syedzayyan/paper_mill_benchmark huggingface dataset:
Genetic Risk, Midlife Life's Simple 7, and Incident Dementia in the Atherosclerosis Risk in Communities Study.

And objectives higher scores in life's simple 7 (ls7), a metric for cardiovascular and brain health, have been associated with lower risk of dementia.It is uncertain whether this association holds among those with high genetic risk of dementia.Our objective is to evaluate the extent that ls7 may offset dementia risk across the range of genetic risk.Methods participants in the atherosclerosis risk in communities (aric) study were followed from 1987-1989 to 2019.We derived midlife ls7 scores and generated genetic risk scores (grs) using genome-wide summary statistics of alzheimer disease, which have been used to study the genetic risk for dementia.Incident dementia was ascertained based on the criteria of the national institute on aging-alzheimer's association workgroups and diagnostic and statistical manual of mental disorders.The associations of the grs and ls7 with incident dementia were evaluated using cox regression.Results this study included 8,823 european american (ea) and 2,738 african american (aa) participants (mean age at baseline 54 years).We observed 1,603 cases of dementia among ea participants and 631 among aa participants (median follow-up 26.2 years).Higher grs were associated with higher risk of dementia (ea, hazard ratio [hr] per sd 1.44, 95% ci 1.37, 1.51; aa, hr 1.26, 95% ci 1.16, 1.36).Among ea participants, higher ls7 scores were consistently associated with lower risk of dementia across quintiles of grs, including the highest quintile (hr per point 0.91, 95% ci 0.87, 0.96).Among aa participants, the associations between ls7 and incident dementia within stratum of grs had the same direction as among ea participants, although wide cis and smaller sample sizes limited reliable inferences.Discussion across strata of grs, higher midlife ls7 scores were associated with lower risk of dementia.Larger sample sizes from diverse populations are needed to obtain more reliable estimates of the effects of modifiable health factors on dementia risk within genetic risk strata in each ancestry group.

Journal: Neurology (2022)
Publication types: Journal Article
The change from UMAT to UCAT for undergraduate medical school applicants: impact on selection outcomes.

S to assess whether the change from the undergraduate medical and health sciences admissions test (umat; 1991-2019) to the university clinical aptitude test (ucat) for the 2020 new south wales undergraduate medical degree intake was associated with changes in the impact of sex, socio-economic status and remoteness of residence, and professional coaching upon selection for interview.Design, setting, participants cross-sectional study of applicants for the three nsw undergraduate medical programs for entry in 2019 (4114 applicants) or 2020 (4270); 703 people applied for both intakes.Applicants selected for interview were surveyed about whether they had received professional coaching for the selection test.Main outcome measures scores on the three sections of the umat (2019 entry cohort) and the five subtests of the ucat (2020 entry); total umat and ucat scores.Results mean scores for umat 1 and 3 and for all four ucat cognitive subtests were higher for men than women; the differences were statistically significant after adjusting for age, socio-economic status, and remoteness.The effect size for sex was 0.24 (95% ci, 0.18-0.30) for umat total score, 0.38 (95% ci, 0.32-0.44) for ucat total score.For the 2020 intake, 2303 of 4270 applicants (53.9%) and 476 of 1074 interviewees (44.3%) were women.The effect size for socio-economic status was 0.47 (95% ci, 0.39-0.54) for umat, 0.43 (95% ci, 0.35-0.50) for ucat total score; the effect size for remoteness was 0.54 (95% ci, 0.45-0.63) for umat, 0.48 (95% ci, 0.39-0.58) for ucat total score.The impact of professional coaching on ucat performance was not statistically significant among those accepted for interview.Conclusions women and people from areas outside major cities or of lower socio-economic status perform less well on the ucat than other applicants.Reviewing the test and applicant quotas may be needed to achieve selection equity.

Journal: The Medical journal of Australia (2021)
Publication types: Journal Article
Prognostic nomogram that predicts progression-free survival and overall survival of patients with ovarian clear cell carcinoma.

S we aims to develop nomograms to predict progression-free survival (pfs) and overall survival (os) in patients with ovarian clear cell carcinoma (occc) after primary treatment and compare the predictive accuracy with the currently used international federation of gynecology and obstetrics (figo) system.Methods we collected data from 358 chinese patients diagnosed with occc and who underwent standard treatment at our hospital.Patients diagnosed from 1982-9 to 2011-12 were classified as the training group and patients diagnosed from 2012-1 to 2016-11 were classified as the validation group.Nomograms were developed based on the training group and was validated in the validation group.The predictive performance was determined by concordance index and calibration curve.Results the most predictive nomogram for pfs was constructed using variables: thrombosis, the figo staging, residual of the tumor and distant metastasis, with a concordance index of 0.738.While the nomogram for os consisted of thrombosis, lymph node metastasis, residual of the tumor, malignant ascites/washing, and platinum resistance, with a concordance index of 0.835.The nomograms were internally validated by concordance indexes of 0.775 and 0.807 for predicting pfs and os, respectively.In comparison, the concordance statistics for os based on the figo staging was significantly lower (p<0.05).Conclusion we have established two prognostic nomograms for recurrence and long-term survival in patients with occc after primary treatment in a large chinese center and validated them in patients from the same center.This tool used variables specifically related to occc and was more accurate than the figo system.It is relatively easy to use in clinic for patient counseling, postoperative management, and follow-up for individual patients.

Journal: Frontiers in oncology (2022)
Publication types: Journal Article
LncRNA DANCR improves the dysfunction of the intestinal barrier and alleviates epithelial injury by targeting the miR-1306-5p/PLK1 axis in sepsis.

Intestinal barrier dysfunction often occurs in various acute or chronic pathological conditions and has been identified as an important clinical problem.Herein, we explored the biological role and molecular mechanism of polo-like kinase 1 (plk1) and differentiation antagonizing non-protein coding rna (dancr) in intestinal barrier dysfunction caused by sepsis.Rt-q pcr analysis was used to examine plk1, mi r-1306-5p, and dancr expression in ncm460 cells after lps treatment.Tunel assay and western blot analysis were performed to explore plk1 function in cell apoptosis and intestinal barrier in vitro.Hematoxylin and eosin staining, western blot analysis, and tunel assay were used to investigate dancr function in the intestinal barrier and cell apoptosis in vivo.The interaction between mi r-1306-5p and plk1 (or dancr) was validated by luciferase reporter assay.As a result, plk1 overexpression decreased cell apoptosis and promoted intestinal barrier function.Moreover, dancr was validated as a sponge of mi r-1306-5p to target plk1.In addition, we found that dancr overexpression decreased intestinal mucosal permeability and colon mucosa epithelial cell apoptosis in vivo.Conclusively, dancr improved intestinal barrier dysfunction and alleviated epithelial injury by targeting the mi r-1306-5p/plk1 axis in sepsis.

Journal: Cell biology international (2021)
Publication types: Journal Article
Biocontrol fungi induced stem-base rot disease resistance ofMorinda officinalisHow revealed by transcriptome analysis.

Introduction morinda officinalis how (mo) is a rubiaceae plant, and its medicinal part is dried root, which is one of the "four southern medicines" in china.At present, the plant mo breed seedlings mainly by cutting methods.Long-term asexual propagation makes pathogenic fungi accumulate in mo, leading to stem-base rot, which is caused by fusarium oxysporum(fon).Methods in this study, we used trichoderma harzianumand pestalotiopsissp.As biocontrol fungi to investigate their antagonistic ability to fon through in vitro antagonism and pot experiments, and combined with transcriptome sequencing to explore the mechanism of biocontrol.Results the results showed that both trichoderma harzianumand pestalotiopsissp.Could inhibit the growth of fon.In addition,trichoderma harzianumand pestalotiopsissp.Could also enhance the basic immunity to fon by increasing the activities of defensive enzymes such as pod and sod, chlorophyll content, soluble sugar content, and oligosaccharide content of mo.The mechanism of biological control of stem-base rot of mo was discussed by transcriptome technology.Mo was treated with two treatments, root irrigation with biocontrol fungi or inoculation with fon after root irrigation with biocontrol fungi.Transcriptome sequencing revealed that nearly 11,188 differentially expressed genes (degs) were involved in the process of inducing mo systemic resistance to fon by biocontrol fungi.Meanwhile, gene ontology (go) classification and kyoto encyclopedia of genes and genomes (kegg) pathway enrichment, as well as transcription factor (tfs) prediction showed that there were significant differences in the expression levels of mo roots under different treatments.Also, the genes of the "mapk signaling pathway" and "plant hormone signaling pathway" were analyzed, in which the erfs gene of the ethylene signal transduction pathway participated in the metabolism of glycosyl compounds.It is speculated that the ethylene signal may participate in the immune response of the sugar signal to the infection of fon.After q rt-pcr verification of 10 degs related to the ethylene signal transduction pathway, the expression trend is consistent with the results of transcriptome sequencing, which proves the reliability of transcriptome sequencing.Discussion in conclusion, this study preliminarily identified the molecular mechanism of the biological control of mo stem-base rot and provided a scientific basis for further research on the prevention and control mechanism of mo stem-base rot.

Journal: Frontiers in microbiology (2023)
Publication types: Journal Article
Factors Affecting Medical Students' Continuance Intention to Use Mobile Health Applications.

With the dramatic growth in smartphones, mobile health applications (apps) in the field of healthcare or medicine, which are characterized by strong operability, flexibility and interactivity, provide a supplementary approach to medical learning.The aims of this study were to awaken medical students to pay more attention to the learning function of mobile health app and gain deeper insight into our understanding of the factors influencing medical students' mobile health apps continuance intention for enhancing practical utilization.Methods a cross-sectional survey was conducted with a self-designed questionnaire administered to medical students at chongqing medical university.Data were collected from 450 participants from march to april 2019.Spss v.25 was used for the descriptive statistical analysis of the results.Smart pls 3.2.7 was used to construct a structural equation modelling framework to estimate the influencing factors of medical students' continuance intention to use mobile health apps.Results the external characteristics of mobile health apps had a positive influence on perceived ease of use (β = 0.378,p< 0.001).Perceived ease of use had a positive impact on perceived usefulness (β = 0.573,p< 0.001).Perceived ease of use (β = 0.195,p= 0.011), perceived usefulness (β = 0.450,p< 0.001) and subjective norms (β = 0.255,p< 0.001) had a positive impact on attitude towards using mobile health apps.Additionally, perceived usefulness (β = 0.202,p< 0.001) and attitude (β = 0.730,p< 0.001) had a remarkable influence on continuance intention.Furthermore, the mediating effect of attitude between perceived usefulness and continuance intention was significant (β = 0.329,p< 0.001).Conclusion both perceived usefulness and attitude have a significant effect on medical students' mobile health apps continuance intention.So, we suggest apps providers and developers evoking and maintaining users' interest in mobile health apps and perfecting apps' features from various aspect.Also, more attention should be paid on social relationship to introduce medical students to familiarize mobile health apps and strengthen adhesiveness of medical students.

Journal: Journal of multidisciplinary healthcare (2022)
Publication types: Journal Article
An Extremely Rare Congenital Muscle Bundle Crossing the Right Atrial Cavity.

Muscle bundles in the right atrium are an extremely rare congenital anomaly.We report the case of a patient with 2 atrial septal defects and a large muscle bundle crossing the right atrium.Only 3 comparable cases have previously been published.(level of difficulty: intermediate.).

Journal: JACC. Case reports (2022)
Publication types: Case Reports;Journal Article
Continuous inter-limb coordination deficits in children with unilateral spastic cerebral palsy.

Continuous inter-limb coordination and the ability to offset perturbations to a movement pattern (i.e., stability) are important factors in efficient motor performance.Patients with movement disorders often show deficits in coordination and stability, although little is known about these features in children with cerebral palsy.The purpose of this study was to identify the continuous inter-limb coordination and stability deficits in children with cerebral palsy and determine if improvement occurs with upper extremity intervention.Methods children with cerebral palsy participated in bimanual or unimanual intensive therapy.Continuous inter-limb coordination between the arms and between the more-affected arm and leg was evaluated using relative phase analysis during four gross motor tasks, including in-place marching and standing with asymmetric and symmetric arm swing.A control group of children with cerebral palsy and a group of typically developing children were also evaluated.Findings children with cerebral palsy displayed coordination deficits compared to typically developing children (p 0.05 for all cases).Interpretation relative phase analysis successfully provided a sensitive measurement of coordination and stability in pathologic and non-pathologic populations.Findings indicate that all children have difficulty producing consistent movement patterns and suggest that both bimanual and unimanual interventions can improve continuous coordination in children with cerebral palsy.

Journal: Clinical biomechanics (Bristol, Avon) (2021)
Publication types: Journal Article
Late Onset Uveitis-glaucoma-hyphema Syndrome with Out-the-bag Placement of Intraocular Lens.

To report a case of uveitis-glaucoma-hyphema (ugh) syndrome secondary to a tilted toric intraocular lens (iol).Background over the past few decades, upgrades in lens design, surgical techniques, and posterior chamber iols have drastically decreased the incidence of ugh syndrome.We present a rare case of ugh syndrome developing 2 years after a seemingly uneventful cataract surgery and its subsequent management.Case description a 69-year-old female presented with episodes of sudden visual disturbance in her right eye 2 years after a seemingly uneventful cataract surgery with placement of a toric iol.Workup included ultrasound biomicroscopy (ubm), which revealed a tilted iol and confirmed haptic-induced iris transillumination defects consistent with the diagnosis of ugh syndrome.The patient underwent surgical repositioning of the iol, which led to the resolution of ugh.Conclusion uuveitis-glaucoma-hyphema developed from a tilted toric iol inducing posterior iris chaffing.Careful examination and ubm revealed the iol and haptic out of the bag position, which was critical in determining the underlying ugh mechanism.The surgical intervention led to the resolution of ugh syndrome.Clinical significance in patients with a history of uneventful cataract surgery who develop ugh-like symptoms, continued examination of implant orientation and haptic position is critical in preventing the need for future procedures.How to cite this article zhou b, bekerman vp, chu ds,et al.late onset uveitis-glaucoma-hyphema syndrome with out-the-bag placement of intraocular lens.J curr glaucoma pract 2022;16(3):205-207.

Journal: Journal of current glaucoma practice (2022)
Publication types: Case Reports;Journal Article
Renal biomarkers in cats: A review of the current status in chronic kidney disease.

Serum creatinine concentration, the classical biomarker of chronic kidney disease (ckd) in cats, has important limitations that decrease its value as a biomarker of early ckd.Recently, serum symmetric dimethylarginine concentration was introduced as a novel glomerular filtration rate biomarker for the early detection of ckd in cats.However, data on its specificity are still limited.The limitations of conventional biomarkers and the desire for early therapeutic intervention in cats with ckd to improve outcomes have prompted the discovery and validation of novel renal biomarkers to detect glomerular or tubular dysfunction.Changes in the serum or urinary concentrations of these biomarkers may indicate early kidney damage or predict the progression of kidney before changes in conventional biomarkers are detectable.This review summarizes current knowledge on renal biomarkers in ckd in cats, a field that has progressed substantially over the last 5 years.

Journal: Journal of veterinary internal medicine (2022)
Publication types: Journal Article;Review
Benchmarking Treatment Adherence and Therapist Competence in Individual Cognitive-Behavioral Treatment for Youth Anxiety Disorders.

Evidence-based treatments (ebts) for youth are typically developed and established through studies in research settings designed to ensure treatment integrity, that is, protocol adherence and competence by therapists.An important question for implementation science is how well integrity is maintained when these ebts are delivered in community settings.The present study investigated whether the integrity achieved by therapists in community settings achieved a benchmark set by therapists in a research setting when they delivered the same ebt-an individual cognitive-behavioral treatment (icbt) for youth anxiety.Therapists (n = 29; 68.97% white; 13.79% male) provided icbt to 68 youths (m age = 10.60 years, sd = 2.03; 82.35% white; 52.94% male) diagnosed with a principal anxiety disorder in research or community settings.Training and supervision protocols were the same across settings.Two independent teams of trained coders rated 744 sessions using observational instruments designed to assess icbt adherence and competence.Both adherence and competence were higher in the research setting.Group differences in competence were consistent across treatment, but differences in adherence were most pronounced when treatment shifted to exposure, widely viewed as the most critical component of icbt.When using the benchmarks from the research setting, therapists from the community settings fell short for indices of adherence and competence.However, given differences between therapists and clients, as well as the fact that treatment outcomes were similar across settings, our findings raise questions about whether it is appropriate to use treatment integrity benchmarks from research settings for community.

Journal: Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 (2019)
Publication types: Journal Article;Research Support, N.I.H., Extramural
The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters, Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models.

Human organic anion/cation transporters (oats/octs), organic anion transporting polypeptides (oatps) and proton-coupled oligopeptide transporters (pep ts) are important membrane transporters responsible of the cellular influx of drugs in many human key tissues.Inhibitor(s) impacting on the cellular uptake of transporter drug substrates is one of the primary causes of drug-drug interactions that lead to unsatisfied therapeutic outcomes and/or unwanted side effects.In the current study, we selected eighteen antibiotic agents used in infectious disease treatment and comprehensively evaluated their inhibitory effects on the substrate uptake mediated through the essential oats/octs, oatps and pep ts isoforms.Transport functional assay, dose-response curve and kinetic analysis were performed on the hek293 cells over-expressing each of these transporter genes.Our data revealed that nitrofurantoin, sulfadiazine and metronidazole significantly inhibited the transport activity of oat3 (ic50values of 6.23±1.33μm, 6.65±1.30μm and 6.51±0.99μm; kivalues of 5.86μm, 3.98μm and 6.48μm, respectively).Trimethoprim and ciprofloxacin potently decreased the substrate uptake mediated via oatp1a2 (ic50values of 9.35±1.10μm and 9.25±1.18μm; kivalues of 8.19μm and 7.64μm, respectively).In addition, these antibiotic agents consistently decreased methotrexate influx via oat3 and oatp1a2.In summary, our study is the first to show that nitrofurantoin, sulfadiazine and metronidazole are potent inhibitors of oat3 and trimethoprim is a novel inhibitor of oatp1a2.Our study also provides new evidence for the drug-drug interactions of ciprofloxacin with oatp1a2 drug substrates like methotrexate.Therefore, precautions are required when co-administering these antibiotics with oat3 or oatp1a2 drug substrates.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2018)
Publication types: Journal Article
Bending oxygen saturation index and risk of worsening heart failure events in chronic heart failure.

S bendopnea is a clinical symptom of advanced heart failure with uncertain prognostic value.We aimed to evaluate whether bendopnea and the change in oxygen saturation when bending forward (bending oxygen saturation index [bosi]) are associated with adverse outcomes in ambulatory chronic heart failure (chf) patients.Methods and results we prospectively evaluated 440 subjects with symptomatic chf.Bosi was defined as the difference between sitting and bending oxygen saturation (sp o2).The endpoint was the total number of worsening heart failure (whf) events (heart failure hospitalization or urgent heart failure visit requiring parenteral diuretic therapy).The mean age was 74 ± 10 years, 257 (58.6%) were male, and 226 (51.4%) had a left ventricular ejection fraction <50%.Bendopnea was present in 94 (21.4%) patients, and 120 (27.3%) patients had a bosi ≥-3%.The agreement between bosi ≥-3% and bendopnea was moderate (gwet's ac 0.482, p < 0.001).At a median (p25%-p75%) follow-up of 2.17 years (0.88-3.16), we registered 441 whf events in 148 patients.After multivariable adjustment, bosi was independently associated with the risk for total whf episodes (overall, p < 0.001).Compared to improvement/no change in sp o2when bending (bosi 0%), those with bosi ≥-3% showed an increased risk of whf events (incidence rate ratio [irr] 2.16, 95% confidence interval [ci] 1.67-2.79; p < 0.001).In contrast, bendopnea was not associated with the risk of total whf episodes (irr 1.04, 95% ci 0.83-1.31; p = 0.705).Conclusions in ambulatory and stable chf patients, bosi ≥-3% and not bendopnea was independently associated with an increased risk of total (first and recurrent) whf episodes.Awareness of sp o2while assessing bendopnea may be a useful tool for predicting heart failure decompensations.

Journal: European journal of heart failure (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't