Well, it is this: that Mrs. Cavendish does not care, and never has cared one little jot about Dr. 
The doctor knows that Mrs. Cavendish does not care about him.
mnli hypothesis: The doctor knows that Mrs. Cavendish does not care about him. premise: Well, it is this: that Mrs. Cavendish does not care, and never has cared one little jot about Dr. 