The Brown County Sheriff's Office is looking for a woman considered missing and endangered last seen on October 10.
HOWARD, Wis. - The Brown County Sheriff's Office is looking for a woman considered missing and endangered last seen on October 10.
Azure Ra Dunbar, 24, was last seen at a residence in Howard with a man named "Jay." Before leaving the residence, they were seen arguing inside a car Saturday.
Dunbar has not been seen since and her whereabouts are unknown. Her family reported her missing Tuesday night.
The two were driving a 2008 black Mazda 3 hatchback bearing Wisconsin registration 153-UYK, which has been entered as stolen.
Ross Mirkarimi joked about HBO or another channel creating a reality television show about San Francisco's political theater.
The City's Budget and Finance Committee supported a measure Tuesday that would expand rebates for documentaries and reality shows filmed in San Francisco.
The proposal could go before the full board of supervisors next week for final approval. After Tuesday's stamp of approval, Supervisor Ross Mirkarimi joked about one of the potential beneficiaries of the new program.
"To our reality film enthusiasts, I think you have a prospect by considering a reality TV show of the Board of Supervisors of San Francisco," he said. "I’m surprised nobody’s picked up on that yet — or at least maybe an HBO documentary of some kind."
If passed the program would offer rebates to production companies of up to $600,000 for producing documentaries and reality shows in the City.
Gov. Rick Scott was in Hialeah Friday campaigning for the Florida senate seat and reaching out to the South Florida Cuban community, discussing his plan to promote freedom and democracy in Cuba.
"The Cuban exile community in South Florida is an example what is possible if the Cuban people are free to forge a future if liberty and prosperity for their families," Scott told the crowd at the Goodlet Theater, backed by a group of Cuban exiles.
Scott listed his agenda to the predominantly Cuban audience, saying the senate seat will give him a better platform to achieve his agenda.
"No agent of the Cuban government should be granted any type of visa to the United States under the cover of culture academic exchange. We must reinstate the Cuban government to the list of state sponsors of terrorism," he said. "As the governor of Florida I've had this opportunity to do this. But as a senator I’ll probably have a bigger role as a senator to push this. And I’m going to do it."
Ray Anthony, a 22-year-old third generation Cuban from West Miami, came to support Scott who is running against incumbent Sen. Bill Nelson in the November midterm election.
"I think it's so admirable of Gov. Scott who is not of our background shares that deep passion for freedom for democracy," Anthony said. "Sen. Bill Nelson has done nothing for our community. He’s been there for God knows how many years."
Elizabeth Guzman and Hala Ayala, the first two Latinas ever elected to Virginia's House of Delegates. Elizabeth Guzman, Hala Ayala campaigns
Two Latinas, Elizabeth Guzmán and Hala Ayala made history in Virginia; they are the first Hispanic women elected to the state's House of Delegates.
The two women not only beat long-term incumbents, but flipped their districts from Republican to Democrat. Ayala’s opponent, Richard Anderson, ran unopposed in 2015, but while the Democrats did not even run a candidate against Anderson in the 51st District, Ayala beat Anderson by almost 6 percentage points and mobilized 14,000 voters to win. Similarly, Guzmán was able to increase turnout in Prince William by 72 percent and was able to win by a comfortable nine point margin.
Guzmán, who is Peruvian-American, is a public administrator with a background in social work whose platform includes expanded preschool and family and health services, including mental health, and more accessibilty to these services in local schools.
Ayala is a cybersecurity specialist who helped organize the historic Women's March — she was a local president for the National Organization for Women — and quit her job to run for office in the county where she grew up. She told a reporter during her campaign that she believed President Donald Trump and his administration would "discriminate against people who look like me." During the campaign, she spoke of how she had been on Medicaid several years ago to obtain the health insurance that saved one of her two sons, and vowed to fight for these programs.
The victories were part of a Democratic sweep in the state that energized the party after worries that Virginia's Democratic gubernatorial candidate, Ralph Northam, would lose to Republican candidate Ed Gillespie.
Gillespie's use of ads featuring MS-13 gang crime to attack Northam on his stances on immigration angered Latino groups.
Following the Democratic victory Tuesday night, CASA in Action, the political arm of an immigrant rights organization based in neighboring Maryland, said in a statement that their extensive grassroots organization had paid off; nine of the ninde candidates they endorsed won.
In a press release with the heading, "Immigrants Turned Hate into Political Power," CASA in Action touted their efforts, stating they knocked "on over 58,000 doors and reached over 20,000 voters via text and phone calls." The group also mounted an aggressive communications stategy with TV and radio ads in the top eight Latino radio stations and a bilingual digital program.
"If we want greater voter participation, we must connect with people meaningfully and positively," said CASA in Action president Gustavo Torres.
In a conference call with media on Wednesday, progressive organizers from CASA in Action and NextGen America, as well as polling analyst Matt Barreto of Latino Decisions, described last night's wins in Virginia as a repudiation of racial politics that associated immigrants and minorities with negative messages.
“The Virginia campaign sends a very clear message that building your campaign around anti-immigrant, anti-Latino, anti-black messages does not work," said Barreto, a professor at UCLA. "We saw this before with Sharron Angle in Nevada and Tom Tancredo in Colorado, who failed miserably in their anti-immigrant crusade.”
Also of note in last night’s victory was the success of Ayala and Guzmán against two non-Latino white men who had repeatedly won in their districts by wide margins, or had run unopposed. Research has shown that gender can act as a mitigating factor in elections where Hispanic women can achieve greater success than their male counterparts.
Kansas University political scientist Christina Bejarano, author of the book "The Latina Advantage," said in an email that Ayala and Guzmán’s “gender and ethnic identities likely provided for an increased pool of supporters, which is even more apparent in our currently charged political environment that is leaving most diverse groups on edge.”
Bejarano urged Democrats to take this as a lesson in how to overcome narrow perspectives regarding which voters to appeal to instead of expanding the reach of the party’s message.
“The election of Guzmán and Ayala demonstrate that Latinas are strong political candidates that can run successful grassroots campaigns in non-traditional districts," Bejarano said. "As a result of these successes, we will likely see more Latinas running for office and hopefully they will get increased campaign support if the political parties and organizations learn from this lesson.”
Guzmán and Ayala join a list of notable victories by women and people of color. Sheila Oliver will be the first black woman to be lieutenant governor of New Jersey. Justin Fairfax also won lieutenant governor in Virginia, making him the first African American to win a statewide office in almost 30 years.
Also in Virginia, Danica Roem is an openly trans woman who won election, defeating a conservative incumbent who had not only been in office for over 20 years, but had sponsored an anti-trans “bathroom bill” regulating where transgender persons could use the restroom and refused to debate Roem or refer to her as "she."
Ravhinder Bhalla became the first Sikh mayor of Hoboken, New Jersey, despite incendiary flyers calling for Bhalla to be deported and other ones about terrorism. Kathy Tran, a Vietnamese refugee, became the first Asian American woman elected to the Virginia House of Delegates and Vin Gopal became the first Indian-American to win a legislative seat, defeating long time incumbent Jennifer Beck in Monmouth County, New Jersey. Gopal’s win also flipped his district from Republican to Democrat.
Tuesday's elections reflect a two-tiered approach on the issue of minority outreach and "identity politics." Where statewide candidates like Virginia's Ralph Northam were more careful in their direct appeal to minorities, the Democratic Party ran a diverse group of candidates down ticket that focused on bread-and-butter issues like healthcare. Roem focused her campaign on traffic issues in her community.
Other Latinos who won in local and state elections on Tuesday include Democrat Alfonso López, who won a fourth term to the Virginia House of Delegates. In Massachusetts, Andy Vargas, 24, defeated a longtime incumbent for a seat in the state's House of Representatives. Vargas made history in 2015 when he became the youngest city council member elected in his hometown of Haverhill. In Atlanta, Latino attorney Jason Esteves won his current seat on the Atlanta Board of Education.
CLEVELAND (AP) Cavaliers center Anderson Varejao had surgery to repair a split leg muscle, an injury that could sideline him two more months.
Varejao had the operation on Thursday at The Cleveland Clinic. The team said he is resting comfortably and will be kept overnight. Varejao, the NBA's leading rebounder, has been sidelined since getting hurt against Toronto on Dec. 18. His injury was initially believed to be just a bad bruise, but further testing revealed that the quadriceps muscle tore near his right knee.
He is expected to miss at least six weeks. Varejao, one of the league's hardest working and hustling players, has missed more than 100 games over the past three seasons with injuries.
EL PASO, Texas -- The first black basketball player at what would become UTEP and the first at a major university in the former Southern Confederacy has died.
Brown led the Miners of what was then Texas Western College to Border Conference titles in 1957 and '59 and was the conference's 1957 Most Valuable Player.
The National Concierge Association (NCA) Invites You To Attend It’s 18th Annual Educational Conference August 4th-6th Chicago, IL Please register and pay online today! Plus, all the details: Click Here See attached Conference Agenda and Registration Documents below. 2016-Conf-registration-docs 2016-Conf-Agenda.2.0
Chicago Mayor makes note about the value of Concierges to their tourism and welcomes attendees at the August NCA Conference. Read more about it in attached letter from Mayor Rahm Emmanuel! Click link: Greetings National Concierge Association 2016
Agents capable of preventing the misfolding and sequestration of the microtubule-stabilizing protein tau into insoluble fibrillar aggregates hold considerable promise for the prevention and/or treatment of neurodegenerative tauopathies such as Alzheimer's disease. Because tauopathies are characterized by amyloidosis that is restricted to the central nervous system (CNS), plausible candidate compounds for in vivo evaluation must both prevent tau fibrillization and achieve significant brain levels. Recently, we reported the discovery of the aminothienopyridazine (ATPZ) class of tau aggregation inhibitors and now describe a series of new analogues that are both effective inhibitors of tau fibrillization and display significant brain-to-plasma exposure ratios after administration to mice. Further, two of the most promising examples, 15 and 16, were found to reach significant brain exposure levels following oral administration. Taken together, these results suggest that examples from the ATPZ class hold promise as candidates for in vivo efficacy studies in animal models of neurodegenerative tauopathies.
In recent years, several compound classes have been disclosed that can effectively inhibit the assembly of tau into filaments in vitro.– However, with the exception of a member of the phenothiazines, methylene blue (1, ), which has progressed to human clinical trials, no tau assembly inhibitor has been assessed for efficacy in vivo. Notably, the results from a Phase 2 study, involving 321 patients with mild or moderate AD, revealed a significant reduction in cognitive decline in patients that received methylene blue compared to a placebo. These promising findings, if confirmed, validate the idea that tau aggregation inhibitors can be therapeutically useful for the treatment of neurodegenerative tauopathies. However, since methylene blue is known to modulate a multitude of biological targets, whether the outcome observed in the Phase 2 study can be ascribable solely to a direct inhibition of tau aggregation is not yet clear. As a result, further evaluation of the therapeutic potential of tau aggregation inhibitors is likely to require in vivo efficacy studies involving additional candidate compounds. To this end and in light of the fact that tauopathies are characterized by amyloidosis that is restricted to the central nervous system (CNS), candidate compounds for in vivo testing will have to be brain-penetrant. Although numerous classes of tau fibrillization inhibitors have been reported in recent years, including some which exhibit calculated physical-chemical properties potentially appropriate for blood-brain barrier (BBB) permeation, to date there are no reports demonstrating brain penetration of any of these candidates.
(A) Representative dose-response curves in the heparin-induced K18PL fibrillization assay; (B) SDS-PAGE analysis of supernatant (S) or pellet (P) samples obtained after centrifugation of fibrillizing mixtures incubated in the presence of DMSO vehicle, or 100 μM of test compound (11 and 16).
(A) Comparison of maximal percent inhibition of K18PL fibrillization caused by test compounds in which the fibrillizing mixtures did (sup) or did not (tot) undergo centrifugation at time zero to remove insoluble material. Compounds were added at 50 μM to the tau fibrillization mixture and incubated for 30 min. Samples were then divided in two halves, one of which was incubated without further treatment (“tot”), and one that was centrifuged at 186,000g for 30 min. After centrifugation of the latter sample, the supernatants (“sup”) was collected and incubated as per the fibrillization protocol. (B) Representative examples of SDS-PAGE analysis of supernatant (S) or pellet (P) samples obtained after centrifugation of fibrillizing mixtures prior to incubation; (C) Representative dose-response curves with (“sup”) and without (“tot”) initial centrifugation.
MT-assembly assay. Tubulin (30 μM) and tau40 (20 μM) were incubated with the test compound (50 μM; e.g., 16 [green triangles]) or DMSO (open and black squares) to evaluate possible interference in the tau-promoted MT-polymerization that may be caused by the ATPZ inhibitors of tau aggregation. As control experiment, MT-polymerization assay was also conducted in the absence of tau40 (open blue circles). Additional results are presented in the .
(A) Brain and plasma level of 16 after i.v. administration of 2 mg/Kg; (B) Brain and plasma level of 16 after oral (p.o.) administration of 5 mg/Kg; (C) Brain and plasma level of 15 after oral administration of 5 mg/Kg.
The aim of this study was to examine the effect of chlorhexidine disinfection, as a chemical method of oral hygiene practice, and subsequent use of probiotics on halitosis in children. The effects of mechanical and chemical oral hygiene practice methods on the severity of halitosis were also assessed.
208 children with organoleptic test (OLT) scores of 2 or more were randomly assigned to four groups: A: conventional oral hygiene practices (COH) including toothbrushing and flossing; B: COH + tongue scraping (TS); C: COH + TS + chlorhexidine; D: COH + TS + chlorhexidine + probiotics. OLT was performed at 1-week and 3-month follow-ups.
A significant and stable number of participants showed major and moderate levels of improvement in OLT scores in group D (p < 0.001). The improvement of OLT scores in group C was also significant (p < 0.001), but not stable over the follow-ups (p = 0.44). Neither significant nor stable improvements in the OLT scores were detected in groups A and B through follow-ups (p > 0.05).
Probiotic therapy following oral disinfection with chlorhexidine may reduce the severity of halitosis over longer periods.
Review The mitochondrial respiratory chain of yeast. Structure and biosynthesis and the role in cellular metabolism.
As a distributor, your sales force is responsible for driving sales and building customer rapport. But, are they fully equipped to do so? With a varied product assortment and multiple customers to visit, they often become order takers instead of trusted advisors. NCR’s Power Sell can help. Sales reps can now analyze purchases, suggest new items, and increase profitability for each order – which ultimately grows both your customers’ business and your own.
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