sujigwak/NVAR huggingface dataset:
UniProt ID: A0FGR8
Variant: S -> G at position 638-638
Variant annotation: in dbSNP:rs2305473
Protein function: Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) .
Reference sequence:
MTANRDAALSSHRHPGCAQRPRTPTFASSSQRRSAFGFDDGNFPGLGERSHAPGSRLGARRRAKTARGLRGHRQRGAGAGLSRPGSARAPSPPRPGGPENPGGVLSVELPGLLAQLARSFALLLPVYALGYLGLSFSWVLLALALLAWCRRSRGLKALRLCRALALLEDEERVVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANTHLSTFSFTKVDVGQQPLRINGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDVPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPVPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARNLPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEVRDEQHQCSLGNLKVPLSQLLTSEDMTVSQRFQLSNSGPNSTIKMKIALRVLHLEKRERPPDHQHSAQVKRPSVSKEGRKTSIKSHMSGSPGPGGSNTAPSTPVIGGSDKPGMEEKAQPPEAGPQGLHDLGRSSSSLLASPGHISVKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALASEELAKGWTQWYDLTEDGTRPQAMT
UniProt ID: A0M8Q6
Variant: N -> Y at position 34-34
Variant annotation: in IMGTALLELEIGLC7*01
Protein function: Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .
Reference sequence:
GQPKAAPSVTLFPPSSEELQANKATLVCLVSDFNPGAVTVAWKADGSPVKVGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCRVTHEGSTVEKTVAPAECS
UniProt ID: A0PJK1
Variant: A -> V at position 522-522
Variant annotation: in dbSNP:rs12604020
Protein function: High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose.
Reference sequence:
MAANSTSDLHTPGTQLSVADIIVITVYFALNVAVGIWSSCRASRNTVNGYFLAGRDMTWWPIGASLFASSEGSGLFIGLAGSGAAGGLAVAGFEWNATYVLLALAWVFVPIYISSEIVTLPEYIQKRYGGQRIRMYLSVLSLLLSVFTKISLDLYAGALFVHICLGWNFYLSTILTLGITALYTIAGGLAAVIYTDALQTLIMVVGAVILTIKAFDQIGGYGQLEAAYAQAIPSRTIANTTCHLPRTDAMHMFRDPHTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARDLNHAKAGSILASYLKMLPMGLIIMPGMISRALFPDDVGCVVPSECLRACGAEVGCSNIAYPKLVMELMPIGLRGLMIAVMLAALMSSLTSIFNSSSTLFTMDIWRRLRPRSGERELLLVGRLVIVALIGVSVAWIPVLQDSNSGQLFIYMQSVTSSLAPPVTAVFVLGVFWRRANEQGAFWGLIAGLVVGATRLVLEFLNPAPPCGEPDTRPAVLGSIHYLHFAVALFALSGAVVVAGSLLTPPPQSVQIENLTWWTLAQDVPLGTKAGDGQTPQKHAFWARVCGFNAILLMCVNIFFYAYFA
UniProt ID: A0PJW8
Variant: L -> P at position 60-60
Variant annotation: in dbSNP:rs9869
Protein function: May play a role in the early stages of epithelial differentiation or in apoptosis.
Reference sequence:
MANEVQDLLSPRKGGHPPAVKAGGMRISKKQEIGTLERHTKKTGFEKTSAIANVAKIQTLDALNDALEKLNYKFPATVHMAHQKPTPALEKVVPLKRIYIIQQPRKC
UniProt ID: A0PJW8
Variant: A -> T at position 66-66
Variant annotation: in dbSNP:rs12535
Protein function: May play a role in the early stages of epithelial differentiation or in apoptosis.
Reference sequence:
MANEVQDLLSPRKGGHPPAVKAGGMRISKKQEIGTLERHTKKTGFEKTSAIANVAKIQTLDALNDALEKLNYKFPATVHMAHQKPTPALEKVVPLKRIYIIQQPRKC
UniProt ID: A0QP27
Variant: V -> M at position 197-197
Variant annotation: increases resistance to BM212 with 4-fold increase in minimal inhibitory concentration (MIC) to BM212 in liquid and solid media
Protein function: Transports trehalose monomycolate (TMM) to the cell wall . Flips TMM across the inner membrane. Membrane potential is not required for this function . Transports probably phosphatidylethanolamine (PE) as well. Binds specifically both TMM and PE, but not trehalose dimycolate (TDM). Binds also diacylglycerol (DAG) and other phospholipids, including phosphatidylglycerol (PG), phosphatidylinositol (PI), and cardiolipin (CDL) . Contributes to membrane potential, cell wall composition, antibiotic susceptibility and fitness .
Reference sequence:
MFAWWGRTVYQFRYIVIGVMVALCLGGGVYGISLGNHVTQSGFYDEGSQSVAASLIGDEVYGRDRTSHVVAILTPPDDKKVTDKAWQKKVTEELDQVVKDHEDQIVGWVGWLKAPDTTDPTVSAMKTQDLRHTFISIPLQGDDDDEILKNYQVVEPELQQVNGGDIRLAGLNPLASELTGTIGEDQKRAEVAAIPLVAVVLFFVFGTVIAAALPAIIGGLAIAGALGIMRLVAEFTPVHFFAQPVVTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTVMTSGRTVVFSAVIIVASSVPLLLFPQGFLKSITYAIIASVMLAAILSITVLAAALAILGPRVDALGVTTLLKIPFLANWQFSRRIIDWFAEKTQKTKTREEVERGFWGRLVNVVMKRPIAFAAPILVVMVLLIIPLGQLSLGGISEKYLPPDNAVRQSQEQFDKLFPGFRTEPLTLVMKREDGEPITDAQIADMRAKALTVSGFTDPDNDPEKMWKERPANDSGSKDPSVRVIQNGLENRNDAAKKIDELRALQPPHGIEVFVGGTPALEQDSIHSLFDKLPLMALILIVTTTVLMFLAFGSVVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLMAPMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLITGAALILAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAVMKLLGDDCWWAPRWMKRVQEKLGLGETELPDERKRPTVRESETDQRALVGVGAPPPPPRPHDPTHPAPEPVRPMPPMRSNAPSAAGTARISTPPQPPQPPQAPAQQAGDEPATTRFAMARNAVRNAVNSAVHGGAGSAAAPTERAPRPGGPAQPPAPPQREEREIESWLGALRGPAPAKNVPQPPAQPQRPSTDTTRAMPPQGRPPAGPADRGNENAPTTAFSAQRPPNGGAPADATTAIPTPPQREQEPSTEKLNTREDAPEDPETKRRGGGMSAQDLLRREGRL
UniProt ID: A0QP27
Variant: Y -> C at position 257-257
Variant annotation: growth defect in both liquid and solid media; confers resistance to SQ109 and AU1235 with 2-fold and 4-fold increased resistance, respectively; disrupted membrane potential; increased cell wall hydrophobicity; more sensitive to ampicillin and the hydrophobic antibiotics, rifampicin and erythromycin, but no change in sensitivity to chloramphenicol or kanamycin, compared to wild-type
Protein function: Transports trehalose monomycolate (TMM) to the cell wall . Flips TMM across the inner membrane. Membrane potential is not required for this function . Transports probably phosphatidylethanolamine (PE) as well. Binds specifically both TMM and PE, but not trehalose dimycolate (TDM). Binds also diacylglycerol (DAG) and other phospholipids, including phosphatidylglycerol (PG), phosphatidylinositol (PI), and cardiolipin (CDL) . Contributes to membrane potential, cell wall composition, antibiotic susceptibility and fitness .
Reference sequence:
MFAWWGRTVYQFRYIVIGVMVALCLGGGVYGISLGNHVTQSGFYDEGSQSVAASLIGDEVYGRDRTSHVVAILTPPDDKKVTDKAWQKKVTEELDQVVKDHEDQIVGWVGWLKAPDTTDPTVSAMKTQDLRHTFISIPLQGDDDDEILKNYQVVEPELQQVNGGDIRLAGLNPLASELTGTIGEDQKRAEVAAIPLVAVVLFFVFGTVIAAALPAIIGGLAIAGALGIMRLVAEFTPVHFFAQPVVTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTVMTSGRTVVFSAVIIVASSVPLLLFPQGFLKSITYAIIASVMLAAILSITVLAAALAILGPRVDALGVTTLLKIPFLANWQFSRRIIDWFAEKTQKTKTREEVERGFWGRLVNVVMKRPIAFAAPILVVMVLLIIPLGQLSLGGISEKYLPPDNAVRQSQEQFDKLFPGFRTEPLTLVMKREDGEPITDAQIADMRAKALTVSGFTDPDNDPEKMWKERPANDSGSKDPSVRVIQNGLENRNDAAKKIDELRALQPPHGIEVFVGGTPALEQDSIHSLFDKLPLMALILIVTTTVLMFLAFGSVVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLMAPMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLITGAALILAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAVMKLLGDDCWWAPRWMKRVQEKLGLGETELPDERKRPTVRESETDQRALVGVGAPPPPPRPHDPTHPAPEPVRPMPPMRSNAPSAAGTARISTPPQPPQPPQAPAQQAGDEPATTRFAMARNAVRNAVNSAVHGGAGSAAAPTERAPRPGGPAQPPAPPQREEREIESWLGALRGPAPAKNVPQPPAQPQRPSTDTTRAMPPQGRPPAGPADRGNENAPTTAFSAQRPPNGGAPADATTAIPTPPQREQEPSTEKLNTREDAPEDPETKRRGGGMSAQDLLRREGRL
UniProt ID: A0QP27
Variant: S -> A at position 293-293
Variant annotation: growth defect in both liquid and solid media; confers resistance to SQ109 and AU1235 with 4-fold and 33-fold increased resistance, respectively; disrupted membrane potential; no significant difference in cell wall hydrophobicity; more sensitive to ampicillin and the hydrophobic antibiotics, rifampicin and erythromycin, but no change in sensitivity to chloramphenicol or kanamycin, compared to wild-type
Protein function: Transports trehalose monomycolate (TMM) to the cell wall . Flips TMM across the inner membrane. Membrane potential is not required for this function . Transports probably phosphatidylethanolamine (PE) as well. Binds specifically both TMM and PE, but not trehalose dimycolate (TDM). Binds also diacylglycerol (DAG) and other phospholipids, including phosphatidylglycerol (PG), phosphatidylinositol (PI), and cardiolipin (CDL) . Contributes to membrane potential, cell wall composition, antibiotic susceptibility and fitness .
Reference sequence:
MFAWWGRTVYQFRYIVIGVMVALCLGGGVYGISLGNHVTQSGFYDEGSQSVAASLIGDEVYGRDRTSHVVAILTPPDDKKVTDKAWQKKVTEELDQVVKDHEDQIVGWVGWLKAPDTTDPTVSAMKTQDLRHTFISIPLQGDDDDEILKNYQVVEPELQQVNGGDIRLAGLNPLASELTGTIGEDQKRAEVAAIPLVAVVLFFVFGTVIAAALPAIIGGLAIAGALGIMRLVAEFTPVHFFAQPVVTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTVMTSGRTVVFSAVIIVASSVPLLLFPQGFLKSITYAIIASVMLAAILSITVLAAALAILGPRVDALGVTTLLKIPFLANWQFSRRIIDWFAEKTQKTKTREEVERGFWGRLVNVVMKRPIAFAAPILVVMVLLIIPLGQLSLGGISEKYLPPDNAVRQSQEQFDKLFPGFRTEPLTLVMKREDGEPITDAQIADMRAKALTVSGFTDPDNDPEKMWKERPANDSGSKDPSVRVIQNGLENRNDAAKKIDELRALQPPHGIEVFVGGTPALEQDSIHSLFDKLPLMALILIVTTTVLMFLAFGSVVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLMAPMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLITGAALILAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAVMKLLGDDCWWAPRWMKRVQEKLGLGETELPDERKRPTVRESETDQRALVGVGAPPPPPRPHDPTHPAPEPVRPMPPMRSNAPSAAGTARISTPPQPPQPPQAPAQQAGDEPATTRFAMARNAVRNAVNSAVHGGAGSAAAPTERAPRPGGPAQPPAPPQREEREIESWLGALRGPAPAKNVPQPPAQPQRPSTDTTRAMPPQGRPPAGPADRGNENAPTTAFSAQRPPNGGAPADATTAIPTPPQREQEPSTEKLNTREDAPEDPETKRRGGGMSAQDLLRREGRL
UniProt ID: A0QP27
Variant: S -> T at position 293-293
Variant annotation: grows as wild-type in liquid media; weak binding to both SQ109 and ICA38 while the dissociation constant (Kd) value for AU1235 increases 6.6-fold compared with wild-type; 8-fold and 4-fold increased resistance to AU1235 and SQ109, respectively; disrupted membrane potential; increased cell wall hydrophobicity; more sensitive to ampicillin and the hydrophobic antibiotics, rifampicin and erythromycin, but no change in sensitivity to chloramphenicol or kanamycin, compared to wild-type
Protein function: Transports trehalose monomycolate (TMM) to the cell wall . Flips TMM across the inner membrane. Membrane potential is not required for this function . Transports probably phosphatidylethanolamine (PE) as well. Binds specifically both TMM and PE, but not trehalose dimycolate (TDM). Binds also diacylglycerol (DAG) and other phospholipids, including phosphatidylglycerol (PG), phosphatidylinositol (PI), and cardiolipin (CDL) . Contributes to membrane potential, cell wall composition, antibiotic susceptibility and fitness .
Reference sequence:
MFAWWGRTVYQFRYIVIGVMVALCLGGGVYGISLGNHVTQSGFYDEGSQSVAASLIGDEVYGRDRTSHVVAILTPPDDKKVTDKAWQKKVTEELDQVVKDHEDQIVGWVGWLKAPDTTDPTVSAMKTQDLRHTFISIPLQGDDDDEILKNYQVVEPELQQVNGGDIRLAGLNPLASELTGTIGEDQKRAEVAAIPLVAVVLFFVFGTVIAAALPAIIGGLAIAGALGIMRLVAEFTPVHFFAQPVVTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTVMTSGRTVVFSAVIIVASSVPLLLFPQGFLKSITYAIIASVMLAAILSITVLAAALAILGPRVDALGVTTLLKIPFLANWQFSRRIIDWFAEKTQKTKTREEVERGFWGRLVNVVMKRPIAFAAPILVVMVLLIIPLGQLSLGGISEKYLPPDNAVRQSQEQFDKLFPGFRTEPLTLVMKREDGEPITDAQIADMRAKALTVSGFTDPDNDPEKMWKERPANDSGSKDPSVRVIQNGLENRNDAAKKIDELRALQPPHGIEVFVGGTPALEQDSIHSLFDKLPLMALILIVTTTVLMFLAFGSVVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLMAPMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLITGAALILAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAVMKLLGDDCWWAPRWMKRVQEKLGLGETELPDERKRPTVRESETDQRALVGVGAPPPPPRPHDPTHPAPEPVRPMPPMRSNAPSAAGTARISTPPQPPQPPQAPAQQAGDEPATTRFAMARNAVRNAVNSAVHGGAGSAAAPTERAPRPGGPAQPPAPPQREEREIESWLGALRGPAPAKNVPQPPAQPQRPSTDTTRAMPPQGRPPAGPADRGNENAPTTAFSAQRPPNGGAPADATTAIPTPPQREQEPSTEKLNTREDAPEDPETKRRGGGMSAQDLLRREGRL
UniProt ID: A0QP27
Variant: I -> F at position 297-297
Variant annotation: growth defect in certain liquid medium; severely reduced binding to SQ109 and AU1235; no change in resistance and 4-fold increased resistance to SQ109 and AU1235, respectively; disrupted membrane potential; increased cell wall hydrophobicity; more sensitive to ampicillin and the hydrophobic antibiotics, rifampicin and erythromycin, but no change in sensitivity to chloramphenicol or kanamycin, compared to wild-type
Protein function: Transports trehalose monomycolate (TMM) to the cell wall . Flips TMM across the inner membrane. Membrane potential is not required for this function . Transports probably phosphatidylethanolamine (PE) as well. Binds specifically both TMM and PE, but not trehalose dimycolate (TDM). Binds also diacylglycerol (DAG) and other phospholipids, including phosphatidylglycerol (PG), phosphatidylinositol (PI), and cardiolipin (CDL) . Contributes to membrane potential, cell wall composition, antibiotic susceptibility and fitness .
Reference sequence:
MFAWWGRTVYQFRYIVIGVMVALCLGGGVYGISLGNHVTQSGFYDEGSQSVAASLIGDEVYGRDRTSHVVAILTPPDDKKVTDKAWQKKVTEELDQVVKDHEDQIVGWVGWLKAPDTTDPTVSAMKTQDLRHTFISIPLQGDDDDEILKNYQVVEPELQQVNGGDIRLAGLNPLASELTGTIGEDQKRAEVAAIPLVAVVLFFVFGTVIAAALPAIIGGLAIAGALGIMRLVAEFTPVHFFAQPVVTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTVMTSGRTVVFSAVIIVASSVPLLLFPQGFLKSITYAIIASVMLAAILSITVLAAALAILGPRVDALGVTTLLKIPFLANWQFSRRIIDWFAEKTQKTKTREEVERGFWGRLVNVVMKRPIAFAAPILVVMVLLIIPLGQLSLGGISEKYLPPDNAVRQSQEQFDKLFPGFRTEPLTLVMKREDGEPITDAQIADMRAKALTVSGFTDPDNDPEKMWKERPANDSGSKDPSVRVIQNGLENRNDAAKKIDELRALQPPHGIEVFVGGTPALEQDSIHSLFDKLPLMALILIVTTTVLMFLAFGSVVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLMAPMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLITGAALILAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAVMKLLGDDCWWAPRWMKRVQEKLGLGETELPDERKRPTVRESETDQRALVGVGAPPPPPRPHDPTHPAPEPVRPMPPMRSNAPSAAGTARISTPPQPPQPPQAPAQQAGDEPATTRFAMARNAVRNAVNSAVHGGAGSAAAPTERAPRPGGPAQPPAPPQREEREIESWLGALRGPAPAKNVPQPPAQPQRPSTDTTRAMPPQGRPPAGPADRGNENAPTTAFSAQRPPNGGAPADATTAIPTPPQREQEPSTEKLNTREDAPEDPETKRRGGGMSAQDLLRREGRL
UniProt ID: A0QP27
Variant: A -> T at position 326-326
Variant annotation: increases resistance to BM212 with 4-fold increase in minimal inhibitory concentration (MIC) to BM212 in liquid and solid media
Protein function: Transports trehalose monomycolate (TMM) to the cell wall . Flips TMM across the inner membrane. Membrane potential is not required for this function . Transports probably phosphatidylethanolamine (PE) as well. Binds specifically both TMM and PE, but not trehalose dimycolate (TDM). Binds also diacylglycerol (DAG) and other phospholipids, including phosphatidylglycerol (PG), phosphatidylinositol (PI), and cardiolipin (CDL) . Contributes to membrane potential, cell wall composition, antibiotic susceptibility and fitness .
Reference sequence:
MFAWWGRTVYQFRYIVIGVMVALCLGGGVYGISLGNHVTQSGFYDEGSQSVAASLIGDEVYGRDRTSHVVAILTPPDDKKVTDKAWQKKVTEELDQVVKDHEDQIVGWVGWLKAPDTTDPTVSAMKTQDLRHTFISIPLQGDDDDEILKNYQVVEPELQQVNGGDIRLAGLNPLASELTGTIGEDQKRAEVAAIPLVAVVLFFVFGTVIAAALPAIIGGLAIAGALGIMRLVAEFTPVHFFAQPVVTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTVMTSGRTVVFSAVIIVASSVPLLLFPQGFLKSITYAIIASVMLAAILSITVLAAALAILGPRVDALGVTTLLKIPFLANWQFSRRIIDWFAEKTQKTKTREEVERGFWGRLVNVVMKRPIAFAAPILVVMVLLIIPLGQLSLGGISEKYLPPDNAVRQSQEQFDKLFPGFRTEPLTLVMKREDGEPITDAQIADMRAKALTVSGFTDPDNDPEKMWKERPANDSGSKDPSVRVIQNGLENRNDAAKKIDELRALQPPHGIEVFVGGTPALEQDSIHSLFDKLPLMALILIVTTTVLMFLAFGSVVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLMAPMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLITGAALILAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAVMKLLGDDCWWAPRWMKRVQEKLGLGETELPDERKRPTVRESETDQRALVGVGAPPPPPRPHDPTHPAPEPVRPMPPMRSNAPSAAGTARISTPPQPPQPPQAPAQQAGDEPATTRFAMARNAVRNAVNSAVHGGAGSAAAPTERAPRPGGPAQPPAPPQREEREIESWLGALRGPAPAKNVPQPPAQPQRPSTDTTRAMPPQGRPPAGPADRGNENAPTTAFSAQRPPNGGAPADATTAIPTPPQREQEPSTEKLNTREDAPEDPETKRRGGGMSAQDLLRREGRL
UniProt ID: A0QP27
Variant: G -> D at position 750-750
Variant annotation: rescues the growth defect of A-293 variant by partially restoring the membrane potential
Protein function: Transports trehalose monomycolate (TMM) to the cell wall . Flips TMM across the inner membrane. Membrane potential is not required for this function . Transports probably phosphatidylethanolamine (PE) as well. Binds specifically both TMM and PE, but not trehalose dimycolate (TDM). Binds also diacylglycerol (DAG) and other phospholipids, including phosphatidylglycerol (PG), phosphatidylinositol (PI), and cardiolipin (CDL) . Contributes to membrane potential, cell wall composition, antibiotic susceptibility and fitness .
Reference sequence:
MFAWWGRTVYQFRYIVIGVMVALCLGGGVYGISLGNHVTQSGFYDEGSQSVAASLIGDEVYGRDRTSHVVAILTPPDDKKVTDKAWQKKVTEELDQVVKDHEDQIVGWVGWLKAPDTTDPTVSAMKTQDLRHTFISIPLQGDDDDEILKNYQVVEPELQQVNGGDIRLAGLNPLASELTGTIGEDQKRAEVAAIPLVAVVLFFVFGTVIAAALPAIIGGLAIAGALGIMRLVAEFTPVHFFAQPVVTLIGLGIAIDYGLFIVSRFREEIAEGYDTEAAVRRTVMTSGRTVVFSAVIIVASSVPLLLFPQGFLKSITYAIIASVMLAAILSITVLAAALAILGPRVDALGVTTLLKIPFLANWQFSRRIIDWFAEKTQKTKTREEVERGFWGRLVNVVMKRPIAFAAPILVVMVLLIIPLGQLSLGGISEKYLPPDNAVRQSQEQFDKLFPGFRTEPLTLVMKREDGEPITDAQIADMRAKALTVSGFTDPDNDPEKMWKERPANDSGSKDPSVRVIQNGLENRNDAAKKIDELRALQPPHGIEVFVGGTPALEQDSIHSLFDKLPLMALILIVTTTVLMFLAFGSVVLPIKAALMSALTLGSTMGILTWMFVDGHGSGLMNYTPQPLMAPMIGLIIAVIWGLSTDYEVFLVSRMVEARERGMSTAEAIRIGTATTGRLITGAALILAVVAGAFVFSDLVMMKYLAFGLLIALLLDATIIRMFLVPAVMKLLGDDCWWAPRWMKRVQEKLGLGETELPDERKRPTVRESETDQRALVGVGAPPPPPRPHDPTHPAPEPVRPMPPMRSNAPSAAGTARISTPPQPPQPPQAPAQQAGDEPATTRFAMARNAVRNAVNSAVHGGAGSAAAPTERAPRPGGPAQPPAPPQREEREIESWLGALRGPAPAKNVPQPPAQPQRPSTDTTRAMPPQGRPPAGPADRGNENAPTTAFSAQRPPNGGAPADATTAIPTPPQREQEPSTEKLNTREDAPEDPETKRRGGGMSAQDLLRREGRL
UniProt ID: A0T0G5
Variant: S -> G at position 35-35
Variant annotation: in strain: UTEX 646 / Bohlin
Protein function: Has a central role in coupling the hydrolysis of ATP to the transfer of proteins across the thylakoid membrane.
Reference sequence:
MLKNPFNNNSLINKYQSLINQINTLEDELKTLTDSELRATSFKLKKQYAESKNLESLIPKSFALTREASLRTLGLRHFDVQLIGGLVLNDKKIAEMKTGEGKTLVATLPAYLNALTEKGVHIVTVNDYLANRDQVSMGQIYRFLGLNTGLIQDGMPNFDRRENYKADITYVTNYEVTFDFLRDNMALNLKDVVLRPFNYCIIDEVDSILIDEAQTPLIISNNIQTPIEKYIVAAEITDYLELNTHYKVDEKNKNVILTEDGSKQIEQILSVQDLYDPRDPWIPYIINALKANALYFNNVHYIVQNNRIIIVDEFTGRIMADRRWGDGLHQAIEAKEKLPIRQKTETVAAITYQNFFLLYPKLSGMTGTGKTAETEFEKIYNLSVEQIPTERPTQRKDLPDLIYKDQFSKWNAVAQNCNQIAKIGQPILVGTTTVEKSEMLAQLLSEYKLSYQILNAKPENVRRESEIVAQAGKKGSITIATNMAGRGTDIILGGNINFKIQKKLYDILTLVKNFKRSKKENIFSSSLLSQFEGSSQKFLSVLVSLSNDQKFLKLSDLDILKILRENDCISIPITSYQCSIRYLIDELITYNKKHQEQENQIVKNLGGLYIIGTERNDSRRVDNQLRGRCGRQGDPGTSRFFLSLDDNLLRLFGGSKIQNFMQTQIPDDSPLESEFITKSLDSAQERVEERAYQQRKNLFDYDDVLNKQRNIVYHERRNILESISVQKNIFAYGEQIITELLIELKEDKSCNIEATNLIENLFGRNLVLNYIKTSSLSISNLDLSELKIYLFNEFWLTYQSKITELSIYGEGIIENLERSIILINTDRIWREHLQKMTLLREAVGWRGYGQRNPLYEYKQDAFYMFETREELLRHLVIYDLLRSSIL
UniProt ID: A0T0G5
Variant: QD -> HE at position 152-153
Variant annotation: in strain: UTEX 646 / Bohlin
Protein function: Has a central role in coupling the hydrolysis of ATP to the transfer of proteins across the thylakoid membrane.
Reference sequence:
MLKNPFNNNSLINKYQSLINQINTLEDELKTLTDSELRATSFKLKKQYAESKNLESLIPKSFALTREASLRTLGLRHFDVQLIGGLVLNDKKIAEMKTGEGKTLVATLPAYLNALTEKGVHIVTVNDYLANRDQVSMGQIYRFLGLNTGLIQDGMPNFDRRENYKADITYVTNYEVTFDFLRDNMALNLKDVVLRPFNYCIIDEVDSILIDEAQTPLIISNNIQTPIEKYIVAAEITDYLELNTHYKVDEKNKNVILTEDGSKQIEQILSVQDLYDPRDPWIPYIINALKANALYFNNVHYIVQNNRIIIVDEFTGRIMADRRWGDGLHQAIEAKEKLPIRQKTETVAAITYQNFFLLYPKLSGMTGTGKTAETEFEKIYNLSVEQIPTERPTQRKDLPDLIYKDQFSKWNAVAQNCNQIAKIGQPILVGTTTVEKSEMLAQLLSEYKLSYQILNAKPENVRRESEIVAQAGKKGSITIATNMAGRGTDIILGGNINFKIQKKLYDILTLVKNFKRSKKENIFSSSLLSQFEGSSQKFLSVLVSLSNDQKFLKLSDLDILKILRENDCISIPITSYQCSIRYLIDELITYNKKHQEQENQIVKNLGGLYIIGTERNDSRRVDNQLRGRCGRQGDPGTSRFFLSLDDNLLRLFGGSKIQNFMQTQIPDDSPLESEFITKSLDSAQERVEERAYQQRKNLFDYDDVLNKQRNIVYHERRNILESISVQKNIFAYGEQIITELLIELKEDKSCNIEATNLIENLFGRNLVLNYIKTSSLSISNLDLSELKIYLFNEFWLTYQSKITELSIYGEGIIENLERSIILINTDRIWREHLQKMTLLREAVGWRGYGQRNPLYEYKQDAFYMFETREELLRHLVIYDLLRSSIL
UniProt ID: A0T0G5
Variant: D -> G at position 183-183
Variant annotation: in strain: UTEX 646 / Bohlin
Protein function: Has a central role in coupling the hydrolysis of ATP to the transfer of proteins across the thylakoid membrane.
Reference sequence:
MLKNPFNNNSLINKYQSLINQINTLEDELKTLTDSELRATSFKLKKQYAESKNLESLIPKSFALTREASLRTLGLRHFDVQLIGGLVLNDKKIAEMKTGEGKTLVATLPAYLNALTEKGVHIVTVNDYLANRDQVSMGQIYRFLGLNTGLIQDGMPNFDRRENYKADITYVTNYEVTFDFLRDNMALNLKDVVLRPFNYCIIDEVDSILIDEAQTPLIISNNIQTPIEKYIVAAEITDYLELNTHYKVDEKNKNVILTEDGSKQIEQILSVQDLYDPRDPWIPYIINALKANALYFNNVHYIVQNNRIIIVDEFTGRIMADRRWGDGLHQAIEAKEKLPIRQKTETVAAITYQNFFLLYPKLSGMTGTGKTAETEFEKIYNLSVEQIPTERPTQRKDLPDLIYKDQFSKWNAVAQNCNQIAKIGQPILVGTTTVEKSEMLAQLLSEYKLSYQILNAKPENVRRESEIVAQAGKKGSITIATNMAGRGTDIILGGNINFKIQKKLYDILTLVKNFKRSKKENIFSSSLLSQFEGSSQKFLSVLVSLSNDQKFLKLSDLDILKILRENDCISIPITSYQCSIRYLIDELITYNKKHQEQENQIVKNLGGLYIIGTERNDSRRVDNQLRGRCGRQGDPGTSRFFLSLDDNLLRLFGGSKIQNFMQTQIPDDSPLESEFITKSLDSAQERVEERAYQQRKNLFDYDDVLNKQRNIVYHERRNILESISVQKNIFAYGEQIITELLIELKEDKSCNIEATNLIENLFGRNLVLNYIKTSSLSISNLDLSELKIYLFNEFWLTYQSKITELSIYGEGIIENLERSIILINTDRIWREHLQKMTLLREAVGWRGYGQRNPLYEYKQDAFYMFETREELLRHLVIYDLLRSSIL
UniProt ID: A0T0G5
Variant: D -> G at position 211-211
Variant annotation: in strain: UTEX 646 / Bohlin
Protein function: Has a central role in coupling the hydrolysis of ATP to the transfer of proteins across the thylakoid membrane.
Reference sequence:
MLKNPFNNNSLINKYQSLINQINTLEDELKTLTDSELRATSFKLKKQYAESKNLESLIPKSFALTREASLRTLGLRHFDVQLIGGLVLNDKKIAEMKTGEGKTLVATLPAYLNALTEKGVHIVTVNDYLANRDQVSMGQIYRFLGLNTGLIQDGMPNFDRRENYKADITYVTNYEVTFDFLRDNMALNLKDVVLRPFNYCIIDEVDSILIDEAQTPLIISNNIQTPIEKYIVAAEITDYLELNTHYKVDEKNKNVILTEDGSKQIEQILSVQDLYDPRDPWIPYIINALKANALYFNNVHYIVQNNRIIIVDEFTGRIMADRRWGDGLHQAIEAKEKLPIRQKTETVAAITYQNFFLLYPKLSGMTGTGKTAETEFEKIYNLSVEQIPTERPTQRKDLPDLIYKDQFSKWNAVAQNCNQIAKIGQPILVGTTTVEKSEMLAQLLSEYKLSYQILNAKPENVRRESEIVAQAGKKGSITIATNMAGRGTDIILGGNINFKIQKKLYDILTLVKNFKRSKKENIFSSSLLSQFEGSSQKFLSVLVSLSNDQKFLKLSDLDILKILRENDCISIPITSYQCSIRYLIDELITYNKKHQEQENQIVKNLGGLYIIGTERNDSRRVDNQLRGRCGRQGDPGTSRFFLSLDDNLLRLFGGSKIQNFMQTQIPDDSPLESEFITKSLDSAQERVEERAYQQRKNLFDYDDVLNKQRNIVYHERRNILESISVQKNIFAYGEQIITELLIELKEDKSCNIEATNLIENLFGRNLVLNYIKTSSLSISNLDLSELKIYLFNEFWLTYQSKITELSIYGEGIIENLERSIILINTDRIWREHLQKMTLLREAVGWRGYGQRNPLYEYKQDAFYMFETREELLRHLVIYDLLRSSIL
UniProt ID: A0T0G5
Variant: T -> A at position 374-374
Variant annotation: in strain: UTEX 646 / Bohlin
Protein function: Has a central role in coupling the hydrolysis of ATP to the transfer of proteins across the thylakoid membrane.
Reference sequence:
MLKNPFNNNSLINKYQSLINQINTLEDELKTLTDSELRATSFKLKKQYAESKNLESLIPKSFALTREASLRTLGLRHFDVQLIGGLVLNDKKIAEMKTGEGKTLVATLPAYLNALTEKGVHIVTVNDYLANRDQVSMGQIYRFLGLNTGLIQDGMPNFDRRENYKADITYVTNYEVTFDFLRDNMALNLKDVVLRPFNYCIIDEVDSILIDEAQTPLIISNNIQTPIEKYIVAAEITDYLELNTHYKVDEKNKNVILTEDGSKQIEQILSVQDLYDPRDPWIPYIINALKANALYFNNVHYIVQNNRIIIVDEFTGRIMADRRWGDGLHQAIEAKEKLPIRQKTETVAAITYQNFFLLYPKLSGMTGTGKTAETEFEKIYNLSVEQIPTERPTQRKDLPDLIYKDQFSKWNAVAQNCNQIAKIGQPILVGTTTVEKSEMLAQLLSEYKLSYQILNAKPENVRRESEIVAQAGKKGSITIATNMAGRGTDIILGGNINFKIQKKLYDILTLVKNFKRSKKENIFSSSLLSQFEGSSQKFLSVLVSLSNDQKFLKLSDLDILKILRENDCISIPITSYQCSIRYLIDELITYNKKHQEQENQIVKNLGGLYIIGTERNDSRRVDNQLRGRCGRQGDPGTSRFFLSLDDNLLRLFGGSKIQNFMQTQIPDDSPLESEFITKSLDSAQERVEERAYQQRKNLFDYDDVLNKQRNIVYHERRNILESISVQKNIFAYGEQIITELLIELKEDKSCNIEATNLIENLFGRNLVLNYIKTSSLSISNLDLSELKIYLFNEFWLTYQSKITELSIYGEGIIENLERSIILINTDRIWREHLQKMTLLREAVGWRGYGQRNPLYEYKQDAFYMFETREELLRHLVIYDLLRSSIL
UniProt ID: A1A519
Variant: P -> S at position 173-173
Variant annotation: in dbSNP:rs328694
Protein function: Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE).
Reference sequence:
MKRRQKRKHLENEESQETAEKGGGMSKSQEDALQPGSTRVAKGWSQGVGEVTSTSEYCSCVSSSRKLIHSGIQRIHRDSPQPQSPLAQVQERGETPPRSQHVSLSSYSSYKTCVSSLCVNKEERGMKIYYMQVQMNKGVAVSWETEETLESLEKQPRMEEVTLSEVVRVGTPPSDVSTRNLLSDSEPSGEEKEHEERTESDSLPGSPTVEDTPRAKTPDWLVTMENGFRCMACCRVFTTMEALQEHVQFGIREGFSCHVFHLTMAQLTGNMESESTQDEQEEENGNEKEEEEKPEAKEEEGQPTEEDLGLRRSWSQCPGCVFHSPKDRNS