syedzayyan/paper_mill_benchmark huggingface dataset:
Novel TRPV1 Modulators with Reduced Pungency Induce Analgesic Effects in Mice.

Capsaicin, the compound in hot chili peppers responsible for their pungency and an agonist of the transient receptor potential cation channel, subfamily v, member 1 (trpv1), has long been known to promote the desensitization of nociceptors at high concentrations.This has led to the utilization and implementation of topical capsaicin cream as an analgesic to treat acute and chronic pain.Critically, the application of capsaicin cream is limited due to capsaicin's high pungency, which is experienced prior to analgesia.To combat this issue, novel capsaicin analogues were developed to provide analgesia with reduced pungency.Analogues reported in this paper add to and show some differences from previous structure-activity relationship (sar) studies of capsaicin-like molecules against trpv1, including the necessity of phenol in the aromatic "a-region", the secondary amide in the "b-region", and modifications in the hydrophobic "c-region".This provided a new framework forde novosmall-molecule design using capsaicin as the starting point.In this study, we describe the synthesis of capsaicin analogues, theirin vitroactivity in ca2+assays, and initialin vivopungency and feasibility studies of capsaicin analogues yb-11 and yb-16 as analgesics.Our results demonstrate that male and female mice treated with yb capsaicin analogues showed diminished pain-associated behavior in the spontaneous formalin assay as well as reduced thermal sensitivity in the hotplate assay.

Journal: ACS omega (2022)
Publication types: Journal Article
Transparent human - (non-) transparent technology? The Janus-faced call for transparency in AI-based health care technologies.

The use of artificial intelligence and big data in health care opens up new opportunities for the measurement of the human.Their application aims not only at gathering more and better data points but also at doing it less invasive.With this change in health care towards its extension to almost all areas of life and its increasing invisibility and opacity, new questions of transparency arise.While the complex human-machine interactions involved in deploying and using ai tend to become non-transparent, the use of these technologies makes the patient seemingly transparent.Papers on the ethical implementation of ai plead for transparency but neglect the factor of the "transparent patient" as intertwined with ai.Transparency in this regard appears to be janus-faced: the precondition for receiving help - e.g., treatment advice regarding the own health - is to become transparent for the digitized health care system.That is, for instance, to donate data and become visible to the ai and its operators.The paper reflects on this entanglement of transparent patients and (non-) transparent technology.It argues that transparency regarding both ai and humans is not an ethical principle per se but an infraethical concept.Further, it is no sufficient basis for avoiding harm and human dignity violations.Rather, transparency must be enriched by intelligibility following judith butler's use of the term.Intelligibility is understood as an epistemological presupposition for recognition and the ensuing humane treatment.Finally, the paper highlights ways to testify intelligibility in dealing with ai in health care ex ante, ex post, and continuously.

Journal: Frontiers in genetics (2022)
Publication types: Journal Article
Constant-Power versus Constant-Voltage Actuation in Frequency Sweeps for Acoustofluidic Applications.

Supplying a piezoelectric transducer with constant voltage or constant power during a frequency sweep can lead to different results in the determination of the acoustofluidic resonance frequencies, which are observed when studying the acoustophoretic displacements and velocities of particles suspended in a liquid-filled microchannel.In this work, three cases are considered: (1) constant input voltage into the power amplifier, (2) constant voltage across the piezoelectric transducer, and (3) constant average power dissipation in the transducer.For each case, the measured and the simulated responses are compared, and good agreement is obtained.It is shown that case 1, the simplest and most frequently used approach, is largely affected by the impedance of the used amplifier and wiring, so it is therefore not suitable for a reproducible characterization of the intrinsic properties of the acoustofluidic device.Case 2 strongly favors resonances at frequencies yielding the lowest impedance of the piezoelectric transducer, so small details in the acoustic response at frequencies far from the transducer resonance can easily be missed.Case 3 provides the most reliable approach, revealing both the resonant frequency, where the power-efficiency is the highest, as well as other secondary resonances across the spectrum.

Journal: Micromachines (2022)
Publication types: Journal Article
Isolation, screening, preliminary optimisation and characterisation of thermostable xylanase production under submerged fermentation by fungi in Durban, South Africa.

Fungi are renowned for their ability to produce extracellular enzymes into their surrounding environment.Xylanases are hydrolytic enzymes capable of xylan degradation.The objectives of this study were to isolate, screen for potential xylanolytic fungi from soil and tree bark samples from three locations in south africa and to determine their growth conditions for maximum xylanase production.Forty-six isolates were obtained based on clearing zone formation on xylan-enriched agar plates using congo red indicator.Xylanase activity was quantified during submerged fermentation.Isolate ms5, identified as trichoderma harzianumwith the highest enzyme activity (38.17 u/ml) was selected for further studies based on thermophilic properties (70°c) and p h (5.0).The culture conditions; incubation period (5 days), agitation speed (160 rpm) wheat bran (1%) and ammonium sulphate (1.2%) were optimised further.Biochemical characterisation of the crude enzyme revealed two p h and temperature optima (p h 6.0 at 60°c and 70°c, p h 8.0 at 55°c and 75°c).The enzyme retained >70% activity after 4 h at p h 6.0 at 70°c.Sds-page revealed multiple protein bands with a prominent band at 70 k da.Substrate native page revealed multiple isoforms between 55 and 130 k da.This enzyme will be beneficial for applications in the animal feed and biofuels industries.

Journal: Mycology (2022)
Publication types: Journal Article
An overview of allergens.

Most allergens are proteins or glycoproteins that range in molecular weight from 5000 to 100,000 da, although polysaccharides and low-molecular-weight substances may also be allergenic.Common allergens include pollens, fungal spores, house-dust mites, and animal epithelial materials but can also include drugs, biologic products, and insect venoms.The allergic response is dependent on the route of exposure.If the exposure is to an inhaled aeroallergen, then the allergic response will be respiratory in nature.Ingested or injected exposure gives rise to gastrointestinal, cutaneous, or anaphylactic reactions.The size of the pollen determines the clinical manifestation of allergy.For example, particles between 20 and 60 μm in diameter can be carried by the wind and cause nasal and ocular symptoms (allergic rhinoconjunctivitis).Particles of <7 μm can deposit in the airways and cause symptoms of asthma.Animals produce allergens in forms unique to each species.Cat allergen, most importantly fel d 1, is buoyant and "sticky," which means it easily remains airborne and may last in a home for up to 6 to 9 months after the source is removed.Cat allergen adheres to clothes and can be found in public places, e.g., schools.Dog allergen, particularly can f 1, is present in dander, saliva, urine, and serum.All dog breeds produce allergenic proteins (even poodles and "hairless" dogs).

Journal: Allergy and asthma proceedings (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't;Review
An epileptic seizure prediction model based on a time-wise attention simulation module and a pretrained ResNet.

Epilepsy is a neurological disorder that affects approximately 1% of the world's populations.Epilepsy prediction has been of great interest as it can identify and warn of an upcoming seizure, and to reduce the burden of the unpredictability of seizures.In this paper, we proposed a new seizure prediction model, tasm_res net, based on a time-wise attention simulation module and a pre-trained res net, using intracranial eeg signals.The simulation module with a time-wise attention was designed to convert eeg data into image like data and extract temporal features from raw data.Pre-trained res net was applied to reduce the amount of training data without initial training.Moreover, since the data is extremely imbalanced, we used an improved focal loss (fl) instead of the cross-entropy loss and investigated the optimal parameters for fl.Compared with a state-of-art cnn model, our proposed model achieved a better average auc of 0.877.Moreover, our results demonstrated that eeg signals can be migrated to the image network which was pre-trained on large data set through a simulation module.

Journal: Methods (San Diego, Calif.) (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Improving HPV Vaccination Rates in a Racially and Ethnically Diverse Pediatric Population.

And objectives nationally, 54.2% of youth are fully vaccinated for human papilloma virus (hpv) with persistent gender and racial/ethnic disparities.We used a quality improvement approach to improve completion of the hpv vaccine series by age 13 years.As a secondary aim, we examined racial/ethnic and gender differences in vaccine uptake.Methods the study setting included 2 pediatric, academic, primary care practices in massachusetts.We designed a multilevel patient-, provider-, and systems-level intervention addressing parental hesitancy, provider communication, and clinical operations.Rates of hpv series completion by age 13 were monitored using a control p chart.Bivariate and multivariate analyses evaluated vaccine completion differences on the basis of clinic size, gender, and race/ethnicity.Results between july 1, 2014, and september 30, 2021, control p charts showed special cause variation with hpv vaccine initiation by age 9 years, increasing from 1% to 52%, and vaccine completion by 13 years, increasing from 37% to 77%.Compared with white and black children, hispanic children were more likely to initiate the hpv vaccine at age 9 (adjusted odds ratio [95% confidence interval] = (1.4-2.6)] and complete the series by age 13 (adjusted odds ratio [95% confidence interval] = 2.3 (1.7-3.0).Conclusions a multilevel intervention was associated with sustained hpv vaccine series completion by age 13 years.Hispanic children were more likely to be vaccinated.Qualitative family input was critical to intervention design.Provider communication training addressed vaccine hesitancy.Initiation of the vaccine at age 9 and clinicwide vaccine protocols were key to sustaining improvements.

Journal: Pediatrics (2022)
Publication types: Journal Article;Research Support, N.I.H., Extramural
A novel approach for authentication of shellac resin in the shellac-based edible coatings: Contain shellac or not in the fruit wax preservative coating.

As an edible coating substrate, the detection of shellac resin has always been an intractable problem.In this paper, an authentication method of shellac resin in shellac-based edible coatings was established.Results showed that the authentication of shellac resin could be skillfully transformed as the identification of 13 targeted metabolites which were monomer compounds of shellac resin.The 13 targeted metabolites were further divided into 6 differential metabolites and 7 common metabolites with the metabonomic method and difference analysis of targeted metabolite contents.Then, four commercial soi-disant shellac-based coating solutions were selected to verify the feasibility of this method, and 7 common metabolites were detected in only one commercial sample, highly consistent with the results of shellac resin.All the above results indicated that the targeted metabolomics approach established in this study could provide a scientific basis for the qualitative authentication of shellac resin in the preservation coating.

Journal: Food chemistry: X (2022)
Publication types: Journal Article
Circular RNA triple functional domain promotes osteoarthritis' development by modulating the microRNA-136-5p/Nicotinamide phosphoribosyltransferase axis.

Numerous studies have affirmed the participation of circular rna (circ rna) in osteoarthritis (oa)' development.Previous studies have exposed the elevation of the circ rna triple functional domain (trio) in oa, while the molecular mechanism of its effect on oa remains ambiguous.During the study, it was discovered the up-regulation of circ trio in oa rats and interleukin-1β-treated chondrocytes.Knockdown circ trio facilitates chondrocyte viability, but suppresses the inflammation, the apoptosis, and matrix metalloproteinases (mmp)-3 and mmp-13 expression, whereas up-regulation aggravates oa.The effect of up-regulation or under-expression of circ trio on chondrocytes was reversed via the knockdown of nicotinamide phosphoribosyltransferase (nampt) or micro rna (mi r)-136-5p separately.Mechanically speaking, circ trio competitively adsorbing mi r-136-5p to target nampt influences oa.Briefly, the results of this study inform that the circ trio/mi r-136-5p/nampt axis is momentous in oa progression and is supposed to be a promising therapeutic target for some time.

Journal: Bioengineered (2022)
Publication types: Journal Article
The complete chloroplast genome sequence ofAthrotaxis cupressoides.

Athrotaxis cupressoides(cupressaceae) is a tasmanian endemic conifer.It is mainly threatened by habitat fragmentation and limited distribution, yet little is known about its genomic background.In this study, the complete chloroplast (cp) genome of the species was assembled and annotated.The cp genome of a.Cupressoidesis a circular of 134,248 bp in size, where the inverted repeat regions (irs) were lost.A total of 112 unique genes were annotated, including 78 proteins-coding genes, fourr rnagenes, and 30t rnagenes.The maximum likelihood (ml) phylogenetic tree indicates that the subfamily athrotaxidoideae, to which a.Cupressoidesbelongs, is sister to a clade including four subfamilies including sequoioideae, taxodioideae, cupressoideae, and callitroideae.The complete cp genome will be helpful to further studies on the conservation of this species and the evolutionary history of cupressaceae.

Journal: Mitochondrial DNA. Part B, Resources (2021)
Publication types: Journal Article
Dilemma breaking in quantum games by joint probabilities approach.

Classical games get fundamentally modified in the quantum realm because of non-locality and entanglement, that bypass some of the crucial features of the classical problem that define a dilemma.We will analyze how the dilemma can be shunted and even completely eliminated by the players using quantum strategies from the viewpoint of joint probabilities.In this approach, the game information (entropy) needs to be incorporated into the game strategies.We also connect the potential of the formalism of quantum games with the transmission of quantum information in quantum noisy channels and recent considerations of the connection between thermalization mechanisms in statistical mechanics, the many body problem and cooperative games considered here in the quantum regime.

Journal: Scientific reports (2022)
Publication types: Journal Article
Inability to Work Fulltime, Prevalence and Associated Factors Among Applicants for Work Disability Benefit.

Inability to work fulltime is an important outcome in the assessment of workers applying for a disability benefit.However, limited knowledge is available about the prevalence and degree of the inability to work fulltime, the associations between disease-related and socio-demographic factors with inability to work fulltime and whether the prevalence and the associations differ across disease groups.Methods anonymized register data on assessments of workers with residual work capacity (n = 30,177, age 48.8 ± 11.0, 53.9% female) applying for a work disability benefit in 2016 were used.Inability to work fulltime was defined as being able to work less than 8 h per day.Results the prevalence of inability to work fulltime was 39.4%, of these 62.5% could work up to 4 h per day.Higher age (or 1.01, 95% ci 1.01-1.01), female gender (or 1.45, 95% ci 1.37-1.52), higher education (or 1.44, 95% ci 1.33-1.55) and multimorbidity (or 1.06, 95% ci 1.01-1.11) showed higher odds for inability to work fulltime.Highest odds for inability to work fulltime were found for diseases of the blood, neoplasms and diseases of the respiratory system.Within specific disease groups, different associations were identified between disease-related and socio-demographic factors.Conclusion the prevalence and degree of inability to work fulltime in work disability benefit assessments is high.Specific chronic diseases are found to have higher odds for inability to work fulltime, and associated factors differ per disease group.

Journal: Journal of occupational rehabilitation (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
2-Methoxy-6-acetyl-7-methyljuglone (MAM) induced programmed necrosis in glioblastoma by targeting NAD(P)H: Quinone oxidoreductase 1 (NQO1).

Glioblastoma (gbm) are the most malignant brain tumors in humans and have a very poor prognosis.Temozolomide (tmz), the only chemotherapeutic drug for gbm treatment, induced apoptosis but frequently developed resistance.Non-apoptotic cell death offers an alternative strategy to fight cancers.Our previous studies showed that 2-methoxy-6-acetyl-7-methyljuglone (mam), a natural product, induced necroptosis in lung and colon cancer cells.The current study is designed to investigate its therapeutic potentials for gbm with in vitro and in vivo models.The protein expression of nad(p)h: quinone oxidoreductase 1 (nqo1) in human gbm specimens were detected by immunohistochemistry.Effect of mam on nqo1 was measured by recombinant protein and cellular thermal shift assay.The roles of nqo1 activation, superoxide (o2-) generation, calcium (ca2+) accumulation, and c-jun n-terminal kinase (jnk1/2) activation in mam-induced cell death in u87 and u251 glioma cells were investigated.The effect of mam on tumor growth was tested with a u251 tumor xenograft zebrafish model.Results showed that the nqo1 expression is positively correlated with the degree of malignancy in gbm tissues.Mam could directly bind and activate nqo1.Furthermore, mam treatment induced rapid o2-generation, cytosolic ca2+accumulation, and sustained jnk1/2 activation.In addition, mam significantly suppressed tumor growth in the zebrafish model.In conclusion, mam induced gbm cell death by triggering an o2-/ca2+/jnk1/2 dependent programmed necrosis.Nqo1 might be the potential target for mam and mediated its anticancer effect.This non-apoptotic necrosis might have therapeutic potentials for gbm treatment.

Journal: Free radical biology & medicine (2020)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
The Effect of Personality Traits of Surgical Nurses on COVID-19 Fear, Work Stress, and Psychological Resilience in the Pandemic.

This research was carried out to determine the effects of the personality traits of surgical nurses on covid-19 fear, work stress, and psychological resilience in the pandemic.Design the research was descriptive and cross-sectional types.Methods the study was conducted between february 2021 and may 2021 at a state university research hospital.The research aimed to reach all surgery nurses (357) working in surgical units without selecting a sample.The sample included 325 participants.At the end of the study, the participation rate was 91.03%.Study reporting adheres to strobe checklist.Findings it was determined that 43.4% of the nurses participating in the study were in the age range of 26-30, 64.9% were women.The correlation values between the covid-19 fear scale and the nurse stress scale scores were found to be significant in the positive direction.The correlation values between the eysenck personality questionnaire neuroticism subdimension and the nurse stress scale, and fear of covid-19 scale scores were found to be positive.Conclusions during the pandemic, it is suggested that nurses' work stress and psychological resilience levels should be evaluated at regular intervals and that in-service trainings on coping with stress and stress management should be organized.Taking the necessary precautions and improving working conditions will have positive effects on both the health of nurses and patient care.

Journal: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses (2023)
Publication types: Journal Article
Case Report: Successful primary percutaneous coronary intervention in octogenarian with acute-on-chronic kidney disease and total atrioventricular block after acute myocardial infarction.

Myocardial infarction (mi) is frequently complicated by the worsening of renal function.Undergoing primary percutaneous coronary intervention (pci) becomes crucial to a patient with st-segment elevation myocardial infarction (stemi).With appropriate management of mi, acute-on-chronic kidney disease (ackd) requiring dialysis post-mi remains an important clinical predictor of elevated in-hospital mortality among patients with mi.In this study, we reported an octogenarian patient suffering from stemi with ackd and total atrioventricular block (tavb).She underwent insertion of a temporary pacemaker and primary pci.Renal function was improved after dialysis by decreasing the amount of serum creatinine from 8.1 mg/d l at admission to 1.05 mg/d l after primary pci and dialysis.Primary pci should still be considered for patients with acute mi, even though these patients have kidney disease, to save the heart muscle and even indirectly improve the kidney function itself.

Journal: F1000Research (2021)
Publication types: Case Reports;Research Support, Non-U.S. Gov't;Journal Article
Modern Principles in the Acute Surgical Management of Open Distal Tibial Fractures.

Over the past two decades, management of open distal tibial fractures has evolved such that a staged approach, with external fixation and débridement during the index procedure, followed by definitive fixation and wound closure at a later date, is often considered the standard of care.Although definitive treatment of these complex injuries is often done by a multidisciplinary team of surgeons well versed in periarticular fracture repair and soft-tissue coverage in the distal extremity, the on-call orthopaedic surgeon doing the index procedure must understand the principles and rationale of the staged treatment algorithm to avoid compromising definitive treatment options and ensure the best possible patient outcome.The mechanism of injury, neurovascular status, size and location of soft-tissue injury, fracture pattern, and concomitant injuries in the polytraumatized patient should direct the treatment plan and anticipated outcomes.This review focuses on evaluation and management of these complex injuries with an emphasis on early aggressive débridement, principles of initial fracture fixation, and modern options for soft-tissue coverage, including local and free tissue transfer.

Journal: The Journal of the American Academy of Orthopaedic Surgeons (2021)
Publication types: Journal Article;Review