Komedi Dizisinde Kadın Oyuncu Tarafından Üstün Performans Ekran Oyuncuları Derneği Ödülü
Kazananlar ve adaylar > 2000’ler

| Yıl | Adaylar | Dizi | Rol | Kanal |
| --- | --- | --- | --- | --- |
| 2000 (7th)  | Sarah Jessica Parker | Sex and the City | Carrie Bradshaw | HBO |
| 2000 (7th)  | Calista Flockhart | Ally McBeal | Ally McBeal | FOX |
| 2000 (7th)  | Jane Kaczmarek | Malcolm in the Middle | Lois | FOX |
| 2000 (7th)  | Debra Messing | Will & Grace | Grace Adler | NBC |
| 2000 (7th)  | Megan Mullally | Will & Grace | Karen Walker | NBC |
| 2001 (8th)  | Megan Mullally | Will & Grace | Karen Walker | NBC |
| 2001 (8th)  | Jennifer Aniston | Friends | Rachel Green | NBC |
| 2001 (8th)  | Kim Cattrall | Sex and the City | Samantha Jones | HBO |
| 2001 (8th)  | Patricia Heaton | Everybody Loves Raymond | Debra Barone | CBS |
| 2001 (8th)  | Sarah Jessica Parker | Sex and the City | Carrie Bradshaw | HBO |
| 2002 (9th)  | Megan Mullally | Will & Grace | Karen Walker | NBC |
| 2002 (9th)  | Jennifer Aniston | Friends | Rachel Green | NBC |
| 2002 (9th)  | Kim Cattrall | Sex and the City | Samantha Jones | HBO |
| 2002 (9th)  | Patricia Heaton | Everybody Loves Raymond | Debra Barone | CBS |
| 2002 (9th)  | Jane Kaczmarek | Malcolm in the Middle | Lois | FOX |
| 2003 (10th)  | Megan Mullally | Will & Grace | Karen Walker | NBC |
| 2003 (10th)  | Patricia Heaton | Everybody Loves Raymond | Debra Barone | CBS |
| 2003 (10th)  | Lisa Kudrow | Friends | Phoebe Buffay | NBC |
| 2003 (10th)  | Debra Messing | Will & Grace | Grace Adler | NBC |
| 2003 (10th)  | Doris Roberts | Everybody Loves Raymond | Marie Barone | CBS |
| 2004 (11th)  | Teri Hatcher | Desperate Housewives | Susan Mayer | ABC |
| 2004 (11th)  | Patricia Heaton | Everybody Loves Raymond | Debra Barone | CBS |
| 2004 (11th)  | Megan Mullally | Will & Grace | Karen Walker | NBC |
| 2004 (11th)  | Sarah Jessica Parker | Sex and the City | Carrie Bradshaw | HBO |
| 2004 (11th)  | Doris Roberts | Everybody Loves Raymond | Marie Barone | CBS |
| 2005 (12th)  | Felicity Huffman | Desperate Housewives | Lynette Scavo | ABC |
| 2005 (12th)  | Candice Bergen | Boston Legal | Shirley Schmidt | ABC |
| 2005 (12th)  | Patricia Heaton | Everybody Loves Raymond | Debra Barone | CBS |
| 2005 (12th)  | Megan Mullally | Will & Grace | Karen Walker | NBC |
| 2005 (12th)  | Mary-Louise Parker | Weeds | Nancy Botwin | Showtime |
| 2006 (13th)  | America Ferrera | Ugly Betty | Betty Suarez | ABC |
| 2006 (13th)  | Felicity Huffman | Desperate Housewives | Lynette Scavo | ABC |
| 2006 (13th)  | Julia Louis-Dreyfus | The New Adventures of Old Christine | Christine Campbell | CBS |
| 2006 (13th)  | Megan Mullally | Will & Grace | Karen Walker | NBC |
| 2006 (13th)  | Mary-Louise Parker | Weeds | Nancy Botwin | Showtime |
| 2006 (13th)  | Jaime Pressly | My Name Is Earl | Joy Turner | NBC |
| 2007 (14th)  | Tina Fey | 30 Rock | Liz Lemon | NBC |
| 2007 (14th)  | Christina Applegate | Samantha Who? | Samantha Newly | ABC |
| 2007 (14th)  | America Ferrera | Ugly Betty | Betty Suarez | ABC |
| 2007 (14th)  | Mary-Louise Parker | Weeds | Nancy Botwin | Showtime |
| 2007 (14th)  | Vanessa L. Williams | Ugly Betty | Wilhelmina Slater | ABC |
| 2008 (15th)  | Tina Fey | 30 Rock | Liz Lemon | NBC |
| 2008 (15th)  | Christina Applegate | Samantha Who? | Samantha Newly | ABC |
| 2008 (15th)  | America Ferrera | Ugly Betty | Betty Suarez | ABC |
| 2008 (15th)  | Mary-Louise Parker | Weeds | Nancy Botwin | Showtime |
| 2008 (15th)  | Tracey Ullman | Tracey Ullman's State of the Union | Various Characters | Showtime |
| 2009 (16th)  | Tina Fey | 30 Rock | Liz Lemon | NBC |
| 2009 (16th)  | Christina Applegate | Samantha Who? | Samantha Newly | ABC |
| 2009 (16th)  | Toni Collette | The United States of Tara | Tara Gregson | Showtime |
| 2009 (16th)  | Edie Falco | Nurse Jackie | Jackie Peyton | Showtime |
| 2009 (16th)  | Julia Louis-Dreyfus | The New Adventures of Old Christine | Christine Campbell | CBS |