syedzayyan/paper_mill_benchmark huggingface dataset:
Clinical Value of sTREM-1, PCT, and 1,3-β-D Glucan in Diagnosis of Immune-Associated Pulmonary Interstitial Disease with Fungal Infection

Fungal infection in the lungs can cause fungal infectious diseases.This disease develops rapidly and involves a wide range.Pathogenic fungi are also more serious types of pathogenic bacteria.If it invades deep organs and tissues, it will endanger life, so it needs timely diagnosis.Aim .To investigate the diagnostic value of serum soluble myeloid cell triggering receptor‐1 (s trem‐1), procalcitonin (pct), and 1,3‐ β ‐d glucan detection in immune related lung disease complicated with fungal infection.Methods .In this study, a case‐control study was conducted.50 patients with immune‐related pulmonary disease complicated with fungal infection (infection group) diagnosed by sputum culture in our hospital from january 2017 to december 2021 were selected as the control group, and 50 patients with immune‐related pulmonary disease without fungal infection were selected as the control group.The levels of s trem‐1, pct, and 1,3‐ β ‐d glucan were compared in the two groups.The receiver operating characteristic (roc) was used to analyze the value of the three indicators in the diagnosis of immune‐related pulmonary disease complicated with fungal infection, and the changes of the three indicators before and after treatment were compared.Results .The levels of s trem‐1, pct, and 1,3‐ β ‐d glucan in the infection group were higher than those in the control group ( p &lt; 0.05).The levels of s trem‐1, pct, and 1,3‐ β ‐d glucan in the infection group after treatment were significantly lower than those before treatment ( p &lt; 0.05).The auc value of s trem‐1 in the diagnosis of immune‐related pulmonary diseases complicated with fungal infection was 0.980, the sensitivity was 97.11%, and the specificity was 83.06%.The auc value of pct in the diagnosis of immune‐related pulmonary diseases complicated with fungal infection was 0.860, the sensitivity was 80.00%, and the specificity was 72.41%.The auc value of 1,3‐ β ‐d glucan in the diagnosis of immune‐related pulmonary diseases complicated with fungal infection was 0.993, the sensitivity was 98.74%, and the specificity was 99.16%.The levels of s trem‐1, pct, and 1,3‐ β ‐d glucan in the infection group after treatment were considerably lower than those before treatment, and the difference was statistically significant ( p &lt; 0.05).Conclusion .The detection of s trem‐1, pct, and 1,3‐ β ‐d glucan levels has high clinical value for the diagnosis of immune‐related pulmonary diseases complicated with fungal infection.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Clinical Observation and Value Analysis of Endovascular Interventional Therapy for Intracranial Venous Sinus Thrombosis

The main aim of this study was to investigate the therapeutic effect of endovascular interventional therapy on cerebral venous sinus thrombosis (cvst).137 patients with cvst were included, 92 patients were treated with interventional therapy, and 45 patients were treated with conventional anticoagulant therapy.Through endovascular therapy (evt) combined with therapy, the patients were treated with evt in combination with conventional anticoagulant therapy, and the prognosis of the two groups of patients was evaluated.The results showed that 26 patients were complicated with female‐specific infections in the combined evt group, and 7 patients had female‐specific infections in the simple anticoagulant therapy (lmwh) group.In terms of central nervous system infections, the evt group was significantly lower than the lmwh group, p &lt; 0.001, and the difference was statistically significant.There were 2 cases of evt involving the inferior sagittal sinus and 12 cases of lmwh involving the inferior sagittal sinus, p &lt; 0.001, and the difference had statistical significance.Through the rankin scale (m rs) score, it was classified as complete recovery and good prognosis (dependent variable).The patients receiving evt with good prognosis (96.7%) were more than those receiving simple anticoagulant therapy (84.4%), and 78.3% were completely recovered after evt, and 77.5% were completely recovered after anticoagulant therapy.Therefore, it can be concluded that gender, malignant tumors, thrombosis, and sinuses are all risk factors affecting the prognosis of patients; both endovascular interventional therapy and anticoagulant therapy can significantly improve the prognosis of patients.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Clinical Effect of the Guizhi Shaoyao Zhimu Decoction in the Treatment of Hyperuricemia

Traditional chinese medicine (tcm) is a medical system with a distinctive theoretical framework and extensive experience in identification and treatment acquired by the chinese people in long‐term medical practice and life practice.It is a complete, integrated, and complex knowledge system in epistemology.This study is aimed at exploring the clinical effectiveness of tcm called the guizhi shaoyao zhimu decoction in the treatment of hyperuricemia.A total of 100 patients with hyperuricemia at the medical college of the second clinical college, shandong, china, from january 2019 to january 2022 are selected as the research subjects and divided into group a and group b according to the random table method, with 50 cases in each group.Group a is treated with oral allopurinol tablets, 100 mg, 2 times a day, and group b is treated with the modified guizhi shaoyao zhimu decoction based on group a.For observation, serum uric acid (sua) levels, urinary uric acid (uua) levels, levels of serum inflammatory response factors (il‐6, crp, and tnf‐ α ), vascular endothelial function indexes (serum malondialdehyde (mda) content, nitric oxide (no) content), an acute attack of gout, and the incidence of adverse reactions are measured.Results show that after 2 w and 4 w of treatment, the levels of blood uric acid in each group gradually decreased compared with those before treatment, and group b is lower than group a ( p &lt; 0.05).After treatment, the vascular endothelial function indexes and inflammatory factor levels in each group are significantly improved compared with those before treatment, and the indexes in group b are better than those in group a.There is no significant difference in the incidence of related adverse reactions and acute attack of gout ( p &gt; 0.05).This shows that the tcm guizhi shaoyao zhimu decoction has a significant curative effect in the treatment of patients with hyperuricemia, which is worthy of clinical reference application.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Clinical Effect of Nicorandil Combined with Aspirin in the Treatment of Myocardial Ischemia

To investigate the clinical effect of nicorandil combined with aspirin in the treatment of myocardial ischemia.Methods .A total of 104 patients with myocardial ischemia were admitted to our hospital from june 2019 to august 2020.These patients were selected as the research objects and randomly divided into two groups: the control group and the observation group.The control group was given asilin, and the observation group was given nicorandil tablets based on the control group.Both groups were given continuous treatment for 3 months.The curative effect, cardiac function indexes, dynamic electrocardiogram, and the occurrence of adverse reactions were observed in the two groups.Results .The total effective rate of the observation group was 96.15% (50/52), which was higher than that of the control group (61.54%, 32/52), and the difference was statistically significant ( p &lt; 0.05).After treatment, left ventricular ejection fraction (lvef) and peak early/late diastolic flow velocity (e/a) were increased ( p &lt; 0.05), while peak early diastolic flow velocity to peak mitral annular root movement velocity (e/ea) was decreased ( p &lt; 0.05).After treatment, lvef and e/a in the observation group were higher than those in the control group, while e/ea was lower than that in the control group ( p &lt; 0.05).The frequency, duration of st segment, and a total load of myocardial ischemia in the st segment within 24 h after treatment were decreased compared with those before treatment ( p &lt; 0.05).The frequency and duration of st segment decreased, and the total load of myocardial ischemia in the observation group was lower than those in the control group within 24 h after treatment ( p &lt; 0.05).After treatment, the total occurrence of adverse reactions in the observation group was lower than that in the control group ( p &lt; 0.05).Conclusion .Nicorandil combined with aspirin in the treatment of patients with myocardial ischemia has a significant effect, which can effectively improve the electrocardiogram and cardiac function indicators of patients and reduce the incidence of adverse reactions and is worthy of clinical application.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Clinical Effect of Microneedle Injection Combined with Blood Transfusion in the Treatment of Severe Anemia Complicated with Vitiligo under Regenerative Medical Technology

To explore the clinical efficacy of microneedle injection combined with blood transfusion in the treatment of severe anemia complicated with vitiligo based on regenerative medical technology and provide the theoretical basis for the adoption of microneedle technology, 60 patients with severe anemia complicated with vitiligo were selected as research objects.With 15 patients in each group, they were randomly assigned to the control group (calcipotriol ointment external application), observation group a (external application of moist exposed burn ointment (mebo), observation group b (external application of mebo combined with blood transfusion), and observation group c (microneedle injection of mebo combined with blood transfusion).Blood indexes and plaque recovery of patients in different periods were detected.The total protein (tp) content in group c (62.3 ± 3.3 g/l and 64.3 ± 2.88 g/l) was remarkably higher than that in the control group (51.3 ± 3.17 g/l and 52.4 ± 3.17 g/l) and group a (52.6 ± 2.91 g/l and 51.8 ± 2.98 g/l)) at the 5th and 7th weeks after the treatment ( p &lt; 0.05).The albumin (alb) content in group c (42.9 ± 3.28 g/l and 45.3 ± 3.1 g/l) was signally higher than that in the control group (41.8 ± 3.44 g/l and 41.9 ± 3.23 g/l) and group a (41.3 ± 2.91 g/l and 42.1 ± 3.02 g/l) at the 5th and 7th weeks after the treatment, and the content was markedly higher than that in group b at 5th week ( p &lt; 0.05).The wound healing rates of group c at the 3rd, 5th, and 7th weeks after the treatment (38.44%, 56.6%, and 90.23%) were greatly higher than those of the control group, group a, and group b ( p &lt; 0.05).Besides, the wound healing rate of group b was higher than that of the control group and group a (40.3% and 75.8%) at the 5th and 7th weeks after the treatment ( p &lt; 0.05).To sum up, based on regenerative medical technology, microneedle injection (microneedling is a derma roller process that pricks the skin with minuscule needles.The goal of the treatment is to develop new collagen and skin tissue, resulting in skin that is smoother, firmer, and more toned) combined with blood transfusion had a good therapeutic effect on patients with severe anemia complicated with vitiligo, which could manifestly improve the blood indexes and skin plaques of patients, with a good clinical adoption effect.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Clinical Effect of Digital Subtraction Angiography Combined with Neurointerventional Thrombolysis for Acute Ischemic Cerebrovascular Disease and Its Influence on Vascular Endothelial Function and Oxidative Stress

Ischemic cerebrovascular disease is a commonly seen vascular disorder in clinical practice.Given the difficulty of drug therapy to achieve ideal curative effects, interventional therapy has gradually become the preferred treatment for the disease.This research primarily discusses the short-term efficacy of digital subtraction angiography- (dsa-) guided neurointerventional thrombolysis for acute ischemic cerebrovascular disease (aicvd) and its influence on vascular endothelial function (vef) and oxidative stress (os).Methods.All the clinical data of 162 patients diagnosed with aicvd and treated between june 2019 and december 2021 were collected and analyzed retrospectively.They were assigned to two cohorts according to the difference in interventional methods: a conventional group (cg) given recombinant tissue plasminogen activator (rt-pa) therapy and an observation group (og) intervened by dsa-guided neurointerventional thrombolysis.The two groups were compared with respect to short-term treatment efficacy, the national institutes of health stroke scale (nihss) score, cerebral hemodynamics, and vef and os indexes.Results.The short-term efficacy was better in og (93.98%) than in cg (82.28%).After treatment, the nihss score decreased in both cohorts with obvious differences within the group at different time points, and the posttreatment nihss score was lower in og as compared to cg.Og had higher q m and v m while lower w v , z cv , and r v than cg.Higher endothelial-dependent flow-mediated dilatation (fmd) was observed in og, as well as lower ankle-brachial index (abi) and pulse wave velocity (pwv).And the posttreatment mda was lower while sod, gsh-px, and tac were higher in og compared with those on cg.All the above differences were of statistical significance ( p &lt; 0.05 ).Conclusions.Dsa-guided neurointerventional thrombolysis is highly effective in the treatment of aicvd, which can not only effectively improve patients’ neurological function and cerebral hemodynamics but also mitigate vef injury and help to alleviate patients’ os.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Clinical Correlation Analysis of Complications in Elderly Patients with Sequelae of Stroke with Different Barthel Index in Tianjin Emergency Department

The barthel index (bi) is the most commonly used measure of poststroke disability.The purpose of this article is to explore the different complications and severity of the sequelae of elderly stroke patients with different bi in the emergency department, so as to provide a theoretical basis for strengthening the treatment of elderly patients with stroke sequelae.Methods .A retrospective study was adopted, and 1896 patients were divided into two groups according to the bi: 823 patients in the bedridden group (bi ≤ 40 points) and 1073 patients in the nonbedridden group (bi &gt; 40 points).The type and number of complications and apache ii score were compared between the two groups.Results .Compared with the two groups, pneumonia, renal insufficiency, respiratory failure, and decubitus ulcer in the bedridden group had a higher incidence, but the incidence of upper gastrointestinal bleeding and fractures in the nonbedridden group was significantly higher ( p &lt; 0.05).The apache ii score of the patients in the bedridden group was higher than that of the nonbedridden group, and they were critical ( p &lt; 0.001).And the number of complications was higher than that in the nonbedridden group.Moreover, the bi was negatively correlated with the apache‐ii score and the number of complications, and the apache ii score was positively correlated with the number of complications ( p &lt; 0.001).Conclusion .Different complications and severity of illness occur in elderly patients with sequelae of stroke after different bi in the emergency department.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Cigarette Smoke Regulates the Expression of EYA4 via Alternation of DNA Methylation Status

Cigarette smoke (cs) considerably contributes to causing some diseases such as cancer, and it has a role in the alternation of gene expression through several mechanisms including epigenetics modification, particularly dna methylation.Eya4 is one of the genes, that whose expression has been dysregulated in lung, colon, bladder, and breast cancer, leading to tumor progression.The alternation of dna methylation levels has been implicated in regulating the expression of the eya4 gene.Thus, in this study, we have shown the effect of cs on the dna methylation level of the eya4 promoter region as well as the methylation level on eya4 expression.To determine the level of dna methylation on the promoter region of the eya4 gene, we have employed the bisulfite conversion treatment followed by the sanger sequence for 100 dna samples taken from saudi people (50 smokers and 50 nonsmokers).We found that 26% of dna extracted from smoker samples is methylated, while there was no methylation identified in nonsmoker samples.Also, using the demethylating agents such as aza on lo vo and caco‐2 cancer cell lines causes induction of transcription level of eya4 , implying the possible mechanism of dna methylation in the upregulation of eya4 .These findings suggest the possible mechanism of cs in controlling the expression of eya4 via changing the status of dna methylation.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Chemical Composition and Biological Evaluation of Typha domingensis Pers. to Ameliorate Health Pathologies: In Vitro and In Silico Approaches

Human diseases are becoming more prevalent, necessitating the development of modalities to overcome the challenges of treating various disorders.In the current research, we analyzed the biomedicinal role of typha domingensis which is an important medicinal plant.The species is traditionally used in the treatment of neurological disorders and skin malignancies.The chloroform (cftd) and n ‐butanol fractions of t.Domingensis (bftd) were subjected to chemical profiling through the determination of total polyphenolic contents and gc‐ms analysis.The oral toxicity test was applied to investigate the toxicity of the extracts.Antioxidant capacity was analyzed by four in vitro methods: dpph, abts, frap, and cuprac.The pharmacological potential was evaluated through clinically significant enzyme inhibition assays, thrombolytic, and antimicrobial activities.In silico molecular docking approach was applied to confirm the role of t.Domingensis against the enzymes.The polyphenolic quantification revealed that the bftd was comparatively rich in total phenolic and flavonoid contents (97.14 milligrams gallic acid equivalent (mg gae/g) and 362.5 milligrams quercetin equivalent per gram of dry extract (mg qe/g de), respectively), as compared to the cftd.The gc‐ms analysis of the cftd and bftd resulted in the tentative identification of 67 and 29 compounds, respectively, with the major components of fatty acids and essential oil.The oral toxicity test revealed the safety and biocompatibility of cftd and bftd.Both the fractions showed promising antioxidant activity.Tyrosinase was found as the major enzyme inhibited by bftd (78.67%) and cftd (68.09%), whereas the standard kojic acid showed 85.58% inhibition.The inhibition results of acetylcholinesterase and butyrylcholinesterase by bftd (71.65 and 60.79%, respectively) are higher than cftd.Both the fractions were found active against various strains of bacteria.Furthermore, the molecular docking studies of the compounds showed a good docking score against all the docked enzymes among which deoxycaesaldekarin c was found with the highest binding affinities in comparison to the standard.The current study suggests that t.Domingensis is nontoxic and can be a potential source of phytoconstituents with promising pharmacological potential.

Journal: BioMed Research International (2022)
Publication types: Research Article;
Changes in Expressions of HSP27, HSP70, and Soluble Glycoprotein in Heart Failure Rats Complicated with Pulmonary Edema and Correlations with Cardiopulmonary Functions

The study is aimed at investigating the changes in expressions of heat shock protein 27 (hsp27), hsp70, and soluble glycoprotein (sgp) in heart failure (hf) rats complicated with pulmonary edema and exploring their potential correlations with cardiopulmonary functions.The rat model of hf was established, and the rats were divided into hf model group (model group, n = 15) and normal group ( n = 15).After successful modeling, mri and ecg were applied to detect the cardiac function indexes of the rats.The myocardial function indexes were determined, the injury of myocardial tissues was observed via hematoxylin and eosin (he) staining, and the content of myeloperoxidase (mpo), matrix metalloproteinase‐9 (mmp‐9), and tumor necrosis factor‐alpha (tnf‐ α ) in the blood was measured.The partial pressure of oxygen (pa o 2 ) and oxygenation index (oi) were observed, and the airway resistance and lung compliance were examined.Moreover, quantitative polymerase chain reaction (q pcr) and western blotting assay were performed to detect the gene and protein expression levels of hsp27, hsp70, and sgp130.The levels of serum creatine kinase (ck), creatine (cr), and blood urea nitrogen (bun) were increased markedly in model group ( p &lt; 0.05).Model group had notably decreased fractional shortening (fs) and ejection fraction (ef) compared with normal group ( p &lt; 0.05), while the opposite results of left ventricular end‐diastolic diameter (lvedd) and left ventricular end‐systolic diameter (lvesd) were detected.In model group, the content of serum mpo, mmp‐9, and tnf‐ α was raised remarkably ( p &lt; 0.05), oi and pa o 2 were reduced notably ( p &lt; 0.05), the airway resistance was increased ( p &lt; 0.05), and the lung compliance was decreased ( p &lt; 0.05).Obviously elevated gene and protein expression levels of hsp27, hsp70, and sgp130 were detected in model group ( p &lt; 0.05).The expressions of hsp27, hsp70, and sgp130 are increased in hf rats complicated with pulmonary edema, seriously affecting the cardiopulmonary functions of the rats.

Journal: BioMed Research International (2021)
Publication types: Research Article;
Central Composite Designed Fast Dissolving Tablets for Improved Solubility of the Loaded Drug Ondansetron Hydrochloride

Ondansetron tablets that are directly compressed using crospovidone and croscarmellose as a synthetic super disintegrant are the subject of this investigation.A central composite, response surface, randomly quadratic, nonblock (version 13.0.9.0) 3 2 factorial design is used to optimize the formulation (two‐factor three‐level).To make things even more complicated, nine different formulation batches (designated as f1–f9) were created.There were three levels of crospovidone and croscarmellose (+1, 0, ‐1).In addition to that, pre‐ and postcompressional parameters were evaluated, and all evaluated parameters were found to be within acceptable range.Among all postcompressional parameter dispersion and disintegration time, in vitro drug release experiments (to quantify the amount of medication released from the tablet) and their percentage prediction error were shown to have a significant influence on three dependent variables.Various pre‐ and postcompression characteristics of each active component were tested in vitro .Bulk density, tap density, angle of repose, carr’s index, and the hausner ratio were all included in this analysis, as were many others.This tablet’s hardness and friability were also assessed along with its dimension and weight variations.Additional stability studies may be conducted using the best batch of the product.For this study, we utilised the design‐expert software to select the formulation f6, which had dispersion times of 17.67 ± 0.03 seconds, disintegration times of 120.12 ± 0.55 seconds, and percentage drug release measurements of 99.25 ± 0.36 within 30 minutes.Predicted values and experimental data had a strong correlation.Fast dissolving pills of ondansetron hydrochloride may be created by compressing the tablets directly.

Journal: BioMed Research International (2022)
Publication types: Research Article;