sujigwak/NVAR huggingface dataset:
UniProt ID: Q59L12
Variant: S -> P at position 843-843
Variant annotation: in allele ALS3-1
Protein function: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys.
Reference sequence:
MLQQYTLLLIYLSVATAKTITGVFNSFNSLTWSNAATYNYKGPGTPTWNAVLGWSLDGTSASPGDTFTLNMPCVFKFTTSQTSVDLTAHGVKYATCQFQAGEEFMTFSTLTCTVSNTLTPSIKALGTVTLPLAFNVGGTGSSVDLEDSKCFTAGTNTVTFNDGGKKISINVDFERSNVDPKGYLTDSRVIPSLNKVSTLFVAPQCANGYTSGTMGFANTYGDVQIDCSNIHVGITKGLNDWNYPVSSESFSYTKTCSSNGIFITYKNVPAGYRPFVDAYISATDVNSYTLSYANEYTCAGGYWQRAPFTLRWTGYRNSDAGSNGIVIVATTRTVTDSTTAVTTLPFDPNRDKTKTIEILKPIPTTTITTSYVGVTTSYSTKTAPIGETATVIVDIPYHTTTTVTSKWTGTITSTTTHTNPTDSIDTVIVQVPSPNPTVTTTEYWSQSFATTTTITGPPGNTDTVLIREPPNHTVTTTEYWSESYTTTSTFTAPPGGTDSVIIKEPPNPTVTTTEYWSESYTTTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSYTTTTTVIAPPGGTDSVIIREPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYTTTTTVIAPPGGTDSVIIKEPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSFATTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSFATTTTIIAPPGETDTVLIREPPNPTVTTTEYWSQSYTTATTVTAPPGGTDTVIIYDTMSSSEISSFSRPHYTNHTTLWSTTWVIETKTITETSCEGDKGCSWVSVSTRIVTIPNNIETPMVTNTVDTTTTESTLQSPSGIFSESGVSVETESSTFTTAQTNPSVPTTESEVVFTTKGNNGNGPYESPSTNVKSSMDENSEFTTSTAASTSTDIENETIATTGSVEASSPIISSSADETTTVTTTAESTSVIEQQTNNNGGGNAPSATSTSSPSTTTTANSDSVITSTTSTNQSQSQSNSDTQQTTLSQQMTSSLVSLHMLTTFDGSGSVIQHSTWLCGLITLLSLFI
UniProt ID: Q59L12
Variant: A -> T at position 847-847
Variant annotation: in allele ALS3-1
Protein function: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys.
Reference sequence:
MLQQYTLLLIYLSVATAKTITGVFNSFNSLTWSNAATYNYKGPGTPTWNAVLGWSLDGTSASPGDTFTLNMPCVFKFTTSQTSVDLTAHGVKYATCQFQAGEEFMTFSTLTCTVSNTLTPSIKALGTVTLPLAFNVGGTGSSVDLEDSKCFTAGTNTVTFNDGGKKISINVDFERSNVDPKGYLTDSRVIPSLNKVSTLFVAPQCANGYTSGTMGFANTYGDVQIDCSNIHVGITKGLNDWNYPVSSESFSYTKTCSSNGIFITYKNVPAGYRPFVDAYISATDVNSYTLSYANEYTCAGGYWQRAPFTLRWTGYRNSDAGSNGIVIVATTRTVTDSTTAVTTLPFDPNRDKTKTIEILKPIPTTTITTSYVGVTTSYSTKTAPIGETATVIVDIPYHTTTTVTSKWTGTITSTTTHTNPTDSIDTVIVQVPSPNPTVTTTEYWSQSFATTTTITGPPGNTDTVLIREPPNHTVTTTEYWSESYTTTSTFTAPPGGTDSVIIKEPPNPTVTTTEYWSESYTTTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSYTTTTTVIAPPGGTDSVIIREPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYTTTTTVIAPPGGTDSVIIKEPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSFATTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSFATTTTIIAPPGETDTVLIREPPNPTVTTTEYWSQSYTTATTVTAPPGGTDTVIIYDTMSSSEISSFSRPHYTNHTTLWSTTWVIETKTITETSCEGDKGCSWVSVSTRIVTIPNNIETPMVTNTVDTTTTESTLQSPSGIFSESGVSVETESSTFTTAQTNPSVPTTESEVVFTTKGNNGNGPYESPSTNVKSSMDENSEFTTSTAASTSTDIENETIATTGSVEASSPIISSSADETTTVTTTAESTSVIEQQTNNNGGGNAPSATSTSSPSTTTTANSDSVITSTTSTNQSQSQSNSDTQQTTLSQQMTSSLVSLHMLTTFDGSGSVIQHSTWLCGLITLLSLFI
UniProt ID: Q59L12
Variant: T -> I at position 851-851
Variant annotation: in allele ALS3-1
Protein function: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys.
Reference sequence:
MLQQYTLLLIYLSVATAKTITGVFNSFNSLTWSNAATYNYKGPGTPTWNAVLGWSLDGTSASPGDTFTLNMPCVFKFTTSQTSVDLTAHGVKYATCQFQAGEEFMTFSTLTCTVSNTLTPSIKALGTVTLPLAFNVGGTGSSVDLEDSKCFTAGTNTVTFNDGGKKISINVDFERSNVDPKGYLTDSRVIPSLNKVSTLFVAPQCANGYTSGTMGFANTYGDVQIDCSNIHVGITKGLNDWNYPVSSESFSYTKTCSSNGIFITYKNVPAGYRPFVDAYISATDVNSYTLSYANEYTCAGGYWQRAPFTLRWTGYRNSDAGSNGIVIVATTRTVTDSTTAVTTLPFDPNRDKTKTIEILKPIPTTTITTSYVGVTTSYSTKTAPIGETATVIVDIPYHTTTTVTSKWTGTITSTTTHTNPTDSIDTVIVQVPSPNPTVTTTEYWSQSFATTTTITGPPGNTDTVLIREPPNHTVTTTEYWSESYTTTSTFTAPPGGTDSVIIKEPPNPTVTTTEYWSESYTTTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSYTTTTTVIAPPGGTDSVIIREPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYTTTTTVIAPPGGTDSVIIKEPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSFATTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSFATTTTIIAPPGETDTVLIREPPNPTVTTTEYWSQSYTTATTVTAPPGGTDTVIIYDTMSSSEISSFSRPHYTNHTTLWSTTWVIETKTITETSCEGDKGCSWVSVSTRIVTIPNNIETPMVTNTVDTTTTESTLQSPSGIFSESGVSVETESSTFTTAQTNPSVPTTESEVVFTTKGNNGNGPYESPSTNVKSSMDENSEFTTSTAASTSTDIENETIATTGSVEASSPIISSSADETTTVTTTAESTSVIEQQTNNNGGGNAPSATSTSSPSTTTTANSDSVITSTTSTNQSQSQSNSDTQQTTLSQQMTSSLVSLHMLTTFDGSGSVIQHSTWLCGLITLLSLFI
UniProt ID: Q59L12
Variant: T -> S at position 935-935
Variant annotation: in allele ALS3-1
Protein function: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys.
Reference sequence:
MLQQYTLLLIYLSVATAKTITGVFNSFNSLTWSNAATYNYKGPGTPTWNAVLGWSLDGTSASPGDTFTLNMPCVFKFTTSQTSVDLTAHGVKYATCQFQAGEEFMTFSTLTCTVSNTLTPSIKALGTVTLPLAFNVGGTGSSVDLEDSKCFTAGTNTVTFNDGGKKISINVDFERSNVDPKGYLTDSRVIPSLNKVSTLFVAPQCANGYTSGTMGFANTYGDVQIDCSNIHVGITKGLNDWNYPVSSESFSYTKTCSSNGIFITYKNVPAGYRPFVDAYISATDVNSYTLSYANEYTCAGGYWQRAPFTLRWTGYRNSDAGSNGIVIVATTRTVTDSTTAVTTLPFDPNRDKTKTIEILKPIPTTTITTSYVGVTTSYSTKTAPIGETATVIVDIPYHTTTTVTSKWTGTITSTTTHTNPTDSIDTVIVQVPSPNPTVTTTEYWSQSFATTTTITGPPGNTDTVLIREPPNHTVTTTEYWSESYTTTSTFTAPPGGTDSVIIKEPPNPTVTTTEYWSESYTTTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSYTTTTTVIAPPGGTDSVIIREPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYTTTTTVIAPPGGTDSVIIKEPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSFATTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSFATTTTIIAPPGETDTVLIREPPNPTVTTTEYWSQSYTTATTVTAPPGGTDTVIIYDTMSSSEISSFSRPHYTNHTTLWSTTWVIETKTITETSCEGDKGCSWVSVSTRIVTIPNNIETPMVTNTVDTTTTESTLQSPSGIFSESGVSVETESSTFTTAQTNPSVPTTESEVVFTTKGNNGNGPYESPSTNVKSSMDENSEFTTSTAASTSTDIENETIATTGSVEASSPIISSSADETTTVTTTAESTSVIEQQTNNNGGGNAPSATSTSSPSTTTTANSDSVITSTTSTNQSQSQSNSDTQQTTLSQQMTSSLVSLHMLTTFDGSGSVIQHSTWLCGLITLLSLFI
UniProt ID: Q59L12
Variant: F -> V at position 963-963
Variant annotation: in allele ALS3-1
Protein function: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys.
Reference sequence:
MLQQYTLLLIYLSVATAKTITGVFNSFNSLTWSNAATYNYKGPGTPTWNAVLGWSLDGTSASPGDTFTLNMPCVFKFTTSQTSVDLTAHGVKYATCQFQAGEEFMTFSTLTCTVSNTLTPSIKALGTVTLPLAFNVGGTGSSVDLEDSKCFTAGTNTVTFNDGGKKISINVDFERSNVDPKGYLTDSRVIPSLNKVSTLFVAPQCANGYTSGTMGFANTYGDVQIDCSNIHVGITKGLNDWNYPVSSESFSYTKTCSSNGIFITYKNVPAGYRPFVDAYISATDVNSYTLSYANEYTCAGGYWQRAPFTLRWTGYRNSDAGSNGIVIVATTRTVTDSTTAVTTLPFDPNRDKTKTIEILKPIPTTTITTSYVGVTTSYSTKTAPIGETATVIVDIPYHTTTTVTSKWTGTITSTTTHTNPTDSIDTVIVQVPSPNPTVTTTEYWSQSFATTTTITGPPGNTDTVLIREPPNHTVTTTEYWSESYTTTSTFTAPPGGTDSVIIKEPPNPTVTTTEYWSESYTTTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSYTTTTTVIAPPGGTDSVIIREPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYTTTTTVIAPPGGTDSVIIKEPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSFATTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSFATTTTIIAPPGETDTVLIREPPNPTVTTTEYWSQSYTTATTVTAPPGGTDTVIIYDTMSSSEISSFSRPHYTNHTTLWSTTWVIETKTITETSCEGDKGCSWVSVSTRIVTIPNNIETPMVTNTVDTTTTESTLQSPSGIFSESGVSVETESSTFTTAQTNPSVPTTESEVVFTTKGNNGNGPYESPSTNVKSSMDENSEFTTSTAASTSTDIENETIATTGSVEASSPIISSSADETTTVTTTAESTSVIEQQTNNNGGGNAPSATSTSSPSTTTTANSDSVITSTTSTNQSQSQSNSDTQQTTLSQQMTSSLVSLHMLTTFDGSGSVIQHSTWLCGLITLLSLFI
UniProt ID: Q59L12
Variant: Q -> P at position 1062-1062
Variant annotation: in allele ALS3-1
Protein function: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys.
Reference sequence:
MLQQYTLLLIYLSVATAKTITGVFNSFNSLTWSNAATYNYKGPGTPTWNAVLGWSLDGTSASPGDTFTLNMPCVFKFTTSQTSVDLTAHGVKYATCQFQAGEEFMTFSTLTCTVSNTLTPSIKALGTVTLPLAFNVGGTGSSVDLEDSKCFTAGTNTVTFNDGGKKISINVDFERSNVDPKGYLTDSRVIPSLNKVSTLFVAPQCANGYTSGTMGFANTYGDVQIDCSNIHVGITKGLNDWNYPVSSESFSYTKTCSSNGIFITYKNVPAGYRPFVDAYISATDVNSYTLSYANEYTCAGGYWQRAPFTLRWTGYRNSDAGSNGIVIVATTRTVTDSTTAVTTLPFDPNRDKTKTIEILKPIPTTTITTSYVGVTTSYSTKTAPIGETATVIVDIPYHTTTTVTSKWTGTITSTTTHTNPTDSIDTVIVQVPSPNPTVTTTEYWSQSFATTTTITGPPGNTDTVLIREPPNHTVTTTEYWSESYTTTSTFTAPPGGTDSVIIKEPPNPTVTTTEYWSESYTTTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSYTTTTTVIAPPGGTDSVIIREPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYTTTTTVIAPPGGTDSVIIKEPPNPTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSYATTTTITAPPGETDTVLIREPPNHTVTTTEYWSQSFATTTTVTAPPGGTDTVIIREPPNHTVTTTEYWSQSFATTTTIIAPPGETDTVLIREPPNPTVTTTEYWSQSYTTATTVTAPPGGTDTVIIYDTMSSSEISSFSRPHYTNHTTLWSTTWVIETKTITETSCEGDKGCSWVSVSTRIVTIPNNIETPMVTNTVDTTTTESTLQSPSGIFSESGVSVETESSTFTTAQTNPSVPTTESEVVFTTKGNNGNGPYESPSTNVKSSMDENSEFTTSTAASTSTDIENETIATTGSVEASSPIISSSADETTTVTTTAESTSVIEQQTNNNGGGNAPSATSTSSPSTTTTANSDSVITSTTSTNQSQSQSNSDTQQTTLSQQMTSSLVSLHMLTTFDGSGSVIQHSTWLCGLITLLSLFI
UniProt ID: Q5A2Z7
Variant: L -> S at position 70-70
Variant annotation: in allele ALS6-2
Protein function: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections.
Reference sequence:
MKTVILLHLFFYCTIAMAKTISGVFTSFNSLTYTNTGNYPYGGPGYPTWTAVLGWSLDGTLASPGDTFTLVMPCVFKFITTQTSVDLTANGVKYATCTFHAGEDFTTFSSMSCVVNNGLSSNIRAFGTVRLPISFNVGGTGSSVNIQDSKCFTAGTNTVTFTDGDHKISTTVNFPKTPQSSSSLVYFARVIPSLDKLSSLVVASQCTAGYASGVLGFSATKDDVTIDCSTIHVGITNGLNSWNMPVSSESFSYTKTCTPNSFIITYENVPAGYRPFIDSYVKKSATATNGFNLNYTNIYNCMDGKKGNDPLIYFWTSYTNSDAGSNGAAVVVTTRTVTDSTTAITTLPFDPTVDKTKTIEVIEPIPTTTITTSYVGISTSLSTKTATIGGTATVVVDVPYHTTTTITSIWTGSATTSSTYTNPTDSIDTVVVQVPSPNPTVTTTQFWSGSVPTTETVTTGPQGTDSVIIKEPHNPTVTTTEFWSESFATTETVTNGPEGTDSVIVREPHNPTVTTTEFWSESFATTETVTNGPEGTDSVIVREPHNPTVTTTEFWSESFATTETITTGPLGTDSIVIHDPLEESSSSTAIESSDSNISSSAQESSSSVEQSLTSADETSSIVELSSSSDIPSSSIGLTSSESSTVSSYDSYSSSTSESSIASSYDSYWSSSIESSTLSSSDRYSSSISDTTSFWDSSSSDLESTSITWSSSIDAQSSHLVQSVSNSISTSQELSSSSSEESSTSATDALVSSDASSILSSDTSSYYPSSTISPSDDFPHTIAGESDSQSISFITSTVEISSDSVSLTSDPASSFDSSSSLNSDSSSSPSSDQSDILTSSSFSTLVVPSFSLSSSSSLSLTYPHYVNSTTYHASESESSSVASPSMASESANDDTHTLSESTDTTSSIGTDSSTVTFCRRDNGDGCIVTGMPSSSIDSEQTSDVTTTSSFVASSTPTSAEQSITDNPNIDSSQTSASSSTKLSVFVSDTVVNSISLSETSTLSSDDSTSSDTSISSTTNSDTGNINAGSSHTSTASIKESSIQKTGVMLSSSYLSTKLSSTSDITTELITTELTTTELTTIEDNEPNTFTSTPSSHSEIFSSDNSVLSKQVDGESTVEIPPVTDTTTVSSVSVHSIEASTATLGENSFSKVASAPVNTETSLRSTSSSSNHATESSGTVKSEASAEAIPSPPTSTDNRLSYSTEEAKGSTYANSGSTNNLMTESQVAAPTDSTSVLTANPVVTSTFDDKSSAAVNQPSKTKSIEESIGSLDSVNETNNGFIATLSQSEAPNSLIHSESISTTMAKTTDASINGDSAASNSQPTTLIQQVATSSYNQPLITTYAGSSSATKHPSWLLKFISVALFFFL
UniProt ID: Q5A2Z7
Variant: S -> L at position 856-856
Variant annotation: in allele ALS6-2
Protein function: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections.
Reference sequence:
MKTVILLHLFFYCTIAMAKTISGVFTSFNSLTYTNTGNYPYGGPGYPTWTAVLGWSLDGTLASPGDTFTLVMPCVFKFITTQTSVDLTANGVKYATCTFHAGEDFTTFSSMSCVVNNGLSSNIRAFGTVRLPISFNVGGTGSSVNIQDSKCFTAGTNTVTFTDGDHKISTTVNFPKTPQSSSSLVYFARVIPSLDKLSSLVVASQCTAGYASGVLGFSATKDDVTIDCSTIHVGITNGLNSWNMPVSSESFSYTKTCTPNSFIITYENVPAGYRPFIDSYVKKSATATNGFNLNYTNIYNCMDGKKGNDPLIYFWTSYTNSDAGSNGAAVVVTTRTVTDSTTAITTLPFDPTVDKTKTIEVIEPIPTTTITTSYVGISTSLSTKTATIGGTATVVVDVPYHTTTTITSIWTGSATTSSTYTNPTDSIDTVVVQVPSPNPTVTTTQFWSGSVPTTETVTTGPQGTDSVIIKEPHNPTVTTTEFWSESFATTETVTNGPEGTDSVIVREPHNPTVTTTEFWSESFATTETVTNGPEGTDSVIVREPHNPTVTTTEFWSESFATTETITTGPLGTDSIVIHDPLEESSSSTAIESSDSNISSSAQESSSSVEQSLTSADETSSIVELSSSSDIPSSSIGLTSSESSTVSSYDSYSSSTSESSIASSYDSYWSSSIESSTLSSSDRYSSSISDTTSFWDSSSSDLESTSITWSSSIDAQSSHLVQSVSNSISTSQELSSSSSEESSTSATDALVSSDASSILSSDTSSYYPSSTISPSDDFPHTIAGESDSQSISFITSTVEISSDSVSLTSDPASSFDSSSSLNSDSSSSPSSDQSDILTSSSFSTLVVPSFSLSSSSSLSLTYPHYVNSTTYHASESESSSVASPSMASESANDDTHTLSESTDTTSSIGTDSSTVTFCRRDNGDGCIVTGMPSSSIDSEQTSDVTTTSSFVASSTPTSAEQSITDNPNIDSSQTSASSSTKLSVFVSDTVVNSISLSETSTLSSDDSTSSDTSISSTTNSDTGNINAGSSHTSTASIKESSIQKTGVMLSSSYLSTKLSSTSDITTELITTELTTTELTTIEDNEPNTFTSTPSSHSEIFSSDNSVLSKQVDGESTVEIPPVTDTTTVSSVSVHSIEASTATLGENSFSKVASAPVNTETSLRSTSSSSNHATESSGTVKSEASAEAIPSPPTSTDNRLSYSTEEAKGSTYANSGSTNNLMTESQVAAPTDSTSVLTANPVVTSTFDDKSSAAVNQPSKTKSIEESIGSLDSVNETNNGFIATLSQSEAPNSLIHSESISTTMAKTTDASINGDSAASNSQPTTLIQQVATSSYNQPLITTYAGSSSATKHPSWLLKFISVALFFFL
UniProt ID: Q5A2Z7
Variant: I -> V at position 907-907
Variant annotation: in allele ALS6-2
Protein function: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections.
Reference sequence:
MKTVILLHLFFYCTIAMAKTISGVFTSFNSLTYTNTGNYPYGGPGYPTWTAVLGWSLDGTLASPGDTFTLVMPCVFKFITTQTSVDLTANGVKYATCTFHAGEDFTTFSSMSCVVNNGLSSNIRAFGTVRLPISFNVGGTGSSVNIQDSKCFTAGTNTVTFTDGDHKISTTVNFPKTPQSSSSLVYFARVIPSLDKLSSLVVASQCTAGYASGVLGFSATKDDVTIDCSTIHVGITNGLNSWNMPVSSESFSYTKTCTPNSFIITYENVPAGYRPFIDSYVKKSATATNGFNLNYTNIYNCMDGKKGNDPLIYFWTSYTNSDAGSNGAAVVVTTRTVTDSTTAITTLPFDPTVDKTKTIEVIEPIPTTTITTSYVGISTSLSTKTATIGGTATVVVDVPYHTTTTITSIWTGSATTSSTYTNPTDSIDTVVVQVPSPNPTVTTTQFWSGSVPTTETVTTGPQGTDSVIIKEPHNPTVTTTEFWSESFATTETVTNGPEGTDSVIVREPHNPTVTTTEFWSESFATTETVTNGPEGTDSVIVREPHNPTVTTTEFWSESFATTETITTGPLGTDSIVIHDPLEESSSSTAIESSDSNISSSAQESSSSVEQSLTSADETSSIVELSSSSDIPSSSIGLTSSESSTVSSYDSYSSSTSESSIASSYDSYWSSSIESSTLSSSDRYSSSISDTTSFWDSSSSDLESTSITWSSSIDAQSSHLVQSVSNSISTSQELSSSSSEESSTSATDALVSSDASSILSSDTSSYYPSSTISPSDDFPHTIAGESDSQSISFITSTVEISSDSVSLTSDPASSFDSSSSLNSDSSSSPSSDQSDILTSSSFSTLVVPSFSLSSSSSLSLTYPHYVNSTTYHASESESSSVASPSMASESANDDTHTLSESTDTTSSIGTDSSTVTFCRRDNGDGCIVTGMPSSSIDSEQTSDVTTTSSFVASSTPTSAEQSITDNPNIDSSQTSASSSTKLSVFVSDTVVNSISLSETSTLSSDDSTSSDTSISSTTNSDTGNINAGSSHTSTASIKESSIQKTGVMLSSSYLSTKLSSTSDITTELITTELTTTELTTIEDNEPNTFTSTPSSHSEIFSSDNSVLSKQVDGESTVEIPPVTDTTTVSSVSVHSIEASTATLGENSFSKVASAPVNTETSLRSTSSSSNHATESSGTVKSEASAEAIPSPPTSTDNRLSYSTEEAKGSTYANSGSTNNLMTESQVAAPTDSTSVLTANPVVTSTFDDKSSAAVNQPSKTKSIEESIGSLDSVNETNNGFIATLSQSEAPNSLIHSESISTTMAKTTDASINGDSAASNSQPTTLIQQVATSSYNQPLITTYAGSSSATKHPSWLLKFISVALFFFL
UniProt ID: Q5A2Z7
Variant: D -> G at position 1230-1230
Variant annotation: in allele ALS6-2
Protein function: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections.
Reference sequence:
MKTVILLHLFFYCTIAMAKTISGVFTSFNSLTYTNTGNYPYGGPGYPTWTAVLGWSLDGTLASPGDTFTLVMPCVFKFITTQTSVDLTANGVKYATCTFHAGEDFTTFSSMSCVVNNGLSSNIRAFGTVRLPISFNVGGTGSSVNIQDSKCFTAGTNTVTFTDGDHKISTTVNFPKTPQSSSSLVYFARVIPSLDKLSSLVVASQCTAGYASGVLGFSATKDDVTIDCSTIHVGITNGLNSWNMPVSSESFSYTKTCTPNSFIITYENVPAGYRPFIDSYVKKSATATNGFNLNYTNIYNCMDGKKGNDPLIYFWTSYTNSDAGSNGAAVVVTTRTVTDSTTAITTLPFDPTVDKTKTIEVIEPIPTTTITTSYVGISTSLSTKTATIGGTATVVVDVPYHTTTTITSIWTGSATTSSTYTNPTDSIDTVVVQVPSPNPTVTTTQFWSGSVPTTETVTTGPQGTDSVIIKEPHNPTVTTTEFWSESFATTETVTNGPEGTDSVIVREPHNPTVTTTEFWSESFATTETVTNGPEGTDSVIVREPHNPTVTTTEFWSESFATTETITTGPLGTDSIVIHDPLEESSSSTAIESSDSNISSSAQESSSSVEQSLTSADETSSIVELSSSSDIPSSSIGLTSSESSTVSSYDSYSSSTSESSIASSYDSYWSSSIESSTLSSSDRYSSSISDTTSFWDSSSSDLESTSITWSSSIDAQSSHLVQSVSNSISTSQELSSSSSEESSTSATDALVSSDASSILSSDTSSYYPSSTISPSDDFPHTIAGESDSQSISFITSTVEISSDSVSLTSDPASSFDSSSSLNSDSSSSPSSDQSDILTSSSFSTLVVPSFSLSSSSSLSLTYPHYVNSTTYHASESESSSVASPSMASESANDDTHTLSESTDTTSSIGTDSSTVTFCRRDNGDGCIVTGMPSSSIDSEQTSDVTTTSSFVASSTPTSAEQSITDNPNIDSSQTSASSSTKLSVFVSDTVVNSISLSETSTLSSDDSTSSDTSISSTTNSDTGNINAGSSHTSTASIKESSIQKTGVMLSSSYLSTKLSSTSDITTELITTELTTTELTTIEDNEPNTFTSTPSSHSEIFSSDNSVLSKQVDGESTVEIPPVTDTTTVSSVSVHSIEASTATLGENSFSKVASAPVNTETSLRSTSSSSNHATESSGTVKSEASAEAIPSPPTSTDNRLSYSTEEAKGSTYANSGSTNNLMTESQVAAPTDSTSVLTANPVVTSTFDDKSSAAVNQPSKTKSIEESIGSLDSVNETNNGFIATLSQSEAPNSLIHSESISTTMAKTTDASINGDSAASNSQPTTLIQQVATSSYNQPLITTYAGSSSATKHPSWLLKFISVALFFFL
UniProt ID: Q5A2Z7
Variant: N -> S at position 1238-1238
Variant annotation: in allele ALS6-2
Protein function: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections.
Reference sequence:
MKTVILLHLFFYCTIAMAKTISGVFTSFNSLTYTNTGNYPYGGPGYPTWTAVLGWSLDGTLASPGDTFTLVMPCVFKFITTQTSVDLTANGVKYATCTFHAGEDFTTFSSMSCVVNNGLSSNIRAFGTVRLPISFNVGGTGSSVNIQDSKCFTAGTNTVTFTDGDHKISTTVNFPKTPQSSSSLVYFARVIPSLDKLSSLVVASQCTAGYASGVLGFSATKDDVTIDCSTIHVGITNGLNSWNMPVSSESFSYTKTCTPNSFIITYENVPAGYRPFIDSYVKKSATATNGFNLNYTNIYNCMDGKKGNDPLIYFWTSYTNSDAGSNGAAVVVTTRTVTDSTTAITTLPFDPTVDKTKTIEVIEPIPTTTITTSYVGISTSLSTKTATIGGTATVVVDVPYHTTTTITSIWTGSATTSSTYTNPTDSIDTVVVQVPSPNPTVTTTQFWSGSVPTTETVTTGPQGTDSVIIKEPHNPTVTTTEFWSESFATTETVTNGPEGTDSVIVREPHNPTVTTTEFWSESFATTETVTNGPEGTDSVIVREPHNPTVTTTEFWSESFATTETITTGPLGTDSIVIHDPLEESSSSTAIESSDSNISSSAQESSSSVEQSLTSADETSSIVELSSSSDIPSSSIGLTSSESSTVSSYDSYSSSTSESSIASSYDSYWSSSIESSTLSSSDRYSSSISDTTSFWDSSSSDLESTSITWSSSIDAQSSHLVQSVSNSISTSQELSSSSSEESSTSATDALVSSDASSILSSDTSSYYPSSTISPSDDFPHTIAGESDSQSISFITSTVEISSDSVSLTSDPASSFDSSSSLNSDSSSSPSSDQSDILTSSSFSTLVVPSFSLSSSSSLSLTYPHYVNSTTYHASESESSSVASPSMASESANDDTHTLSESTDTTSSIGTDSSTVTFCRRDNGDGCIVTGMPSSSIDSEQTSDVTTTSSFVASSTPTSAEQSITDNPNIDSSQTSASSSTKLSVFVSDTVVNSISLSETSTLSSDDSTSSDTSISSTTNSDTGNINAGSSHTSTASIKESSIQKTGVMLSSSYLSTKLSSTSDITTELITTELTTTELTTIEDNEPNTFTSTPSSHSEIFSSDNSVLSKQVDGESTVEIPPVTDTTTVSSVSVHSIEASTATLGENSFSKVASAPVNTETSLRSTSSSSNHATESSGTVKSEASAEAIPSPPTSTDNRLSYSTEEAKGSTYANSGSTNNLMTESQVAAPTDSTSVLTANPVVTSTFDDKSSAAVNQPSKTKSIEESIGSLDSVNETNNGFIATLSQSEAPNSLIHSESISTTMAKTTDASINGDSAASNSQPTTLIQQVATSSYNQPLITTYAGSSSATKHPSWLLKFISVALFFFL
UniProt ID: Q5A2Z7
Variant: M -> T at position 1302-1302
Variant annotation: in allele ALS6-2
Protein function: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections.
Reference sequence:
MKTVILLHLFFYCTIAMAKTISGVFTSFNSLTYTNTGNYPYGGPGYPTWTAVLGWSLDGTLASPGDTFTLVMPCVFKFITTQTSVDLTANGVKYATCTFHAGEDFTTFSSMSCVVNNGLSSNIRAFGTVRLPISFNVGGTGSSVNIQDSKCFTAGTNTVTFTDGDHKISTTVNFPKTPQSSSSLVYFARVIPSLDKLSSLVVASQCTAGYASGVLGFSATKDDVTIDCSTIHVGITNGLNSWNMPVSSESFSYTKTCTPNSFIITYENVPAGYRPFIDSYVKKSATATNGFNLNYTNIYNCMDGKKGNDPLIYFWTSYTNSDAGSNGAAVVVTTRTVTDSTTAITTLPFDPTVDKTKTIEVIEPIPTTTITTSYVGISTSLSTKTATIGGTATVVVDVPYHTTTTITSIWTGSATTSSTYTNPTDSIDTVVVQVPSPNPTVTTTQFWSGSVPTTETVTTGPQGTDSVIIKEPHNPTVTTTEFWSESFATTETVTNGPEGTDSVIVREPHNPTVTTTEFWSESFATTETVTNGPEGTDSVIVREPHNPTVTTTEFWSESFATTETITTGPLGTDSIVIHDPLEESSSSTAIESSDSNISSSAQESSSSVEQSLTSADETSSIVELSSSSDIPSSSIGLTSSESSTVSSYDSYSSSTSESSIASSYDSYWSSSIESSTLSSSDRYSSSISDTTSFWDSSSSDLESTSITWSSSIDAQSSHLVQSVSNSISTSQELSSSSSEESSTSATDALVSSDASSILSSDTSSYYPSSTISPSDDFPHTIAGESDSQSISFITSTVEISSDSVSLTSDPASSFDSSSSLNSDSSSSPSSDQSDILTSSSFSTLVVPSFSLSSSSSLSLTYPHYVNSTTYHASESESSSVASPSMASESANDDTHTLSESTDTTSSIGTDSSTVTFCRRDNGDGCIVTGMPSSSIDSEQTSDVTTTSSFVASSTPTSAEQSITDNPNIDSSQTSASSSTKLSVFVSDTVVNSISLSETSTLSSDDSTSSDTSISSTTNSDTGNINAGSSHTSTASIKESSIQKTGVMLSSSYLSTKLSSTSDITTELITTELTTTELTTIEDNEPNTFTSTPSSHSEIFSSDNSVLSKQVDGESTVEIPPVTDTTTVSSVSVHSIEASTATLGENSFSKVASAPVNTETSLRSTSSSSNHATESSGTVKSEASAEAIPSPPTSTDNRLSYSTEEAKGSTYANSGSTNNLMTESQVAAPTDSTSVLTANPVVTSTFDDKSSAAVNQPSKTKSIEESIGSLDSVNETNNGFIATLSQSEAPNSLIHSESISTTMAKTTDASINGDSAASNSQPTTLIQQVATSSYNQPLITTYAGSSSATKHPSWLLKFISVALFFFL
UniProt ID: Q5A2Z7
Variant: I -> M at position 1310-1310
Variant annotation: in allele ALS6-2
Protein function: Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections.
Reference sequence:
MKTVILLHLFFYCTIAMAKTISGVFTSFNSLTYTNTGNYPYGGPGYPTWTAVLGWSLDGTLASPGDTFTLVMPCVFKFITTQTSVDLTANGVKYATCTFHAGEDFTTFSSMSCVVNNGLSSNIRAFGTVRLPISFNVGGTGSSVNIQDSKCFTAGTNTVTFTDGDHKISTTVNFPKTPQSSSSLVYFARVIPSLDKLSSLVVASQCTAGYASGVLGFSATKDDVTIDCSTIHVGITNGLNSWNMPVSSESFSYTKTCTPNSFIITYENVPAGYRPFIDSYVKKSATATNGFNLNYTNIYNCMDGKKGNDPLIYFWTSYTNSDAGSNGAAVVVTTRTVTDSTTAITTLPFDPTVDKTKTIEVIEPIPTTTITTSYVGISTSLSTKTATIGGTATVVVDVPYHTTTTITSIWTGSATTSSTYTNPTDSIDTVVVQVPSPNPTVTTTQFWSGSVPTTETVTTGPQGTDSVIIKEPHNPTVTTTEFWSESFATTETVTNGPEGTDSVIVREPHNPTVTTTEFWSESFATTETVTNGPEGTDSVIVREPHNPTVTTTEFWSESFATTETITTGPLGTDSIVIHDPLEESSSSTAIESSDSNISSSAQESSSSVEQSLTSADETSSIVELSSSSDIPSSSIGLTSSESSTVSSYDSYSSSTSESSIASSYDSYWSSSIESSTLSSSDRYSSSISDTTSFWDSSSSDLESTSITWSSSIDAQSSHLVQSVSNSISTSQELSSSSSEESSTSATDALVSSDASSILSSDTSSYYPSSTISPSDDFPHTIAGESDSQSISFITSTVEISSDSVSLTSDPASSFDSSSSLNSDSSSSPSSDQSDILTSSSFSTLVVPSFSLSSSSSLSLTYPHYVNSTTYHASESESSSVASPSMASESANDDTHTLSESTDTTSSIGTDSSTVTFCRRDNGDGCIVTGMPSSSIDSEQTSDVTTTSSFVASSTPTSAEQSITDNPNIDSSQTSASSSTKLSVFVSDTVVNSISLSETSTLSSDDSTSSDTSISSTTNSDTGNINAGSSHTSTASIKESSIQKTGVMLSSSYLSTKLSSTSDITTELITTELTTTELTTIEDNEPNTFTSTPSSHSEIFSSDNSVLSKQVDGESTVEIPPVTDTTTVSSVSVHSIEASTATLGENSFSKVASAPVNTETSLRSTSSSSNHATESSGTVKSEASAEAIPSPPTSTDNRLSYSTEEAKGSTYANSGSTNNLMTESQVAAPTDSTSVLTANPVVTSTFDDKSSAAVNQPSKTKSIEESIGSLDSVNETNNGFIATLSQSEAPNSLIHSESISTTMAKTTDASINGDSAASNSQPTTLIQQVATSSYNQPLITTYAGSSSATKHPSWLLKFISVALFFFL
UniProt ID: Q5A6B6
Variant: S -> STKHGKVDDSS at position 305-305
Variant annotation: in allele: CaO19.11256
Protein function: Serine/threonine-protein phosphatase that plays an important role in controlling colony morphology, filament extension and agar invasion. Down-regulates expression of NRG1 and affects the expression of multiple filament-specific transcripts in response to serum and 37 degrees Celsius. Plays a crucial role in virulence in a mouse model of systemic candidiasis.
Reference sequence:
MTVPFKIPISDLDYCLEQLLDHKPPKILPPETIQQLCHTLKTELLQTPNIISLQSPISVVGDIHGQYHDLLEIFQIGGSPPQTNYLFLGDYVDRGYYSVETISLLLVLKLRYPERVFLIRGNHESRTITTNYGFYTEVLNKYQGSADVWTFITDLFDYLPLGATIDGKIFACHGGLSPSCQQLDQIRAVDRFREIPHDGIMADLVWSDPDVAISDFKLSPRGAGYLFGNDVIDKFCQDNNLVQMIRAHQLCNEGYTSYWKGKCLTVWSAPNYCYRCGNKASVLEILHSNYDSKDPTNGSDGEISSINGEFIGVNTSFESFGDDDDDYNDYRNRFNNSSRLHKQQGVLPGQFFNVFEASKENDEDTLQGKSVNGINFDDELSTSDDTSGSGGNNNKGDFFAAFFQERPKRQQVEYFL