syedzayyan/paper_mill_benchmark huggingface dataset:
Effect of Parecoxib Sodium Combined with Dexmedetomidine on Analgesia and Postoperative Pain of Patients Undergoing Hysteromyomectomy

Propofol combined with remifentanil is the most common anesthesia method in laparoscopic hysteromyomectomy.However, whether the combination of the two is helpful to patients undergoing hysteromyomectomy still requires unclear.Objective.To determine the effect of parecoxib sodium combined with dexmedetomidine on analgesia and postoperative pain of patients undergoing hysteromyomectomy.Methods.Altogether, 72 patients receiving hysteromyomectomy in our hospital from february 2017 to march 2019 were enrolled.Among them, 35 patients treated with parecoxib sodium were assigned to the control group, while the rest 37 patients treated with parecoxib sodium combined with dexmedetomidine were assigned to the research group.The following items of the two groups were evaluated: visual analog scale (vas) score, mechanical pain threshold (mpt), riker sedation-agitation scale (rsas) score, and expression of serum cortisol and melatonin.Results.At 12 and 24 h after operation, the vas score of the research group was lower than that of the control group ( p &lt; 0.05 ), and at 6, 12, and 24 h after operation, the mpt of the research group was notably higher than that of the control group ( p &lt; 0.05 ).In addition, at 10 min after extubation, the research group got notably lower rsas score than the control group ( p &lt; 0.05 ).Before extubation and at 20 min after extubation, the research group showed notably higher melatonin expression and notably lower serum cortisol expression than the control group (both p &lt; 0.05 ).Conclusion.Parecoxib sodium combined with dexmedetomidine can effectively control the postoperative pain of patients undergoing hysteromyomectomy, reduce the incidence of agitation, and effectively control serum cortisol and melatonin in them.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Effect of Observation of Shou Hui Tong Bian Capsule (Polygonum Multiflorum and Aloe-Based Herbal Capsule for Cathartic Effect) in Rapid Rehabilitation of Joint Surgery

To observe the effect of shou hui tong bian capsule (polygonum multiflorum and aloe-based herbal capsule for cathartic effect) in rapid rehabilitation of joint surgery.Methods.A total of 98 patients undergoing perioperative joint surgery in our hospital from july 2019 to march 2020 were included in the study.According to the situation of arthroscopy and joint replacement therapy, the patients were randomly divided into a control group and an observation group, with 49 cases in each group.The control group was treated with conventional therapy.On the basis of the control group, the patients in the observation group were orally administrated with shou hui tong bian capsule, 2 capsules/time, 3 times/day.Both groups received continuous treatment for 14 days.The clinical effects, awakening time, postoperative exhaust time, and the number of patients with different degrees of abdominal distension in the four groups before and after treatment were observed and compared.Results.After treatment, the total effective rate of arthroscopy in the control group was 66.7%, which was significantly lower than 83.3% in the observation group ( p &lt; 0.05 ).The total effective rate of joint replacement in the control group was 64.0%, which was significantly lower than 84.0% in the observation group ( p &lt; 0.05 ).After arthroscopic treatment and joint replacement treatment, the recovery time and postoperative exhaust time of borborygmus in the observation group were significantly lower than those in the control group (both p &lt; 0.05 ).After the treatment, the number of patients with different degrees of abdominal distension in the arthroscopic and joint replacement treatment group and the control group was significantly improved ( p &lt; 0.05 ), and the observation group was significantly better than the control group ( p &lt; 0.05 ).Conclusion.The curative effect of shou hui tong bian capsule on patients undergoing arthroscopic joint surgery and joint replacement during perioperative period is obviously superior to that of conventional treatment.It can effectively improve the total effective rate, shorten the first exhaust time, and increase the number of patients without abdominal distension after treatment.It was safe and effective, and worthy of clinical promotion.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Clinical Study;
Effect of Nursing Outcome-Oriented Intervention on Airway Management in Elderly Long-Term Bedridden Patients

This study intended to explore the nursing outcome-oriented intervention’s effect on airway management in elderly long-term bedridden patients.Methods.A total of 120 cases of elderly long-term bedridden patients admitted to our hospital from may 2018 to june 2020 were enrolled and randomly divided into the observation group ( n = 60 ) and control group ( n = 60 ).The control group received the routine nursing intervention, while the observation group received the nursing outcome-oriented intervention.Forced expiratory volume (fev1), forced vital capacity (fvc), and maximal voluntary ventilation (mvv) in the first second were compared between the two groups before and after the intervention.The pulmonary infection of the two groups was observed.Total protein, hemoglobin, albumin, and cholesterol levels were compared between the two groups.Hamilton anxiety scale (hama) and hamilton depression scale (hamd) were used to evaluate the two groups’ psychological status before and after the intervention.The generic quality of life inventory-74 (gqoli-74) assessed the two groups’ quality of life.Results.After the intervention, the levels of fev1, fvc, and mvv; total protein, hemoglobin, albumin, and cholesterol; and scores of physical function, psychological function, social function, and material life function in the observation group were higher than those in the control group.Pulmonary infection, secondary infection, the infection rate is more than 3%, hama, and hamd scores, and the incidence of pressure ulcers, aspiration, constipation, and the falling bed was lower than those in the control group, with statistical significance (all p &lt; 0.05 ).Conclusion.Nursing outcome-oriented intervention can effectively improve lung function, pulmonary infection, nutritional status, negative mood, and quality of life of long-term bedridden elderly patients.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
Effect of Narrative Nursing Combined with Thinking Map Health Education on Parturient Self-Efficacy and Neonatal Nursing Ability

The motivation behind this study is to explore the influence of narrative nursing combined with thinking map health education on parturient self-efficacy and neonatal nursing ability.To verify this claim, we have selected 60 parturients who were treated in the hospital from february 2019 to april 2021.Moreover, these patients were randomly assigned to control and study groups.The former received narrative nursing, and the latter received narrative nursing combined with thinking map health education.The nursing satisfaction, maternal and neonatal nursing ability, maternal health knowledge awareness score, maternal self-efficacy, anxiety, and depression scores were compared.Initially, we have compared the nursing satisfaction: in the study group, 22 cases were satisfied, 8 cases were basically satisfied, and 0 cases were dissatisfied, and the satisfaction rate was 100.00%; in the control group, 12 cases were satisfied, 14 cases were basically satisfied, and 4 cases were dissatisfied, and the satisfaction rate was 86.67%.The nursing satisfaction in the study group was higher compared to the control group ( p &lt; 0.05 ).Secondly, we compared the mastery of neonatal nursing ability.The study group mastered the relevant knowledge of neonatal nursing in 23 cases, basically mastered 6 cases, and did not master 1 case, with a mastery rate of 96.67%.The control group mastered the knowledge of neonatal nursing in 12 cases, basically mastered 10 cases, and did not master 8 cases with a mastery rate of 73.33%.In the comparison between the two groups, the mastery of neonatal nursing ability in the study group was higher compared to the control group ( p &lt; 0.05 ).Considering the scores of maternal health knowledge, the scores of neonatal basic nursing, physiological characteristics, breastfeeding methods, environmental nursing knowledge, vaccination, and physical examination requirements in the study group were higher compared to the control group ( p &lt; 0.05 ).In the comparison of maternal self-efficacy, the total scores for promoting development, health care, safety, feeding, and self-efficacy in the study group were significantly higher compared to the control group ( p &lt; 0.05 ).Finally, we compared the scores for anxiety and depression.Before nursing, there exhibited no significant difference ( p &gt; 0.05 ).After nursing, the anxiety and depression scores decreased.Furthermore, the anxiety and depression scores of the study group were lower compared to the control group ( p &lt; 0.05 ).In the health education of primary parturient, the adoption of narrative nursing combined with thought guiding schema can enhance the level of nursing satisfaction and self-efficacy, strengthen the nursing ability of primiparas and the awareness rate of health knowledge, and reduce the occurrence of a maternal bad mood, which is more in line with the requirements of parturient.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Clinical Study;
Effect of Modified Xianglian Pingwei Powder plus Glutathione and Levofloxacin Hydrochloride on Patients with Liver Cirrhosis and Positive Small Intestinal Bacterial Overgrowth

Liver cirrhosis is a common chronic disease in china.The effect of modified xianglian pingwei powder plus western medicine in the treatment of liver cirrhosis and positive small intestinal bacterial overgrowth is promising.Totally, 100 patients with liver cirrhosis and positive intestinal bacterial overgrowth in cangzhou central hospital from february 2020 to february 2021 were enrolled and randomized via the random number table method at a ratio of 1 : 1 into the study group and control group.The control group received glutathione and levofloxacin hydrochloride, and the study group received xianglian pingwei powder plus glutathione and levofloxacin hydrochloride.The traditional chinese medicine (tcm) syndrome scores, serum aspartate aminotransferase (ast), alanine aminotransferase (alt), and total bilirubin (tbil) levels of the two groups were decreased after treatment with lower results in the study group.Xianglian pingwei powder plus glutathione and levofloxacin hydrochloride was associated with a significantly lower positive rate of small intestine bacterial growth, serum endotoxin level, and peripheral blood toll-like receptor 2 (tlr2) and trl4 levels versus glutathione and levofloxacin hydrochloride.The combined medication achieved a higher efficacy (90.00%) versus glutathione and levofloxacin hydrochloride (66.00%).The two groups experienced similar safety.Xianglian pingwei powder plus glutathione and levofloxacin hydrochloride achieved significant benefits of clinical efficacy with a high safety profile in patients with liver cirrhosis versus glutathione and levofloxacin hydrochloride.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
Effect of Model Parameters on the Biomechanical Behavior of the Finite Element Cervical Spine Model

Finite element (fe) models have frequently been used to analyze spine biomechanics.Material parameters assigned to fe spine models are generally uncertain, and their effect on the characterization of the spinal components is not clear.In this study, we aimed to analyze the effect of model parameters on the range of motion, stress, and strain responses of a fe cervical spine model.To do so, we created a computed tomography-based fe model that consisted of c2-c3 vertebrae, intervertebral disc, facet joints, and ligaments.A total of 32 fe analyses were carried out for two different elastic modulus equations and four different bone layer numbers under four different loading conditions.We evaluated the effects of elastic modulus equations and layer number on the biomechanical behavior of the fe spine model by taking the range of angular motion, stress, and strain responses into account.We found that the angular motions of the one- and two-layer models had a greater variation than those in the models with four and eight layers.The angular motions obtained for the four- and eight-layer models were almost the same, indicating that the use of a four-layer model would be sufficient to achieve a stress value converging to a certain level as the number of layers increases.We also observed that the equation proposed by gupta and dan (2004) agreed well with the experimental angular motion data.The outcomes of this study are expected to contribute to the determination of the model parameters used in fe spine models.

Journal: Applied Bionics and Biomechanics (2021)
Publication types: Research Article;
Effect of miR-488 on Colon Cancer Biology and Clinical Applications

To explore the expression levels of mi r-488, mi r-29c-3p, and growth differentiation factor 15 (gdf15) in colon cancer tissue and analyze their relationship with clinicopathological features in patients with colon cancer.Methods.The study was conducted from november 2012 to november 2020.A total of 200 patients with colon cancer were treated in our hospital during this period.During the operation, the colon cancer tissues and the adjacent tissues whose distance from the cancer tissues were more than 5 cm were collected, and the expression levels of mi r-488, mi r-29c-3p, and gdf15 m rna in colon cancer tissues were detected by q rt-pcr (real-time fluorescence quantitative).The relationship between them and the clinicopathological features and prognosis of patients with colon cancer were analyzed and discussed.Results.The level of mi r-488 in colon cancer tissues was lower than that in adjacent tissues, but the levels of mi r-29c-3p and gdf15 m rna in colon cancer tissues were higher than those in adjacent tissues ( p &lt; 0.05 ).Compared with paracancerous tissues, the expression rates of mi r-29c-3p and gdf15 protein were higher in colon cancer tissues ( p &lt; 0.05 ).There was no difference in age, sex, tumor location, and tumor diameter between high expression of mi r-488 group and low expression of mi r-488 group ( p &gt; 0.05 ).The degree of differentiation, depth of invasion, tnm stage, lymph node metastasis, and other factors have a direct impact on the level of mi r-488 and the expression of mi r-29c-3p ( p &lt; 0.05 ).The depth of invasion, tnm stage, and lymph node metastasis could affect the expression of gdf15 in patients with colon cancer ( p &lt; 0.05 ).Conclusion.Mi r-488, mi r-29c-3p, and gdf15 in colon cancer tissue are related to the clinicopathological features of patients in varying degrees and may become markers after early warning of colon cancer, which can provide effective guidance for clinical diagnosis and treatment.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Effect of MiR-375 Regulates YAP1 on the Invasion, Apoptosis, and Epithelial-Mesenchymal Transition of Cervical Cancer HeLa Cells

Yes-associated protein 1 (yap1) is an important signaling pathway activator molecule.Studies have shown that it is involved in the occurrence of malignant tumors.This study identified a micro rna (mi r/mi rna) targeting the 3′ untranslated region (3′′ utr) of the yap1 gene and evaluated its biological impact on human cervical cancer cells and related molecular mechanisms.Q pcr and western blotting were used to detect the levels of mi r-375 and yap1 in he la cells.Target scan software was used to identify the binding sites of yap1 and mi r-375.The mtt method was used to determine the viability of he la cells transfected with mi r-375 mimic and yap1 interference vector, the transwell chamber experiment was used to detect the invasion of he la cells after transfection, the apoptosis of he la cells after transfection was detected by flow cytometry, and the western blotting was used to detect the epithelial mesenchymal transition (emt) of he la cells after transfection.The expression of mi r-375 in he la cells was significantly lower than that of normal control cervical cells, and the expression of yap1 in he la cells was significantly higher than that of normal control cervical cells.Target scan analysis showed that mi r-375 was bound to the 3′ utr of yap1.Q pcr and western blot analysis showed that transfection of mi r-375 mimics inhibited yap1 expression in he la cells.Transfection of mi r-375 mimic and yap1 interference vector inhibited he la cell invasion and emt and promoted he la cell apoptosis.These findings indicate that mi r-375 inhibits the malignant development of human cervical cancer cells by regulating the expression of yap1.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Research Article;
Effect of Micropower Vacuum Dressing on Promoting Wound Healing in Patients with I-II Diabetic Foot

Discuss the effectiveness and value of micropower vacuum dressing (mvd) in promoting the healing of i-ii grades diabetic foot wounds.Methods.Sixty patients diagnosed with diabetic foot ulcers and wagner grades i-ii were selected and randomly divided into the control group and experimental group, with 30 cases in each group.The control group was covered with conventional treatments and petrolatum gauze dressings, and the experimental group was treated with mvd on the basis of conventional reatments.The therapeutic effects of the two groups were observed, including healing rate, ulcer area reduction rate, ulcer healing time, dressing change times, ulcer recurrence rate, adverse events, and so on.Results.The healing rate (100%) of the experimental group was higher than that of the control group (56.7%); the wound reduction rate was higher than that of the control group ( p &lt; 0.05 ); the healing time, the number of dressing changes, and the 1-month recurrence rate were all low in the control group ( p &lt; 0.05 ).The incidence of adverse reactions in the experimental group (6.7%) was lower than that in the control group (46.7%) ( p &lt; 0.05 ).Conclusion.Mvd has significant effects in the treatment of i-ii grades diabetic foot wounds and has few adverse reactions.It is an effective new method that can promote the growth of granulation tissue and epithelium and promote wound healing.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Research Article;
Effect of Kangfuxin Solution Fumigation Bath on Postoperative Patients with Hemorrhoid PPH and Influence on the Postoperative Complications

Surgery is now the main clinical treatment for hemorrhoids, and the procedure for prolapse and hemorrhoids (pph) is the commonly used procedure.The key to evaluating the efficacy of surgery includes the quality of postoperative wound healing and the occurrence of complications, so it is especially important to enhance the postoperative rehabilitation of hemorrhoids.This study investigates the method of postoperative treatment with kangfuxin solution fumigation bath to explore the role of this method in the efficacy of patients after hemorrhoid phh surgery and its effect on postoperative complications.It will accumulate some relevant information to improve the efficacy of hemorrhoid surgery and postoperative complications and open new ideas for further postoperative rehabilitation of other diseases in the anal area.A total of 106 patients with hemorrhoids were included in this study, all of whom were treated with phh surgery.After surgery, they were randomly divided into a control group treated with warm water sitz bath and an observation group treated with kangfuxin solution fumigation bath, with 53 cases in each group.We observed all patients’ postoperative pain, bleeding, and perianal edema on a daily basis after surgery; we recorded the time of wound healing and hospital stay.The maximum anal squeeze pressure (masp), anal defecation diastole pressure (addp), anal resting pressure (arp), and the length of the high-pressure zone (hpz) were used as observation indicators to evaluate the anal function of the patients before and after treatment.The results of the evaluation of the efficacy of patients after the treatment period showed that the total effective rate of treatment in the observation group (92.45%) was significantly higher than that of the control group (77.36%).The postoperative recovery showed that the wound healing time, hospitalization time, pain, bleeding, and edema scores at 3 and 5 days after surgery were lower in the observation group than in the control group; masp and arp increased in both groups after treatment compared to before treatment, with more increase in the observation group.The results suggest that patients with hemorrhoids after pph should pay attention to postoperative care and rehabilitation.It also reveals that the application of kangfuxin solution fumigation treatment has a significant effect, which can effectively reduce the patient’s wound healing and hospital stay, while improving the patient’s anal function and reducing postoperative complications, and is worthy of clinical promotion and application.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Research Article;
Effect of Electroacupuncture Combined with Guizhi Gegen Decoction on Cervical Vertigo and Its Influence on TCD of Vertebrobasilar Artery, Blood Rheology Indexes, and Quality of Life

Cervical vertigo is a common clinical disease.In this study, we investigated the clinical efficacy of adding the treatment protocol of gui zhi ge gen tang and electroacupuncture to the western medical treatment in cervical vertigo.The results showed that the total effective rate of the study group was higher than that of the control group p &lt; 0.05 .After treatment, the vertigo, headache, neck and shoulder pain, daily life and work, and psychological and social adjustment scores were higher in the study group than in the control group p &lt; 0.05 .Lva, rva, and vb were higher in the study group than in the control group after treatment p &lt; 0.05 .The whole blood viscosity high cut, whole blood viscosity low cut, and plasma viscosity levels were lower in the study group than in the control group after treatment p &lt; 0.05 .After treatment, pf, rf, re, bp, gh, vt, sf, mh, and ht were higher in the study group than those before treatment p &lt; 0.05 .The incidence of adverse reactions was not statistically significant in the study group compared with the control group p &gt; 0.05 .This means that electroacupuncture combined with gui zhi ge gen tang can effectively increase the blood flow velocity of the vertebrobasilar artery in patients with cervical vertigo and improve their blood rheology and quality of life with definite efficacy and high safety.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Research Article;