sujigwak/NVAR huggingface dataset:
UniProt ID: P0CI79
Variant: S -> N at position 118-118
Variant annotation: in strain: ATCC 6633
Protein function: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Reference sequence:
MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVISKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDGTIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVAV
UniProt ID: P0CI79
Variant: A -> S at position 155-155
Variant annotation: in strain: ATCC 6633
Protein function: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Reference sequence:
MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVISKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDGTIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVAV
UniProt ID: P0CI79
Variant: H -> Q at position 171-171
Variant annotation: in strain: ATCC 6633
Protein function: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Reference sequence:
MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVISKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDGTIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVAV
UniProt ID: P0CJ41
Variant: V -> A at position 60-60
Variant annotation: in albofibrase-2
Protein function: The recombinant protein has fibrinogenolytic activity against the Aalpha chain (FGA) of fibrinogen. Activates plasminogen (PLG) (is 4-fold less active than urokinase). Has weak thrombin-like enzyme activity. Has enzymatic activity against a trypsin-like substrate (S-3013) and shows a weaker activity on an activated protein C substrate (S-3125).
Reference sequence:
MVLIRVLANLLILQLSYAQKSSELVVGGDECNINEHHSLVAIFNSTGFFCSGTLINQEWVVTAAHCDSKNFKMKFGAHSKKLLNEDEQIRNPKEKFICPNKKSNEILDKDIMLIKLDSPVSNSAHIAPLSLPSSPPSVGSVCRIMGWGSTTPIEVTYPDVPYCANINLLDDAECKPGYPELLPEYRTLCAGIVQGGKDTCGGDSGGPLICNEKLHGIVSYGGHPCGQSHKPGIYTNVFDYNDWIQSIIAGNTDATCLS
UniProt ID: P0CJ72
Variant: T -> I at position 13-13
Variant annotation: decreased cytoprotective action; dbSNP:rs11004928
Protein function: Plays a role as a neuroprotective and antiapoptotic factor.
Reference sequence:
MATPGFSCLLLSTSEIDLPMKRRV
UniProt ID: P0CK94
Variant: H -> R at position 34-34
Variant annotation: in strain: Isolate 240-3
Protein function: The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
Reference sequence:
MNKVKFYVLFTALLSSLCAHGAPQSITELCSEYHNTQIYTINDKILSYTESMAGKREMVIITFKSGATFQVEVPGSQHIDSQKKAIERMKDTLRITYLTETKIDKLCVWNNKTPNSIAAISMEN
UniProt ID: P0CK94
Variant: T -> A at position 96-96
Variant annotation: in strain: Isolate 240-3
Protein function: The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
Reference sequence:
MNKVKFYVLFTALLSSLCAHGAPQSITELCSEYHNTQIYTINDKILSYTESMAGKREMVIITFKSGATFQVEVPGSQHIDSQKKAIERMKDTLRITYLTETKIDKLCVWNNKTPNSIAAISMEN
UniProt ID: P0CL63
Variant: V -> I at position 28-28
Variant annotation: in strain: 297
Protein function: Virulence-associated protein essential for survival of the bacterium within the tick host and therefore within the natural life cycle of the Lyme disease spirochete.
Reference sequence:
MGKILFFGLLLICIFLGFFFYKQKENNVIYNKIVEKFDDNVFVDETYTYLFKDSNLKELVFIKSQLIIPELKHKKMIKATGYRADAYKALSTVYRFDFKVHDNKILGFKSVIFEGFEDAKVSKHENNLPSEKWQQLKDFNIGDPNINEKFFHLEFPFVVKNTLCVTISKGFFKKIKKLKRLKIMLISNEDREYKIDIENFLPKYNL
UniProt ID: P0CL63
Variant: K -> E at position 72-72
Variant annotation: in strain: 297
Protein function: Virulence-associated protein essential for survival of the bacterium within the tick host and therefore within the natural life cycle of the Lyme disease spirochete.
Reference sequence:
MGKILFFGLLLICIFLGFFFYKQKENNVIYNKIVEKFDDNVFVDETYTYLFKDSNLKELVFIKSQLIIPELKHKKMIKATGYRADAYKALSTVYRFDFKVHDNKILGFKSVIFEGFEDAKVSKHENNLPSEKWQQLKDFNIGDPNINEKFFHLEFPFVVKNTLCVTISKGFFKKIKKLKRLKIMLISNEDREYKIDIENFLPKYNL
UniProt ID: P0CL63
Variant: KMIKA -> EMMKS at position 75-79
Variant annotation: in strain: 297
Protein function: Virulence-associated protein essential for survival of the bacterium within the tick host and therefore within the natural life cycle of the Lyme disease spirochete.
Reference sequence:
MGKILFFGLLLICIFLGFFFYKQKENNVIYNKIVEKFDDNVFVDETYTYLFKDSNLKELVFIKSQLIIPELKHKKMIKATGYRADAYKALSTVYRFDFKVHDNKILGFKSVIFEGFEDAKVSKHENNLPSEKWQQLKDFNIGDPNINEKFFHLEFPFVVKNTLCVTISKGFFKKIKKLKRLKIMLISNEDREYKIDIENFLPKYNL
UniProt ID: P0CL63
Variant: M -> I at position 184-184
Variant annotation: in strain: 297
Protein function: Virulence-associated protein essential for survival of the bacterium within the tick host and therefore within the natural life cycle of the Lyme disease spirochete.
Reference sequence:
MGKILFFGLLLICIFLGFFFYKQKENNVIYNKIVEKFDDNVFVDETYTYLFKDSNLKELVFIKSQLIIPELKHKKMIKATGYRADAYKALSTVYRFDFKVHDNKILGFKSVIFEGFEDAKVSKHENNLPSEKWQQLKDFNIGDPNINEKFFHLEFPFVVKNTLCVTISKGFFKKIKKLKRLKIMLISNEDREYKIDIENFLPKYNL
UniProt ID: P0CL63
Variant: L -> F at position 206-206
Variant annotation: in strain: 297
Protein function: Virulence-associated protein essential for survival of the bacterium within the tick host and therefore within the natural life cycle of the Lyme disease spirochete.
Reference sequence:
MGKILFFGLLLICIFLGFFFYKQKENNVIYNKIVEKFDDNVFVDETYTYLFKDSNLKELVFIKSQLIIPELKHKKMIKATGYRADAYKALSTVYRFDFKVHDNKILGFKSVIFEGFEDAKVSKHENNLPSEKWQQLKDFNIGDPNINEKFFHLEFPFVVKNTLCVTISKGFFKKIKKLKRLKIMLISNEDREYKIDIENFLPKYNL
UniProt ID: P0CL64
Variant: T -> A at position 3-3
Variant annotation: in strain: CA-11.2A
Protein function: Catalyzes the synthesis of GMP from XMP.
Reference sequence:
MNTQAILVLDFGSQYSQLIARRIREIGVYTKVIPYYTPLKEIKNMNISGIILSGSPASVYSKEAPTLNMEIFNLKIPILGICYGMQIIVKLFGGLVSKDSKQEYGSSEIFLRDEKSLLFSELPNKFQIIMSHGDSIEKIPDNFKQLAFTKNCIASISNETQKIYGLQFHPEVTHSEFGDQIIKNFVFKICQAQINWSLEGNLETIVKKIKLKVGSKKVILGLSGGTDSLVCALLIKKAINENLICVFVNTGLLRKNEDKKILELKHQYDLNIKYIDASTKFLNRLKNISDPEEKRKIIGKEFVDVFEKITLEDQNIEYLAQGTIYSDVIESKSKDSSSSKIKSHHNVGGLPDKMSLKLLEPLNEFFKDEIIQIGINLGIKKESLYRHPFPGPGLAIRIIGEVTQEKINILQEADNILTEELFINDLYYQIRQAFVVLLPVKSVGVMGDQRTYEYTAVIRCVNTQDFMTAEWTELPYSFLKKVSSRIINEVRGINRVCYDISSKPPSTIEWE
UniProt ID: P0CL64
Variant: N -> D at position 68-68
Variant annotation: in strain: CA-11.2A
Protein function: Catalyzes the synthesis of GMP from XMP.
Reference sequence:
MNTQAILVLDFGSQYSQLIARRIREIGVYTKVIPYYTPLKEIKNMNISGIILSGSPASVYSKEAPTLNMEIFNLKIPILGICYGMQIIVKLFGGLVSKDSKQEYGSSEIFLRDEKSLLFSELPNKFQIIMSHGDSIEKIPDNFKQLAFTKNCIASISNETQKIYGLQFHPEVTHSEFGDQIIKNFVFKICQAQINWSLEGNLETIVKKIKLKVGSKKVILGLSGGTDSLVCALLIKKAINENLICVFVNTGLLRKNEDKKILELKHQYDLNIKYIDASTKFLNRLKNISDPEEKRKIIGKEFVDVFEKITLEDQNIEYLAQGTIYSDVIESKSKDSSSSKIKSHHNVGGLPDKMSLKLLEPLNEFFKDEIIQIGINLGIKKESLYRHPFPGPGLAIRIIGEVTQEKINILQEADNILTEELFINDLYYQIRQAFVVLLPVKSVGVMGDQRTYEYTAVIRCVNTQDFMTAEWTELPYSFLKKVSSRIINEVRGINRVCYDISSKPPSTIEWE
UniProt ID: P0CL64
Variant: I -> V at position 78-78
Variant annotation: in strain: CA-11.2A
Protein function: Catalyzes the synthesis of GMP from XMP.
Reference sequence:
MNTQAILVLDFGSQYSQLIARRIREIGVYTKVIPYYTPLKEIKNMNISGIILSGSPASVYSKEAPTLNMEIFNLKIPILGICYGMQIIVKLFGGLVSKDSKQEYGSSEIFLRDEKSLLFSELPNKFQIIMSHGDSIEKIPDNFKQLAFTKNCIASISNETQKIYGLQFHPEVTHSEFGDQIIKNFVFKICQAQINWSLEGNLETIVKKIKLKVGSKKVILGLSGGTDSLVCALLIKKAINENLICVFVNTGLLRKNEDKKILELKHQYDLNIKYIDASTKFLNRLKNISDPEEKRKIIGKEFVDVFEKITLEDQNIEYLAQGTIYSDVIESKSKDSSSSKIKSHHNVGGLPDKMSLKLLEPLNEFFKDEIIQIGINLGIKKESLYRHPFPGPGLAIRIIGEVTQEKINILQEADNILTEELFINDLYYQIRQAFVVLLPVKSVGVMGDQRTYEYTAVIRCVNTQDFMTAEWTELPYSFLKKVSSRIINEVRGINRVCYDISSKPPSTIEWE
UniProt ID: P0CL64
Variant: S -> R at position 106-106
Variant annotation: in strain: CA-11.2A
Protein function: Catalyzes the synthesis of GMP from XMP.
Reference sequence:
MNTQAILVLDFGSQYSQLIARRIREIGVYTKVIPYYTPLKEIKNMNISGIILSGSPASVYSKEAPTLNMEIFNLKIPILGICYGMQIIVKLFGGLVSKDSKQEYGSSEIFLRDEKSLLFSELPNKFQIIMSHGDSIEKIPDNFKQLAFTKNCIASISNETQKIYGLQFHPEVTHSEFGDQIIKNFVFKICQAQINWSLEGNLETIVKKIKLKVGSKKVILGLSGGTDSLVCALLIKKAINENLICVFVNTGLLRKNEDKKILELKHQYDLNIKYIDASTKFLNRLKNISDPEEKRKIIGKEFVDVFEKITLEDQNIEYLAQGTIYSDVIESKSKDSSSSKIKSHHNVGGLPDKMSLKLLEPLNEFFKDEIIQIGINLGIKKESLYRHPFPGPGLAIRIIGEVTQEKINILQEADNILTEELFINDLYYQIRQAFVVLLPVKSVGVMGDQRTYEYTAVIRCVNTQDFMTAEWTELPYSFLKKVSSRIINEVRGINRVCYDISSKPPSTIEWE
UniProt ID: P0CL64
Variant: R -> K at position 112-112
Variant annotation: in strain: CA-11.2A
Protein function: Catalyzes the synthesis of GMP from XMP.
Reference sequence:
MNTQAILVLDFGSQYSQLIARRIREIGVYTKVIPYYTPLKEIKNMNISGIILSGSPASVYSKEAPTLNMEIFNLKIPILGICYGMQIIVKLFGGLVSKDSKQEYGSSEIFLRDEKSLLFSELPNKFQIIMSHGDSIEKIPDNFKQLAFTKNCIASISNETQKIYGLQFHPEVTHSEFGDQIIKNFVFKICQAQINWSLEGNLETIVKKIKLKVGSKKVILGLSGGTDSLVCALLIKKAINENLICVFVNTGLLRKNEDKKILELKHQYDLNIKYIDASTKFLNRLKNISDPEEKRKIIGKEFVDVFEKITLEDQNIEYLAQGTIYSDVIESKSKDSSSSKIKSHHNVGGLPDKMSLKLLEPLNEFFKDEIIQIGINLGIKKESLYRHPFPGPGLAIRIIGEVTQEKINILQEADNILTEELFINDLYYQIRQAFVVLLPVKSVGVMGDQRTYEYTAVIRCVNTQDFMTAEWTELPYSFLKKVSSRIINEVRGINRVCYDISSKPPSTIEWE
UniProt ID: P0CL64
Variant: I -> L at position 182-182
Variant annotation: in strain: CA-11.2A
Protein function: Catalyzes the synthesis of GMP from XMP.
Reference sequence:
MNTQAILVLDFGSQYSQLIARRIREIGVYTKVIPYYTPLKEIKNMNISGIILSGSPASVYSKEAPTLNMEIFNLKIPILGICYGMQIIVKLFGGLVSKDSKQEYGSSEIFLRDEKSLLFSELPNKFQIIMSHGDSIEKIPDNFKQLAFTKNCIASISNETQKIYGLQFHPEVTHSEFGDQIIKNFVFKICQAQINWSLEGNLETIVKKIKLKVGSKKVILGLSGGTDSLVCALLIKKAINENLICVFVNTGLLRKNEDKKILELKHQYDLNIKYIDASTKFLNRLKNISDPEEKRKIIGKEFVDVFEKITLEDQNIEYLAQGTIYSDVIESKSKDSSSSKIKSHHNVGGLPDKMSLKLLEPLNEFFKDEIIQIGINLGIKKESLYRHPFPGPGLAIRIIGEVTQEKINILQEADNILTEELFINDLYYQIRQAFVVLLPVKSVGVMGDQRTYEYTAVIRCVNTQDFMTAEWTELPYSFLKKVSSRIINEVRGINRVCYDISSKPPSTIEWE
UniProt ID: P0CL64
Variant: D -> N at position 258-258
Variant annotation: in strain: CA-11.2A
Protein function: Catalyzes the synthesis of GMP from XMP.
Reference sequence:
MNTQAILVLDFGSQYSQLIARRIREIGVYTKVIPYYTPLKEIKNMNISGIILSGSPASVYSKEAPTLNMEIFNLKIPILGICYGMQIIVKLFGGLVSKDSKQEYGSSEIFLRDEKSLLFSELPNKFQIIMSHGDSIEKIPDNFKQLAFTKNCIASISNETQKIYGLQFHPEVTHSEFGDQIIKNFVFKICQAQINWSLEGNLETIVKKIKLKVGSKKVILGLSGGTDSLVCALLIKKAINENLICVFVNTGLLRKNEDKKILELKHQYDLNIKYIDASTKFLNRLKNISDPEEKRKIIGKEFVDVFEKITLEDQNIEYLAQGTIYSDVIESKSKDSSSSKIKSHHNVGGLPDKMSLKLLEPLNEFFKDEIIQIGINLGIKKESLYRHPFPGPGLAIRIIGEVTQEKINILQEADNILTEELFINDLYYQIRQAFVVLLPVKSVGVMGDQRTYEYTAVIRCVNTQDFMTAEWTELPYSFLKKVSSRIINEVRGINRVCYDISSKPPSTIEWE
UniProt ID: P0CL66
Variant: P -> S at position 35-35
Variant annotation: in strain: CA7
Protein function: Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells .
Reference sequence:
MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGEMKVLVSKEKNKDGKYDLIATVDKLELKGTSDKNNGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRLEYTGIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAATKKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK
UniProt ID: P0CL66
Variant: K -> N at position 39-39
Variant annotation: in strain: PBre and 21343WI
Protein function: Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells .
Reference sequence:
MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGEMKVLVSKEKNKDGKYDLIATVDKLELKGTSDKNNGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRLEYTGIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAATKKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK
UniProt ID: P0CL66
Variant: D -> H at position 59-59
Variant annotation: in strain: 42373NY3
Protein function: Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells .
Reference sequence:
MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGEMKVLVSKEKNKDGKYDLIATVDKLELKGTSDKNNGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRLEYTGIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAATKKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK
UniProt ID: P0CL66
Variant: I -> V at position 90-90
Variant annotation: in strain: CA8
Protein function: Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells .
Reference sequence:
MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGEMKVLVSKEKNKDGKYDLIATVDKLELKGTSDKNNGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRLEYTGIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAATKKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK
UniProt ID: P0CL66
Variant: V -> A at position 114-114
Variant annotation: in strain: PBre
Protein function: Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells .
Reference sequence:
MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGEMKVLVSKEKNKDGKYDLIATVDKLELKGTSDKNNGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRLEYTGIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAATKKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK
UniProt ID: P0CL66
Variant: N -> S at position 127-127
Variant annotation: in strain: CA8
Protein function: Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells .
Reference sequence:
MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGEMKVLVSKEKNKDGKYDLIATVDKLELKGTSDKNNGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRLEYTGIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAATKKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK
UniProt ID: P0CL66
Variant: VS -> LP at position 132-133
Variant annotation: in strain: CA8
Protein function: Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells .
Reference sequence:
MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGEMKVLVSKEKNKDGKYDLIATVDKLELKGTSDKNNGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRLEYTGIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAATKKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK
UniProt ID: P0CL66
Variant: R -> K at position 144-144
Variant annotation: in strain: 21343WI
Protein function: Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells .
Reference sequence:
MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGEMKVLVSKEKNKDGKYDLIATVDKLELKGTSDKNNGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRLEYTGIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAATKKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK
UniProt ID: P0CL66
Variant: G -> E at position 149-149
Variant annotation: in strain: PBre and 42373NY3
Protein function: Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells .
Reference sequence:
MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGEMKVLVSKEKNKDGKYDLIATVDKLELKGTSDKNNGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRLEYTGIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAATKKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK
UniProt ID: P0CL66
Variant: G -> S at position 164-164
Variant annotation: in strain: PBre
Protein function: Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells .
Reference sequence:
MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGEMKVLVSKEKNKDGKYDLIATVDKLELKGTSDKNNGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRLEYTGIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAATKKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK
UniProt ID: P0CL66
Variant: E -> A at position 196-196
Variant annotation: in strain: CA8 and 21343WI
Protein function: Induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells .
Reference sequence:
MKKYLLGIGLILALIACKQNVSSLDEKNSVSVDLPGEMKVLVSKEKNKDGKYDLIATVDKLELKGTSDKNNGSGVLEGVKADKSKVKLTISDDLGQTTLEVFKEDGKTLVSKKVTSKDKSSTEEKFNEKGEVSEKIITRADGTRLEYTGIKSDGSGKAKEVLKGYVLEGTLTAEKTTLVVKEGTVTLSKNISKSGEVSVELNDTDSSAATKKTAAWNSGTSTLTITVNSKKTKDLVFTKENTITVQQYDSNGTKLEGSAVEITKLDEIKNALK
UniProt ID: P0CN31
Variant: R -> K at position 84-84
Variant annotation: in strain: M1-106
Protein function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Reference sequence:
MGKDKLHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQELGKSSFKYAWVLDKLKAERERGITIDIALWKFETPRYQVTVIDAPGHRDFIKNMITGTSQADCAILIIATGIGEFEAGISKDGQTREHALLAFTLGVRQLIVACNKMDTCKWSEDRFNEIVKETNGFIKKVGYNPKAVPFVPISGWHGDNMLEETTNMPWYKGWTKETKSGVSKGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVKFAPTNVTTEVKSVEMHHEQIPEGLPGDNVGFNVKNVSIKDIRRGNVCGDSKNDPPMEAASFNAQVIVLNHPGQIGAGYTPVLDCHTAHIACKFAELIEKIDRRTGKVMEAAPKFVKSGDAAIVKLVAQKPLCVETYADYPPLGRFAVRDMRQTVAVGVIKSVDKTEKGGKVTKAAEKAAKKK
UniProt ID: P0CN31
Variant: K -> R at position 222-222
Variant annotation: in strain: B-3501
Protein function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Reference sequence:
MGKDKLHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQELGKSSFKYAWVLDKLKAERERGITIDIALWKFETPRYQVTVIDAPGHRDFIKNMITGTSQADCAILIIATGIGEFEAGISKDGQTREHALLAFTLGVRQLIVACNKMDTCKWSEDRFNEIVKETNGFIKKVGYNPKAVPFVPISGWHGDNMLEETTNMPWYKGWTKETKSGVSKGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVKFAPTNVTTEVKSVEMHHEQIPEGLPGDNVGFNVKNVSIKDIRRGNVCGDSKNDPPMEAASFNAQVIVLNHPGQIGAGYTPVLDCHTAHIACKFAELIEKIDRRTGKVMEAAPKFVKSGDAAIVKLVAQKPLCVETYADYPPLGRFAVRDMRQTVAVGVIKSVDKTEKGGKVTKAAEKAAKKK
UniProt ID: P0CN31
Variant: D -> S at position 231-231
Variant annotation: in strain: B-3501
Protein function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Reference sequence:
MGKDKLHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQELGKSSFKYAWVLDKLKAERERGITIDIALWKFETPRYQVTVIDAPGHRDFIKNMITGTSQADCAILIIATGIGEFEAGISKDGQTREHALLAFTLGVRQLIVACNKMDTCKWSEDRFNEIVKETNGFIKKVGYNPKAVPFVPISGWHGDNMLEETTNMPWYKGWTKETKSGVSKGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVKFAPTNVTTEVKSVEMHHEQIPEGLPGDNVGFNVKNVSIKDIRRGNVCGDSKNDPPMEAASFNAQVIVLNHPGQIGAGYTPVLDCHTAHIACKFAELIEKIDRRTGKVMEAAPKFVKSGDAAIVKLVAQKPLCVETYADYPPLGRFAVRDMRQTVAVGVIKSVDKTEKGGKVTKAAEKAAKKK
UniProt ID: P0CN31
Variant: IE -> SR at position 233-234
Variant annotation: in strain: B-3501 and M1-106
Protein function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Reference sequence:
MGKDKLHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQELGKSSFKYAWVLDKLKAERERGITIDIALWKFETPRYQVTVIDAPGHRDFIKNMITGTSQADCAILIIATGIGEFEAGISKDGQTREHALLAFTLGVRQLIVACNKMDTCKWSEDRFNEIVKETNGFIKKVGYNPKAVPFVPISGWHGDNMLEETTNMPWYKGWTKETKSGVSKGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVKFAPTNVTTEVKSVEMHHEQIPEGLPGDNVGFNVKNVSIKDIRRGNVCGDSKNDPPMEAASFNAQVIVLNHPGQIGAGYTPVLDCHTAHIACKFAELIEKIDRRTGKVMEAAPKFVKSGDAAIVKLVAQKPLCVETYADYPPLGRFAVRDMRQTVAVGVIKSVDKTEKGGKVTKAAEKAAKKK
UniProt ID: P0CN31
Variant: P -> H at position 236-236
Variant annotation: in strain: B-3501
Protein function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Reference sequence:
MGKDKLHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQELGKSSFKYAWVLDKLKAERERGITIDIALWKFETPRYQVTVIDAPGHRDFIKNMITGTSQADCAILIIATGIGEFEAGISKDGQTREHALLAFTLGVRQLIVACNKMDTCKWSEDRFNEIVKETNGFIKKVGYNPKAVPFVPISGWHGDNMLEETTNMPWYKGWTKETKSGVSKGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVKFAPTNVTTEVKSVEMHHEQIPEGLPGDNVGFNVKNVSIKDIRRGNVCGDSKNDPPMEAASFNAQVIVLNHPGQIGAGYTPVLDCHTAHIACKFAELIEKIDRRTGKVMEAAPKFVKSGDAAIVKLVAQKPLCVETYADYPPLGRFAVRDMRQTVAVGVIKSVDKTEKGGKVTKAAEKAAKKK
UniProt ID: P0CN31
Variant: A -> S at position 371-371
Variant annotation: in strain: M1-106
Protein function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Reference sequence:
MGKDKLHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQELGKSSFKYAWVLDKLKAERERGITIDIALWKFETPRYQVTVIDAPGHRDFIKNMITGTSQADCAILIIATGIGEFEAGISKDGQTREHALLAFTLGVRQLIVACNKMDTCKWSEDRFNEIVKETNGFIKKVGYNPKAVPFVPISGWHGDNMLEETTNMPWYKGWTKETKSGVSKGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVKFAPTNVTTEVKSVEMHHEQIPEGLPGDNVGFNVKNVSIKDIRRGNVCGDSKNDPPMEAASFNAQVIVLNHPGQIGAGYTPVLDCHTAHIACKFAELIEKIDRRTGKVMEAAPKFVKSGDAAIVKLVAQKPLCVETYADYPPLGRFAVRDMRQTVAVGVIKSVDKTEKGGKVTKAAEKAAKKK
UniProt ID: P0CN31
Variant: A -> S at position 404-404
Variant annotation: in strain: M1-106
Protein function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Reference sequence:
MGKDKLHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQELGKSSFKYAWVLDKLKAERERGITIDIALWKFETPRYQVTVIDAPGHRDFIKNMITGTSQADCAILIIATGIGEFEAGISKDGQTREHALLAFTLGVRQLIVACNKMDTCKWSEDRFNEIVKETNGFIKKVGYNPKAVPFVPISGWHGDNMLEETTNMPWYKGWTKETKSGVSKGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVKFAPTNVTTEVKSVEMHHEQIPEGLPGDNVGFNVKNVSIKDIRRGNVCGDSKNDPPMEAASFNAQVIVLNHPGQIGAGYTPVLDCHTAHIACKFAELIEKIDRRTGKVMEAAPKFVKSGDAAIVKLVAQKPLCVETYADYPPLGRFAVRDMRQTVAVGVIKSVDKTEKGGKVTKAAEKAAKKK
UniProt ID: P0CN31
Variant: DKTEKG -> EKSDGKS at position 440-445
Variant annotation: in strain: M1-106
Protein function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Reference sequence:
MGKDKLHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQELGKSSFKYAWVLDKLKAERERGITIDIALWKFETPRYQVTVIDAPGHRDFIKNMITGTSQADCAILIIATGIGEFEAGISKDGQTREHALLAFTLGVRQLIVACNKMDTCKWSEDRFNEIVKETNGFIKKVGYNPKAVPFVPISGWHGDNMLEETTNMPWYKGWTKETKSGVSKGKTLLEAIDAIEPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKAGMVVKFAPTNVTTEVKSVEMHHEQIPEGLPGDNVGFNVKNVSIKDIRRGNVCGDSKNDPPMEAASFNAQVIVLNHPGQIGAGYTPVLDCHTAHIACKFAELIEKIDRRTGKVMEAAPKFVKSGDAAIVKLVAQKPLCVETYADYPPLGRFAVRDMRQTVAVGVIKSVDKTEKGGKVTKAAEKAAKKK
UniProt ID: P0CS91
Variant: D -> G at position 651-651
Variant annotation: in strain: D273-10B
Protein function: Acts as a non-catalytic component of endonuclease SceI (endo.SceI), which cleaves specifically at multiple sites on mitochondrial DNA and produces double-stranded breaks. SSC1 confers broader sequence specificity, greater stability, and higher activity on the catalytic subunit.
Reference sequence:
MLAAKNILNRSSLSSSFRIATRLQSTKVQGSVIGIDLGTTNSAVAIMEGKVPKIIENAEGSRTTPSVVAFTKEGERLVGIPAKRQAVVNPENTLFATKRLIGRRFEDAEVQRDIKQVPYKIVKHSNGDAWVEARGQTYSPAQIGGFVLNKMKETAEAYLGKPVKNAVVTVPAYFNDSQRQATKDAGQIVGLNVLRVVNEPTAAALAYGLEKSDSKVVAVFDLGGGTFDISILDIDNGVFEVKSTNGDTHLGGEDFDIYLLREIVSRFKTETGIDLENDRMAIQRIREAAEKAKIELSSTVSTEINLPFITADASGPKHINMKFSRAQFETLTAPLVKRTVDPVKKALKDAGLSTSDISEVLLVGGMSRMPKVVETVKSLFGKDPSKAVNPDEAVAIGAAVQGAVLSGEVTDVLLLDVTPLSLGIETLGGVFTRLIPRNTTIPTKKSQIFSTAAAGQTSVEIRVFQGERELVRDNKLIGNFTLAGIPPAPKGVPQIEVTFDIDADGIINVSARDKATNKDSSITVAGSSGLSENEIEQMVNDAEKFKSQDEARKQAIETANKADQLANDTENSLKEFEGKVDKAEAQKVRDQITSLKELVARVQGGEEVNAEELKTKTEELQTSSMKLFEQLYKNDSNNNNNNNNGNNAESDETKQ