Manchester United F.C. mùa giải 2000–01
Ngoại hạng Anh

| Ngày | Đối thủ | Sân nhà/sân khách | Kết quả | Cầu thủ ghi bàn | số lượng khán giả | Thứ hạng |
| --- | --- | --- | --- | --- | --- | --- |
| 20/8/2000 | Newcastle United | H | 2–0 | Johnsen 20', Cole 69' | 67,477 | 5 |
| 22/8/2000 | Ipswich Town | A | 1–1 | Beckham 39' | 22,007 | 3 |
| 26/8/2000 | West Ham United | A | 2–2 | Beckham 6', Cole 49' | 25,998 | 5 |
| 5/9/2000 | Bradford City | H | 6–0 | Cole 11', Fortune (2) 23', 60', Sheringham (2) 71', 81', Beckham 85' | 67,447 | 1 |
| 9/9/2000 | Sunderland | H | 3–0 | Scholes (2) 14', 82', Sheringham 76' | 67,503 | 1 |
| 16/9/2000 | Everton | A | 3–1 | Butt 26', Giggs 29', Solskjær 38' | 38,541 | 1 |
| 23/9/2000 | Chelsea | H | 3–3 | Scholes 14', Sheringham 37', Beckham 39' | 67,568 | 1 |
| 1/10/2000 | Arsenal | A | 0–1 |  | 38,146 | 2 |
| 14/10/2000 | Leicester City | A | 3–0 | Sheringham (2) 37', 54', Solskjær 90' | 22,132 | 1 |
| 21/10/2000 | Leeds United | H | 3–0 | Yorke 40', Beckham 50', Jones 82' (o.g.) | 67,523 | 1 |
| 28/10/2000 | Southampton | H | 5–0 | Cole (2) 9', 73', Sheringham (3) 45', 51', 55' | 67,581 | 1 |
| 4/11/2000 | Coventry City | A | 2–1 | Cole 27', Beckham 37' | 21,079 | 1 |
| 11/11/2000 | Middlesbrough | H | 2–1 | Butt 62', Sheringham 65' | 67,576 | 1 |
| 18/11/2000 | Manchester City | A | 1–0 | Beckham 2' | 34,429 | 1 |
| 25/11/2000 | Derby County | A | 3–0 | Sheringham 61', Butt 69', Yorke 76' | 32,910 | 1 |
| 2/12/2000 | Tottenham Hotspur | H | 2–0 | Scholes 40', Solskjær 84' | 67,583 | 1 |
| 9/12/2000 | Charlton Athletic | A | 3–3 | Giggs 42', Solskjær 43', Keane 66' | 20,043 | 1 |
| 17/12/2000 | Liverpool | H | 0–1 |  | 67,533 | 1 |
| 23/12/2000 | Ipswich Town | H | 2–0 | Solskjær (2) 20', 32' | 67,597 | 1 |
| 26/12/2000 | Aston Villa | A | 1–0 | Solskjær 85' | 40,889 | 1 |
| 30/12/2000 | Newcastle United | A | 1–1 | Beckham 25' (pen.) | 52,134 | 1 |
| 1/1/2001 | West Ham United | H | 3–1 | Solskjær 3', Pearce 33' (o.g.), Yorke 57' | 67,603 | 1 |
| 13/1/2001 | Bradford City | A | 3–0 | Sheringham 72', Giggs 75', Chadwick 87' | 20,551 | 1 |
| 20/1/2001 | Aston Villa | H | 2–0 | G. Neville 57', Sheringham 87' | 67,533 | 1 |
| 31/1/2001 | Sunderland | A | 1–0 | Cole 46' | 48,260 | 1 |
| 3/2/2001 | Everton | H | 1–0 | Watson 52' (o.g.) | 67,528 | 1 |
| 10/2/2001 | Chelsea | A | 1–1 | Cole 69' | 34,960 | 1 |
| 25/2/2001 | Arsenal | H | 6–1 | Yorke (3) 3', 18', 22', Keane 26', Solskjær 38', Sheringham 90' | 67,535 | 1 |
| 3/3/2001 | Leeds United | A | 1–1 | Chadwick 64' | 40,055 | 1 |
| 17/3/2001 | Leicester City | H | 2–0 | Yorke 88', Silvestre 90' | 67,516 | 1 |
| 31/3/2001 | Liverpool | A | 0–2 |  | 44,806 | 1 |
| 10/4/2001 | Charlton Athletic | H | 2–1 | Cole 45', Solskjær 82' | 67,505 | 1 |
| 14/4/2001 | Coventry City | H | 4–2 | Yorke (2) 13', 28', Giggs 81', Scholes 87' | 67,637 | 1 |
| 21/4/2001 | Manchester City | H | 1–1 | Sheringham 71' (pen.) | 67,535 | 1 |
| 28/4/2001 | Middlesbrough | A | 2–0 | P. Neville 4', Beckham 84' | 34,417 | 1 |
| 5/5/2001 | Derby County | H | 0–1 |  | 67,526 | 1 |
| 13/5/2001 | Southampton | A | 1–2 | Giggs 71' | 15,526 | 1 |
| 19/5/2001 | Tottenham Hotspur | A | 1–3 | Scholes 22' | 36,072 | 1 |