sujigwak/NVAR huggingface dataset:
UniProt ID: P33261
Variant: R -> W at position 433-433
Variant annotation: in allele CYP2C19*5A and allele CYP2C19*5B; loss of activity; dbSNP:rs56337013
Effect: loss
Target: activity
Protein function: A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position . Catalyzes the epoxidation of double bonds of PUFA . Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol . Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position .
Reference sequence:
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV
UniProt ID: P33261
Variant: R -> C at position 442-442
Variant annotation: in allele CYP2C19*16; lowered catalytic activity; dbSNP:rs192154563
Protein function: A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) . Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates PUFA specifically at the omega-1 position . Catalyzes the epoxidation of double bonds of PUFA . Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol . Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Hydroxylates fenbendazole at the 4' position .
Reference sequence:
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV
UniProt ID: P33269
Variant: E -> D at position 170-170
Variant annotation: in strain: CAM-2, CAM-3, CAM-8, CAM-12, CAM-41, CAM-44, CAM-48 and Berkeley
Protein function: Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Reference sequence:
MFLVIGAILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMETYSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGESGFSLYDWINLCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNSFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFKVRERVY
UniProt ID: P33269
Variant: S -> I at position 426-426
Variant annotation: in strain: CAM-8, CAM-44, CAM-48 and Berkeley
Protein function: Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Reference sequence:
MFLVIGAILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKKIFEFMETYSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGESGFSLYDWINLCTMDTICETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNSFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFKVRERVY
UniProt ID: P33333
Variant: Q -> L at position 44-44
Variant annotation: in allele suppressor SLC1-1
Protein function: Acyltransferase that catalyzes the sn-2-specific, acyl-CoA-dependent acylation of lysophosphatidic acid (LPA) to phosphatidic acid (PA) in lipid particles . Together with ALE1, plays a central role in PA biosynthesis. PA is the intermediate, from which all glycerophospholipids are synthesized . Can also acylate lysophosphoinositol (LPI) and lysophosphoserine (LPS) . The fatty acyl substrates include 18:1-acyl-CoA, 14:0-acyl-CoA, 12:0-acyl-CoA and 10:0-acyl-CoA .
Reference sequence:
MSVIGRFLYYLRSVLVVLALAGCGFYGVIASILCTLIGKQHLAQWITARCFYHVMKLMLGLDVKVVGEENLAKKPYIMIANHQSTLDIFMLGRIFPPGCTVTAKKSLKYVPFLGWFMALSGTYFLDRSKRQEAIDTLNKGLENVKKNKRALWVFPEGTRSYTSELTMLPFKKGAFHLAQQGKIPIVPVVVSNTSTLVSPKYGVFNRGCMIVRILKPISTENLTKDKIGEFAEKVRDQMVDTLKEIGYSPAINDTTLPPQAIEYAALQHDKKVNKKIKNEPVPSVSISNDVNTHNEGSSVKKMH
UniProt ID: P33339
Variant: I -> T at position 280-280
Variant annotation: in strain: SK1
Protein function: TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. TFC4 is the TFIIIB-assembling subunit of TFIIIC and essential for viability.
Reference sequence:
MAAGKLKKEQQNQSAERESADTGKVNDEDEEHLYGNIDDYKHLIQDEEYDDEDVPHDLQLSEDEYNSERDSSLLAEFSDYGEISEDDEEDFMNAIREASNFKVKKKKKNDKGKSYGRQRKERVLDPEVAQLLSQANEAFVRNDLQVAERLFNEVIKKDARNFAAYETLGDIYQLQGRLNDCCNSWFLAAHLNASDWEFWKIVAILSADLDHVRQAIYCFSRVISLNPMEWESIYRRSMLYKKTGQLARALDGFQRLYMYNPYDANILRELAILYVDYDRIEDSIELYMKVFNANVERREAILAALENALDSSDEESAAEGEDADEKEPLEQDEDRQMFPDINWKKIDAKYKCIPFDWSSLNILAELFLKLAVSEVDGIKTIKKCARWIQRRESQTFWDHVPDDSEFDNRRFKNSTFDSLLAAEKEKSYNIPIDIRVRLGLLRLNTDNLVEALNHFQCLYDETFSDVADLYFEAATALTRAEKYKEAIDFFTPLLSLEEWRTTDVFKPLARCYKEIESYETAKEFYELAIKSEPDDLDIRVSLAEVYYRLNDPETFKHMLVDVVEMRKHQVDETLHRISNEKSSNDTSDISSKPLLEDSKFRTFRKKKRTPYDAERERIERERRITAKVVDKYEKMKKFELNSGLNEAKQASIWINTVSELVDIFSSVKNFFMKSRSRKFVGILRRTKKFNTELDFQIERLSKLAEGDSVFEGPLMEERVTLTSATELRGLSYEQWFELFMELSLVIAKYQSVEDGLSVVETAQEVNVFFQDPERVKMMKFVKLAIVLQMDDEEELAENLRGLLNQFQFNRKVLQVFMYSLCRGPSSLNILSSTIQQKFFLRQLKAFDSCRYNTEVNGQASITNKEVYNPNKKSSPYLYYIYAVLLYSSRGFLSALQYLTRLEEDIPDDPMVNLLMGLSHIHRAMQRLTAQRHFQIFHGLRYLYRYHKIRKSLYTDLEKQEADYNLGRAFHLIGLVSIAIEYYNRVLENYDDGKLKKHAAYNSIIIYQQSGNVELADHLMEKYLSI
UniProt ID: P33339
Variant: M -> V at position 635-635
Variant annotation: in strain: SK1
Protein function: TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. TFC4 is the TFIIIB-assembling subunit of TFIIIC and essential for viability.
Reference sequence:
MAAGKLKKEQQNQSAERESADTGKVNDEDEEHLYGNIDDYKHLIQDEEYDDEDVPHDLQLSEDEYNSERDSSLLAEFSDYGEISEDDEEDFMNAIREASNFKVKKKKKNDKGKSYGRQRKERVLDPEVAQLLSQANEAFVRNDLQVAERLFNEVIKKDARNFAAYETLGDIYQLQGRLNDCCNSWFLAAHLNASDWEFWKIVAILSADLDHVRQAIYCFSRVISLNPMEWESIYRRSMLYKKTGQLARALDGFQRLYMYNPYDANILRELAILYVDYDRIEDSIELYMKVFNANVERREAILAALENALDSSDEESAAEGEDADEKEPLEQDEDRQMFPDINWKKIDAKYKCIPFDWSSLNILAELFLKLAVSEVDGIKTIKKCARWIQRRESQTFWDHVPDDSEFDNRRFKNSTFDSLLAAEKEKSYNIPIDIRVRLGLLRLNTDNLVEALNHFQCLYDETFSDVADLYFEAATALTRAEKYKEAIDFFTPLLSLEEWRTTDVFKPLARCYKEIESYETAKEFYELAIKSEPDDLDIRVSLAEVYYRLNDPETFKHMLVDVVEMRKHQVDETLHRISNEKSSNDTSDISSKPLLEDSKFRTFRKKKRTPYDAERERIERERRITAKVVDKYEKMKKFELNSGLNEAKQASIWINTVSELVDIFSSVKNFFMKSRSRKFVGILRRTKKFNTELDFQIERLSKLAEGDSVFEGPLMEERVTLTSATELRGLSYEQWFELFMELSLVIAKYQSVEDGLSVVETAQEVNVFFQDPERVKMMKFVKLAIVLQMDDEEELAENLRGLLNQFQFNRKVLQVFMYSLCRGPSSLNILSSTIQQKFFLRQLKAFDSCRYNTEVNGQASITNKEVYNPNKKSSPYLYYIYAVLLYSSRGFLSALQYLTRLEEDIPDDPMVNLLMGLSHIHRAMQRLTAQRHFQIFHGLRYLYRYHKIRKSLYTDLEKQEADYNLGRAFHLIGLVSIAIEYYNRVLENYDDGKLKKHAAYNSIIIYQQSGNVELADHLMEKYLSI
UniProt ID: P33339
Variant: I -> V at position 1025-1025
Variant annotation: in strain: SK1
Protein function: TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. TFC4 is the TFIIIB-assembling subunit of TFIIIC and essential for viability.
Reference sequence:
MAAGKLKKEQQNQSAERESADTGKVNDEDEEHLYGNIDDYKHLIQDEEYDDEDVPHDLQLSEDEYNSERDSSLLAEFSDYGEISEDDEEDFMNAIREASNFKVKKKKKNDKGKSYGRQRKERVLDPEVAQLLSQANEAFVRNDLQVAERLFNEVIKKDARNFAAYETLGDIYQLQGRLNDCCNSWFLAAHLNASDWEFWKIVAILSADLDHVRQAIYCFSRVISLNPMEWESIYRRSMLYKKTGQLARALDGFQRLYMYNPYDANILRELAILYVDYDRIEDSIELYMKVFNANVERREAILAALENALDSSDEESAAEGEDADEKEPLEQDEDRQMFPDINWKKIDAKYKCIPFDWSSLNILAELFLKLAVSEVDGIKTIKKCARWIQRRESQTFWDHVPDDSEFDNRRFKNSTFDSLLAAEKEKSYNIPIDIRVRLGLLRLNTDNLVEALNHFQCLYDETFSDVADLYFEAATALTRAEKYKEAIDFFTPLLSLEEWRTTDVFKPLARCYKEIESYETAKEFYELAIKSEPDDLDIRVSLAEVYYRLNDPETFKHMLVDVVEMRKHQVDETLHRISNEKSSNDTSDISSKPLLEDSKFRTFRKKKRTPYDAERERIERERRITAKVVDKYEKMKKFELNSGLNEAKQASIWINTVSELVDIFSSVKNFFMKSRSRKFVGILRRTKKFNTELDFQIERLSKLAEGDSVFEGPLMEERVTLTSATELRGLSYEQWFELFMELSLVIAKYQSVEDGLSVVETAQEVNVFFQDPERVKMMKFVKLAIVLQMDDEEELAENLRGLLNQFQFNRKVLQVFMYSLCRGPSSLNILSSTIQQKFFLRQLKAFDSCRYNTEVNGQASITNKEVYNPNKKSSPYLYYIYAVLLYSSRGFLSALQYLTRLEEDIPDDPMVNLLMGLSHIHRAMQRLTAQRHFQIFHGLRYLYRYHKIRKSLYTDLEKQEADYNLGRAFHLIGLVSIAIEYYNRVLENYDDGKLKKHAAYNSIIIYQQSGNVELADHLMEKYLSI
UniProt ID: P33439
Variant: S -> R at position 47-47
Protein function: Stimulates the secretion of gonadotropins.
Reference sequence:
MGIKRALWWMVVCVVVLQVSAQHWSHGLNPGGKRAVMQESAEEIPRSSGYLCDYVAVSPGNKPFRLKDLLTPVAGREIEE
UniProt ID: P33439
Variant: G -> R at position 60-60
Protein function: Stimulates the secretion of gonadotropins.
Reference sequence:
MGIKRALWWMVVCVVVLQVSAQHWSHGLNPGGKRAVMQESAEEIPRSSGYLCDYVAVSPGNKPFRLKDLLTPVAGREIEE
UniProt ID: P33522
Variant: N -> M at position 110-110
Protein function: This is a seed storage protein.
Reference sequence:
MGPTSLLSFFFTFLTLFHGFTAQQWPNECQLDQLNALEPSQIIKSEGGRIEVWDHHAPQLRCSGFAFERFVIEPQGLYLPTFLNAGKLTFVVHGHALMGKVTPGCAETFNDSPVFGQGQGQEQGQGQGQGQGQGFRDMHQKVEHLRSGDTIATPPGVAQWFYNNGNEPLILVAAADIANNLNQLDRNLRPFLLAGNNPQGQQWLQGRQQQKQNNIFNGFAPQILAQAFKISVETAQKLQNQQVNRGNIVKVQGQFGVIRPPLRQGQGGQQPQEEGNGLEETLCTMRCTENLDDPSSADVYKPSLGYISTLNSYNLPILRFLRLSALRGSIHNNAMVLPQWNVNANAALYVTKGKAHIQNVNDNGQRVFDQEISKGQLLVVPQGFAVVKRATSQQFQWIEFKSNDNAQINTLAGRTSVMRGLPLEVISNGYQISPQEARSVKFSTLETTLTQSSGPMGYGMPRVEA
UniProt ID: P33522
Variant: S -> H at position 147-147
Protein function: This is a seed storage protein.
Reference sequence:
MGPTSLLSFFFTFLTLFHGFTAQQWPNECQLDQLNALEPSQIIKSEGGRIEVWDHHAPQLRCSGFAFERFVIEPQGLYLPTFLNAGKLTFVVHGHALMGKVTPGCAETFNDSPVFGQGQGQEQGQGQGQGQGQGFRDMHQKVEHLRSGDTIATPPGVAQWFYNNGNEPLILVAAADIANNLNQLDRNLRPFLLAGNNPQGQQWLQGRQQQKQNNIFNGFAPQILAQAFKISVETAQKLQNQQVNRGNIVKVQGQFGVIRPPLRQGQGGQQPQEEGNGLEETLCTMRCTENLDDPSSADVYKPSLGYISTLNSYNLPILRFLRLSALRGSIHNNAMVLPQWNVNANAALYVTKGKAHIQNVNDNGQRVFDQEISKGQLLVVPQGFAVVKRATSQQFQWIEFKSNDNAQINTLAGRTSVMRGLPLEVISNGYQISPQEARSVKFSTLETTLTQSSGPMGYGMPRVEA
UniProt ID: P33522
Variant: N -> M at position 359-359
Protein function: This is a seed storage protein.
Reference sequence:
MGPTSLLSFFFTFLTLFHGFTAQQWPNECQLDQLNALEPSQIIKSEGGRIEVWDHHAPQLRCSGFAFERFVIEPQGLYLPTFLNAGKLTFVVHGHALMGKVTPGCAETFNDSPVFGQGQGQEQGQGQGQGQGQGFRDMHQKVEHLRSGDTIATPPGVAQWFYNNGNEPLILVAAADIANNLNQLDRNLRPFLLAGNNPQGQQWLQGRQQQKQNNIFNGFAPQILAQAFKISVETAQKLQNQQVNRGNIVKVQGQFGVIRPPLRQGQGGQQPQEEGNGLEETLCTMRCTENLDDPSSADVYKPSLGYISTLNSYNLPILRFLRLSALRGSIHNNAMVLPQWNVNANAALYVTKGKAHIQNVNDNGQRVFDQEISKGQLLVVPQGFAVVKRATSQQFQWIEFKSNDNAQINTLAGRTSVMRGLPLEVISNGYQISPQEARSVKFSTLETTLTQSSGPMGYGMPRVEA
UniProt ID: P33522
Variant: K -> Q at position 374-374
Protein function: This is a seed storage protein.
Reference sequence:
MGPTSLLSFFFTFLTLFHGFTAQQWPNECQLDQLNALEPSQIIKSEGGRIEVWDHHAPQLRCSGFAFERFVIEPQGLYLPTFLNAGKLTFVVHGHALMGKVTPGCAETFNDSPVFGQGQGQEQGQGQGQGQGQGFRDMHQKVEHLRSGDTIATPPGVAQWFYNNGNEPLILVAAADIANNLNQLDRNLRPFLLAGNNPQGQQWLQGRQQQKQNNIFNGFAPQILAQAFKISVETAQKLQNQQVNRGNIVKVQGQFGVIRPPLRQGQGGQQPQEEGNGLEETLCTMRCTENLDDPSSADVYKPSLGYISTLNSYNLPILRFLRLSALRGSIHNNAMVLPQWNVNANAALYVTKGKAHIQNVNDNGQRVFDQEISKGQLLVVPQGFAVVKRATSQQFQWIEFKSNDNAQINTLAGRTSVMRGLPLEVISNGYQISPQEARSVKFSTLETTLTQSSGPMGYGMPRVEA
UniProt ID: P33546
Variant: S -> I at position 2-2
Variant annotation: in plasmid pCP301 and plasmid pINV_F6_M1382
Protein function: Virulence-associated N-epsilon-fatty acyltransferase that mediates lysine-stearoylation of host Rho GTPase proteins, thereby disrupting the host actin cytoskeleton . Required at the post-invasion stage of Shigella pathogenicity .
Reference sequence:
MSLKISNFIDASNTKGPIRVEDTEHGPILIAQKFNLKDLFFRTLSTINAKINSQILNEQLKNYRLENQKSLLLFLNTLASEKSAESAFAAYEAAKNSIQHSFTGRDIKLMLNTAERFHGIGTAKNLERHLVFRCWGNRGITHLGHTSISIKNNLLQEPTHTYLSWYPGGNVTKDTEINYLFEKRSGYSVDTYKQDKLNMISEQTAERLDAGQEVRNLLNSKQDQNNNKKIFFPRANQKKDPYGYWGVSADKVYIPLSGDNKTKDGKISHNLFGLDETNMSKFICKKKADAFRQLANYKLISKSENCAGMALNVLKAGNSEIYFPLPDVKLVATPNDVYAYANKVRQRIESLNQSYNEIMKYIESDFDLSRLTQLRRSYLKSFNKINLIHTPKTFKPLSISLYKHPTENVSSEDFDAVINACHSYLVKSAPSNMTRVLNELKTEATDKKEEIIEKSIKIIDYYNSLKSPDLGTKLYIHDLLQINKLLLNNSHSNI
UniProt ID: P33546
Variant: I -> V at position 30-30
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Virulence-associated N-epsilon-fatty acyltransferase that mediates lysine-stearoylation of host Rho GTPase proteins, thereby disrupting the host actin cytoskeleton . Required at the post-invasion stage of Shigella pathogenicity .
Reference sequence:
MSLKISNFIDASNTKGPIRVEDTEHGPILIAQKFNLKDLFFRTLSTINAKINSQILNEQLKNYRLENQKSLLLFLNTLASEKSAESAFAAYEAAKNSIQHSFTGRDIKLMLNTAERFHGIGTAKNLERHLVFRCWGNRGITHLGHTSISIKNNLLQEPTHTYLSWYPGGNVTKDTEINYLFEKRSGYSVDTYKQDKLNMISEQTAERLDAGQEVRNLLNSKQDQNNNKKIFFPRANQKKDPYGYWGVSADKVYIPLSGDNKTKDGKISHNLFGLDETNMSKFICKKKADAFRQLANYKLISKSENCAGMALNVLKAGNSEIYFPLPDVKLVATPNDVYAYANKVRQRIESLNQSYNEIMKYIESDFDLSRLTQLRRSYLKSFNKINLIHTPKTFKPLSISLYKHPTENVSSEDFDAVINACHSYLVKSAPSNMTRVLNELKTEATDKKEEIIEKSIKIIDYYNSLKSPDLGTKLYIHDLLQINKLLLNNSHSNI
UniProt ID: P33546
Variant: E -> A at position 66-66
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Virulence-associated N-epsilon-fatty acyltransferase that mediates lysine-stearoylation of host Rho GTPase proteins, thereby disrupting the host actin cytoskeleton . Required at the post-invasion stage of Shigella pathogenicity .
Reference sequence:
MSLKISNFIDASNTKGPIRVEDTEHGPILIAQKFNLKDLFFRTLSTINAKINSQILNEQLKNYRLENQKSLLLFLNTLASEKSAESAFAAYEAAKNSIQHSFTGRDIKLMLNTAERFHGIGTAKNLERHLVFRCWGNRGITHLGHTSISIKNNLLQEPTHTYLSWYPGGNVTKDTEINYLFEKRSGYSVDTYKQDKLNMISEQTAERLDAGQEVRNLLNSKQDQNNNKKIFFPRANQKKDPYGYWGVSADKVYIPLSGDNKTKDGKISHNLFGLDETNMSKFICKKKADAFRQLANYKLISKSENCAGMALNVLKAGNSEIYFPLPDVKLVATPNDVYAYANKVRQRIESLNQSYNEIMKYIESDFDLSRLTQLRRSYLKSFNKINLIHTPKTFKPLSISLYKHPTENVSSEDFDAVINACHSYLVKSAPSNMTRVLNELKTEATDKKEEIIEKSIKIIDYYNSLKSPDLGTKLYIHDLLQINKLLLNNSHSNI
UniProt ID: P33546
Variant: N -> K at position 76-76
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Virulence-associated N-epsilon-fatty acyltransferase that mediates lysine-stearoylation of host Rho GTPase proteins, thereby disrupting the host actin cytoskeleton . Required at the post-invasion stage of Shigella pathogenicity .
Reference sequence:
MSLKISNFIDASNTKGPIRVEDTEHGPILIAQKFNLKDLFFRTLSTINAKINSQILNEQLKNYRLENQKSLLLFLNTLASEKSAESAFAAYEAAKNSIQHSFTGRDIKLMLNTAERFHGIGTAKNLERHLVFRCWGNRGITHLGHTSISIKNNLLQEPTHTYLSWYPGGNVTKDTEINYLFEKRSGYSVDTYKQDKLNMISEQTAERLDAGQEVRNLLNSKQDQNNNKKIFFPRANQKKDPYGYWGVSADKVYIPLSGDNKTKDGKISHNLFGLDETNMSKFICKKKADAFRQLANYKLISKSENCAGMALNVLKAGNSEIYFPLPDVKLVATPNDVYAYANKVRQRIESLNQSYNEIMKYIESDFDLSRLTQLRRSYLKSFNKINLIHTPKTFKPLSISLYKHPTENVSSEDFDAVINACHSYLVKSAPSNMTRVLNELKTEATDKKEEIIEKSIKIIDYYNSLKSPDLGTKLYIHDLLQINKLLLNNSHSNI
UniProt ID: P33546
Variant: A -> V at position 94-94
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Virulence-associated N-epsilon-fatty acyltransferase that mediates lysine-stearoylation of host Rho GTPase proteins, thereby disrupting the host actin cytoskeleton . Required at the post-invasion stage of Shigella pathogenicity .
Reference sequence:
MSLKISNFIDASNTKGPIRVEDTEHGPILIAQKFNLKDLFFRTLSTINAKINSQILNEQLKNYRLENQKSLLLFLNTLASEKSAESAFAAYEAAKNSIQHSFTGRDIKLMLNTAERFHGIGTAKNLERHLVFRCWGNRGITHLGHTSISIKNNLLQEPTHTYLSWYPGGNVTKDTEINYLFEKRSGYSVDTYKQDKLNMISEQTAERLDAGQEVRNLLNSKQDQNNNKKIFFPRANQKKDPYGYWGVSADKVYIPLSGDNKTKDGKISHNLFGLDETNMSKFICKKKADAFRQLANYKLISKSENCAGMALNVLKAGNSEIYFPLPDVKLVATPNDVYAYANKVRQRIESLNQSYNEIMKYIESDFDLSRLTQLRRSYLKSFNKINLIHTPKTFKPLSISLYKHPTENVSSEDFDAVINACHSYLVKSAPSNMTRVLNELKTEATDKKEEIIEKSIKIIDYYNSLKSPDLGTKLYIHDLLQINKLLLNNSHSNI
UniProt ID: P33546
Variant: R -> K at position 105-105
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Virulence-associated N-epsilon-fatty acyltransferase that mediates lysine-stearoylation of host Rho GTPase proteins, thereby disrupting the host actin cytoskeleton . Required at the post-invasion stage of Shigella pathogenicity .
Reference sequence:
MSLKISNFIDASNTKGPIRVEDTEHGPILIAQKFNLKDLFFRTLSTINAKINSQILNEQLKNYRLENQKSLLLFLNTLASEKSAESAFAAYEAAKNSIQHSFTGRDIKLMLNTAERFHGIGTAKNLERHLVFRCWGNRGITHLGHTSISIKNNLLQEPTHTYLSWYPGGNVTKDTEINYLFEKRSGYSVDTYKQDKLNMISEQTAERLDAGQEVRNLLNSKQDQNNNKKIFFPRANQKKDPYGYWGVSADKVYIPLSGDNKTKDGKISHNLFGLDETNMSKFICKKKADAFRQLANYKLISKSENCAGMALNVLKAGNSEIYFPLPDVKLVATPNDVYAYANKVRQRIESLNQSYNEIMKYIESDFDLSRLTQLRRSYLKSFNKINLIHTPKTFKPLSISLYKHPTENVSSEDFDAVINACHSYLVKSAPSNMTRVLNELKTEATDKKEEIIEKSIKIIDYYNSLKSPDLGTKLYIHDLLQINKLLLNNSHSNI
UniProt ID: P33546
Variant: R -> A at position 116-116
Variant annotation: in plasmid pWR100
Protein function: Virulence-associated N-epsilon-fatty acyltransferase that mediates lysine-stearoylation of host Rho GTPase proteins, thereby disrupting the host actin cytoskeleton . Required at the post-invasion stage of Shigella pathogenicity .
Reference sequence:
MSLKISNFIDASNTKGPIRVEDTEHGPILIAQKFNLKDLFFRTLSTINAKINSQILNEQLKNYRLENQKSLLLFLNTLASEKSAESAFAAYEAAKNSIQHSFTGRDIKLMLNTAERFHGIGTAKNLERHLVFRCWGNRGITHLGHTSISIKNNLLQEPTHTYLSWYPGGNVTKDTEINYLFEKRSGYSVDTYKQDKLNMISEQTAERLDAGQEVRNLLNSKQDQNNNKKIFFPRANQKKDPYGYWGVSADKVYIPLSGDNKTKDGKISHNLFGLDETNMSKFICKKKADAFRQLANYKLISKSENCAGMALNVLKAGNSEIYFPLPDVKLVATPNDVYAYANKVRQRIESLNQSYNEIMKYIESDFDLSRLTQLRRSYLKSFNKINLIHTPKTFKPLSISLYKHPTENVSSEDFDAVINACHSYLVKSAPSNMTRVLNELKTEATDKKEEIIEKSIKIIDYYNSLKSPDLGTKLYIHDLLQINKLLLNNSHSNI
UniProt ID: P33546
Variant: R -> S at position 116-116
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Virulence-associated N-epsilon-fatty acyltransferase that mediates lysine-stearoylation of host Rho GTPase proteins, thereby disrupting the host actin cytoskeleton . Required at the post-invasion stage of Shigella pathogenicity .
Reference sequence:
MSLKISNFIDASNTKGPIRVEDTEHGPILIAQKFNLKDLFFRTLSTINAKINSQILNEQLKNYRLENQKSLLLFLNTLASEKSAESAFAAYEAAKNSIQHSFTGRDIKLMLNTAERFHGIGTAKNLERHLVFRCWGNRGITHLGHTSISIKNNLLQEPTHTYLSWYPGGNVTKDTEINYLFEKRSGYSVDTYKQDKLNMISEQTAERLDAGQEVRNLLNSKQDQNNNKKIFFPRANQKKDPYGYWGVSADKVYIPLSGDNKTKDGKISHNLFGLDETNMSKFICKKKADAFRQLANYKLISKSENCAGMALNVLKAGNSEIYFPLPDVKLVATPNDVYAYANKVRQRIESLNQSYNEIMKYIESDFDLSRLTQLRRSYLKSFNKINLIHTPKTFKPLSISLYKHPTENVSSEDFDAVINACHSYLVKSAPSNMTRVLNELKTEATDKKEEIIEKSIKIIDYYNSLKSPDLGTKLYIHDLLQINKLLLNNSHSNI
UniProt ID: P33546
Variant: E -> D at position 202-202
Variant annotation: in plasmid pCP301 and plasmid pINV_F6_M1382
Protein function: Virulence-associated N-epsilon-fatty acyltransferase that mediates lysine-stearoylation of host Rho GTPase proteins, thereby disrupting the host actin cytoskeleton . Required at the post-invasion stage of Shigella pathogenicity .
Reference sequence:
MSLKISNFIDASNTKGPIRVEDTEHGPILIAQKFNLKDLFFRTLSTINAKINSQILNEQLKNYRLENQKSLLLFLNTLASEKSAESAFAAYEAAKNSIQHSFTGRDIKLMLNTAERFHGIGTAKNLERHLVFRCWGNRGITHLGHTSISIKNNLLQEPTHTYLSWYPGGNVTKDTEINYLFEKRSGYSVDTYKQDKLNMISEQTAERLDAGQEVRNLLNSKQDQNNNKKIFFPRANQKKDPYGYWGVSADKVYIPLSGDNKTKDGKISHNLFGLDETNMSKFICKKKADAFRQLANYKLISKSENCAGMALNVLKAGNSEIYFPLPDVKLVATPNDVYAYANKVRQRIESLNQSYNEIMKYIESDFDLSRLTQLRRSYLKSFNKINLIHTPKTFKPLSISLYKHPTENVSSEDFDAVINACHSYLVKSAPSNMTRVLNELKTEATDKKEEIIEKSIKIIDYYNSLKSPDLGTKLYIHDLLQINKLLLNNSHSNI
UniProt ID: P33546
Variant: H -> Y at position 269-269
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Virulence-associated N-epsilon-fatty acyltransferase that mediates lysine-stearoylation of host Rho GTPase proteins, thereby disrupting the host actin cytoskeleton . Required at the post-invasion stage of Shigella pathogenicity .
Reference sequence:
MSLKISNFIDASNTKGPIRVEDTEHGPILIAQKFNLKDLFFRTLSTINAKINSQILNEQLKNYRLENQKSLLLFLNTLASEKSAESAFAAYEAAKNSIQHSFTGRDIKLMLNTAERFHGIGTAKNLERHLVFRCWGNRGITHLGHTSISIKNNLLQEPTHTYLSWYPGGNVTKDTEINYLFEKRSGYSVDTYKQDKLNMISEQTAERLDAGQEVRNLLNSKQDQNNNKKIFFPRANQKKDPYGYWGVSADKVYIPLSGDNKTKDGKISHNLFGLDETNMSKFICKKKADAFRQLANYKLISKSENCAGMALNVLKAGNSEIYFPLPDVKLVATPNDVYAYANKVRQRIESLNQSYNEIMKYIESDFDLSRLTQLRRSYLKSFNKINLIHTPKTFKPLSISLYKHPTENVSSEDFDAVINACHSYLVKSAPSNMTRVLNELKTEATDKKEEIIEKSIKIIDYYNSLKSPDLGTKLYIHDLLQINKLLLNNSHSNI
UniProt ID: P33546
Variant: K -> Q at position 285-285
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Virulence-associated N-epsilon-fatty acyltransferase that mediates lysine-stearoylation of host Rho GTPase proteins, thereby disrupting the host actin cytoskeleton . Required at the post-invasion stage of Shigella pathogenicity .
Reference sequence:
MSLKISNFIDASNTKGPIRVEDTEHGPILIAQKFNLKDLFFRTLSTINAKINSQILNEQLKNYRLENQKSLLLFLNTLASEKSAESAFAAYEAAKNSIQHSFTGRDIKLMLNTAERFHGIGTAKNLERHLVFRCWGNRGITHLGHTSISIKNNLLQEPTHTYLSWYPGGNVTKDTEINYLFEKRSGYSVDTYKQDKLNMISEQTAERLDAGQEVRNLLNSKQDQNNNKKIFFPRANQKKDPYGYWGVSADKVYIPLSGDNKTKDGKISHNLFGLDETNMSKFICKKKADAFRQLANYKLISKSENCAGMALNVLKAGNSEIYFPLPDVKLVATPNDVYAYANKVRQRIESLNQSYNEIMKYIESDFDLSRLTQLRRSYLKSFNKINLIHTPKTFKPLSISLYKHPTENVSSEDFDAVINACHSYLVKSAPSNMTRVLNELKTEATDKKEEIIEKSIKIIDYYNSLKSPDLGTKLYIHDLLQINKLLLNNSHSNI
UniProt ID: P33546
Variant: D -> N at position 336-336
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Virulence-associated N-epsilon-fatty acyltransferase that mediates lysine-stearoylation of host Rho GTPase proteins, thereby disrupting the host actin cytoskeleton . Required at the post-invasion stage of Shigella pathogenicity .
Reference sequence:
MSLKISNFIDASNTKGPIRVEDTEHGPILIAQKFNLKDLFFRTLSTINAKINSQILNEQLKNYRLENQKSLLLFLNTLASEKSAESAFAAYEAAKNSIQHSFTGRDIKLMLNTAERFHGIGTAKNLERHLVFRCWGNRGITHLGHTSISIKNNLLQEPTHTYLSWYPGGNVTKDTEINYLFEKRSGYSVDTYKQDKLNMISEQTAERLDAGQEVRNLLNSKQDQNNNKKIFFPRANQKKDPYGYWGVSADKVYIPLSGDNKTKDGKISHNLFGLDETNMSKFICKKKADAFRQLANYKLISKSENCAGMALNVLKAGNSEIYFPLPDVKLVATPNDVYAYANKVRQRIESLNQSYNEIMKYIESDFDLSRLTQLRRSYLKSFNKINLIHTPKTFKPLSISLYKHPTENVSSEDFDAVINACHSYLVKSAPSNMTRVLNELKTEATDKKEEIIEKSIKIIDYYNSLKSPDLGTKLYIHDLLQINKLLLNNSHSNI
UniProt ID: P33546
Variant: T -> S at position 434-434
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Virulence-associated N-epsilon-fatty acyltransferase that mediates lysine-stearoylation of host Rho GTPase proteins, thereby disrupting the host actin cytoskeleton . Required at the post-invasion stage of Shigella pathogenicity .
Reference sequence:
MSLKISNFIDASNTKGPIRVEDTEHGPILIAQKFNLKDLFFRTLSTINAKINSQILNEQLKNYRLENQKSLLLFLNTLASEKSAESAFAAYEAAKNSIQHSFTGRDIKLMLNTAERFHGIGTAKNLERHLVFRCWGNRGITHLGHTSISIKNNLLQEPTHTYLSWYPGGNVTKDTEINYLFEKRSGYSVDTYKQDKLNMISEQTAERLDAGQEVRNLLNSKQDQNNNKKIFFPRANQKKDPYGYWGVSADKVYIPLSGDNKTKDGKISHNLFGLDETNMSKFICKKKADAFRQLANYKLISKSENCAGMALNVLKAGNSEIYFPLPDVKLVATPNDVYAYANKVRQRIESLNQSYNEIMKYIESDFDLSRLTQLRRSYLKSFNKINLIHTPKTFKPLSISLYKHPTENVSSEDFDAVINACHSYLVKSAPSNMTRVLNELKTEATDKKEEIIEKSIKIIDYYNSLKSPDLGTKLYIHDLLQINKLLLNNSHSNI