syedzayyan/paper_mill_benchmark huggingface dataset:
Universal access to genetic counseling for women with epithelial ovarian cancer in Nova Scotia: Evaluating a new collaborative care model.

Women with pathogenic variants in brca1/2 have a significantly increased lifetime risk of breast and ovarian cancers.The availability of genetic testing to identify brca1/2 carriers is imperative to disease prevention and treatment.We evaluated the effectiveness of a new collaborative care model in nova scotia, involving the integration of genetic counselors into tumor board rounds, reduction in time allotted for initial genetic counseling appointments from 60 to 45 min, and a standardized dictation template, to increase referral rate for genetic counseling.We also assessed the study cohorts' preferences on timing for genetic testing.A retrospective chart review was performed on all women diagnosed with epithelial ovarian cancer (eoc) from 2012 to 2017 (n = 386).Pertinent clinical outcomes were categorized and wait times to different nodes of the clinical pathway assessed.A questionnaire was sent to this same cohort of women to identify preference for the timing of genetic testing (n = 103).The chi-square and wilcoxon's rank-sum tests were used to compare demographic and clinical variables pre- and post-care model implementation.We identified a 48.2% (95% ci: 39.4-56.7, p < .001) increase in referral for genetic counseling following implementation of the new care model.Median time from diagnosis to referral decreased by 74.0 days (p < .001) and median time from referral to first appointment by 54.0 days (p < .001).56.3% of women desired referral at the time of diagnosis.This care model for women newly diagnosed with eoc in nova scotia was successful in increasing referral rates for genetic counseling.Majority of women pursued genetic testing following and favored that referral for genetic counseling be made at the time of diagnosis, highlighting the importance for timely access.

Journal: Journal of genetic counseling (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Type 2 Diabetes and Myocardial Infarction: Recent Clinical Evidence and Perspective.

Type 2 diabetes mellitus (t2dm) and its complications are seriously affecting public health worldwide.Myocardial infarction (mi) is the primary cause of death in patients with t2dm.T2dm patients without a history of coronary artery disease (cad) have the same risk of major coronary events as those with cad; t2dm patients with a history of mi have >40% risk of recurrence of mi.Thus, cad in patients with t2dm needs to be treated actively to reduce the risk of mi.The cardiology community focused on the role of t2dm in the development of cad and on the related issues of t2dm and mi with respect to comorbidities, prognosis, drug therapy, and heredity.In this mini review, the latest progress of clinical evidence-based research between t2dm and mi in recent years was reviewed, and the possible research directions in this field were considered and prospected.

Journal: Frontiers in cardiovascular medicine (2021)
Publication types: Journal Article;Review
Origin of Red-Shifted Phosphorescence from Triphenylamines: Triplet Excimer or Impurity?

Triphenylamine (tpa) was reported to exhibit temperature-dependent dual phosphorescence, where the red-shifted band was assigned as the excimeric phosphorescence with an energy shift of >3000 cm-1(j.Phys.Chem.1991, 95, 7189).Here we show that purified tpa (purity: >99.97 %) shows a single phosphorescence band with a small energy shift of <200 cm-1under the same experimental conditions.The new experimental results, along with theoretical calculations, suggest that the previously reported triplet excimer of tpa is probably not valid and is most likely due to an unidentified impurity.As-received tpa samples, however, do exhibit temperature-dependent dual phosphorescence bands, and the wavelength, relative intensity, and temperature dependence of the lower-energy phosphorescence band vary significantly depending on dopant structures.It was found that dopant phosphorescence could still become dominant even in dilute third-party solutions of the host at low temperature.

Journal: Angewandte Chemie (International ed. in English) (2022)
Publication types: Journal Article
Variability in urinary concentrations of primary aromatic amines.

Despite their known carcinogenic potential, primary aromatic amines (aas) continue to be used in various consumer products.Human exposure to aas is a subject of current concern.Although urinary measurements are used in the assessment of exposure, little is known about within- and between-individual temporal variability in urinary concentrations of aas.In this study, we determined the concentrations of 30 aas, nicotine and cotinine in 213 first morning void (fmv) urine samples collected longitudinally for over a five-week period from 15 participants residing in the albany area of new york state, usa.Eight aas, namely, aniline, 2-naphthylamine (2-na), p-cresidine (p-cd), p-toluidine (p-td), o/m-toluidine (o/m-td), 4-chloroaniline (4-ca), 4,4'-methylenedi-o-toluidine (4,4'-mda), and 2,6-dimethylaniline (2,6-dma) were found in urine at a detection frequency (df) in the range of 68-100%.Aniline and 2,6-dma were the predominant compounds found at median concentrations of 6.0 and 3.81 ng/m l, respectively.Intraclass correlation coefficients (iccs) of all urinary aa concentrations, except for 4-ca, showed moderate to poor predictability (icc values ranged 0.248-0.697).Gender and ethnicity-related variations in ∑8aa concentrations were significant.Spearman's correlations among aa concentrations suggested that the sources of exposure were not related to tobacco smoke.No significant correlations existed between aas concentrations and oxidative stress biomarkers (osbs).The estimated daily intakes of aas calculated based on urinary concentrations were several orders of magnitude below the tolerable daily intakes.

Journal: The Science of the total environment (2022)
Publication types: Journal Article
Factors associated with retention of community health workers in maternal, newborn and child health programme in Simiyu Region, Tanzania.

Attrition of community health workers (chws) continues to threaten the full realisation and sustainability of community-based health programmes globally.Aim: this study aimed to understand factors associated with chws' recruitment and their retention.Setting: this study was conducted in five districts of the simiyu region, namely, bariadi, busega, itilima, maswa and meatu in north-western tanzania.Methods: in this cross-sectional study design, 341 chws who were working with the maternal health programme were randomly selected.Semi-structured questionnaires were administered to all participants.Data were descriptively and inferentially analysed using spss version 20.Results: majority (58.0%) of chws were below 35 years.Over half (53.1%) had completed primary education only.Motivation factors for being chw were aspiration to serve the community and desire for further training to become a qualified medical practitioner.Community recognition and financial incentives were among the key retention reasons for the chws.Being married (odds ratio [or] 5.9, 95% confidence interval [ci] 1.7-20.1) having prior volunteer experience (or 10.5 95% ci 12.7-40.5) and prior employment or 21.8 (ci 12.2-38.9) were positively associated with retention of chws, while being a female was negatively associated with retention or 0.4 (ci 0.2-0.8).Conclusions: both financial and non-financial incentives were critical in contributing to the retention of chws.Thus, health programmes should carefully select chws by understanding their motives beforehand, and provide them with incentives.

Journal: African journal of primary health care & family medicine (2018)
Publication types: Journal Article
Multimodal Evidence of Atypical Processing of Eye Gaze and Facial Emotion in Children With Autistic Traits.

According to the shared signal hypothesis (ssh) the impact of facial expressions on emotion processing partially depends on whether the gaze is directed toward or away from the observer.In autism spectrum disorder (asd) several aspects of face processing have been found to be atypical, including attention to eye gaze and the identification of emotional expressions.However, there is little research on how gaze direction affects emotional expression processing in typically developing (td) individuals and in those with asd.This question is investigated here in two multimodal experiments.Experiment 1 required processing eye gaze direction while faces differed in emotional expression.Forty-seven children (aged 9-12 years) participated.Their autism diagnostic observation schedule (ados) scores ranged from 0 to 6 in the experiment.Event-related potentials (erps) were sensitive to gaze direction and emotion, but emotion processing did not depend on gaze direction.However, for angry faces the gaze direction effect on the n170 amplitude, as typically observed in td individuals, diminished with increasing ados score.For neutral expressions this correlation was not significant.Experiment 2 required explicit emotion classifications in a facial emotion composite task while eye gaze was manipulated incidentally.A group of 22 children with asd was compared to a propensity score-matched group of td children (mean age = 13 years).The same comparison was carried out for a subgroup of nine children with asd who were less trained in social cognition, according to clinician's report.The asd group performed overall worse in emotion recognition than the td group, independently of emotion or gaze direction.However, for disgust expressions, eye tracking data revealed that td children fixated relatively longer on the eyes of the stimulus face with a direct gaze as compared with averted gaze.In children with asd we observed no such modulation of fixation behavior as a function of gaze direction.Overall, the present findings from erps and eye tracking confirm the hypothesis of an impaired sensitivity to gaze direction in children with asd or elevated autistic traits, at least for specific emotions.Therefore, we conclude that multimodal investigations of the interaction between emotional processing and stimulus gaze direction are promising to understand the characteristics of individuals differing along the autism trait dimension.

Journal: Frontiers in human neuroscience (2022)
Publication types: Journal Article
Synthesis, molecular docking and evaluation of novel sulfonyl hydrazones as anticancer agents and COX-2 inhibitors.

In trying to develop new anticancer agents, a series of sulfonylhydrazones were synthesized.All synthesized compounds were checked for identity and purity using elemental analysis, tlc and hplc and were characterized by their melting points, ft-ir and nmr spectral data.All synthesized compounds were evaluated for their cytotoxic activity against prostate cancer (pc3), breast cancer (mcf-7) and l929 mouse fibroblast cell lines.Among them, n'-[(2-chloro-3-methoxyphenyl)methylidene]-4-methylbenzenesulfonohydrazide (3k) showed the most potent anticancer activity against both cancer cells with good selectivity (ic50= 1.38 μm on pc3 with si = 432.30 and ic50= 46.09 μm on mcf-7 with si = 12.94).Further investigation confirmed that 3k displayed morphological alterations in pc3 and mcf-7 cells and promoted apoptosis through down-regulation of the bcl-2 and upregulation of bax expression.Additionally, compound 3k was identified as the most potent cox-2 inhibitor (91% inhibition) beside lower cox-1 inhibition.Molecular docking of the tested compounds represented important binding modes which may be responsible for their anticancer activity via inhibition of the cox-2 enzyme.Overall, the lead compound 3k deserves further development as a potential anticancer agent.Sulfonylhydrazones was synthesized and n'-[(2-chloro-3-methoxyphenyl)methylidene]-4- methylbenzenesulfonohydrazide (3k) was identified as the most potent anticancer agent and cox-2 inhibitor.In addition, this compound docked inside the active site of cox-2 succesfully.

Journal: Molecular diversity (2020)
Publication types: Journal Article
Intramyocardial dissecting hematoma: Two case reports and a meta-analysis of the literature.

Until recently, diagnosis of intramyocardial dissecting hematoma (idh) was performed during necropsy or at surgery.During the recent years, echocardiography has permitted clinical suspicion, which usually needed confirmation with magnetic resonance imaging (mri).In this study, we tried to define clinical and imaging features of idh and predictors of mortality.We searched the literature for proven cases of idh and analyzed them together with 2 of our cases.A total of 40 cases of idh (2 our original and 38 literature cases) were included.Mean age was 60.In 32 cases, idh was a complication of myocardial infarction (mi), in 66% anterior, a mean time from symptoms to diagnosis was 9 days.Thirty-eight % underwent surgery.In-hospital mortality was 23%.Multivariate analysis showed that the strongest independent predictor of mortality (42%) was ef 60, mortality risk was 44%; and in the presence of mi or late diagnosis (>24 hours since symptoms started), mortality risk was 50%.In summary, idh is a diagnostic challenge.A high level of suspicion is needed for prompt diagnosis.Management of these patients is based on individual clinical and imaging parameters.Low ef, age > 60, and late diagnosis, all are predictors of in-hospital mortality.

Journal: Echocardiography (Mount Kisco, N.Y.) (2018)
Publication types: Case Reports;Journal Article;Meta-Analysis
Quality of life and perceived financial implications among otorhinolaryngologists during the COVID-19 pandemic across India.

The changing trends in medical practice, uncertainties and monetary apprehensions due to the covid-19 pandemic may influence the sense of well-being among otorhinolaryngologists.The present study was conducted to evaluate quality of life (qol) and perceived financial implications in otorhinolaryngologists during the covid-19 pandemic across india.Methods a cross-sectional study was carried out among otorhinolaryngology specialists across india using whoqol-bref and consumer financial protection bureau (cfpb) financial well-being scale questionnaires on google forms, which was kept open for the latter half of july 2020.Results a total of 358 responses were obtained; the response rate was 26.64%.Twenty-four percent of respondents worked exclusively in academic settings; 40.22% of specialists had over 10 years of work experience.Average monthly income in 2019 was between 1-3 lakhs indian rupees (inr) in 43.85%, while in 2020, 62.57% of the specialists had an average monthly income of below one lakh inr; this difference was statistically significant (p < 0.001).Mean whoqol-bref scores for physical, psychological, social and environmental domains were 68.8 ± 1, 62.3 ± 0.75, 68.9 ± 1.17 and 65.8 ± 1.01, respectively; mean cfpb financial well-being scale score was 55.5 ± 0.66.Qol and financial well-being were better in otolaryngologists older than 60 years, male specialists and private consultants.Conclusions there has been a tremendous impact on quality of life and financial well-being among otorhinolaryngologists in india during the covid-19 pandemic.The study outcome may help otolaryngologists comprehend and perceive the extent to which it has affected their professional and personal lives, and explore ways to face and overcome the situation.

Journal: Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale (2021)
Publication types: Journal Article
The Hippo pathway regulates axis formation and morphogenesis inHydra.

How did cells of early metazoan organisms first organize themselves to form a body axis?The canonical wnt pathway has been shown to be sufficient for induction of axis in cnidaria, a sister group to bilateria, and is important in bilaterian axis formation.Here, we provide experimental evidence that in cnidarian hydrathe hippo pathway regulates the formation of a new axis during budding upstream of the wnt pathway.The transcriptional target of the hippo pathway, the transcriptional coactivator yap, inhibits the initiation of budding in hydraand is regulated by hydra lats.In addition, we show functions of the hippo pathway in regulation of actin organization and cell proliferation in hydra.We hypothesize that the hippo pathway served as a link between continuous cell division, cell density, and axis formation early in metazoan evolution.

Journal: Proceedings of the National Academy of Sciences of the United States of America (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Eukaryotic translation initiation factor 4E family member nCBP facilitates the accumulation of TGB-encoding viruses by recognizing the viral coat protein in potato and tobacco.

Due to their limited coding capacity, plant viruses have to depend on various host factors for successful infection of the host.Loss of function of these host factors will result in recessively inherited resistance, and therefore, these host factors are also described as susceptibility genes or recessive resistance genes.Most of the identified recessive resistance genes are members of theeukaryotic translation initiation factors 4efamily (e if4e) and its isoforms.Recently, an e if4e-type gene,novel cap-binding protein(n cbp), was reported to be associated with the infection of several viruses encoding triple gene block proteins (tgbps) in arabidopsis.Here, we, for the first time, report that the knockdown ofn cbpin potato (stn cbp) compromises the accumulation of potato virus s (pvs) but not that of potato virus m (pvm) and potato virus x (pvx), which are three potato viruses encoding tgbps.Further assays demonstrated that stn cbp interacts with the coat proteins (cps) of pvs and pvm but not with that of pvx, and substitution of pvs cp in the pvs infectious clone by pvm cp recovered the virus infection in stn cbp-silenced transgenic plants, suggesting that the recognition of pvs cp is crucial for stn cbp-mediated recessive resistance to pvs.Moreover, the knockdown of n cbp in nicotiana benthamiana(nbn cbp) by virus-induced gene silencing suppressed pvx accumulation but not pvm, while nbn cbp interacted with the cps of both pvx and pvm.Our results indicate that then cbporthologues in potato and tobacco have conserved function as in arabidopsis in terms of recessive resistance against tgb-encoding viruses, and the interaction between n cbp and the cp of tgb-encoding virus is necessary but not sufficient to determine the function ofn cbpas a susceptibility gene.

Journal: Frontiers in plant science (2022)
Publication types: Journal Article
Are the Relationships of Lean Mass and Fat Mass With Bone Microarchitecture Causal or Due to Familial Confounders? A Novel Study of Adult Female Twin Pairs.

It is not known whether the relationships of lean mass (lm) and fat mass (fm) with bone microarchitecture and geometry are causal and/or are because of confounders, including familial confounders arising from genetic and environment effects shared by relatives.We tested the hypotheses that: (i) lm is associated with cortical bone traits, (ii) fm is associated with trabecular bone traits, and (iii) these relationships of lm and fm with bone microarchitecture and geometry have a causal component.Total body composition was quantified for 98 monozygotic (mz) and 54 dizygotic (dz) white female twin pairs aged 31 to 77 years.Microarchitecture at the distal tibia and distal radius was quantified using hrp qct and str ax software.We applied the inference about causation through examination of familia l confounding (ice falcon) method.Within-individuals, distal tibia total bone area, cortical area, cortical thickness, and trabecular number were positively associated with lm (standardized regression coefficient (β) = 0.13 to 0.43; allp< 0.05); porosity of the inner transitional zone (itz) was negatively associated with lm (β =-0.22;p< 0.01).Trabecular number was positively associated with fm (β =0.40;p< 0.001), and trabecular thickness was negatively associated with fm (β = -0.27;p< 0.001).For porosity of itz and trabecular number, the cross-pair cross-trait association with lm was significant before and after adjustment for the within-individual association with lm (allps < 0.05).For trabecular number, the cross-pair cross-trait association with fm was significant before and after adjustment for the within-individual association with fm (p< 0.01).There were no significant changes in these cross-pair cross-trait associations after adjustment for the within-individual association (p= 0.06 to 0.99).Similar results were found for distal radius measures.We conclude that there was no evidence that the relationships of lm and fm with bone microarchitecture and geometry are causal; they must in part due to by familial confounders affecting both bone architecture and body composition.© 2020 the authors.jbmr pluspublished by wiley periodicals llc.On behalf of american society for bone and mineral research.

Journal: JBMR plus (2020)
Publication types: Journal Article
Isolated ureteral malakoplakia: A conservative endoscopic approach with a strict follow-up.

Ureteral malakoplakia is a rare pathological entity.We report the case of a 54-years-old woman with a single ureteral malakoplakic lesion.Patient presented with history of recurrent urinary tract infections and asymptomatic dilatation of right pelvis.Radiological investigations showed a right lower ureteric filling defect without bladder or kidney involvement.A first uretero-renoscopy allowed an extirpative biopsy, with a histopathologic diagnosis of malakoplakia.Second-look uretero-renoscopy showed only a minute area of hyperemic mucosa that was biopsied and coagulated, showing a residual focus of malakoplakia.At 12-months, imaging and blood test demonstrated reduction of hydronephrosis, serum creatinine recovery and no recurrences.

Journal: Urology case reports (2022)
Publication types: Case Reports;Journal Article
From risk to chronicity: evolution of autoreactive B cell and antibody responses in rheumatoid arthritis.

The presence of disease-specific autoantibody responses and the efficacy of b cell-targeting therapies in rheumatoid arthritis (ra) indicate a pivotal role for b cells in disease pathogenesis.Important advances have shaped our understanding of the involvement of autoantibodies and autoreactive b cells in the disease process.In ra, autoantibodies target antigens with a variety of post-translational modifications such as carbamylation, acetylation and citrullination.B cell responses against citrullinated antigens generate anti-citrullinated protein antibodies (acpas), which are themselves modified in the variable domains by abundant n-linked glycans.Insights into the induction of autoreactive b cells against antigens with post-translational modifications and the development of autoantibody features such as isotype usage, epitope recognition, avidity and glycosylation reveal their relationship to particular ra risk factors and clinical phenotypes.Glycosylation of the acpa variable domain, for example, seems to predict ra onset in acpa+healthy individuals, possibly because it affects b cell receptor signalling.Moreover, acpa-expressing b cells show dynamic phenotypic changes and develop a continuously proliferative and activated phenotype that can persist in patients who are in drug-induced clinical remission.Together, these findings can be integrated into a conceptual framework of immunological autoreactivity in ra, delineating how it develops and persists and why disease activity recurs when therapy is tapered or stopped.

Journal: Nature reviews. Rheumatology (2022)
Publication types: Journal Article;Review