Giải quần vợt Mỹ Mở rộng 2018
Hạt giống đơn > Đơn nam

| Hạt giống | Xếp hạng | Tay vợt | Điểm trước thi đấu | Điểm bảo vệ | Điểm thắng | Điểm sau thi đấu | Thực trạng |
| --- | --- | --- | --- | --- | --- | --- | --- |
| 1 | 1 |  Rafael Nadal | 10,040 | 2,000 | 720 | 8,760 | Semifinals retired against  Juan Martín del Potro [3] |
| 2 | 2 |  Roger Federer | 7,080 | 360 | 180 | 6,900 | Fourth round lost to  John Millman |
| 3 | 3 |  Juan Martín del Potro | 5,500 | 720 | 1,200 | 5,980 | Runner-up, lost to  Novak Djokovic [6] |
| 4 | 4 |  Alexander Zverev | 4,845 | 45 | 90 | 4,890 | Third round lost to  Philipp Kohlschreiber |
| 5 | 5 |  Kevin Anderson | 4,615 | 1,200 | 180 | 3,595 | Fourth round lost to  Dominic Thiem [9] |
| 6 | 6 |  Novak Djokovic | 4,445 | 0 | 2,000 | 6,445 | Champion, defeated  Juan Martín del Potro [3] |
| 7 | 7 |  Marin Čilić | 4,445 | 90 | 360 | 4,715 | Quarterfinals lost to  Kei Nishikori [21] |
| 8 | 8 |  Grigor Dimitrov | 3,790 | 45 | 10 | 3,755 | First round lost to  Stan Wawrinka [WC] |
| 9 | 9 |  Dominic Thiem | 3,485 | 180 | 360 | 3,665 | Quarterfinals lost to  Rafael Nadal [1] |
| 10 | 10 |  David Goffin | 3,435 | 180 | 180 | 3,435 | Fourth round lost to  Marin Čilić [7] |
| 11 | 11 |  John Isner | 3,200 | 90 | 360 | 3,470 | Quarterfinals lost to  Juan Martín del Potro [3] |
| 12 | 12 |  Pablo Carreño Busta | 2,425 | 720 | 45 | 1,750 | Second round retired against  João Sousa |
| 13 | 13 |  Diego Schwartzman | 2,380 | 360 | 90 | 2,110 | Third round lost to  Kei Nishikori [21] |
| 14 | 14 |  Fabio Fognini | 2,190 | 10 | 45 | 2,225 | Second round lost to  John Millman |
| 15 | 15 |  Stefanos Tsitsipas | 2,042 | (125)† | 45 | 1,962 | Second round lost to  Daniil Medvedev |
| 16 | 16 |  Kyle Edmund | 1,935 | 90 | 10 | 1,855 | First round lost to  Paolo Lorenzi |
| 17 | 17 |  Lucas Pouille | 1,915 | 180 | 90 | 1,825 | Third round lost to  João Sousa |
| 18 | 18 |  Jack Sock | 1,815 | 10 | 45 | 1,850 | Second round lost to  Nikoloz Basilashvili |
| 19 | 22 |  Roberto Bautista Agut | 1,650 | 90 | 10 | 1,570 | First round lost to  Jason Kubler [WC] |
| 20 | 20 |  Borna Ćorić | 1,735 | 90 | 180 | 1,825 | Fourth round lost to  Juan Martin del Potro [3] |
| 21 | 19 |  Kei Nishikori | 1,755 | 0 | 720 | 2,475 | Semifinals lost to  Novak Djokovic [6] |
| 22 | 21 |  Marco Cecchinato | 1,734 | (48)† | 10 | 1,696 | First round lost to  Julien Benneteau |
| 23 | 23 |  Chung Hyeon | 1,630 | 45 | 45 | 1,630 | Second round lost to  Mikhail Kukushkin |
| 24 | 27 |  Damir Džumhur | 1,475 | 90 | 10 | 1,395 | First round lost to  Dušan Lajović |
| 25 | 24 |  Milos Raonic | 1,575 | 0 | 180 | 1,755 | Fourth round lost to  John Isner [11] |
| 26 | 25 |  Richard Gasquet | 1,535 | 10 | 90 | 1,615 | Third round lost to  Novak Djokovic [6] |
| 27 | 26 |  Karen Khachanov | 1,525 | 10 | 90 | 1,605 | Third round lost to  Rafael Nadal [1] |
| 28 | 28 |  Denis Shapovalov | 1,385 | 205 | 90 | 1,270 | Third round lost to  Kevin Anderson [5] |
| 29 | 29 |  Adrian Mannarino | 1,365 | 90 | 10 | 1,285 | First round lost to  Frances Tiafoe |
| 30 | 30 |  Nick Kyrgios | 1,345 | 10 | 90 | 1,425 | Third round lost to  Roger Federer [2] |
| 31 | 32 |  Fernando Verdasco | 1,330 | 45 | 90 | 1,375 | Third round lost to  Juan Martín del Potro [3] |
| 32 | 33 |  Filip Krajinović | 1,314 | (29)+(33)† | 10+20 | 1,282 | First round retired against  Matthew Ebden |
†The player did not qualify for the tournament in 2017, but is defending points from one or more 2017 ATP Challenger Tour tournaments.