitude of health care for tcm is studied.The results show that the two dimensions of degree of chinese cultural identity significantly affect the consumption attitude of health care for tcm, and the surface recognition dimension negatively affects the behavioral attitude of health care for tcm.The deep behavioral dimension has a positive impact on the consumption attitude of health care for tcm.Performance expectation has a positive impact on the consumption attitude of health care for tcm.Chinese cultural identity and performance expectation have a positive interaction on the consumption attitude of health care for tcm.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Knockdown of Long Noncoding RNA CAT104 Inhibits the Proliferation, Migration, and Invasion of Human Osteosarcoma Cells by Regulating MicroRNA-381

Osteosarcoma is the most common primary malignant bone tumor in children and adolescents.This study aimed to explore the effects of long noncoding rna cat104 and micro rna-381 (mi r-381) on osteosarcoma cell proliferation, migration, invasion, and apoptosis, as well as the underlying potential mechanism.We found that cat104 was highly expressed in osteosarcoma mg63 and os-732 cells.Knockdown of cat104 significantly inhibited os-732 cell proliferation, migration, and invasion, but promoted cell apoptosis.Cat104 regulated the expression of mi r-381, and mi r-381 participated in the effects of cat104 on os-732 cells.Zinc finger e-box-binding homeobox 1 (zeb1) was a direct target gene of mi r-381, which was involved in the regulatory roles of mi r-381 in os-732 cell proliferation, migration, invasion, and apoptosis, as well as c-jun n-terminal kinase (jnk) and wnt/β-catenin pathways.In conclusion, our research verified that suppression of cat104 exerted significant inhibitory effects on osteosarcoma cell proliferation, migration, and invasion by regulating the expression of mi r-381 and downstream zeb1, as well as jnk and wnt/β-catenin pathways.

Journal: Oncology Research (2018)
Publication types: Research Article;
MicroRNA-411 Inhibits Cervical Cancer Progression by Directly Targeting STAT3

Cervical cancer is the third most common gynecological cancer and the fourth leading cause of cancer-related deaths in women around the world.Substantial evidence has demonstrated that micro rna (mi rna) expression is disordered in many malignant tumors.The dysregulation of mi rnas has been suggested to be involved in the tumorigenesis and tumor development of cervical cancer.Therefore, identification of mi rnas and their biological roles and targets involved in tumor pathology would provide valuable insight into the diagnosis and treatment of patients with cervical cancer.Micro rna-411 (mi r-411) has been reported to play an important role in several types of human cancer.However, the expression level, role, and underlying molecular mechanisms of mi r-411 in cervical cancer remain unclear.Therefore, the objectives of this study were to investigate the expression pattern and clinical significance of mi r-411 in cervical cancer and to evaluate its role and underlying mechanisms in this disease.In this study, we confirmed that the expression of mi r-411 was significantly downregulated in both cervical cancer tissues and cell lines.Low expression of mi r-411 was associated with tumor size, figo stage, lymph node metastasis, and distant metastasis.Additionally, mi r-411 overexpression inhibited cell proliferation and invasion in cervical cancer.Furthermore, signal transducer and activator of transcription 3 (stat3) was identified as a direct target of mi r-411 in this disease.In clinical samples, mi r-411 expression levels were inversely correlated with stat3, which was significantly upregulated in cervical cancer.Restored stat3 expression abolished the tumor-suppressing effects of mi r-411 overexpression on the proliferation and invasion of cervical cancer cells.In conclusion, our data demonstrated that mi r-411 inhibited cervical cancer progression by directly targeting stat3 and may represent a novel potential therapeutic target and prognostic marker for patients with this disease.

Journal: Oncology Research (2018)
Publication types: Research Article;
Long Noncoding RNA XIST Regulates miR-137-EZH2 Axis to Promote Tumor Metastasis in Colorectal Cancer

We aimed to investigate the significant role of long noncoding rna x inactive specific transcript (xist) in regulating tumor metastasis in colorectal cancer (crc), as well as its possible mechanism.Expression of lnc rna xist in crc tissues and crc cells was detected.Crc cells were transfected with pc-xist, blank control si-xist, or si-control, and then the effects of lnc rna xist on crc cell migration and invasion were investigated, along with the interaction between lnc rna xist and mi r-137.Lnc rna xist was upregulated in crc tissues.Compared with ht29 cells that had low metastatic potential, xist was markedly more highly expressed in lo vo cells that had a higher metastatic potential.Overexpression of xist promoted the migratory and invasive potential of ht29 cells, while knockdown of xist inhibited the migratory and invasive potential of lo vo cells.Moreover, epithelial‐mesenchymal transition (emt) markers, including e-cadherin, n-cadherin, and vimentin, exhibited corresponding expression changes.In addition, mi r-137 was inhibited by xist, and inhibition of mi r-137 could reverse the effects of knockdown of xist on the migratory and invasive potential of lo vo cells.Furthermore, enhancer of zeste homolog 2 (ezh2) was confirmed as a target of mi r-137.Our data reveal that lnc rna xist may promote tumor metastasis in crc possibly through regulating the mi r-137‐ezh2 axis.Lnc rna xist may serve as a prognostic indicator for crc progression.

Journal: Oncology Research (2018)
Publication types: Research Article;
Image Processing Technology Based on Internet of Things in Intelligent Pig Breeding

In recent years, with the continuous innovation of the internet of things technology, the image processing technology in the internet of things technology has become more and more mature.Automated pig raising will become the mainstream pig raising technology, making the research of image processing technology in the intelligent pig breeding face a change.It has become more and more important.The traditional pig raising model cannot provide a suitable growth and development environment for the pigs.The pigs are disturbed by diseases and environmental discomforts during the growth process, which increases the mortality of the pig breeding process and cannot provide consumers with a guarantee.In order to solve the problem of unfavorable factors during the growth of live pigs, this article uses image processing technology to analyze data through images obtained through automated monitoring and management, uses the system to conduct intelligent, digitized, and standardized management of pig breeding data, and reports to the corresponding.The control module issues instructions to improve the corresponding environmental information and realize the intelligent management of pig breeding.This article will use image processing technology to monitor the growth of pigs in intelligent pig breeding.Studies have shown that the use of image processing technology to realize the intelligent management of pig breeding can help pig farms to carry out manual management to improve production efficiency and management efficiency.The management mode of the pig industry has changed from fuzzy to refined.The breeding cost of pig farms and a lot of manpower and material resources should be reduced, reducing the probability of pigs getting sick and the impact of the environment, reducing the mortality of pigs, improving their economic benefits, and providing consumers with a strong guarantee.

Journal: Mathematical Problems in Engineering (2021)
Publication types: Research Article;
In Vivo Growth Inhibition of Human Caucasian Prostate Adenocarcinoma in Nude Mice Induced by Amygdalin with Metabolic Enzyme Combinations

Cancer of the prostate is an indicated type that is often recorded as a kind of cancer in men and the second critical cause of mortality through cancer cases.Many pharmacological investigations have shown that numerous herbal substances possess anticancer action.Amygdalin (amd) has antitumour capabilities and works as an antioxidant, antibacterial, anti‐inflammatory, and immune‐regulating characteristics.The anticancer effects of amygdalin and its metabolizing enzymes, rhodanese (rhd) and betaglucosidase (bgd), were examined in vivo, as well as their antitumour processes.Novel, effective combination agents are necessary to increase existing cancer treatment rates.This research was aimed at determining the anticarcinogenic impact of amygdalin (amd) in vivo.This research was aimed at determining the rhd and bgd on the anticarcinogenic impact of amd in vivo.Subcutaneously, pc3 prostate cancer cell lines were implanted into nude mice.Mice were treated every day with 0.5 ml of 50 mg/ml (amd), amd+ (rhd 0.1 mg/ml), amd+(bgd 0.1 mg/ml), and doxorubicin (dox 50 mg/ml).Mice were normalized for negative control with untreated mice.In in vivo, morphopathological alterations in the tumour tissue were analyzed by histopathological staining methods.After 35 days of therapy, tumour growth and size inhibition were evident, indicating a function for the metabolic enzymes bgd and rhd in regulating amd’s anticancer effect in vivo.We concluded the critical role of metabolic enzymes bgd and rhd in elevating the antigrowth of pc3 cancer cell lines in balb/c nude mice treated with amd.

Journal: BioMed Research International (2022)
Publication types: Research Article;
IGF-1 Promotes Epithelial-Mesenchymal Transition of Lens Epithelial Cells That Is Conferred by miR-3666 Loss

The abnormal proliferation, migration, and epithelial‐mesenchymal transformation (emt) of lens epithelial cells (lecs) are the main reasons for vision loss caused by posterior capsular opacification (pco) after cataract surgery.Insulin‐like growth factor‐1 (igf‐1) was found to be associated with the pathogenesis of cataracts, but its biological role in pco is poorly understood.In the present study, igf‐1 overexpression facilitated the proliferation, migration, and emt, whereas knockdown of igf‐1 markedly suppressed the proliferation, migration, and tgf‐ β 2‐induced emt of lecs.Additionally, to evaluate valuable micro rnas (mi rnas) which target igf‐1 to modulate lec‐emt, we predicted mi r‐3666 might regulate igf‐1 by binding its 3’utr according to the bioinformatics database.Furthermore, we verified that mi r‐3666 directly targeted igf‐1 by luciferase reporter assay.By using mi r‐3666 mimics, cell proliferation, migration, and invasion were suppressed, while being enhanced by the reduction of mi r‐3666.Knockout of igf1 reverses the effect of the mi r‐3666 inhibitor on the malignant behavior of lecs.These results indicate the role of mi r‐3666/igf‐1 in lec‐emt that offers new strategies for the therapy and prevention of pco.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Identification of Apple Disease Grades Based on the Attention Mechanism of Lesion Location and Improved Data Enhancement Method

The output and quality of apples were greatly threatened by plant diseases.Identifying the types and grades of diseases in time was helpful to the management of diseases.When the disease occurs on a leaf, there was little change in the leaf except for the affected area.The traditional attention mechanism changed the weight of the network to all pixels in the image, which affected the ability of the network to extract the features of the lesion area.And the traditional method of data enhancement was easy to cause local similarity and local discontinuity of all sample features in the same disease grade.In this paper, the improved metric matrix for kernel regression (immkr) was used to reduce the influence of local similarity and local discontinuity of all sample features in the same class.Then, a new attention mechanism by fusing the lesion location based on visual features was proposed, and the attention of the model to the lesion area was strengthened.The experiments were carried out on three different diseases of apple named black rot, scab, and rust.The accuracy rate and recall rate of the new method on the combined dataset of plant village and plant doc were 91.55% and 92.06%, respectively, which was superior to existing methods.This algorithm has important reference significance for the identification and promotion of crop diseases.

Journal: Wireless Communications and Mobile Computing (2022)
Publication types: Research Article;
Hyal1 Expression in Colorectal Carcinoma Cell Migration and Invasiveness: Significance and Mechanism

To clarify the significance of hyaluronidsase 1 (hyal1) expression in colorectal carcinoma (crc) and its impact on tumor cell migration and invasiveness.Methods.Human crc cell lines sw480, hct116, and sw620 were purchased, elisa and western blot were used to detect the expression of hyal1 in cells, cck-8 assay to detect cell proliferation ability, cell scratch assay to check cell migration rate, and cell invasion was detected by the transwell assay.The correlation of hyal1 with crc cell migration and invasiveness capacities was analyzed.Result.Elisa results showed that supernatant hyal1 level was the lowest in sw480, highest in hct116, with the level in sw620 in between ( p &lt; 0.05 ).No evident difference was identified by western blot in hyal1 protein expression among the three cells ( p &gt; 0.05 ).The cell scratch assay and transwell assay showed that the migration and invasion ability of hct116 cells was higher than that of sw620 ( p &lt; 0.05 ).In vitro, hyal1 had a synergistic relationship with the invasiveness and migration capacities of crc cells ( p &lt; 0.05 ).Conclusion.Hyal1 is elevated in crc and is consistent with the invasiveness and metastasis abilities of crc cells.It is hoped that this research can provide reference for future prevention and treatment of crc.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;