syedzayyan/paper_mill_benchmark huggingface dataset:
The effect of urbanization and industrialization on carbon emissions in Turkey: evidence from ARDL bounds testing procedure.

This paper examines the dynamic short- and long-term relationship between per capita gdp, per capita energy consumption, financial development, urbanization, industrialization, and per capita carbon dioxide (co2) emissions within the framework of the environmental kuznets curve (ekc) hypothesis for turkey covering the period from 1974 to 2013.According to the results of the autoregressive distributed lag bounds testing approach, an increase in per capita gdp, per capita energy consumption, financial development, urbanization, and industrialization has a positive effect on per capita co2emissions in the long term, and also the variables other than urbanization increase per capita co2emissions in the short term.In addition, the findings support the validity of the ekc hypothesis for turkey in the short and long term.However, the turning points obtained from long-term regressions lie outside the sample period.Therefore, as the per capita gdp increases in turkey, per capita co2emissions continue to increase.

Journal: Environmental science and pollution research international (2018)
Publication types: Journal Article
Cost analysis of negative-pressure wound therapy versus standard treatment of acute conflict-related extremity wounds within a randomized controlled trial.

Clinical outcomes after negative-pressure wound therapy (npwt) and standard treatment of conflict-related extremity wounds are similar.In resource-limited settings, cost affects the choice of treatment.We aimed to estimate treatment-related costs of npwt in comparison with standard treatment for conflict-related extremity wounds.Methods we derived outcome data from a randomized, controlled superiority trial that enrolled adult (≥ 18 years) patients with acute (≤ 72 h) conflict-related extremity wounds at two civilian hospitals in jordan and iraq.Primary endpoint was mean treatment-related healthcare costs (adjusted to 2019 us dollars).Results patients were enrolled from june 9, 2015, to october 24, 2018.A total of 165 patients (155 men [93.9%]; 10 women [6.1%]; and median [iqr] age, 28 [21-34] years) were included in the analysis.The cost per patient treated with npwt was $142 above that of standard treatment.Overall, results were robust in a sensitivity analysis.Conclusions with similar clinical outcomes compared to standard care, our results do not support the use of npwt in routine treatment of conflict-related extremity wounds at civilian hospitals in resource scarce settings.Trial registration nct02444598.

Journal: World journal of emergency surgery : WJES (2022)
Publication types: Journal Article;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
Multiple Cerebral Aneurysms Associated With Neurofibromatosis Type 1.

Neurofibromatosis type 1 (nf1) is a rare disease with an incidence of approximately one in every 3000 births.Nf1 is mainly recognized as a tumor suppressor.Vasculopathy in nf1 is well described in the literature, but the association between nf1 and cerebral aneurysm has not been determined.We report a case of a 67-year-old female with nf1 accompanied by 8 cerebral aneurysms.Two of the patient's unruptured aneurysms, the large distal anterior cerebral artery (aca) aneurysm and anterior communicating artery aneurysm, were initially treated with microsurgical clipping.The peripheral aca aneurysm gradually increased in size and ruptured after 5 years.Coil embolization was performed for the ruptured aneurysm.Four of the 5 remaining unruptured aneurysms were treated surgically.The patient is currently well, without neurological deficit, and coil embolization is scheduled for the last remaining aneurysm.Nf1 is a probable risk factor for multiple cerebral aneurysms due to vessel wall vulnerability.Therapeutic indications for patients with nf1 who show multiple cerebral aneurysms include strict follow-up and aggressive treatment to avoid subarachnoid hemorrhage.

Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (2019)
Publication types: Case Reports;Journal Article;Review
Ant Mortality with Food Competition in Forests along a Temperature Gradient.

The authors elucidated the relationship between temperature and mortality due to food competition in ant communities in forests.A field experiment was conducted using four bait types at six different oak forest sites with different mean annual temperatures in south korea.The mortality rate due to food competition showed a hump-shaped trend, with temperature distribution being higher at study sites with intermediate temperatures and a linear trend increasing or decreasing with temperature along the temperature gradient.In most species, the mortality rate due to interspecific competition was higher than that due to intraspecific competition, but the dominant species, which were less affected by other species, had a higher mortality rate due to intraspecific competition.In subordinate species that are highly affected by other species, the mortality rate due to intraspecific competition increased as the mortality rate due to interspecific competition decreased.The results indicated that mortality due to inter- or intraspecific competition for food was associated by temperature, density of other species, and species characteristics (body size, dominance, feeding strategy, and aggressiveness).Given the relationship between temperature and mortality due to food competition, the authors expect that changes in competition due to climate warming will affect the fitness of ant species.

Journal: Insects (2022)
Publication types: Journal Article
Surface charge engineering of Thermomyces lanuginosus lipase improves enzymatic activity and biodiesel synthesis.

S this study was aimed at engineering charged residues on the surface of thermomyces lanuginosus lipase (tll) to obtain tll variant with elevated performance for industrial applications.Results site-directed mutagenesis of eight charged amino acids on the tll surface were conducted and substitutions on the negatively charged residues d111, d158, d165, and e239 were identified with elevated specific activities and biodiesel yields.Synergistic effect was not discovered in the double mutants, d111e/d165e and d165e/e239r, when compared with the corresponding single mutants.One tll mutant, d165e, was identified with increased specific activity (456.60 u/mg), catalytic efficiency (kcat/km: 44.14 s-1m m-1), the highest biodiesel conversion yield (93.56%), and comparable thermostability with that of the tll.Conclusions our study highlighted the importance of surface charge engineering in improving tll activity and biodiesel production, and the resulting tll mutant, d165e, is a promising candidate for biodiesel industry.

Journal: Biotechnology letters (2021)
Publication types: Journal Article
Predicting and improving patient-level antibiotic adherence.

Low adherence to prescribed medications causes substantial health and economic burden.We analyzed primary data from electronic medical records of 250,000 random patients from israel's maccabi healthcare services from 2007 to 2017 to predict whether a patient will purchase a prescribed antibiotic.We developed a decision model to evaluate whether an intervention to improve purchasing adherence is warranted for the patient, considering the cost of the intervention and the cost of non-adherence.The best performing prediction model achieved an average area under the receiver operating characteristic curve (auc) of 0.684, with 82% accuracy in detecting individuals who had less than 50% chance of purchasing a prescribed drug.Using the decision model, an adherence intervention targeted to patients whose predicted purchasing probability is below a specified threshold can increase the number of prescriptions filled while generating significant savings compared to no intervention - on the order of 6.4% savings and 4.0% more prescriptions filled for our dataset.We conclude that analysis of large-scale patient data from electronic medical records can help predict the probability that a patient will purchase a prescribed antibiotic and can provide real-time predictions to physicians, who can then counsel the patient about medication importance.More broadly, in-depth analysis of patient-level data can help shape the next generation of personalized interventions.

Journal: Health care management science (2020)
Publication types: Journal Article
Correlation of Cardiac Output by Arterial Contour-Derived Cardiac Output Monitor Versus Pulmonary Artery Catheter in Liver Transplant: Experience at an Indian Center.

Arterial pulse-derived cardiac output monitors are routinely employed to guide hemodynamic management during liver transplant surgery.In this study, we sought to assess the reliability by evaluating the agreement of the cardiac output measured by the flo trac vigileo versus pulmonary artery catheter (continuous cardiac output) at specified times during liver transplant.Methods liver transplant database with cardiac output values measured by flo trac vigileo and continuous cardiac output was analyzed retrospectively at a tertiary care hospital.Data were compared at t0: baseline, t1: 1 hour in dissection phase, t2: anhepatic phase, t3: portosystemic shunt, t4: reperfusion, t5: 1 hour after reperfusion, and t6: skin closure.Statistical analysis was done using bland-altman analysis and percentage error (<30%) to assess the agreement between cardiac output measured by 2 techniques, lin's concordance correlation coefficient for quantifying the agreement and 4-quadrant plots to compare the trends of cardiac output.Results bland-altman analysis showed mean cardiac output ± standard deviation l min-1 (95% ci) at t0: 0.2 ± 2.09 (-3.9 to 4.3), t1: 0.53 ± 3.0 (-5.4 to 6.4), t2: 0.47 ± 2.1(-3.7 to 4.6), t3: 0.31 ± 1.9 (-3.4 to 4.0), t4: 0.44 ± 2.15 (-3.8 to 4.7), t 5:0.69 ± 1.9.(-2.9 to 4.3), and at t6: 0.43 ± 2.25 (-4.0 to 4.8).Percentage error was 44%-72% and concordance correlation coefficient was poor (<0.65) at all points.Conclusions there is poor agreement between the cardiac output measured by flo trac and pulmonary artery catheter among liver transplant recipients.The need for superior hemodynamic monitoring is mandated in liver transplant.

Journal: Turkish journal of anaesthesiology and reanimation (2022)
Publication types: Journal Article
Identifying mutations in sd1, Pi54 and Pi-ta, and positively selected genes of TN1, the first semidwarf rice in Green Revolution.

Taichung native 1 (tn1) is the first semidwarf rice cultivar that initiated the green revolution.As tn1 is a direct descendant of the dee-geo-woo-gen cultivar, the source of the sd1 semidwarf gene, the sd1 gene can be defined through tn1.Also, tn1 is susceptible to the blast disease and is described as being drought-tolerant.However, genes related to these characteristics of tn1 are unknown.Our aim was to identify and characterize tn1 genes related to these traits.Results aligning the sd1 of tn1 to nipponbare sd1, we found a 382-bp deletion including a frameshift mutation.Sanger sequencing validated this deleted region in sd1, and we proposed a model of the sd1 gene that corrects errors in the literature.We also predicted the blast disease resistant (r) genes of tn1.Orthologues of the r genes in tetep, a well-known resistant cultivar that is commonly used as a donor for breeding new blast resistant cultivars, were then sought in tn1, and if they were present, we looked for mutations.The absence of pi54, a well-known r gene, in tn1 partially explains why tn1 is more susceptible to blast than tetep.We also scanned the tn1 genome using the posi gene software and identified 11 genes deemed to have undergone positive selection.Some of them are associated with drought-resistance and stress response.Conclusions we have redefined the deletion of the sd1 gene in tn1, a direct descendant of the dee-geo-woo-gen cultivar, and have corrected some literature errors.Moreover, we have identified blast resistant genes and positively selected genes, including genes that characterize tn1's blast susceptibility and abiotic stress response.These new findings increase the potential of using tn1 to breed new rice cultivars.

Journal: Botanical studies (2022)
Publication types: Journal Article
High-Throughput Experimentation Using Cell-Free Protein Synthesis Systems.

Cell-free protein synthesis can enable the combinatorial screening of many different components and concentrations.However, manual pipetting methods are unfit to handle many cell-free reactions.Here, we describe a microfluidic method that can generate hundreds of unique submicroliter scale reactions.The method is coupled with a high yield cell-free system that can be applied for broad protein screening assays.

Journal: Methods in molecular biology (Clifton, N.J.) (2022)
Publication types: Journal Article;Research Support, U.S. Gov't, Non-P.H.S.;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't
Family-based whole-exome sequencing identifies rare variants potentially related to cutaneous melanoma predisposition in Brazilian melanoma-prone families.

Genetic predisposition accounts for nearly 10% of all melanoma cases and has been associated with a dozen moderate- to high-penetrance genes, including cdkn2a, cdk4, pot1 and bap1.However, in most melanoma-prone families, the genetic etiology of cancer predisposition remains undetermined.The goal of this study was to identify rare genomic variants associated with cutaneous melanoma susceptibility in melanoma-prone families.Whole-exome sequencing was performed in 2 affected individuals of 5 melanoma-prone families negative for mutations in cdkn2a and cdk4, the major cutaneous melanoma risk genes.A total of 288 rare coding variants shared by the affected relatives of each family were identified, including 7 loss-of-function variants.By performing in silico analyses of gene function, biological pathways, and variant pathogenicity prediction, we underscored the putative role of several genes for melanoma risk, including previously described genes such as myo7a and wrn, as well as new putative candidates, such as serpinb4, hrnr, and nop10.In conclusion, our data revealed rare germline variants in melanoma-prone families contributing with a novel set of potential candidate genes to be further investigated in future studies.

Journal: PloS one (2022)
Publication types: Journal Article;Research Support, Non-U.S. Gov't
Journey to a new era: An innovative academic-practice partnership.

Successful academic-clinical partnerships are mutually beneficial for academic nursing and clinical organizations, supporting the long-term success of nursing programs while simultaneously improving patient outcomes.Advocated by the american association of colleges of nursing in their 2016 report, advancing healthcare transformation: new era for academic nursing, this position paper provides six actions for transforming academic nursing.However, developing sustainable academic-practice models has proven challenging despite this roadmap, as research has not substantiated their benefits.This article describes an innovative academic-practice model that transitioned advanced practice registered nurses practicing at le bonheur children's hospital to full-time faculty, with a continued primary clinical practice role, in the college of nursing at the university of tennessee health science center.We present the origin, development, and implementation of this academic-practice partnership model, offering recommendations for its replication by other universities and clinical agencies on this journey.Creating a sustainable model requires a shared vision, buy-in at all levels, frequent and transparent communication, planning that considers the individual policies of the partnering agencies, and persistence despite leadership changes.Two years into the partnership and remaining intact despite critical leadership changes within the clinical agency, the next phase of the relationship will permit us to document the model's impact on academic and clinical outcomes.

Journal: Journal of professional nursing : official journal of the American Association of Colleges of Nursing (2022)
Publication types: Journal Article
Isolation of GFP-expressing Malarial Hypnozoites by Flow Cytometry Cell Sorting.

Hypnozoites are dormant liver-stage parasites unique to relapsing malarial species, including the important human pathogen plasmodium vivax, and pose a barrier to the elimination of malaria.Little is known regarding the biology of these stages, largely due to their inaccessible location.Hypnozoites can be culturedin vitrobut these cultures always consist of a mixture of hepatocytes, developing forms, and hypnozoites.Here, using a gfp-expressing line of the hypnozoite model parasite plasmodium cynomolgi, we describe a protocol for the facs-based isolation of malarial hypnozoites.The purified hypnozoites can be used for a range of '-omics' studies to dissect the biology of this cryptic stage of the malarial life cycle.

Journal: Bio-protocol (2021)
Publication types: Journal Article
Interventions Designed to Improve Adherence to Growth Hormone Treatment for Pediatric Patients and Their Families: A Narrative Review.

Even though growth hormone (gh) treatment is still the only active treatment option to correct growth failure and increase stature for patients with gh deficiencies, evidence has shown that non-adherence remains high.The aim of this review was to identify and review the existing interventional strategies that have been designed to address and improve adherence to gh treatment for pediatric patients and their families.An extensive search of several electronic databases was undertaken to identify relevant interventional studies, published in english, between 1985 and 2021.Additional search strategies included hand-searching topic review articles to identify eligible studies.Articles were screened against the inclusion eligibility criteria and data on sample characteristics, intervention features, and key findings was extracted.A total of fifteen interventional studies were included in the review.The interventions identified were divided into two broad categories: novel injection devices, and patient choice of device.In conclusions, this review acknowledges that there is a lack of evidence-based, theory-driven intervention strategies, designed with the purpose of optimizing treatment adherence and improve clinical and psychosocial outcomes.

Journal: Pharmaceutics (2022)
Publication types: Journal Article;Review
Immediate Oral Refeeding in Patients With Mild and Moderate Acute Pancreatitis: A Multicenter, Randomized Controlled Trial (PADI trial).

To establish the optimal time to start oral refeeding in mild and moderate acute pancreatitis (ap) to reduce hospital length-of-stay (los) and complications.Summary background data oral diet is essential in mild and moderate ap.The greatest benefits are obtained if refeeding starts early; however, the definition of "early" remains controversial.Methods this multicenter, randomized, controlled trial (nct03829085) included patients with a diagnosis of mild or moderate ap admitted consecutively to 4 hospitals from 2017 to 2019.Patients were randomized into 2 treatment groups: immediate oral refeeding (iorf) and conventional oral refeeding (corf).The iorf group (low-fat-solid diet initiated immediately after hospital admission) was compared to corf group (progressive oral diet was restarted when clinical and laboratory parameters had improved) in terms of los (primary endpoint), pain relapse, diet intolerance, complications, and, hospital costs.Results one hundred and thirty one patients were included for randomization.The mean los for the iorf and corf groups was 3.4 (sd ± 1.7) and 8.8 (sd ± 7.9) days, respectively (p < 0.001).In the corf group alone, pain relapse rate was 16%.There were fewer complications (8% vs 26%) and health costs were twice as low, with a savings of 1325.7€/patient in the iorf than corf group.Conclusions iorf is safe and feasible in mild and moderate ap, resulting in significantly shorter los and cost savings, without causing adverse effects or complications.

Journal: Annals of surgery (2021)
Publication types: Journal Article;Multicenter Study;Randomized Controlled Trial;Research Support, Non-U.S. Gov't
Aortic Arch Stiffness Is Associated With Incipient Brain Injury in Patients With Hypertension.

It has been shown that microstructural brain tissue damage can be detected in hypertension patients, while the underlying mechanisms are not fully understood.We aim to explore the association between diffusion tensor imaging (dti) measures of brain injury and aortic arch pulse wave velocity (pwv) in hypertensive patients without clinically manifest cerebrovascular disease.Methods sixty-six hypertension patients (30 men, mean age 46±14 years) were prospectively included.Aortic arch pwv was assessed using velocity-encoded magnetic resonance imaging (ve-mri).Brain tissue integrity was assessed by using dti.Multivariable linear regression analysis was performed to assess the association between aortic arch pwv and fractional anisotropy (fa), axial diffusivity (ax d), and radial diffusivity (rd).Results increased aortic arch pwv was associated with decreased white matter fa (β = -0.30, p = 0.018), increased gray matter ax d (β = 0.28, p = 0.016), and increased gray and white matter rd (β = 0.30, p = 0.008 and β = 0.35, p = 0.003, respectively).These effects were independent of age, sex, body mass index, smoking, and white matter hyperintensity (wmh) volume.Conclusions aortic arch stiffness relates to incipient brain injury before overt brain abnormalities may become apparent in patients with hypertension.

Journal: American journal of hypertension (2016)
Publication types: Journal Article
Clinical and Genetic Analysis of a Patient with CMT4J.

We report the clinical and genetic analysis of a patient with a rare form of an autosomal recessive genetic neuropathy, charcot marie tooth (cmt) disease type 4j.She presented at age 62 years with signs and symptoms consistent with a mild neuropathy.The onset of symptoms began approximately ten years earlier.Electrophysiological testing confirmed a demyelinating neuropathy and a comprehensive neuropathy screening for common causes of neuropathy was unrevealing.She underwent commercial whole exome sequencing, analyzing more than eighty genes known to cause neuropathy.Two mutations were detected, c.122t > c, p.ile41thr and c.2247dup c, p.ser750gln x10 in the fig4 gene.The p.ile41thr mutation, which is paternally inherited, is a recurrent mutation reported in a number of unrelated families of european descent.The patient’s father, also of european descent, provides further evidence supporting a founder effect for this mutation.In most patients carrying the p.ile41thr mutation, the neuropathy, unlike our patient, is often severe with early onset.The second mutation, c.2247dup c, p.ser750gln x10 is maternally inherited and not previously reported.Furthermore, based upon our protein modeling analysis, c.2247dup c is disease producing, representing a novel pathogenic mutation.Our study of this patient expands the clinical and genetic spectrum of patients with cmt 4j.

Journal: Neurology international (2022)
Publication types: Case Reports;Journal Article