syedzayyan/paper_mill_benchmark huggingface dataset:
Physiological Responses and Metabonomics Analysis of Male and FemaleSargassum thunbergiiMacroalgae Exposed to Ultraviolet-B Stress.

Ultraviolet-b (uv-b) radiation is a major environmental stress that suppresses or activates defense responses in organisms.Uv-b radiation affecting growth and development in intertidal species have been researched for a long time, but a series of unknown knowledge remain in the male and female macroalgae comparison.To compare the different responses of male and female sargassum thunbergiimacroalgae under uv-b radiation, psii photochemical efficiency determination, metabolomic analysis, and main carbon-based metabolites (including soluble sugar, total amino acid, and lipid) content measuring have been performed in our experiments.Results showed that males have significantly superiority performance in the chlorophyll fluorescence parameters of fv/fm, y(ii), and y(no) either low or high uv-b radiation treatments.Metabolomics analysis revealed that carbon and nitrogen metabolism pathways in male and female s.Thunbergiiwere significant components responding to enhanced uv-b radiation.Based on measuring, female s.Thunbergiilipid content expressed higher than males without any stimulation.Additionally, under low uv-b radiation stimulation, females total amino acid content shown significantly higher than control group and their lipid content also significantly higher than males.Under high uv-b radiation, males soluble sugar, total amino acid, and lipid content significantly varied from females, which meant that enhancing uv-b stress might altered mainly carbon-based metabolites flowing directions.The present study elucidated the potential role of enhanced uv-b radiation in regulating macroalgae physiological responses, metabolites changing, and reflecting differences between male and female s.Thunbergii, contributing to understanding of brown-macroalgae diecious adopting mechanisms in defending intertidal uv-b stresses.

Journal: Frontiers in plant science (2022)
Publication types: Journal Article
The use of smart technologies in enabling construction components reuse: A viable method or a problem creating solution?

The exploitation of radio frequency identification (rfid) for tracking and archiving the properties of structural construction components could be a potentially innovative disruption for the construction sector.This is because rfid can stimulate the reuse of construction components and reduce their wastage, hence addressing sustainability issues in the construction sector.To test the plausibility of that idea, this study explores the potential pre-conditions for rfid to facilitate construction components reuse, and develops a guidance for promoting their redistribution back to the supply chain.It also looks at how integrating rfid with building information modelling (bim) can possibly be a valuable extension of its capabilities, providing the opportunity for tracked components to be incorporated into new structures in an informed, sound way.A preliminary assessment of the strengths, weaknesses, opportunities and threats of the rfid technology is presented in order to depict its current and future potential in promoting construction components' sustainable lifecycle management, while emphasis has been laid on capturing their technical, environmental, economic and social value.Findings suggest that the collection of the right amount of information at the design-construction-deconstruction-reuse-disposal stage is crucial for rfid to become a successful innovation in the construction sector.Although a number of limitations related to the technical operability and recycling of rfid tags seem to currently hinder its uptake for structural components' lifecycle management, future technological innovations could provide solutions that would enable it to become a mainstream practice.Taken together these proposals advocate that the use of rfid and its integration with bim can create the right environment for the development of new business models focused on sustainable resource management.These models may then unlock multiple values that are otherwise dissipated in the system.If the rapid technological development of rfid capability can be allied to policy interventions that control and manage its uptake along the supply chain, the sustainable lifecycle management of construction components could be radically enhanced.

Journal: Journal of environmental management (2018)
Publication types: Journal Article
Crystalline Anionic Germanate Covalent Organic Framework for High CO2Selectivity and Fast Li Ion Conduction.

The metalloid-centered covalent organic framework has attracted great interest from both its structure and application.Heavier elements have seldomly been incorporated in the covalent organic frameworks, even if they exhibit special structural features and properties.Herein, we reported the first crystalline germanate covalent organic framework with hexacoordinated germanate linked by an anthracene linker.The existence of counterion lithium ions in the framework provides a high co2uptake of 88.5 cm3g-1at 273 k and a high co2/n2selectivity of 101.A significantly improved lithium ion conductivity of 0.25 m s cm-1at room temperature was observed due to the soft germanium center.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (2019)
Publication types: Journal Article
Posterior Rectus Sheath Defect with Interparietal Hernia Causing a Small Bowel Obstruction.

Posterior rectus sheath hernias are exceptionally rare, with around twelve reported cases to date.This case report examines a 38-year-old female who demonstrated symptoms of intermittent small bowel obstruction five days following an abdominal hysterectomy.The patient was diagnosed via ct to have a small bowel obstruction within the rectus abdominis.Exploratory laparotomy determined the etiology to be an interparietal hernia through a posterior rectus wall defect, which was repaired with primary closure.Postoperatively, the patient was again unable to tolerate food.Repeat ct showed concern for repeat sbo, though symptoms subsided without intervention.The patient had no complaints during her follow up at one month.This report was aimed at building upon the few reported cases as well as enumerating potential risk factors that may allow for the consideration of this diagnosis in the future.

Journal: Case reports in surgery (2022)
Publication types: Case Reports;Journal Article
A Cross-Sectional Study of the Marital Attitudes of Pregnant Women at Risk for Cystic Fibrosis and Psychological Impact of Prenatal Screening.

Cystic fibrosis (cf) is one of the most frequent genetic disorders in those with northern european ancestry.Prenatal testing for cystic fibrosis may be used to plan and prepare for the birth of a child with the disease or to determine whether to terminate the pregnancy.The accessibility of prenatal detection for women with a high genetic risk of delivering a child with cystic fibrosis is determined by cf carriers and those affected by the disease.Moreover, prenatal testing for cf is mainly dependent on invasive diagnostic tests that can influence the mental health of the pregnant woman, and it is assumed that the birth of a cf child will have a serious influence on the couple's subsequent family planning and marital behavior.The purpose of this research was to examine the marital attitudes of women at risk for cystic fibrosis and the psychological effect of screening for cf among pregnant women.The study followed a cross-sectional design with five questionnaires comprising prenatal attachment interview (pai), maternal antenatal attachment scale (maas), pregnancy-related anxiety questionnaire (praq-r2), the prenatal psychosocial profile (ppp), and the marital intimacy questionnaire (miq).A total of 84 pregnant women were included in the "carriers" group for cftr and 91 in the "non-carrier" group.Cftr-carrier mothers were likely to be more affectionate to the fetus, with better maternal-fetal quality and intensity of attachment.The same group of pregnant women was less scared of giving birth or worried about bearing a physically or mentally handicapped child compared to women who were expecting the prenatal diagnosis test for being at risk of delivering a newborn with malformations.Cftr-carrier pregnant women did not score significantly different results in the prenatal psychosocial profile regarding stress levels, social support, and self-esteem.It was also found that intimacy and consensus problems inside the marriage were significantly more often experienced by cftr carriers.Based on the current findings, it is likely that cftr-carrier mothers have a better perception of the possible pregnancy outcomes by knowing their abnormal gene carrier status.Therefore, the psychological impact of invasive diagnostic tests is lower in this category compared with those who are unaware of the possible pregnancy outcomes.However, we promote a future analysis for pregnant women with moderate risk of giving birth to a child with single-gene mutations such as cystic fibrosis or other congenital malformations that undergo noninvasive prenatal diagnosis tests, as they become more accurate and might cause lower pre-diagnosis stress levels.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article
The abuse liability of ketamine: A scoping review of preclinical and clinical studies.

While ketamine has been used clinically over the past decades, it has only been recently shown to be a promising therapy for treatment-resistant depression (trd).However, ketamine and related dissociative agents may also be misused recreationally, creating significant concerns for abuse liability when prescribed for depression.Although the abuse potential of ketamine is widely recognized, there is limited evidence on the differential abuse liability of ketamine enantiomers, (s)-ketamine and (r)-ketamine.The current scoping review aims to summarize the extant literature on the abuse liability of (r,s)-ketamine and the enantiomers.A systematic search was conducted on the embase, medline, and apa psyc info databases from 1947 to july 29, 2021.Clinical and preclinical studies that assessed the abuse potential of (r,s)-ketamine, (s)-ketamine, and (r)-ketamine were screened and assessed for eligibility by two independent reviewers.A total of 65 eligible studies were identified; 55 were preclinical studies and 10 were clinical studies.Only 4 preclinical studies evaluated the abuse liability of ketamine enantiomers.Available preclinical evidence suggests that (r,s)-ketamine and (s)-ketamine have greater risk for abuse compared to (r)-ketamine.(r)-ketamine, at the antidepressant-relevant doses in rodents, appears to be safe with minimal liability for abuse.Although the abuse potential of (r,s)-ketamine is well-established in animals, limited clinical studies indicate that single or repeated ketamine administrations in professionally controlled settings did not result in misuse, dependence, diversion and/or gateway activity in patients with trd.However, most clinical studies were retrospective and did not systematically evaluate the abuse liability of ketamine via validated psychological scales/questionnaires.Future randomized controlled trials are warranted to ascertain the abuse liability of racemic, (s)- and (r)-ketamine in trd population, especially among patients with comorbid substance use disorders.

Journal: Journal of psychiatric research (2022)
Publication types: Journal Article;Review
Psychopharmacology of sleep disorders.

The concept of psychopharmacology has particular applicability to the study of sleep because the states of sleep and wake are so intensely and complexly neurophysiologic in nature.Growing understanding of the structure and function of the neural pathways involved is increasing the capacity to devise targeted pharmacologic interventions to address maladaptions and malfunctions that result in various sleep-related disorders and better ways to promote or replicate sleep in situations where it is needed but does not occur naturally.In this chapter we review the neurobiology of sleep and wake states, and how this relates to understanding of common sleep problems and their pharmacologic treatment.

Journal: Handbook of clinical neurology (2019)
Publication types: Journal Article;Review
MR findings of uterine PEComa in patients with tuberous sclerosis: report of two cases.

Tuberous sclerosis complex (tsc), a rare autosomal dominant neurocutaneous disorder, is characterized by the presence of benign congenital tumors in multiple organs.Neoplasms with perivascular epithelioid cell differentiation (pecomas), including angiomyolipoma (aml) and lymphangioleiomyomatosis (lam), can occur in association with tsc.This report describes two cases of uterine pecomas presenting characteristic mr imaging features reflecting pathological findings.From mr images, both cases showed single or multiple large, irregularly shaped or lobulated hemorrhagic lesions within the myometrium.They differed from typical adenomyotic cysts in their large size and irregular margins.Histopathologic analysis revealed that the hemorrhage was caused by adenomyosis and tumor cells that proliferated in surrounding stroma of the hemorrhagic lesions, compatible with pecomas.Microscopic observation revealed an infiltrative growth pattern of pecomas, with small nodules formed.The tumor lesions, however, were difficult to detect on mr images.The myometrium showed normal appearance on both t1-weighted and t2-weighted images in both cases.We speculate that pecomas may infiltrate extensively into the myometrium even when the myometrium shows almost normal radiologic appearance.

Journal: Abdominal radiology (New York) (2019)
Publication types: Case Reports;Journal Article
Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein Using mRNA Display.

The covid-19 pandemic, caused by sars-co v-2, has led to substantial morbidity, mortality, and disruption globally.Cellular entry of sars-co v-2 is mediated by the viral spike protein, and affinity ligands to this surface protein have the potential for applications as antivirals and diagnostic reagents.Here, we describe the affinity selection of cyclic peptide ligands to the sars-co v-2 spike protein receptor binding domain (rbd) from three distinct libraries (in excess of a trillion molecules each) by m rna display.We identified six high affinity molecules with dissociation constants (kd) in the nanomolar range (15-550 n m) to the rbd.The highest affinity ligand could be used as an affinity reagent to detect the spike protein in solution by elisa, and the cocrystal structure of this molecule bound to the rbd demonstrated that it binds to a cryptic binding site, displacing a β-strand near the c-terminus.Our findings provide key mechanistic insight into the binding of peptide ligands to the sars-co v-2 spike rbd, and the ligands discovered in this work may find future use as reagents for diagnostic applications.

Journal: ACS central science (2021)
Publication types: Journal Article
Antioxidant and Antiglycation Effects ofCistus × incanusWater Infusion, Its Phenolic Components, and Respective Metabolites.

Reactive oxygen and carbonyl species promote oxidative and carbonyl stress, and the development of diabetes, metabolic syndrome, cardiovascular diseases, and others.The traditional herb cistus × incanusis known for its antioxidant properties; therefore, the current study aimed to assess how the chemical composition of a c.Incanuswater infusion corresponds with its antioxidative and antiglycative effects in vitro.The composition of infusions prepared from commercial products was analyzed with uhplc-esi-q tof-ms.Total phenolics, flavonoids, and non-flavonoid polyphenols were determined.Antioxidant activity of infusions and selected polyphenols was investigated using dpph, abts, and frap.Fluorometric measurements and methylglyoxal capture were performed to investigate the antiglycation activity.Pca and pls-da models were applied to explore the correlation between chemical and antioxidant results.The principal flavonoids in c.Incanuswere flavonols.In vitro tests revealed that a stronger antioxidant effect was demonstrated by plant material from turkey rich in flavonoids, followed by albania and greece.Flavonols and ellagic acid displayed stronger antiradical and reducing power than ea-derived urolithins.Hyperoside was the most potent inhibitor of glycation.The results indicate that flavonoids are primarily responsible for rock rose antioxidant and antiglycation properties.Pls-da modeling can be used to identify the origin of plant material with sensitivity and specificity exceeding 86%.

Journal: Molecules (Basel, Switzerland) (2022)
Publication types: Journal Article
Genetic and phenotypic parameters for body weights, harvest length, and growth curve parameters in American mink.

Understanding the genetics underlying growth curve is important for selection of animals with better growth potential, but little is known about the genetics of growth curve parameters in mink.This study estimated the genetic parameters for body weights (bws), harvest length (hl), and growth parameters derived from the richards model.For this purpose, individual bw of 1,088 mink measured seven times in 3-wk intervals (weeks 13 to 31 of life) were used for growth curve modeling using the richards model.The bw traits included bw at week 13 (bw13), 16 (bw16), 19 (bw19), 22 (bw22), 25 (bw25), 28 (bw28), and 31 (bw31).Univariate analyses indicated that sex and birth-year had significant effects (p 0.05) genetic correlations (±se) with k (-0.21 ± 0.23) and m (-0.10 ± 0.22), suggesting that changing shape parameters (k and m) will not influence asymptotic weight (α).Strong significant (p 0.05) genetic correlations with hl, indicating the change of the curve shape could not influence hl.Overall, the results suggest that growth curve parameters are heritable and can respond to genetic or genomic selection for optimizing the performance in mink.

Journal: Journal of animal science (2021)
Publication types: Journal Article
An Overview of Antimicrobial Resistance Profiles of Publicly AvailableSalmonellaGenomes with Sufficient Quality and Metadata.

Salmonella enterica(s.enterica) is a commensal organism or pathogen causing diseases in animals and humans, as well as widespread in the environment.Antimicrobial resistance (amr) has increasingly affected both animal and human health and continues to raise public health concerns.A decade ago, it was estimated that the increased use of whole genome sequencing (wgs) combined with sharing of public data would drastically change and improve the surveillance and understanding of salmonellaepidemiology and amr.This study aimed to evaluate the current usefulness of public wgs data for salmonellasurveillance and to investigate the associations between serovars, antibiotic resistance genes (args), and metadata.Out of 191,306salmonellagenomes deposited in european nucleotide archive and ncbi databases, 47,452 wgs with sufficient minimum metadata (country, year, and source) of s.Entericawere retrieved from 116 countries and isolated between 1905 and 2020.Forin silicoanalysis of the wgs data, kmer finder, sistr, and res finder were used for species, serovars, and amr identification, respectively.The results showed that the five common isolation sources of s.Entericaare human (29.10%), avian (22.50%), environment (11.89%), water (9.33%), and swine (6.62%).The most common arg profiles for each class of antimicrobials are β-lactam (bla tem-1b; 6.78%), fluoroquinolone [(par c[t57s],qnr b19); 0.87%], folate pathway antagonist (sul2; 8.35%), macrolide [mph(a); 0.39%], phenicol (flo r; 5.94%), polymyxin b (mcr-1.1; 0.09%), and tetracycline [tet(a); 12.95%].Our study reports the first overview of arg profiles in publicly available salmonellagenomes from online databases.All data sets from this study can be searched at microreact.

Journal: Foodborne pathogens and disease (2023)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy.

Whether differences in circulating long chain acylcarnitines (lcac) are seen in heart failure (hf) patients with and without diabetes mellitus (dm), and whether these biomarkers report on exercise capacity and clinical outcomes, remains unknown.The objective of the current study was to use metabolomic profiling to identify biomarkers that report on exercise capacity, clinical outcomes, and differential response to exercise in hf patients with and without dm.Methods targeted mass spectrometry was used to quantify metabolites in plasma from participants in the heart failure: a controlled trial investigating outcomes of exercise training (hf-action) trial.Principal components analysis was used to identify 12 uncorrelated factors.The association between metabolite factors, diabetes status, exercise capacity, and time to the primary clinical outcome of all-cause mortality or all-cause hospitalization was assessed.Results a total of 664 participants were included: 359 (54%) with dm.Lcac factor levels were associated with baseline exercise capacity as measured by peak oxygen consumption (beta 0.86, p = 2 × 10-7, and were differentially associated in participants with and without dm (beta 1.58, p = 8 × 10-8vs.0.67, p = 9 × 10-4, respectively; p value for interaction = 0.012).Lcac levels changed to a lesser extent in participants with dm after exercise (mean ∆ 0.09, p = 0.24) than in those without dm (mean ∆ 0.16, p = 0.08).In univariate and multivariate modeling, lcac factor levels were associated with time to the primary outcome (multivariate hr 0.80, p = 2.74 × 10-8), and were more strongly linked to outcomes in diabetic participants (hr 0.64, p = 3.21 × 10-9v.Hr 0.90, p = 0.104, p value for interaction = 0.001).When analysis was performed at the level of individual metabolites, c16, c16:1, c18, and c18:1 had the greatest associations with both exercise capacity and outcomes, with higher levels associated with worse outcomes.Similar associations with time to the primary clinical outcome were not found in a control group of patients without hf from the catheterization genetics (cathgen) study.Conclusions lcac biomarkers are associated with exercise status and clinical outcomes differentially in hf patients with and without dm.Impaired fatty acid substrate utilization and mitochondrial dysfunction both at the level of the skeletal muscle and the myocardium may explain the decreased exercise capacity, attenuated response to exercise training, and poor clinical outcomes seen in patients with hf and dm.Trial registration clinicaltrials.gov identifier: nct00047437.

Journal: Cardiovascular diabetology (2021)
Publication types: Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't