The tomb was abandoned when Amenophis abandoned Thebes and made a new capital at Tell el-Amarna to the north.
Thebes was too small to be the capital for Amenophis.  
mnli hypothesis: Thebes was too small to be the capital for Amenophis.   premise: The tomb was abandoned when Amenophis abandoned Thebes and made a new capital at Tell el-Amarna to the north.