sujigwak/NVAR huggingface dataset:
UniProt ID: P26697
Variant: AY -> VF at position 135-136
Protein function: Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity.
Reference sequence:
MAAKPVLYYFNGRGKMESIRWLLAAAGVEFEEVFLETREQYEKLLQSGILMFQQVPMVEIDGMKLVQTRAILNYIAGKYNLYGKDLKERALIDMYVGGTDDLMGFLLSFPFLSAEDKVKQCAFVVEKATSRYFPAYEKVLKDHGQDFLVGNRLSWADIHLLEAILMVEEKKSDALSGFPLLQAFKKRISSIPTIKKFLAPGSKRKPISDDKYVETVRRVLRMYYDVKPH
UniProt ID: P26697
Variant: W -> R at position 155-155
Protein function: Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity.
Reference sequence:
MAAKPVLYYFNGRGKMESIRWLLAAAGVEFEEVFLETREQYEKLLQSGILMFQQVPMVEIDGMKLVQTRAILNYIAGKYNLYGKDLKERALIDMYVGGTDDLMGFLLSFPFLSAEDKVKQCAFVVEKATSRYFPAYEKVLKDHGQDFLVGNRLSWADIHLLEAILMVEEKKSDALSGFPLLQAFKKRISSIPTIKKFLAPGSKRKPISDDKYVETVRRVLRMYYDVKPH
UniProt ID: P26697
Variant: IH -> VV at position 158-159
Protein function: Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity.
Reference sequence:
MAAKPVLYYFNGRGKMESIRWLLAAAGVEFEEVFLETREQYEKLLQSGILMFQQVPMVEIDGMKLVQTRAILNYIAGKYNLYGKDLKERALIDMYVGGTDDLMGFLLSFPFLSAEDKVKQCAFVVEKATSRYFPAYEKVLKDHGQDFLVGNRLSWADIHLLEAILMVEEKKSDALSGFPLLQAFKKRISSIPTIKKFLAPGSKRKPISDDKYVETVRRVLRMYYDVKPH
UniProt ID: P26697
Variant: A -> T at position 163-163
Protein function: Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity.
Reference sequence:
MAAKPVLYYFNGRGKMESIRWLLAAAGVEFEEVFLETREQYEKLLQSGILMFQQVPMVEIDGMKLVQTRAILNYIAGKYNLYGKDLKERALIDMYVGGTDDLMGFLLSFPFLSAEDKVKQCAFVVEKATSRYFPAYEKVLKDHGQDFLVGNRLSWADIHLLEAILMVEEKKSDALSGFPLLQAFKKRISSIPTIKKFLAPGSKRKPISDDKYVETVRRVLRMYYDVKPH
UniProt ID: P26697
Variant: M -> A at position 166-166
Protein function: Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity.
Reference sequence:
MAAKPVLYYFNGRGKMESIRWLLAAAGVEFEEVFLETREQYEKLLQSGILMFQQVPMVEIDGMKLVQTRAILNYIAGKYNLYGKDLKERALIDMYVGGTDDLMGFLLSFPFLSAEDKVKQCAFVVEKATSRYFPAYEKVLKDHGQDFLVGNRLSWADIHLLEAILMVEEKKSDALSGFPLLQAFKKRISSIPTIKKFLAPGSKRKPISDDKYVETVRRVLRMYYDVKPH
UniProt ID: P26697
Variant: E -> V at position 168-168
Protein function: Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity.
Reference sequence:
MAAKPVLYYFNGRGKMESIRWLLAAAGVEFEEVFLETREQYEKLLQSGILMFQQVPMVEIDGMKLVQTRAILNYIAGKYNLYGKDLKERALIDMYVGGTDDLMGFLLSFPFLSAEDKVKQCAFVVEKATSRYFPAYEKVLKDHGQDFLVGNRLSWADIHLLEAILMVEEKKSDALSGFPLLQAFKKRISSIPTIKKFLAPGSKRKPISDDKYVETVRRVLRMYYDVKPH
UniProt ID: P26718
Variant: T -> A at position 72-72
Variant annotation: in dbSNP:rs2255336
Protein function: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Reference sequence:
MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCRENASPFFFCCFIAVAMGIRFIIMVTIWSAVFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV
UniProt ID: P26718
Variant: N -> S at position 177-177
Variant annotation: in dbSNP:rs2306182
Protein function: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Reference sequence:
MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCRENASPFFFCCFIAVAMGIRFIIMVTIWSAVFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV
UniProt ID: P26731
Variant: L -> F at position 11-11
Protein function: Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.
Reference sequence:
MKLLLTIALMLSTVMWVSTQQPQEVHTYCGRHLARTMADLCWEAGVDKRSDAQFASYGSAWLMPYSAGRGIVDECCLRPCSVDVLLSYC
UniProt ID: P26736
Variant: G -> R at position 23-23
Variant annotation: in strain: Kinshu
Protein function: Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.
Reference sequence:
MKLLGFFLSWVSVCAIVSASEEGHIYCGRYLAYKMADLCWRAGFEKRSVAHYAGYGWPLLPSLSEERGKRGIADECCLQPCTNDVLLSYC
UniProt ID: P26741
Variant: M -> I at position 17-17
Variant annotation: in strain: Showa
Protein function: Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.
Reference sequence:
MMKTSVMLMLVVVISLMCSGEAQEVARTYCGRHLADTLADLCFGVEKRGGAQYAPYFWTRQYLGSRGKRGVVDECCFRPCTLDVLLSYCG
UniProt ID: P26741
Variant: G -> S at position 49-49
Variant annotation: in strain: Showa
Protein function: Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.
Reference sequence:
MMKTSVMLMLVVVISLMCSGEAQEVARTYCGRHLADTLADLCFGVEKRGGAQYAPYFWTRQYLGSRGKRGVVDECCFRPCTLDVLLSYCG
UniProt ID: P26741
Variant: Y -> H at position 62-62
Variant annotation: in strain: Showa
Protein function: Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.
Reference sequence:
MMKTSVMLMLVVVISLMCSGEAQEVARTYCGRHLADTLADLCFGVEKRGGAQYAPYFWTRQYLGSRGKRGVVDECCFRPCTLDVLLSYCG
UniProt ID: P26741
Variant: S -> N at position 65-65
Variant annotation: in strain: Showa
Protein function: Brain peptide responsible for activation of prothoracic glands to produce ecdysone in insects.
Reference sequence:
MMKTSVMLMLVVVISLMCSGEAQEVARTYCGRHLADTLADLCFGVEKRGGAQYAPYFWTRQYLGSRGKRGVVDECCFRPCTLDVLLSYCG
UniProt ID: P26760
Variant: EQA -> KQT at position 110-112
Variant annotation: in strain: Serotype 5
Protein function: Involved in the transport of the toxin RTX-I as well as that of RTX-II.
Reference sequence:
MDFYREEDYGLYALTILAQYHNIAVNPEELKHKFDLEGKGLDLTAWLLAAKSLELKAKQVKKAIDRLAFIALPALVWREDGKHFILTKIDNEAKKYLIFDLETHNPRILEQAEFESLYQGKLILVASRASIVGKLAKFDFTWFIPAVIKYRKIFIETLIVSIFLQIFALITPLFFQVVMDKVLVHRGFSTLNVITVALAIVVLFEIVLNGLRTYIFAHSTSRIDVELGARLFRHLLALPISYFENRRVGDTVARVRELDQIRNFLTGQALTSVLDLMFSFIFFAVMWYYSPKLTLVILGSLPFYMGWSIFISPILRRRLDEKFARGADNQSFLVESVTAINTIKALAVTPQMTNTWDKQLASYVSAGFRVTTLATIGQQGVQFIQKVVMVITLWLGAHLVISGDLSIGQLIAFNMLSGQVIAPVIRLAQLWQDFQQVGISVTRLGDVLNSPTESYQGKLALPEIKGDITFRNIRFRYKPDAPVILNDVNLSIQQGEVIGIVGRSGSGKSTLTKLIQRFYIPENGQVLIDGHDLALADPNWLRRQVGVVLQDNVLLNRSIRDNIALADPGMPMEKIVHAAKLAGAHEFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHIIMRNMHQICKGRTVIIIAHRLSTVKNADRIIVMEKGQIVEQGKHKELLADPNGLYHYLHQLQSE
UniProt ID: P26760
Variant: D -> H at position 328-328
Variant annotation: in strain: Serotype 5
Protein function: Involved in the transport of the toxin RTX-I as well as that of RTX-II.
Reference sequence:
MDFYREEDYGLYALTILAQYHNIAVNPEELKHKFDLEGKGLDLTAWLLAAKSLELKAKQVKKAIDRLAFIALPALVWREDGKHFILTKIDNEAKKYLIFDLETHNPRILEQAEFESLYQGKLILVASRASIVGKLAKFDFTWFIPAVIKYRKIFIETLIVSIFLQIFALITPLFFQVVMDKVLVHRGFSTLNVITVALAIVVLFEIVLNGLRTYIFAHSTSRIDVELGARLFRHLLALPISYFENRRVGDTVARVRELDQIRNFLTGQALTSVLDLMFSFIFFAVMWYYSPKLTLVILGSLPFYMGWSIFISPILRRRLDEKFARGADNQSFLVESVTAINTIKALAVTPQMTNTWDKQLASYVSAGFRVTTLATIGQQGVQFIQKVVMVITLWLGAHLVISGDLSIGQLIAFNMLSGQVIAPVIRLAQLWQDFQQVGISVTRLGDVLNSPTESYQGKLALPEIKGDITFRNIRFRYKPDAPVILNDVNLSIQQGEVIGIVGRSGSGKSTLTKLIQRFYIPENGQVLIDGHDLALADPNWLRRQVGVVLQDNVLLNRSIRDNIALADPGMPMEKIVHAAKLAGAHEFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHIIMRNMHQICKGRTVIIIAHRLSTVKNADRIIVMEKGQIVEQGKHKELLADPNGLYHYLHQLQSE
UniProt ID: P26760
Variant: R -> V at position 517-517
Variant annotation: in strain: Serotype 5
Protein function: Involved in the transport of the toxin RTX-I as well as that of RTX-II.
Reference sequence:
MDFYREEDYGLYALTILAQYHNIAVNPEELKHKFDLEGKGLDLTAWLLAAKSLELKAKQVKKAIDRLAFIALPALVWREDGKHFILTKIDNEAKKYLIFDLETHNPRILEQAEFESLYQGKLILVASRASIVGKLAKFDFTWFIPAVIKYRKIFIETLIVSIFLQIFALITPLFFQVVMDKVLVHRGFSTLNVITVALAIVVLFEIVLNGLRTYIFAHSTSRIDVELGARLFRHLLALPISYFENRRVGDTVARVRELDQIRNFLTGQALTSVLDLMFSFIFFAVMWYYSPKLTLVILGSLPFYMGWSIFISPILRRRLDEKFARGADNQSFLVESVTAINTIKALAVTPQMTNTWDKQLASYVSAGFRVTTLATIGQQGVQFIQKVVMVITLWLGAHLVISGDLSIGQLIAFNMLSGQVIAPVIRLAQLWQDFQQVGISVTRLGDVLNSPTESYQGKLALPEIKGDITFRNIRFRYKPDAPVILNDVNLSIQQGEVIGIVGRSGSGKSTLTKLIQRFYIPENGQVLIDGHDLALADPNWLRRQVGVVLQDNVLLNRSIRDNIALADPGMPMEKIVHAAKLAGAHEFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHIIMRNMHQICKGRTVIIIAHRLSTVKNADRIIVMEKGQIVEQGKHKELLADPNGLYHYLHQLQSE
UniProt ID: P26760
Variant: N -> G at position 556-556
Variant annotation: in strain: Serotype 5
Protein function: Involved in the transport of the toxin RTX-I as well as that of RTX-II.
Reference sequence:
MDFYREEDYGLYALTILAQYHNIAVNPEELKHKFDLEGKGLDLTAWLLAAKSLELKAKQVKKAIDRLAFIALPALVWREDGKHFILTKIDNEAKKYLIFDLETHNPRILEQAEFESLYQGKLILVASRASIVGKLAKFDFTWFIPAVIKYRKIFIETLIVSIFLQIFALITPLFFQVVMDKVLVHRGFSTLNVITVALAIVVLFEIVLNGLRTYIFAHSTSRIDVELGARLFRHLLALPISYFENRRVGDTVARVRELDQIRNFLTGQALTSVLDLMFSFIFFAVMWYYSPKLTLVILGSLPFYMGWSIFISPILRRRLDEKFARGADNQSFLVESVTAINTIKALAVTPQMTNTWDKQLASYVSAGFRVTTLATIGQQGVQFIQKVVMVITLWLGAHLVISGDLSIGQLIAFNMLSGQVIAPVIRLAQLWQDFQQVGISVTRLGDVLNSPTESYQGKLALPEIKGDITFRNIRFRYKPDAPVILNDVNLSIQQGEVIGIVGRSGSGKSTLTKLIQRFYIPENGQVLIDGHDLALADPNWLRRQVGVVLQDNVLLNRSIRDNIALADPGMPMEKIVHAAKLAGAHEFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHIIMRNMHQICKGRTVIIIAHRLSTVKNADRIIVMEKGQIVEQGKHKELLADPNGLYHYLHQLQSE
UniProt ID: P26760
Variant: GQR -> RAT at position 609-611
Variant annotation: in strain: S 4074 / Serotype 1
Protein function: Involved in the transport of the toxin RTX-I as well as that of RTX-II.
Reference sequence:
MDFYREEDYGLYALTILAQYHNIAVNPEELKHKFDLEGKGLDLTAWLLAAKSLELKAKQVKKAIDRLAFIALPALVWREDGKHFILTKIDNEAKKYLIFDLETHNPRILEQAEFESLYQGKLILVASRASIVGKLAKFDFTWFIPAVIKYRKIFIETLIVSIFLQIFALITPLFFQVVMDKVLVHRGFSTLNVITVALAIVVLFEIVLNGLRTYIFAHSTSRIDVELGARLFRHLLALPISYFENRRVGDTVARVRELDQIRNFLTGQALTSVLDLMFSFIFFAVMWYYSPKLTLVILGSLPFYMGWSIFISPILRRRLDEKFARGADNQSFLVESVTAINTIKALAVTPQMTNTWDKQLASYVSAGFRVTTLATIGQQGVQFIQKVVMVITLWLGAHLVISGDLSIGQLIAFNMLSGQVIAPVIRLAQLWQDFQQVGISVTRLGDVLNSPTESYQGKLALPEIKGDITFRNIRFRYKPDAPVILNDVNLSIQQGEVIGIVGRSGSGKSTLTKLIQRFYIPENGQVLIDGHDLALADPNWLRRQVGVVLQDNVLLNRSIRDNIALADPGMPMEKIVHAAKLAGAHEFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHIIMRNMHQICKGRTVIIIAHRLSTVKNADRIIVMEKGQIVEQGKHKELLADPNGLYHYLHQLQSE
UniProt ID: P26760
Variant: RQ -> PN at position 611-612
Variant annotation: in strain: Serotype 5
Protein function: Involved in the transport of the toxin RTX-I as well as that of RTX-II.
Reference sequence:
MDFYREEDYGLYALTILAQYHNIAVNPEELKHKFDLEGKGLDLTAWLLAAKSLELKAKQVKKAIDRLAFIALPALVWREDGKHFILTKIDNEAKKYLIFDLETHNPRILEQAEFESLYQGKLILVASRASIVGKLAKFDFTWFIPAVIKYRKIFIETLIVSIFLQIFALITPLFFQVVMDKVLVHRGFSTLNVITVALAIVVLFEIVLNGLRTYIFAHSTSRIDVELGARLFRHLLALPISYFENRRVGDTVARVRELDQIRNFLTGQALTSVLDLMFSFIFFAVMWYYSPKLTLVILGSLPFYMGWSIFISPILRRRLDEKFARGADNQSFLVESVTAINTIKALAVTPQMTNTWDKQLASYVSAGFRVTTLATIGQQGVQFIQKVVMVITLWLGAHLVISGDLSIGQLIAFNMLSGQVIAPVIRLAQLWQDFQQVGISVTRLGDVLNSPTESYQGKLALPEIKGDITFRNIRFRYKPDAPVILNDVNLSIQQGEVIGIVGRSGSGKSTLTKLIQRFYIPENGQVLIDGHDLALADPNWLRRQVGVVLQDNVLLNRSIRDNIALADPGMPMEKIVHAAKLAGAHEFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHIIMRNMHQICKGRTVIIIAHRLSTVKNADRIIVMEKGQIVEQGKHKELLADPNGLYHYLHQLQSE
UniProt ID: P26760
Variant: DR -> AS at position 671-672
Variant annotation: in strain: Serotype 5
Protein function: Involved in the transport of the toxin RTX-I as well as that of RTX-II.
Reference sequence:
MDFYREEDYGLYALTILAQYHNIAVNPEELKHKFDLEGKGLDLTAWLLAAKSLELKAKQVKKAIDRLAFIALPALVWREDGKHFILTKIDNEAKKYLIFDLETHNPRILEQAEFESLYQGKLILVASRASIVGKLAKFDFTWFIPAVIKYRKIFIETLIVSIFLQIFALITPLFFQVVMDKVLVHRGFSTLNVITVALAIVVLFEIVLNGLRTYIFAHSTSRIDVELGARLFRHLLALPISYFENRRVGDTVARVRELDQIRNFLTGQALTSVLDLMFSFIFFAVMWYYSPKLTLVILGSLPFYMGWSIFISPILRRRLDEKFARGADNQSFLVESVTAINTIKALAVTPQMTNTWDKQLASYVSAGFRVTTLATIGQQGVQFIQKVVMVITLWLGAHLVISGDLSIGQLIAFNMLSGQVIAPVIRLAQLWQDFQQVGISVTRLGDVLNSPTESYQGKLALPEIKGDITFRNIRFRYKPDAPVILNDVNLSIQQGEVIGIVGRSGSGKSTLTKLIQRFYIPENGQVLIDGHDLALADPNWLRRQVGVVLQDNVLLNRSIRDNIALADPGMPMEKIVHAAKLAGAHEFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHIIMRNMHQICKGRTVIIIAHRLSTVKNADRIIVMEKGQIVEQGKHKELLADPNGLYHYLHQLQSE
UniProt ID: P26760
Variant: A -> R at position 692-692
Variant annotation: in strain: Serotype 5
Protein function: Involved in the transport of the toxin RTX-I as well as that of RTX-II.
Reference sequence:
MDFYREEDYGLYALTILAQYHNIAVNPEELKHKFDLEGKGLDLTAWLLAAKSLELKAKQVKKAIDRLAFIALPALVWREDGKHFILTKIDNEAKKYLIFDLETHNPRILEQAEFESLYQGKLILVASRASIVGKLAKFDFTWFIPAVIKYRKIFIETLIVSIFLQIFALITPLFFQVVMDKVLVHRGFSTLNVITVALAIVVLFEIVLNGLRTYIFAHSTSRIDVELGARLFRHLLALPISYFENRRVGDTVARVRELDQIRNFLTGQALTSVLDLMFSFIFFAVMWYYSPKLTLVILGSLPFYMGWSIFISPILRRRLDEKFARGADNQSFLVESVTAINTIKALAVTPQMTNTWDKQLASYVSAGFRVTTLATIGQQGVQFIQKVVMVITLWLGAHLVISGDLSIGQLIAFNMLSGQVIAPVIRLAQLWQDFQQVGISVTRLGDVLNSPTESYQGKLALPEIKGDITFRNIRFRYKPDAPVILNDVNLSIQQGEVIGIVGRSGSGKSTLTKLIQRFYIPENGQVLIDGHDLALADPNWLRRQVGVVLQDNVLLNRSIRDNIALADPGMPMEKIVHAAKLAGAHEFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHIIMRNMHQICKGRTVIIIAHRLSTVKNADRIIVMEKGQIVEQGKHKELLADPNGLYHYLHQLQSE
UniProt ID: P26761
Variant: A -> R at position 14-14
Variant annotation: in strain: S 4074 / Serotype 1 and Isolate CVI 13261 / Serotype 9
Protein function: Involved in the transport of the toxin RTX-I as well as that of RTX-II.
Reference sequence:
MKTWLMGLYEFFQAYKTVWTEIWKIRHQLDTPDREKDENEFLPAHLELIETPVSKKPRLIAYLIMLFLFLALVISIVSHVEIVATATGKLAFSGRSKEIKPIENALVKEIFVEDGQFVEKDQLLLHLTALGADADQQKTKSSLSLTKLERYRYEILLEAVAADRLPLIELTKDEFKHATEEDKTRIRYLITEQFEAWQKQKYQKELALQRREAEKQTVLANIRKYEGSSRVENERLKDLKKLFNSKSTSKHDVLTQENRHIEAVNELAVYKSRLNEVESDLRQAKEEIHLITQLFRADILEKLKQNVEAEKQLSLELEKNEQRQIASVIRAPVSYVQQLKTHTVGGVVTTAETLMVIAPEDDVLEVTALIQNKDIGFIEVGQDAVIKVETFPYTRYGYLMGKVKNITLEAIEHPQLGLVFNSIISIDRKTLSGKDGKEIELGSGMSVTAEIKTGERSVISYLLSPLEESVSESLRER
UniProt ID: P26761
Variant: G -> D at position 94-94
Variant annotation: in strain: S 4074 / Serotype 1 and Isolate CVI 13261 / Serotype 9
Protein function: Involved in the transport of the toxin RTX-I as well as that of RTX-II.
Reference sequence:
MKTWLMGLYEFFQAYKTVWTEIWKIRHQLDTPDREKDENEFLPAHLELIETPVSKKPRLIAYLIMLFLFLALVISIVSHVEIVATATGKLAFSGRSKEIKPIENALVKEIFVEDGQFVEKDQLLLHLTALGADADQQKTKSSLSLTKLERYRYEILLEAVAADRLPLIELTKDEFKHATEEDKTRIRYLITEQFEAWQKQKYQKELALQRREAEKQTVLANIRKYEGSSRVENERLKDLKKLFNSKSTSKHDVLTQENRHIEAVNELAVYKSRLNEVESDLRQAKEEIHLITQLFRADILEKLKQNVEAEKQLSLELEKNEQRQIASVIRAPVSYVQQLKTHTVGGVVTTAETLMVIAPEDDVLEVTALIQNKDIGFIEVGQDAVIKVETFPYTRYGYLMGKVKNITLEAIEHPQLGLVFNSIISIDRKTLSGKDGKEIELGSGMSVTAEIKTGERSVISYLLSPLEESVSESLRER
UniProt ID: P26761
Variant: E -> Q at position 113-113
Variant annotation: in strain: S 4074 / Serotype 1 and Isolate CVI 13261 / Serotype 9
Protein function: Involved in the transport of the toxin RTX-I as well as that of RTX-II.
Reference sequence:
MKTWLMGLYEFFQAYKTVWTEIWKIRHQLDTPDREKDENEFLPAHLELIETPVSKKPRLIAYLIMLFLFLALVISIVSHVEIVATATGKLAFSGRSKEIKPIENALVKEIFVEDGQFVEKDQLLLHLTALGADADQQKTKSSLSLTKLERYRYEILLEAVAADRLPLIELTKDEFKHATEEDKTRIRYLITEQFEAWQKQKYQKELALQRREAEKQTVLANIRKYEGSSRVENERLKDLKKLFNSKSTSKHDVLTQENRHIEAVNELAVYKSRLNEVESDLRQAKEEIHLITQLFRADILEKLKQNVEAEKQLSLELEKNEQRQIASVIRAPVSYVQQLKTHTVGGVVTTAETLMVIAPEDDVLEVTALIQNKDIGFIEVGQDAVIKVETFPYTRYGYLMGKVKNITLEAIEHPQLGLVFNSIISIDRKTLSGKDGKEIELGSGMSVTAEIKTGERSVISYLLSPLEESVSESLRER
UniProt ID: P26761
Variant: S -> I at position 228-228
Variant annotation: in strain: S 4074 / Serotype 1 and Isolate CVI 13261 / Serotype 9
Protein function: Involved in the transport of the toxin RTX-I as well as that of RTX-II.
Reference sequence:
MKTWLMGLYEFFQAYKTVWTEIWKIRHQLDTPDREKDENEFLPAHLELIETPVSKKPRLIAYLIMLFLFLALVISIVSHVEIVATATGKLAFSGRSKEIKPIENALVKEIFVEDGQFVEKDQLLLHLTALGADADQQKTKSSLSLTKLERYRYEILLEAVAADRLPLIELTKDEFKHATEEDKTRIRYLITEQFEAWQKQKYQKELALQRREAEKQTVLANIRKYEGSSRVENERLKDLKKLFNSKSTSKHDVLTQENRHIEAVNELAVYKSRLNEVESDLRQAKEEIHLITQLFRADILEKLKQNVEAEKQLSLELEKNEQRQIASVIRAPVSYVQQLKTHTVGGVVTTAETLMVIAPEDDVLEVTALIQNKDIGFIEVGQDAVIKVETFPYTRYGYLMGKVKNITLEAIEHPQLGLVFNSIISIDRKTLSGKDGKEIELGSGMSVTAEIKTGERSVISYLLSPLEESVSESLRER
UniProt ID: P26761
Variant: Y -> GT at position 335-335
Variant annotation: in strain: S 4074 / Serotype 1 and Isolate CVI 13261 / Serotype 9
Protein function: Involved in the transport of the toxin RTX-I as well as that of RTX-II.
Reference sequence:
MKTWLMGLYEFFQAYKTVWTEIWKIRHQLDTPDREKDENEFLPAHLELIETPVSKKPRLIAYLIMLFLFLALVISIVSHVEIVATATGKLAFSGRSKEIKPIENALVKEIFVEDGQFVEKDQLLLHLTALGADADQQKTKSSLSLTKLERYRYEILLEAVAADRLPLIELTKDEFKHATEEDKTRIRYLITEQFEAWQKQKYQKELALQRREAEKQTVLANIRKYEGSSRVENERLKDLKKLFNSKSTSKHDVLTQENRHIEAVNELAVYKSRLNEVESDLRQAKEEIHLITQLFRADILEKLKQNVEAEKQLSLELEKNEQRQIASVIRAPVSYVQQLKTHTVGGVVTTAETLMVIAPEDDVLEVTALIQNKDIGFIEVGQDAVIKVETFPYTRYGYLMGKVKNITLEAIEHPQLGLVFNSIISIDRKTLSGKDGKEIELGSGMSVTAEIKTGERSVISYLLSPLEESVSESLRER
UniProt ID: P26779
Variant: H -> R at position 127-127
Protein function: Saposins are specific low-molecular mass non-enzymatic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
Reference sequence:
MYSFFVLASLLGGALASPVLGLRECTRGSAVWCQNVKTAADCGAVQHCLQTVWSKPTVKSLPCDICKDVITAAGNLLKDNATEQEILMYLERTCDWLPKPNMSASCKEIVDSYLPVILDMIKGQMSHPGEVCSALNLCESLQKHLAELNHQKQLESNQIPELDMAEVVAPFMANIPFLLYPQDGSHSKPQPKKANGNVCQDCIQLVTDVQEALRTNSTFVEALVDHAKEECDRLGPGMSDMCKNYINQYSEVAIQMVMHMQPKEICVLAGFCDEVKEMPMKTLVPAEVVSENVIPALGLVEPIKKDPAPAKADIYCEVCEFVVKEVAKLIDNNRTEEEILHALDKVCSKLPTSLAEQCQEVVDTYGSSILSILLDEASPELVCSMLHLCSSRGLPAATVRVMPRKDGGFCEVCKKLVGYLDRNLEKNSTKEQILAALEKGCSFLPDQYRKQCDQFVTEYEPVLIEILVEVMDPSFVCLKIGACPAAHKPLLGAEKCVWGPSYWCQNMESAALCNAVEHCRRHVWN
UniProt ID: P26831
Variant: G -> A at position 147-147
Variant annotation: in strain: CPN50
Protein function: Putative virulence factor which is likely to act on connective tissue during gas gangrene.
Reference sequence:
MNKNIRKIITSTVLAAMTISVLPSNLVVFATDGITENFYEIYPKPQEISYSGGEFQISDEINIVYDDGIDTYTKKRVDEVLEASNLEATVSNEIVPGKTNFLVGINESGGVVDNYFNKNIPHDESFFDEKMDANIVSVKDGVIGVIGEDTDSAFYGVTTLKHVFNQLEEGNKIQSFRADDYAEVAHRGFIEGYYGNPWSNEDRAELMKFGGDYKLNQYVFAPKDDPYHNSKWRDLYPEEKLSEIKKLAQVGNETKNRYVYALHPFMNNPVRFDTEENYQNDLGVIKAKFTQLLENDVRQFAILADDASAPAQGASMYVKLLTDLTRWLEEQQSTYPDLKTDLMFCPSDYYGNGSSAQLKELNKAEDNVSIVMTGGRIWGEVDENFANNFMNNISTEGHPGRAPFFWINWPCSDNSKQHLIMGGNDTFLHPGVDPSKIDGIVLNPMQQAEANKSALFAIADYAWNIWDNKEEADENWNDSFKYMDHGTAEETNSSLALREISKHMINQNMDGRVRPLQESVELAPKLEAFKQKYDSGASIKEDALELIAEFTNLQKAADYYKNNPGNERTRDQIIYWLNCWEDTMDAAIGYLKSAIAIEEGDDEAAWANYSEAQGAFEKSKTYGFHYVDHTEYAEVGVQHIVPFIKSMGQNLSVVIGSIVDPNRIIATYISNRQDAPTGNPDNIFDNNASTELVYKNPNRIDVGTYVGVKYSNPITLNNVEFLMGANSNPNDTMQKAKIQYTVDGREWIDLEEGVEYTMPGAIKVENLDLKVRGVRLIATEARENTWLGVRDINVNKKEDSNSGVEFNPSLIRSESWQVYEGNEANLLDGDDNTGVWYKTLNGDTSLAGEFIGLDLGKEIKLDGIRFVIGKNGGGSSDKWNKFKLEYSLDNESWTTIKEYDKTGAPAGKDVIEESFETPISAKYIRLTNMENINKWLTFSEFAIISDELENAGNKENVYTNTELDLLSLAKEDVTKLIPTDDISLNHGEYIGVKLNRIKDLSNINLEISNDTGLKLQSSMNGVEWTEITDKNTLEDGRYVRLINTSNEAVNFNLTKFEVNSNEVYEPSLVDAYVGDDGAKKAVDGDLKTRVKFLGAPSTGDTIVYDLGQEILVDNLKYVVLDTEVDHVRDGKIQLSLDGETWTDAITIGDGVENGVDDMFSTPLKNGYKHGNQSGGIVPIDSAYVEGDNLNQKARYVRILFTAPYRHRWTVINELMINNGEYISTVNDPTYISNPIEERGFAPSNLRDGNLTTSYKPNTNNGEISEGSITYRLSEKTDVRKVTIVQSGSSISNAKVMARVGDGSENVTDQWVQLGTLSNSLNEFINRDYNNIYEIKIEWTDVAPNIYEIITLNQEFEFPVNDSLKAKYDELINLSGDEYTLSSFETLKEALNEAKSILDDSNSSQKKIDKALEKLNKAEERLDLRATDFEDFNKVLTLGNSLVEEEYTAESWALFSEVLEAANEANKNKADYTQDQINQIVIDLDASIKALVKETPEVDKTNLGELINQGKSLLDESVEGFNVGEYHKGAKDGLTVEINKAEEVFNKEDATEEEINLAKESLEGAIARFNSLLIEESTGDFNGNGKIDIGDLAMVSKNIGSTTNTSLDLNKDGSIDEYEISFINHRILN
UniProt ID: P26831
Variant: KIQS -> EIKN at position 172-175
Variant annotation: in strain: CPN50
Protein function: Putative virulence factor which is likely to act on connective tissue during gas gangrene.
Reference sequence:
MNKNIRKIITSTVLAAMTISVLPSNLVVFATDGITENFYEIYPKPQEISYSGGEFQISDEINIVYDDGIDTYTKKRVDEVLEASNLEATVSNEIVPGKTNFLVGINESGGVVDNYFNKNIPHDESFFDEKMDANIVSVKDGVIGVIGEDTDSAFYGVTTLKHVFNQLEEGNKIQSFRADDYAEVAHRGFIEGYYGNPWSNEDRAELMKFGGDYKLNQYVFAPKDDPYHNSKWRDLYPEEKLSEIKKLAQVGNETKNRYVYALHPFMNNPVRFDTEENYQNDLGVIKAKFTQLLENDVRQFAILADDASAPAQGASMYVKLLTDLTRWLEEQQSTYPDLKTDLMFCPSDYYGNGSSAQLKELNKAEDNVSIVMTGGRIWGEVDENFANNFMNNISTEGHPGRAPFFWINWPCSDNSKQHLIMGGNDTFLHPGVDPSKIDGIVLNPMQQAEANKSALFAIADYAWNIWDNKEEADENWNDSFKYMDHGTAEETNSSLALREISKHMINQNMDGRVRPLQESVELAPKLEAFKQKYDSGASIKEDALELIAEFTNLQKAADYYKNNPGNERTRDQIIYWLNCWEDTMDAAIGYLKSAIAIEEGDDEAAWANYSEAQGAFEKSKTYGFHYVDHTEYAEVGVQHIVPFIKSMGQNLSVVIGSIVDPNRIIATYISNRQDAPTGNPDNIFDNNASTELVYKNPNRIDVGTYVGVKYSNPITLNNVEFLMGANSNPNDTMQKAKIQYTVDGREWIDLEEGVEYTMPGAIKVENLDLKVRGVRLIATEARENTWLGVRDINVNKKEDSNSGVEFNPSLIRSESWQVYEGNEANLLDGDDNTGVWYKTLNGDTSLAGEFIGLDLGKEIKLDGIRFVIGKNGGGSSDKWNKFKLEYSLDNESWTTIKEYDKTGAPAGKDVIEESFETPISAKYIRLTNMENINKWLTFSEFAIISDELENAGNKENVYTNTELDLLSLAKEDVTKLIPTDDISLNHGEYIGVKLNRIKDLSNINLEISNDTGLKLQSSMNGVEWTEITDKNTLEDGRYVRLINTSNEAVNFNLTKFEVNSNEVYEPSLVDAYVGDDGAKKAVDGDLKTRVKFLGAPSTGDTIVYDLGQEILVDNLKYVVLDTEVDHVRDGKIQLSLDGETWTDAITIGDGVENGVDDMFSTPLKNGYKHGNQSGGIVPIDSAYVEGDNLNQKARYVRILFTAPYRHRWTVINELMINNGEYISTVNDPTYISNPIEERGFAPSNLRDGNLTTSYKPNTNNGEISEGSITYRLSEKTDVRKVTIVQSGSSISNAKVMARVGDGSENVTDQWVQLGTLSNSLNEFINRDYNNIYEIKIEWTDVAPNIYEIITLNQEFEFPVNDSLKAKYDELINLSGDEYTLSSFETLKEALNEAKSILDDSNSSQKKIDKALEKLNKAEERLDLRATDFEDFNKVLTLGNSLVEEEYTAESWALFSEVLEAANEANKNKADYTQDQINQIVIDLDASIKALVKETPEVDKTNLGELINQGKSLLDESVEGFNVGEYHKGAKDGLTVEINKAEEVFNKEDATEEEINLAKESLEGAIARFNSLLIEESTGDFNGNGKIDIGDLAMVSKNIGSTTNTSLDLNKDGSIDEYEISFINHRILN