syedzayyan/paper_mill_benchmark huggingface dataset:
Effects of Ulinastatin on Myocardial Ischemia-Reperfusion Injury, Cardiac Function, and Serum TNF-α and IL-10 Levels in Patients Undergoing Cardiac Valve Replacement under Cardiopulmonary Bypass

Myocardial ischemia-reperfusion injury (miri) is a very common adverse reaction after cardiac valve replacement (cvr) under cardiopulmonary bypass, which seriously affects the rehabilitation and prognosis of patients.Objective.The prevention and treatment of miri are a hotspot of modern medical research, and this study is aimed at providing reliable reference and guidance for future clinical prevention and treatment of miri by analyzing the effects of ulinastatin (ul) on cardiac function and miri of patients after cvr.Methods.A total of 104 patients undergoing cvr under cardiopulmonary bypass in our hospital were selected as research participants.Among them, 52 patients treated with ul were assigned to the observation group, and the rest 52 patients given the same amount of normal saline were assigned to the control group.The cardiopulmonary bypass status, postoperative status, cardiac function, inflammatory response, oxidative stress response, and hemodynamics were observed and compared between the two groups.In addition, clinical efficacy and safety and patient prognosis were compared.Results.Through experimental analysis, we found that ul had no significant effect on the clinical efficacy, safety, and prognosis of patients after surgery ( p &gt; 0.05 ) but had obvious protective effects on cardiopulmonary bypass status, cardiac function, inflammation, oxidative stress, and hemodynamics ( p &lt; 0.05 ).Conclusion.Ul can effectively prevent the occurrence of miri after cvr under cardiopulmonary bypass, which is worthy of clinical application.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Effects of Modified Sang ju-Yin Decoction Combined with IFNαlb Nebulization on IL-1β and HBD2 in Children with Asthmatic Bronchitis

Breathing disease swelling of the lung tubes caused by viral infection is more and more likely to develop into related to the lung tubes breathing disease, especially repeating breathing loudly.Objective.To investigate the effect of modified sang ju-yin decoction combined with interferon (ifn)αlb nebulization on children with asthmatic bronchitis and the effects of il-1β and β-defensin 2 (hbd2).Materials and methods.The clinical data of 80 children with asthmatic bronchitis who were diagnosed and treated in our hospital from may 2019 to may 2021 were selected as the research objects and divided into the control group and the observation group with 40 cases in each group according to different treatment methods.Among them, the control group was nebulized with ifnαlb, and the observation group was given addition and subtraction of sang ju-yin decoction based on the control group.The clinical symptoms, pulmonary function indexes, adverse reactions, and effects on serum inflammatory indexes were observed and compared between the two groups.Results.There was no significant difference in the scores of symptoms and signs between the two groups before treatment ( p &gt; 0.05 ), while the scores of shortness of breath, cough, stridor, lung rales, and signs after treatment of observation group were better than those of the control group ( p &lt; 0.05 ).There was no significant difference in serum inflammatory indexes and pulmonary function indexes between the two groups before treatment ( p &gt; 0.05 ), while the differences in il-6, il-10, tnf-α, il-1β, and hbd2 after treatment were significant between the two groups ( p &lt; 0.05 ).After treatment, the rr, tv, and pef indexes of the two groups of children were significantly improved ( p &lt; 0.05 ).After treatment, the adverse reaction rate of liver function damage, dry throat discomfort, rash, nausea, and vomiting in the observation group was 7.5%, which was significantly lower than 27.5% in the control group ( p &lt; 0.05 ).Conclusion.Modified sang ju-yin decoction combined with ifnαlb nebulization can improve symptoms and promote the recovery of patients in the treatment of acute bronchitis.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Effects of Modified Duhuo Jisheng Decoction Combined with Arthroscopic Surgery on Bone Metabolism, Oxidative Stress, and Serum TLR4 and TGF-iβ/i1 in Patients with Knee Osteoarthritis

To analyze the effects of modified duhuo jisheng decoction combined with arthroscopic surgery on bone metabolism, oxidative stress, and serum tlr4 and tgf‐ β 1 in patients with knee osteoarthritis (koa).Methods .Prospectively select 82 patients with koa from january 2020 to january 2022 in our hospital and divide them into the control group and observation group according to the random number table method, with 41 patients in each group.The control group was treated with arthroscopic surgery alone and routine anti‐infection after operation.The observation group was treated with duhuo jisheng decoction on the basis of the treatment of the control group.The patients in the two groups were treated continuously for 4 weeks.The improvement of patients’ symptoms was evaluated by the western ontario and mc master universities osteoarthritis index (womac).Before treatment and 4 weeks after treatment, the scores of traditional chinese medicine (tcm) symptoms, bone metabolism indicators (cartilage oligomeric matrix protein (comp), collagen type ii carboxy terminal peptide (ctx‐ii), and matrix metalloproteinase‐3 (mmp‐3)), oxidative stress indicators (superoxide dismutase (sod), glutathione peroxidase (gshpx), malondialdehyde (mda), nitric oxide (no)), serum toll‐like receptor 4 (tlr4), and transforming growth factor β (tgf‐ β ) level were compared between the two groups.Results .After treatment, the womac score of the two groups decreased (42.45 ± 10.83) in the observation group and (67.81 ± 14.63) in the control group.The womac score of the observation group was lower than that of the control group ( p &lt; 0.05).After treatment, the levels of comp, ctx‐ii, and mmp‐3 in the two groups decreased, and the levels of comp, ctx‐ii, and mmp‐3 in the observation group were lower than those in the control group ( p &lt; 0.05).After treatment, the levels of sod and gshpx increased, while the levels of mda and no decreased in the two groups.The levels of sod and gshpx in the observation group were higher than those in the control group, while the levels of mda and no were lower than those in the control group ( p &lt; 0.05).After treatment, the tlr4 level in the observation group was lower than that of the control group, and the level of tgf‐ β in the observation group was higher than that of the control group ( p &lt; 0.05).Conclusion .Compared with arthroscopic surgery alone, combined with modified duhuo jisheng decoction can better alleviate the clinical symptoms of patients with koa, improve their bone metabolism, oxidative stress indicators, and serum tlr4 and tgf‐ β 1 level, and reduce the inflammatory injury of knee joint.

Journal: Journal of Environmental and Public Health (2022)
Publication types: Research Article;
Effects of Gemcitabine and Oxaliplatin Combined with Apatinib on Immune Function and Levels of SIL-2R and sicAM-1 in Patients with Gallbladder Cancer

The aim of this study was to determine how gemcitabine, oxaliplatin combination, and apatinib affect immune function and sil-2r and sic am-1 levels in patients with gallbladder cancer.Methods.Retrospective analysis of 116 patients with gallbladder cancer treated at our institution between february 2019 and february 2021.The patients were randomly divided into control and study groups, with 58 patients in each group.The study group received the combination of apatinib and the control group received gemcitabine and oxaliplatin.Immune function, serum tumor markers, short-term efficacy, survival measures, and incidence of adverse events were monitored and compared between the two groups.Results.Cd3+, cd4+, cd4+/cd8+, and nk levels were significantly higher in both groups after treatment, while cd8+ levels were significantly lower; levels of sic am-1, sic am-1 (vegf), and cea were greatly reduced in both groups after treatment; there were significant differences between the study and control groups in terms of rr46.55% and dcr84.48%; at one year after treatment, the survival rate in the study group increased from 67.24% in the control group to 79.31%, with an increase in both pfs and 0s.Compared with the control group, the incidence of hypertension and myelosuppression, neutropenia, proteinuria, and hand-foot syndrome were lower in the study group ( p &lt; 0.05 ).All differences were statistically significant.Conclusion.In the treatment of gallbladder cancer, the use of gemcitabine and oxaliplatin combined with apatinib can effectively control the progression of patients’ disease.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Clinical Study;
Mathematical Modeling and Simulation of Wireless Sensor Network Coverage Problem

The research on wireless sensor networks has achieved a lot in recent years and some of the results have been put into practical applications, but with the increasing demand and requirements for wireless sensor networks, many old and new problems need to be solved urgently.In this paper, a data topology optimization algorithm based on local tree reconstruction for heterogeneous wireless sensor networks is proposed for data transmission in wireless sensor networks that are easily affected by external instabilities.This heterogeneous network can accomplish better data transmission; firstly, the nodes are divided into different layers according to the hop count of nodes in the network, and a certain proportion of relay nodes are selected for different layer nodes; then, different initial energy is set for different layer nodes, and since the data packets of different nodes have different sizes, the corresponding data aggregation coefficients are used in this paper according to the actual data requirements of the network during data transmission; finally, the topology of the tree is dynamically updated in real time during the operation of the network to extend the lifetime of the nodes.The simulation results verify that the proposed heterogeneous network topology evolution algorithm effectively extends the network lifetime and improves the utilization of nodes.This paper establishes a modified least‐squares target localization model to achieve accurate 3d localization of targets in real scenes and proposes an optimal base station node selection strategy based on spectral clustering using the location distribution information of base station nodes in space.The simulation results show that the error of the terminal 3d coordinates calculated by the proposed algorithm is smaller than the real coordinates, and the error is smaller than other existing algorithms with the same simulation data.

Journal: Wireless Communications and Mobile Computing (2021)
Publication types: Research Article;
Effects of Dexmedetomidine on Hemodynamics and Anesthesia Effect of Different Doses of General Anesthesia in Patients Undergoing Hepatobiliary Surgery

In order to provide corresponding anesthesia methods of hepatobiliary diseases and obtain better clinical effect, the hemodynamics and clinical efficacy are evaluated by using different doses of dexamethasone (dex) during the operation.97 patients undergoing general anesthesia for hepatobiliary surgery in our hospital from april 2020 to august 2021 are analyzed retrospectively.All patients are divided into g1 ( n = 24), g2 ( n = 24), g3 ( n = 24), and control group ( n = 25) according to the random number table method.The g1, g2, and g3 groups are injected with dex 1.0 ug/kg, dex 0.8 ug/kg, and dex 0.5 ug/kg by intravenous infusion pump before induction of general anesthesia, and the control group is injected with 0.9%nacl solution 10 m l.Intraoperative anesthesia time, postoperative eye opening time, and extubation time of all groups are observed, and the incidences of postoperative adverse reactions are compared.The experimental results show that during general anesthesia in the liver and gallbladder surgery, the patients with high dose of dex can better maintain the intraoperative hemodynamic parameters, and effectively restrain the postoperative stress reaction.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Clinical Study;
Application of Modern Multimedia and Sensing Technology in Fault Detection and Diagnosis of Hydraulic Agricultural Machinery

In order to solve the problem of fault diagnosis of agricultural machinery hydraulic system, the authors propose an application of modern multimedia and sensing technology in fault detection and diagnosis of hydraulic agricultural machinery.By analyzing the component faults and system faults of the hydraulic system of agricultural machinery, an expert system for fault diagnosis is constructed, and a knowledge base and inference engine suitable for fault diagnosis of the hydraulic system of agricultural machinery are designed.In order to further improve the diagnostic accuracy of the fault diagnosis expert system, a fault diagnosis based on sparse coding is designed, and the sparse coding fault diagnosis results are integrated with the expert system to improve the diagnostic accuracy.The experimental results show that after sparse coding fusion, the fault diagnosis accuracy can be improved to more than 91%.In conclusion, the model meets the requirements of fault diagnosis and puts forward a new idea for the fault diagnosis of agricultural machinery hydraulic system.Make the agricultural machinery and equipment industry develop healthily.

Journal: Wireless Communications and Mobile Computing (2022)
Publication types: Research Article;
Long non-coding RNA KCNQ1OT1 Promotes the Progression of Gastric Cancer via the miR-145-5p/ARF6 Axis

Background long non‐coding rna kcnq1 opposite strand/antisense transcript one gene (kcnq1ot1) has been reported to be involved in the progression of many types of human cancer, whereas its role in gastric cancer (gc) remains unknown.The present study aimed to investigate the role of kcnq1ot1 in gc.Methods in total, 25 gc tissues and adjacent normal tissues were collected.The expression of kcnq1ot1, mi r‐145‐5p and arf6 in gc tissues and cell lines was detected by quantitative reverse transcriptase‐polymerase chain reaction or western blotting.Bioinformatics analysis and a dual luciferase reporter assay were performed to determine the relationship between kcnq1ot1 and mi r‐145‐5p or mi r‐145‐5p and arf6.Gain‐ and loss‐of function of kcnq1ot1 and mi r‐145‐5p were achieved to confirm their roles in gc cells.Cell counting kit‐8, colony formation and flow cytometry assays were used to evaluate cell viability, proliferation and apoptosis.A xenograft tumor model was established with bgc803 tumor cells transfected with sh‐kcnq1ot1 or empty vector to determine the role of linc01089 in vivo .Results the expression levels of kcnq1ot1 were markedly elevated in gc tissues and cells.Knockdown of kcnq1ot1 inhibited gc tumor growth, reduced gc cell viability and colony formation, and induced gc cell apoptosis.The expression levels of mi r‐145‐5p were significantly decreased in gc cells and correlated with the expression of kcnq1ot1 in gc tumors.Moreover, kcnq1ot1 directly binds with mi r‐145‐5p, which is targeting arf6.Knockdown of kcnq1ot1 increased the expression levels of mi r‐145‐5p.Inhibition of mi r‐145‐5p increased the expression levels of kcnq1ot1 and also attenuated the effects of knockdown of kcnq1ot1 on the viability, proliferation and apoptosis of gc cells.In addition, overexpression of mi r‐145‐5p reduced gc cell viability and colony formation and induced gc cell apoptosis, whereas overexpression of arf6 attenuated the effects of overexpression of mi r‐145‐5p on gc cell viability, colony formation and apoptosis.Conclusions kcnq1ot1 can promote gc progression through the mi r‐145‐5p/arf6 axis.Kcnq1ot1 may serve as a therapeutic target and a diagnostic biomarker of gc.

Journal: The Journal of Gene Medicine (2021)
Publication types: Research Article;
Effects of Comprehensive Nursing Based on Orem’s Self-Care Theory on Symptom Improvement and Pregnancy Outcome in Patients with Antiphospholipid Syndrome: A Retrospective Cohort Study

A retrospective cohort study was conducted to explore the effects of comprehensive nursing based on orem’s self-care theory on symptom improvement and pregnancy outcomes in patients with antiphospholipid syndrome (aps).Methods.Sixty patients with antiphospholipid antibody syndrome treated in our hospital from february 2019 to april 2021 were enrolled.The control group received comprehensive nursing, while the study group received comprehensive nursing based on orem’s self-care theory.Nursing satisfaction, self-nursing ability, anxiety score, social support status, pregnancy outcome, and the score of life quality were compared between the two groups.Results.First of all, we compared the nursing satisfaction, the study group was very satisfied in 23 cases, satisfactory in 5 cases, general in 2 cases, the satisfaction rate was 100.00%.While in the control group, 11 cases were very satisfied, 10 cases were satisfied, 4 cases were general, and 5 cases were dissatisfied, the satisfaction rate was 83.33%.The nursing satisfaction in the study group was higher compared to the control group ( p &lt; 0.05 ).Secondly, the self-concept, sense of self-care responsibility, self-nursing skills, health knowledge, and total score of the study group were higher compared to the control group ( p &lt; 0.05 ).After intervention, the anxiety scores of the two groups decreased.Compared between the two groups, the anxiety scores of the study group before intervention and 1 week, 2 weeks, 3 weeks, and 4 weeks after intervention were lower compared to the control group ( p &lt; 0.05 ).The comparison of social support showed that the scores of objective support, subjective support, utilization of support, and total score of social support in the study group were higher compared to the control group ( p &lt; 0.05 ).The number of abortions in the control group was lower compared to the control group, and the number of full-term deliveries was higher compared to the control group ( p &lt; 0.05 ).Finally, we compared the scores of life quality.After nursing, the scores of life quality of the two groups increased.Of note, the scores of physiological function, psychological function, social function, and health self-cognition in the study group were lower compared to the control group ( p &lt; 0.05 ).Conclusion.Comprehensive nursing for patients with aps based on orem’s self-care theory can effectively improve clinical symptoms and pregnancy outcome and play a positive role in facilitating patients’ nursing satisfaction and self-nursing ability, which can also effectively strengthen mental health and social support, this nursing model is worth popularizing in clinic.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Evaluation of Vertebral Function and Long-Term Quality of Life after Percutaneous Minimally Invasive Surgery in Patients with Thoracolumbar Spine Fractures

To investigate the changes in vertebral function after minimally invasive surgery in patients with thoracolumbar spinal fractures and investigate the impact of percutaneous minimally invasive surgery on patients’ quality of life by following up the patients in the long term.Methods.A retrospective analysis was performed to select 80 patients with thoracolumbar spinal fractures treated in our hospital from april 2013 to october 2018, and the patients were divided into a study group and a control group according to the difference in their choice of procedure.The two groups were compared in terms of perioperative wound pain, serum creatine kinase (ck) activity, and c-reactive protein (crp) levels, and the two groups were followed up for 2 years to compare the changes in anterior vertebral body height and cobb’s angle during the follow-up period and to compare the differences in quality of life between the two groups.Results.(1) the pain level of patients in the study group was significantly lower than that of the control group at the 1st and 3rd postoperative days ( p &lt; 0.05 ).(2) the ck activity and cpr level of patients in the study group were significantly lower than that of the control group at the 1st and 3rd postoperative days ( p &lt; 0.05 ).(3) compared with the preoperative period, the height of the anterior border of the vertebral body and the cobb’s angle in both groups showed significant changes at 7 d, 6 months, one year, and two years after surgery ( p &lt; 0.05 ), suggesting that both procedures can significantly restore the height of the injured vertebra and improve the function of the vertebral body.(4) the somatic, physical, and psychological functions of patients in the study group were significantly greater than those in the control group at 6 months postoperatively ( p &gt; 0.05 ).Conclusion.Compared to traditional open surgery, minimally invasive percutaneous surgery for thoracolumbar fractures can significantly reduce perioperative pain and improve perioperative stress in patients, while achieving better surgical outcomes and a significantly improved quality of life in patients at long-term follow-up.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;
Estimation of Soft and Hard Tissue Revolutionization Surrounding Dental Implant: A 2-Year Retrospective Study

A dental implant is an idyllic mode of operandi for oral rehabilitation for complete and partially edentulous patients.The success of an implant is based on the health of its surrounding tissues.Therefore, the biological and clinical aspects of implant prosthesis and their surrounding tissues must persist to be investigated.A two-year retrospective clinical-radiological study was conducted to estimate peri-implant soft and hard tissue revolutionization after the placement of implants.A clinical-radiological investigation was carried out to determine the amount of soft and hard tissue revolutionization that occurred following the implantation of 200 implants.From october 2020 to march 2021, the research was carried out in the college of dentistry at king khalid university in saudi arabia.It was decided to conduct this study using a retrospective clinical record, which involved gathering information about patients who had previously received dental implants within the previous two years.Plaque index (pi), gingival index (gi), bleeding index (bi), peri-implant probing depth (pd), and peri-implant crestal bone level were measured at baseline and three months after implant placement in adult patients ranging in age from 20 to 50 years.The results were compared to the full-mouth index (fmi).Ethical clearance and written informed consent were obtained from all the study participants.The statistical analysis was done by using statistical package for social sciences (spss-23.0 version) (ibm; chicago).The present study concluded that plaque accumulation, gingival bleeding, and probing depth were increased around implants during the follow-up, but it would not affect crestal bone loss.Still, it is essential to conduct a similar study with a larger sample size and a long follow-up period to give more precise results.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;