รางวัลออสการ์ สาขานักแสดงนำหญิงยอดเยี่ยม
ผู้ได้รับรางวัลและได้รับการเสนอชื่อเข้าชิง > คริสต์ทศวรรษ 2000

| ปี | นักแสดง | บทบาท | ภาพยนตร์ | อ้างอิง |
| --- | --- | --- | --- | --- |
2000s
| 2000  (73rd)  | Roberts !Julia Roberts ‡ | Brockovich !Erin Brockovich | Erin Brockovich |  |
| 2000  (73rd)  | Allen !Joan Allen | Hanson !Laine Hanson | Contender !The Contender |  |
| 2000  (73rd)  | Binoche !Juliette Binoche | Rocher !Vianne Rocher | Chocolat |  |
| 2000  (73rd)  | Burstyn !Ellen Burstyn | Goldfarb !Sara Goldfarb | Requiem for a Dream |  |
| 2000  (73rd)  | Linney !Laura Linney | Prescott !Samantha "Sammy" Prescott | You Can Count On Me |  |
| 2001  (74th)  | Berry !Halle Berry ‡ | Musgrove !Leticia Musgrove | Monster's Ball |  |
| 2001  (74th)  | Dench !Judi Dench | Murdoch !Iris Murdoch | Iris |  |
| 2001  (74th)  | Kidman !Nicole Kidman | Satine | Moulin Rouge! |  |
| 2001  (74th)  | Spacek !Sissy Spacek | Fowler !Ruth Fowler | In the Bedroom |  |
| 2001  (74th)  | Zellweger !Renée Zellweger | Jones !Bridget Jones | Bridget Jones's Diary |  |
| 2002  (75th)  | Kidman !Nicole Kidman ‡ | Woolf !Virginia Woolf | Hours !The Hours |  |
| 2002  (75th)  | Hayek !Salma Hayek | Kahlo !Frida Kahlo | Frida |  |
| 2002  (75th)  | Lane !Diane Lane | Sumner !Constance "Connie" Sumner | Unfaithful |  |
| 2002  (75th)  | Moore !Julianne Moore | Whitaker !Cathy Whitaker | Far from Heaven |  |
| 2002  (75th)  | Zellweger !Renée Zellweger | Hart !Roxie Hart | Chicago |  |
| 2003  (76th)  | Theron !Charlize Theron ‡ | Wuornos !Aileen "Lee" Wuornos | Monster |  |
| 2003  (76th)  | Castle-Hughes !Keisha Castle-Hughes | Apirana !Paikea Apirana | Whale Rider |  |
| 2003  (76th)  | Keaton !Diane Keaton | Berry !Erica Jane Berry | Something's Gotta Give |  |
| 2003  (76th)  | Morton !Samantha Morton | Sullivan !Sarah Sullivan | In America |  |
| 2003  (76th)  | Watts !Naomi Watts | Peck !Cristina Williams-Peck | 21 Grams |  |
| 2004  (77th)  | Swank !Hilary Swank ‡ | Fitzgerald !Maggie Fitzgerald | Million Dollar Baby |  |
| 2004  (77th)  | Bening !Annette Bening | Lambert !Julia Lambert | Being Julia |  |
| 2004  (77th)  | Sandino Moreno !Catalina Sandino Moreno | Álvarez !María Álvarez | Maria Full of Grace |  |
| 2004  (77th)  | Staunton !Imelda Staunton | Drake !Vera Rose Drake | Vera Drake |  |
| 2004  (77th)  | Winslet !Kate Winslet | Kruczynski !Clementine Kruczynski | Eternal Sunshine of the Spotless Mind |  |
| 2005  (78th)  | Witherspoon !Reese Witherspoon ‡ | Carter !June Carter Cash | Walk the Line |  |
| 2005  (78th)  | Dench !Judi Dench | Henderson !Laura Forster-Henderson | Mrs Henderson Presents |  |
| 2005  (78th)  | Huffman !Felicity Huffman | Osbourne !Sabrina "Bree" Osbourne | Transamerica |  |
| 2005  (78th)  | Knightley !Keira Knightley | Bennet !Elizabeth Bennet | Pride & Prejudice |  |
| 2005  (78th)  | Theron !Charlize Theron | Aimes !Josey Aimes | North Country |  |
| 2006  (79th)  | Mirren !Helen Mirren ‡ | Elizabeth !Queen Elizabeth II | Queen !The Queen |  |
| 2006  (79th)  | Cruz !Penélope Cruz | Raimunda | Volver |  |
| 2006  (79th)  | Dench !Judi Dench | Covett !Barbara Covett | Notes on a Scandal |  |
| 2006  (79th)  | Streep !Meryl Streep | Priestly !Miranda Priestly | Devil !The Devil Wears Prada |  |
| 2006  (79th)  | Winslet !Kate Winslet | Pierce !Sarah Pierce | Little Children |  |
| 2007  (80th)  | Cotillard !Marion Cotillard ‡ | Piaf !Édith Piaf | La Vie en Rose |  |
| 2007  (80th)  | Blanchett !Cate Blanchett | Elizabeth !Queen Elizabeth I | Elizabeth: The Golden Age |  |
| 2007  (80th)  | Christie !Julie Christie | Anderson !Fiona Anderson | Away from Her |  |
| 2007  (80th)  | Linney !Laura Linney | Savage !Wendy Savage | Savages !The Savages |  |
| 2007  (80th)  | Page !Elliot Page | MacGuff !Juno MacGuff | Juno |  |
| 2008  (81st)  | Winslet !Kate Winslet ‡ | Schmitz !Hanna Schmitz | Reader !The Reader |  |
| 2008  (81st)  | Hathaway !Anne Hathaway | Buchman !Kym Buchman | Rachel Getting Married |  |
| 2008  (81st)  | Jolie !Angelina Jolie | Collins !Christine Collins | Changeling |  |
| 2008  (81st)  | Leo !Melissa Leo | Eddy !Ray Eddy | Frozen River |  |
| 2008  (81st)  | Streep !Meryl Streep | Beauvier !Sister Aloysius Beauvier | Doubt |  |
| 2009  (82nd)  | Bullock !Sandra Bullock ‡ | Tuohy !Leigh Anne Tuohy | Blind !The Blind Side |  |
| 2009  (82nd)  | Mirren !Helen Mirren | Tolstaya !Sophia Tolstaya | Last !The Last Station |  |
| 2009  (82nd)  | Mulligan !Carey Mulligan | Mellor !Jenny Mellor | Education !An Education |  |
| 2009  (82nd)  | Sidibe !Gabourey Sidibe | Claireece "Precious" Jones | Precious |  |
| 2009  (82nd)  | Streep !Meryl Streep | Child !Julia Child | Julie & Julia |  |