syedzayyan/paper_mill_benchmark huggingface dataset:
How to alter path dependency and promote the use of EPC model in public projects of China?

The key to promoting the epc (engineering, procurement, construction) model in china's public construction projects is to alter the path dependence of a project owner's choice of project delivery model (pdm).This study uses evolutionary game theory to discuss the mechanism of government incentives as an external motivation to alter path dependence in the pdm.In addition, a cellular automata simulation to examine the influence of various government incentives on the project owner's choice.The results show that the combination of subsidies and penalties can produce the best incentive.Subsidies are more effective at promoting pdm institutional change, whereas penalties are more effective at preventing pdm institutional change from anti-recession effects.Based on our results, we propose that the chinese government should take active subsidy measures at the initial stage of epc promotion, and adopt a dynamic incentive strategy of continuously reducing subsidies and increasing penalties according to the improvement of the development degree of epc model.

Journal: PloS one (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Chasing the conversation: Autistic experiences of speech perception.

And aims humans communicate primarily through spoken language and speech perception is a core function of the human auditory system.Among the autistic community, atypical sensory reactivity and social communication difficulties are pervasive, yet the research literature lacks in-depth self-report data on speech perception in this population.The present study aimed to elicit detailed first-person accounts of autistic individuals' abilities and difficulties perceiving the spoken word.Methods semi-structured interviews were conducted with nine autistic adults.The interview schedule addressed interviewees' experiences of speech perception, factors influencing those experiences, and responses to those experiences.Resulting interview transcripts underwent thematic analysis.The six-person study team included two autistic researchers, to reduce risk of neurotypical 'overshadowing' of autistic voices.Results most interviewees reported pronounced difficulties perceiving speech in the presence of competing sounds.They emphasised that such listening difficulties are distinct from social difficulties, though the two can add and interact.Difficulties were of several varieties, ranging from powerful auditory distraction to drowning out of voices by continuous sounds.Contributing factors encompassed not only features of the soundscape but also non-acoustic factors such as multisensory processing and social cognition.Participants also identified compounding factors, such as lack of understanding of listening difficulties.Impacts were diverse and sometimes disabling, affecting socialising, emotions, fatigue, career, and self-image.A wide array of coping mechanisms was described.Conclusions the first in-depth qualitative investigation of autistic speech-perception experiences has revealed diverse and widespread listening difficulties.These can combine with other internal, interpersonal, and societal factors to induce profound impacts.Lack of understanding of such listening difficulties - by the self, by communication partners, by institutions, and especially by clinicians - appears to be a crucial exacerbating factor.Many autistic adults have developed coping strategies to lessen speech-perception difficulties or mitigate their effects, and these are generally self-taught due to lack of clinical support.Implications there is a need for carefully designed, adequately powered confirmatory research to verify, quantify, and disentangle the various forms of listening difficulty, preferably using large samples to explore heterogeneity.More immediate benefit might be obtained through development of self-help and clinical guidance materials, and by raising awareness of autistic listening experiences and needs, among the autistic community, communication partners, institutions, and clinicians.

Journal: Autism & developmental language impairments (2022)
Publication types: Journal Article
Experimental nerve transfer model in the neonatal rat.

Clinically, peripheral nerve reconstructions in neonates are most frequently applied in brachial plexus birth injuries.Most surgical concepts, however, have investigated nerve reconstructions in adult animal models.The immature neuromuscular system reacts differently to the effects of nerve lesion and surgery and is poorly investigated due to the lack of reliable experimental models.Here, we describe an experimental forelimb model in the neonatal rat, to study these effects on both the peripheral and central nervous systems.Within 24 hours after birth, three groups were prepared: in the nerve transfer group, a lesion of the musculocutaneous nerve was reconstructed by selectively transferring the ulnar nerve.In the negative control group, the musculocutaneous nerve was divided and not reconstructed and in the positive control group, a sham surgery was performed.The animal ́s ability to adapt to nerve lesions and progressive improvement over time were depict by the bertelli test, which observes the development of grooming.Twelve weeks postoperatively, animals were fully matured and the nerve transfer successfully reinnervated their target muscles, which was indicated by muscle force, muscle weight, and cross sectional area evaluation.On the contrary, no spontaneous regeneration was found in the negative control group.In the positive control group, reference values were established.Retrograde labeling indicated that the motoneuron pool of the ulnar nerve was reduced following nerve transfer.Due to this post-axotomy motoneuron death, a diminished amount of motoneurons reinnervated the biceps muscle in the nerve transfer group, when compared to the native motoneuron pool of the musculocutaneous nerve.These findings indicate that the immature neuromuscular system behaves profoundly different than similar lesions in adult rats and explains reduced muscle force.Ultimately, pathophysiologic adaptations are inevitable.The maturing neuromuscular system, however, utilizes neonatal capacity of regeneration and seizes a variety of compensation mechanism to restore a functional extremity.The above described neonatal rat model demonstrates a constant anatomy, suitable for nerve transfers and allows all standard neuromuscular analyses.Hence, detailed investigations on the pathophysiological changes and subsequent effects of trauma on the various levels within the neuromuscular system as well as neural reorganization of the neonatal rat may be elucidated.This study was approved by the ethics committee of the medical university of vienna and the austrian ministry for research and science (bmwf-66.009/0187-wf/v/3b/2015) on march 20, 2015.

Journal: Neural regeneration research (2022)
Publication types: Journal Article
Audiovisual intervention alleviates anxiety of patients during PET/CT imaging.

To assess if the use of an audiovisual intervention in the uptake room and/or in the scanning room, could help to reduce anxiety during [18f]fdg pet/ct imaging.Methods we prospectively studied 120 patients referred for [18f]fdg pet/ct imaging.Patients were allocated in 4 groups of 30 patients depending on the use of the audiovisual intervention: (1) no audiovisual intervention; (2) audiovisual intervention only in the uptake room; (3) audiovisual intervention only in the scanning room; (4) audiovisual intervention in the uptake and the scanning rooms.In order to measure the anxiety levels of the patients before and after the scan, all patients answered the state-trait anxiety inventory (stai).Results the anxiety status across typical situations on a daily basis (stai-t) of the 4 groups of patients was comparable with no significant differences.The mean state anxiety (stai-s) sum-score at prescan and postscan among groups was: (1) 17.5±8.7 vs.17.3±8.6, p=0.834; (2) 17.4±10.5 vs.15.8±9.6, p=0.110; (3) 17.5±11.7 vs.15.1±9.8, p= 0.013; (4) 17.4±9.7 vs.14.9±8.1, p= 0.009.The percentage of patients with reduction of the stai-s score among groups 1-4 was 17%, 47%, 50%, and 66%, respectively.The variation of the percentage of patients with lower scores after intervention among groups was statistically significant (p<0.001).Conclusion audiovisual intervention decreases anxiety levels of patients referred for pet/ct imaging.The results of our study support a beneficial effect of the audiovisual intervention and its potential to alleviate the anxiety of oncological patients who undergo a pet/ct scan.

Journal: Nuklearmedizin. Nuclear medicine (2022)
Publication types: Journal Article
Carbon ion (12C6+) irradiation induces the expression of Klrk1 in lung cancer and optimizes the tumor microenvironment based on the NKG2D/NKG2D-Ls pathway.

With the identification of "negative immune regulation" defects in the immune system and the continuous improvement of immunotherapy, natural killer cells (nk) have received more attention, especially as tools in combined immunotherapy.Carbon ions (12c6+) have become the ideal radiation for combined immunotherapy due to their significant radiobiological advantages and synergistic effects.The purpose of this study was to explore the nk cell-mediated cytotoxicity pathway and related mechanisms in lung cancer induced by carbon ion irradiation.Klrk1, which specifically encodes the nkg2d receptor, was significantly correlated with the prognosis, clinical stage, functional status of nk cells, and the immune microenvironment of lung cancer, as shown by bioinformatics analysis.Based on rna-seq data of lewis lung cancer in c57bl/6 mice, carbon ion irradiation was found to significantly induce klrk1 gene expression and activate the nkg2d/nkg2d-ls pathway.The treg inhibition pathway combined with carbon ion radiotherapy could significantly increase the infiltration and function of nk cells in the tumor microenvironment of lung cancer and prolong the survival time of c57bl/6 mice.In conclusion, carbon ions have significant radiobiological advantages, especially under conditions of combined immunotherapy.Carbon ions combined with treg inhibitors can significantly improve the infiltration and functional status of nk cells.

Journal: Cancer letters (2021)
Publication types: Journal Article
Whole body vibration and rider comfort determination of an electric two-wheeler test rig.

Two-wheeled vehicles are the major mode of transportation in india.Such vehicles are exposed to excessive vibration on the road when compared to four-wheeled vehicles.However, the research on the reduction of whole body vibration in the case of two-wheelers is not explored in detail.The present study predicts rider comfort in the case of an electric two-wheeler as per iso 2631-1, by obtaining the finding the weighted acceleration at the strategic locations of vibration at the test rig.Methods an electric two-wheeler test rig is used in the study.The values of acceleration from the test rig in running conditions are obtained by using ni lab view 2019.The drive cycle of the electric vehicle (ev) test rig is controlled by sync sols' ev lab software.Obtaining the weighted root mean square (rms) acceleration from running the test setup, it is compared with the iso 2631-1 standard to obtain the rider comfort.Results loading area, traction motor, base mount, and suspension were found to be the strategic points of vibration.Frequency weighted rms acceleration of 0.3 to 0.4 m/s2obtained at these points are prone to cause discomfort for the rider.Vehicle speed, road profile, and duration of exposure were found to be important parameters affecting the rider's comfort.A maximum of 4.6 m/s2amplitude was observed.The loading area, which corresponds to a rider's seat in actual vehicle, is important and reduction of these vibrations make the ride comfortable for the rider.Suspension and base mount of the test rig are found to be uncomfortable observing the weighted rms acceleration.Conclusions a suitable damping technique design is very much essential in reducing these vibrations and improve the rider comfort, as many more non-deterministic vibrations are prone to cause dis-comfort in case of actual on road riding conditions.

Journal: F1000Research (2023)
Publication types: Journal Article
Simultaneous determination of lidocaine and its active metabolites in plasma by UPLC-MS/MS and application to a clinical pharmacokinetic study in liver cancer patients with laparoscopic hepatectomy.

Lidocaine, widely used as a local anesthetic, has anti-inflammatory and inhibitory effects on tumor recurrence and metastasis.To investigate the pharmacokinetics of lidocaine in liver cancer patients undergoing laparoscopic hepatectomy, a fast and sensitive analytical technique was developed.The method was adequately validated with ultra-performance liquid chromatography-tandem mass spectrometry (uplc-ms/ms) to simultaneously determine the concentration of lidocaine and its metabolites in plasma.The chromatographic separation was achieved on an acquity uplc beh c18column (2.1 × 50 mm, 1.7 μm) by gradient elution with a mobile phase of a (formic acid-water (1:1000, v/v)) and b (formic acid-acetonitrile (1:1000, v/v)).The accuracy and precision were verified within the concentration ranges of 10-5000 ng/m l for lidocaine, 2-1000 ng/m l for monoethylglycinexylidide (megx) and 2-500 ng/m l for glycinexylidide (gx).The selectivity, carry-over effect, interference between the analytes and internal standard (is), precision and accuracy, matrix effect extraction recovery, dilution integrity and stability were satisfactory for the relevant guideline standards.The method was successfully applied to the pharmacokinetic study of lidocaine in liver cancer patients undergoing laparoscopic hepatectomy.After receiving a bolus and continuous infusion, the mean peak concentration of lidocaine was 2097 ng/m l for lidocaine, 336.6 ng/m l for megx and 72.66 ng/m l for gx, respectively.The mean peak time was 2.89 h for lidocaine, 5.14 h for megx and 9.88 h for gx, respectively.In addition, the mean half-life was 4.19 h for lidocaine and 6.92 h for megx.In this study, we found that the metabolism of lidocaine and megx might be affected by the hepatic blood flow occlusion or liver injury.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (2022)
Publication types: Journal Article
Investigation of High-Resolution Distributed Fiber Sensing System Embedded in Flexible Silicone Carpet for 2D Pressure Mapping.

Fiber-optic sensors are a powerful tool to investigate physical properties like temperature, strain, and pressure.Such properties make these sensors interesting for many applications including biomedical applications.Fiber sensors are also a great platform for distributed sensing by using the principles of optical frequency domain reflectometry.Distributed sensing is becoming more and more used to achieve high-resolution measurements and to map physical properties of biomaterials at small scale, thus obtaining 2d and 3d mapping of a particular area of interest.This work aims at building and investigating a 2d sensing carpet based on a distributed fiber sensing technique, to map local pressure applied to the carpet.The two-dimensional mapping is obtained by embedding a single-mode optical fiber inside a soft silicone carpet.The fiber has been bent and arranged in a specific configuration characterized by several parallel lines.Different fiber fixation methods have been investigated by means of a comparative analysis to perform better characterization and to achieve a more precise response of the carpet.The best pressure sensitivity coefficient (0.373 pm/k pa or considering our setup 1.165 nm/kg) was detected when the fiber was fully embedded inside the silicone carpet.This paper demonstrates the possibility of mapping a 2d distributed pressure over a surface with a resolution of 2 mm by 2 mm.The surface of investigation is 2 cm by 6 cm, containing 310 sensing points.The sensing carpet has been validated selecting several preferential positions, by testing the consistency of the results over different portions of the carpet.

Journal: Sensors (Basel, Switzerland) (2022)
Publication types: Journal Article
Neuroprotective Effect of Baicalein Against Oxaliplatin-Induced Peripheral Neuropathy: Impact on Oxidative Stress, Neuro-inflammation and WNT/β-Catenin Signaling.

Oxaliplatin, an effective anti-cancer agent used in the treatment of colorectal cancer, is associated with severe dose-limiting side effects like peripheral neuropathy, which currently remains a major unmet clinical need.This study was designed to investigate the possible neuroprotective potential of a bioflavonoid, baicalein in an experimental model of oxaliplatin-induced peripheral neuropathy.Rats were administered with a dose of 4 mg/kg oxaliplatin i.p.Twice per week for four weeks, and were evaluated for behavioral and functional nerve parameters, followed by biochemical, immunohistochemical and western blot analysis.This study shows that baicalein reversed oxaliplatin-induced behavioral deficits and significantly prevented oxaliplatin-induced sensory nerve conduction deficits in rats.Molecular analysis revealed baicalein significantly strengthened the antioxidant defense system by enhancing the expression of mn sod, ho-1, and gsh levels.Baicalein treatment neutralized the oxaliplatin-induced neuroinflammation, which was evident from the significant loss of inflammatory mediators like tnf-α, il-6 and a shunted nf-κb nuclear translocation.Additionally, baicalein treatment resulted in a significant downregulation of active β-catenin, wnt5b and wnt3a proteins.In line with the in vivo evidences, baicalein treatment in neuro2a cells attenuated oxaliplatin-induced ros, mitochondrial superoxide levels and improved neuritogenesis.Additionally, baicalein did not alter the cell viability of oxaliplatin in hct-116 cell line.Collectively, these results suggest that baicalein may be useful for management of peripheral neuropathy associated with oxaliplatin.

Journal: Molecular neurobiology (2022)
Publication types: Journal Article
Assessment of Hand Hygiene Practices of University Students in Vietnam Amid the COVID-19 Pandemic: A Brief Report.

Effective handwashing practices help prevent the spread of coronavirus disease 2019 (covid-19).This study examined the knowledge, frequency, and characteristics of handwashing practices among vietnamese university students.Methods an analytic cross-sectional study was conducted on all students enrolling at phenikaa university in vietnam.A self-developed questionnaire was used to collect information on the participants' knowledge regarding the effectiveness of handwashing as a covid-19 preventive measure, the moments for hand hygiene, the most appropriate practices in different situations, and frequency.Results among 728 study participants, 460 (63.2%) were from health-related faculties.Almost (97.9%; 713/728) all participants knew that handwashing could protect against the spread of infection, but less than half performed handwashing often in a normal day (47.4%; 345/728), after sneezing or coughing (48.9%; 356/728), and 7.4% (54/728) only washed hands when hands are visibly dirty.Health students used alcohol-based handrub in all situations, including those requiring handwashing with water and soap (p< 0.05).Conclusions the levels of knowledge regarding the effectiveness of handwashing among study participants are high, but actual practices of handwashing are suboptimal.It is crucial to improve community education to help reinforce correct hand hygiene behaviors, including when to wash hands and which method should be used.

Journal: Disaster medicine and public health preparedness (2022)
Publication types: Journal Article
Arthroscopic Treatment of Calcific Tendinitis of Gemellus Superior and Gemellus Inferior: A Case Report and Literature Review.

Tendon calcification is a common disease, and it could happen in the tendons of the shoulder, wrist, etc.However, tendon calcification in the superior and inferior gemellus is rare, and in this region is likely to be misdiagnosed.Case presentation here, our case report first reported a 53-year-old female patient with an unusual case of calcific tendinitis of the gemellus superior and gemellus inferior muscles.The patient presented with severe pain in the right hip and lower extremities, not relieved using nonsteroidal anti-inflammatory drugs (nsaids).The preoperative physical examination indicated an abnormality in the hip joint.Preoperative imaging confirmed the results of the physical examination and showed a right hip lesion.We did not make a definite diagnosis preoperatively but considered that the patient might have an osteochondroma.However, surgical findings indicated that the lesion was not in the hip capsule on subsequent arthroscopic surgery, which suggested that the preoperative diagnosis might be wrong.We opened the posterior capsule and found a "toothpaste-like" lesion in the superior and inferior gemellus muscles' tendon.We thought this might be the calcified tendon.Then the arthroscopic surgery was finished to remove the lesion, and the removed tissue was sent to the pathology department for pathological examination.The pathological report confirmed the diagnosis of the calcified tendon.Postoperative follow-up was conducted.The effect of the operation was noticeable.Postoperative symptoms were relieved.Conclusions calcification of the tendons of the superior and inferior gemellus muscles can be easily misdiagnosed, and the disease can be treated minimally with arthroscopy.

Journal: Orthopaedic surgery (2022)
Publication types: Case Reports;Review;Journal Article
Factors influencing surgical outcomes of laparoscopic myomectomy. A propensity-score matched analysis.

Introduction to evaluate factors influencing surgical choice in performing uterine myomectomy by comparing laparoscopic and open approach surgery.Material and methods we analyzed women undergoing uterine myomectomy in our hospital.Patients were divided into two groups: patients who underwent laparoscopic myomectomy (group a) and patients who underwent laparotomic myomectomy (group b).We matched 1 : 1 women in these two groups to compare the effects of the procedures on each outcome according to a propensity-matched score analysis.Results 460 myomectomies were performed in the study period: 361 cases by laparoscopy (group a) and 99 cases by laparotomy (group b).We found lower estimated intraoperative blood loss (200 ml group a vs.300 ml group b, 8 cm and association with the presence of more than 2 myomas.Conclusions despite some proposals from previous studies, there are no specific guidelines regarding the best surgical procedure for myomectomy.Our data confirm that the choice of surgical technique should consider the patient characteristics and the surgeon experience to reduce longer operating times and more significant blood loss.

Journal: Przeglad menopauzalny = Menopause review (2022)
Publication types: Journal Article