Başrolde Kadın Oyuncu Tarafından Üstün Performans Ekran Oyuncuları Derneği Ödülü
Kazananlar ve adaylar > 2000'ler

| Yıl | Aday | Film | Rol(ler) |
| --- | --- | --- | --- |
| 2000 (7.)  | Julia Roberts † | Erin Brockovich | Erin Brockovich |
| 2000 (7.)  | Joan Allen ‡ | The Contender | Laine Hanson |
| 2000 (7.)  | Juliette Binoche ‡ | Chocolat | Vianne Liberato |
| 2000 (7.)  | Ellen Burstyn ‡ | Requiem for a Dream | Sara Goldfarb |
| 2000 (7.)  | Laura Linney ‡ | You Can Count On Me | Sammy Taylor |
| 2001 (8.)  | Halle Berry † | Monster's Ball | Leticia Musgrove |
| 2001 (8.)  | Jennifer Connelly †† | A Beautiful Mind | Alicia Nash |
| 2001 (8.)  | Judi Dench ‡ | Iris | Iris Murdoch |
| 2001 (8.)  | Sissy Spacek ‡ | In the Bedroom | Ruth Fowler |
| 2001 (8.)  | Renée Zellweger ‡ | Bridget Jones's Diary | Bridget Jones |
| 2002 (9.)  | Renée Zellweger ‡ | Chicago | Roxie Hart |
| 2002 (9.)  | Salma Hayek ‡ | Frida | Frida Kahlo |
| 2002 (9.)  | Nicole Kidman † | The Hours | Virginia Woolf |
| 2002 (9.)  | Diane Lane ‡ | Unfaithful | Connie Sumner |
| 2002 (9.)  | Julianne Moore ‡ | Far from Heaven | Cathy Whitaker |
| 2003 (10.)  | Charlize Theron † | Monster | Aileen Wuornos |
| 2003 (10.)  | Patricia Clarkson | The Station Agent | Olivia Harris |
| 2003 (10.)  | Diane Keaton ‡ | Something's Gotta Give | Erica Barry |
| 2003 (10.)  | Naomi Watts ‡ | 21 Grams | Cristina Gallagher |
| 2003 (10.)  | Evan Rachel Wood | Thirteen | Tracy Freeland |
| 2004 (11.)  | Hilary Swank † | Million Dollar Baby | Maggie Fitzgerald |
| 2004 (11.)  | Annette Bening ‡ | Being Julia | Julia Lambert |
| 2004 (11.)  | Catalina Sandino Moreno ‡ | Maria Full of Grace | Maria Álvarez |
| 2004 (11.)  | Imelda Staunton ‡ | Vera Drake | Vera Drake |
| 2004 (11.)  | Kate Winslet ‡ | Eternal Sunshine of the Spotless Mind | Clemetine Kruczynski |
| 2005 (12.)  | Reese Witherspoon † | Walk the Line | June Carter |
| 2005 (12.)  | Judi Dench ‡ | Mrs Henderson Presents | Mrs. Laura Henderson |
| 2005 (12.)  | Felicity Huffman ‡ | Transamerica | Bree Hoffman |
| 2005 (12.)  | Charlize Theron ‡ | North Country | Josey Aimes |
| 2005 (12.)  | Ziyi Zhang | Memoirs of a Geisha | Sayuri Takanasja |
| 2006 (13.)  | Helen Mirren † | The Queen | Queen Elizabeth II |
| 2006 (13.)  | Penélope Cruz ‡ | Volver | Raimunda Nedine |
| 2006 (13.)  | Judi Dench ‡ | Notes on a Scandal | Barbara Covett |
| 2006 (13.)  | Meryl Streep ‡ | The Devil Wears Prada | Miranda Priestly |
| 2006 (13.)  | Kate Winslet ‡ | Little Children | Sarah Pierce |
| 2007 (14.)  | Julie Christie ‡ | Away from Her | Fiona Anderson |
| 2007 (14.)  | Cate Blanchett ‡ | Elizabeth: The Golden Age | Queen Elizabeth I |
| 2007 (14.)  | Marion Cotillard † | La Vie en Rose (La môme) | Edith Piaf |
| 2007 (14.)  | Angelina Jolie | A Mighty Heart | Mariane Pearl |
| 2007 (14.)  | Ellen Page ‡ | Juno | Juno MacGuff |
| 2008 (15.)  | Meryl Streep ‡ | Doubt | Sister Aloysius Beauvier |
| 2008 (15.)  | Anne Hathaway ‡ | Rachel Getting Married | Kym Ryder |
| 2008 (15.)  | Angelina Jolie ‡ | Changeling | Christine Collins |
| 2008 (15.)  | Melissa Leo ‡ | Frozen River | Ray Eddy |
| 2008 (15.)  | Kate Winslet | Revolutionary Road | April Wheeler |
| 2009 (16.)  | Sandra Bullock † | The Blind Side | Leigh Anne Tuohy |
| 2009 (16.)  | Helen Mirren ‡ | The Last Station | Sophia Tolstaya |
| 2009 (16.)  | Carey Mulligan ‡ | An Education | Jenny Mellor |
| 2009 (16.)  | Gabourey Sidibe ‡ | Precious | Precious Jones |
| 2009 (16.)  | Meryl Streep ‡ | Julie & Julia | Julia Child |