Giải SAG cho nữ diễn viên chính xuất sắc nhất
Các người đoạt giải và các người được đề cử > Thập niên 2000

| Năm | Đề cử và nữ diễn viên thắng giải | Phim | Vai diễn |
| --- | --- | --- | --- |
| 2000 | Julia Roberts | Erin Brockovich | Erin Brockovich † |
| 2000 | Joan Allen | The Contender | Laine Billings Hanson ‡ |
| 2000 | Juliette Binoche | Chocolat | Vianne Rocher ‡ |
| 2000 | Ellen Burstyn | Requiem for a Dream | Sara Goldfarb ‡ |
| 2000 | Laura Linney | You Can Count on Me | Samantha "Sammy" Prescott ‡ |
| 2001 | Halle Berry | Monster's Ball | Leticia Musgrove † |
| 2001 | Jennifer Connelly | A Beautiful Mind | Alicia Nash |
| 2001 | Judi Dench | Iris | Iris Murdoch ‡ |
| 2001 | Sissy Spacek | In the Bedroom | Ruth Fowler ‡ |
| 2001 | Renée Zellweger | Bridget Jones's Diary | Bridget Jones ‡ |
| 2002 | Renée Zellweger | Chicago | Roxie Hart ‡ |
| 2002 | Salma Hayek | Frida | Frida Kahlo ‡ |
| 2002 | Nicole Kidman | The Hours | Virginia Woolf † |
| 2002 | Diane Lane | Unfaithful | Connie Sumner ‡ |
| 2002 | Julianne Moore | Far from Heaven | Cathy Whitaker ‡ |
| 2003 | Charlize Theron | Monster | Aileen Wuornos † |
| 2003 | Patricia Clarkson | The Station Agent | Olivia Harris |
| 2003 | Diane Keaton | Something's Gotta Give | Erica Barry ‡ |
| 2003 | Naomi Watts | 21 Grams | Cristina Peck ‡ |
| 2003 | Evan Rachel Wood | thirteen | Tracy Louise Freeland |
| 2004 | Hilary Swank | Million Dollar Baby | Maggie Fitzgerald † |
| 2004 | Annette Bening | Being Julia | Julia Lambert ‡ |
| 2004 | Catalina Sandino Moreno | Maria Full of Grace | María Álvarez ‡ |
| 2004 | Imelda Staunton | Vera Drake | Vera Drake ‡ |
| 2004 | Kate Winslet | Eternal Sunshine of the Spotless Mind | Clementine Kruczynski ‡ |
| 2005 | Reese Witherspoon | Walk the Line | June Carter † |
| 2005 | Judi Dench | Mrs. Henderson Presents | Laura Henderson ‡ |
| 2005 | Felicity Huffman | Transamerica | Stanley Schupak/Sabrina "Bree" Osbourne ‡ |
| 2005 | Charlize Theron | North Country | Josey Aimes ‡ |
| 2005 | Chương Tử Di | Memoirs of a Geisha | Chiyo Sakamoto/Sayuri Nitta |
| 2006 | Helen Mirren | The Queen | Queen Elizabeth II † |
| 2006 | Penélope Cruz | To Return (Volver) | Raimunda ‡ |
| 2006 | Judi Dench | Notes on a Scandal | Barbara Covett ‡ |
| 2006 | Meryl Streep | The Devil Wears Prada | Miranda Priestly ‡ |
| 2006 | Kate Winslet | Little Children | Sarah Pierce ‡ |
| 2007 | Julie Christie | Away From Her | Fiona Anderson ‡ |
| 2007 | Cate Blanchett | Elizabeth: The Golden Age | Queen Elizabeth I ‡ |
| 2007 | Marion Cotillard | La Vie en Rose | Edith Piaf † |
| 2007 | Angelina Jolie | A Mighty Heart | Mariane Pearl |
| 2007 | Ellen Page | Juno | Juno MacGuff ‡ |
| 2008 | Meryl Streep | Doubt | Aloysius Beauvier ‡ |
| 2008 | Anne Hathaway | Rachel Getting Married | Kym ‡ |
| 2008 | Angelina Jolie | Changeling | Christine Collins ‡ |
| 2008 | Melissa Leo | Frozen River | Ray Eddy ‡ |
| 2008 | Kate Winslet | Revolutionary Road | April Wheeler |
| 2009 | Sandra Bullock | The Blind Side | Leigh Anne Tuohy † |
| 2009 | Helen Mirren | The Last Station | Sophia Tolstaya ‡ |
| 2009 | Carey Mulligan | An Education | Jenny Miller ‡ |
| 2009 | Gabourey Sidibe | Precious  | Claireece "Precious" Jones ‡ |
| 2009 | Meryl Streep | Julie & Julia | Julia Child ‡ |