Alfred G. Gilman
Các tác phẩm khoa học then chốt

Norepinephrine stimulated increase of cyclic AMP levels in developing mouse brain cell cultures. Science. 1971 Oct 15;174(6):292. PMID 4330303.
Regulation of adenosine 3',5'-cyclic monophosphate metabolism in cultured neuroblastoma cells. Nature. 1971 Dec 10;234(5328):356-8. PMID 4332686.
Fluorescent modification of adenosine 3',5'-monophosphate: spectroscopic properties and activity in enzyme systems. Science. 1972 Jul 21;177(45):279-80. PMID 4339302.
The regulatory component of adenylate cyclase. Purification and properties. J Biol Chem. 1981 Nov 25;256(22):11517-26. PMID 6271754.
The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein. J Biol Chem. 1981 Dec 25;256(24):12911-9. PMID 6273414.
Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase. J Biol Chem. 1982 Jan 10;257(1):20-3. PMID 6273425.
The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding. J Biol Chem. 1982 Oct 10;257(19):11416-23. PMID 6288684.
The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins. J Biol Chem. 1983 Jun 10;258(11):7059-63. PMID 6304074.
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit. J Biol Chem. 1983 Sep 25;258(18):11361-8. PMID 6309843.
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit. J Biol Chem. 1983 Sep 25;258(18):11369-76. PMID 6309844.
Homologies between signal transducing G proteins and ras gene products. Science. 1984 Nov 16;226(4676):860-2. PMID 6436980.
G proteins and dual control of adenylate cyclase. Cell. 1984 Mar;36(3):577-9. PMID 6321035.
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Cell. 1984 Dec;39(2 Pt 1):301-8. PMID 6094010.
Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase. Science. 1985 Sep 20;229(4719):1274-7. PMID 3839937.
Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels. Science. 1989 Feb 10;243(4892):804-7. PMID 2536957.
Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure. Science. 1989 Jun 30;244(4912):1558-64. PMID 2472670.
Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. Science. 1991 Dec 6;254(5037):1500-3. PMID 1962211.
Inhibition of adenylyl cyclase by Gi alpha. Science. 1993 Jul 9;261(5118):218-21. PMID 8327893.
Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature. 1994 Mar 17;368(6468):255-7. PMID 8145826.
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science. 1994 Sep 2;265(5177):1405-12. PMID 8073283.
Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin. Science. 1995 Jun 23;268(5218):1769-72. PMID 7792604.
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis. Science. 1995 Nov 10;270(5238):954-60. PMID 7481799.
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell. 1995 Dec 15;83(6):1047-58. PMID 8521505.
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. Cell. 1996 Aug 9;86(3):445-52. PMID 8756726.
Crystal structure of the adenylyl cyclase activator Gsalpha. Science. 1997 Dec 12;278(5345):1943-7. PMID 9395396.
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science. 1997 Dec 12;278(5345):1907-16. PMID 9417641.