Giải Primetime Emmy cho nữ diễn viên chính trong series ngắn hoặc phim truyền hình xuất sắc nhất
Người đoạt giải > 2000s

| Năm | Diễn viên | Chương trình truyền hình | Vai diễn | Kênh |
| --- | --- | --- | --- | --- |
1999-2000 (52nd): 
| 1999-2000 (52nd) | Halle Berry | Introducing Dorothy Dandridge | Dorothy Dandridge | HBO |
| 1999-2000 (52nd) | Judy Davis | A Cooler Climate | Paula Tanner | Showtime |
| 1999-2000 (52nd) | Sally Field | A Cooler Climate | Iris Prue | Showtime |
| 1999-2000 (52nd) | Holly Hunter | Harlan County War | Ruby Kincaid | Showtime |
| 1999-2000 (52nd) | Gena Rowlands | The Color of Love: Jacey's Story | Georgia Porter | CBS |
2000-2001 (53rd): 
| 2000-2001 (53rd) | Judy Davis | Life with Judy Garland: Me and My Shadows | Judy Garland | ABC |
| 2000-2001 (53rd) | Judi Dench | The Last of the Blonde Bombshells | Elizabeth | HBO |
| 2000-2001 (53rd) | Holly Hunter | When Billie Beat Bobby | Billie Jean King | ABC |
| 2000-2001 (53rd) | Hannah Taylor-Gordon | Anne Frank: The Whole Story | Anne Frank | ABC |
| 2000-2001 (53rd) | Emma Thompson | Wit | Vivian Bearing | HBO |
2001-2002 (54th): 
| 2001-2002 (54th) | Laura Linney | Wild Iris | Iris Bravard | Showtime |
| 2001-2002 (54th) | Angela Bassett | The Rosa Parks Story | Rosa Parks | CBS |
| 2001-2002 (54th) | Blythe Danner | We Were the Mulvaneys | Corinne Mulvaney | Lifetime |
| 2001-2002 (54th) | Vanessa Redgrave | The Gathering Storm | Clementine Churchill | HBO |
| 2001-2002 (54th) | Gena Rowlands | Wild Iris | Minnie Brinn | Showtime |
2002-2003 (55th): 
| 2002-2003 (55th) | Maggie Smith | My House in Umbria | Emily Delahunty | HBO |
| 2002-2003 (55th) | Thora Birch | Homeless to Harvard: The Liz Murray Story | Liz Murray | Lifetime |
| 2002-2003 (55th) | Helena Bonham Carter | Live from Baghdad | Ingrid Formanek | HBO |
| 2002-2003 (55th) | Jessica Lange | Normal | Irma Applewood | HBO |
| 2002-2003 (55th) | Helen Mirren | The Roman Spring of Mrs. Stone | Karen Stone | Showtime |
2003-2004 (56th): 
| 2003-2004 (56th) | Meryl Streep | Angels in America | Hannah Pitt / Ethel Rosenberg / The Rabbi / The Angel Australia | HBO |
| 2003-2004 (56th) | Glenn Close | The Lion in Winter | Queen Eleanor of Aquitaine | Showtime |
| 2003-2004 (56th) | Judy Davis | The Reagans | Nancy Reagan | Showtime |
| 2003-2004 (56th) | Helen Mirren | Prime Suspect 6: The Last Witness | Jane Tennison | PBS |
| 2003-2004 (56th) | Emma Thompson | Angels in America | Nurse Emily / Homeless Woman / The Angel America | HBO |
2004-2005 (57th): 
| 2004-2005 (57th) | S. Epatha Merkerson | Lackawanna Blues | Rachel "Nanny" Crosby | HBO |
| 2004-2005 (57th) | Halle Berry | Their Eyes Were Watching God | Janie Crawford | ABC |
| 2004-2005 (57th) | Blythe Danner | Back When We Were Grownups | Rebecca | CBS |
| 2004-2005 (57th) | Cynthia Nixon | Warm Springs | Eleanor Roosevelt | HBO |
| 2004-2005 (57th) | Debra Winger | Dawn Anna | Dawn Anna | Lifetime |
2005-2006 (58th): 
| 2005-2006 (58th) | Helen Mirren | Elizabeth I | Queen Elizabeth I | HBO |
| 2005-2006 (58th) | Gillian Anderson | Bleak House | Lady Dedlock | PBS |
| 2005-2006 (58th) | Kathy Bates | Ambulance Girl | Jane Stern | Lifetime |
| 2005-2006 (58th) | Annette Bening | Mrs. Harris | Jean Harris | HBO |
| 2005-2006 (58th) | Judy Davis | A Little Thing Called Murder | Sante Kimes | Lifetime |
2006-2007 (59th): 
| 2006-2007 (59th) | Helen Mirren | Prime Suspect: The Final Act | Jane Tennison | PBS |
| 2006-2007 (59th) | Queen Latifah | Life Support | Ana | HBO |
| 2006-2007 (59th) | Debra Messing | The Starter Wife | Molly Kagan | USA |
| 2006-2007 (59th) | Mary-Louise Parker | The Robber Bride | Zenia Arden | Oxygen |
| 2006-2007 (59th) | Gena Rowlands | What If God Were the Sun? | Melissa Eisenbloom | Lifetime |
2007-2008 (60th): 
| 2007-2008 (60th) | Laura Linney | John Adams | Abigail Adams | HBO |
| 2007-2008 (60th) | Judi Dench | Cranford | Miss Matty Jenkyns | PBS |
| 2007-2008 (60th) | Catherine Keener | An American Crime | Gertrude Baniszewski | Showtime |
| 2007-2008 (60th) | Phylicia Rashād | A Raisin in the Sun | Lena Younger | ABC |
| 2007-2008 (60th) | Susan Sarandon | Bernard and Doris | Doris Duke | HBO |
2008-2009 (61st): 
| 2008-2009 (61st) | Jessica Lange | Grey Gardens | Edith "Big Edie" Beale | HBO |
| 2008-2009 (61st) | Drew Barrymore | Grey Gardens | Edith "Little Edie" Beale | HBO |
| 2008-2009 (61st) | Shirley MacLaine | Coco Chanel | Coco Chanel | Lifetime |
| 2008-2009 (61st) | Sigourney Weaver | Prayers for Bobby | Mary Griffith | Lifetime |
| 2008-2009 (61st) | Chandra Wilson | Accidental Friendship | Yvonne Caldwell | Hallmark Channel |