Giải Quả cầu vàng cho phim chính kịch hay nhất
Danh sách cụ thể > Thập niên 2000

| Năm | Phim | Đạo diễn | Nhà sản xuất |
| --- | --- | --- | --- |
| 2000 | Gladiator † | Ridley Scott | Douglas Wick |
| 2000 | Billy Elliot | Stephen Daldry | Charles Brand |
| 2000 | Erin Brockovich * | Steven Soderbergh | Danny DeVito |
| 2000 | Sunshine | István Szabó | András Hámori |
| 2000 | Traffic * | Steven Soderbergh | Edward Zwick |
| 2000 | Wonder Boys | Curtis Hanson | Curtis Hanson |
| 2001 | A Beautiful Mind † | Ron Howard | Brian Grazer |
| 2001 | In the Bedroom * | Todd Field | Todd Field |
| 2001 | Chúa tể những chiếc nhẫn: Hiệp hội nhẫn thần * | Peter Jackson | Peter Jackson, Barrie M. Osborne, Fran Walsh |
| 2001 | The Man Who Wasn't There | Joel Coen | Ethan Coen |
| 2001 | Mulholland Drive | David Lynch | Pierre Edelman |
| 2002 | The Hours *  | Stephen Daldry | Robert Fox và Scott Rudin |
| 2002 | About Schmidt | Alexander Payne | Michael Besman |
| 2002 | Gangs of New York *  | Martin Scorsese | Alberto Grimaldi |
| 2002 | Chúa tể những chiếc nhẫn: Hai tòa tháp * | Peter Jackson | Peter Jackson, Barrie M. Osborne, Fran Walsh |
| 2002 | The Pianist * | Roman Polanski | Roman Polanski |
| 2003 | Chúa tể những chiếc nhẫn: Sự trở lại của nhà vua † | Peter Jackson | Peter Jackson, Barrie M. Osborne, Fran Walsh |
| 2003 | Cold Mountain | Anthony Minghella | Albert Berger |
| 2003 | Master and Commander: The Far Side of the World * | Peter Weir | Peter Weir |
| 2003 | Mystic River * | Clint Eastwood | Robert Lorenz |
| 2003 | Seabiscuit * | Gary Ross | Kathleen Kennedy |
| 2004 | The Aviator * | Martin Scorsese | Michael Mann |
| 2004 | Closer | Mike Nichols | Patrick Marber |
| 2004 | Finding Neverland * | Marc Forster | Richard N. Gladstein |
| 2004 | Hotel Rwanda | Terry George | Terry George |
| 2004 | Kinsey | Bill Condon | Gail Mutrux |
| 2004 | Cô gái triệu đô † | Clint Eastwood | Clint Eastwood, Albert S. Ruddy, Tom Rosenberg |
| 2005 | Brokeback Mountain * | Ang Lee | Diana Ossana |
| 2005 | The Constant Gardener | Fernando Meirelles | Simon Channing-Williams |
| 2005 | Good Night, and Good Luck * | George Clooney | Grant Heslov |
| 2005 | A History of Violence | David Cronenberg | Chris Bender |
| 2005 | Match Point | Woody Allen | Letty Aronson |
| 2006 | Babel * | Alejandro González Iñárritu | Steve Golin |
| 2006 | Bobby | Emilio Estevez | Anthony Hopkins |
| 2006 | Điệp vụ Boston † | Martin Scorsese | Brad Grey |
| 2006 | Little Children | Todd Field | Albert Berger |
| 2006 | The Queen * | Stephen Frears | François Ivernel |
| 2007 | Chuộc lỗi * | Joe Wright | Tim Bevan |
| 2007 | American Gangster | Ridley Scott | Brian Grazer |
| 2007 | Eastern Promises | David Cronenberg | Paul Webster |
| 2007 | The Great Debaters | Denzel Washington | Oprah Winfrey |
| 2007 | Michael Clayton * | Tony Gilroy | Sydney Pollack |
| 2007 | Không chốn dung thân † | Joel và Ethan Coen | Joel Coen, Ethan Coen, Scott Rudin |
| 2007 | There Will Be Blood * | Paul Thomas Anderson | Paul Thomas Anderson |
| 2008 | Triệu phú ổ chuột † | Danny Boyle | Christian Colson |
| 2008 | Dị nhân Benjamin * | David Fincher | Kathleen Kennedy, Frank Marshall, Ray Stark |
| 2008 | Frost/Nixon * | Ron Howard | Tim Bevan, Eric Fellner, Brian Grazer, Ron Howard |
| 2008 | The Reader * | Stephen Daldry | Anthony Minghella, Sydney Pollack, Scott Rudin |
| 2008 | Revolutionary Road | Sam Mendes | Bobby Cohen, Sam Mendes, Scott Rudin |
| 2009 | Avatar * | James Cameron | James Cameron và Jon Landau |
| 2009 | The Hurt Locker † | Kathryn Bigelow | Kathryn Bigelow, Mark Boal, Nicolas Chartier, Tony Mark, Donall McCusker, Greg Shapiro |
| 2009 | Định mệnh * | Quentin Tarantino | Lawrence Bender |
| 2009 | Precious * | Lee Daniels | Lisa Cortes, Sarah Siegel-Magness, Valerie Hoffman, Asger Hussain, Gary Magness, Mark G. Magges, Berrgen Swason, Simone Sheffield |
| 2009 | Up in the Air * | Jason Reitman | Daniel Dubiecki, Jeffrey Clifford, Ivan Reitman, Jason Reitman |