Not opened up to full-scale settlement until after the Meiji Restoration of 1868, the island of Hokkaido is Japan's Far North. 
The Meiji Restoration did not involve Hokkaido whatsoever. 
mnli hypothesis: The Meiji Restoration did not involve Hokkaido whatsoever.  premise: Not opened up to full-scale settlement until after the Meiji Restoration of 1868, the island of Hokkaido is Japan's Far North. 