syedzayyan/paper_mill_benchmark huggingface dataset:
MIIP functions as a novel ligand for ITGB3 to inhibit angiogenesis and tumorigenesis of triple-negative breast cancer.

Migration and invasion inhibitory protein (miip) has been identified as a tumor suppressor in various cancer types.Although miip is reported to exert tumor suppressive functions by repressing proliferation and metastasis of cancer cells, the detailed mechanism is poorly understood.In the present study, we found miip is a favorable indicator of prognosis in triple-negative breast cancer.Miip could inhibit tumor angiogenesis, proliferation, and metastasis of triple-negative breast cancer cells in vivo and in vitro.Mechanistically, miip directly interacted with itgb3 and suppressed its downstream signaling.As a result, β-catenin was reduced due to elevated ubiquitin-mediated degradation, leading to downregulated vegfa production and epithelial mesenchymal transition.More importantly, we found rgd motif is essential for miip binding with itgb3 and executing efficient tumor-suppressing effect.Our findings unravel a novel mechanism by which miip suppresses tumorigenesis in triple-negative breast cancer, and miip is thus a promising molecular biomarker or therapeutic target for the disease.

Journal: Cell death & disease (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Progression of untreated gastric and pulmonary metastasis in a patient with resected acral melanoma.

We report a man in his 80s who presents with epigastric abdominal pain and fatigue for 2 weeks.His medical history was significant for left toe acral melanoma (excised 6 years prior) and a lung mass, further workup for which was declined at the time by the patient.On presentation, he had iron deficiency anaemia and esophagogastroduodenoscopy revealed a gastric mass.Histopathological analysis of gastric and subsequently, pulmonary, lesions were consistent with metastatic melanoma.This case demonstrates the unique slow progression of untreated pulmonary metastasis in metastatic melanoma.

Journal: BMJ case reports (2022)
Publication types: Case Reports;Journal Article
Family APGAR and treatment outcomes among HIV patients at two ART Centres in Kumasi, Ghana.

S this study aimed to examine the association between family adaptability, partnership, growth, affection and resolve (family apgar) and hiv treatment outcomes.Design a cross-sectional study using the family apgar questionnaire.Setting the study was conducted in kumasi, ghana, at the komfo anokye teaching hospital and the kwame nkrumah university of science and technology hospital.Participants consenting hiv-positive patients who had been on treatment for at least 12 months were recruited.Main outcome measures the family apgar questionnaire was administered, and relevant data were extracted from hospital records and analysed using stata®software.The relationship between family apgar and treatment outcomes was determined using chi-squared tests or fisher's exact test.Results approximately 70.1% of 304 participants were females with a mean age of 41.8 years (±9.9).At treatment initiation, 47.4% of the patients presented at world health organisation (who) clinical stages i and ii and had a cd4 count ≥ 200 cells/mm3.Females were less likely (odds ratio= 0.52; 95% ci=0.31 - 0.90, p = 0.018) to report late for treatment compared with the males.After 12 months of treatment, approximately 70% recorded undetectable viral load.Patients with functional families constituted 70.4%, which had a statistically significant relationship with viral load (p = 0.041).Conclusion hiv care providers should incorporate family functionality evaluation into clinical practice and provide early essential support to enhance treatment outcomes.Funding none declared.

Journal: Ghana medical journal (2022)
Publication types: Journal Article
Obstructive Sleep Apnea and Atrial Fibrillation.

Atrial fibrillation (af) is the most common arrhythmia, increasing with age and comorbidities.Obstructive sleep apnea (osa) is a chronic sleep disorder more common in older men.It has been shown that osa is linked to af.Nonetheless, the prevalence of osa in patients with af remains unknown because osa is significantly underdiagnosed.This review, including 54,271 patients, carried out a meta-analysis to investigate the association between osa and af.We also performed a meta-regression to explore cofactors influencing this correlation.A strong link was found between these two disorders.The incidence of af is 88% higher in patients with osa.Age and hypertension independently strengthened this association, indicating that osa treatment could help reduce af recurrence.Further research is needed to confirm these findings.Atrial fibrillation (af) is the most common arrhythmia, increasing with age and comorbidities.Obstructive sleep apnea (osa) is a regulatory respiratory disorder of partial or complete collapse of the upper airways during sleep leading to recurrent pauses in breathing.Osa is more common in older men.Evidence exists that osa is linked to af.Nonetheless, the prevalence of osa in patients with af remains unknown because osa is underdiagnosed.In order to investigate the incidence of af in osa patients, we carried out a meta-analysis including 20 scientific studies with a total of 54,271 subjects.Af was present in 4801 patients of whom 2203 (45.9%) had osa and 2598 (54.1%) did not.Of a total of 21,074 patients with osa, 2203 (10.5%) had af and 18,871 (89.5%) did not.The incidence of af was 88% higher in patients with osa.We performed a meta-regression to explore interacting factors potentially influencing the occurrence of af in osa.Older age and hypertension independently strengthened this association.The clinical significance of our results is that patients with osa should be referred early to the cardiologist.Further research is needed for the definition of the mechanisms of association between af and osa.

Journal: Journal of clinical medicine (2022)
Publication types: Journal Article;Review
Arnold Netter Netter (1855-1936) and infectious pathology of the nervous system.

Arnold netter (1855-1936) was a paediatrician who clinically applied the progress that his pasteurian contemporaries had made possible through their bacteriological discoveries.From a neurological point of view, he brought looking for kernig's sign into mainstream use to confirm the clinical diagnosis of meningitis and made diagnostic lumbar puncture systematic.He was one of the first to cure meningococcal and pneumococcal meningitis, long before the era of antibiotics, using subtractive lumbar puncture and intraspinal serotherapy.Netter's attentive vigilance enabled him to recognise, from its onset, the first poliomyelitis epidemic of the 20th century which took place in the summer of 1909.He described the clinical and epidemiological characteristics, identifying the viral rather than microbial origin.Netter detected the first cases of encephalitis lethargica in paris in 1918.The disease had been described by constantin von economo (1876-1931) in vienna the previous year.Netter spent fifteen years studying this new disease, which caused a pandemic a century ago.He filled in the clinical picture and used his understanding of cerebrospinal fluid and pathological anatomy to enhance knowledge and improve treatment of this neurological pathology.

Journal: Revue neurologique (2022)
Publication types: Journal Article;Review
Unusual Cause of a Cardiac Arrest in a Former African American Collegiate Athlete.

Yamaguchi-variant cardiomyopathy is an underreported but significant cause of cardiac arrest among athletes.We studied the hospital course of one patient who arrived at the emergency department after a sudden cardiac arrest while playing a recreational basketball game.We used the electronic medical record (epic) to follow the notes, labs, imaging, and procedures that were performed.Although a rare disease, yamaguchi syndrome should not be overlooked when working up a patient who has suffered a sudden cardiac arrest.Proper knowledge of automatic external defibrillators and basic cardiopulmonary resuscitation principles can have a significant positive impact, and the importance of these interventions should not be overlooked in patients with a sudden cardiac arrest.

Journal: Cureus (2022)
Publication types: Case Reports;Journal Article
Awareness and Knowledge of Pharmacists toward Biosimilar Medicines: A Survey in Jordan.

S pharmacists in all clinical settings are recognized drug experts and integral educators of biosimilar medicines.Therefore, the objective of this study was to assess pharmacists' knowledge, predictors of knowledge, and views toward biosimilar medicines in jordan.Methods a cross-sectional study was conducted in jordan during october-december 2020.An internet-based self-administrated questionnaire on knowledge and views was distributed using social media groups to the pharmacists among different areas in jordan.A descriptive and univariate analysis was performed.Binary logistic regression was conducted to determine the predictors of knowledge including all variables withp< 0.20 on univariate analysis.Results a total 536 responses were received, 502 of which were completed (93.7% response rate).A total of 52.6% of the pharmacists were knowledgeable about biosimilar medicines and the mean of knowledge level was 6.47 ± 1.62 (range 2-10).Multivariate analysis identified that respondents who had heard about biosimilars before (or = 1.942, 95% ci = 1.231-3.063,p< 0.05) was more likely to be knowledgeable.Respondents who had not taken the course or the postgraduating training course about biosimilars that were less likely to be knowledgeable (or = 0.548, 95% ci = 0.357-0.839,p< 0.05).A positive response was noted in pharmacist's view regarding the implementation of biosimilar medicines in healthcare setting, biosimilar medicine prescription related to decreased costs, self-study about biosimilar medicine, and incorporating biosimilar education program at the pharmacy school curriculum universities level.Conclusions pharmacists' views and knowledge vary regarding the particularities and key issues on biosimilar medicines in jordan.Incorporating biosimilar course in pharmacy school curriculum could improve their acceptance for future pharmacy jobs.

Journal: International journal of clinical practice (2022)
Publication types: Journal Article
The efficacy and safety of atogepant for the prophylactic treatment of migraine: evidence from randomized controlled trials.

Migraine is a common neurovascular disorder that has a severe impact on the individual daily life.Atogepant (agn-241689) is an orally ingested, small-molecule drugs belonging to calcitonin gene-related peptide receptor antagonist, which has been initiated for the prophylactic treatment of migraine.However, there is no comprehensive literature to study the efficacy and safety of atogepant for the treatment of migraine.In this article, we present a meta-analysis of the available studies.Methods medline, embase, cochrane library and clinical trials.gov were searched before october 20, 2021 for any relevant literature.Eventually, three randomized clinical trials (rcts) with 2,466 patients were included in our study.Results we pooled 2,466 patients from 3 rcts and primary outcome was mean monthly migraine days, the secondary endpoints were monthly headache days, acute medication use days per month and ≥ 50% reduction in monthly migraine days, baseline to end of trials.It was found that atogepant (10 mg, 30 mg, 60 mg once a day) led to a significant reduction in monthly migraine days (p 0.05) in outcomes of adverse events between atogepant and placebo.Conclusions atogepant has shown good efficacy and safety in the prophylactic treatment of migraine, and further studies are expected.

Journal: The journal of headache and pain (2022)
Publication types: Journal Article;Meta-Analysis
Immobilized enzyme on pulp fiber through layer-by-layer technique using cationic polyacrylamide for whitewater treatment from papermaking.

Anionic pectic substances in whitewater from papermaking are detrimental to machine operation and product quality.Pectinase was immobilized on pulp fiber using cationic polyacrylamide with layer-by-layer method to obtain bound enzyme with tunable activity and good performance for wastewater treatment.It was revealed that high charge density and low molecular weight for cationic polyacrylamide were advantageous for enzymatic activity.During the layer-by-layer adsorption process, the enzymatic activity of the immobilized enzyme increased nearly linearly with the layer number from 983 to 3074 u/g until the fourth layer.The stability of the four-layer immobilized enzyme was improved.The multilayer immobilized enzyme exhibited good reusability and storage stability compared with monolayer enzyme.At dosage of 10 u/m l, the cationic demand of the whitewater samples was reduced by 15% using four-layer immobilized enzyme.The results indicated a potential route to prepare immobilized enzyme with good performance for wastewater treatment in papermaking industry.

Journal: Bioprocess and biosystems engineering (2019)
Publication types: Journal Article
Patient-Derived Organoids as a Model for Cancer Drug Discovery.

In the search for the ideal model of tumours, the use of three-dimensional in vitro models is advancing rapidly.These are intended to mimic the in vivo properties of the tumours which affect cancer development, progression and drug sensitivity, and take into account cell-cell interactions, adhesion and invasiveness.Importantly, it is hoped that successful recapitulation of the structure and function of the tissue will predict patient response, permitting the development of personalized therapy in a timely manner applicable to the clinic.Furthermore, the use of co-culture systems will allow the role of the tumour microenvironment and tissue-tissue interactions to be taken into account and should lead to more accurate predictions of tumour development and responses to drugs.In this review, the relative merits and limitations of patient-derived organoids will be discussed compared to other in vitro and ex vivo cancer models.We will focus on their use as models for drug testing and personalized therapy and how these may be improved.Developments in technology will also be considered, including the use of microfluidics, 3d bioprinting, cryopreservation and circulating tumour cell-derived organoids.These have the potential to enhance the consistency, accessibility and availability of these models.

Journal: International journal of molecular sciences (2021)
Publication types: Journal Article;Review
Antenatal risk score for prediction of shoulder dystocia with focus on fetal ultrasound data.

Shoulder dystocia is one of the most threatening complications during delivery, and although it is difficult to predict, individual risk should be considered when counseling for mode of delivery.Objective this study aimed to develop and validate a risk score for shoulder dystocia based on fetal ultrasound and maternal data from 15,000 deliveries.Study design data were retrospectively obtained of deliveries in 3 tertiary centers between 2014 and 2017 for the derivation cohort and between 2018 and 2020 for the validation cohort.Inclusion criteria were singleton pregnancy, vaginal delivery in cephalic presentation at ≥37+0 weeks' gestation, and fetal biometry data available within 2 weeks of delivery.Independent predictors were determined by multivariate regression analysis in the derivation cohort, and a score was developed on the basis of the effect of the predictors.Results the derivation cohort consisted of 7396 deliveries with a 0.91% rate of shoulder dystocia, and the validation cohort of 7965 deliveries with a 1.0% rate of shoulder dystocia.Among all women, 13.8% had diabetes mellitus, and 12.1% were obese (body mass index ≥30 kg/m2).Independent risk factors in the derivation cohort were: estimated fetal weight ≥4250 g (odds ratio, 4.27; p=.002), abdominal-head-circumference ≥2.5 cm (odds ratio, 3.96; p<.001), and diabetes mellitus (odds ratio, 2.18; p=.009).On the basis of the strength of effect, a risk score was developed: estimated fetal weight ≥4250 g=2, abdominal-head-circumference ≥2.5 cm=2, and diabetes mellitus=1.The risk score predicted shoulder dystocia with moderate discriminatory ability (area under the receiver-operating characteristic curve, 0.69; p<.001; area under the receiver-operating characteristic curve, 0.71; p<.001) and good calibration (hosmer-lemeshow goodness-of-fit; p=.466; p=.167) for the derivation and validation cohorts, respectively.With 1 score point, 16 shoulder dystocia cases occurred in 1764 deliveries, with 0.6% shoulder dystocia incidence and a number needed to treat with cesarean delivery to avoid 1 case of shoulder dystocia of 172 (2 points: 38/1809, 2.1%, 48; 3 points: 18/336, 5.4%, 19; 4 points: 10/96, 10.5%, 10; and 5 points: 5/20, 25%, 4); 40.8% of the shoulder dystocia cases occurred without risk factors.Conclusion the presented risk score for shoulder dystocia may act as a supplemental tool for the clinical decision-making regarding mode of delivery.According to our score model, in pregnancies with a score ≤2, meaning having solely estimated fetal weight ≥4250 g, or abdominal-head-circumference ≥2.5, or diabetes mellitus, cesarean delivery for prevention of shoulder dystocia should not be recommended because of the high number needed to treat to avoid 1 case of shoulder dystocia.Conversely, in patients with a score of ≥4 with or without diabetes mellitus, cesarean delivery may be considered.However, in 40% of the shoulder dystocia cases, no risk factors had been present.

Journal: American journal of obstetrics and gynecology (2022)
Publication types: Journal Article
Difficulties and Virtues in Assessing the Potential Energy Surfaces of Carbon Clusters via DMBE Theory: Stationary Points of Cκ(κ = 2-10) at the Focal Point.

The previously reported potential energy surfaces (pess) of ground-state singlet c3and triplet c4are here utilized as input for the construction of approximate cluster expansions for larger cκ(κ = 5-10) species.Relying primarily on the double many-body expansion (dmbe) approach, global potentials are obtained by summing the total interaction energies of all atomic subclusters up to four-body terms.The notable capability of the final forms in predicting good estimates of the linear global minima and their thermochemical/structural properties may provide important insights into the structure-determining nature of the (2 + 3 + 4) terms.The main difficulties and virtues in assessing cκ's via dmbe theory are analyzed and new prospects given for the construction of global reliable pess for the target species.

Journal: The journal of physical chemistry. A (2019)
Publication types: Journal Article
A Data-Driven Optimized Mechanism for Improving Online Collaborative Learning: Taking Cognitive Load into Account.

Research on online collaborative learning has explored various methods of collaborative improvement.Recently, learning analytics have been increasingly adopted for ascertaining learners' states and promoting collaborative performance.However, little effort has been made to investigate the transformation of collaborative states or to consider cognitive load as an essential factor for collaborative intervention.By bridging collaborative cognitive load theory and system dynamics modeling methods, this paper revealed the transformation of online learners' collaborative states through data analysis, and then proposed an optimized mechanism to ameliorate online collaboration.A quasi-experiment was conducted with 91 college students to examine the potential of the optimized mechanism in collaborative state transformation, awareness of collaboration, learning achievement, and cognitive load.The promising results demonstrated that students learning with the optimized mechanism performed significantly differently in collaboration and knowledge acquisition, and no additional burden in cognitive load was noted.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Health-related quality of life in patients with COVID-19; international development of a patient-reported outcome measure.

We aimed to create a questionnaire to assess the health-related quality of life including functioning, symptoms, and general health status of adult patients with current or previous covid-19.Here, we report on phase i and ii of the development.Methods internationally recognized methodology for questionnaire development was followed.In phase i, a comprehensive literature review was performed to identify relevant covid-19 issues.Decisions for inclusion, exclusion, and data extraction were completed independently in teams of two and then compared.The resulting issues were discussed with health care professionals (hcps) and current and former covid-19 patients.The input of hcps and patients was carefully considered, and the list of issues updated.In phase ii, this updated list was operationalized into items/questions.Results the literature review yielded 3342 publications, 339 of which were selected for full-text review, and 75 issues were identified.Discussions with 44 hcps from seven countries and 52 patients from six countries showed that psychological symptoms, worries, and reduced functioning lasted the longest for patients, and there were considerable discrepancies between hcps and patients concerning the importance of some of the symptoms.The final list included 73 issues, which were operationalized into an 80-item questionnaire.Conclusion the resulting covid-19 questionnaire covers health-related quality of life issues relevant to covid-19 patients and is available in several languages.The next steps include testing of the applicability and patients' acceptability of the questionnaire (phase iiia) and preliminary psychometric testing (phase iiib).

Journal: Journal of patient-reported outcomes (2022)
Publication types: Journal Article
Antioxidant Activities of Hot Water Extracts from Mycelial Biomass of Different Combinations of Medicinal Agaricomycetes Mushrooms.

This study aimed to determine the free radical scavenging and antioxidant potential of hot water extracts prepared from different combinations and ratios of submerged cultivated mycelial biomass of medicinal mushrooms.Total phenolic compounds, flavonoid content, and antioxidant activity were evaluated for combined crude hot water extracts from medicinal higher basidiomycetes mushrooms belonging to ten genera.The results demonstrate that almost all tested combinations were good sources of phenolic compounds and flavonoids, ranging between 16.42 and 18.83 gallic acid equivalents/g and 1.5 and 4.34 mg rutin equivalents/g, respectively.Moreover, free radical scavenging properties were evaluated with the dpph and abts assays and metal chelating effects were investigated.All tested samples and/or extracts demonstrated significant free radical scavenging properties and antioxidant potential.

Journal: International journal of medicinal mushrooms (2022)
Publication types: Journal Article