sujigwak/NVAR huggingface dataset:
UniProt ID: P80217
Variant: M -> V at position 128-128
Variant annotation: in dbSNP:rs588703
Protein function: Acts as a signaling pathway regulator involved in innate immune system response . In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation . In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production . In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries . Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion . Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines .
Reference sequence:
MSAPLDAALHALQEEQARLKMRLWDLQQLRKELGDSPKDKVPFSVPKIPLVFRGHTQQDPEVPKSLVSNLRIHCPLLAGSALITFDDPKVAEQVLQQKEHTINMEECRLRVQVQPLELPMVTTIQMSSQLSGRRVLVTGFPASLRLSEEELLDKLEIFFGKTRNGGGDVDVRELLPGSVMLGFARDGVAQRLCQIGQFTVPLGGQQVPLRVSPYVNGEIQKAEIRSQPVPRSVLVLNIPDILDGPELHDVLEIHFQKPTRGGGEVEALTVVPQGQQGLAVFTSESG
UniProt ID: P80232
Variant: F -> Y at position 82-82
Variant annotation: in isoform LM-70B
Protein function: Component of the cuticle of migratory locust which contains more than 100 different structural proteins.
Reference sequence:
GYLGGYAAPAVAVAPAPALAVAHAPAVVVATSYARISQVTNSVPIAVAAPAVPKAAVPVAAPVVAAAPVIAAHAPLALGHGFGYGGYH
UniProt ID: P80303
Variant: Q -> E at position 338-338
Variant annotation: in dbSNP:rs757081
Protein function: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance.
Reference sequence:
MRWRTILLQYCFLLITCLLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQGIPPSGPAGELKFEPHI
UniProt ID: P80370
Variant: Q -> L at position 73-73
Variant annotation: in dbSNP:rs34686110
Protein function: May have a role in neuroendocrine differentiation.
Reference sequence:
MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI
UniProt ID: P80370
Variant: R -> G at position 101-101
Variant annotation: in dbSNP:rs6575799
Protein function: May have a role in neuroendocrine differentiation.
Reference sequence:
MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI
UniProt ID: P80370
Variant: V -> M at position 104-104
Variant annotation: in dbSNP:rs2273607
Protein function: May have a role in neuroendocrine differentiation.
Reference sequence:
MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI
UniProt ID: P80370
Variant: D -> G at position 108-108
Variant annotation: in dbSNP:rs1058006
Protein function: May have a role in neuroendocrine differentiation.
Reference sequence:
MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI
UniProt ID: P80370
Variant: S -> N at position 260-260
Variant annotation: in dbSNP:rs1058009
Protein function: May have a role in neuroendocrine differentiation.
Reference sequence:
MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI
UniProt ID: P80462
Variant: V -> G at position 17-17
Protein function: Acts as a chaperone.
Reference sequence:
ARAVGIDLGTTNAVVAVLEG
UniProt ID: P81116
Variant: Q -> K at position 51-51
Protein function: Weakly agglutinates platelets at high doses by binding to GPIbalpha (GP1BA).
Reference sequence:
MGRFIFGSFGLLVLFLSLSGTGADCPSDWSSYDLYCYKVFQQRMNWEDAEQFCRQQHTGSHLLSFHSSEEVDFVVSKTLPILKADFVWIGLTDVWSACRLQWSDGTELKYNAWTAESECIASKTTDNQWWTRSCSRTYPFVCKLEV
UniProt ID: P81172
Variant: R -> G at position 59-59
Variant annotation: in HFE2B; dbSNP:rs779021719
Protein function: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa .
Reference sequence:
MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRDTHFPICIFCCGCCHRSKCGMCCKT
UniProt ID: P81172
Variant: C -> R at position 70-70
Variant annotation: in HFE2B; dbSNP:rs1374259518
Protein function: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa .
Reference sequence:
MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRDTHFPICIFCCGCCHRSKCGMCCKT
UniProt ID: P81172
Variant: G -> D at position 71-71
Variant annotation: in HFE2B; dbSNP:rs104894696
Protein function: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa .
Reference sequence:
MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRDTHFPICIFCCGCCHRSKCGMCCKT
UniProt ID: P81172
Variant: C -> Y at position 78-78
Variant annotation: in HFE2B; dbSNP:rs1462013476
Protein function: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa .
Reference sequence:
MALSSQIWAACLLLLLLLASLTSGSVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRDTHFPICIFCCGCCHRSKCGMCCKT
UniProt ID: P81176
Variant: PRS -> SRY at position 21-23
Protein function: Thrombin-like snake venom serine protease. Cleaves fibrinogen (beta chain of fibrinogen (FGB) and more slowly alpha chain (FGA)) without inducing fibrin clotting and cleaves kininogen to produce bradykinin (KNG), resulting in the reduction of blood pressure.
Reference sequence:
IIGGDECNINEHRFLVALYTPRSRTLFCGGTLINQEWVLTAAHCDRKNFRIKLGMHSKKVPNKDEQTRVPKEKFFCLSSKNYTLWDKDIMLIRLDSPVKNSTHIEPFSLPSSPPSVGSVCRIMGWGRISPTEETFPDVPHCVNINLLEYEMCRAPYPEFELPATSRTLCAGILEGGKDTCRGDSGGPLICNGQFQGIASWGDDPCAQPHKPAAYTKVFDHLDWIKSIIAGNTDASCPP
UniProt ID: P81371
Variant: I -> V at position 117-117
Protein function: Lectin that binds galactose.
Reference sequence:
SEVVSFSFTKFNPNPKDIILQGDALVTSKGKLQLTKVKDGKPVDHSLGRALYAAPIHIWDDSTDRVASFATSFSFVVEAPDESKTADGIAFFLAPPDTQPQKDGGFLGLFNDSNKSIQTVAVEFDTFSNTWDPSARHIGINVNSIESMKYVKWGWENGKVANVYISYEASTKTLTASLTYPSNATSYIVSANVDLKSALPEWVRVGFSATSGLSRDHVETHDVLDWSFTSTLQAPSDDSN
UniProt ID: P81371
Variant: M -> K at position 148-148
Protein function: Lectin that binds galactose.
Reference sequence:
SEVVSFSFTKFNPNPKDIILQGDALVTSKGKLQLTKVKDGKPVDHSLGRALYAAPIHIWDDSTDRVASFATSFSFVVEAPDESKTADGIAFFLAPPDTQPQKDGGFLGLFNDSNKSIQTVAVEFDTFSNTWDPSARHIGINVNSIESMKYVKWGWENGKVANVYISYEASTKTLTASLTYPSNATSYIVSANVDLKSALPEWVRVGFSATSGLSRDHVETHDVLDWSFTSTLQAPSDDSN
UniProt ID: P81371
Variant: G -> A at position 154-154
Protein function: Lectin that binds galactose.
Reference sequence:
SEVVSFSFTKFNPNPKDIILQGDALVTSKGKLQLTKVKDGKPVDHSLGRALYAAPIHIWDDSTDRVASFATSFSFVVEAPDESKTADGIAFFLAPPDTQPQKDGGFLGLFNDSNKSIQTVAVEFDTFSNTWDPSARHIGINVNSIESMKYVKWGWENGKVANVYISYEASTKTLTASLTYPSNATSYIVSANVDLKSALPEWVRVGFSATSGLSRDHVETHDVLDWSFTSTLQAPSDDSN
UniProt ID: P81371
Variant: E -> Q at position 168-168
Protein function: Lectin that binds galactose.
Reference sequence:
SEVVSFSFTKFNPNPKDIILQGDALVTSKGKLQLTKVKDGKPVDHSLGRALYAAPIHIWDDSTDRVASFATSFSFVVEAPDESKTADGIAFFLAPPDTQPQKDGGFLGLFNDSNKSIQTVAVEFDTFSNTWDPSARHIGINVNSIESMKYVKWGWENGKVANVYISYEASTKTLTASLTYPSNATSYIVSANVDLKSALPEWVRVGFSATSGLSRDHVETHDVLDWSFTSTLQAPSDDSN
UniProt ID: P81372
Variant: D -> E at position 17-17
Protein function: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Reference sequence:
ATYKVKLVTPQGQQEFDCPDDVYILDQAEEEGIDLPYSCRAGSCSSCAGKVKQGEVDQSDGSFLDDEQMEQGWVLTCVAFPTSDVVIETHKEEELTA
UniProt ID: P81397
Variant: I -> K at position 63-63
Protein function: Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.
Reference sequence:
DCPDGWSSTKSYCYRPFKEKKTWEEAERFCTEQEKEAHLVSMENRLEAVFVDMVMENNFENKIYRSWIGLKIENKGQRSNLEWSDGSSISYENLYEPYMEKCFLMDHQSGLPKWHTADCEEKNVFMCKFQLPR
UniProt ID: P81397
Variant: L -> K at position 70-70
Protein function: Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.
Reference sequence:
DCPDGWSSTKSYCYRPFKEKKTWEEAERFCTEQEKEAHLVSMENRLEAVFVDMVMENNFENKIYRSWIGLKIENKGQRSNLEWSDGSSISYENLYEPYMEKCFLMDHQSGLPKWHTADCEEKNVFMCKFQLPR
UniProt ID: P81398
Variant: E -> D at position 88-88
Protein function: Potent inhibitor of collagen-induced platelet aggregation. It acts by binding to the integrin alpha2A domain and blocks collagen binding to integrin alpha-2/beta-1 (ITGA2/ITGB1). The gamma/delta subunits mainly contribute to this activity.
Reference sequence:
DFRCPTTWSASKLYCYKPFKEKKTWIEAERFCAKQAENGHLVSIGSAAEADFLDLVIVVNFDKQRYRAWTGLTERNLKWTNGASVSYENLYEPYIRKCFVVQPWEGKSKWYKADCEEKNAFLCKFPKPH
UniProt ID: P81439
Variant: T -> S at position 35-35
Protein function: Potent inhibitor of papain-like cysteine proteinases (Ki=0.18-0.57 nM on papain), as well as of the aspartic proteinase cathepsin D (Ki=0.3-05 nM).
Reference sequence:
MALSQNQAKFSKGFVVMIWVLFIACAITSTEASLTKCQQLQASANSGLIGAYVPQCKETGEFEEKQCWGSTGYCWCVDEDGKEILGTKIRGSPDCSRRKAALTLCQMMQAIIVNVPGWCGPPSCKADGSFDEVQCCASNGECYCVDKKGKELEGTRQQGRPTCERHLSECEEARIKAHSNSLRVEMFVPECFEDGSYNPVQCWPSTGYCWCVDEGGVKVPGSDVRFKRPTC
UniProt ID: P81439
Variant: C -> V at position 74-74
Protein function: Potent inhibitor of papain-like cysteine proteinases (Ki=0.18-0.57 nM on papain), as well as of the aspartic proteinase cathepsin D (Ki=0.3-05 nM).
Reference sequence:
MALSQNQAKFSKGFVVMIWVLFIACAITSTEASLTKCQQLQASANSGLIGAYVPQCKETGEFEEKQCWGSTGYCWCVDEDGKEILGTKIRGSPDCSRRKAALTLCQMMQAIIVNVPGWCGPPSCKADGSFDEVQCCASNGECYCVDKKGKELEGTRQQGRPTCERHLSECEEARIKAHSNSLRVEMFVPECFEDGSYNPVQCWPSTGYCWCVDEGGVKVPGSDVRFKRPTC
UniProt ID: P81439
Variant: T -> S at position 162-162
Protein function: Potent inhibitor of papain-like cysteine proteinases (Ki=0.18-0.57 nM on papain), as well as of the aspartic proteinase cathepsin D (Ki=0.3-05 nM).
Reference sequence:
MALSQNQAKFSKGFVVMIWVLFIACAITSTEASLTKCQQLQASANSGLIGAYVPQCKETGEFEEKQCWGSTGYCWCVDEDGKEILGTKIRGSPDCSRRKAALTLCQMMQAIIVNVPGWCGPPSCKADGSFDEVQCCASNGECYCVDKKGKELEGTRQQGRPTCERHLSECEEARIKAHSNSLRVEMFVPECFEDGSYNPVQCWPSTGYCWCVDEGGVKVPGSDVRFKRPTC
UniProt ID: P81439
Variant: E -> P at position 169-169
Protein function: Potent inhibitor of papain-like cysteine proteinases (Ki=0.18-0.57 nM on papain), as well as of the aspartic proteinase cathepsin D (Ki=0.3-05 nM).
Reference sequence:
MALSQNQAKFSKGFVVMIWVLFIACAITSTEASLTKCQQLQASANSGLIGAYVPQCKETGEFEEKQCWGSTGYCWCVDEDGKEILGTKIRGSPDCSRRKAALTLCQMMQAIIVNVPGWCGPPSCKADGSFDEVQCCASNGECYCVDKKGKELEGTRQQGRPTCERHLSECEEARIKAHSNSLRVEMFVPECFEDGSYNPVQCWPSTGYCWCVDEGGVKVPGSDVRFKRPTC
UniProt ID: P81439
Variant: IK -> LQ at position 175-176
Protein function: Potent inhibitor of papain-like cysteine proteinases (Ki=0.18-0.57 nM on papain), as well as of the aspartic proteinase cathepsin D (Ki=0.3-05 nM).
Reference sequence:
MALSQNQAKFSKGFVVMIWVLFIACAITSTEASLTKCQQLQASANSGLIGAYVPQCKETGEFEEKQCWGSTGYCWCVDEDGKEILGTKIRGSPDCSRRKAALTLCQMMQAIIVNVPGWCGPPSCKADGSFDEVQCCASNGECYCVDKKGKELEGTRQQGRPTCERHLSECEEARIKAHSNSLRVEMFVPECFEDGSYNPVQCWPSTGYCWCVDEGGVKVPGSDVRFKRPTC
UniProt ID: P81439
Variant: V -> L at position 188-188
Protein function: Potent inhibitor of papain-like cysteine proteinases (Ki=0.18-0.57 nM on papain), as well as of the aspartic proteinase cathepsin D (Ki=0.3-05 nM).
Reference sequence:
MALSQNQAKFSKGFVVMIWVLFIACAITSTEASLTKCQQLQASANSGLIGAYVPQCKETGEFEEKQCWGSTGYCWCVDEDGKEILGTKIRGSPDCSRRKAALTLCQMMQAIIVNVPGWCGPPSCKADGSFDEVQCCASNGECYCVDKKGKELEGTRQQGRPTCERHLSECEEARIKAHSNSLRVEMFVPECFEDGSYNPVQCWPSTGYCWCVDEGGVKVPGSDVRFKRPTC
UniProt ID: P81439
Variant: G -> D at position 216-216
Protein function: Potent inhibitor of papain-like cysteine proteinases (Ki=0.18-0.57 nM on papain), as well as of the aspartic proteinase cathepsin D (Ki=0.3-05 nM).
Reference sequence:
MALSQNQAKFSKGFVVMIWVLFIACAITSTEASLTKCQQLQASANSGLIGAYVPQCKETGEFEEKQCWGSTGYCWCVDEDGKEILGTKIRGSPDCSRRKAALTLCQMMQAIIVNVPGWCGPPSCKADGSFDEVQCCASNGECYCVDKKGKELEGTRQQGRPTCERHLSECEEARIKAHSNSLRVEMFVPECFEDGSYNPVQCWPSTGYCWCVDEGGVKVPGSDVRFKRPTC
UniProt ID: P81446
Variant: E -> D at position 48-48
Variant annotation: in MLA'
Protein function: The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.
Reference sequence:
MNGHLASRRAWVWYFLMLGQVFGATVKAETKFSYERLRLRVTHQTTGEEYFRFITLLRDYVSSGSFSNEIPLLRQSTIPVSDAQRFVLVELTNEGGDSITAAIDVTNLYVVAYQAGDQSYFLRDAPRGAETHLFTGTTRSSLPFNGSYPDLERYAGHRDQIPLGIDQLIQSVTALRFPGGSTRTQARSILILIQMISEAARFNPILWRARQYINSGASFLPDVYMLELETSWGQQSTQVQQSTDGVFNNPIRLAIPPGNFVTLTNVRDVIASLAIMLFVCGERPSSSDVRYWPLVIRPVIADDVTCSASEPTVRIVGRNGMCVDVRDDDFHDGNQIQLWPSKSNNDPNQLWTIKRDGTIRSNGSCLTTYGYTAGVYVMIFDCNTAVREATLWEIWGNGTIINPRSNLVLAASSGIKGTTLTVQTLDYTLGQGWLAGNDTAPREVTIYGFRDLCMESNGGSVWVETCVISQQNQRWALYGDGSIRPKQNQDQCLTCGRDSVSTVINIVSCSAGSSGQRWVFTNEGAILNLKNGLAMDVAQANPKLRRIIIYPATGKPNQMWLPVP
UniProt ID: P81446
Variant: N -> T at position 145-145
Variant annotation: in MLA'
Protein function: The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.
Reference sequence:
MNGHLASRRAWVWYFLMLGQVFGATVKAETKFSYERLRLRVTHQTTGEEYFRFITLLRDYVSSGSFSNEIPLLRQSTIPVSDAQRFVLVELTNEGGDSITAAIDVTNLYVVAYQAGDQSYFLRDAPRGAETHLFTGTTRSSLPFNGSYPDLERYAGHRDQIPLGIDQLIQSVTALRFPGGSTRTQARSILILIQMISEAARFNPILWRARQYINSGASFLPDVYMLELETSWGQQSTQVQQSTDGVFNNPIRLAIPPGNFVTLTNVRDVIASLAIMLFVCGERPSSSDVRYWPLVIRPVIADDVTCSASEPTVRIVGRNGMCVDVRDDDFHDGNQIQLWPSKSNNDPNQLWTIKRDGTIRSNGSCLTTYGYTAGVYVMIFDCNTAVREATLWEIWGNGTIINPRSNLVLAASSGIKGTTLTVQTLDYTLGQGWLAGNDTAPREVTIYGFRDLCMESNGGSVWVETCVISQQNQRWALYGDGSIRPKQNQDQCLTCGRDSVSTVINIVSCSAGSSGQRWVFTNEGAILNLKNGLAMDVAQANPKLRRIIIYPATGKPNQMWLPVP
UniProt ID: P81446
Variant: P -> T at position 149-149
Variant annotation: in MLA'
Protein function: The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.
Reference sequence:
MNGHLASRRAWVWYFLMLGQVFGATVKAETKFSYERLRLRVTHQTTGEEYFRFITLLRDYVSSGSFSNEIPLLRQSTIPVSDAQRFVLVELTNEGGDSITAAIDVTNLYVVAYQAGDQSYFLRDAPRGAETHLFTGTTRSSLPFNGSYPDLERYAGHRDQIPLGIDQLIQSVTALRFPGGSTRTQARSILILIQMISEAARFNPILWRARQYINSGASFLPDVYMLELETSWGQQSTQVQQSTDGVFNNPIRLAIPPGNFVTLTNVRDVIASLAIMLFVCGERPSSSDVRYWPLVIRPVIADDVTCSASEPTVRIVGRNGMCVDVRDDDFHDGNQIQLWPSKSNNDPNQLWTIKRDGTIRSNGSCLTTYGYTAGVYVMIFDCNTAVREATLWEIWGNGTIINPRSNLVLAASSGIKGTTLTVQTLDYTLGQGWLAGNDTAPREVTIYGFRDLCMESNGGSVWVETCVISQQNQRWALYGDGSIRPKQNQDQCLTCGRDSVSTVINIVSCSAGSSGQRWVFTNEGAILNLKNGLAMDVAQANPKLRRIIIYPATGKPNQMWLPVP
UniProt ID: P81446
Variant: DQ -> EE at position 166-167
Variant annotation: in MLA'
Protein function: The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.
Reference sequence:
MNGHLASRRAWVWYFLMLGQVFGATVKAETKFSYERLRLRVTHQTTGEEYFRFITLLRDYVSSGSFSNEIPLLRQSTIPVSDAQRFVLVELTNEGGDSITAAIDVTNLYVVAYQAGDQSYFLRDAPRGAETHLFTGTTRSSLPFNGSYPDLERYAGHRDQIPLGIDQLIQSVTALRFPGGSTRTQARSILILIQMISEAARFNPILWRARQYINSGASFLPDVYMLELETSWGQQSTQVQQSTDGVFNNPIRLAIPPGNFVTLTNVRDVIASLAIMLFVCGERPSSSDVRYWPLVIRPVIADDVTCSASEPTVRIVGRNGMCVDVRDDDFHDGNQIQLWPSKSNNDPNQLWTIKRDGTIRSNGSCLTTYGYTAGVYVMIFDCNTAVREATLWEIWGNGTIINPRSNLVLAASSGIKGTTLTVQTLDYTLGQGWLAGNDTAPREVTIYGFRDLCMESNGGSVWVETCVISQQNQRWALYGDGSIRPKQNQDQCLTCGRDSVSTVINIVSCSAGSSGQRWVFTNEGAILNLKNGLAMDVAQANPKLRRIIIYPATGKPNQMWLPVP
UniProt ID: P81446
Variant: T -> S at position 173-173
Variant annotation: in MLA'
Protein function: The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.
Reference sequence:
MNGHLASRRAWVWYFLMLGQVFGATVKAETKFSYERLRLRVTHQTTGEEYFRFITLLRDYVSSGSFSNEIPLLRQSTIPVSDAQRFVLVELTNEGGDSITAAIDVTNLYVVAYQAGDQSYFLRDAPRGAETHLFTGTTRSSLPFNGSYPDLERYAGHRDQIPLGIDQLIQSVTALRFPGGSTRTQARSILILIQMISEAARFNPILWRARQYINSGASFLPDVYMLELETSWGQQSTQVQQSTDGVFNNPIRLAIPPGNFVTLTNVRDVIASLAIMLFVCGERPSSSDVRYWPLVIRPVIADDVTCSASEPTVRIVGRNGMCVDVRDDDFHDGNQIQLWPSKSNNDPNQLWTIKRDGTIRSNGSCLTTYGYTAGVYVMIFDCNTAVREATLWEIWGNGTIINPRSNLVLAASSGIKGTTLTVQTLDYTLGQGWLAGNDTAPREVTIYGFRDLCMESNGGSVWVETCVISQQNQRWALYGDGSIRPKQNQDQCLTCGRDSVSTVINIVSCSAGSSGQRWVFTNEGAILNLKNGLAMDVAQANPKLRRIIIYPATGKPNQMWLPVP
UniProt ID: P81446
Variant: F -> Y at position 177-177
Variant annotation: in MLA'
Protein function: The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.
Reference sequence:
MNGHLASRRAWVWYFLMLGQVFGATVKAETKFSYERLRLRVTHQTTGEEYFRFITLLRDYVSSGSFSNEIPLLRQSTIPVSDAQRFVLVELTNEGGDSITAAIDVTNLYVVAYQAGDQSYFLRDAPRGAETHLFTGTTRSSLPFNGSYPDLERYAGHRDQIPLGIDQLIQSVTALRFPGGSTRTQARSILILIQMISEAARFNPILWRARQYINSGASFLPDVYMLELETSWGQQSTQVQQSTDGVFNNPIRLAIPPGNFVTLTNVRDVIASLAIMLFVCGERPSSSDVRYWPLVIRPVIADDVTCSASEPTVRIVGRNGMCVDVRDDDFHDGNQIQLWPSKSNNDPNQLWTIKRDGTIRSNGSCLTTYGYTAGVYVMIFDCNTAVREATLWEIWGNGTIINPRSNLVLAASSGIKGTTLTVQTLDYTLGQGWLAGNDTAPREVTIYGFRDLCMESNGGSVWVETCVISQQNQRWALYGDGSIRPKQNQDQCLTCGRDSVSTVINIVSCSAGSSGQRWVFTNEGAILNLKNGLAMDVAQANPKLRRIIIYPATGKPNQMWLPVP
UniProt ID: P81446
Variant: T -> A at position 184-184
Variant annotation: in MLA'
Protein function: The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.
Reference sequence:
MNGHLASRRAWVWYFLMLGQVFGATVKAETKFSYERLRLRVTHQTTGEEYFRFITLLRDYVSSGSFSNEIPLLRQSTIPVSDAQRFVLVELTNEGGDSITAAIDVTNLYVVAYQAGDQSYFLRDAPRGAETHLFTGTTRSSLPFNGSYPDLERYAGHRDQIPLGIDQLIQSVTALRFPGGSTRTQARSILILIQMISEAARFNPILWRARQYINSGASFLPDVYMLELETSWGQQSTQVQQSTDGVFNNPIRLAIPPGNFVTLTNVRDVIASLAIMLFVCGERPSSSDVRYWPLVIRPVIADDVTCSASEPTVRIVGRNGMCVDVRDDDFHDGNQIQLWPSKSNNDPNQLWTIKRDGTIRSNGSCLTTYGYTAGVYVMIFDCNTAVREATLWEIWGNGTIINPRSNLVLAASSGIKGTTLTVQTLDYTLGQGWLAGNDTAPREVTIYGFRDLCMESNGGSVWVETCVISQQNQRWALYGDGSIRPKQNQDQCLTCGRDSVSTVINIVSCSAGSSGQRWVFTNEGAILNLKNGLAMDVAQANPKLRRIIIYPATGKPNQMWLPVP
UniProt ID: P81446
Variant: Y -> D at position 212-212
Variant annotation: in MLA'
Protein function: The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.
Reference sequence:
MNGHLASRRAWVWYFLMLGQVFGATVKAETKFSYERLRLRVTHQTTGEEYFRFITLLRDYVSSGSFSNEIPLLRQSTIPVSDAQRFVLVELTNEGGDSITAAIDVTNLYVVAYQAGDQSYFLRDAPRGAETHLFTGTTRSSLPFNGSYPDLERYAGHRDQIPLGIDQLIQSVTALRFPGGSTRTQARSILILIQMISEAARFNPILWRARQYINSGASFLPDVYMLELETSWGQQSTQVQQSTDGVFNNPIRLAIPPGNFVTLTNVRDVIASLAIMLFVCGERPSSSDVRYWPLVIRPVIADDVTCSASEPTVRIVGRNGMCVDVRDDDFHDGNQIQLWPSKSNNDPNQLWTIKRDGTIRSNGSCLTTYGYTAGVYVMIFDCNTAVREATLWEIWGNGTIINPRSNLVLAASSGIKGTTLTVQTLDYTLGQGWLAGNDTAPREVTIYGFRDLCMESNGGSVWVETCVISQQNQRWALYGDGSIRPKQNQDQCLTCGRDSVSTVINIVSCSAGSSGQRWVFTNEGAILNLKNGLAMDVAQANPKLRRIIIYPATGKPNQMWLPVP