sujigwak/NVAR huggingface dataset:
UniProt ID: Q07337
Variant: L -> V at position 56-56
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: ALLS -> TLLA at position 64-67
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: IAAKAIGKKIHQNNGLDTENNH -> VAKKAIGNLIAQNGLNAGANQ at position 72-93
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: A -> V at position 103-103
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: KQ -> AE at position 109-110
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: EG -> SEE at position 118-119
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: DA -> ED at position 125-126
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: SET -> NKA at position 131-133
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: N -> D at position 136-136
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: EKHTD -> SSHAE at position 140-144
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: KEGV -> IANGAA at position 147-150
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: DAKE -> NAKA at position 154-157
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: T -> D at position 167-167
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: EELG -> QELE at position 171-174
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: EV -> KN at position 181-182
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: KEMLA -> QETLN at position 188-192
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07337
Variant: S -> N at position 206-206
Variant annotation: in strain: 2591
Protein function: A major immunodominant protein in mammalian hosts . Required for the initial stages of mammalian infection . Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo . Inhibits macrophage-mediated phagocytosis of the bacteria . Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue . Binds human complement C4-B, which may inhibit the complement cascade  (Probable). Experiments in mice suggest it may play another role after initial infection  (Probable).
Reference sequence:
MKKNTLSAILMTLFLFISCNNSGKDGNTSANSADESVKGPNLTEISKKITDSNAVLLAVKEVEALLSSIDEIAAKAIGKKIHQNNGLDTENNHNGSLLAGAYAISTLIKQKLDGLKNEGLKEKIDAAKKCSETFTNKLKEKHTDLGKEGVTDADAKEAILKTNGTKTKGAEELGKLFESVEVLSKAAKEMLANSVKELTSPVVAESPKKP
UniProt ID: Q07343
Variant: S -> C at position 703-703
Variant annotation: in dbSNP:rs2227297
Protein function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes . May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Reference sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
UniProt ID: Q07444
Variant: S -> N at position 2-2
Variant annotation: in dbSNP:rs2682489
Protein function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Reference sequence:
MSKQRGTFSEVSLAQDPKWQQRKPKGNKSSISGTEQEIFQVELNLQNASLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNSSPNARTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLQACASKNSSSLLCIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHEIKDSDHAERNCAMLHVRGLISDQCGSSRIIRRGFIMLTRLVLNS
UniProt ID: Q07444
Variant: W -> P at position 19-19
Variant annotation: in allele NKG2-E*01 and allele NKG2-E*03; requires 2 nucleotide substitutions; dbSNP:rs796361824
Protein function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Reference sequence:
MSKQRGTFSEVSLAQDPKWQQRKPKGNKSSISGTEQEIFQVELNLQNASLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNSSPNARTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLQACASKNSSSLLCIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHEIKDSDHAERNCAMLHVRGLISDQCGSSRIIRRGFIMLTRLVLNS
UniProt ID: Q07444
Variant: W -> R at position 19-19
Variant annotation: in allele NKG2-E*02; dbSNP:rs2682490
Protein function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Reference sequence:
MSKQRGTFSEVSLAQDPKWQQRKPKGNKSSISGTEQEIFQVELNLQNASLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNSSPNARTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLQACASKNSSSLLCIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHEIKDSDHAERNCAMLHVRGLISDQCGSSRIIRRGFIMLTRLVLNS
UniProt ID: Q07444
Variant: A -> T at position 106-106
Variant annotation: in dbSNP:rs28626640
Protein function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Reference sequence:
MSKQRGTFSEVSLAQDPKWQQRKPKGNKSSISGTEQEIFQVELNLQNASLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNSSPNARTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLQACASKNSSSLLCIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHEIKDSDHAERNCAMLHVRGLISDQCGSSRIIRRGFIMLTRLVLNS
UniProt ID: Q07444
Variant: H -> P at position 113-113
Variant annotation: in dbSNP:rs2682494
Protein function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Reference sequence:
MSKQRGTFSEVSLAQDPKWQQRKPKGNKSSISGTEQEIFQVELNLQNASLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNSSPNARTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLQACASKNSSSLLCIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHEIKDSDHAERNCAMLHVRGLISDQCGSSRIIRRGFIMLTRLVLNS
UniProt ID: Q07444
Variant: R -> S at position 135-135
Variant annotation: in dbSNP:rs1138437
Protein function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Reference sequence:
MSKQRGTFSEVSLAQDPKWQQRKPKGNKSSISGTEQEIFQVELNLQNASLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNSSPNARTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLQACASKNSSSLLCIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHEIKDSDHAERNCAMLHVRGLISDQCGSSRIIRRGFIMLTRLVLNS
UniProt ID: Q07444
Variant: C -> S at position 155-155
Variant annotation: in dbSNP:rs2682495
Protein function: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Reference sequence:
MSKQRGTFSEVSLAQDPKWQQRKPKGNKSSISGTEQEIFQVELNLQNASLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNSSPNARTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLQACASKNSSSLLCIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHEIKDSDHAERNCAMLHVRGLISDQCGSSRIIRRGFIMLTRLVLNS
UniProt ID: Q07566
Variant: KH -> NQ at position 27-28
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Converts phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) to PtdIns 5-P. IpgD is injected by Shigella into the host cell and is required for invasion. The accumulation of PtdIns 5-P causes membrane ruffling and actin cytoskeleton rearrangements at the entry site. Acts in concert with IpaA to coordinate and control the membrane and cytoskeletal rearrangements induced early after invasion of the host cell.
Reference sequence:
MHITNLGLHQVSFQSGDSYKGAEETGKHKGVSVISYQRVKNGERNKGIEALNRLYLQNQTSLTGKSLLFARDKAEVFCEAIKLAGGDTSKIKAMMERLDTYKLGEVNKRHINELNKVISEEIRAQLGIKNKKELQTKIKQIFTDYLNNKNWGPVNKNISHHGKNYSFQLTPASHMKIGNKNIFVKEYNGKGICCASTRERDHIANMWLSKVVDDEGKEIFSGIRHGVISAYGLKKNSSERAVAARNKAEELVSAALYSRPELLSQALSGKTVDLKIVSTSLLTPTSLTGGEESMLKDQVSALKGLNSKRGGPTKLLIRNSDGLLKEVSVNLKVVTFNFGVNELALKMGLGWRNVDKLNDESICSLLGDNFLKNGVIGGWAAEAIEKNPPCKNDVIYLANQIKEIVNNKLQKNDNGEPYKLSQRVTLLAYTIGAVPCWNCKSGKDRTGMQDAEIKREIIRKHETGQFSQLNSKLSSEEKRLFSTILMNSGNMEIQEMNTGVPGNKVMKKLPLSSLELSYSERIGDPKIWNMVKGYSSFV
UniProt ID: Q07566
Variant: I -> V at position 48-48
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Converts phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) to PtdIns 5-P. IpgD is injected by Shigella into the host cell and is required for invasion. The accumulation of PtdIns 5-P causes membrane ruffling and actin cytoskeleton rearrangements at the entry site. Acts in concert with IpaA to coordinate and control the membrane and cytoskeletal rearrangements induced early after invasion of the host cell.
Reference sequence:
MHITNLGLHQVSFQSGDSYKGAEETGKHKGVSVISYQRVKNGERNKGIEALNRLYLQNQTSLTGKSLLFARDKAEVFCEAIKLAGGDTSKIKAMMERLDTYKLGEVNKRHINELNKVISEEIRAQLGIKNKKELQTKIKQIFTDYLNNKNWGPVNKNISHHGKNYSFQLTPASHMKIGNKNIFVKEYNGKGICCASTRERDHIANMWLSKVVDDEGKEIFSGIRHGVISAYGLKKNSSERAVAARNKAEELVSAALYSRPELLSQALSGKTVDLKIVSTSLLTPTSLTGGEESMLKDQVSALKGLNSKRGGPTKLLIRNSDGLLKEVSVNLKVVTFNFGVNELALKMGLGWRNVDKLNDESICSLLGDNFLKNGVIGGWAAEAIEKNPPCKNDVIYLANQIKEIVNNKLQKNDNGEPYKLSQRVTLLAYTIGAVPCWNCKSGKDRTGMQDAEIKREIIRKHETGQFSQLNSKLSSEEKRLFSTILMNSGNMEIQEMNTGVPGNKVMKKLPLSSLELSYSERIGDPKIWNMVKGYSSFV
UniProt ID: Q07566
Variant: S -> G at position 66-66
Variant annotation: in plasmid pINV_F6_M1382
Protein function: Converts phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) to PtdIns 5-P. IpgD is injected by Shigella into the host cell and is required for invasion. The accumulation of PtdIns 5-P causes membrane ruffling and actin cytoskeleton rearrangements at the entry site. Acts in concert with IpaA to coordinate and control the membrane and cytoskeletal rearrangements induced early after invasion of the host cell.
Reference sequence:
MHITNLGLHQVSFQSGDSYKGAEETGKHKGVSVISYQRVKNGERNKGIEALNRLYLQNQTSLTGKSLLFARDKAEVFCEAIKLAGGDTSKIKAMMERLDTYKLGEVNKRHINELNKVISEEIRAQLGIKNKKELQTKIKQIFTDYLNNKNWGPVNKNISHHGKNYSFQLTPASHMKIGNKNIFVKEYNGKGICCASTRERDHIANMWLSKVVDDEGKEIFSGIRHGVISAYGLKKNSSERAVAARNKAEELVSAALYSRPELLSQALSGKTVDLKIVSTSLLTPTSLTGGEESMLKDQVSALKGLNSKRGGPTKLLIRNSDGLLKEVSVNLKVVTFNFGVNELALKMGLGWRNVDKLNDESICSLLGDNFLKNGVIGGWAAEAIEKNPPCKNDVIYLANQIKEIVNNKLQKNDNGEPYKLSQRVTLLAYTIGAVPCWNCKSGKDRTGMQDAEIKREIIRKHETGQFSQLNSKLSSEEKRLFSTILMNSGNMEIQEMNTGVPGNKVMKKLPLSSLELSYSERIGDPKIWNMVKGYSSFV