sujigwak/NVAR huggingface dataset:
UniProt ID: Q28849
Variant: A -> V at position 107-107
Variant annotation: in Mac-B
Protein function: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
Reference sequence:
MSSKYPRSVRCCLPLWALTLEAALILLFFFFTYYDASLEDQKGLVASYQVCQDLTVMAVLGLGFFTSNLRRNSWSSVAFNLFLLALGVQWAILLDGFLSQFSPGKVAIKLFSIRLATRSTMSMLISMNAVLGKVNLVQLVVMELVELTVFGTMRIVINNIFKIDYGMNMMHIHVFAAYFGLTVAWCLPKPLPKGTEDKYQTTTSPSLFAMLGTLFLWMFWPTFNSALLLNPIERKNAVFSTYYALAVSAVTAISVSSLAHPGGKINMTYMHNAALAGGVALSASCHVIHSPWIAMVLGLVAGLISIGGAKCLPVCFNRVLGIHESHSVHYTFGLPALLGEITYIVLMALRVVWASSNMIGFQVLLSTGTLSLAMAMSITSGLLTGLLLNLKIWKGPHVAKYFDDQAFWEFPHLAVGF
UniProt ID: Q28849
Variant: P -> L at position 192-192
Variant annotation: in Mac-B
Protein function: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
Reference sequence:
MSSKYPRSVRCCLPLWALTLEAALILLFFFFTYYDASLEDQKGLVASYQVCQDLTVMAVLGLGFFTSNLRRNSWSSVAFNLFLLALGVQWAILLDGFLSQFSPGKVAIKLFSIRLATRSTMSMLISMNAVLGKVNLVQLVVMELVELTVFGTMRIVINNIFKIDYGMNMMHIHVFAAYFGLTVAWCLPKPLPKGTEDKYQTTTSPSLFAMLGTLFLWMFWPTFNSALLLNPIERKNAVFSTYYALAVSAVTAISVSSLAHPGGKINMTYMHNAALAGGVALSASCHVIHSPWIAMVLGLVAGLISIGGAKCLPVCFNRVLGIHESHSVHYTFGLPALLGEITYIVLMALRVVWASSNMIGFQVLLSTGTLSLAMAMSITSGLLTGLLLNLKIWKGPHVAKYFDDQAFWEFPHLAVGF
UniProt ID: Q28849
Variant: G -> R at position 262-262
Variant annotation: in Mac-B
Protein function: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
Reference sequence:
MSSKYPRSVRCCLPLWALTLEAALILLFFFFTYYDASLEDQKGLVASYQVCQDLTVMAVLGLGFFTSNLRRNSWSSVAFNLFLLALGVQWAILLDGFLSQFSPGKVAIKLFSIRLATRSTMSMLISMNAVLGKVNLVQLVVMELVELTVFGTMRIVINNIFKIDYGMNMMHIHVFAAYFGLTVAWCLPKPLPKGTEDKYQTTTSPSLFAMLGTLFLWMFWPTFNSALLLNPIERKNAVFSTYYALAVSAVTAISVSSLAHPGGKINMTYMHNAALAGGVALSASCHVIHSPWIAMVLGLVAGLISIGGAKCLPVCFNRVLGIHESHSVHYTFGLPALLGEITYIVLMALRVVWASSNMIGFQVLLSTGTLSLAMAMSITSGLLTGLLLNLKIWKGPHVAKYFDDQAFWEFPHLAVGF
UniProt ID: Q28849
Variant: Y -> C at position 343-343
Variant annotation: in Mac-B
Protein function: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.
Reference sequence:
MSSKYPRSVRCCLPLWALTLEAALILLFFFFTYYDASLEDQKGLVASYQVCQDLTVMAVLGLGFFTSNLRRNSWSSVAFNLFLLALGVQWAILLDGFLSQFSPGKVAIKLFSIRLATRSTMSMLISMNAVLGKVNLVQLVVMELVELTVFGTMRIVINNIFKIDYGMNMMHIHVFAAYFGLTVAWCLPKPLPKGTEDKYQTTTSPSLFAMLGTLFLWMFWPTFNSALLLNPIERKNAVFSTYYALAVSAVTAISVSSLAHPGGKINMTYMHNAALAGGVALSASCHVIHSPWIAMVLGLVAGLISIGGAKCLPVCFNRVLGIHESHSVHYTFGLPALLGEITYIVLMALRVVWASSNMIGFQVLLSTGTLSLAMAMSITSGLLTGLLLNLKIWKGPHVAKYFDDQAFWEFPHLAVGF
UniProt ID: Q29429
Variant: K -> E at position 130-130
Variant annotation: in IFN-tau6A and IFN-tau6B
Protein function: Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
Reference sequence:
MAFVLSLLMALVLVSYGPGGSLGCYLSRKLMLDARENLRLLDRMNRLSPHSCLQDRKDFGLPQEMVEGDQLQKDQAFSVLYEMLQQSFNVFHTERSSAAWNTTLLEQLCTGLQQQLDHLDTCRGPVMGEKDSELGKMDPIVTVKKYFQGIHDYLQEKGYSDCAWEIVRVEMMRALTSSTTLQKRLTKTGGDLNSP
UniProt ID: Q29429
Variant: K -> N at position 136-136
Variant annotation: in IFN-tau6A, IFN-tau6B and IFN-tau6C
Protein function: Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
Reference sequence:
MAFVLSLLMALVLVSYGPGGSLGCYLSRKLMLDARENLRLLDRMNRLSPHSCLQDRKDFGLPQEMVEGDQLQKDQAFSVLYEMLQQSFNVFHTERSSAAWNTTLLEQLCTGLQQQLDHLDTCRGPVMGEKDSELGKMDPIVTVKKYFQGIHDYLQEKGYSDCAWEIVRVEMMRALTSSTTLQKRLTKTGGDLNSP
UniProt ID: Q29429
Variant: T -> M at position 188-188
Variant annotation: in IFN-tau6A
Protein function: Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
Reference sequence:
MAFVLSLLMALVLVSYGPGGSLGCYLSRKLMLDARENLRLLDRMNRLSPHSCLQDRKDFGLPQEMVEGDQLQKDQAFSVLYEMLQQSFNVFHTERSSAAWNTTLLEQLCTGLQQQLDHLDTCRGPVMGEKDSELGKMDPIVTVKKYFQGIHDYLQEKGYSDCAWEIVRVEMMRALTSSTTLQKRLTKTGGDLNSP
UniProt ID: Q29444
Variant: F -> R at position 65-65
Protein function: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
Reference sequence:
MLLRLLLLLAPCGAGFATKVVSISLRGNWKIHSGNGSLQLPATVPGCVHSALFNKRIIKDPYYRFNNLDYRWIALDNWTYIKKFKLHSDMSTWSKVNLVFEGIDTVAVVLLNSVPIGKTDNMFRRYSFDITHTVKAVNIIEVRFQSPVVYANQRSERHTAYWVPPNCPPPVQDGECHVNFIRKMQCSFGWDWGPSFPTQGIWKDVRIEAYNVCHLNYFMFTPIYDNYMKTWNLKIESSFDVVSSKLVSGEAIVAIPELNIQQTNNIELQHGERTVELFVKIDKAIIVETWWPHGHGNQTGYNMSVIFELDGGLRFEKSAKVYFRTVELVEEPIQNSPGLSFYFKINGLPIFLKGSNWIPADSFQDRVTSAMLRLLLQSVVDANMNALRVWGGGVYEQDEFYELCDELGIMIWQDFMFACALYPTDKDFMDSVREEVTHQVRRLKSHPSIITWSGNNENEAALMMGWYDTKPGYLQTYIKDYVTLYVKNIRTIVLEGDQTRPFITSSPTNGAKTIAEGWLSPNPYDLNYGDVHFYDYVSDCWNWRTFPKARFVSEYGYQSWPSFSTLEKVSSEEDWSYRSSFALHRQHLINGNNEMLHQIELHFKLPNSTDQLRRFKDTLYLTQVMQAQCVKTETEFYRRSRSEIVNGKGHTMGALYWQLNDIWQAPSWSSLEYGGKWKMLHYFARHFFAPLLPVGFEDKDMLFIYGASHLHSDQQMMLTVRVHTWSSLELVCSESTNPFVIKAGESVLLYTKPVPELLKGCPGCTRQSCVVSFYLSTDGELLSPINYHFLSSLKNAKGLHKANITATISQQGDTFVFDLKTSAVAPFVWLDVGSIPGRFSDNGFLMTEKTRTVFFYPWKPTSKSELEQSFHVTSLADTY
UniProt ID: Q29444
Variant: H -> D at position 709-709
Protein function: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
Reference sequence:
MLLRLLLLLAPCGAGFATKVVSISLRGNWKIHSGNGSLQLPATVPGCVHSALFNKRIIKDPYYRFNNLDYRWIALDNWTYIKKFKLHSDMSTWSKVNLVFEGIDTVAVVLLNSVPIGKTDNMFRRYSFDITHTVKAVNIIEVRFQSPVVYANQRSERHTAYWVPPNCPPPVQDGECHVNFIRKMQCSFGWDWGPSFPTQGIWKDVRIEAYNVCHLNYFMFTPIYDNYMKTWNLKIESSFDVVSSKLVSGEAIVAIPELNIQQTNNIELQHGERTVELFVKIDKAIIVETWWPHGHGNQTGYNMSVIFELDGGLRFEKSAKVYFRTVELVEEPIQNSPGLSFYFKINGLPIFLKGSNWIPADSFQDRVTSAMLRLLLQSVVDANMNALRVWGGGVYEQDEFYELCDELGIMIWQDFMFACALYPTDKDFMDSVREEVTHQVRRLKSHPSIITWSGNNENEAALMMGWYDTKPGYLQTYIKDYVTLYVKNIRTIVLEGDQTRPFITSSPTNGAKTIAEGWLSPNPYDLNYGDVHFYDYVSDCWNWRTFPKARFVSEYGYQSWPSFSTLEKVSSEEDWSYRSSFALHRQHLINGNNEMLHQIELHFKLPNSTDQLRRFKDTLYLTQVMQAQCVKTETEFYRRSRSEIVNGKGHTMGALYWQLNDIWQAPSWSSLEYGGKWKMLHYFARHFFAPLLPVGFEDKDMLFIYGASHLHSDQQMMLTVRVHTWSSLELVCSESTNPFVIKAGESVLLYTKPVPELLKGCPGCTRQSCVVSFYLSTDGELLSPINYHFLSSLKNAKGLHKANITATISQQGDTFVFDLKTSAVAPFVWLDVGSIPGRFSDNGFLMTEKTRTVFFYPWKPTSKSELEQSFHVTSLADTY
UniProt ID: Q29980
Variant: G -> E at position 39-39
Variant annotation: in allele MICB*001; dbSNP:rs45578846
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29980
Variant: P -> H at position 68-68
Variant annotation: in allele MICB*011; dbSNP:rs45583740
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29980
Variant: N -> D at position 75-75
Variant annotation: in allele MICB*001, allele MICB*002, allele MICB*003, allele MICB*005, allele MICB*006, allele MICB*007, allele MICB*008, allele MICB*010, allele MICB*011, allele MICB*012, allele MICB*013, allele MICB*014, allele MICB*015, allele MICB*016, allele MICB*018, allele MICB*019 and allele MICB*022; dbSNP:rs3131639
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29980
Variant: K -> E at position 80-80
Variant annotation: in allele MICB*002, allele MICB*007, allele MICB*008, allele MICB*014, allele MICB*015, allele MICB*016, allele MICB*019 and allele MICB*022; dbSNP:rs1065075
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29980
Variant: D -> G at position 88-88
Variant annotation: in allele MICB*022; dbSNP:rs45486091
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29980
Variant: D -> G at position 105-105
Variant annotation: in allele MICB*012; dbSNP:rs45502297
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29980
Variant: I -> M at position 121-121
Variant annotation: in allele MICB*008; dbSNP:rs3134900
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29980
Variant: D -> H at position 136-136
Variant annotation: in dbSNP:rs1051788
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29980
Variant: D -> N at position 136-136
Variant annotation: in allele MICB*002, allele MICB*007, allele MICB*008, allele MICB*014, allele MICB*015, allele MICB*018, allele MICB*020 and allele MICB*022; dbSNP:rs1051788
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29980
Variant: T -> I at position 212-212
Variant annotation: in allele MICB*003; dbSNP:rs41293883
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29980
Variant: E -> K at position 215-215
Variant annotation: in allele MICB*006 and allele MICB*015; dbSNP:rs45624537
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29980
Variant: R -> K at position 279-279
Variant annotation: in allele MICB*007; dbSNP:rs45587032
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29980
Variant: G -> S at position 291-291
Variant annotation: in allele MICB*013, allele MICB*014, allele MICB*015 and allele MICB*016; dbSNP:rs41273040
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29980
Variant: A -> V at position 300-300
Variant annotation: in allele MICB*001, allele MICB*016, allele MICB*018, allele MICB*019, allele MICB*020 and allele MICB*022; dbSNP:rs45470602
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29980
Variant: T -> A at position 383-383
Variant annotation: in allele MICB*001, allele MICB*002, allele MICB*005, allele MICB*006, allele MICB*007, allele MICB*008, allele MICB*012, allele MICB*013, allele MICB*014, allele MICB*015, allele MICB*016, allele MICB*018, allele MICB*019, allele MICB*020 and allele MICB*022; dbSNP:rs1065076
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGT
UniProt ID: Q29983
Variant: R -> P at position 29-29
Variant annotation: in allele MICA*010, allele MICA*025 and allele MICA*054; abolishes cell surface expression, probably by interfering with protein folding; dbSNP:rs9380254
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHRDATQLGFQPLMSDLGSTGSTEGA
UniProt ID: Q29983
Variant: W -> G at position 37-37
Variant annotation: in allele MICA*002, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*017, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*030, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*041, allele MICA*044, allele MICA*046, allele MICA*047, allele MICA*052, allele MICA*053 and allele MICA*055; dbSNP:rs1063630
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHRDATQLGFQPLMSDLGSTGSTEGA
UniProt ID: Q29983
Variant: T -> A at position 47-47
Variant annotation: in allele MICA*002, allele MICA*004, allele MICA*005, allele MICA*006, allele MICA*007, allele MICA*008, allele MICA*009, allele MICA*010, allele MICA*011, allele MICA*013, allele MICA*014, allele MICA*015, allele MICA*016, allele MICA*017, allele MICA*019, allele MICA*020, allele MICA*022, allele MICA*023, allele MICA*024, allele MICA*025, allele MICA*026, allele MICA*027, allele MICA*028, allele MICA*029, allele MICA*030, allele MICA*031, allele MICA*032, allele MICA*033, allele MICA*034, allele MICA*035, allele MICA*036, allele MICA*037, allele MICA*038, allele MICA*039, allele MICA*040, allele MICA*041, allele MICA*042, allele MICA*043, allele MICA*044, allele MICA*045, allele MICA*046, allele MICA*047, allele MICA*048, allele MICA*049, allele MICA*051, allele MICA*052, allele MICA*053, allele MICA*054, allele MICA*055 and allele MICA*056; dbSNP:rs1051785
Protein function: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Reference sequence:
MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHRDATQLGFQPLMSDLGSTGSTEGA