sujigwak/NVAR huggingface dataset:
UniProt ID: P0DH90
Variant: G -> E at position 146-146
Variant annotation: in strain: cv. Edi-0
Protein function: Required for the regulation of flowering time in the late-flowering phenotype. Involved in the enrichment of a WDR5A-containing COMPASS-like complex at the 'FLOWERING LOCUS C' that trimethylates histone H3 'Lys-4', leading to FLC up-regulation and RNA levels increase . Variants with an early-flowering phenotype (Including cv. Columbia, cv. Landsberg Erecta and cv. Wassilewskija) show loss-of-function mutations of FRI. Able to delay flowering independently of FRL1 activity. Dispensable for the reactivation of FLC in early embryogenesis, but required to maintain high levels of FLC expression in later embryonic and vegetative development. Suppresses the repression of FLC by the autonomous pathway, but has no effect on the expression of the genes involved in this pathway.
Reference sequence:
MSNYPPTVAAQPTTTANPLLQRHQSEQRRRELPKIVETESTSMDITIGQSKQPQFLKSIDELAAFSVAVETFKRQFDDLQKHIESIENAIDSKLESNGVVLAARNNNFHQPMLSPPRNNVSVETTVTVSQPSQEIVPETSNKPEGGRMCELMCSKGLRKYIYANISDQAKLMEEIPSALKLAKEPAKFVLDCIGKFYLQGRRAFTKESPMSSARQVSLLILESFLLMPDRGKGKVKIESWIKDEAETAAVAWRKRLMTEGGLAAAEKMDARGLLLLVACFGVPSNFRSTDLLDLIRMSGSNEIAGALKRSQFLVPMVSGIVESSIKRGMHIEALEMVYTFGMEDKFSAALVLTSFLKMSKESFERAKRKAQSPLAFKEAATKQLAVLSSVMQCMETHKLDPAKELPGWQIKEQIVSLEKDTLQLDKEMEEKARSLSLMEEAALAKRMYNQQIKRPRLSPMEMPPVTSSSYSPIYRDRSFPSQRDDDQDEISALVSSYLGPSTSFPHRSRRSPEYMVPLPHGGLGRSVYAYEHLAPNSYSPGHGHRLHRQYSPSLVHGQRHPLQYSPPIHGQQQLPYGIQRVYRHSPSEERYLGLSNQRSPRSNSSLDPK
UniProt ID: P0DH90
Variant: M -> I at position 148-148
Variant annotation: in strain: cv. Edi-0
Protein function: Required for the regulation of flowering time in the late-flowering phenotype. Involved in the enrichment of a WDR5A-containing COMPASS-like complex at the 'FLOWERING LOCUS C' that trimethylates histone H3 'Lys-4', leading to FLC up-regulation and RNA levels increase . Variants with an early-flowering phenotype (Including cv. Columbia, cv. Landsberg Erecta and cv. Wassilewskija) show loss-of-function mutations of FRI. Able to delay flowering independently of FRL1 activity. Dispensable for the reactivation of FLC in early embryogenesis, but required to maintain high levels of FLC expression in later embryonic and vegetative development. Suppresses the repression of FLC by the autonomous pathway, but has no effect on the expression of the genes involved in this pathway.
Reference sequence:
MSNYPPTVAAQPTTTANPLLQRHQSEQRRRELPKIVETESTSMDITIGQSKQPQFLKSIDELAAFSVAVETFKRQFDDLQKHIESIENAIDSKLESNGVVLAARNNNFHQPMLSPPRNNVSVETTVTVSQPSQEIVPETSNKPEGGRMCELMCSKGLRKYIYANISDQAKLMEEIPSALKLAKEPAKFVLDCIGKFYLQGRRAFTKESPMSSARQVSLLILESFLLMPDRGKGKVKIESWIKDEAETAAVAWRKRLMTEGGLAAAEKMDARGLLLLVACFGVPSNFRSTDLLDLIRMSGSNEIAGALKRSQFLVPMVSGIVESSIKRGMHIEALEMVYTFGMEDKFSAALVLTSFLKMSKESFERAKRKAQSPLAFKEAATKQLAVLSSVMQCMETHKLDPAKELPGWQIKEQIVSLEKDTLQLDKEMEEKARSLSLMEEAALAKRMYNQQIKRPRLSPMEMPPVTSSSYSPIYRDRSFPSQRDDDQDEISALVSSYLGPSTSFPHRSRRSPEYMVPLPHGGLGRSVYAYEHLAPNSYSPGHGHRLHRQYSPSLVHGQRHPLQYSPPIHGQQQLPYGIQRVYRHSPSEERYLGLSNQRSPRSNSSLDPK
UniProt ID: P0DI94
Variant: VH -> IS at position 59-60
Variant annotation: in strain: 83-210
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYTGSDRKGWDKGARFALMFNTNSETELGTLGTYTQLRFNYTSNNSRHDGQYGDFSDDRDVADGGVSTGTDLQFAYITLGGFKVGIDESEFHTFTGYLGDVINDDVVAAGSYRTGKIAYTFTGGNGFSAVIALEQGGEDVDNDYTIDGYMPHVVGGLKYAGGWGSIAGAVAYDPVIEEWATKVRGDVNITDRFSVWLQGAYSSAATPNQNYGQWGGDWAVWGGAKFIATEKVTFNLQAAHDDWGKTAVTANVAYQLVPGFTITPEVSYTKFGGEWKDTVAEDNAWGGIVRFQRSF
UniProt ID: P0DI94
Variant: DR -> SV at position 130-131
Variant annotation: in strain: 83-210
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYTGSDRKGWDKGARFALMFNTNSETELGTLGTYTQLRFNYTSNNSRHDGQYGDFSDDRDVADGGVSTGTDLQFAYITLGGFKVGIDESEFHTFTGYLGDVINDDVVAAGSYRTGKIAYTFTGGNGFSAVIALEQGGEDVDNDYTIDGYMPHVVGGLKYAGGWGSIAGAVAYDPVIEEWATKVRGDVNITDRFSVWLQGAYSSAATPNQNYGQWGGDWAVWGGAKFIATEKVTFNLQAAHDDWGKTAVTANVAYQLVPGFTITPEVSYTKFGGEWKDTVAEDNAWGGIVRFQRSF
UniProt ID: P0DI94
Variant: S -> N at position 139-139
Variant annotation: in strain: 83-210
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYTGSDRKGWDKGARFALMFNTNSETELGTLGTYTQLRFNYTSNNSRHDGQYGDFSDDRDVADGGVSTGTDLQFAYITLGGFKVGIDESEFHTFTGYLGDVINDDVVAAGSYRTGKIAYTFTGGNGFSAVIALEQGGEDVDNDYTIDGYMPHVVGGLKYAGGWGSIAGAVAYDPVIEEWATKVRGDVNITDRFSVWLQGAYSSAATPNQNYGQWGGDWAVWGGAKFIATEKVTFNLQAAHDDWGKTAVTANVAYQLVPGFTITPEVSYTKFGGEWKDTVAEDNAWGGIVRFQRSF
UniProt ID: P0DI94
Variant: A -> V at position 241-241
Variant annotation: in strain: 83-210
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYTGSDRKGWDKGARFALMFNTNSETELGTLGTYTQLRFNYTSNNSRHDGQYGDFSDDRDVADGGVSTGTDLQFAYITLGGFKVGIDESEFHTFTGYLGDVINDDVVAAGSYRTGKIAYTFTGGNGFSAVIALEQGGEDVDNDYTIDGYMPHVVGGLKYAGGWGSIAGAVAYDPVIEEWATKVRGDVNITDRFSVWLQGAYSSAATPNQNYGQWGGDWAVWGGAKFIATEKVTFNLQAAHDDWGKTAVTANVAYQLVPGFTITPEVSYTKFGGEWKDTVAEDNAWGGIVRFQRSF
UniProt ID: P0DI94
Variant: P -> S at position 246-246
Variant annotation: in strain: 83-210
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYTGSDRKGWDKGARFALMFNTNSETELGTLGTYTQLRFNYTSNNSRHDGQYGDFSDDRDVADGGVSTGTDLQFAYITLGGFKVGIDESEFHTFTGYLGDVINDDVVAAGSYRTGKIAYTFTGGNGFSAVIALEQGGEDVDNDYTIDGYMPHVVGGLKYAGGWGSIAGAVAYDPVIEEWATKVRGDVNITDRFSVWLQGAYSSAATPNQNYGQWGGDWAVWGGAKFIATEKVTFNLQAAHDDWGKTAVTANVAYQLVPGFTITPEVSYTKFGGEWKDTVAEDNAWGGIVRFQRSF
UniProt ID: P0DI94
Variant: V -> A at position 304-304
Variant annotation: in strain: 83-210
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYTGSDRKGWDKGARFALMFNTNSETELGTLGTYTQLRFNYTSNNSRHDGQYGDFSDDRDVADGGVSTGTDLQFAYITLGGFKVGIDESEFHTFTGYLGDVINDDVVAAGSYRTGKIAYTFTGGNGFSAVIALEQGGEDVDNDYTIDGYMPHVVGGLKYAGGWGSIAGAVAYDPVIEEWATKVRGDVNITDRFSVWLQGAYSSAATPNQNYGQWGGDWAVWGGAKFIATEKVTFNLQAAHDDWGKTAVTANVAYQLVPGFTITPEVSYTKFGGEWKDTVAEDNAWGGIVRFQRSF
UniProt ID: P0DI96
Variant: VH -> IS at position 59-60
Variant annotation: in strain: Fr7
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF
UniProt ID: P0DI96
Variant: SGT -> TGS at position 75-77
Variant annotation: in strain: 686, De12, Fr7, Pt1 and Thomsen
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF
UniProt ID: P0DI96
Variant: K -> N at position 80-80
Variant annotation: in strain: Fr11 and Wf21
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF
UniProt ID: P0DI96
Variant: S -> G at position 85-85
Variant annotation: in strain: De12, Fr7, Pt1 and Thomsen
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF
UniProt ID: P0DI96
Variant: RVSTG -> MFNTN at position 91-95
Variant annotation: in strain: De12, Fr7, Pt1 and Thomsen
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF
UniProt ID: P0DI96
Variant: SASNSREDGYYGTNSD -> AANNSGVDGKYGNETSS at position 114-129
Variant annotation: in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF
UniProt ID: P0DI96
Variant: Q -> E at position 134-134
Variant annotation: in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF
UniProt ID: P0DI96
Variant: Q -> H at position 153-153
Variant annotation: in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF
UniProt ID: P0DI96
Variant: T -> S at position 172-172
Variant annotation: in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF
UniProt ID: P0DI96
Variant: PVFKDSQGREINGRGYQ -> GTTNYH at position 206-222
Variant annotation: in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF
UniProt ID: P0DI96
Variant: T -> A at position 258-258
Variant annotation: in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF
UniProt ID: P0DI96
Variant: I -> V at position 339-339
Variant annotation: in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF
UniProt ID: P0DI96
Variant: SN -> GG at position 349-350
Variant annotation: in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF
UniProt ID: P0DI96
Variant: RELGNDTLDD -> NTVAEDN at position 354-363
Variant annotation: in strain: 686, De12, Fr7, Fr11, Pt1, Thomsen and Wf21
Protein function: Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Reference sequence:
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYSASNSREDGYYGTNSDGTVMQFAYIQLGGLRVGIDESEFQTFTGYLGDVINDDVISAGTYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTPVFKDSQGREINGRGYQIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTITPEVSYTKFSNEWKRELGNDTLDDAWGGIVRFQRSF
UniProt ID: P0DJ06
Variant: A -> G at position 9-9
Variant annotation: in allele SAP2-1
Protein function: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Induces host inflammatory cytokine production in a proteolytic activity-independent way. Plays a role in tissue damage during superficial infection. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein.
Reference sequence:
MFLKNIFIALAIALLVDATPTTTKRSAGFVALDFSVVKTPKAFPVTNGQEGKTSKRQAVPVTLHNEQVTYAADITVGSNNQKLNVIVDTGSSDLWVPDVNVDCQVTYSDQTADFCKQKGTYDPSGSSASQDLNTPFKIGYGDGSSSQGTLYKDTVGFGGVSIKNQVLADVDSTSIDQGILGVGYKTNEAGGSYDNVPVTLKKQGVIAKNAYSLYLNSPDAATGQIIFGGVDNAKYSGSLIALPVTSDRELRISLGSVEVSGKTINTDNVDVLVDSGTTITYLQQDLADQIIKAFNGKLTQDSNGNSFYEVDCNLSGDVVFNFSKNAKISVPASEFAASLQGDDGQPYDKCQLLFDVNDANILGDNFLRSAYIVYDLDDNEISLAQVKYTSASSISALT
UniProt ID: P0DJ06
Variant: V -> L at position 273-273
Variant annotation: in allele SAP2-1
Protein function: Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Induces host inflammatory cytokine production in a proteolytic activity-independent way. Plays a role in tissue damage during superficial infection. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal peptides generated from the host protein.
Reference sequence:
MFLKNIFIALAIALLVDATPTTTKRSAGFVALDFSVVKTPKAFPVTNGQEGKTSKRQAVPVTLHNEQVTYAADITVGSNNQKLNVIVDTGSSDLWVPDVNVDCQVTYSDQTADFCKQKGTYDPSGSSASQDLNTPFKIGYGDGSSSQGTLYKDTVGFGGVSIKNQVLADVDSTSIDQGILGVGYKTNEAGGSYDNVPVTLKKQGVIAKNAYSLYLNSPDAATGQIIFGGVDNAKYSGSLIALPVTSDRELRISLGSVEVSGKTINTDNVDVLVDSGTTITYLQQDLADQIIKAFNGKLTQDSNGNSFYEVDCNLSGDVVFNFSKNAKISVPASEFAASLQGDDGQPYDKCQLLFDVNDANILGDNFLRSAYIVYDLDDNEISLAQVKYTSASSISALT
UniProt ID: P0DJI8
Variant: G -> S at position 15-15
Variant annotation: in dbSNP:rs1232745554
Reference sequence:
MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGAWAAEVITDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY
UniProt ID: P0DJI8
Variant: A -> V at position 70-70
Variant annotation: in allele SAA1.1
Reference sequence:
MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGAWAAEVITDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY
UniProt ID: P0DJI8
Variant: V -> A at position 75-75
Variant annotation: in allele SAA1.1 and allele SAA1.3
Reference sequence:
MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGAWAAEVITDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY
UniProt ID: P0DJI8
Variant: T -> S at position 77-77
Variant annotation: in allele SAA1.5; requires 2 nucleotide substitutions; dbSNP:rs1671926
Reference sequence:
MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGAWAAEVITDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY
UniProt ID: P0DJI8
Variant: D -> N at position 78-78
Variant annotation: in allele SAA1.4; dbSNP:rs557915415
Reference sequence:
MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGAWAAEVITDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY
UniProt ID: P0DJI8
Variant: F -> L at position 86-86
Variant annotation: in dbSNP:rs1059559
Reference sequence:
MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGAWAAEVITDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY
UniProt ID: P0DJI8
Variant: G -> D at position 90-90
Variant annotation: in allele SAA1.2; dbSNP:rs79681911
Reference sequence:
MKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGAWAAEVITDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY
UniProt ID: P0DJI9
Variant: R -> H at position 89-89
Variant annotation: in allele SAA2.1; dbSNP:rs2229338
Protein function: Major acute phase reactant.
Reference sequence:
MKLLTGLVFCSLVLSVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGAWAAEVISNARENIQRLTGRGAEDSLADQAANKWGRSGRDPNHFRPAGLPEKY
UniProt ID: P0DJM0
Variant: K -> R at position 3-3
Variant annotation: in strain: H4
Protein function: Mediates the entry of L.monocytogenes into host intestinal epithelial cells; transformation with inlA alone allows L.innocua (a non-invasive species) to be taken up by host cells . Binds to human receptor cadherin-1 (E-cadherin, CDH1); the chicken homolog of cadherin-1 but not cadherin-2 function as receptors . Mouse cadherin-1 is not a receptor, however mutating a single surface-exposed residue (Glu-172 to Pro in mouse) allows cadherin-1 to act as a receptor for InlA .
Reference sequence:
MRKKRYVWLKSILVAILVFGSGVWINTSNGTNAQAATITQDTPINQIFTDTALAEKMKTVLGKTNVTDTVSQTDLDQVTTLQADRLGIKSIDGVEYLNNLTQINFSNNQLTDITPLKNLTKLVDILMNNNQIADITPLANLTNLTGLTLFNNQITDIDPLKNLTNLNRLELSSNTISDISALSGLTSLQQLSFGNQVTDLKPLANLTTLERLDISSNKVSDISVLAKLTNLESLIATNNQISDITPLGILTNLDELSLNGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQISNISPLAGLTALTNLELNENQLEDISPISNLKNLTYLTLYFNNISDISPVSSLTKLQRLFFYNNKVSDVSSLANLTNINWLSAGHNQISDLTPLANLTRITQLGLNDQAWTNAPVNYKANVSIPNTVKNVTGALIAPATISDGGSYTEPDITWNLPSYTNEVSYTFSQPVTIGKGTTTFSGTVTQPLKAIFNVKFHVDGKETTKEVEAGNLLTEPAKPVKEGHTFVGWFDAQTGGTKWNFSTDKMPTNDINLYAQFSINSYTATFDNDGVTTSQTVDYQGLLQEPTAPTKEGYTFKGWYDAKTGGDKWDFATSKMPAKNITLYAQYSANSYTATFDVDGKSTTQAVDYQGLLKEPKAPTKAGYTFKGWYDEKTDGKKWDFATDKMPANDITLYAQFTKNPVAPPTTGGNTPPTTNNGGNTTPPSANIPGSDTSNTSTGNSASTTSTMNAYDPYNSKEASLPTTGDSDNALYLLLGLLAVGTAMALTKKARASK
UniProt ID: P0DJM0
Variant: F -> L at position 19-19
Variant annotation: in strain: H4
Protein function: Mediates the entry of L.monocytogenes into host intestinal epithelial cells; transformation with inlA alone allows L.innocua (a non-invasive species) to be taken up by host cells . Binds to human receptor cadherin-1 (E-cadherin, CDH1); the chicken homolog of cadherin-1 but not cadherin-2 function as receptors . Mouse cadherin-1 is not a receptor, however mutating a single surface-exposed residue (Glu-172 to Pro in mouse) allows cadherin-1 to act as a receptor for InlA .
Reference sequence:
MRKKRYVWLKSILVAILVFGSGVWINTSNGTNAQAATITQDTPINQIFTDTALAEKMKTVLGKTNVTDTVSQTDLDQVTTLQADRLGIKSIDGVEYLNNLTQINFSNNQLTDITPLKNLTKLVDILMNNNQIADITPLANLTNLTGLTLFNNQITDIDPLKNLTNLNRLELSSNTISDISALSGLTSLQQLSFGNQVTDLKPLANLTTLERLDISSNKVSDISVLAKLTNLESLIATNNQISDITPLGILTNLDELSLNGNQLKDIGTLASLTNLTDLDLANNQISNLAPLSGLTKLTELKLGANQISNISPLAGLTALTNLELNENQLEDISPISNLKNLTYLTLYFNNISDISPVSSLTKLQRLFFYNNKVSDVSSLANLTNINWLSAGHNQISDLTPLANLTRITQLGLNDQAWTNAPVNYKANVSIPNTVKNVTGALIAPATISDGGSYTEPDITWNLPSYTNEVSYTFSQPVTIGKGTTTFSGTVTQPLKAIFNVKFHVDGKETTKEVEAGNLLTEPAKPVKEGHTFVGWFDAQTGGTKWNFSTDKMPTNDINLYAQFSINSYTATFDNDGVTTSQTVDYQGLLQEPTAPTKEGYTFKGWYDAKTGGDKWDFATSKMPAKNITLYAQYSANSYTATFDVDGKSTTQAVDYQGLLKEPKAPTKAGYTFKGWYDEKTDGKKWDFATDKMPANDITLYAQFTKNPVAPPTTGGNTPPTTNNGGNTTPPSANIPGSDTSNTSTGNSASTTSTMNAYDPYNSKEASLPTTGDSDNALYLLLGLLAVGTAMALTKKARASK