syedzayyan/paper_mill_benchmark huggingface dataset:
The Effect of Exercise Training on the Detection of Heart Rate and Body Temperature Sensors in Adolescents

The aim of this study is to study the effect of exercise training on heart rate and body temperature sensor detection in adolescents.For the methods of logical analysis, test, and mathematical statistics, this paper takes 60 students aged 13-15 in the experimental middle school as the research subjects to explore the characteristics of heart rate changes of middle school students under different high-intensity intermittent exercise schemes.Then, it analyzes the characteristics of heart rate change in exercise center and heart rate change in high-intensity intermittent exercise.The experimental results show that the high-intensity intermittent exercise of adolescents aged 13-15 presents the stage of rapid recovery and buffer recovery.Whether in the quiet heart rate buffer stage or the rapid heart rate increase stage, as well as the “extreme heart rate maintenance stage” and heart rate recovery stage, the heart rate change point of 15-year-old adolescents is 1-3 seconds later than that of 13-year-old and 14-year-old adolescents.In addition, in the heart rate maintenance stage of 15-year-old adolescents, the heart rate fluctuates greatly.The rapid recovery stage of boys is 1 minute, and the heart rate can reach the quiet heart rate after 4-5 minutes.The rapid recovery stage of girls is 1.5 minutes, and the heart rate can reach the quiet heart rate after 4-5 minutes.The older the age of high-intensity intermittent training of adolescents aged 13-15, the longer the rapid rise stage of heart rate change, and there was no significant change in quiet heart rate buffer stage and body temperature.

Journal: Journal of Sensors (2022)
Publication types: Research Article;
Delayed Surgery to Preserve Kidney with Grade IV Injury

Since the introduction of the alara (“as low as reasonably achievable”) concept, the management of severe renal trauma has shifted.Our hospital promotes delayed surgical intervention for grade iv closed renal injury, to preserve renal function.In this study, we retrospectively reviewed the management and outcomes of patients with grade iv closed renal injury in our hospital.Objective.To evaluate the management and outcome of grade iv closed renal injury.Methods.We retrospectively reviewed the medical records of 45 patients with grade iv closed renal injury; namely, 36 men and 9 women with an average age of 35.6 years.All patients were diagnosed with grade iv closed renal injury in accordance with the guidelines of the american association for the surgery of trauma.All hemodynamically-stable patients with renal trauma were treated conservatively for approximately 13 days and then underwent surgery only to clear the perirenal hematoma and not to repair or resect the affected kidney.Abstracted data included patient demographics, mechanism of injury, admission hemodynamics, ct findings, and mortality.The primary outcome was the success rate of nonsurgical treatment, and the secondary outcome was the complication of nonsurgical treatment.Results.All patients responded and were discharged, and no patients died.We followed 35 (77.8%) patients for at least 1 year.One patient with partially devitalized renal parenchyma underwent surgery to remove the affected kidney.Eleven patients (31.4%) suffered complications, namely, three (8.6%) cases of hypertension, four (11.4%) cases of hematuria, two cases (5.7%) of urinary tract infection, and two (5.7%) cases of urinoma.Conclusions.Delayed exploratory surgery only to remove the hematoma should be considered in hemodynamically-stable patients with grade iv closed renal injury.This approach can avoid high nephrectomy rates associated with emergency surgery and reduce the complications that result from conservative treatment without surgery.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Clinical Efficacy of Topical Tacrolimus on Conjunctival Hyperemia Caused by Prostaglandin Analogues

To evaluate the clinical efficacy of tacrolimus ophthalmic solution on conjunctival hyperemia caused by prostaglandin analogues.Methods.A retrospective analysis was performed on 120 patients diagnosed with bilateral primary open-angle glaucoma (poag).The enrolled patients developed symptoms of conjunctival hyperemia during the administration of travoprost ophthalmic solution.The patients were divided into two groups: 0.004% travoprost solution was administered in the control group.A combination of 0.004% travoprost solution with tacrolimus was administered in the experimental group.Clinopathological parameters including intraocular pressure (iop), subjective dry eye symptom score (sdes), hyperemia score, and noninvasive tear break-up time (nibut) were recorded at week 0, 1, 2, and 4.Two-way anova for repeated measurement was employed for statistical analysis using spss 22.0 software.Results.At week 1, 2, and 4, the iop and sdes of both the control and experimental groups were significantly lower when compared the values at week 0 (before treatment).No significant differences in the iop values between the two groups were observed at all time points.At week 2, the sdes and hyperemia score were lower in the experimental group than those in the control group, and the nibut was significantly longer in the experimental group.The above parameters showed no significant difference at week 4 between the two groups, although the average sdes and hyperemia score were slightly lower in the experimental group.Conclusion.Tacrolimus ophthalmic solution can relieve conjunctival hyperemia, improve ocular surface conditions, and reduce discomfort caused by prostaglandin analogues.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;Research Article;
The Analysis of the Effect of Blood Transfusion on Changes of Blood Platelet Parameters in Patients with Leukemia Treated with Chemotherapy

To study and analyze the effect of blood transfusion on the change of blood platelet parameters in patients with leukemia treated with chemotherapy.Methods.Ninety-eight patients with leukemia treated with chemotherapy in the first affiliated hospital of xi’an jiaotong university from january 2021 to january 2022 were selected to observe the changes of platelet parameters before and after blood transfusion.Results.There was significant difference between pre-transfusion and post-transfusion indexes (platelet count, mean platelet volume, and hematocrit) ( p &lt; 0.05 ).After binary logistic regression analysis, the use of antibiotics (or = 2.235), blood transfusion history (or = 3.086), abnormal white blood cell count (or = 1.134), and frozen plasma transfusion (or = 3.121) were the main factors of blood platelet parameters after transfusion in leukemia patients ( p &lt; 0.05 ).Conclusion.Blood transfusion is beneficial to improve blood platelet parameters and prevent bleeding in patients with leukemia treated with chemotherapy.Attention should be paid to patients with risk factors for poor response to blood platelet transfusion and early intervention.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
The Change of Aqueous Humor Cytokine Levels after Anti-VEGF in Diabetic Macular Edema: A Systematic Review and Meta-Analysis

Diabetic macular edema (dme) is a vision-threatening complication that severely impairs vision, and vegf has a certain improvement effect on it as a growth factor.Objective.To assess the alterations of different aqueous humor cytokine concentrations after intravitreal antivascular endothelial growth factor (vegf) treatment for diabetic macular edema (dme).Methods.We searched pub med, embase, and the cochrane library from inception up to may 2022 for studies evaluating the alterations of different aqueous humor cytokine concentrations after intravitreal anti-vegf treatment for diabetic macular edema.The estimates from eligible studies were meta-analyzed by the hartung–knapp/sidik–jonkman random-effects method.Egger’s regression test was used to determine the publications’ bias.A 95% confidence interval was calculated across studies.The analysis was performed using statatm version 15 software.Results.Nine eligible studies involving a total of 209 eyes for our systematic review were identified through our search strategy.The mean differences in 1-month and 2-month changes of vegf were 110.681 pg/ml ( p &lt; 0.001 ) and 283.474 pg/ml ( p = 0.003 ), respectively.The mean difference in 2-month changes of interleukin 6 (il-6) was −24.784 pg/ml ( p = 0.037 ).The mean difference in 3-month changes of central macular thickness was 130.372 μm ( p &lt; 0.001 ).Conclusions.Intravitreal injection of anti-vegf exerts a protective effect on macular edema secondary to diabetic retinopathy by affecting various cytokine concentrations, especially reducing aqueous vegf concentrations and interleukin 6 in patients with dme.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Meta-Analysis;
Research on the Correlation of Peripheral Blood Inflammatory Markers with PCT, CRP, and PCIS in Infants with Community-Acquired Pneumonia

S.This study aimsto investigate the relationship between peripheral blood neutrophil/lymphocyte ratio (nlr), platelet/lymphocyte ratio (plr), systemic immune-inflammatory index (sii), and procalcitonin (pct), c-reactive protein (crp), and pediatric critical illness score (pcis) in infants with community-acquired pneumonia (cap).Methods.100 infants with bacterial cap admitted to our hospital between january 2021 and december 2021 were selected as the infected group, and another 100 healthy infants who underwent health check-ups at the same time were selected as the control group, and the nlr, plr, and sii of peripheral blood of infants in both groups and the serum pct, crp, and pcis scores of infants in the infected group were tested.The correlation between nlr, plr, sii, and pct, crp, and pcis was analyzed by spearman’s analysis.Results.The peripheral blood levels of nlr, plr, and sii were higher in the infected group than in the control infants ( p &lt; 0.05 ).The roc results showed that the aucs of peripheral blood nlr, plr, and sii for the diagnosis of infants with cap were 0.934, 0.737, and 0.882, respectively.The roc results showed that the aucs of peripheral blood nlr, plr, and sii for assessing the extent of disease in infants with cap were 0.815, 0.710, and 0.813, respectively, with best cut-off values of 2.05, 98.57, and 823.41; the joint predicted auc was 0.862.Conclusions.Nlr, plr, and sii were significantly elevated in the peripheral blood of infants with cap, positively correlated with pct and crp, and negatively correlated with psic scores, and nlr and sii also have some guiding value in early diagnosis and assessment of the extent of the disease in infants and toddlers with cap.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Efficacy Evaluation of the VFQ-25 Scale in Patients with Different Degrees of Vitreous Opacity After Nd : YAG Laser Ablation

To evaluate the effect of the vfq-25 scale on the efficacy of nd : yag laser ablation in patients with different severity of vitreous opacities.Methods.From january 2020 to march 2021, data of patients who presented to our department and were diagnosed with vitreous opacity were collected, and the severity of vitreous opacity was divided into four grades: i, ii, iii, and iv.Preoperative visual acuity, intraocular pressure, dilated fundus, b ultrasound, and other examinations were performed, and the patients were scored using the vfq-25 scale.All patients underwent nd : yag laser ablation and were followed for 6 months.The vfq-25 scale was again used postoperatively to score the patient’s efficacy.The general information and clinical characteristics of the patients we collected.The spearman’s test was used to evaluate the correlation between vfq-25 score and nd : yag laser efficacy in patients.Results.A total of 80 patients (95 eyes) were included in this study.Vitreous opacities were grade i in 56 eyes (58.9%), grade ii in 22 eyes (23.2%), grade iii in 10 eyes (10.5%), and grade iv in 7 eyes (7.4%).Compared with preoperative scores, patients with vitreous opacity had significantly higher postoperative scores in terms of overall health (36.54 ± 17.06 vs 33.52 ± 16.74), overall visual acuity (60.39 ± 14.24 vs 57.56 ± 13.13), color vision (88.94 ± 12.56 vs 86.38 ± 12.37), and peripheral visual acuity (74.06 ± 18.38 vs 72.20 ± 18.79) items (all p &lt; 0.001 ).The overall response rates of vitreous opacities i, ii, iii, and iv were 100%, 90.9%, 80.0%, and 71.4%, respectively.There was a significant correlation between the postoperative vfq-25 total score, and the therapeutic effect of laser ablation for grade i vitreous opacities, with a correlation coefficient r of 0.417 ( p = 0.001 ).The correlation coefficient r between the total score of postoperative vfq-25 and the treatment effect of grade ii vitreous opacity was 0.622 ( p = 0.002 ).However, the correlation between the postoperative efficacy of grade iii and iv patients and the vfq-25 score was not significant.Conclusion.In patients with different degrees of vitreous opacity undergoing nd : yag laser vitreous ablation, the overall health, overall visual acuity, color vision, and peripheral visual acuity were improved after surgery, and the vfq-25 score was significantly correlated with the postoperative efficacy, which is worthy of clinical use.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Efficacy of Dexamethasone versus Dexmedetomidine Combined with Local Anaesthetics in Brachial Plexus Block: A Meta-Analysis and Systematic Review

Both dexamethasone and dexmedetomidine are commonly used local anaesthetic adjuvants in brachial plexus block to enhance the blocking effect.However, it is unclear which of the two drugs is more effective in a brachial plexus block.This article compares the effects of dexamethasone and dexmedetomidine combined with local anaesthetics in brachial plexus block through meta-analysis, availing information for current practice and future research.Methods.We conducted a search of the pub med, embase, cochrane library, and web of science databases to identify studies investigating the effects of dexamethasone and dexmedetomidine combined with local anaesthetics on brachial plexus block.The databases were searched from their inception to october 2021.Clinical randomized controlled trials were included.Two researchers independently conducted literature screening.The cochrane system review manual was adopted for literature quality evaluation, whereas stata 14.0 software aided in the meta-analysis.The duration of analgesia was the primary outcome indicator; whereas, the secondary outcome indicators included the duration of sensory block and motor block.Results.Seven articles were analysed, including 465 patients.Compared to the dexmedetomidine group, the dexamethasone group exhibited longer durations of analgesia (wmd = 111.29, 95% ci: 16.49–206.10, p = 0.021), sensory block (wmd = 173.20, 95% ci: 86.69–259.71, p &lt; 0.0001), and motor block (wmd = 121.03, 95% ci: 12.87–229.20, p = 0.028).Conclusion.The present meta-analysis results affirm that dexamethasone is a better local anaesthetic adjuvant in brachial plexus block that enhances the blocking effect.Nevertheless, the existing heterogeneity warrants additional large-scale, multicentre, high-quality randomized controlled trials in the future for further verification and to provide more reliable clinical evidence.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Meta-Analysis;
Application of Quantitative Assessment Strategy-Based Nursing Combined with Empathic Nursing in Patients Undergoing Tension-Free Inguinal Herniorrhaphy

This study aimed to explore the application of quantitative assessment strategy-based nursing combined with empathic nursing in patients undergoing tension-free inguinal herniorrhaphy.Methods.82 patients who underwent tension-free inguinal herniorrhaphy in our hospital from may 2020 to december 2021 were enrolled.According to the random number table method, they were divided into three groups (a, b, and c).Patients in group a received quantitative assessment strategy-based nursing combined with empathic nursing, and group b received quantitative assessment strategy-based nursing.Group c received a routine intervention.The early recovery of the three groups was observed.Heart rate (hr), oxygen saturation (sp o2), and blood pressure (bp) were recorded before entering the operating room and at the beginning of anesthesia.Mental health continuum-short form (mhc-sf, adult version) was used to assess the psychological status.The modified barthel index (mbi) score of three groups at different time points was recorded.The complications of the three groups were observed.Results.Compared with group c, wound healing time, ambulation time, hospital stay time, and time to resume daily activities in groups a and b were significantly shorter (all p &lt; 0.05 ).At the beginning of anesthesia, hr and bp levels in the three groups were all decreased, with hr and bp levels in group a lower than those in group c and hr levels in group b lower than those in group c (all p &lt; 0.05 ).After the intervention, the scores of emotional well-being, psychological well-being, and social well-being in groups a and b were higher than those in group c and the scores of psychological well-being and social well-being in group a were higher than those in group b (all p &lt; 0.05 ).The daily living ability score of group a was higher than that of groups b and group c at discharge, one month after discharge, and three months after discharge, and the daily living ability score of group b was higher than that of group c at these three time points (all p &lt; 0.05 ).No significant differences were observed in the incidence of complication rate among the three groups (10.71%, 14.81%, and 29.63%) (χ2 = 3.616, all p &gt; 0.05 ).Conclusion.Quantitative evaluation strategy-based nursing combined with empathic nursing can effectively improve the early recovery of patients undergoing tension-free inguinal herniorrhaphy, reduce their stress response, and improve their mental health and daily living ability.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Biomarkers for Breast Adenocarcinoma Using In Silico Approaches

This work elucidates the idea of finding probable critical genes linked to breast adenocarcinoma.In this study, the geo database gene expression profile data set (gse70951) was retrieved to look for genes that were expressed variably across breast adenocarcinoma samples and healthy tissue samples.The genes were confirmed to be part of the ppi network for breast cancer pathogenesis and prognosis.In cytoscape, the cyto hubba module was used to discover the hub genes.For correlation analysis, the predictive biomarker of these hub genes, as well as gepia, was used.A total of 155 (85 upregulated genes and 70 downregulated genes) were identified.By integrating the ppi and cyto hubba data, the major key/hub genes were selected from the results.The km plotter is employed to find the prognosis of those major pivot genes, and the outcome shows worse prognosis in breast adenocarcinoma patients.Further experimental validation will show the predicted expression levels of those hub genes.The overall result of our study gives the consequences for the identification of a critical gene to ease the molecular targeting therapy for breast adenocarcinoma.It could be used as a prognostic biomarker and could lead to therapy options for breast adenocarcinoma.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Shen-Ling-Bai-Zhu-San Enhances the Antipneumonia Effect of Cefixime in Children by Ameliorating Gut Microflora, Inflammation, and Immune Response

Shen-ling-bai-zhu-san (slbzs) is used for treating gastrointestinal disorders.However, the role of slbzs in treating pneumonia in children is still unclear.Methods.In this study, children (≥2 and &lt;9 years) with pneumonia were treated with 0.1 g cefixime (cefixime group) or 0.1 g cefixime + 9 g slbzs (slbzs + cefixime).The drugs were administered twice daily for 10 days.The therapeutic effects of the two groups were compared.The white blood cell (wbc), neutrophil, and lymphocyte counts; neutrophil-lymphocyte ratio (nlr); serum inflammatory factor levels; and gut microflora were assessed.Results.The clinical efficacy of slbzs + cefixime treatment of pneumonia in children was higher than that of cefixime alone (93.3% vs.86.7%).Both cefixime and slbzs + cefixime treatments decreased the area of pulmonary inflammatory lesions, reduced white blood cell and neutrophil counts, neutrophil-lymphocyte ratio, inflammation, and increased lymphocyte count in children with pneumonia compared with those before treatment.Moreover, slbzs enhanced the anti-inflammation and immunity-enhancing effects of cefixime in children with pneumonia.Slbzs + cefixime treatment decreased enterobacter, enterococcus, bacteroides, and fusobacterium counts and increased bifidobacterium and lactobacillus counts.Compared with the cefixime treatment group, the count of the six bacterial strains in the slbzs + cefixime treatment group was closer to the normal level.Conclusion.Slbzs enhanced the antipneumonia effect of cefixime in children with pneumonia by ameliorating gut microflora, inflammation, and immune response.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Deep Neural Networks for Optimal Selection of Features Related to Flu

In recent times, humans who have been exposed to influenza a viruses (iav) may not become hostile.Despite the fact that klrd1 has been discovered as an influenza susceptibility biomarker, it remains to be seen if pre-exposure host gene expression can predict flu symptoms.In this paper, we enable the examination of flu using deep neural networks from input human gene expression datasets with various subtype viruses.This study enables the utilization of these datasets to forecast the spread of flu and can provide the necessary steps to eradicate the flu.The simulation is conducted to test the efficiency of the model in predicting the spread against various input datasets.The results of the simulation show that the proposed method offers a better prediction ability of 2.98% more than other existing methods in finding the spread of flu.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;