It shall come to pass in the latter days that the mountain of the house of the Lord shall be established as the highest of the mountains, and shall be lifted up above the hills; and all the nations shall flow to it,
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Now as he was walking beside the Sea of Galilee, he saw two brothers, Simon called Peter and his brother Andrew, throwing a casting net into the sea (for they were fishermen). And he said to them, “Follow me and I will make you fishers of people.” And immediately they left their nets and followed him. And going on from there, he saw two other brothers, James the son of Zebedee and his brother John, in the boat with their father Zebedee, mending their nets, and he called them. And immediately they left the boat and their father and followed him. And he went around through all of Galilee, teaching in their synagogues and proclaiming the good news of the kingdom and healing every disease and every sickness among the people.
And the scribes of the Pharisees, when they saw that he was eating with sinners and tax collectors, began to say to his disciples, “Why does he eat with tax collectors and sinners?”
Therefore, because we have been declared righteous by faith, we have peace with God through our Lord Jesus Christ,
But if indeed our gospel is veiled, it is veiled among those who are perishing, among whom the god of this age has blinded the minds of the unbelievers, so that they would not see the light of the gospel of the glory of Christ, who is the image of God.
And when they saw it, they all began to complain, saying, “He has gone in to find lodging with a man who is a sinner!”
Now when the Pharisee who invited him saw this, he spoke to himself, saying, “If this man were a prophet, he would have known who and what kind of woman this is who is touching him, that she is a sinner.”
For although I am free from all people, I have enslaved myself to all, in order that I may gain more. I have become like a Jew to the Jews, in order that I may gain the Jews. To those under the law I became as under the law (although I myself am not under the law) in order that I may gain those under the law. To those outside the law I became as outside the law (although I am not outside the law of God, but subject to the law of Christ) in order that I may gain those outside the law. To the weak I became weak, in order that I may gain the weak. I have become all things to all people, in order that by all means I may save some. I do all this for the sake of the gospel, in order that I may become a participant with it.
And he also said to the one who had invited him, “When you give a dinner or a banquet, do not invite your friends or your brothers or your relatives or wealthy neighbors, lest they also invite you in return, and repayment come to you. But whenever you give a banquet, invite the poor, the crippled, the lame, the blind, and you will be blessed, because they are not able to repay you. For it will be paid back to you at the resurrection of the righteous.” Now when one of those reclining at the table with him heard these things, he said to him, “Blessed is everyone who will eat bread in the kingdom of God!” But he said to him, “A certain man was giving a large banquet and invited many. And he sent his slave at the hour of the banquet to say to those who have been invited, ‘Come, because now it is ready!’ And they all alike began to excuse themselves. The first said to him, ‘I have purchased a field, and I must go out to look at it. I ask you, consider me excused.’ And another said, ‘I have purchased five yoke of oxen, and I am going to examine them. I ask you, consider me excused.’ And another said, ‘I have married a wife, and for this reason I am not able to come.’ And the slave came and reported these things to his master. Then the master of the house became angry and said to his slave, ‘Go out quickly into the streets and alleys of the city and bring in here the poor and crippled and blind and lame!’ And the slave said, ‘Sir, what you ordered has been done, and there is still room.’ And the master said to the slave, ‘Go out into the highways and hedges and press them to come in, so that my house will be filled! For I say to you that none of those persons who were invited will taste my banquet!’ ”
Waddlia chondrophila, an obligate intracellular bacterium belonging to the Chlamydiales order, is considered as an emerging pathogen. Some clinical studies highlighted a possible role of W. chondrophila in bronchiolitis, pneumonia and miscarriage. This pathogenic potential is further supported by the ability of W. chondrophila to infect and replicate within human pneumocytes, macrophages and endometrial cells. Considering that W. chondrophila might be a causative agent of respiratory tract infection, we developed a mouse model of respiratory tract infection to get insight into the pathogenesis of W. chondrophila. Following intranasal inoculation of 2 x 108 W. chondrophila, mice lost up to 40% of their body weight, and succumbed rapidly from infection with a death rate reaching 50% at day 4 post-inoculation. Bacterial loads, estimated by qPCR, increased from day 0 to day 3 post-infection and decreased thereafter in surviving mice. Bacterial growth was confirmed by detecting dividing bacteria using electron microscopy, and living bacteria were isolated from lungs 14 days post-infection. Immunohistochemistry and histopathology of infected lungs revealed the presence of bacteria associated with pneumonia characterized by an important multifocal inflammation. The high inflammatory score in the lungs was associated with the presence of pro-inflammatory cytokines in both serum and lungs at day 3 post-infection. This animal model supports the role of W. chondrophila as an agent of respiratory tract infection, and will help understanding the pathogenesis of this strict intracellular bacterium.