syedzayyan/paper_mill_benchmark huggingface dataset:
Co-Occurring Obsessive-Compulsive and Posttraumatic Stress Disorder: A Review of Conceptualization, Assessment, and Cognitive Behavioral Treatment.

Posttraumatic stress disorder (ptsd) co-occurs with obsessive-compulsive disorder (ocd) nearly 25% of the time, and rates of co-occurring ocd within ptsd populations are even higher.Several studies examining the impact of co-occurring ocd and ptsd with suggest attenuated treatment response, yet findings regarding symptom presentation in this population are mixed.Given phenotypic, functional, and sometimes etiological overlap in ocd and ptsd, differential diagnosis and specialized treatment can be a complex yet important undertaking.This paper reviews the current literature on co-occurring ocd and ptsd; describes the theoretical conceptualization for the intersection of ocd and ptsd; offers recommendations for differential assessment and cognitive behavioral treatment; and provides directions for future research on co-occurring ocd and ptsd.

Journal: Journal of cognitive psychotherapy (2022)
Publication types: Journal Article;Review
Complete Closed Genome Sequence of the Inulin-Utilizing Lactiplantibacillus plantarum Strain Lp900, Obtained Using a Hybrid Nanopore and Illumina Assembly.

Lactiplantibacillus plantarumis a genetically and phenotypically diverse lactic acid bacterium species.We announce the hybridde novoassembly of oxford nanopore technologies and illumina dna sequence reads, producing a closed circular chromosome of 3,206,992 bp and six plasmids of the inulin-utilizing l.Plantarumstrain lp900.

Journal: Microbiology resource announcements (2021)
Publication types: Journal Article
Clinical presentation and survival outcomes of well-differentiated thyroid cancer in Filipinos.

Filipinos have higher recurrence rates compared to other racial/ethnic groups, which might suggest a higher propensity for aggressive disease.The goal of this study was to perform a population-based analysis of disease extent at diagnosis and survival outcomes in filipino patients with well-differentiated thyroid cancer relative to other racial/ethnic groups.Methods the study cohort comprised adult patients with well-differentiated thyroid cancer diagnosed between 2004 and 2015, identified in the california cancer registry.Rates of extrathyroidal extension, nodal metastasis, and distant metastasis were compared between filipinos, non-filipino asians, and non-asians using multilevel logistic regression models.Survival outcomes were compared using cox regression models, utilizing a sequential modeling approach.Results filipino ethnicity was associated with extrathyroidal extension (or 1.35, 95% ci 1.11-1.63) compared with non-asians and non-filipino asians.Filipino ethnicity was also associated with nodal metastasis (or 1.32, 95% ci 1.18-1.46), and with worse os (hazard ratio [hr] 1.45, 95% ci 1.20-1.75) and dss (hr 1.51, 95% ci 1.12-2.04).After adjusting for demographic and clinical factors, filipino ethnicity was no longer associated with os (hr 1.03, 95% ci 0.84-1.25) or dss (hr 0.93, 95% ci 0.68-1.28).Conclusion filipino patients with thyroid cancer are more likely to present with locoregionally advanced disease compared with non-filipino asians and non-asians.Furthermore, filipino patients have worse survival outcomes compared with non-filipino asians and non-asians.However, this appears to be driven by the higher rates of locoregionally advanced disease in filipino patients.

Journal: Cancer medicine (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, P.H.S.
Patients with sentinel lymph node positive melanoma: Who needs completion lymph node dissection?

Introduction completion lymph node dissection (clnd) for melanoma after positive sentinel lymph node biopsy (slnb) was recently shown to improve regional but not overall survival, likely due to the majority of patients harboring no further nodal disease.We sought to determine predictors of non-sentinel node (nsn) positivity.Methods retrospective review of prospectively collected data on melanoma patients undergoing slnb.Results 116 patients underwent 119 clnds.The incidence of nsn positivity was 17.6%; the average number of positive nsns in those cases was 1.5.Cervical and inguinofemoral location were most likely to yield positive nsn(s) (40% each).Conversely, the axilla was least likely at 18% (p < 0.001).The average number of nodes harvested was 13 for nsn negative cases and 20 for nsn positive cases (p = 0.005).Tumor thickness increased the probability of positive nsn(s) (or 1.2, p = 0.02).Conclusions tumor thickness and nodal basin were predictors of nsn metastasis, factors that could help determine which patients may benefit from clnd.Further, clnds with fewer nodes may inadequately clear residual nodal disease.

Journal: American journal of surgery (2018)
Publication types: Journal Article
Distance learning, technological devices, lifestyle and behavior of children and their family during the COVID-19 lockdown in Lombardy: a survey.

The covid-19 pandemic and the subsequent national lockdowns, school closures and distance learning may have had both negative and positive effects on physical and mental health of children.Methods a cross-sectional study was conducted on a large group of children between 1 and 10 years old in lombardy, italy (n = 3392).Their parents filled in a survey answering single or multiple-choice questions about their offspring's behavior changes (including sleep, dietary habits, emotional disturbances), relationship with siblings, parents and peers, the use of digital technologies, and distance learning experience during the lockdown.Results parents reported lifestyles and emotional alterations during the lockdown.The modifications of family relationships, parents' remote working, and screen time were associated with sleep, emotional and behavioral modifications.Distance learning was overall considered adequate.Conclusions this study reported the most updated data on the effects of covid-19 pandemic lockdown on children between 1 and 10 years of age in a large sample of italian schoolchildren.The results of this study point out that pediatricians and authorities should support relationships within families during the covid-19 pandemic.Parents' remote working might play an important role for this purpose.

Journal: Italian journal of pediatrics (2021)
Publication types: Journal Article
In vitro anti-inflammatory and wound healing properties ofAndrographis echioidesand Andrographis paniculata.

Andrographis echioides(l.) is an annual herbaceous plant in the family acanthaceae.Anti-inflammatory is the property of a substance or treatment that reduces inflammation or swelling.Antioxidants are substances that can prevent or slow damage to cells caused by free radicals, unstable molecules that the body produces as a reaction to environmental and other pressures.They are sometimes called "free-radical scavengers.Therefore, it is of interest to analyse the anti-inflammatory and antioxidant properties of andrographis echioidesand andrographis paniculata.Protease inhibitor activity was done by bovine serum albumin was added to 100μl of plant sample with increase in concentrations (100-500μg/ml).Invitro antioxidant activity was done by dpph free radical scavenging assay.200 μl of 0.1 m m dpph prepared in methanol was added to 100 μl of the plant extract with increase in concentration.Based on the results from the present study, it can be concluded that a.echioidesis found to be a good natural antioxidant source and a.Paniculatais found to be a good anti-inflammatory source.However, both the plant a.echioidesand a.paniculata have these properties.Data shows that both a.echioidesand a.Paniculatahave potential anti-inflammatory and antioxidant activity which could be due to the presence of bioactive compounds present in the plant extracts.

Journal: Bioinformation (2022)
Publication types: Journal Article
Model development and update of portable NIRS instrument for assessment of internal quality attributes of two navel orange varieties.

The variation of fruit among batches influences the performance of the portable near infrared spectroscopy (nirs) instrument and then determines the success or failure for practical application in fruit industry.Model development and update methods were investigated for determining soluble solids contents (ssc) and titrable acidity (ta) of navel orange.The pretreatment and variable selection methods were explored for building partial least square regression (plsr) models.The best models, developed by the combination of second derivative (2d) and variable sorting for normalization (vsn), could predict ssc but not ta.The root mean square error of prediction (rmsep), coefficient of determination for prediction (rp2) and ratio of prediction to deviation (rpd) for ssc were 0.66 °brix, 0.66 and 1.73.Model maintain methods of model update (mu) and slope and bias correction (sbc) achieved the best results in predicting ssc for two external validation sets with rp2, rmsep and rpd of 0.54, 0.83 °brix, 1.60 and 0.52, 0.83 °brix, 1.65, respectively.The results suggested model development and update with mu and sbc could improve the robustness of the portable nirs instrument in predicting ssc of navel orange.

Journal: Frontiers in nutrition (2022)
Publication types: Journal Article
Individual-Level Trajectories of Religiosity during Adolescence and Their Implications for Purpose.

Cohort-comparison studies suggest that adolescent religiosity has been declining over recent decades; however, work is needed on individual differences in patterns of change in religiosity throughout adolescence.The current study seeks to evaluate religiosity trends for adolescents as they transition from 6thto 12thgrade, using seven annual waves of data, and whether these patterns of change were associated with later sense of purpose.Participants (n= 824; 50.7% female; 85.1% caucasian) completed annual measures of religiosity from 6thto 12thgrade, and a measure of sense of purpose at age 21 as part of the oregon youth substance use project.Findings from latent growth models suggest both a mean-level decline in religiosity as well as individual differences in patterns of change across time.Furthermore, the intercept and change in religiosity throughout adolescence positively predicted sense of purpose at age 21.Results are discussed with respect to how individual differences occur in religiosity, and what that means for purpose development throughout adolescence.

Journal: Psychology of religion and spirituality (2022)
Publication types: Journal Article
Application of multivariate modeling for radiation injury assessment: a proof of concept.

Multivariate radiation injury estimation algorithms were formulated for estimating severe hematopoietic acute radiation syndrome (h-ars) injury (i.e., response category three or rc3) in a rhesus monkey total-body irradiation (tbi) model.Classical cbc and serum chemistry blood parameters were examined prior to irradiation (d 0) and on d 7, 10, 14, 21, and 25 after irradiation involving 24 nonhuman primates (nhp) (macaca mulatta) given 6.5-gy (60)co υ-rays (0.4 gy min(-1)) tbi.A correlation matrix was formulated with the rc3 severity level designated as the "dependent variable" and independent variables down selected based on their radioresponsiveness and relatively low multicollinearity using stepwise-linear regression analyses.Final candidate independent variables included cbc counts (absolute number of neutrophils, lymphocytes, and platelets) in formulating the "cbc" rc3 estimation algorithm.Additionally, the formulation of a diagnostic cbc and serum chemistry "cbc-schem" rc3 algorithm expanded upon the cbc algorithm model with the addition of hematocrit and the serum enzyme levels of aspartate aminotransferase, creatine kinase, and lactate dehydrogenase.Both algorithms estimated rc3 with over 90% predictive power.Only the cbc-schem rc3 algorithm, however, met the critical three assumptions of linear least squares demonstrating slightly greater precision for radiation injury estimation, but with significantly decreased prediction error indicating increased statistical robustness.

Journal: Computational and mathematical methods in medicine (2014)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Recurrent superficial venous thrombophlebitis because of mutations in the protein C and fibrinogen genes in a young Argentinian female.

hypodysfibrinogenemia and protein c deficiency are coagulopathies and in this report, we describe a young patient with both defects confirmed by molecular genetic tests.The patient was a 24-year-old woman referred for recurrent thrombophlebitis and finally deep venous thrombosis.Routine coagulation studies revealed mild decrease of protein c (0.49 iu, reference values 0.7-1.40 iu) and hypodysfibrinogenemia (0.88 g/l and 1.83 g/l for activity and antigen, respectively, reference values 2.0-4.0 g/l).Direct sequencing analyses were performed on fga, fgb, and fgg genes to confirm hypodysfibrinogenemia and on the protein c gene to confirm protein c deficiency.As a result, the patient was shown to be heterozygous p.ala82gly in the fgg gene (fibrinogen dunedin) and for compound heterozygous missense mutation in protein c gene.To our knowledge, this is the first report on a case of combined dysfibrinogenemia and protein c deficiency confirmed by molecular genetic tests.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis (2019)
Publication types: Case Reports;Journal Article
Leading Topics in Twitter Discourse on JUUL and Puff Bar Products: Content Analysis.

In response to the recent government restrictions, flavored juul products, which are rechargeable closed-system electronic cigarettes (e-cigarettes), are no longer available for sale.However, disposable closed-system products such as the flavored puff bar e-cigarette continues to be available.If e-cigarette consumers simply switch between products during the current government restrictions limited to 1 type of product over another, then such restrictions would be less effective.A step forward in this line of research is to understand how the public discusses these products by examining discourse referencing both puff bar and juul in the same conversation.Twitter data provide ample opportunity to capture such early trends that could be used to help public health researchers stay abreast of the rapidly changing e-cigarette marketplace.Objective the goal of this study was to examine public discourse referencing both puff bar and juul products in the same conversation on twitter.Methods we collected data from twitter's streaming application programming interface between july 16, 2019, and august 29, 2020, which included both "puff bar" and "juul" (n=2632).We then used an inductive approach to become familiar with the data and generate a codebook to identify common themes.Saturation was determined to be reached with 10 themes.Results posts often mentioned flavors, dual use, design features, youth use, health risks, switching 1 product for the other, price, confusion over the differences between products, longevity of the products, and nicotine concentration.Conclusions on examining the public's conversations about puff bar and juul products on twitter, having described themes in posts, this study aimed to help the tobacco control community stay informed about 2 popular e-cigarette products with different device features, which can be potentially substituted for one another.Future health communication campaigns may consider targeting the health consequences of using multiple e-cigarette products or dual use to reduce exposure to high levels of nicotine among younger populations.

Journal: Journal of medical Internet research (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
The Application of an Augmented Gravity Model to Measure the Effects of a Regionalization of Potential Risk Distribution of the US Cull Sow Market.

The continuous threat of foreign animal disease (fad) is real and present for the u.s.Swine industry.Because of this, the industry has developed plans to ensure business continuity during a fad outbreak.A core aspect of these plans is regional standstill orders of swine movements to prevent disease spread following a fad introduction.Unfortunately, there is a dearth of information about the impact of such practices on animal movements throughout the remaining swine marketing channel.This study utilizes a simplified gravity model, to understand the effects of standstill orders on individual states.The effect of each closure on the established trade patterns is determined by monitoring changes in a ppml regression coefficients of the model.Model validation compared the predicted impact of the closure of a terminal processing facility against a real-life closure dataset collected during the sars-co v-2 pandemic.The analysis determined that both the population size and location of the closure affected the observed trade patterns.These findings suggest that using a regional stop movement order may complicate disease introduction preparation as each policy comes with its own potential outcome, shifting the geospatial distribution of area risk posed by these cull populations.

Journal: Veterinary sciences (2022)
Publication types: Journal Article
Effect of intraoperative personalized goal-directed hemodynamic management on acute myocardial injury in high-risk patients having major abdominal surgery: a post-hoc secondary analysis of a randomized clinical trial.

Acute myocardial injury is common after noncardiac surgery and associated with mortality.Impaired intraoperative cardiovascular dynamics are a risk factor for acute myocardial injury.Optimizing intraoperative cardiovascular dynamics may thus reduce acute myocardial injury.We aimed to investigate the effect of intraoperative personalized goal-directed hemodynamic management on the incidence of acute myocardial injury.We hypothesized that personalized goal-directed hemodynamic management reduces the incidence of acute myocardial injury compared to routine hemodynamic management in high-risk patients having major abdominal surgery.We performed a post-hoc secondary analysis of a randomized clinical trial including 180 high-risk major abdominal surgery patients that were randomized to personalized goal-directed hemodynamic management or routine hemodynamic management.We compared the incidences of acute myocardial injury-defined according to the fourth universal definition of myocardial infarction (2018)-between patients randomized to personalized goal-directed hemodynamic management or routine hemodynamic management by calculating the relative and absolute risk reduction together with 95% wald confidence intervals and p values.Acute myocardial injury occurred in 4 of 90 patients (4%) in the personalized goal-directed hemodynamic management group and in 12 of 90 patients (13%) in the routine hemodynamic management group (relative risk: 0.33, 95% confidence interval: 0.11 to 0.99, p = 0.036; absolute risk reduction: - 9%, 95% confidence interval: - 17% to - 0.68%, p = 0.034).In this post-hoc secondary analysis, intraoperative personalized goal-directed hemodynamic management reduced the incidence of acute myocardial injury compared to routine hemodynamic management in high-risk patients having major abdominal surgery.This needs to be confirmed in larger prospective trials.

Journal: Journal of clinical monitoring and computing (2022)
Publication types: Randomized Controlled Trial;Journal Article
Loss of Drosophila FMRP leads to alterations in energy metabolism and mitochondrial function.

Fragile x syndrome (fxs), the most prevalent form of inherited intellectual disability and the foremost monogenetic cause of autism, is caused by loss of expression of the fmr1 gene .Here, we show that dfmr1 modulates the global metabolome in drosophila.Despite our previous discovery of increased brain insulin signaling, our results indicate that dfmr1 mutants have reduced carbohydrate and lipid stores and are hypersensitive to starvation stress.The observed metabolic deficits cannot be explained by feeding behavior, as we report that dfmr1 mutants are hyperphagic.Rather, our data identify dfmr1 as a regulator of mitochondrial function.We demonstrate that under supersaturating conditions, dfmr1 mutant mitochondria have significantly increased maximum electron transport system (ets) capacity.Moreover, electron micrographs of indirect flight muscle reveal striking morphological changes in the dfmr1 mutant mitochondria.Taken together, our results illustrate the importance of dfmr1 for proper maintenance of nutrient homeostasis and mitochondrial function.

Journal: Human molecular genetics (2018)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
Pediatric non-alcoholic fatty liver disease predicted by anthropometric values through transient elastography.

Non-alcoholic fatty liver disease (nafld) is the leading cause of pediatric chronic liver disease, which is strongly associated with obesity.Transient elastography, together with anthropometric values including waist-to-height ratio (wht r) and body mass index (bmi) z-scores are a more precise diagnostic method of nafld than ultrasonography.Through transient elastography, we investigate the principal anthropometric values associated with pediatric nafld.Methods healthy children between the ages of 6-18 years whose bmis were ≥85% of normal were recruited as the overweight-and-obese group, and children whose bmis ranged between 5%-85% were recruited as the control group.Non-alcoholic fatty liver disease was evaluated via transient elastography.Bmi z-score and wht r were measured.Results a total of 107 (58 overweight-and-obese, 49 control) children were recruited.As evaluated by transient elastography, children in the overweight-and-obese group had significantly higher controlled attenuation parameter and liver stiffness measurement values than the control group.To detect fatty liver, wht r with a cut-off point of 0.481 and bmi z-score with cut-off point of 1.075 had the best sensitivity and specificity.To identify liver stiffness or inflammation, wht r with cut-off point of 0.514 and bmi z-score with cut-off point of 1.62 had the best sensitivity and specificity.Controlled attenuation parameter demonstrated a fair correlation with wht r and bmi z-scores, even in the normal range of these parameters.Conclusions transient elastography together with anthropometric measurements demonstrate that pediatric nafld may develop earlier than expected.We present principal anthropometric values associated with pediatric nafld.

Journal: Pediatrics international : official journal of the Japan Pediatric Society (2021)
Publication types: Journal Article