In its new building, the Project Arts Ceter, 39 East Essex Street, displays the most avant-garde in painting and sculpture; it has a performance space upstairs.
The Project Arts Centre was not always located in 39 East Essex Street. 
mnli hypothesis: The Project Arts Centre was not always located in 39 East Essex Street.  premise: In its new building, the Project Arts Ceter, 39 East Essex Street, displays the most avant-garde in painting and sculpture; it has a performance space upstairs.