sujigwak/NVAR huggingface dataset:
UniProt ID: O24617
Variant: T -> A at position 404-404
Variant annotation: in strain: cv. Landsberg erecta
Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Forms three different heterodimers: MutS alpha (MSH2-MSH6 heterodimer), MutS beta (MSH2-MSH3 heterodimer) and MutS gamma (MSH2-MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha and MutS beta recognize single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. MutS gamma recognizes specifically the T/G single base mismatch. Plays a role in DNA homologous recombination repair and has a broad range of anti-recombination effects. Can suppress recombination between divergent direct repeats in somatic cells and possesses an anti-recombination meiotic effect. Is involved in a UV-B-induced DNA damage response pathway.
Reference sequence:
MEGNFEEQNKLPELKLDAKQAQGFLSFYKTLPNDTRAVRFFDRKDYYTAHGENSVFIAKTYYHTTTALRQLGSGSNALSSVSISRNMFETIARDLLLERNDHTVELYEGSGSNWRLVKTGSPGNIGSFEDVLFANNEMQDTPVVVSIFPSFHDGRCVIGMAYVDLTRRVLGLAEFLDDSRFTNLESSLIALGAKECIFPAESGKSNECKSLYDSLERCAVMITERKKHEFKGRDLDSDLKRLVKGNIEPVRDLVSGFDLATPALGALLSFSELLSNEDNYGNFTIRRYDIGGFMRLDSAAMRALNVMESKTDANKNFSLFGLMNRTCTAGMGKRLLHMWLKQPLVDLNEIKTRLDIVQCFVEEAGLRQDLRQHLKRISDVERLLRSLERRRGGLQHIIKLYQSTIRLPFIKTAMQQYTGEFASLISERYLKKLEALSDQDHLGKFIDLVECSVDLDQLENGEYMISSSYDTKLASLKDQKELLEQQIHELHKKTAIELDLQVDKALKLDKAAQFGHVFRITKKEEPKIRKKLTTQFIVLETRKDGVKFTNTKLKKLGDQYQSVVDDYRSCQKELVDRVVETVTSFSEVFEDLAGLLSEMDVLLSFADLAASCPTPYCRPEITSSDAGDIVLEGSRHPCVEAQDWVNFIPNDCRLMRGKSWFQIVTGPNMGGKSTFIRQVGVIVLMAQVGSFVPCDKASISIRDCIFARVGAGDCQLRGVSTFMQEMLETASILKGASDKSLIIIDELGRGTSTYDGFGLAWAICEHLVQVKRAPTLFATHFHELTALAQANSEVSGNTVGVANFHVSAHIDTESRKLTMLYKVEPGACDQSFGIHVAEFANFPESVVALAREKAAELEDFSPSSMIINNEESGKRKSREDDPDEVSRGAERAHKFLKEFAAIPLDKMELKDSLQRVREMKDELEKDAADCHWLRQFL
UniProt ID: O24617
Variant: S -> N at position 468-468
Variant annotation: in strain: cv. Landsberg erecta
Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Forms three different heterodimers: MutS alpha (MSH2-MSH6 heterodimer), MutS beta (MSH2-MSH3 heterodimer) and MutS gamma (MSH2-MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha and MutS beta recognize single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. MutS gamma recognizes specifically the T/G single base mismatch. Plays a role in DNA homologous recombination repair and has a broad range of anti-recombination effects. Can suppress recombination between divergent direct repeats in somatic cells and possesses an anti-recombination meiotic effect. Is involved in a UV-B-induced DNA damage response pathway.
Reference sequence:
MEGNFEEQNKLPELKLDAKQAQGFLSFYKTLPNDTRAVRFFDRKDYYTAHGENSVFIAKTYYHTTTALRQLGSGSNALSSVSISRNMFETIARDLLLERNDHTVELYEGSGSNWRLVKTGSPGNIGSFEDVLFANNEMQDTPVVVSIFPSFHDGRCVIGMAYVDLTRRVLGLAEFLDDSRFTNLESSLIALGAKECIFPAESGKSNECKSLYDSLERCAVMITERKKHEFKGRDLDSDLKRLVKGNIEPVRDLVSGFDLATPALGALLSFSELLSNEDNYGNFTIRRYDIGGFMRLDSAAMRALNVMESKTDANKNFSLFGLMNRTCTAGMGKRLLHMWLKQPLVDLNEIKTRLDIVQCFVEEAGLRQDLRQHLKRISDVERLLRSLERRRGGLQHIIKLYQSTIRLPFIKTAMQQYTGEFASLISERYLKKLEALSDQDHLGKFIDLVECSVDLDQLENGEYMISSSYDTKLASLKDQKELLEQQIHELHKKTAIELDLQVDKALKLDKAAQFGHVFRITKKEEPKIRKKLTTQFIVLETRKDGVKFTNTKLKKLGDQYQSVVDDYRSCQKELVDRVVETVTSFSEVFEDLAGLLSEMDVLLSFADLAASCPTPYCRPEITSSDAGDIVLEGSRHPCVEAQDWVNFIPNDCRLMRGKSWFQIVTGPNMGGKSTFIRQVGVIVLMAQVGSFVPCDKASISIRDCIFARVGAGDCQLRGVSTFMQEMLETASILKGASDKSLIIIDELGRGTSTYDGFGLAWAICEHLVQVKRAPTLFATHFHELTALAQANSEVSGNTVGVANFHVSAHIDTESRKLTMLYKVEPGACDQSFGIHVAEFANFPESVVALAREKAAELEDFSPSSMIINNEESGKRKSREDDPDEVSRGAERAHKFLKEFAAIPLDKMELKDSLQRVREMKDELEKDAADCHWLRQFL
UniProt ID: O24617
Variant: S -> L at position 624-624
Variant annotation: in strain: cv. Landsberg erecta
Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Forms three different heterodimers: MutS alpha (MSH2-MSH6 heterodimer), MutS beta (MSH2-MSH3 heterodimer) and MutS gamma (MSH2-MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha and MutS beta recognize single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. MutS gamma recognizes specifically the T/G single base mismatch. Plays a role in DNA homologous recombination repair and has a broad range of anti-recombination effects. Can suppress recombination between divergent direct repeats in somatic cells and possesses an anti-recombination meiotic effect. Is involved in a UV-B-induced DNA damage response pathway.
Reference sequence:
MEGNFEEQNKLPELKLDAKQAQGFLSFYKTLPNDTRAVRFFDRKDYYTAHGENSVFIAKTYYHTTTALRQLGSGSNALSSVSISRNMFETIARDLLLERNDHTVELYEGSGSNWRLVKTGSPGNIGSFEDVLFANNEMQDTPVVVSIFPSFHDGRCVIGMAYVDLTRRVLGLAEFLDDSRFTNLESSLIALGAKECIFPAESGKSNECKSLYDSLERCAVMITERKKHEFKGRDLDSDLKRLVKGNIEPVRDLVSGFDLATPALGALLSFSELLSNEDNYGNFTIRRYDIGGFMRLDSAAMRALNVMESKTDANKNFSLFGLMNRTCTAGMGKRLLHMWLKQPLVDLNEIKTRLDIVQCFVEEAGLRQDLRQHLKRISDVERLLRSLERRRGGLQHIIKLYQSTIRLPFIKTAMQQYTGEFASLISERYLKKLEALSDQDHLGKFIDLVECSVDLDQLENGEYMISSSYDTKLASLKDQKELLEQQIHELHKKTAIELDLQVDKALKLDKAAQFGHVFRITKKEEPKIRKKLTTQFIVLETRKDGVKFTNTKLKKLGDQYQSVVDDYRSCQKELVDRVVETVTSFSEVFEDLAGLLSEMDVLLSFADLAASCPTPYCRPEITSSDAGDIVLEGSRHPCVEAQDWVNFIPNDCRLMRGKSWFQIVTGPNMGGKSTFIRQVGVIVLMAQVGSFVPCDKASISIRDCIFARVGAGDCQLRGVSTFMQEMLETASILKGASDKSLIIIDELGRGTSTYDGFGLAWAICEHLVQVKRAPTLFATHFHELTALAQANSEVSGNTVGVANFHVSAHIDTESRKLTMLYKVEPGACDQSFGIHVAEFANFPESVVALAREKAAELEDFSPSSMIINNEESGKRKSREDDPDEVSRGAERAHKFLKEFAAIPLDKMELKDSLQRVREMKDELEKDAADCHWLRQFL
UniProt ID: O24617
Variant: S -> T at position 737-737
Variant annotation: in strain: cv. Landsberg erecta
Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Forms three different heterodimers: MutS alpha (MSH2-MSH6 heterodimer), MutS beta (MSH2-MSH3 heterodimer) and MutS gamma (MSH2-MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha and MutS beta recognize single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. MutS gamma recognizes specifically the T/G single base mismatch. Plays a role in DNA homologous recombination repair and has a broad range of anti-recombination effects. Can suppress recombination between divergent direct repeats in somatic cells and possesses an anti-recombination meiotic effect. Is involved in a UV-B-induced DNA damage response pathway.
Reference sequence:
MEGNFEEQNKLPELKLDAKQAQGFLSFYKTLPNDTRAVRFFDRKDYYTAHGENSVFIAKTYYHTTTALRQLGSGSNALSSVSISRNMFETIARDLLLERNDHTVELYEGSGSNWRLVKTGSPGNIGSFEDVLFANNEMQDTPVVVSIFPSFHDGRCVIGMAYVDLTRRVLGLAEFLDDSRFTNLESSLIALGAKECIFPAESGKSNECKSLYDSLERCAVMITERKKHEFKGRDLDSDLKRLVKGNIEPVRDLVSGFDLATPALGALLSFSELLSNEDNYGNFTIRRYDIGGFMRLDSAAMRALNVMESKTDANKNFSLFGLMNRTCTAGMGKRLLHMWLKQPLVDLNEIKTRLDIVQCFVEEAGLRQDLRQHLKRISDVERLLRSLERRRGGLQHIIKLYQSTIRLPFIKTAMQQYTGEFASLISERYLKKLEALSDQDHLGKFIDLVECSVDLDQLENGEYMISSSYDTKLASLKDQKELLEQQIHELHKKTAIELDLQVDKALKLDKAAQFGHVFRITKKEEPKIRKKLTTQFIVLETRKDGVKFTNTKLKKLGDQYQSVVDDYRSCQKELVDRVVETVTSFSEVFEDLAGLLSEMDVLLSFADLAASCPTPYCRPEITSSDAGDIVLEGSRHPCVEAQDWVNFIPNDCRLMRGKSWFQIVTGPNMGGKSTFIRQVGVIVLMAQVGSFVPCDKASISIRDCIFARVGAGDCQLRGVSTFMQEMLETASILKGASDKSLIIIDELGRGTSTYDGFGLAWAICEHLVQVKRAPTLFATHFHELTALAQANSEVSGNTVGVANFHVSAHIDTESRKLTMLYKVEPGACDQSFGIHVAEFANFPESVVALAREKAAELEDFSPSSMIINNEESGKRKSREDDPDEVSRGAERAHKFLKEFAAIPLDKMELKDSLQRVREMKDELEKDAADCHWLRQFL
UniProt ID: O24617
Variant: I -> M at position 902-902
Variant annotation: in strain: cv. Landsberg erecta
Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Forms three different heterodimers: MutS alpha (MSH2-MSH6 heterodimer), MutS beta (MSH2-MSH3 heterodimer) and MutS gamma (MSH2-MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha and MutS beta recognize single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. MutS gamma recognizes specifically the T/G single base mismatch. Plays a role in DNA homologous recombination repair and has a broad range of anti-recombination effects. Can suppress recombination between divergent direct repeats in somatic cells and possesses an anti-recombination meiotic effect. Is involved in a UV-B-induced DNA damage response pathway.
Reference sequence:
MEGNFEEQNKLPELKLDAKQAQGFLSFYKTLPNDTRAVRFFDRKDYYTAHGENSVFIAKTYYHTTTALRQLGSGSNALSSVSISRNMFETIARDLLLERNDHTVELYEGSGSNWRLVKTGSPGNIGSFEDVLFANNEMQDTPVVVSIFPSFHDGRCVIGMAYVDLTRRVLGLAEFLDDSRFTNLESSLIALGAKECIFPAESGKSNECKSLYDSLERCAVMITERKKHEFKGRDLDSDLKRLVKGNIEPVRDLVSGFDLATPALGALLSFSELLSNEDNYGNFTIRRYDIGGFMRLDSAAMRALNVMESKTDANKNFSLFGLMNRTCTAGMGKRLLHMWLKQPLVDLNEIKTRLDIVQCFVEEAGLRQDLRQHLKRISDVERLLRSLERRRGGLQHIIKLYQSTIRLPFIKTAMQQYTGEFASLISERYLKKLEALSDQDHLGKFIDLVECSVDLDQLENGEYMISSSYDTKLASLKDQKELLEQQIHELHKKTAIELDLQVDKALKLDKAAQFGHVFRITKKEEPKIRKKLTTQFIVLETRKDGVKFTNTKLKKLGDQYQSVVDDYRSCQKELVDRVVETVTSFSEVFEDLAGLLSEMDVLLSFADLAASCPTPYCRPEITSSDAGDIVLEGSRHPCVEAQDWVNFIPNDCRLMRGKSWFQIVTGPNMGGKSTFIRQVGVIVLMAQVGSFVPCDKASISIRDCIFARVGAGDCQLRGVSTFMQEMLETASILKGASDKSLIIIDELGRGTSTYDGFGLAWAICEHLVQVKRAPTLFATHFHELTALAQANSEVSGNTVGVANFHVSAHIDTESRKLTMLYKVEPGACDQSFGIHVAEFANFPESVVALAREKAAELEDFSPSSMIINNEESGKRKSREDDPDEVSRGAERAHKFLKEFAAIPLDKMELKDSLQRVREMKDELEKDAADCHWLRQFL
UniProt ID: O30640
Variant: V -> A at position 226-226
Variant annotation: in strain: NIH
Protein function: Methyltransferase involved in methanogenesis from methylamines methanol pathway. Catalyzes the transfer of the methyl group from the methylated corrinoid protein MtmC (MtmC1 or MtmC2) or MtbC to coenzyme M, forming the substrate for coenzyme-B sulfoethylthiotransferase.
Reference sequence:
MAEYTPKERLYRALRKQQVDRMPAVCFTQTATVEQMEACGAYWPEAHSDAEKMATLAEAAHTVVGFEAVRVPFDITAEAEFFGCGIKAGDLKQQPSVIKPSVKNLEDLEKLKNYNLKEGRIAVVLEAVKILSEKYGKELPIIGSMIGPFSLAQHINGDAWFGNLFTGEEVVPALLDFCSDFNVAYAKAMVENGADTIAIIDPTASYELIGGEFYEKYALPYQKKIVDAMKELDVATVLHICGNTTNGLGIMDKTGVNGISVDQKVDIKTATGSVKNAIIVGNLDPVAVLWNGTPEEIAEASKKALDAGVGLLTVGCGTVSMTPTVNLQKMIECAKSHTY
UniProt ID: O30640
Variant: G -> E at position 249-249
Variant annotation: in strain: NIH
Protein function: Methyltransferase involved in methanogenesis from methylamines methanol pathway. Catalyzes the transfer of the methyl group from the methylated corrinoid protein MtmC (MtmC1 or MtmC2) or MtbC to coenzyme M, forming the substrate for coenzyme-B sulfoethylthiotransferase.
Reference sequence:
MAEYTPKERLYRALRKQQVDRMPAVCFTQTATVEQMEACGAYWPEAHSDAEKMATLAEAAHTVVGFEAVRVPFDITAEAEFFGCGIKAGDLKQQPSVIKPSVKNLEDLEKLKNYNLKEGRIAVVLEAVKILSEKYGKELPIIGSMIGPFSLAQHINGDAWFGNLFTGEEVVPALLDFCSDFNVAYAKAMVENGADTIAIIDPTASYELIGGEFYEKYALPYQKKIVDAMKELDVATVLHICGNTTNGLGIMDKTGVNGISVDQKVDIKTATGSVKNAIIVGNLDPVAVLWNGTPEEIAEASKKALDAGVGLLTVGCGTVSMTPTVNLQKMIECAKSHTY
UniProt ID: O31357
Variant: G -> D at position 22-22
Variant annotation: in strain: PLi
Protein function: Not known; immunogenic protein.
Reference sequence:
MNKLLLLILFECIIFLSCSGKGSLESGIPKVSVIVNGTFDDKSFNESALNGIKKVKEEFKIELVLKESSTNSYLSDLEGLKDAGSNLIWLIGYRFSDVAKAVSLQNPEIKYAIIDPVYSEEPIPTNLVGMTFRAQEGAFLTGYIAAKVSKTGKIGFLGGIEGEIVDAFRYGYEAGAKYANKDIKISAHYIGSFNDVEAGRSVATKMYSDGIDIIHHAASLGGIGAIEVAKELGSGHYIIGVDEDQSYLAPNNIITSATKDVGRSLNIFTSNYLKTNTFEGGRLINYGLKEGVVGFVKNPKMIPFELEKEIDNLSSKIINQEIIVPYNKESYEKFLKE
UniProt ID: O31357
Variant: S -> N at position 26-26
Variant annotation: in strain: PLi
Protein function: Not known; immunogenic protein.
Reference sequence:
MNKLLLLILFECIIFLSCSGKGSLESGIPKVSVIVNGTFDDKSFNESALNGIKKVKEEFKIELVLKESSTNSYLSDLEGLKDAGSNLIWLIGYRFSDVAKAVSLQNPEIKYAIIDPVYSEEPIPTNLVGMTFRAQEGAFLTGYIAAKVSKTGKIGFLGGIEGEIVDAFRYGYEAGAKYANKDIKISAHYIGSFNDVEAGRSVATKMYSDGIDIIHHAASLGGIGAIEVAKELGSGHYIIGVDEDQSYLAPNNIITSATKDVGRSLNIFTSNYLKTNTFEGGRLINYGLKEGVVGFVKNPKMIPFELEKEIDNLSSKIINQEIIVPYNKESYEKFLKE
UniProt ID: O31357
Variant: P -> S at position 107-107
Variant annotation: in strain: PLi
Protein function: Not known; immunogenic protein.
Reference sequence:
MNKLLLLILFECIIFLSCSGKGSLESGIPKVSVIVNGTFDDKSFNESALNGIKKVKEEFKIELVLKESSTNSYLSDLEGLKDAGSNLIWLIGYRFSDVAKAVSLQNPEIKYAIIDPVYSEEPIPTNLVGMTFRAQEGAFLTGYIAAKVSKTGKIGFLGGIEGEIVDAFRYGYEAGAKYANKDIKISAHYIGSFNDVEAGRSVATKMYSDGIDIIHHAASLGGIGAIEVAKELGSGHYIIGVDEDQSYLAPNNIITSATKDVGRSLNIFTSNYLKTNTFEGGRLINYGLKEGVVGFVKNPKMIPFELEKEIDNLSSKIINQEIIVPYNKESYEKFLKE
UniProt ID: O31357
Variant: T -> A at position 125-125
Variant annotation: in strain: PLi
Protein function: Not known; immunogenic protein.
Reference sequence:
MNKLLLLILFECIIFLSCSGKGSLESGIPKVSVIVNGTFDDKSFNESALNGIKKVKEEFKIELVLKESSTNSYLSDLEGLKDAGSNLIWLIGYRFSDVAKAVSLQNPEIKYAIIDPVYSEEPIPTNLVGMTFRAQEGAFLTGYIAAKVSKTGKIGFLGGIEGEIVDAFRYGYEAGAKYANKDIKISAHYIGSFNDVEAGRSVATKMYSDGIDIIHHAASLGGIGAIEVAKELGSGHYIIGVDEDQSYLAPNNIITSATKDVGRSLNIFTSNYLKTNTFEGGRLINYGLKEGVVGFVKNPKMIPFELEKEIDNLSSKIINQEIIVPYNKESYEKFLKE
UniProt ID: O31357
Variant: N -> D at position 194-194
Variant annotation: in strain: PLi
Protein function: Not known; immunogenic protein.
Reference sequence:
MNKLLLLILFECIIFLSCSGKGSLESGIPKVSVIVNGTFDDKSFNESALNGIKKVKEEFKIELVLKESSTNSYLSDLEGLKDAGSNLIWLIGYRFSDVAKAVSLQNPEIKYAIIDPVYSEEPIPTNLVGMTFRAQEGAFLTGYIAAKVSKTGKIGFLGGIEGEIVDAFRYGYEAGAKYANKDIKISAHYIGSFNDVEAGRSVATKMYSDGIDIIHHAASLGGIGAIEVAKELGSGHYIIGVDEDQSYLAPNNIITSATKDVGRSLNIFTSNYLKTNTFEGGRLINYGLKEGVVGFVKNPKMIPFELEKEIDNLSSKIINQEIIVPYNKESYEKFLKE
UniProt ID: O31357
Variant: S -> G at position 219-219
Variant annotation: in strain: PLi
Protein function: Not known; immunogenic protein.
Reference sequence:
MNKLLLLILFECIIFLSCSGKGSLESGIPKVSVIVNGTFDDKSFNESALNGIKKVKEEFKIELVLKESSTNSYLSDLEGLKDAGSNLIWLIGYRFSDVAKAVSLQNPEIKYAIIDPVYSEEPIPTNLVGMTFRAQEGAFLTGYIAAKVSKTGKIGFLGGIEGEIVDAFRYGYEAGAKYANKDIKISAHYIGSFNDVEAGRSVATKMYSDGIDIIHHAASLGGIGAIEVAKELGSGHYIIGVDEDQSYLAPNNIITSATKDVGRSLNIFTSNYLKTNTFEGGRLINYGLKEGVVGFVKNPKMIPFELEKEIDNLSSKIINQEIIVPYNKESYEKFLKE
UniProt ID: O31357
Variant: I -> V at position 253-253
Variant annotation: in strain: PLi
Protein function: Not known; immunogenic protein.
Reference sequence:
MNKLLLLILFECIIFLSCSGKGSLESGIPKVSVIVNGTFDDKSFNESALNGIKKVKEEFKIELVLKESSTNSYLSDLEGLKDAGSNLIWLIGYRFSDVAKAVSLQNPEIKYAIIDPVYSEEPIPTNLVGMTFRAQEGAFLTGYIAAKVSKTGKIGFLGGIEGEIVDAFRYGYEAGAKYANKDIKISAHYIGSFNDVEAGRSVATKMYSDGIDIIHHAASLGGIGAIEVAKELGSGHYIIGVDEDQSYLAPNNIITSATKDVGRSLNIFTSNYLKTNTFEGGRLINYGLKEGVVGFVKNPKMIPFELEKEIDNLSSKIINQEIIVPYNKESYEKFLKE
UniProt ID: O31357
Variant: A -> S at position 257-257
Variant annotation: in strain: PLi
Protein function: Not known; immunogenic protein.
Reference sequence:
MNKLLLLILFECIIFLSCSGKGSLESGIPKVSVIVNGTFDDKSFNESALNGIKKVKEEFKIELVLKESSTNSYLSDLEGLKDAGSNLIWLIGYRFSDVAKAVSLQNPEIKYAIIDPVYSEEPIPTNLVGMTFRAQEGAFLTGYIAAKVSKTGKIGFLGGIEGEIVDAFRYGYEAGAKYANKDIKISAHYIGSFNDVEAGRSVATKMYSDGIDIIHHAASLGGIGAIEVAKELGSGHYIIGVDEDQSYLAPNNIITSATKDVGRSLNIFTSNYLKTNTFEGGRLINYGLKEGVVGFVKNPKMIPFELEKEIDNLSSKIINQEIIVPYNKESYEKFLKE
UniProt ID: O31357
Variant: S -> A at position 264-264
Variant annotation: in strain: PLi
Protein function: Not known; immunogenic protein.
Reference sequence:
MNKLLLLILFECIIFLSCSGKGSLESGIPKVSVIVNGTFDDKSFNESALNGIKKVKEEFKIELVLKESSTNSYLSDLEGLKDAGSNLIWLIGYRFSDVAKAVSLQNPEIKYAIIDPVYSEEPIPTNLVGMTFRAQEGAFLTGYIAAKVSKTGKIGFLGGIEGEIVDAFRYGYEAGAKYANKDIKISAHYIGSFNDVEAGRSVATKMYSDGIDIIHHAASLGGIGAIEVAKELGSGHYIIGVDEDQSYLAPNNIITSATKDVGRSLNIFTSNYLKTNTFEGGRLINYGLKEGVVGFVKNPKMIPFELEKEIDNLSSKIINQEIIVPYNKESYEKFLKE
UniProt ID: O31357
Variant: N -> S at position 271-271
Variant annotation: in strain: PLi
Protein function: Not known; immunogenic protein.
Reference sequence:
MNKLLLLILFECIIFLSCSGKGSLESGIPKVSVIVNGTFDDKSFNESALNGIKKVKEEFKIELVLKESSTNSYLSDLEGLKDAGSNLIWLIGYRFSDVAKAVSLQNPEIKYAIIDPVYSEEPIPTNLVGMTFRAQEGAFLTGYIAAKVSKTGKIGFLGGIEGEIVDAFRYGYEAGAKYANKDIKISAHYIGSFNDVEAGRSVATKMYSDGIDIIHHAASLGGIGAIEVAKELGSGHYIIGVDEDQSYLAPNNIITSATKDVGRSLNIFTSNYLKTNTFEGGRLINYGLKEGVVGFVKNPKMIPFELEKEIDNLSSKIINQEIIVPYNKESYEKFLKE
UniProt ID: O32266
Variant: M -> A at position 69-69
Variant annotation: in strain: 3610
Protein function: Required for swarm cell differentiation. Plays a crucial role in regulating the degree of cell flagellation.
Reference sequence:
MKRASIVREKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTNVESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLSNVTLWMTQER
UniProt ID: O32437
Variant: H -> Q at position 3-3
Variant annotation: in strain: CU741
Protein function: Negatively regulates the transcription of the comG operon.
Reference sequence:
MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFTTVMAEAYELGKSDAKSETE
UniProt ID: O33421
Variant: T -> S at position 166-166
Variant annotation: in strain: PA103 and CS32
Protein function: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. Essential for motility. Responsible for adhesion to mucin, which is the initial event in colonization by this organism of the airways of cystic fibrosis patients.
Reference sequence:
MANSTTINGYNSGLDIKNIVSTLVAAEKAPKEAQLKRLESDTTAKFTGIGQLKSAISDLQTILKELNKPELFQKRSASTSDEKFATATATKDALPGIYKLEVTQLASVSKVATASFADGYKTTSGGTLTIKQGADDAGVTVNVAAGATLAEVRDSLNAQLKDKGITANIVNNPGDGTSRLVFTGKDSGAGKDVFVQGSSGLENFNIGSVGADGKLTLSQLDGTSSSSSGYITQAKNAKFSIDGLTLESPTNTVDKVINGVTFELKTVTDTNKPITISVEQDRGGVKDNIKKFVEAYNKLVGVTSELTGVTKVGDDKAPVVGALVGDSSVRNLLTTMRNEMVQPGQGTDVRMLADMGITTKKDGTLEIDDKKLDKVLKDKFESVSALFTGDTGLMKRLDDKLTPYTQTGGVLQQRLDGLQDTIKSVDTQREALNRRVEQLQDRLLKQFTAMDQLIGQLNQTSGRMAQALSSLPGLVKKS
UniProt ID: O33421
Variant: K -> R at position 235-235
Variant annotation: in strain: PA103
Protein function: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. Essential for motility. Responsible for adhesion to mucin, which is the initial event in colonization by this organism of the airways of cystic fibrosis patients.
Reference sequence:
MANSTTINGYNSGLDIKNIVSTLVAAEKAPKEAQLKRLESDTTAKFTGIGQLKSAISDLQTILKELNKPELFQKRSASTSDEKFATATATKDALPGIYKLEVTQLASVSKVATASFADGYKTTSGGTLTIKQGADDAGVTVNVAAGATLAEVRDSLNAQLKDKGITANIVNNPGDGTSRLVFTGKDSGAGKDVFVQGSSGLENFNIGSVGADGKLTLSQLDGTSSSSSGYITQAKNAKFSIDGLTLESPTNTVDKVINGVTFELKTVTDTNKPITISVEQDRGGVKDNIKKFVEAYNKLVGVTSELTGVTKVGDDKAPVVGALVGDSSVRNLLTTMRNEMVQPGQGTDVRMLADMGITTKKDGTLEIDDKKLDKVLKDKFESVSALFTGDTGLMKRLDDKLTPYTQTGGVLQQRLDGLQDTIKSVDTQREALNRRVEQLQDRLLKQFTAMDQLIGQLNQTSGRMAQALSSLPGLVKKS
UniProt ID: O33421
Variant: TDVRML -> DLQACV at position 347-352
Variant annotation: in strain: DG1
Protein function: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. Essential for motility. Responsible for adhesion to mucin, which is the initial event in colonization by this organism of the airways of cystic fibrosis patients.
Reference sequence:
MANSTTINGYNSGLDIKNIVSTLVAAEKAPKEAQLKRLESDTTAKFTGIGQLKSAISDLQTILKELNKPELFQKRSASTSDEKFATATATKDALPGIYKLEVTQLASVSKVATASFADGYKTTSGGTLTIKQGADDAGVTVNVAAGATLAEVRDSLNAQLKDKGITANIVNNPGDGTSRLVFTGKDSGAGKDVFVQGSSGLENFNIGSVGADGKLTLSQLDGTSSSSSGYITQAKNAKFSIDGLTLESPTNTVDKVINGVTFELKTVTDTNKPITISVEQDRGGVKDNIKKFVEAYNKLVGVTSELTGVTKVGDDKAPVVGALVGDSSVRNLLTTMRNEMVQPGQGTDVRMLADMGITTKKDGTLEIDDKKLDKVLKDKFESVSALFTGDTGLMKRLDDKLTPYTQTGGVLQQRLDGLQDTIKSVDTQREALNRRVEQLQDRLLKQFTAMDQLIGQLNQTSGRMAQALSSLPGLVKKS
UniProt ID: O33421
Variant: E -> Q at position 430-430
Variant annotation: in strain: PA103 and CS32
Protein function: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. Essential for motility. Responsible for adhesion to mucin, which is the initial event in colonization by this organism of the airways of cystic fibrosis patients.
Reference sequence:
MANSTTINGYNSGLDIKNIVSTLVAAEKAPKEAQLKRLESDTTAKFTGIGQLKSAISDLQTILKELNKPELFQKRSASTSDEKFATATATKDALPGIYKLEVTQLASVSKVATASFADGYKTTSGGTLTIKQGADDAGVTVNVAAGATLAEVRDSLNAQLKDKGITANIVNNPGDGTSRLVFTGKDSGAGKDVFVQGSSGLENFNIGSVGADGKLTLSQLDGTSSSSSGYITQAKNAKFSIDGLTLESPTNTVDKVINGVTFELKTVTDTNKPITISVEQDRGGVKDNIKKFVEAYNKLVGVTSELTGVTKVGDDKAPVVGALVGDSSVRNLLTTMRNEMVQPGQGTDVRMLADMGITTKKDGTLEIDDKKLDKVLKDKFESVSALFTGDTGLMKRLDDKLTPYTQTGGVLQQRLDGLQDTIKSVDTQREALNRRVEQLQDRLLKQFTAMDQLIGQLNQTSGRMAQALSSLPGLVKKS
UniProt ID: O33421
Variant: N -> D at position 433-433
Variant annotation: in strain: PA103
Protein function: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. Essential for motility. Responsible for adhesion to mucin, which is the initial event in colonization by this organism of the airways of cystic fibrosis patients.
Reference sequence:
MANSTTINGYNSGLDIKNIVSTLVAAEKAPKEAQLKRLESDTTAKFTGIGQLKSAISDLQTILKELNKPELFQKRSASTSDEKFATATATKDALPGIYKLEVTQLASVSKVATASFADGYKTTSGGTLTIKQGADDAGVTVNVAAGATLAEVRDSLNAQLKDKGITANIVNNPGDGTSRLVFTGKDSGAGKDVFVQGSSGLENFNIGSVGADGKLTLSQLDGTSSSSSGYITQAKNAKFSIDGLTLESPTNTVDKVINGVTFELKTVTDTNKPITISVEQDRGGVKDNIKKFVEAYNKLVGVTSELTGVTKVGDDKAPVVGALVGDSSVRNLLTTMRNEMVQPGQGTDVRMLADMGITTKKDGTLEIDDKKLDKVLKDKFESVSALFTGDTGLMKRLDDKLTPYTQTGGVLQQRLDGLQDTIKSVDTQREALNRRVEQLQDRLLKQFTAMDQLIGQLNQTSGRMAQALSSLPGLVKKS
UniProt ID: O33641
Variant: F -> L at position 6-6
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Protease responsible for the cleavage of IcsA between 'Arg-758' and 'Arg-759', removing the entire alpha domain from IscA localized on the bacterial surface. This proteolytic activity contributes to the maintenance of a tight polar cap of IcsA, which is important to Shigella actin-based motility.
Reference sequence:
MKLKFFVLALCVPAIFTTHATTNYPLFIPDNISTDISLGSLSGKTKERVYHPKEGGRKISQLDWKYSNATIVRGGIDWKLIPKVSFGVSGWTTLGNQKASMVDKDWNNSNTPQVWTDQSWHPNTHLRDANEFELNLKGWLLNNLDYRLGLIAGYQESRYSFNAMGGSYIYSENGGSRNKKGAHPSGERTIGYKQLFKIPYIGLTANYRHENFEFGAELKYSGWVLSSDTDKHYQTETIFKDEIKNQNYCSVAANIGYYVTPSAKFYIEGSRNYISNKKGDTSLYEQSTNISGTIKNSASIEYIGFLTSAGIKYIF
UniProt ID: O33641
Variant: S -> N at position 176-176
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Protease responsible for the cleavage of IcsA between 'Arg-758' and 'Arg-759', removing the entire alpha domain from IscA localized on the bacterial surface. This proteolytic activity contributes to the maintenance of a tight polar cap of IcsA, which is important to Shigella actin-based motility.
Reference sequence:
MKLKFFVLALCVPAIFTTHATTNYPLFIPDNISTDISLGSLSGKTKERVYHPKEGGRKISQLDWKYSNATIVRGGIDWKLIPKVSFGVSGWTTLGNQKASMVDKDWNNSNTPQVWTDQSWHPNTHLRDANEFELNLKGWLLNNLDYRLGLIAGYQESRYSFNAMGGSYIYSENGGSRNKKGAHPSGERTIGYKQLFKIPYIGLTANYRHENFEFGAELKYSGWVLSSDTDKHYQTETIFKDEIKNQNYCSVAANIGYYVTPSAKFYIEGSRNYISNKKGDTSLYEQSTNISGTIKNSASIEYIGFLTSAGIKYIF
UniProt ID: O33641
Variant: A -> T at position 182-182
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Protease responsible for the cleavage of IcsA between 'Arg-758' and 'Arg-759', removing the entire alpha domain from IscA localized on the bacterial surface. This proteolytic activity contributes to the maintenance of a tight polar cap of IcsA, which is important to Shigella actin-based motility.
Reference sequence:
MKLKFFVLALCVPAIFTTHATTNYPLFIPDNISTDISLGSLSGKTKERVYHPKEGGRKISQLDWKYSNATIVRGGIDWKLIPKVSFGVSGWTTLGNQKASMVDKDWNNSNTPQVWTDQSWHPNTHLRDANEFELNLKGWLLNNLDYRLGLIAGYQESRYSFNAMGGSYIYSENGGSRNKKGAHPSGERTIGYKQLFKIPYIGLTANYRHENFEFGAELKYSGWVLSSDTDKHYQTETIFKDEIKNQNYCSVAANIGYYVTPSAKFYIEGSRNYISNKKGDTSLYEQSTNISGTIKNSASIEYIGFLTSAGIKYIF