In a large collaborative screening project, 370 men with idiopathic azoospermia or severe oligozoospermia were analysed for deletions of 76 DNA loci in Yq11. In 12 individuals, we observed de novo… (More)
Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary…
The Drosophila gene sine oculis (so), a nuclear homeoprotein that is required for eye development, has several homologues in vertebrates (the SIX gene family). Among them, SIX3 is considered to be… (More)
Msx1 is a regulatory gene involved in epithelio-mesenchymal interactions in limb formation and organogenesis. In the embryonic CNS, the Msx1 gene is expressed along the dorsal midline. Msx1 mutant… (More)
Limited knowledge currently exists regarding the roles of plant genes and proteins in the Agrobacterium tumefaciens-mediated transformation process. To understand the host contribution to… (More)
The human pseudoautosomal region comprises a 2.6 megabase segment of the distal short arms of the X and Y chromosomes. Complete DNA sequence homology between the two sex chromosomes is found in this… (More)
The Drosophila gene sine oculis (so) is a nuclear homeoprotein that is required for eye development. Homologous genes to so, denoted SIX genes, have been found in vertebrates. Among the SIX genes,… (More)
The region of whole Zea mays plants most susceptible to Agrobacterium–mediated transfer of infectious maize streak virus has been identified. Injection of a suspension of bacterial cells in… (More)
We consider the problem of labeling the nodes of a graph in a way that will allow one to compute the distance between any two nodes directly from their labels (without using any additional… (More)
Several papers describe linear time algorithms to preprocess a tree, such that one can answer subsequent nearest common ancestor queries in constant time. Here, we survey these algorithms and related… (More)
Θk-graphs are geometric graphs that appear in the context of graph navigation. The shortest-path metric of these graphs is known to approximate the Euclidean complete graph up to a factor depending… (More)
Several papers describe linear time algorithms to preprocess a tree, in order to answer subsequent nearest common ancestor queries in constant time. Here, we survey these algorithms and related… (More)
This paper deals with the length of a Robertson–Seymour’s tree-decomposition. The tree-length of a graph is the largest distance between two vertices of a bag of a tree-decomposition, minimized over… (More)
This paper studies compact routing schemes for networks with low doubling dimension. Two variants are explored, name-independent routing and labeled routing. The key results obtained for this model… (More)
We consider small world graphs as defined by Kleinberg (2000), i.e., graphs obtained from a <i>d</i>-dimensional mesh by adding links chosen at random according to the <i>d</i>-harmonic distribution.… (More)
with group communication primitives. The proceedings of the conference were published by Springer in LNCS number 1914. They were edited by Maurice Herlihy who also chaired the program committee. Most… (More)
We study a novel separator property called <i>k-path separable</i>. Roughly speaking, a <i>k-path separable</i> graph can be recursively separated into smaller components by sequentially removing… (More)
Chronic HCV infection is an independent risk factor for HCC (1–3). The diagnosis of HCC is generally made when a patient with a mass lesion in a cirrhotic liver presents with an -fetoprotoin (AFP)… (More)
Purpose: Gastric intestinal metaplasia (GIM) is a premalignant alteration of normal gastric epithelium. This process is driven predominantly by Helicobacter pylori (HP). The “African enigma” is a… (More)
Introduction: It is common to find malignant infiltration of the liver in hematogenous malignancies such as acute leukemia or lymphoma. Hepatic involvement is usually mild and clinically silent at… (More)
Interferon-a (IFN-a) has been well known to cause both dose-dependent and idiosyncratic toxicities. The dose-dependent side effects, which include flulike symptoms, leukopenia, anemia, and… (More)
Normalization of markedly elevated alpha-fetoprotein in a virologic nonresponder with HCV-related cirrhosis.
Measurement of serum AFP can be useful in the diagnosis of hepatocellular carcinoma (HCC). AFP is a fetal protein that is not normally present in the serum of adults but is elevated in most patients… (More)
Molecular analysis of Cypriot patients with Glutaric aciduria type I: identification of two novel mutations.
OBJECTIVES The purpose of this study was to identify the mutations in the glutaryl-CoA dehydrogenase gene (GCDH) in ten Cypriot patients with Glutaric aciduria type I (GAI). DESIGN AND METHODS… (More)
The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic…
The nonstructural protein 3 (NS3) of Dengue virus (DV) is a multifunctional enzyme carrying activities involved in viral RNA replication and capping: helicase, nucleoside 5'-triphosphatase (NTPase),… (More)
HIV-1 RT Inhibitors with a Novel Mechanism of Action: NNRTIs that Compete with the Nucleotide Substrate
HIV-1 reverse transcriptase (RT) inhibitors currently used in antiretroviral therapy can be divided into two classes: (i) nucleoside analog RT inhibitors (NRTIs), which compete with natural… (More)
A simple and straightforward methodology for the parallel, solution-phase synthesis of novel 4-dialkylamino-2-methylsulfonyl-6-vinylpyrimidines 9a-j has been developed. Starting from… (More)
Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides.
BACKGROUND To gain a molecular understanding of a biochemical process, the crystal structure of enzymes that catalyze the reactions involved is extremely helpful. Often the question arises whether… (More)
Investigation of novel lipid-functionalized PNA monomers as potential HIV-1 non-nucleoside reverse transcriptase and/or integrase inhibitors.
A range of novel N-terminal lipid-functionalized peptide nucleic acid (PNA) monomers have been prepared and their abilities to inhibit HIV-1 reverse transcriptase and integrase have been examined.
Hepatitis C virus (HCV) is the major etiological agent of human non-A and non-B hepatitis, affecting more than 170 million people worldwide. While the current standard of care for the treatment of… (More)
Along with nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) have gained a definitive and important place in… (More)
Property-based Features Given a sentencerepresentation pair, for each property listed in Table 2, we compute if it holds for the representation. For each property that holds and for each n-gram in… (More)
In this paper, we discuss a new decision-support system for scheduling paper manufacturing and distribution. Scheduling production and distribution of paper is an extremely complex task requiring the… (More)
The evolution of the web triggered XML and web services which pave the way for world-wide information integration and service integration. Web 2.0 concepts and technologies further enriched community… (More)
This paper presents the baseline concept for a multi-year system development of a pico-hydroelectric power system in Nepal. Prior work on pico-hydro systems has focused on one or a few of the factors… (More)
This work describes system engineering of an internet-of-things (IoT) connectivity and satellite data transfer for a pico-hydroelectric power generation system. The system is developed for deployment… (More)
In this paper, we present a design research study in Mobile Assisted Language Learning (MALL) that emphasizes learner created content and contextualized meaning making. In learning Chinese idioms,… (More)
UNLABELLED PHENOMENON: Virtual reality simulators are the subject of several recent studies of skills training for robot-assisted surgery. Yet no consensus exists regarding what a core skill set… (More)
The ready-to-hand access of mobile devices creates the potential for practicing the novel approach of ‘seamless learning’, marked by continuity of the learning experience across different contexts.… (More)
There is a medical myth that ureteral stones larger than 5 mm will not pass spontaneously and require urological intervention for removal. Recent findings indicate that medical expulsive therapy can… (More)
Towards integrating task information in skills assessment for dexterous tasks in surgery and simulation
With the increasing popularity of robotic surgery, several studies in the literature have investigated automatically assessing skill measures based on motion and video data captured from these… (More)
Assessment of Robotic Console Skills (ARCS): construct validity of a novel global rating scale for technical skills in robotically assisted surgery
Skill assessment during robotically assisted surgery remains challenging. While the popularity of the Global Evaluative Assessment of Robotics Skills (GEARS) has grown, its lack of discrimination… (More)
This paper describes Real-Time Vision System (RVS2) which shows quite high performance for low-level image processing while it is implemented in one-board type compact size with small power… (More)
Embedded processors for video image recognition require to address both the cost (die size and power) versus real-time performance issue, and also to achieve high flexibility due to the immense… (More)
Embedded processors for video image recognition in most cases not only need to address the conventional cost (die size and power) versus real-time performance issue, but must also maintain high… (More)
This paper describes existing designs and future design trends of in-vehicle vision processors for driver assistance systems. First, requirements of vision processors for driver assistance systems… (More)
This research was undertaken to evaluate the feasibility of granular ferric hydroxide (GFH) for fluoride removal from aqueous solutions. Batch experiments were performed to study the influence of… (More)
Pyrite and other iron sulfides are readily oxidized by dissolved oxygen in aqueous phase, producing acidity and Fe(2+), which causes significant environmental problems. Applications of surface… (More)
This study investigated the environmental effects of two common emerging contaminants, sulfamethazine (SMZ) and sulfamethoxazole (SMX), and their mixture using a green microalga, Scenedesmus… (More)
BACKGROUND Dynamic changes in the modification pattern of histones, such as acetylation, phosphorylation, methylation, and ubiquitination, are thought to provide a code for the correct regulation of… (More)
Cellular metastasis is the most detrimental step in carcinoma disease progression, yet the mechanisms that regulate this process are poorly understood. CXCL12 and its receptor CXCR4 are co-expressed… (More)
Metastatic spread of tumor cells depends upon intravasation of malignant cells from the primary site and extravasation into the distant organs following remodeling of the basement membrane. We have… (More)
WD-repeat proteins are very diverse, yet these are structurally related proteins that participate in a wide range of cellular functions. WDR13, a member of this family, is conserved from fishes to… (More)
Epidemiological studies have indirectly linked compounds of chromium, nickel and arsenic to human carcinogenesis. However, there is no evidence that metal compounds can transform human cells to the… (More)
A mouse gene encoding a novel member of the WD family of proteins is highly conserved and predominantly expressed in the testis (Wdr13).
Wdr13, a novel member of the WD family of proteins and the mouse homolog of WDR13 is localized to the locus XA1.1 and is predominantly expressed in the testis. The expression begins at the early… (More)
Tropomyosin (TM) family of cytoskeletal proteins is implicated in stabilizing actin microfilaments. Many TM isoforms, including tropomyosin-1 (TM1), are down-regulated in transformed cells.… (More)
Amino terminal, but not the carboxy terminal, sequences of tropomyosin-1 are essential for the induction of stress fiber assembly in neoplastic cells.
The presence of aberrant cytoskeleton, arising from the downregulation of key cytoskeletal proteins such as tropomyosins (TMs), is a prominent feature of many malignant cells and is suggested to… (More)
A capillary gas chromatographic (GC) method was developed for the determination of carbofuran residue in aquatic products (Ctenopharyngodon idellus and Penaens vannamei). The sample was extracted with acetonitrile, defatted by hexane, re-extracted by acetoacetate and cleaned up with a Al2O3 column, and then determined by GC. The standard curve was linear in the investigated range of 0.1 - 10.0 mg/L. The correlation coefficients were more than 0.999 5, the recoveries were 78% - 90% with the… CONTINUE READING
Review of the current application of fi ngerprinting allowing detection of food adulteration and fraud in China
Assessment of pretreatments and enzymatic hydrolysis of wheat straw as a sugar source for bioprocess industry - Semantic Scholar
  title={Assessment of pretreatments and enzymatic hydrolysis of wheat straw as a sugar source for bioprocess industry},
Environmental concerns and rising oil prices have led to development of biofuels from crop residue lignocelluloses, among which wheat straw is an important feedstock used in leading commercial bioethanol processes. Lignocellulose is structured in a way that makes direct bioconversion of biomass into sugars by hydrolytic enzymes difficult and unfeasible, requiring a pretreatment step. Common biomass pretreatment technologies are assessed for potential application in obtaining fermentable sugars… CONTINUE READING
Enhanced biomethane potential from wheat straw by low temperature alkaline calcium hydroxide pre-treatment.
Direct mechanical energy measures of hammer mill comminution of switchgrass , wheat straw , and corn stover and analysis of their particle size distributions
Oral praziquantel (PZQ) preparations have recently been investigated for the treatment of monogeneans that infect the skin and gills of kingfish Seriola lalandi cultured in sea-cages. To evaluate an oral PZQ dosing strategy, the pharmacokinetics of a dissolved and in feed oral PZQ preparation (40 mg kg(-1) body weight) were compared with an intravenous bolus in kingfish plasma and skin using HPLC. Compared with intravenous administration, PZQ bioavailability (area under curve, AUC0-24h) was… CONTINUE READING
A comparison of the palatability of racemic praziquantel and its two enantioseparated isomers in yellowtail kingfish Seriola lalandi
Comparison of praziquantel pharmacokinetics and tissue distribution in fresh and brackish water cultured grass carp (ctenopharyngodon idellus) after oral administration of single bolus
Depletion of praziquantel in plasma and muscle tissue of cultured rockfish Sebastes schlegeli after oral and bath treatment.
The aim of this study was to identify markers specific for granulo-monocytic commitment of progenitor cells. Large panels of antibodies were screened for selective staining of subsets of CD34+ cells from fetal and adult bone marrow. Flow cytometric analysis showed that CD64/fc gamma RI was undetectable on noncommitted progenitor cells (CD34++, CD38-/lo, HLA-DR+) and expressed on a subset of lineage-committed progenitors (CD34+, CD38+) with higher mean orthogonal light scatter than the remaining… CONTINUE READING
Control of human hematopoietic stem/progenitor cell migration by the extracellular matrix protein Slit3
Consistent quantitative gene product expression: #2. Antigen intensities on bone marrow cells are invariant between individuals
Neutrophil phenotypic characteristics in children with congenital asplenia and splenectomized for hereditary spherocytosis.
Defective organization of actin in cultured skin fibroblasts from patients with inherited adenocarcinoma. - Semantic Scholar
Defective organization of actin in cultured skin fibroblasts from patients with inherited adenocarcinoma.
  title={Defective organization of actin in cultured skin fibroblasts from patients with inherited adenocarcinoma.},
In the cytoplasm of well-spread cultured normal fibroblasts, actin is organized into a network of cables that run the length of the cell just inside the adherent cell membrane. A diffuse matrix replaces the cables in fibroblasts that have become tumorigenic as a result of oncogenic transformation. We have found a similar disruption in actin organization in cultured skin fibroblasts (passage 6-10) obtained by biopsy from patients with the inherited colonic cancer, adenomatosis of the colon and… CONTINUE READING
Germline cytoskeletal and extra-cellular matrix-related single nucleotide variations associated with distinct cancer survival rates.
Biological Mechanisms Underlying Structural Changes Induced by Colorectal Field Carcinogenesis Measured with Low-Coherence Enhanced Backscattering (LEBS) Spectroscopy
Quantification of nanoscale density fluctuations by electron microscopy: probing cellular alterations in early carcinogenesis.
Architecture for integrated test data compression and abort-on-fail testing in a multi-site environment
Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes. - Semantic Scholar
Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes.
  title={Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes.},
The TNF-like cytokine TL1A augments IFN-gamma production by anti-CD3 plus anti-CD28 and IL-12/IL-18-stimulated peripheral blood (PB) T cells. However, only a small subset of PB T cells respond to TL1A stimulation with IFN-gamma production. PB CCR9+ T cells represent a small subset of circulating T cells with mucosal T cell characteristics and a Th1/Tr1 cytokine profile. In the current study, we show that TL1A enhanced IFN-gamma production by TCR- or CD2/CD28-stimulated CCR9(+)CD4+ PB T cells… CONTINUE READING
Circulating levels of TNF-like cytokine 1A correlate with reflected waves and atherosclerosis extent and may predict cardiac death in patients with stable coronary artery disease.
Treatment with agonistic DR 3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease
The "phiKMV-like viruses" comprise an important genus of T7 related phages infecting Pseudomonas aeruginosa. The genomes of these bacteriophages have localized single-strand interruptions (nicks), a distinguishing genomic trait previously thought to be unique for T5 related coliphages. Analysis of this feature in the newly sequenced phage phikF77 shows all four nicks to be localized on the non-coding DNA strand. They are present with high frequencies within the phage population and are… CONTINUE READING
A Suggested New Bacteriophage Genus, “Kp34likevirus”, within the Autographivirinae Subfamily of Podoviridae
Selection of phages and conditions for the safe phage therapy against Pseudomonas aeruginosa infections
Methodologies to assess muscle co-contraction during gait in people with neurological impairment - a systematic literature review. - Semantic Scholar
Methodologies to assess muscle co-contraction during gait in people with neurological impairment - a systematic literature review.
  title={Methodologies to assess muscle co-contraction during gait in people with neurological impairment - a systematic literature review.},
PURPOSE To review the methodologies used to assess muscle co-contraction (MCo) with surface electromyography (sEMG) during gait in people with neurological impairment. METHODS The Scopus (1995-2013), Web of Science (1970-2013), PubMed (1948-2013) and B-on (1999-2013) databases were searched. Articles were included when sEMG was used to assess MCo during gait in people with impairment due to central nervous system disorders (CNS). RESULTS Nineteen articles met the inclusion criteria and most… CONTINUE READING
Ankle muscle coactivation and its relationship with ankle joint kinematics and kinetics during gait in hemiplegic patients after stroke.
Ankle muscle coactivation during gait is decreased immediately after anterior weight shift practice in adults after stroke.
Does muscle coactivation influence joint excursions during gait in children with and without hemiplegic cerebral palsy? Relationship between muscle coactivation and joint kinematics.