sujigwak/NVAR huggingface dataset:
UniProt ID: Q9G0S9
Variant: I -> V at position 78-78
Variant annotation: in strain: Isolate Jorg 64
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTNIRKTHPLMKIMNNSFIDLPAPSNISSWWNFGSLLGACLVIQIITGLFLAMHYTADTTTAFSSVTHICRDVNQGWIIRYLHANGASMFFLCLFLHVGRGMYYGSFTLTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYMGTDLVEWIWGGFSVDKATLTRFFAFHFILPFVILALVMVHLLFLHETGSNNPLGIPSESDKIPFHPYYTIKDLLGLMFLLITLMILVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIIPMLQTAKQRSMTFRPLSQIMFWILTADLLILTWIGGQPVEHPFVTIGQVASILYFSLILIIMPTVSLFENKMLKW
UniProt ID: Q9G0S9
Variant: T -> N at position 158-158
Variant annotation: in strain: Isolate YLE357
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTNIRKTHPLMKIMNNSFIDLPAPSNISSWWNFGSLLGACLVIQIITGLFLAMHYTADTTTAFSSVTHICRDVNQGWIIRYLHANGASMFFLCLFLHVGRGMYYGSFTLTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYMGTDLVEWIWGGFSVDKATLTRFFAFHFILPFVILALVMVHLLFLHETGSNNPLGIPSESDKIPFHPYYTIKDLLGLMFLLITLMILVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIIPMLQTAKQRSMTFRPLSQIMFWILTADLLILTWIGGQPVEHPFVTIGQVASILYFSLILIIMPTVSLFENKMLKW
UniProt ID: Q9G0S9
Variant: F -> Y at position 183-183
Variant annotation: in strain: Isolate Jorg 33
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTNIRKTHPLMKIMNNSFIDLPAPSNISSWWNFGSLLGACLVIQIITGLFLAMHYTADTTTAFSSVTHICRDVNQGWIIRYLHANGASMFFLCLFLHVGRGMYYGSFTLTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYMGTDLVEWIWGGFSVDKATLTRFFAFHFILPFVILALVMVHLLFLHETGSNNPLGIPSESDKIPFHPYYTIKDLLGLMFLLITLMILVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIIPMLQTAKQRSMTFRPLSQIMFWILTADLLILTWIGGQPVEHPFVTIGQVASILYFSLILIIMPTVSLFENKMLKW
UniProt ID: Q9G0S9
Variant: L -> M at position 185-185
Variant annotation: in strain: Isolate RMR 24
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTNIRKTHPLMKIMNNSFIDLPAPSNISSWWNFGSLLGACLVIQIITGLFLAMHYTADTTTAFSSVTHICRDVNQGWIIRYLHANGASMFFLCLFLHVGRGMYYGSFTLTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYMGTDLVEWIWGGFSVDKATLTRFFAFHFILPFVILALVMVHLLFLHETGSNNPLGIPSESDKIPFHPYYTIKDLLGLMFLLITLMILVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIIPMLQTAKQRSMTFRPLSQIMFWILTADLLILTWIGGQPVEHPFVTIGQVASILYFSLILIIMPTVSLFENKMLKW
UniProt ID: Q9G0S9
Variant: P -> T at position 186-186
Variant annotation: in strain: Isolate YLE74
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTNIRKTHPLMKIMNNSFIDLPAPSNISSWWNFGSLLGACLVIQIITGLFLAMHYTADTTTAFSSVTHICRDVNQGWIIRYLHANGASMFFLCLFLHVGRGMYYGSFTLTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYMGTDLVEWIWGGFSVDKATLTRFFAFHFILPFVILALVMVHLLFLHETGSNNPLGIPSESDKIPFHPYYTIKDLLGLMFLLITLMILVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIIPMLQTAKQRSMTFRPLSQIMFWILTADLLILTWIGGQPVEHPFVTIGQVASILYFSLILIIMPTVSLFENKMLKW
UniProt ID: Q9G0S9
Variant: V -> I at position 195-195
Variant annotation: in strain: Isolate RMR 44
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTNIRKTHPLMKIMNNSFIDLPAPSNISSWWNFGSLLGACLVIQIITGLFLAMHYTADTTTAFSSVTHICRDVNQGWIIRYLHANGASMFFLCLFLHVGRGMYYGSFTLTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYMGTDLVEWIWGGFSVDKATLTRFFAFHFILPFVILALVMVHLLFLHETGSNNPLGIPSESDKIPFHPYYTIKDLLGLMFLLITLMILVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIIPMLQTAKQRSMTFRPLSQIMFWILTADLLILTWIGGQPVEHPFVTIGQVASILYFSLILIIMPTVSLFENKMLKW
UniProt ID: Q9G0S9
Variant: F -> L at position 234-234
Variant annotation: in strain: Isolate Jorg 64
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTNIRKTHPLMKIMNNSFIDLPAPSNISSWWNFGSLLGACLVIQIITGLFLAMHYTADTTTAFSSVTHICRDVNQGWIIRYLHANGASMFFLCLFLHVGRGMYYGSFTLTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYMGTDLVEWIWGGFSVDKATLTRFFAFHFILPFVILALVMVHLLFLHETGSNNPLGIPSESDKIPFHPYYTIKDLLGLMFLLITLMILVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIIPMLQTAKQRSMTFRPLSQIMFWILTADLLILTWIGGQPVEHPFVTIGQVASILYFSLILIIMPTVSLFENKMLKW
UniProt ID: Q9G0S9
Variant: G -> D at position 251-251
Variant annotation: in strain: Isolate Jorg 64
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTNIRKTHPLMKIMNNSFIDLPAPSNISSWWNFGSLLGACLVIQIITGLFLAMHYTADTTTAFSSVTHICRDVNQGWIIRYLHANGASMFFLCLFLHVGRGMYYGSFTLTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYMGTDLVEWIWGGFSVDKATLTRFFAFHFILPFVILALVMVHLLFLHETGSNNPLGIPSESDKIPFHPYYTIKDLLGLMFLLITLMILVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIIPMLQTAKQRSMTFRPLSQIMFWILTADLLILTWIGGQPVEHPFVTIGQVASILYFSLILIIMPTVSLFENKMLKW
UniProt ID: Q9G0S9
Variant: T -> A at position 316-316
Variant annotation: in strain: Isolate Jorg 37
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTNIRKTHPLMKIMNNSFIDLPAPSNISSWWNFGSLLGACLVIQIITGLFLAMHYTADTTTAFSSVTHICRDVNQGWIIRYLHANGASMFFLCLFLHVGRGMYYGSFTLTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYMGTDLVEWIWGGFSVDKATLTRFFAFHFILPFVILALVMVHLLFLHETGSNNPLGIPSESDKIPFHPYYTIKDLLGLMFLLITLMILVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIIPMLQTAKQRSMTFRPLSQIMFWILTADLLILTWIGGQPVEHPFVTIGQVASILYFSLILIIMPTVSLFENKMLKW
UniProt ID: Q9G0S9
Variant: M -> I at position 324-324
Variant annotation: in strain: Isolate 00-016A-8EBC and Isolate RMR 24
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTNIRKTHPLMKIMNNSFIDLPAPSNISSWWNFGSLLGACLVIQIITGLFLAMHYTADTTTAFSSVTHICRDVNQGWIIRYLHANGASMFFLCLFLHVGRGMYYGSFTLTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYMGTDLVEWIWGGFSVDKATLTRFFAFHFILPFVILALVMVHLLFLHETGSNNPLGIPSESDKIPFHPYYTIKDLLGLMFLLITLMILVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIIPMLQTAKQRSMTFRPLSQIMFWILTADLLILTWIGGQPVEHPFVTIGQVASILYFSLILIIMPTVSLFENKMLKW
UniProt ID: Q9G0S9
Variant: M -> T at position 324-324
Variant annotation: in strain: Isolate YLE199
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTNIRKTHPLMKIMNNSFIDLPAPSNISSWWNFGSLLGACLVIQIITGLFLAMHYTADTTTAFSSVTHICRDVNQGWIIRYLHANGASMFFLCLFLHVGRGMYYGSFTLTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYMGTDLVEWIWGGFSVDKATLTRFFAFHFILPFVILALVMVHLLFLHETGSNNPLGIPSESDKIPFHPYYTIKDLLGLMFLLITLMILVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIIPMLQTAKQRSMTFRPLSQIMFWILTADLLILTWIGGQPVEHPFVTIGQVASILYFSLILIIMPTVSLFENKMLKW
UniProt ID: Q9G0S9
Variant: H -> Y at position 345-345
Variant annotation: in strain: Isolate 00-016A-8EBC, Isolate RMR 24 and Isolate YLE199
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTNIRKTHPLMKIMNNSFIDLPAPSNISSWWNFGSLLGACLVIQIITGLFLAMHYTADTTTAFSSVTHICRDVNQGWIIRYLHANGASMFFLCLFLHVGRGMYYGSFTLTETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYMGTDLVEWIWGGFSVDKATLTRFFAFHFILPFVILALVMVHLLFLHETGSNNPLGIPSESDKIPFHPYYTIKDLLGLMFLLITLMILVLFSPDLLGDPDNYMPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSILILAIIPMLQTAKQRSMTFRPLSQIMFWILTADLLILTWIGGQPVEHPFVTIGQVASILYFSLILIIMPTVSLFENKMLKW
UniProt ID: Q9G185
Variant: I -> V at position 61-61
Variant annotation: in strain: Isolate MSB 53282/NK 7980
Protein function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Reference sequence:
MAYPFELGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEIETIWTILPAIILILIALPSLRILYMMDEINDPSLTVKTMGHQWYWSYEYTDYEDLNFDSYMIPTSDLNPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATLTSTRPGLYYGQCSEICGSNHSFMPIVLELVPLKHFENWSSSML
UniProt ID: Q9G185
Variant: I -> V at position 123-123
Variant annotation: in strain: Isolate MSB 53282/NK 7980
Protein function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Reference sequence:
MAYPFELGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEIETIWTILPAIILILIALPSLRILYMMDEINDPSLTVKTMGHQWYWSYEYTDYEDLNFDSYMIPTSDLNPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATLTSTRPGLYYGQCSEICGSNHSFMPIVLELVPLKHFENWSSSML
UniProt ID: Q9G1R4
Variant: I -> M at position 11-11
Variant annotation: in strain: Isolate AF 3221
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTIIRKKHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVFVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLMGLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLALLPLLHTSKQRGLTFRPITQTMYWILVADLLILTWIGGQPVEYPFIIIGQMASIAYFTIIIILMPMAGMIENNILDLD
UniProt ID: Q9G1R4
Variant: S -> A at position 17-17
Variant annotation: in strain: Isolate AF 2664
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTIIRKKHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVFVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLMGLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLALLPLLHTSKQRGLTFRPITQTMYWILVADLLILTWIGGQPVEYPFIIIGQMASIAYFTIIIILMPMAGMIENNILDLD
UniProt ID: Q9G1R4
Variant: A -> T at position 23-23
Variant annotation: in strain: Isolate AF 3221
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTIIRKKHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVFVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLMGLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLALLPLLHTSKQRGLTFRPITQTMYWILVADLLILTWIGGQPVEYPFIIIGQMASIAYFTIIIILMPMAGMIENNILDLD
UniProt ID: Q9G1R4
Variant: C -> W at position 40-40
Variant annotation: in strain: Isolate AF 2664
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTIIRKKHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVFVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLMGLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLALLPLLHTSKQRGLTFRPITQTMYWILVADLLILTWIGGQPVEYPFIIIGQMASIAYFTIIIILMPMAGMIENNILDLD
UniProt ID: Q9G1R4
Variant: I -> A at position 42-42
Variant annotation: in strain: Isolate AF 3221
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTIIRKKHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVFVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLMGLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLALLPLLHTSKQRGLTFRPITQTMYWILVADLLILTWIGGQPVEYPFIIIGQMASIAYFTIIIILMPMAGMIENNILDLD
UniProt ID: Q9G1R4
Variant: I -> T at position 42-42
Variant annotation: in strain: Isolate AF 2664
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTIIRKKHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVFVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLMGLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLALLPLLHTSKQRGLTFRPITQTMYWILVADLLILTWIGGQPVEYPFIIIGQMASIAYFTIIIILMPMAGMIENNILDLD
UniProt ID: Q9G1R4
Variant: M -> T at position 237-237
Variant annotation: in strain: Isolate AF 3221
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTIIRKKHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVFVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLMGLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLALLPLLHTSKQRGLTFRPITQTMYWILVADLLILTWIGGQPVEYPFIIIGQMASIAYFTIIIILMPMAGMIENNILDLD
UniProt ID: Q9G1R4
Variant: N -> S at position 286-286
Variant annotation: in strain: Isolate AF 4995
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTIIRKKHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVFVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLMGLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLALLPLLHTSKQRGLTFRPITQTMYWILVADLLILTWIGGQPVEYPFIIIGQMASIAYFTIIIILMPMAGMIENNILDLD
UniProt ID: Q9G1R4
Variant: V -> I at position 300-300
Variant annotation: in strain: Isolate AF 2664 and Isolate AF 3221
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTIIRKKHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVFVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLMGLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLALLPLLHTSKQRGLTFRPITQTMYWILVADLLILTWIGGQPVEYPFIIIGQMASIAYFTIIIILMPMAGMIENNILDLD
UniProt ID: Q9G1R4
Variant: I -> V at position 349-349
Variant annotation: in strain: Isolate AF 3221
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTIIRKKHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVFVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLMGLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLALLPLLHTSKQRGLTFRPITQTMYWILVADLLILTWIGGQPVEYPFIIIGQMASIAYFTIIIILMPMAGMIENNILDLD
UniProt ID: Q9G1R4
Variant: T -> A at position 360-360
Variant annotation: in strain: Isolate AF 2664 and Isolate AF 3221
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTIIRKKHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVFVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLMGLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLALLPLLHTSKQRGLTFRPITQTMYWILVADLLILTWIGGQPVEYPFIIIGQMASIAYFTIIIILMPMAGMIENNILDLD
UniProt ID: Q9G1R4
Variant: I -> V at position 363-363
Variant annotation: in strain: Isolate AF 2664 and Isolate AF 3221
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MTIIRKKHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVFVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLMGLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLALILSILVLALLPLLHTSKQRGLTFRPITQTMYWILVADLLILTWIGGQPVEYPFIIIGQMASIAYFTIIIILMPMAGMIENNILDLD