Giải Oscar cho nam diễn viên chính xuất sắc nhất
Danh sách cụ thể > Thập niên 2000

| Năm | Diễn viên | Phim | Vai diễn | Chú thích |
| --- | --- | --- | --- | --- |
| 2000  (73)  | Russell Crowe ‡ | Gladiator | Maximus Decimus Meridius |  |
| 2000  (73)  | Javier Bardem | Before Night Falls | Reinaldo Arenas |  |
| 2000  (73)  | Tom Hanks | Cast Away | Chuck Noland |  |
| 2000  (73)  | Ed Harris | Pollock | Jackson Pollock |  |
| 2000  (73)  | Geoffrey Rush | Quills | The Marquis de Sade |  |
| 2001  (74)  | Denzel Washington ‡ | Training Day | Detective Alonzo Harris |  |
| 2001  (74)  | Russell Crowe | A Beautiful Mind | John Forbes Nash Jr. |  |
| 2001  (74)  | Sean Penn | I Am Sam | Sam Dawson |  |
| 2001  (74)  | Will Smith | Ali | Muhammad Ali |  |
| 2001  (74)  | Tom Wilkinson | In the Bedroom | Dr. Matt Fowler |  |
| 2002  (75)  | Adrien Brody ‡ | The Pianist | Władysław Szpilman |  |
| 2002  (75)  | Nicolas Cage | Adaptation | Charlie Kaufman Donald Kaufman |  |
| 2002  (75)  | Michael Caine | The Quiet American | Thomas Fowler |  |
| 2002  (75)  | Daniel Day-Lewis | Gangs of New York | William "Bill the Butcher" Cutting |  |
| 2002  (75)  | Jack Nicholson | About Schmidt | Warren R. Schmidt |  |
| 2003  (76)  | Sean Penn ‡ | Mystic River | Jimmy Markum |  |
| 2003  (76)  | Johnny Depp | Cướp biển vùng Caribbean: Lời nguyền tàu Ngọc Trai Đen | Jack Sparrow |  |
| 2003  (76)  | Ben Kingsley | House of Sand and Fog | Massoud Amir Behrani |  |
| 2003  (76)  | Jude Law | Cold Mountain | W. P. Inman |  |
| 2003  (76)  | Bill Murray | Lạc lối ở Tokyo | Bob Harris |  |
| 2004  (77)  | Jamie Foxx ‡ | Ray | Ray Charles |  |
| 2004  (77)  | Don Cheadle | Hotel Rwanda | Paul Rusesabagina |  |
| 2004  (77)  | Johnny Depp | Finding Neverland | J. M. Barrie |  |
| 2004  (77)  | Leonardo DiCaprio | The Aviator | Howard Hughes |  |
| 2004  (77)  | Clint Eastwood | Cô gái triệu đô | Frankie Dunn |  |
| 2005  (78)  | Philip Seymour Hoffman ‡ | Capote | Truman Capote |  |
| 2005  (78)  | Terrence Howard | Hustle & Flow | Djay |  |
| 2005  (78)  | Heath Ledger | Brokeback Mountain | Ennis Del Mar |  |
| 2005  (78)  | Joaquin Phoenix | Walk the Line | Johnny Cash |  |
| 2005  (78)  | David Strathairn | Good Night, and Good Luck | Edward R. Murrow |  |
| 2006  (79)  | Forest Whitaker ‡ | The Last King of Scotland | Idi Amin |  |
| 2006  (79)  | Leonardo DiCaprio | Blood Diamond | Danny Archer |  |
| 2006  (79)  | Ryan Gosling | Half Nelson | Dan Dunne |  |
| 2006  (79)  | Peter O'Toole | Venus | Maurice |  |
| 2006  (79)  | Will Smith | Mưu cầu hạnh phúc | Chris Gardner |  |
| 2007  (80)  | Daniel Day-Lewis ‡ | There Will Be Blood | Daniel Plainview |  |
| 2007  (80)  | George Clooney | Michael Clayton | Michael Clayton |  |
| 2007  (80)  | Johnny Depp | Sweeney Todd: The Demon Barber of Fleet Street | Sweeney Todd / Benjamin Barker |  |
| 2007  (80)  | Tommy Lee Jones | In the Valley of Elah | Hank Deerfield |  |
| 2007  (80)  | Viggo Mortensen | Eastern Promises | Nikolai Luzhin |  |
| 2008  (81)  | Sean Penn ‡ | Milk | Harvey Milk |  |
| 2008  (81)  | Richard Jenkins | The Visitor | Walter Vale |  |
| 2008  (81)  | Frank Langella | Frost/Nixon | Richard Nixon |  |
| 2008  (81)  | Brad Pitt | Dị nhân Benjamin | Benjamin Button |  |
| 2008  (81)  | Mickey Rourke | The Wrestler | Randy "The Ram" Robinson |  |
| 2009  (82)  | Jeff Bridges ‡ | Crazy Heart | Otis "Bad" Blake |  |
| 2009  (82)  | George Clooney | Up in the Air | Ryan Bingham |  |
| 2009  (82)  | Colin Firth | A Single Man | George Falconer |  |
| 2009  (82)  | Morgan Freeman | Invictus | Nelson Mandela |  |
| 2009  (82)  | Jeremy Renner | The Hurt Locker | SFC William James |  |