sujigwak/NVAR huggingface dataset:
UniProt ID: Q9CAE3
Variant: R -> L at position 686-686
Variant annotation: in strain: cv. Lz-0
Protein function: Probable histone demethylase that promotes flowering independently of the photoperiod and vernalization pathways by repressing FLOWERING LOCUS C (FLC), a floral repressor that blocks the transition from vegetative to reproductive development. Probably mediates histone H3 'Lys-4' demethylation at FLC locus. Seems to act in partial redundancy with LDL1 and LDL2 to repress FLC expression. Required for histone H4 deacetylation of FLC locus. May be a component of the histone deacetylase complex. Forms a histone deacetylase complex with HDA5, HDA6 and MSI4/FVE that represses FLC gene expression to control flowering time . Required for systemic acquired resistance (SAR) toward pathogenic bacteria (e.g. Pseudomonas syringae pv tomato DC3000 (avrPto)) . Together with FLD and MSI4/FVE, contributes to dehydroabietinal-dependent (DA, a diterpenoid tricyclic diterpene) activation of flowering ans SAR .
Reference sequence:
MVSFSAPKKRRRGRSQRSMSSLNSLPVPNVGLLPGNSNFVSSSASSSGRFNVEVVNGSNQTVKSYPGIGDEIITINKEATTEALLALTAGFPADSLTEEEIEFGVVPIVGGIEQVNYILIRNHIISKWRENISSWVTKEMFLNSIPKHCSSLLDSAYNYLVTHGYINFGIAQAIKDKFPAQSSKSSVIIVGAGLSGLAAARQLMRFGFKVTVLEGRKRPGGRVYTKKMEANRVGAAADLGGSVLTGTLGNPLGIIARQLGSSLYKVRDKCPLYRVDGKPVDPDVDIKVEVAFNQLLDKASKLRQLMGDVSMDVSLGAALETFRQVSGNDVATEEMGLFNWHLANLEYANAGLVSKLSLAFWDQDDPYDMGGDHCFLPGGNGRLVQALAENVPILYEKTVQTIRYGSNGVKVTAGNQVYEGDMVLCTVPLGVLKNGSIKFVPELPQRKLDCIKRLGFGLLNKVAMLFPYVFWSTDLDTFGHLTEDPNYRGEFFLFYSYAPVAGGALLIALVAGEAAHKFETMPPTDAVTRVLHILRGIYEPQGINVPDPLQTVCTRWGGDPFSLGSYSNVAVGASGDDYDILAESVGDGRLFFAGEATTRRYPATMHGAFVTGLREAANMAQSAKARGIRKRIDRNPSRNAHSCAILLADLFRDPDLEFGSFCIIFSRRNPDPKSPAILRVTLSEPRKRNEDPKADQHSNKILFQQLQSHFNQQQQIQVYTLLTRQQALDLREVRGGDEKRLYYLCETLGVKLVGRKGLGVGADSVIASIKAERTGRKLPSSSTSGTKSG
UniProt ID: Q9CNC4
Variant: M -> T at position 25-25
Variant annotation: in strain: ATCC 15742 / P1059
Protein function: Catalyzes the transfer of sialic acid from the substrate CMP-N-acetylneuraminate to lactosyl lipids as preferred acceptor substrates in vitro, forming alpha-2,3-linked sialosides. Beta-1,4-linked galactosyl lipids are better substrates than beta-1,3-linked galactosyl lipids. The natural acceptor substrate may be cell surface oligosaccharides in lipooligosaccharide (LOS), whose sialylation has been demonstrated vital for the virulence of P.multocida.
Reference sequence:
MNLIICCTPLQVLIAEKIIAKFPHMPFYGVMLSTVSNKKFDFYAKRLAQQCQGFFSMVQHKDRFNLLKEILYLKRTFSGKHFDQVFVANINDLQIQFLLSAIDFNLLNTFDDGTINIVPNSLFYQDDPATLQRKLINVLLGNKYSIQSLRALSHTHYTIYKGFKNIIERVEPIELVAADNSEKVTSAVINVLLGQPVFAEDERNIALAERVIKQFNIHYYLPHPREKYRLAQVNYIDTELIFEDYILQQCQTHKYCVYTYFSSAIINIMNKSDNIEVVALKIDTENPAYDACYDLFDELGVNVIDIRE
UniProt ID: Q9CNN9
Variant: A -> T at position 167-167
Variant annotation: in strain: Serotype 10
Protein function: Structural rigidity of the outer membrane of elementary bodies and porin forming, permitting diffusion of solutes through the intracellular reticulate body membrane.
Reference sequence:
MKKTIVALAVAAVAATSANAATVYNQDGTKVDVNGSVRLLLKKEKDKRGDLMDNGSRVSFKASHDLGEGLSALAYAELRFSKDVKNKDGEVIKQPIGNNVHAKRLYAGFAYEGVGTLTFGNQLTIGDDVGVSDYTYFLGGINNLLSSGEKAINFKSAEFNGLTFGGAYVFSDDFDKNGLRDGRGFVVAGLYNRKIGDVGFAFEAGYSQKYVKQEVASVLPPPPGSVTVYKDEKEKAFMVGAELSYAGLALGVDYAQSKVTNVDGKKRALEVGLNYDINDKAKVYTDFIWAKEGPKGATTRDRSIILGAGYKLHKQVETFVEGGWGREKDANGVTTKDNVVGVGLRVHF
UniProt ID: Q9CNN9
Variant: PPP -> APS at position 221-223
Variant annotation: in strain: Serotype 10 and Serotype 12
Protein function: Structural rigidity of the outer membrane of elementary bodies and porin forming, permitting diffusion of solutes through the intracellular reticulate body membrane.
Reference sequence:
MKKTIVALAVAAVAATSANAATVYNQDGTKVDVNGSVRLLLKKEKDKRGDLMDNGSRVSFKASHDLGEGLSALAYAELRFSKDVKNKDGEVIKQPIGNNVHAKRLYAGFAYEGVGTLTFGNQLTIGDDVGVSDYTYFLGGINNLLSSGEKAINFKSAEFNGLTFGGAYVFSDDFDKNGLRDGRGFVVAGLYNRKIGDVGFAFEAGYSQKYVKQEVASVLPPPPGSVTVYKDEKEKAFMVGAELSYAGLALGVDYAQSKVTNVDGKKRALEVGLNYDINDKAKVYTDFIWAKEGPKGATTRDRSIILGAGYKLHKQVETFVEGGWGREKDANGVTTKDNVVGVGLRVHF
UniProt ID: Q9CPV0
Variant: E -> G at position 125-125
Variant annotation: in Schlei; decreases cilium assembly; loss of protein localization to cilium
Effect: loss
Protein function: Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types. During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins .
Reference sequence:
MGRISGLVPSRFLTLLAHLVVVITLFWSRESNIQACLPLKFTPEEYEKQDNQLVAALCLTLGLFAVELAGFLSGVSMFNSTQSLLSIAAHCSASVALSFFVFERWECTTYWYIFTFCSAFPAVTETALFIAVFGLKKKPF
UniProt ID: Q9CWP6
Variant: P -> S at position 288-288
Variant annotation: in strain: FVB/N
Protein function: Endoplasmic reticulum-anchored receptor which modulates interorganelle contacts by interacting with other organelle-bound proteins via their FFAT motif. Might have a more important role in endoplasmic reticulum and endosomes contacts. Promotes migration of primary monocytes and neutrophils, in response to various chemokines.
Reference sequence:
MAENNAQNKAKLISETRRRFEAEYVTEKSEKYDSRDVERLQQDDNWVESYLYWRHNVVDETLKMLDESFQWRKEFSVNDLSESSIPRWLLELGGIYLHGYDKEGNKLFWIRVKYHIKDQKTIMDKKKLIAFWLERYAKRENGKPITVMFDMSETGLNSIDMDFVRFIINCFKVYYPKYLSKIVIFDMPWIMNAAFKIVKSWLGPEAVSLLKFTSKNEIQEYVSVEYLPPHMGGTDPFKYSYPPLVDDDFQTPLCENGPIASEDETSSKEDIEGDGKETLETISNEEPPALSEKSNPTESVSKKDENEKVDSKTKTFKKPLSVFKGPLLHISPAEELYFGSIESGEKKTLIVLTNVTKNIVAFKVRTTAPEKYRVKPSNSSCDPGASIDIIVSPHGGLTVSAQDRFLIMAAEMEQSSGTGPAELSQFWKEVPRNKVMEHRLRCHTVESSKPNSLMLKDSISTMSDKTSEDLYLQLNRLLESNRKLEDQLQRSIWFQQLLLALTMVLLDFVVSFFYSLYN
UniProt ID: Q9D2N9
Variant: D -> E at position 251-251
Variant annotation: detected in mice with the buff mutation; leads to melanocytes with a reduced number of undermelanized melanosomes
Protein function: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39. The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG.
Reference sequence:
MAAHLSYGRVNLNVLREAVRRELREFLDKCAGSKAIVWDEYLTGPFGLIAQYSLLKEHEVEKMFTLKGSRLPAADVKNIIFLVRPRLELMDIIAENVLSEDRRGPTRDFHILFVPRRSLLCEQRLKDLGVLGSFIHREEYSLDLIPFDGDLLSMESEGAFKECYLEGDQTSLYHAAKGLMTLQALYGTIPQIFGKGECARQVANMMVRMKREFTGSQNSVFPVFDNLLLLDRNVDLLTPLASQLTYEGLIDEIYGIQNSYVKLPPEKFAPKKQGGGSGGKDLPTEAKKLQLNSAEELYAEIRDKNFNAVGSVLSKKAKIISAAFEERHNAKTVGEIKQFVSQLPHMQAARGSLANHTSIAELIKDVTTSEDFFDKLTVEQEFMSGIDTDKVNSYIEDCIAQKHPLIKVLRLVCLQSVCNSGLKQKVLDYYRREILQTYGYEHILTLNNLEKAGLLKAQTGGRNNYPTIRKTLRLWMDDVNEQNPTDISYVYSGYAPLSVRLAQLLSRPGWRSIEEVLRILPGPHFEERQPLPTGLQKKRQPGENRVTLVFFLGGVTFAEIAALRFLSQLEDGGTEYVIATTKLMNGNSWIEALMEKPF
UniProt ID: Q9D358
Variant: L -> P at position 14-14
Protein function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2.
Reference sequence:
MAEVGSKSVLFVCLGNICRSPIAEAVFRKLVTDEKVSDNWRIDSAATSTYEVGNPPDYRGQNCMRKHGIHMQHIARQITKEDFATFDYILCMDESNLRDLNRKSNQVKNCKAKIELLGSYDPQKQLIIEDPYYGNDSDFEVVYQQCLRCCKAFLEKTY
UniProt ID: Q9D358
Variant: T -> P at position 157-157
Protein function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2.
Reference sequence:
MAEVGSKSVLFVCLGNICRSPIAEAVFRKLVTDEKVSDNWRIDSAATSTYEVGNPPDYRGQNCMRKHGIHMQHIARQITKEDFATFDYILCMDESNLRDLNRKSNQVKNCKAKIELLGSYDPQKQLIIEDPYYGNDSDFEVVYQQCLRCCKAFLEKTY
UniProt ID: Q9D358
Variant: R -> H at position 67-67
Protein function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates with differences in substrate specificity between isoform 1 and isoform 2.
Reference sequence:
MAEVGSKSVLFVCLGNICRSPIAEAVFRKLVTDEKVSDNWRIDSAATSTYEVGNPPDYRGQNCMRKHGIHMQHIARQITKEDFATFDYILCMDESNLRDLNRKSNQVKNCKAKIELLGSYDPQKQLIIEDPYYGNDSDFEVVYQQCLRCCKAFLEKTY
UniProt ID: Q9DD06
Variant: C -> F at position 3-3
Variant annotation: in strain: FVB/N
Protein function: Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Acts also as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2. Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Exhibits an antimicrobial function in the skin.
Reference sequence:
MKCLLISLALWLGTVGTRGTEPELSETQRRSLQVALEEFHKHPPVQLAFQEIGVDRAEEVLFSAGTFVRLEFKLQQTNCPKKDWKKPECTIKPNGRRRKCLACIKMDPKGKILGRIVHCPILKQGPQDPQELQCIKIAQAGEDPHGYFLPGQFAFSRALRTK
UniProt ID: Q9EPI2
Variant: W -> R at position 257-257
Variant annotation: in 50% of the molecules
Protein function: Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.
Reference sequence:
MLSGAYLRVLNERPGQAVLWSLGCQRGSASSTEGNRCVEAAEACTADEQCQQLRSEYVAQCLGRAGWRGPGSCVRSRCRRALRRFFARGPPALTHALLFCGCEGPACAERRRQTFAPACAFSGPQLAPPSCLKPLDRCERSRRCRPRLFAFQASCAPAPGSRDGCPEEGGPRCLRAYAGLVGTVVTPNYLDNVSARVAPWCGCEASGNRREECEAFRKLFTRNPCLDGAIQAFDSSQPSVLQDQWNPYQNAGCCFLWVSSMSILTALALQALL
UniProt ID: Q9EQR3
Variant: E -> EE at position 66-66
Variant annotation: in strain: C57BL/6J, A/HeJ and SPRET/Ei
Protein function: Forms a voltage-independent potassium channel activated by intracellular calcium . Activation is followed by membrane hyperpolarization . Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization .
Reference sequence:
MSSHSHNGSVGQPLGSGPGFLGWEPVDPEAGRPLQPTQGPGLQMVAKGQPVRLSPGGSRGHPQEQEEEEEEEEEEDKTGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWERVSLISLELVVCAIHPVPGHYRFTWTARLAFSLVPSAAEADLDVLLSIPMFLRLYLLARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSVSSWIVAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQGRVRKHQRKFLQAIHQAQKLRSVKIEQGKVNDQANTLAELAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPGLIAQAICPLPPPWPGPGHLATATHSPQSHWLPTMGSDCG
UniProt ID: Q9EQR3
Variant: E -> EEE at position 66-66
Variant annotation: in strain: SWR/J, AKR/J, RBF/DNJ and P/J
Protein function: Forms a voltage-independent potassium channel activated by intracellular calcium . Activation is followed by membrane hyperpolarization . Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization .
Reference sequence:
MSSHSHNGSVGQPLGSGPGFLGWEPVDPEAGRPLQPTQGPGLQMVAKGQPVRLSPGGSRGHPQEQEEEEEEEEEEDKTGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWERVSLISLELVVCAIHPVPGHYRFTWTARLAFSLVPSAAEADLDVLLSIPMFLRLYLLARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSVSSWIVAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQGRVRKHQRKFLQAIHQAQKLRSVKIEQGKVNDQANTLAELAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPGLIAQAICPLPPPWPGPGHLATATHSPQSHWLPTMGSDCG
UniProt ID: Q9EQR3
Variant: H -> Q at position 522-522
Variant annotation: in strain: C57BL/6J
Protein function: Forms a voltage-independent potassium channel activated by intracellular calcium . Activation is followed by membrane hyperpolarization . Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization .
Reference sequence:
MSSHSHNGSVGQPLGSGPGFLGWEPVDPEAGRPLQPTQGPGLQMVAKGQPVRLSPGGSRGHPQEQEEEEEEEEEEDKTGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWERVSLISLELVVCAIHPVPGHYRFTWTARLAFSLVPSAAEADLDVLLSIPMFLRLYLLARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSVSSWIVAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQGRVRKHQRKFLQAIHQAQKLRSVKIEQGKVNDQANTLAELAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPGLIAQAICPLPPPWPGPGHLATATHSPQSHWLPTMGSDCG
UniProt ID: Q9EUE4
Variant: D -> G at position 15-15
Variant annotation: in strain: E32511
Protein function: Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation.
Reference sequence:
MNWIVIDTVIQPACDISFSAIWCNIKLILWYQSDIFLPPGCIFTPTRTGVILNNKELPVTIYNVTPFNKNVWNLIKSSQECPANTGNITDKCFNHRCILEICPYGRK
UniProt ID: Q9EUE4
Variant: I -> T at position 35-35
Variant annotation: in strain: E32511
Protein function: Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation.
Reference sequence:
MNWIVIDTVIQPACDISFSAIWCNIKLILWYQSDIFLPPGCIFTPTRTGVILNNKELPVTIYNVTPFNKNVWNLIKSSQECPANTGNITDKCFNHRCILEICPYGRK
UniProt ID: Q9EUE4
Variant: T -> A at position 65-65
Variant annotation: in strain: E32511
Protein function: Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation.
Reference sequence:
MNWIVIDTVIQPACDISFSAIWCNIKLILWYQSDIFLPPGCIFTPTRTGVILNNKELPVTIYNVTPFNKNVWNLIKSSQECPANTGNITDKCFNHRCILEICPYGRK
UniProt ID: Q9EUE4
Variant: S -> N at position 77-77
Variant annotation: in strain: E32511
Protein function: Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation.
Reference sequence:
MNWIVIDTVIQPACDISFSAIWCNIKLILWYQSDIFLPPGCIFTPTRTGVILNNKELPVTIYNVTPFNKNVWNLIKSSQECPANTGNITDKCFNHRCILEICPYGRK
UniProt ID: Q9EVG8
Variant: GE -> RG at position 22-23
Variant annotation: in strain: GA2181
Protein function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Reference sequence:
MTSKTLYQKIYDSHVVYEDKNGESILYIDLHLLHEVTSPQAFDALRSKKRKVRQSKKTFATMDHNVSTKIQSISASGSMAKKQMEQLIKNCRDFNIPLYDINNPNQGIVHVIAPEKGMTLPGMTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLKQKRFKNMKVEIIGKIPKFVTAKDIILFIIGQLGSSSGTGYVIEFCGDVIKNISMEERMTICNMAIEMGAKSGLIAPDEITYKYLKDKIYSPSGLFWEKSLDYWKFLKSDKNAHFDKCITLDISNLAPQITWGTNPDQVISIDEKIPDYNNINSLLKKESAKSACEYMGLKSNTYLTNISIDRVFIGSCTNARIEDLRAASKILKNRKIAKHVKAIVVPGSGSVKRKAEQEGLDKIFIDSGFEWRLPGCSMCLGMNKDRLNFGERCASTSNRNFEGRQGRGGRTH
UniProt ID: Q9EVG8
Variant: S -> N at position 47-47
Variant annotation: in strain: MNb027
Protein function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Reference sequence:
MTSKTLYQKIYDSHVVYEDKNGESILYIDLHLLHEVTSPQAFDALRSKKRKVRQSKKTFATMDHNVSTKIQSISASGSMAKKQMEQLIKNCRDFNIPLYDINNPNQGIVHVIAPEKGMTLPGMTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLKQKRFKNMKVEIIGKIPKFVTAKDIILFIIGQLGSSSGTGYVIEFCGDVIKNISMEERMTICNMAIEMGAKSGLIAPDEITYKYLKDKIYSPSGLFWEKSLDYWKFLKSDKNAHFDKCITLDISNLAPQITWGTNPDQVISIDEKIPDYNNINSLLKKESAKSACEYMGLKSNTYLTNISIDRVFIGSCTNARIEDLRAASKILKNRKIAKHVKAIVVPGSGSVKRKAEQEGLDKIFIDSGFEWRLPGCSMCLGMNKDRLNFGERCASTSNRNFEGRQGRGGRTH
UniProt ID: Q9EVG8
Variant: L -> F at position 254-254
Variant annotation: in strain: UT.002
Protein function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Reference sequence:
MTSKTLYQKIYDSHVVYEDKNGESILYIDLHLLHEVTSPQAFDALRSKKRKVRQSKKTFATMDHNVSTKIQSISASGSMAKKQMEQLIKNCRDFNIPLYDINNPNQGIVHVIAPEKGMTLPGMTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLKQKRFKNMKVEIIGKIPKFVTAKDIILFIIGQLGSSSGTGYVIEFCGDVIKNISMEERMTICNMAIEMGAKSGLIAPDEITYKYLKDKIYSPSGLFWEKSLDYWKFLKSDKNAHFDKCITLDISNLAPQITWGTNPDQVISIDEKIPDYNNINSLLKKESAKSACEYMGLKSNTYLTNISIDRVFIGSCTNARIEDLRAASKILKNRKIAKHVKAIVVPGSGSVKRKAEQEGLDKIFIDSGFEWRLPGCSMCLGMNKDRLNFGERCASTSNRNFEGRQGRGGRTH
UniProt ID: Q9EVG8
Variant: N -> K at position 312-312
Variant annotation: in strain: OH.036
Protein function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Reference sequence:
MTSKTLYQKIYDSHVVYEDKNGESILYIDLHLLHEVTSPQAFDALRSKKRKVRQSKKTFATMDHNVSTKIQSISASGSMAKKQMEQLIKNCRDFNIPLYDINNPNQGIVHVIAPEKGMTLPGMTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLKQKRFKNMKVEIIGKIPKFVTAKDIILFIIGQLGSSSGTGYVIEFCGDVIKNISMEERMTICNMAIEMGAKSGLIAPDEITYKYLKDKIYSPSGLFWEKSLDYWKFLKSDKNAHFDKCITLDISNLAPQITWGTNPDQVISIDEKIPDYNNINSLLKKESAKSACEYMGLKSNTYLTNISIDRVFIGSCTNARIEDLRAASKILKNRKIAKHVKAIVVPGSGSVKRKAEQEGLDKIFIDSGFEWRLPGCSMCLGMNKDRLNFGERCASTSNRNFEGRQGRGGRTH
UniProt ID: Q9EVG8
Variant: L -> V at position 315-315
Variant annotation: in strain: GA2181, MNb027, OH.036 and UT.002
Protein function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Reference sequence:
MTSKTLYQKIYDSHVVYEDKNGESILYIDLHLLHEVTSPQAFDALRSKKRKVRQSKKTFATMDHNVSTKIQSISASGSMAKKQMEQLIKNCRDFNIPLYDINNPNQGIVHVIAPEKGMTLPGMTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLKQKRFKNMKVEIIGKIPKFVTAKDIILFIIGQLGSSSGTGYVIEFCGDVIKNISMEERMTICNMAIEMGAKSGLIAPDEITYKYLKDKIYSPSGLFWEKSLDYWKFLKSDKNAHFDKCITLDISNLAPQITWGTNPDQVISIDEKIPDYNNINSLLKKESAKSACEYMGLKSNTYLTNISIDRVFIGSCTNARIEDLRAASKILKNRKIAKHVKAIVVPGSGSVKRKAEQEGLDKIFIDSGFEWRLPGCSMCLGMNKDRLNFGERCASTSNRNFEGRQGRGGRTH
UniProt ID: Q9EVG8
Variant: S -> A at position 339-339
Variant annotation: in strain: UT.002
Protein function: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Reference sequence:
MTSKTLYQKIYDSHVVYEDKNGESILYIDLHLLHEVTSPQAFDALRSKKRKVRQSKKTFATMDHNVSTKIQSISASGSMAKKQMEQLIKNCRDFNIPLYDINNPNQGIVHVIAPEKGMTLPGMTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLKQKRFKNMKVEIIGKIPKFVTAKDIILFIIGQLGSSSGTGYVIEFCGDVIKNISMEERMTICNMAIEMGAKSGLIAPDEITYKYLKDKIYSPSGLFWEKSLDYWKFLKSDKNAHFDKCITLDISNLAPQITWGTNPDQVISIDEKIPDYNNINSLLKKESAKSACEYMGLKSNTYLTNISIDRVFIGSCTNARIEDLRAASKILKNRKIAKHVKAIVVPGSGSVKRKAEQEGLDKIFIDSGFEWRLPGCSMCLGMNKDRLNFGERCASTSNRNFEGRQGRGGRTH
UniProt ID: Q9EYW9
Variant: A -> P at position 92-92
Variant annotation: in strain: LO28
Protein function: Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid.
Reference sequence:
MLYSKENKESYLEPVFGSSAEDRDIPKYTLGKEPLEPRIAYRLVKDELLDEGSARQNLATFCQTYMEDEATKLMSETLEKNAIDKSEYPRTAELENRCVNIIADLWHAPKDQKFMGTSTIGSSEACMLGGMAMKFAWRKRAEKLGLDIYAKKPNLVISSGYQVCWEKFCVYWDIDMRVVPMDKEHMQLNTDQVLDYVDEYTIGVVGILGITYTGRYDDIYALNEKLEEYNSKTDYKVYIHVDAASGGFFTPFVEPDIIWDFRLKNVISINTSGHKYGLVYPGIGWVLWKDESYLPEELIFKVSYLGGEMPTMQINFSRSASHIIGQYYNFLRYGFEGYRTIHQKTSDVAQYLAHAVEQTGYFDIFNDGSHLPIVCYKLKDDANVNWTLYDLADRLQMRGWQVPAYPLPKSLENIIIQRYVCRADLGFNMAEEFIQDFQASIQELNNAHILFHDTQQSGVHGFTH
UniProt ID: Q9EYW9
Variant: E -> D at position 124-124
Variant annotation: in strain: LO28
Protein function: Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid.
Reference sequence:
MLYSKENKESYLEPVFGSSAEDRDIPKYTLGKEPLEPRIAYRLVKDELLDEGSARQNLATFCQTYMEDEATKLMSETLEKNAIDKSEYPRTAELENRCVNIIADLWHAPKDQKFMGTSTIGSSEACMLGGMAMKFAWRKRAEKLGLDIYAKKPNLVISSGYQVCWEKFCVYWDIDMRVVPMDKEHMQLNTDQVLDYVDEYTIGVVGILGITYTGRYDDIYALNEKLEEYNSKTDYKVYIHVDAASGGFFTPFVEPDIIWDFRLKNVISINTSGHKYGLVYPGIGWVLWKDESYLPEELIFKVSYLGGEMPTMQINFSRSASHIIGQYYNFLRYGFEGYRTIHQKTSDVAQYLAHAVEQTGYFDIFNDGSHLPIVCYKLKDDANVNWTLYDLADRLQMRGWQVPAYPLPKSLENIIIQRYVCRADLGFNMAEEFIQDFQASIQELNNAHILFHDTQQSGVHGFTH
UniProt ID: Q9EYW9
Variant: F -> L at position 261-261
Variant annotation: in strain: EGD5
Protein function: Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid.
Reference sequence:
MLYSKENKESYLEPVFGSSAEDRDIPKYTLGKEPLEPRIAYRLVKDELLDEGSARQNLATFCQTYMEDEATKLMSETLEKNAIDKSEYPRTAELENRCVNIIADLWHAPKDQKFMGTSTIGSSEACMLGGMAMKFAWRKRAEKLGLDIYAKKPNLVISSGYQVCWEKFCVYWDIDMRVVPMDKEHMQLNTDQVLDYVDEYTIGVVGILGITYTGRYDDIYALNEKLEEYNSKTDYKVYIHVDAASGGFFTPFVEPDIIWDFRLKNVISINTSGHKYGLVYPGIGWVLWKDESYLPEELIFKVSYLGGEMPTMQINFSRSASHIIGQYYNFLRYGFEGYRTIHQKTSDVAQYLAHAVEQTGYFDIFNDGSHLPIVCYKLKDDANVNWTLYDLADRLQMRGWQVPAYPLPKSLENIIIQRYVCRADLGFNMAEEFIQDFQASIQELNNAHILFHDTQQSGVHGFTH
UniProt ID: Q9EYW9
Variant: C -> R at position 375-375
Variant annotation: in strain: EGD5
Protein function: Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid.
Reference sequence:
MLYSKENKESYLEPVFGSSAEDRDIPKYTLGKEPLEPRIAYRLVKDELLDEGSARQNLATFCQTYMEDEATKLMSETLEKNAIDKSEYPRTAELENRCVNIIADLWHAPKDQKFMGTSTIGSSEACMLGGMAMKFAWRKRAEKLGLDIYAKKPNLVISSGYQVCWEKFCVYWDIDMRVVPMDKEHMQLNTDQVLDYVDEYTIGVVGILGITYTGRYDDIYALNEKLEEYNSKTDYKVYIHVDAASGGFFTPFVEPDIIWDFRLKNVISINTSGHKYGLVYPGIGWVLWKDESYLPEELIFKVSYLGGEMPTMQINFSRSASHIIGQYYNFLRYGFEGYRTIHQKTSDVAQYLAHAVEQTGYFDIFNDGSHLPIVCYKLKDDANVNWTLYDLADRLQMRGWQVPAYPLPKSLENIIIQRYVCRADLGFNMAEEFIQDFQASIQELNNAHILFHDTQQSGVHGFTH
UniProt ID: Q9EYW9
Variant: DD -> TT at position 380-381
Variant annotation: in strain: LO28
Protein function: Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance in gastric fluid.
Reference sequence:
MLYSKENKESYLEPVFGSSAEDRDIPKYTLGKEPLEPRIAYRLVKDELLDEGSARQNLATFCQTYMEDEATKLMSETLEKNAIDKSEYPRTAELENRCVNIIADLWHAPKDQKFMGTSTIGSSEACMLGGMAMKFAWRKRAEKLGLDIYAKKPNLVISSGYQVCWEKFCVYWDIDMRVVPMDKEHMQLNTDQVLDYVDEYTIGVVGILGITYTGRYDDIYALNEKLEEYNSKTDYKVYIHVDAASGGFFTPFVEPDIIWDFRLKNVISINTSGHKYGLVYPGIGWVLWKDESYLPEELIFKVSYLGGEMPTMQINFSRSASHIIGQYYNFLRYGFEGYRTIHQKTSDVAQYLAHAVEQTGYFDIFNDGSHLPIVCYKLKDDANVNWTLYDLADRLQMRGWQVPAYPLPKSLENIIIQRYVCRADLGFNMAEEFIQDFQASIQELNNAHILFHDTQQSGVHGFTH
UniProt ID: Q9FG67
Variant: V -> G at position 10-10
Variant annotation: in strain: cv. Sorbo
Protein function: Determines the side chain length of aliphatic glucosinolate structures. Catalyzes exclusively the condensation reactions of both the first and second methionine carbon chain elongation.
Reference sequence:
MASSLLTSSVMIPTTGSTVVGRSVLPFQSSLHSLRLTHSYKNPALFISCCSSVSKNAATSSTDLKPVVERWPEYIPNKLPDGNYVRVFDTTLRDGEQSPGGSLTPPQKLEIARQLAKLRVDIMEVGFPGSSEEELETIKTIAKTVGNEVDEETGYVPVICAIARCKHRDIEATWEALKYAKRPRILVFTSTSDIHMKYKLKKTQEEVIEMAVSSIRFAKSLGFNDIQFGCEDGGRSDKDFLCKILGEAIKAGVTVVTIGDTVGINMPHEYGELVTYLKANTPGIDDVVVAVHCHNDLGLATANSIAGIRAGARQVEVTINGIGERSGNASLEEVVMALKCRGAYVINGVYTKIDTRQIMATSKMVQEYTGLYVQAHKPIVGANCFVHESGIHQDGILKNRSTYEILSPEDIGIVKSQNSGLVLGKLSGRHAVKDRLKELGYELDDEKLNAVFSLFRDLTKNKKRITDADLKALVTSSDEISLEKLNGANGLKSNGYIPVPQVSSNV