sujigwak/NVAR huggingface dataset:
UniProt ID: Q8SEJ1
Variant: T -> S at position 246-246
Variant annotation: in strain: Isolate CD11
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MSNLRKTHPIMKIINHTFIDLPAPSNISAWWNFGSLLGICLIMQILTGLFLAMHYTADTTTAFSSVAHICRDVNYGWLIRNLHANGASMFFMCLFLHIGRGIYYGSYLYKETWNIGVILLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGATLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVLVHLLFLHETGSNNPSGINPDSDKIPFHPYYTIKDALGLMFMLFILLLLTLFTPDMLSDPDNFSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILLAMPLLHTSNQRSMMFRPISQTLFWILTANLLILTWIGGQPVEEPYIIIGQVASISYFLLIIVLMPMAGLFENFMLKPKW
UniProt ID: Q8SEJ1
Variant: V -> A at position 353-353
Variant annotation: in strain: Isolate CD11
Protein function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Reference sequence:
MSNLRKTHPIMKIINHTFIDLPAPSNISAWWNFGSLLGICLIMQILTGLFLAMHYTADTTTAFSSVAHICRDVNYGWLIRNLHANGASMFFMCLFLHIGRGIYYGSYLYKETWNIGVILLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGATLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVLVHLLFLHETGSNNPSGINPDSDKIPFHPYYTIKDALGLMFMLFILLLLTLFTPDMLSDPDNFSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILLAMPLLHTSNQRSMMFRPISQTLFWILTANLLILTWIGGQPVEEPYIIIGQVASISYFLLIIVLMPMAGLFENFMLKPKW
UniProt ID: Q8SEL8
Variant: F -> L at position 176-176
Variant annotation: in strain: Isolate Mar AMO 01
Protein function: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.
Reference sequence:
MKEYQIHLELDRSQQHNFLYPLLFREYIYALAHDHGLNRSTIPLENGGYDNKSSSLSVKRLISRTYQRIHLSIYAKDSNPNHFIGHNNKFYSQMISEGFSVIVEIPFSLRLVAFLEGKEKEMAKSHNFQSIHSIFPFFENNFSHLHYVLDVLIPYPIRPEILVRTFRYWVKDASSFHLLRFFLHEYFNLNSLITPKKSNSIFSTSNPRFFLFLYNSHVYEYESIFFFLRNQSSHLRSTSSGPLFERISFYGKVEDLVQVFVNDFQDYLWLFKHPIMHYVRYQGKSVLASKDMPLLMNKWKYYLVNLWQWHFHVWSQPGRIHINHLYKDYIDFLGYLSRGRLNTLVVRSQMLENAFLIDNAMKQFETTVPIIPLIGSLTTARFCNSLGHPISKPTWADSSDSYIIDRFMRICRNLSHYHSGSSKKKSLYRIKYILRVSCVKSLVRKHKSTVRVFLKRLGSEFLEEFFTEEEHVLSLIFPRALFTSRRLYRGRVWYFDIICINDLVNHDKLEIVPN
UniProt ID: Q8SEL8
Variant: P -> L at position 242-242
Variant annotation: in strain: Isolate 24/2 AMO 02 and Isolate Mar AMO 01
Protein function: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.
Reference sequence:
MKEYQIHLELDRSQQHNFLYPLLFREYIYALAHDHGLNRSTIPLENGGYDNKSSSLSVKRLISRTYQRIHLSIYAKDSNPNHFIGHNNKFYSQMISEGFSVIVEIPFSLRLVAFLEGKEKEMAKSHNFQSIHSIFPFFENNFSHLHYVLDVLIPYPIRPEILVRTFRYWVKDASSFHLLRFFLHEYFNLNSLITPKKSNSIFSTSNPRFFLFLYNSHVYEYESIFFFLRNQSSHLRSTSSGPLFERISFYGKVEDLVQVFVNDFQDYLWLFKHPIMHYVRYQGKSVLASKDMPLLMNKWKYYLVNLWQWHFHVWSQPGRIHINHLYKDYIDFLGYLSRGRLNTLVVRSQMLENAFLIDNAMKQFETTVPIIPLIGSLTTARFCNSLGHPISKPTWADSSDSYIIDRFMRICRNLSHYHSGSSKKKSLYRIKYILRVSCVKSLVRKHKSTVRVFLKRLGSEFLEEFFTEEEHVLSLIFPRALFTSRRLYRGRVWYFDIICINDLVNHDKLEIVPN
UniProt ID: Q8SEL8
Variant: T -> A at position 367-367
Variant annotation: in strain: Isolate Mar AMO 01
Protein function: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.
Reference sequence:
MKEYQIHLELDRSQQHNFLYPLLFREYIYALAHDHGLNRSTIPLENGGYDNKSSSLSVKRLISRTYQRIHLSIYAKDSNPNHFIGHNNKFYSQMISEGFSVIVEIPFSLRLVAFLEGKEKEMAKSHNFQSIHSIFPFFENNFSHLHYVLDVLIPYPIRPEILVRTFRYWVKDASSFHLLRFFLHEYFNLNSLITPKKSNSIFSTSNPRFFLFLYNSHVYEYESIFFFLRNQSSHLRSTSSGPLFERISFYGKVEDLVQVFVNDFQDYLWLFKHPIMHYVRYQGKSVLASKDMPLLMNKWKYYLVNLWQWHFHVWSQPGRIHINHLYKDYIDFLGYLSRGRLNTLVVRSQMLENAFLIDNAMKQFETTVPIIPLIGSLTTARFCNSLGHPISKPTWADSSDSYIIDRFMRICRNLSHYHSGSSKKKSLYRIKYILRVSCVKSLVRKHKSTVRVFLKRLGSEFLEEFFTEEEHVLSLIFPRALFTSRRLYRGRVWYFDIICINDLVNHDKLEIVPN
UniProt ID: Q8SEL8
Variant: T -> I at position 367-367
Variant annotation: in strain: Isolate 24/2 AMO 02
Protein function: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.
Reference sequence:
MKEYQIHLELDRSQQHNFLYPLLFREYIYALAHDHGLNRSTIPLENGGYDNKSSSLSVKRLISRTYQRIHLSIYAKDSNPNHFIGHNNKFYSQMISEGFSVIVEIPFSLRLVAFLEGKEKEMAKSHNFQSIHSIFPFFENNFSHLHYVLDVLIPYPIRPEILVRTFRYWVKDASSFHLLRFFLHEYFNLNSLITPKKSNSIFSTSNPRFFLFLYNSHVYEYESIFFFLRNQSSHLRSTSSGPLFERISFYGKVEDLVQVFVNDFQDYLWLFKHPIMHYVRYQGKSVLASKDMPLLMNKWKYYLVNLWQWHFHVWSQPGRIHINHLYKDYIDFLGYLSRGRLNTLVVRSQMLENAFLIDNAMKQFETTVPIIPLIGSLTTARFCNSLGHPISKPTWADSSDSYIIDRFMRICRNLSHYHSGSSKKKSLYRIKYILRVSCVKSLVRKHKSTVRVFLKRLGSEFLEEFFTEEEHVLSLIFPRALFTSRRLYRGRVWYFDIICINDLVNHDKLEIVPN
UniProt ID: Q8SEL8
Variant: T -> M at position 467-467
Variant annotation: in strain: Isolate 24/2 AMO 02
Protein function: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.
Reference sequence:
MKEYQIHLELDRSQQHNFLYPLLFREYIYALAHDHGLNRSTIPLENGGYDNKSSSLSVKRLISRTYQRIHLSIYAKDSNPNHFIGHNNKFYSQMISEGFSVIVEIPFSLRLVAFLEGKEKEMAKSHNFQSIHSIFPFFENNFSHLHYVLDVLIPYPIRPEILVRTFRYWVKDASSFHLLRFFLHEYFNLNSLITPKKSNSIFSTSNPRFFLFLYNSHVYEYESIFFFLRNQSSHLRSTSSGPLFERISFYGKVEDLVQVFVNDFQDYLWLFKHPIMHYVRYQGKSVLASKDMPLLMNKWKYYLVNLWQWHFHVWSQPGRIHINHLYKDYIDFLGYLSRGRLNTLVVRSQMLENAFLIDNAMKQFETTVPIIPLIGSLTTARFCNSLGHPISKPTWADSSDSYIIDRFMRICRNLSHYHSGSSKKKSLYRIKYILRVSCVKSLVRKHKSTVRVFLKRLGSEFLEEFFTEEEHVLSLIFPRALFTSRRLYRGRVWYFDIICINDLVNHDKLEIVPN
UniProt ID: Q8SEL8
Variant: F -> L at position 495-495
Variant annotation: in strain: Isolate 24/2 AMO 02
Protein function: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.
Reference sequence:
MKEYQIHLELDRSQQHNFLYPLLFREYIYALAHDHGLNRSTIPLENGGYDNKSSSLSVKRLISRTYQRIHLSIYAKDSNPNHFIGHNNKFYSQMISEGFSVIVEIPFSLRLVAFLEGKEKEMAKSHNFQSIHSIFPFFENNFSHLHYVLDVLIPYPIRPEILVRTFRYWVKDASSFHLLRFFLHEYFNLNSLITPKKSNSIFSTSNPRFFLFLYNSHVYEYESIFFFLRNQSSHLRSTSSGPLFERISFYGKVEDLVQVFVNDFQDYLWLFKHPIMHYVRYQGKSVLASKDMPLLMNKWKYYLVNLWQWHFHVWSQPGRIHINHLYKDYIDFLGYLSRGRLNTLVVRSQMLENAFLIDNAMKQFETTVPIIPLIGSLTTARFCNSLGHPISKPTWADSSDSYIIDRFMRICRNLSHYHSGSSKKKSLYRIKYILRVSCVKSLVRKHKSTVRVFLKRLGSEFLEEFFTEEEHVLSLIFPRALFTSRRLYRGRVWYFDIICINDLVNHDKLEIVPN
UniProt ID: Q8SEL8
Variant: L -> F at position 509-509
Variant annotation: in strain: Isolate 24/2 AMO 02
Protein function: Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.
Reference sequence:
MKEYQIHLELDRSQQHNFLYPLLFREYIYALAHDHGLNRSTIPLENGGYDNKSSSLSVKRLISRTYQRIHLSIYAKDSNPNHFIGHNNKFYSQMISEGFSVIVEIPFSLRLVAFLEGKEKEMAKSHNFQSIHSIFPFFENNFSHLHYVLDVLIPYPIRPEILVRTFRYWVKDASSFHLLRFFLHEYFNLNSLITPKKSNSIFSTSNPRFFLFLYNSHVYEYESIFFFLRNQSSHLRSTSSGPLFERISFYGKVEDLVQVFVNDFQDYLWLFKHPIMHYVRYQGKSVLASKDMPLLMNKWKYYLVNLWQWHFHVWSQPGRIHINHLYKDYIDFLGYLSRGRLNTLVVRSQMLENAFLIDNAMKQFETTVPIIPLIGSLTTARFCNSLGHPISKPTWADSSDSYIIDRFMRICRNLSHYHSGSSKKKSLYRIKYILRVSCVKSLVRKHKSTVRVFLKRLGSEFLEEFFTEEEHVLSLIFPRALFTSRRLYRGRVWYFDIICINDLVNHDKLEIVPN
UniProt ID: Q8SEM9
Variant: V -> I at position 79-79
Variant annotation: in strain: SB146
Protein function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Reference sequence:
NNFFQGYNLLFQHSLFASYMDWFHAFNCSLLLGVLVFVTLLFGYLIFSTFYFKSKKIEYQFGELLCSIFPTIILLMQMVPSLSLLYYYGLMNLDSNLTVKVTGHQWYWSYEYSDIPGLEFDSYMKSLDQLNLGEPRLLEVDNRCVIPCDTNIRFCITSADVIHAWALNSLSVKLDAMSGILSTFSYSFPMVGVFYGQCSEICGANHSFMPIALEVTLLDNFKSWCFGTME
UniProt ID: Q8SR45
Variant: L -> F at position 288-288
Variant annotation: in strain: ATCC 50502 / ECIII
Protein function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Reference sequence:
MKCILLNQAEELPIEFLPKDGVYGKGKLFDSRNMEIENFTESDILQDARRAAEAHRRARYRVQSIVRPGITLLEIVRSIEDSTRTLLKGERNNGIGFPAGMSMNSCAAHYTVNPGEQDIVLKEDDVLKIDFGTHSDGRIMDSAFTVAFKENLEPLLVAAREGTETGIKSLGVDVRVCDIGRDINEVISSYEVEIGGRMWPIRPISDLHGHSISQFRIHGGISIPAVNNRDTTRIKGDSFYAVETFATTGKGSIDDRPPCSHFVLNTYKSRKLFNKDLIKVYEFVKDSLGTLPFSPRHLDYYGLVKGGSLKSVNLLTMMGLLTPYPPLNDIDGCKVAQFEHTVYLSEHGKEVLTRGDDY
UniProt ID: Q8SWR8
Variant: K -> R at position 381-381
Variant annotation: in RNA edited version
Protein function: RNA binding protein that regulates various processes including circadian behaviors, actin filament formation, eye development and oocyte formation . Forms a complex with tyf and pAbp which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B . Forms an activator complex (Atx2-tyf activator complex) via association with Lsm12a and activates the TYF-dependent translation of per to maintain 24 hour periodicity in circadian locomotor behaviors . Forms a repressor complex (Atx2-Not1 repressor complex) via the me31B-dependent association with Not1 to promote Not1-dependent post-transcriptional gene silencing and support high-amplitude circadian rhythms in a per-independent manner . Regulates actin filament formation, though it does not directly assemble with actin filaments . Required for oocyte specification and oocyte positioning in the female germline . Also required for normal eye development and bristle morphology .
Reference sequence:
MNNNSKRKTRPTGGGASGGISRYNSNDNSLRPTNNKAGAGGGNGGAAVRPSAQGVYNNTFFMHSATALVGSVVEVRLRSGNIYEGVFRTFSGNFDIALELPACIKSKNLPEEGKVPKHIIFPADTVVTIVAKDFDSQYATAGAFQTDGAISDKCNGARPDEKELEPWDSGANGDIDIELDSAANGWDPNEMFRKNENTFGVTSTFDDSLASYTVPLDKGDSLEFKEAEAKAEKLAAEIENNPTCRDRLDLENGDEEALFAAVERPSTEQDQRGDRGDRERNDRDREREERDRDRDRDRGNKPRGAGDFQLRETMSSDRYITKQTRSITGPQLSHVGMSSQGSGRDRDTRGDGSMMMQSGGGSGQGGSTQSTAALMLAGGLKGVGPAPSANASADSSSKYSGGSMVKRKTVPQGGKVMRNNVPTGGSNVSVSQGGNGNSVGQNKGGYQPSMGMPSQYSYQGNSQIMHGSSQYRNQSHMGGANKLNGDSNANTNKPLPQRQMRQYQGSQSNSSLNYGGEPQSLGKPVHGSHGGHPGQNSNSPPLQTAGPQQQQQQQQQQQQQQQQQQPPQQQQHQNIQPQGQNTQPARQVRTRDNQMQELRQFGQDFQLAPSNTSPPQQQQQQQQQQQQHQVQQQQQRALQQSASPPQQQQQQQQQQQHVVLHQVPQTHLHQAALSQPHYVPQQQPQQAPLPQQQHVPHHMQQKAQQQQLVETQHQHVQKQHQSQPQVQQPPPQLLQDPSQQPLPIYHTMPPPQTSPVVVTSPVLLEQPPPQPMPVVQQQQTQQLATPKPEVSPAPPSSNTTTPTGIASTPTAGVIASAGSEKTTPAAPTPTSNSATVPTGTAATAGGATGTTPVVKKHVLNPSAKPFTPRGPSTPNPSRPHTPQTPVPMTNIYTTTGGHVPPAANQPIYVMQPQHPFPPQTHPQAGQPPRLRRSNYPPMAASQMHVSASAATGQPLITAGPIPQFIQYGHAPHQQQFQSHTYAPMQMRVYPDQPQQLQFMTQTPQSTTPSPGQPHQQFHPPPQPSPAGGGPQPAFTPPTQAATYQLMCVHPQSLLANHYFPPPTPQHPQQNQQQYQIVMQQHQPQ
UniProt ID: Q8SWR8
Variant: K -> R at position 398-398
Variant annotation: in RNA edited version
Protein function: RNA binding protein that regulates various processes including circadian behaviors, actin filament formation, eye development and oocyte formation . Forms a complex with tyf and pAbp which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B . Forms an activator complex (Atx2-tyf activator complex) via association with Lsm12a and activates the TYF-dependent translation of per to maintain 24 hour periodicity in circadian locomotor behaviors . Forms a repressor complex (Atx2-Not1 repressor complex) via the me31B-dependent association with Not1 to promote Not1-dependent post-transcriptional gene silencing and support high-amplitude circadian rhythms in a per-independent manner . Regulates actin filament formation, though it does not directly assemble with actin filaments . Required for oocyte specification and oocyte positioning in the female germline . Also required for normal eye development and bristle morphology .
Reference sequence:
MNNNSKRKTRPTGGGASGGISRYNSNDNSLRPTNNKAGAGGGNGGAAVRPSAQGVYNNTFFMHSATALVGSVVEVRLRSGNIYEGVFRTFSGNFDIALELPACIKSKNLPEEGKVPKHIIFPADTVVTIVAKDFDSQYATAGAFQTDGAISDKCNGARPDEKELEPWDSGANGDIDIELDSAANGWDPNEMFRKNENTFGVTSTFDDSLASYTVPLDKGDSLEFKEAEAKAEKLAAEIENNPTCRDRLDLENGDEEALFAAVERPSTEQDQRGDRGDRERNDRDREREERDRDRDRDRGNKPRGAGDFQLRETMSSDRYITKQTRSITGPQLSHVGMSSQGSGRDRDTRGDGSMMMQSGGGSGQGGSTQSTAALMLAGGLKGVGPAPSANASADSSSKYSGGSMVKRKTVPQGGKVMRNNVPTGGSNVSVSQGGNGNSVGQNKGGYQPSMGMPSQYSYQGNSQIMHGSSQYRNQSHMGGANKLNGDSNANTNKPLPQRQMRQYQGSQSNSSLNYGGEPQSLGKPVHGSHGGHPGQNSNSPPLQTAGPQQQQQQQQQQQQQQQQQQPPQQQQHQNIQPQGQNTQPARQVRTRDNQMQELRQFGQDFQLAPSNTSPPQQQQQQQQQQQQHQVQQQQQRALQQSASPPQQQQQQQQQQQHVVLHQVPQTHLHQAALSQPHYVPQQQPQQAPLPQQQHVPHHMQQKAQQQQLVETQHQHVQKQHQSQPQVQQPPPQLLQDPSQQPLPIYHTMPPPQTSPVVVTSPVLLEQPPPQPMPVVQQQQTQQLATPKPEVSPAPPSSNTTTPTGIASTPTAGVIASAGSEKTTPAAPTPTSNSATVPTGTAATAGGATGTTPVVKKHVLNPSAKPFTPRGPSTPNPSRPHTPQTPVPMTNIYTTTGGHVPPAANQPIYVMQPQHPFPPQTHPQAGQPPRLRRSNYPPMAASQMHVSASAATGQPLITAGPIPQFIQYGHAPHQQQFQSHTYAPMQMRVYPDQPQQLQFMTQTPQSTTPSPGQPHQQFHPPPQPSPAGGGPQPAFTPPTQAATYQLMCVHPQSLLANHYFPPPTPQHPQQNQQQYQIVMQQHQPQ
UniProt ID: Q8SXY6
Variant: C -> S at position 14-14
Variant annotation: in strain: ZBMEL131
Protein function: Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected.
Reference sequence:
MARAAFIVCLLMACAWSSHAVMFKLSPNTQKCLKEDIQANQLVMGEFEVSDVPGQIIDYIARDTKGHILSQKEHITKGKFSFMSEVYDTYEICFISKVPAHQRGVIQEVSLLTKKGVETKSYEGIGEASKLKPLEVDLKRLEDLSDSIVRDFVLMRKREEEMRDTNEKTNSRVLFFSIFSMCCLLGLATWQVLYLRRYFKAKKLIE
UniProt ID: Q8SXY6
Variant: I -> V at position 60-60
Variant annotation: in strain: MEL18 and MEL20
Protein function: Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected.
Reference sequence:
MARAAFIVCLLMACAWSSHAVMFKLSPNTQKCLKEDIQANQLVMGEFEVSDVPGQIIDYIARDTKGHILSQKEHITKGKFSFMSEVYDTYEICFISKVPAHQRGVIQEVSLLTKKGVETKSYEGIGEASKLKPLEVDLKRLEDLSDSIVRDFVLMRKREEEMRDTNEKTNSRVLFFSIFSMCCLLGLATWQVLYLRRYFKAKKLIE
UniProt ID: Q8SXY6
Variant: I -> T at position 95-95
Variant annotation: in strain: ZBMEL82
Protein function: Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected.
Reference sequence:
MARAAFIVCLLMACAWSSHAVMFKLSPNTQKCLKEDIQANQLVMGEFEVSDVPGQIIDYIARDTKGHILSQKEHITKGKFSFMSEVYDTYEICFISKVPAHQRGVIQEVSLLTKKGVETKSYEGIGEASKLKPLEVDLKRLEDLSDSIVRDFVLMRKREEEMRDTNEKTNSRVLFFSIFSMCCLLGLATWQVLYLRRYFKAKKLIE
UniProt ID: Q8SXY6
Variant: I -> V at position 106-106
Variant annotation: in strain: MEL11, MEL12, ZBMEL82, ZBMEL131, ZBMEL186, ZBMEL191 and ZBMEL229
Protein function: Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected.
Reference sequence:
MARAAFIVCLLMACAWSSHAVMFKLSPNTQKCLKEDIQANQLVMGEFEVSDVPGQIIDYIARDTKGHILSQKEHITKGKFSFMSEVYDTYEICFISKVPAHQRGVIQEVSLLTKKGVETKSYEGIGEASKLKPLEVDLKRLEDLSDSIVRDFVLMRKREEEMRDTNEKTNSRVLFFSIFSMCCLLGLATWQVLYLRRYFKAKKLIE
UniProt ID: Q8T626
Variant: P -> T at position 136-136
Variant annotation: in strain: Oregon-R
Protein function: Regulator of cell proliferation and cell survival of differentiated cells independent of cell division. Essential for imaginal disks formation. Not involved in cell polarity.
Reference sequence:
MTAELKASDTEMTKPEERHLLQLLAQLEKVPHHQLEQKFVAYFKKVGKGDNQSNCTLEDFATYFLGALRQSTKRYYYSQNSETPVFPLTPIHQLKPPVADVVKEEEQQQLNESSILSRSSCSMSSTSNTTPAPQQPQGRRSTPGSGAQFCSTPNRSGGGGAGGGHSICLGNFLVNTPIQSHQRSKKKITPQKQQQNQHASLGSGTGAGATPQSKPRRRVLPMTISKNVSASSSFGDTSSFSNENNFWRISQSSEIFDRSQEAALEMEARKFLLLKKQEIKSEAPVNVSQQERTPEDEVFPEEAISLEGVANANHLQLLSTIYSLLMDLNLVPNVLRELSFVVHLLNVRDFGQSPVKSYVPSALEGLTQHKSCVYFAAKLLENQKKLLLQLDKRTLSVLLQNERLSLLPQGVVQELETHCQRRQDSTTPFAMDTSSSSQQNVYYHVENDSRDNFPSQNEFGAFKSQRDLFYKALKRWEVSHLNRGFNFPSELGPRIMDIYKKSEHPVNMTHLAKLFVNQLLISATETTESPEELGLKLDPLRHNKLAQRLVTSSSSVEGQFPRSQAFFRDFIAVCSSVAFLVHLKLELFVQLMRNNDSTFDLLQLTDDVAVEEQSAQQGPYIVRVQTMANMLILAKFLGYVTVMPFSGTTQHGNPTPPYLCPQQLQLRNHFRPDFNLREILERSMRQGKLLITLPWLVQYLAMLDLVSLHLPDAVATLELLYGLYADIRMAKLQPAAVFIARSCIGWLLDAQPQLVNGYYNYRAQEAGVGSISAIVDICLKDLSCHDKSHAPLLDELLPVACPFLQEFRVSITPSRQAKSGRFRYITTRLEQLQQNSSSISKDAIVASELSPAEQQQRKLVDAYLQSQNASTRRLIEFVTERTFKCVVKDAQQEILLPSKASADAKVNEIKSTMLEEVFQELHEIFQDARENACQRWKEHVHQMLDRRIEHSLDGLLPSSTNAVLRSTYAHLIRVQAQTQLQQWLQSSVLQSTFYHGDLQELATKVCNCNRNKADAAAAGGGGSSELQLSPDIGFSLSEFLYQLQQWLHCLSLRPEYVGSQEDLAELLRKAQKAVLLPKMPTVFYHLIGSGLVHLLQLLITRKPNFLDKDIISASCSVWRSQQLMDSKASPGIFDGLISISFVQEMANSADSFRMLETILRSMLQSGAIRADHLNELFMPLFAENWSPKVWCMLSELLQQLSLSGKDSEAHYASGDSPEDEAKSHLFMEMLADLSRDLDNF
UniProt ID: Q8T626
Variant: A -> V at position 209-209
Variant annotation: in strain: Oregon-R
Protein function: Regulator of cell proliferation and cell survival of differentiated cells independent of cell division. Essential for imaginal disks formation. Not involved in cell polarity.
Reference sequence:
MTAELKASDTEMTKPEERHLLQLLAQLEKVPHHQLEQKFVAYFKKVGKGDNQSNCTLEDFATYFLGALRQSTKRYYYSQNSETPVFPLTPIHQLKPPVADVVKEEEQQQLNESSILSRSSCSMSSTSNTTPAPQQPQGRRSTPGSGAQFCSTPNRSGGGGAGGGHSICLGNFLVNTPIQSHQRSKKKITPQKQQQNQHASLGSGTGAGATPQSKPRRRVLPMTISKNVSASSSFGDTSSFSNENNFWRISQSSEIFDRSQEAALEMEARKFLLLKKQEIKSEAPVNVSQQERTPEDEVFPEEAISLEGVANANHLQLLSTIYSLLMDLNLVPNVLRELSFVVHLLNVRDFGQSPVKSYVPSALEGLTQHKSCVYFAAKLLENQKKLLLQLDKRTLSVLLQNERLSLLPQGVVQELETHCQRRQDSTTPFAMDTSSSSQQNVYYHVENDSRDNFPSQNEFGAFKSQRDLFYKALKRWEVSHLNRGFNFPSELGPRIMDIYKKSEHPVNMTHLAKLFVNQLLISATETTESPEELGLKLDPLRHNKLAQRLVTSSSSVEGQFPRSQAFFRDFIAVCSSVAFLVHLKLELFVQLMRNNDSTFDLLQLTDDVAVEEQSAQQGPYIVRVQTMANMLILAKFLGYVTVMPFSGTTQHGNPTPPYLCPQQLQLRNHFRPDFNLREILERSMRQGKLLITLPWLVQYLAMLDLVSLHLPDAVATLELLYGLYADIRMAKLQPAAVFIARSCIGWLLDAQPQLVNGYYNYRAQEAGVGSISAIVDICLKDLSCHDKSHAPLLDELLPVACPFLQEFRVSITPSRQAKSGRFRYITTRLEQLQQNSSSISKDAIVASELSPAEQQQRKLVDAYLQSQNASTRRLIEFVTERTFKCVVKDAQQEILLPSKASADAKVNEIKSTMLEEVFQELHEIFQDARENACQRWKEHVHQMLDRRIEHSLDGLLPSSTNAVLRSTYAHLIRVQAQTQLQQWLQSSVLQSTFYHGDLQELATKVCNCNRNKADAAAAGGGGSSELQLSPDIGFSLSEFLYQLQQWLHCLSLRPEYVGSQEDLAELLRKAQKAVLLPKMPTVFYHLIGSGLVHLLQLLITRKPNFLDKDIISASCSVWRSQQLMDSKASPGIFDGLISISFVQEMANSADSFRMLETILRSMLQSGAIRADHLNELFMPLFAENWSPKVWCMLSELLQQLSLSGKDSEAHYASGDSPEDEAKSHLFMEMLADLSRDLDNF
UniProt ID: Q8T626
Variant: Y -> C at position 358-358
Variant annotation: in strain: Oregon-R
Protein function: Regulator of cell proliferation and cell survival of differentiated cells independent of cell division. Essential for imaginal disks formation. Not involved in cell polarity.
Reference sequence:
MTAELKASDTEMTKPEERHLLQLLAQLEKVPHHQLEQKFVAYFKKVGKGDNQSNCTLEDFATYFLGALRQSTKRYYYSQNSETPVFPLTPIHQLKPPVADVVKEEEQQQLNESSILSRSSCSMSSTSNTTPAPQQPQGRRSTPGSGAQFCSTPNRSGGGGAGGGHSICLGNFLVNTPIQSHQRSKKKITPQKQQQNQHASLGSGTGAGATPQSKPRRRVLPMTISKNVSASSSFGDTSSFSNENNFWRISQSSEIFDRSQEAALEMEARKFLLLKKQEIKSEAPVNVSQQERTPEDEVFPEEAISLEGVANANHLQLLSTIYSLLMDLNLVPNVLRELSFVVHLLNVRDFGQSPVKSYVPSALEGLTQHKSCVYFAAKLLENQKKLLLQLDKRTLSVLLQNERLSLLPQGVVQELETHCQRRQDSTTPFAMDTSSSSQQNVYYHVENDSRDNFPSQNEFGAFKSQRDLFYKALKRWEVSHLNRGFNFPSELGPRIMDIYKKSEHPVNMTHLAKLFVNQLLISATETTESPEELGLKLDPLRHNKLAQRLVTSSSSVEGQFPRSQAFFRDFIAVCSSVAFLVHLKLELFVQLMRNNDSTFDLLQLTDDVAVEEQSAQQGPYIVRVQTMANMLILAKFLGYVTVMPFSGTTQHGNPTPPYLCPQQLQLRNHFRPDFNLREILERSMRQGKLLITLPWLVQYLAMLDLVSLHLPDAVATLELLYGLYADIRMAKLQPAAVFIARSCIGWLLDAQPQLVNGYYNYRAQEAGVGSISAIVDICLKDLSCHDKSHAPLLDELLPVACPFLQEFRVSITPSRQAKSGRFRYITTRLEQLQQNSSSISKDAIVASELSPAEQQQRKLVDAYLQSQNASTRRLIEFVTERTFKCVVKDAQQEILLPSKASADAKVNEIKSTMLEEVFQELHEIFQDARENACQRWKEHVHQMLDRRIEHSLDGLLPSSTNAVLRSTYAHLIRVQAQTQLQQWLQSSVLQSTFYHGDLQELATKVCNCNRNKADAAAAGGGGSSELQLSPDIGFSLSEFLYQLQQWLHCLSLRPEYVGSQEDLAELLRKAQKAVLLPKMPTVFYHLIGSGLVHLLQLLITRKPNFLDKDIISASCSVWRSQQLMDSKASPGIFDGLISISFVQEMANSADSFRMLETILRSMLQSGAIRADHLNELFMPLFAENWSPKVWCMLSELLQQLSLSGKDSEAHYASGDSPEDEAKSHLFMEMLADLSRDLDNF
UniProt ID: Q8T626
Variant: V -> I at position 411-411
Variant annotation: in strain: 2b
Protein function: Regulator of cell proliferation and cell survival of differentiated cells independent of cell division. Essential for imaginal disks formation. Not involved in cell polarity.
Reference sequence:
MTAELKASDTEMTKPEERHLLQLLAQLEKVPHHQLEQKFVAYFKKVGKGDNQSNCTLEDFATYFLGALRQSTKRYYYSQNSETPVFPLTPIHQLKPPVADVVKEEEQQQLNESSILSRSSCSMSSTSNTTPAPQQPQGRRSTPGSGAQFCSTPNRSGGGGAGGGHSICLGNFLVNTPIQSHQRSKKKITPQKQQQNQHASLGSGTGAGATPQSKPRRRVLPMTISKNVSASSSFGDTSSFSNENNFWRISQSSEIFDRSQEAALEMEARKFLLLKKQEIKSEAPVNVSQQERTPEDEVFPEEAISLEGVANANHLQLLSTIYSLLMDLNLVPNVLRELSFVVHLLNVRDFGQSPVKSYVPSALEGLTQHKSCVYFAAKLLENQKKLLLQLDKRTLSVLLQNERLSLLPQGVVQELETHCQRRQDSTTPFAMDTSSSSQQNVYYHVENDSRDNFPSQNEFGAFKSQRDLFYKALKRWEVSHLNRGFNFPSELGPRIMDIYKKSEHPVNMTHLAKLFVNQLLISATETTESPEELGLKLDPLRHNKLAQRLVTSSSSVEGQFPRSQAFFRDFIAVCSSVAFLVHLKLELFVQLMRNNDSTFDLLQLTDDVAVEEQSAQQGPYIVRVQTMANMLILAKFLGYVTVMPFSGTTQHGNPTPPYLCPQQLQLRNHFRPDFNLREILERSMRQGKLLITLPWLVQYLAMLDLVSLHLPDAVATLELLYGLYADIRMAKLQPAAVFIARSCIGWLLDAQPQLVNGYYNYRAQEAGVGSISAIVDICLKDLSCHDKSHAPLLDELLPVACPFLQEFRVSITPSRQAKSGRFRYITTRLEQLQQNSSSISKDAIVASELSPAEQQQRKLVDAYLQSQNASTRRLIEFVTERTFKCVVKDAQQEILLPSKASADAKVNEIKSTMLEEVFQELHEIFQDARENACQRWKEHVHQMLDRRIEHSLDGLLPSSTNAVLRSTYAHLIRVQAQTQLQQWLQSSVLQSTFYHGDLQELATKVCNCNRNKADAAAAGGGGSSELQLSPDIGFSLSEFLYQLQQWLHCLSLRPEYVGSQEDLAELLRKAQKAVLLPKMPTVFYHLIGSGLVHLLQLLITRKPNFLDKDIISASCSVWRSQQLMDSKASPGIFDGLISISFVQEMANSADSFRMLETILRSMLQSGAIRADHLNELFMPLFAENWSPKVWCMLSELLQQLSLSGKDSEAHYASGDSPEDEAKSHLFMEMLADLSRDLDNF
UniProt ID: Q8T626
Variant: H -> Y at position 418-418
Variant annotation: in strain: 2b
Protein function: Regulator of cell proliferation and cell survival of differentiated cells independent of cell division. Essential for imaginal disks formation. Not involved in cell polarity.
Reference sequence:
MTAELKASDTEMTKPEERHLLQLLAQLEKVPHHQLEQKFVAYFKKVGKGDNQSNCTLEDFATYFLGALRQSTKRYYYSQNSETPVFPLTPIHQLKPPVADVVKEEEQQQLNESSILSRSSCSMSSTSNTTPAPQQPQGRRSTPGSGAQFCSTPNRSGGGGAGGGHSICLGNFLVNTPIQSHQRSKKKITPQKQQQNQHASLGSGTGAGATPQSKPRRRVLPMTISKNVSASSSFGDTSSFSNENNFWRISQSSEIFDRSQEAALEMEARKFLLLKKQEIKSEAPVNVSQQERTPEDEVFPEEAISLEGVANANHLQLLSTIYSLLMDLNLVPNVLRELSFVVHLLNVRDFGQSPVKSYVPSALEGLTQHKSCVYFAAKLLENQKKLLLQLDKRTLSVLLQNERLSLLPQGVVQELETHCQRRQDSTTPFAMDTSSSSQQNVYYHVENDSRDNFPSQNEFGAFKSQRDLFYKALKRWEVSHLNRGFNFPSELGPRIMDIYKKSEHPVNMTHLAKLFVNQLLISATETTESPEELGLKLDPLRHNKLAQRLVTSSSSVEGQFPRSQAFFRDFIAVCSSVAFLVHLKLELFVQLMRNNDSTFDLLQLTDDVAVEEQSAQQGPYIVRVQTMANMLILAKFLGYVTVMPFSGTTQHGNPTPPYLCPQQLQLRNHFRPDFNLREILERSMRQGKLLITLPWLVQYLAMLDLVSLHLPDAVATLELLYGLYADIRMAKLQPAAVFIARSCIGWLLDAQPQLVNGYYNYRAQEAGVGSISAIVDICLKDLSCHDKSHAPLLDELLPVACPFLQEFRVSITPSRQAKSGRFRYITTRLEQLQQNSSSISKDAIVASELSPAEQQQRKLVDAYLQSQNASTRRLIEFVTERTFKCVVKDAQQEILLPSKASADAKVNEIKSTMLEEVFQELHEIFQDARENACQRWKEHVHQMLDRRIEHSLDGLLPSSTNAVLRSTYAHLIRVQAQTQLQQWLQSSVLQSTFYHGDLQELATKVCNCNRNKADAAAAGGGGSSELQLSPDIGFSLSEFLYQLQQWLHCLSLRPEYVGSQEDLAELLRKAQKAVLLPKMPTVFYHLIGSGLVHLLQLLITRKPNFLDKDIISASCSVWRSQQLMDSKASPGIFDGLISISFVQEMANSADSFRMLETILRSMLQSGAIRADHLNELFMPLFAENWSPKVWCMLSELLQQLSLSGKDSEAHYASGDSPEDEAKSHLFMEMLADLSRDLDNF