syedzayyan/paper_mill_benchmark huggingface dataset:
Rehabilitation of Post-Stroke Swallowing Dysfunction with Repeated Transcranial Magnetic Stimulation RTMS Based on Tomographic Images

In order to study the rehabilitation of dysphagia after stroke, this paper uses tomographic imaging technology and repeated transcranial magnetic stimulation r tms therapy to verify the effect of this treatment method on the rehabilitation of dysphagia after stroke.In this study, the method of systematic review and meta‐analysis are used to comprehensively collect the current published literature on the application of repeated transcranial magnetic stimulation in post‐stroke dysphagia, and to quantitatively synthesize and qualitatively analyze the data and opinions.This article aims to explore the therapeutic effect and mechanism of repeated transcranial magnetic stimulation in the treatment of dysphagia after stroke, and to evaluate its effectiveness, so as to better guide the application of repetitive transcranial magnetic stimulation in the rehabilitation of dysphagia after stroke.The evaluation methods of r tms for the clinical efficacy of pas, fds, vds, doss, dd, and bi in patients with dysphagia after stroke are consistent.The influencing factors of r tms on the swallowing function impairment of stroke include the choice of stimulation frequency, stimulation site, and stimulation time.Low‐frequency stimulation of the contralateral hemisphere and high‐frequency stimulation of the affected brain can reduce the excitability of the contralateral brain and enhance the excitability of the affected brain.The stimulation site is mainly in the pharyngeal cortex.Experiments show that r tms can improve swallowing dysfunction after stroke within 2 weeks, and r tms has no obvious side effects on swallowing dysfunction in patients with cerebral infarction.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Meta-Analysis;
Refractive Errors and Risk Factors for Myopia in Primary School Students in Urumqi

To investigate the prevalence of refractive errors and risk factors for myopia in primary school students in saybag district of urumqi.Methods.A total of 972 primary school students in two elementary schools in saybag district were included in this study which was conducted from june 2019 to november 2019.Uncorrected visual acuity test and noncycloplegic autorefraction were performed, and their visual acuity was analyzed.Multivariate regression analysis was performed to predict risk factors for myopia.Results.Myopia was the most frequent refractive error among primary school students aged 7-11 in sayibake district, urumqi city, with a prevalence rate of 60.39%, and mainly mild myopia.The proportion of myopia increased with age, and the proportion of females suffering from myopia was higher than that of males, and the proportion of students from the han ethnic group suffering from myopia was also higher than that of the other ethnic groups.The students mainly suffered from mild myopia, and the degree of myopia was related to age and gender, regardless of ethnicity.In addition, multivariate regression analysis showed that age and gender were the influencing factors of myopia occurrence and progression conclusion.our study results showed a significant prevalence of myopia in pupils aged 7-11 years in saybag district of urumqi is affected by gender and age and not by ethnicity.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
QoS-Aware Smart Phone-Based User Tracking Application to Prevent Outbreak of COVID-19 in Saudi Arabia

Diverse variants of covid-19 are repeatedly making everyday living unstable.In reality, the conclusive retort of this highly contagious virus still is in incognito mode.The health experts’ primary guideline on the possible prevention of this disease outbreak, including a list of restrictions and confinements, is insufficient in case of any public congregation.As a result, the demand for precise and upgraded real-time covid-19 tracking and prevention-based applications increases.However, most of the existing android-based applications face a lack of data security and reliability that cannot satisfy the additional quality of service (qo s) requirements.This paper proposes an easy-to-operate android-based multifunctional application to track individuals’ health situations, allow uploading scanning report by the authorized organization like universities, mosques, school, and hospitals and helps the users to maintain guidelines via manageable steps.This article offers a three-layered qo s aware service-oriented task scheduling model upon multitasking android-based frontend focusing the cognitive-based ai applications in healthcare with a continual learning paradigm.Designed model is competent to optimize heterogeneous service scheduling and can minimize data delivery time, as well as the resource cost.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Protocatechualdehyde Inhibits the Osteoclast Differentiation of RAW264.7 and BMM Cells by Regulating NF- κ B and MAPK Activity

Protocatechualdehyde (pca), an important component of salvia miltiorrhiza , has many activities, such as anti‐inflammatory and antisepsis activities.However, the role of pca in osteoclasts is not clear.We used raw264.7 cells (a mouse leukemic monocyte/macrophage cell line) and bone marrow macrophages (bmms) to probe the role of pca in osteoclasts and the underlying mechanism.The effects of pca on cell activity were evaluated with cck‐8 assays.Trap staining detected mature osteoclasts.Corning osteo assay surface plates were used to examine absorption.The levels of rna and protein were analyzed, respectively, using rt‐pcr and western blotting.Pca (5 μ g/ml) was not toxic to the two cell types but reduced the formation of osteoclasts and bone absorption.Furthermore, pca restrained the expression of m rnas encoding proteins associated with osteoclasts and reduced the phosphorylation of proteins in important signaling pathways.The results indicate that pca inhibits osteoclast differentiation by suppressing nf‐ κ b and mapk activity.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Prognostic and Immunological Significance of FUNDC1 in Hepatocellular Carcinoma: A Study on TCGA Mining

Hepatocellular carcinoma (hcc) is an inflammation-related malignancy influenced by the immune microenvironment, such as immune tolerance and evasion.Hfun14 domain-with protein 1 (fundc1) is a necessary mitochondrial outer membrane protein, functioning as a receptor for hypoxia-caused mitophagy, which is related to human immunity.The relationship between hcc and fundc1 in terms of prognosis and immunology was demonstrated in the current investigation.Even so, the function of fundc1 in liver cancer is yet unknown.Methods.The cancer genome atlas (tcga) and gene expression omnibus (geo) datasets were utilized for examining if fundc1 expression is associated with clinicopathological characteristics and prognosis.Genetic changes (mutation), dna methylation, and their relationship with patient prognosis were identified by c bio portal and meth surv.Utilizing the tumor immune estimation resource (timer), immune checkpoints, infiltration, and immune cell biomarkers were analyzed.Utilizing the string database, the network of protein-protein interactions was created.Using gene set enrichment analysis, the fundc1 biological roles were determined (gsea).Results.Fundc1 elevation was significantly linked with gender ( p &lt; 0.001 ), tumor stage ( p = 0.01349 ), tumor grade ( p &lt; 0.001 ), and alpha-fetoprotein (afp) ( p &lt; 0.001 ) levels in hcc.It was illustrated by roc curve analysis that fundc1 had a significant diagnostic and prognostic value.The fundc1 genetic change rate was 0.6%.Four out of 6 dna methylation cp g sites were associated with the hcc prognosis.Fundc1 is associated strongly with immune cell infiltration in hcc.Moreover, fundc1 was positively related to immune checkpoints such as mutant-allele tumor heterogeneity (math) ( p &lt; 0.001 ), ploidy ( p &lt; 0.05 ), homologous recombination defect (hrd) ( p &lt; 0.001 ), and loss of heterozygosity (loh).Gsea revealed significant fundc1 enrichment in the cell cycle, hedgehog, and mapk signaling pathways.Conclusion.Fundc1 is a mitophagy regulator that could be a therapeutic, prognostic, and putative diagnostic biomarker for hcc.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Profound Effect of Pulmonary Surfactant on the Treatment of Preterm Infants with Respiratory Distress Syndrome

Inherited diseases caused by dysfunction of pulmonary surfactant metabolism or surfactant dysfunction have recently been considered the underlying causes of neonatal and pediatric respiratory diseases.Respiratory distress syndrome in premature infants is a common respiratory disease in pediatrics.It is caused by underdeveloped lungs in infants and a lack of active substances on the surface of the alveoli, which leads to insufficiency of lung function, which can lead to difficulty breathing, increased heart rate, facial bruising, and more.Neonatal respiratory distress syndrome is a very dangerous disease with a high mortality rate and a great threat to children’s lives and health.Therefore, enough attention and treatment should be caused in clinical practice.Natural pulmonary surfactant (ps) has achieved positive effects in the treatment of neonatal respiratory distress syndrome (rds), reducing neonatal mortality, the application of mechanical ventilation, and the occurrence of late complications.To further explore the role of pulmonary surfactants in the treatment of neonatal respiratory distress syndrome, to analyze the best time to use ps to prevent rds, this paper has selected premature infants with rds received by the neonatal department of a hospital in a province from march 2019 to october 2020 to compare the efficacy of pulmonary surfactant (ps) in preterm infants with respiratory distress syndrome (rds).The experiment has found that the average mechanical ventilation time (5.1 d) and oxygen therapy time (7.3 d) in the early group are shorter than the average mechanical ventilation time (6.4 d) and oxygen therapy time (10.6 d) in the late group.It has been demonstrated that early administration of pulmonary surfactant (ps) therapy is of great help in improving respiratory distress syndrome in premature infants.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
PRL/PRLR Can Promote Insulin Resistance by Activating the JAK2/STAT5 Signaling Pathway

Although prolactin (prl) is known to affect food intake, weight gain, and insulin resistance, its effects on lipid metabolism and underlying mechanisms remain underinvestigated.This study aimed to investigate the effects of prl and its receptor (prlr) on fat metabolism in regulating the jak2/stat5 signaling pathway.Methods.Sw872 adipocytes were incubated with oleic acid to establish an insulin resistance (ir) model.Western blot was used to detect the expression of prlr, jak2, p-jak2, stat5, and p-stat5.Triglyceride (tg) mass was detected by chemical colorimetry methods.Results.Fat droplets in the high-dose and medium-dose prl groups were significantly higher than in the ir model group.Tg mass in the cells was increased significantly compared with the model group.Compared with the control group, the expression of prlr, p-jak2, and p-stat5 were significantly decreased in the ir model group when prl was intervened for 24 h and 48 h.The expression of prlr, p-jak2, and p-stat5 in the high-dose prl intervention group increased significantly compared with the model group.The prlr overexpressing group had significantly increased tg content and prlr, and jak2, p-jak2, stat5, and p-stat5 levels compared with the ir model.Conclusion.Prl and prlr are related to fat metabolism, and the prl/prlr signaling pathway can promote insulin resistance by activating the jak2/stat5 signaling pathway and increasing the deposition of tgs.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Prevalence of Refractive Error in School Children in Suining City of Sichuan Province, China: A School-Based Cross-Sectional Study

To investigate the prevalence of refractive errors among school children in suining city, sichuan province, and to provide a scientific basis for prevention and control of myopia.Methods.This was a school-based cross-sectional study.Children aged 6-15 years were selected from kindergartens, primary schools, and middle schools in the urban setting of suining city.The children underwent ocular examination including measurement of uncorrected visual acuity (ucva), visual acuity when wearing glasses, and noncycloplegic autorefractometry.Results.Of the 1200 eligible students, 1138 children (94.8%), 553 of them girls (47.4%), participated.The mean age was 10.64 ± 2.89 years.The prevalence of myopia, hyperopia, astigmatism, and emmetropia was 59.1% (95% confidence interval (ci): 57.6, 60.5), 5.0% (95% ci: 4.7, 6.1), 38.4% (95% ci: 55.5, 58.5), and 25% (95% ci: 23.7, 26.2), respectively.In univariate analysis, the prevalence of myopia was correlated with age, female gender, and learning stage.The prevalence of hyperopia and astigmatism was correlated with age and learning stage.The prevalence of mild myopia, moderate myopia, and high myopia in the 1138 students was 17.7%, 41.4%, and 3.3%, respectively.The prevalence of mild, moderate, and high myopia all increased with age and learning stage.The prevalence of myopia differed by gender.The mean spherical equivalents of the right and left eyes were − 1.40 ± 1.99 diopters (d) and − 1.29 ± 1.93 d , respectively, and the median values were -0.75 d and -0.6 d, respectively.The mean spherical equivalent increased with age, learning stage, and female gender.Conclusions.The most common type of refractive error was myopia which was associated with higher age, female gender, and higher learning stage.This study provides new data and recommendations for myopia-control in school-aged children in sichuan province.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Presepsin Predicts Severity and Secondary Bacterial Infection in COVID-19 by Bioinformatics Analysis

Introduction.Novel coronavirus pneumonia (covid-19) is an acute respiratory disease caused by the novel coronavirus sars-co v-2.Severe and critical illness, especially secondary bacterial infection (sbi) cases, accounts for the vast majority of covid-19-related deaths.However, the relevant biological indicators of covid-19 and sbi are still unclear, which significantly limits the timely diagnosis and treatment.Methods.The differentially expressed genes (degs) between severe covid-19 patients with sbi and without sbi were screened through the analysis of gse168017 and gse168018 datasets.By performing gene ontology (go) enrichment analysis for significant degs, significant biological processes, cellular components, and molecular functions were selected.To understand the high-level functions and utilities of the biological system, the kyoto encyclopedia of genes and genomes (kegg) pathway enrichment analysis was performed.By analyzing protein-protein interaction (ppi) and key subnetworks, the core degs were found.Results.85 degs were upregulated, and 436 degs were downregulated.The cd14 expression was significantly increased in the sbi group of severe covid-19 patients ( p &lt; 0.01 ).The area under the curve (auc) of cd14 in the sbi group in severe covid-19 patients was 0.9429.The presepsin expression was significantly higher in moderate to severe covid-19 patients ( p &lt; 0.05 ).Presepsin has a diagnostic value for moderate to severe covid-19 with the auc of 0.9732.The presepsin expression of covid-19 patients in the nonsurvivors was significantly higher than that in the survivors ( p &lt; 0.05 ).Conclusion.Presepsin predicts severity and sbi in covid-19 and may be associated with prognosis in covid-19.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Preoperative Nutritional Status and Risk Factors Associated with Delayed Discharge in Geriatric Patients Undergoing Gastrectomy: A Single-Center Retrospective Study

Preoperative malnutrition is an independent risk factor for postoperative complications and survival for gastric cancer patients.The study is aimed at investigating the prevalence of malnutrition, perioperative nutritional support, and the risk factors associated with delayed discharge of geriatric patients undergoing gastrectomy.Methods.A retrospective study of gastric cancer patients ( age ≥ 65 ) who underwent gastrectomy at zhongshan hospital from january 2018 to may 2020 was conducted.Clinical data, including demographic information, medical history, surgery-related factors, and perioperative nutritional management, were collected and analyzed.Postoperative complications were assessed according to the clavien-dindo grading system, and the prognostic nutritional index (pni) was calculated.The risk factors affecting the prolongation of postoperative hospital stay were analyzed.Results.A total of 783 patients were reviewed.The overall frequency of malnutrition was 31.3% (249/783).The albumin, prealbumin, and hemoglobin levels were lower in the malnutrition group than in the well-nourished group.The proportion of patients who received preoperative total parenteral nutritional support in the malnutrition group was significantly higher than in the well-nourished group (12.4% vs.3.7%, p &lt; 0.001 ).All patients received postoperative parenteral nutrition (pn); the proportion of patients who received total nutrient admixture (tna) in the malnutrition group was lower than in the well-nourished group (22.1% vs.33.5%, p = 0.001 ).No significant difference was found in the duration of postoperative nutrition between groups ( p &gt; 0.05 ).The malnutrition group was associated with a higher rate of postoperative complications ( p &lt; 0.001 ).Univariate and multivariate regressions revealed that age &gt; 70 years ( or = 1.216 , 95% ci 1.048-1.411, p = 0.010 ), operation time &gt; 180 min ( or = 1.431 , 95% ci 1.237-1.656, p &lt; 0.001 ), pni &lt; 44.5 ( or = 1.792 , 95% ci 1.058-3.032, p = 0.030 ), and postoperative complications ( or = 2.191 , 95% ci 1.604-2.991, p &lt; 0.001 ) were significant risk factors associated with delayed discharge.Conclusion.Malnutrition is relatively common in elderly patients undergoing gastrectomy.Advanced age, duration of surgery, lower levels of pni, and postoperative complications were risk factors associated with delay discharge.Elderly gastric cancer patients with risk factors urgently require specific attention for reducing hospital stay.

Journal: Applied Bionics and Biomechanics (2022)
Publication types: Research Article;
Prediction of Risk Takers in Arterial Hypertension Patients with Data Mining Application

Hyper arterial pressure (hap) is a disease that kills silently because it does not produce symptoms in the early stages, making it difficult to diagnose.When it is detected, its treatment is not accessible to everyone, which affects the disease’s long-term development.Hypertension affects a large portion of the iraqi population.In the current research paper, we have discussed how data mining can be applied to identify the status of the risk factors that affect arterial hypertension due to i10-i15 causes, evaluating the context variables disability, overwork, high-risk pregnancy, stress, high diets, and poor nutrition in the population between 50 and 64 years in the city of baghdad.It is possible to see how data mining in large volumes of health data can generate new knowledge and thus uncover hidden patterns in the data through the development of this research.Attributes directly linked to disease prevalence can be found in data from baghdad, iraq, even if they are not directly linked to a specific cause.This shows that some variables are transversal to the development of the disease regardless of its categorization.Cluster analysis revealed that, even though these diseases are categorized as having different causes, they have a degree of incorrect classification of 40.71% because they present attributes with a similar behavior transversal to the disease and not the disease-specific cause for which it is categorized.

Journal: Wireless Communications and Mobile Computing (2022)
Publication types: Research Article;
Prediction of Functional Genes in Primary Varicose Great Saphenous Veins Using the lncRNA-miRNA-mRNA Network

Long noncoding rnas (lnc rnas) have been widely suggested to bind with the micro rna (mi rna) sites and play roles of competing endogenous rnas (ce rnas), which can thus affect and regulate target gene and m rna expression.Such lnc rna-related ce rnas are identified to exert vital parts in vascular disease.Nonetheless, it remains unknown about how the lnc rna-mi rna-m rna network functions in the varicose great saphenous veins.Methods.This study acquired the lnc rna and m rna expression patterns from the geo database and identifies the differentially expressed m rnas and lnc rnas by adopting the r software “limma” package.Then, mi rcode, mi rdb, mi rtarbase, and target scan were used to establish the mi rna-m rna pairs and lnc rna-mi rna pairs.In addition, the lnc rna-mi rna-m rna ce rna network was constructed by using cytoscape.Protein-protein interaction, gene ontology functional annotations, and kyoto encyclopedia of genes and genomes enrichment were carried out to examine the candidate hub genes, the functions of genes, and the corresponding pathways.Results.In line with the preset theory, we constructed ce rna network comprising 12 lnc rnas, 38 mi rnas, and 149 m rnas.Kyoto encyclopedia of genes and genomes analysis indicated that the pi3k/akt signaling pathway played a vital part in the development of varicose great saphenous veins.Ac114730, ac002127, and ac073342 were significant biomarkers.At the same time, we predicted the potential mi rna, which may exert a significant influence on the varicose great saphenous veins, namely, mi r-17-5p, mi r-129-5p, mi r-1297, mi r-20b-5p, and mi r-33a-3p.Conclusion.By performing ce rna network analysis, our study detects new lnc rnas, mi rnas, and m rnas, which can be applied as underlying biomarkers of varicose great saphenous veins and as therapeutic targets for the treatment of varicose great saphenous veins.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;