The severe weather episode began as a series of supercells and transitioned to a squall line. A supercell thunderstorm produced a strong long-track tornado across southeast Missouri that ended in southwest Perry County. A short EF-1 tornado associated with a squall line struck southern Perry County shortly thereafter. A longer track EF-1 tornado also impacted eastern Wayne County into southern Bollinger County. The storms preceded a strong cold front that trailed south-southwest from a low pressure center over west central Illinois. Dew points ahead of the front were in the lower to mid 60's. Instability was strong enough to support severe storms, given that wind shear was quite strong. Mixed-layer capes were around 1000 j/kg.

Tornado in PERRY, MISSOURI
From 24-OCT-21 20:09:00 to 24-OCT-21 20:15:00 (CST-6)
Location: BARKS
Tornado F-scale: EF2
Property damage: 200.00K
Crop damage: 0.00K
Reported by: NWS Storm Survey

This long-track tornado crossed into southwest Perry County from Madison County. Along the Madison/Perry county line, the width was about half of a mile wide, with numerous trees snapped and uprooted. The tornado then moved nearly parallel to County Road 738. Here several houses and a hunting lodge sustained minor damage, mainly to roofs and posts of a porch. One barn and a small shed were destroyed, along with numerous  uprooted and snapped trees. The tornado continued on to produce tree damage on Highway 730, where it was only a few hundred yards wide and dissipated shortly thereafter. Peak winds in the Perry County portion of the path were near 112 mph, putting it barely into the EF-2 category. However, the tornado peaked at EF-3 intensity earlier in its life cycle.

Tornado in PERRY, MISSOURI
From 24-OCT-21 20:42:00 to 24-OCT-21 20:45:00 (CST-6)
Location: YOUNT
Tornado F-scale: EF1
Property damage: 10.00K
Crop damage: 0.00K
Reported by: NWS Storm Survey

This short-lived tornado occurred in sparsely populated country near the tiny community of Yount. The tornado crossed Highway J three times, snapping and uprooting trees along its path.

Thunderstorm Wind in PERRY, MISSOURI
From 24-OCT-21 21:00:00 to 24-OCT-21 21:00:00 (CST-6)
Location: PERRYVILLE
Magnitude: 52.00 EG
Property damage: 0.00K
Crop damage: 0.00K
Reported by: Trained Spotter

A trained spotter reported 50 to 60 mph winds.

Tornado in WAYNE, MISSOURI
From 24-OCT-21 22:04:00 to 24-OCT-21 22:08:00 (CST-6)
Location: SHOOK
Tornado F-scale: EF1
Property damage: 20.00K
Crop damage: 0.00K
Reported by: NWS Storm Survey

This tornado touched down in the heavily forested county of Wayne, just a few miles north of the community of Shook. Numerous trees were uprooted and snapped. The tornado passed mainly through wooded country during the Wayne County portion of its path. The tornado then crossed into Bollinger County.

Tornado in BOLLINGER, MISSOURI
From 24-OCT-21 22:08:00 to 24-OCT-21 22:30:00 (CST-6)
Location: GIPSY
Tornado F-scale: EF1
Property damage: 400.00K
Crop damage: 0.00K
Reported by: NWS Storm Survey

The tornado crossed into Bollinger County from Wayne County. The tornado directly affected the community of Zalma, where the school gymnasium roof was damaged. Air conditioning units were blown off the school roof. The top half of a two-story barn was destroyed. There was roof damage to a chicken house. Otherwise, the majority of the path was through densely wooded farm country, where numerous trees were uprooted or snapped. Peak winds were estimated near 105 mph.

Hail in PERRY, MISSOURI
From 24-OCT-21 21:00:00 to 24-OCT-21 21:00:00 (CST-6)
Location: PERRYVILLE
Magnitude: 0.75 
Property damage: 0.00K
Crop damage: 0.00K
Reported by: Trained Spotter

Thunderstorm Wind in PERRY, MISSOURI
From 24-OCT-21 20:04:00 to 24-OCT-21 20:04:00 (CST-6)
Location: LITHIUM
Magnitude: 56.00 EG
Property damage: 5.00K
Crop damage: 0.00K
Reported by: Trained Spotter

A trained spotter just south of St. Mary reported a lot of tree damage on the road.

Flash Flood in BOLLINGER, MISSOURI
From 24-OCT-21 22:45:00 to 25-OCT-21 00:45:00 (CST-6)
Location: SCOPUS
Flood cause: Heavy Rain
Property damage: 0.00K
Crop damage: 0.00K
Reported by: Trained Spotter

There was water and debris over Highway B and County Road 324.  Hog Creek was out of its banks along Highway B.

Thunderstorm Wind in NEW MADRID, MISSOURI
From 25-OCT-21 00:00:00 to 25-OCT-21 00:00:00 (CST-6)
Location: NEW MADRID
Magnitude: 52.00 EG
Property damage: 25.00K
Crop damage: 0.00K
Reported by: Emergency Manager

The roof of an old, vacant, dilapidated apartment building was damaged. Part of the roof was ripped off the one-story building, landing on the wall of a neighboring residence. Some branches were down elsewhere in the city.