syedzayyan/paper_mill_benchmark huggingface dataset:
The Efficacy of Mannitol Combined with 6-Aminocaproic Acid in the Treatment of Patients with Cerebral Hemorrhage and Its Impact on Immune Function

To determine the efficacy of mannitol combined with 6-aminocaproic acid in the treatment of patients with cerebral hemorrhage, as well as its impact on the immune system.Methods.The study subjects consisted of 122 patients with early intracerebral hemorrhage treated in our hospital from april 2019 to april 2022.Based on the different admission times, the participants were randomly divided into the control group and the study group in a ratio of 1:1.6-aminocaproic acid was used to treat patients in the control group, while mannitol along with 6-aminocaproic acid was used to treat patients in the study group.Short form-36 health survey (sf-36) scores, hematoma volume changes, national institutes of health stroke scale (nihss), and mini-mental state examination (mmse) scores, clinical efficacy, and changes in the immune function in patients from the two groups were analyzed and compared.Results.The total efficacy of treatment in the study group was significantly higher than that in the control group (x2 = 9,375, p &lt; 0.001 ).Patients in the study group had significantly higher scores in social function, mental health, physical function, and physiological function compared to those in the control group ( p &lt; 0.05 ).After treatment, there was a significant reduction in nihss scores in patients from both groups, but a greater reduction was seen in patients from the study group ( p &lt; 0.05 ).After 2 weeks of treatment, the volume of cerebral edema was significantly smaller in patients from the study group than in those from the control group ( p &lt; 0.05 ).Before treatment, there was no significant difference in the number of cd4+ and cd8+ t lymphocytes between patients in the two groups.However, after treatment, patients in the study group had higher numbers of cd4+ t lymphocytes and lower numbers of cd8+ t lymphocytes compared to those in the control group ( p &lt; 0.05 ).Conclusions.The combination of mannitol and 6-aminocaproic acid appears to be very efficacious in the treatment of cerebral hemorrhage.It improves immune function, reduces neurological damage, and minimizes the volume of cerebral edema.

Journal: Evidence-Based Complementary and Alternative Medicine (2022)
Publication types: Clinical Study;
The Effect of CT-Guided Artificial Pneumothorax plus Thoracoscopy and Central Venous Catheterization on the Drainage Effect of Pediatric Empyema and Pulmonary Function

The aim of the study is to investigate the effect of ct‐guided artificial pneumothorax combined with a thoracoscopic and central venous catheter on empyema drainage effect and pulmonary function in children.A total of 82 pediatric patients with empyema admitted to our hospital from january 2020 to december 2021 were retrospectively analyzed.The control group was treated with artificial pneumothorax combined with thoracoscopy.The study group was treated with a ct‐guided and central venous catheter.The operation time, intraoperative bleeding, surgical field exposure, wbc, c‐reactive protein, and pulmonary function were compared between the two groups.The size of effusion and sonographic staging were compared between the two groups.All children underwent spirometry and a maximal incremental cardiopulmonary exercise test.The operation indicators (operation time, intraoperative blood loss, etc.) and adverse reactions were compared between the two groups.The differences in the operation time, intraoperative blood loss, postoperative hospital stay, postoperative drainage volume, and surgical field exposure between the two groups had a statistical significance ( p &lt; 0.05); the differences in the body temperature, total peripheral white blood cell count, c‐reactive protein, size of effusion, and sonographic staging between the two groups had no statistical significance ( p &gt; 0.05); before operation, the differences in the expression levels of fvc (%), fev1 (%), fev1/fvc, and mvv (%) and indicators of cardiopulmonary function including ve/vo2, breathing reserve(%), vd/vt(%), and vo2/work between the two groups had no statistical significance, but at 6 months after operation, fvc (%), fev1 (%), fev1/fvc, and mvv (%) in the study group were significantly higher than those in the control group ( p &lt; 0.05) and ve/vo2 and vd/vt(%) in the study group were obviously lower than those in the control group ( p &lt; 0.05); the incidence rate of chest pain, pulmonary edema, and skin infection in the study group was lower than that in the control group ( p &lt; 0.05).Ct‐guided artificial pneumothorax combined with thoracoscopic and central venous catheter drainage of empyema in children is more thorough, with less bleeding, less trauma, rapid recovery of pulmonary function, and is worthy of clinical promotion.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
The Correlation between Obstructive Sleep Apnea and Retinal Vein Obstruction: A Meta-Analysis and Systematic Review

Despite of inadequate evidence, previous studies have demonstrated a potential correlation between obstructive sleep apnea (osa) and retinal vein occlusion (rvo).In this study, a meta‐analysis is conducted to investigate the correlation between osa and rvo.Databases are searched for relevant literatures up to july 14, 2021, including pub med, embase, cochrane, web of science, cnki, wan fang, vip, and chinese biomedical literature database (cbm).The odds ratio (or) and 95% confidence interval (ci) are estimated to evaluate the correlation between osa and rvo.Six articles were finally enrolled, including 36,086 subjects from 5 case‐controlled studies and 1 cohort study.It is clearly evident that the rvo risk is higher among osa patients than non‐osa patients (or = 3.24, 95% ci = 3.24).The results of sensitivity analysis indicate that the present meta‐analysis is robust and reliable.Furthermore, egger's test for publication bias is performed with p = 0.195, and the results reveal no significant publication bias.The findings demonstrate that osa is significantly correlated with rvo, and osa is a risk factor for rvo.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Meta-Analysis;
The Comparison of Life Quality between Ultrasound-Guided High-Intensity Focused Ultrasound and Laparoscopic Myomectomy for the Treatment of Uterine Fibroids

This study is aimed at comparing the uterine fibroids patients’ postoperative living quality between ultrasound-guided high-intensity focused ultrasound (hifu) and laparoscopic myomectomy.Materials and methods.A total of 164 patients were included with uterine fibroids who underwent laparoscopic myomectomy and hifu in cangzhou central hospital from september 2020 to november 2021.This study divided these objects into hifu group and laparoscopic group, and both groups were followed up 6 months after surgery.After obtaining the results, uterine fibroid symptom and health-related quality of life questionnaire (ufs-qol) and 36-item short form health survey (sf-36) were performed before and after treatment to assess patient outcome.Results.After treatments, the living quality in both groups was significantly improved compared with that before surgery, which had statistical significant ( p &lt; 0.05 ).After treatment, the scores of the two scales in hifu group were significantly better than those in the laparoscopic group ( p &lt; 0.05 ).Conclusion.In comparison with laparoscopic myomectomy, ultrasound-guided high-intensity focused ultrasound could improve the life quality of patients more effectively than traditional laparoscopic myomectomy and was helpful to the recovery and prognosis of uterine fibroids after treatment.The outcomes will provide a reference for clinicians to select a more appropriate treatment for uterine fibroids.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Clinical Study;
TAP Test Image Dynamic Tracking Study after Thyroid Cancer Surgery and after Radiotherapy and Chemotherapy

Thyroid cancer is a relatively common endocrine gland malignant tumor; if improper treatment, there will be a high risk of recurrence or metastasis, and abnormal sugar chain glycoprotein (tap) has a close relationship with the development of the disease; therefore, the purpose of this article is to discuss abnormal sugar chain glycoprotein (tap) as thyroid cancer curative effect evaluation and radiation and chemotherapy after surgery clinical significance.In this paper, 95 patients with thyroid cancer diagnosed in a hospital were selected as the study objects and treated as the observation group.The clinical and follow-up data of the observation group were retrospectively analyzed.Meanwhile, 55 healthy patients were randomly selected as the control group.Tap, squamous cell carcinoma antigen (scc) level, and carcinoembryonic antigen (cea) level were detected in peripheral blood of 95 patients with thyroid cancer before and after treatment.The short-term efficacy was evaluated by chest ct examination, and the changes of the three markers before and after treatment and the correlation with the short-term efficacy of the patients were compared.According to the results of testing, the tap positive expression in patients before radiotherapy can better predict the recent curative effect has certain clinical value; before radiotherapy tap positive expression rate was significantly higher than that of healthy people, tap positive expression quantity decreased obviously after radiation treatment, and patients with a recent radiotherapy curative effect is good or bad and negatively correlated with the degree of tap protein positive expression; tap high protein in patients with recent poor radiation effects, prompt the factor can be predicted in the near future curative effect of the molecular markers, and can tap level for clinicians provide certain reference for targeted therapy.

Journal: Computational and Mathematical Methods in Medicine (2021)
Publication types: Research Article;
Systematic Analysis of Tumor Microenvironment Patterns and Oxidative Stress Characteristics of Endometrial Carcinoma Mediated by 5-Methylcytosine Regulators

As a widely distributed rna methylation modification, m5c is involved in the regulation of tumorigenesis.Nevertheless, its fundamental process is not clear.This research sought to examine the genetic properties of the 5-methylcytosine (m5c) regulator in endometrial carcinoma, as well as the prognostic significance and impact of m5c regulators on oxidative stress.Therefore, the tcga-ucec data set was used to explore the characteristics of 17 rnam5c-related genes in the transcriptome, genome, and regulatory network.The subtypes of rnam5c in ucec were identified based on the expression levels of 17 rnam5c-related genes.The prognosis of rnam5c-2 was significantly better than that of rnam5c-1.Then, we examined the differences (variations) across various subtypes in terms of immune cell infiltration (ici) as well as the expression of immune-related signal markers.The findings demonstrated that there were distinct variations in the infiltration level of immune cells in each subtype, which may be the reason for the differences in the prognosis of each subtype.In addition, the differentially expressed genes (degs) among rnam5c subtypes of different ucec tumors were identified, and the degs significant for survival were screened.After obtaining 34 prognostic genes, the dimensionality was reduced to construct an rna methylation score (rs).As per the findings, rs is a more accurate marker for determining the prognosis for patients with endometrial cancer.The rs was used to categorize ucec tumor samples, and these results led to the formation of high-score and low-score groups.The patients in the group with a high-rna methylation score exhibited a survival time that was considerably longer in contrast with those in the group with a low-rna methylation score.The capacity of rs to predict whether or not immunotherapy would be beneficial was explored further.In the group with a high-rna methylation score, the objective response rate to the anti-pd-l1 therapy was substantially greater compared to that observed in the subgroup with a low-rna methylation score.Additionally, there were variations across various rs groups in terms of clinical features, tumor mutation burden, and the infiltration level of immune cells.After binary tree analysis and pcr verification of 34 prognostic genes, it is finally found that the six genes of magoh3p, trbj2_3, ythdf1p1, rp11_323d18.5, rp11_405m12.2, and adam30 are significantly overexpressed in cancer tissues.These genes can be used as potential biomarkers of endometrial cancer and provide data support for precise immunotherapy in ucec tumors.

Journal: Oxidative Medicine and Cellular Longevity (2022)
Publication types: Research Article;
Study on the Relationship between Unexplained Recurrent Abortion and HLA-DQ Gene Polymorphism

The study aimed to investigate the relationship between human leukocyte antigen (hla-dqb1) gene variants and recurrent miscarriage.Methods.Hla-dq gene polymorphisms (pcr-ssp) were detected in 50 couples with recurrent miscarriage (ursa group) and 30 couples with normal births (control group) using sequence-specific primer-guided polymerase chain reaction.Results.The frequency of the dqb1 ∗ 0303 allele in the ursa group (21.50%) was substantially higher than that of the control group (11.67%) ( p = 0.0260 0.05, rr = 1.754); however, the frequency of the dqb1 ∗ 0302 allele in the ursa group (4.00%) was substantially lower than that of the control pair (10.00%) ( p = 0.0318 0.05, rr = 0.400); the frequency of sharing one allele was 46.00% (23/50) in the ursa group and 0.00% (0/30) in the normal control group; the frequency of sharing two alleles was 40.00% (2/50) in the ursa group and 43.33% (13/30) in the normal control group, with no significant difference between the two groups.Conclusion.For the zhejiang population, hla-dqb1 ∗ 0303 may be a susceptibility gene for recurrent miscarriage, while hla-dqb1 ∗ 0302 may be protective against recurrent miscarriage, especially for women.

Journal: Computational Intelligence and Neuroscience (2022)
Publication types: Research Article;
Study on the Correlation between the Prevalence of Venous Thromboembolism in Kazak Pregnant and Lying-In Women in Xinjiang

In order to reveal the correlation between the prevalence of venous thromboembolism in kazak pregnant and lying‐in women in xinjiang, the polymorphisms in the promoter region and coding region of the tafi gene and the interaction of environmental factors are investigated.In this study, determination and analysis of anticoagulation indexes are conducted.The activity of antithrombin iii and protein c is measured by chromogenic substrate method, and the activity of protein s is measured by coagulation method.Besides, the detection of apc‐r is performed by apc‐aptt method.The experimental results show that the prevalence rate of hereditary thrombophilia + dvt among kazak pregnant women in xinjiang is 33.8%, and the prevalence rates of at‐iii deficiency, pc deficiency, ps deficiency, apcr, and hcy are 17.5%, 16.7%, 22.0%, 23.7%, and 26.8%, respectively.Also, the genotype frequency and allele frequency distribution of each group are in line with hardy–weinberg equilibrium ( p &gt; 0.05).The comparison result indicates that the gene frequency has reached a genetic balance and is representative of the population.It is clearly evident that the polymorphisms of prothrombin gene rs3136447 and rs5896 may be associated with hereditary thrombophilia in xinjiang kazaks.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Serum MMP-9 and SAA in the Diagnosis of Severe Pneumonia Caused by Radiotherapy of Esophageal Cancer

To explore the relationship and diagnostic value of serum mmp-9 and saa in severe pneumonia (s cap) caused by radiotherapy of esophageal cancer.Methods.A total of 144 esophageal cancer patients who underwent radiotherapy in our hospital from april 2016 to february 2018 were collected.Among them, 58 patients without radiation pneumonitis (rp) were in the control group, 49 patients with grade 1∼2 rp were in the radiation group, and 37 patients with s cap were in the severe group.The levels of serum mmp-9 and saa in every group of patients were detected.The roc curve was used to determine the diagnostic value of serum mmp-9 and saa in the diagnosis of rp and s cap.The correlation between serum mmp-9 and saa and the patient’s lung function indexes was analyzed, and the logistic single-factor and multivariate analyses were performed to analyze the factors of s cap in esophageal cancer radiotherapy.Results.Pa o2, fvc, and fev1 decreased in rp and s cap, and pa co2, white blood cells, serum mmp-9, and saa levels increased ( p &lt; 0.05 ); serum mmp-9 and saa were negatively correlated with lung function ( p &lt; 0.05 ); the auc of serum mmp-9 and saa in rp was 0.833 and 0.823, respectively, and the auc of the two combined diagnosis of rp was 0.919.The auc of serum mmp-9 and saa in s cap was 0.809 and 0.797, respectively, and the auc of both combined diagnosis of s cap was 0.873; logistics multivariate analysis found that serum mmp-9, serum saa, double lung v5, and v20 were independent risk factors for s cap caused by radiotherapy for esophageal cancer ( p &lt; 0.05 ).Conclusion.Serum mmp-9 and saa increase in rp and s cap and are negatively correlated with lung function in patients with pneumonia.They are independent risk factors for severe pneumonia caused by radiotherapy of esophageal cancer and have good diagnostic value.

Journal: Evidence-Based Complementary and Alternative Medicine (2021)
Publication types: Research Article;
Serum Expression Level of MicroRNA-122 and Its Significance in Patients with Hepatitis B Virus Infection

S.To analyze the expression of mi r-122 and evaluate its significance in patients with hbv infection in different phases.Methods.Eleven chronic hepatitis b (chb), 26 hepatitis b virus (hbv)-induced cirrhosis, 16 hbv-associated hepatocellular carcinoma (hcc) patients and 10 healthy control cases were enrolled.The serum levels of mi r-122 were detected by rt-pcr and compared between healthy individuals and chb at different stages.Results.Compared with healthy control cases, serum mi r-122 levels were markedly increased in hbv infection cases (auc = 0.795, p = 0.002 ).In the chb group, mi r-122 levels were positively associated with albumin levels ( p &lt; 0.05 ) but had no significant associations with alanine aminotransferase (alt) and aspartate aminotransferase (ast) ( p &gt; 0.05 ).In the cirrhosis group, mi r-122 expression was remarkably lower in the child c group in comparison with the child a group ( p = 0.025 ).At the same time, mi r-122 amounts had a negative correlation with hvpg ( p &lt; 0.05 ).In the hcc group, mi r-122 amounts were negatively associated with alkaline phosphatase (akp) and alpha-fetoprotein (afp) ( p &lt; 0.05 ).Serum mi r-122 amounts in 3 patients who died were lower than the survival group (5.520 ± 0.522 vs.5.860 ± 1.183, p &gt; 0.05 ).Conclusion.Serum mi r-122 can be leveraged to screen patients with hbv infection.In hbv sufferers, the serum mi r-122 expression level is related to liver disease progression, hence making it an underlying molecular biomarker for predicting the development of chb.

Journal: Journal of Healthcare Engineering (2022)
Publication types: Research Article;
Risk Factors for Pulmonary Metastasis in Differentiated Thyroid Carcinoma Patients and the Significance of Changes in Matrix Metalloproteinase 13 and microRNA-142 Levels

This work aims to explore the risk factors of lung metastasis (lm) in differentiated thyroid cancer (dtc) (lm‐dtc) and the effect of treatment and to detect the relationship between lm‐dtc and the levels of matrix metalloproteinase‐13 (mmp‐13) and micro ribonucleic acid (rna)‐142 (mi r‐142) in peripheral blood.The data of 420 patients with dtc who are admitted from march 2020 to december 2021 are collected and divided into a non‐metastasis group (non‐lm group) of 400 cases and metastasis group (lm group) of 20 cases according whether the mung metastasis is found.In addition, risk factors of lm‐dtc are analysed and compared.The results of multivariate logistic analysis show that age, disease course, and imaging timing are independent influencing factors of the radionuclide treatment effect.Follicular carcinoma, abnormal expressions of mmp‐13, and mi r‐142 can increase the risk of lm‐dtc.Mmp‐13 and mi r‐142 can be undertaken as auxiliary diagnostic biological indicators.

Journal: Contrast Media & Molecular Imaging (2022)
Publication types: Research Article;
Renoprotective Effect of Intraoperative Dexmedetomidine in Renal Transplantation

Renal dysfunction after kidney transplantation may be influenced by many reasons.This study was designed to evaluate whether the administration of dexmedetomidine (dex) could ameliorate renal function and prognosis after kidney transplantation.Methods.A total of 65 patients were divided into dex group ( n = 33 ) and con group (con, n = 32 ).Dex group intravenously received an initial loading dose of 0.6 μg/kg dex for 15 min before anaesthesia induction, followed by a rate of 0.4 μg/kg/h until 30 min after kidney reperfusion.By contrast, con group received saline.The concentration of urinary kidney injury molecule-1 (kim-1), serum creatinine (cr), blood urea, urine output, β2 microglobulin (β2-mg), cystatin c (cys c), and estimated glomerular filtration rate (e gfr) was recorded and compared between two groups during the course of the hospitalization or follow-up.Mean arterial pressure (map) and heart rate (hr), vasoactive drugs, and anaesthetics were recorded during the operation.Pain degree was evaluated using a visual analogue scale (vas) after operation.Delayed graft function (dgf), graft loss, length of hospital stay, and mortality were compared between groups.Results.The concentration of kim-1 in dex group was lower than con group at 2 h ( p = 0.018 ), 24 h ( p = 0.013 ), 48 h ( p &lt; 0.01 ), and 72 h ( p &lt; 0.01 ) after reperfusion.Map of dex group after tracheal intubation ( p = 0.012 ) and incision ( p = 0.018 ) and hr after intubation ( p = 0.021 ) were lower than that of con group.The dosage of sufentanil during operation in dex group was less than con group ( p = 0.039 ).Patients that used atropine in dex group were more than con group ( p = 0.027 ).Patients who received dex presented with lower vas scores at 6 h ( p = 0.01 ) and 12 h ( p = 0.002 ) after operation.Concentration of serum cr and blood urea had no significant differences between groups before operation and on postoperative day 1 to 6.Urine output was recorded for 6 days after operation and had no differences between groups.Also, no differences were identified between two groups in urea, cr, β2-mg, cys c, and e gfr in the first 3 months after operation.Incidence of dgf after operation was detected no difference between groups, while length of hospital stay in dex group was less than con group ( p = 0.012 ).Conclusion.Dex can decrease kidney injury marker level, attenuate perioperative stress, relieve the dosage of sufentanil and postoperative pain, and reduce length of hospital stay.However, dex is not associated with changes in prognosis in the first 3 months after transplantation.

Journal: Computational and Mathematical Methods in Medicine (2022)
Publication types: Research Article;