sujigwak/NVAR huggingface dataset:
UniProt ID: Q9Y6Y1
Variant: S -> T at position 1473-1473
Variant annotation: found in patients with late onset progressive myoclonus epilepsy; uncertain significance; dbSNP:rs776553769
Protein function: Transcriptional activator.
Reference sequence:
MWRAEGKWLPKTSRKSVSQSVFCGTSTYCVLNTVPPIEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGGSVHHKCNSAKHRIISPKVEPRTGGYGSHSEVQHNDVSEGKHEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSESLSMLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNPKQGQTYGGGGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTSFEQQMAKEAYSSSAAAVAASSLTLTAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKPLPVEQNTHSSLSDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYLQPETNGVIRSAGGVPILPGNVVQGLYPVAQPSLGNASNMELSLDHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDGARAPFTQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEVVSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGALGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQNPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQTRQEKLLPTALSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELSPPTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAAPSQVRPREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSGLERTDPATISSTMSWLASYLADADCLPSAAQIRSAYNEPLTPSSNTSLSPVGSPVSEIAFEKPNLPSAADWSEFLSASTSEKVENEFAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLIQKYYRSYKKCGKRRQARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYKRSERIEKGQGT
UniProt ID: Q9Y6Y9
Variant: R -> G at position 56-56
Variant annotation: in dbSNP:rs6472812
Protein function: Binds bacterial lipopolysaccharide (LPS) . Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria . Enhances TLR4-dependent activation of NF-kappa-B . Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS .
Reference sequence:
MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGLLHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFSFKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN
UniProt ID: Q9Y6Y9
Variant: P -> S at position 157-157
Variant annotation: in dbSNP:rs11466004
Protein function: Binds bacterial lipopolysaccharide (LPS) . Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria . Enhances TLR4-dependent activation of NF-kappa-B . Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS .
Reference sequence:
MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGLLHIFYIPRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFSFKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN
UniProt ID: Q9Y6Z7
Variant: C -> W at position 176-176
Variant annotation: in 3MC3; severely decreased secretion; dbSNP:rs773764995
Protein function: Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine . Acts as a chemoattractant, probably involved in the regulation of cell migration .
Reference sequence:
MNGFASLLRRNQFILLVLFLLQIQSLGLDIDSRPTAEVCATHTISPGPKGDDGEKGDPGEEGKHGKVGRMGPKGIKGELGDMGDQGNIGKTGPIGKKGDKGEKGLLGIPGEKGKAGTVCDCGRYRKFVGQLDISIARLKTSMKFVKNVIAGIRETEEKFYYIVQEEKNYRESLTHCRIRGGMLAMPKDEAANTLIADYVAKSGFFRVFIGVNDLEREGQYMFTDNTPLQNYSNWNEGEPSDPYGHEDCVEMLSSGRWNDTECHLTMYFVCEFIKKKK
UniProt ID: Q9Z0E8
Variant: L -> R at position 352-352
Variant annotation: in JVS
Protein function: Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Reference sequence:
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQESCLDGWEYDKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQVFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSELQDLNSTKPQLHHIYDLIRTRNIRVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFFPESFGVPLPDTIDQMLRVKGIKQWQIQSQTRMQKDGEESPTVLKSTAF
UniProt ID: Q9Z0F0
Variant: W -> R at position 248-248
Variant annotation: in strain: pgn2
Protein function: Involved in GM1/GD1B/GA1 ganglioside biosynthesis.
Reference sequence:
MPLSLFRRVLLAVLLLVIIWTLFGPSGLGEELLSLSLASLLPAPASPGPPLALPRLLISNSHACGGSGPPPFLLILVCTAPEHLNQRNAIRASWGAIREARGFRVQTLFLLGKPRRQQLADLSSESAAHRDILQASFQDSYRNLTLKTLSGLNWVNKYCPMARYILKTDDDVYVNVPELVSELIQRGGPSEQWQKGKEAQEETTAIHEEHRGQAVPLLYLGRVHWRVRPTRTPESRHHVSEELWPENWGPFPPYASGTGYVLSISAVQLILKVASRAPPLPLEDVFVGVSARRGGLAPTHCVKLAGATHYPLDRCCYGKFLLTSHKVDPWQMQEAWKLVSGMNGERTAPFCSWLQGFLGTLRCRFIAWFSS
UniProt ID: Q9Z0F0
Variant: G -> W at position 344-344
Variant annotation: in strain: BLG2/Msf
Protein function: Involved in GM1/GD1B/GA1 ganglioside biosynthesis.
Reference sequence:
MPLSLFRRVLLAVLLLVIIWTLFGPSGLGEELLSLSLASLLPAPASPGPPLALPRLLISNSHACGGSGPPPFLLILVCTAPEHLNQRNAIRASWGAIREARGFRVQTLFLLGKPRRQQLADLSSESAAHRDILQASFQDSYRNLTLKTLSGLNWVNKYCPMARYILKTDDDVYVNVPELVSELIQRGGPSEQWQKGKEAQEETTAIHEEHRGQAVPLLYLGRVHWRVRPTRTPESRHHVSEELWPENWGPFPPYASGTGYVLSISAVQLILKVASRAPPLPLEDVFVGVSARRGGLAPTHCVKLAGATHYPLDRCCYGKFLLTSHKVDPWQMQEAWKLVSGMNGERTAPFCSWLQGFLGTLRCRFIAWFSS
UniProt ID: Q9Z1K8
Variant: S -> T at position 4-4
Protein function: Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis via transport of L-arginine, and is involved in the transport of L-arginine in monocytes.
Reference sequence:
MVNSTKYEVAAQHEADDGSALGDGASPVAEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLMYSASFGLSLVIWAVGGIFSVFGALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLLIIEPTSQAVIAITFANYMVQPLFPSCGAPYAAGRLLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLALIAVIIAGIVRLGQGATANFENSFEGSSFAMGDIALALYSALFSYSGWDTLNYVTEEIRNPERNLPLSIGISMPIVTIIYLLTNVAYYSVLDIKEILASDAVAVTFADQIFGVFNWIIPVAVAFSCFGGLNASIVAASRLLFVGSREGHLPDAICMVHVERFTPVPSLLFNGVLSLVYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRWKDPDRPRPLKLSLFFPIIFCLCTIFLVAVPLYSDTINSLIGIGIALSGLPFYFFIIRVPEHKRPLFLRRIVASITRYLQILCMSVAAEMDLEDGELSKQDPKSK
UniProt ID: Q9Z1P1
Variant: G -> E at position 10-10
Variant annotation: in Lec15.1/B4-2-1 cell line
Protein function: Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the GPI-GNT complex.
Reference sequence:
MATGTDQVVGFGLVAVSLIIFTYYTTWVILLPFIDSQHVIHKYFLPRAYAVLIPLATGLLLLLFVGLFITYVMLKSRRLTKKAQ
UniProt ID: Q9Z6S1
Variant: L -> F at position 186-186
Variant annotation: in strain: CWL029 and TW-183
Protein function: Cell wall formation.
Reference sequence:
MKEAAPMHFPFPVRRSVWLNRYSTFRIGGPANYFKAIHTIEEAREVIRFLHSINYPFLIIGKGSNCLFDDRGFDGFVLYNAIYGKQFLEDARIKAYSGLSFAALGKATAYNGYSGLEFAAGIPGSVGGAIFMNAGTNESDISSVVRNVETINSEGELCSYSVEELELSYRSSRFHRQQEFILSATLQLSKKQVSADHSKSILQHRLMTQPYTQPSAGCIFRNPEGTSAGKLIDAAGLKGLAIGGAQISPLHANFIINTGKATSDEVKQLIAIIQSTLKTQGIDLEHEIRIIPYQPKIHSPVSEK
UniProt ID: Q9Z6T7
Variant: R -> W at position 48-48
Variant annotation: in strain: TW-183
Protein function: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
Reference sequence:
MFKFFRNKLQSLFKKNISLDLIEDAESLFYEADFGTELTEELCARLRRTKKADASTIKDLITVLLRESLEGLPSQASQSSQTRPIVSLLLGTNGSGKTTTAAKLAHYYKERSESVMLVATDTFRAAGMDQARLWANELGCGFVSGQPGGDAAAIAFDGIQSAIARGYSRVIIDTSGRLHVHGNLMKELSKIVSVCGKALEGAPHEIFMTVDSTLGNNAIEQVRVFHDVVPLSGLIFTKVDGSAKGGTLFQIAKRLKIPTKFIGYGESLKDLNEFDLDLFLNKLFPEVEKI
UniProt ID: Q9Z7C9
Variant: G -> R at position 353-353
Variant annotation: in strain: CWL029 and TW-183
Protein function: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Reference sequence:
MVWVFKSQFEGLSALKRGVHALTKAVTPAFGPRGYNVVIKKGKAPIVLTKNGIRIAKEIILQDAFESLGVKLAKEALLKVVEQTGDGSTTALVVIDALFTQGLKGIAAGLDPQEIKAGILLSVEMVYQQLQRQAIELQSPKDVLHVAMVAANHDVTLGTVVATVISQADLKGVFSSKDSGISKTRGLGKRVKSGYLSPYFVTRPETMDVVWEEALVLILSHSLVSLSEELIRYLELISEQNTHPLVIIAEDFDQNVLRTLILNKLRNGLPVCAVKAPGSRELRQVVLEDLAILTGATLIGQESENCEIPVSLDVLGRVKQVMITKETFTFLEGGGDAEIIQARKQELCLAIAGSTSESECQELEERLAIFIGSIPQVQITADTDTEQRERQFQLESALRATKAAMKGGIVPGGGVAFLRAAHAIEVPANLSSGMTFGFETLLQAVRTPLKVLAQNCGRSSEEVIHTILSHENPRFGYNGMTDTFEDLVDAGICDPLIVTTSSLKCAVSVSCLLLTSSFFISSRTKT
UniProt ID: Q9Z7S8
Variant: I -> T at position 372-372
Variant annotation: in strain: CWL029 and TW-183
Protein function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Reference sequence:
MSDNAHNLLYDKFELPEAVKMLPVEGLPIDKHARFIAEPLERGMGHTLGNALRRALLIGLEAPAIISFAMTGVLHEYMAIEGVIEDVTNIILNLKGALLKKYPMQDSSLGRTTQVLKASISIDASDLAAANGQKEVTLQDLLQEGDFEAVNPDQVIFTVTQPIQLEVVLRIAFGRGYTPSERIVLEDKGVYEIVLDAAFSPVTLVNYFVEDTRVGQDTDFDRLVLIVETDGRVTPKEALAFSTQILTKHFSIFENMDEKKIVFEEAISIEKENKDDILHKLILGINEIELSVRSTNCLSNANIETIGELVIMPEPRLLQFRNFGKKSLCEIKNKLKEMKLELGMDLTQFGVGLDNVKEKMKWYAEKIRAKNIKG
UniProt ID: Q9Z7X4
Variant: T -> A at position 108-108
Variant annotation: in strain: CWL029 and TW-183
Protein function: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Reference sequence:
MTKVALLIAYQGTAYSGWQQQPNDLSIQEVIESSLKKITKTRTPLIASGRTDAGVHAYGQVAHFRAPDHPLFANANLTKKALNAILPKDIVIRDVALFDDNFHARYLTIAKEYRYSLSRLAKPLPWQRHFCYTPRHPFSTELMQEGANLLIGTHDFASFANHGRDYNSTVRTIYTLDIVDKGDSLSIICRGNGFLYKMVRNLVGALLDVGKGAYPPEHLLDILEQKNRREGPSAAPAYGLSLHHVCYSSPYNNFCCEQCSVSTSNEG
UniProt ID: Q9Z869
Variant: Y -> H at position 139-139
Variant annotation: in strain: AR39 and J138
Protein function: Probably part of an ABC transporter complex involved in arginine transport. Binds arginine. Interacts with host epithelial cells, suggesting a role in host-cell adhesion during infection.
Reference sequence:
MIKQIGRFFRAFIFIMPLSLTSCESKIDRNRIWIVGTNATYPPFEYVDAQGEVVGFDIDLAKAISEKLGKQLEVREFAFDALILNLKKHRIDAILAGMSITPSRQKEIALLPYYGDEVQELMVVSKRSLETPVLPLTQYSSVAVQTGTFQEHYLLSQPGICVRSFDSTLEVIMEVRYGKSPVAVLEPSVGRVVLKDFPNLVATRLELPPECWVLGCGLGVAKDRPEEIQTIQQAITDLKSEGVIQSLTKKWQLSEVAYE
UniProt ID: Q9Z8F3
Variant: T -> A at position 168-168
Variant annotation: in strain: CWL029 and TW-183
Protein function: The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
Reference sequence:
MTHQVAVLHQDKKFDVSLRPKGLEEFYGQHHLKERLDLFLCAALQRGEVPGHCLFFGPPGLGKTSLAHIVAYTVGKGLVLASGPQLIKPSDLLGLLTSLQEGDVFFIDEIHRMGKVAEEYLYSAMEDFKVDITIDSGPGARSVRVDLAPFTLVGATTRSGMLSEPLRTRFAFSARLSYYSDQDLKEILVRSSHLLGIEADSSALLEIAKRSRGTPRLANHLLRWVRDFAQIREGNCINGDVAEKALAMLLIDDWGLNEIDIKLLTTIIDYYQGGPVGIKTLSVAVGEDIKTLEDVYEPFLILKGFIKKTPRGRMVTQLAYDHLKRHAKNLLSLGEGQ
UniProt ID: Q9Z8U8
Variant: R -> K at position 279-279
Variant annotation: in strain: CWL029 and TW-183
Protein function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
Reference sequence:
MPFKCIFLTGGVVSSLGKGLTAASLALILERQRLNVAMLKLDPYLNVDPGTMNPFEHGEIYVTDDGVETDLDLGHYHRFSSAALSRHSSATSGQIYARVIKREREGDYLGSTVQVIPHITNEIIQVILDAAKEHSPDVLIVEIGGTIGDIESLPFLEAIRQFRYDHSEDCLNIHMTYVPYLQAADEVKSKPTQHSVQTLRGIGIIPDAILCRSEKPLTQEVKSKISLFCNVPNRAVFNVIDVKHTIYEMPLMLAQEKIANFIGEKLKLATVPENLDDWRVLVNQLSQDLPKVKIGVVGKYVQHRDAYKSIFEALTHAALRLGHAAEIIPIDAEDENLTMELSQCDACLVPGGFGVRGWEGKIAAAKFCREQGIPYFGICLGMQVLVVEYARNVLNLDQANSLEMDPNTPHPIVYVMEGQDPLVATGGTMRLGAYPCLLKPGSKAHKAYNESSLIQERHRHRYEVNPDYIQSLEDHGLRIVGTCPPQGLCEIIEVSDHPWMIGVQFHPEFVSKLISPHPLFIAFIEAALVYSKDASHV
UniProt ID: Q9Z959
Variant: V -> A at position 423-423
Variant annotation: in strain: CWL029 and TW-183
Protein function: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Reference sequence:
MPQKVLITSALPYANGPLHFGHIAGVYLPADVYARFRRLLGDDVLYICGSDEFGIAITLNADREGLGYQEYVDMYHKLHKDTFEKLGFALDFFSRTTNPFHAELVQDFYSQLKASGLIENRISEQLYSEQEQRFLADRYVEGTCPRCGFDHARGDECQSCGADYEAIDLIDPKSKISGVELVKKETEHSYFLLDRMKDALLSFIQGCYLPDHVRKFVVDYIEHVRSRAITRDLSWGIPVPDFPGKVFYVWFDAPIGYISGTMEWAASQGNPDEWKRFWLEDGVEYVQFIGKDNLPFHSVVFPAMELGQKLDYKKVDALVVSEFYLLEGRQFSKSEGNYVDMDKFLSSYSLDKLRYVLAATAPETSDSEFTFLDFKTRCNSELVGKFGNFINRVLAFAEKNHYDKLSYHSVVLEDSDRAFLEEVRQLVRDAEKCYREYSLRKATSVIMSLAALGNVYFNQQAPWKLLKEGTRERVEAILFCACYCQKLLALISYPIIPESAVAIWEMISPKSLENCNLDTMYARDLWKEEILDVINEEFHLKSPRLLFTTVE
UniProt ID: Q9Z9A5
Variant: T -> M at position 140-140
Variant annotation: in strain: CWL029 and TW-183
Protein function: Participates in transcription elongation, termination and antitermination.
Reference sequence:
MYKWYVVQVFTAQEKKVKKALEDFKESSGMTDFIQEIILPIENVMEVKKGEHKVVEKYIWPGYLLVKMHLTDESWLYVKSTAGIVEFLGGGVPVALSEDEVRSILTDIEEKKSGVVQKHQFEVGSRVKINDGVFVNFIGTVSEVFHDKGRLSVMVSIFGRETRVDDLEFWQVEEVAPGQESE
UniProt ID: Q9ZCT7
Variant: GS -> VQ at position 9-10
Variant annotation: in strain: Breinl
Protein function: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Reference sequence:
MTTKLIKHGSKAREQMLEGIDILADAVKVTLGPKGRNVLIEQSFGAPKITKDGVTVAKSIELKDKIKNAGAQLLKSAATKAAEVAGDGTTTATVLARALAREGNKLVAAGYNPMDLKRGMDLAVNAVVEEIKRSSKKINSQEEIAQVGTISSNGDKEIGEKIAKAMEEVGKEGVITVEEAKNFSFDVEVVKGMMFDRGYLSPYFVTNSEKMVAELENPFILLFEKKLSNLQPMLPILEAVVQSQRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMMEDIAILTKGELITEDLGMKLENVNIKNLGTAKRVTISKENTVIVDGNGDKKNIEDRVLQIKSQIAETTSDYDKEKLQERLAKLSGGVAVLKVGGATEVEVKERKDRVEDALAATRAAVEEGVVAGGGVTLLHASQTLTKLKVENKDQQAGIEIVIEALKDPLKQIVKNAGENGGVVVGKLLEHNDKNYGFNAQDMQYVDMIKAGIIDPAKVVRTALQDAASVASLIITTETLIVDEPSDKEEPMPMRGGMGGMGGMGGMDF
UniProt ID: Q9ZCT7
Variant: E -> Q at position 432-432
Variant annotation: in strain: Breinl
Protein function: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Reference sequence:
MTTKLIKHGSKAREQMLEGIDILADAVKVTLGPKGRNVLIEQSFGAPKITKDGVTVAKSIELKDKIKNAGAQLLKSAATKAAEVAGDGTTTATVLARALAREGNKLVAAGYNPMDLKRGMDLAVNAVVEEIKRSSKKINSQEEIAQVGTISSNGDKEIGEKIAKAMEEVGKEGVITVEEAKNFSFDVEVVKGMMFDRGYLSPYFVTNSEKMVAELENPFILLFEKKLSNLQPMLPILEAVVQSQRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMMEDIAILTKGELITEDLGMKLENVNIKNLGTAKRVTISKENTVIVDGNGDKKNIEDRVLQIKSQIAETTSDYDKEKLQERLAKLSGGVAVLKVGGATEVEVKERKDRVEDALAATRAAVEEGVVAGGGVTLLHASQTLTKLKVENKDQQAGIEIVIEALKDPLKQIVKNAGENGGVVVGKLLEHNDKNYGFNAQDMQYVDMIKAGIIDPAKVVRTALQDAASVASLIITTETLIVDEPSDKEEPMPMRGGMGGMGGMGGMDF
UniProt ID: Q9ZE20
Variant: S -> G at position 33-33
Variant annotation: in strain: Breinl
Protein function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Reference sequence:
MSVVNFYGQLSNTQQFDQIRINIASPDQVRSWSFGEVTKPETINYRTFKPEKDGLFCARIFGPVKDYECLCGKYKRMKNRGITCEKCGVEVTVSRVRRERMGHIELAAPVAHIWFLKSLPSRISTLLDMTMRDVEKILYFENYVVVDPGLSILQKGELLTEEELQKAKDKYGEDAFTASIGAEVIQQMLKELDFSKLKQELYDELHITSSEVKKKKLVKRLKLVEDFLESENKPEWMIMDVLPVIPPEIRPLVMLDGGRFATSDLNELYRRVINRNNRLKKLIESKAPDIIVRNEKRMLQEAVDALFDNGRRGRAAKNANKRPFKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHQCGLPKKMALELFKPFIYSKLELYGIATTIKAAKRMVEAEKPEVWDVLEEVIREHPVLLNRAPTLHRLGIQAFEPLLIEGKAIQLHPLVCAAFNADFDGDQMAVHIPLSIEAQLEARVFMMSTNNILSPANGRPIIVPDKDIVLGLYYLTIAFDNEVGEGMMFSDLAEMEHALYNKFITIHTKIKYRRDQLNAEGKMVPVIIDTTYGRLMVGELLPSNPNIEFKFINKQLTKKDISLVIDLVYRHCGQKATVIFADQLMKLGFKYACSSGISFGMDDMVVPESKSTHINETQLEIKEFEQQYSNGLITYGEKYNKVVDAWSRCTDRVANDMMKEIATPPVNDYPNHQKINAIYMMAISGARGSFQQIKQLGGMRGLMTKSNGQIIQTPIISNFKEGLTEFECFNSANGMRKGQIDTALKTASSGYLTRKLVDVAQDCIITEKDCGTDKGIEVKSVIEGGEIIVPLAEKILGRTAAIDIFHPVTNDLILNKGELINESKLEQIESAGLDRIMIKSVLTCESSTGICSICYGRDLATGTLVSEGEAIGVIAAQSIGEPGTQLTMRTFHIGGAATKGAEVSSVEASYDAKVKIISRNVVINSEERKIVMSRNCELLLLDNNGNEKARHKIPYGARLLVDDGDMVIKTQKLAEWDPYTIPIITEKSGKVLFKDMVEGISIRDVTDEATGIPSKVIIESKQYSRGAELRPRIQLLDSKGEVITLSNGLEARYYLPVGAVLSVEDGIQISVGDIIARIPKESTTTKDITGGLPRVAELVEARRPKDHAVIAEVDGRVEFGKDYKSKRRIIIHPIDGTMSIEYMVPKGKHVVVNEGDFVKKGDLLIDGNPVLQDILKVMGVEVLANYIVKEVQAVYRLQGVKIDDKHIEVIIRQMLQKVEVTDSGGTTLLVGEKIDRHEFDEINAKAMKNGLKPAEAQLILQGITKASLQTRSFISAASFQETTRVLTEAAIAGKVDKLRGLKENVIVGRLVPAGTGYFMDKMRKAAVKLDEENV
UniProt ID: Q9ZEE3
Variant: E -> D at position 29-29
Variant annotation: in strain: 12261
Protein function: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
Reference sequence:
GDNILKVDSFLTHQVDFSLMREIGKVFAEKFASAGITKVVTIEASGIAPAVFTAEALNVPMIFAKKAKNITMNEGILTAQVYSFTKQVTSTVSIAGKFLSPEDKVLIIDDFLANGQAAKGLIQIIEQAGATVEAIGIVIEKSFQDGRDLLEKAGYPVLSLAR
UniProt ID: Q9ZEE3
Variant: V -> I at position 51-51
Variant annotation: in strain: 12261
Protein function: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
Reference sequence:
GDNILKVDSFLTHQVDFSLMREIGKVFAEKFASAGITKVVTIEASGIAPAVFTAEALNVPMIFAKKAKNITMNEGILTAQVYSFTKQVTSTVSIAGKFLSPEDKVLIIDDFLANGQAAKGLIQIIEQAGATVEAIGIVIEKSFQDGRDLLEKAGYPVLSLAR
UniProt ID: Q9ZEE3
Variant: N -> D at position 58-58
Variant annotation: in strain: 12261
Protein function: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
Reference sequence:
GDNILKVDSFLTHQVDFSLMREIGKVFAEKFASAGITKVVTIEASGIAPAVFTAEALNVPMIFAKKAKNITMNEGILTAQVYSFTKQVTSTVSIAGKFLSPEDKVLIIDDFLANGQAAKGLIQIIEQAGATVEAIGIVIEKSFQDGRDLLEKAGYPVLSLAR
UniProt ID: Q9ZEE3
Variant: T -> K at position 131-131
Variant annotation: in strain: 12261
Protein function: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
Reference sequence:
GDNILKVDSFLTHQVDFSLMREIGKVFAEKFASAGITKVVTIEASGIAPAVFTAEALNVPMIFAKKAKNITMNEGILTAQVYSFTKQVTSTVSIAGKFLSPEDKVLIIDDFLANGQAAKGLIQIIEQAGATVEAIGIVIEKSFQDGRDLLEKAGYPVLSLAR
UniProt ID: Q9ZHC5
Variant: T -> K at position 12-12
Variant annotation: in strain: LR222
Protein function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
Reference sequence:
MNKAELIDVLTTKMGTDRRQATAAVENVVDTIVRAVHKGDSVTITGFGVFEQRRRAARVARNPRTGETVKVKPTSVPAFRPGAQFKAVISGAQKLPADGPAVKRGVTAGPAKKAAKKAPAKKAAAKKTATKAAAKKAPAKKAATKAPAKKAATKAPAKKAATKAPAKKAATKAPAKKAAAKAPAKKAATKAPAKKAAAKKAPAKKGRR
UniProt ID: Q9ZHC5
Variant: G -> N at position 15-15
Variant annotation: in strain: LR222
Protein function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
Reference sequence:
MNKAELIDVLTTKMGTDRRQATAAVENVVDTIVRAVHKGDSVTITGFGVFEQRRRAARVARNPRTGETVKVKPTSVPAFRPGAQFKAVISGAQKLPADGPAVKRGVTAGPAKKAAKKAPAKKAAAKKTATKAAAKKAPAKKAATKAPAKKAATKAPAKKAATKAPAKKAATKAPAKKAAAKAPAKKAATKAPAKKAAAKKAPAKKGRR
UniProt ID: Q9ZN78
Variant: P -> S at position 115-115
Variant annotation: in mutant HO1; lacks DNA-binding activity
Protein function: Represses adpA expression by binding to the promoter region in the absence of A-factor, causing repression of streptomycin production and of sporulation.
Reference sequence:
MAKQARAVQTWRSIVDAAASVFDDYGYERAAISEILRRAKVTKGALYFHFASKEAIAQAIMDEQTSTVEFEQEGSPLQSLVDGGQQFAFALRHNSMARAGTRLSIEGVFLGGPHPWGDWIDATARMLELGQERGEVFPQIDPMVSAKIIVASFTGIQLVSEADSGRADLRGQVAEMWRHILPSIAHPGVIAHIKPEGRVDLAAQAREKAEREEQEARIAAEAKGAGSDAATDSGSRSGGSGLRGGGSGRGPRAGGAGDEGDEEPAGAGVAAGGVVA
UniProt ID: Q9ZN78
Variant: G -> E at position 171-171
Variant annotation: in strain: IFO 13350
Protein function: Represses adpA expression by binding to the promoter region in the absence of A-factor, causing repression of streptomycin production and of sporulation.
Reference sequence:
MAKQARAVQTWRSIVDAAASVFDDYGYERAAISEILRRAKVTKGALYFHFASKEAIAQAIMDEQTSTVEFEQEGSPLQSLVDGGQQFAFALRHNSMARAGTRLSIEGVFLGGPHPWGDWIDATARMLELGQERGEVFPQIDPMVSAKIIVASFTGIQLVSEADSGRADLRGQVAEMWRHILPSIAHPGVIAHIKPEGRVDLAAQAREKAEREEQEARIAAEAKGAGSDAATDSGSRSGGSGLRGGGSGRGPRAGGAGDEGDEEPAGAGVAAGGVVA
UniProt ID: Q9ZN78
Variant: AATDSGS -> PTSEGGT at position 229-235
Variant annotation: in strain: IFO 13350
Protein function: Represses adpA expression by binding to the promoter region in the absence of A-factor, causing repression of streptomycin production and of sporulation.
Reference sequence:
MAKQARAVQTWRSIVDAAASVFDDYGYERAAISEILRRAKVTKGALYFHFASKEAIAQAIMDEQTSTVEFEQEGSPLQSLVDGGQQFAFALRHNSMARAGTRLSIEGVFLGGPHPWGDWIDATARMLELGQERGEVFPQIDPMVSAKIIVASFTGIQLVSEADSGRADLRGQVAEMWRHILPSIAHPGVIAHIKPEGRVDLAAQAREKAEREEQEARIAAEAKGAGSDAATDSGSRSGGSGLRGGGSGRGPRAGGAGDEGDEEPAGAGVAAGGVVA
UniProt ID: Q9ZN78
Variant: GA -> VT at position 255-256
Variant annotation: in strain: IFO 13350
Protein function: Represses adpA expression by binding to the promoter region in the absence of A-factor, causing repression of streptomycin production and of sporulation.
Reference sequence:
MAKQARAVQTWRSIVDAAASVFDDYGYERAAISEILRRAKVTKGALYFHFASKEAIAQAIMDEQTSTVEFEQEGSPLQSLVDGGQQFAFALRHNSMARAGTRLSIEGVFLGGPHPWGDWIDATARMLELGQERGEVFPQIDPMVSAKIIVASFTGIQLVSEADSGRADLRGQVAEMWRHILPSIAHPGVIAHIKPEGRVDLAAQAREKAEREEQEARIAAEAKGAGSDAATDSGSRSGGSGLRGGGSGRGPRAGGAGDEGDEEPAGAGVAAGGVVA
UniProt ID: Q9ZN78
Variant: V -> I at position 274-274
Variant annotation: in strain: IFO 13350
Protein function: Represses adpA expression by binding to the promoter region in the absence of A-factor, causing repression of streptomycin production and of sporulation.
Reference sequence:
MAKQARAVQTWRSIVDAAASVFDDYGYERAAISEILRRAKVTKGALYFHFASKEAIAQAIMDEQTSTVEFEQEGSPLQSLVDGGQQFAFALRHNSMARAGTRLSIEGVFLGGPHPWGDWIDATARMLELGQERGEVFPQIDPMVSAKIIVASFTGIQLVSEADSGRADLRGQVAEMWRHILPSIAHPGVIAHIKPEGRVDLAAQAREKAEREEQEARIAAEAKGAGSDAATDSGSRSGGSGLRGGGSGRGPRAGGAGDEGDEEPAGAGVAAGGVVA