En İyi Komedi Performansı MTV Film Ödülü
Adaylar ve kazananlar > 2000'ler

| Yıl | Adaylar ve kazananlar | Film | Rol |
| --- | --- | --- | --- |
| 2000 | Adam Sandler | Süper Baba (Big Daddy) | Sonny Koufax |
| 2000 | Jason Biggs | Amerikan Pastası (American Pie) | Jim Levenstein |
| 2000 | Ice Cube | Next Friday | Craig Jones |
| 2000 | Mike Myers | Avanak Ajan (Austin Powers: The Spy Who Shagged Me) | Austin Powers / Dr. Evil / Fat Bastard |
| 2000 | Parker Posey | Çığlık 3 (Scream 3) | Jennifer Jolie |
| 2001 | Ben Stiller | Zor Baba (Meet the Parents) | Greg Focker |
| 2001 | Jim Carrey | Ben, Kendim ve Sevgilim (Me, Myself & Irene) | Charlie Baileygates / Hank |
| 2001 | Tom Green | Geyik Muhabbeti (Road Trip) | Barry |
| 2001 | Martin Lawrence | Vay Anam Vay (Big Momma's House) | Malcom Turner / Sahte Big Momma |
| 2001 | Eddie Murphy | Çatlak Profesör 2 (Nutty Professor II: The Klumps) | Çeşitli karakterler |
| 2002 | Reese Witherspoon | Legally Blonde | Elle Woods |
| 2002 | Eddie Murphy | Şrek (Shrek) | Eşek |
| 2002 | Mike Myers | Şrek (Shrek) | Şrek |
| 2002 | Seann William Scott | Amerikan Pastası 2 (American Pie 2) | Stifler |
| 2002 | Chris Tucker | Rush Hour 2 | James Carter |
| 2003 | Mike Myers | Avanak Ajan: Altın Kuş (Austin Powers in Goldmember) | Austin Powers / Dr. Evil / Goldmember / Fat Bastard |
| 2003 | Cedric the Entertainer | Barbershop | Eddie |
| 2003 | Will Ferrell | Eski Dostlar (Old School) | Frank Ricard |
| 2003 | Johnny Knoxville | Jackass: The Movie | Kendisi |
| 2003 | Adam Sandler | Kazara Zengin (Mr. Deeds) | Longfellow Deeds |
| 2004 | Jack Black | Hababam Rock (School of Rock) | Dewey Finn |
| 2004 | Jim Carrey | Aman Tanrım! (Bruce Almighty) | Bruce Nolan |
| 2004 | Ellen DeGeneres | Kayıp Balık Nemo (Finding Nemo) | Dory |
| 2004 | Johnny Depp | Karayip Korsanları: Siyah İnci'nin Laneti (Pirates of the Caribbean: The Curse of the Black Pearl) | Jack Sparrow |
| 2004 | Will Ferrell | Elf | Elf Buddy |
| 2005 | Dustin Hoffman | Zor Baba ve Dünür (Meet the Fockers) | Bernie Focker |
| 2005 | Antonio Banderas | Şrek 2 | Çizmeli Kedi |
| 2005 | Will Ferrell | Anchorman: O Bir Efsane (Anchorman: The Legend of Ron Burgundy) | Ron Burgundy |
| 2005 | Will Smith | Aşk Doktoru (Hitch) | Alex "Hitch" Hitchens |
| 2005 | Ben Stiller | Yakar Top (DodgeBall: A True Underdog Story) | White Goodman |
| 2006 | Steve Carell | 40 Yıllık Bekar (The 40-Year-Old Virgin) | Andy Stitzer |
| 2006 | Tyler Perry | Madea's Family Reunion | Madea |
| 2006 | Adam Sandler | En Uzun Mesafe (The Longest Yard) | Paul Crewe |
| 2006 | Vince Vaughn | Davetsiz Çapkınlar (Wedding Crashers) | Jeremy Grey |
| 2006 | Owen Wilson | Davetsiz Çapkınlar (Wedding Crashers) | John Beckwith |
| 2007 | Sacha Baron Cohen | Borat | Borat Sagdiyev |
| 2007 | Emily Blunt | Şeytan Marka Giyer (The Devil Wears Prada) | Emily Charlton |
| 2007 | Will Ferrell | Blades of Glory | Chazz Michael Michaels |
| 2007 | Adam Sandler | Click | Michael Newman |
| 2007 | Ben Stiller | Müzede Bir Gece (Night at the Museum) | Larry Daley |
| 2008 | Johnny Depp | Karayip Korsanları: Dünyanın Sonu (Pirates of the Caribbean: At World's End) | Jack Sparrow |
| 2008 | Amy Adams | Manhattan'da Sihir (Enchanted) | Prenses Giselle |
| 2008 | Jonah Hill | Çok Fena (Superbad) | Seth |
| 2008 | Seth Rogen | Kaza Kurşunu (Knocked Up) | Ben Stone |
| 2008 | Adam Sandler | Damadı Öpebilirsin (I Now Pronounce You Chuck and Larry) | Chuck Levine |
| 2009 | Jim Carrey | Bay Evet (Yes Man) | Carl Allen |
| 2009 | Steve Carell | Akıllı Ol (Get Smart) | Maxwell Smart |
| 2009 | Anna Faris | The House Bunny | Shelley Darlington |
| 2009 | James Franco | Üşütük Kafalar (Pineapple Express) | Saul Silver |
| 2009 | Amy Poehler | Baby Mama | Angie Ostrowski |