I don’t mean to keep you guys up at night, but this crunt would be president if something should happen to Trump and Pence.
Don’t they have to still vote for her to be speaker, or is this just a default thing for the old hag?
And if the newly elected young Dem socialists like Ocasio-Cortez don’t go along with with electing Pelosi speaker again which radical will it be?!
This is true, but then again this would be a valid case to pursue the 25th amendment after all, she’s certifiably insane.
Damn James Woods. Picture him as Press Secretary. Any White House word mincing machine would self-destruct and Liberal’s heads would explode world-wide.
The Democrat Party runs on lies, innuendo and filthy lucre, Nancy controls the hoppers for all three.
@old_oaks – [EDIT: Oops. I misread your comment. Yes, Pelosi has to be elected by the Dems to becomd Speaker. There may be some in-fighting there, though. Here’s the rest of the line of succession for anyone interested.]
The Constitution says that if the president is unable for whatever reason, then the VP becomes president. Succession after that is up to Congress. The Presidential Succession Act of 1947 (plus subsequent amendments) lists this line of succession after the VP:
Pure speculation that I hope never comes true, but a Pelosi presidency would be simultaneously hilarious and terrifying. I am thinking along the lines of the “Final Destination” horror series, only starring Steve Carrell, Jim Carrey and Zack Garifalakis as the Three Stooges trying to outdo each other with wacky antics in the midst of death and terror.
It would be difficult to envision anyone less qualified to be President than Pelosi. The only bright spot would be the likely death of the Democrat party if she didn’t manage to destroy the United States in the process.
With Trump’s backing Pelosi will become speaker of the house BECAUSE of her senility which will become apparent to all. I can just see 2020 campaign ads featuring her with the slogan “This is your mind on liberalism”.
Trump is smart enough to know that she realizes that some cooperation with him will be necessary if they have any hope of keeping the house.
They have the house but they are still hobbled and won’t get much done without the president. If all they want to do is hold hearings they’ll have a short stay.
Can someone with the right connections convince her and RBG to go ice skating together in the near future?
Pharmacologic evidence for 5-HT1A receptors associated with human retinal pigment epithelial cells in culture. | IOVS | ARVO Journals
Pharmacologic evidence for 5-HT1A receptors associated with human retinal pigment epithelial cells in culture.
PURPOSE: The authors investigate the possible presence of 5-hydroxytryptamine (5-HT1) type serotonin receptors negatively coupled to adenylate cyclase activity in cultured human retinal pigment epithelial (RPE) cells. METHODS: Adenylate cyclase activity was assessed by the determination of cellular adenosine 3':5' cyclic monophosphate (cAMP) levels and the effects of serotonin on both basal and forskolin-stimulated cAMP levels studied. RESULTS: Serotonin at 100 microM had no effect on the basal levels of cAMP in cultured human RPE cells, but attenuated by 43.6% the stimulation in cAMP production induced by forskolin (5 microM). This effect was dose dependent for serotonin with half-maximal inhibition (EC50) occurring at approximately 1.5 x 10(-9) M. The 5-HT1 receptor agonist 8-hydroxy [2-di-n-propylamino] tetralin (8-OH DPAT), buspirone, 5-carboxyamidotryptamine, and RU24969 mimicked the inhibitory effect of serotonin in a dose-dependent manner. The actions of serotonin and 8-OH DPAT (10 microM) were dose-dependently attenuated by the serotonergic antagonists spiroxatrine, propranolol, and spiperone. Pretreatment of RPE cell cultures with pertussis toxin abolished the serotonin-induced reduction of forskolin-elevated cAMP levels. Stimulation of cAMP production by the beta-adrenoceptor agonist isoproterenol at 0.1 microM, but not at 10 microM or 100 microM, also was attenuated by serotonin (100 microM), whereas cAMP production induced by the adenosine receptor agonist 5'-[N-ethyl]-carboxamidoadenosine (NECA) at 1 microM, 10 microM, and 100 microM was unaffected. Serotonin and 8-OH DPAT dose-dependently inhibited isoproterenol-stimulated (0.1 microM) cAMP production with EC50 values of approximately 10 microM, and pertussis toxin pretreatment partially blocked these effects. CONCLUSIONS: Cultured human RPE cells possess 5-HT1A receptors negatively coupled to cAMP production through a pertussis toxin-sensitive G protein. These receptors show differential effects on forskolin-, isoproterenol-, and NECA-stimulated cAMP production, which may reflect a unique spatial distribution of receptor proteins or the phenotypic heterogeneity of RPE cells that is the result of or that is preserved in culture.
Abstract: : Purpose:FDT has not been extensively evaluated in non-glaucomatous optic neuropathies such as NAION. FDT may demonstrate more extensive damage in NAION as in glaucomatous optic neuropathy, or conversely, the frequent altitudinal defects in NAION may limit its usefulness due to increased ocular scatter across the horizontal raphe as has been demonstrated with hemianopias across the vertical midline. This study will determine if visual functional abnormalities in altitudinal NAION are more extensive with FDT than with SITA standard perimetry. Methods:20 eyes of 14 patients diagnosed with NAION with altitudinal defects on SITA were examined using FDT. The percentage of abnormal test locations (points outside the 95% confidence interval on total deviation plot) for the involved and uninvolved hemifield were calculated for each technique. To ensure differences in scotoma area between FDT and SITA were not a consequence of patients with small disc area, 20 eyes of 10 normal subjects matched for disc area and age were also tested. Results:Global parameters between FDT and SITA were highly correlated (MD, rho= 0.78, p&lt;0.001, PSD, rho=0.77, p&lt;0.001) Average defect size (% of abnormal test locations) was similar in the hemifield containing the altitudinal defect (SITA=93.3%, FDT=93.9%), but in the contra-lateral hemifield, FDT revealed more extensive loss than seen with SITA (SITA=9.2%, FDT=42.2%) Controls demonstrated minimal abnormalities on either task (SITA=0.02%, FDT=0.02%). The altitudinal nature of field loss was evident in 18 of 20 eyes. Conclusion:FDT demonstrates more extensive defects in some patients with NAION with abnormalities extending into the hemifield that was relatively intact using SITA, indicating that damage in altitudinal NAION may be more diffuse than has been estimated by conventional techniques.
Abstract: : Purpose:To establish normal ranges of thickness of various retinal regions in healthy subjects with different degrees of ametropia when using Optical Coherence Tomography (OCT). Methods:Thirty-six healthy normal subjects, ages 20 to 83 years (48 18 years) were recruited. All subjects had a complete ophthalmologic exam. Their refractive error (spherical equivalent) varied from -14 to + 4 diopters. The ocular axial length was measured with A-scan ultrasonography. The axial length of the eyes ranged from 21.7 to 26.4 mm. OCT was used to measure the retinal thickness in 3 locations of one eye in each subject: macula (including fovea), peripapillary retina, and retina 6 mm temporal to the fovea. Results:Average retinal thickness by OCT in emmetropic eyes was 256, 233 and 201 um for peripapillary retina, macula and temporal retina, respectively. Average thickness in hyperopic eyes was 262, 227 and 182 um for peripapillary retina, macula and temporal retina, respectively. Average thickness in myopic eyes was 246, 224 and 181 um for peripapillary retina, macula and temporal retina, respectively. The thickness in the peripapillary, macular or temporal retina was not significantly correlated with the axial length or refractive power of the eye. A lack of statistically significant difference between the average thicknesses in the hyperopic, emmetropic, and myopic eyes was found. Conclusion:The average thickness by OCT measurement in the peripapillary retina, macula and posterior temporal retina was not influenced by either axial length or refractive status of the eye.