Giải Mâm xôi vàng cho diễn viên nữ chính tồi nhất
Chiến thắng và được đề cử > Thập niên 2000s

| Năm | Diễn viên | Phim | Vai diễn |
| --- | --- | --- | --- |
| 2000 (21st) | Madonna | The Next Best Thing | Abbie Reynolds |
| 2000 (21st) | Kim Basinger | Bless the Child | Maggie O'Connor |
| 2000 (21st) | Kim Basinger | I Dreamed of Africa | Kuki Gallmann |
| 2000 (21st) | Melanie Griffith | Cecil B. DeMented | Honey Whitlock |
| 2000 (21st) | Bette Midler | Isn't She Great | Jacqueline Susann |
| 2000 (21st) | Demi Moore | Passion of Mind | Martha Marie / 'Marty' Talridge |
| 2001 (22nd) | Mariah Carey | Glitter | Billie Frank |
| 2001 (22nd) | Penélope Cruz | Blow | Mirtha Jung |
| 2001 (22nd) | Penélope Cruz | Captain Corelli's Mandolin | Pelagia |
| 2001 (22nd) | Penélope Cruz | Vanilla Sky | Sofia Serrano |
| 2001 (22nd) | Angelina Jolie | Lara Croft: Tomb Raider | Lara Croft |
| 2001 (22nd) | Angelina Jolie | Original Sin | Julia Russell / Bonny Castle |
| 2001 (22nd) | Jennifer Lopez | Angel Eyes | Sharon Pogue |
| 2001 (22nd) | Jennifer Lopez | The Wedding Planner | Mary Fiore |
| 2001 (22nd) | Charlize Theron | Sweet November | Sara Deever |
| 2002 (23rd) | Madonna (tie) | Swept Away | Amber Leighton |
2002 (23rd): 
| 2002 (23rd) | Britney Spears (tie) | Crossroads | Lucy Wagner |
| 2002 (23rd) | Angelina Jolie | Life or Something Like It | Lanie Kerrigan |
| 2002 (23rd) | Jennifer Lopez | Enough | Slim Hiller |
| 2002 (23rd) | Jennifer Lopez | Maid in Manhattan | Marisa Ventura |
| Winona Ryder | Mr. Deeds | Babe Bennett |  |
| 2003 (24th) | Jennifer Lopez | Gigli | Ricki |
| 2003 (24th) | Drew Barrymore | Charlie's Angels: Full Throttle | Dylan Sanders |
| 2003 (24th) | Drew Barrymore | Duplex | Nancy Kendricks |
| 2003 (24th) | Kelly Clarkson | From Justin to Kelly | Kelly Taylor |
| 2003 (24th) | Cameron Diaz | Charlie's Angels: Full Throttle | Natalie Cook |
| 2003 (24th) | Angelina Jolie | Beyond Borders | Sarah Jordan |
| 2003 (24th) | Angelina Jolie | Lara Croft: Tomb Raider – The Cradle of Life | Lara Croft |
| 2004 (25th) | Halle Berry | Catwoman | Patience Phillips / Catwoman |
| 2004 (25th) | Hilary Duff | A Cinderella Story | Sam Montgomery |
| 2004 (25th) | Hilary Duff | Raise Your Voice | Terri Fletcher |
| 2004 (25th) | Angelina Jolie | Alexander | Queen Olympias |
| 2004 (25th) | Angelina Jolie | Taking Lives | Illeana Scott |
| 2004 (25th) | Mary-Kate and Ashley Olsen | New York Minute | Roxy and Jane Ryan |
| 2004 (25th) | Shawn & Marlon Wayans (the Wayans "sisters") | White Chicks | "Brittany and Tiffany Wilson" |
| 2005 (26th) | Jenny McCarthy | Dirty Love | Rebecca Sommers |
| 2005 (26th) | Jessica Alba | Fantastic Four | Sue Storm / Invisible Woman |
| 2005 (26th) | Jessica Alba | Into the Blue | Sam |
| 2005 (26th) | Hilary Duff | Cheaper by the Dozen 2 | Lorraine Baker |
| 2005 (26th) | Hilary Duff | The Perfect Man | Holly Hamilton |
| 2005 (26th) | Jennifer Lopez | Monster-in-Law | Charlie Cantilini |
| 2005 (26th) | Tara Reid | Alone in the Dark | Aline Cedrac |
| 2006 (27th) | Sharon Stone | Basic Instinct 2 | Catherine Tramell |
| 2006 (27th) | Hilary and Haylie Duff | Material Girls | Tanzie and Ava Marchetta |
| 2006 (27th) | Lindsay Lohan | Just My Luck | Ashley Albright |
| 2006 (27th) | Kristanna Loken | BloodRayne | Rayne |
| 2006 (27th) | Jessica Simpson | Employee of the Month | Amy Renfro |
| 2007 (28th) | Lindsay Lohan | I Know Who Killed Me | Dakota Moss and Aubrey Fleming |
| 2007 (28th) | Jessica Alba | Awake | Sam Lockwood |
| 2007 (28th) | Jessica Alba | Fantastic Four: Rise of the Silver Surfer | Sue Storm / Invisible Woman |
| 2007 (28th) | Jessica Alba | Good Luck Chuck | Cam Wexler |
| 2007 (28th) | Logan Browning, Janel Parrish, Nathalia Ramos and Skyler Shaye | Bratz | Sasha, Jade, Yasmin and Cloe |
| 2007 (28th) | Elisha Cuthbert | Captivity | Jennifer Tree |
| 2007 (28th) | Diane Keaton | Because I Said So | Daphne Wilder |
| 2008 (29th) | Paris Hilton | The Hottie and the Nottie | Cristabel Abbott |
| 2008 (29th) | Jessica Alba | The Eye | Sydney Wells |
| 2008 (29th) | Jessica Alba | The Love Guru | Jane Bullard |
| 2008 (29th) | Annette Bening, Eva Mendes, Debra Messing, Jada Pinkett Smith and Meg Ryan | The Women | Sylvie Fowler, Crystal Allen, Edie Cohen, Alex Fisher and Mary Haines |
| 2008 (29th) | Cameron Diaz | What Happens in Vegas | Joy McNally |
| 2008 (29th) | Kate Hudson | Fool's Gold | Tess Finnegan |
| 2008 (29th) | Kate Hudson | My Best Friend's Girl | Alexis |
| 2009 (30th) | Sandra Bullock | All About Steve | Mary Horowitz |
| 2009 (30th) | Beyoncé | Obsessed | Sharon Charles |
| 2009 (30th) | Miley Cyrus | Hannah Montana: The Movie | Miley Stewart / Hannah Montana |
| 2009 (30th) | Megan Fox | Jennifer's Body | Jennifer Check |
| 2009 (30th) | Megan Fox | Transformers: Revenge of the Fallen | Mikaela Banes |
| 2009 (30th) | Sarah Jessica Parker | Did You Hear About the Morgans? | Meryl Morgan |