syedzayyan/paper_mill_benchmark huggingface dataset:
Relatively low fluoride in drinking water increases risk of knee osteoarthritis (KOA): a population-based cross-sectional study in China.

Previous studies indicate that fluoride in drinking water has a toxic effect on cartilage and skeleton, which triggers osteoarthritis (oa) of which the most frequent is knee oa (koa).A cross-sectional study was conducted to assess the association between fluoride exposure and koa among 1128 subjects.Water fluoride (wf) and urinary fluoride (uf) were chosen as external exposure (internal exposure) of fluoride.Logistic regression analysis showed that an increased fluoride exposure was a risk factor for koa (wf: or = 1.318, 95% ci 1.162-1.495, p < 0.001; uf: or = 1.210, 95% ci 1.119-1.310, p < 0.001).After adjusting for covariates, the risk of koa in the 4th quartile (q) of wf was twice that of the 1st q (or = 2.079, 95% ci 1.448-2.986, p < 0.001).The risks of koa in the 2nd q, 3rd q and 4th q of uf were 1.6, 1.5, and 2.9 times higher than in the 1st q (or = 1.597, 95% ci 1.066-2.393, p = 0.023; or = 1.560, 95% ci 1.043-2.333, p = 0.030; or = 2.897, 95% ci 1.957-4.288, p < 0.001).The population aged < 60 exposed to the 4th q of wf (or uf) had a higher risk than the population exposed to the 1st q of wf (or uf) (orwf= 1.958, 95% ci 1.249-3.070, p = 0.003; oruf= 2.923, 95% ci 1.814-4.711, p < 0.001).With increasing uf by q, the male had a risk of koa.In conclusion, excessive fluoride dose in drinking water could increase the risk of koa.Especially, the population with aged < 60, male and obesity more likely to having koa when they exposed to same higher fluoride.

Journal: Environmental geochemistry and health (2023)
Publication types: Journal Article
A multi-modality physical phantom for mimicking tumor heterogeneity patterns in PET/CT and PET/MRI.

Hybrid imaging (e.g., positron emission tomography [pet]/computed tomography [ct], pet/magnetic resonance imaging [mri]) helps one to visualize and quantify morphological and physiological tumor characteristics in a single study.The noninvasive characterization of tumor heterogeneity is essential for grading, treatment planning, and following-up oncological patients.However, conventional (conv) image-based parameters, such as tumor diameter, tumor volume, and radiotracer activity uptake, are insufficient to describe tumor heterogeneities.Here, radiomics shows promise for a better characterization of tumors.Nevertheless, the validation of such methods demands imaging objects capable of reflecting heterogeneities in multi-modality imaging.We propose a phantom to simulate tumor heterogeneity repeatably in pet, ct, and mri.Methods the phantom consists of three 50-ml plastic tubes filled partially with acrylic spheres of s1: 1.6 mm, s2: 50%(1.6 mm)/50%(6.3 mm), or s3: 6.3-mm diameter.The spheres were fixed to the bottom of each tube by a plastic grid, yielding one sphere free homogeneous region and one heterogeneous (s1, s2, or s3) region per tube.A 3-tube phantom and its replica were filled with a fluorodeoxyglucose (18f) solution for test-retest measurements in a pet/ct siemens tptv and a pet/mr siemens biograph m mr system.A number of 42 radiomic features (10 first order and 32 texture features) were calculated for each phantom region and imaging modality.Radiomic features stability was evaluated through coefficients of variation (cov) across phantoms and scans for pet, ct, and mri.Further, the wilcoxon test was used to assess the capability of stable features to discriminate the simulated phantom regions.Results the different patterns (s1-s3) did present visible heterogeneity in all imaging modalities.However, only for ct and mri, a clear visual difference was present between the different patterns.Across all phantom regions in pet, ct, and mr images, 10, 16, and 21 features out of 42 evaluated features in total had a cov of 10% or less.In particular, conv, histogram, and gray-level run length matrix features showed high repeatability for all the phantom regions and imaging modalities.Several of repeatable texture features allowed the image-based discrimination of the different phantom regions (p < 0.05).However, depending on the feature, different pattern discrimination capabilities were found for the different imaging modalities.Conclusion the proposed phantom appears suitable for simulating heterogeneities in pet, ct, and mri.We demonstrate that it is possible to select radiomic features for the readout of the phantom.Most of these features had been shown to be relevant in previous clinical studies.

Journal: Medical physics (2022)
Publication types: Journal Article
Biogeographic consequences of shifting climate for the western massasauga (Sistrurus tergeminus).

The western massasauga (sistrurus tergeminus) is a small pit viper with an extensive geographic range, yet observations of this species are relatively rare.They persist in patchy and isolated populations, threatened by habitat destruction and fragmentation, mortality from vehicle collisions, and deliberate extermination.Changing climates may pose an additional stressor on the survival of isolated populations.Here, we evaluate historic, modern, and future geographic projections of suitable climate for s.Tergeminusto outline shifts in their potential geographic distribution and inform current and future management.We used maximum entropy modeling to build multiple models of the potential geographic distribution of s.Tergeminus.We evaluated the influence of five key decisions made during the modeling process on the resulting geographic projections of the potential distribution, allowing us to identify areas of model robustness and uncertainty.We evaluated models with the area under the receiver operating curve and true skill statistic.We retained 16 models to project both in the past and future multiple general circulation models.At the last glacial maximum, the potential geographic distribution associated with s.Tergeminusoccurrences had a stronghold in the southern part of its current range and extended further south into mexico, but by the mid-holocene, its modeled potential distribution was similar to its present-day potential distribution.Under future model projections, the potential distribution of s.Tergeminusmoves north, with the strongest northward trends predicted under a climate scenario increase of 8.5 w/m2.Some southern populations of s.Tergeminushave likely already been extirpated and will continue to be threatened by shifting availability of suitable climate, as they are already under threat from desertification of grasslands.Land use and habitat loss at the northern edge of the species range are likely to make it challenging for this species to track suitable climates northward over time.

Journal: Ecology and evolution (2022)
Publication types: Journal Article
Recent advances in diabetes treatments and their perioperative implications.

Of review the implications for perioperative management of new oral antihyperglycemic medications and new insulin treatment technologies are reviewed.Recent findings the preoperative period represents an opportunity to optimize glycemic control and potentially to reduce adverse outcomes.There is now general consensus that the optimal blood glucose target for hospitalized patients is approximately 106-180 mg/dl (6-10 mmol/l).Recommendations for the management of antihyperglycemic medications vary among national guidelines.It may not be necessary to cease all antihyperglycemic agents prior to surgery.Sodium-glucose cotransporter 2 inhibitors (sglt2i) are associated with higher rates of ketoacidosis especially in acutely unwell and postsurgical patients.The clinical practice implications of new insulin formulations, and new systems for insulin delivery, are not clear.The optimal perioperative management of these will vary depending on local institutional factors such as staff skills and existing clinical practices.Improved hospital care delivery standards, quality assurance, process improvements, consistency in clinical practice, and coordinated multidisciplinary teamwork should be a major focus for improving outcomes of perioperative patients with diabetes.Summary sulfonylureas and sglt2i should be ceased before moderate or major surgery.Other oral antihyperglycemic therapies may be continued or ceased.Complex patients and/or new therapies require specialized multidisciplinary management.

Journal: Current opinion in anaesthesiology (2019)
Publication types: Journal Article;Review
Simultaneous determination of paraquat and diquat in human plasma by HPLC-DAD: Its application in acute poisoning patients induced by these two herbicides.

Paraquat and diquat are widely used in agricultural production in many countries, which are very toxic to human beings.Paraquat can be detected in some diquat solution sold in the market.The blood concentration of paraquat or diquat is an important indicator for clinical diagnosis of paraquat or diquat poisoning.So, it is very meaningful to develop a method for simultaneous determination of paraquat and diquat in human plasma.Objective to develop and validate a hplc-dad method for simultaneous determination of paraquat and diquat in human plasma and to apply it in the acute poisoning patients by these two herbicides.Methods paraquat and diquat were simultaneously determined by hplc-dad.The plasma was treated using waters oasis®column and then separated on a thermo hypersil gold (250 × 4.6 mm, 5 μm) column with the mobile phase consisted of 75 mmol/l sodium heptane sulfonate (containing 0.1 mol/l phosphoric acid, p h 3.0) and acetonitrile (87:13, v:v) at a flow rate of 1.0 m l/min.The full-wavelength scanning was 200-400 nm, and the detection wavelength of paraquat and diquat was 257nm and 310nm, respectively.120 and 30 plasma samples from patients with paraquat and diquat poisoning were collected and analyzed by the established method.Results the standard curve for paraquat and diquat ranged from 0.05 to 20 μg/m l, and the precision of lloq for paraquat was 16.49%, which was required to be less than 20%.The precision of other concentrations was less than 14.14%.The recovery of paraquat and diquat was 95.38%-103.97% and 94.79%-98.40%, respectively.The results showed that paraquat and diquat were stable under various storage conditions.120 plasma samples of paraquat poisoning patients and 30 plasma samples of diquat poisoning patients were determined by the established method.The blood concentration of paraquat ranged from 0.10 to 20.62 μg/m l, with an average of 3.61 μg/m l, while for diquat, the concentration ranged from 0 to 26.59 μg/m l, with an average of 2.00 μg/m l.Among the diquat suspected poisoning samples, 5 samples were detected not only diquat but also paraquat, and 2 samples were detected only paraquat, no diquat.Conclusion the hplc-dad method established in this study was high throughput, high sensitivity, simple operation, and wide linear ranges.It can be used for the screening analysis and quantitative detection of paraquat and diquat in acute poisoning patients, which can provide basis for the treatment and prognosis of these two herbicides poisoning patients.

Journal: Journal of clinical laboratory analysis (2021)
Publication types: Journal Article
Blood Biochemical and Erythrocytic Morpho-pathological Consequences of Naphthalene Intoxication in Indian Teleost, Anabas testudineus (Bloch).

Anabas testudineus (bloch) was exposed to 0.71 mg/l and 1.42 mg/l (25 and 50% of lc50value respectively) naphthalene, a polycyclic aromatic hydrocarbon (pah), for 21 days.Blood biochemical parameters and erythrocytic morphological alterations were assessed to describe the naphthalene toxicity.Biochemical analysis showed a significant increase in glutamic pyruvic transaminase, gpt (576.7 ± 11.79 and 608.9 ± 12.08 u/l, respectively) and alkaline phosphatase, alp (12.9 ± 0.69 and 13.4 ± 0.64 u/l, respectively) activities under two doses compared with control.Protein and albumin (alb) content in blood decreased significantly, in comparison with control value in the tune of 22.67 ± 1.04 and 23.97 ± 1.24 g/dl, respectively and 10.7 ± 0.79 and 11.1 ± 0.67 g/dl, respectively.Erythrocytes showed varied symptomatic morphological changes under naphthalene exposure, which included severe denaturation, swelling in cells, appearance of sickle and tear drop cells, and cellular vacuolation.In particularly, the changes were more prominent under higher naphthalene exposure.Following the results, it has been able to establish that gpt, alp, protein and alb, and the morphological manifestations of erythrocytes would be good tools of biomarker in monitoring toxicological paradigm, especially to naphthalene exposure in aquatic bodies.

Journal: Environmental toxicology and pharmacology (2020)
Publication types: Journal Article
A technical note on anterolateral mobilization in vertebrobasilar dolichoectasia for relief of brainstem compression.

Vascular compression of neural tissue causing neurological symptoms is a wellknown phenomenon.This is commonly seen in trigeminal neuralgia and, less commonly, in hemifacial spasm by small arteries, which can be treated by microvascular decompression.Rarely, larger arteries, such as the vertebral arteries, may compress the brainstem.This can lead to symptoms of pontine or medullary distress like hemiparesis, dysphagia, or respiratory distress.This is treated by macrovascular decompression.Due to the rare and heterogenous nature of this disease, there is no standardized approach.We describe a novel technique whereby the vertebrobasilar system is mobilized anterolaterally towards the occipital condyle with a sling to decompress the brainstem.We report two cases of vertebrobasilar dolichoectasia causing brainstem compression.A carotid patch graft sling with anterolateral mobilization to the occipital condyle is described as a surgical nuance to macrovascular decompressive surgery.Briefly, the vertebral artery was identified and dissected away from the brainstem and the bulbar cranial nerves.Bovine pericardium graft was used to create a sling around the artery by suturing the two ends together.The sling was then fixed either to the occipital condyle using cranial plating screws or suturing to the dura of the occipital condyle.A novel surgical technique for management of vertebrobasilar dolichoectasia causing brainstem compression with progressive neurological deterioration is reported.Anatomical location and the offending vessel should guide neurosurgeons to select the best surgical option to achieve complete decompression of the involved neural structures.

Journal: Journal of cerebrovascular and endovascular neurosurgery (2022)
Publication types: Journal Article
Food choice motives among two disparate socioeconomic groups in Brazil.

Understanding the motives influencing food intake is indispensable for effective dietary recommendations aimed at promoting healthy eating in an integrative way.The objective of this study was to evaluate food choice motives across two socioeconomically different cities in brazil.A cross-sectional study with a convenience sample (n = 473) of adults living in both places was evaluated.Food choice motives were assessed by the eating motivation survey (tems) with 15 dimensions, and economic classifications were made according to the brazilian economic classification criteria (cceb).Data analysis used both a general linear model (glm) and a structural equation model (sem) adjusted for age, ethnicity, income and educational degree.Participants were mainly women (74.6%) with a mean age of 36.6 years.Cities were not invariant (δχ2 = 314.165, p < 0.001) and two distinct prediction models for food choice motives emerged.Fit indices indicate acceptable model fit for both low (cfi = 0.911; tli = 0.898; rmsea = 0.041) and high socioeconomic status groups (cfi = 0.808; tli = 0.717; rmsea = 0.081).Although cities differ in the prediction models for food choice motives, we demonstrated that there are two main networks of predictors: one related to social context predictors of food choice motives and another related to hedonic-oriented ones.Particularly, hedonic-oriented motives (i.e., pleasure) were the most relevant predictors to the group of high socioeconomic status followed by social context predictors (traditional eating and sociability).On the other hand, the group of low socioeconomic status had most of its predictors related to social context (i.e., visual appeal, traditional eating, sociability, social norms and social image) and also price, but this last one was the least important among the most important predictors.

Journal: Appetite (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Diagnostic and prognostic significance of long noncoding RNA LINC00173 in patients with melanoma.

A growing volume of literature has suggested long noncoding rnas (lnc rnas) as important players in tumor progression.In this study, we aimed to investigate the expression and prognostic value of lnc rna linc00173 (linc00173) in melanoma.Methods linc00173 expression was measured in 163 paired cancerous and noncancerous specimen samples by real-time polymerase chain reaction.The correlations between linc00173 expression with clinicopathological characteristics and prognosis were analyzed by chi-square test, log-rank test, and multivariate survival analysis.Receiver-operating characteristic curves were used for the assessment of the diagnostic value of linc00173 for melanoma patients.Results the expression level of linc00173 in melanoma specimens was distinctly higher than that in adjacent non-neoplasm specimens (p<0.01).Besides, linc00173 was expressed more frequently in patients with advanced melanoma than in patients with early melanoma.Multivariate assays confirmed that linc00173 expression level was an independent prognostic predictor of melanoma patients (p<0.05).Conclusion our data indicated that linc00173 expression could serve as an unfavorable prognostic biomarker for melanoma patients.

Journal: Revista da Associacao Medica Brasileira (1992) (2022)
Publication types: Journal Article
Diabetes-Specific Risk-Taking in Young Adulthood: A Closer Look.

Risk-taking behaviors are not a new phenomenon for young adults (yas) and are an important aspect of understanding decision-making for yas with diabetes.This article builds on a previous model of diabetes-specific risk-taking by providing other examples of risky situations and behaviors that are specific to yas with type 1 diabetes, reviewing models of risk-taking behavior, and discussing how these models might inform clinical care for yas with diabetes.

Journal: Diabetes spectrum : a publication of the American Diabetes Association (2021)
Publication types: Journal Article
Gypenoside A protects ischemia/reperfusion injuries by suppressing miR-143-3p level via the activation of AMPK/Foxo1 pathway.

Ischemia-reperfusion (i/r) injury is a major side effect associated with coronary heart disease (chd).Gypenoside a (gp) is one of the dominant active components of gynostemma pentaphyllum and has the potential to attenuate myocardial i/r injuries.The major purpose of this study was to explore the mechanism driving the protective effect of gp on myocardial tissue by focusing on the interaction between gp and mi r-143-3p.Cardiomyocytes were pre-treated with gp and subjected to oxygen-glucose deprivation/re-oxygenation (ogd/r).Changes in cell viability, apoptosis, and expression levels of factors involved in the adenosine monophosphate activated protein kinase (ampk)/foxo1-mediated mi r-143-3p pathway were detected.The levels of ampk and mi r-143-3p were then modulated using an inhibitor and a mimic, respectively, to confirm their central roles in the effect of gp.The administration of gp attenuated ogd/r-induced injuries by increasing cell viability and suppressing apoptosis, which was associated with the activation of ampk/foxo1 signaling and the decreased level of mi r-143-3p.The down-regulation of ampk and up-regulation of mi r-143-3p both counteracted the function of gp on cardiomyocytes.The role of mi r-143-3p suppression in the anti-i/r effect of gp was also verified with rat model.The injection of mi r-143-3p agomir inhibited the cardio-protective effect of gp in a manner similar to that in the in vitro assays.Our results confirm the cardio-protective effect of gp, which is exerted by suppressing the level of mi r-143-3p via the activation of ampk signaling.

Journal: BioFactors (Oxford, England) (2020)
Publication types: Journal Article
The Need for Oral Hygiene Care and Periodontal Status among Hospitalized Gastric Cancer Patients.

Poor oral hygiene leads to the accumulation of dental plaque, thus contributing to the initiation of periodontal disease (pd).Local infections can lead to systemic inflammatory responses, which are essential mediators for the evolution of systemic conditions or cancer tumorigenesis.Often, patients hospitalized with life-threatening and incapacitating disorders such as gastric cancer (gc) might lose interest in keeping their mouth healthy.This study evaluates oral hygiene, periodontal status, and the need for oral care and medical personnel to assist in achieving it in patients hospitalized with gc.This study was carried out on 25 patients with a diagnosis of gc, divided into two groups (gp-14 patients from the gastroenterology department, and sp-11 patients from the 1st department of surgery).Patients were examined on the day of admission (t0), the day of the medical procedure of endoscopy or surgery (t1), and the day of discharge (t2), recording the number of absent teeth, dental plaque (pi), bleeding on probing (bop), probing depths (ppd), frequency of toothbrushing, and if the oral hygiene had been self-performed or assisted.Data were subjected to statistical analysis.Our results showed that, in both the gp and the sp group, there were strong and statistically significant correlations between pi and bop measured on the last day of hospitalization and the period of hospitalization after the medical procedure.Longer hospital stays and the presence of surgery were risk factors for changing toothbrushing frequency.Results also highlight the need for a dentist to diagnose and eventually treat periodontal disease before and after hospitalization, and for a trained nurse who should help take care of the patient's oral hygiene during hospitalization.

Journal: Journal of personalized medicine (2022)
Publication types: Journal Article