syedzayyan/paper_mill_benchmark huggingface dataset:
Intelligent Analysis of Exercise Health Big Data Based on Deep Convolutional Neural Network.

In this paper, the algorithm of the deep convolutional neural network is used to conduct in-depth research and analysis of sports health big data, and an intelligent analysis system is designed for the practical process.A convolutional neural network is one of the most popular methods of deep learning today.The convolutional neural network has the feature of local perception, which allows a complete image to be divided into several small parts, by learning the characteristic features of each local part and then merging the local information at the high level to get the full representation information.In this paper, we first apply a convolutional neural network for four classifications of brainwave data and analyze the accuracy and recall of the model.The model is then further optimized to improve its accuracy and is compared with other models to confirm its effectiveness.A demonstration platform of emotional fatigue detection with multimodal data feature fusion was established to realize data acquisition, emotional fatigue detection, and emotion feedback functions.The emotional fatigue detection platform was tested to verify that the proposed model can be used for time-series data feature learning.According to the platform requirement analysis and detailed functional design, the development of each functional module of the platform was completed and system testing was conducted.The big data platform constructed in this study can meet the basic needs of health monitoring for data analysis, which is conducive to the formation of a good situation of orderly and effective interaction among multiple subjects, thus improving the information service level of health monitoring and promoting comprehensive health development.

Journal: Computational intelligence and neuroscience (2022)
Publication types: Journal Article
Prescription opioid misuse among middle-aged and older adults in the United States, 2015-2016.

Adults ≥50 years of age have high rates of prescription opioid use.The purpose of this study is to estimate the prevalence and correlates of prescription opioid misuse among middle-aged and older adults in the united states who use prescription opioids.Data from adults age ≥ 50 from the two most recent cohorts (2015 and 2016) of the national survey of drug use and health were examined (n = 17,608).Characteristics of past-year prescription opioid misusers, including demographics, substance use, depression, chronic disease, and emergency department (ed) use, were compared to adults who used prescription opioids as prescribed in the past year and non-users.We used multivariable logistic regression to determine correlates of prescription opioid misuse among adults who used prescription opioids.Among the entire sample, 61.4% reported no past-year prescription opioid use, 36.0% reported past-year prescription opioid use without misuse, and 2.5% reported past-year prescription opioid misuse.Among past-year prescription opioid users, 6.6% reported misuse.Past-year misuse was higher among males, adults age 50-64, misusers of prescription sedatives, stimulants, and tranquilizers, users of other substances (i.e., tobacco, marijuana, cocaine), and those with alcohol use disorder.Past-year misuse was lower among adults with 2 or more chronic diseases.Past-year prescription misuse of sedatives (aor 4.08 [95% ci 2.05-8.12]), stimulants (aor 3.88 [95% ci 2.00-7.53]), and tranquilizers (aor 10.02 [95% ci 6.48-15.50]) were all associated with past-year opioid misuse.Characteristics of opioid misusers determined in this study-particularly misuse of other substances-may help determine middle-aged and older adults at risk for prescription opioid misuse.

Journal: Preventive medicine (2019)
Publication types: Comparative Study;Journal Article;Research Support, N.I.H., Extramural
Real-world outcomes with ipilimumab and nivolumab in advanced melanoma: a multicentre retrospective study.

To assess efficacy and toxicity of combination immunotherapy with ipilimumab plus nivolumab in routine practice in a retrospective multicentre cohort of patients with advanced melanoma.Patients and methods this retrospective analysis included patients with advanced melanoma treated with ipilimumab and nivolumab between october 2015 and january 2020 at six centres in australia, europe and the united states of america.We describe efficacy outcomes (overall survival [os], progression-free survival [pfs] and objective response rate [orr]) in treatment-naïve and pre-treated patients, with and without brain metastases, plus treatment-related adverse events (tr aes) in all patients treated.Results a total of 697 patients were identified; 472 were treatment-naïve of which 138 (29.2%) had brain metastases, and 225 were previously treated of which 102 (45.3%) had brain metastases.At baseline, 32.3% had stage m1c and 34.4% stage m1d disease.Lactate dehydrogenase was high in 280 patients (40.2%).With a median follow-up of 25.9 months, median os in the 334 treatment-naïve patients without brain metastases was 53.7 months (95% confidence interval [ci] 40.8-nr) and 38.7 months (95% ci 18.6-nr) for the 138 treatment-naïve patients with brain metastases.For the entire cohort the orr was 48%, for treatment-naïve patients without brain metastases orr was 56.6% with a median pfs of was 13.7 months (95% ci 9.6-26.5).Median pfs was 7.9 months (95% ci 5.8-10.4) and os 38 months (95% ci 31-nr) for the entire cohort.Grade 3-4 tr ae were reported in 44% of patients, and 4 (0.7%) treatment-related deaths (1 pneumonitis, 2 myocarditis and 1 colitis) were recorded.Conclusion the outcome and toxicity of combination immunotherapy with ipilimumab and nivolumab in a real-world patient population are similar to those reported in pivotal trials.

Journal: European journal of cancer (Oxford, England : 1990) (2022)
Publication types: Multicenter Study;Journal Article
Sprint Kayaking Performance Enhancement by Isometric Strength Training Inclusion: A Randomized Controlled Trial.

Performing isometric strength training (ist) can enhance various sports performance.This study compared the effects of including ist on sprint kayaking performance as compared to traditional strength training.Twenty sprint kayaking athletes (age 22 ± 4 year, stature 1.71 ± 0.09 m, body mass 72.0 ± 11.4 kg) performed a 200-m kayak ergometer time trial (200m tt), isometric squat (iso sq t), isometric bench press (iso press) and isometric prone bench pull (iso pull) during the pre- and post-tests.Athletes were randomly assigned to either traditional strength training (trad) or ist group.Both groups performed a similar strength training program twice a week for six weeks.However, half the volume for squat, bench press and prone bench pull were replaced by iso sq t, iso press and iso pull, respectively, for the ist group.Iso sq t was performed at 90° knee angle, while iso press and iso pull were performed at 90° and 120° elbow angles, respectively.Each isometric contraction was performed with maximum intensity and sustained for three seconds.A significant main time effect was observed for 200m tt (p< 0.001, ƞ2p= 0.68) and all isometric strength measures (p= 0.001-0.032, ƞ2p= 0.24-0.76) except rate of force development at 0-90 ms (rfd90) obtained from iso sq t120 and iso press90.A group main effect was observed in rfd90 obtained from iso sq t120 and iso pull120 (p= 0.003-0.004, ƞ2p= 0.37-0.39).Time x group interaction was observed for 200m tt (p= 0.027, ƞ2p= 0.68), peak force obtained from iso sq t90, iso press90, and iso pull120 (p= 0.004-0.006, ƞ2p= 0.36-0.38) and rfd90 obtained from iso sq t120 and iso pull120 (p= 0.012-0.015, ƞ2p= 0.28-0.30).Inclusion of ist resulted in greater improvement for sprint kayaking and strength performances then trad alone.

Journal: Sports (Basel, Switzerland) (2021)
Publication types: Journal Article
Family Support Practices to Impact Stress Scores in Parents of Critically Ill Children.

When a child becomes critically ill and hospitalized in intensive care, this can be emotionally and physically traumatic for parents.Objective the purpose of the initiative was to utilize a stress screening tool to quantify parental stress and examine the use of family support services as a way to impact stress scores.Methods the family stress thermometer (fst) was introduced and parents were asked to circle their stress level at up to three time points.Along with recorded stress scores, resources accessed were documented, how often it was utilized, and parental suggestions that might ease stressors recorded.Results the results indicate the fst accurately recorded elevated stress levels in parents with critically ill children, analysis showed a statistically significant decrease in the stress levels of parents over time.Conclusions this project appears to validate parental distress levels as a modifiable risk factor.Implications for nursing the fst was cost-effective and easy to administer.As part of comprehensive plans of care for families, interprofessional teams can work to design support services that meet individualized needs of parents with critically ill children.Partnering with parents to quantify their stress and responding to their needs will insure the likelihood of this happening.

Journal: Journal of doctoral nursing practice (2021)
Publication types: Journal Article
An End-User's Personal Perspective on the Need of Consumer Involvement in Research.

There is growing understanding that the consumer's voice in research needs to be stronger.Translational research studies need consumer inclusion in order to be effectively implemented.This narrative article provides the perspective of a veteran with spinal cord injury (sci) who is an active member of several study teams and serves as a consumer advocate, providing the voice of the person with sci.Factors that drive people to develop new research ideas are considered.Consumer involvement offers helpful insight into project outcomes that are valuable to the end-user.It is also recognized that data can be interpreted in several different ways depending on the observer.Including the consumer in a research project enables another interpretation, creating a more complete evaluation.Participating in health research is becoming a new standard for persons with many different illnesses and diseases.Greater things are accomplished by physicians, healthcare scientists, engineers, and healthcare consumers interacting together to increase both the quality of research projects and the quality of life for everyone involved, especially the person with the disorder.There will be more acceptance of ideas or projects when consumers are involved from the early steps and learn how the process works from beginning to end.

Journal: Journal of general internal medicine (2022)
Publication types: Journal Article
Genomic insights into the adaptation and evolution of the nautilus, an ancient but evolving "living fossil".

The nautilus, commonly known as a "living fossil," is endangered and may be at risk of extinction.The lack of genomic information hinders a thorough understanding of its biology and evolution, which can shed light on the conservation of this endangered species.Here, we report the first high-quality chromosome-level genome assembly of nautilus pompilius.The assembled genome size comprised 785.15 mb.Comparative genomic analyses indicated that transposable elements (tes) and large-scale genome reorganizations may have driven lineage-specific evolution in the cephalopods.Remarkably, evolving conserved genes and recent te insertion activities were identified in n.Pompilius, and we speculate that these findings reflect the strong adaptability and long-term survival of the nautilus.We also identified gene families that are potentially responsible for specific adaptation and evolution events.Our study provides unprecedented insights into the specialized biology and evolution of n.Pompilius, and the results serve as an important resource for future conservation genomics of the nautilus and closely related species.

Journal: Molecular ecology resources (2022)
Publication types: Journal Article
Correction of coupling error in contact-type ultrasonic evaluation of bolt axial stress.

The stress monitoring of bolted connections is crucial in the evaluation of mechanical systems' structural health, and the ultrasonic method using tof (time of flight) is considered promising in this application.However, the discrete nature of couplant layer characteristics can deteriorate the robustness of the ultrasonic method significantly.Here, for the purpose of deducting the coupling error, a compensating method of tof is proposed.In this method, the components of the waves backscattering from bolt bearing surface within the temporal signal are filtered and utilized.The analytical coupling error correction model is established and the influences of the installation eccentricity upon the model are analyzed.Meanwhile, the proposed method is further verified by a finite element simulation and the results are consistent with the analytical derivations.Ultimately, the proposed method is experimentally validated and the scattering components are extracted from the pulse echo signal by using the synchrosqueezed wavelet transform.The results imply that, after being compensated by the proposed method, the stress measurement error decreased from 5% to 1%.This research provides a novel perspective in reducing the coupling error in a concise manner and is potential in improving the practicality of the ultrasonic bolt axial stress measurement methods.

Journal: Ultrasonics (2022)
Publication types: Journal Article
Polyamidoamine dendrimer-conjugated triamcinolone acetonide attenuates nerve injury-induced spinal cord microglia activation and mechanical allodynia.

Accumulating evidence on the causal role of spinal cord microglia activation in the development of neuropathic pain after peripheral nerve injury suggests that microglial activation inhibitors might be useful analgesics for neuropathic pain.Studies also have shown that polyamidoamine dendrimer may function as a drug delivery vehicle to microglia in the central nervous system.In this regard, we developed polyamidoamine dendrimer-conjugated triamcinolone acetonide, a previously identified microglial activation inhibitor, and tested its analgesic efficacy in a mouse peripheral nerve injury model.Result polyamidoamine dendrimer was delivered selectively to spinal cord microglia upon intrathecal administration.Dendrimer-conjugated triamcinolone acetonide inhibited lipoteichoic acid-induced proinflammatory gene expression in primary glial cells.In addition, dendrimer-conjugated triamcinolone acetonide administration (intrathecal) inhibited peripheral nerve injury-induced spinal cord microglial activation and the expression of pain-related genes in the spinal cord, including nox2, il-1β, tnf-α, and il-6.Dendrimer-conjugated triamcinolone acetonide administration right after nerve injury almost completely reversed peripheral nerve injury-induced mechanical allodynia for up to three days.Meanwhile, dendrimer-conjugated triamcinolone acetonide administration 1.5 days post injury significantly attenuated mechanical allodynia.Conclusion our data demonstrate that dendrimer-conjugated triamcinolone acetonide inhibits spinal cord microglia activation and attenuates neuropathic pain after peripheral nerve injury, which has therapeutic implications for the treatment of neuropathic pain.

Journal: Molecular pain (2017)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The Association between Metabolic Syndrome and Related Factors among the Community-Dwelling Indigenous Population in Taiwan.

The aim of this study was to conduct a community-based study with a view to construct a detailed analysis about metabolic syndrome and the related risk factors of the indigenous population.This was an observational, population-based and cross-sectional study that was conducted in remote villages of an indigenous community in northern taiwan between 2010 and 2013.A total of 586 participants, 275 men and 311 women, were eligible for analysis.The participants underwent a questionnaire survey that included demographic and health behavior issues.An anthropometric assessment and measurements of blood pressure were carried out including serum biochemical variables.Metabolic syndrome (met s) was defined by following the criteria provided by the modified adult treatment panel iii (atp iii) criteria of the national cholesterol education program (ncep).Univariate and multiple logistic regressions were used to identify the risk factors for metabolic syndrome.The standardized prevalence rates of substance use (cigarette smoking, alcohol drinking and betel nut chewing) were significantly higher than the general population regardless of whether it was northern, central or southern taiwan and this was especially the case with betel nut chewing in women.The prevalence rate of metabolic syndrome was 42.9% in the indigenous population with 41.3% in men and 44.4% in women, which was higher than for urban taiwanese.In the multiple logistic regression models, we found that the significant associated factors for metabolic syndrome were older age, lower education level, high levels of uric acid, alanine transaminase (alt), gamma-glutamyl transferase (γ-gt) and creatinine.A higher prevalence rate of metabolic syndrome and substance use were observed in the indigenous population compared with urban taiwanese, especially in women.

Journal: International journal of environmental research and public health (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Three-Dimensional Honeycomb-Like Cu0.81Co2.19O4Nanosheet Arrays Supported by Ni Foam and Their High Efficiency as Oxygen Evolution Electrodes.

We prepare three-dimensional honeycomb-like cu0.81co2.19o4nanosheet arrays supported by ni foam via electrochemical codeposition of cobalt and copper hydroxides on ni foam followed by thermal oxidation.The codeposition with cu changes the morphology of the cobalt hydroxide deposit to form honeycomb-like nanostructures, significantly decreasing the onset potential for oxygen evolution.The cu0.81co2.19o4anode displays an exceptionally low overpotential of 290 m v at a current density of 10 m a cm-2in 1 m koh, and an anion-exchange membrane water electrolysis cell employing the above anode achieves a current density of 100 m a cm-2at 1.68 v in 0.1 m koh.

Journal: ACS applied materials & interfaces (2018)
Publication types: Journal Article
High Levels of Circulating Monocytic Myeloid-Derived Suppressive-Like Cells Are Associated With the Primary Resistance to Immune Checkpoint Inhibitors in Advanced Non-Small Cell Lung Cancer: An Exploratory Analysis.

Immunotherapy has become the standard of care for non-small cell lung cancer (nsclc) patients.Some patients experience primary resistance to immunotherapy.Currently, we lack a marker of resistance to immunotherapy.Myeloid-derived suppressive-like cells (mdscs) can reduce tumor response rate and survival outcomes.Methods this is an exploratory prospective observational study on metastatic nsclc patients starting immunotherapy.Baseline peripheral blood samples were collected.Monocytic (m)-mdscs were analyzed by flow cytometry.The main clinical outcomes were tumor response, progression-free survival (pfs), and overall survival (os).The association between mdsc levels and tumor response was assessed.The association of pfs with os was investigated using the kaplan-meier method and the cox proportional hazards model.Results twenty-two patients were included.The median m-mdsc value was higher in patients with progressive disease than patients with stable disease or partial response, p = 0.045.The median mdsc value in the overall population was 1.9.We found worse pfs (hr = 2.51; p = 0.046) and os (hr = 2.68; p = 0.042) in patients with m-mdsc values higher than the median.Conclusions in this exploratory analysis, high m-mdsc levels are strongly associated with primary resistance to immunotherapy.If validated in larger studies, mdsc levels in blood samples could help to select nsclc patients for higher benefit from immunotherapy.

Journal: Frontiers in immunology (2022)
Publication types: Journal Article;Observational Study
Reactive transport modelling of an intra-basalt sandstone reservoir, Rosebank, UK.

The rosebank field, located in the faroe-shetland basin, contains producible hydrocarbons in intra-basaltic siliciclastic reservoirs.The volcanic-reservoir interface is poorly studied and the geochemical system, as a function of distance from the basalt, is largely unknown.The current paper applies a geochemical model coupling mineral dissolution and precipitation with element diffusion to investigate the geochemical system in time and space from the basalt-sandstone interface.Earlier studies indicate few negative effects on reservoir properties despite the proximity to a reactive volcanic lithology.The causes of this minimal impact have not been studied.The numerical simulations in this study expand on the knowledge demonstrating that precipitation of authigenic phases at the basalt-sandstone interface buffer the formation water solution for key elements, which hamper the transport of solutes and subsequent precipitation of secondary minerals within the reservoir.Saturation index values over the simulated period indicate that precipitation of authigenic phases should not extend beyond the basalt-sandstone interface.This shows that diffusion alone is not enough to reduce the reservoir quality due to increased precipitation of secondary phases.The basalt dissolution rate varies according to the silica concentration.The combined effects on silica concentration by diffusional fluxes, mineral precipitation and dissolution, control the basalt dissolution rate, and there are no differences in the results between high and low basalt reactive surface area.

Journal: Scientific reports (2021)
Publication types: Journal Article
Potential Value of the Insights and Lived Experiences of Addiction Researchers With Addiction.

People in remission from substance use disorders (suds) have a history of using their own experience (also referred to as "experiential knowledge" or "expertise") to support those in or seeking sud remission.In recent years, people with this experiential knowledge are being incorporated into research protocols to better guide research questions and inform the real-world uptake of sud treatments and recovery supports.In these research contexts, however, those with research expertise and addiction rarely speak freely about these overlapping perspectives.The aim of this commentary is to increase awareness regarding the existence of this group (addiction researchers with addiction) and to explore the possibility that their expertise may help advance addiction science while helping to reduce stigma.

Journal: Journal of addiction medicine (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, N.I.H., Intramural;Research Support, U.S. Gov't, Non-P.H.S.