sujigwak/NVAR huggingface dataset:
UniProt ID: Q9V3R1
Variant: T -> A at position 758-758
Variant annotation: in strain: SENGWA37 and SENGWA51
Protein function: Responsible for physiological and behavioral changes in mated female flies. Associates with sperm and localizes to specific regions of the female reproductive tract, including the sperm storage organs. It accelerates sperm accumulation into storage but does not mediate the entry of the first sperm into storage. Once sperm storage has initiated it seems to act as a guidance factor helping subsequent sperm move into storage, a corral concentrating sperm around the SSO entrances and/or a trigger for responses within the female that accelerate storage of sperm.
Reference sequence:
MWTLTCQQFIALILLGTLVPSESFLCKHCFRKNLEKVHESFRDILSPPIFGVNPQPLIEVQQPKVTPKPESSQVIHVHQPQVILKPIYYPKVDTISTKNQIGIHGPYSQYPSLLPSANLLGIPNQQLINAQDVLSDKDQKQTQVQNNNLHIRFGVSALREGRNNPSLETISRDKVDKISPALQLQLLRYADSQSQSQTQSQSASQSESNASSQFQAQEQSNRLLENPPVSESQSQSESQSQSESQKQSQSQSQRQQQIQTQLQILRQLQQKSNEQSAAQSASQIQSQRQSDSQSNLQLQEQSQSQSEQGKPIQSQIQILQGLQQKELDDKSASQSQSESKTRQEQQKQLNLQQLEELSSSLSQSRLGLGQQIQSQLQKNQLDKQFASQFQSQSKSQLEQQMQLQLQSLRQLQQKQLDEQSASQSQPQSQVAQQIQSHLQLLRLLQSRLKTQSALKSDLEQQILLQLKKLTEVQQKQLAEQPTLRPSSKSQSPGQLEQQILLQLQNLLQFQQNQLKSDTQTQSQLQESKSNSLSQSQSQSQEQLQLQRDQNLRQLEQIKLEMQNIRELLQKGKSELQTQSDSQRRIHELYQNILQLNKEKLSYQLKQLKLKELEDQKKSQAEISKGSNPSNLFIIGQLPSEGKPAPGNQGPSIEPKLVPQPGSLDKLPSGGGLIGKPASTGLYILSPDFNDLSDYRDQFRLQQELKKHQNILSLLQRRQNDIKKQQNAQLLLGQQQKEQQAQESINKQQSSSAGSSSQTKLQQDIQSTGAQGSQQGLQAGSTGLQTSSLQGTESSASQSAALQRLKEQEQLRIQTENDQKTSSSSSHSNSQNSQSSSSQSSQASQSEAQRQEAGNRNTLLLDQSSSKTQSESKSESSSQSSSHSSSQSTSNSSSNVQSKLQGESQALLNNLSG
UniProt ID: Q9V3R1
Variant: Q -> E at position 830-830
Variant annotation: in strain: WSII26
Protein function: Responsible for physiological and behavioral changes in mated female flies. Associates with sperm and localizes to specific regions of the female reproductive tract, including the sperm storage organs. It accelerates sperm accumulation into storage but does not mediate the entry of the first sperm into storage. Once sperm storage has initiated it seems to act as a guidance factor helping subsequent sperm move into storage, a corral concentrating sperm around the SSO entrances and/or a trigger for responses within the female that accelerate storage of sperm.
Reference sequence:
MWTLTCQQFIALILLGTLVPSESFLCKHCFRKNLEKVHESFRDILSPPIFGVNPQPLIEVQQPKVTPKPESSQVIHVHQPQVILKPIYYPKVDTISTKNQIGIHGPYSQYPSLLPSANLLGIPNQQLINAQDVLSDKDQKQTQVQNNNLHIRFGVSALREGRNNPSLETISRDKVDKISPALQLQLLRYADSQSQSQTQSQSASQSESNASSQFQAQEQSNRLLENPPVSESQSQSESQSQSESQKQSQSQSQRQQQIQTQLQILRQLQQKSNEQSAAQSASQIQSQRQSDSQSNLQLQEQSQSQSEQGKPIQSQIQILQGLQQKELDDKSASQSQSESKTRQEQQKQLNLQQLEELSSSLSQSRLGLGQQIQSQLQKNQLDKQFASQFQSQSKSQLEQQMQLQLQSLRQLQQKQLDEQSASQSQPQSQVAQQIQSHLQLLRLLQSRLKTQSALKSDLEQQILLQLKKLTEVQQKQLAEQPTLRPSSKSQSPGQLEQQILLQLQNLLQFQQNQLKSDTQTQSQLQESKSNSLSQSQSQSQEQLQLQRDQNLRQLEQIKLEMQNIRELLQKGKSELQTQSDSQRRIHELYQNILQLNKEKLSYQLKQLKLKELEDQKKSQAEISKGSNPSNLFIIGQLPSEGKPAPGNQGPSIEPKLVPQPGSLDKLPSGGGLIGKPASTGLYILSPDFNDLSDYRDQFRLQQELKKHQNILSLLQRRQNDIKKQQNAQLLLGQQQKEQQAQESINKQQSSSAGSSSQTKLQQDIQSTGAQGSQQGLQAGSTGLQTSSLQGTESSASQSAALQRLKEQEQLRIQTENDQKTSSSSSHSNSQNSQSSSSQSSQASQSEAQRQEAGNRNTLLLDQSSSKTQSESKSESSSQSSSHSSSQSTSNSSSNVQSKLQGESQALLNNLSG
UniProt ID: Q9V3R1
Variant: Q -> R at position 844-844
Variant annotation: in strain: WSII16
Protein function: Responsible for physiological and behavioral changes in mated female flies. Associates with sperm and localizes to specific regions of the female reproductive tract, including the sperm storage organs. It accelerates sperm accumulation into storage but does not mediate the entry of the first sperm into storage. Once sperm storage has initiated it seems to act as a guidance factor helping subsequent sperm move into storage, a corral concentrating sperm around the SSO entrances and/or a trigger for responses within the female that accelerate storage of sperm.
Reference sequence:
MWTLTCQQFIALILLGTLVPSESFLCKHCFRKNLEKVHESFRDILSPPIFGVNPQPLIEVQQPKVTPKPESSQVIHVHQPQVILKPIYYPKVDTISTKNQIGIHGPYSQYPSLLPSANLLGIPNQQLINAQDVLSDKDQKQTQVQNNNLHIRFGVSALREGRNNPSLETISRDKVDKISPALQLQLLRYADSQSQSQTQSQSASQSESNASSQFQAQEQSNRLLENPPVSESQSQSESQSQSESQKQSQSQSQRQQQIQTQLQILRQLQQKSNEQSAAQSASQIQSQRQSDSQSNLQLQEQSQSQSEQGKPIQSQIQILQGLQQKELDDKSASQSQSESKTRQEQQKQLNLQQLEELSSSLSQSRLGLGQQIQSQLQKNQLDKQFASQFQSQSKSQLEQQMQLQLQSLRQLQQKQLDEQSASQSQPQSQVAQQIQSHLQLLRLLQSRLKTQSALKSDLEQQILLQLKKLTEVQQKQLAEQPTLRPSSKSQSPGQLEQQILLQLQNLLQFQQNQLKSDTQTQSQLQESKSNSLSQSQSQSQEQLQLQRDQNLRQLEQIKLEMQNIRELLQKGKSELQTQSDSQRRIHELYQNILQLNKEKLSYQLKQLKLKELEDQKKSQAEISKGSNPSNLFIIGQLPSEGKPAPGNQGPSIEPKLVPQPGSLDKLPSGGGLIGKPASTGLYILSPDFNDLSDYRDQFRLQQELKKHQNILSLLQRRQNDIKKQQNAQLLLGQQQKEQQAQESINKQQSSSAGSSSQTKLQQDIQSTGAQGSQQGLQAGSTGLQTSSLQGTESSASQSAALQRLKEQEQLRIQTENDQKTSSSSSHSNSQNSQSSSSQSSQASQSEAQRQEAGNRNTLLLDQSSSKTQSESKSESSSQSSSHSSSQSTSNSSSNVQSKLQGESQALLNNLSG
UniProt ID: Q9V6Q2
Variant: AA -> TS at position 113-114
Variant annotation: in strain: Tai 255.1
Protein function: Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore . Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation . May serve as an epigenetic mark that propagates centromere identity through replication and cell division .
Reference sequence:
MPRHSRAKRAPRPSANNSKSPNDDDTAFRSPEPEDGTDYGLEFTTSQLTLQDNNRRSSTLRRDAGRRQPAARDSSTSGEEEDQENRYPTTRSPQTRRMTVQQESKTRAAGPVAAQNQTRRRKAANPMSRAKRMDREIRRLQHHPGTLIPKLPFSRLVREFIVKYSDDEPLRVTEGALLAMQESCEMYLTQRLADSYMLTKHRNRVTLEVRDMALMAYICDRGRQF
UniProt ID: Q9V751
Variant: A -> D at position 108-108
Variant annotation: in strain: 2CPA-7
Protein function: Hemolymph antibacterial protein.
Reference sequence:
MQKTSILILALFAIAEAVPTTGPIRVRRQVLGGSLASNPAGGADARLNLSKGIGNPNHNVVGQVFAAGNTQSGPVTTGGTLAYNNAGHGASLTKTHTPGVKDVFQQEAHANLFNNGRHNLDAKVFASQNKLANGFEFQRNGAGLDYSHINGHGASLTHSNFPGIGQQLGLDGRANLWSSPNRATTLDLTGSASKWTSGPFANQKPNFGAGLGLSHHFG
UniProt ID: Q9V751
Variant: Q -> P at position 138-138
Variant annotation: in strain: 2CPA-122
Protein function: Hemolymph antibacterial protein.
Reference sequence:
MQKTSILILALFAIAEAVPTTGPIRVRRQVLGGSLASNPAGGADARLNLSKGIGNPNHNVVGQVFAAGNTQSGPVTTGGTLAYNNAGHGASLTKTHTPGVKDVFQQEAHANLFNNGRHNLDAKVFASQNKLANGFEFQRNGAGLDYSHINGHGASLTHSNFPGIGQQLGLDGRANLWSSPNRATTLDLTGSASKWTSGPFANQKPNFGAGLGLSHHFG
UniProt ID: Q9V8Y2
Variant: T -> A at position 15-15
Variant annotation: in strain: 304A, 319A, 375A, 773A, 774A, 813A, 852A and 859A
Protein function: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Reference sequence:
MNSYFVIALSALFVTLAVGSSLNLSDEQKDLAKQHREQCAEEVKLTEEEKAKVNAKDFNNPTENIKCFANCFFEKVGTLKDGELQESVVLEKLGALIGEEKTKAALEKCRTIKGENKCDTASKLYDCFESFKPAPEAKA
UniProt ID: Q9V8Y2
Variant: V -> M at position 88-88
Variant annotation: in strain: 301A, 306A, 313A, 315A, 318A, 322A, 324A, 332A, 357A, 390A, 399A, 732A, 735A, 736A, 737A, 797A, 799A, 808A, 820A, 822A, 838A and 868A
Protein function: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Reference sequence:
MNSYFVIALSALFVTLAVGSSLNLSDEQKDLAKQHREQCAEEVKLTEEEKAKVNAKDFNNPTENIKCFANCFFEKVGTLKDGELQESVVLEKLGALIGEEKTKAALEKCRTIKGENKCDTASKLYDCFESFKPAPEAKA
UniProt ID: Q9V8Y2
Variant: T -> S at position 120-120
Variant annotation: in strain: 907A
Protein function: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Reference sequence:
MNSYFVIALSALFVTLAVGSSLNLSDEQKDLAKQHREQCAEEVKLTEEEKAKVNAKDFNNPTENIKCFANCFFEKVGTLKDGELQESVVLEKLGALIGEEKTKAALEKCRTIKGENKCDTASKLYDCFESFKPAPEAKA
UniProt ID: Q9VAI6
Variant: F -> L at position 13-13
Variant annotation: in strain: 386A and 387A
Protein function: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Reference sequence:
MKVLIVLLLGLAFVLADHHHHHHDYVVKTHEDLTNYRTQCVEKVHASEELVEKYKKWQYPDDAVTHCYLECIFQKFGFYDTEHGFDVHKIHIQLAGPGVEVHESDEVHQKIAHCAETHSKEGDSCSKAYHAGMCFMNSNLQLVQHSVKV
UniProt ID: Q9VAI6
Variant: H -> P at position 19-19
Variant annotation: in strain: 405A
Protein function: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Reference sequence:
MKVLIVLLLGLAFVLADHHHHHHDYVVKTHEDLTNYRTQCVEKVHASEELVEKYKKWQYPDDAVTHCYLECIFQKFGFYDTEHGFDVHKIHIQLAGPGVEVHESDEVHQKIAHCAETHSKEGDSCSKAYHAGMCFMNSNLQLVQHSVKV
UniProt ID: Q9VAI6
Variant: T -> A at position 38-38
Variant annotation: in strain: 509A
Protein function: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Reference sequence:
MKVLIVLLLGLAFVLADHHHHHHDYVVKTHEDLTNYRTQCVEKVHASEELVEKYKKWQYPDDAVTHCYLECIFQKFGFYDTEHGFDVHKIHIQLAGPGVEVHESDEVHQKIAHCAETHSKEGDSCSKAYHAGMCFMNSNLQLVQHSVKV
UniProt ID: Q9VAI6
Variant: E -> D at position 82-82
Variant annotation: in strain: 10A, 100A, 101A, 149A, 158A, 189A, 195A, 223A, 233A, 237A, 28A, 303A, 312A, 319A, 324A, 325A, 32A, 335A, 340A, 348A, 350A, 352A, 356A, 358A, 359A, 360A, 362A, 365A, 367A, 371A, 380A, 383A, 386A, 387A, 390A, 393A, 398A, 40A, 405A, 41A, 443A, 486A, 514A, 517A, 528A, 554A, 59A, 627A, 639A, 672A, 703A, 707A, 712A, 730A, 739A, 761A, 762A, 767A, 770A, 786A, 788A, 793A, 804A, 820A, 833A, 834A, 836A, 849A, 850A, 851A, 852A, 853A and 855A
Protein function: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Reference sequence:
MKVLIVLLLGLAFVLADHHHHHHDYVVKTHEDLTNYRTQCVEKVHASEELVEKYKKWQYPDDAVTHCYLECIFQKFGFYDTEHGFDVHKIHIQLAGPGVEVHESDEVHQKIAHCAETHSKEGDSCSKAYHAGMCFMNSNLQLVQHSVKV
UniProt ID: Q9VAI6
Variant: T -> S at position 117-117
Variant annotation: in strain: 10A, 336A, 338A, 581A, 663A, 786A and 911A
Protein function: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Reference sequence:
MKVLIVLLLGLAFVLADHHHHHHDYVVKTHEDLTNYRTQCVEKVHASEELVEKYKKWQYPDDAVTHCYLECIFQKFGFYDTEHGFDVHKIHIQLAGPGVEVHESDEVHQKIAHCAETHSKEGDSCSKAYHAGMCFMNSNLQLVQHSVKV
UniProt ID: Q9VAI6
Variant: L -> R at position 140-140
Variant annotation: in strain: 788A
Protein function: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Reference sequence:
MKVLIVLLLGLAFVLADHHHHHHDYVVKTHEDLTNYRTQCVEKVHASEELVEKYKKWQYPDDAVTHCYLECIFQKFGFYDTEHGFDVHKIHIQLAGPGVEVHESDEVHQKIAHCAETHSKEGDSCSKAYHAGMCFMNSNLQLVQHSVKV
UniProt ID: Q9VAJ4
Variant: K -> R at position 49-49
Variant annotation: in strain: 88A, 195A, 217A, 223A, 233A, 256A, 360A, 380A, 482A, 554A, 639A, 716A, 790A, 820A and 855A
Protein function: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Reference sequence:
MKVFVAICVLIGLASADYVVKNRHDMLAYRDECVKELAVPVDLVEKYQKWEYPNDAKTQCYIKCVFTKWGLFDVQSGFNVENIHQQLVGNHADHNEAFHASLAACVDKNEQGSNACEWAYRGATCLLKENLAQIQKSLAPKA
UniProt ID: Q9VAJ4
Variant: A -> G at position 139-139
Variant annotation: in strain: 40A, 822A and 832A
Protein function: Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid.
Reference sequence:
MKVFVAICVLIGLASADYVVKNRHDMLAYRDECVKELAVPVDLVEKYQKWEYPNDAKTQCYIKCVFTKWGLFDVQSGFNVENIHQQLVGNHADHNEAFHASLAACVDKNEQGSNACEWAYRGATCLLKENLAQIQKSLAPKA
UniProt ID: Q9VE00
Variant: I -> V at position 208-208
Variant annotation: in strain: Subline 5
Protein function: Has a role in resistance to insecticide lufenuron, but no other insecticides.
Reference sequence:
MLKVRSALSLIQSQKATLSLATQKRWQTNVATAEAREDSEWLQAKPFEQIPRLNMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVRPENEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALINLPNIPLKFKFIDLPN
UniProt ID: Q9VE00
Variant: I -> T at position 252-252
Variant annotation: in strain: Subline 5 and Subline 7
Protein function: Has a role in resistance to insecticide lufenuron, but no other insecticides.
Reference sequence:
MLKVRSALSLIQSQKATLSLATQKRWQTNVATAEAREDSEWLQAKPFEQIPRLNMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVRPENEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALINLPNIPLKFKFIDLPN
UniProt ID: Q9VE00
Variant: E -> G at position 289-289
Variant annotation: in strain: Subline 5
Protein function: Has a role in resistance to insecticide lufenuron, but no other insecticides.
Reference sequence:
MLKVRSALSLIQSQKATLSLATQKRWQTNVATAEAREDSEWLQAKPFEQIPRLNMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVRPENEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALINLPNIPLKFKFIDLPN
UniProt ID: Q9VE00
Variant: D -> G at position 295-295
Variant annotation: in strain: Subline 8
Protein function: Has a role in resistance to insecticide lufenuron, but no other insecticides.
Reference sequence:
MLKVRSALSLIQSQKATLSLATQKRWQTNVATAEAREDSEWLQAKPFEQIPRLNMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVRPENEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALINLPNIPLKFKFIDLPN
UniProt ID: Q9VE00
Variant: V -> A at position 417-417
Variant annotation: in strain: Subline 8
Protein function: Has a role in resistance to insecticide lufenuron, but no other insecticides.
Reference sequence:
MLKVRSALSLIQSQKATLSLATQKRWQTNVATAEAREDSEWLQAKPFEQIPRLNMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVRPENEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALINLPNIPLKFKFIDLPN
UniProt ID: Q9VE00
Variant: L -> P at position 499-499
Variant annotation: in strain: Subline 7
Protein function: Has a role in resistance to insecticide lufenuron, but no other insecticides.
Reference sequence:
MLKVRSALSLIQSQKATLSLATQKRWQTNVATAEAREDSEWLQAKPFEQIPRLNMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFLSTHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVLMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLEAPDDFIDTINRWTLESVSVVALDKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQEVTLAYVDEAIERLDKEAKEGVVRPENEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPEKQARLREEVMKVLPNKNSEFTEASMKNVPYLRACIKESQRLHPLIVGNARVLARDAVLSGYRVPAGTYVNIVPLNALTRDEYFPQASEFLPERWLRSPKDSESKCPANELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALINLPNIPLKFKFIDLPN
UniProt ID: Q9VF30
Variant: Y -> H at position 118-118
Protein function: Required for meiotic DNA recombination in females. Probably not involved in DNA repair and recombination in somatic cells.
Reference sequence:
MNPTLSRGGAPSRFVRGRGRGGGAYRPYFYFRRNGRVIPAGGNRQPNQGEPGAPDAPSVPPATRQPRGWSRTAGKRGRNAHLDCSFLRPENYAAPEDGLQVQSIAVDNPRAYSGWRLYFLREKYEEGNELATRIMAVEAYYQRNPHTFDFVMIRDRGFFPLCAAGIKSDAQLKEVWPSLSEDIREHPLRTLGTLSLAMHTVVVNHQLDCNDSTTAMVSTPEQYVLPTPRVRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMRQRGTFQPRPYQCKRSECVARDEFVPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMPAEMDVELRHDLVDAVRVGQEVVVTGILKLQELGDDTTTGDTSNQMQPYLKAVSIRDASSIKREFSERDLEAIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGGKGAETEAINVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVTFAGRNKRVLQAGSLMMASGGGHCTLDDVDKLASKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSERDMSLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSLKEGSSRQGTRGGGGAGGGAGKSAQLRNFLELTKRRSAALGRRIFEFDELKEIGTRAGILTGFSQLVEMANLGGYLLMKGANMYEVVPD
UniProt ID: Q9VF30
Variant: V -> A at position 422-422
Protein function: Required for meiotic DNA recombination in females. Probably not involved in DNA repair and recombination in somatic cells.
Reference sequence:
MNPTLSRGGAPSRFVRGRGRGGGAYRPYFYFRRNGRVIPAGGNRQPNQGEPGAPDAPSVPPATRQPRGWSRTAGKRGRNAHLDCSFLRPENYAAPEDGLQVQSIAVDNPRAYSGWRLYFLREKYEEGNELATRIMAVEAYYQRNPHTFDFVMIRDRGFFPLCAAGIKSDAQLKEVWPSLSEDIREHPLRTLGTLSLAMHTVVVNHQLDCNDSTTAMVSTPEQYVLPTPRVRKIYARPDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQMEIAMRQRGTFQPRPYQCKRSECVARDEFVPLRSSPYTRLSIRQIIRVEESSLNLVHDFETSMPAEMDVELRHDLVDAVRVGQEVVVTGILKLQELGDDTTTGDTSNQMQPYLKAVSIRDASSIKREFSERDLEAIVMINAEPNSFKLLVQSIAPEVYGHELPKAACLLSLLGGKGAETEAINVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVTFAGRNKRVLQAGSLMMASGGGHCTLDDVDKLASKQAVLLQCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDEGRYLLQNINISPSLLREFHLVYILLDKPSERDMSLTAHVRALHAGARKRARIAARYALKPKMSDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYARQELNPVLNEDASNAVLRYFLELKGSCNLDEDVSSQIGAGQLLAIIHLSQARARLDLSHVVSPQHVRDVIALLTESITQTSLKEGSSRQGTRGGGGAGGGAGKSAQLRNFLELTKRRSAALGRRIFEFDELKEIGTRAGILTGFSQLVEMANLGGYLLMKGANMYEVVPD
UniProt ID: Q9VKD7
Variant: L -> V at position 2-2
Variant annotation: in strain: MEL20, ZBMEL131, ZBMEL186, ZBMEL384 and ZBMEL398
Protein function: Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Involved in trans-silencing effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin via its role in piRNA biogenesis.
Reference sequence:
MLITQIIMKQIRDYPIVSTISIAVSTVLASEVIWKLVQCSRSKREKASRVHEVIIFNELGEICAAVHMRNSSMGSQKPQVSPCCNTHCSLRNVAKIVEQIDRAVYSIDLAIYTFTSLFLADSIKRALQRGVIIRIISDGEMVYSKGSQISMLAQLGVPVRVPITTNLMHNKFCIIDGFERVEEIRLLRKLKFMRPCYSIVISGSVNWTALGLGGNWENCIITADDKLTATFQAEFQRMWRAFAKTEGSQIQLK
UniProt ID: Q9VKD7
Variant: D -> E at position 225-225
Variant annotation: in strain: =MEL01, MEL02, MEL11, MEL12, MEL14, MEL15, MEL16, MEL17, MEL18, MEL19, MEL20, ZBMEL82, ZBMEL95, ZBMEL131, ZBMEL145, ZBMEL157, ZBMEL186, ZBMEL191, ZBMEL229, ZBMEL377, ZBMEL384 and ZBMEL398
Protein function: Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Involved in trans-silencing effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin via its role in piRNA biogenesis.
Reference sequence:
MLITQIIMKQIRDYPIVSTISIAVSTVLASEVIWKLVQCSRSKREKASRVHEVIIFNELGEICAAVHMRNSSMGSQKPQVSPCCNTHCSLRNVAKIVEQIDRAVYSIDLAIYTFTSLFLADSIKRALQRGVIIRIISDGEMVYSKGSQISMLAQLGVPVRVPITTNLMHNKFCIIDGFERVEEIRLLRKLKFMRPCYSIVISGSVNWTALGLGGNWENCIITADDKLTATFQAEFQRMWRAFAKTEGSQIQLK
UniProt ID: Q9VKD7
Variant: L -> V at position 252-252
Variant annotation: in strain: ZBMEL191, ZBMEL229, ZBMEL377 and ZBMEL384
Protein function: Cardiolipin hydrolase present at the mitochondrial outer membrane required for piRNA metabolic process. Acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting the piRNA metabolic process. Plays a key role in primary biogenesis of piRNAs and is required during oogenesis to repress transposable elements and prevent their mobilization. piRNAs mediate the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Involved in trans-silencing effect (TSE), a homology-dependent repression mechanism by which a P-transgene inserted in subtelomeric heterochromatin via its role in piRNA biogenesis.
Reference sequence:
MLITQIIMKQIRDYPIVSTISIAVSTVLASEVIWKLVQCSRSKREKASRVHEVIIFNELGEICAAVHMRNSSMGSQKPQVSPCCNTHCSLRNVAKIVEQIDRAVYSIDLAIYTFTSLFLADSIKRALQRGVIIRIISDGEMVYSKGSQISMLAQLGVPVRVPITTNLMHNKFCIIDGFERVEEIRLLRKLKFMRPCYSIVISGSVNWTALGLGGNWENCIITADDKLTATFQAEFQRMWRAFAKTEGSQIQLK
UniProt ID: Q9VN45
Variant: I -> V at position 325-325
Variant annotation: in RNA edited version
Protein function: During postembryonic development, functions with endocytic adapter Eps-15 in neurons to restrain synaptic growth, by inhibiting BMP signaling, and to control synaptic endocytosis. Required presynaptically for neuromuscular junction (NMJ) neurotransmission. Inhibits neuronal BMP signaling by promoting endocytic internalization and subsequent endosomal trafficking of the BMP receptor wit. In this way, regulates the Fmr1 translational regulator controlling Futsch expression to modulate neuronal microtubule stability, which controls both synaptogenesis and neuronal survival.
Reference sequence:
MAEEESEFLEAYAGIRTAYKAAMTQVDLAVSHEEQESPGQAIVAYELALRMIEDTFGIPVGLPNKIDTVQAEWNDACALIQKLKSAETELRYRLKVLRSQKQSIDDSAVEATEESRAEMDTKRPPLLAENPSTQYGIANASGAPKTYRELAAGLRELLAVRDAKVLLDELFRAQVKMYRIEASGSVTTISGSSTMSLVMCTVGGKWKYLSGIYFIQCSMPNEGTAGIWLYPLVPSITNCYQTEYGAFIFPDMECQQPGNAFGLMLTKEGQTSRTEDELEDLQQFFLDLLEAVLAGTVVQLKSPTSQRAGLASDTVSGSEQVSRHIVSAADFIASNLVRGAEKTGGFMLRSTPYIISKMTPASMDAQVPSSVQTSVEVAQKVTHAAAGMTGWIAGKVGTASMAVGRYLAPHIQEQGSKLLQKGFGYDTSEANSTMEGAMTIAAGAVEGVSTVFDGLETSAKILGSSLSENSVKIIEHKYGQQTGNLASGTFDTVGNVFVVSQNVNYITPKGIAKKMVKRTGEAVVSDYKRDLRKSESHYINAGSLYPDLRALKE