December 10, 2021, was unseasonably warm over the region. Temperatures broke several long-standing records. Memphis hit 80��F which broke a 103-year-old high-temperature record.
A strong upper-level trough was approaching from the west, providing strong lift within the unseasonably warm and unstable air mass.  MLCAPE reached the 1500-2000 J/kg range by 6 PM. The wind field was impressive with plenty of vertical wind shear needed for organized thunderstorms. Effective 0-1 km storm-relative helicity values ranged from 300-400 m2/s2 with effective bulk shear values of 70 knots - more than sufficient to support discrete supercells in the warm sector ahead of the cold front.
The first supercell developed in central Arkansas and tracked into northeast Arkansas producing a few weak tornadoes initially before intensifying across eastern Craighead and Mississippi Counties and killing two people. The tornado eventually strengthened into an EF-4 while moving through the Missouri Bootheel, resulting in 2 direct and one indirect fatality in Pemiscot County. The tornado then tracked across the Mississippi River into northwest Tennessee, producing an additional 4 fatalities near Reelfoot Lake. This tornado lifted for a brief time in Obion County, reorganized, and then moved into Kentucky. All told, the mesocyclone tracked for over 300 miles and was producing tornadoes for over 250 miles. This storm was responsible for at least 9 fatalities and many injuries in the NWS Memphis CWA along with millions of dollars of damage.
As the initial supercell was crossing the state line into Kentucky, a string of supercells was moving into eastern Arkansas. A few brief tornadoes produced minor damage near Cash in western Craighead County and in the Fisher area of western Poinsett County. As the dominant supercell moved into eastern Poinsett County, the mesocyclone quickly intensified and the storm produced an EF-2 tornado in Trumann with several injuries and widespread damage.
A new supercell developed in Mississippi County causing straight-line wind damage initially. This supercell intensified as it crossed the Mississippi River and produced another long-track tornado starting in Dyer County,  Tennessee. This tornado tracked east-northeast across northwest Tennessee into Henry County, and eventually into Kentucky. This tornado was rated EF-3 and resulted in several injuries with Kenton and Dresden, Tennessee being the hardest hit.
The convection eventually evolved into a QLCS as it moved east. A mesovortex developed south of I-40 near Jackson that resulted in 3 tornadoes across eastern Madison, Henderson, and Decatur Counties including an EF-2. Non-tornadic storms moved across the Memphis metropolitan area, producing straight-line wind damage as a mesovortex moved through the city. A fatality was reported in Shelby County after a large tree fell on a home in South Memphis. Later that night, an EF-1 tornado occurred in Prentiss County before the severe weather threat began to wind down around 6 AM on December 11, 2021.
In total, there were 18 tornadoes across the NWS Memphis CWA.  Along with tornadoes, several incidents of wind damage and minor flash flooding also occurred.

Strong Wind in DE SOTO, MISSISSIPPI
From 10-DEC-21 21:00:00 to 11-DEC-21 01:00:00 (CST-6)
Magnitude: 38.00 MG
Property damage: 10.00K
Crop damage: 0.00K
Reported by: Emergency Manager

Strong gradient winds ahead of an approaching cold front knocked down a few trees across DeSoto County.

Thunderstorm Wind in DE SOTO, MISSISSIPPI
From 11-DEC-21 01:18:00 to 11-DEC-21 01:23:00 (CST-6)
Location: OLIVE BRANCH
Magnitude: 50.00 EG
Property damage: 2.00K
Crop damage: 0.00K
Reported by: Broadcast Media

A large tree was knocked down in Olive Branch.

Thunderstorm Wind in TISHOMINGO, MISSISSIPPI
From 11-DEC-21 05:15:00 to 11-DEC-21 05:20:00 (CST-6)
Location: BELMONT
Magnitude: 56.00 EG
Crop damage: 0.00K
Reported by: Local Official

Numerous trees were knocked down across Belmont resulting in several road closures.

Tornado in PRENTISS, MISSISSIPPI
From 11-DEC-21 04:30:00 to 11-DEC-21 04:35:00 (CST-6)
Location: MARIETTA
Tornado F-scale: EF1
Property damage: 125.00K
Crop damage: 0.00K
Reported by: NWS Storm Survey

NWS meteorologists surveyed storm damage in the area of Marietta, MS in Prentiss County and determined it was the result of a tornado. The tornado began in a field along HWY 371 just south of MS-4 East. As the tornado tracked northeastward, hardwood and softwood trees were uprooted with a few snapped trunks. The worst damage occurred along CR 4111, where a site-built home had a large section of roof blown off and a carport totally destroyed. Nearby damage consisted of a narrow path of uprooted trees and a few snapped trunks. It is along this portion of the track that the tornado was given a peak rating of EF-1. Just down the road, a mobile home had a section of peeled roof. The tornado then paralleled CR 3401 to the south, with a narrow but visible path of uprooted trees with some snapped trunks as the circulation cut across tree lines between fields. The final area of structural damage was along CR 3461 where a mobile home had a section of roof peeled back. A few nearby trees were also uprooted just northeast of the home with dissipation of the tornado apparent shortly thereafter. Peak winds estimated at 95 mph.

Thunderstorm Wind in ITAWAMBA, MISSISSIPPI
From 11-DEC-21 05:00:00 to 11-DEC-21 05:05:00 (CST-6)
Location: MANTACHIE
Magnitude: 50.00 EG
Property damage: 2.00K
Crop damage: 0.00K
Reported by: Emergency Manager

A large tree was knocked down on River Road near Mantachie.