syedzayyan/paper_mill_benchmark huggingface dataset:
Role of Tocochromanols in Tolerance of Cereals to Biotic Stresses: Specific Focus on Pathogenic and Toxigenic Fungal Species.

Fungal pathogens capable of producing mycotoxins are one of the main threats to the cultivation of cereals and the safety of the harvested kernels.Improving the resistance of crops to fungal disease and accumulation of mycotoxins is therefore a crucial issue.Achieving this goal requires a deep understanding of plant defense mechanisms, most of them involving specialized metabolites.However, while numerous studies have addressed the contribution of phenylpropanoids and carotenoids to plant chemical defense, very few have dealt with tocochromanols.Tocochromanols, which encompass tocopherols and tocotrienols and constitute the vitamin e family, are widely distributed in cereal kernels; their biosynthetic pathway has been extensively studied with the aim to enrich plant oils and combat vitamin e deficiency in humans.Here we provide strong assumptions arguing in favor of an involvement of tocochromanols in plant-fungal pathogen interactions.These assumptions are based on both direct effects resulting from their capacity to scavenge reactive oxygen species, including lipid peroxyl radicals, on their potential to inhibit fungal growth and mycotoxin yield, and on more indirect effects mainly based on their role in plant protection against abiotic stresses.

Journal: International journal of molecular sciences (2022)
Publication types: Journal Article;Review
Exploring the lived return-to-work experience of individuals with acquired brain injury: use of vocational services and environmental, personal and injury-related influences.

To explore work outcomes, vocational services, barriers and facilitators for returning to work in individuals with acquired brain injury (abi) in queensland, australia and to identify areas for improvement.Design and methods ten semi-structured interviews were conducted with individuals with abi (stroke, traumatic brain injury, tumour).Interviews were analysed using a realist thematic analysis approach.Results participants either returned to the same work, different work, did not maintain work or did not have any work since their injury.Use of vocational services depended on participants' needs and insurance.Facilitators for return to work (rtw) were a supportive workplace and family, vocational rehabilitation that met the individual's needs, insurance coverage and self-motivation.Workplaces that were not understanding of brain injury, employment service providers who were unable to find work for participants, and physical and cognitive deficits were barriers to rtw.Workplaces, employment service providers and individuals require more information about the deficits associated with brain injury.Conclusions the use and effectiveness of vocational services were variable across participants and depended on insurance coverage and needs.Barriers and facilitators for rtw were affected by both the environment and the individual.Implications for vocational rehabilitation were identified.implications for rehabilitation a supportive workplace and family, and access to appropriate vocational rehabilitation are important environmental facilitators for rtw in individuals with abi.workplaces with a poor understanding of abi and employment service providers unable to find work for individuals with abi are environmental barriers to rtw.workplaces, employment service providers and individuals with abi require more information about the physical and cognitive deficits associated with abi.employment service providers need more training to develop comprehensive strategies to help individuals with abi find new employment.

Journal: Disability and rehabilitation (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Robotic resection of the uncinate process of the pancreas.

Since the development of the robotic platform, the number of robotic-assisted surgeries has significantly increased.Robotic surgery has gained growing acceptance in recent years, expanding to pancreatic resection.Here, we report a total robotic resection of the uncinate process of the pancreas performed in a patient with a cystic neuroendocrine tumor.To our knowledge, this is the first report of a robotic resection of the uncinate process of the pancreas.A 46-year-old man with no specific medical history was diagnosed with a neuroendocrine tumor after undergoing routine imaging.Biopsy guided by echoendoscopy revealed a well-differentiated neuroendocrine tumor.We decided to perform a robotic resection of the uncinate process of the pancreas after obtaining informed consent for the procedure.According to preoperative echoendoscopy and magnetic resonance imaging, there was a safe margin between the neoplasm and the main pancreatic duct.The technique uses five ports.The duodenum is fully mobilized, and kocher maneuver is carefully performed.The uncinate process of the pancreas is then identified.The resection of the uncinate process begins with the division of small arterial branches from the inferior pancreaticoduodenal artery in its inferior portion, followed by control of venous tributaries to the superior mesenteric vein.Intraoperative localization of the ampulla of vater is performed using indocyanine green enhanced fluorescence, thus defining the superior margin of the uncinate process.The pancreatic division is made about 5 mm below its upper margin for safety.Surgical specimen is then retrieved through the umbilical port inside a plastic bag.The raw pancreatic area is covered with hemostatic tissue and drained.The total operation time was 215 min.The docking time was 8 min and console time was 180 min.Blood loss was minimum, estimated at less than 50 m l.The postoperative period was uneventful, except for hyperamylasemia in the drain fluid.The patient was discharged on the 3rd postoperative day.The final pathological report confirmed well-differentiated pancreatic neuroendocrine tumor.Robotic resection of the uncinate process of the pancreas is safe and feasible, providing parenchymal conservation in a minimally invasive setting.Robotic resection should be considered for patients suffering from low-grade pancreatic neoplasms located in this part of the pancreas.

Journal: Journal of robotic surgery (2019)
Publication types: Case Reports;Journal Article
Squatting behavior during the COVID-19 pandemic: The case of the informal settlement "Los Hornos" in Buenos Aires.

The covid-19 outbreak magnified territorial inequalities and increased vulnerability among low-income groups.Inhabitants in informal settlements are structurally disadvantaged in coping with communicative diseases such as the covid-19 pandemic.Despite that, the pandemic has been accompanied by the proliferation of informal settlements.This study explores how the pandemic caused the squatting on new land with the case of "los hornos" in suburban buenos aires.We used a random forest algorithm and google earth engine to estimate the rapid growth of a new informal settlement from a series of satellite images from early 2020.We also conducted semi-structured interviews with inhabitants to investigate the link between squatting and covid-19.The study revealed that squatting on new land during the pandemic was mainly due to economic difficulties, overcrowding in existing informal settlements in the metropolitan center, and speculation in the informal housing market.This case is an example of how the most vulnerable groups bore the brunt of the pandemic, how the households in the existing informal settlement were behaving similar to those in the formal housing market (i.e., away from the urban centers), and how the outbreak had also been an opportunity for collective action of squatting a new land to materialize.

Journal: Habitat international (2022)
Publication types: Journal Article
COVID-19 Associated Contact Restrictions in Germany: Marked Decline in Children's Outpatient Visits for Infectious Diseases without Increasing Visits for Mental Health Disorders.

Children have a low risk for severe covid-19 infections, but indirect consequences of the pandemic may affect their health.We evaluated nationwide data on children's outpatient visits before and during the first wave of the covid-19 pandemic in germany.Data from the national association of statutory health insurance physicians for all children with statutory health insurance and at least one physician's office visit between january 2019 and june 2020 were evaluated for total visits and selected diagnoses for the 2nd quarter of 2019 (8.29 million children, controls) and the 2nd quarter of 2020 (8.5 million, pandemic).Outpatient visits per child fell by 18% during the first wave of the pandemic.Outpatient visits associated with diagnosed infections fell markedly by 51%, particularly for children up to age 5 years for gastroenteritis (73%), otitis media (71%), and streptococcal angina (78%).Outpatient visits for diagnosed chronic physical disorders (diabetes, celiac disease, and hay fever) and mental and behavioral disorders showed little change.Reduced contact between children appears to markedly reduce infection transmission.Infection risks in educational settings should be attenuated after the pandemic through targeted education and counseling and appropriate relationship prevention measures to improve quality of life and opportunities for children and to reduce stress and lost work time for parents.

Journal: Children (Basel, Switzerland) (2021)
Publication types: Journal Article
In vitro and in vivo pharmacological evaluation of the synthetic cannabinoid receptor agonist EG-018.

Synthetic cannabinoid receptor agonists (scras) possess high abuse liability and complex toxicological profiles, making them serious threats to public health.Eg-018 is a scra that has been detected in both illicit products and human samples, but it has received little attention to date.The current studies investigated eg-018 at human cb1and cb2receptors expressed in hek293 cells in [3h]cp55,940 competition binding, [35s]gtpγs binding and forskolin-stimulated c amp production.Eg-018 was also tested in vivo for its ability to produce cannabimimetic and abuse-related effects in the cannabinoid tetrad and thc drug discrimination, respectively.Eg-018 exhibited high affinity at cb1(21 n m) and at cb2(7 n m), but in contrast to typical scras, behaved as a weak partial agonist in [35s]gtpγs binding, exhibiting lower efficacy but greater potency, than that of thc at cb1and similar potency and efficacy at cb2.Eg-018 inhibited forskolin-stimulated c amp with similar efficacy but lower potency, compared to thc, which was likely due to high receptor density facilitating saturation of this signaling pathway.In mice, eg-018 (100 mg/kg, 30 min) administered intraperitoneally (i.p.) did not produce effects in the tetrad or drug discrimination nor did it shift thc's ed50value in drug discrimination when administered before thc, suggesting eg-018 has negligible occupancy of brain cb1receptors following i.p.Administration.Following intravenous (i.v.) administration, eg-018 (56 mg/kg) produced hypomotility, catalepsy, and hypothermia, but only catalepsy was blocked by the selective cb1antagonist rimonabant (3 mg/kg, i.v.).Additional studies of eg-018 and its structural analogues could provide further insight into how cannabinoids exert efficacy through the cannabinoid receptors.

Journal: Pharmacology, biochemistry, and behavior (2020)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't;Research Support, U.S. Gov't, Non-P.H.S.
BENEFIT AND SAFETY OF INCOBOTULINUMTOXINA FOR EARLY MANAGEMENT OF POST-STROKE SPASTICITY IN A PATIENT WITH SARS-COV-2: A CASE REPORT.

To describe a case of early management of post-stroke spasticity treated with incobotulinumtoxin a (inco a) in a patient with sars-co v-2 (covid-19).Scarce information is available on this subject, as the covid-19 pandemic has necessitated postponement of interventions in infected and clinically suspicious patients.Case report a 58-year-old woman presenting with ischaemic stroke, was infected with sars-co v-2 virus due to nosocomial contact.Despite clinical improvement, the patient developed early spasticity.Modified ashworth scale (mas) was grade ii in her left elbow, wrist flexors and left gastrocnemius.Inco a was injected, using ultrasound guidance, in her upper and lower limbs.No complications were reported after the procedure.Two weeks afterwards, there was an improvement in her motor balance and spasticity, mas was graded i in the left elbow, wrist flexors, and ii in the left gastrocnemius.At 12 weeks, the patient reported improvement at a global level, with increasing independence and functionality.Conclusion this case indicates the benefits and safety of inco a for early treatment of post-stroke spasticity in a patient with confirmed sars-co v-2.Despite the current status of national healthcare systems due to the covid-19 pandemic, increased efforts should be made to avoid discontinuation of treatment for spasticity.

Journal: Journal of rehabilitation medicine. Clinical communications (2021)
Publication types: Case Reports;Journal Article
Effect of renal function under left ventricular assist device support on the cardiac function and clinical events after heart transplantation.

We investigated the effects of pre-transplantation renal dysfunction under left ventricular assisted device (lvad) support on post-transplantation cardiac function, and patient prognosis after heart transplantation (htx).Method all patients who were bridged by lvad and underwent htx at our hospital between 2007 and 2022 were included in this study.Patients were classified into two groups based on estimated glomerular filtration rate (e gfr) before htx: renal dysfunction (rd) group (e gfr < 60 m l/min/1.73 m2) and non-renal dysfunction (nrd) group.Result a total of 132 patients were analyzed, of whom 48 were classified into the rd group and 84 into the nrd group (rd group, 47.9 ± 10.1 years; nrd group, 38.4 ± 11.9 years, p < .0001).Under lvad support before htx, the rd group tended to have a history of right ventricular failure (rd group, nine (19%); nrd group, seven (8%); p = .098).After htx, the echocardiographic parameters did not differ between the two groups in the long term.Furthermore, more concise hemodynamic parameters, exemplified by right heart catheterization, were not significantly different between the two groups.Regarding graft rejection, no significant differences were found in acute cellular rejection and cardiac allograft vasculopathy following htx.In contrast, patients with rd before htx had significantly increased mortality in the chronic phase after htx and initiation of maintenance dialysis, without any overt changes in cardiac function.Conclusion pre-transplantation renal dysfunction under lvad support significantly affected clinical course after htx without any overt changes in graft cardiac function.

Journal: Clinical transplantation (2023)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Association of depression symptom severity with short-term risk of an initial hospital encounter in adults with major depressive disorder.

Despite the availability of pharmacologic and nonpharmacologic treatment options, depression continues to be one of the leading causes of disability worldwide.This study evaluated whether depression symptom severity, as measured by phq-9 score, of patients diagnosed with mdd is associated with short-term risk of a hospital encounter (er visit or inpatient stay).Methods adults with ≥1 phq-9 assessment in an outpatient setting (index date) and ≥ 1 mdd diagnosis within 6 months prior were included from the de-identified optum electronic health record database (april 2016-june 2019).Patients were categorized by depression symptom severity based on phq-9 scores obtained by natural language processing.Crude rates, adjusted absolute risks, and adjusted relative risks of all-cause and mdd-related hospital encounters within 30 days following assessment of depression severity were determined.Results the study population consisted of 280,145 patients with mdd and ≥ 1 phq-9 assessment in an outpatient setting.Based on phq-9 scores, 26.9% of patients were categorized as having none/minimal depression symptom severity, 16.4% as mild, 24.7% as moderate, 19.6% as moderately severe, and 12.5% as severe.Among patients with none/minimal, mild, moderate, moderately severe, and severe depression, the adjusted absolute short-term risks of an initial all-cause hospital encounter were 4.1, 4.4, 4.8, 5.6, and 6.5%, respectively; mdd-related hospital encounter adjusted absolute risks were 0.8, 1.0, 1.3, 1.6, and 2.1%, respectively.Compared to patients with none/minimal depression symptom severity, the adjusted relative risks of an all-cause hospital encounter were 1.60 (95% ci 1.50-1.70) for those with severe, 1.36 (1.29-1.44) for those with moderately severe, 1.18 (1.12-1.25) for those with moderate, and 1.07 (1.00-1.13) for those with mild depression symptom severity.Conclusions these study findings indicate that depression symptom severity is a key driver of short-term risk of hospital encounters, emphasizing the need for timely interventions that can ameliorate depression symptom severity.

Journal: BMC psychiatry (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Maternal bisphenol A and triclosan exposure and allergic diseases in childhood: a meta-analysis of cohort studies.

Bisphenol a (bpa) and triclosan (tcs) are both endocrine-disrupting chemicals (edcs), and pregnant women are usually exposed to them through daily consumption.This study aimed to explore the relationship between prenatal bpa and tcs exposure and allergic diseases in childhood by systematic review and meta-analysis.We searched the topic of prenatal bpa and tcs exposure and allergic diseases in childhood published before march 22, 2021, in four databases, including pub med, web of science, embase, and cochrane.Statistical analysis was completed using stata software (version 16.0).Seven papers on bpa and four papers on tcs were included in this meta-analysis.The association between prenatal exposure to bpa and total allergic diseases in childhood showed a pooled effect estimate of 1.13 (95% ci, 1.04, 1.23), with i2= 0.0% (p = 0.615).The effect estimates between bpa exposure and each allergic disease were 1.18 (95% ci, 1.02, 1.36) for wheezing, 1.23 (95% ci, 1.01, 1.50) for asthma, 1.03 (95% ci, 0.89, 1.18) for eczema/rashes or hives, and 1.19 (95% ci, 0.91, 1.56) for aeroallergies.Prenatal exposure to tcs had no association with the four types of allergic disease in childhood.Bpa exposure during the prenatal period was positively associated with allergic disease in childhood.Strengthening prenatal edc exposure control is necessary for child health.

Journal: Environmental science and pollution research international (2022)
Publication types: Meta-Analysis;Journal Article
High resolution anorectal manometry in patients with anorectal dysfunctions and the therapeutic consequences.

Introduction high resolution anorectal manometry (hram) is a diagnostic method indicated in patients with anorectal dysfunction.The aim of the study was to evaluate the prevalence of anorectal dysfunctions and to assess therapeutic consequences.Methods retrospective data of consecutive patients referred to hram in the period from march 2019 to february 2021 were evaluated.Basic manometric parameters were assessed: resting pressure (rp), maximal squeeze pressure (sp), rectal sensitivity (rs), and dyssynergic defecation (dd).Results 113 patients with combined fecal incontinence and obstructive defecation syndrome (fi + ods: 44.2%), fecal incontinence (fi: 26.5%), obstructive defecation syndrome (ods: 16.8 %), stoma before restoration of intestinal continuity (6.2%), functional pelvic pain (fp: 3.5 %) and controversial cases (2.7%) were analyzed.The average age was 54 years; female patients predominated (72 %).Patients with fi and fi+ods had lower mean rp (57 mm hg and 53 mm hg) and/or lower sp (160 mm hg and 140 mm hg) compared to baseline.Patients with ods had normal values of mean rp (75 mm hg) and sp (225 mm hg).Dd was noted in most patients (fi: 76.6%, fi + ods: 88%, ods: 89.5%, fp: 100%).Conservative therapy with pelvic floor physiotherapy was provided in most cases (fi+ods: 40%, ods: 36.8%, fi: 13.3%, fp: 75%).Conclusion in patients with defecation disorders there is a high prevalence of pathological manometric findings that combine with each other.Based on manometric findings, conservative treatment with individual pelvic floor physiotherapy can be initiated.

Journal: Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti (2022)
Publication types: Journal Article
Resolution of iron deficiency following successful eradication of Helicobacter pylori in children.

To assess correlation between successful helicobacter pylori (hp) eradication and resolution of iron deficiency in children, without iron supplementation.Methods medical records of children diagnosed with hp infection based on endoscopy were retrospectively reviewed.Among those with non-anaemic iron deficiency (naid) or iron deficiency anaemia (ida), haemoglobin, ferritin and crp levels were compared prior and 6-9 months' post-successful hp eradication.Predictors of resolution of iron deficiency following hp eradication were assessed.Results among 60 included children (median age 14.8, iqr12.3-16 years; 62% males), 35% had ida while the remaining 65% had naid.Following successful hp eradication, iron normalised in 60% of patients with iron deficiency (id), without iron supplementation.There were significant improvements in haemoglobin and ferritin concentrations following hp eradication with haemoglobin increasing from 12.3 g/d l to 13.0 g/d l and ferritin increasing from 6.3 μg/l to 15.1 μg/l (p < 0.001).In multiple logistic regression, older age was the only factor associated with resolution of anaemia following hp eradication (or 1.65, 95% ci 1.16-2.35, p = 0.005).Conclusion successful hp eradication could be helpful in improving iron status among children with refractory naid or ida.Older age may predict this outcome.Screening for hp might be considered in the workup of refractory ida or id.

Journal: Acta paediatrica (Oslo, Norway : 1992) (2022)
Publication types: Journal Article
Use of topical anti-inflammatory and antineoplastic agents in the treatment of young-aged actinic cheilitis: A systematic review.

Introduction several treatments have been used to reduce inflammation and to reverse epithelial alterations in actinic cheilitis (ac).Aim a systematic review was conducted to analyze the potential of topical treatments for remission and clinical improvement of ac as well as patient acceptability.Methods a systematic review of clinical trials was conducted following the pico strategy to answer the following question: are topical anti-inflammatory and antineoplastic agents effective in the treatment of actinic cheilitis?The quality of the studies was assessed by rob-2, and the certainty of evidence was rated by grade guidelines.Results eight clinical trials were selected, including four that investigated the use of anti-inflammatory drugs and four use of antineoplastic agents.The use of 3% diclofenac sodium was associated with partial remission of ac, while 5% imiquimod and ingenol mebutate promoted complete remission.Furthermore, 5% fluorouracil was the drug most associated with complications during treatment.Diclofenac sodium (3%) and fludroxycortide showed the best acceptance by the patients, especially in terms of symptom relief and comfort provided.Conclusion the anti-inflammatory and antineoplastic agents analyzed largely provided good clinical outcomes, with evidence of remission of ac lesions, development of few local adverse reactions during treatment, and good patient adherence.

Journal: Journal of cosmetic dermatology (2022)
Publication types: Journal Article;Systematic Review