syedzayyan/paper_mill_benchmark huggingface dataset:
Alteration of physiological and biochemical properties in leaves and fruits of pomegranate in response to gamma irradiation.

Pomegranate breeding to improve the marketability requires the production of large and high quality fruits.Gamma radiation on pomegranate can be used to generate genetic diversity that allows the breeder to screen the mutants for superior quality and quantity.For this purpose, dormant buds on 1-year-old shoots of pomegranate cultivar "malase saveh" were subjected to 36 gy (gy) of gamma irradiation from a cobalt (60co) source.Shoot cuttings were taken from the mutated shoots and generate m1v2.The number of 11 mutants were selected from m1v2plants based on their winter survival and disease resistance.After a period of 3-4 years, leaf and fruit samples were harvested from the m1v5.Results showed that physiological and biochemical parameters of leaves were altered unevenly, some clones showed no alterations from the control, while others revealed considerable differences.Irradiation altered various aspects related to fruit, such as the number and weight of ripe and unripe fruits, number of cracked, sunburn, worm-eaten fruits, and fruit size.In general, mutant clones 5, 8, and 10 had higher fruit sizes and weight of ripe fruits and less number and weight of unripe fruits.The stability of the detected mutants will be evaluated and new commercial field trials using selected materials will be established.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Impact of depressive disorders on clinical outcomes in patients with chronic heart failure.

Introduction to date, there are no literature reports of research investigating the relationship between depression and chronic heart failure (chf) in relation to selected nutritional, cardiac and laboratory parameters.Aim to compare chf parameters in relation to nutritional and laboratory parameters between depressed and non-depressed patients.Material and methods we enrolled 94 chf individuals from lubelskie voivodeship to assess depression prevalence and to compare values of cardiac, laboratory and nutritional parameters between depressed and non-depressed patients.Results depression was diagnosed in 66 (70.2%) individuals.We noted significantly lower ejection fraction (ef) (ef%) in the group of depressive patients compared to disease-free individuals (mean ef%: 42 ±12 and 49 ±9;p= 0.030) and worse outcomes in nyha examination (p< 0.001).Depressed patients had lower body weight (p= 0.023), body mass index (bmi) (p= 0.044), serum albumin concentration (p= 0.015), and hemoglobin concentration (p= 0.042) and an elevated level of c-reactive protein (crp) (p= 0.025) in comparison to the non-depressed group.The moderate or severely depressed group had a lower level of ef% (p= 0.019) and higher left anterior descending artery (lad) (p= 0.040) compared with the group suffering from mild depression.We observed greater susceptibility to develop cachexia in patients diagnosed as moderately or severely depressed (p= 0.030).Moreover, in the mentioned group of patients, lower values of body weight (p= 0.037), fat-free mass (ffm) (p= 0.022) and hemoglobin concentration (p= 0.007) were found.Moreover, an inverse correlation between beck depression inventory (bdi) score and ef% (r= -0.371;p= 0.017) was recorded.Conclusions depression in chf patients is associated with worse cardiac, laboratory and nutritional outcomes.Unfavorable clinical characteristics of chf patients are related to depression severity.

Journal: Postepy w kardiologii interwencyjnej = Advances in interventional cardiology (2022)
Publication types: Journal Article
Innate Immunity in Mucopolysaccharide Diseases.

Mucopolysaccharidoses are rare paediatric lysosomal storage disorders, characterised by accumulation of glycosaminoglycans within lysosomes.This is caused by deficiencies in lysosomal enzymes involved in degradation of these molecules.Dependent on disease, progressive build-up of sugars may lead to musculoskeletal abnormalities and multi-organ failure, and in others, to cognitive decline, which is still a challenge for current therapies.The worsening of neuropathology, observed in patients following recovery from flu-like infections, suggests that inflammation is highly implicated in disease progression.This review provides an overview of the pathological features associated with the mucopolysaccharidoses and summarises current knowledge regarding the inflammatory responses observed in the central nervous system and periphery.We propose a model whereby progressive accumulation of glycosaminoglycans elicits an innate immune response, initiated by the toll-like receptor 4 pathway, but also precipitated by secondary storage components.Its activation induces cells of the immune system to release pro-inflammatory cytokines, such as tnf-α and il-1, which induce progression through chronic neuroinflammation.While tnf-α is mostly associated with bone and joint disease in mucopolysaccharidoses, increasing evidence implicates il-1 as a main effector of innate immunity in the central nervous system.The (nod)-like receptor protein 3 inflammasome is therefore implicated in chronic neuroinflammation and should be investigated further to identify novel anti-inflammatory treatments.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article;Review
Synthesis of3H,2H4, and14C-MK 3814 (preladenant).

Mk 3814 is a potent and selective antagonist of the a2areceptor.A2areceptor antagonists have the potential for the treatment of parkinson disease.Three distinct isotopically labelled forms of mk 3814 were synthesized.[3h]mk 3814 was prepared for a preliminary absorption, distribution, metabolism, and excretion data (adme) evaluation of the compound and [14c]mk 3814 for more definitive adme work, including an absorption, metabolism, and excretion study in man.In addition, [2h4]mk 3814 was prepared as an internal standard for a liquid chromatography mass spectrometry bioanalytical method.This paper discusses the synthesis of 3 isotopically labelled forms of mk 3814.

Journal: Journal of labelled compounds & radiopharmaceuticals (2017)
Publication types: Journal Article
Novel pyrazolo[3,4-b]pyridine derivatives: Synthesis, structure-activity relationship studies, and regulation of the AMPK/70S6K pathway.

A series of novel pyrazolo[3,4-b]pyridine derivatives were designed, synthesized, and biologically evaluated for anti-lung cancer activity.Structure-activity relationship and auto gpa models were constructed based on the in vitro antiproliferative potency of the compounds against a human lung adenocarcinoma cell line (a549).Compound 9d exhibits improved potency for a549 cell growth inhibition (3.06 ± 0.05 μm) compared with a-769662 (45.29 ± 2.14 μm).Compound 9d can elevate the phosphorylation levels of adenosine monophosphate-activated protein kinase (ampk) and its substrate acetyl-co a carboxylase and reduce the level of phosphorylated ribosomal s6 kinase (p-70s6k) at 1 μm, which is comparable to the activity of a-769662 at 20 μm.9d induced g2/m cell cycle arrest, which was rescued when co-incubated with "compound c," a potent ampk inhibitor.Taken together, compound 9d showed potential anti-lung cancer activity via inducing cell cycle arrest by regulation of the ampk/70s6k pathway in a549 cells, which could provide a new lead for the discovery of anti-lung cancer agents.

Journal: Archiv der Pharmazie (2022)
Publication types: Journal Article
Violence, Suffering and Subversion: Notes From a Qualitative Study About Schooling Trajectories of Brazilian Young Homosexuals.

The objective of this article was to analyze the schooling trajectories of young homosexuals, as well as to verify situations that caused psychological distress in formal education environments.Three men who self-identified as homosexual participated in the research.Semi-structured, reflexive and group interviews were used as data collection methods and data were analyzed through thematic analysis.The participants' accounts revealed four key themes.1) it was evident that the participants experienced multiple forms of violence and discrimination and that they suffered psychological distress in educational environments.As a result, 2) participants tended to hide their sexual identities in the school environment, reinforcing psychological distress.A key explanatory theme in the young people's accounts was 3) institutional neglect that centered on omissions and silences in the school context, thus reinscribing their invisibility.However, despite the detrimental environment and psychological distress, homosexual young men also 4) find ways to subvert and destabilize heteronormativity.

Journal: Journal of homosexuality (2022)
Publication types: Journal Article
A Case of Perimesencephalic Subarachnoid Hemorrhage with Cerebral Venous Sinus Thrombosis due to Stenosis of the Junction of the Vein of Galen and Rectus Sinus.

Perimesencephalic subarachnoid hemorrhage (pmsah) is a group of diseases characterized by bleeding around the brainstem.In recent years, it has been suggested that pmsah is associated with the venous system.We report a case of pmsah caused by stenosis of the junction of the vein of galen (vg) and the rectus sinus (rs).A 39-year-old man presented with restlessness at work.He was administered diazepam, and a few minutes later, his consciousness became clear.Imaging showed subarachnoid hemorrhage (sah) around the right midbrain, occlusion of the right sigmoid sinus and the right transverse sinus, stenosis of the junction of the vg and rs, t2 hyperintensity in the right middle temporal gyrus, and obstruction of the right vein of labbe.The location of the sah coincided with stenosis of the junction of the vg and rs.Pmsah was diagnosed due to the increase in intracranial venous pressure caused by the patient's sinus obstruction in addition to the stenosis of the junction of the vg and rs.It is necessary to pay attention to venous return when pmsah is observed.

Journal: Case reports in neurology (2022)
Publication types: Case Reports;Journal Article
Perspectives of Low-Income and Minority Populations With Lung Cancer: A Qualitative Evaluation of Unmet Needs.

Lung cancer is the second most common cancer and the leading cause of cancer death in the united states.Persistent disparities remain in the incidence, mortality, and quality of lung cancer care received among minorities and populations with low income.This study aims to evaluate perspectives of low-income and minority patients with lung cancer on health system-level barriers and facilitators to high-quality lung cancer care delivery.Methods informed by community-based participatory research, we conducted semistructured interviews with 48 patients with lung cancer in the san francisco peninsula and central coast regions of california.We recorded, transcribed, and analyzed interviews using thematic analysis.Results participants described four major structural and process barriers in current lung cancer care: unmet psychosocial support needs, lack of understanding of precision medicine, undertreated symptoms, and financial concerns about cancer, which exacerbate concerns regarding families' well-being.Participants described that trusting relationship with their cancer care team members was a facilitator for high-quality care and suggested that proactive integration of proactive psychosocial and community-based peer support could overcome some of the identified barriers.Conclusion this study identified modifiable health system lung cancer care delivery barriers that contribute to persistent disparities.Opportunities to improve care include integration of community-based peer support.

Journal: JCO oncology practice (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Inhibitory effect of α-cubebenoate on atopic dermatitis-like symptoms by regulating Th2/Th1/Th17 balance in vivo.

Ethnopharmacological relevance bakumijiogan (kampo herbal formulation) and kangqian decoction (chinese herbal medicine formulation) have been used for the treatment of atopic dermatitis (ad) like symptoms.Schisandra chinensis baill (family: magnoliaceae) is a component of both formulations.Its extracts showed inhibition of ad.Aim of the study we aimed to elucidate an active phytochemical from schisandra chinensis and evaluated its effects on ad-like symptoms.Materials and methods we fractionated a component from schisandra chinensis by chasing inhibitory activity on mast cell degranulation.We identified α-cubebenoate as an active phytochemical and investigated its effects by using an in vivo 1-chloro-2,4-dinitrobenzene (cdnb)-induced ad model in balb/c mice.Results α-cubebenoate significantly decreased cdnb-induced skin hypertrophy and accumulation of mast cells in the epidermis and dermis.Increases in pro-inflammatory chemokine and cytokine levels in the skin, lymph node size, and immunoglobulin e levels in the serum were significantly ameliorated by α-cubebenoate.Conclusion α-cubebenoate regulates dermal immune responses by suppressing the th2/th17/th1 immune balances, resulting in amelioration of ad-like symptoms and suppression of immune response in lymph nodes.Thereby, this study provides evidence for its therapeutic efficacy in the treatment of ad symptoms.

Journal: Journal of ethnopharmacology (2022)
Publication types: Journal Article
Direct Conjugation of Resveratrol on Hydrophilic Gold Nanoparticles: Structural and Cytotoxic Studies for Biomedical Applications.

Strongly hydrophilic gold nanoparticles (au nps), functionalized with citrate and l-cysteine, were synthetized and used as resveratrol (rsv) vehicle to improve its bioavailability.Two different conjugation procedures were investigated: the first by adding rsv during au nps synthesis (1) and the second by adding rsv after au nps synthesis (2).The two different conjugated systems, namely au nps@rsv1 and au nps@rsv2 respectively, showed good loading efficiency (η%): η1= 80 ± 5% for au nps@rsv1 and η2= 20 ± 3% for au nps@rsv2.Both conjugated systems were investigated by means of dynamic light scattering (dls), confirming hydrophilic behavior and nanodimension ( 1= 45 ± 12 nm and 2= 170 ± 30 nm).Fourier transform infrared spectroscopy (ft-ir), synchrotron radiation induced x-ray photoelectron spectroscopy (sr-xps) and near edge x-ray absorption fine structure (nexafs) techniques were applied to deeply understand the hooking mode of rsv on au nps surface in the two differently conjugated systems.Moreover, the biocompatibility of au nps and au nps@rsv1 was evaluated in the concentration range 1.0-45.5 μg/m l by assessing their effect on breast cancer cell vitality.The obtained data confirmed that, at the concentration used, au nps do not induce cell death, whereas au nps@rsv1 maintains the same anticancer effects as the unconjugated rsv.

Journal: Nanomaterials (Basel, Switzerland) (2020)
Publication types: Journal Article
Therapeutic plasma exchange in HELLP syndrome: A life savior.

Hellp (hemolysis, elevated liver enzymes, low platelet count) syndrome occurs in about 0.5%-0.9% of all pregnancies, but its prevalence is higher in patients with severe preeclampsia, accounting for a substantial maternal and perinatal morbidity and mortality.According to the latest american society for apheresis guidelines, therapeutic plasma exchange (tpe) performed for postpartum cases and antepartum hellp syndrome cases fall in categories iii and iv, respectively.Materials and methods retrospective analysis was done at our tertiary care center from january 2014 to june 2019 for patients diagnosed with hellp syndrome.Clinical data for age, gestational age at the time of diagnosis, type of delivery, outcome of pregnancy, history of preeclampsia /eclampsia, hemoglobin levels, ast, alt, ldh, platelet counts, prothrombin time, activated partial thromboplastin time, international normalised ratio, complete blood count, was obtained from patients' electronic medical records.The tpe was initiated within 24 hrs of diagnosis.All tpe was done on spectra optia apheresis system (terumo bct, inc, usa).Statistical testing was conducted with the statistical package for the social science system version spss 20.0 and r-3.2.0.Continuous variables were expressed as mean±sd and were compared between pre and post tpe records of patients by using the paired t test.Results nine patients fulfilled the criteria of hellp syndrome.Seven (77.8%) were diagnosed in the postpartum period and 2 (22.2%) during the second trimester.Out of the total nine patients, two patients (22.2%) recovered completely and were discharged on day 15 ± 7 days, whereas 4 (44.4%) patients were discharged on day 21 ± 7 days with the advice of hemodialysis.Two (22.2%) patients had an intrauterine death and were discharged 3-4 days after the demise.In all these patients (except one), the tpe was initiated within 24 h of the diagnosis.A significant increase in platelet count and decrease in the lactate dehydrogenase levels (p< 0.05) was observed post tpe.Conclusion our data showed that tpe improved the treatment outcome in patients with hellp syndrome despite being a category iii and iv indication among postpartum and antenatal females, respectively.However, a timely diagnosis and management are of paramount importance for a favorable outcome.Tpe needs to be performed within 24 h of the diagnosis postdelivery when the patient is not responsive to the usual therapies, especially in class i hellp syndrome.

Journal: Asian journal of transfusion science (2022)
Publication types: Journal Article
Right between the eyes: Corrugator muscle activity tracks the changing pleasantness of repeated slow stroking touch.

Subjective reports and physiological responses provide different appraisals of sensory input.The coherence between subjective and physiological responses to repeated pleasant stimuli remains largely unexplored, and is particularly important in situations where subjective responses are prone to cognitive or contextual bias.Here, we investigate how subjective and physiological responses to repeated gentle touch correspond at two separate sessions and compare these to responses obtained when smelling an odorant.Forty-eight participants underwent 60 trials of skin-to-skin slow stroking touch directed to the forearm.We collected subjective pleasantness reports, recorded facial electromyography (emg) of the corrugator and zygomaticus muscles and heart-rate variability (hrv).With increasing touch repetitions, mean ratings of pleasantness decreased and corrugator muscle activity increased during session 1, whereas zygomaticus activity remained largely unchanged during both sessions.Hrv was significantly higher during the first session, but did not increase from baseline during either sessions.Touch was rated as more pleasant than odor, and demonstrated greater resilience to satiety than the odor responses.Facial emg recordings of the corrugator muscle appear to be a relevant measure for capturing satiety effects in skin-to-skin touch.Zygomaticus and hrv responses were independent of the subjective appraisal of the gentle touch.Rather than being blueprints of the subjective reports, physiological responses appear to reflect different parts of the subjective experience.As such, an improved understanding of the subjective and physiological responses to pleasant stimuli may improve our understanding of the dynamic interactions that take place in shaping complex emotional phenomena, such as aversion and pleasantness.

Journal: Physiology & behavior (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Thinking outside the box: non-canonical targets in multiple sclerosis.

Multiple sclerosis (ms) is an immune-mediated disease of the central nervous system that causes demyelination, axonal degeneration and astrogliosis, resulting in progressive neurological disability.Fuelled by an evolving understanding of ms immunopathogenesis, the range of available immunotherapies for clinical use has expanded over the past two decades.However, ms remains an incurable disease and even targeted immunotherapies often fail to control insidious disease progression, indicating the need for new and exceptional therapeutic options beyond the established immunological landscape.In this review, we highlight such non-canonical targets in preclinical ms research with a focus on five highly promising areas: oligodendrocytes; the blood-brain barrier; metabolites and cellular metabolism; the coagulation system; and tolerance induction.Recent findings in these areas may guide the field towards novel targets for future therapeutic approaches in ms.

Journal: Nature reviews. Drug discovery (2022)
Publication types: Journal Article;Review
Timeliness of diagnosis of breast and cervical cancers and associated factors in low-income and middle-income countries: a scoping review.

S addressing the barriers to early breast and cervical cancer diagnosis in low and middle-income countries (lmics) requires a sound understanding and accurate assessment of diagnostic timeliness.This review aimed to map the current evidence on the time to breast and cervical cancer diagnosis and associated factors in lmics.Design scoping review.Sources medline (via pub med), cochrane library, scopus and cinahl.Eligibility criteria studies describing the time to diagnosis and associated factors in the context of breast and cervical cancer in lmics published from 1 january 2010 to 20 may 2021.Study selection and data synthesis two reviewers independently screened all abstracts and full texts using predefined inclusion criteria.The review was reported in accordance with the preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews.Evidence was narratively synthesised using predefined themes.Results twenty-six studies conducted across 24 lmics were included in the review, most (24/26) of which focused on breast cancer.Studies varied considerably in their conceptualisation and assessment of diagnostic time, events, intervals and delays, with a minority of the studies reporting the use of validated methods and tools.Patient-related intervals and delays were more frequently evaluated and reported than provider-related and health system-related intervals and delays.Across studies, there were variations in the estimated lengths of the appraisal, help-seeking, patient and diagnostic intervals for both cancers and the factors associated with them.Conclusions despite the significant burden of breast and cervical cancer in lmics, there is limited information on the timeliness of diagnosis of these cancers.Major limitations included variations in conceptualisation and assessment of diagnostic events and intervals.These underscore the need for the use of validated and standardised tools, to improve accuracy and translation of findings to better inform interventions for addressing diagnostic delays in lmics.

Journal: BMJ open (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review;Systematic Review