syedzayyan/paper_mill_benchmark huggingface dataset:
Preoperative prediction of the pathological stage of advanced gastric cancer by18F-fluoro-2-deoxyglucose positron emission tomography.

In recent years, the usefulness of neoadjuvant chemotherapy for resectable advanced gastric cancer, particularly stage iii, has been reported.Preoperative staging is mainly determined by computed tomography (ct), and the usefulness of18f-fluoro-2-deoxyglucose positron emission tomography/ct (fdg-pet/ct) for gastric cancer has been limited in usefulness.The study aimed to evaluate the usefulness of fdg-pet/ct in preoperative diagnosis of advanced gastric cancer.We retrospectively enrolled 113 patients with gastric cancer who underwent preoperative fdg-pet/ct.All patients underwent gastrectomy with lymph-node dissection.The maximum standardized uptake value (suvmax) of the primary tumor (t-suvmax) and lymph nodes (n-suvmax) were measured for all patients.The cutoff values of t-suvmax for pathological t3/4 from receiver operating characteristic analysis were 8.28 for differentiated and 4.32 for undifferentiated types.The t-suvmax and n-suvmax cutoff values for pathological lymph-node metastasis were 4.32 and 1.82, respectively.Multivariate analysis showed that t-suvmax for differentiated types was a significant predictor of pathological t3/4, and n-suvmax was a significant predictor of lymph-node metastasis.In conclusion, the suvmax of fdg-pet/ct was a useful predictor of pathological t3/4 and lymph-node metastasis in gastric cancer.The diagnosis by preoperative fdg-pet/ct is promising to contribute a more accurate staging of gastric cancer than by ct scan alone.

Journal: Scientific reports (2022)
Publication types: Journal Article
Naringenin Improves Ovalbumin-Induced Allergic Asthma in Rats through Antioxidant and Anti-Inflammatory Effects.

Asthma is a chronic disease with eosinophilic inflammation and oxidative damages leading to airway obstruction.Naringenin is a phytochemical possessing strong antioxidant and anti-inflammatory activities against chronic destructive conditions.The current study is devoted to evaluating naringenin's effects on the attenuation of inflammation and oxidative stress in lung tissue in a rat model of ovalbumin-induced asthma.Male wistar rats were allocated to five groups of six: normal control (nc, receiving 1 ml/day of normal saline, orally), asthmatic (as, receiving ovalbumin (1 mg/m l), and alum (1 mg/m l in saline) on days 0 and 14.Then, on days 21, 22, and 23, they were sensitized with the inhalation of ovalbumin), as treated with dexamethasone (as, 1 mg/kg/day, orally) [as + d1], as treated with naringenin (20 mg/kg/day, orally) [as + n20], and as treated with naringenin (40 mg/kg/day, orally) [as + n40].All the groups received associated drugs/agents for 28 days.Finally, bronchoalveolar lavage fluid (balf) and lung tissue samples were taken off from the animals.The eosinophil count in balf and malondialdehyde (mda), glutathione (gsh), interleukin-13 and -4 (il-13 and il-4) levels were measured.Besides, the expression of urocortin (ucn) and surfactant protein-d (sp-d) were evaluated in the lung tissue using immunohistochemistry (ihc) and western blotting methods, respectively.Hematoxylin and eosin (h&e) staining were utilized to conduct histopathological analysis.Naringenin treatment significantly reduced mda, remarkably increased gsh, and meaningfully reduced il-4 and il-13 levels in lung tissue.The count of eosinophils in the balf of as + n20 and as + n40 was significantly reduced in comparison with the as group.The ucn and sp-d protein levels were significantly decreased in the as + n20 and as + n40 groups compared to the as group, using the ihc and western blot methods, respectively.Histopathological analysis data also confirm the results.Naringenin improves the symptoms of allergic asthma through antioxidant and anti-inflammatory effects.

Journal: Evidence-based complementary and alternative medicine : eCAM (2022)
Publication types: Journal Article
Implementing online patient feedback in a 'special measures' acute hospital: A case study using Normalisation Process Theory.

Online patient feedback is becoming increasingly prevalent on an international scale.However, limited research has explored how healthcare organisations implement such feedback.This research sought to explore how an acute hospital, recently placed into 'special measures' by a regulatory body implemented online feedback to support its improvement journey.Methods semi-structured interviews were conducted with eleven key stakeholders involved in the implementation and/or use of online patient feedback.Data was analysed using deductive thematic analysis with normalisation process theory used as the analytical framework.Research findings are translated into the engage, support and promote (esp) model, a model of rapid feedback adoption.Results participants viewed the implementation of online feedback as an opportunity to learn, change and improve.Factors found to facilitate implementation were often linked to engagement, support and promotion.Although less frequently described, barriers to implementation included staff anxieties about time pressures, moderation processes and responding responsibilities.Such anxieties were often addressed by activities including the provision of evidence based responder training.Overall, staff were overwhelmingly positive about the value of online feedback with 24 impacts identified at an individual and organisational level, including the ability to boost staff morale, resilience and pride.Conclusions the rapid implementation of online patient feedback can be achieved in a 'special measures' organisation.However, the difficulties of implementing such feedback should not be underestimated.In order to embed online feedback, staff members need to be engaged and feel supported, with opportunities to provide, respond and invite patient feedback frequently promoted to both patients and staff members.

Journal: Digital health (2021)
Publication types: Case Reports;Journal Article
Difficult Times, Difficult Decisions: Examining the Impact of Perceived Crisis Response Strategies During COVID-19.

Crises, such as the covid-19 pandemic, require rapid action to be taken by leaders, despite minimal understanding of the impact of implemented crisis management policies and procedures in organizations.This study's purpose was to establish a greater understanding of which perceived crisis response strategies were the most beneficial or detrimental to relevant perceptions and outcomes during the recent covid-19 crisis.Using a time-lagged study design and a sample of 454 healthcare employees, latent profile analysis was used to identify strategy profiles used by organizations based on several policy/procedure categories (i.e., human-resource supportive, human-resource disadvantaging, behavioral/interactional human safety and protection-focused, and environmental and structural safety supports-focused policies and procedures).Results indicated that four perceived crisis response strategies were employed: (1) human resource-disadvantaging, (2) maximizing, (3) safety and human resource-supportive, and (4) inactive.Perceived crisis response strategy was linked to several employee well-being (e.g., work stress) and behavioral (e.g., safety behavior) outcomes via proximal perceptions (i.e., perceived organizational support, ethical leadership, and safety climate).Proximal perceptions were the most positive for employees within organizations that enacted safety and human resource-supportive policies and procedures or that utilized a maximizing approach by implementing a wide array of crisis response policies and procedures.This paper contributes to the literature by providing crucial information needed to reduce organizational decision-making time in the event of future crises.

Journal: Journal of business and psychology (2022)
Publication types: Journal Article
Multiterritorial strokes in the setting of spontaneous heparin-induced thrombocytopaenia syndrome.

We present a case study of a 38-year-old man who developed arterial and venous thrombi, resulting in multiterritorial strokes, a pulmonary embolus and a cerebral venous sinus thrombosis in the setting of spontaneous heparin-induced thrombocytopaenia syndrome.

Journal: BMJ case reports (2022)
Publication types: Case Reports;Journal Article
Production and Purification of Shark and Camel Single-Domain Antibodies from Bacterial and Mammalian Cell Expression Systems.

Single-domain antibodies, including the antigen-binding variable domains of the shark immunoglobulin new antigen receptor and the camelid variable region of the heavy chain, are the smallest antigen recognition domains (∼15 k da) and have unique characteristics compared to conventional antibodies.They are capable of binding epitopes that are hard to access for classical antibodies and can also be used for therapeutics or diagnostics or as modular building blocks for multi-domain constructs, antibody-drug conjugates, immunotoxins, or chimeric antigen receptor therapy.This article contains detailed procedures for the purification and validation of two single-domain antibodies (one shark and one camel), which bind to the s2 subunit of the sars-co v-2 spike protein, using both bacterial and mammalian cell expression systems.It provides a comprehensive reference for the production of single-domain antibodies with high yield, good quality, and purity.© published 2022.This article is a u.s.Government work and is in the public domain in the usa.Basic protocol: production of single-domain antibodies from escherichia coli alternate protocol: production of single-domain antibodies using the mammalian cell line expi293f support protocol 1: production and purification of single-domain antibodies on a small scale with the polymyxin b method support protocol 2: validation of single-domain antibodies by elisa.

Journal: Current protocols (2022)
Publication types: Journal Article
Effect of Apatinib plus melatonin on vasculogenic mimicry formation by cancer stem cells from breast cancer cell line.

And aim vasculogenic mimicry (vm) is one of the most important causes of breast cancer metastasis and resistance against drugs.The cancer stem cells (cscs) are known as essential factors for vm formation.In this study, the effects of melatonin, apatinib, and a combination of apatinib/melatonin on vm formation were investigated by breast cscs from breast cancer cell line.Materials and methods the percentage of cscs was determined in two breast cancer cell lines (mcf-7 and mda-mb-231) by flow cytometry.The effects of apatinib, melatonin, and a combination of apatinib/melatonin were evaluated on proliferation and viability, migration and invasion, apoptosis, and vm formation in mda-mb-231 cells.Moreover, expression levels of the involved proteins in cancer cell proliferation and viability, cscs, migration and invasion, and vm formation were evaluated by real-time polymerase chain reaction (rt-pcr) and western blotting methods.Results results of the present study showed that melatonin and apatinib reduced survival rate of cscs in a dose- and time-dependent manner.Apatinib, melatonin, and a combination of apatinib/melatonin inhibited proliferation of breast cscs (p ≤ 0.001).Formation of vm was decreased in the mda-mb-231 cancer cell line treated with apatinib and combination of apatinib/melatonin.Apatinib and combination of apatinib/melatonin reduced invasion of breast cscs (p ≤ 0.0001).Expression of vascular endothelial ve-cadherin, ephrin a2 receptor (epha2), p-pi3k/phosphoinositide-3 kinase (pi3k) and phospho-akt (p-akt)/akt ratios was decreased under the influence of apatinib and a combination of apatinib/melatonin (p ≤ 0.01).Conclusion apatinib or a combination of apatinib/melatonin may be used to manage patients with breast cancer.However, further studies are needed to identify anti-cancer mechanisms of melatonin and apatinib for better management of the patients with breast cancer.

Journal: Breast cancer (Tokyo, Japan) (2022)
Publication types: Journal Article
Surgical Considerations in Endoscopic Pituitary Dissection for the Neurosurgeon.

Many surgical considerations exist for an endoscopic approach for pituitary surgery for a neurosurgeon.The neurosurgical approach to endoscopic pituitary dissection requires proper surgical planning and identification of relevant anatomic structures.With the introduction of endoscopic transsphenoidal pituitary surgery, better visualization and more intricate surgical resections are achieved.Whether performing this surgery solo or with an otolaryngologist, the neurosurgeon must consider multiple aspects for this surgical approach.This article focuses on the surgical considerations involving the anatomic regions of the sphenoid sinus and sellar region for endoscopic pituitary dissections.

Journal: Otolaryngologic clinics of North America (2022)
Publication types: Journal Article;Review
Canine Endotheliochorial Placenta: Morpho-Functional Aspects.

In the domestic dog, placentation arises from central implantation, passing through a transitional, yet important stage of choriovitelline placenta (yolk sac placenta), on the way to the formation of the definite, deciduate, zonary (girdle) allantochorionic endotheliochorial placenta.sharing some similarities with other invasive types of placentation, e.g., by revealing decidualization, it is characterized by restricted (shallow) invasion of trophoblast not affecting maternal capillaries and maternal decidual cells.Thus, being structurally and functionally placed between noninvasive epitheliochorial placentation and the more invasive hemochorial type, it presents an interesting and important model for understanding the evolutionarily determined aspects of mammalian placentation.More profound insights into the biological mechanisms underlying the restricted invasion of the fetal trophoblast into maternal uterine structures and the role of decidual cells in that process could provide better understanding of some adverse conditions occurring in humans, like preeclampsia or placenta accreta.As an important endocrine organ actively responding to ovarian steroids and producing its own hormones, e.g., serving as the source of gestational relaxin or prepartum prostaglandins, the canine placenta has become an attractive research target, both in basic and clinical research.In particular, the placental feto-maternal communication between maternal stroma-derived decidual cells and fetal trophoblast cells (i.e., an interplay between placenta materna and placenta fetalis) during the maintenance and termination of canine pregnancy serves as an interesting model for induction of parturition in mammals and is an attractive subject for translational and comparative research.Here, an updated view on morpho-functional aspects associated with canine placentation is presented.

Journal: Advances in anatomy, embryology, and cell biology (2021)
Publication types: Journal Article
Effects of the Licorice Isoflavans Licoricidin and Glabridin on the Growth, Adherence Properties, and Acid Production ofStreptococcus mutans, and Assessment of Their Biocompatibility.

Pharmacological studies have linked a number of human health benefits with licorice due to its anticancer, anti-inflammatory, anti-oxidant, and antimicrobial properties.The aim of this study was to investigate the effects of licoricidin and glabridin, two major licorice isoflavans, on growth and virulence properties (biofilm formation, acid production, dextran production, adherence) of the cariogenic bacterium streptococcus mutans.Moreover, the biocompatibility of these licorice compounds was assessed in an in vitro model of oral keratinocytes.We used a broth microdilution assay to show that licoricidin and glabridin exhibit a marked antibacterial activity against s.Mutans.Glabridin and, to a lesser extent, licoricidin reduced the biofilm viability of s.Mutans.In addition, glabridin decreased the production of dextran by s.Mutans.The two licorice isoflavans attenuated the adherence of s.Mutansto a saliva-coated hydroxylapatite surface, and reduced acid production from glucose.Lastly, depending on the concentrations tested, the two licorice isoflavans showed no or low toxicity toward oral keratinocytes.Within the limitations of this study, our data suggest that licoricidin and glabridin may be promising agents for controlling dental caries.

Journal: Antibiotics (Basel, Switzerland) (2021)
Publication types: Journal Article
Factors Influencing Compassion Fatigue among Hospice and Palliative Care Unit Nurses.

This descriptive study aimed to explore nursing workplace spirituality, end-of-life care stress, and resilience as factors influencing compassion fatigue among nurses working in hospice and palliative care units.Methods data were collected using a self-report questionnaire completed by 146 nurses at 14 hospice and palliative care institutions across south korea who had worked in a hospice and palliative care institution for at least 6 months and had experience providing end-of-life care.Data were collected from february 25, 2019 to april 12, 2019, and analyzed using spss for windows version 18.0.As appropriate, descriptive statistics, the t-test, analysis of variance, the scheffé test, pearson correlation coefficients, and stepwise multiple regression were used.Results the survey results showed that factors influencing compassion fatigue were resilience, subjective health status, current satisfaction with the hospice ward, and end-of-life care stress.Higher levels of resilience, a subjective health status of "healthy", high levels of current satisfaction with the hospice ward, and lower levels of end-of-life care stress were associated with lower levels of compassion fatigue, explaining 42.9% of the total variance.Conclusion the results of this study suggest that resilience is an important factor mitigating compassion fatigue among nurses at hospice and palliative care institutions.Therefore, intervention programs should be developed to reduce compassion fatigue.

Journal: Journal of hospice and palliative care (2021)
Publication types: Journal Article
Current status and future perspectives on immunotherapy in neoadjuvant therapy of resectable non-small cell lung cancer.

Resectable non-small cell lung cancer (nsclc) is defined as stage i-ii, and some locally advanced (stage iii) tumor.Despite the associated relatively high recurrence rates after surgery, surgical treatment remains the standard treatment for patients with early-stage nsclc.At present, neoadjuvant therapy is becoming an increasingly popular therapeutic strategy for resectable nsclc.However, studies have reported that neoadjuvant chemotherapy only slightly improves recurrence rates, making it inadequate for extending patient survival.The significant survival benefits of immunotherapy in advanced nsclc have greatly stimulated researchers' interests in applying immune checkpoint inhibitors (icis) for treating early-stage resectable nsclc.A few recent phase ii radomized clinical trials suggested that icis yield better major pathologic response (mpr) rates than neoadjuvant chemotherapy alone, demonstrating their potential as alternatives to the existing fixed therapy pattern for early-stage nsclc.Most initial studies regarding neoadjuvant immunotherapy selected mpr and pathologic complete response (p cr) as primary or secondary endpoints, leading to a significant reduction in the time and cost of research and development compared with the use of overall survival time and median survival time as endpoints.Meanwhile, to confirm these benefits, more phase iii clinical trials are being conducted, and there is a growing demand for research on related problems, including the screening of population, formulation of treatment strategies, duration and course of immunotherapy, influence of neoadjuvant immunotherapy on the safety of surgery, standardization of treatment effect evaluation and pathologic evaluation, and ways to effectively identify pseudoprogression and avoid resultant misjudgment in surgery and adjuvant therapy.

Journal: Asia-Pacific journal of clinical oncology (2022)
Publication types: Journal Article;Review
Effect of Set-Structure on Upper-Body Muscular Hypertrophy and Performance in Recreationally-Trained Male and Female.

Davies, tb, halaki, m, orr, r, mitchell, l, helms, er, clarke, j, and hackett, da.Effect of set structure on upper-body muscular hypertrophy and performance in recreationally trained men and women.J strength cond res 36(8): 2176-2185, 2022-this study explored the effect of volume-equated traditional-set and cluster-set structures on muscular hypertrophy and performance after high-load resistance training manipulating the bench press exercise.Twenty-one recreationally trained subjects (12 men and 9 women) performed a 3-week familiarization phase and were then randomized into one of two 8-week upper-body and lower-body split programs occurring over 3 and then progressing to 4 sessions per week.Subjects performed 4 sets of 5 repetitions at 85% one repetition maximum (1rm) using a traditional-set structure (trad, n = 10), which involved 5 minutes of interset rest only, or a cluster-set structure, which included 30-second inter-repetition rest and 3 minutes of interset rest (clus, n = 11).A 1rm bench press, repetitions to failure at 70% 1rm, regional muscle thickness, and dual-energy x-ray absorptiometry were used to estimate changes in muscular strength, local muscular endurance, regional muscular hypertrophy, and body composition, respectively.Velocity loss was assessed using a linear position transducer at the intervention midpoint.Trad demonstrated a significantly greater velocity loss magnitude (g = 1.50) and muscle thickness of the proximal pectoralis major (g = -0.34) compared with clus.There were no significant differences between groups for the remaining outcomes, although a small effect size favoring trad was observed for the middle region of the pectoralis major (g = -0.25).It seems that the greater velocity losses during sets observed in traditional-set compared with cluster-set structures may promote superior muscular hypertrophy within specific regions of the pectoralis major in recreationally trained subjects.

Journal: Journal of strength and conditioning research (2022)
Publication types: Journal Article;Randomized Controlled Trial