syedzayyan/paper_mill_benchmark huggingface dataset:
A holistic assessment of spatiotemporal variation, driving factors, and risks influencing river water quality in the northeastern Qinghai-Tibet Plateau.

The qinghai-tibet plateau (qtp) is the source for many of the most important rivers in asia.It is also an essential ecological barrier in china and has the characteristic of regional water conservation.Given this importance, we analyzed the spatiotemporal distribution patterns and trends of 10 water quality parameters.These measurements were taken monthly from 67 monitoring stations in the northeastern qtp from 2015 to 2019.To evaluate water quality trends, major factors influencing water quality, and water quality risks, we used a series of analytical approaches including mann-kendall test, boruta algorithm, and interval fuzzy number-based set-pair analysis (ifn-spa).The results revealed that almost all water monitoring stations in the northeastern qtp were alkaline.From 2015 to 2019, the water temperature and dissolved oxygen of most monitoring stations were significantly reduced.Chemical oxygen demand, permanganate index, five-day biochemical oxygen demand, total phosphorus, and fluoride all showed a downward trend across this same time frame.The annual average total nitrogen (tn) concentration fluctuation did not significantly decrease across the measured time frame.Water quality index (wqi-det) indicated bad or poor water quality in the study area; however, water quality index without tn (wqi-det') reversed the water quality value.The difference between the two indexes suggested that tn was a significant parameter affecting river water quality in the northeastern qtp.Both spearman correlation and boruta algorithm show that elevation, urban land, cropland, temperature, and precipitation influence the overall water quality status in the northeastern qtp.The results showed that between 2015 and 2019, most rivers monitored had a relatively low risk of degradation in water quality.This study provides a new perspective on river water quality management, pollutant control, and risk assessment in an area like the qtp that has sensitive and fragile ecology.

Journal: The Science of the total environment (2022)
Publication types: Journal Article
Plasma Oscillation Behavior and Electromagnetic Interference Shielding of Carbon Nanofibers/Conductive Polymer Metacomposites at Radarwave Frequency.

Metacomposites have attracted widespread attention due to their unique negative electromagnetic properties and stupendous applications.Although there are systems that realize metamaterial properties in low radio frequency bands, the research on the construction of polymer matrix metacomposites with negative performance in the pivotal ghz band is still undiscovered.Herein, carbon nanofiber/conductive polymer metacomposites with 3d overlapping network structures are innovatively constructed to achieve negative permittivity characteristics in the radarwave frequency range, and convenient methods for further adjusting the electromagnetic parameters is also proposed.The results show that the negative permittivity of cnfs/pani metacomposites can be conveniently altered via adjusting pani content.Furthermore, electromagnetic shielding has also been fully discussed as one of the most valuable applications of the metacomposites.The setof cnfs/pani-70 has an average value of 70 d b at 4-18 ghz and can reach a maximum of 80 d b at 4 ghz, which far exceeds the current commercial electromagnetic shielding standards.This work greatly broadens the promising application of metacomposites for perfect electromagnetic shielding, novel capacitance, and frequency selective surfaces.

Journal: Macromolecular rapid communications (2022)
Publication types: Journal Article
DNA methylation-based biomarkers and the epigenetic clock theory of ageing.

Identifying and validating molecular targets of interventions that extend the human health span and lifespan has been difficult, as most clinical biomarkers are not sufficiently representative of the fundamental mechanisms of ageing to serve as their indicators.In a recent breakthrough, biomarkers of ageing based on dna methylation data have enabled accurate age estimates for any tissue across the entire life course.These 'epigenetic clocks' link developmental and maintenance processes to biological ageing, giving rise to a unified theory of life course.Epigenetic biomarkers may help to address long-standing questions in many fields, including the central question: why do we age?

Journal: Nature reviews. Genetics (2018)
Publication types: Journal Article;Review
Understanding and utilizing crop genome diversity via high-resolution genotyping.

High-resolution genome analysis technologies provide an unprecedented level of insight into structural diversity across crop genomes.Low-cost discovery of sequence variation has become accessible for all crops since the development of next-generation dna sequencing technologies, using diverse methods ranging from genome-scale resequencing or skim sequencing, reduced-representation genotyping-by-sequencing, transcriptome sequencing or sequence capture approaches.High-density, high-throughput genotyping arrays generated using the resulting sequence data are today available for the assessment of genomewide single nucleotide polymorphisms in all major crop species.Besides their application in genetic mapping or genomewide association studies for dissection of complex agronomic traits, high-density genotyping arrays are highly suitable for genomic selection strategies.They also enable description of crop diversity at an unprecedented chromosome-scale resolution.Application of population genetics parameters to genomewide diversity data sets enables dissection of linkage disequilibrium to characterize loci underlying selective sweeps.High-throughput genotyping platforms simultaneously open the way for targeted diversity enrichment, allowing rejuvenation of low-diversity chromosome regions in strongly selected breeding pools to potentially reverse the influence of linkage drag.Numerous recent examples are presented which demonstrate the power of next-generation genomics for high-resolution analysis of crop diversity on a subgenomic and chromosomal scale.Such studies give deep insight into the history of crop evolution and selection, while simultaneously identifying novel diversity to improve yield and heterosis.

Journal: Plant biotechnology journal (2016)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
Reductive Carbon-Carbon Coupling on Metal Sites Regulates Photocatalytic CO2Reduction in Water Using ZnSe Quantum Dots.

Colloidal quantum dots (qds) consisting of precious-metal-free elements show attractive potentials towards solar-driven co2reduction.However, the inhibition of hydrogen (h2) production in aqueous solution remains a challenge.Here, we describe the first example of a carbon-carbon (c-c) coupling reaction to block the competing h2evolution in photocatalytic co2reduction in water.In a specific system taking zn se qds as photocatalysts, the introduction of furfural can significantly suppress h2evolution leading to co evolution with a rate of ≈5.3 mmol g-1h-1and a turnover number (ton) of >7500 under 24 h visible light.Meanwhile, furfural is upgraded to the self-coupling product with a yield of 99.8 % based on the consumption of furfural.Mechanistic insights show that the reductive furfural coupling reaction occurs on surface zn-sites to consume electrons and protons originally used for h2production, while the co formation pathway at surface anion vacancies from co2remains.

Journal: Angewandte Chemie (International ed. in English) (2022)
Publication types: Journal Article
Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex.

The cytoskeleton of eukaryotic cells is primarily composed of networks of filamentous proteins, f-actin, microtubules, and intermediate filaments.Interactions among the cytoskeletal components are important in determining cell structure and in regulating cell functions.For example, f-actin and microtubules work together to control cell shape and polarity, while the subcellular organization and transport of vimentin intermediate filament (vif) networks depend on their interactions with microtubules.However, it is generally thought that f-actin and vifs form two coexisting but separate networks that are independent due to observed differences in their spatial distribution and functions.In this paper, we present a closer investigation of both the structural and functional interplay between the f-actin and vif cytoskeletal networks.We characterize the structure of vifs and f-actin networks within the cell cortex using structured illumination microscopy and cryo-electron tomography.We find that vifs and f-actin form an interpenetrating network (ipn) with interactions at multiple length scales, and vifs are integral components of f-actin stress fibers.From measurements of recovery of cell contractility after transient stretching, we find that the ipn structure results in enhanced contractile forces and contributes to cell resilience.Studies of reconstituted networks and dynamic measurements in cells suggest direct and specific associations between vifs and f-actin.From these results, we conclude that vifs and f-actin work synergistically, both in their structure and in their function.These results profoundly alter our understanding of the contributions of the components of the cytoskeleton, particularly the interactions between intermediate filaments and f-actin.

Journal: Proceedings of the National Academy of Sciences of the United States of America (2022)
Publication types: Journal Article
Impact of multicentre diagnostic workup in patients with pancreatic cancer on repeated diagnostic investigations, time-to-diagnosis and time-to-treatment: A nationwide analysis.

Due to the centralization of pancreatic surgery, patients with suspected pancreatic cancer may undergo diagnostic workup in both a non-pancreatic centre and a pancreatic centre, i.e.Multicentre workup.This retrospective study assessed whether multicentre diagnostic workup is associated with repeated diagnostics, delayed time-to-diagnosis, delayed time-to-treatment, survival and whether variation existed among pancreatic cancer networks.Methods this nationwide study included all patients diagnosed with non-metastatic pancreatic ductal adenocarcinoma (pdac) in 2015, registered by the netherlands cancer registry.A delayed time-to-diagnosis was defined as ≥3 weeks from initial hospital visit to final diagnosis.A delayed time-to-treatment was defined as ≥6 weeks from the first hospital visit to start of first tumour treatment.Multilevel logistic regression analyses and survival analyses were performed.Results in total, 931 patients with non-metastatic pdac were included.Overall, 175 patients (19%) underwent a multicentre diagnostic workup, which was significantly associated with repeated diagnostic investigations (or = 6.31, 95% ci 4.13-9.64, p < 0.0001), a delayed time-to-diagnosis (or = 2.66 95% ci 1.74-4.06, p < 0.001), and a delayed time-to-treatment (or = 1.93 95% ci 1.12-3.31, p = 0.02), but not with decreased survival (hr = 1.09 95% ci 0.83-1.44; p = 0.532).Variation in outcomes per network was observed, especially for time-to-treatment, though the icc was not statistically significant (p = 0.065).Conclusion multicentre diagnostic workup for patients with pdac is associated with repeated diagnostic investigations, a delayed time-to-diagnosis and delayed time-to-treatment compared to patients with monocentre workup.To reduce costs and improve treatment times, efforts should be made to improve network coordination, for example via network care pathways.

Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (2022)
Publication types: Multicenter Study;Journal Article
Multilabel Acoustic Event Classification Using Real-World Urban Data and Physical Redundancy of Sensors.

Many people living in urban environments nowadays are overexposed to noise, which results in adverse effects on their health.Thus, urban sound monitoring has emerged as a powerful tool that might enable public administrations to automatically identify and quantify noise pollution.Therefore, identifying multiple and simultaneous acoustic sources in these environments in a reliable and cost-effective way has emerged as a hot research topic.The purpose of this paper is to propose a two-stage classifier able to identify, in real time, a set of up to 21 urban acoustic events that may occur simultaneously (i.e., multilabel), taking advantage of physical redundancy in acoustic sensors from a wireless acoustic sensors network.The first stage of the proposed system consists of a multilabel deep neural network that makes a classification for each 4-s window.The second stage intelligently aggregates the classification results from the first stage of four neighboring nodes to determine the final classification result.Conducted experiments with real-world data and up to three different computing devices show that the system is able to provide classification results in less than 1 s and that it has good performance when classifying the most common events from the dataset.The results of this research may help civic organisations to obtain actionable noise monitoring information from automatic systems.

Journal: Sensors (Basel, Switzerland) (2021)
Publication types: Journal Article
The Impact of Implementing an Exergame Program on the Level of Reaction Time Optimization in Handball, Volleyball, and Basketball Players.

The main aim of the present study was to implement an exergame program that uses fitlight technology to identify the impact on motor, recognition, and cognitive reaction times in junior athletes practicing team sports: basketball, handball, and volleyball.The second aim was to identifying differences in progress of the three types of reaction time between female and male players through computerized tests.The study included 360 subjects for basketball, 130 athletes of which were 68 male subjects and 62 female subjects; for handball, 124 athletes of which 64 were male subjects and 60 female athletes; for volleyball, 106 athletes of which 48 male were subjects and 48 female athletes.Characteristics of the experimental players: average age ± sd 13.60 ± 1.07; average sports experience ± sd 6.24 ± 0.92.The research included an initial and a final test between which a program of exergames was implemented over a period of 3 months focused on optimizing human reaction times.The evaluation of the reaction times was carried out through three computer games, the results being processed in spss 22.The relevant results of the research: for the simple motor reaction time (msrt), the greatest progress between tests was the volleyball group, and for women, it was the basketball group; for the recognition reaction time (rrt), the male handball group and the female basketball group recorded the greatest progress; for the cognitive reactive time (crt), the greatest progress was achieved by the male and female volleyball players.In all tests, the progress of the female basketball, handball, and volleyball players showed superior progress to similar male players.The results of the research highlighted the effectiveness of the experimental exergame program by using fitlight technology in optimizing human reaction times in junior team-game athletes.Using computer games to evaluate reaction times allowed us to differentiate the evaluation on the types of human reactions under both standardized conditions but also under conditions of efficiency and attractiveness.

Journal: International journal of environmental research and public health (2022)
Publication types: Journal Article
Influence of Excessively High Temperatures on the Fruit Growth and Physicochemical Properties of Shiranuhi Mandarin in Plastic-Film Greenhouse Cultivation.

Excessively high temperatures frequently occur between spring and late fall because of global warming.These problems have a negative effect on fruit production capacity and actual production.However, there is a lack of information on the effects of excessively high temperatures (exceeding the optimum range) on the growth of citrus fruits.Thus, the objective of this present study was to determine the effects of excessively high temperatures on shiranuhi mandarin fruit growth, physiological characteristics, amino acid contents, and antioxidant activity.In this study, five different high-temperature treatments were applied: normal atmospheric temperature (con), con + 4 °c during the day (d4), con + 8 °c during the day (d8), con + 4 °c during the night (n4), and con + 4 °c during the day and night (dn4).The total soluble sugar contents were lowest in d8, and the acid content under dn4 was significantly lower than that under con.Rising temperature during the day or night affected the colouration of the rind, and the free sugar composition ratio under d8 was lower than those under the other treatments.The total amino acid content tended to increase with increasing temperature during the day.The total flavonoid and total phenolic contents in the peel were significantly higher under con and n4 than the other treatments and in the pulp under con.

Journal: Plants (Basel, Switzerland) (2021)
Publication types: Journal Article
Case study: Malakoplakia of the bladder.

S malakoplakia is a rare chronic inflammatory disease thought to be the result of defective bacterial phagocytosis and lysosome function, and there is difficulty in accurate diagnosis as a result of non-specific symptoms that mimic other diseases and cancers.This study presents a case of bladder malakoplakia associated with renal failure presenting as a tumor.Methods a 55-year-old woman with history of kidney disease who presented with general malaise and worsening renal failure was found to have a bladder mass and underwent transurethral resection of bladder tumor (turbt), and subsequent histological examination.Results the bladder mass consisted of basophilic structures known as michaelis-gutmann bodies within clusters of macrophages on histological examination, and stained positive for cd68.Von kossa stain highlights michaelis-gutmann bodies, consistent with the diagnosis of malakoplakia.Conclusions conservative treatment via antibiotics has been effective.Proper diagnosis of bladder malakoplakia is important, as the conditions it mimics often require surgery and resection.Additionally, it is important to recognize the implications bladder malakoplakia has on renal functioning, particularly regarding urinary obstruction.

Journal: Pathology, research and practice (2022)
Publication types: Case Reports;Journal Article
Racial-Ethnic Differences in Service Use Patterns Among Young, Commercially Insured Individuals With Recent-Onset Psychosis.

The aim of this study was to investigate racial-ethnic differences in use of mental health services and antipsychotic medication in the year following the recent onset of a psychotic disorder and to examine the role of household income as a proxy for socioeconomic status.Methods deidentified administrative claims data from the optum labs data warehouse were used to identify 8,021 commercially insured individuals ages 14 through 30 with a recent-onset psychotic disorder (january 1, 2011, through december 31, 2015).The authors compared mental health service use among african-american (11.5%), hispanic (11.0%), and non-hispanic white (77.4%) individuals during the year following an index diagnosis and adjusted these analyses for household income.Results the probability of any use of outpatient mental health services was lower among african-american (67.4%±1.4%) and hispanic individuals (66.5%±1.5%) compared with non-hispanic white patients (72.3%±0.6%; p<0.05 for each comparison).Among those who used services, african-american and hispanic individuals had fewer mean outpatient mental health visits per year compared with non-hispanic whites (9.7±0.7 and 10.2±0.7 versus 14.3±0.5, respectively, p<0.001 for each comparison).These racial-ethnic differences in service use remained after adjustment for household income.Conclusions among young, commercially insured individuals using outpatient services following an index diagnosis of psychotic disorder, african americans and hispanics received less intensive outpatient mental health care than their non-hispanic white counterparts.Amid the upsurge of early intervention programs, special attention should be paid to increasing access to mental health services for racial-ethnic minority groups.

Journal: Psychiatric services (Washington, D.C.) (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Chemokine-Decorated Nanoparticles Target Specific Subpopulations of Primary Blood Mononuclear Leukocytes.

Specific cell targeting to deliver nanoparticles can be achieved by tailored modifications of the material surface with chemical moieties.The selection of the cell targets can be optimized by covering the nanoparticle with molecules, the receptor expression of which is restricted to particular cell subsets.Chemokines perform their biological action through 7-tm gi-protein-coupled receptors differently expressed in all tissues.We decorated the surface of biocompatible polymer nanoparticles with full-length ccl5, an inflammatory chemokine that attracts leukocytes by binding ccr5, which is highly expressed in blood-circulating monocytes.Our observations showed that ccl5 functionalization does not affect the nanoparticle biocompatibility.Notably, ccl5 nps delivered to pbmcs are selectively internalized by ccr5+monocytes but not by ccr5-lymphocytes.The efficacy of pbmc subpopulation targeting by chemokine-decorated nanoparticles establishes an easy-to-use functionalization for specific leukocyte delivery.

Journal: Nanomaterials (Basel, Switzerland) (2022)
Publication types: Journal Article
Potentially Inappropriate Medications Use among Older Adults with Comorbid Diabetes and Hypertension in an Ambulatory Care Setting.

This study aims to estimate the prevalence of pims use and its associated factors among older adults with comorbid diabetes and hypertension.Methods a cross-sectional retrospective study was used, including 1,853 older adults (age ≥65 years) with diabetes and hypertension who visited an ambulatory care setting.The study objectives were to estimate the prevalence and factors associated with pims use based on the 2019 american geriatric society (ags) beers criteria.Results almost one out of two individuals had pims used, with the average number of medications taken being seven.The most commonly prescribed pims were the use of gastrointestinal and endocrine medications.High risk of pims use was among those with ischemic heart disease, anxiety, and polypharmacy.Conclusions given the higher pims use among older adults with diabetes and hypertension comorbidities, tailored strategies and interventions to minimize pims use in this population are warranted.

Journal: Journal of diabetes research (2022)
Publication types: Journal Article