sujigwak/NVAR huggingface dataset:
UniProt ID: Q51161
Variant: F -> Y at position 220-220
Variant annotation: in strain: 3976 / Serogroup B / Serotype NT
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGVYSQNAQTALAHAEQLLKEGADILDIGGESTRSGADYVSPEEEWARVEPVLAEVAGWGVPISLDTRRTVIMEKALALGGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKPLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANAAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
UniProt ID: Q51161
Variant: S -> R at position 230-230
Variant annotation: in strain: 952 / Serogroup B / Serotype NT and BT490 / Serogroup B / Serotype 15
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGVYSQNAQTALAHAEQLLKEGADILDIGGESTRSGADYVSPEEEWARVEPVLAEVAGWGVPISLDTRRTVIMEKALALGGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKPLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANAAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
UniProt ID: Q51161
Variant: T -> M at position 231-231
Variant annotation: in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGVYSQNAQTALAHAEQLLKEGADILDIGGESTRSGADYVSPEEEWARVEPVLAEVAGWGVPISLDTRRTVIMEKALALGGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKPLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANAAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
UniProt ID: Q51161
Variant: I -> V at position 232-232
Variant annotation: in strain: BT490 / Serogroup B / Serotype 15
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGVYSQNAQTALAHAEQLLKEGADILDIGGESTRSGADYVSPEEEWARVEPVLAEVAGWGVPISLDTRRTVIMEKALALGGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKPLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANAAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
UniProt ID: Q51161
Variant: A -> S at position 239-239
Variant annotation: in strain: BT490 / Serogroup B / Serotype 15
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGVYSQNAQTALAHAEQLLKEGADILDIGGESTRSGADYVSPEEEWARVEPVLAEVAGWGVPISLDTRRTVIMEKALALGGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKPLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANAAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
UniProt ID: Q51161
Variant: A -> T at position 239-239
Variant annotation: in strain: 3976 / Serogroup B / Serotype NT
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGVYSQNAQTALAHAEQLLKEGADILDIGGESTRSGADYVSPEEEWARVEPVLAEVAGWGVPISLDTRRTVIMEKALALGGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKPLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANAAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
UniProt ID: Q51161
Variant: N -> D at position 240-240
Variant annotation: in strain: BT490 / Serogroup B / Serotype 15, 952 / Serogroup B / Serotype NT and 3976 / Serogroup B / Serotype NT
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGVYSQNAQTALAHAEQLLKEGADILDIGGESTRSGADYVSPEEEWARVEPVLAEVAGWGVPISLDTRRTVIMEKALALGGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKPLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANAAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
UniProt ID: Q51161
Variant: E -> A at position 243-243
Variant annotation: in strain: BT490 / Serogroup B / Serotype 15 and 3976 / Serogroup B / Serotype NT
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGVYSQNAQTALAHAEQLLKEGADILDIGGESTRSGADYVSPEEEWARVEPVLAEVAGWGVPISLDTRRTVIMEKALALGGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKPLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANAAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
UniProt ID: Q51161
Variant: V -> G at position 245-245
Variant annotation: in strain: 3976 / Serogroup B / Serotype NT
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGVYSQNAQTALAHAEQLLKEGADILDIGGESTRSGADYVSPEEEWARVEPVLAEVAGWGVPISLDTRRTVIMEKALALGGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKPLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANAAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
UniProt ID: Q51161
Variant: L -> V at position 253-253
Variant annotation: in strain: BT490 / Serogroup B / Serotype 15
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGVYSQNAQTALAHAEQLLKEGADILDIGGESTRSGADYVSPEEEWARVEPVLAEVAGWGVPISLDTRRTVIMEKALALGGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKPLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANAAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
UniProt ID: Q51161
Variant: S -> A at position 255-255
Variant annotation: in strain: BT490 / Serogroup B / Serotype 15 and 3976 / Serogroup B / Serotype NT
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGVYSQNAQTALAHAEQLLKEGADILDIGGESTRSGADYVSPEEEWARVEPVLAEVAGWGVPISLDTRRTVIMEKALALGGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKPLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANAAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
UniProt ID: Q51161
Variant: Q -> K at position 261-261
Variant annotation: in strain: 3976 / Serogroup B / Serotype NT
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGVYSQNAQTALAHAEQLLKEGADILDIGGESTRSGADYVSPEEEWARVEPVLAEVAGWGVPISLDTRRTVIMEKALALGGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKPLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANAAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
UniProt ID: Q51161
Variant: V -> A at position 277-277
Variant annotation: in strain: 3976 / Serogroup B / Serotype NT
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MARHVWQAGRFEIGLDKPKIMGIVNLTPDSFSDGGVYSQNAQTALAHAEQLLKEGADILDIGGESTRSGADYVSPEEEWARVEPVLAEVAGWGVPISLDTRRTVIMEKALALGGIDIINDVAALNDEGAVELLARQADTGICLMHMQGLPKTMQINPKYQDVVGEVARYLKARSAECIAAGIAPQRIILDPGFGSGFGKPLQHNIALMRHLPELMAETGFPLLIGVSRKSTIGELTGEANAAERVHGSVAAALASVARGAQIVRVHDVKATADALKVWEALGINL
UniProt ID: Q51693
Variant: S -> N at position 400-400
Variant annotation: in strain: Pasteur
Protein function: Transpeptidase that cleaves the poly-gamma-D-glutamate capsule and catalyzes the formation of an amide bond with the side-chain amino group of meso-diaminopimelic acid (m-DAP) in the peptidoglycan scaffold . Degradation of the high-molecular weight capsule (H-capsule) to the lower-molecular weight capsule (L-capsule), which is released from the bacterial cell surface. The production of L-capsule is essential to mediate escape from host defenses.
Reference sequence:
MNSFKWGKKIILFCLIVSLMGGIGVSCSFNKIKDSVKQKIDSMGDKGTYGVSASHPLAVEEGMKVLKNGGSAVDAAIVVSYVLGVVELHASGIGGGGGMLIISKDKETFIDYRETTPYFTGNQKPHIGVPGFVAGMEYIHDNYGSLPMGELLQPAINYAEKGFKVDDSLTMRLDLAKPRIYSDKLSIFYPNGEPIETGETLIQTDLARTLKKIQKEGAKGFYEGGVARAISKTAKISLEDIKGYKVEVRKPVKGNYMGYDVYTAPPPFSGVTLLQMLKLAEKKEVYKDVDHTATYMSKMEEISRIAYQDRKKNLGDPNYVNMDPNKMVSDKYISTMKNENGDALSEAEHESTTHFVIIDRDGTVVSSTNTLSNFFGTGKYTAGFFLNNQLQNFGSEGFNSYEPGKRSRTFMAPTVLKKDGETIGIGSPGGNRIPQILTPILDKYTHGKGSLQDIINEYRFTFEKNTAYTEIQLSSEVKNELSRKGLNVKKKVSPAFFGGVQALIKDERDNVITGAGDGRRNGTWKSNK
UniProt ID: Q52126
Variant: N -> K at position 8-8
Variant annotation: in strain: BS202
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: I -> L at position 11-11
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: P -> S at position 13-13
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: A -> P at position 16-16
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: L -> M at position 36-36
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: I -> T at position 48-48
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: EN -> GS at position 58-59
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: QS -> LP at position 61-62
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: T -> V at position 65-65
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: KQ -> EH at position 67-68
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: G -> H at position 79-79
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: V -> I at position 85-85
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: A -> T at position 88-88
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: S -> A at position 121-121
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: K -> N at position 195-195
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI
UniProt ID: Q52126
Variant: S -> L at position 222-222
Variant annotation: in strain: G7
Protein function: Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-(1R,2S)-dihydroxy-1,2-dihydronaphthalene . Ferredoxin reductase catalyzes the transfer of electrons from NADH to ferredoxin (NdoA) . NADPH is also effective but yields only 39% of the activity obtained with NADH . Also able to catalyze the cis-dihydroxylation of biphenyl and phenanthrene .
Reference sequence:
MELLIQPNNRIIPFSAGANLLEVLRENGVAISYSCLSGRCGTCRCRVIDGSVIDSGAENGQSNLTDKQYVLACQSVLTGNCAIEVPEADEIVTHPARIIKGTVVAVESPTHDIRRLRVRLSKPFEFSPGQYATLQFSPEHARPYSMAGLPDDQEMEFHIRKVPGGRVTEYVFEHVREGTSIKLSGPLGTAYLRQKHTGPMLCVGGGTGLAPVLSIVRGALKSGMTNPILLYFGVRSQQDLYDAERLHKLAADHPQLTVHTVIATGPINEGQRAGLITDVIEKDILSLAGWRAYLCGAPAMVEALCTVTKHLGISPEHIYADAFYPGGI