2021-22 Beker van België
6. Tur

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| 26 Ekim 2021 | KV Oostende | 8-1 | Onhaye | Oostende |
| 20.00 OAYS | Kvasina  5', 26', 41' Fortès  37' Atanga  50', 60' Ambrose  75' (pen.) Ndicka  80' |  | Delplank  3' | Stadyum: Diaz Arena  |
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| 26 Ekim 2021 | RWDM | 1-2 | Zulte Waregem | Molenbeek-Saint-Jean |
| 20.30 OAS | Nangis  40' |  | Kutesa  1' Vossen  90+2' (pen.) | Stadyum: Edmond Machtens Stadyumu  |
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| 26 Ekim 2021 | KV Mechelen | 2-1 | Union SG | Mechelen |
| 20.30 OAYS | Shved  16' Hairemans  65' |  | Vanzeir  82' | Stadyum: AFAS-stadion Achter de Kazerne  Hakem: Arthur Denil  |
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| 26 Ekim 2021 | Excel Mouscron | 0-1 | R. Standard de Liège | Mouscron |
| 20.45 OAYS |  |  | Klauss  7' (pen.) | Stadyum: Stade Le Canonnier  Seyirci: 4.000 Hakem: Alexandre Boucaut  |
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| 27 Ekim 2021 | Dender EH | 0-1 | KASEupen |  |
| 20.00 OAS |  |  | Gnaka  7' |  |
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| 27 Ekim 2021 | Sint-Eloois-Winkel | 0-6 | KRC Genk | Sportpark Terschueren, Sint-Eloois-Winkel |
| 20.00 OAYS |  |  | Ugbo  34' (pen.), 80' Arteaga  36', 38' Paintsil  44' Toma  87' |  |
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| 27 Ekim 2021 | KAA Gent | 4-0 | Belisia | Ghelamco Arena, Gent |
| 20.00 OAYS | Odjidja-Ofoe  6' Okumu  25' Mboyo  43' Chakvetadze  64' (pen.) |  |  |  |
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| 27 Ekim 2021 | Knokke | 1-1 (uz.) (1-2 p) | Kortrijk |  |
| 20.00 OAS | Lambo  79' |  | Kadri  51' |  |
|   |   | Penaltılar |   |  |
|   |  Mariën   Binst   Van den Bossche   Vanraefelghem   Bailly   |   |  D'haene   Rougeaux   Palaversa   Sainsbury   |  |
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| 27 Ekim 2021 | R.FC Seraing | 3-2 (uz.) | Sint-Truidense |  |
| 20.00 OAS | Mouandilmadji  35' Maziz  80', 104' |  | Matsubara  53' Koita  57' |  |
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| 27 Ekim 2021 | R. Charleroi SC | 0-0 (uz.) (3-4 p) | Lommel | Stade du Pays de Charleroi, Charleroi |
20.00 OAYS: 
|   |   | Penaltılar |   |  |
|   |  Morioka   Zaroury   Gholizadeh   Van Cleemput   Gillet   |   |  Roque   Henkens   Vandersmissen   Sales   Þórðarson   |  |
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| 27 Ekim 2021 | Francs Borains | 0-4 | K Beerschot VA |  |
| 20.30 OAS |  |  | Noubissi  2' Caicedo  58' Holzhauser  80' Vaca  90' |  |
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| 27 Ekim 2021 | Club Brugge | 3-0 | Deinze | Jan Breydelstadion, Brugge |
| 20.45 OAYS | Izquierdo  48' Dost  74', 77' |  |  |  |
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| 27 Ekim 2021 | Lierse Kempenzonen | 1-2 | OH Leuven |  |
| 20.45 OAS | Liongola  80' |  | Kaba  62' (pen.), 86' |  |
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| 27 Ekim 2021 | RAAL La Louvière | 1-7 | RSC Anderlecht | Stade Communal du Tivoli, La Louvière |
| 20.45 OAYS | Franco  35' (pen.) |  | Zirkzee  20', 45' Hoedt  32', 90' Refaelov  39', 79' Raman  75' |  |
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| 28 Ekim 2021 | Cercle Brugge | 3-0 | KVK Tienen | Jan Breydelstadion, Brugge |
| 20.00 OAYS | Denkey  33' Matondo  42' Cassaert  63' |  |  |  |
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| 28 Ekim 2021 | KVC Westerlo | 2-1 | R.Antwerp FC |  |
| 20.00 OAS | Van den Keybus  32' Foster  44' |  | Samatta  75' |  |