sujigwak/NVAR huggingface dataset:
UniProt ID: Q52126
Variant: T -> M at position 264-264
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: G -> S at position 270-270
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: I -> V at position 276-276
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: L -> I at position 285-285
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52657
Variant: N -> NN at position 60-60
Variant annotation: in strain: Indian tick typhus
Protein function: Elicits protective immunity.
Reference sequence:
MANISPKLFQKAIQQGLKAALFTTSTAAIMLSSSGALGIAVSGVIATNNNAAFSDNVGNNWNEITAAGVANGTPARGPQNNWAFTYGGDYTITADVADHIITAINVADTTPIGLNIAQNTVVGSIVTGGNLLPVTITAGKSLTLNGNNADAANHGFGAPADNYTGLGNIALGGANAALIIQSAAPAKITLAGNINGGGIITVKTDAAINGTIGNTNALATVNVGAGIATLEGAIIKATTTKLTNAASVLTLTNVNAVLTGAIDNTTGVDNVGVLNLNGALSQVTGNIGNTNALATISVGAGKATLGGAVIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGNSTVTGNIGNTNALATVNVGAGIATLEGAVIKATTTKLTNAASVLTLTNVNAVLTGAIDNTTGVDNVGVLNLNGALSQVTGNIGNTNALATISVGAGKATLGGAVIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIATFTGDSTVTGNIGNTNALATVNVGAGLLRVQGGVVKSNTINLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATVNVGAGVTLQAGGSLDANNIDFGARSTLEFNGPLDGGGNAIPYYFKGAIANGNNAILNVNTKLLTAYHLTIGTVAEINIGAGNLFAIDASAGDVTILNAQDIHFRALDSALVLSNLTGVGVNNILLAADLVAPGVDEGTVVFDGGVNGLNIGSNVAGAARNIGDVGGNKFNTLLIYNAVTITDDVNLEGIQNVLINNNADFTSSTAFNAGTIQINDATYTIDANNGNLNIPAGNIKFAHADAQLILQNSSGNDRTITLGANIDPDNDDEGIVILNSVTAGKKLTIAGGKTFGGAHKLQDIVFKGEGDFGTAGTTFNTTNIVLDITGQLELGATTANVVLFKDAVQLTQTGNIGGFLDFNAKNGTVTLNNNVNVAGTVKNTGGTNNGTLIVLGASNLNRVNGIAMLKVGAGNVTIAKGGNVKIGEIQGTGTNTLTLPAHFKLTGSINKTGGQALKLNFMNGGSVSGVVGTAANSVGDITTAGATSFASSVNAKGTATLGGTTSFAHTFTNTGAVTLAKGSITSFAKNVTATSFVANSATINFGNSLAFNSNITGSGTTLTLGANQVTYTGTGSFTDTLTLNTTFDGAAKSGGNILIKSGSTLDLSGVSNLALVVTATNFDMNNISPDTKYTVISAETAGGLKPTPKENVKITINNDNRFVDFTFDASTLTLFAEDIAAGVIDEDFAPGGPLANIPNAANIKKSLELMEDAPNGSDARQAFNNFGLMTPLQEADATTHLMQDVVKPSDTIAAVNNQVVASNISSNITALNARMDKVQAGNKGPVSSGDEDMDAKFGAWISPFVGNATQKMCNSISGYKSDTTGGTIGFDGFVSDDLVLGLAYTRADTDIKLKNNKTGDKNKVESNIYSLYGLYSVPYENLFVEAIASYSDNKIRSKSRRVIATTLETVGYQTANGKYKSESYTGQLMAGYTYMMSENINLTPLAGLRYSTIKDKSYKETGTTYQNLTVKGKNYNTFDGLLGAKVSSNINVNEIVLTPELYAMVDYAFKNKVSAIDARLQGMTAPLPTNSFKQSKTSFDVGVGVTAKHKMMEYGINYDTNIGSKYFAQQGSVKVRVNF
UniProt ID: Q52657
Variant: R -> H at position 76-76
Variant annotation: in strain: Indian tick typhus
Protein function: Elicits protective immunity.
Reference sequence:
MANISPKLFQKAIQQGLKAALFTTSTAAIMLSSSGALGIAVSGVIATNNNAAFSDNVGNNWNEITAAGVANGTPARGPQNNWAFTYGGDYTITADVADHIITAINVADTTPIGLNIAQNTVVGSIVTGGNLLPVTITAGKSLTLNGNNADAANHGFGAPADNYTGLGNIALGGANAALIIQSAAPAKITLAGNINGGGIITVKTDAAINGTIGNTNALATVNVGAGIATLEGAIIKATTTKLTNAASVLTLTNVNAVLTGAIDNTTGVDNVGVLNLNGALSQVTGNIGNTNALATISVGAGKATLGGAVIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGNSTVTGNIGNTNALATVNVGAGIATLEGAVIKATTTKLTNAASVLTLTNVNAVLTGAIDNTTGVDNVGVLNLNGALSQVTGNIGNTNALATISVGAGKATLGGAVIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIATFTGDSTVTGNIGNTNALATVNVGAGLLRVQGGVVKSNTINLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATVNVGAGVTLQAGGSLDANNIDFGARSTLEFNGPLDGGGNAIPYYFKGAIANGNNAILNVNTKLLTAYHLTIGTVAEINIGAGNLFAIDASAGDVTILNAQDIHFRALDSALVLSNLTGVGVNNILLAADLVAPGVDEGTVVFDGGVNGLNIGSNVAGAARNIGDVGGNKFNTLLIYNAVTITDDVNLEGIQNVLINNNADFTSSTAFNAGTIQINDATYTIDANNGNLNIPAGNIKFAHADAQLILQNSSGNDRTITLGANIDPDNDDEGIVILNSVTAGKKLTIAGGKTFGGAHKLQDIVFKGEGDFGTAGTTFNTTNIVLDITGQLELGATTANVVLFKDAVQLTQTGNIGGFLDFNAKNGTVTLNNNVNVAGTVKNTGGTNNGTLIVLGASNLNRVNGIAMLKVGAGNVTIAKGGNVKIGEIQGTGTNTLTLPAHFKLTGSINKTGGQALKLNFMNGGSVSGVVGTAANSVGDITTAGATSFASSVNAKGTATLGGTTSFAHTFTNTGAVTLAKGSITSFAKNVTATSFVANSATINFGNSLAFNSNITGSGTTLTLGANQVTYTGTGSFTDTLTLNTTFDGAAKSGGNILIKSGSTLDLSGVSNLALVVTATNFDMNNISPDTKYTVISAETAGGLKPTPKENVKITINNDNRFVDFTFDASTLTLFAEDIAAGVIDEDFAPGGPLANIPNAANIKKSLELMEDAPNGSDARQAFNNFGLMTPLQEADATTHLMQDVVKPSDTIAAVNNQVVASNISSNITALNARMDKVQAGNKGPVSSGDEDMDAKFGAWISPFVGNATQKMCNSISGYKSDTTGGTIGFDGFVSDDLVLGLAYTRADTDIKLKNNKTGDKNKVESNIYSLYGLYSVPYENLFVEAIASYSDNKIRSKSRRVIATTLETVGYQTANGKYKSESYTGQLMAGYTYMMSENINLTPLAGLRYSTIKDKSYKETGTTYQNLTVKGKNYNTFDGLLGAKVSSNINVNEIVLTPELYAMVDYAFKNKVSAIDARLQGMTAPLPTNSFKQSKTSFDVGVGVTAKHKMMEYGINYDTNIGSKYFAQQGSVKVRVNF
UniProt ID: Q52657
Variant: VT -> II at position 953-954
Variant annotation: in strain: Indian tick typhus
Protein function: Elicits protective immunity.
Reference sequence:
MANISPKLFQKAIQQGLKAALFTTSTAAIMLSSSGALGIAVSGVIATNNNAAFSDNVGNNWNEITAAGVANGTPARGPQNNWAFTYGGDYTITADVADHIITAINVADTTPIGLNIAQNTVVGSIVTGGNLLPVTITAGKSLTLNGNNADAANHGFGAPADNYTGLGNIALGGANAALIIQSAAPAKITLAGNINGGGIITVKTDAAINGTIGNTNALATVNVGAGIATLEGAIIKATTTKLTNAASVLTLTNVNAVLTGAIDNTTGVDNVGVLNLNGALSQVTGNIGNTNALATISVGAGKATLGGAVIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGNSTVTGNIGNTNALATVNVGAGIATLEGAVIKATTTKLTNAASVLTLTNVNAVLTGAIDNTTGVDNVGVLNLNGALSQVTGNIGNTNALATISVGAGKATLGGAVIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIATFTGDSTVTGNIGNTNALATVNVGAGLLRVQGGVVKSNTINLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATVNVGAGVTLQAGGSLDANNIDFGARSTLEFNGPLDGGGNAIPYYFKGAIANGNNAILNVNTKLLTAYHLTIGTVAEINIGAGNLFAIDASAGDVTILNAQDIHFRALDSALVLSNLTGVGVNNILLAADLVAPGVDEGTVVFDGGVNGLNIGSNVAGAARNIGDVGGNKFNTLLIYNAVTITDDVNLEGIQNVLINNNADFTSSTAFNAGTIQINDATYTIDANNGNLNIPAGNIKFAHADAQLILQNSSGNDRTITLGANIDPDNDDEGIVILNSVTAGKKLTIAGGKTFGGAHKLQDIVFKGEGDFGTAGTTFNTTNIVLDITGQLELGATTANVVLFKDAVQLTQTGNIGGFLDFNAKNGTVTLNNNVNVAGTVKNTGGTNNGTLIVLGASNLNRVNGIAMLKVGAGNVTIAKGGNVKIGEIQGTGTNTLTLPAHFKLTGSINKTGGQALKLNFMNGGSVSGVVGTAANSVGDITTAGATSFASSVNAKGTATLGGTTSFAHTFTNTGAVTLAKGSITSFAKNVTATSFVANSATINFGNSLAFNSNITGSGTTLTLGANQVTYTGTGSFTDTLTLNTTFDGAAKSGGNILIKSGSTLDLSGVSNLALVVTATNFDMNNISPDTKYTVISAETAGGLKPTPKENVKITINNDNRFVDFTFDASTLTLFAEDIAAGVIDEDFAPGGPLANIPNAANIKKSLELMEDAPNGSDARQAFNNFGLMTPLQEADATTHLMQDVVKPSDTIAAVNNQVVASNISSNITALNARMDKVQAGNKGPVSSGDEDMDAKFGAWISPFVGNATQKMCNSISGYKSDTTGGTIGFDGFVSDDLVLGLAYTRADTDIKLKNNKTGDKNKVESNIYSLYGLYSVPYENLFVEAIASYSDNKIRSKSRRVIATTLETVGYQTANGKYKSESYTGQLMAGYTYMMSENINLTPLAGLRYSTIKDKSYKETGTTYQNLTVKGKNYNTFDGLLGAKVSSNINVNEIVLTPELYAMVDYAFKNKVSAIDARLQGMTAPLPTNSFKQSKTSFDVGVGVTAKHKMMEYGINYDTNIGSKYFAQQGSVKVRVNF
UniProt ID: Q52657
Variant: D -> A at position 1245-1245
Variant annotation: in strain: Indian tick typhus, M1 and Moroccan
Protein function: Elicits protective immunity.
Reference sequence:
MANISPKLFQKAIQQGLKAALFTTSTAAIMLSSSGALGIAVSGVIATNNNAAFSDNVGNNWNEITAAGVANGTPARGPQNNWAFTYGGDYTITADVADHIITAINVADTTPIGLNIAQNTVVGSIVTGGNLLPVTITAGKSLTLNGNNADAANHGFGAPADNYTGLGNIALGGANAALIIQSAAPAKITLAGNINGGGIITVKTDAAINGTIGNTNALATVNVGAGIATLEGAIIKATTTKLTNAASVLTLTNVNAVLTGAIDNTTGVDNVGVLNLNGALSQVTGNIGNTNALATISVGAGKATLGGAVIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGNSTVTGNIGNTNALATVNVGAGIATLEGAVIKATTTKLTNAASVLTLTNVNAVLTGAIDNTTGVDNVGVLNLNGALSQVTGNIGNTNALATISVGAGKATLGGAVIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIATFTGDSTVTGNIGNTNALATVNVGAGLLRVQGGVVKSNTINLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATVNVGAGVTLQAGGSLDANNIDFGARSTLEFNGPLDGGGNAIPYYFKGAIANGNNAILNVNTKLLTAYHLTIGTVAEINIGAGNLFAIDASAGDVTILNAQDIHFRALDSALVLSNLTGVGVNNILLAADLVAPGVDEGTVVFDGGVNGLNIGSNVAGAARNIGDVGGNKFNTLLIYNAVTITDDVNLEGIQNVLINNNADFTSSTAFNAGTIQINDATYTIDANNGNLNIPAGNIKFAHADAQLILQNSSGNDRTITLGANIDPDNDDEGIVILNSVTAGKKLTIAGGKTFGGAHKLQDIVFKGEGDFGTAGTTFNTTNIVLDITGQLELGATTANVVLFKDAVQLTQTGNIGGFLDFNAKNGTVTLNNNVNVAGTVKNTGGTNNGTLIVLGASNLNRVNGIAMLKVGAGNVTIAKGGNVKIGEIQGTGTNTLTLPAHFKLTGSINKTGGQALKLNFMNGGSVSGVVGTAANSVGDITTAGATSFASSVNAKGTATLGGTTSFAHTFTNTGAVTLAKGSITSFAKNVTATSFVANSATINFGNSLAFNSNITGSGTTLTLGANQVTYTGTGSFTDTLTLNTTFDGAAKSGGNILIKSGSTLDLSGVSNLALVVTATNFDMNNISPDTKYTVISAETAGGLKPTPKENVKITINNDNRFVDFTFDASTLTLFAEDIAAGVIDEDFAPGGPLANIPNAANIKKSLELMEDAPNGSDARQAFNNFGLMTPLQEADATTHLMQDVVKPSDTIAAVNNQVVASNISSNITALNARMDKVQAGNKGPVSSGDEDMDAKFGAWISPFVGNATQKMCNSISGYKSDTTGGTIGFDGFVSDDLVLGLAYTRADTDIKLKNNKTGDKNKVESNIYSLYGLYSVPYENLFVEAIASYSDNKIRSKSRRVIATTLETVGYQTANGKYKSESYTGQLMAGYTYMMSENINLTPLAGLRYSTIKDKSYKETGTTYQNLTVKGKNYNTFDGLLGAKVSSNINVNEIVLTPELYAMVDYAFKNKVSAIDARLQGMTAPLPTNSFKQSKTSFDVGVGVTAKHKMMEYGINYDTNIGSKYFAQQGSVKVRVNF
UniProt ID: Q52657
Variant: N -> H at position 1308-1308
Variant annotation: in strain: Moroccan
Protein function: Elicits protective immunity.
Reference sequence:
MANISPKLFQKAIQQGLKAALFTTSTAAIMLSSSGALGIAVSGVIATNNNAAFSDNVGNNWNEITAAGVANGTPARGPQNNWAFTYGGDYTITADVADHIITAINVADTTPIGLNIAQNTVVGSIVTGGNLLPVTITAGKSLTLNGNNADAANHGFGAPADNYTGLGNIALGGANAALIIQSAAPAKITLAGNINGGGIITVKTDAAINGTIGNTNALATVNVGAGIATLEGAIIKATTTKLTNAASVLTLTNVNAVLTGAIDNTTGVDNVGVLNLNGALSQVTGNIGNTNALATISVGAGKATLGGAVIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGNSTVTGNIGNTNALATVNVGAGIATLEGAVIKATTTKLTNAASVLTLTNVNAVLTGAIDNTTGVDNVGVLNLNGALSQVTGNIGNTNALATISVGAGKATLGGAVIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIATFTGDSTVTGNIGNTNALATVNVGAGLLRVQGGVVKSNTINLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATVNVGAGVTLQAGGSLDANNIDFGARSTLEFNGPLDGGGNAIPYYFKGAIANGNNAILNVNTKLLTAYHLTIGTVAEINIGAGNLFAIDASAGDVTILNAQDIHFRALDSALVLSNLTGVGVNNILLAADLVAPGVDEGTVVFDGGVNGLNIGSNVAGAARNIGDVGGNKFNTLLIYNAVTITDDVNLEGIQNVLINNNADFTSSTAFNAGTIQINDATYTIDANNGNLNIPAGNIKFAHADAQLILQNSSGNDRTITLGANIDPDNDDEGIVILNSVTAGKKLTIAGGKTFGGAHKLQDIVFKGEGDFGTAGTTFNTTNIVLDITGQLELGATTANVVLFKDAVQLTQTGNIGGFLDFNAKNGTVTLNNNVNVAGTVKNTGGTNNGTLIVLGASNLNRVNGIAMLKVGAGNVTIAKGGNVKIGEIQGTGTNTLTLPAHFKLTGSINKTGGQALKLNFMNGGSVSGVVGTAANSVGDITTAGATSFASSVNAKGTATLGGTTSFAHTFTNTGAVTLAKGSITSFAKNVTATSFVANSATINFGNSLAFNSNITGSGTTLTLGANQVTYTGTGSFTDTLTLNTTFDGAAKSGGNILIKSGSTLDLSGVSNLALVVTATNFDMNNISPDTKYTVISAETAGGLKPTPKENVKITINNDNRFVDFTFDASTLTLFAEDIAAGVIDEDFAPGGPLANIPNAANIKKSLELMEDAPNGSDARQAFNNFGLMTPLQEADATTHLMQDVVKPSDTIAAVNNQVVASNISSNITALNARMDKVQAGNKGPVSSGDEDMDAKFGAWISPFVGNATQKMCNSISGYKSDTTGGTIGFDGFVSDDLVLGLAYTRADTDIKLKNNKTGDKNKVESNIYSLYGLYSVPYENLFVEAIASYSDNKIRSKSRRVIATTLETVGYQTANGKYKSESYTGQLMAGYTYMMSENINLTPLAGLRYSTIKDKSYKETGTTYQNLTVKGKNYNTFDGLLGAKVSSNINVNEIVLTPELYAMVDYAFKNKVSAIDARLQGMTAPLPTNSFKQSKTSFDVGVGVTAKHKMMEYGINYDTNIGSKYFAQQGSVKVRVNF
UniProt ID: Q52657
Variant: M -> I at position 1877-1877
Variant annotation: in strain: Indian tick typhus
Protein function: Elicits protective immunity.
Reference sequence:
MANISPKLFQKAIQQGLKAALFTTSTAAIMLSSSGALGIAVSGVIATNNNAAFSDNVGNNWNEITAAGVANGTPARGPQNNWAFTYGGDYTITADVADHIITAINVADTTPIGLNIAQNTVVGSIVTGGNLLPVTITAGKSLTLNGNNADAANHGFGAPADNYTGLGNIALGGANAALIIQSAAPAKITLAGNINGGGIITVKTDAAINGTIGNTNALATVNVGAGIATLEGAIIKATTTKLTNAASVLTLTNVNAVLTGAIDNTTGVDNVGVLNLNGALSQVTGNIGNTNALATISVGAGKATLGGAVIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGNSTVTGNIGNTNALATVNVGAGIATLEGAVIKATTTKLTNAASVLTLTNVNAVLTGAIDNTTGVDNVGVLNLNGALSQVTGNIGNTNALATISVGAGKATLGGAVIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIATFTGDSTVTGNIGNTNALATVNVGAGLLRVQGGVVKSNTINLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATISVGAGKATLGGAIIKATTTKLTDNASAVTFTNPVVVTGAIDNTGNANNGIVTFTGDSTVTGNIGNTNALATVNVGAGVTLQAGGSLDANNIDFGARSTLEFNGPLDGGGNAIPYYFKGAIANGNNAILNVNTKLLTAYHLTIGTVAEINIGAGNLFAIDASAGDVTILNAQDIHFRALDSALVLSNLTGVGVNNILLAADLVAPGVDEGTVVFDGGVNGLNIGSNVAGAARNIGDVGGNKFNTLLIYNAVTITDDVNLEGIQNVLINNNADFTSSTAFNAGTIQINDATYTIDANNGNLNIPAGNIKFAHADAQLILQNSSGNDRTITLGANIDPDNDDEGIVILNSVTAGKKLTIAGGKTFGGAHKLQDIVFKGEGDFGTAGTTFNTTNIVLDITGQLELGATTANVVLFKDAVQLTQTGNIGGFLDFNAKNGTVTLNNNVNVAGTVKNTGGTNNGTLIVLGASNLNRVNGIAMLKVGAGNVTIAKGGNVKIGEIQGTGTNTLTLPAHFKLTGSINKTGGQALKLNFMNGGSVSGVVGTAANSVGDITTAGATSFASSVNAKGTATLGGTTSFAHTFTNTGAVTLAKGSITSFAKNVTATSFVANSATINFGNSLAFNSNITGSGTTLTLGANQVTYTGTGSFTDTLTLNTTFDGAAKSGGNILIKSGSTLDLSGVSNLALVVTATNFDMNNISPDTKYTVISAETAGGLKPTPKENVKITINNDNRFVDFTFDASTLTLFAEDIAAGVIDEDFAPGGPLANIPNAANIKKSLELMEDAPNGSDARQAFNNFGLMTPLQEADATTHLMQDVVKPSDTIAAVNNQVVASNISSNITALNARMDKVQAGNKGPVSSGDEDMDAKFGAWISPFVGNATQKMCNSISGYKSDTTGGTIGFDGFVSDDLVLGLAYTRADTDIKLKNNKTGDKNKVESNIYSLYGLYSVPYENLFVEAIASYSDNKIRSKSRRVIATTLETVGYQTANGKYKSESYTGQLMAGYTYMMSENINLTPLAGLRYSTIKDKSYKETGTTYQNLTVKGKNYNTFDGLLGAKVSSNINVNEIVLTPELYAMVDYAFKNKVSAIDARLQGMTAPLPTNSFKQSKTSFDVGVGVTAKHKMMEYGINYDTNIGSKYFAQQGSVKVRVNF
UniProt ID: Q52698
Variant: H -> D at position 62-62
Variant annotation: in strain: DSM 938
Protein function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs. Complements an E.coli disruption mutant, but the E.coli enzyme does not cleave R.capsulatus rRNA precursor, showing substrate recognition is different. Probably also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Probably processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
Reference sequence:
MKVAADLSAFMDRLGHRFTTPEHLVRALTHSSLGSATRPDNQRLEFLGDRVLGLSMAEALFHADGRASEGQLAPRFNALVRKETCAAVARDIDLGAVLKLGRSEMMSGGRRKDALLGDAMEAVIAAVYLDAGFEVARALVLRLWAARIQSVDNDARDPKTALQEWAQARGLPPPRYETLGRDGPDHAPQFRIAVVLASGETEEAQAGSKRNAEQAAAKALLERLERGA
UniProt ID: Q52LW3
Variant: S -> C at position 552-552
Variant annotation: in a breast cancer sample; somatic mutation
Protein function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.
Reference sequence:
MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLLYLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHGLVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQFV
UniProt ID: Q52LW3
Variant: P -> L at position 1192-1192
Variant annotation: in dbSNP:rs11165091
Protein function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.
Reference sequence:
MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLLYLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHGLVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQFV
UniProt ID: Q52LW3
Variant: G -> D at position 1255-1255
Variant annotation: in dbSNP:rs1999272
Protein function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.
Reference sequence:
MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLLYLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHGLVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQFV
UniProt ID: Q52M58
Variant: R -> W at position 3-3
Variant annotation: in dbSNP:rs17097718
Protein function: May play a role in the flagellum biology.
Reference sequence:
MHRKEPGARLEATRGAARPHKQGTKPMITRPSVSQLGEGKCPSSQHLQSLRHNKQHALTLTKARCCGECSTCFCTEEKSECQRHEETSPGSCNHQIMSASTISAFCATPRFKQLFKGTVEQMSQM
UniProt ID: Q52M58
Variant: V -> A at position 33-33
Variant annotation: in dbSNP:rs4905757
Protein function: May play a role in the flagellum biology.
Reference sequence:
MHRKEPGARLEATRGAARPHKQGTKPMITRPSVSQLGEGKCPSSQHLQSLRHNKQHALTLTKARCCGECSTCFCTEEKSECQRHEETSPGSCNHQIMSASTISAFCATPRFKQLFKGTVEQMSQM
UniProt ID: Q52WX2
Variant: R -> H at position 12-12
Variant annotation: in dbSNP:rs35448675
Protein function: May be involved in signal-transduction pathways related to the control of brain development.
Reference sequence:
MSVGCPEPEPPRSLTCCGPGTAPGPGAGVPLLTEDMQALTLRTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRRRPSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESGSGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEPGLAPQGPPGRTDGRADKSKGQVVLATAIEICV