syedzayyan/paper_mill_benchmark huggingface dataset:
Effect of Xiaoyutang Combined with Intraperitoneal Heat Perfusion Chemotherapy on Immune Function, Circulating mir, Prognosis, and Survival of Postoperative Patients with Colorectal Cancer

To explore the effects of xiaoyutang combined with intraperitoneal heat perfusion chemotherapy on immune function, circulating mir, and prognosis and survival of postoperative patients with colorectal cancer.Methods.A total of 96 patients with colorectal cancer who were treated in our hospital from may 2018 to august 2019 and followed up to august 2021 were selected as the study subjects.The patients were randomly divided into a control group and study group by a 1 : 1 random number table method, 48 cases in each group.Patients in the control group were given intraperitoneal thermal perfusion chemotherapy after surgery, and patients in the research group were treated with xiaoyutang on this basis.The treatment cycle was 21 days, and all patients were treated for 3 consecutive cycles.The therapeutic efficacy, immune function (cd3+, cd4+, and cd4+/cd8+), circulating mir (mir-29a, mir-145, and mir-92a), prognosis, and survival of the two groups were compared.Results.After 3 cycles of treatment, orr and dcr in the study group were higher than those in the control group (60.42% vs.37.50%) and 85.42% vs.66.67%, respectively, with statistical significance ( p &lt; 0.05 ).There were statistically significant differences in cd3+, cd4+, cd4+/cd8+, mir-29a, mir-145, and mir-92a time points and intergroup and intergroup interactions between the two groups ( p &lt; 0.05 ); the levels of cd3+, cd4+, and cd4+/cd8+ in the study group were higher than those in the control group after 1, 2, and 3 cycles of treatment ( p &lt; 0.05 ); the expressions of mir-29a, mir-145, and mir-92a were significantly lower than those in the control group ( p &lt; 0.05 ).By the end of follow-up, 3 cases were lost to follow-up in the study group and 5 cases in the control group.The recurrence rate and mortality of the study group were lower than those of the control group at 1- and 2-year follow-up ( p &gt; 0.05 ), and the mean survival time of patients in the study group was higher than that in the control group; the differences were statistically significant ( χ 2 = 5.151 , p = 0.023 ).Conclusion.Xiaoyutang combined with peritoneal heat perfusion chemotherapy has a good postoperative effect on patients with colorectal cancer, which can effectively improve the immune function and circulating mir of patients with colorectal cancer, reduce tumor recurrence, and improve the prognosis of patients.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Clinical Study;
Effect of Vaginoscopy versus Conventional Hysteroscopy on Pain, Complications, and Patient Satisfaction in Patients with Endometrial Polyps

Hysteroscopy is considered the gold standard for diagnosing intrauterine pathology.Traditional hysteroscopy requires the placement of a vaginal speculum and cervical forceps, which are large in diameter, causing discomfort and pain to the patient and even causing vagal reflexes.Aims.To investigate the impact and clinical value of vaginoscopy versus conventional hysteroscopy on pain, complications, and patient satisfaction in patients with endometrial polyps and to analyse the advantages of clinical application of vaginoscopy examination.Materials and methods.One hundred and twenty-five patients with endometrial polyps treated in our hospital from may 2021 to december 2021 were selected for this study and divided into 52 cases in the hysteroscopy group and 73 cases in the vaginoscopy group according to the random remainder grouping method.Conventional hysteroscopy was used, and in the vaginoscopy group, vaginoscopy was performed.The impact of pain, complications, patient satisfaction, and clinical value of the two groups was observed and compared.Results.The time taken for the examination varied between the different hysteroscopic methods, with the hysteroscopy group taking the longest time compared to the vaginoscopy group ( p &lt; 0.01 ).The vas scores immediately after the examination and 30 minutes after the examination were both significantly higher in the hysteroscopy group than in the vaginoscopy group ( p &lt; 0.01 ).The difference in npy, pge2, and 5-ht after the pain-causing mediator intervention was significantly better in the vaginoscopy group than in the hysteroscopy group.The difference in the incidence of complications such as abortion syndrome, cervical laceration, uterine perforation, and haemorrhage after treatment was significantly lower in the vaginoscopy group than in the hysteroscopy group.In the vaginoscopy group, the satisfaction rate was 91% significantly higher than that of the hysteroscopy group ( p &lt; 0.05 ).Conclusion.The vaginoscopy technique shortens the examination and treatment time, reduces patient pain, improves patient compliance, reduces the use of preintervention drugs and anaesthetics, and reduces complications.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Effect of Shenqi Fuzheng Injection on Leukopenia and T-cell Subsets in Patients with Non-small Cell Lung Cancer Undergoing Radiotherapy

The aim of this study is to evaluate the effect of shenqi fuzheng injection on leukopenia and t-cell subsets in patients with non-small cell lung cancer (nsclc) undergoing radiotherapy.Methods.A total of 124 patients with advanced nsclc treated in the oncology department of our hospital from january 2017 to january 2019 were included and assigned at a ratio of 1 : 1 to receive conventional radiotherapy (control group, n = 62) or conventional radiotherapy plus shenqi fuzheng injection (study group, n = 62) via the random number table method.Results.The study group showed a significantly higher objective response rate (orr) and a lower incidence of leukopenia versus the control group ( p &lt; 0.05 ).After the treatment, shenqi fuzheng injection resulted in significantly lower levels of carcinoembryonic antigen (cea) and neuron-specific enolase (nse) in the study group versus conventional treatment given to the control group.After the treatment, the control group showed significantly decreased ratios of cd3+ t cells, cd4+ t cells, and cd4+/cd8+, and an increased ratio of cd8+ t cells, and significant differences when compared with the study group.The t-cell subsets of the patients in the study group showed no significant changes than those between the treatment.The median os was 20.0 months in the control group and 23.5 months in the study group.The differences between the two groups in terms of os did not come up to the statistical standard.Conclusion.Shenqi fuzheng injection for nsclc patients undergoing radiotherapy elevates the number of white blood cells, regulates t-cell immune function, reduces tumor markers, and enhances clinical efficacy.Further clinical trials are, however, required prior to clinical promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Effect of Perioperative Comprehensive Nursing Intervention on Transcatheter Arterial Chemoembolization in Patients with Primary Hepatic Carcinoma

To study and analyze the effect of perioperative comprehensive nursing intervention on transcatheter arterial chemoembolization (tace) in patients with primary hepatic carcinoma (phc).Methods.One hundred and ten patients with phc diagnosed in our hospital from may 2019 to january 2022 were randomly selected and divided into a control group (n = 55) and an observation group (n = 55) by random number sorting according to odd and even numbers.Patients in the control group received conventional nursing interventions and those in the observation group received comprehensive nursing interventions.The two groups were compared in terms of surgical status, quality of life (qo l), and nursing satisfaction.Results.The operation time, postoperative bed rest time, and hospital stay in the observation group were significantly ( p &lt; 0.05 ) shorter than those in the control group; the observation group had significantly ( p &lt; 0.05 ) higher scores of quality of life, including somatic function, emotional function, role function, social function, and cognitive function than the control group; chemotherapy adverse reactions including fever, abdominal pain, urinary retention, and gastrointestinal reactions in the observation group were significantly less than those in the control group ( p &lt; 0.05 ); the total incidence of complications in the observation group was significantly ( p &lt; 0.05 ) lower than that in the control group.The total satisfaction with nursing care in the observation group was significantly ( p &lt; 0.05 ) higher than that in the control group.Conclusion.The perioperative application of comprehensive nursing intervention in tace for patients with phc aids in the smooth operation, improves patients’ qo l, lowers the risk of chemotherapy reactions and complications, and enhances patient satisfaction and nursing quality.These advantages justify a wider perioperative application of comprehensive nursing intervention in tace clinical practice.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Effect of Orthodontic Treatment on Anterior Tooth Displacement in Patients with Periodontal Disease: A Meta-Analysis

To systematically evaluate the effect of orthodontic treatment (odt) on anterior tooth displacement (atd) in patients with periodontal disease.Methods.Pub med, web of science, embase, china national knowledge infrastructure, and wanfang databases were electronically searched for relevant literature studies on odt and basic treatment for atd in patients with periodontal disease, and then the related journals and reference lists of the included studies were manually searched.The search time was set from january 2010 to may 2021.Stata 16.0 software was used for meta-analysis.Results.Totally, 783 articles were retrieved, and finally, 14 studies were included.The effective rate of basic treatment combined with otd was significantly higher than that of basic treatment alone (or = 7.27, 95% ci: 3.76, 14.04).Specifically, the combined treatment led to lower values of periodontal pocket depth (smd = −2.30, 95% ci: −2.94, −1.66), anterior overjet (smd = −2.75, 95% ci: −3.72, −1.78), anterior overbite (smd = −2.13, 95% ci: −3.16, −1.10), and periodontal bleeding index (smd = −4.25, 95% ci: −5.48, −3.03) compared with those of basic treatment alone.Conclusion.Compared with basic treatment, odt combined with basic treatment is more effective for patients with periodontal disease-caused atd and can also improve the clinical symptoms of patients.

Journal: Journal of Healthcare Engineering (2021)
Publication types: Meta-Analysis;
Effect of Operation Room Nursing Intervention and Ceramic Prosthesis on Total Hip Arthroplasty

In order to solve the problems of large trauma, many postoperative complications, and complex operation of artificial hip arthroplasty, a method to analyze the application effect of operating room nursing intervention in artificial hip arthroplasty was proposed.Firstly, 120 patients who underwent hip arthroplasty in our hospital from january to december 2017 were selected; secondly, they were randomly divided into routine group (60 cases) and intervention group (60 cases); finally, on this basis, the intervention group strengthened the nursing in the operating room and used nanoceramic prosthesis.The harris score of hip joint, the incidence of postoperative complications, and the satisfaction with nursing services were compared between the two groups.The results showed that the harris score of hip joint and the satisfaction score of nursing service in the intervention group were significantly higher than those in the routine group ( p &lt; 0.05 ); the incidence of postoperative complications in the intervention group was significantly lower than that in the routine group ( p &lt; 0.05 ).It is proved that actively carrying out nursing intervention in the operating room and using nanoceramic prosthesis can not only improve the clinical efficacy and nursing service satisfaction of patients undergoing total hip arthroplasty but also reduce the incidence of complications.

Journal: Scanning (2022)
Publication types: Clinical Study;
Effect of nHA-Coated Femoral Stem Prosthesis Combined with Platelet-Rich Plasma in Hemi Hip Replacement of Femoral Neck Fracture in the Elderly

This study investigated the efficacy of nanohydroxyapatite- (n ha-) coated biological prosthesis combined with platelet-rich plasma (prp) in hemi hip replacement of femoral neck fracture (fnf) in the elderly.Methods.From september 2018 to september 2021, 102 elderly patients with fnf treated in our hospital were chosen and divided into two groups according to different intervention methods.Fifty-one patients in the bone cement group were treated with bone cement prosthesis, and the rest 51 patients in the observation group were treated with n ha biological prosthesis combined with prp in hemi hip replacement.In order to explore the osteogenic effect of n ha and prp, osteoblasts were cultured.Results.It was found that n ha and prp could both effectively promote the proliferation of osteoblasts and improve their mineralization ability, especially when used in combination.In the course of clinical therapy, we found that the use of biological prosthesis combined with prp could effectively reduce the level of serum procollagen type i carboxy terminal peptide (picp) and better improve the levels of bone alkaline phosphatase (balp) and bone gla protein (bgp), so as to reduce the bone conversion rate and promote the formation of new bone around the prosthesis.In addition, no significant difference was found in intraoperative bleeding, operation time, hospital stay, 48 h drainage volume, partial weight-bearing time, and complete weight-bearing time between two groups.Otherwise, the use of biological prosthesis could effectively avoid the occurrence of adverse reactions such as bone cement crisis and fracture around femoral prosthesis, so as to better restore the hip function and improve patients’ life quality.Conclusions.Therefore, in hemi hip replacement of fnf in the elderly, n ha biological prosthesis combined with prp can effectively promote the formation of new bone around the prosthesis stem, so as to obtain good initial stability, enable patients to carry out early weight-bearing exercise, and effectively avoid adverse reactions caused by bone cement prosthesis, thus improving patients’ hip function and life quality.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Effect of Mobile Internet Technology in Health Management of Heart Failure Patients Guiding Cardiac Rehabilitation

In this paper, we are going to explore the effect of mobile internet technology in health management for the heart failure patients with cardiac rehabilitation.To implement and evaluate its effects in real environment, a total of 60 heart failure patients were divided, preferably in random fashion, into two groups of 30 cases, i.e., control and observation groups.The former group has received the routine home cardiac rehabilitation after discharge, and the latter group, i.e., observation, has received home cardiac rehabilitation based on mobile medical technical guidance after discharge.The 6 min walking test, minnesota cardiac dysfunction quality of life scale score, cardiac function index, and cardiac rehabilitation training compliance were matched between these groups specifically before and after the intervention.After 12 weeks of intervention, the 6 min walking test, minnesota cardiac dysfunction quality of life scale score, b-type natriuretic peptide of n-terminal, end-diastolic diameter preferably left ventricular, left ventricular ejection fraction, and compliance of training, specifically in the observation group, were better than the control group whereas statistically significant differences were observed, i.e., p &lt; 0.01 .Home cardiac rehabilitation guided by mobile internet technology can improve the function of cardiac, exercise tolerance, life’s quality, and compliance of patients with heart failure.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Effect of Intensive Psychological Care on Patients with Benign Breast Lumps after Mammotome-Assisted Tumor Resection

The aim of the study was to evaluate the effect of intensive psychological care on patients with benign breast lumps after mammotome-assisted tumor resection.Methods.A total of 160 patients with benign breast lumps diagnosed and treated in our hospital between may 2019 and january 2021 were recruited and divided into a study group (n = 80) and a control group (n = 80) via the random number table method.All patients received mammotome-assisted tumor resection.Patients in the control group received conventional nursing, and those in the study group received intensive psychological care.The outcome measure included quality of life of patients, psychological states, treatment compliance, and nursing satisfaction.Results.The differences in the functional assessment of cancer therapy-general (fact-g) scores, self-rating anxiety scale (sas) scores, hamilton depression rating scale (hamd) scores, and morisky scores between the two groups were not significant before the intervention ( p &gt; 0.05 ).The fact-g scores improved in both groups after the intervention, with higher results in the study group than those in the control group ( p &lt; 0.05 ).Patients in the study group showed a significantly greater reduction in the sas and hamd scores than those in the control group ( p &lt; 0.05 ).Intensive psychological care used in the study group resulted in significantly higher compliance scores in the body mass control, medication compliance, exercise compliance, and dietary compliance versus conventional care for the control group ( p &lt; 0.05 ).Conclusion.Intensive psychological care provides satisfactory outcomes in patients with benign breast lumps after mammotome-assisted tumor resection.It effectively improves the quality of life of patients, relieves their negative emotions, and strengthens treatment compliance and patient satisfaction, which shows good potential for clinical promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Effect of Integrated Psychobehavioral Care on Emotional-Behavioral Responses, Cognitive Changes in Outpatients with Schizophrenia Followed Up: Based on a Prospective Randomized Controlled Study

In recent years, influenced by the continuous improvement and development of the medical service model and the increasing demands of modern people for the quality of clinical care, the clinical treatment of schizophrenic groups has also received widespread attention and importance from all sectors of society.Psychobehavioral care is administered to patients during active antipsychotic treatment, which can maximize the patient’s cooperation with clinical work and thus play an auxiliary role in treatment.Aims.To investigate the impact of emotional-behavioral responses, cognitive changes in outpatient follow-up of schizophrenic patients with integrated psychobehavioral care.Materials and methods.One hundred cases of schizophrenia patients with outpatient follow-up in our hospital from march 2017 to march 2019 were selected as prospective study subjects and divided into a comparison group and an observation group of 50 cases each according to a random number table.Among them, the comparison group implemented conventional psychobehavioral care, and the observation group implemented integrated psychobehavioral care.The differences in compliance behavior, negative emotions, cognitive behavioral changes, and pain scores before and after care of schizophrenia patients in the outpatient follow-up were compared between the two groups.Results.After care, the compliance behavior, negative emotions, cognitive behavioral changes, and pain scores of schizophrenia patients in both groups with outpatient follow-up were significantly improved and significantly higher in the observation group than in the comparison group, and statistics showed that this difference was statistically significant ( p &lt; 0.05 ).conclusion.Integrated psychobehavioral care combined with conventional psychobehavioral care can effectively enhance the compliance behavior of outpatient follow-up schizophrenia patients, improve the negative emotions and pain of patients, and facilitate the active treatment of patients to improve their prognosis.It has some reference value for outpatient follow-up schizophrenia patient care.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Effect of Hospital-Family Rehabilitation Intervention on Walking Function and Lower Limb Surface Electromyography in Children with Cerebral Palsy

To explore the effect of hospital-family rehabilitation intervention on walking function and lower limb surface electromyography in children with cerebral palsy (cp).Methods.About 100 children with cp treated in our hospital from february 2019 to april 2021 were enrolled.The patients were randomly assigned into control group and study group.The control group received routine intervention, and the study group received hospital-family rehabilitation intervention.The intervention effect, gmfm88 scale score, immg value, cr value, lower limb surface emg value, and compliance of gastrocnemius muscle and tibialis anterior muscle were compared.Results.First of all, we compared the intervention effects.In the study group, 43 cases were markedly effective, 5 cases were effective, 1 case was improved, 1 case was ineffective, and the effective rate was 98.00%.In the control group, 22 cases were markedly effective, 14 cases were effective, 7 cases were improved, 7 cases were ineffective, and the effective rate of 86.00%.The intervention effect of the study group was better compared to the control group ( p &lt; 0.05 ).Secondly, we compared the scores of the gmfm88 scale.The scores of d area and e area and total score of the study group were higher compared to the control group ( p &lt; 0.05 ).The iemg values of gastrocnemius muscle and tibialis anterior muscle were compared, and the immg values of passive and active gastrocnemius muscle and tibialis anterior muscle in the study group were higher compared to the control group ( p &lt; 0.05 ).There exhibited no significant difference in cr value before intervention ( p &gt; 0.05 ).After intervention, the cr values of gastrocnemius muscle and tibialis anterior muscle in the study group were significantly lower compared to the control group ( p &lt; 0.05 ).In terms of the surface emg of lower limbs, the emg value of passive activity (gastrocnemius muscle, tibialis anterior muscle) in the study group was higher compared to the control group, and the emg value of active activity was significantly lower compared to the control group ( p &lt; 0.05 ).Finally, we compared the compliance.In the study group, there were 43 cases of complete compliance, 7 cases of compliance, and 0 cases of noncompliance, with a compliance rate of 100.00%.In the control group, there were 32 cases of complete compliance, 11 cases of compliance, and 7 cases of noncompliance with a compliance rate of 86.00%.The compliance rate of the study group was better compared to the control group ( p &lt; 0.05 ).Conclusion.The intervention of hospital-family rehabilitation model is helpful to improve the self-care ability, cognitive function, and daily activities of children with cp, enhance the walking function and lower limb surface electromyography of children with scp, and strengthen their qualities of life.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;