syedzayyan/paper_mill_benchmark huggingface dataset:
Barriers to and facilitators of return to learning following a sport-related concussion: Perspectives of female secondary school students.

To identify barriers to and facilitators of return to learning (rtl) for female secondary school students following a sport-related concussion (src), and to identify critical junctures on the injury-to-recovery continuum that can be targeted to enhance the rtl process.Design a grounded theory approach using in-depth qualitative interviews.Setting secondary schools within the york region district school board in ontario.Participants ten female secondary school students who presented to a sports medicine physician with an src in 2015 or 2016.Five of the students received a green folder intervention containing an rtl strategy, while 5 students received no rtl intervention following their src.Methods in-depth interviews were conducted in person or by telephone.All interviews were audiorecorded and transcribed.The transcriptions were analyzed, coded, and examined for common themes by 2 independent reviewers.Main findings barriers to rtl included a lack of a graduated rtl process, students' own internal stress, poor communication of expectations, lack of concussion education, and inadequate support from teachers.Facilitators of rtl included academic accommodations and having a primary contact person within the school system.Owing to inconsistent implementation, the impact of the green folder intervention as a facilitator of rtl remains unknown.Conclusion results of this study support existing findings in the realm of concussion research.A novel finding includes the importance of a primary contact person as a facilitator of rtl.This person could help to overcome some of the identified barriers to rtl and improve outcomes by assisting with academic accommodations, providing reassurance regarding these accommodations, improving education among teachers and students, and enhancing communication between stakeholders.

Journal: Canadian family physician Medecin de famille canadien (2022)
Publication types: Journal Article
Social determinants of health associated with the experience of hunger among Brazilian adolescents.

The aim of this study was to identify social determinants of health associated with the experience of hunger among school-age adolescents in brazil.We conducted a cross-sectional study with a sample of 16,526 adolescents using data from the 2015 national school-based student health survey.Experience of hunger was determined based on the answer to the question "in the last 30 days, how often have you been hungry because there wasn't enough food at home?" the social determinants of health were analyzed using poisson regression with robust variance.The prevalence of the experience of hunger was 22.8% (95%ci: 21.9-23.7).The experience of hunger was directly associated with being male (pr = 1.12; 95%ci: 1.07-1.16); not being overweight (pr = 1.08; 95%ci: 1.04-1.13 ); irregular consumption of beans (pr = 1.20; 95%ci: 1.13-1.26), vegetables (pr=1.16; 95%ci: 1.09-1.22) and fruit (pr = 1.19; 95%ci: 1.13-1.24); body dissatisfaction (pr = 1.26; 95%ci: 1.18-1.35); and not regularly eating lunch or dinner with parents or guardians (pr = 1.41; 95%ci: 1.32-1.52).An inverse association was found between the experience of hunger and maternal education level and living in the mid-west, southeast and south.The findings show that the experience of hunger among brazilian adolescents coexists with risky eating behaviors, body dissatisfaction, and social inequality.

Journal: Ciencia & saude coletiva (2022)
Publication types: Journal Article
Disparity in association of obesity measures with ankle and brachial systolic blood pressures in Europeans and South Asians.

Obesity causes increases in brachial systolic-blood-pressures (sbp), risks of type 2 diabetes (t2dm) and cardiovascular diseases (cvd).Brachial and ankle sbps have differential relationship with t2dm and cvd.Our objective was to study the relationship of obesity measures with brachial and ankle sbps.A population of 1098 adults (south asians n = 699; 41.70% male and 58.3% female) were recruited over 5 years from primary care practices in england.Their four limbs sbps were measured using doppler machine and body-mass-index (bmi) and waist-to-height-ratio (wht r) calculated.Linear regressions were performed between sbps and obesity measures, after adjustments for sex, age, ethnicity, t2dm and cvd.The mean age of all participants was 51.3 (sd = 17.2), european was 57.7 (sd 17.2) and south asian was 47.8 (sd = 16.1).The left posterior tibial [beta = 1.179, p = 4.559 × 10-15] and the right posterior tibial sbp [beta = 1.178, p = 1.114 × 10-13] most significantly associated with the bmi.In south asians, although the left brachial [beta = 25.775, p = 0.032] and right brachial sbp [beta = 22.792, p = 0.045] were associated to the wht r, the left posterior tibial sbp [beta = 39.894, p = 0.023], association was the strongest.For the first time, we have demonstrated that ankle sbps had significant association with generalised obesity than brachial systolic blood pressures (sbp), irrespective of ethnicity.However, with respect to visceral obesity, the association with ankle sbp was more significant in south asians compared to europeans.

Journal: Scientific reports (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Changes of Electrocardiogram and Myocardial Enzymes in Patients with Intracerebral Hemorrhage.

Cardiac complications are common in patients with spontaneous intracerebral hemorrhage (ich).The present study is aimed at observing the incidence of cardiac complications after ich, so as at improving the understanding of the relationship between cardiac complications and ich.Methods this is a retrospective study on analyzing electrocardiogram (ecg) and serum myocardial enzyme of 208 patients with ich admitted to a tertiary hospital from 2018 to 2019.For each patient, demographics, medical history, clinical presentation, ecg, serum myocardial enzyme, and head ct on admission were reviewed.Mortality was noted.Results among the 208 patients, 145 (69.71%) had one or more ecg abnormalities.The top three abnormalities were corrected qt interval (qtc) prolongation 52 (25%), st depression 48 (23.08%), and t wave inversion 38 (18.27%).One hundred and thirty-nine patients (66.83%) had increased serum levels of at least one kind of myocardial enzyme, which were high-sensitive cardiac troponin t (hs-c tn t) 79 (37.98%), lactic dehydrogenase (ldh) 80 (38.46%), creatine kinase (ck) 57 (27.40%), and creatine kinase-myocardial subfraction (ckmb) 57 (27.40%).The logistic regression analysis showed the following: secondary intraventricular hemorrhage (sivh) (odds ratio (or) 5.32; 95% confidence interval (ci) 2.55-11.08;p 30 ml (or 3.81; 95% ci 1.86-7.81;p 30 ml (or 24.187; 95% ci 3.14-186.33;p 30 ml (or 1.98; 95% ci 1.06-3.70;p 30 ml, and sivh are the strongest risk factors for ecg abnormalities and elevated myocardial enzymes after ich followed which are the risk factors such as gcs, age, admission blood glucose, and ich location in the thalamus.

Journal: Disease markers (2022)
Publication types: Journal Article
Frame-Based Stereotactic Biopsy - A Single Neurosurgeon Experience of 604 Diagnostic Procedures and Literature Review.

Frame-based stereotactic biopsy (sb) is essential in managing patients with suspected intracranial lesions.This study aimed to evaluate the surgical experience of the senior neurosurgeon to define the lesion, radiology, and technique-related factors that affect the diagnostic yield and complications, along with the literature review.Material and methods documents were examined for consecutively performed frame-based sbs from 1999 to 2021.Procedures that are aimed at nondiagnostic purposes were excluded, thus leaving 604 diagnostic procedures.Diagnostic yield, complication rates, and their relationship with clinical variables were investigated.Results the diagnostic yield was 98%, with a symptomatic hemorrhage rate of 1.2%, a total morbidity rate of 4.8%, and a mortality rate of 0.83%.Larger tumors (odds ratio [or] = 1.350), experienced neurosurgeon (or = 1.339), and pathologist (or = 462.743), and prebiopsy examination with both computed tomography and magnetic resonance imaging (mri) (or = 27.062) were associated with an increased diagnostic yield.None of the parameters were statistically significant for nonhemorrhagic morbidity, whereas the increasing number of specimens (or = 1.395) and glial tumors (or = 3.740) were associated with an increased hemorrhagic risk.Likewise, the increasing number of specimens (or = 2.497) along with the increasing age (or = 14.098) were associated with increased mortality risk.Conclusion knowledge of stereotactic techniques and meticulous surgical planning is required to enhance the diagnostic yield and safety of sb.Considering the results of this largest, mri-guided, single-neurosurgeon sb series, we advocate training neurosurgeons on stereotactic techniques, routine use of intraoperative pathological examination, and working with dedicated neuropathologists when possible.

Journal: Turkish neurosurgery (2022)
Publication types: Journal Article
Electrochemical reduction of nitrate in a catalytic carbon membrane nano-reactor.

Nitrate pollution is a critical environmental issue in need of urgent addressing.Electrochemical reduction is an attractive strategy for treating nitrate due to the environmental friendliness.However, it is still a challenge to achieve the simultaneous high activity and selectivity.Here we report the design of a porous tubular carbon membrane as the electrode deposited with catalysts, which provides a large triple-phase boundary area for nitrate removal reactions.The achieved nitrate removal rate is one order of magnitude higher than other literatures with high nitrate conversion and high selectivity of nitrogen.The carbon membrane itself had a limited catalytic property thus cu-pd bimetal catalysts were deposited inside the nano-pores to enhance the activity and selectivity.When na2so4electrolyte was applied, the achieved single-pass removal of nitrate was increased from 55.15% (for blank membrane) to 97.12% by adding catalysts inside the membrane.In case of na oh as the electrolyte, the single-pass nitrate removal efficiency, selectivity to nitrogen formation and nitrate removal rate was 90.66%, 96.40% and 1.47 × 10-3mmol min-1cm-2, respectively.Density functional theory studies demonstrate that the loading of bimetal catalysts compared with single metal catalysts enhances the adsorption of *no3on membrane surface favorable for n2formation than nh3on cu-pd surface.The application of catalytic carbon membrane nano-reactors can open new windows for nitrate removal due to the high reactor efficiency.

Journal: Water research (2022)
Publication types: Journal Article
The reaction of hydrated iodide I(H2O)-with ozone: a new route to IO2-products.

We report on an experimental characterization of the isolated reaction of hydrated iodide i(h2o)-with ozone o3at room temperature performed using a radio-frequency ion trap combined with a quadrupole mass spectrometer.Contrary to the oxidation reaction of the bare i-ion, the hydrated iodide i(h2o)-primarily reacts to form i-and io2-with significant absolute reaction rate constants of 2.0 ± 0.3 × 10-10cm3molecule-1s-1and 2.5 ± 0.3 × 10-10cm3molecule-1s-1while direct pathways to io-and io3-are much weaker.Quantum chemical calculations indicate that in aqueous phase and for atmospherically relevant temperatures, the presence of hydrated iodides are favored over bare i-ions, thus suggesting that the chemistry of the hydrated ions is relevant for understanding and modeling atmospheric processes at the air-water interface.

Journal: Physical chemistry chemical physics : PCCP (2019)
Publication types: Journal Article
Inhomogeneity of Organically Modified Montmorillonite Revealed by Molecular Dynamics Simulation.

The modification of an interlayer of layered materials by intercalation with an organoammonium ion has been a promising method to control the polarity of the two-dimensional nanospace.Montmorillonite is one of the best-known examples, and the modification with octadecyltrimethylammonium ion (mont-c18) results in adsorption of anthracene and pyrene together with specific excimer emission, while the nanostructure is yet to be uncovered at the molecular level because the gallery height is only ca.27 å.We, herein, investigated the nanostructure of this nanocomposite by molecular dynamics (md) simulation, combined with analysis of molecular orientations against the mont layer.The gallery height of mont-c18was well consistent with the experimental value, which was linearly increased along with the intercalation of anthracene.Anthracene was segregated on the mont layer with its short and long molecular axes vertical in the early and late stages, respectively.In contrast, c18was initially rather horizontal, forming the so-called pseudotrimolecular layer.Pushed out by anthracene, distribution and orientation of c18were gradually changed: the third molecular layer was distinctly observed in the center of the interlayer in the early stage, and the orientation was changed to vertical in the late stage.Thus, the continuous increase in the gallery height is ascribed to soft response of c18to the intercalation.Summarizing the abovementioned results, it was concluded that å-order inhomogeneity is introduced in the interlayer by the intercalation of anthracene, which is significant in ideal design of the two-dimensional nanospace.

Journal: ACS omega (2021)
Publication types: Journal Article
"I Just Want to Feel Safe Going to a Doctor": Experiences of Female Patients with Chronic Conditions in Australia.

The androcentric history of medicine and medical research has led to an ongoing sex and gender gap in health research and education.Sex and gender gaps in research and education may translate into real-life health inequities for women.This study aimed to explore the experiences of female patients with chronic health conditions in the australian health system, considering existing sex and gender gaps in medicine.Methods this qualitative study used semistructured in-depth interviews with a sample of adult women with chronic conditions in australia.Thematic analysis was undertaken, guided by braun and clarke.Software nvivo x64 assisted in the management of the data.Coding was performed before grouping into subthemes and central themes.To allow for potential researcher biases, the principal researcher engaged in the practice of reflexivity, including the writing of detailed notes during analysis.Results twenty adult australian women with chronic conditions were interviewed.Diagnoses were varied and included ehlers-danlos syndrome, chronic fatigue syndrome, functional neurological disorder, and inflammatory bowel disease.Four central themes emerged: diagnostic difficulties; spectrum of health care experiences; understanding medical complexity; and coping with symptoms.Conclusions women with chronic conditions in australia report pain, fatigue, and suffering that significantly impacts upon their daily lives.There was a shared experience of feeling that the pain and suffering of women was dismissed or not taken seriously.Many women expressed trauma because of their experiences in health care and often this led to a fear of accessing health services.The participants highlighted a need for more knowledge, understanding, and empathy from health care practitioners.

Journal: Women's health reports (New Rochelle, N.Y.) (2022)
Publication types: Journal Article
Very low levels of remdesivir resistance in SARS-COV-2 genomes after 18 months of massive usage during the COVID19 pandemic: A GISAID exploratory analysis.

Massive usage of antiviral compounds during a pandemic creates an ideal ground for emergence of resistant strains.Remdesivir, a broad-spectrum inhibitor of the viral rna-dependent rna polymerase (rd rp), was extensively prescribed under emergency use authorization during the first 18 months of the covid19 pandemic, before randomized controlled trials showed poor efficacy in hospitalized patients.Rd rp mutations conferring resistance to remdesivir are well known from in vitro studies, and the huge sars-co v-2 sequencing effort during the ongoing covid19 pandemic represents an unprecedented opportunity to assess emergence and fitness of antiviral resistance in vivo.We mined the gisaid database to extrapolate the frequency of remdesivir escape mutations.Our analysis reveals very low levels of remdesivir resistance worldwide despite massive usage.

Journal: Antiviral research (2022)
Publication types: Journal Article
Decellularized adipose matrix provides an inductive microenvironment for stem cells in tissue regeneration.

Stem cells play a key role in tissue regeneration due to their self-renewal and multidirectional differentiation, which are continuously regulated by signals from the extracellular matrix (ecm) microenvironment.Therefore, the unique biological and physical characteristics of the ecm are important determinants of stem cell behavior.Although the acellular ecm of specific tissues and organs (such as the skin, heart, cartilage, and lung) can mimic the natural microenvironment required for stem cell differentiation, the lack of donor sources restricts their development.With the rapid development of adipose tissue engineering, decellularized adipose matrix (dam) has attracted much attention due to its wide range of sources and good regeneration capacity.Protocols for dam preparation involve various physical, chemical, and biological methods.Different combinations of these methods may have different impacts on the structure and composition of dam, which in turn interfere with the growth and differentiation of stem cells.This is a narrative review about dam.We summarize the methods for decellularizing and sterilizing adipose tissue, and the impact of these methods on the biological and physical properties of dam.In addition, we also analyze the application of different forms of dam with or without stem cells in tissue regeneration (such as adipose tissue), repair (such as wounds, cartilage, bone, and nerves),in vitrobionic systems, clinical trials, and other disease research.

Journal: World journal of stem cells (2020)
Publication types: Journal Article;Review
Using a Spatio-Temporal Basis for ECG Imaging of Ventricular Pacings: Insights From Simulations and First Application to Clinical Data.

Ecg imaging estimates the cardiac electrical activity from body surface potentials.As this involves solving a severly ill-posed problem, additional information is required to get a unique and stable solution.Recent progress is based on introducing more problem-specific information by exploiting the structure of cardiac excitation.However, added information must be either certain or general enough to not impair the solution.We have recently developed a method that uses a spatio-temporal basis to restrict the solution space.In the present work, we analyzed this method with respect to one of the most fundamental assumptions made during basis creation: cardiac (an)isotropy.We tested the reconstruction using simulations of ventricular pacings and then applied it to clinical data.In simulations, the overall median localization error was smallest with a basis including fiber orientation.For the clinical data, however, the overall error was smallest with an isotropic basis.This observation suggests that modeling priors should be introduced with care, whereby further work is needed.

Journal: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference (2019)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Correcting the bias of the net benefit estimator due to right-censored observations.

Generalized pairwise comparisons (gpcs) are a statistical method used in randomized clinical trials to simultaneously analyze several prioritized outcomes.This procedure estimates the net benefit (δ).Δ may be interpreted as the probability for a random patient in the treatment group to have a better overall outcome than a random patient in the control group, minus the probability of the opposite situation.However, the presence of right censoring introduces uninformative pairs that will typically bias the estimate of δ toward 0.We propose a correction to gpcs that estimates the contribution of each uninformative pair based on the average contribution of the informative pairs.The correction can be applied to the analysis of several prioritized outcomes.We perform a simulation study to evaluate the bias associated with this correction.When only one time-to-event outcome was generated, the corrected estimates were unbiased except in the presence of very heavy censoring.The correction had no effect on the power or type-1 error of the tests based on the δ.Finally, we illustrate the impact of the correction using data from two randomized trials.The illustrative datasets showed that the correction had limited impact when the proportion of censored observations was around 20% and was most useful when this proportion was close to 70%.Overall, we propose an estimator for the net benefit that is minimally affected by censoring under the assumption that uninformative pairs are exchangeable with informative pairs.

Journal: Biometrical journal. Biometrische Zeitschrift (2021)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Structure-engineering of core-shell ZnCo2O4@NiO composites for high-performance asymmetric supercapacitors.

The implementation of a structure-designed strategy to construct hierarchical architectures of multicomponent metal oxide-based electrode materials for energy storage devices is in the limelight.Herein, we report ni o nanoflakes impregnated on zn co2o4nanorod arrays as zn co2o4@ni o core-shell structures on a flexible stainless-steel mesh substrate, fabricated by a simple, cost-effective and environmentally friendly reflux condensation method.The core-shell structure of zn co2o4@ni o is used as an electrode material in a supercapacitor as it provides a high specific surface area (134.79 m2g-1) offering high electroactive sites for a redox reaction, reduces the electron and ion diffusion path, and promotes an efficient contact between the electroactive material and electrolyte.The binder-free zn co2o4@ni o electrode delivers a high specific capacitance of 882 f g-1at 4 m a cm-2current density and exhibits remarkable cycling stability (∼85% initial capacitance retention after 5000 charge-discharge cycles at 10 m a cm-2).The asymmetric supercapacitor device zn co2o4@ni o//r go delivered a maximum energy density of 46.66 w h kg-1at a power density of 800 w kg-1.The device exhibited 90.20% capacitance retention after 4000 cycles.These results indicate that the zn co2o4@ni o architecture electrode is a promising functional material for energy storage devices.

Journal: Nanoscale advances (2022)
Publication types: Journal Article