sujigwak/NVAR huggingface dataset:
UniProt ID: Q9HD40
Variant: Y -> C at position 334-334
Variant annotation: in PCH2D; abrogates enzyme activity; dbSNP:rs267607036
Protein function: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
Reference sequence:
MNRESFAAGERLVSPAYVRQGCEARRSHEHLIRLLLEKGKCPENGWDESTLELFLHELAIMDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRSGDISAVQPKAAGSSLLNKITNSLVLDIIKLAGVHTVANCFVVPMATGMSLTLCFLTLRHKRPKAKYIIWPRIDQKSCFKSMITAGFEPVVIENVLEGDELRTDLKAVEAKVQELGPDCILCIHSTTSCFAPRVPDRLEELAVICANYDIPHIVNNAYGVQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVPVGGAIIAGFNDSFIQEISKMYPGRASASPSLDVLITLLSLGSNGYKKLLKERKEMFSYLSNQIKKLSEAYNERLLHTPHNPISLAMTLKTLDEHRDKAVTQLGSMLFTRQVSGARVVPLGSMQTVSGYTFRGFMSHTNNYPCAYLNAASAIGMKMQDVDLFIKRLDRCLKAVRKERSKESDDNYDKTEDVDIEEMALKLDNVLLDTYQDASS
UniProt ID: Q9HDC5
Variant: T -> M at position 507-507
Variant annotation: in dbSNP:rs16938829
Protein function: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Reference sequence:
MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHDAAAAADSPAGTRGGFVLNFHADAELAGKKKGGLFRRGSLLGSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGVSERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNILVRGIRKQLIPIRHTKTREKVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAADQAALAARQECDIARAVARELSPDFYQPGPDYVKQRFQEGVDAKENPEEKVPEKPPTPKESPHFYRKGTTPPRSPEASPKHSHSPASSPKPLKKQNPSSGARLNQDKRSVADEQVTAIVNKPLMSKAPTKEAGAVVPQSKYSGRHHIPNPSNGELHSQYHGYYVKLNAPQHPPVDVEDGDGSSQSSSALVHKPSANKWSPSKSVTKPVAKESKAEPKAKKSELAIPKNPASNDSCPALEKEANSGPNSIMIVLVMLLNIGLAILFVHFLT
UniProt ID: Q9HDC5
Variant: D -> H at position 624-624
Variant annotation: in dbSNP:rs16938828
Protein function: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Reference sequence:
MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHDAAAAADSPAGTRGGFVLNFHADAELAGKKKGGLFRRGSLLGSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGVSERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNILVRGIRKQLIPIRHTKTREKVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAADQAALAARQECDIARAVARELSPDFYQPGPDYVKQRFQEGVDAKENPEEKVPEKPPTPKESPHFYRKGTTPPRSPEASPKHSHSPASSPKPLKKQNPSSGARLNQDKRSVADEQVTAIVNKPLMSKAPTKEAGAVVPQSKYSGRHHIPNPSNGELHSQYHGYYVKLNAPQHPPVDVEDGDGSSQSSSALVHKPSANKWSPSKSVTKPVAKESKAEPKAKKSELAIPKNPASNDSCPALEKEANSGPNSIMIVLVMLLNIGLAILFVHFLT
UniProt ID: Q9HTC0
Variant: A -> T at position 259-259
Variant annotation: in clinical isolates: GKK-1 and GKK-3; colistin-resistant
Protein function: Non-processive alpha-1,3-D-rhamnosyltransferase . Catalyzes the transfer of one D-rhamnose (D-Rha) residue from donor substrate GDP-D-Rha in alpha-1-3 linkage to both GlcNAc- and GalNAc-diphosphate-lipid acceptor substrates. Is also able to transfer D-mannose (D-Man) to these acceptors at a lower level. Nucleotide sugars GDP-D-Rha, GDP-Fuc, UDP-Gal, UDP-GalNAc, UDP-GlcNAc and CMP-sialic acid cannot act as donor substrates. Only compounds with a diphosphate as the aglycone group can act as acceptor substrates. No activity is detected with compounds containing a diphosphate mimic. Fluorescent undecyl-anthracenyl group-containing compounds, such as GlcNAc-PO(3)-PO(3)-AnthrU and GalNAc-PO(3)-PO(3)-AnthrU, are also good acceptor substrates . Involved in the biosynthesis of the common polysaccharide antigen (CPA), also called A band, which is one of the two major cell surface O-antigens of the P.aeruginosa lipopolysaccharide . Involved in susceptibility to antibiotic colistin .
Reference sequence:
MRVLHFYKTYLSETVGGIEQVIFQLCESSGSWGIDNHVLTLSSDPHPPVVPFGGHVVHRARLDLQLASTGFSLSVFKQFRELAAEADVVNYHFPWPFMDLVHFLTGMNKPSVVTYHSDIIRQRVLLKLYRPLMSRFLHSVDRIVAASPNYFSTSDVLRQYREKTRVITYGLDKDGYPKPATQRLEHWREKLGPRFFLFVGVMRYYKGLHILLDALQGTDYPVVIVGAGPLQAELYAQAAALGLRNVHFLGRVDDEDKVALLQLSYAMVFPSHLRSEAFGISLLEGAMYGKPMISSEIGTGTSYINIHGETGLVVPPSQPAAFRQAMRWLWEHPQQAEEMGRNAEARYRQLFTAEEMGRRWSELYRELLEEKASSRYVKAAR
UniProt ID: Q9I317
Variant: C -> G at position 40-40
Variant annotation: in strain: 388
Protein function: Chaperone of the type III secretion (T3S) injectisome that translocates effector toxins into host cells, facilitating the establishment and dissemination of infection. Prevents premature polymerization of PscF, along with PscG, within the cytoplasm . Required for type III secretion needle assembly. Also required for cytotoxicity by influencing PscF levels.
Reference sequence:
MMTALETRLSVADGTHAAALRQRLQAALAECRRELARGACPEHFQFLQQQARALEGGLGILSQLTED
UniProt ID: Q9I317
Variant: H -> R at position 43-43
Variant annotation: in strain: 388
Protein function: Chaperone of the type III secretion (T3S) injectisome that translocates effector toxins into host cells, facilitating the establishment and dissemination of infection. Prevents premature polymerization of PscF, along with PscG, within the cytoplasm . Required for type III secretion needle assembly. Also required for cytotoxicity by influencing PscF levels.
Reference sequence:
MMTALETRLSVADGTHAAALRQRLQAALAECRRELARGACPEHFQFLQQQARALEGGLGILSQLTED
UniProt ID: Q9I8X1
Variant: D -> N at position 70-70
Variant annotation: in AaV-SP-II
Protein function: Snake venom serine protease that has fibrinogenolytic activities. Also possess esterolysis and amidolytic activities. Selectively cleaves Arg-|-Xaa bonds.
Reference sequence:
MVLIRVLANLLILQLSYAQKSSELVIGGNECDINEHRFLVAFFNTTGFFCGGTLINPEWVVTAAHCDSTDFQMQLGVHSKKVLNEDEQTRNPKEKFICPNKNNNEVLDKDIMLIKLDKPISNSKHIAPLSLPSSPPSVGSVCRIMGWGSITPVKETFPDVPYCANINLLDHAVCQAGYPELLAEYRTLCAGIVQGGKDTCGGDSGGPLICNGQFQGIVSYGAHPCGQGPKPGIYTNVFDYTDWIQRNIAGNTDATCPP
UniProt ID: Q9JHW6
Variant: L -> F at position 156-156
Variant annotation: in N(1),N(12)-bis(ethyl)spermine-resistant cell line C55.7Res
Protein function: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Also acts on 1,3-diaminopropane and 1,5-diaminopentane.
Reference sequence:
MAKFKIRPATASDCSDILRLIKELAKYEYMEDQVMLTEKDLLEDGFGEHPFYHCLIAEVPKEHWTPEGHSIVGFAMYYFTYDPWIGKLLYLEDFFVMSDYRGFGIGSEILKNLSQVAMKCRCSSMHFLVAEWNEPSINFYKRRGASDLSSEEGWRLFKIDKEYLLKMAAEE
UniProt ID: Q9JKT4
Variant: T -> I at position 44-44
Variant annotation: in strain: BALB/c, C3H/He, CBA/Ca and DBA/2J
Protein function: Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Reference sequence:
MLSAAEGILLSIATVEAGLGVLGNTFIALVNCMDWAKNNKLSMTGFLLIGLATSRIFIVWLLTLDAYAKLFYPSKYFSSSLIEIISYIWMTVNHLTVWFATSLSIFYFLKIANFSDCVFLWLKRRTDKAFVFLLGCLLTSWVISFSFVVKVMKDGKVNHRNRTSEMYWEKRQFTINYVFLNIGVISLFMMTLTACFLLIMSLWRHSRQMQSGVSGFRDLNTEAHVKAIKFLISFIILFVLYFIGVSIEIICIFIPENKLLFIFGFTTASIYPCCHSFILILSNSQLKQAFVKVLQGLKFF
UniProt ID: Q9JKT4
Variant: G -> D at position 155-155
Variant annotation: in strain: BALB/c, C3H/He, CBA/Ca and DBA/2J
Protein function: Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Reference sequence:
MLSAAEGILLSIATVEAGLGVLGNTFIALVNCMDWAKNNKLSMTGFLLIGLATSRIFIVWLLTLDAYAKLFYPSKYFSSSLIEIISYIWMTVNHLTVWFATSLSIFYFLKIANFSDCVFLWLKRRTDKAFVFLLGCLLTSWVISFSFVVKVMKDGKVNHRNRTSEMYWEKRQFTINYVFLNIGVISLFMMTLTACFLLIMSLWRHSRQMQSGVSGFRDLNTEAHVKAIKFLISFIILFVLYFIGVSIEIICIFIPENKLLFIFGFTTASIYPCCHSFILILSNSQLKQAFVKVLQGLKFF
UniProt ID: Q9JKT4
Variant: L -> R at position 294-294
Variant annotation: in strain: BALB/c, C3H/He, CBA/Ca and DBA/2J
Protein function: Gustducin-coupled cycloheximide receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
Reference sequence:
MLSAAEGILLSIATVEAGLGVLGNTFIALVNCMDWAKNNKLSMTGFLLIGLATSRIFIVWLLTLDAYAKLFYPSKYFSSSLIEIISYIWMTVNHLTVWFATSLSIFYFLKIANFSDCVFLWLKRRTDKAFVFLLGCLLTSWVISFSFVVKVMKDGKVNHRNRTSEMYWEKRQFTINYVFLNIGVISLFMMTLTACFLLIMSLWRHSRQMQSGVSGFRDLNTEAHVKAIKFLISFIILFVLYFIGVSIEIICIFIPENKLLFIFGFTTASIYPCCHSFILILSNSQLKQAFVKVLQGLKFF
UniProt ID: Q9JT70
Variant: VGC -> ARH at position 2-4
Variant annotation: in strain: 1014 and 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: L -> F at position 31-31
Variant annotation: in strain: 1014 and 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: P -> L at position 68-68
Variant annotation: in strain: 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: P -> S at position 75-75
Variant annotation: in strain: 1014
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: S -> P at position 84-84
Variant annotation: in strain: 1014 and 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: A -> E at position 87-87
Variant annotation: in strain: 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: A -> V at position 87-87
Variant annotation: in strain: 1014
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: H -> R at position 102-102
Variant annotation: in strain: 1014 and 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: V -> I at position 105-105
Variant annotation: in strain: 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: I -> V at position 115-115
Variant annotation: in strain: 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: T -> N at position 125-125
Variant annotation: in strain: 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: L -> V at position 130-130
Variant annotation: in strain: 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: C -> R at position 135-135
Variant annotation: in strain: 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: Q -> R at position 147-147
Variant annotation: in strain: 1014
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: K -> E at position 151-151
Variant annotation: in strain: 1014
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: N -> T at position 152-152
Variant annotation: in strain: 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: A -> S at position 174-174
Variant annotation: in strain: 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: T -> I at position 188-188
Variant annotation: in strain: 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: C -> G at position 194-194
Variant annotation: in strain: 1014
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: C -> GSG at position 194-194
Variant annotation: in strain: 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: T -> P at position 198-198
Variant annotation: in strain: 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: T -> A at position 204-204
Variant annotation: in strain: 1014 and 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: Y -> F at position 218-218
Variant annotation: in strain: 1014 and 418
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL
UniProt ID: Q9JT70
Variant: S -> R at position 228-228
Variant annotation: in strain: 1014
Protein function: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Reference sequence:
MVGCVWQAGRFEIGLDKPKIMGIVNLTPDSLSDGGAYSQNAQTALAHAERLLKEGADILDIGGESTRPGADYVSPEEEWARVESVLAEVAGWGVPVSLDTRHTVVMEKALALGGIDIINDVAALTDEGALELLACQADTGICLMHMQGLPKNMQINPKYQDVVGEVARYLKARAAECIAAGIAPQRITLDPGFCFGKTLQHNITLMRHLPELMAETGYPLLIGVSRKSMIGELTGETDAAARGHGSVAAALAAVARGAKIVRVHDVKATADALKAWEALGINL